miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p AIFM1 -1.37014061604018 3.11451492971224e-14 0.701046679657264 4.73210836532952e-09 TargetScan;miRNATAP -0.113097819095147 0.000177982745708989 NA NA NA hsa-let-7b-5p AIFM1 -1.62016148171663 1.56547487335694e-15 0.701046679657264 4.73210836532952e-09 miRNATAP -0.12394893444617 2.99656873665416e-06 NA NA NA hsa-miR-125a-5p AIFM1 -1.04824536696301 3.97386082850476e-07 0.701046679657264 4.73210836532952e-09 miRanda -0.0810306857767329 0.00248528971353028 NA NA NA hsa-miR-125b-5p AIFM1 -0.548859243919575 0.0107224406584463 0.701046679657264 4.73210836532952e-09 miRNATAP -0.0943177422318529 0.00027659277025805 NA NA NA hsa-miR-145-5p AIFM1 -1.34926078156437 2.63526538800669e-07 0.701046679657264 4.73210836532952e-09 miRNATAP -0.0922717900607229 1.05047307529608e-05 20332243 Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death prostate cancer hsa-miR-155-5p AIFM1 0.813513839059142 0.000608282725633232 0.701046679657264 4.73210836532952e-09 miRNAWalker2_validate -0.0596225145122066 0.0111649772627069 NA NA NA hsa-miR-199a-5p AIFM1 1.3057193856884 2.38429382751645e-08 0.701046679657264 4.73210836532952e-09 miRanda -0.0615958036610509 0.00902985255264593 NA NA NA hsa-miR-143-3p AKT1 -1.21021691908494 5.70938667332876e-06 -0.131043241288455 0.253475473964547 miRNAWalker2_validate -0.0583164965300849 0.00283674173270136 NA NA NA hsa-let-7a-5p AKT2 -1.37014061604018 3.11451492971224e-14 0.158500088541505 0.113504798741429 TargetScan -0.119930037553526 1.13227688326527e-06 NA NA NA hsa-miR-29a-3p AKT2 0.101650412194573 0.573201097011668 0.158500088541505 0.113504798741429 MirTarget -0.104368014677354 4.26511869332683e-05 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis acute myeloid leukemia hsa-miR-29c-3p AKT2 1.32354490728858 1.84279305179762e-07 0.158500088541505 0.113504798741429 MirTarget -0.0724234671154258 4.61661997896997e-05 NA NA NA hsa-miR-30d-3p AKT2 0.00396376345349925 0.986457040013182 0.158500088541505 0.113504798741429 mirMAP -0.0542280157997588 0.0142420066433211 NA NA NA hsa-miR-30e-3p AKT2 -0.104420043859122 0.526240453209293 0.158500088541505 0.113504798741429 mirMAP -0.0702531384509192 0.0125600056162865 NA NA NA hsa-miR-106a-5p AKT3 1.3902608059488 6.07931522284525e-05 -1.44031241124732 2.576504600149e-09 miRNATAP -0.0878809083593532 0.0154706923282101 NA NA NA hsa-miR-106b-5p AKT3 1.47447672652218 1.32004094930462e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.158920731526324 0.00425859940487133 NA NA NA hsa-miR-107 AKT3 0.658676029898313 5.11480446318819e-07 -1.44031241124732 2.576504600149e-09 PITA;miRanda -0.256548300142307 0.00309702957622585 NA NA NA hsa-miR-142-3p AKT3 3.98476449801341 1.56256182021111e-35 -1.44031241124732 2.576504600149e-09 miRanda -0.0983514928109642 0.00259729734649049 NA NA NA hsa-miR-146b-5p AKT3 1.0922867893808 5.63754607494775e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate -0.14508398550335 0.00188822517544197 NA NA NA hsa-miR-15a-5p AKT3 1.62575353599172 1.55312121019827e-19 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.412918804091755 4.08840965026726e-12 NA NA NA hsa-miR-16-5p AKT3 0.749619098384047 4.11649450706988e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.269698520974258 9.94440318719177e-05 NA NA NA hsa-miR-17-3p AKT3 1.36706429551147 4.60388403547821e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.150903286752378 0.0102655088674849 NA NA NA hsa-miR-17-5p AKT3 2.07078488653279 2.77403038572568e-19 -1.44031241124732 2.576504600149e-09 TargetScan;miRNATAP -0.217476886844258 3.56953935954486e-06 NA NA NA hsa-miR-181a-5p AKT3 -0.375429731222937 0.0562142867129802 -1.44031241124732 2.576504600149e-09 miRNATAP -0.22550600060725 9.19470016250579e-05 NA NA NA hsa-miR-181b-5p AKT3 0.668793269169928 0.000239998092406404 -1.44031241124732 2.576504600149e-09 miRNATAP -0.367498754199467 2.09865276667175e-09 NA NA NA hsa-miR-20a-5p AKT3 2.64649625616975 5.1469418982085e-27 -1.44031241124732 2.576504600149e-09 miRNATAP -0.24430728120197 1.27608550819212e-08 NA NA NA hsa-miR-22-3p AKT3 1.42501909916631 1.72295005910055e-25 -1.44031241124732 2.576504600149e-09 miRNATAP -0.259390140878921 0.0010937362716222 NA NA NA hsa-miR-28-3p AKT3 0.387144500601444 0.00777919765254534 -1.44031241124732 2.576504600149e-09 miRNATAP -0.197315516871575 0.0122556173898666 NA NA NA hsa-miR-29a-3p AKT3 0.101650412194573 0.573201097011668 -1.44031241124732 2.576504600149e-09 miRNATAP -0.147280324253872 0.0201558550795979 NA NA NA hsa-miR-29b-2-5p AKT3 0.345881055247341 0.194842633194187 -1.44031241124732 2.576504600149e-09 mirMAP -0.181342398720756 1.80199534450665e-05 NA NA NA hsa-miR-29b-3p AKT3 3.10527711861309 3.01242507282711e-32 -1.44031241124732 2.576504600149e-09 miRNATAP -0.267243460090773 1.17871192498365e-11 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 0.653308707552535 0.0999497219778851 -1.44031241124732 2.576504600149e-09 mirMAP -0.18242132898273 2.34990243224026e-09 NA NA NA hsa-miR-335-3p AKT3 1.51116383169018 6.88553098788624e-13 -1.44031241124732 2.576504600149e-09 mirMAP -0.134576700675304 0.0106735082003925 NA NA NA hsa-miR-362-5p AKT3 0.658947634569393 0.0243306847205756 -1.44031241124732 2.576504600149e-09 PITA;TargetScan;miRNATAP -0.229571357984291 4.43564207755877e-09 NA NA NA hsa-miR-424-5p AKT3 1.26485330287919 6.1498991028257e-06 -1.44031241124732 2.576504600149e-09 miRNATAP -0.0918851034499394 0.0222513917997985 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth liver cancer hsa-miR-542-3p AKT3 1.62226640768239 2.6427102465476e-10 -1.44031241124732 2.576504600149e-09 miRanda -0.186790699816246 1.44501888663791e-05 NA NA NA hsa-miR-93-5p AKT3 1.50844106515467 1.83836866996875e-12 -1.44031241124732 2.576504600149e-09 miRNATAP -0.251105283811718 1.01733106411986e-06 NA NA NA hsa-miR-195-3p APAF1 -1.33068822339418 6.65427393047357e-09 0.0527330819081095 0.628296064246439 mirMAP -0.0559201782208461 0.00935508813067922 NA NA NA hsa-miR-23a-3p APAF1 0.111958289789488 0.393086414480463 0.0527330819081095 0.628296064246439 miRNATAP -0.131163580903016 0.000690306154175996 24992592;24249161 Luciferase assay was performed to verify a putative target site of miR-23a in the 3'-UTR of apoptosis protease activating factor 1 APAF1 mRNA; The expression levels of miR-23a and APAF1 in CRC cell lines SW480 and SW620 and clinical samples were assessed using reverse transcription-quantitative real-time PCR RT-qPCR and Western blot; Moreover miR-23a up-regulation was coupled with APAF1 down-regulation in CRC tissue samples;We found that the expression of miR-23a was increased and the level of apoptosis-activating factor-1 APAF-1 was decreased in 5-FU-treated colon cancer cells compared to untreated cells; APAF-1 as a target gene of miR-23a was identified and miR-23a antisense-induced increase in the activation of caspase-9 was observed ; colorectal cancer;colorectal cancer hsa-miR-23b-3p APAF1 -0.070273068040148 0.620585267977425 0.0527330819081095 0.628296064246439 miRNATAP -0.109314526987903 0.00215543348816896 NA NA NA hsa-miR-27a-3p APAF1 0.433402568013802 0.00737164631768323 0.0527330819081095 0.628296064246439 miRNATAP -0.16468480576707 8.19227183327682e-08 NA NA NA hsa-miR-27b-3p APAF1 0.236438984240408 0.12263510345883 0.0527330819081095 0.628296064246439 miRNATAP -0.166392707369462 3.36486831782177e-07 NA NA NA hsa-miR-374b-5p APAF1 0.474691035780475 0.0109217471394203 0.0527330819081095 0.628296064246439 mirMAP -0.0705437026364295 0.0128580603458184 NA NA NA hsa-miR-664a-3p APAF1 0.443077463053857 0.0214248925850984 0.0527330819081095 0.628296064246439 mirMAP -0.111814656754016 1.51855061714124e-05 NA NA NA hsa-miR-125a-3p ATM -1.04954492275266 2.45974219476832e-06 0.084170685461789 0.530133846216819 miRanda -0.0634680390793827 0.0207433994681444 NA NA NA hsa-miR-18a-5p ATM 1.37435209536521 9.2173853686829e-06 0.084170685461789 0.530133846216819 miRNAWalker2_validate;miRTarBase;MirTarget -0.0754100658198159 0.000395291321432484 23437304;25963391;23857602;23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression colorectal cancer;cervical and endocervical cancer;breast cancer;colon cancer hsa-miR-590-5p ATM 2.07441240363458 4.95240551694843e-14 0.084170685461789 0.530133846216819 mirMAP -0.0741120791561602 0.00604329297548224 NA NA NA hsa-miR-15a-5p BCL2 1.62575353599172 1.55312121019827e-19 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.187458177651156 0.00400964703367561 26915294;25594541;18931683;25623762;22335947 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 poor survival;;;drug resistance; lung cancer;breast cancer;prostate cancer;colon cancer;breast cancer hsa-miR-17-5p BCL2 2.07078488653279 2.77403038572568e-19 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.116338876463301 0.0217440105866914 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-200c-3p BCL2 0.380533388300368 0.0842181838538353 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase;mirMAP -0.126651991360998 0.022049998757799 NA NA NA hsa-miR-20a-3p BCL2 2.51803599558247 4.92479325298629e-13 -0.487496069869486 0.0642113742980754 mirMAP -0.102394535742893 0.0197408442233094 NA NA NA hsa-miR-20a-5p BCL2 2.64649625616975 5.1469418982085e-27 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.115004935478343 0.0136833763472092 NA NA NA hsa-miR-21-5p BCL2 4.38165933891779 1.52536633902505e-92 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.204010104736014 8.81514964878011e-06 22964582;21468550;25994220;25381586;26555418;23359184;21376256 Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance lung cancer;bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;pancreatic cancer hsa-miR-224-5p BCL2 1.9183903633152 3.22216766330296e-06 -0.487496069869486 0.0642113742980754 mirMAP -0.138108415745186 1.72321765526623e-06 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 1.43704663046967 4.34375016509278e-11 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.15947750861285 0.00351654011349327 NA NA NA hsa-miR-29a-5p BCL2 1.89519956688438 1.03453349363915e-11 -0.487496069869486 0.0642113742980754 mirMAP -0.237477310346695 2.67918561276733e-06 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29b-3p BCL2 3.10527711861309 3.01242507282711e-32 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.0967805337416638 0.0248458522536524 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-3065-5p BCL2 0.653308707552535 0.0999497219778851 -0.487496069869486 0.0642113742980754 mirMAP -0.121892398301854 0.000231812969788831 NA NA NA hsa-miR-33a-5p BCL2 2.80127809675219 5.09053890529424e-12 -0.487496069869486 0.0642113742980754 mirMAP -0.0975998264075783 0.00700528692673911 NA NA NA hsa-miR-34a-5p BCL2 1.40588612517769 8.60097477768592e-12 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.185078875528925 0.00135283473559727 22964582;24565525;23155233;24444609;20687223;22623155;24988056;18803879;19714243;25053345;20433755;21399894;23862748 Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression ;drug resistance;;poor survival;drug resistance;;;poor survival;differentiation;poor survival;drug resistance;;; lung cancer;breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;breast cancer;liver cancer hsa-miR-365a-3p BCL2 0.0132777124336201 0.953597412537431 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.135798592942671 0.0110668436109814 NA NA NA hsa-miR-450b-5p BCL2 1.69248953402469 1.96052058003353e-07 -0.487496069869486 0.0642113742980754 mirMAP -0.19720389328785 