miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-107 ACVR1 1.30977326593435 1.30372468603965e-11 -0.440784615093559 0.011428168867015 miRanda -0.31975275236104 1.72457785357338e-14 NA NA NA hsa-miR-130a-3p ACVR1 2.02021855058359 1.26427102520415e-11 -0.440784615093559 0.011428168867015 miRNAWalker2_validate;MirTarget;miRNATAP -0.105634597163712 0.000122877622339379 NA NA NA hsa-miR-130b-3p ACVR1 3.5350292994509 1.73934183852569e-27 -0.440784615093559 0.011428168867015 miRNAWalker2_validate;MirTarget;miRNATAP -0.203408449182766 2.74884028596702e-18 NA NA NA hsa-miR-148a-3p ACVR1 1.26728238710376 2.52325607402829e-06 -0.440784615093559 0.011428168867015 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.110862668181035 0.000345005837807225 NA NA NA hsa-miR-148b-3p ACVR1 1.97815018171325 6.07715327281595e-26 -0.440784615093559 0.011428168867015 MirTarget -0.378104594701851 1.72232598270337e-20 NA NA NA hsa-miR-16-2-3p ACVR1 2.31623086727196 4.29838149388188e-20 -0.440784615093559 0.011428168867015 mirMAP -0.204317547257783 7.39511178542122e-11 NA NA NA hsa-miR-182-5p ACVR1 3.53923166221814 5.07781258121574e-21 -0.440784615093559 0.011428168867015 MirTarget;miRNATAP -0.149490341775743 6.26318281352499e-13 NA NA NA hsa-miR-186-5p ACVR1 1.47445398888668 3.0781726595413e-15 -0.440784615093559 0.011428168867015 miRNAWalker2_validate -0.370599858746242 2.13887000918297e-18 NA NA NA hsa-miR-197-3p ACVR1 1.75733174019505 8.88576793100499e-13 -0.440784615093559 0.011428168867015 miRNAWalker2_validate -0.26211209446772 5.9021399873813e-16 NA NA NA hsa-miR-19b-3p ACVR1 2.49529833021187 1.57028265846699e-23 -0.440784615093559 0.011428168867015 miRNAWalker2_validate -0.274242303495673 4.97122224748929e-19 NA NA NA hsa-miR-301a-3p ACVR1 2.81024345929638 2.29784847962242e-17 -0.440784615093559 0.011428168867015 MirTarget;miRNATAP -0.205543720326161 1.85946342235684e-16 NA NA NA hsa-miR-30b-5p ACVR1 0.800822374912712 0.000133601914525413 -0.440784615093559 0.011428168867015 MirTarget -0.329574793102883 2.03444639344972e-17 NA NA NA hsa-miR-30c-5p ACVR1 0.778774633108 0.000285599212429136 -0.440784615093559 0.011428168867015 MirTarget;miRNATAP -0.326200824165502 7.06923031946761e-18 NA NA NA hsa-miR-30d-5p ACVR1 0.675423997639582 0.00270618816039773 -0.440784615093559 0.011428168867015 MirTarget;miRNATAP -0.285513477371053 4.44714078861004e-15 NA NA NA hsa-miR-30e-5p ACVR1 1.23904909539663 1.35561917122157e-09 -0.440784615093559 0.011428168867015 MirTarget -0.41124141628152 8.10407897701466e-27 NA NA NA hsa-miR-320a ACVR1 0.438165828017084 0.0390159073347133 -0.440784615093559 0.011428168867015 miRanda -0.166985099353045 2.71857168325616e-05 NA NA NA hsa-miR-320b ACVR1 1.55692969039548 1.41071034251915e-08 -0.440784615093559 0.011428168867015 miRanda -0.166934056746311 2.30215138951439e-08 NA NA NA hsa-miR-330-3p ACVR1 0.876747334239085 0.00073709016089703 -0.440784615093559 0.011428168867015 MirTarget;PITA -0.174770129448115 4.78980257564604e-08 NA NA NA hsa-miR-335-5p ACVR1 1.77247705492746 2.22457658872091e-06 -0.440784615093559 0.011428168867015 miRNAWalker2_validate -0.137669043256431 2.85648205743135e-10 NA NA NA hsa-miR-362-3p ACVR1 2.0756816987665 3.89026064579331e-12 -0.440784615093559 0.011428168867015 miRanda -0.196962040927184 1.24412801779332e-12 NA NA NA hsa-miR-429 ACVR1 4.48815175680773 2.44117492218206e-17 -0.440784615093559 0.011428168867015 miRNATAP -0.129138312530994 1.16091688444229e-18 NA NA NA hsa-miR-454-3p ACVR1 2.47234127820054 1.12878018736016e-21 -0.440784615093559 0.011428168867015 MirTarget;miRNATAP -0.252558225063471 2.9177658627946e-16 NA NA NA hsa-miR-491-5p ACVR1 0.615770352820862 0.0418295628761654 -0.440784615093559 0.011428168867015 PITA;miRanda -0.129233604165901 1.37955062495935e-05 NA NA NA hsa-miR-590-3p ACVR1 2.59289455139753 1.03200520972022e-21 -0.440784615093559 0.011428168867015 miRanda -0.204476248314497 6.74294806026135e-12 NA NA NA hsa-miR-96-5p ACVR1 4.89433085814374 1.92000659886961e-31 -0.440784615093559 0.011428168867015 TargetScan;miRNATAP -0.146980491476358 1.94717488369091e-15 NA NA NA hsa-miR-181c-5p ACVR1C 1.58587920618301 1.57506918816933e-10 0.21453923504713 0.688241332944138 miRNATAP -0.410111937086073 5.75688864447839e-05 NA NA NA hsa-let-7i-5p ACVR2A 0.412877696970403 0.00622731051981756 -0.441125848560914 0.026460556202827 miRNATAP -0.402921626224127 2.55622635882579e-10 NA NA NA hsa-miR-125b-5p ACVR2A -1.16462950151259 0.000288900271798384 -0.441125848560914 0.026460556202827 miRNATAP -0.137089493272504 3.46840453610637e-06 NA NA NA hsa-miR-130a-3p ACVR2A 2.02021855058359 1.26427102520415e-11 -0.441125848560914 0.026460556202827 miRNATAP -0.159630183774161 2.99476963163926e-07 NA NA NA hsa-miR-142-3p ACVR2A 2.75247908790621 1.45636065474764e-12 -0.441125848560914 0.026460556202827 MirTarget;PITA;miRanda;miRNATAP -0.204583720066055 7.33000461023718e-19 NA NA NA hsa-miR-142-5p ACVR2A 1.17581605694506 0.0018174701991234 -0.441125848560914 0.026460556202827 PITA;mirMAP -0.220202248652775 1.33270632567427e-19 NA NA NA hsa-miR-155-5p ACVR2A 1.20164021433135 0.00086170622431261 -0.441125848560914 0.026460556202827 miRNATAP -0.255918091207365 1.98454371097519e-24 NA NA NA hsa-miR-181a-5p ACVR2A 2.29556023480783 1.8138457900616e-21 -0.441125848560914 0.026460556202827 MirTarget;miRNATAP -0.105055977935461 0.00580229044675701 NA NA NA hsa-miR-193b-5p ACVR2A 1.59567208918739 4.89398272459427e-08 -0.441125848560914 0.026460556202827 MirTarget -0.142460160622611 9.70680019444201e-06 NA NA NA hsa-miR-199a-3p ACVR2A 0.640600337515787 0.0380326905134914 -0.441125848560914 0.026460556202827 MirTarget;PITA;miRNATAP -0.215539638097745 1.32196572960459e-12 NA NA NA hsa-miR-199a-5p ACVR2A 0.592984035153911 0.0674836634175293 -0.441125848560914 0.026460556202827 PITA;miRanda;miRNATAP -0.100835445137614 0.000658080314154466 NA NA NA hsa-miR-199b-3p ACVR2A 0.643923492750702 0.0371742251925406 -0.441125848560914 0.026460556202827 MirTarget;PITA;miRNATAP -0.215312810621173 1.34673407763154e-12 NA NA NA hsa-miR-21-5p ACVR2A 2.73773305747971 1.38864982139576e-43 -0.441125848560914 0.026460556202827 miRNATAP -0.284055521612916 4.65355642719279e-11 NA NA NA hsa-miR-223-3p ACVR2A 0.390350910791999 0.345956164976892 -0.441125848560914 0.026460556202827 MirTarget -0.185177401490054 1.40413976596905e-16 NA NA NA hsa-miR-27a-3p ACVR2A 1.66542180327138 4.93775737894805e-13 -0.441125848560914 0.026460556202827 miRNATAP -0.277764123702842 3.07742159183552e-12 NA NA NA hsa-miR-29a-3p ACVR2A -0.35074463683376 0.161238718982428 -0.441125848560914 0.026460556202827 miRNATAP -0.297870946809463 1.58145115247523e-15 NA NA NA hsa-miR-29a-5p ACVR2A 1.46749674755271 3.34605004270294e-07 -0.441125848560914 0.026460556202827 mirMAP;miRNATAP -0.283852337483164 3.79235156617688e-17 NA NA NA hsa-miR-30a-5p ACVR2A -0.878357906436456 0.000509952992366057 -0.441125848560914 0.026460556202827 miRNATAP -0.113691340352321 0.00276398142975327 NA NA NA hsa-miR-338-5p ACVR2A -0.577691606146419 0.0472212680542825 -0.441125848560914 0.026460556202827 PITA;mirMAP;miRNATAP -0.178422022236987 6.14293784463176e-08 NA NA NA hsa-miR-424-5p ACVR2A 1.61930224569578 1.89642549274994e-10 -0.441125848560914 0.026460556202827 MirTarget;miRNATAP -0.179988275962292 1.00805934071111e-06 NA NA NA hsa-miR-493-5p ACVR2A 0.847772103665986 0.00528678068747754 -0.441125848560914 0.026460556202827 miRNATAP -0.122408459222405 0.000105986328714938 NA NA NA hsa-miR-589-3p ACVR2A 2.51971841868825 2.39125940264107e-11 -0.441125848560914 0.026460556202827 mirMAP -0.104883249085319 0.000203964340756497 NA NA NA hsa-let-7b-3p ACVR2B 0.868207752019623 1.30460056774366e-05 0.832994991825976 0.000581308387561646 MirTarget -0.166726883923475 0.00481302718838053 NA NA NA hsa-miR-142-5p ACVR2B 1.17581605694506 0.0018174701991234 0.832994991825976 0.000581308387561646 PITA -0.148697160230852 1.37180673014926e-06 NA NA NA hsa-miR-199a-3p ACVR2B 0.640600337515787 0.0380326905134914 0.832994991825976 0.000581308387561646 PITA;miRNATAP -0.159979451944044 2.45227302611455e-05 NA NA NA hsa-miR-199a-5p ACVR2B 0.592984035153911 0.0674836634175293 0.832994991825976 0.000581308387561646 PITA;miRNATAP -0.112642929602254 0.00190236139733677 NA NA NA hsa-miR-199b-3p ACVR2B 0.643923492750702 0.0371742251925406 0.832994991825976 0.000581308387561646 PITA;miRNATAP -0.159499830911431 2.56176360260945e-05 NA NA NA hsa-miR-199b-5p ACVR2B 0.218704279044827 0.519493319158441 0.832994991825976 0.000581308387561646 PITA -0.100126795431124 0.00392887346368321 NA NA NA hsa-miR-106a-5p BMP2 2.48882002962836 1.99757727374521e-12 -1.4585556992146 0.00276269620457527 miRNATAP -0.13733219575815 0.0353378641266495 NA NA NA hsa-miR-17-5p BMP2 3.2710598467455 9.93128340539455e-27 -1.4585556992146 0.00276269620457527 TargetScan -0.179082884567471 0.0139285781243937 NA NA NA hsa-miR-20a-5p BMP2 3.15577933619191 4.19753346442454e-25 -1.4585556992146 0.00276269620457527 miRNATAP -0.172086381139174 0.0189386691781264 NA NA NA hsa-miR-3065-5p BMP2 2.74629919868982 1.86846589298284e-08 -1.4585556992146 0.00276269620457527 mirMAP -0.271238334102083 2.81263836360285e-06 NA NA NA hsa-miR-335-3p BMP2 3.08791651139852 5.31309869723517e-12 -1.4585556992146 0.00276269620457527 mirMAP -0.11624777686982 0.0240386766712432 NA NA NA hsa-miR-142-3p BMP4 2.75247908790621 1.45636065474764e-12 -1.57065098962083 0.000133932493512791 PITA;miRanda -0.139369719608241 0.00541531782039283 NA NA NA hsa-miR-590-3p BMP4 2.59289455139753 1.03200520972022e-21 -1.57065098962083 0.000133932493512791 miRanda -0.366398585543619 3.213147138986e-07 NA NA NA hsa-miR-340-5p BMP5 0.30282999308409 0.157744789519131 -4.52631327010929 8.652621809138e-11 mirMAP -0.367739218991074 0.0239861645438102 NA NA NA hsa-miR-450b-5p BMP5 1.69244418548325 1.68064054148881e-10 -4.52631327010929 8.652621809138e-11 mirMAP -0.259274584528462 0.043338832754594 NA NA NA hsa-miR-576-5p BMP5 2.20467023993664 3.4053475193793e-19 -4.52631327010929 8.652621809138e-11 mirMAP -0.455108363311804 0.000719254735006134 NA NA NA hsa-miR-590-3p BMP5 2.59289455139753 1.03200520972022e-21 -4.52631327010929 8.652621809138e-11 mirMAP -0.378335992480482 0.00244428676533185 NA NA NA hsa-miR-944 BMP5 2.91186649218281 1.31574753528144e-06 -4.52631327010929 8.652621809138e-11 mirMAP -0.148090085633931 0.0113662958843778 NA NA NA hsa-miR-130b-3p BMP6 3.5350292994509 1.73934183852569e-27 -0.50213082357528 0.129852040956245 MirTarget -0.160881805826862 0.0004745109488921 NA NA NA hsa-miR-301a-3p BMP6 2.81024345929638 2.29784847962242e-17 -0.50213082357528 0.129852040956245 MirTarget -0.218492005642097 7.6576704866361e-06 NA NA NA hsa-miR-320a BMP6 0.438165828017084 0.0390159073347133 -0.50213082357528 0.129852040956245 PITA;miRanda -0.247741579467164 0.00111437088429099 NA NA NA hsa-miR-320b BMP6 1.55692969039548 1.41071034251915e-08 -0.50213082357528 0.129852040956245 PITA;miRanda -0.232557979098243 4.95120956708228e-05 NA NA NA hsa-miR-34c-5p BMP6 2.07190852984647 7.35776320806257e-08 -0.50213082357528 0.129852040956245 miRanda -0.11847860283684 0.00681491870697078 NA NA NA hsa-miR-454-3p BMP6 2.47234127820054 1.12878018736016e-21 -0.50213082357528 0.129852040956245 MirTarget -0.179262375804332 0.00317917125472434 NA NA NA hsa-miR-590-3p BMP6 2.59289455139753 1.03200520972022e-21 -0.50213082357528 0.129852040956245 mirMAP -0.18948662565478 0.00106147689407981 NA NA NA hsa-miR-590-5p BMP6 3.18300989862077 2.06813568597893e-26 -0.50213082357528 0.129852040956245 miRanda -0.185298256321475 0.000329323108000979 NA NA NA hsa-miR-106a-5p BMP7 2.48882002962836 1.99757727374521e-12 -1.77720755920917 0.028758021459053 mirMAP -0.213107626919806 0.0497769925486375 NA NA NA hsa-miR-17-5p BMP7 3.2710598467455 9.93128340539455e-27 -1.77720755920917 0.028758021459053 mirMAP -0.30309517063183 0.0123654622246275 NA NA NA hsa-miR-20b-5p BMP7 2.07706563022469 1.10107236083433e-05 -1.77720755920917 0.028758021459053 mirMAP -0.167918446086084 0.0420527528441079 NA NA NA hsa-miR-338-3p BMP7 0.453166438193782 0.144583389707558 -1.77720755920917 0.028758021459053 miRanda -0.411479827858547 0.00118108686362591 NA NA NA hsa-miR-342-3p BMP7 1.49115144672245 1.43879249744621e-07 -1.77720755920917 0.028758021459053 miRNAWalker2_validate;miRTarBase;miRanda -0.564549946965806 3.57247612956533e-05 NA NA NA hsa-miR-362-3p BMP7 2.0756816987665 3.89026064579331e-12 -1.77720755920917 0.028758021459053 miRanda -0.30784906106111 0.0207029789815096 NA NA NA hsa-miR-450b-5p BMP7 1.69244418548325 1.68064054148881e-10 -1.77720755920917 0.028758021459053 mirMAP -0.312735833754277 0.0324802930889376 NA NA NA hsa-miR-30b-3p BMP8A 0.834142820354026 0.000972582820878813 1.41736177621035 1.68060292641289e-08 MirTarget -0.181506102948814 0.000207303144028512 NA NA NA hsa-miR-30d-3p BMP8A 0.977747550180601 4.3048212205381e-05 1.41736177621035 1.68060292641289e-08 MirTarget -0.209644722182892 4.46988132772963e-05 NA NA NA hsa-miR-30e-3p BMP8A -0.215663037684509 0.235375122783546 1.41736177621035 1.68060292641289e-08 MirTarget -0.330734323380831 1.3029240477641e-06 NA NA NA hsa-miR-423-5p BMP8A 0.963563145758616 9.86109015204915e-07 1.41736177621035 1.68060292641289e-08 MirTarget -0.28768488873678 3.67538714707699e-06 NA NA NA hsa-let-7a-5p BMPR1A 0.618599506841644 2.76973453058748e-05 -0.769696479269679 2.04474538839979e-07 TargetScan -0.102879726818816 0.0393037672375543 NA NA NA hsa-miR-140-5p BMPR1A 0.844753502512594 3.73722278438606e-05 -0.769696479269679 2.04474538839979e-07 miRanda -0.202151232698844 6.83112462517003e-09 NA NA NA hsa-miR-186-5p BMPR1A 1.47445398888668 3.0781726595413e-15 -0.769696479269679 2.04474538839979e-07 MirTarget -0.224056939288219 1.83929274683298e-09 NA NA NA hsa-miR-589-5p BMPR1A 1.71990116752371 8.310889042056e-14 -0.769696479269679 2.04474538839979e-07 MirTarget -0.117858616604392 0.000115436246469953 NA NA NA hsa-miR-942-5p BMPR1A 2.35195531153712 5.45059325728841e-16 -0.769696479269679 2.04474538839979e-07 MirTarget -0.135969732155585 1.06845135905673e-08 NA NA NA hsa-miR-101-3p BMPR1B 0.522819989585461 0.00375627731618038 0.0707965297684667 0.914043396353822 miRNATAP -0.90210571972084 2.80184826114495e-07 NA NA NA hsa-miR-125a-5p BMPR1B 0.599529391575274 0.0102300147180307 0.0707965297684667 0.914043396353822 MirTarget;miRNATAP -0.807051783523079 1.75213413272931e-09 NA NA NA hsa-miR-182-5p BMPR1B 3.53923166221814 5.07781258121574e-21 0.0707965297684667 0.914043396353822 MirTarget -0.352429426701482 9.54099393700212e-06 NA NA NA hsa-miR-205-5p BMPR1B 4.1389800495524 2.05488295686453e-12 0.0707965297684667 0.914043396353822 miRNATAP -0.145489854588743 0.00537234614703736 NA NA NA hsa-miR-26b-5p BMPR1B 0.885393662798425 3.2116297961629e-06 0.0707965297684667 0.914043396353822 mirMAP -0.53030485705377 0.00145841207417321 NA NA NA hsa-miR-330-3p BMPR1B 0.876747334239085 0.00073709016089703 0.0707965297684667 0.914043396353822 mirMAP -0.64524174638227 8.45898404828024e-08 NA NA NA hsa-miR-429 BMPR1B 4.48815175680773 