miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-107 AIFM1 -0.0765084476717215 0.299642610307986 0.556430777387072 1.84132371877401e-19 miRanda -0.0929336012240128 0.0128878164247404 NA NA NA hsa-miR-125b-5p AIFM1 0.0293874305780122 0.763949843010169 0.556430777387072 1.84132371877401e-19 miRNATAP -0.105961779273774 0.000144562071572006 NA NA NA hsa-miR-143-5p AIFM1 -0.883533872970316 1.50226641151278e-06 0.556430777387072 1.84132371877401e-19 miRNATAP -0.0559342827384993 0.000128658928800976 NA NA NA hsa-miR-145-5p AIFM1 -0.0645550892386986 0.583308140519106 0.556430777387072 1.84132371877401e-19 miRNATAP -0.095404598414906 3.60688093649333e-05 20332243 Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death prostate cancer hsa-miR-143-3p AKT1 -1.04476349103257 1.5371074233558e-21 0.238590522807257 1.2055745906417e-06 miRNAWalker2_validate -0.131270403160778 4.83047520040954e-13 NA NA NA hsa-miR-409-3p AKT1 -0.0985105482626571 0.373607618015633 0.238590522807257 1.2055745906417e-06 PITA;miRNATAP -0.0753618659297608 7.52197621229397e-05 26631969 miR 409 3p suppresses breast cancer cell growth and invasion by targeting Akt1; Notably miR-409-3p induced downregulation of Akt1 protein through binding to its 3' untranslated region UTR; Conversely restoring Akt1 expression rescued the suppressive effects of miR-409-3p; Our data collectively indicate that miR-409-3p functions as a tumor suppressor in BC through downregulating Akt1 supporting the targeting of the novel miR-409-3p/Akt1 axis as a potentially effective therapeutic approach for BC breast cancer hsa-miR-204-5p AKT2 -1.00950273930717 9.21834560704471e-10 0.205981268081848 3.38171196942767e-07 mirMAP -0.0548958965114158 7.58477708021539e-08 NA NA NA hsa-miR-24-3p AKT2 -0.460804468884136 9.35756069405165e-09 0.205981268081848 3.38171196942767e-07 mirMAP -0.137465007182484 7.24062177017911e-11 NA NA NA hsa-miR-29a-3p AKT2 -0.164207050680213 0.0153192351779423 0.205981268081848 3.38171196942767e-07 MirTarget -0.0906543199244724 0.000443514490818085 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis acute myeloid leukemia hsa-miR-30e-3p AKT2 0.124356895579826 0.0750521491952429 0.205981268081848 3.38171196942767e-07 mirMAP -0.0603584575569103 0.0161711365927596 NA NA NA hsa-miR-330-5p AKT2 -0.493301557454585 1.71135028785136e-05 0.205981268081848 3.38171196942767e-07 miRanda -0.0579970855802833 0.000103892799424865 NA NA NA hsa-miR-106a-5p AKT3 1.76751200862602 7.79031604495348e-24 -0.187268246056622 0.0334600529001725 miRNATAP -0.097780438053709 1.4698058232989e-06 NA NA NA hsa-miR-106b-5p AKT3 1.03194006819592 5.97693261279744e-24 -0.187268246056622 0.0334600529001725 miRNATAP -0.13426688843128 0.000134869702518846 NA NA NA hsa-miR-140-5p AKT3 0.71404697529503 8.18104415848614e-20 -0.187268246056622 0.0334600529001725 miRanda -0.0990055793238344 0.034161000820928 NA NA NA hsa-miR-146b-5p AKT3 1.70281490248323 9.08060943822639e-35 -0.187268246056622 0.0334600529001725 miRNAWalker2_validate -0.150613813210278 1.92516559083097e-09 NA NA NA hsa-miR-15a-5p AKT3 0.922713188178758 6.51407511505232e-18 -0.187268246056622 0.0334600529001725 miRNAWalker2_validate;miRTarBase;miRNATAP -0.227967860616121 1.03456084304359e-11 NA NA NA hsa-miR-15b-5p AKT3 0.902378373341056 1.5233897847618e-20 -0.187268246056622 0.0334600529001725 miRNATAP -0.192686332598224 2.07479791432738e-07 NA NA NA hsa-miR-16-5p AKT3 0.54730888568038 1.14657883125954e-10 -0.187268246056622 0.0334600529001725 miRNAWalker2_validate;miRTarBase;miRNATAP -0.187792851597634 1.65516337670939e-05 NA NA NA hsa-miR-17-5p AKT3 1.75236465070226 3.95158641628068e-36 -0.187268246056622 0.0334600529001725 TargetScan;miRNATAP -0.111319013536562 8.39288594331358e-06 NA NA NA hsa-miR-181a-5p AKT3 0.3456964236223 0.000458417065949141 -0.187268246056622 0.0334600529001725 miRNATAP -0.1049153786986 0.00590255590184922 NA NA NA hsa-miR-20a-5p AKT3 1.8613782696103 3.92351368893256e-34 -0.187268246056622 0.0334600529001725 miRNATAP -0.099517249348377 1.41128517616254e-05 NA NA NA hsa-miR-20b-5p AKT3 1.58314196476132 5.61327965534646e-17 -0.187268246056622 0.0334600529001725 miRNATAP -0.0765377681426555 6.58193506421762e-05 NA NA NA hsa-miR-217 AKT3 0.647926571365963 0.000615546232893738 -0.187268246056622 0.0334600529001725 miRanda -0.0985687071258522 5.01269298224711e-07 NA NA NA hsa-miR-28-3p AKT3 0.464592918249577 2.99677077334997e-12 -0.187268246056622 0.0334600529001725 miRNATAP -0.177117313790308 0.00157489187389863 NA NA NA hsa-miR-29b-2-5p AKT3 0.789021480062024 2.59438538341201e-14 -0.187268246056622 0.0334600529001725 mirMAP -0.111484715576691 0.00167674228161345 NA NA NA hsa-miR-29b-3p AKT3 0.30584521532637 0.00477759838414942 -0.187268246056622 0.0334600529001725 miRNATAP -0.149314091165302 1.52771168258237e-05 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 1.04645334963496 3.19942342920484e-08 -0.187268246056622 0.0334600529001725 mirMAP -0.0606334469897386 0.00224213622150595 NA NA NA hsa-miR-320a AKT3 0.995486653328461 1.19389676663043e-20 -0.187268246056622 0.0334600529001725 PITA;miRanda;miRNATAP -0.167752649084532 6.47391286755109e-07 NA NA NA hsa-miR-335-3p AKT3 0.625191833097361 1.64208673352826e-06 -0.187268246056622 0.0334600529001725 mirMAP -0.0874393196465492 0.00219662833781205 NA NA NA hsa-miR-33a-3p AKT3 0.612459021907227 0.000347410219059137 -0.187268246056622 0.0334600529001725 mirMAP -0.0510061762914424 0.0225219579876133 NA NA NA hsa-miR-362-3p AKT3 0.332355427232084 0.0356765384646952 -0.187268246056622 0.0334600529001725 miRanda -0.0713413434540756 0.00296924083059947 NA NA NA hsa-miR-362-5p AKT3 1.31930944822897 5.90925525397455e-17 -0.187268246056622 0.0334600529001725 PITA;TargetScan;miRNATAP -0.148972025249129 5.69416781287202e-11 NA NA NA hsa-miR-501-3p AKT3 1.44481364651778 3.8180974374842e-26 -0.187268246056622 0.0334600529001725 miRNATAP -0.120402899495124 3.94389888929345e-06 NA NA NA hsa-miR-505-3p AKT3 -0.0131535015788877 0.895567778207462 -0.187268246056622 0.0334600529001725 mirMAP -0.146282366555392 9.96373619361454e-05 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-769-5p AKT3 0.49672539503154 5.04386163179354e-07 -0.187268246056622 0.0334600529001725 PITA;miRNATAP -0.083467925522967 0.0274415398007013 NA NA NA hsa-miR-93-5p AKT3 2.02673564951392 4.11722430511325e-49 -0.187268246056622 0.0334600529001725 miRNATAP -0.150123402144443 9.21250792584763e-10 NA NA NA hsa-miR-339-5p APAF1 0.986556478524229 2.39294233177816e-12 -0.0920814938150381 0.179718615542637 miRanda -0.0926297985455634 4.57017822773987e-06 NA NA NA hsa-miR-374b-5p APAF1 0.221226738167834 0.00747242957932175 -0.0920814938150381 0.179718615542637 mirMAP -0.0972139911898869 0.00626279429856325 NA NA NA hsa-miR-664a-3p APAF1 0.771665734879281 3.09460128204919e-14 -0.0920814938150381 0.179718615542637 mirMAP -0.101099973578795 0.00031978684124289 NA NA NA