miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-155-5p ABCC4 -0.390065076746791 0.789448799448956 -0.0243094772091963 0.97700436672504 miRNAWalker2_validate -0.22356726271064 0.00217520883591718 NA NA NA hsa-miR-155-5p ABL2 -0.390065076746791 0.789448799448956 0.0899424861414273 0.914677425988542 mirMAP -0.110594255322178 0.00073993944049787 NA NA NA hsa-miR-155-5p ACSL6 -0.390065076746791 0.789448799448956 1.05433514052667 0.171117369930693 mirMAP -0.946169076767768 9.72664825183171e-06 NA NA NA hsa-miR-155-5p ADD3 -0.390065076746791 0.789448799448956 0.137605265647855 0.91713052695358 MirTarget;miRNATAP -0.13034404986139 0.00220656266841026 NA NA NA hsa-miR-155-5p AGTR1 -0.390065076746791 0.789448799448956 0.219787345006046 0.753748808797912 miRNAWalker2_validate;miRTarBase -0.579768813195615 0.000727705674203372 22525818 MicroRNA-155 miR-155 is one of the micro RNAs miRNA most consistently involved in neoplastic diseases and it is known to repress the angiotensin II type 1 receptor AGTR1; The aim of the present study was to evaluate the expressions of miR-155 and AGTR1 and to clarify the potential efficacy of anti-miR-155 alone and in combination with AGTR1 blocker losartan in endometrial cancers; Expressions of miR-155 and AGTR1 were evaluated using real-time PCR and immunohistochemistry; miR-155 was over-expressed and AGTR1 was underexpressed in endometrial carcinoma tissues; We checked that abolishing the function of miR-155 and AGTR1 by anti-miR-155 or losartan inhibited cell survival of endometrial carcinoma cells respectively and furthermore combined treatment showed synergistic effects; In this study we characterized the expressions of miR-155 and AGTR1 in endometrial tissues; The combined treatment with anti-miR-155 and losartan has a synergistic antiproliferative effect and an improved understanding is required to clarify whether miR-155 and AGTR1 can be used as a novel therapeutic target in endometrial cancer poor survival endometrial cancer hsa-miR-155-5p ALDH5A1 -0.390065076746791 0.789448799448956 0.0444386657770712 0.962313885207071 miRNAWalker2_validate -0.13404240564088 0.0100663166021557 NA NA NA hsa-miR-155-5p AMIGO2 -0.390065076746791 0.789448799448956 0.192566348034283 0.803646888297684 miRNAWalker2_validate -0.211854106980138 0.0142901456926943 NA NA NA hsa-miR-155-5p ANKH -0.390065076746791 0.789448799448956 0.206766273734901 0.86723626560705 mirMAP -0.333556472462788 9.19842369340696e-12 NA NA NA hsa-miR-155-5p ARHGAP18 -0.390065076746791 0.789448799448956 0.0772894131733279 0.941220066775728 MirTarget -0.13907302655048 0.000640429944969117 NA NA NA hsa-miR-155-5p ARL15 -0.390065076746791 0.789448799448956 0.327785484939614 0.627894689746305 miRNAWalker2_validate;miRNATAP -0.148122541254252 0.000538294817549666 NA NA NA hsa-miR-155-5p ARMC2 -0.390065076746791 0.789448799448956 -0.0911343317991993 0.752692477926973 miRNAWalker2_validate -0.218780764466642 0.00128367251443503 NA NA NA hsa-miR-155-5p ASNS -0.390065076746791 0.789448799448956 0.381120952333099 0.713174628671469 miRNAWalker2_validate -0.15979239544977 0.0051695971730561 NA NA NA hsa-miR-155-5p ATP6V1H -0.390065076746791 0.789448799448956 0.0172126522681655 0.986335645619108 miRNAWalker2_validate -0.126456308543111 0.000105539513995649 NA NA NA hsa-miR-155-5p ATRNL1 -0.390065076746791 0.789448799448956 0.292828799424034 0.666071482425946 MirTarget;mirMAP -0.471575808407457 0.00111276151201643 NA NA NA hsa-miR-155-5p BCORL1 -0.390065076746791 0.789448799448956 0.0803617801749184 0.92002586144735 MirTarget -0.104216982318677 0.0155509168454803 NA NA NA hsa-miR-155-5p BRPF3 -0.390065076746791 0.789448799448956 0.0661062981757317 0.950059476710452 miRNAWalker2_validate;miRTarBase -0.170308802379296 8.31943906400173e-07 NA NA NA hsa-miR-155-5p BRWD3 -0.390065076746791 0.789448799448956 0.131990950347702 0.847705494033021 miRNATAP -0.190222057845978 0.000120032639817199 NA NA NA hsa-miR-155-5p CAB39L -0.390065076746791 0.789448799448956 0.423538139726592 0.576638895081392 miRNAWalker2_validate -0.569358116596561 4.43070771861796e-08 NA NA NA hsa-miR-155-5p CACNB4 -0.390065076746791 0.789448799448956 0.218278881507073 0.590180889099564 mirMAP;miRNATAP -0.322545608907172 0.00254756691093068 NA NA NA hsa-miR-155-5p CADM2 -0.390065076746791 0.789448799448956 0.76164371553554 0.438598267210449 mirMAP -0.267418833146706 0.0424467554417406 NA NA NA hsa-miR-155-5p CARS2 -0.390065076746791 0.789448799448956 0.128571592589663 0.903072080420478 miRNAWalker2_validate -0.10264741607968 0.0145254343414211 NA NA NA hsa-miR-155-5p CAT -0.390065076746791 0.789448799448956 0.0880999697824407 0.940262859978198 miRNAWalker2_validate -0.131158808388624 0.000867777096454445 NA NA NA hsa-miR-155-5p CDH13 -0.390065076746791 0.789448799448956 0.105671804272769 0.871932126174239 miRNAWalker2_validate -0.325461402335509 3.3085048220923e-07 NA NA NA hsa-miR-155-5p CDH6 -0.390065076746791 0.789448799448956 0.197456780001753 0.56313641550259 