2.44117492218206e-17 0.0707965297684667 0.914043396353822 miRNATAP -0.32745235892597 6.75303195574634e-09 NA NA NA hsa-miR-582-5p BMPR1B 0.609226359812689 0.032988717891497 0.0707965297684667 0.914043396353822 mirMAP;miRNATAP -0.2913092235054 0.00879653271190915 NA NA NA hsa-let-7a-3p BMPR2 1.42015538786275 7.03375209382654e-13 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.152599783592152 7.93471191590871e-06 NA NA NA hsa-let-7f-1-3p BMPR2 1.55054488387679 7.31326775537952e-11 -0.58530303628062 4.05328570423415e-05 MirTarget -0.120307970421237 4.01438554279305e-05 NA NA NA hsa-miR-103a-2-5p BMPR2 2.47599305985086 7.933028987326e-11 -0.58530303628062 4.05328570423415e-05 MirTarget -0.156735069522438 8.7398797773895e-16 NA NA NA hsa-miR-106a-5p BMPR2 2.48882002962836 1.99757727374521e-12 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.13439006659681 4.71463912179543e-13 NA NA NA hsa-miR-106b-5p BMPR2 2.46782146831112 1.36171495805632e-23 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.20224216578274 5.65419838003578e-15 NA NA NA hsa-miR-126-5p BMPR2 0.895338176458417 2.33372756450713e-05 -0.58530303628062 4.05328570423415e-05 mirMAP -0.165449066005832 3.2676073018839e-07 NA NA NA hsa-miR-1271-5p BMPR2 0.970418832993172 0.000609742584380688 -0.58530303628062 4.05328570423415e-05 mirMAP -0.118572818651164 1.01152665195014e-06 NA NA NA hsa-miR-128-3p BMPR2 1.63756041666078 6.79626586407187e-14 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate -0.155559506127877 3.86430519746196e-07 NA NA NA hsa-miR-130a-3p BMPR2 2.02021855058359 1.26427102520415e-11 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.170876589923038 8.54902300867997e-15 NA NA NA hsa-miR-130b-3p BMPR2 3.5350292994509 1.73934183852569e-27 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.132480742234581 1.12126386981845e-11 NA NA NA hsa-miR-136-5p BMPR2 2.09637138292451 1.50140005592201e-10 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.102497292768817 5.91057010070874e-07 NA NA NA hsa-miR-148a-3p BMPR2 1.26728238710376 2.52325607402829e-06 -0.58530303628062 4.05328570423415e-05 mirMAP -0.116655579885245 4.16215411693408e-06 NA NA NA hsa-miR-148b-3p BMPR2 1.97815018171325 6.07715327281595e-26 -0.58530303628062 4.05328570423415e-05 mirMAP -0.217098539189951 2.81982996054712e-10 NA NA NA hsa-miR-16-2-3p BMPR2 2.31623086727196 4.29838149388188e-20 -0.58530303628062 4.05328570423415e-05 mirMAP -0.241072228557309 6.56045989506605e-22 NA NA NA hsa-miR-17-5p BMPR2 3.2710598467455 9.93128340539455e-27 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.207670381733977 5.53123576642946e-25 NA NA NA hsa-miR-181a-5p BMPR2 2.29556023480783 1.8138457900616e-21 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.162789789795827 1.63903044624448e-09 NA NA NA hsa-miR-181b-5p BMPR2 2.49307679431293 3.92829250217627e-20 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.123144226085464 3.57698509578988e-07 NA NA NA hsa-miR-181c-5p BMPR2 1.58587920618301 1.57506918816933e-10 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;miRNATAP -0.122880367144444 6.67276222281815e-06 NA NA NA hsa-miR-185-5p BMPR2 2.34016206907488 1.17481626642022e-26 -0.58530303628062 4.05328570423415e-05 MirTarget -0.206443321614726 1.4604662917038e-12 NA NA NA hsa-miR-186-5p BMPR2 1.47445398888668 3.0781726595413e-15 -0.58530303628062 4.05328570423415e-05 mirMAP -0.324362481564346 6.90612135973666e-21 NA NA NA hsa-miR-192-5p BMPR2 2.69002528723195 1.22990188194432e-16 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate -0.128397743535831 1.9307144568072e-10 NA NA NA hsa-miR-19a-3p BMPR2 3.42309334186656 3.02671914353412e-28 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.217742883172278 6.6262310927576e-29 NA NA NA hsa-miR-19b-3p BMPR2 2.49529833021187 1.57028265846699e-23 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.277864569361708 1.50881970906485e-29 NA NA NA hsa-miR-20a-5p BMPR2 3.15577933619191 4.19753346442454e-25 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.212052258591281 9.32636588986309e-26 NA NA NA hsa-miR-21-5p BMPR2 2.73773305747971 1.38864982139576e-43 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.131652287320736 3.08798777679263e-05 NA NA NA hsa-miR-25-3p BMPR2 1.36472605225697 4.83790725935681e-11 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.250622353088396 3.88435226773423e-15 NA NA NA hsa-miR-26a-2-3p BMPR2 0.823520019989974 0.00017092160823769 -0.58530303628062 4.05328570423415e-05 mirMAP -0.160089489051874 3.84214898400944e-07 NA NA NA hsa-miR-26b-5p BMPR2 0.885393662798425 3.2116297961629e-06 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate -0.170544930909617 2.42578893081629e-06 NA NA NA hsa-miR-29a-5p BMPR2 1.46749674755271 3.34605004270294e-07 -0.58530303628062 4.05328570423415e-05 mirMAP -0.147951331287937 2.48083220467992e-09 NA NA NA hsa-miR-301a-3p BMPR2 2.81024345929638 2.29784847962242e-17 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.18525048532623 8.92556176756374e-20 NA NA NA hsa-miR-30b-5p BMPR2 0.800822374912712 0.000133601914525413 -0.58530303628062 4.05328570423415e-05 mirMAP -0.208948854448395 1.25518734516915e-10 NA NA NA hsa-miR-30c-5p BMPR2 0.778774633108 0.000285599212429136 -0.58530303628062 4.05328570423415e-05 mirMAP -0.221901856860224 2.13739174130527e-12 NA NA NA hsa-miR-30d-5p BMPR2 0.675423997639582 0.00270618816039773 -0.58530303628062 4.05328570423415e-05 mirMAP -0.106831948440534 0.000526281245791836 NA NA NA hsa-miR-30e-5p BMPR2 1.23904909539663 1.35561917122157e-09 -0.58530303628062 4.05328570423415e-05 mirMAP -0.226767367157603 4.55367004734674e-12 NA NA NA hsa-miR-32-3p BMPR2 2.02436999565685 5.94091197945307e-09 -0.58530303628062 4.05328570423415e-05 mirMAP -0.142554817131472 7.47259006817624e-11 NA NA NA hsa-miR-32-5p BMPR2 2.34056473219422 6.24134585974322e-20 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.185360171623864 2.11849459894302e-13 NA NA NA hsa-miR-320a BMPR2 0.438165828017084 0.0390159073347133 -0.58530303628062 4.05328570423415e-05 mirMAP -0.114792800350135 0.000470262582947611 NA NA NA hsa-miR-320b BMPR2 1.55692969039548 1.41071034251915e-08 -0.58530303628062 4.05328570423415e-05 mirMAP -0.100895055393743 4.65320859022884e-05 NA NA NA hsa-miR-342-3p BMPR2 1.49115144672245 1.43879249744621e-07 -0.58530303628062 4.05328570423415e-05 PITA;miRanda;miRNATAP -0.187659669744693 1.0015406600685e-15 NA NA NA hsa-miR-342-5p BMPR2 1.74634624752902 3.89286511372155e-11 -0.58530303628062 4.05328570423415e-05 PITA -0.195566762253857 4.49851211238107e-15 NA NA NA hsa-miR-3607-3p BMPR2 2.68532138541128 5.66716351955047e-14 -0.58530303628062 4.05328570423415e-05 mirMAP;miRNATAP -0.119708962682516 2.74424001919374e-10 NA NA NA hsa-miR-361-5p BMPR2 0.971859117235239 5.30236555707088e-09 -0.58530303628062 4.05328570423415e-05 MirTarget;miRanda;mirMAP;miRNATAP -0.241826033261252 3.38904299290922e-09 NA NA NA hsa-miR-362-3p BMPR2 2.0756816987665 3.89026064579331e-12 -0.58530303628062 4.05328570423415e-05 MirTarget;PITA;miRanda;miRNATAP -0.201623668293698 2.30109419676209e-19 NA NA NA hsa-miR-374a-3p BMPR2 0.533309330504947 0.00192918429705142 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.241041299268692 1.85393256226074e-09 NA NA NA hsa-miR-374a-5p BMPR2 0.484615721953736 0.0042981729815149 -0.58530303628062 4.05328570423415e-05 mirMAP -0.175249946103084 2.03749633026624e-05 NA NA NA hsa-miR-374b-5p BMPR2 0.0654362503857184 0.722673188879465 -0.58530303628062 4.05328570423415e-05 mirMAP -0.154723029815258 4.57180644031775e-05 NA NA NA hsa-miR-378a-5p BMPR2 0.223456081148306 0.386368843153575 -0.58530303628062 4.05328570423415e-05 MirTarget -0.105826927414969 8.35359705651086e-05 NA NA NA hsa-miR-454-3p BMPR2 2.47234127820054 1.12878018736016e-21 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.238011207160195 2.11723827812009e-21 NA NA NA hsa-miR-532-5p BMPR2 1.55697650978597 1.57884735535196e-11 -0.58530303628062 4.05328570423415e-05 PITA -0.238551867133178 4.45231582710634e-17 NA NA NA hsa-miR-590-3p BMPR2 2.59289455139753 1.03200520972022e-21 -0.58530303628062 4.05328570423415e-05 MirTarget;miRanda;mirMAP;miRNATAP -0.210351080269878 2.47174316977252e-18 NA NA NA hsa-miR-590-5p BMPR2 3.18300989862077 2.06813568597893e-26 -0.58530303628062 4.05328570423415e-05 MirTarget;PITA;miRNATAP -0.205931557990053 3.89024781095923e-22 NA NA NA hsa-miR-625-3p BMPR2 1.18769734290812 2.47200238827911e-06 -0.58530303628062 4.05328570423415e-05 mirMAP -0.158762143086924 3.48996581536411e-09 NA NA NA hsa-miR-628-5p BMPR2 0.799263053510813 2.28892357418044e-05 -0.58530303628062 4.05328570423415e-05 MirTarget;PITA;miRNATAP -0.152693375167128 3.14890533041555e-05 NA NA NA hsa-miR-629-5p BMPR2 2.10182419359635 1.51788571125757e-15 -0.58530303628062 4.05328570423415e-05 mirMAP -0.122690028995621 1.17900187204531e-06 NA NA NA hsa-miR-651-5p BMPR2 2.32951837918862 1.62508965949028e-11 -0.58530303628062 4.05328570423415e-05 MirTarget -0.142540412171573 3.95043275025226e-11 NA NA NA hsa-miR-671-5p BMPR2 2.97733652243246 1.21148452344738e-23 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.160465039608908 1.99277235532283e-12 NA NA NA hsa-miR-7-1-3p BMPR2 1.84950311431067 1.25300363397654e-13 -0.58530303628062 4.05328570423415e-05 mirMAP -0.210194689122166 1.01588158730921e-15 NA NA NA hsa-miR-769-5p BMPR2 1.82023760596845 9.6815886564134e-14 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.177508544106453 5.50412874459117e-11 NA NA NA hsa-miR-877-5p BMPR2 2.94916202082736 1.8151927276044e-13 -0.58530303628062 4.05328570423415e-05 MirTarget -0.112421242369306 1.5760150030228e-09 NA NA NA hsa-miR-92a-3p BMPR2 2.06460102658973 1.44784291084757e-19 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;miRNATAP -0.270169549134034 2.25203735602053e-22 NA NA NA hsa-miR-92b-3p BMPR2 1.20409245530001 3.41055816361655e-06 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.131517451998029 5.64955467094799e-07 NA NA NA hsa-miR-93-3p BMPR2 2.85383869771942 5.64481766902125e-23 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate -0.18751024777473 1.09935783855603e-17 NA NA NA hsa-miR-93-5p BMPR2 3.03961860136032 1.11672209617395e-24 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.193491063264994 5.44145207255781e-20 NA NA NA hsa-miR-125a-5p CDKN2B 0.599529391575274 0.0102300147180307 -0.112970149969128 0.832353274540521 miRanda -0.310089305986085 0.00518147219807009 NA NA NA hsa-miR-28-5p CDKN2B 0.230152919654905 0.0742909586754846 -0.112970149969128 0.832353274540521 miRanda -0.668331542152576 0.00118921247732729 NA NA NA hsa-miR-330-3p CDKN2B 0.876747334239085 0.00073709016089703 -0.112970149969128 0.832353274540521 mirMAP;miRNATAP -0.269857955336921 0.0065388859673795 NA NA NA hsa-miR-335-3p CDKN2B 3.08791651139852 5.31309869723517e-12 -0.112970149969128 0.832353274540521 mirMAP -0.121455967054073 0.0304992894193917 NA NA NA hsa-miR-582-5p CDKN2B 0.609226359812689 0.032988717891497 -0.112970149969128 0.832353274540521 miRNATAP -0.437780407212853 1.01848865191063e-06 NA NA NA hsa-miR-671-5p CDKN2B 2.97733652243246 1.21148452344738e-23 -0.112970149969128 0.832353274540521 PITA -0.427729850509145 6.77528914607289e-07 NA NA NA hsa-miR-944 CDKN2B 2.91186649218281 1.31574753528144e-06 -0.112970149969128 0.832353274540521 mirMAP;miRNATAP -0.216243202750685 5.52569916158531e-07 NA NA NA hsa-let-7a-5p CHRD 0.618599506841644 2.76973453058748e-05 -2.00294338701407 4.13701930058193e-07 MirTarget;TargetScan;miRNATAP -0.96195284711057 1.21848690426844e-13 NA NA NA hsa-let-7b-5p CHRD 0.604314269683977 0.00140009936153214 -2.00294338701407 4.13701930058193e-07 MirTarget;miRNATAP -0.710564057795196 1.86692063201555e-12 NA NA NA hsa-let-7d-5p CHRD 1.33236798905207 1.1741085658466e-13 -2.00294338701407 4.13701930058193e-07 MirTarget;miRNATAP -0.720626441965875 3.72703295767659e-12 NA NA NA hsa-let-7e-5p CHRD 0.860104282510173 6.04758298373779e-05 -2.00294338701407 4.13701930058193e-07 MirTarget;miRNATAP -0.237084806829991 0.00886560074677621 NA NA NA hsa-let-7f-5p CHRD 0.495648727272215 0.00355972741198794 -2.00294338701407 4.13701930058193e-07 MirTarget;miRNATAP -0.498606857717912 1.41199841363102e-05 NA NA NA hsa-let-7g-3p CHRD 3.26398061402445 3.96263126107645e-25 -2.00294338701407 4.13701930058193e-07 MirTarget -0.533740709868262 6.82652199328992e-21 NA NA NA hsa-let-7g-5p CHRD 1.20061455355116 1.50237505511483e-12 -2.00294338701407 4.13701930058193e-07 MirTarget;miRNATAP -0.854552642222562 6.0290725983971e-15 NA NA NA hsa-miR-196b-5p CHRD 1.71646270856386 4.37735885910369e-09 -2.00294338701407 4.13701930058193e-07 miRNATAP -0.408226445586944 1.83284559540482e-10 NA NA NA hsa-miR-455-3p CHRD 3.06093594997644 3.54590649799868e-16 -2.00294338701407 4.13701930058193e-07 miRNATAP -0.301725535574875 6.90520704482089e-10 NA NA NA hsa-miR-98-5p CHRD 1.11154309866014 1.24143909012085e-08 -2.00294338701407 4.13701930058193e-07 MirTarget -0.669386112229229 3.89936099536814e-12 NA NA NA hsa-miR-186-5p CREBBP 1.47445398888668 3.0781726595413e-15 -0.451040948976341 0.000687386434761364 mirMAP;miRNATAP -0.14581204925591 1.28616268232458e-05 NA NA NA hsa-miR-26b-5p CREBBP 0.885393662798425 3.2116297961629e-06 -0.451040948976341 0.000687386434761364 miRNATAP -0.128164022830949 0.000145104031692185 NA NA NA hsa-let-7a-5p DCN 0.618599506841644 2.76973453058748e-05 -3.45334496072418 3.0714283501425e-12 MirTarget -1.29955949028783 2.15054923683201e-15 NA NA NA hsa-let-7b-5p DCN 0.604314269683977 0.00140009936153214 -3.45334496072418 3.0714283501425e-12 MirTarget -0.735312761308106 1.28325169508081e-08 NA NA NA hsa-let-7d-5p DCN 1.33236798905207 1.1741085658466e-13 -3.45334496072418 3.0714283501425e-12 MirTarget -1.30966003831062 8.0468390056938e-25 NA NA NA hsa-let-7e-5p DCN 0.860104282510173 6.04758298373779e-05 -3.45334496072418 3.0714283501425e-12 MirTarget -0.607888949600183 8.40952632374267e-08 NA NA NA hsa-let-7f-5p DCN 0.495648727272215 0.00355972741198794 -3.45334496072418 3.0714283501425e-12 MirTarget -0.721094649237192 6.80885340057416e-07 NA NA NA hsa-let-7g-5p DCN 1.20061455355116 1.50237505511483e-12 -3.45334496072418 3.0714283501425e-12 MirTarget -1.36880417070961 6.35488108564248e-24 NA NA NA hsa-miR-181a-5p DCN 2.29556023480783 1.8138457900616e-21 -3.45334496072418 3.0714283501425e-12 MirTarget -0.506710171322978 1.45285801866355e-07 NA NA NA hsa-miR-181b-5p DCN 2.49307679431293 3.92829250217627e-20 -3.45334496072418 3.0714283501425e-12 MirTarget -0.578145379067561 9.73053510952451e-12 NA NA NA hsa-miR-181c-5p DCN 1.58587920618301 1.57506918816933e-10 -3.45334496072418 3.0714283501425e-12 MirTarget -0.503303068283161 1.83070019040477e-07 NA NA NA hsa-miR-181d-5p DCN 1.52204912185579 9.2693319057748e-08 -3.45334496072418 3.0714283501425e-12 MirTarget -0.482885764181953 9.60777067016379e-09 NA NA NA hsa-miR-186-5p DCN 1.47445398888668 3.0781726595413e-15 -3.45334496072418 3.0714283501425e-12 mirMAP -1.22695905339932 8.08140032867963e-24 NA NA NA hsa-miR-3065-5p DCN 