1.37276161625093e-06 NA NA NA hsa-miR-452-5p BCL2 0.637123950346362 0.0458173998136196 -0.487496069869486 0.0642113742980754 mirMAP -0.123489150343591 0.00113373620964249 NA NA NA hsa-miR-542-3p BCL2 1.62226640768239 2.6427102465476e-10 -0.487496069869486 0.0642113742980754 mirMAP -0.191093289471344 3.49857445479472e-05 NA NA NA hsa-miR-590-3p BCL2 0.83851360565783 0.00129224433453587 -0.487496069869486 0.0642113742980754 miRanda;mirMAP -0.123434669030393 0.0270457405646397 NA NA NA hsa-miR-590-5p BCL2 2.07441240363458 4.95240551694843e-14 -0.487496069869486 0.0642113742980754 miRanda -0.183833993408744 0.000541716198465799 NA NA NA hsa-miR-96-5p BCL2 3.0381097138467 4.40362891630201e-24 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;TargetScan -0.137358301513432 0.0019288325262615 NA NA NA hsa-miR-326 BCL2L1 -0.992397386750901 0.00335173765975096 -0.253690983086026 0.0773242401440008 PITA;miRanda;mirMAP;miRNATAP -0.0626248434483971 0.00125042224531858 NA NA NA hsa-miR-330-5p BCL2L1 0.168520831101569 0.336433937906706 -0.253690983086026 0.0773242401440008 PITA;miRanda;miRNATAP -0.0815974317577436 0.0319461097353943 NA NA NA hsa-miR-421 BCL2L1 0.170525317701774 0.535277026680289 -0.253690983086026 0.0773242401440008 miRanda -0.0900187037562723 0.000555118442470486 NA NA NA hsa-miR-204-5p BIRC2 -1.01965803752657 0.00767207541525746 -0.0566424270372563 0.620255875001944 miRNAWalker2_validate;miRTarBase;MirTarget -0.0782934385963493 8.69941608437788e-09 NA NA NA hsa-miR-29a-3p BIRC2 0.101650412194573 0.573201097011668 -0.0566424270372563 0.620255875001944 MirTarget -0.0600985083787739 0.0403518090815847 NA NA NA hsa-miR-29b-3p BIRC2 3.10527711861309 3.01242507282711e-32 -0.0566424270372563 0.620255875001944 MirTarget -0.0570026769162778 0.00213868248761565 NA NA NA hsa-miR-500a-5p BIRC2 0.648155655714409 0.0104657432932038 -0.0566424270372563 0.620255875001944 MirTarget -0.112472951411246 8.53911662639019e-08 NA NA NA hsa-miR-624-5p BIRC2 -0.0554776050468686 0.829845479813552 -0.0566424270372563 0.620255875001944 MirTarget -0.0532100950283452 0.0200105064105171 NA NA NA hsa-miR-24-1-5p BIRC3 0.856025727237819 0.000107354490323658 0.125427105924507 0.676483616271283 MirTarget -0.206759039423342 0.0016525543606198 NA NA NA hsa-miR-375 BIRC3 0.615547997686534 0.149199273675144 0.125427105924507 0.676483616271283 miRNAWalker2_validate -0.195933533083944 7.50694584162728e-10 23726271 Taken together these data suggest that miR-375 sensitizes TNF-α-induced apoptosis and the reduction in the expression of the apoptosis inhibitory proteins cFLIP-L and cIAP2 plays an important role in this sensitization head and neck cancer hsa-miR-664a-3p BIRC3 0.443077463053857 0.0214248925850984 0.125427105924507 0.676483616271283 mirMAP -0.16585436385996 0.0215980202864507 NA NA NA hsa-miR-98-5p BIRC3 1.170602085804 1.09900501665229e-08 0.125427105924507 0.676483616271283 miRNAWalker2_validate -0.135956769299651 0.0476049079151008 NA NA NA hsa-miR-107 CAPN2 0.658676029898313 5.11480446318819e-07 -0.307487246393565 0.0517639236874996 miRanda -0.129487592988861 0.020246847954034 NA NA NA hsa-miR-1468-5p CAPN2 -0.89642552207747 0.0007195345670695 -0.307487246393565 0.0517639236874996 MirTarget -0.0569349702225368 0.0376391873165354 NA NA NA hsa-miR-16-2-3p CAPN2 0.503964803530872 0.0263648405197492 -0.307487246393565 0.0517639236874996 mirMAP -0.11004591764374 0.00157478022798458 NA NA NA hsa-miR-20a-3p CAPN2 2.51803599558247 4.92479325298629e-13 -0.307487246393565 0.0517639236874996 MirTarget -0.126718135438292 1.16532550012936e-06 NA NA NA hsa-miR-320b CAPN2 0.226640952564488 0.378818692487242 -0.307487246393565 0.0517639236874996 miRanda -0.123991691232165 1.04526537750598e-05 NA NA NA hsa-miR-421 CAPN2 0.170525317701774 0.535277026680289 -0.307487246393565 0.0517639236874996 miRanda -0.157545501874524 3.03052816875822e-08 NA NA NA hsa-miR-590-3p CAPN2 0.83851360565783 0.00129224433453587 -0.307487246393565 0.0517639236874996 miRanda -0.0992741312174916 0.00294343668188339 NA NA NA hsa-miR-590-5p CAPN2 2.07441240363458 4.95240551694843e-14 -0.307487246393565 0.0517639236874996 miRanda -0.160886327978009 3.58492015382408e-07 NA NA NA hsa-miR-7-5p CAPN2 0.343825848926135 0.435063427976906 -0.307487246393565 0.0517639236874996 miRNAWalker2_validate -0.0819956045664036 6.4604772431401e-05 NA NA NA hsa-miR-129-5p CASP10 -0.405735314747643 0.341485636033577 -0.273124939830875 0.0980559181398398 mirMAP -0.0566597084776637 0.00150976706125067 NA NA NA hsa-miR-148b-5p CASP10 1.39335695292409 2.13220380550073e-07 -0.273124939830875 0.0980559181398398 mirMAP -0.142918818215108 1.84018593774494e-05 NA NA NA hsa-miR-19a-3p CASP10 2.11776595911517 7.07663078397156e-10 -0.273124939830875 0.0980559181398398 MirTarget;mirMAP -0.103748849625307 5.82215966866069e-05 NA NA NA hsa-miR-19b-1-5p CASP10 1.71217036351784 3.28561659177495e-12 -0.273124939830875 0.0980559181398398 mirMAP -0.180380873043991 1.8051624722446e-07 NA NA NA hsa-miR-19b-3p CASP10 2.10868505662119 5.40846613768389e-17 -0.273124939830875 0.0980559181398398 MirTarget;mirMAP -0.117954936938626 0.000117554430485811 NA NA NA hsa-miR-200c-3p CASP10 0.380533388300368 0.0842181838538353 -0.273124939830875 0.0980559181398398 mirMAP -0.0684789998832118 0.0480035507619918 NA NA NA hsa-miR-320b CASP10 0.226640952564488 0.378818692487242 -0.273124939830875 0.0980559181398398 miRanda -0.0937877517069347 0.00148514387380535 NA NA NA hsa-miR-421 CASP10 0.170525317701774 0.535277026680289 -0.273124939830875 0.0980559181398398 mirMAP -0.173186299099511 5.10535452071279e-09 NA NA NA hsa-miR-744-3p CASP10 2.07439104592565 3.30645434602132e-12 -0.273124939830875 0.0980559181398398 mirMAP -0.132075541742933 7.93996713929531e-08 NA NA NA hsa-let-7a-5p CASP3 -1.37014061604018 3.11451492971224e-14 0.749868979708077 8.30799302647668e-11 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.0909980831533757 0.00188543462908328 NA NA NA hsa-let-7b-5p CASP3 -1.62016148171663 1.56547487335694e-15 0.749868979708077 8.30799302647668e-11 MirTarget;miRNATAP -0.0653651988492036 0.0116242936549475 NA NA NA hsa-let-7c-5p CASP3 -2.14139413005852 1.66416999341685e-18 0.749868979708077 8.30799302647668e-11 MirTarget -0.0749964976138593 0.000432137669149612 NA NA NA hsa-miR-139-5p CASP3 -2.26625553116965 7.22375119369519e-16 0.749868979708077 8.30799302647668e-11 miRanda -0.103400450602475 1.92824413318983e-08 NA NA NA hsa-miR-195-3p CASP3 -1.33068822339418 6.65427393047357e-09 0.749868979708077 8.30799302647668e-11 MirTarget -0.12156615230384 1.38560895801409e-07 NA NA NA hsa-miR-30a-5p CASP3 -0.924084264430689 0.000762030454634728 0.749868979708077 8.30799302647668e-11 miRNATAP -0.0921641666988453 2.21534822290327e-06 NA NA NA hsa-miR-30c-5p CASP3 -0.327319105755825 0.123595832152687 0.749868979708077 8.30799302647668e-11 miRNATAP -0.14954468041522 2.8553699558622e-09 NA NA NA hsa-miR-30d-5p CASP3 -0.920901858717441 3.50898334321668e-05 0.749868979708077 8.30799302647668e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.173377620122409 2.06657661969359e-13 NA NA NA hsa-miR-362-3p CASP3 0.194097672030785 0.52808475179225 0.749868979708077 8.30799302647668e-11 miRanda -0.057893036079493 0.00859004289322215 NA NA NA hsa-miR-374a-5p CASP3 -0.197027254874826 0.298080902192861 0.749868979708077 8.30799302647668e-11 mirMAP -0.0670412394749672 0.0378988789329181 NA NA NA hsa-miR-125a-5p CASP6 -1.04824536696301 3.97386082850476e-07 0.904444256335095 7.02954024495495e-11 miRanda -0.117486960142462 0.000160301516487637 NA NA NA hsa-miR-106b-5p CASP7 1.47447672652218 1.32004094930462e-13 -0.211288307918442 0.0813860667885838 miRNAWalker2_validate -0.0641096214587668 0.0190659596781726 22986525 MicroRNA 106b 25 cluster expression is associated with early disease recurrence and targets caspase 7 and focal adhesion in human prostate cancer; Moreover increased tumor miR-106b expression was associated with disease recurrence and the combination of high miR-106b and low CASP7 caspase-7 expressions in primary tumors was an independent predictor of early disease recurrence adjusted hazard ratio=4.1; 95% confidence interval: 1.6-12.3; The approach revealed that CASP7 is a direct target of miR-106b which was confirmed by western blot analysis and a 3'-untranslated region reporter assay; Moreover selected phenotypes induced by miR-106b knockdown in DU145 human prostate cancer cells did not develop when both miR-106b and CASP7 expression were inhibited recurrence prostate cancer hsa-miR-664a-3p CASP7 0.443077463053857 0.0214248925850984 -0.211288307918442 0.0813860667885838 MirTarget -0.108240210919283 0.000181784451993205 NA NA NA hsa-miR-17-5p CASP8 2.07078488653279 2.77403038572568e-19 0.38492371586644 0.00231695213409484 MirTarget -0.0747257769061046 0.00207100689125201 NA NA NA hsa-miR-19b-1-5p CASP8 1.71217036351784 3.28561659177495e-12 0.38492371586644 0.00231695213409484 miRNAWalker2_validate -0.0714194422853538 0.00767606285624013 NA NA NA hsa-miR-19b-3p CASP8 2.10868505662119 5.40846613768389e-17 0.38492371586644 0.00231695213409484 MirTarget -0.0528934712366989 0.0250540304663595 NA NA NA hsa-miR-20a-5p CASP8 2.64649625616975 5.1469418982085e-27 0.38492371586644 0.00231695213409484 MirTarget -0.0503053704921421 0.0246354489361094 NA NA NA hsa-miR-93-5p CASP8 1.50844106515467 1.83836866996875e-12 0.38492371586644 0.00231695213409484 MirTarget -0.0629133547445801 0.0182514667162296 NA NA NA hsa-miR-195-5p CASP9 -1.01577502605386 4.80814718341729e-05 -0.0284878808167806 0.825547614515027 mirMAP -0.0624713305629546 0.012071299006958 NA NA NA hsa-miR-199a-3p CASP9 1.67715607711377 5.96963028176444e-15 -0.0284878808167806 0.825547614515027 mirMAP -0.0875540210266416 0.00108468527310128 23319430 The techniques used were the MTT assay flow cytometry real-time PCR to assess miR-199a expression as also caspase-8 and caspase-9 activity in HepG2 cells treated with Propofol liver cancer hsa-miR-199b-3p CASP9 1.67802185853505 6.03525898173555e-15 -0.0284878808167806 0.825547614515027 mirMAP -0.0874411244180649 0.00109229053138754 NA NA NA hsa-miR-222-5p CASP9 0.0957775494210593 0.719329365268725 -0.0284878808167806 0.825547614515027 mirMAP -0.0533815272249085 0.016730441519203 NA NA NA hsa-miR-342-5p CASP9 -0.382174669348421 0.0896996965047193 -0.0284878808167806 0.825547614515027 MirTarget -0.0670888834486345 0.0110721509157536 NA NA NA hsa-miR-497-5p CASP9 -0.0546347378264729 0.786205564901684 -0.0284878808167806 0.825547614515027 mirMAP -0.0787112258948791 0.00786279930667864 NA NA NA hsa-miR-107 CFLAR 0.658676029898313 5.11480446318819e-07 -0.60264981549415 0.000146924534874046 miRanda -0.150916593963368 0.00732127376323208 NA NA NA hsa-miR-130b-3p CFLAR 1.83046548750752 5.04753914574694e-13 -0.60264981549415 0.000146924534874046 mirMAP -0.170030964912425 7.49012425842225e-09 NA NA NA hsa-miR-186-5p CFLAR 0.852175445703945 6.88885738584309e-10 -0.60264981549415 0.000146924534874046 mirMAP -0.109533084884528 0.0388776272198057 NA NA NA hsa-miR-301a-3p CFLAR 2.70198002906399 1.56420889710984e-14 -0.60264981549415 0.000146924534874046 mirMAP -0.0604172993436135 0.0163672497418459 NA NA NA hsa-miR-320b CFLAR 0.226640952564488 0.378818692487242 -0.60264981549415 0.000146924534874046 miRanda -0.151195453642841 8.91238898066211e-08 NA NA NA hsa-miR-330-5p CFLAR 0.168520831101569 0.336433937906706 -0.60264981549415 0.000146924534874046 miRanda -0.105748491906056 0.0123982677165611 NA NA NA hsa-miR-421 CFLAR 0.170525317701774 0.535277026680289 -0.60264981549415 