miRNAWalker2_validate -0.275420233481457 0.000121544609713351 NA NA NA hsa-miR-155-5p CDX1 -0.390065076746791 0.789448799448956 0.0157523674154962 0.990629830121719 MirTarget -0.206690782078759 0.0202993711537692 NA NA NA hsa-miR-155-5p CEP68 -0.390065076746791 0.789448799448956 0.0125861409563637 0.988514005385529 MirTarget -0.202563066008563 3.53045003628329e-08 NA NA NA hsa-miR-155-5p CFL2 -0.390065076746791 0.789448799448956 -0.0597606811993607 0.920855190144478 miRNAWalker2_validate -0.128165564297617 0.0472984277607173 NA NA NA hsa-miR-155-5p CHD9 -0.390065076746791 0.789448799448956 -0.0283830695546383 0.975003080015186 miRNAWalker2_validate -0.100812162160718 0.00688131209133181 NA NA NA hsa-miR-155-5p CLDN1 -0.390065076746791 0.789448799448956 0.500413750939686 0.676141838192712 miRNAWalker2_validate;miRTarBase -0.237004247910523 0.00591542932340313 23523916;23588589 MicroRNA 155 is a novel suppressor of ovarian cancer initiating cells that targets CLDN1; Here we show that the downregulation of miR-155 in OCICs correlates with CLDN1 overexpression and the suppression of OCIC invasion; Luciferase assays indicate that miR-155 targets CLDN1 mRNA on the 3' UTR; Thus overexpression of miR-155 may prevent tumorigenesis in human ovarian cancer through downregulation of CLDN1;Upregulation of microRNA 155 promotes the migration and invasion of colorectal cancer cells through the regulation of claudin 1 expression; Furthermore the overexpression of miR-155 upregulated claudin-1 expression; Thus our data suggest that miR-155 plays an important role in promoting CRC cell migration and invasion at least in part through the regulation of claudin-1 expression and controlling metastasis in CRC tumorigenesis;metastasis;cell migration ovarian cancer;colorectal cancer hsa-miR-155-5p CLIC4 -0.390065076746791 0.789448799448956 0.215735749260222 0.855993081962764 miRNAWalker2_validate -0.196893572025098 0.000808199420729912 NA NA NA hsa-miR-155-5p CNTN3 -0.390065076746791 0.789448799448956 1.00303075578651 0.100093884704536 MirTarget -0.382317203042955 0.0231865507906551 NA NA NA hsa-miR-155-5p COBLL1 -0.390065076746791 0.789448799448956 0.14537836801588 0.863285455344949 mirMAP -0.243195610958662 1.29815257393277e-06 NA NA NA hsa-miR-155-5p CSE1L -0.390065076746791 0.789448799448956 0.120993264655115 0.928566016623311 miRNAWalker2_validate -0.128888184011906 0.00186569730461495 NA NA NA hsa-miR-155-5p CTNNBL1 -0.390065076746791 0.789448799448956 0.106592764742756 0.921641276620645 miRNAWalker2_validate -0.139343780209414 0.00130046526793748 NA NA NA hsa-miR-155-5p CUL4B -0.390065076746791 0.789448799448956 0.142613903261238 0.898374040235016 miRNAWalker2_validate -0.150481657563666 3.75627403338503e-07 NA NA NA hsa-miR-155-5p CUX1 -0.390065076746791 0.789448799448956 0.000160164712922573 0.999899110219177 miRNAWalker2_validate -0.148803810378574 7.13517799107534e-05 NA NA NA hsa-miR-155-5p DET1 -0.390065076746791 0.789448799448956 0.0329451905339955 0.941834315127424 miRNAWalker2_validate;miRTarBase -0.105990655206556 0.000729604892484504 NA NA NA hsa-miR-155-5p DIXDC1 -0.390065076746791 0.789448799448956 -0.0740374717434391 0.914442118266331 MirTarget -0.143946761162661 0.00694140844328698 NA NA NA hsa-miR-155-5p DMD -0.390065076746791 0.789448799448956 0.0625785004884842 0.921851825735652 miRNAWalker2_validate -0.566400822960453 2.05223332008571e-07 NA NA NA hsa-miR-155-5p DYNC1I1 -0.390065076746791 0.789448799448956 0.561316733191602 0.243862499439089 MirTarget;miRNATAP -0.418331257658278 0.000936375824075487 NA NA NA hsa-miR-155-5p EEF1A2 -0.390065076746791 0.789448799448956 0.548411719175911 0.354558733815185 miRNAWalker2_validate -0.345425189653645 0.0356287154966485 NA NA NA hsa-miR-155-5p EIF3E -0.390065076746791 0.789448799448956 0.186884250752392 0.904599715721318 miRNAWalker2_validate -0.193694744637422 4.13648009951952e-06 NA NA NA hsa-miR-155-5p ELAVL2 -0.390065076746791 0.789448799448956 1.48752953948544 0.0380467941150793 miRNATAP -0.815869033630778 6.17192719433838e-06 NA NA NA hsa-miR-155-5p ETNK2 -0.390065076746791 0.789448799448956 0.165401762208693 0.670353377052634 miRNATAP -0.55706893201914 7.2576372846351e-08 NA NA NA hsa-miR-155-5p FAM105A -0.390065076746791 0.789448799448956 0.261188303455579 0.813609807982247 MirTarget -0.349464472359194 5.1418811139839e-08 NA NA NA hsa-miR-155-5p FNDC3B -0.390065076746791 0.789448799448956 0.10774941291809 0.925766153317434 miRNAWalker2_validate -0.114612165523082 0.00292233191174269 NA NA NA hsa-miR-155-5p FOXO3 -0.390065076746791 0.789448799448956 -0.2469470052884 0.825251189987244 miRNAWalker2_validate;miRTarBase -0.14130550077605 0.000735911240838006 27596294;25480585;20371610;26398931;22027557;27107135 MiR-155 targets 3´UTR region of multiple components of the pro-oncogenic signaling cascades including FOXO3a tumor suppressor and RUNX2 transcription factor regulating metastatic potential in BC;The effect of miRNA155 on FOXO3a expression was examined by