2.74629919868982 1.86846589298284e-08 -3.45334496072418 3.0714283501425e-12 mirMAP -0.299460625015316 6.3090350551147e-07 NA NA NA hsa-miR-320a DCN 0.438165828017084 0.0390159073347133 -3.45334496072418 3.0714283501425e-12 miRanda -0.885017857237456 5.63097559308097e-15 NA NA NA hsa-miR-320b DCN 1.55692969039548 1.41071034251915e-08 -3.45334496072418 3.0714283501425e-12 miRanda -0.868290115344502 2.31348822218025e-25 NA NA NA hsa-miR-374b-3p DCN 0.930487774873495 2.74420094310516e-05 -3.45334496072418 3.0714283501425e-12 MirTarget -0.599882155684483 4.65687659545439e-08 NA NA NA hsa-miR-421 DCN 1.17791565395543 6.78526676976629e-06 -3.45334496072418 3.0714283501425e-12 miRanda -0.712973490983918 4.07124694193684e-15 NA NA NA hsa-miR-491-5p DCN 0.615770352820862 0.0418295628761654 -3.45334496072418 3.0714283501425e-12 miRanda -0.484525900445249 1.866547904204e-08 NA NA NA hsa-miR-501-5p DCN 1.93654809410041 1.3779381780759e-10 -3.45334496072418 3.0714283501425e-12 mirMAP -0.487796424451936 1.69817707392228e-09 NA NA NA hsa-miR-590-3p DCN 2.59289455139753 1.03200520972022e-21 -3.45334496072418 3.0714283501425e-12 MirTarget;PITA;miRanda;mirMAP -0.809280815704104 1.40193401668637e-21 NA NA NA hsa-miR-7-1-3p DCN 1.84950311431067 1.25300363397654e-13 -3.45334496072418 3.0714283501425e-12 mirMAP -0.819180541083217 6.65494529445234e-19 NA NA NA hsa-miR-944 DCN 2.91186649218281 1.31574753528144e-06 -3.45334496072418 3.0714283501425e-12 mirMAP -0.316956220240754 4.00458729865207e-15 NA NA NA hsa-miR-98-5p DCN 1.11154309866014 1.24143909012085e-08 -3.45334496072418 3.0714283501425e-12 MirTarget -1.02545685526001 1.91396489138775e-17 NA NA NA hsa-miR-140-5p EP300 0.844753502512594 3.73722278438606e-05 -0.259813561364416 0.130645976324069 miRNAWalker2_validate -0.116180580124631 0.0041461159891489 NA NA NA hsa-miR-142-5p EP300 1.17581605694506 0.0018174701991234 -0.259813561364416 0.130645976324069 PITA;mirMAP;miRNATAP -0.111374437902145 2.72973348003874e-07 23342264 In contrast to the mouse p300 gene the human p300 gene was not found to be a target for miR-142-5p B cell lymphoma hsa-miR-186-5p EP300 1.47445398888668 3.0781726595413e-15 -0.259813561364416 0.130645976324069 miRNATAP -0.111237131829924 0.0103888927623672 NA NA NA hsa-miR-193b-3p EP300 2.25711804611899 4.1940744806631e-14 -0.259813561364416 0.130645976324069 miRNAWalker2_validate -0.105745678811168 8.10977033783005e-05 NA NA NA hsa-miR-22-3p EP300 1.21545661147757 1.61670170137775e-13 -0.259813561364416 0.130645976324069 MirTarget;miRNATAP -0.202351996320887 4.21898434047145e-05 NA NA NA hsa-miR-29b-1-5p EP300 1.55384379072167 4.76870585070176e-05 -0.259813561364416 0.130645976324069 MirTarget -0.128437592094259 1.17066262616741e-08 NA NA NA hsa-miR-342-3p EP300 1.49115144672245 1.43879249744621e-07 -0.259813561364416 0.130645976324069 MirTarget;PITA;miRanda;miRNATAP -0.216290263558714 1.26951899192842e-14 NA NA NA hsa-miR-361-3p EP300 1.07367425434318 1.73142774168958e-09 -0.259813561364416 0.130645976324069 PITA -0.267683295831071 4.11859386761575e-09 NA NA NA hsa-miR-224-3p FST 1.87536386559317 6.15140969394846e-05 -0.85561775253026 0.0979044797352961 MirTarget -0.203729613551838 0.000229580777245475 NA NA NA hsa-miR-769-5p FST 1.82023760596845 9.6815886564134e-14 -0.85561775253026 0.0979044797352961 MirTarget;miRNATAP -0.234679647471152 0.0188155694733484 NA NA NA hsa-miR-129-5p GDF5 -0.524170159980738 0.222582956006346 -0.0453868434412796 0.928870355717812 miRanda -0.165047272235026 0.00463078852062911 NA NA NA hsa-miR-335-5p GDF5 1.77247705492746 2.22457658872091e-06 -0.0453868434412796 0.928870355717812 miRNAWalker2_validate -0.150401827113431 0.02051031631242 NA NA NA hsa-miR-590-5p GDF5 3.18300989862077 2.06813568597893e-26 -0.0453868434412796 0.928870355717812 miRanda -0.250751177480169 0.00154618702172687 NA NA NA hsa-let-7d-5p GDF6 1.33236798905207 1.1741085658466e-13 -1.13505992050111 0.0279057480958108 MirTarget;miRNATAP -0.827037779500331 7.94176953140371e-10 NA NA NA hsa-let-7f-5p GDF6 0.495648727272215 0.00355972741198794 -1.13505992050111 0.0279057480958108 MirTarget;miRNATAP -0.496103897849871 0.000851574675341571 NA NA NA hsa-let-7g-5p GDF6 1.20061455355116 1.50237505511483e-12 -1.13505992050111 0.0279057480958108 MirTarget;miRNATAP -0.965042822277671 1.23975458351993e-11 NA NA NA hsa-miR-125a-3p GDF6 1.24490295132072 5.26925231010328e-06 -1.13505992050111 0.0279057480958108 miRanda -0.237939076878051 0.0089491759493519 NA NA NA hsa-miR-141-3p GDF6 5.02396127982626 2.19224509139725e-24 -1.13505992050111 0.0279057480958108 TargetScan -0.341173884857515 2.2217799210351e-13 NA NA NA hsa-miR-141-5p GDF6 3.81419396518882 3.21977359736126e-18 -1.13505992050111 0.0279057480958108 mirMAP -0.359939094243448 1.66528449741244e-11 NA NA NA hsa-miR-193a-3p GDF6 1.60460546928078 2.86169793322984e-07 -1.13505992050111 0.0279057480958108 miRanda -0.306692810780015 9.74048617805209e-05 NA NA NA hsa-miR-200b-3p GDF6 3.78235093249346 3.18343003239465e-14 -1.13505992050111 0.0279057480958108 TargetScan -0.293866844040767 7.1280401489341e-10 NA NA NA hsa-miR-205-5p GDF6 4.1389800495524 2.05488295686453e-12 -1.13505992050111 0.0279057480958108 miRNATAP -0.171161056724495 3.00345054906495e-05 NA NA NA hsa-miR-23a-5p GDF6 1.46491071577368 0.000241866585858992 -1.13505992050111 0.0279057480958108 miRNATAP -0.2179816387183 0.000991679833494399 NA NA NA hsa-miR-30d-3p GDF6 0.977747550180601 4.3048212205381e-05 -1.13505992050111 0.0279057480958108 miRNATAP -0.567834803094083 3.71753630877376e-08 NA NA NA hsa-miR-324-5p GDF6 2.95683728155095 1.32960514360912e-20 -1.13505992050111 0.0279057480958108 miRanda -0.527333487445525 5.79720902220909e-13 NA NA NA hsa-miR-330-3p GDF6 0.876747334239085 0.00073709016089703 -1.13505992050111 0.0279057480958108 PITA;miRNATAP -0.434086776266481 5.5008849526711e-06 NA NA NA hsa-miR-339-5p GDF6 2.68710938429893 3.03134080808154e-16 -1.13505992050111 0.0279057480958108 miRanda -0.486069529133264 1.25211647052908e-11 NA NA NA hsa-miR-3607-3p GDF6 2.68532138541128 5.66716351955047e-14 -1.13505992050111 0.0279057480958108 MirTarget;miRNATAP -0.293210070673825 2.3457967080501e-05 NA NA NA hsa-miR-429 GDF6 4.48815175680773 2.44117492218206e-17 -1.13505992050111 0.0279057480958108 PITA;miRanda;miRNATAP -0.282911581669513 1.86916527400181e-10 NA NA NA hsa-miR-532-3p GDF6 1.96631878320218 4.53421954361695e-13 -1.13505992050111 0.0279057480958108 PITA;miRNATAP -0.731174627698996 2.84429193683468e-17 NA NA NA hsa-miR-589-3p GDF6 2.51971841868825 2.39125940264107e-11 -1.13505992050111 0.0279057480958108 MirTarget -0.450064572426505 5.154786454781e-10 NA NA NA hsa-miR-590-3p GDF6 2.59289455139753 1.03200520972022e-21 -1.13505992050111 0.0279057480958108 miRanda;mirMAP -0.553072945689467 4.80578078950766e-10 NA NA NA hsa-miR-944 GDF6 2.91186649218281 1.31574753528144e-06 -1.13505992050111 0.0279057480958108 PITA;mirMAP;miRNATAP -0.174156006437381 3.51134149955132e-05 NA NA NA hsa-miR-98-5p GDF6 1.11154309866014 1.24143909012085e-08 -1.13505992050111 0.0279057480958108 MirTarget -0.786793037725904 3.05451373036232e-10 NA NA NA hsa-miR-100-5p ID1 -1.48442967087177 1.5610956769298e-05 -0.110499119997154 0.797833760755636 miRNAWalker2_validate -0.385725210844168 5.78825527456675e-11 NA NA NA hsa-miR-195-3p ID1 -0.658653229922836 0.0142127125129199 -0.110499119997154 0.797833760755636 MirTarget;miRNATAP -0.224788053565875 0.00448313807537416 NA NA NA hsa-miR-29a-3p ID1 -0.35074463683376 0.161238718982428 -0.110499119997154 0.797833760755636 MirTarget -0.299094282117428 0.000338656572077568 NA NA NA hsa-miR-338-5p ID1 -0.577691606146419 0.0472212680542825 -0.110499119997154 0.797833760755636 MirTarget;PITA;miRNATAP -0.27813670748364 0.00011318808154234 NA NA NA hsa-let-7a-3p ID2 1.42015538786275 7.03375209382654e-13 -1.54654357209616 1.27444108702092e-06 miRNATAP -0.358646681831114 3.17261659036183e-06 NA NA NA hsa-let-7b-3p ID2 0.868207752019623 1.30460056774366e-05 -1.54654357209616 1.27444108702092e-06 miRNATAP -0.283914204742337 0.000289181687117768 NA NA NA hsa-miR-19a-3p ID2 3.42309334186656 3.02671914353412e-28 -1.54654357209616 1.27444108702092e-06 MirTarget;miRNATAP -0.16516373144464 0.000436575283437063 NA NA NA hsa-miR-19b-3p ID2 2.49529833021187 1.57028265846699e-23 -1.54654357209616 1.27444108702092e-06 MirTarget;miRNATAP -0.157910549016721 0.0079766133260792 NA NA NA hsa-miR-27a-3p ID2 1.66542180327138 4.93775737894805e-13 -1.54654357209616 1.27444108702092e-06 MirTarget;miRNATAP -0.415869746928321 1.64119825970062e-10 NA NA NA hsa-miR-338-3p ID2 0.453166438193782 0.144583389707558 -1.54654357209616 1.27444108702092e-06 miRanda -0.150326580770318 0.00285978135046781 NA NA NA hsa-miR-362-3p ID2 2.0756816987665 3.89026064579331e-12 -1.54654357209616 1.27444108702092e-06 miRanda;mirMAP -0.116379520217967 0.0276177708816772 NA NA NA hsa-miR-455-3p ID2 3.06093594997644 3.54590649799868e-16 -1.54654357209616 1.27444108702092e-06 MirTarget;PITA;miRNATAP -0.212973966922076 7.67722071909368e-08 NA NA NA hsa-miR-590-3p ID2 2.59289455139753 1.03200520972022e-21 -1.54654357209616 1.27444108702092e-06 miRanda -0.168489146813562 0.00286466301670518 NA NA NA hsa-miR-9-5p ID2 1.02304182473283 0.042901377604859 -1.54654357209616 1.27444108702092e-06 miRNAWalker2_validate;miRTarBase -0.114949551075085 0.000184259502532564 NA NA NA hsa-miR-199a-5p ID3 0.592984035153911 0.0674836634175293 -0.668867241501022 0.0319478785845466 miRanda -0.128872209935146 0.00568440462361388 NA NA NA hsa-miR-590-3p ID3 2.59289455139753 1.03200520972022e-21 -0.668867241501022 0.0319478785845466 miRanda -0.109744303850252 0.0449349229304456 NA NA NA hsa-miR-142-3p ID4 2.75247908790621 1.45636065474764e-12 -2.19244271630349 1.1972935480644e-06 miRanda -0.460665975991198 4.60334192218307e-18 NA NA NA hsa-miR-186-5p ID4 1.47445398888668 3.0781726595413e-15 -2.19244271630349 1.1972935480644e-06 miRNAWalker2_validate;mirMAP -0.307761087492666 0.00782443483978866 NA NA NA hsa-miR-27a-3p ID4 1.66542180327138 4.93775737894805e-13 -2.19244271630349 1.1972935480644e-06 miRNAWalker2_validate -0.761594375751829 3.79037597365654e-17 NA NA NA hsa-miR-338-5p ID4 -0.577691606146419 0.0472212680542825 -2.19244271630349 1.1972935480644e-06 MirTarget;PITA -0.340335633418553 8.02781206784224e-06 NA NA NA hsa-miR-339-5p ID4 2.68710938429893 3.03134080808154e-16 -2.19244271630349 1.1972935480644e-06 miRanda -0.302490827585859 2.57251162839987e-06 NA NA NA hsa-miR-340-5p ID4 0.30282999308409 0.157744789519131 -2.19244271630349 1.1972935480644e-06 miRNAWalker2_validate -0.26089220291984 0.0122953256923104 NA NA NA hsa-miR-342-3p ID4 1.49115144672245 1.43879249744621e-07 -2.19244271630349 1.1972935480644e-06 MirTarget;PITA;miRanda -0.423795960077892 2.52792204179537e-08 24475217 miR 342 regulates BRCA1 expression through modulation of ID4 in breast cancer; To investigate at functional level the role of miR-342 in the pathogenesis of breast cancer we focused our attention on its "in silico" predicted putative target gene ID4 a transcription factor of the helix-loop-helix protein family whose expression is inversely correlated with that of ER; We functionally validated the interaction between ID4 and miR-342 in a reporter Luciferase system; Based on these findings we hypothesized that regulation of ID4 mediated by miR-342 could be involved in the pathogenesis of breast cancer by downregulating BRCA1 expression; Overexpression of miR-342 in these cells reduced ID4 and increased BRCA1 expression supporting a possible role of this mechanism in breast cancer; In the ER-positive MCF7 and in the BRCA1-mutant HCC1937 cell lines miR-342 over-expression only reduced ID4 breast cancer hsa-miR-362-3p ID4 2.0756816987665 3.89026064579331e-12 -2.19244271630349 1.1972935480644e-06 miRanda -0.230186658187485 0.00201476079922632 NA NA NA hsa-miR-576-5p ID4 2.20467023993664 3.4053475193793e-19 -2.19244271630349 1.1972935480644e-06 mirMAP -0.354916719517745 3.56280575026565e-05 NA NA NA hsa-miR-589-3p ID4 2.51971841868825 2.39125940264107e-11 -2.19244271630349 1.1972935480644e-06 MirTarget -0.30714308316169 2.01509553306658e-06 NA NA NA hsa-miR-590-3p ID4 2.59289455139753 1.03200520972022e-21 -2.19244271630349 1.1972935480644e-06 miRNAWalker2_validate;miRanda -0.428819214035375 5.64046127846961e-08 NA NA NA hsa-miR-590-5p ID4 3.18300989862077 2.06813568597893e-26 -2.19244271630349 1.1972935480644e-06 miRanda -0.331298264359514 2.88646550276068e-06 NA NA NA hsa-miR-629-3p ID4 2.36570947321815 1.33458201201618e-11 -2.19244271630349 1.1972935480644e-06 MirTarget -0.427422642109497 4.58202078936884e-10 NA NA NA hsa-miR-125a-5p IFNG 0.599529391575274 0.0102300147180307 0.730652903235741 0.241316232029331 miRanda -0.796445342539644 4.0129599473011e-10 NA NA NA hsa-miR-429 IFNG 4.48815175680773 2.44117492218206e-17 0.730652903235741 0.241316232029331 miRanda -0.33666497744537 3.26614656153225e-10 NA NA NA hsa-miR-10b-5p INHBA -0.155951595811628 0.555006386998027 1.44116109080829 0.0141935130251973 miRNAWalker2_validate -0.806261626502605 1.88811148190204e-14 NA NA NA hsa-miR-126-5p INHBA 0.895338176458417 2.33372756450713e-05 1.44116109080829 0.0141935130251973 mirMAP -0.271946488900207 0.0438626847332565 NA NA NA hsa-miR-129-5p INHBA -0.524170159980738 0.222582956006346 1.44116109080829 0.0141935130251973 miRanda -0.217462863610452 0.00127865658512647 NA NA NA hsa-miR-148b-3p INHBA 1.97815018171325 6.07715327281595e-26 1.44116109080829 0.0141935130251973 miRNAWalker2_validate -0.815256633903519 9.54994164398835e-09 NA NA NA hsa-miR-181c-5p INHBA 1.58587920618301 1.57506918816933e-10 1.44116109080829 0.0141935130251973 mirMAP -0.484134229816087 1.62177913258834e-05 NA NA NA hsa-miR-200b-3p INHBA 3.78235093249346 3.18343003239465e-14 1.44116109080829 0.0141935130251973 TargetScan -0.408352816068364 2.84386065824124e-14 NA NA NA hsa-miR-224-3p INHBA 1.87536386559317 6.15140969394846e-05 1.44116109080829 0.0141935130251973 mirMAP -0.25047555438214 6.84234124400527e-05 NA NA NA hsa-miR-23b-3p INHBA -0.251132426825047 0.150200321210792 1.44116109080829 0.0141935130251973 mirMAP -0.516405683758728 0.00182807381264671 NA NA NA hsa-miR-26b-5p INHBA 0.885393662798425 3.2116297961629e-06 1.44116109080829 0.0141935130251973 mirMAP -0.478405936924044 0.00140500867887125 NA NA NA hsa-miR-30b-5p INHBA 0.800822374912712 0.000133601914525413 1.44116109080829 0.0141935130251973 mirMAP -0.908128346719846 9.11214995758966e-12 NA NA NA hsa-miR-30c-5p INHBA 0.778774633108 0.000285599212429136 1.44116109080829 0.0141935130251973 mirMAP -1.1265541412423 1.16435194721796e-18 NA NA NA hsa-miR-30d-5p INHBA 0.675423997639582 0.00270618816039773 1.44116109080829 0.0141935130251973 mirMAP -1.28724105324569 3.72358672438813e-27 NA NA NA hsa-miR-30e-5p INHBA 1.23904909539663 1.35561917122157e-09 1.44116109080829 0.0141935130251973 mirMAP -1.37027336840008 5.34980288081758e-26 NA NA NA hsa-miR-335-3p INHBA 3.08791651139852 5.31309869723517e-12 1.44116109080829 0.0141935130251973 mirMAP -0.126288301627569 0.0418533456287017 NA NA NA hsa-miR-3607-3p INHBA 2.68532138541128 5.66716351955047e-14 1.44116109080829 0.0141935130251973 mirMAP -0.274602968013892 0.000530682371959114 NA NA NA hsa-miR-374a-5p INHBA 0.484615721953736 0.0042981729815149 1.44116109080829 0.0141935130251973 mirMAP -0.426510644329452 0.0122666578331899 NA NA NA hsa-miR-421 INHBA 1.17791565395543 6.78526676976629e-06 1.44116109080829 0.0141935130251973 miRanda -0.280376056517452 0.00980185971427785 NA NA NA hsa-miR-664a-3p INHBA 0.634721925861133 0.00520070178640421 1.44116109080829 0.0141935130251973 mirMAP -1.09887225313958 7.9941479643233e-20 NA NA NA hsa-miR-944 INHBA 2.91186649218281 1.31574753528144e-06 1.44116109080829 0.0141935130251973 mirMAP -0.128642141599637 0.00765396161708449 NA NA NA hsa-let-7a-3p INHBB 1.42015538786275 7.03375209382654e-13 -1.63532338824153 1.3666012569742e-06 mirMAP -0.204744240892032 0.0129414173763245 NA NA NA hsa-let-7f-1-3p INHBB 1.55054488387679 7.31326775537952e-11 -1.63532338824153 1.3666012569742e-06 mirMAP -0.341078181173028 1.02058839482832e-06 NA NA NA hsa-miR-130a-3p INHBB 2.02021855058359 1.26427102520415e-11 -1.63532338824153 1.3666012569742e-06 miRNATAP -0.16018600457944 0.00317050710489168 NA NA NA hsa-miR-130b-3p INHBB 3.5350292994509 1.73934183852569e-27 -1.63532338824153 1.3666012569742e-06 miRNATAP -0.271254000039119 7.97624325885017e-09 NA NA NA hsa-miR-130b-5p INHBB 2.9963110846538 1.98883029416455e-18 -1.63532338824153 1.3666012569742e-06 mirMAP -0.273996188391857 5.56934793236335e-09 NA NA NA hsa-miR-149-5p INHBB 2.94200492826326 4.93436498919036e-14 -1.63532338824153 1.3666012569742e-06 miRNATAP -0.140398504873572 0.000621051040123973 NA NA NA hsa-miR-19a-3p INHBB 3.42309334186656 3.02671914353412e-28 -1.63532338824153 1.3666012569742e-06 miRNATAP -0.32913590467041 1.60387513054903e-11 NA NA NA hsa-miR-19b-3p INHBB 2.49529833021187 1.57028265846699e-23 -1.63532338824153 1.3666012569742e-06 miRNATAP -0.398848320288268 1.12916662194947e-10 NA NA NA hsa-miR-26b-5p INHBB 0.885393662798425 3.2116297961629e-06 -1.63532338824153 1.3666012569742e-06 miRNATAP -0.351056473472899 5.27683303965669e-05 NA NA NA hsa-miR-28-5p INHBB 0.230152919654905 0.0742909586754846 -1.63532338824153 1.3666012569742e-06 miRanda -0.32653293249237 0.0140155929201986 NA NA NA hsa-miR-301a-3p INHBB 2.81024345929638 2.29784847962242e-17 -1.63532338824153 1.3666012569742e-06 miRNATAP -0.279347170404905 2.57840590263761e-08 NA NA NA hsa-miR-32-3p INHBB 2.02436999565685 5.94091197945307e-09 -1.63532338824153 1.3666012569742e-06 mirMAP -0.335203686543095 1.60532551957109e-10 NA NA NA hsa-miR-34a-5p INHBB 1.9016323452565 1.43092834643601e-14 -1.63532338824153 1.3666012569742e-06 miRNATAP -0.243244739481652 0.000182207922114652 NA NA NA hsa-miR-3614-5p INHBB 2.17736331059655 2.19144831318484e-08 -1.63532338824153 1.3666012569742e-06 miRNATAP -0.245087335705526 9.99097884532659e-09 NA NA NA hsa-miR-362-3p INHBB 2.0756816987665 3.89026064579331e-12 -1.63532338824153 1.3666012569742e-06 miRanda;miRNATAP -0.243712303639009 1.15039248347425e-05 NA NA NA hsa-miR-374b-5p INHBB 0.0654362503857184 0.722673188879465 -1.63532338824153 1.3666012569742e-06 miRNATAP -0.235528975838002 0.00990430687531157 NA NA NA hsa-miR-429 INHBB 4.48815175680773 2.44117492218206e-17 -1.63532338824153 1.3666012569742e-06 miRNATAP -0.162190748609925 4.3054572606026e-08 NA NA NA hsa-miR-454-3p INHBB 2.47234127820054 1.12878018736016e-21 -1.63532338824153 1.3666012569742e-06 miRNATAP -0.338756999515169 4.81796734200787e-08 NA NA NA hsa-miR-590-3p INHBB 2.59289455139753 1.03200520972022e-21 -1.63532338824153 1.3666012569742e-06 miRanda -0.37015558240971 3.17894450070833e-10 NA NA NA hsa-miR-590-5p INHBB 3.18300989862077 2.06813568597893e-26 -1.63532338824153 1.3666012569742e-06 miRanda -0.335780497000269 1.58317465143947e-10 NA NA NA hsa-miR-940 INHBB 3.21011374578759 2.7923171128495e-14 -1.63532338824153 1.3666012569742e-06 PITA -0.187303086119814 5.51154971984127e-06 NA NA NA hsa-miR-944 INHBB 2.91186649218281 1.31574753528144e-06 -1.63532338824153 1.3666012569742e-06 PITA;miRNATAP -0.19059393272461 3.4311001715411e-12 NA NA NA hsa-miR-98-5p INHBE 1.11154309866014 1.24143909012085e-08 0.257947331869918 0.519034808899879 miRNAWalker2_validate -0.205272748166319 0.0373186730674838 NA NA NA hsa-miR-148a-5p LEFTY2 1.16173838132242 0.000148929299881612 -2.32949736286878 0.000540687666643085 MirTarget -0.316285074907565 0.00294990347774112 NA NA NA hsa-miR-192-5p LEFTY2 2.69002528723195 1.22990188194432e-16 -2.32949736286878 0.000540687666643085 MirTarget -0.868578683242975 7.8461987323438e-21 NA NA NA hsa-miR-215-5p LEFTY2 2.30755467422978 2.38476032118039e-06 -2.32949736286878 0.000540687666643085 MirTarget -0.450244226121904 1.44871970768894e-11 NA NA NA hsa-miR-339-5p LEFTY2 2.68710938429893 3.03134080808154e-16 -2.32949736286878 0.000540687666643085 miRanda -0.609964305902684 9.49947489064681e-11 NA NA NA hsa-miR-421 LEFTY2 1.17791565395543 6.78526676976629e-06 -2.32949736286878 0.000540687666643085 miRanda -0.737100340846659 1.87476863262713e-09 NA NA NA hsa-miR-625-5p LEFTY2 1.42540152147292 1.95797147911206e-06 -2.32949736286878 0.000540687666643085 MirTarget -0.619017618032693 1.43593974880806e-07 NA NA NA hsa-miR-10a-5p LTBP1 1.15016989191194 0.00372037233992369 -1.09891861471167 0.000129213237016863 MirTarget -0.226226380050575 4.8158122765504e-11 NA NA NA hsa-miR-10b-5p LTBP1 -0.155951595811628 0.555006386998027 -1.09891861471167 0.000129213237016863 MirTarget -0.261197728831087 7.14223213634178e-07 NA NA NA hsa-miR-128-3p LTBP1 1.63756041666078 6.79626586407187e-14 -1.09891861471167 0.000129213237016863 MirTarget -0.412140262331824 1.54227064592939e-11 NA NA NA hsa-miR-141-3p LTBP1 5.02396127982626 2.19224509139725e-24 -1.09891861471167 0.000129213237016863 MirTarget -0.211434558427624 2.47291192802919e-16 NA NA NA hsa-miR-148a-3p LTBP1 1.26728238710376 2.52325607402829e-06 -1.09891861471167 0.000129213237016863 MirTarget;miRNATAP -0.12265161474581 0.0174334182208214 NA NA NA hsa-miR-148b-3p LTBP1 1.97815018171325 6.07715327281595e-26 -1.09891861471167 0.000129213237016863 MirTarget -0.492078726232719 9.69882863551575e-13 NA NA NA hsa-miR-200a-3p LTBP1 4.59434485520731 6.38952518573476e-18 -1.09891861471167 0.000129213237016863 MirTarget -0.190989324223775 4.36379137798771e-15 NA NA NA hsa-miR-224-3p LTBP1 1.87536386559317 6.15140969394846e-05 -1.09891861471167 0.000129213237016863 MirTarget -0.142907517941983 3.37955716586515e-06 NA NA NA hsa-miR-26b-5p LTBP1 0.885393662798425 3.2116297961629e-06 -1.09891861471167 0.000129213237016863 miRNATAP -0.241254433816051 0.0010237110620745 NA NA NA hsa-miR-27a-5p LTBP1 0.0545598990316276 0.869091561924187 -1.09891861471167 0.000129213237016863 MirTarget -0.10623657618108 0.0121865159830245 NA NA NA hsa-miR-429 LTBP1 4.48815175680773 2.44117492218206e-17 -1.09891861471167 0.000129213237016863 miRanda;miRNATAP -0.168601076908171 9.2496224768742e-12 NA NA NA hsa-miR-491-5p LTBP1 0.615770352820862 0.0418295628761654 -1.09891861471167 0.000129213237016863 miRanda -0.110815104439921 0.0257982316406549 NA NA NA hsa-miR-590-3p LTBP1 2.59289455139753 1.03200520972022e-21 -1.09891861471167 0.000129213237016863 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.281039340621276 1.72921596690055e-08 NA NA NA hsa-miR-590-5p LTBP1 3.18300989862077 2.06813568597893e-26 -1.09891861471167 0.000129213237016863 miRanda -0.232188014943221 1.95959400254749e-07 NA NA NA hsa-miR-7-1-3p LTBP1 1.84950311431067 1.25300363397654e-13 -1.09891861471167 0.000129213237016863 MirTarget -0.312837292228769 5.9969993387663e-09 NA NA NA hsa-miR-92a-3p LTBP1 2.06460102658973 1.44784291084757e-19 -1.09891861471167 0.000129213237016863 miRNAWalker2_validate -0.438803903356481 1.65584072071656e-14 NA NA NA hsa-miR-140-3p MAPK1 0.0608890720479334 0.727716871248724 -0.300413846088826 0.0202503240217449 PITA;miRNATAP -0.126850675206772 0.000457308593536618 NA NA NA hsa-miR-30c-5p MAPK1 0.778774633108 0.000285599212429136 -0.300413846088826 0.0202503240217449 mirMAP -0.161696427374548 1.83237959021178e-08 NA NA NA hsa-miR-30e-5p MAPK1 1.23904909539663 1.35561917122157e-09 -0.300413846088826 0.0202503240217449 mirMAP -0.123981973754552 3.68994437193015e-05 NA NA NA hsa-miR-34a-5p MAPK1 1.9016323452565 1.43092834643601e-14 -0.300413846088826 0.0202503240217449 mirMAP -0.113934200811126 2.89029232507908e-06 NA NA NA hsa-let-7f-5p MYC 0.495648727272215 0.00355972741198794 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.302610362502413 0.00593577090066522 NA NA NA hsa-let-7g-5p MYC 1.20061455355116 1.50237505511483e-12 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.647634835001101 8.67569135821405e-10 NA NA NA hsa-miR-320a MYC 0.438165828017084 0.0390159073347133 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.270203083250914 0.00203008366284758 25736597 Furthermore progesterone P4 promoted the expression of miR-320a by repressing c-Myc expression while estrogen E2 exerted the opposite effect breast cancer hsa-miR-320b MYC 1.55692969039548 1.41071034251915e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.211227042104883 0.00142753396089349 26487644 miR 320b suppresses cell proliferation by targeting c Myc in human colorectal cancer cells; Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo while c-MYC was identified as a target gene of miR-320b in CRC; Furthermore it was found that up-regulation of c-Myc can attenuate the effects induced by miR-320b; Our identification of c-MYC as a target gene of miR-320b provides new insights into the pathophysiology of CRC proliferation and identifies miR-320b as a novel therapeutic target for the treatment of CRC colorectal cancer hsa-miR-335-5p MYC 1.77247705492746 2.22457658872091e-06 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.15527675337735 0.00141118517916367 NA NA NA hsa-miR-34a-5p MYC 1.9016323452565 1.43092834643601e-14 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.359767953473847 5.62932761832786e-07 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-423-5p MYC 0.963563145758616 9.86109015204915e-07 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.592117097378242 1.10389937335588e-10 NA NA NA hsa-miR-429 MYC 4.48815175680773 2.44117492218206e-17 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.269400502460394 6.09134482841112e-17 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC 1.48254348878737 3.23019501613577e-09 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.254793177391621 0.000439915184612437 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-miR-98-5p MYC 1.11154309866014 1.24143909012085e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.602921793997467 5.7325871539819e-11 NA NA NA hsa-miR-146b-5p NODAL 1.75587235896724 1.15724631266659e-07 -0.187729794216025 0.58961983639629 miRanda -0.358145356333827 1.94994706382146e-13 NA NA NA hsa-miR-101-3p NOG 0.522819989585461 0.00375627731618038 -1.04996957338848 0.0827224388167783 miRNATAP -0.349607670488129 0.0334871174365726 NA NA NA hsa-miR-148b-3p NOG 1.97815018171325 6.07715327281595e-26 -1.04996957338848 0.0827224388167783 MirTarget -0.708032615499654 1.42843964112713e-06 NA NA NA hsa-miR-186-5p NOG 1.47445398888668 3.0781726595413e-15 -1.04996957338848 0.0827224388167783 MirTarget;miRNATAP -0.574515041812962 0.000167076298016788 NA NA NA hsa-miR-200b-3p NOG 3.78235093249346 3.18343003239465e-14 -1.04996957338848 0.0827224388167783 MirTarget;TargetScan -0.308168227388684 3.9233328304032e-08 NA NA NA hsa-miR-200c-3p NOG 3.50132673580082 2.42716349086937e-15 -1.04996957338848 0.0827224388167783 MirTarget;miRNATAP -0.376049889176797 2.18212060301929e-09 NA NA NA hsa-miR-26b-3p NOG 2.18464160365372 2.11543189388328e-18 -1.04996957338848 0.0827224388167783 MirTarget -0.371766556975879 0.000976875158835306 NA NA NA hsa-miR-3607-3p NOG 2.68532138541128 5.66716351955047e-14 -1.04996957338848 0.0827224388167783 MirTarget;miRNATAP -0.237259666257936 0.00365848495964816 NA NA NA hsa-miR-429 NOG 4.48815175680773 2.44117492218206e-17 -1.04996957338848 0.0827224388167783 MirTarget;PITA;miRanda;miRNATAP -0.255898504627446 1.09673461633081e-06 NA NA NA hsa-miR-582-3p NOG 0.00876844181512659 0.977126166214707 -1.04996957338848 0.0827224388167783 PITA;miRNATAP -0.486313947844228 3.15417877831524e-07 NA NA NA hsa-miR-141-3p PITX2 5.02396127982626 2.19224509139725e-24 -2.22753708360439 1.34545225235821e-06 TargetScan;miRNATAP -0.274614578689398 8.14562643219687e-11 NA NA NA hsa-miR-142-3p PITX2 2.75247908790621 1.45636065474764e-12 -2.22753708360439 1.34545225235821e-06 miRanda -0.198521548714209 0.000421605794492399 NA NA NA hsa-miR-200a-3p PITX2 4.59434485520731 6.38952518573476e-18 -2.22753708360439 1.34545225235821e-06 miRNATAP -0.191061820111295 2.03188910238612e-06 NA NA NA hsa-miR-21-5p PITX2 2.73773305747971 1.38864982139576e-43 -2.22753708360439 1.34545225235821e-06 miRNATAP -0.41239184337053 6.22516654017053e-05 NA NA NA hsa-miR-30d-3p PITX2 0.977747550180601 4.3048212205381e-05 -2.22753708360439 1.34545225235821e-06 miRNATAP -0.29303744848187 0.00187561025673683 NA NA NA hsa-miR-320a PITX2 0.438165828017084 0.0390159073347133 -2.22753708360439 1.34545225235821e-06 miRanda -0.350775538117375 0.001045664344637 NA NA NA hsa-miR-320b PITX2 1.55692969039548 1.41071034251915e-08 -2.22753708360439 1.34545225235821e-06 miRanda -0.244644637998955 0.00254248661796217 NA NA NA hsa-miR-324-5p PITX2 2.95683728155095 1.32960514360912e-20 -2.22753708360439 1.34545225235821e-06 miRanda -0.302821506575935 6.77580657980091e-06 NA NA NA hsa-miR-342-3p PITX2 1.49115144672245 1.43879249744621e-07 -2.22753708360439 1.34545225235821e-06 miRanda -0.160015460675057 0.0425202565962167 NA NA NA hsa-miR-501-5p PITX2 1.93654809410041 1.3779381780759e-10 -2.22753708360439 1.34545225235821e-06 PITA;miRNATAP -0.197326519563281 0.00901909167088977 NA NA NA hsa-miR-590-3p PITX2 2.59289455139753 1.03200520972022e-21 -2.22753708360439 1.34545225235821e-06 miRanda -0.294374116563848 0.000298522267849705 NA NA NA hsa-miR-590-5p PITX2 3.18300989862077 2.06813568597893e-26 -2.22753708360439 1.34545225235821e-06 PITA;miRanda;miRNATAP -0.350410152006315 1.21775936912562e-06 NA NA NA hsa-miR-183-5p PPP2CB 4.19757025992371 4.79612296318304e-26 -0.783679156108793 2.67817932533534e-08 MirTarget;miRNATAP -0.115935862473986 2.8039910681077e-13 NA NA NA hsa-miR-32-3p PPP2CB 2.02436999565685 5.94091197945307e-09 -0.783679156108793 2.67817932533534e-08 MirTarget -0.105750464768045 1.64351977471817e-06 NA NA NA hsa-miR-361-5p PPP2CB 0.971859117235239 5.30236555707088e-09 -0.783679156108793 2.67817932533534e-08 miRanda -0.206656922572491 4.60021445788998e-07 NA NA NA hsa-miR-425-5p PPP2CB 3.07071373939774 4.02947460586085e-25 -0.783679156108793 2.67817932533534e-08 miRNAWalker2_validate -0.185494581813071 1.46832581012673e-18 NA NA NA hsa-miR-199b-5p RBL1 0.218704279044827 0.519493319158441 1.07061654035036 4.84800665443549e-05 miRanda -0.114364377483128 0.00253555908216694 NA NA NA hsa-miR-140-5p RBL2 0.844753502512594 3.73722278438606e-05 -0.598910927791217 0.000318998334086003 miRanda -0.11867323020571 0.00262978059184829 NA NA NA hsa-miR-142-5p RBL2 1.17581605694506 0.0018174701991234 -0.598910927791217 0.000318998334086003 PITA -0.103739178866545 9.11193439074471e-07 NA NA NA hsa-miR-576-5p RBL2 2.20467023993664 3.4053475193793e-19 -0.598910927791217 0.000318998334086003 MirTarget;PITA -0.126790145697504 5.30686012438181e-05 NA NA NA hsa-miR-361-5p RHOA 0.971859117235239 5.30236555707088e-09 -0.230748867704724 0.030592243709878 MirTarget;PITA;miRanda -0.164727125115389 5.91440692337907e-08 NA NA NA hsa-let-7a-3p ROCK1 1.42015538786275 7.03375209382654e-13 -1.02661670614902 1.94754524728051e-09 MirTarget -0.16003331936042 0.000120540876738803 NA NA NA hsa-let-7g-3p ROCK1 3.26398061402445 3.96263126107645e-25 -1.02661670614902 1.94754524728051e-09 MirTarget -0.15581302459487 8.95130786544619e-10 NA NA NA hsa-miR-107 ROCK1 1.30977326593435 1.30372468603965e-11 -1.02661670614902 1.94754524728051e-09 miRanda -0.119087364388625 0.00550312830212256 NA NA NA hsa-miR-126-5p ROCK1 0.895338176458417 2.33372756450713e-05 -1.02661670614902 1.94754524728051e-09 mirMAP -0.172464120027516 1.27104399703317e-05 27108693 MicroRNA 126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma metastasis kidney renal cell cancer hsa-miR-148b-3p ROCK1 1.97815018171325 6.07715327281595e-26 -1.02661670614902 1.94754524728051e-09 miRNAWalker2_validate -0.279081182346667 2.14015194986577e-11 NA NA NA hsa-miR-16-1-3p ROCK1 2.56983217111073 3.02262181237943e-20 -1.02661670614902 1.94754524728051e-09 MirTarget -0.207917435482076 6.59320429139509e-13 NA NA NA hsa-miR-182-5p ROCK1 3.53923166221814 5.07781258121574e-21 -1.02661670614902 1.94754524728051e-09 MirTarget -0.129367164013929 6.18056517206253e-10 NA NA NA hsa-miR-190a-5p ROCK1 0.762748400660219 0.0035950590410453 -1.02661670614902 1.94754524728051e-09 MirTarget -0.112852694205429 0.000456951035558202 NA NA NA hsa-miR-196b-5p ROCK1 1.71646270856386 4.37735885910369e-09 -1.02661670614902 1.94754524728051e-09 MirTarget -0.105631135385179 0.000182173962330639 NA NA NA hsa-miR-199b-5p ROCK1 0.218704279044827 0.519493319158441 -1.02661670614902 1.94754524728051e-09 miRanda -0.105786266749066 1.83517740907298e-05 NA NA NA hsa-miR-320a ROCK1 0.438165828017084 0.0390159073347133 -1.02661670614902 1.94754524728051e-09 miRanda -0.23831134413994 1.32756646387868e-09 NA NA NA hsa-miR-320b ROCK1 1.55692969039548 1.41071034251915e-08 -1.02661670614902 1.94754524728051e-09 miRanda -0.159130778995994 1.01124713873982e-07 NA NA NA hsa-miR-324-5p ROCK1 2.95683728155095 1.32960514360912e-20 -1.02661670614902 1.94754524728051e-09 MirTarget;PITA;miRanda -0.118431313766168 2.2910613914641e-06 NA NA NA hsa-miR-582-5p ROCK1 0.609226359812689 0.032988717891497 -1.02661670614902 1.94754524728051e-09 PITA -0.11645225372736 7.38340442690333e-05 NA NA NA hsa-miR-664a-3p ROCK1 0.634721925861133 0.00520070178640421 -1.02661670614902 1.94754524728051e-09 mirMAP -0.244809843386458 1.76957821323578e-11 NA NA NA hsa-let-7a-3p ROCK2 1.42015538786275 7.03375209382654e-13 -1.27631616742797 8.42580604068128e-07 mirMAP -0.210808918216694 0.000797703640371582 NA NA NA hsa-miR-126-5p ROCK2 0.895338176458417 2.33372756450713e-05 -1.27631616742797 8.42580604068128e-07 mirMAP -0.189029821054627 0.00159176807510824 NA NA NA hsa-miR-127-5p ROCK2 1.19850695520181 4.10976607177645e-05 -1.27631616742797 8.42580604068128e-07 PITA -0.147350589855343 0.000623699318629899 NA NA NA hsa-miR-142-3p ROCK2 2.75247908790621 1.45636065474764e-12 -1.27631616742797 8.42580604068128e-07 PITA;miRanda;miRNATAP -0.106911050458868 0.000733555550863697 NA NA NA hsa-miR-17-5p ROCK2 3.2710598467455 9.93128340539455e-27 -1.27631616742797 8.42580604068128e-07 TargetScan -0.215326836171022 2.16038147723404e-08 NA NA NA hsa-miR-3607-3p ROCK2 2.68532138541128 5.66716351955047e-14 -1.27631616742797 8.42580604068128e-07 mirMAP -0.182162248755882 1.90545088147527e-07 NA NA NA hsa-miR-369-3p ROCK2 0.946781510019564 0.00134850306966842 -1.27631616742797 8.42580604068128e-07 PITA -0.129098178306128 0.00264599376211178 NA NA NA hsa-miR-500a-5p ROCK2 1.72110365584658 3.0807246212659e-10 -1.27631616742797 8.42580604068128e-07 mirMAP -0.154970725822778 0.000663866430657911 NA NA NA hsa-miR-539-5p ROCK2 0.95216780650456 0.00284373332122135 -1.27631616742797 8.42580604068128e-07 mirMAP -0.115978170349612 0.00365972634311164 NA NA NA hsa-miR-582-5p ROCK2 0.609226359812689 0.032988717891497 -1.27631616742797 8.42580604068128e-07 mirMAP -0.134198928299352 0.00253763920219959 NA NA NA hsa-miR-589-3p ROCK2 2.51971841868825 2.39125940264107e-11 -1.27631616742797 8.42580604068128e-07 mirMAP -0.122788727749752 0.0010074207494257 NA NA NA hsa-miR-590-3p ROCK2 2.59289455139753 1.03200520972022e-21 -1.27631616742797 8.42580604068128e-07 miRanda;mirMAP -0.185591580714152 4.79951683893355e-05 NA NA NA hsa-miR-26b-5p SMAD1 0.885393662798425 3.2116297961629e-06 -0.109343978474048 0.484396115391152 MirTarget -0.160417687044586 4.77036483505897e-05 25761878;27027434 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1;Twist1 related miR 26b 5p suppresses epithelial mesenchymal transition migration and invasion by targeting SMAD1 in hepatocellular carcinoma; Subsequent investigation revealed that miR-26b-5p directly inhibited SMAD family member 1 SMAD1 expression; miR-26b-5p repressed BMP4/Smad1 signaling following SMAD1 inhibition; Overexpression of SMAD1 reversed the function of miR-26b-5p; In human HCC tissues and mouse xenograft tumors miR-26b-5p levels were inversely correlated with SMAD1 expression as well as metastasis; miR-26b-5p suppresses Twist1-induced EMT invasion and metastasis of HCC cells by targeting SMAD1 and BMP4/Smad1 signaling ;metastasis sarcoma;liver cancer hsa-miR-30b-5p SMAD1 0.800822374912712 0.000133601914525413 -0.109343978474048 0.484396115391152 miRNAWalker2_validate;miRTarBase -0.160718917203476 6.90626781792677e-06 NA NA NA hsa-miR-30c-5p SMAD1 0.778774633108 0.000285599212429136 -0.109343978474048 0.484396115391152 miRNAWalker2_validate;miRTarBase -0.188361723191194 5.8391318593494e-08 NA NA NA hsa-miR-30d-5p SMAD1 0.675423997639582 0.00270618816039773 -0.109343978474048 0.484396115391152 miRNAWalker2_validate;miRTarBase -0.133891706488833 6.12990315600052e-05 NA NA NA hsa-miR-181a-5p SMAD2 2.29556023480783 1.8138457900616e-21 -0.217872679367038 0.049686680004959 mirMAP -0.112519930018506 7.12492899365623e-08 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 2.49307679431293 3.92829250217627e-20 -0.217872679367038 0.049686680004959 mirMAP -0.102985568847665 2.98550912982442e-08 NA NA NA hsa-miR-26a-5p SMAD2 0.0464832722967259 0.752628386912329 -0.217872679367038 0.049686680004959 mirMAP -0.11130754251612 0.0026935683249941 NA NA NA hsa-miR-361-3p SMAD2 1.07367425434318 1.73142774168958e-09 -0.217872679367038 0.049686680004959 miRNATAP -0.114638945395339 0.000110242156000821 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-let-7a-2-3p SMAD3 0.0400317820791161 0.91528727576685 -0.145068391221315 0.569239559252949 mirMAP -0.127624470471724 0.000115244641159406 NA NA NA hsa-miR-125b-2-3p SMAD3 -1.83175829351767 2.94917958974528e-05 -0.145068391221315 0.569239559252949 mirMAP -0.167358601156691 2.00437048846808e-09 NA NA NA hsa-miR-127-5p SMAD3 1.19850695520181 4.10976607177645e-05 -0.145068391221315 0.569239559252949 mirMAP -0.175774439508378 2.40422906256706e-05 NA NA NA hsa-miR-132-3p SMAD3 0.156276992635384 0.408190812100704 -0.145068391221315 0.569239559252949 mirMAP -0.307625427852275 2.61092084929535e-06 NA NA NA hsa-miR-142-5p SMAD3 1.17581605694506 0.0018174701991234 -0.145068391221315 0.569239559252949 PITA -0.121783193917905 0.000168543842540946 NA NA NA hsa-miR-145-5p SMAD3 -1.55259331973517 9.97889123247165e-07 -0.145068391221315 0.569239559252949 MirTarget;miRNATAP -0.102333497957109 0.0076425159078547 27237033 MiR 145 and miR 203 represses TGF β induced epithelial mesenchymal transition and invasion by inhibiting SMAD3 in non small cell lung cancer cells; siRNA-mediated knockdown of SMAD3 copied the phenotype of miR-145 and miR-203 overexpression in A549 and 95C cells; MiR-145 and miR-203 inhibited TGF-β-induced EMT and invasion through repression of SMAD3 in NSCLC cells lung squamous cell cancer hsa-miR-155-5p SMAD3 1.20164021433135 0.00086170622431261 -0.145068391221315 0.569239559252949 miRNAWalker2_validate -0.167586664196246 6.20173080978562e-07 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-186-5p SMAD3 1.47445398888668 3.0781726595413e-15 -0.145068391221315 0.569239559252949 mirMAP -0.133188903744895 0.0388863467309017 NA NA NA hsa-miR-188-5p SMAD3 2.52825126596644 6.78099435999778e-14 -0.145068391221315 0.569239559252949 PITA -0.184950370967834 7.35063541952032e-07 NA NA NA hsa-miR-18a-5p SMAD3 3.78535678765353 3.72446596213886e-26 -0.145068391221315 0.569239559252949 miRNAWalker2_validate -0.136878014915373 5.63544047470077e-05 23249750 The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling glioblastoma hsa-miR-195-5p SMAD3 -1.44753678070504 8.70594292149271e-09 -0.145068391221315 0.569239559252949 MirTarget -0.155082880098317 0.00129697117488075 27206216 MiR 195 Suppresses Cervical Cancer Migration and Invasion Through Targeting Smad3; The purposes of this study were to investigate the role of miR-195 in cervical cancer and clarify the regulation of Smad3 by miR-195; Smad3 was verified as a direct target of miR-195 which was further confirmed by the inverse expression of miR-195 and Smad3 in patients' specimens cervical and endocervical cancer hsa-miR-212-3p SMAD3 0.357878936470387 0.232446214501331 -0.145068391221315 0.569239559252949 mirMAP -0.196270501722139 1.760966299711e-06 NA NA NA hsa-miR-326 SMAD3 0.715313016136042 0.0610265683213359 -0.145068391221315 0.569239559252949 miRanda -0.127854658986735 7.18944162313972e-05 NA NA NA hsa-miR-424-5p SMAD3 1.61930224569578 1.89642549274994e-10 -0.145068391221315 0.569239559252949 MirTarget -0.137637867799144 0.0037931514509118 27655675 miR 424 5p promotes proliferation of gastric cancer by targeting Smad3 through TGF β signaling pathway; QRT-PCR was used to determine the expression levels of miR-424-5p and Smad3; Luciferase reporter assay and western blotting were used to prove that Smad3 was one of the direct targets of miR-424-5p; In addition luciferase reporter assay and western blotting assay revealed that Smad3 was a direct target of miR-424-5p; Over-expression of Smad3 could partially reverse the effects of miR-424-5p on GC cell proliferation; Our study further revealed that miR-424-5p could inhibit TGF-β signaling pathway by Smad3 gastric cancer hsa-miR-485-3p SMAD3 0.442820096243914 0.166634696770945 -0.145068391221315 0.569239559252949 MirTarget -0.146973333951251 0.000145374061338494 NA NA NA hsa-miR-495-3p SMAD3 -0.0847115949846082 0.763475496144456 -0.145068391221315 0.569239559252949 mirMAP -0.147079833458788 0.000814867470605654 NA NA NA hsa-miR-497-5p SMAD3 0.0257087130056286 0.918145413833358 -0.145068391221315 0.569239559252949 MirTarget -0.149416186909323 0.00253073754447704 NA NA NA hsa-miR-501-5p SMAD3 1.93654809410041 1.3779381780759e-10 -0.145068391221315 0.569239559252949 mirMAP -0.178593095060563 1.2547872342843e-05 NA NA NA hsa-miR-589-3p SMAD3 2.51971841868825 2.39125940264107e-11 -0.145068391221315 0.569239559252949 mirMAP -0.112359264624293 0.0019298395243008 NA NA NA hsa-let-7f-1-3p SMAD4 1.55054488387679 7.31326775537952e-11 -0.586921155134023 3.52416916552263e-06 mirMAP -0.106405479232356 4.39371133743738e-05 NA NA NA hsa-miR-140-5p SMAD4 0.844753502512594 3.73722278438606e-05 -0.586921155134023 3.52416916552263e-06 miRanda -0.114517150132142 0.000134319769998401 NA NA NA hsa-miR-146b-5p SMAD4 1.75587235896724 1.15724631266659e-07 -0.586921155134023 3.52416916552263e-06 PITA;miRanda;miRNATAP -0.103959435086478 8.75874581151263e-09 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-186-5p SMAD4 1.47445398888668 3.0781726595413e-15 -0.586921155134023 3.52416916552263e-06 miRNAWalker2_validate;mirMAP -0.107040467643529 0.000873099593755318 NA NA NA hsa-miR-2355-5p SMAD4 1.32510310704724 8.25139516692683e-07 -0.586921155134023 3.52416916552263e-06 MirTarget -0.100237269384076 8.83439826066143e-06 NA NA NA hsa-miR-26b-5p SMAD4 0.885393662798425 3.2116297961629e-06 -0.586921155134023 3.52416916552263e-06 MirTarget;miRNATAP -0.101564603889141 0.00171580634002753 24890815 Overexpression of miR-26b also repressed Smad4 expression whereas its inhibition elevated Smad4 expression; In HCC cell lines miR-26b targeted the 3'UTR of USP9X which in turn affects EMT through Smad4 and the TGF-β signaling pathway liver cancer hsa-miR-27a-3p SMAD4 1.66542180327138 4.93775737894805e-13 -0.586921155134023 3.52416916552263e-06 MirTarget -0.13536279837513 1.62491622147447e-07 NA NA NA hsa-miR-34a-5p SMAD4 1.9016323452565 1.43092834643601e-14 -0.586921155134023 3.52416916552263e-06 miRNATAP -0.121709073519824 3.8975183335493e-07 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-362-3p SMAD4 2.0756816987665 3.89026064579331e-12 -0.586921155134023 3.52416916552263e-06 miRNATAP -0.105074125190041 3.2218791406447e-07 NA NA NA hsa-miR-576-5p SMAD4 2.20467023993664 3.4053475193793e-19 -0.586921155134023 3.52416916552263e-06 mirMAP -0.106133513564488 8.78863207489382e-06 NA NA NA hsa-miR-130a-3p SMAD5 2.02021855058359 1.26427102520415e-11 -0.471478570121366 0.00167073887561032 miRNAWalker2_validate;MirTarget;miRNATAP -0.115596844311268 9.37653814237818e-07 NA NA NA hsa-miR-155-5p SMAD5 1.20164021433135 0.00086170622431261 -0.471478570121366 0.00167073887561032 miRNAWalker2_validate;miRTarBase -0.105993087947379 8.66287104836701e-08 20133617 Targeting of SMAD5 links microRNA 155 to the TGF beta pathway and lymphomagenesis; Using unbiased genome-wide approaches in DLBCL we discovered that the oncogenic microRNA-155 miR-155 directly targets the bone morphogenetic protein BMP-responsive transcriptional factor SMAD5; In confirmatory experiments RNAi-based SMAD5 knockdown recapitulated in vitro and in vivo the effects miR-155 overexpression; Furthermore in primary DLBCLs miR-155 overexpression inhibited SMAD5 expression and disrupted its activity as defined by individual and global analyses of its transcriptional targets; Together our data helped explain miR-155 function highlighted a hitherto unappreciated role of SMAD5 in lymphoma biology and defined a unique mechanism used by cancer cells to escape TGF-beta's growth-inhibitory effects lymphoma hsa-miR-26a-2-3p SMAD5 0.823520019989974 0.00017092160823769 -0.471478570121366 0.00167073887561032 mirMAP -0.129782059782792 9.50385847277344e-05 NA NA NA hsa-miR-338-3p SMAD5 0.453166438193782 0.144583389707558 -0.471478570121366 0.00167073887561032 miRanda -0.119803004558612 2.34419386314808e-07 NA NA NA hsa-miR-362-5p SMAD5 1.59303749908759 9.582675908797e-08 -0.471478570121366 