hsa-miR-186-5p ATM 0.567811924899218 1.37607142180899e-13 -0.24425360585469 0.0109417346392699 mirMAP -0.156287974230106 0.00301746495438531 NA NA NA hsa-miR-18a-5p ATM 1.25716708436839 5.17098086128653e-16 -0.24425360585469 0.0109417346392699 miRNAWalker2_validate;miRTarBase;MirTarget -0.174414720572328 4.97059923577194e-12 23437304;25963391;23857602;23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression colorectal cancer;cervical and endocervical cancer;breast cancer;colon cancer hsa-miR-199b-5p ATM 1.17761875205879 1.049059589835e-17 -0.24425360585469 0.0109417346392699 miRanda -0.108267856399836 0.000173217429421883 NA NA NA hsa-miR-19b-3p ATM 1.59390221063917 1.21812878827888e-26 -0.24425360585469 0.0109417346392699 miRNAWalker2_validate -0.175029973293992 9.46689820135909e-12 NA NA NA hsa-miR-217 ATM 0.647926571365963 0.000615546232893738 -0.24425360585469 0.0109417346392699 miRanda -0.0805768076826108 0.000180114302457686 NA NA NA hsa-miR-26b-5p ATM 0.737437044119261 6.43607077095392e-18 -0.24425360585469 0.0109417346392699 MirTarget -0.19452121423322 2.94630398503719e-05 NA NA NA hsa-miR-29a-5p ATM 0.458517912323329 0.000412683536074969 -0.24425360585469 0.0109417346392699 mirMAP -0.113899090581866 0.000286998855047873 NA NA NA hsa-miR-30b-5p ATM 1.16764575603669 1.75395013539888e-20 -0.24425360585469 0.0109417346392699 mirMAP -0.206694534732418 2.22257344532093e-11 25202329 However specific miRNAs are downregulated in ATC such as those of the miR-200 and miR-30 families which are important negative regulators of cell migration invasion and epithelial-to-mesenchymal transition EMT processes that are overactivated in ATC cell migration thyroid cancer hsa-miR-30c-5p ATM 0.746747513281495 1.32431877874944e-12 -0.24425360585469 0.0109417346392699 mirMAP -0.280493816935332 6.55181106553326e-14 NA NA NA hsa-miR-324-5p ATM 0.539970285576227 1.69955273262765e-05 -0.24425360585469 0.0109417346392699 miRanda -0.185560139241443 7.4377324160098e-09 NA NA NA hsa-miR-339-5p ATM 0.986556478524229 2.39294233177816e-12 -0.24425360585469 0.0109417346392699 miRanda -0.192659899020989 6.27367337051501e-12 NA NA NA hsa-miR-362-3p ATM 0.332355427232084 0.0356765384646952 -0.24425360585469 0.0109417346392699 miRanda -0.0565415677868138 0.0312856217439519 NA NA NA hsa-miR-374b-5p ATM 0.221226738167834 0.00747242957932175 -0.24425360585469 0.0109417346392699 mirMAP -0.155764282022554 0.00178568639124228 NA NA NA hsa-miR-500a-5p ATM 0.724031963091637 1.07520204401533e-07 -0.24425360585469 0.0109417346392699 mirMAP -0.144517213460166 1.0822230515859e-06 NA NA NA hsa-miR-576-5p ATM 0.962105441345164 5.68435745070738e-14 -0.24425360585469 0.0109417346392699 mirMAP -0.0734490912283901 0.0190667656391716 NA NA NA hsa-miR-590-3p ATM 0.58484153433625 1.6489232844135e-06 -0.24425360585469 0.0109417346392699 miRanda;mirMAP -0.0786030319767326 0.0187960441795781 NA NA NA hsa-miR-590-5p ATM 0.778106902153171 1.13576371947662e-09 -0.24425360585469 0.0109417346392699 mirMAP -0.0949619792476294 0.00266739116362452 NA NA NA hsa-miR-92a-3p ATM 1.46190744132999 3.47140194919364e-41 -0.24425360585469 0.0109417346392699 miRNAWalker2_validate -0.140642316816484 5.30464126882324e-05 NA NA NA hsa-miR-127-3p BAD -0.560886369493673 1.32314192360344e-07 0.305950856552611 0.000765878425548941 miRanda;miRNATAP -0.239712065709148 1.9111717497803e-11 NA NA NA hsa-miR-326 BAD -0.893385784609658 5.72581663211179e-08 0.305950856552611 