Western blotting; FOXO3a was found to be a possible target of miRNA155 as suggested by Targetscan website;MicroRNA 155 regulates cell survival growth and chemosensitivity by targeting FOXO3a in breast cancer; In this study we demonstrate the critical role of miR-155 in regulation of cell survival and chemosensitivity through down-regulation of FOXO3a in breast cancer; Further we identified FOXO3a as a direct target of miR-155; Sustained overexpression of miR-155 resulted in repression of FOXO3a protein without changing mRNA levels and knockdown of miR-155 increases FOXO3a; Finally inverse correlation between miR-155 and FOXO3a levels were observed in a panel of breast cancer cell lines and tumors; In conclusion our study reveals a molecular link between miR-155 and FOXO3a and presents evidence that miR-155 is a critical therapeutic target in breast cancer;In contrast downregulation of miR-155-5p increased sensitivity to bufalin and upregulated the expression of FOXO3A;Here we show that hypoxic conditions induce miR-155 expression in lung cancer cells and trigger a corresponding decrease in a validated target FOXO3A;Our results further revealed that forkhead box O3a FoxO3a was a miR-155 target in the heart; And miR-155 directly repressed FoxO3a whose expression was mitigated in miR-155 agomir and mimic treatment in vivo and in vitro ;;poor survival;;; breast cancer;lymphoma;breast cancer;breast cancer;lung cancer;breast cancer hsa-miR-155-5p FOXP4 -0.390065076746791 0.789448799448956 -0.0616964690193367 0.961648392865646 mirMAP -0.194268683159078 9.74979777420814e-07 NA NA NA hsa-miR-155-5p FRYL -0.390065076746791 0.789448799448956 -0.10589676801886 0.928984607730682 miRNATAP -0.158837689076701 0.00041187595831504 NA NA NA hsa-miR-155-5p FSD1L -0.390065076746791 0.789448799448956 0.188367364533949 0.706828687102281 mirMAP -0.175624378620613 0.00574220284909029 NA NA NA hsa-miR-155-5p GABRB2 -0.390065076746791 0.789448799448956 0.871947102064475 0.223637656353772 mirMAP -0.579169366862194 0.00300014626207269 NA NA NA hsa-miR-155-5p GFPT1 -0.390065076746791 0.789448799448956 -0.0896571181699031 0.95113212697657 mirMAP -0.113154309042091 0.00997548503245709 NA NA NA hsa-miR-155-5p GLB1 -0.390065076746791 0.789448799448956 0.0570561920868551 0.962977002959893 miRNAWalker2_validate -0.157130347634854 3.25540358289653e-08 NA NA NA hsa-miR-155-5p GNAS -0.390065076746791 0.789448799448956 -0.0800908505786602 0.963117196637563 miRNAWalker2_validate;MirTarget -0.141899593119127 0.000832629260585035 NA NA NA hsa-miR-155-5p GPM6B -0.390065076746791 0.789448799448956 -0.0225994672116153 0.943817274396123 miRNAWalker2_validate;MirTarget -0.260475848675562 0.00565265263074205 NA NA NA hsa-miR-155-5p GRIP1 -0.390065076746791 0.789448799448956 0.494406976590562 0.207481659389769 miRNATAP -0.472122821285509 2.92705443814747e-05 NA NA NA hsa-miR-155-5p GSK3B -0.390065076746791 0.789448799448956 0.0590816687078393 0.956737686939354 miRNAWalker2_validate;miRNATAP -0.101330604682835 1.443796438774e-06 NA NA NA hsa-miR-155-5p GYG1 -0.390065076746791 0.789448799448956 0.106741313559147 0.911809134185666 MirTarget -0.121446596075094 2.87013005171158e-05 NA NA NA hsa-miR-155-5p H3F3A -0.390065076746791 0.789448799448956 0.0623394955994474 0.964888138975339 MirTarget;miRNATAP -0.10627424716698 0.00259204325091231 NA NA NA hsa-miR-155-5p HBP1 -0.390065076746791 0.789448799448956 0.00948275633888152 0.992809958506548 miRNAWalker2_validate;MirTarget;miRNATAP -0.102389223802555 0.00107923180808917 25666090 miR 155 promotes the growth of osteosarcoma in a HBP1 dependent mechanism; HMG-box transcription factor 1 HBP1 a strong Wnt pathway suppressor was found to be a target of miR-155; Restoration of HBP1 abolished the effect of miR-155 on OS cells sarcoma hsa-miR-155-5p HDAC2 -0.390065076746791 0.789448799448956 -0.0230996297758708 0.985548499830413 mirMAP -0.109762222433032 0.000364165078781078 21946536 Mechanistically we found that BRCA1 epigenetically represses miR-155 expression via its association with HDAC2 which deacetylates histones H2A and H3 on the miR-155 promoter breast cancer hsa-miR-155-5p HSD17B12 -0.390065076746791 0.789448799448956 0.0475320506519896 0.970420640745417 miRNAWalker2_validate -0.10726913098444 0.0231250046139573 NA NA NA hsa-miR-155-5p HSDL1 -0.390065076746791 0.789448799448956 0.157293219455989 0.841610915478211 miRNAWalker2_validate -0.154714920211495 7.23017772606673e-08 NA NA NA hsa-miR-155-5p HUNK -0.390065076746791 0.789448799448956 0.399129361309349 0.657643407510396 mirMAP -0.401538915199839 0.00396328265484695 NA NA NA hsa-miR-155-5p IGDCC4 -0.390065076746791 0.789448799448956 -0.143048659469432 0.729513346294874 MirTarget -0.169989937035704 0.0386785131237711 NA NA NA hsa-miR-155-5p IGF1R -0.390065076746791 0.789448799448956 -0.0196522944103243 0.984937158910044 mirMAP -0.157172052561045 0.000741470115136315 NA NA NA hsa-miR-155-5p IL17RD -0.390065076746791 0.789448799448956 0.0252987099929869 