0.000146924534874046 miRanda -0.108323835564755 0.000185502533497704 NA NA NA hsa-miR-454-3p CFLAR 1.49453641052169 4.46235742871434e-09 -0.60264981549415 0.000146924534874046 mirMAP -0.110766292193923 0.00110247176076177 NA NA NA hsa-miR-550a-5p CFLAR 0.59977150019756 0.0314775340172755 -0.60264981549415 0.000146924534874046 mirMAP -0.0647278610417015 0.0142590103357571 NA NA NA hsa-miR-708-5p CFLAR 3.04047795672813 3.01085192850869e-20 -0.60264981549415 0.000146924534874046 mirMAP -0.102498067556773 1.52497290863615e-05 NA NA NA hsa-miR-106b-5p CHP2 1.47447672652218 1.32004094930462e-13 -0.698246795377642 0.27546655425478 MirTarget -0.289307563984085 0.046059718658527 NA NA NA hsa-miR-582-5p CHP2 1.08286181406653 0.00149040450161757 -0.698246795377642 0.27546655425478 miRNATAP -0.174545230260245 0.0486087191670937 NA NA NA hsa-miR-148a-3p CHUK 2.30885799126944 1.95226081368985e-21 0.0377297766878195 0.74424413982199 MirTarget -0.0662015128745263 0.00149521257483326 NA NA NA hsa-miR-15a-5p CHUK 1.62575353599172 1.55312121019827e-19 0.0377297766878195 0.74424413982199 miRNAWalker2_validate;miRTarBase;MirTarget -0.156480048093973 2.55421092282135e-08 NA NA NA hsa-miR-15b-5p CHUK -1.25935038177398 1.83460220856901e-12 0.0377297766878195 0.74424413982199 MirTarget -0.0601290134141077 0.0392581481188275 NA NA NA hsa-miR-195-5p CHUK -1.01577502605386 4.80814718341729e-05 0.0377297766878195 0.74424413982199 miRNAWalker2_validate;MirTarget -0.0642567434396982 0.00383688889529767 NA NA NA hsa-miR-23b-3p CHUK -0.070273068040148 0.620585267977425 0.0377297766878195 0.74424413982199 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.0758154515787172 0.0458175912583452 NA NA NA hsa-miR-29b-2-5p CHUK 0.345881055247341 0.194842633194187 0.0377297766878195 0.74424413982199 MirTarget -0.119533869512923 1.02102108327589e-09 NA NA NA hsa-miR-339-5p CHUK 0.536997313601114 0.0488090394176611 0.0377297766878195 0.74424413982199 miRanda -0.101676919866514 1.24374098863621e-07 NA NA NA hsa-miR-342-3p CHUK -0.128691966564961 0.561034080130801 0.0377297766878195 0.74424413982199 miRanda -0.176769532720248 4.41422217910121e-14 NA NA NA hsa-miR-362-3p CHUK 0.194097672030785 0.52808475179225 0.0377297766878195 0.74424413982199 miRanda -0.0696828309577434 0.0012134632500459 NA NA NA hsa-miR-376c-3p CHUK 0.0198899124097713 0.95781494364483 0.0377297766878195 0.74424413982199 MirTarget -0.0587297607352403 8.48476187870898e-05 NA NA NA hsa-miR-429 CHUK 2.3794516574089 1.72813419703734e-13 0.0377297766878195 0.74424413982199 miRanda -0.0598314200288533 0.000532322125008197 NA NA NA hsa-miR-497-5p CHUK -0.0546347378264729 0.786205564901684 0.0377297766878195 0.74424413982199 MirTarget -0.194599570543196 4.42801403790986e-14 NA NA NA hsa-miR-15b-3p CSF2RB 0.804736041893915 0.000400279611457186 -1.28440879414381 5.98600010060944e-07 mirMAP -0.146763154921606 0.00821763442889796 NA NA NA hsa-miR-181d-5p CSF2RB 1.19058140522592 8.5908558852417e-09 -1.28440879414381 5.98600010060944e-07 MirTarget -0.225138318949885 7.93227254228292e-05 NA NA NA hsa-miR-19a-3p CSF2RB 2.11776595911517 7.07663078397156e-10 -1.28440879414381 5.98600010060944e-07 MirTarget -0.167733606420829 3.84098493798594e-05 NA NA NA hsa-miR-19b-3p CSF2RB 2.10868505662119 5.40846613768389e-17 -1.28440879414381 5.98600010060944e-07 MirTarget -0.250069990582844 1.95558645843003e-07 NA NA NA hsa-miR-139-5p CYCS -2.26625553116965 7.22375119369519e-16 0.533584069273294 0.000797541450763797 miRanda -0.177347725394177 7.68044998537411e-13 NA NA NA hsa-miR-200a-3p CYCS 3.14766878548496 1.32850889777422e-21 0.533584069273294 0.000797541450763797 mirMAP -0.0631633638672565 0.00378326334312585 NA NA NA hsa-miR-3065-5p CYCS 0.653308707552535 0.0999497219778851 0.533584069273294 0.000797541450763797 mirMAP -0.0768473138262738 0.000125375397818456 NA NA NA hsa-miR-342-3p CYCS -0.128691966564961 0.561034080130801 0.533584069273294 0.000797541450763797 mirMAP -0.104452481938135 0.00171342515724575 NA NA NA hsa-miR-34b-3p CYCS -1.69479533615636 0.00178266322862085 0.533584069273294 0.000797541450763797 mirMAP -0.0710729685026357 3.20343101082997e-07 NA NA NA hsa-miR-34c-3p CYCS -1.35308017238309 0.0061932035503795 0.533584069273294 0.000797541450763797 mirMAP -0.0582401312057802 7.83428048987959e-05 NA NA NA hsa-miR-34c-5p CYCS -1.00125440032112 0.0724432896090357 0.533584069273294 0.000797541450763797 miRanda -0.0697878547934284 3.66496516713039e-07 NA NA NA hsa-miR-532-5p CYCS 0.576620898517708 0.0023245812680956 0.533584069273294 0.000797541450763797 PITA -0.0891202871112289 0.0221590751964209 NA NA NA hsa-miR-145-5p DFFA -1.34926078156437 2.63526538800669e-07 0.208253468929684 0.0467186752814201 miRNAWalker2_validate;miRTarBase -0.0869547781229821 1.28374730239976e-06 NA NA NA hsa-miR-155-5p DFFA 0.813513839059142 0.000608282725633232 0.208253468929684 0.0467186752814201 mirMAP -0.0656608123924715 0.00111854020073062 NA NA NA hsa-miR-26a-2-3p DFFA 0.264287787772609 0.305653616292982 0.208253468929684 0.0467186752814201 mirMAP -0.0523898471804812 0.024609378970448 NA NA NA hsa-miR-26a-5p DFFA -0.126411409001078 0.440028840408711 0.208253468929684 0.0467186752814201 mirMAP -0.0801168579661237 0.00687508444277685 NA NA NA hsa-miR-320a DFFA -0.961144925954715 1.62478794429204e-08 0.208253468929684 0.0467186752814201 miRanda -0.0568256292088207 0.0428424524763407 NA NA NA hsa-miR-342-3p DFFA -0.128691966564961 0.561034080130801 0.208253468929684 0.0467186752814201 mirMAP -0.115285301351606 8.73927415674084e-08 NA NA NA hsa-miR-664a-3p DFFA 0.443077463053857 0.0214248925850984 0.208253468929684 0.0467186752814201 mirMAP -0.110989880099499 8.08861826721901e-06 NA NA NA hsa-miR-330-3p DFFB -0.716924999893351 0.000796236278616087 0.546892122693686 1.60242947893897e-05 mirMAP -0.05527529251776 0.0443778710546971 NA NA NA hsa-miR-365a-3p DFFB 0.0132777124336201 0.953597412537431 0.546892122693686 1.60242947893897e-05 MirTarget -0.120376568746021 2.66199233996373e-06 NA NA NA hsa-miR-421 DFFB 0.170525317701774 0.535277026680289 0.546892122693686 1.60242947893897e-05 miRNAWalker2_validate;MirTarget;miRanda -0.0533927868060745 0.021742484945623 NA NA NA hsa-miR-130a-3p ENDOD1 0.881660100597014 0.000158893668519248 0.0574724229589449 0.802287884473109 MirTarget -0.158689380972218 0.00041229224437697 NA NA NA hsa-miR-130b-3p ENDOD1 1.83046548750752 5.04753914574694e-13 0.0574724229589449 0.802287884473109 MirTarget -0.210698970673308 6.99903178813071e-07 NA NA NA hsa-miR-16-1-3p ENDOD1 1.50034693398929 6.63958242991125e-10 0.0574724229589449 0.802287884473109 mirMAP -0.115978052272091 0.0292641693507515 NA NA NA hsa-miR-181d-5p ENDOD1 1.19058140522592 8.5908558852417e-09 0.0574724229589449 0.802287884473109 MirTarget -0.12246584317684 0.0152429489204304 NA NA NA hsa-miR-192-5p ENDOD1 2.03412119423736 1.6357945826287e-05 0.0574724229589449 0.802287884473109 miRNAWalker2_validate -0.0923029642721004 2.72727273478348e-05 NA NA NA hsa-miR-193a-3p ENDOD1 0.549173467360291 0.0319030569365466 0.0574724229589449 0.802287884473109 miRanda -0.179134327621172 5.86428802529883e-05 NA NA NA hsa-miR-193b-3p ENDOD1 1.10444771306846 0.000822888533401377 0.0574724229589449 0.802287884473109 miRNAWalker2_validate -0.193643641182539 6.00652244423002e-10 NA NA NA hsa-miR-19a-3p ENDOD1 2.11776595911517 7.07663078397156e-10 0.0574724229589449 0.802287884473109 mirMAP -0.235527854014124 2.65333290963475e-11 NA NA NA hsa-miR-19b-3p ENDOD1 2.10868505662119 5.40846613768389e-17 0.0574724229589449 0.802287884473109 mirMAP -0.214871885885688 3.84099142028988e-07 NA NA NA hsa-miR-20a-3p ENDOD1 2.51803599558247 4.92479325298629e-13 0.0574724229589449 0.802287884473109 MirTarget -0.258852413152086 4.13602159312108e-12 NA NA NA hsa-miR-26b-3p ENDOD1 1.37388760789373 8.32526977075803e-09 0.0574724229589449 0.802287884473109 mirMAP -0.162737534659261 0.000183085338364621 NA NA NA hsa-miR-301a-3p ENDOD1 2.70198002906399 1.56420889710984e-14 0.0574724229589449 0.802287884473109 MirTarget -0.118583472939953 0.00100830851237753 NA NA NA hsa-miR-330-5p ENDOD1 0.168520831101569 0.336433937906706 0.0574724229589449 0.802287884473109 miRanda -0.177326193881245 0.00347844815306811 NA NA NA hsa-miR-335-3p ENDOD1 1.51116383169018 6.88553098788624e-13 0.0574724229589449 0.802287884473109 MirTarget -0.1214967075304 0.0133545590055334 NA NA NA hsa-miR-3607-3p ENDOD1 2.4103172144469 2.69039449048047e-08 0.0574724229589449 0.802287884473109 MirTarget;miRNATAP -0.058297131992116 0.0149648104347839 NA NA NA hsa-miR-3613-5p ENDOD1 0.0237159233591191 0.934730899070298 0.0574724229589449 0.802287884473109 MirTarget -0.0985211847671101 0.0243893585754172 NA NA NA hsa-miR-454-3p ENDOD1 1.49453641052169 4.46235742871434e-09 0.0574724229589449 0.802287884473109 MirTarget -0.200136555991206 3.83646380056291e-05 NA NA NA hsa-miR-493-5p ENDOD1 0.491314139739658 0.134743813669005 0.0574724229589449 0.802287884473109 MirTarget -0.0797781114022268 0.0130524858037004 NA NA NA hsa-miR-589-3p ENDOD1 1.34253876396688 1.84935927493927e-05 0.0574724229589449 0.802287884473109 mirMAP -0.089776308342437 0.00923751674562116 NA NA NA hsa-miR-590-3p ENDOD1 0.83851360565783 0.00129224433453587 0.0574724229589449 0.802287884473109 miRanda -0.138507749964506 0.00426365654870339 NA NA NA hsa-miR-200c-3p EXOG 0.380533388300368 0.0842181838538353 -0.186000325296265 0.0840226962857193 MirTarget -0.082662048188851 0.000223091883010291 NA NA NA hsa-miR-24-3p EXOG -0.0357874587555003 0.785865078836504 -0.186000325296265 0.0840226962857193 MirTarget -0.104890843185061 0.00597723200942725 NA NA NA hsa-miR-28-5p EXOG 1.19639196514745 4.59365801666536e-18 -0.186000325296265 0.0840226962857193 miRanda -0.0753785369668628 0.0309460386331184 NA NA NA hsa-miR-330-5p EXOG 0.168520831101569 0.336433937906706 -0.186000325296265 0.0840226962857193 miRanda -0.0604019038932048 0.0336847504692956 NA NA NA hsa-miR-146a-5p FADD 0.684701497250824 0.0105316554224149 0.682523992355391 3.44805796423382e-09 miRNAWalker2_validate;miRTarBase -0.0586254065243842 0.00450594199047627 NA NA NA hsa-miR-15b-5p FADD -1.25935038177398 1.83460220856901e-12 0.682523992355391 3.44805796423382e-09 miRNAWalker2_validate -0.0879434260726314 0.00297536533100974 NA NA NA hsa-miR-320a FADD -0.961144925954715 1.62478794429204e-08 0.682523992355391 3.44805796423382e-09 MirTarget;miRanda -0.0941742590663178 0.00272566196703511 NA NA NA hsa-miR-106a-5p FAS 1.3902608059488 6.07931522284525e-05 -0.878746828084236 0.000340153420442741 miRNAWalker2_validate;miRTarBase -0.274948885695996 7.27787651364869e-15 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-590-5p FAS 2.07441240363458 4.95240551694843e-14 -0.878746828084236 0.000340153420442741 miRanda -0.282578087201106 9.10535063456113e-09 NA NA NA hsa-let-7e-5p FASLG -0.749418249305995 7.34668338492227e-05 0.227219484524508 0.525243087995098 miRNATAP -0.243056494896728 0.00520293662614488 NA NA NA hsa-miR-125a-3p IKBKB -1.04954492275266 2.45974219476832e-06 0.288434912217645 0.0855457779032307 miRanda -0.0700667575379591 0.0419938588341739 NA NA NA hsa-miR-107 IKBKG 0.658676029898313 5.11480446318819e-07 0.0843830838323729 0.544710841322622 miRanda -0.126711425730293 0.00969342977912645 NA NA NA hsa-miR-143-3p IKBKG -1.21021691908494 5.70938667332876e-06 0.0843830838323729 0.544710841322622 mirMAP -0.162693115202678 2.58257152475095e-12 NA NA NA hsa-miR-17-3p IKBKG 1.36706429551147 4.60388403547821e-13 0.0843830838323729 0.544710841322622 mirMAP -0.124943383525099 0.000155383572679206 NA NA NA