0.000765878425548941 miRanda -0.138149495409081 2.74707996249775e-09 NA NA NA hsa-miR-330-5p BAD -0.493301557454585 1.71135028785136e-05 0.305950856552611 0.000765878425548941 miRNAWalker2_validate;miRanda -0.229895206210211 4.07625500377545e-12 NA NA NA hsa-miR-125a-3p BAX -0.335450161542356 0.00400908432417966 0.61750168964206 6.17527108431874e-14 miRanda -0.158794206339722 3.12050477221821e-07 NA NA NA hsa-miR-133b BAX -1.6405074687617 4.27792135252392e-19 0.61750168964206 6.17527108431874e-14 miRanda -0.127145724267346 7.94758024867071e-12 NA NA NA hsa-let-7a-5p BCL2 0.810823676990504 1.01381033479571e-26 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate -0.588832651693555 5.17651889478562e-14 24643702;26915294 Estrogen combined with progesterone decreases cell proliferation and inhibits the expression of Bcl 2 via microRNA let 7a and miR 34b in ovarian cancer cells; Moreover the relative abundance of Bcl-2 and microRNAs let-7a miR-34b expressions were detected by quantitative real-time PCR qRT-PCR and Western blotting; E2 + P4 promoted the expression of let-7a and miR-34b and reduced the expression of Bcl-2 in ovarian cancer cells; When the expression of let-7a or/and miR-34b was inhibited using miRNA inhibitors E2 + P4 treatment did not change the protein level of Bcl-2; E2 + P4 significantly inhibited the cell survival promoted the cell apoptosis induced the expression of let-7a and miR-34b and reduced the expression of Bcl-2 in ovarian cancer cells;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively poor survival;poor survival ovarian cancer;lung cancer hsa-miR-103a-3p BCL2 1.20954748107198 5.62173682108416e-44 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate -0.43841129898594 3.04953303078691e-11 NA NA NA hsa-miR-126-5p BCL2 0.222731872217002 0.050097821552168 -1.20400501263257 4.51412820200345e-17 mirMAP -0.199221382501941 0.000330700661096105 NA NA NA hsa-miR-130b-5p BCL2 1.15237450600836 1.61871514364343e-14 -1.20400501263257 4.51412820200345e-17 mirMAP -0.288613046260257 6.71782109403444e-13 27364335 The level of microRNA-130b in relationship with the expression of PPARγ VEGF-A BCL-2 and apoptosis were analyzed in 91 lung cancer patient samples using immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL assay on tissue microarrays; In vitro and in vivo miR-130b enrichment associated with down-regulation of PPARγ up-regulation of VEGF-A and BCL-2 and decreased apoptosis lung cancer hsa-miR-140-3p BCL2 0.589055604093293 1.70551761364546e-15 -1.20400501263257 4.51412820200345e-17 PITA -0.364682394646659 1.24589885163498e-05 NA NA NA hsa-miR-148a-3p BCL2 1.85007671007711 2.47199960189831e-52 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate;miRTarBase -0.383024712476222 5.15494161232474e-17 21455217;23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a ; colorectal cancer;pancreatic cancer hsa-miR-153-3p BCL2 2.47515671687691 7.20564234459074e-37 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate;miRTarBase -0.355213266311162 3.58556686641767e-34 19676043;21213215 Bioinformatics analysis revealed that anti-apoptosis family member B-cell lymphoma 2 Bcl-2 and myeloid cell leukemia sequence 1 Mcl-1 are potential targets of miR-153; Indeed Western blot analysis indicated that miR-153 downregulated both Bcl-2 and Mcl-1 at the protein levels; By luciferase reporter assays we further showed that miR-153 inhibited Bcl-2 and Mcl-1 expressions by directly