0.967417841019117 mirMAP -0.396603092965329 7.39463573252388e-06 NA NA NA hsa-miR-155-5p IRF2BP2 -0.390065076746791 0.789448799448956 0.0780906180406475 0.95705362907937 MirTarget;miRNATAP -0.171796303511806 1.76124606183574e-08 NA NA NA hsa-miR-155-5p JARID2 -0.390065076746791 0.789448799448956 0.0774030020408079 0.927087044365374 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.102711952783292 0.00357821867532521 23185331 We furthermore identify Jarid2 a component of Polycomb repressive complex 2 as a novel validated target of miR-K12-11 and confirm its downregulation in miR-K12-11 as well as miR-155 expressing bone marrow cells sarcoma hsa-miR-155-5p JUN -0.390065076746791 0.789448799448956 -0.197463396614254 0.891676022535147 miRNAWalker2_validate;miRTarBase -0.142048588673909 0.0138631645666983 23693020 In the present study we demonstrated for the first time that activation of RAGE by S100P regulates oncogenic microRNA-155 miR-155 expression through Activator Protein-1 AP-1 stimulation in colon cancer cells colon cancer hsa-miR-155-5p KANK2 -0.390065076746791 0.789448799448956 -0.0841470113399989 0.933974316035952 miRNAWalker2_validate -0.161486963193335 0.00332241703828364 NA NA NA hsa-miR-155-5p KDELC1 -0.390065076746791 0.789448799448956 0.375602913883079 0.435690014409314 miRNAWalker2_validate -0.144119887664744 0.00777065597977539 NA NA NA hsa-miR-155-5p KDM5B -0.390065076746791 0.789448799448956 -0.0521101392008285 0.962593384458147 MirTarget -0.116530235241121 0.00434529063813276 NA NA NA hsa-miR-155-5p KRT80 -0.390065076746791 0.789448799448956 0.344846586436531 0.713650667980654 miRNAWalker2_validate -0.19418362898941 0.0213919905777946 NA NA NA hsa-miR-155-5p LCA5 -0.390065076746791 0.789448799448956 0.0414206549667195 0.888337149117113 MirTarget -0.165331676611249 0.00742623744394163 NA NA NA hsa-miR-155-5p LEPROT -0.390065076746791 0.789448799448956 0.0600728324753819 0.939627395513409 mirMAP -0.105952799534493 0.0202163016091814 NA NA NA hsa-miR-155-5p LNX2 -0.390065076746791 0.789448799448956 0.267599431061749 0.787122546287237 miRNAWalker2_validate -0.222603686395689 3.8251837544083e-06 NA NA NA hsa-miR-155-5p LONRF2 -0.390065076746791 0.789448799448956 0.0710910439498633 0.922067795656361 mirMAP -0.41182729708014 0.0198095389168321 NA NA NA hsa-miR-155-5p LPP -0.390065076746791 0.789448799448956 -0.164600311590868 0.812347352836452 mirMAP;miRNATAP -0.118420984620066 0.0293278020547544 NA NA NA hsa-miR-155-5p MAP4K3 -0.390065076746791 0.789448799448956 0.0249920900033773 0.97838185891727 MirTarget -0.110998908119207 0.000209317836543566 NA NA NA hsa-miR-155-5p MAVS -0.390065076746791 0.789448799448956 0.0411180459629437 0.973800486869071 miRNAWalker2_validate -0.10229429061461 0.0204090517157509 NA NA NA hsa-miR-155-5p MBLAC2 -0.390065076746791 0.789448799448956 0.231038451673317 0.689294639899091 miRNAWalker2_validate -0.120319182774408 0.00201836713562058 NA NA NA hsa-miR-155-5p MCAM -0.390065076746791 0.789448799448956 0.115274321007779 0.915862059849333 miRNAWalker2_validate -0.159446729885968 0.0058593929611752 NA NA NA hsa-miR-155-5p MEST -0.390065076746791 0.789448799448956 -0.0285979474253022 0.980049721949692 miRNAWalker2_validate -0.190732981923698 2.66749475714808e-05 NA NA NA hsa-miR-155-5p MLH1 -0.390065076746791 0.789448799448956 -0.00541588696872175 0.994620094092696 miRNAWalker2_validate;miRTarBase -0.23388106466595 0.00446918147116009 23715647;21738581 MLH1 as a direct target of MiR 155 and a potential predictor of favorable prognosis in pancreatic cancer; The regulation of Mut L homologue 1 MLH1 expression by microRNA miR-155 and its prognostic significance in pancreatic cancer PC remain to be elucidated; Then luciferase activity was detected after miR-155 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of MLH1 mRNA were co-transfected; Transfection of miR-155 mimics and inhibitor led to reversely altered protein expressions of miR-155 and MLH1 whereas the corresponding mRNA expressions were similar; MLH1 might serve as a direct target of miR-155 and a potential prognosis predictor in PC;Predicted target mRNAs FGFR1 miR-10 and MLH1 miR-155 were found downregulated worse prognosis; pancreatic cancer;pancreatic cancer hsa-miR-155-5p MMP16 -0.390065076746791 0.789448799448956 0.338899796307682 0.329534973786277 mirMAP -0.273564257979527 0.00296625597221081 NA NA NA hsa-miR-155-5p MPP2 -0.390065076746791 0.789448799448956 0.242219871781398 0.357786253022202 miRNAWalker2_validate -0.156700121529146 0.0470296013151219 NA NA NA hsa-miR-155-5p MYO10 -0.390065076746791 0.789448799448956 0.103708597475143 0.936112029597936 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.225481435302771 1.09178323108495e-08 NA NA NA hsa-miR-155-5p MYO1D -0.390065076746791 0.789448799448956 -0.060250094732055 0.96857683685194 miRNAWalker2_validate;miRNATAP -0.155854282446298 0.00125982529138965 NA NA NA hsa-miR-155-5p NES -0.390065076746791 0.789448799448956 -0.0365174831445989 