hsa-miR-24-3p IKBKG -0.0357874587555003 0.785865078836504 0.0843830838323729 0.544710841322622 mirMAP -0.14327021053209 0.00372994900140062 NA NA NA hsa-miR-29c-3p IKBKG 1.32354490728858 1.84279305179762e-07 0.0843830838323729 0.544710841322622 mirMAP -0.0679540581660154 0.00635176133715187 NA NA NA hsa-miR-330-3p IKBKG -0.716924999893351 0.000796236278616087 0.0843830838323729 0.544710841322622 mirMAP -0.174026313241355 3.45303704238481e-09 NA NA NA hsa-miR-335-5p IKBKG -0.466533891325811 0.0676987038122831 0.0843830838323729 0.544710841322622 mirMAP -0.0931491133227134 0.000880942403573609 NA NA NA hsa-miR-338-5p IKBKG -1.83316380675941 4.03269924759167e-07 0.0843830838323729 0.544710841322622 mirMAP -0.0559723237275578 0.00130481825009543 NA NA NA hsa-miR-141-3p IL1A 3.36993755486106 5.42939251147195e-32 -2.78589291846042 1.94445738122673e-09 MirTarget -0.425166348436577 1.11437754257848e-09 NA NA NA hsa-miR-181c-5p IL1A 0.529875814537156 0.0125885822998008 -2.78589291846042 1.94445738122673e-09 MirTarget -0.41989445653036 3.99923207839548e-05 NA NA NA hsa-miR-181d-5p IL1A 1.19058140522592 8.5908558852417e-09 -2.78589291846042 1.94445738122673e-09 MirTarget -0.495373056794971 1.57350244087555e-06 NA NA NA hsa-miR-200a-3p IL1A 3.14766878548496 1.32850889777422e-21 -2.78589291846042 1.94445738122673e-09 MirTarget -0.451074234294195 9.33609082814678e-13 NA NA NA hsa-miR-30b-5p IL1A 0.358144314839612 0.138026229059594 -2.78589291846042 1.94445738122673e-09 MirTarget -0.372796563568777 3.38432266671698e-05 NA NA NA hsa-miR-30d-5p IL1A -0.920901858717441 3.50898334321668e-05 -2.78589291846042 1.94445738122673e-09 MirTarget -0.356697596588321 0.000238401377855495 NA NA NA hsa-miR-30e-5p IL1A 1.60414100786743 3.78951090573667e-19 -2.78589291846042 1.94445738122673e-09 MirTarget -0.387129646844589 0.000947181744027959 NA NA NA hsa-miR-335-5p IL1A -0.466533891325811 0.0676987038122831 -2.78589291846042 1.94445738122673e-09 miRNAWalker2_validate -0.363571202142101 0.000134067450135358 NA NA NA hsa-miR-664a-3p IL1A 0.443077463053857 0.0214248925850984 -2.78589291846042 1.94445738122673e-09 MirTarget -0.399970970989528 0.000411462536175719 NA NA NA hsa-miR-21-5p IL1B 4.38165933891779 1.52536633902505e-92 -1.4197099567083 1.3846626069017e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.134391564023665 0.0201828525145957 NA NA NA hsa-miR-30d-3p IL1B 0.00396376345349925 0.986457040013182 -1.4197099567083 1.3846626069017e-05 MirTarget -0.185546241965733 0.0112697160369794 NA NA NA hsa-miR-7-1-3p IL1B 2.61364240402652 1.98959237815786e-32 -1.4197099567083 1.3846626069017e-05 MirTarget -0.204885242824381 0.00248885388859552 NA NA NA hsa-miR-130b-5p IL1R1 1.53645187062942 1.10498816261505e-08 -0.902036062273456 1.24728661303111e-05 mirMAP -0.20947298252971 1.38476702999555e-09 NA NA NA hsa-miR-17-3p IL1R1 1.36706429551147 4.60388403547821e-13 -0.902036062273456 1.24728661303111e-05 mirMAP -0.291254110034348 2.75619676884419e-09 NA NA NA hsa-miR-186-5p IL1R1 0.852175445703945 6.88885738584309e-10 -0.902036062273456 1.24728661303111e-05 mirMAP -0.330097048462088 1.4514081890525e-06 NA NA NA hsa-miR-192-5p IL1R1 2.03412119423736 1.6357945826287e-05 -0.902036062273456 1.24728661303111e-05 miRNAWalker2_validate -0.0789518083279709 7.94397332043031e-05 NA NA NA hsa-miR-26b-5p IL1R1 0.72362441215247 4.7794659748036e-05 -0.902036062273456 1.24728661303111e-05 mirMAP -0.151138951739801 0.00500687907349492 NA NA NA hsa-miR-335-3p IL1R1 1.51116383169018 6.88553098788624e-13 -0.902036062273456 1.24728661303111e-05 mirMAP -0.292160492099576 2.30254080656226e-11 NA NA NA hsa-miR-361-5p IL1R1 0.21454431962475 0.0800957579368424 -0.902036062273456 1.24728661303111e-05 miRanda -0.202848902425797 0.0110414646766357 NA NA NA hsa-miR-590-3p IL1R1 0.83851360565783 0.00129224433453587 -0.902036062273456 1.24728661303111e-05 miRanda;miRNATAP -0.166712189356744 0.00014487477422078 NA NA NA hsa-miR-106a-5p IL1RAP 1.3902608059488 6.07931522284525e-05 0.000245152751386257 0.999187506373076 MirTarget -0.0915767351906464 0.00978173329794503 NA NA NA hsa-miR-129-5p IL1RAP -0.405735314747643 0.341485636033577 0.000245152751386257 0.999187506373076 miRanda -0.0934639052917333 0.000324126184200782 NA NA NA hsa-miR-139-5p IL1RAP -2.26625553116965 7.22375119369519e-16 0.000245152751386257 0.999187506373076 miRanda -0.118443639544596 0.00188256138463295 NA NA NA hsa-miR-16-1-3p IL1RAP 1.50034693398929 6.63958242991125e-10 0.000245152751386257 0.999187506373076 mirMAP -0.140048006210677 0.0120173981404929 NA NA NA hsa-miR-17-5p IL1RAP 2.07078488653279 2.77403038572568e-19 0.000245152751386257 0.999187506373076 MirTarget;TargetScan -0.201324308672122 1.15234440604181e-05 NA NA NA hsa-miR-186-5p IL1RAP 0.852175445703945 6.88885738584309e-10 0.000245152751386257 0.999187506373076 mirMAP -0.220997757431585 0.00560235433690743 NA NA NA hsa-miR-192-5p IL1RAP 2.03412119423736 1.6357945826287e-05 0.000245152751386257 0.999187506373076 miRNAWalker2_validate -0.0775751169010724 0.000808464051221588 NA NA NA hsa-miR-19a-3p IL1RAP 2.11776595911517 7.07663078397156e-10 0.000245152751386257 0.999187506373076 MirTarget -0.204065274766844 4.68860420392829e-08 NA NA NA hsa-miR-19b-3p IL1RAP 2.10868505662119 5.40846613768389e-17 0.000245152751386257 0.999187506373076 MirTarget -0.227644553615202 2.9123960861649e-07 NA NA NA hsa-miR-204-5p IL1RAP -1.01965803752657 0.00767207541525746 0.000245152751386257 0.999187506373076 miRNAWalker2_validate -0.108955560529284 0.000176986072537337 NA NA NA hsa-miR-20a-5p IL1RAP 2.64649625616975 5.1469418982085e-27 0.000245152751386257 0.999187506373076 MirTarget -0.207167611000991 8.81529955413445e-07 NA NA NA hsa-miR-215-5p IL1RAP 0.116505586532384 0.8384722675454 0.000245152751386257 0.999187506373076 miRNAWalker2_validate -0.0563196813472185 0.0118515126278079 NA NA NA hsa-miR-217 IL1RAP 1.88358668330143 3.93795605235061e-07 0.000245152751386257 0.999187506373076 miRanda -0.0745665967072774 0.0195771598366048 NA NA NA hsa-miR-29a-3p IL1RAP 0.101650412194573 0.573201097011668 0.000245152751386257 0.999187506373076 MirTarget;miRNATAP -0.191769017989552 0.00191288163853844 NA NA NA hsa-miR-29b-3p IL1RAP 3.10527711861309 3.01242507282711e-32 0.000245152751386257 0.999187506373076 MirTarget;miRNATAP -0.204557456978232 1.41972422604361e-07 NA NA NA hsa-miR-29c-3p IL1RAP 1.32354490728858 1.84279305179762e-07 0.000245152751386257 0.999187506373076 MirTarget;miRNATAP -0.168567921542829 8.63855866890971e-05 NA NA NA hsa-miR-362-3p IL1RAP 0.194097672030785 0.52808475179225 0.000245152751386257 0.999187506373076 miRanda -0.0925345981244769 0.0404187960440372 NA NA NA hsa-miR-375 IL1RAP 0.615547997686534 0.149199273675144 0.000245152751386257 0.999187506373076 miRNAWalker2_validate;miRanda -0.142709680140902 2.39984635102537e-08 NA NA NA hsa-miR-454-3p IL1RAP 1.49453641052169 4.46235742871434e-09 0.000245152751386257 0.999187506373076 MirTarget -0.13278942771255 0.00959574339052586 NA NA NA hsa-miR-576-5p IL1RAP 1.02693643167056 1.14846964470173e-06 0.000245152751386257 0.999187506373076 mirMAP -0.150524986290784 0.00382112305947481 NA NA NA hsa-miR-582-5p IL1RAP 1.08286181406653 0.00149040450161757 0.000245152751386257 0.999187506373076 MirTarget -0.139501140069638 2.33773623468932e-05 NA NA NA hsa-miR-664a-3p IL1RAP 0.443077463053857 0.0214248925850984 0.000245152751386257 0.999187506373076 mirMAP -0.152730147384317 0.00816289760017588 NA NA NA hsa-miR-7-1-3p IL1RAP 2.61364240402652 1.98959237815786e-32 0.000245152751386257 0.999187506373076 MirTarget -0.125460645664714 0.0112093164942368 NA NA NA hsa-miR-93-5p IL1RAP 1.50844106515467 1.83836866996875e-12 0.000245152751386257 0.999187506373076 MirTarget -0.112688886804948 0.0262344005966696 NA NA NA hsa-miR-95-3p IL1RAP -0.191519075333182 0.533735544214583 0.000245152751386257 0.999187506373076 MirTarget -0.132874977071657 0.000340944679739554 NA NA NA hsa-miR-125a-3p IRAK1 -1.04954492275266 2.45974219476832e-06 1.11249641990519 7.42189849563542e-14 miRanda -0.0845538305812045 0.00698585004038421 NA NA NA hsa-miR-146a-5p IRAK1 0.684701497250824 0.0105316554224149 1.11249641990519 7.42189849563542e-14 miRNAWalker2_validate;miRTarBase -0.101832573808984 0.000147555897647003 25242818;22846912;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;Functional analysis revealed that miR-146a rs2910164 C allele inhibited cell proliferation and significantly downregulated expression of IRAK1 and TRAF6 in bladder cancer cells;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;; pancreatic cancer;bladder cancer;gastric cancer hsa-miR-335-5p IRAK2 -0.466533891325811 0.0676987038122831 0.567287186290348 0.0152967123507346 miRNAWalker2_validate -0.16550007553947 0.00045872865745022 NA NA NA hsa-miR-141-3p IRAK3 3.36993755486106 5.42939251147195e-32 -1.31653047867367 9.84276567820939e-06 mirMAP -0.146294779355006 0.00115134062341314 NA NA NA hsa-miR-20a-3p IRAK3 2.51803599558247 4.92479325298629e-13 -1.31653047867367 9.84276567820939e-06 mirMAP -0.187141915295028 0.000174865553791266 NA NA NA hsa-miR-21-5p IRAK3 4.38165933891779 1.52536633902505e-92 -1.31653047867367 9.84276567820939e-06 mirMAP -0.201892704895579 0.000120101491819665 NA NA NA hsa-miR-25-3p IRAK3 0.361927330834176 0.0163670566170988 -1.31653047867367 9.84276567820939e-06 mirMAP -0.239604432744736 0.00982482842095353 NA NA NA hsa-miR-3200-3p IRAK3 0.521712783553188 0.134990592651885 -1.31653047867367 9.84276567820939e-06 mirMAP -0.147424016420393 0.000299400692988312 NA NA NA hsa-miR-324-5p IRAK3 1.06955541886548 5.39722006604758e-05 -1.31653047867367 9.84276567820939e-06 miRanda -0.138862111225755 0.00751997615275624 NA NA NA hsa-miR-335-3p IRAK3 1.51116383169018 6.88553098788624e-13 -1.31653047867367 9.84276567820939e-06 mirMAP -0.447288987971565 1.16142984363208e-12 NA NA NA hsa-miR-33a-5p IRAK3 2.80127809675219 5.09053890529424e-12 -1.31653047867367 9.84276567820939e-06 mirMAP -0.129087503700998 0.00174107996862328 NA NA NA hsa-miR-421 IRAK3 0.170525317701774 0.535277026680289 -1.31653047867367 9.84276567820939e-06 miRanda;mirMAP -0.132796225968858 0.0154793959682764 NA NA NA hsa-miR-429 IRAK3 2.3794516574089 1.72813419703734e-13 -1.31653047867367 9.84276567820939e-06 miRanda -0.0938962755007273 0.038277501339057 NA NA NA hsa-miR-450b-5p IRAK3 1.69248953402469 1.96052058003353e-07 -1.31653047867367 9.84276567820939e-06 mirMAP -0.176423483699516 0.000163748438267334 NA NA NA hsa-miR-452-3p IRAK3 0.477736876273128 0.22218404598603 -1.31653047867367 9.84276567820939e-06 mirMAP -0.0930962996748465 0.023876640172529 NA NA NA hsa-miR-501-5p IRAK3 0.411357595674671 0.10435288464149 -1.31653047867367 9.84276567820939e-06 mirMAP -0.115229192234932 0.0356103577466442 NA NA NA hsa-miR-589-3p IRAK3 1.34253876396688 1.84935927493927e-05 -1.31653047867367 9.84276567820939e-06 mirMAP -0.129315117987875 0.00422615870683415 NA NA NA hsa-miR-590-5p IRAK3 2.07441240363458 4.95240551694843e-14 -1.31653047867367 9.84276567820939e-06 mirMAP -0.230007167814281 0.000144934857159697 NA NA NA hsa-miR-660-5p IRAK3 2.04875198906126 1.08269480928897e-17 -1.31653047867367 9.84276567820939e-06 mirMAP -0.132393087948539 0.0211062757131547 NA NA NA hsa-miR-129-5p IRAK4 -0.405735314747643 0.341485636033577 0.222767755953482 0.0289927874328376 miRanda -0.053385842932338 1.02082941706101e-06 NA NA NA hsa-miR-30d-3p IRAK4 0.00396376345349925 0.986457040013182 0.222767755953482 0.0289927874328376 mirMAP -0.0669083902463306 0.00298837433386243 NA NA NA hsa-miR-320a IRAK4 -0.961144925954715 