0.00167073887561032 mirMAP -0.102687926300065 1.6801420433364e-05 NA NA NA hsa-miR-576-5p SMAD5 2.20467023993664 3.4053475193793e-19 -0.471478570121366 0.00167073887561032 mirMAP -0.101858175302845 0.000313368986606011 NA NA NA hsa-miR-134-5p SMAD6 0.141163006984518 0.655334296084178 -0.41737672717596 0.262999009930425 MirTarget -0.313489061011026 2.71663210122221e-08 NA NA NA hsa-miR-340-5p SMAD6 0.30282999308409 0.157744789519131 -0.41737672717596 0.262999009930425 mirMAP -0.49488465760754 3.08467706720563e-09 NA NA NA hsa-miR-362-3p SMAD6 2.0756816987665 3.89026064579331e-12 -0.41737672717596 0.262999009930425 miRanda -0.187184810332384 0.00206138617897755 NA NA NA hsa-miR-590-3p SMAD6 2.59289455139753 1.03200520972022e-21 -0.41737672717596 0.262999009930425 miRanda -0.158425320327704 0.0152020881183699 NA NA NA hsa-miR-103a-3p SMAD7 1.44083190496858 1.53799939616416e-13 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate -0.259342276341149 1.42207366057362e-06 NA NA NA hsa-miR-106a-5p SMAD7 2.48882002962836 1.99757727374521e-12 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.125254691617488 2.22681317473832e-05 NA NA NA hsa-miR-106b-5p SMAD7 2.46782146831112 1.36171495805632e-23 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.277320790302171 9.3034900627467e-12 27619676;25286029;22286770 MiR 106b promotes migration and invasion through enhancing EMT via downregulation of Smad 7 in Kazakh's esophageal squamous cell carcinoma; To understand the regulation between miR-106b and Smad 7 qRT-PCR and western blot were performed; Smad 7 was confirmed as a downstream target of miR-106b in our experimental setting; Our results indicated that miR-106b can promote migration and invasion of ESCC cells through enhancing EMT process via downregulation of Smad 7 suggesting that miR-106b can be a potential molecular phenotype in ESCC metastases;Smad7 which inhibits transforming growth factor-β TGF-β/Smad signaling as a target of the miR-106b family was downregulated in CD44+ cells;The miR 106b 25 cluster targets Smad7 activates TGF β signaling and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer metastasis;; esophageal cancer;gastric cancer;breast cancer hsa-miR-15a-5p SMAD7 2.34669284378787 1.69544424500258e-23 -1.18986730797292 6.37278457783496e-08 MirTarget;miRNATAP -0.159261254747071 0.00025730933802413 NA NA NA hsa-miR-15b-5p SMAD7 1.57112623124278 9.14247846750597e-13 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.31270512309151 3.09745138070762e-11 NA NA NA hsa-miR-16-5p SMAD7 1.75824877145857 1.68592440033108e-16 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.268581547269042 3.03392557940829e-08 NA NA NA hsa-miR-17-5p SMAD7 3.2710598467455 9.93128340539455e-27 -1.18986730797292 6.37278457783496e-08 TargetScan;miRNATAP -0.179045141842203 4.62928621050582e-08 NA NA NA hsa-miR-182-5p SMAD7 3.53923166221814 5.07781258121574e-21 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.139835996687329 2.24704056840338e-07 NA NA NA hsa-miR-185-3p SMAD7 2.3922478518806 1.3373426768452e-14 -1.18986730797292 6.37278457783496e-08 MirTarget -0.16019453105202 1.61560898647719e-06 NA NA NA hsa-miR-200b-3p SMAD7 3.78235093249346 3.18343003239465e-14 -1.18986730797292 6.37278457783496e-08 TargetScan;mirMAP -0.111551767935926 6.99585057787961e-08 NA NA NA hsa-miR-20a-5p SMAD7 3.15577933619191 4.19753346442454e-25 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.160049327078402 1.33417399732611e-06 NA NA NA hsa-miR-20b-5p SMAD7 2.07706563022469 1.10107236083433e-05 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.110638066003306 7.64101248507177e-07 NA NA NA hsa-miR-21-3p SMAD7 2.19296355304364 4.63665722759779e-15 -1.18986730797292 6.37278457783496e-08 MirTarget -0.111091823108787 0.0029631409368765 23372687;27185036;26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways ;; breast cancer;lung squamous cell cancer;breast cancer hsa-miR-21-5p SMAD7 2.73773305747971 1.38864982139576e-43 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.100676973983357 0.0424364871556223 23372687;27185036;26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways ;; breast cancer;lung squamous cell cancer;breast cancer hsa-miR-25-3p SMAD7 1.36472605225697 4.83790725935681e-11 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.32459267218806 1.06984918886287e-10 23435373 MicroRNA 25 functions as a potential tumor suppressor in colon cancer by targeting Smad7; Furthermore bioinformatic predictions and experimental validation were used to identify Smad7 as a direct target of miR-25; Functional reverse experiments indicated that the antitumor effects of miR-25 were probably mediated by its repression of Smad7; These results suggest that miR-25 may function as a tumor suppressor by targeting Smad7 in colon cancer colon cancer hsa-miR-26b-5p SMAD7 0.885393662798425 3.2116297961629e-06 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate -0.153719560363337 0.00686506683647215 NA NA NA hsa-miR-3065-5p SMAD7 2.74629919868982 1.86846589298284e-08 -1.18986730797292 6.37278457783496e-08 mirMAP -0.189760432676296 2.54459807792449e-13 NA NA NA hsa-miR-32-5p SMAD7 2.34056473219422 6.24134585974322e-20 -1.18986730797292 6.37278457783496e-08 MirTarget;miRNATAP -0.193932841483501 1.28093315805443e-06 NA NA NA hsa-miR-324-3p SMAD7 2.08739139768981 3.11885987067952e-13 -1.18986730797292 6.37278457783496e-08 MirTarget -0.213445619719733 3.49943456935247e-09 NA NA NA hsa-miR-330-3p SMAD7 0.876747334239085 0.00073709016089703 -1.18986730797292 6.37278457783496e-08 PITA;miRNATAP -0.131059927114688 0.00158540861178329 NA NA NA hsa-miR-340-5p SMAD7 0.30282999308409 0.157744789519131 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.23974541892437 1.96057225251223e-06 NA NA NA hsa-miR-34a-5p SMAD7 1.9016323452565 1.43092834643601e-14 -1.18986730797292 6.37278457783496e-08 MirTarget -0.136694424476981 0.00127398242742499 NA NA NA hsa-miR-363-3p SMAD7 1.50575300026701 0.00020976164678918 -1.18986730797292 6.37278457783496e-08 MirTarget;miRNATAP -0.128264808705891 9.56521837005215e-07 NA NA NA hsa-miR-374b-3p SMAD7 0.930487774873495 2.74420094310516e-05 -1.18986730797292 6.37278457783496e-08 MirTarget -0.156200309599714 0.00134771152654086 NA NA NA hsa-miR-590-3p SMAD7 2.59289455139753 1.03200520972022e-21 -1.18986730797292 6.37278457783496e-08 miRanda -0.222506648161791 7.31039792477637e-09 NA NA NA hsa-miR-590-5p SMAD7 3.18300989862077 2.06813568597893e-26 -1.18986730797292 6.37278457783496e-08 MirTarget;PITA;miRanda;miRNATAP -0.210186244146202 8.48093543573176e-10 NA NA NA hsa-miR-671-5p SMAD7 2.97733652243246 1.21148452344738e-23 -1.18986730797292 6.37278457783496e-08 PITA -0.232453499061808 7.31832849987942e-11 NA NA NA hsa-miR-92a-3p SMAD7 2.06460102658973 1.44784291084757e-19 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.243515114080339 5.96198780654537e-08 NA NA NA hsa-miR-92b-3p SMAD7 1.20409245530001 3.41055816361655e-06 -1.18986730797292 6.37278457783496e-08 MirTarget;miRNATAP -0.194822895712289 2.03841347106112e-06 NA NA NA hsa-miR-93-5p SMAD7 3.03961860136032 1.11672209617395e-24 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.211234452180854 4.08827528617675e-10 25371073 Mothers against decapentaplegic homolog 7 Smad7 as an essential molecular protein for nuclear accumulation of β-catenin in the canonical Wnt signaling pathway is predicted as a putative target gene of miR-93 by the silico method and demonstrated that it may be suppressed by targeting its 3'UTR; These findings showed that miR-93 suppresses colorectal cancer development via downregulating Wnt/β-catenin at least in part by targeting Smad7 colorectal cancer hsa-miR-96-5p SMAD7 4.89433085814374 1.92000659886961e-31 -1.18986730797292 6.37278457783496e-08 TargetScan;miRNATAP -0.138733388809805 8.79404813817033e-09 NA NA NA hsa-miR-98-5p SMAD7 1.11154309866014 1.24143909012085e-08 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate -0.283857586571606 1.75254699511423e-07 NA NA NA hsa-let-7a-3p SMAD9 1.42015538786275 7.03375209382654e-13 -2.7848027081689 2.86813944167271e-09 mirMAP -0.453996332573743 7.10234407830253e-05 NA NA NA hsa-let-7b-3p SMAD9 0.868207752019623 1.30460056774366e-05 -2.7848027081689 2.86813944167271e-09 mirMAP -0.327492920252394 0.00483905140713487 NA NA NA hsa-let-7f-1-3p SMAD9 1.55054488387679 7.31326775537952e-11 -2.7848027081689 2.86813944167271e-09 mirMAP -0.556678069887955 8.98260825167881e-09 NA NA NA hsa-miR-103a-2-5p SMAD9 2.47599305985086 7.933028987326e-11 -2.7848027081689 2.86813944167271e-09 mirMAP -0.41242753802179 4.13251096827355e-10 NA NA NA hsa-miR-106b-5p SMAD9 2.46782146831112 1.36171495805632e-23 -2.7848027081689 2.86813944167271e-09 miRNAWalker2_validate;mirMAP -0.292735903742505 0.00100052637744358 NA NA NA hsa-miR-126-5p SMAD9 0.895338176458417 2.33372756450713e-05 -2.7848027081689 2.86813944167271e-09 mirMAP -0.298190793991851 0.00636389911574332 NA NA NA hsa-miR-142-5p SMAD9 1.17581605694506 0.0018174701991234 -2.7848027081689 2.86813944167271e-09 mirMAP -0.401583178649486 1.80594088598854e-11 NA NA NA hsa-miR-148b-5p SMAD9 2.18024067300781 2.84770452413262e-14 -2.7848027081689 2.86813944167271e-09 MirTarget -0.360840518187346 1.16711821233765e-05 NA NA NA hsa-miR-155-5p SMAD9 1.20164021433135 0.00086170622431261 -2.7848027081689 2.86813944167271e-09 mirMAP -0.430064243927496 5.32747308823898e-12 NA NA NA hsa-miR-16-2-3p SMAD9 2.31623086727196 4.29838149388188e-20 -2.7848027081689 2.86813944167271e-09 mirMAP -0.613308841376567 7.93017543818331e-13 NA NA NA hsa-miR-17-5p SMAD9 3.2710598467455 9.93128340539455e-27 -2.7848027081689 2.86813944167271e-09 mirMAP -0.418936062860021 2.07578044592756e-09 NA NA NA hsa-miR-181a-2-3p SMAD9 2.19062681262366 3.81790102612782e-13 -2.7848027081689 2.86813944167271e-09 MirTarget -0.209504740511286 0.00498900983646523 NA NA NA hsa-miR-186-5p SMAD9 1.47445398888668 3.0781726595413e-15 -2.7848027081689 2.86813944167271e-09 mirMAP -0.584591834022809 1.067366223163e-06 NA NA NA hsa-miR-193a-5p SMAD9 0.562511612963676 0.0239254699649222 -2.7848027081689 2.86813944167271e-09 MirTarget;TargetScan;miRNATAP -0.357381025024296 0.000118027844911521 NA NA NA hsa-miR-20a-5p SMAD9 3.15577933619191 4.19753346442454e-25 -2.7848027081689 2.86813944167271e-09 mirMAP -0.417430567129802 3.06001415541931e-09 NA NA NA hsa-miR-2355-5p SMAD9 1.32510310704724 8.25139516692683e-07 -2.7848027081689 2.86813944167271e-09 MirTarget -0.418131540732281 7.35086031488129e-07 NA NA NA hsa-miR-23a-3p SMAD9 1.00493340843378 2.55313889288924e-08 -2.7848027081689 2.86813944167271e-09 mirMAP -0.742139863003304 3.64406324925616e-09 NA NA NA hsa-miR-26a-2-3p SMAD9 0.823520019989974 0.00017092160823769 -2.7848027081689 2.86813944167271e-09 mirMAP -0.486046601254785 4.09181811510427e-06 NA NA NA hsa-miR-27a-3p SMAD9 1.66542180327138 4.93775737894805e-13 -2.7848027081689 2.86813944167271e-09 MirTarget;miRNATAP -0.805407277073536 1.55712608121549e-17 NA NA NA hsa-miR-29a-5p SMAD9 1.46749674755271 3.34605004270294e-07 -2.7848027081689 2.86813944167271e-09 MirTarget -0.711192652087268 1.35776994309128e-18 NA NA NA hsa-miR-3065-5p SMAD9 2.74629919868982 1.86846589298284e-08 -2.7848027081689 2.86813944167271e-09 mirMAP -0.272953580569046 1.37923135274858e-06 NA NA NA hsa-miR-320b SMAD9 1.55692969039548 1.41071034251915e-08 -2.7848027081689 2.86813944167271e-09 MirTarget;miRanda -0.170079894324331 0.041127877039705 NA NA NA hsa-miR-335-3p SMAD9 3.08791651139852 5.31309869723517e-12 -2.7848027081689 2.86813944167271e-09 mirMAP -0.106360080345522 0.0346729699173305 NA NA NA hsa-miR-3607-3p SMAD9 2.68532138541128 5.66716351955047e-14 -2.7848027081689 2.86813944167271e-09 MirTarget;mirMAP -0.298629742155556 3.01785967223407e-06 NA NA NA hsa-miR-382-5p SMAD9 0.545586518720593 0.0621058523772996 -2.7848027081689 2.86813944167271e-09 mirMAP -0.157447043795536 0.0474616738231658 NA NA NA hsa-miR-424-3p SMAD9 0.991234037658669 0.000358786932730602 -2.7848027081689 2.86813944167271e-09 mirMAP -0.20181612581059 0.0155941408003313 NA NA NA hsa-miR-452-3p SMAD9 2.42521958420768 4.08754552781156e-07 -2.7848027081689 2.86813944167271e-09 MirTarget -0.22552498408445 1.94179210685325e-06 NA NA NA hsa-miR-455-5p SMAD9 2.2582442061694 1.43472128037398e-13 -2.7848027081689 2.86813944167271e-09 MirTarget -0.548906990875791 1.52920365233191e-14 NA NA NA hsa-miR-590-3p SMAD9 2.59289455139753 1.03200520972022e-21 -2.7848027081689 2.86813944167271e-09 mirMAP -0.493952558719017 1.92383174003233e-09 NA NA NA hsa-miR-625-3p SMAD9 1.18769734290812 2.47200238827911e-06 -2.7848027081689 2.86813944167271e-09 mirMAP -0.274869937292521 0.00253970004732871 NA NA NA hsa-miR-629-3p SMAD9 2.36570947321815 1.33458201201618e-11 -2.7848027081689 2.86813944167271e-09 MirTarget -0.459528831281706 1.39306318818534e-10 NA NA NA hsa-miR-93-5p SMAD9 3.03961860136032 1.11672209617395e-24 -2.7848027081689 2.86813944167271e-09 mirMAP -0.313849371675716 1.83576290394267e-05 NA NA NA hsa-miR-944 SMAD9 2.91186649218281 1.31574753528144e-06 -2.7848027081689 2.86813944167271e-09 mirMAP -0.204423898565116 1.24702621120463e-07 NA NA NA hsa-miR-28-5p SMURF2 0.230152919654905 0.0742909586754846 0.199209551479447 0.178208231024668 PITA;miRanda -0.127080382084809 0.0263023942977529 NA NA NA hsa-miR-140-3p SP1 0.0608890720479334 0.727716871248724 0.0546549076223428 0.642595666005026 PITA -0.136114654060701 3.16296214499617e-05 NA NA NA hsa-miR-199a-3p SP1 0.640600337515787 0.0380326905134914 0.0546549076223428 0.642595666005026 PITA -0.131446223931935 1.73704487679576e-13 NA NA NA hsa-miR-199a-5p SP1 0.592984035153911 0.0674836634175293 0.0546549076223428 0.642595666005026 PITA;miRanda -0.117673424048693 5.18716243557762e-12 NA NA NA hsa-miR-199b-3p SP1 0.643923492750702 0.0371742251925406 0.0546549076223428 0.642595666005026 PITA -0.131149464237985 1.90279584947662e-13 NA NA NA hsa-miR-199b-5p SP1 0.218704279044827 0.519493319158441 0.0546549076223428 0.642595666005026 PITA;miRanda -0.103705954256464 2.43386359868455e-10 NA NA NA hsa-miR-299-5p SP1 -0.274550626427337 0.386834031856446 0.0546549076223428 0.642595666005026 PITA -0.104621966732403 3.11667077183102e-09 NA NA NA hsa-miR-29a-5p SP1 1.46749674755271 3.34605004270294e-07 0.0546549076223428 0.642595666005026 mirMAP -0.112124746716959 3.37286195600269e-08 NA NA NA hsa-miR-381-3p SP1 -0.0821432056113931 0.752465205603634 0.0546549076223428 0.642595666005026 mirMAP -0.115683511108685 8.28038397117161e-08 NA NA NA hsa-miR-485-3p SP1 0.442820096243914 0.166634696770945 0.0546549076223428 0.642595666005026 PITA -0.111946195748619 1.62837145817068e-10 NA NA NA hsa-miR-28-5p TFDP1 0.230152919654905 0.0742909586754846 0.846227916601966 2.69648378919315e-07 miRanda -0.177316566489884 0.00596177796758454 NA NA NA hsa-miR-30c-5p TFDP1 0.778774633108 0.000285599212429136 0.846227916601966 2.69648378919315e-07 MirTarget;miRNATAP -0.109466733444829 0.00357936011476302 NA NA NA hsa-miR-30e-3p TFDP1 -0.215663037684509 0.235375122783546 