0.969560951046083 miRNAWalker2_validate -0.241411718016191 0.000764954384789968 NA NA NA hsa-miR-155-5p NEU1 -0.390065076746791 0.789448799448956 0.270649478359697 0.823581948494041 miRNAWalker2_validate -0.222961197412861 6.36802980835242e-05 NA NA NA hsa-miR-155-5p NFAT5 -0.390065076746791 0.789448799448956 0.145905651789573 0.894648246585068 mirMAP;miRNATAP -0.15151678093381 0.000258720624622913 NA NA NA hsa-miR-155-5p NFIA -0.390065076746791 0.789448799448956 0.0174045144557109 0.985407996184375 miRNATAP -0.116570337991457 0.0142413511275164 NA NA NA hsa-miR-155-5p NGEF -0.390065076746791 0.789448799448956 0.190508681155308 0.821917183780219 miRNATAP -0.192145042391334 0.00210234312530298 NA NA NA hsa-miR-155-5p NUPL2 -0.390065076746791 0.789448799448956 0.0668008219275702 0.937019052928267 miRNAWalker2_validate -0.102904640722728 0.00474099481563289 NA NA NA hsa-miR-155-5p OLFML3 -0.390065076746791 0.789448799448956 0.231720355483116 0.76151917748099 miRNATAP -0.265937006353989 0.0022102861020993 NA NA NA hsa-miR-155-5p OPHN1 -0.390065076746791 0.789448799448956 0.00432775765615112 0.993917512303684 mirMAP -0.104416203586992 0.0155161696973621 NA NA NA hsa-miR-155-5p PACSIN3 -0.390065076746791 0.789448799448956 -0.163249248628497 0.83197882488051 miRNAWalker2_validate -0.240459240093189 0.0103611115339615 NA NA NA hsa-miR-155-5p PANK1 -0.390065076746791 0.789448799448956 -0.154743914769576 0.855013304001175 miRNATAP -0.130706632359103 0.0163950491819274 NA NA NA hsa-miR-155-5p PCMTD1 -0.390065076746791 0.789448799448956 0.180045407689762 0.856916576213379 mirMAP -0.191458288392622 8.66604296578577e-06 NA NA NA hsa-miR-155-5p PCYOX1 -0.390065076746791 0.789448799448956 0.0172334021211684 0.987769702322042 miRNAWalker2_validate -0.10424723689198 0.000338758457448227 NA NA NA hsa-miR-155-5p PDE1A -0.390065076746791 0.789448799448956 0.324045585934381 0.382993011767269 mirMAP -0.279456418047889 0.00990751682831779 NA NA NA hsa-miR-155-5p PDE3A -0.390065076746791 0.789448799448956 -0.010016681046018 0.986654151985846 miRNAWalker2_validate -0.416506889620344 0.00086386994710836 NA NA NA hsa-miR-155-5p PEG3 -0.390065076746791 0.789448799448956 0.169103806145185 0.626772499309076 miRNATAP -0.24796682921441 0.0173655659866352 NA NA NA hsa-miR-155-5p PFDN4 -0.390065076746791 0.789448799448956 0.223276635413615 0.796620048224512 miRNAWalker2_validate -0.187804029250578 0.00066425308311987 NA NA NA hsa-miR-155-5p PGR -0.390065076746791 0.789448799448956 0.13250471879391 0.746724890069838 mirMAP -0.249628448822859 0.0303629726017722 20388420;19454029;23162645 It's indicated that the up-regulation of miR-155 expression was associated with advanced TNM clinical stage median 0.316 0.358 and 0.417 respectively for stage I II and III tumor P = 0.002 lymph node metastasis median 0.383 and 0.355 respectively for cases with positive and negative lymph nodes P = 0.034 higher proliferation index median 0.387 and 0.353 respectively for cases with high proliferation index Ki67 > 10% and low proliferation index Ki67 ≤ 10% P = 0.019 estrogen receptor-positive 0.367 and 0.318 respectively for cases with positive estrogen receptor and negative group P = 0.041 and progesterone receptor-positive 0.398 and 0.335 respectively for cases with positive progesterone receptor and negative group P = 0.029 in patients with breast cancer; The expression of miR-155 is up-regulated in primary breast cancer especially in patients with positive estrogen and progesterone receptor;While the expression of all three miRNAs was similar in samples from healthy women compared to those with breast cancer women with progesterone receptor PR p = 0.016 positive tumors had higher miR-155 expression than tumors that were negative for these receptors;miR 155 and miR 31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status; The expression levels of miR-155 but not miR-31 were inversely correlated with estrogen receptor ER and progesterone receptor PR expression ER r=-0.353 P=0.003; PR r=-0.357 P=0.003 staging;metastasis;; breast cancer;breast cancer;breast cancer hsa-miR-155-5p PHF14 -0.390065076746791 0.789448799448956 0.103902322506566 0.918280136875254 miRNAWalker2_validate -0.109802092865054 0.000374380703534597 NA NA NA hsa-miR-155-5p PHGDH -0.390065076746791 0.789448799448956 0.808122932776586 0.429891812266927 miRNAWalker2_validate -0.442192138269648 7.21038636030213e-05 NA NA NA hsa-miR-155-5p PLAG1 -0.390065076746791 0.789448799448956 0.56131772338756 0.16053467834354 miRNATAP -0.557350463972035 1.66681423512545e-06 NA NA NA hsa-miR-155-5p PLEKHA5 -0.390065076746791 0.789448799448956 0.107637675615827 0.905897285634981 miRNAWalker2_validate -0.138806428444079 5.00583749712248e-05 NA NA NA hsa-miR-155-5p PNPLA4 -0.390065076746791 0.789448799448956 -0.0948570522495791 0.903193335953705 miRNAWalker2_validate -0.165681582026134 0.0340715048989654 NA NA NA hsa-miR-155-5p POU2F1 -0.390065076746791 0.789448799448956 -0.130147518012917 0.688789219558638 