1.62478794429204e-08 0.222767755953482 0.0289927874328376 miRanda -0.0579742218115092 0.033929735071356 NA NA NA hsa-miR-106b-5p MAP3K14 1.47447672652218 1.32004094930462e-13 -0.508395608018966 0.005388667824716 MirTarget -0.148081791172922 0.000331285249363202 NA NA NA hsa-miR-17-3p MAP3K14 1.36706429551147 4.60388403547821e-13 -0.508395608018966 0.005388667824716 MirTarget -0.160398561527579 0.000231985049439229 NA NA NA hsa-miR-345-5p MAP3K14 1.48924745604581 1.54134850666509e-06 -0.508395608018966 0.005388667824716 MirTarget -0.071022946698794 0.00830151965984703 NA NA NA hsa-miR-429 MAP3K14 2.3794516574089 1.72813419703734e-13 -0.508395608018966 0.005388667824716 miRNATAP -0.0859719578303261 0.00177860224565349 NA NA NA hsa-miR-330-5p MYD88 0.168520831101569 0.336433937906706 -0.587709074735129 7.43383821392277e-07 MirTarget;miRanda -0.0721839913219897 0.0230129735048345 NA NA NA hsa-miR-365a-3p MYD88 0.0132777124336201 0.953597412537431 -0.587709074735129 7.43383821392277e-07 MirTarget -0.123020139940839 3.03625517446058e-07 NA NA NA hsa-miR-429 MYD88 2.3794516574089 1.72813419703734e-13 -0.587709074735129 7.43383821392277e-07 miRanda -0.113048835976415 1.68777256167566e-10 NA NA NA hsa-miR-660-5p MYD88 2.04875198906126 1.08269480928897e-17 -0.587709074735129 7.43383821392277e-07 MirTarget -0.0775915720778061 0.000660216863713234 NA NA NA hsa-miR-21-5p NFKB1 4.38165933891779 1.52536633902505e-92 -0.340270335589995 0.00609383891055805 miRNAWalker2_validate -0.0513270109059431 0.0183291819603586 19559015 We further identified and validated LRRFIP1 whose product is an inhibitor of NF-kappaB signaling as a direct target gene of miR-21 glioblastoma hsa-miR-210-3p NFKB1 4.89285936864822 4.81769290932762e-28 -0.340270335589995 0.00609383891055805 miRNAWalker2_validate -0.0541473175826376 5.78818642221287e-06 NA NA NA hsa-miR-26b-5p NFKB1 0.72362441215247 4.7794659748036e-05 -0.340270335589995 0.00609383891055805 miRNAWalker2_validate -0.0924126208136336 0.00395240571514127 NA NA NA hsa-miR-429 NFKB1 2.3794516574089 1.72813419703734e-13 -0.340270335589995 0.00609383891055805 miRanda;miRNATAP -0.0745930074888861 5.92229415203977e-05 NA NA NA hsa-miR-450b-5p NFKB1 1.69248953402469 1.96052058003353e-07 -0.340270335589995 0.00609383891055805 MirTarget;PITA -0.0685283097853144 0.000390218949665653 NA NA NA hsa-miR-590-3p NFKB1 0.83851360565783 0.00129224433453587 -0.340270335589995 0.00609383891055805 miRanda;mirMAP -0.0749518628379661 0.00425440292177732 24200043 We identified important regulators MYC NFKB1 miR-590 and miR-570 and significant miRNA-TF synergistic regulatory motifs by random simulations lung squamous cell cancer hsa-miR-671-5p NFKB1 2.24156654191798 2.10433241567652e-14 -0.340270335589995 0.00609383891055805 MirTarget -0.104865468815509 3.02257267140541e-06 NA NA NA hsa-miR-9-5p NFKB1 4.99250901331516 2.59132733422801e-19 -0.340270335589995 0.00609383891055805 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.05570554718554 9.49586318708835e-09 NA NA NA hsa-miR-143-5p NFKBIA 1.86670676070774 1.06290100545251e-09 -0.983254671535957 2.73270781474523e-07 MirTarget -0.0784283825876107 0.00609138122074943 NA NA NA hsa-let-7b-5p NGF -1.62016148171663 1.56547487335694e-15 0.201813000750518 0.680403675107959 MirTarget -0.242858337482323 0.0246273998823271 NA NA NA hsa-miR-320a NGF -0.961144925954715 1.62478794429204e-08 0.201813000750518 0.680403675107959 miRanda -0.306575920656902 0.0199126531419783 NA NA NA hsa-miR-320b NGF 0.226640952564488 0.378818692487242 0.201813000750518 0.680403675107959 miRanda -0.175428791274416 0.0460777091944554 NA NA NA hsa-miR-185-3p NTRK1 -0.377490365509078 0.093653288903368 -1.20191019732804 0.000181518709629851 MirTarget -0.220344116634979 0.000867618792014595 NA NA NA hsa-miR-146b-5p PIK3CA 1.0922867893808 5.63754607494775e-06 -0.335143841150832 0.0107695904000801 mirMAP -0.0583472413360436 0.0194987620121081 NA NA NA hsa-miR-148b-3p PIK3CA 0.483970528590224 0.0026495409465901 -0.335143841150832 0.0107695904000801 miRNAWalker2_validate -0.0928283701395613 0.014143048610305 NA NA NA hsa-miR-17-5p PIK3CA 2.07078488653279 2.77403038572568e-19 -0.335143841150832 0.0107695904000801 miRNAWalker2_validate -0.0882011635633729 0.000457527124021159 NA NA NA hsa-miR-186-5p PIK3CA 0.852175445703945 6.88885738584309e-10 -0.335143841150832 0.0107695904000801 mirMAP -0.158211833933772 0.000271764939125213 NA NA NA hsa-miR-200b-3p PIK3CA 1.55157578247391 4.83790020897188e-09 -0.335143841150832 0.0107695904000801 TargetScan -0.0815259473611161 0.000271549438004817 NA NA NA hsa-miR-29b-1-5p PIK3CA 1.71024742617744 3.64915691793611e-09 -0.335143841150832 0.0107695904000801 mirMAP -0.0934376245047679 4.48970598013989e-06 NA NA NA hsa-miR-339-5p PIK3CA 0.536997313601114 0.0488090394176611 -0.335143841150832 0.0107695904000801 miRanda -0.0830170071359709 0.000174379012940868 NA NA NA hsa-miR-501-5p PIK3CA 0.411357595674671 0.10435288464149 -0.335143841150832 0.0107695904000801 mirMAP -0.12161859871495 2.80222388365699e-07 NA NA NA hsa-miR-590-5p PIK3CA 2.07441240363458 4.95240551694843e-14 -0.335143841150832 0.0107695904000801 miRanda -0.0581233004804079 0.0287847129352189 NA NA NA hsa-miR-96-5p PIK3CA 3.0381097138467 4.40362891630201e-24 -0.335143841150832 0.0107695904000801 TargetScan -0.126074442438012 7.26672594996813e-09 NA NA NA hsa-miR-126-5p PIK3CB 0.851637714492907 0.000391373420568359 0.0520424688078016 0.708498300848208 mirMAP -0.0605145487990616 0.0226139115577761 NA NA NA hsa-miR-130a-3p PIK3CB 0.881660100597014 0.000158893668519248 0.0520424688078016 0.708498300848208 miRNATAP -0.0973143239451141 0.000343594807690165 NA NA NA hsa-miR-199b-3p PIK3CB 1.67802185853505 6.03525898173555e-15 0.0520424688078016 0.708498300848208 miRNATAP -0.093536269278395 0.00118998138613454 NA NA NA hsa-miR-19a-3p PIK3CB 2.11776595911517 7.07663078397156e-10 0.0520424688078016 0.708498300848208 miRNATAP -0.0774654945704452 0.000368260914438548 NA NA NA hsa-miR-19b-3p PIK3CB 2.10868505662119 5.40846613768389e-17 0.0520424688078016 0.708498300848208 miRNATAP -0.0572309726626399 0.0271242306078405 NA NA NA hsa-miR-214-3p PIK3CB -1.1136198715556 3.52054933799089e-05 0.0520424688078016 0.708498300848208 miRNATAP -0.0699628164662502 0.00300173944217655 NA NA NA hsa-miR-301a-3p PIK3CB 2.70198002906399 1.56420889710984e-14 0.0520424688078016 0.708498300848208 miRNATAP -0.0535393267236453 0.0144058369394699 NA NA NA hsa-miR-454-3p PIK3CB 1.49453641052169 4.46235742871434e-09 0.0520424688078016 0.708498300848208 miRNATAP -0.107092855274913 0.000279808925292599 NA NA NA hsa-miR-590-3p PIK3CB 0.83851360565783 0.00129224433453587 0.0520424688078016 0.708498300848208 miRNATAP -0.0585639579148209 0.0463244879285181 NA NA NA hsa-miR-421 PIK3CD 0.170525317701774 0.535277026680289 -0.165252183051274 0.400815192488832 miRanda -0.187035284767016 1.2803934448503e-07 NA NA NA hsa-miR-7-5p PIK3CD 0.343825848926135 0.435063427976906 -0.165252183051274 0.400815192488832 miRTarBase;MirTarget;miRNATAP -0.0875241809079012 0.000620982800140571 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-148b-3p PIK3CG 0.483970528590224 0.0026495409465901 -1.19325793461087 5.28114748039233e-05 miRNAWalker2_validate -0.239430332797948 0.00515332606189168 NA NA NA hsa-miR-26b-5p PIK3CG 0.72362441215247 4.7794659748036e-05 -1.19325793461087 5.28114748039233e-05 miRNAWalker2_validate -0.285401672500096 0.000198071700272844 NA NA NA hsa-miR-29b-3p PIK3CG 3.10527711861309 3.01242507282711e-32 -1.19325793461087 5.28114748039233e-05 miRTarBase -0.13454994451672 0.00563635188925694 NA NA NA hsa-miR-335-3p PIK3CG 1.51116383169018 6.88553098788624e-13 -1.19325793461087 5.28114748039233e-05 mirMAP -0.273824058387904 1.51960031354635e-05 NA NA NA hsa-miR-542-3p PIK3CG 1.62226640768239 2.6427102465476e-10 -1.19325793461087 5.28114748039233e-05 miRanda -0.188110029792226 0.000315799878113487 NA NA NA hsa-miR-106a-5p PIK3R1 1.3902608059488 6.07931522284525e-05 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.152594260668069 8.26964346589391e-10 NA NA NA hsa-miR-106b-5p PIK3R1 1.47447672652218 1.32004094930462e-13 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.274486784039244 3.92361901886501e-13 NA NA NA hsa-miR-107 PIK3R1 0.658676029898313 5.11480446318819e-07 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda;miRNATAP -0.134608742116129 0.0261488734968106 NA NA NA hsa-miR-128-3p PIK3R1 1.03509868349735 2.11606310588315e-10 -1.28526113405546 1.1596112892202e-14 MirTarget -0.262733562571172 2.81828198129055e-08 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 0.845987603184611 0.000579808501723616 -1.28526113405546 1.1596112892202e-14 MirTarget -0.252566507630763 3.89638206850943e-16 NA NA NA hsa-miR-15a-5p PIK3R1 1.62575353599172 1.55312121019827e-19 -1.28526113405546 1.1596112892202e-14 MirTarget -0.198845640675418 2.2459439580454e-06 NA NA NA hsa-miR-16-2-3p PIK3R1 0.503964803530872 0.0263648405197492 -1.28526113405546 1.1596112892202e-14 MirTarget -0.215346374588015 7.85659740371802e-09 NA NA NA hsa-miR-16-5p PIK3R1 0.749619098384047 4.11649450706988e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.14663084031301 0.00245632583144358 NA NA NA hsa-miR-17-5p PIK3R1 2.07078488653279 2.77403038572568e-19 -1.28526113405546 1.1596112892202e-14 MirTarget;TargetScan;miRNATAP -0.30827377198364 1.00416866782136e-22 NA NA NA hsa-miR-182-5p PIK3R1 3.21839823004635 5.13049145201115e-39 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.153577568348738 1.31399000956901e-07 NA NA NA hsa-miR-185-5p PIK3R1 1.14291034858482 2.95777119743491e-13 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.266123472564886 5.49627003455298e-08 NA NA NA hsa-miR-186-5p PIK3R1 0.852175445703945 6.88885738584309e-10 -1.28526113405546 1.1596112892202e-14 mirMAP -0.266496146428416 2.3226235073163e-06 NA NA NA hsa-miR-200c-3p PIK3R1 0.380533388300368 0.0842181838538353 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174738637328334 9.22364461849854e-07 NA NA NA hsa-miR-20a-5p PIK3R1 2.64649625616975 5.1469418982085e-27 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.268255645046992 2.93530513676098e-20 NA NA NA hsa-miR-20b-5p PIK3R1 1.35770573270947 0.00260808530013016 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.067165543379522 0.000243466393889195 NA NA NA hsa-miR-21-5p PIK3R1 4.38165933891779 1.52536633902505e-92 -1.28526113405546 1.1596112892202e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.239855941401679 1.66617444081141e-16 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 1.71436244278242 9.85038001236064e-15 -1.28526113405546 1.1596112892202e-14 mirMAP -0.249170402831725 1.77307790115702e-13 NA NA NA hsa-miR-29b-3p PIK3R1 3.10527711861309 3.01242507282711e-32 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.169264704761152 8.1620915503371e-10 NA NA NA hsa-miR-320b PIK3R1 0.226640952564488 0.378818692487242 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.0840021785596869 0.00624378807120238 NA NA NA hsa-miR-335-3p PIK3R1 1.51116383169018 6.88553098788624e-13 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174731000503181 1.56931158200611e-06 NA NA NA hsa-miR-3607-3p PIK3R1 2.4103172144469 2.69039449048047e-08 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.053108775645446 0.00298459574421202 NA NA NA hsa-miR-374a-3p PIK3R1 1.73882813668241 1.57901646296214e-13 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.0681540502229108 0.0372663655827778 NA NA NA hsa-miR-424-5p PIK3R1 1.26485330287919 