0.846227916601966 2.69648378919315e-07 MirTarget -0.108493074044416 0.0159132450184169 NA NA NA hsa-miR-744-5p TGFB1 1.48254348878737 3.23019501613577e-09 -0.000200257511168367 0.999409206375481 miRNAWalker2_validate;miRNATAP -0.229419410482444 6.9384219754003e-06 NA NA NA hsa-miR-107 TGFB2 1.30977326593435 1.30372468603965e-11 -1.19931727990522 0.00330886829654418 miRanda -0.51939474457829 1.98547903259176e-07 NA NA NA hsa-miR-126-5p TGFB2 0.895338176458417 2.33372756450713e-05 -1.19931727990522 0.00330886829654418 mirMAP -0.25743093726133 0.00599073764101041 NA NA NA hsa-miR-130b-3p TGFB2 3.5350292994509 1.73934183852569e-27 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.344962470893237 7.65363506175553e-10 NA NA NA hsa-miR-141-3p TGFB2 5.02396127982626 2.19224509139725e-24 -1.19931727990522 0.00330886829654418 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.360699351018386 8.70106540908034e-24 NA NA NA hsa-miR-148a-3p TGFB2 1.26728238710376 2.52325607402829e-06 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.286009485859132 8.40361643900754e-05 NA NA NA hsa-miR-148b-3p TGFB2 1.97815018171325 6.07715327281595e-26 -1.19931727990522 0.00330886829654418 MirTarget -0.76533615341931 3.3613707731401e-15 NA NA NA hsa-miR-149-5p TGFB2 2.94200492826326 4.93436498919036e-14 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.268302009449797 3.19540597089803e-08 NA NA NA hsa-miR-186-5p TGFB2 1.47445398888668 3.0781726595413e-15 -1.19931727990522 0.00330886829654418 mirMAP -0.621355169758057 1.07645506474653e-09 NA NA NA hsa-miR-200a-3p TGFB2 4.59434485520731 6.38952518573476e-18 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.349625252947739 2.44117272738656e-25 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 3.12352008343999 9.49391438647189e-07 -1.19931727990522 0.00330886829654418 MirTarget -0.137892151335788 5.76268091391752e-06 NA NA NA hsa-miR-29b-3p TGFB2 1.65828197923813 1.02676780888141e-09 -1.19931727990522 0.00330886829654418 miRTarBase;MirTarget;miRNATAP -0.231729413265765 0.0012231669483933 NA NA NA hsa-miR-29c-3p TGFB2 -0.00968972577705429 0.97099586346872 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.531424404132598 2.96641887384219e-13 NA NA NA hsa-miR-301a-3p TGFB2 2.81024345929638 2.29784847962242e-17 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.322704555190408 7.77034372961379e-08 NA NA NA hsa-miR-32-3p TGFB2 2.02436999565685 5.94091197945307e-09 -1.19931727990522 0.00330886829654418 mirMAP -0.27315114570865 1.69846948907938e-05 NA NA NA hsa-miR-320a TGFB2 0.438165828017084 0.0390159073347133 -1.19931727990522 0.00330886829654418 miRanda -0.39585907442477 2.33018021074793e-05 NA NA NA hsa-miR-320b TGFB2 1.55692969039548 1.41071034251915e-08 -1.19931727990522 0.00330886829654418 miRanda -0.298228917269413 2.53643349382992e-05 NA NA NA hsa-miR-324-5p TGFB2 2.95683728155095 1.32960514360912e-20 -1.19931727990522 0.00330886829654418 miRanda -0.302705023736643 2.71602770897574e-07 NA NA NA hsa-miR-330-3p TGFB2 0.876747334239085 0.00073709016089703 -1.19931727990522 0.00330886829654418 miRNATAP -0.457254743325048 1.06037579343258e-09 NA NA NA hsa-miR-330-5p TGFB2 1.15100069700871 4.85551805046014e-07 -1.19931727990522 0.00330886829654418 miRanda -0.360450971736555 2.54978879561545e-05 NA NA NA hsa-miR-331-5p TGFB2 2.17414714166315 1.54547681391888e-18 -1.19931727990522 0.00330886829654418 miRNATAP -0.239937976385475 0.00244538329219784 NA NA NA hsa-miR-335-3p TGFB2 3.08791651139852 5.31309869723517e-12 -1.19931727990522 0.00330886829654418 mirMAP -0.22185528629857 1.89547879442152e-07 NA NA NA hsa-miR-335-5p TGFB2 1.77247705492746 2.22457658872091e-06 -1.19931727990522 0.00330886829654418 miRNAWalker2_validate -0.252111592909568 1.14412319370904e-06 NA NA NA hsa-miR-33a-3p TGFB2 1.72765312072219 1.51784443453521e-07 -1.19931727990522 0.00330886829654418 MirTarget;mirMAP -0.371056624502634 8.36332661191753e-09 NA NA NA hsa-miR-361-5p TGFB2 0.971859117235239 5.30236555707088e-09 -1.19931727990522 0.00330886829654418 miRNATAP -0.810004741713957 2.97484706931026e-12 NA NA NA hsa-miR-362-3p TGFB2 2.0756816987665 3.89026064579331e-12 -1.19931727990522 0.00330886829654418 miRanda -0.218398256631292 0.00107142313440827 NA NA NA hsa-miR-362-5p TGFB2 1.59303749908759 9.582675908797e-08 -1.19931727990522 0.00330886829654418 MirTarget -0.222085312260446 0.000683040393757458 NA NA NA hsa-miR-374a-5p TGFB2 0.484615721953736 0.0042981729815149 -1.19931727990522 0.00330886829654418 mirMAP -0.292264596541037 0.0136347038708632 NA NA NA hsa-miR-429 TGFB2 4.48815175680773 2.44117492218206e-17 -1.19931727990522 0.00330886829654418 miRNATAP -0.354478665199625 1.01610694076904e-25 NA NA NA hsa-miR-454-3p TGFB2 2.47234127820054 1.12878018736016e-21 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.36249217687122 1.13442108861214e-06 NA NA NA hsa-miR-500a-5p TGFB2 1.72110365584658 3.0807246212659e-10 -1.19931727990522 0.00330886829654418 mirMAP -0.230492171637341 0.0012015489418391 NA NA NA hsa-miR-500b-5p TGFB2 1.72172606292185 3.06592098153205e-10 -1.19931727990522 0.00330886829654418 MirTarget -0.231076703558946 0.00116359223151538 NA NA NA hsa-miR-589-3p TGFB2 2.51971841868825 2.39125940264107e-11 -1.19931727990522 0.00330886829654418 MirTarget -0.125134916260589 0.0325888808995323 NA NA NA hsa-miR-590-3p TGFB2 2.59289455139753 1.03200520972022e-21 -1.19931727990522 0.00330886829654418 mirMAP -0.266142801996328 0.000194961333085026 NA NA NA hsa-miR-590-5p TGFB2 3.18300989862077 2.06813568597893e-26 -1.19931727990522 0.00330886829654418 miRanda;miRNATAP -0.324271064441974 3.01832441227307e-07 NA NA NA hsa-miR-944 TGFB2 2.91186649218281 1.31574753528144e-06 -1.19931727990522 0.00330886829654418 mirMAP -0.180206577855112 5.25792273122866e-08 NA NA NA hsa-let-7a-3p TGFB3 1.42015538786275 7.03375209382654e-13 -1.92191802151593 4.13522948700016e-07 MirTarget -0.381916955776687 3.24138794334629e-05 NA NA NA hsa-let-7b-3p TGFB3 0.868207752019623 1.30460056774366e-05 -1.92191802151593 4.13522948700016e-07 MirTarget -0.184070571236903 0.0496762662214341 NA NA NA hsa-miR-10a-5p TGFB3 1.15016989191194 0.00372037233992369 -1.92191802151593 4.13522948700016e-07 miRNAWalker2_validate -0.418366510356312 7.09740564892359e-21 NA NA NA hsa-miR-151a-5p TGFB3 2.32422038747303 2.66226949101065e-18 -1.92191802151593 4.13522948700016e-07 MirTarget -0.825941146129225 4.42377138616228e-42 NA NA NA hsa-miR-26b-3p TGFB3 2.18464160365372 2.11543189388328e-18 -1.92191802151593 4.13522948700016e-07 MirTarget -0.677656521133706 2.42952260248002e-23 NA NA NA hsa-miR-29b-3p TGFB3 1.65828197923813 1.02676780888141e-09 -1.92191802151593 4.13522948700016e-07 miRTarBase -0.399950302957701 1.59835018316921e-09 NA NA NA hsa-miR-450b-5p TGFB3 1.69244418548325 1.68064054148881e-10 -1.92191802151593 4.13522948700016e-07 MirTarget -0.172400886618578 0.0125386808405788 NA NA NA hsa-miR-590-3p TGFB3 2.59289455139753 1.03200520972022e-21 -1.92191802151593 4.13522948700016e-07 miRanda -0.525346026949253 7.10585127062809e-16 NA NA NA hsa-miR-629-3p TGFB3 2.36570947321815 1.33458201201618e-11 -1.92191802151593 4.13522948700016e-07 MirTarget -0.297411694512799 3.147434114319e-07 NA NA NA hsa-let-7a-5p TGFBR1 0.618599506841644 2.76973453058748e-05 -0.531745632851025 0.0111481565689226 TargetScan;miRNATAP -0.244428925468535 0.000440383623292106 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC colorectal cancer hsa-let-7b-5p TGFBR1 0.604314269683977 0.00140009936153214 -0.531745632851025 0.0111481565689226 miRNATAP -0.164395211205111 0.002334077702266 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC; In luciferase assays the risk-associated allele for rs868 was associated with half the luciferase expression in the presence of miRNA let-7b-5p compared with protective allele suggesting more binding of let-7b-5p and less TGFBR1 expression colorectal cancer hsa-let-7d-5p TGFBR1 1.33236798905207 1.1741085658466e-13 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRNATAP -0.249677273322744 5.91436156062502e-06 NA NA NA hsa-let-7e-5p TGFBR1 0.860104282510173 6.04758298373779e-05 -0.531745632851025 0.0111481565689226 miRNATAP -0.165779353656999 0.000445651685953496 NA NA NA hsa-let-7f-5p TGFBR1 0.495648727272215 0.00355972741198794 -0.531745632851025 0.0111481565689226 miRNATAP -0.212539435969951 0.000421071580866339 NA NA NA hsa-let-7g-5p TGFBR1 1.20061455355116 1.50237505511483e-12 -0.531745632851025 0.0111481565689226 miRNATAP -0.498242721643013 1.58222259474873e-18 NA NA NA hsa-miR-101-3p TGFBR1 0.522819989585461 0.00375627731618038 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRNATAP -0.356084641759078 1.678272043475e-10 NA NA NA hsa-miR-126-5p TGFBR1 0.895338176458417 2.33372756450713e-05 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.153123735128566 0.00137633400200009 NA NA NA hsa-miR-128-3p TGFBR1 1.63756041666078 6.79626586407187e-14 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRTarBase -0.248098643403413 2.90608464652714e-08 NA NA NA hsa-miR-130b-3p TGFBR1 3.5350292994509 1.73934183852569e-27 -0.531745632851025 0.0111481565689226 miRNATAP -0.134668437053487 3.34039315804437e-06 NA NA NA hsa-miR-16-2-3p TGFBR1 2.31623086727196 4.29838149388188e-20 -0.531745632851025 0.0111481565689226 mirMAP -0.118014665876922 0.00216991899384218 NA NA NA hsa-miR-181c-5p TGFBR1 1.58587920618301 1.57506918816933e-10 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.16918051477343 2.32913877572708e-05 NA NA NA hsa-miR-186-5p TGFBR1 1.47445398888668 3.0781726595413e-15 -0.531745632851025 0.0111481565689226 mirMAP -0.261901522962087 6.15270096138054e-07 NA NA NA hsa-miR-200b-3p TGFBR1 3.78235093249346 3.18343003239465e-14 -0.531745632851025 0.0111481565689226 mirMAP -0.185163040320424 3.55754064059769e-23 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-2110 TGFBR1 1.16625590651194 6.4784195289885e-05 -0.531745632851025 0.0111481565689226 miRNATAP -0.203122265430452 3.02839928126399e-08 NA NA NA hsa-miR-301a-3p TGFBR1 2.81024345929638 2.29784847962242e-17 -0.531745632851025 0.0111481565689226 miRNATAP -0.188558650494062 6.94428278524489e-10 NA NA NA hsa-miR-32-3p TGFBR1 2.02436999565685 5.94091197945307e-09 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.116207615183923 0.000365699800115398 NA NA NA hsa-miR-3200-3p TGFBR1 2.70510522077868 1.90469509928484e-08 -0.531745632851025 0.0111481565689226 miRNATAP -0.120700105473579 2.69621919466987e-08 NA NA NA hsa-miR-320a TGFBR1 0.438165828017084 0.0390159073347133 -0.531745632851025 0.0111481565689226 PITA;miRanda;miRNATAP -0.326176915517583 4.1064210958607e-12 NA NA NA hsa-miR-320b TGFBR1 1.55692969039548 1.41071034251915e-08 -0.531745632851025 0.0111481565689226 PITA;miRanda;miRNATAP -0.191128801910238 1.11537638054288e-07 NA NA NA hsa-miR-330-3p TGFBR1 0.876747334239085 0.00073709016089703 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.231238826647919 1.69019842696319e-09 NA NA NA hsa-miR-331-3p TGFBR1 2.28379581858927 1.99663919173155e-18 -0.531745632851025 0.0111481565689226 PITA;miRNATAP -0.227588969955072 5.92157067223612e-10 NA NA NA hsa-miR-361-5p TGFBR1 0.971859117235239 5.30236555707088e-09 -0.531745632851025 0.0111481565689226 miRanda;mirMAP;miRNATAP -0.327512599032841 4.9385335452745e-08 NA NA NA hsa-miR-374a-5p TGFBR1 0.484615721953736 0.0042981729815149 -0.531745632851025 0.0111481565689226 mirMAP -0.1725550403971 0.00437986725180039 NA NA NA hsa-miR-429 TGFBR1 4.48815175680773 2.44117492218206e-17 -0.531745632851025 0.0111481565689226 miRanda;miRNATAP -0.169764852224625 2.30995613689702e-22 NA NA NA hsa-miR-454-3p TGFBR1 2.47234127820054 1.12878018736016e-21 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.205677505304361 6.16209314820036e-08 NA NA NA hsa-miR-500a-5p TGFBR1 1.72110365584658 3.0807246212659e-10 -0.531745632851025 0.0111481565689226 mirMAP -0.111391945877042 0.0022402772038843 NA NA NA hsa-miR-576-5p TGFBR1 2.20467023993664 3.4053475193793e-19 -0.531745632851025 0.0111481565689226 mirMAP -0.201284779052 2.74992936654638e-07 NA NA NA hsa-miR-589-3p TGFBR1 2.51971841868825 2.39125940264107e-11 -0.531745632851025 0.0111481565689226 mirMAP -0.104859492543737 0.000438540974273448 NA NA NA hsa-miR-590-3p TGFBR1 2.59289455139753 1.03200520972022e-21 -0.531745632851025 0.0111481565689226 PITA;miRanda;mirMAP;miRNATAP -0.139228339501584 0.000139021577037225 NA NA NA hsa-miR-590-5p TGFBR1 3.18300989862077 2.06813568597893e-26 -0.531745632851025 0.0111481565689226 PITA;miRanda -0.158386241001983 1.04882834086946e-06 NA NA NA hsa-miR-664a-3p TGFBR1 0.634721925861133 0.00520070178640421 -0.531745632851025 0.0111481565689226 mirMAP -0.321621318973717 1.70943055444078e-13 NA NA NA hsa-miR-769-5p TGFBR1 1.82023760596845 9.6815886564134e-14 -0.531745632851025 0.0111481565689226 PITA;miRNATAP -0.228524293799953 9.85398652877069e-09 NA NA NA hsa-miR-944 TGFBR1 2.91186649218281 1.31574753528144e-06 -0.531745632851025 0.0111481565689226 PITA;mirMAP -0.104949150832685 4.75355134217921e-10 NA NA NA hsa-miR-96-5p TGFBR1 4.89433085814374 1.92000659886961e-31 -0.531745632851025 0.0111481565689226 TargetScan;miRNATAP -0.138876787398621 7.90055950171446e-10 NA NA NA hsa-miR-98-5p TGFBR1 1.11154309866014 1.24143909012085e-08 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate -0.401926180925558 8.43130029155261e-16 NA NA NA hsa-miR-106a-5p TGFBR2 2.48882002962836 1.99757727374521e-12 -1.5612933795263 2.09571393414153e-11 miRTarBase;miRNATAP -0.174237668172683 2.7024970040951e-08 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 2.46782146831112 1.36171495805632e-23 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.446340567749987 1.4640429348369e-26 NA NA NA hsa-miR-107 TGFBR2 1.30977326593435 1.30372468603965e-11 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.33082940368913 1.15759545655126e-08 NA NA NA hsa-miR-130a-3p TGFBR2 2.02021855058359 1.26427102520415e-11 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.187222356261558 5.74404160623046e-07 NA NA NA hsa-miR-130b-3p TGFBR2 3.5350292994509 1.73934183852569e-27 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.279678154840768 1.9762101701233e-18 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 3.2710598467455 9.93128340539455e-27 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.302277707820119 6.79145607037112e-19 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-186-5p TGFBR2 1.47445398888668 3.0781726595413e-15 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.383453901935314 9.23917606419292e-11 NA NA NA hsa-miR-18a-5p TGFBR2 3.78535678765353 3.72446596213886e-26 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.25381972833671 2.41323249210829e-16 NA NA NA hsa-miR-19a-3p TGFBR2 3.42309334186656 3.02671914353412e-28 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.277232207383645 1.48488496649533e-16 NA NA NA hsa-miR-19b-3p TGFBR2 2.49529833021187 1.57028265846699e-23 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.351923320676886 