mirMAP -0.115053444275387 0.0255965251733301 NA NA NA hsa-miR-155-5p PRKG1 -0.390065076746791 0.789448799448956 0.272482291689062 0.463875372064371 miRNATAP -0.412023561923618 4.32056626313495e-05 NA NA NA hsa-miR-155-5p PROX1 -0.390065076746791 0.789448799448956 -0.0882284647107094 0.890822867283128 miRNATAP -0.41208907575527 2.34536340155086e-05 NA NA NA hsa-miR-155-5p PTCHD1 -0.390065076746791 0.789448799448956 -0.660442338134084 0.400249832820919 mirMAP -0.362655665695433 0.0257487841860996 NA NA NA hsa-miR-155-5p PUS7 -0.390065076746791 0.789448799448956 -0.0214046817297202 0.981488592883908 miRNAWalker2_validate -0.11137160857967 0.0101518599622125 NA NA NA hsa-miR-155-5p RAB11FIP2 -0.390065076746791 0.789448799448956 0.15571867512021 0.822882926199542 miRNAWalker2_validate;MirTarget;miRNATAP -0.214246623258403 1.17385570547564e-07 NA NA NA hsa-miR-155-5p RAB22A -0.390065076746791 0.789448799448956 0.125527626415039 0.909780012743235 mirMAP -0.110000915742305 0.0027868722033183 NA NA NA hsa-miR-155-5p RAB2A -0.390065076746791 0.789448799448956 -0.150883945643104 0.88759667260925 miRNAWalker2_validate -0.113357166454857 0.00014889580771617 NA NA NA hsa-miR-155-5p RAB6C -0.390065076746791 0.789448799448956 0.225742445192004 0.460927119423348 miRNAWalker2_validate -0.115462673027743 0.0013136132291996 NA NA NA hsa-miR-155-5p RAP2A -0.390065076746791 0.789448799448956 0.206504466967721 0.842465315519244 mirMAP -0.117945260305023 0.00222545390970398 NA NA NA hsa-miR-155-5p RAPGEF2 -0.390065076746791 0.789448799448956 0.0929536604091634 0.923345326141571 miRNAWalker2_validate;MirTarget -0.102251770395245 0.00207291059049159 NA NA NA hsa-miR-155-5p RAPGEF4 -0.390065076746791 0.789448799448956 0.843325740709979 0.0212403439788018 miRNATAP -0.350995949603865 2.47668432869089e-05 NA NA NA hsa-miR-155-5p RBP2 -0.390065076746791 0.789448799448956 0.344552636398776 0.654137428351623 MirTarget -0.825613332285877 0.00037588141356529 NA NA NA hsa-miR-155-5p RCN2 -0.390065076746791 0.789448799448956 0.0863860203764277 0.935822142571427 miRNAWalker2_validate;MirTarget -0.1042960886008 0.00319765081962666 NA NA NA hsa-miR-155-5p REPS2 -0.390065076746791 0.789448799448956 -0.309518966397553 0.725581016946688 MirTarget;miRNATAP -0.197702287220094 0.00131786597884405 NA NA NA hsa-miR-155-5p RHEB -0.390065076746791 0.789448799448956 0.0402808754190724 0.970711183093277 miRNAWalker2_validate;miRNATAP -0.117250793253776 0.000276574591106519 NA NA NA hsa-miR-155-5p RNF2 -0.390065076746791 0.789448799448956 0.156806615521879 0.838723759605022 miRNAWalker2_validate -0.117657828935742 0.000289918386640136 NA NA NA hsa-miR-155-5p RPGRIP1L -0.390065076746791 0.789448799448956 -0.165810143655555 0.768323801315057 mirMAP -0.119737009293532 0.00395816587251208 NA NA NA hsa-miR-155-5p RPL39 -0.390065076746791 0.789448799448956 0.212617275388276 0.820738818436428 miRNAWalker2_validate -0.188189832586885 0.00156848234525275 NA NA NA hsa-miR-155-5p SALL1 -0.390065076746791 0.789448799448956 -0.0276579121806633 0.947309195083684 miRNATAP -0.376614063967613 0.0021444191560728 NA NA NA hsa-miR-155-5p SATB1 -0.390065076746791 0.789448799448956 0.624823012001702 0.462088034297926 MirTarget;miRNATAP -0.372481612391872 1.54200015373978e-05 NA NA NA hsa-miR-155-5p SCAMP1 -0.390065076746791 0.789448799448956 0.154061737664462 0.881388654281961 miRNAWalker2_validate -0.103312330393338 0.000999391740212056 NA NA NA hsa-miR-155-5p SCML2 -0.390065076746791 0.789448799448956 0.342760301039263 0.452542176375399 mirMAP -0.285973362115402 0.0133208650140516 NA NA NA hsa-miR-155-5p SCUBE2 -0.390065076746791 0.789448799448956 0.238302578247363 0.579913726292436 MirTarget -0.441536273614047 9.45002434577504e-05 NA NA NA hsa-miR-155-5p SECISBP2 -0.390065076746791 0.789448799448956 0.137996020497555 0.893538542784373 miRNAWalker2_validate -0.104929004140284 0.000601281231196218 NA NA NA hsa-miR-155-5p SEMA5A -0.390065076746791 0.789448799448956 -0.0242592122510246 0.980635865268344 miRNATAP -0.424394288765735 4.84156928986416e-06 NA NA NA hsa-miR-155-5p SERPINA10 -0.390065076746791 0.789448799448956 0.61484100201508 0.432935220854239 MirTarget -1.43429555006431 2.54164182903501e-11 NA NA NA hsa-miR-155-5p SH3BP4 -0.390065076746791 0.789448799448956 0.000775657165178245 0.999498338059352 miRNAWalker2_validate -0.159143767992138 9.12970938496377e-05 NA NA NA hsa-miR-155-5p SIM2 -0.390065076746791 0.789448799448956 0.288784445234898 0.673089089995711 miRNATAP -0.229684923090594 0.028534452668798 NA NA NA hsa-miR-155-5p SLC13A3 -0.390065076746791 0.789448799448956 0.725311405578122 0.269245067426087 mirMAP -0.905438689312645 3.44318732863841e-06 NA NA NA hsa-miR-155-5p SLC25A36 -0.390065076746791 0.789448799448956 0.156438790456678 0.874619593205223 mirMAP -0.123607611903725 4.00903890390733e-05 NA NA NA hsa-miR-155-5p SLC30A1 -0.390065076746791 0.789448799448956 0.122712974298107 0.870833138700922 miRNAWalker2_validate -0.101373822030978 0.00516088686859727 