targeting the 3'UTR regions of their respective mRNAs;Previously we established that microRNA-153 miR-153 induces apoptosis by downregulating B-cell lymphoma 2 Bcl-2 and myeloid cell leukemia sequence 1 Mcl-1 protein expression levels in glioblastoma cell line DBTRG-05MG ; B cell lymphoma;glioblastoma hsa-miR-15a-5p BCL2 0.922713188178758 6.51407511505232e-18 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate;miRTarBase -0.218919456078264 0.000126077993786931 18931683;25594541;26915294;25623762;22335947 MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 ;;poor survival;drug resistance; prostate cancer;breast cancer;lung cancer;colon cancer;breast cancer hsa-miR-15b-3p BCL2 0.70449098511926 1.79992266779526e-09 -1.20400501263257 4.51412820200345e-17 mirMAP -0.33386631849144 1.85607161497749e-10 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-15b-5p BCL2 0.902378373341056 1.5233897847618e-20 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate;miRTarBase -0.454161894926691 1.58647261204961e-13 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-16-1-3p BCL2 0.6666012357419 1.32179543917662e-06 -1.20400501263257 4.51412820200345e-17 mirMAP -0.0976526683572088 0.033219496609113 18931683 MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2 prostate cancer hsa-miR-17-5p BCL2 1.75236465070226 3.95158641628068e-36 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate;miRTarBase -0.345211495304172 3.78039023431673e-17 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-182-5p BCL2 2.57717136150548 4.94377928075077e-59 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate;miRTarBase;mirMAP -0.339377162120366 1.50544264257053e-23 23936432;26870290 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR 182 and p21; Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells;The expression levels of B-cell lymphoma-2 Bcl-2 and microRNA-182 miR-182 were detected using western blot analysis and quantitative reverse transcription-polymerase chain reaction respectively; Mangiferin treatment was also able to significantly reduce Bcl-2 expression levels and enhance miR-182 expression in PC3 cells; Finally it was observed that mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182 ; prostate cancer;B cell lymphoma hsa-miR-186-5p BCL2 0.567811924899218 1.37607142180899e-13 -1.20400501263257 4.51412820200345e-17 mirMAP -0.490153788523526 9.07700687274071e-10 NA NA NA hsa-miR-195-3p BCL2 0.598450619600341 1.01415597921415e-08 -1.20400501263257 4.51412820200345e-17 mirMAP -0.11991656262293 0.0455381413291363 20727858;26632252;23760062;26309570 Moreover important antiapoptotic Bcl-2 was identified to be directly targeted by miR-195 and miR-195 was further suggested to exert its proapoptotic function mainly through targeting Bcl-2 expression;Previously we demonstrated that hsa-miR-195 targets BCL2 induces apoptosis and augmented the effect of etoposide in breast cancer cells;Moreover knockdown of Raf-1 expression had similar effects of miR-195 mimics on breast cancer cells both of which were able to suppress Bcl-2 and P-glycoprotein expression in breast cancer cells;Upregulation of miR 195 enhances the radiosensitivity of breast cancer cells through the inhibition of BCL 2; Exogenetic miR-195 expression could significantly enhance the radiosensitivity of human breast cancer cells; this finding may be attributed to BCL-2 downregulation to promote radiation-induced apoptosis ;;; colorectal