6.1498991028257e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.120660860108298 1.41199550729587e-05 NA NA NA hsa-miR-429 PIK3R1 2.3794516574089 1.72813419703734e-13 -1.28526113405546 1.1596112892202e-14 mirMAP;miRNATAP -0.0946153444641291 0.000232563327969414 NA NA NA hsa-miR-450b-5p PIK3R1 1.69248953402469 1.96052058003353e-07 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.105483872062601 7.60035078150308e-05 NA NA NA hsa-miR-542-3p PIK3R1 1.62226640768239 2.6427102465476e-10 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda -0.0765091781412023 0.0112798132172847 NA NA NA hsa-miR-582-5p PIK3R1 1.08286181406653 0.00149040450161757 -1.28526113405546 1.1596112892202e-14 mirMAP -0.121659359408152 1.98808465862233e-07 NA NA NA hsa-miR-589-3p PIK3R1 1.34253876396688 1.84935927493927e-05 -1.28526113405546 1.1596112892202e-14 mirMAP -0.110115880585781 1.73041185531321e-05 NA NA NA hsa-miR-590-3p PIK3R1 0.83851360565783 0.00129224433453587 -1.28526113405546 1.1596112892202e-14 miRanda;mirMAP -0.21433969556349 1.93094554722457e-09 NA NA NA hsa-miR-590-5p PIK3R1 2.07441240363458 4.95240551694843e-14 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda;miRNATAP -0.297606057222883 4.39734655384069e-19 NA NA NA hsa-miR-629-3p PIK3R1 1.31892116211001 0.000114487182853678 -1.28526113405546 1.1596112892202e-14 MirTarget -0.155200085033098 2.2200629415611e-10 NA NA NA hsa-miR-93-5p PIK3R1 1.50844106515467 1.83836866996875e-12 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.302548872464343 3.62432128460294e-18 NA NA NA hsa-miR-96-5p PIK3R1 3.0381097138467 4.40362891630201e-24 -1.28526113405546 1.1596112892202e-14 TargetScan;miRNATAP -0.247820034174453 4.28366535969023e-19 NA NA NA hsa-miR-423-5p PIK3R2 -1.80309342242719 1.34791344187441e-19 0.48327969760863 0.00012392613055861 MirTarget -0.0591712734717364 0.0359292764910396 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.71024742617744 3.64915691793611e-09 -0.993075734580867 1.37876508579496e-06 mirMAP -0.137607471527013 2.02669327816331e-05 NA NA NA hsa-miR-3065-5p PIK3R3 0.653308707552535 0.0999497219778851 -0.993075734580867 1.37876508579496e-06 mirMAP;miRNATAP -0.0584048364096984 0.025988738431942 NA NA NA hsa-miR-335-3p PIK3R3 1.51116383169018 6.88553098788624e-13 -0.993075734580867 1.37876508579496e-06 mirMAP -0.239450639911665 5.21180596069304e-08 NA NA NA hsa-miR-375 PIK3R3 0.615547997686534 0.149199273675144 -0.993075734580867 1.37876508579496e-06 miRanda -0.0733589923077402 0.00103194265456189 NA NA NA hsa-miR-582-5p PIK3R3 1.08286181406653 0.00149040450161757 -0.993075734580867 1.37876508579496e-06 PITA -0.0729772035242806 0.010974848433229 NA NA NA hsa-miR-107 PIK3R5 0.658676029898313 5.11480446318819e-07 -1.41857329052665 4.9150449517908e-09 miRanda -0.303365993068523 0.000471196296141979 NA NA NA hsa-miR-182-5p PIK3R5 3.21839823004635 5.13049145201115e-39 -1.41857329052665 4.9150449517908e-09 MirTarget -0.327566926397612 1.58877421029473e-15 NA NA NA hsa-miR-106a-5p PPP3CA 1.3902608059488 6.07931522284525e-05 -0.313973239016408 0.0165177462343014 miRNATAP -0.133933104567234 1.19345709173472e-12 NA NA NA hsa-miR-106b-5p PPP3CA 1.47447672652218 1.32004094930462e-13 -0.313973239016408 0.0165177462343014 miRNATAP -0.0899225338524375 0.00233780389963004 NA NA NA hsa-miR-142-3p PPP3CA 3.98476449801341 1.56256182021111e-35 -0.313973239016408 0.0165177462343014 miRNATAP -0.118826172048727 2.75854825586705e-12 NA NA NA hsa-miR-142-5p PPP3CA 1.29672439149353 4.0768822158894e-06 -0.313973239016408 0.0165177462343014 PITA;mirMAP;miRNATAP -0.0826900574461858 0.000314805322156559 NA NA NA hsa-miR-17-5p PPP3CA 2.07078488653279 2.77403038572568e-19 -0.313973239016408 0.0165177462343014 miRNATAP -0.176015588845375 7.62312188608765e-13 NA NA NA hsa-miR-186-5p PPP3CA 0.852175445703945 6.88885738584309e-10 -0.313973239016408 0.0165177462343014 mirMAP -0.286847992743368 1.57472937315132e-11 NA NA NA hsa-miR-194-5p PPP3CA 1.76979641760284 8.2064222072696e-05 -0.313973239016408 0.0165177462343014 MirTarget -0.0701750916982925 9.24352716707214e-08 NA NA NA hsa-miR-20a-5p PPP3CA 2.64649625616975 5.1469418982085e-27 -0.313973239016408 0.0165177462343014 miRNATAP -0.154552998486965 9.11892644521842e-12 NA NA NA hsa-miR-20b-5p PPP3CA 1.35770573270947 0.00260808530013016 -0.313973239016408 0.0165177462343014 miRNATAP -0.122294666346707 1.15249428256532e-19 NA NA NA hsa-miR-21-5p PPP3CA 4.38165933891779 1.52536633902505e-92 -0.313973239016408 0.0165177462343014 miRNATAP -0.0536296752494887 0.0195015440795713 NA NA NA hsa-miR-29a-5p PPP3CA 1.89519956688438 1.03453349363915e-11 -0.313973239016408 0.0165177462343014 mirMAP;miRNATAP -0.0859325774490469 0.000666820324004006 NA NA NA hsa-miR-30c-5p PPP3CA -0.327319105755825 0.123595832152687 -0.313973239016408 0.0165177462343014 miRNATAP -0.10873673306536 0.000125286600086868 NA NA NA hsa-miR-320b PPP3CA 0.226640952564488 0.378818692487242 -0.313973239016408 0.0165177462343014 miRanda -0.0758539112116975 0.00119663860840408 NA NA NA hsa-miR-335-3p PPP3CA 1.51116383169018 6.88553098788624e-13 -0.313973239016408 0.0165177462343014 MirTarget -0.0918718077862827 0.00101750220514367 NA NA NA hsa-miR-3607-3p PPP3CA 2.4103172144469 2.69039449048047e-08 -0.313973239016408 0.0165177462343014 MirTarget;mirMAP;miRNATAP -0.0508633923122833 0.000187707963390673 NA NA NA hsa-miR-361-3p PPP3CA 0.0988926195529967 0.549128728500555 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.173641727258806 2.07130127414673e-06 NA NA NA hsa-miR-374b-3p PPP3CA -0.157526212601818 0.538677664999491 -0.313973239016408 0.0165177462343014 MirTarget -0.0970178877180317 0.000684669202606805 NA NA NA hsa-miR-450b-5p PPP3CA 1.69248953402469 1.96052058003353e-07 -0.313973239016408 0.0165177462343014 PITA;mirMAP;miRNATAP -0.0517289565703569 0.0114413378762073 NA NA NA hsa-miR-501-3p PPP3CA -0.0405952693028064 0.866802243505833 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.152231773192009 5.82453493976863e-10 NA NA NA hsa-miR-502-3p PPP3CA -0.262270070977708 0.161760375279961 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.102225645893012 0.00155670003675052 NA NA NA hsa-miR-582-5p PPP3CA 1.08286181406653 0.00149040450161757 -0.313973239016408 0.0165177462343014 miRNATAP -0.0709950172375692 7.78846793131083e-05 NA NA NA hsa-miR-589-3p PPP3CA 1.34253876396688 1.84935927493927e-05 -0.313973239016408 0.0165177462343014 MirTarget -0.111512777165905 9.25189699847489e-09 NA NA NA hsa-miR-590-3p PPP3CA 0.83851360565783 0.00129224433453587 -0.313973239016408 0.0165177462343014 miRanda;mirMAP -0.108711400054004 7.97592745451833e-05 NA NA NA hsa-miR-590-5p PPP3CA 2.07441240363458 4.95240551694843e-14 -0.313973239016408 0.0165177462343014 PITA;miRanda;miRNATAP -0.177690930412641 6.75602594094779e-12 NA NA NA hsa-miR-642a-5p PPP3CA 0.788077674970441 0.0303202946051994 -0.313973239016408 0.0165177462343014 MirTarget -0.0727173408580009 1.66402364982025e-05 NA NA NA hsa-miR-664a-3p PPP3CA 0.443077463053857 0.0214248925850984 -0.313973239016408 0.0165177462343014 mirMAP -0.0780660087141385 0.0130137988041591 NA NA NA hsa-miR-7-1-3p PPP3CA 2.61364240402652 1.98959237815786e-32 -0.313973239016408 0.0165177462343014 MirTarget;mirMAP -0.121059394653456 5.88147588879243e-06 NA NA NA hsa-miR-93-3p PPP3CA 1.07631808403007 1.63747525692813e-05 -0.313973239016408 0.0165177462343014 miRNATAP -0.170128744194282 3.50156314525736e-13 NA NA NA hsa-miR-93-5p PPP3CA 1.50844106515467 1.83836866996875e-12 -0.313973239016408 0.0165177462343014 miRNATAP -0.25180151434334 1.28858993768457e-21 NA NA NA hsa-miR-96-5p PPP3CA 3.0381097138467 4.40362891630201e-24 -0.313973239016408 0.0165177462343014 TargetScan -0.0937144882603186 1.85145094260158e-05 NA NA NA hsa-miR-15a-5p PPP3CB 1.62575353599172 1.55312121019827e-19 -0.217161149975175 0.026537796620393 miRNATAP -0.123109224513088 2.45320870406106e-07 NA NA NA hsa-miR-20a-3p PPP3CB 2.51803599558247 4.92479325298629e-13 -0.217161149975175 0.026537796620393 miRNATAP -0.0541726487373894 0.000819374596879857 NA NA NA hsa-miR-30c-5p PPP3CB -0.327319105755825 0.123595832152687 -0.217161149975175 0.026537796620393 miRNATAP -0.117562918064524 1.93721091880072e-08 NA NA NA hsa-miR-339-5p PPP3CB 0.536997313601114 0.0488090394176611 -0.217161149975175 0.026537796620393 miRanda -0.0949241987691464 5.01580087873903e-09 NA NA NA hsa-miR-342-3p PPP3CB -0.128691966564961 0.561034080130801 -0.217161149975175 0.026537796620393 miRanda -0.087205267796052 1.6479607706238e-05 NA NA NA hsa-miR-361-5p PPP3CB 0.21454431962475 0.0800957579368424 -0.217161149975175 0.026537796620393 miRanda -0.127974103120468 0.000592380004256261 NA NA NA hsa-miR-450b-5p PPP3CB 1.69248953402469 1.96052058003353e-07 -0.217161149975175 0.026537796620393 MirTarget;PITA;miRNATAP -0.0713053210561693 2.359150993265e-06 NA NA NA hsa-miR-497-5p PPP3CB -0.0546347378264729 0.786205564901684 -0.217161149975175 0.026537796620393 miRNATAP -0.0521919661742656 0.0200429759563575 NA NA NA hsa-miR-501-5p PPP3CB 0.411357595674671 0.10435288464149 -0.217161149975175 0.026537796620393 PITA;miRNATAP -0.0822878199988805 2.97423457752005e-06 NA NA NA hsa-miR-7-1-3p PPP3CB 2.61364240402652 1.98959237815786e-32 -0.217161149975175 0.026537796620393 mirMAP -0.0682306348429503 0.00064476038486064 NA NA NA hsa-miR-361-5p PPP3CC 0.21454431962475 0.0800957579368424 -0.864879436917075 5.11810186256782e-12 miRanda -0.162282770575647 0.000912467378574366 NA NA NA hsa-miR-139-5p PPP3R1 -2.26625553116965 7.22375119369519e-16 -0.021451907795778 0.828812244123992 miRanda -0.0791159416033067 3.20456777136532e-07 NA NA NA hsa-miR-143-5p PPP3R1 1.86670676070774 1.06290100545251e-09 -0.021451907795778 0.828812244123992 miRNATAP -0.0512409896267209 0.000415050392478234 NA NA NA hsa-miR-181a-5p PPP3R1 -0.375429731222937 0.0562142867129802 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.174665544764319 9.40491398689482e-15 NA NA NA hsa-miR-181b-5p PPP3R1 0.668793269169928 0.000239998092406404 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.114349020464675 3.84750784901666e-06 NA NA NA hsa-miR-181c-5p PPP3R1 0.529875814537156 0.0125885822998008 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.106737924157465 4.8061231789594e-07 NA NA NA hsa-miR-204-5p PPP3R1 -1.01965803752657 0.00767207541525746 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.0603712180788161 3.34890394795728e-07 NA NA NA hsa-miR-221-3p PPP3R1 -0.0986794612964683 0.654454148658401 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.0545090307196381 0.0083917643716636 NA NA NA hsa-miR-222-3p PPP3R1 0.0327210697409583 0.881937768109611 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.0796292109835601 0.000111512113960767 NA NA NA hsa-miR-27a-3p PPP3R1 0.433402568013802 0.00737164631768323 -0.021451907795778 0.828812244123992 miRNATAP -0.062540284396491 0.0270698263386403 NA NA NA hsa-miR-27b-3p PPP3R1 0.236438984240408 0.12263510345883 -0.021451907795778 0.828812244123992 miRNATAP -0.122284709618602 4.10399666262129e-05 NA NA NA hsa-miR-30a-5p PPP3R1 -0.924084264430689 0.000762030454634728 -0.021451907795778 0.828812244123992 miRNAWalker2_validate;MirTarget;miRNATAP -0.0649274186033407 7.45421791752148e-05 NA NA NA hsa-miR-30b-5p PPP3R1 0.358144314839612 0.138026229059594 -0.021451907795778 0.828812244123992 MirTarget -0.109418887183495 3.74739901258502e-09 NA NA NA hsa-miR-30c-5p PPP3R1 -0.327319105755825 0.123595832152687 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.157231202749467 5.03548982239333e-14 NA NA NA hsa-miR-30d-5p PPP3R1 -0.920901858717441 3.50898334321668e-05 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.081096597016787 5.94463652738889e-05 NA NA NA hsa-miR-30e-5p PPP3R1 1.60414100786743 3.78951090573667e-19 -0.021451907795778 0.828812244123992 MirTarget -0.0663189985907219 0.00667218247502014 NA NA NA hsa-miR-320a PPP3R1 -0.961144925954715 1.62478794429204e-08 -0.021451907795778 0.828812244123992 PITA;miRanda -0.0743860757945927 0.00492889680241471 NA NA NA hsa-miR-342-3p PPP3R1 -0.128691966564961 0.561034080130801 -0.021451907795778 0.828812244123992 MirTarget;miRanda;miRNATAP -0.120856614371424 2.53668736670026e-09 NA NA NA hsa-miR-34a-5p PPP3R1 1.40588612517769 8.60097477768592e-12 -0.021451907795778 0.828812244123992 miRNAWalker2_validate -0.170360603226023 4.36468130338985e-16 NA NA NA hsa-miR-501-3p PPP3R1 -0.0405952693028064 0.866802243505833 -0.021451907795778 0.828812244123992 miRNATAP -0.0803291258133932 1.74133795102059e-05 NA NA NA hsa-miR-532-3p PPP3R1 -0.677758187385834 0.0147557885796065 -0.021451907795778 0.828812244123992 miRNAWalker2_validate -0.062068732146897 0.000132551705698098 NA NA NA hsa-miR-708-3p PPP3R1 3.43841959417743 4.40027692981683e-28 -0.021451907795778 0.828812244123992 mirMAP -0.0541488455493096 0.000366553943356352 NA NA NA hsa-miR-590-3p PRKACA 0.83851360565783 0.00129224433453587 -0.443676224262766 8.90729530065689e-08 miRanda -0.0788396673277862 6.8467401141485e-06 NA NA NA hsa-let-7a-3p PRKACB 0.167285443861993 0.431834813181487 -0.337490057919314 0.0956151593593903 MirTarget;mirMAP;miRNATAP -0.109621340434496 0.0264314696722877 NA NA NA hsa-miR-141-3p PRKACB 3.36993755486106 5.42939251147195e-32 -0.337490057919314 0.0956151593593903 MirTarget;TargetScan;miRNATAP -0.127873218774198 2.27329955972899e-05 NA NA NA hsa-miR-146b-5p PRKACB 1.0922867893808 5.63754607494775e-06 -0.337490057919314 0.0956151593593903 miRanda -0.16173584971976 2.34820463010476e-05 NA NA NA hsa-miR-16-2-3p PRKACB 0.503964803530872 0.0263648405197492 -0.337490057919314 0.0956151593593903 mirMAP -0.126437256197819 0.00465216057285952 NA NA NA hsa-miR-17-5p PRKACB 2.07078488653279 2.77403038572568e-19 -0.337490057919314 0.0956151593593903 TargetScan -0.146235921583623 0.000160820334409303 NA NA NA hsa-miR-182-5p PRKACB 3.21839823004635 5.13049145201115e-39 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.112248448456467 0.00121734908239389 NA NA NA hsa-miR-183-5p PRKACB 2.39247234736657 3.92444525331999e-21 -0.337490057919314 0.0956151593593903 MirTarget -0.10185724563834 0.0037757174706069 NA NA NA hsa-miR-18a-5p PRKACB 1.37435209536521 9.2173853686829e-06 -0.337490057919314 0.0956151593593903 miRNATAP -0.0978562979830684 0.00245976063651106 NA NA NA hsa-miR-19a-3p PRKACB 2.11776595911517 7.07663078397156e-10 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.170735517959884 5.74076627300856e-08 NA NA NA hsa-miR-19b-3p PRKACB 2.10868505662119 5.40846613768389e-17 -0.337490057919314 0.0956151593593903 miRNAWalker2_validate;MirTarget;miRNATAP -0.197277470144974 1.27039043015725e-07 NA NA NA hsa-miR-200a-3p PRKACB 3.14766878548496 1.32850889777422e-21 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.0793517798602322 0.00413203940254079 NA NA NA hsa-miR-200b-3p PRKACB 1.55157578247391 4.83790020897188e-09 -0.337490057919314 0.0956151593593903 MirTarget;TargetScan -0.101454883897731 0.00336247964553013 NA NA NA hsa-miR-200c-3p PRKACB 0.380533388300368 0.0842181838538353 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.115374415768757 0.00655504187350906 NA NA NA hsa-miR-3065-5p PRKACB 0.653308707552535 0.0999497219778851 -0.337490057919314 0.0956151593593903 MirTarget -0.0726251804882558 0.00440370483860932 NA NA NA hsa-miR-339-5p PRKACB 0.536997313601114 0.0488090394176611 -0.337490057919314 0.0956151593593903 miRanda -0.172209477372762 3.7061891291678e-07 NA NA NA hsa-miR-34a-5p PRKACB 1.40588612517769 8.60097477768592e-12 -0.337490057919314 0.0956151593593903 miRNATAP -0.249544715069385 1.25392359331725e-08 NA NA NA hsa-miR-362-3p PRKACB 0.194097672030785 0.52808475179225 -0.337490057919314 0.0956151593593903 PITA;miRanda;miRNATAP -0.0984597973465023 0.00950839347569588 NA NA NA hsa-miR-362-5p PRKACB 0.658947634569393 0.0243306847205756 -0.337490057919314 0.0956151593593903 PITA -0.152310553896922 2.5944554975563e-06 NA NA NA hsa-miR-429 PRKACB 2.3794516574089 1.72813419703734e-13 -0.337490057919314 0.0956151593593903 MirTarget;PITA;miRanda;miRNATAP -0.120289214888389 7.31299726157361e-05 NA NA NA hsa-miR-450b-5p PRKACB 1.69248953402469 1.96052058003353e-07 -0.337490057919314 0.0956151593593903 mirMAP -0.0762989249899319 0.0159538149855252 NA NA NA hsa-miR-590-5p PRKACB 2.07441240363458 4.95240551694843e-14 -0.337490057919314 0.0956151593593903 miRanda -0.106057390676399 0.00956598336443456 NA NA NA hsa-miR-93-5p PRKACB 1.50844106515467 1.83836866996875e-12 -0.337490057919314 0.0956151593593903 miRNAWalker2_validate -0.173603248772151 4.27230598908178e-05 NA NA NA hsa-miR-96-5p PRKACB 3.0381097138467 4.40362891630201e-24 -0.337490057919314 0.0956151593593903 miRNATAP -0.19117539499709 1.28710220181067e-08 NA NA NA hsa-miR-10a-3p PRKAR1A 0.162369964979749 0.621747296513628 -0.476850604449272 2.68687886515723e-05 miRNATAP -0.071806167626016 0.000301246920234893 NA NA NA hsa-miR-1296-5p PRKAR1A -1.0770379559139 9.73200411034973e-05 -0.476850604449272 2.68687886515723e-05 miRNAWalker2_validate -0.0501220184728171 0.00804901158164186 NA NA NA hsa-miR-150-5p PRKAR1A -0.702328520623782 0.0215316651134431 -0.476850604449272 2.68687886515723e-05 miRNATAP -0.0608240003395642 0.000378910905449058 NA NA NA hsa-miR-155-5p PRKAR1A 0.813513839059142 0.000608282725633232 -0.476850604449272 2.68687886515723e-05 miRNAWalker2_validate -0.139999488103335 1.05258302094743e-10 NA NA NA hsa-miR-16-2-3p PRKAR1A 0.503964803530872 0.0263648405197492 -0.476850604449272 2.68687886515723e-05 mirMAP -0.0830396382488245 0.000950363463277555 NA NA NA hsa-miR-182-5p PRKAR1A 3.21839823004635 5.13049145201115e-39 -0.476850604449272 2.68687886515723e-05 miRNATAP -0.063658831727148 0.00112634791189307 NA NA NA hsa-miR-186-5p PRKAR1A 0.852175445703945 6.88885738584309e-10 -0.476850604449272 2.68687886515723e-05 mirMAP -0.187471435255471 5.73112383343186e-07 NA NA NA hsa-miR-25-3p PRKAR1A 0.361927330834176 0.0163670566170988 -0.476850604449272 2.68687886515723e-05 miRNAWalker2_validate -0.132918419142272 0.000149714233560858 NA NA NA hsa-miR-30c-5p PRKAR1A -0.327319105755825 0.123595832152687 -0.476850604449272 2.68687886515723e-05 mirMAP -0.110647555772676 7.09317835691076e-06 NA NA NA hsa-miR-30e-5p PRKAR1A 1.60414100786743 3.78951090573667e-19 -0.476850604449272 2.68687886515723e-05 mirMAP -0.102557156521551 0.000277416995755017 NA NA NA hsa-miR-320a PRKAR1A -0.961144925954715 1.62478794429204e-08 -0.476850604449272 2.68687886515723e-05 miRanda -0.0623593683268467 0.0421366888629896 NA NA NA hsa-miR-320b PRKAR1A 0.226640952564488 0.378818692487242 -0.476850604449272 2.68687886515723e-05 miRanda -0.0784255762276142 0.000117252645341386 NA NA NA hsa-miR-324-3p PRKAR1A -0.0774700133118458 0.689226297032231 -0.476850604449272 2.68687886515723e-05 miRNAWalker2_validate -0.063787353215563 0.019574225745743 NA NA NA hsa-miR-342-3p PRKAR1A -0.128691966564961 0.561034080130801 -0.476850604449272 2.68687886515723e-05 miRanda -0.195587101672966 2.00849194011625e-17 NA NA NA hsa-miR-429 PRKAR1A 2.3794516574089 1.72813419703734e-13 -0.476850604449272 2.68687886515723e-05 PITA;miRanda;miRNATAP -0.0596236322000476 0.000495960986520138 NA NA NA hsa-miR-590-3p PRKAR1A 0.83851360565783 0.00129224433453587 -0.476850604449272 2.68687886515723e-05 miRanda;mirMAP -0.137053164571483 8.41662596940527e-09 NA NA NA hsa-miR-590-5p PRKAR1A 2.07441240363458 4.95240551694843e-14 -0.476850604449272 2.68687886515723e-05 miRanda -0.195670821518842 1.25064405614133e-18 NA NA NA hsa-miR-96-5p PRKAR1A 3.0381097138467 4.40362891630201e-24 -0.476850604449272 2.68687886515723e-05 miRNAWalker2_validate;TargetScan;miRNATAP -0.128985822937838 6.61017716853541e-12 NA NA NA hsa-let-7a-3p PRKAR2A 0.167285443861993 0.431834813181487 -0.542111912815549 0.00820991566022701 mirMAP -0.129600545591328 0.00965385633423682 NA NA NA hsa-miR-103a-3p PRKAR2A 0.538497806383155 1.88134691850591e-05 -0.542111912815549 0.00820991566022701 miRNAWalker2_validate -0.182915804223543 0.0161204820560304 NA NA NA hsa-miR-106a-5p PRKAR2A 1.3902608059488 6.07931522284525e-05 -0.542111912815549 0.00820991566022701 mirMAP -0.182529692623676 9.11118517871937e-10 NA NA NA hsa-miR-106b-5p PRKAR2A 1.47447672652218 1.32004094930462e-13 -0.542111912815549 0.00820991566022701 mirMAP -0.130098878664838 0.00508433606379257 NA NA NA hsa-miR-10a-3p PRKAR2A 0.162369964979749 0.621747296513628 -0.542111912815549 0.00820991566022701 mirMAP -0.147560768203991 3.61634378140385e-05 NA NA NA hsa-miR-125a-5p PRKAR2A -1.04824536696301 3.97386082850476e-07 -0.542111912815549 0.00820991566022701 miRanda -0.119074803105274 0.00875043226956617 NA NA NA hsa-miR-142-5p PRKAR2A 1.29672439149353 4.0768822158894e-06 -0.542111912815549 0.00820991566022701 mirMAP -0.121135593752335 0.00078655285231452 NA NA NA hsa-miR-148a-3p PRKAR2A 2.30885799126944 1.95226081368985e-21 -0.542111912815549 0.00820991566022701 mirMAP -0.10473104721013 0.00495918694210131 NA NA NA hsa-miR-155-5p PRKAR2A 0.813513839059142 0.000608282725633232 -0.542111912815549 0.00820991566022701 miRNAWalker2_validate -0.146428684740871 0.000220862251552694 NA NA NA hsa-miR-16-5p PRKAR2A 0.749619098384047 4.11649450706988e-06 -0.542111912815549 0.00820991566022701 miRNAWalker2_validate -0.16233712492249 0.0052000527267614 NA NA NA hsa-miR-17-5p PRKAR2A 2.07078488653279 2.77403038572568e-19 -0.542111912815549 0.00820991566022701 mirMAP -0.158416749162573 5.53315845810464e-05 NA NA NA hsa-miR-20a-5p PRKAR2A 2.64649625616975 5.1469418982085e-27 -0.542111912815549 0.00820991566022701 mirMAP -0.177689732696527 8.05056914879578e-07 NA NA NA hsa-miR-20b-5p PRKAR2A 1.35770573270947 0.00260808530013016 -0.542111912815549 0.00820991566022701 mirMAP -0.0951350977699404 1.38200024912605e-05 NA NA NA hsa-miR-21-5p PRKAR2A 4.38165933891779 1.52536633902505e-92 -0.542111912815549 0.00820991566022701 mirMAP -0.150363567953701 2.70425744412111e-05 NA NA NA hsa-miR-26b-5p PRKAR2A 0.72362441215247 4.7794659748036e-05 -0.542111912815549 0.00820991566022701 mirMAP -0.254835302085191 1.33543677793609e-06 NA NA NA hsa-miR-29a-5p PRKAR2A 1.89519956688438 1.03453349363915e-11 -0.542111912815549 0.00820991566022701 mirMAP -0.144340188354051 0.000269848610546557 NA NA NA hsa-miR-32-5p PRKAR2A 0.876853679269853 6.04859399018691e-05 -0.542111912815549 0.00820991566022701 mirMAP -0.149276001882109 0.00141193110732772 NA NA NA hsa-miR-320b PRKAR2A 0.226640952564488 0.378818692487242 -0.542111912815549 0.00820991566022701 mirMAP -0.0730843853812625 0.047648110028895 NA NA NA hsa-miR-342-5p PRKAR2A -0.382174669348421 0.0896996965047193 -0.542111912815549 0.00820991566022701 miRNATAP -0.0959510862547627 0.0229551938274865 NA NA NA hsa-miR-363-3p PRKAR2A -0.301366430789287 0.414451883803084 -0.542111912815549 0.00820991566022701 mirMAP -0.0931571191757036 0.000277264216669843 NA NA NA hsa-miR-582-5p PRKAR2A 1.08286181406653 0.00149040450161757 -0.542111912815549 0.00820991566022701 miRNATAP -0.106418125415066 0.000164630904331123 NA NA NA hsa-miR-590-5p PRKAR2A 2.07441240363458 4.95240551694843e-14 -0.542111912815549 0.00820991566022701 mirMAP -0.169616630819392 4.04701086495302e-05 NA NA NA hsa-miR-708-3p PRKAR2A 