NA NA NA hsa-miR-155-5p SLC35F5 -0.390065076746791 0.789448799448956 0.0262002083716402 0.978786313316326 MirTarget -0.164778577921785 1.23139417080474e-05 NA NA NA hsa-miR-155-5p SLC39A10 -0.390065076746791 0.789448799448956 0.179559437151438 0.844292596237866 miRNAWalker2_validate;miRNATAP -0.225499718864792 1.63438010128785e-08 NA NA NA hsa-miR-155-5p SLC7A1 -0.390065076746791 0.789448799448956 0.272587936048413 0.834741229696591 miRNAWalker2_validate -0.113689126268807 0.0132639414737526 NA NA NA hsa-miR-155-5p SMAD9 -0.390065076746791 0.789448799448956 -0.545548968373171 0.233548158890283 mirMAP -0.611110057182805 2.59876495237369e-06 NA NA NA hsa-miR-155-5p SORL1 -0.390065076746791 0.789448799448956 0.117149244947559 0.928442774793935 miRNATAP -0.195939532988358 0.000484450069659074 NA NA NA hsa-miR-155-5p SORT1 -0.390065076746791 0.789448799448956 0.0295253428649724 0.98121336372652 MirTarget -0.157476391526141 0.000162166793123946 NA NA NA hsa-miR-155-5p SOX11 -0.390065076746791 0.789448799448956 0.409517845952761 0.302315102406402 miRNATAP -0.343093065747322 0.00221953863518311 NA NA NA hsa-miR-155-5p SOX6 -0.390065076746791 0.789448799448956 0.0467149757618701 0.905658582718304 miRTarBase;miRNATAP -0.279736550384447 0.00981871396960103 21989846 Ectopic expression of sex-determining region Y box 6 SOX6 was able to reverse the growth-promoting property of miR-155; Concordantly the results demonstrated for the first time that SOX6 is a direct target of miR-155; In addition a decline in p21waf1/cip1 expression caused by miR-155 could be reversed by SOX6 expression; The current data indicated that SOX6 is a novel target of miR-155 and that miR-155 enhances liver cell tumorigenesis at least in part through the novel miR-155/SOX6/p21waf1/cip1 axis tumorigenesis liver cancer hsa-miR-155-5p SP3 -0.390065076746791 0.789448799448956 0.0247088697610822 0.982772017138002 MirTarget;miRNATAP -0.114115798670773 1.86347418754167e-06 NA NA NA hsa-miR-155-5p SPIN1 -0.390065076746791 0.789448799448956 0.10467568437134 0.92575357257042 miRNAWalker2_validate -0.106135299394918 8.02058242044843e-07 NA NA NA hsa-miR-155-5p SPRY3 -0.390065076746791 0.789448799448956 -0.0779414288300404 0.788685496169004 mirMAP -0.256025527902892 1.26618493247741e-06 NA NA NA hsa-miR-155-5p STAG2 -0.390065076746791 0.789448799448956 0.0103330266615798 0.993355454017328 miRNAWalker2_validate -0.118067483796486 0.000704542795487221 NA NA NA hsa-miR-155-5p STK38L -0.390065076746791 0.789448799448956 0.117465173629362 0.918120072148183 mirMAP -0.155228441256815 0.000536693350112124 NA NA NA hsa-miR-155-5p STMN2 -0.390065076746791 0.789448799448956 0.663853297153813 0.203026555565999 miRNATAP -0.385648225076717 0.0158807138035536 NA NA NA hsa-miR-155-5p STOX2 -0.390065076746791 0.789448799448956 0.238591057896985 0.713718144563976 mirMAP -0.25025845246558 0.0190061629739736 NA NA NA hsa-miR-155-5p STRN -0.390065076746791 0.789448799448956 0.01003648760154 0.989591635625111 miRNAWalker2_validate -0.110371014262818 0.00673491337661808 NA NA NA hsa-miR-155-5p TBC1D16 -0.390065076746791 0.789448799448956 -0.036332318029241 0.964874445372971 mirMAP -0.125790894332848 0.0125202098471056 NA NA NA hsa-miR-155-5p TMEM123 -0.390065076746791 0.789448799448956 0.115115208186213 0.940053960354037 mirMAP -0.102295017335754 0.00416191618083253 NA NA NA hsa-miR-155-5p TMEM47 -0.390065076746791 0.789448799448956 0.369089362415773 0.57459519761035 mirMAP -0.190237883873848 0.0277153738359086 NA NA NA hsa-miR-155-5p TOMM34 -0.390065076746791 0.789448799448956 0.188379535545647 0.87409374407927 miRNAWalker2_validate -0.120723185821229 0.0147720737035608 NA NA NA hsa-miR-155-5p TRIM2 -0.390065076746791 0.789448799448956 -0.107981579372978 0.935760915708025 miRNATAP -0.226079483504244 2.03263937563952e-05 NA NA NA hsa-miR-155-5p TRIM24 -0.390065076746791 0.789448799448956 -0.0857851394607687 0.930123513993919 miRNAWalker2_validate -0.128596234012594 0.00104990919426092 NA NA NA hsa-miR-155-5p TRIO -0.390065076746791 0.789448799448956 0.0051643920776252 0.996459853257266 miRNAWalker2_validate -0.124476778768145 0.00177855169676359 NA NA NA hsa-miR-155-5p TSPAN5 -0.390065076746791 0.789448799448956 0.441840520386581 0.352000211981213 MirTarget -0.204676491311554 0.00301271979565659 NA NA NA hsa-miR-155-5p TTC37 -0.390065076746791 0.789448799448956 0.250475622501159 0.807475155736457 miRNAWalker2_validate -0.173202894193692 8.21198813251137e-05 NA NA NA hsa-miR-155-5p TYRP1 -0.390065076746791 0.789448799448956 0.234291517151265 0.671675218619137 MirTarget -0.405680653342827 0.00347560770155944 26068396 SNPs at miR 155 binding sites of TYRP1 explain discrepancy between mRNA and protein and refine TYRP1 prognostic value in melanoma; The effect of miR-155 on TYRP1 mRNA/protein expression was evaluated in two melanoma cell lines harbouring matched or mismatched miR-155-TYRP1 mRNA interaction after transfection with pre-miR-155; In parallel 192 skin and lymph node melanoma