cancer;breast cancer;breast cancer;breast cancer hsa-miR-196b-5p BCL2 0.805107318355033 4.71253050668929e-11 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate -0.333721228882832 2.19521191106759e-11 NA NA NA hsa-miR-200c-3p BCL2 2.0381485757767 1.11482598742501e-54 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate;miRTarBase;mirMAP -0.396089312943526 2.88714614118083e-21 NA NA NA hsa-miR-20a-3p BCL2 1.93545996942606 5.86749215003338e-31 -1.20400501263257 4.51412820200345e-17 mirMAP -0.279835050327442 6.36232167727941e-16 NA NA NA hsa-miR-20a-5p BCL2 1.8613782696103 3.92351368893256e-34 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate;miRTarBase -0.308936211764971 2.29679953926233e-16 NA NA NA hsa-miR-21-5p BCL2 1.03478217459822 8.05139001473458e-27 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate;miRTarBase -0.2820672124691 5.55938996170985e-06 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-29a-5p BCL2 0.458517912323329 0.000412683536074969 -1.20400501263257 4.51412820200345e-17 mirMAP -0.120000668262784 0.0133162236245181 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29b-3p BCL2 0.30584521532637 0.00477759838414942 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate;miRTarBase -0.127327529564382 0.0291024386073574 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-3065-5p BCL2 1.04645334963496 3.19942342920484e-08 -1.20400501263257 4.51412820200345e-17 mirMAP -0.136451171575312 3.96083413615833e-05 NA NA NA hsa-miR-30a-3p BCL2 -0.0513578942843527 0.646614247659816 -1.20400501263257 4.51412820200345e-17 mirMAP -0.141290269196176 0.0125473381777042 26472042 Overexpression of miR-30a and miR-934 in normal and HNSCC cell lines produced up to a 2-fold increase in cellular proliferation as well as induction of the anti-apoptotic gene BCL-2 head and neck cancer hsa-miR-30d-3p BCL2 0.917692758870644 7.72239658481305e-16 -1.20400501263257 4.51412820200345e-17 mirMAP -0.288993805515749 6.52917223340934e-08 NA NA NA hsa-miR-33a-5p BCL2 -0.0191758999894391 0.924819190352805 -1.20400501263257 4.51412820200345e-17 mirMAP -0.117889943441977 0.000138694124868228 NA NA NA hsa-miR-342-3p BCL2 1.25856075011434 9.50396545654544e-34 -1.20400501263257 4.51412820200345e-17 miRanda -0.255668146099949 6.76211917721547e-06 NA NA NA hsa-miR-365a-3p BCL2 0.549429463477979 3.33080608258095e-07 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate;miRTarBase -0.170697707547036 0.00334096795121977 NA NA NA hsa-miR-375 BCL2 3.0764157413036 1.01411669962466e-67 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate -0.376701413600904 2.68862032057592e-38 26381132;26697569;25613180 The levels of miR-375 Bax and Bcl-2 protein expression in treated cells were determined by Western blot and RT-PCR; Moreover compared to control group the expression of Bcl-2 and miR-375 decreases with formononetin in the U2OS cells while Bax increases;Exosome Carried microRNA 375 Inhibits Cell Progression and Dissemination via Bcl 2 Blocking in Colon Cancer; RT-PCR for Bcl-2 expression showed that Bcl-2 is down-regulated for miR-375 inhibitor and up-regulated for the miR-375 mimic a result confirmed by Western blotting; The present study brings to the forefront new data that suggest miR-375 as a new player in controlling the pathways responsible for inhibiting the natural history of CRC tumor cells via the Bcl-2 pathway;mRNA levels of ERα Bcl-2 and miR-375 were quantified using real-time