3.43841959417743 4.40027692981683e-28 -0.542111912815549 0.00820991566022701 mirMAP -0.130264413500301 3.805520704434e-05 NA NA NA hsa-miR-766-3p PRKAR2A 0.0784037775118556 0.760091599198293 -0.542111912815549 0.00820991566022701 mirMAP -0.0776174343309443 0.0360136137493123 NA NA NA hsa-miR-186-5p PRKAR2B 0.852175445703945 6.88885738584309e-10 -0.603510949504182 0.0393539020155484 mirMAP -0.203735577280849 0.0366327794799357 NA NA NA hsa-miR-361-5p PRKAR2B 0.21454431962475 0.0800957579368424 -0.603510949504182 0.0393539020155484 miRanda -0.33231834049798 0.00308352468710608 NA NA NA hsa-miR-9-5p PRKAR2B 4.99250901331516 2.59132733422801e-19 -0.603510949504182 0.0393539020155484 miRNATAP -0.0776771110696683 0.000822844384295863 NA NA NA hsa-miR-92a-3p PRKAR2B -0.136362762339122 0.493412263619364 -0.603510949504182 0.0393539020155484 miRNATAP -0.152470358659526 0.0256836387516207 NA NA NA hsa-miR-182-5p PRKX 3.21839823004635 5.13049145201115e-39 -0.138434262119447 0.395012462656297 mirMAP -0.0547588753987889 0.049937393723501 NA NA NA hsa-miR-224-5p PRKX 1.9183903633152 3.22216766330296e-06 -0.138434262119447 0.395012462656297 mirMAP -0.056838055729776 0.0015040369356702 NA NA NA hsa-miR-33a-5p PRKX 2.80127809675219 5.09053890529424e-12 -0.138434262119447 0.395012462656297 mirMAP -0.0581977611720156 0.00906645562084667 NA NA NA hsa-miR-450b-5p PRKX 1.69248953402469 1.96052058003353e-07 -0.138434262119447 0.395012462656297 mirMAP -0.119346741491602 2.11739235739311e-06 NA NA NA hsa-miR-542-3p PRKX 1.62226640768239 2.6427102465476e-10 -0.138434262119447 0.395012462656297 mirMAP -0.149271020180693 1.30948834311169e-07 NA NA NA hsa-miR-590-3p PRKX 0.83851360565783 0.00129224433453587 -0.138434262119447 0.395012462656297 mirMAP -0.0723725727433128 0.0354026937281372 NA NA NA hsa-miR-96-5p PRKX 3.0381097138467 4.40362891630201e-24 -0.138434262119447 0.395012462656297 mirMAP -0.0589401903482743 0.0312197297064641 NA NA NA hsa-miR-101-5p RELA -0.0265235292039296 0.917878791358577 -0.081895641025838 0.294391983957788 mirMAP -0.0552185452300698 0.00136892099465747 NA NA NA hsa-miR-30e-5p RELA 1.60414100786743 3.78951090573667e-19 -0.081895641025838 0.294391983957788 miRNAWalker2_validate -0.0658100532824802 0.000581468071376979 NA NA NA hsa-miR-107 TNF 0.658676029898313 5.11480446318819e-07 -0.830982767486341 0.0138827131679617 miRanda -0.439603202171767 0.000221374639268502 NA NA NA hsa-miR-203a-3p TNF 1.06866854356847 0.00389979689199624 -0.830982767486341 0.0138827131679617 miRTarBase -0.103500315237721 0.0136268268780759 NA NA NA hsa-miR-320b TNF 0.226640952564488 0.378818692487242 -0.830982767486341 0.0138827131679617 miRanda -0.148152717399537 0.0147197238778624 NA NA NA hsa-miR-429 TNF 2.3794516574089 1.72813419703734e-13 -0.830982767486341 0.0138827131679617 miRNATAP -0.135544464882007 0.00782170177882693 NA NA NA hsa-miR-145-5p TNFRSF10A -1.34926078156437 2.63526538800669e-07 0.313937445636065 0.126469321676362 MirTarget -0.0889903231568719 0.0126411918642092 NA NA NA hsa-miR-362-3p TNFRSF10A 0.194097672030785 0.52808475179225 0.313937445636065 0.126469321676362 miRanda -0.171482203608969 7.28861591280272e-06 NA NA NA hsa-miR-340-5p TNFRSF10B -0.668005790839634 0.018612920432186 0.178447201136893 0.311593856462823 miRNAWalker2_validate -0.0652363866933771 0.0483722633600547 NA NA NA hsa-miR-542-3p TNFRSF10B 1.62226640768239 2.6427102465476e-10 0.178447201136893 0.311593856462823 miRanda -0.0687998158596235 0.0266605623014381 NA NA NA hsa-miR-590-5p TNFRSF10B 2.07441240363458 4.95240551694843e-14 0.178447201136893 0.311593856462823 miRanda -0.0938540418403939 0.00835552261219354 NA NA NA hsa-miR-940 TNFRSF10B 0.011138136211269 0.974925352379525 0.178447201136893 0.311593856462823 miRNAWalker2_validate -0.141318772516878 2.62411186947218e-08 NA NA NA hsa-miR-193a-3p TNFRSF10C 0.549173467360291 0.0319030569365466 -0.154947494831521 0.59571603471051 miRanda -0.290120931664436 2.74949804872591e-07 NA NA NA hsa-miR-361-5p TNFRSF10C 0.21454431962475 0.0800957579368424 -0.154947494831521 0.59571603471051 miRanda -0.237444664053092 0.0339776756633854 NA NA NA hsa-miR-362-3p TNFRSF10D 0.194097672030785 0.52808475179225 -1.03846175939343 8.86767948326941e-06 miRanda -0.100403304163926 0.0233388202604092 NA NA NA hsa-miR-590-3p TNFRSF10D 0.83851360565783 0.00129224433453587 -1.03846175939343 8.86767948326941e-06 miRanda -0.116986382261948 0.0191591361661586 NA NA NA hsa-miR-590-5p TNFRSF10D 2.07441240363458 4.95240551694843e-14 -1.03846175939343 8.86767948326941e-06 miRanda -0.154057594157847 0.00120741838184007 NA NA NA hsa-miR-7-1-3p TNFRSF10D 2.61364240402652 1.98959237815786e-32 -1.03846175939343 8.86767948326941e-06 mirMAP -0.136420129073792 0.00490554426295682 NA NA NA hsa-miR-342-3p TNFRSF1A -0.128691966564961 0.561034080130801 -0.145342911551223 0.293679112583126 miRanda -0.0593208120492042 0.0399828051735453 NA NA NA hsa-miR-129-5p TNFSF10 -0.405735314747643 0.341485636033577 -0.677117519988638 0.00834629178259813 miRanda -0.0945989084500559 0.000681287232280908 NA NA NA hsa-miR-217 TNFSF10 1.88358668330143 3.93795605235061e-07 -0.677117519988638 0.00834629178259813 miRanda -0.0675250564709578 0.0484702461625958 NA NA NA hsa-miR-221-3p TP53 -0.0986794612964683 0.654454148658401 0.279200516102425 0.154180310374282 miRNAWalker2_validate -0.0867389752351238 0.0350345596481609 20880178;24324033 Circulating miR 221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression; The correlation between miR-221 levels and protein levels of p53 CEA ER and PR clinicopathological features or overall survival was analyzed; The immunohistochemistry analysis demonstrates a significant correlation between plasma miR-221 level and p53 expression; The direct amplification of plasma miR-221 can be used as a potential noninvasive molecular marker for diagnosis and prognosis of CRC and is correlated with p53 expression;Interestingly miR-221 can activate the p53/mdm2 axis by inhibiting MDM2 and in turn p53 activation contributes to miR-221 enhanced expression; Moreover by modulating the p53 axis miR-221 impacts cell-cycle progression and apoptotic response to doxorubicin in hepatocellular carcinoma-derived cell lines; These data were confirmed in clinical specimens of hepatocellular carcinoma in which elevated miR-221 expression was associated with the simultaneous presence of wild-type p53 and DNA hypomethylation poor survival;worse prognosis;progression;drug resistance colorectal cancer;liver cancer hsa-miR-222-3p TP53 0.0327210697409583 0.881937768109611 0.279200516102425 0.154180310374282 miRNAWalker2_validate -0.0870747150503206 0.034471732082465 NA NA NA hsa-miR-421 TP53 0.170525317701774 0.535277026680289 0.279200516102425 0.154180310374282 miRanda -0.0778993398579053 0.029287340276253 NA NA NA hsa-miR-125a-3p TRADD -1.04954492275266 2.45974219476832e-06 0.530329936763994 0.000508179124650094 miRanda -0.077448650407039 0.0137553718002076 NA NA NA hsa-miR-324-3p TRADD -0.0774700133118458 0.689226297032231 0.530329936763994 0.000508179124650094 miRNATAP -0.0925200261289915 0.011608161636838 NA NA NA hsa-miR-140-3p TRAF2 -1.11373309124537 8.35257079443689e-14 1.00807946070122 6.3314135046518e-09 MirTarget -0.244688143587184 4.1120893831993e-06 NA NA NA hsa-miR-106a-5p XIAP 1.3902608059488 6.07931522284525e-05 0.311178443599883 0.00189888955771199 miRNAWalker2_validate -0.0617684351154955 2.52121115464966e-05 NA NA NA hsa-miR-125b-5p XIAP -0.548859243919575 0.0107224406584463 0.311178443599883 0.00189888955771199 miRNAWalker2_validate -0.0612737674892351 0.00426821074575412 NA NA NA hsa-miR-140-3p XIAP -1.11373309124537 8.35257079443689e-14 0.311178443599883 0.00189888955771199 mirMAP -0.134806533023976 7.86246400028474e-06 NA NA NA hsa-miR-142-5p XIAP 1.29672439149353 4.0768822158894e-06 0.311178443599883 0.00189888955771199 mirMAP;miRNATAP -0.055037345083499 0.0017410815091149 NA NA NA hsa-miR-155-5p XIAP 0.813513839059142 0.000608282725633232 0.311178443599883 0.00189888955771199 MirTarget -0.081367202050653 2.3788493470019e-05 26779627 Bioinformatic predictions the dual-luciferase reporter assay and western blot analysis were used to detect how miR-155 regulates X-linked inhibitor of apoptosis protein XIAP; Furthermore the results from the luciferase assays and western blot analysis identified XIAP as the direct target of miR-155; In addition introducing XIAP cDNA without a three prime untranslated region 3'-UTR rescued the miR-155 promotion of apoptosis; These results indicate that miR-155 mediates cisplatin-induced apoptosis by targeting XIAP in ovarian cancer cells and that miR-155 could be a potential therapeutic target to increase the efficiency of ovarian cancer interventions ovarian cancer hsa-miR-16-1-3p XIAP 1.50034693398929 6.63958242991125e-10 0.311178443599883 0.00189888955771199 mirMAP -0.0841590347267613 0.000271552200762998 NA NA NA hsa-miR-16-2-3p XIAP 0.503964803530872 0.0263648405197492 0.311178443599883 0.00189888955771199 mirMAP -0.0893882526510146 4.74401760549479e-05 NA NA NA hsa-miR-17-5p XIAP 2.07078488653279 2.77403038572568e-19 0.311178443599883 0.00189888955771199 miRNAWalker2_validate;TargetScan -0.104621962395686 3.56642452518644e-08 NA NA NA hsa-miR-186-5p XIAP 0.852175445703945 6.88885738584309e-10 0.311178443599883 0.00189888955771199 MirTarget;miRNATAP -0.106770220904771 0.00127610812666367 NA NA NA hsa-miR-19a-3p XIAP 2.11776595911517 7.07663078397156e-10 0.311178443599883 0.00189888955771199 mirMAP -0.0836512051973818 7.47177980884852e-08 NA NA NA hsa-miR-19b-1-5p XIAP 1.71217036351784 3.28561659177495e-12 0.311178443599883 0.00189888955771199 MirTarget -0.0685050677094343 0.00120374273298048 NA NA NA hsa-miR-19b-3p XIAP 2.10868505662119 5.40846613768389e-17 0.311178443599883 0.00189888955771199 mirMAP -0.0517430605874044 0.00553174669930476 NA NA NA hsa-miR-20a-5p XIAP 2.64649625616975 5.1469418982085e-27 0.311178443599883 0.00189888955771199 miRNATAP -0.0820376870791662 2.96264654575147e-06 NA NA NA hsa-miR-25-3p XIAP 0.361927330834176 0.0163670566170988 0.311178443599883 0.00189888955771199 mirMAP -0.105648114201262 0.000601509319956213 NA NA NA hsa-miR-26a-2-3p XIAP 0.264287787772609 0.305653616292982 0.311178443599883 0.00189888955771199 mirMAP -0.0682337932219392 0.00222551477253611 NA NA NA hsa-miR-363-3p XIAP -0.301366430789287 0.414451883803084 0.311178443599883 0.00189888955771199 mirMAP -0.051206388148913 3.89932241656526e-05 NA NA NA hsa-miR-484 XIAP -0.228576985124486 0.244112867390855 0.311178443599883 0.00189888955771199 mirMAP -0.110023475185489 2.657115273949e-06 NA NA NA hsa-miR-500a-5p XIAP 0.648155655714409 0.0104657432932038 0.311178443599883 0.00189888955771199 mirMAP;miRNATAP -0.0641597916467824 0.000577085173029761 NA NA NA hsa-miR-532-5p XIAP 0.576620898517708 0.0023245812680956 0.311178443599883 0.00189888955771199 mirMAP -0.0629421345335562 0.00988163159356307 NA NA NA hsa-miR-589-3p XIAP 1.34253876396688 1.84935927493927e-05 0.311178443599883 0.00189888955771199 MirTarget -0.0583527392747821 9.84851409152191e-05 NA NA NA hsa-miR-590-3p XIAP 0.83851360565783 0.00129224433453587 0.311178443599883 0.00189888955771199 MirTarget;miRanda;mirMAP -0.062592536209782 0.00307373053054558 NA NA NA hsa-miR-766-3p XIAP 0.0784037775118556 0.760091599198293 0.311178443599883 0.00189888955771199 mirMAP -0.0787320862167532 1.06163420089885e-05 NA NA NA hsa-miR-92a-3p XIAP -0.136362762339122 0.493412263619364 0.311178443599883 0.00189888955771199 mirMAP -0.115780408737922 5.14759041621164e-07 NA NA NA