1.03809079896527e-16 NA NA NA hsa-miR-20a-5p TGFBR2 3.15577933619191 4.19753346442454e-25 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.29433840605417 1.11976352607645e-17 NA NA NA hsa-miR-20b-5p TGFBR2 2.07706563022469 1.10107236083433e-05 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.105991731825053 9.98951097559816e-06 NA NA NA hsa-miR-21-5p TGFBR2 2.73773305747971 1.38864982139576e-43 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.1959869038848 0.000202473977886908 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-23a-3p TGFBR2 1.00493340843378 2.55313889288924e-08 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.150743460056457 0.0183024849464915 NA NA NA hsa-miR-29b-2-5p TGFBR2 0.910668640983475 0.00666655585493488 -1.5612933795263 2.09571393414153e-11 mirMAP -0.106614907621936 0.00190433915326164 NA NA NA hsa-miR-301a-3p TGFBR2 2.81024345929638 2.29784847962242e-17 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.303245579782603 4.36341401740489e-19 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-320a TGFBR2 0.438165828017084 0.0390159073347133 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.147256255771787 0.0072521693939925 NA NA NA hsa-miR-320b TGFBR2 1.55692969039548 1.41071034251915e-08 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.259785049714809 1.72104577406335e-10 NA NA NA hsa-miR-335-3p TGFBR2 3.08791651139852 5.31309869723517e-12 -1.5612933795263 2.09571393414153e-11 mirMAP -0.116451466105744 2.86501897855708e-06 NA NA NA hsa-miR-335-5p TGFBR2 1.77247705492746 2.22457658872091e-06 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.108328975461909 0.000362366652132911 NA NA NA hsa-miR-33a-3p TGFBR2 1.72765312072219 1.51784443453521e-07 -1.5612933795263 2.09571393414153e-11 mirMAP -0.218324746449326 5.80693592871469e-09 NA NA NA hsa-miR-429 TGFBR2 4.48815175680773 2.44117492218206e-17 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.182453703283022 7.13137317316041e-20 NA NA NA hsa-miR-454-3p TGFBR2 2.47234127820054 1.12878018736016e-21 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.334757039971147 2.96928366293251e-15 NA NA NA hsa-miR-501-3p TGFBR2 1.83132758513743 1.10971547702065e-10 -1.5612933795263 2.09571393414153e-11 TargetScan -0.239042838968307 1.06476001924321e-09 NA NA NA hsa-miR-508-3p TGFBR2 1.05493034310846 0.0393857095042515 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.119214194503115 1.55583026735658e-07 NA NA NA hsa-miR-590-3p TGFBR2 2.59289455139753 1.03200520972022e-21 -1.5612933795263 2.09571393414153e-11 miRanda -0.298641027773627 2.0141780556407e-13 NA NA NA hsa-miR-590-5p TGFBR2 3.18300989862077 2.06813568597893e-26 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.294796030766598 2.66958610835318e-16 NA NA NA hsa-miR-9-5p TGFBR2 1.02304182473283 0.042901377604859 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.120425377888386 8.76751437160767e-08 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 2.06460102658973 1.44784291084757e-19 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.402171657787311 8.61853387794715e-18 NA NA NA hsa-miR-93-5p TGFBR2 3.03961860136032 1.11672209617395e-24 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.345215781740609 4.92958365930485e-23 NA NA NA hsa-let-7a-3p THBS1 1.42015538786275 7.03375209382654e-13 -2.1277814514878 2.63898598170147e-08 mirMAP -0.324256229204835 0.000499512291196202 NA NA NA hsa-let-7a-5p THBS1 0.618599506841644 2.76973453058748e-05 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate;TargetScan -0.793931296421232 4.01263206453322e-10 NA NA NA hsa-let-7b-5p THBS1 0.604314269683977 0.00140009936153214 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.3783572455659 0.00015103278303974 NA NA NA hsa-let-7d-5p THBS1 1.33236798905207 1.1741085658466e-13 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.859220357114439 4.03379037942602e-18 NA NA NA hsa-miR-151a-3p THBS1 1.24018761527407 1.08839919675408e-07 -2.1277814514878 2.63898598170147e-08 MirTarget -0.694569328638858 1.06745479684608e-19 NA NA NA hsa-miR-16-1-3p THBS1 2.56983217111073 3.02262181237943e-20 -2.1277814514878 2.63898598170147e-08 MirTarget -0.547933930739432 9.0287268587793e-18 NA NA NA hsa-miR-17-5p THBS1 3.2710598467455 9.93128340539455e-27 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.535410262786805 2.01390645555519e-22 NA NA NA hsa-miR-181a-5p THBS1 2.29556023480783 1.8138457900616e-21 -2.1277814514878 2.63898598170147e-08 mirMAP -0.311799903081761 2.56428301535389e-05 NA NA NA hsa-miR-181b-5p THBS1 2.49307679431293 3.92829250217627e-20 -2.1277814514878 2.63898598170147e-08 mirMAP -0.286545329851077 1.38651496488125e-05 NA NA NA hsa-miR-181c-5p THBS1 1.58587920618301 1.57506918816933e-10 -2.1277814514878 2.63898598170147e-08 mirMAP -0.509013456937225 2.75401083927959e-12 NA NA NA hsa-miR-182-5p THBS1 3.53923166221814 5.07781258121574e-21 -2.1277814514878 2.63898598170147e-08 MirTarget -0.464276709680251 4.8914160255443e-25 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 1.47445398888668 3.0781726595413e-15 -2.1277814514878 2.63898598170147e-08 mirMAP -0.790631830268256 8.0462867743067e-17 NA NA NA hsa-miR-18a-5p THBS1 3.78535678765353 3.72446596213886e-26 -2.1277814514878 2.63898598170147e-08 MirTarget -0.35804586565731 2.12561579001182e-12 NA NA NA hsa-miR-19a-3p THBS1 3.42309334186656 3.02671914353412e-28 -2.1277814514878 2.63898598170147e-08 MirTarget;mirMAP -0.479011511951586 1.31597383903182e-18 NA NA NA hsa-miR-19b-3p THBS1 2.49529833021187 1.57028265846699e-23 -2.1277814514878 2.63898598170147e-08 MirTarget;mirMAP -0.632469943962746 2.39270341905539e-20 NA NA NA hsa-miR-200a-5p THBS1 3.86316681673704 1.81076942093171e-15 -2.1277814514878 2.63898598170147e-08 MirTarget -0.396991686050601 3.54394977146249e-30 NA NA NA hsa-miR-200b-5p THBS1 2.54484902707822 1.59240467582976e-06 -2.1277814514878 2.63898598170147e-08 MirTarget -0.404286942819477 1.05447906162297e-27 NA NA NA hsa-miR-20a-5p THBS1 3.15577933619191 4.19753346442454e-25 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.555674406219999 6.63212782868049e-24 NA NA NA hsa-miR-3065-5p THBS1 2.74629919868982 1.86846589298284e-08 -2.1277814514878 2.63898598170147e-08 MirTarget -0.272591193657042 2.35925406869001e-09 NA NA NA hsa-miR-32-5p THBS1 2.34056473219422 6.24134585974322e-20 -2.1277814514878 2.63898598170147e-08 mirMAP -0.532149898174492 6.38170990221277e-15 NA NA NA hsa-miR-335-3p THBS1 3.08791651139852 5.31309869723517e-12 -2.1277814514878 2.63898598170147e-08 mirMAP -0.184976537215221 5.11650202408596e-06 NA NA NA hsa-miR-33a-3p THBS1 1.72765312072219 1.51784443453521e-07 -2.1277814514878 2.63898598170147e-08 MirTarget;mirMAP -0.543323514403514 5.49591905485477e-20 NA NA NA hsa-miR-375 THBS1 1.13910305294079 0.0512283522214186 -2.1277814514878 2.63898598170147e-08 miRanda -0.150506420398144 2.2392975982835e-06 NA NA NA hsa-miR-421 THBS1 1.17791565395543 6.78526676976629e-06 -2.1277814514878 2.63898598170147e-08 miRanda -0.423737249967144 1.77998923967034e-09 NA NA NA hsa-miR-450b-5p THBS1 1.69244418548325 1.68064054148881e-10 -2.1277814514878 2.63898598170147e-08 MirTarget -0.175596375829618 0.0118513762514108 NA NA NA hsa-miR-491-5p THBS1 0.615770352820862 0.0418295628761654 -2.1277814514878 2.63898598170147e-08 miRanda -0.325347677729002 8.67284344402748e-07 NA NA NA hsa-miR-500a-5p THBS1 1.72110365584658 3.0807246212659e-10 -2.1277814514878 2.63898598170147e-08 mirMAP -0.230571146840421 0.000634888611580494 NA NA NA hsa-miR-576-5p THBS1 2.20467023993664 3.4053475193793e-19 -2.1277814514878 2.63898598170147e-08 mirMAP -0.534982297177329 6.59187971715022e-14 NA NA NA hsa-miR-589-3p THBS1 2.51971841868825 2.39125940264107e-11 -2.1277814514878 2.63898598170147e-08 mirMAP -0.296840513596274 5.92807281377074e-08 NA NA NA hsa-miR-590-3p THBS1 2.59289455139753 1.03200520972022e-21 -2.1277814514878 2.63898598170147e-08 miRanda -0.503581788401113 2.48033554789491e-14 NA NA NA hsa-miR-590-5p THBS1 3.18300989862077 2.06813568597893e-26 -2.1277814514878 2.63898598170147e-08 miRanda;mirMAP -0.527120722441568 1.25825852850212e-19 NA NA NA hsa-miR-629-3p THBS1 2.36570947321815 1.33458201201618e-11 -2.1277814514878 2.63898598170147e-08 MirTarget -0.227068483079105 0.000123952249921696 NA NA NA hsa-miR-664a-3p THBS1 0.634721925861133 0.00520070178640421 -2.1277814514878 2.63898598170147e-08 mirMAP -0.570820389169422 2.01213211719281e-12 NA NA NA hsa-miR-671-5p THBS1 2.97733652243246 1.21148452344738e-23 -2.1277814514878 2.63898598170147e-08 MirTarget -0.50692748391382 1.23943837944331e-16 NA NA NA hsa-miR-7-1-3p THBS1 1.84950311431067 1.25300363397654e-13 -2.1277814514878 2.63898598170147e-08 MirTarget;mirMAP -0.527473744629066 1.61947893119384e-13 NA NA NA hsa-miR-92a-3p THBS1 2.06460102658973 1.44784291084757e-19 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.769477829682195 9.27438286986465e-25 NA NA NA hsa-miR-940 THBS1 3.21011374578759 2.7923171128495e-14 -2.1277814514878 2.63898598170147e-08 MirTarget -0.39529960019763 2.55260567750224e-18 NA NA NA hsa-miR-944 THBS1 2.91186649218281 1.31574753528144e-06 -2.1277814514878 2.63898598170147e-08 MirTarget;PITA -0.199538618837297 1.63491480056503e-10 NA NA NA hsa-miR-98-5p THBS1 1.11154309866014 1.24143909012085e-08 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.724389356283188 5.99048052515149e-15 NA NA NA hsa-miR-106a-5p THBS2 2.48882002962836 1.99757727374521e-12 -0.819009338080235 0.127001426128545 MirTarget -0.45330116032702 9.62830193644936e-11 NA NA NA hsa-miR-106b-5p THBS2 2.46782146831112 1.36171495805632e-23 -0.819009338080235 0.127001426128545 MirTarget -0.72193483715216 1.20112772084899e-13 NA NA NA hsa-miR-16-2-3p THBS2 2.31623086727196 4.29838149388188e-20 -0.819009338080235 0.127001426128545 mirMAP -0.579127576562822 2.3897295143244e-09 NA NA NA hsa-miR-17-5p THBS2 3.2710598467455 9.93128340539455e-27 -0.819009338080235 0.127001426128545 MirTarget;TargetScan -0.513157286321094 5.2287894266298e-11 NA NA NA hsa-miR-182-5p THBS2 3.53923166221814 5.07781258121574e-21 -0.819009338080235 0.127001426128545 MirTarget;miRNATAP -0.378179542663928 4.95986922868172e-09 NA NA NA hsa-miR-20a-5p THBS2 3.15577933619191 4.19753346442454e-25 -0.819009338080235 0.127001426128545 MirTarget -0.524692617570923 2.5011034764088e-11 NA NA NA hsa-miR-20b-5p THBS2 2.07706563022469 1.10107236083433e-05 -0.819009338080235 0.127001426128545 MirTarget -0.34463233280832 9.76692709595905e-11 NA NA NA hsa-miR-29b-3p THBS2 1.65828197923813 1.02676780888141e-09 -0.819009338080235 0.127001426128545 MirTarget -0.207168863270378 0.027846713924368 NA NA NA hsa-miR-29c-3p THBS2 -0.00968972577705429 0.97099586346872 -0.819009338080235 0.127001426128545 MirTarget -0.227132522036715 0.0206349380901597 NA NA NA hsa-miR-32-3p THBS2 2.02436999565685 5.94091197945307e-09 -0.819009338080235 0.127001426128545 miRNATAP -0.439958956826284 1.04187343353676e-07 NA NA NA hsa-miR-320a THBS2 0.438165828017084 0.0390159073347133 -0.819009338080235 0.127001426128545 mirMAP -0.738913348853994 1.08030683289646e-09 NA NA NA hsa-miR-320b THBS2 1.55692969039548 1.41071034251915e-08 -0.819009338080235 0.127001426128545 mirMAP -0.576382788700426 3.09497468053932e-10 NA NA NA hsa-miR-3614-5p THBS2 2.17736331059655 2.19144831318484e-08 -0.819009338080235 0.127001426128545 miRNATAP -0.172742549544423 0.011117304822606 NA NA NA hsa-miR-582-3p THBS2 0.00876844181512659 0.977126166214707 -0.819009338080235 0.127001426128545 miRNATAP -0.362802196964235 1.83546472971205e-05 NA NA NA hsa-miR-590-3p THBS2 2.59289455139753 1.03200520972022e-21 -0.819009338080235 0.127001426128545 miRanda;mirMAP -0.415992971199857 8.15429265241593e-06 NA NA NA hsa-miR-590-5p THBS2 3.18300989862077 2.06813568597893e-26 -0.819009338080235 0.127001426128545 miRanda -0.373930357407742 7.01724345875243e-06 NA NA NA hsa-miR-598-3p THBS2 0.760968346755936 0.027870939187342 -0.819009338080235 0.127001426128545 MirTarget -0.585284197674181 6.99576512493496e-16 NA NA NA hsa-miR-7-1-3p THBS2 1.84950311431067 1.25300363397654e-13 -0.819009338080235 0.127001426128545 MirTarget;mirMAP -0.465723609777495 3.68568678198485e-06 NA NA NA hsa-miR-9-5p THBS2 1.02304182473283 0.042901377604859 -0.819009338080235 0.127001426128545 miRNATAP -0.139117281625275 0.00664593677825042 NA NA NA hsa-miR-93-5p THBS2 3.03961860136032 1.11672209617395e-24 -0.819009338080235 0.127001426128545 MirTarget -0.631952471595904 3.23254182973957e-15 NA NA NA hsa-miR-96-5p THBS2 4.89433085814374 1.92000659886961e-31 -0.819009338080235 0.127001426128545 TargetScan;miRNATAP -0.333472922491884 8.9160648870827e-09 NA NA NA hsa-miR-423-5p THBS3 0.963563145758616 9.86109015204915e-07 -0.433511810214603 0.0373666205114857 PITA;miRNATAP -0.101150323733681 0.0481432565006239 NA NA NA hsa-miR-550a-5p THBS3 2.11025227932763 6.94489556637146e-12 -0.433511810214603 0.0373666205114857 MirTarget -0.131739842044515 3.61387503138023e-05 NA NA NA hsa-miR-320a THBS4 0.438165828017084 0.0390159073347133 -1.61386852407018 0.022417160956919 miRanda -0.961924839649886 1.83285453703857e-09 NA NA NA hsa-miR-320b THBS4 1.55692969039548 1.41071034251915e-08 -1.61386852407018 0.022417160956919 miRanda -0.79406795149706 4.51318828279766e-11 NA NA NA hsa-miR-203a-3p TNF 3.12352008343999 9.49391438647189e-07 0.168287325738871 0.711715304997615 miRTarBase -0.111842196318691 0.000983994485349752 NA NA NA hsa-miR-320a TNF 0.438165828017084 0.0390159073347133 0.168287325738871 0.711715304997615 miRanda -0.394855461451853 0.0001481103227567 NA NA NA hsa-miR-361-5p TNF 0.971859117235239 5.30236555707088e-09 0.168287325738871 0.711715304997615 miRanda -0.363396990950332 0.00589234482466197 NA NA NA hsa-miR-429 TNF 4.48815175680773 2.44117492218206e-17 0.168287325738871 0.711715304997615 miRNATAP -0.169293563460319 1.87983425787946e-05 NA NA NA hsa-miR-21-5p ZFYVE16 2.73773305747971 1.38864982139576e-43 -0.334209102997813 0.0108732777592955 miRNAWalker2_validate -0.145013576555871 4.50528195526375e-07 NA NA NA hsa-miR-221-3p ZFYVE16 0.451556679024397 0.0909808299917811 -0.334209102997813 0.0108732777592955 MirTarget -0.143456364995072 8.58586517791781e-10 NA NA NA hsa-miR-222-3p ZFYVE16 0.851783756239071 0.00266783568486918 -0.334209102997813 0.0108732777592955 miRNAWalker2_validate;MirTarget -0.130886649294437 2.51533049848173e-09 NA NA NA hsa-miR-130a-3p ZFYVE9 2.02021855058359 1.26427102520415e-11 -0.572918805001168 0.00124154305711493 MirTarget;miRNATAP -0.100957641227462 0.000327854113500291 NA NA NA hsa-miR-22-3p ZFYVE9 1.21545661147757 1.61670170137775e-13 -0.572918805001168 0.00124154305711493 MirTarget;miRNATAP -0.136563998054741 0.00807693726627178 NA NA NA hsa-miR-222-3p ZFYVE9 0.851783756239071 0.00266783568486918 -0.572918805001168 0.00124154305711493 miRNAWalker2_validate -0.133339453953243 9.47783049517976e-06 NA NA NA hsa-miR-454-3p ZFYVE9 2.47234127820054 1.12878018736016e-21 -0.572918805001168 0.00124154305711493 MirTarget;miRNATAP -0.106040841739977 0.0011338731788729 NA NA NA