polymerase chain reaction; After treatment with biochanin A ERα miR-375 and Bcl-2 expression was significantly upregulated ;progression; sarcoma;colon cancer;breast cancer hsa-miR-582-5p BCL2 0.306116891157887 0.0402663500947974 -1.20400501263257 4.51412820200345e-17 PITA -0.24226083616041 6.52403436823341e-09 NA NA NA hsa-miR-590-3p BCL2 0.58484153433625 1.6489232844135e-06 -1.20400501263257 4.51412820200345e-17 miRanda;mirMAP -0.222012348917327 1.43071096372657e-05 NA NA NA hsa-miR-590-5p BCL2 0.778106902153171 1.13576371947662e-09 -1.20400501263257 4.51412820200345e-17 miRanda -0.219154873603807 5.93684065251851e-06 NA NA NA hsa-miR-629-5p BCL2 1.11274734579886 7.79513509275689e-24 -1.20400501263257 4.51412820200345e-17 mirMAP -0.428995530274087 9.61051165967554e-16 NA NA NA hsa-miR-664a-3p BCL2 0.771665734879281 3.09460128204919e-14 -1.20400501263257 4.51412820200345e-17 mirMAP -0.38628371533804 1.12099877761181e-10 NA NA NA hsa-miR-664a-5p BCL2 1.01933673664319 5.07855762632389e-20 -1.20400501263257 4.51412820200345e-17 mirMAP -0.267176003943994 9.12997885688893e-07 NA NA NA hsa-miR-7-1-3p BCL2 1.45703750327525 1.75378847810395e-30 -1.20400501263257 4.51412820200345e-17 mirMAP -0.418218314570521 2.90379565464916e-20 NA NA NA hsa-miR-96-5p BCL2 2.57339472553563 5.77311209747788e-53 -1.20400501263257 4.51412820200345e-17 miRNAWalker2_validate;TargetScan -0.349273480004752 2.51025998268364e-27 NA NA NA hsa-let-7e-5p BCL2L1 0.438407722828892 6.33224012337318e-08 0.250269260273239 5.65287053118972e-07 miRNATAP -0.0676889263559709 0.0103887005686874 NA NA NA hsa-miR-23b-3p BCL2L1 -0.601466385152159 1.26793373995413e-12 0.250269260273239 5.65287053118972e-07 miRNAWalker2_validate -0.0906022604187896 0.000276627760393064 NA NA NA hsa-miR-330-5p BCL2L1 -0.493301557454585 1.71135028785136e-05 0.250269260273239 5.65287053118972e-07 PITA;miRanda;miRNATAP -0.0686394281643089 0.000219063156041567 NA NA NA hsa-miR-338-5p BID -1.02227005954571 1.23429740086589e-09 0.294631201762007 3.62685491463565e-06 MirTarget -0.0660841402005166 3.72673478520114e-05 NA NA NA hsa-miR-370-3p BID -0.170475152284462 0.227983942027623 0.294631201762007 3.62685491463565e-06 MirTarget -0.0900620284623301 3.46860028014555e-06 NA NA NA hsa-miR-204-5p BIRC2 -1.00950273930717 9.21834560704471e-10 -0.0473529835468423 0.385989568920629 miRNAWalker2_validate;miRTarBase;MirTarget -0.0561715936056456 4.58718398973703e-05 NA NA NA hsa-miR-29a-3p BIRC2 -0.164207050680213 0.0153192351779423 -0.0473529835468423 0.385989568920629 MirTarget -0.085904690676839 0.0134072499388472 NA NA NA hsa-miR-29b-3p BIRC2 0.30584521532637 0.00477759838414942 -0.0473529835468423 0.385989568920629 MirTarget -0.0990463462499296 3.26892426269852e-06 NA NA NA hsa-miR-29c-3p BIRC2 -0.0707692065669665 0.397653135713718 -0.0473529835468423 0.385989568920629 MirTarget -0.0726409147944492 0.00946664771190157 NA NA NA hsa-miR-500a-5p BIRC2 0.724031963091637 1.07520204401533e-07 -0.0473529835468423 0.385989568920629 MirTarget -0.0561695722694631 0.000865813486332576 NA NA NA hsa-miR-20b-3p BIRC3 1.2034103534124 8.32665871015935e-10 -0.333347040597571 0.0218505250015214 MirTarget -0.132903090299146 1.79742615964023e-05 NA NA NA hsa-miR-26b-5p BIRC3 0.737437044119261 6.43607077095392e-18 -0.333347040597571 0.0218505250015214 mirMAP -0.280773778244019 6.97290310081975e-05 NA NA NA hsa-miR-375 BIRC3 3.0764157413036 1.01411669962466e-67 -0.333347040597571 0.0218505250015214 