metastases were examined for TYRP1 mRNA/protein miR-155 and SNPs and correlated with patient survival; TYRP1 mRNA SNPs at its 3'UTR and miR-155 were analysed by RT-qPCR whereas TYRP1 protein was evaluated by western blot in cell lines and by immunohistochemistry in metastatic tissues; The miR-155 induced a dose-dependent TYRP1 mRNA decay and hampered its translation into protein in the line with the 'match' genotype; In melanoma metastases TYRP1 mRNA inversely correlated with miR-155 expression but not with TYRP1 protein in the 'match' group whereas it positively correlated with protein but not with miR-155 in the 'mismatch' group; Polymorphisms in 3'UTR of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR-155 and its subsequent translation into protein; These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR-155 activity and disclose a prognostic value for TYRP1 protein in a subgroup of melanoma patients metastasis;poor survival melanoma hsa-miR-155-5p UBN2 -0.390065076746791 0.789448799448956 -0.0272238229100878 0.975357475482902 mirMAP -0.100970798437722 0.00106698846940818 NA NA NA hsa-miR-155-5p USP37 -0.390065076746791 0.789448799448956 0.18505919176688 0.845723304225611 mirMAP -0.126135019106166 0.000302456304520943 NA NA NA hsa-miR-155-5p VAV3 -0.390065076746791 0.789448799448956 0.640142670283506 0.568311637788162 MirTarget -0.668503575084748 1.73801329663788e-06 NA NA NA hsa-miR-155-5p VEZF1 -0.390065076746791 0.789448799448956 0.05587345126846 0.956789949232712 miRNAWalker2_validate -0.104865901741246 0.000101462999339465 NA NA NA hsa-miR-155-5p VPS13B -0.390065076746791 0.789448799448956 -0.0584914959782692 0.946212034466972 mirMAP -0.113477586152521 0.00470912832866234 NA NA NA hsa-miR-155-5p VPS36 -0.390065076746791 0.789448799448956 0.404481110278418 0.718006525916777 miRNAWalker2_validate -0.135334579006025 0.000601091943141023 NA NA NA hsa-miR-155-5p WNT5A -0.390065076746791 0.789448799448956 0.207307703112464 0.796371366352124 miRNAWalker2_validate;mirMAP -0.223479064174965 0.0100269233130603 NA NA NA hsa-miR-155-5p XPO4 -0.390065076746791 0.789448799448956 0.438815384835297 0.66108021203539 mirMAP -0.116308832871189 0.00471573822884519 NA NA NA hsa-miR-155-5p YIPF6 -0.390065076746791 0.789448799448956 -0.00117327522919197 0.998759649509208 mirMAP -0.100397468329912 0.00201098785688236 NA NA NA hsa-miR-155-5p ZBTB10 -0.390065076746791 0.789448799448956 0.110840293900831 0.875557291680207 mirMAP -0.603984578992188 2.81890808343015e-15 NA NA NA hsa-miR-155-5p ZC3H12B -0.390065076746791 0.789448799448956 0.0183121643128494 0.962803163412801 mirMAP -0.32186108480838 1.38305266125728e-05 NA NA NA hsa-miR-155-5p ZDHHC15 -0.390065076746791 0.789448799448956 0.317555709803641 0.546938163231419 mirMAP -0.243574930913207 0.0236045917759951 NA NA NA hsa-miR-155-5p ZMYM2 -0.390065076746791 0.789448799448956 0.281293960871132 0.794600051357113 MirTarget;miRNATAP -0.202143033985857 1.39800570360426e-06 NA NA NA hsa-miR-155-5p ZNF254 -0.390065076746791 0.789448799448956 -0.0434684143471089 0.948911318746086 miRNAWalker2_validate -0.305759245379954 3.40566056660464e-05 NA NA NA hsa-miR-155-5p ZNF260 -0.390065076746791 0.789448799448956 0.0160988862993001 0.98336907696751 MirTarget -0.154360241808442 0.000671535731550332 NA NA NA hsa-miR-155-5p ZNF273 -0.390065076746791 0.789448799448956 0.0945761483710674 0.839818777867165 miRNAWalker2_validate -0.125577348774566 0.00248890170435094 NA NA NA hsa-miR-155-5p ZNF28 -0.390065076746791 0.789448799448956 0.222445358419185 0.779926822951182 miRNAWalker2_validate -0.232403758744423 0.000162137429846937 NA NA NA hsa-miR-155-5p ZNF33B -0.390065076746791 0.789448799448956 0.231541038107477 0.801698162858738 mirMAP -0.124784362094275 0.00116735970363735 NA NA NA hsa-miR-155-5p ZNF354C -0.390065076746791 0.789448799448956 0.640155325880087 0.180035144993541 mirMAP -0.249174666585646 0.0327863246420109 NA NA NA hsa-miR-155-5p ZNF528 -0.390065076746791 0.789448799448956 0.383082717915307 0.305412805713252 mirMAP -0.30564473587625 0.00405213451923089 NA NA NA hsa-miR-155-5p ZNF703 -0.390065076746791 0.789448799448956 -0.0419680582157795 0.968819460932858 miRNATAP -0.214560923264106 0.000403191460373157 NA NA NA hsa-miR-155-5p ZNF709 -0.390065076746791 0.789448799448956 -0.041542732527893 0.894637452655687 mirMAP -0.162277103169796 0.000568438387496096 NA NA NA hsa-miR-155-5p ZNF792 -0.390065076746791 0.789448799448956 0.0067938560282359 0.990434312948166 mirMAP -0.131213999102421 0.000549015068796483 NA NA NA hsa-miR-155-5p ZNF793 -0.390065076746791 0.789448799448956 0.740244406395069 0.0668611658845602 mirMAP -0.460103057536535 0.000131218447942976 NA NA NA hsa-miR-155-5p ZNF880 -0.390065076746791 0.789448799448956 0.836879776963034 0.0336619012436559 MirTarget -0.362636514355006 0.00201513518635513 NA NA NA hsa-miR-155-5p ZNRF3 -0.390065076746791 0.789448799448956 0.14351158415471 0.886700197968068 miRNATAP -0.316960410333521 7.4577482726866e-08 NA NA NA