miRNAWalker2_validate -0.228481864925861 3.14904755315378e-14 23726271 Taken together these data suggest that miR-375 sensitizes TNF-α-induced apoptosis and the reduction in the expression of the apoptosis inhibitory proteins cFLIP-L and cIAP2 plays an important role in this sensitization head and neck cancer hsa-miR-590-3p BIRC3 0.58484153433625 1.6489232844135e-06 -0.333347040597571 0.0218505250015214 miRanda;mirMAP -0.105987384370162 0.0366122652962342 NA NA NA hsa-miR-651-5p BIRC3 1.07302155809615 3.23248309719665e-12 -0.333347040597571 0.0218505250015214 MirTarget -0.184757937417561 4.10413108316155e-06 NA NA NA hsa-miR-664a-3p BIRC3 0.771665734879281 3.09460128204919e-14 -0.333347040597571 0.0218505250015214 mirMAP -0.207951615434657 0.00050244293128048 NA NA NA hsa-miR-140-5p CAPN1 0.71404697529503 8.18104415848614e-20 -0.292689525965144 4.93540984999702e-09 miRanda;miRNATAP -0.130755647204678 8.66977943767516e-07 NA NA NA hsa-miR-1468-5p CAPN2 0.469053143305544 5.66395086652441e-05 -0.139275480490237 0.100218797660395 MirTarget -0.0708772929017203 0.0218959045759036 NA NA NA hsa-miR-20a-3p CAPN2 1.93545996942606 5.86749215003338e-31 -0.139275480490237 0.100218797660395 MirTarget -0.0653585046311982 0.00129740537221732 NA NA NA hsa-miR-30a-5p CAPN2 0.50856224391991 3.02321261664547e-06 -0.139275480490237 0.100218797660395 miRNAWalker2_validate -0.0818017095729085 0.0131923393202272 NA NA NA hsa-miR-33a-3p CAPN2 0.612459021907227 0.000347410219059137 -0.139275480490237 0.100218797660395 mirMAP -0.0553847434345131 0.00990689391117263 NA NA NA hsa-miR-590-3p CAPN2 0.58484153433625 1.6489232844135e-06 -0.139275480490237 0.100218797660395 miRanda -0.0689938410610842 0.0192062002740915 NA NA NA hsa-miR-590-5p CAPN2 0.778106902153171 1.13576371947662e-09 -0.139275480490237 0.100218797660395 miRanda -0.0577783412762527 0.038407534280326 NA NA NA hsa-miR-125a-5p CASP10 0.0743450557019028 0.423845877863837 -0.406341640506477 0.0029821176967154 mirMAP -0.168416540114261 0.00795787205438673 NA NA NA hsa-miR-186-5p CASP10 0.567811924899218 1.37607142180899e-13 -0.406341640506477 0.0029821176967154 MirTarget;mirMAP -0.241951340977421 0.0012937725368632 NA NA NA hsa-miR-19a-3p CASP10 1.31708679186777 4.80964007387826e-14 -0.406341640506477 0.0029821176967154 MirTarget;mirMAP -0.133761633736158 3.92686207249134e-05 NA NA NA hsa-miR-19b-1-5p CASP10 1.2422681534557 6.2822395141178e-20 -0.406341640506477 0.0029821176967154 mirMAP -0.211668017521019 2.81739251468312e-07 NA NA NA hsa-miR-19b-3p CASP10 1.59390221063917 1.21812878827888e-26 -0.406341640506477 0.0029821176967154 MirTarget;mirMAP -0.230358685086392 3.87266608142065e-10 NA NA NA hsa-miR-200c-3p CASP10 2.0381485757767 1.11482598742501e-54 -0.406341640506477 0.0029821176967154 mirMAP -0.30015063486395 2.5275662428976e-14 NA NA NA hsa-miR-26b-5p CASP10 0.737437044119261 6.43607077095392e-18 -0.406341640506477 0.0029821176967154 mirMAP -0.283082209648739 2.06060242288221e-05 NA NA NA hsa-miR-30b-3p CASP10 1.1693697068827 7.84594435698899e-16 -0.406341640506477 0.0029821176967154 MirTarget -0.193379075688912 6.97252846847961e-07 NA NA NA hsa-miR-320a CASP10 0.995486653328461 1.19389676663043e-20 -0.406341640506477 0.0029821176967154 miRanda -0.114369218276401 0.0310109707155287 NA NA NA hsa-miR-338-3p CASP10 0.289775600192432 0.0820821857540425 -0.406341640506477 0.0029821176967154 miRanda -0.0833367832628864 0.0177187447315791 NA NA NA hsa-miR-33a-3p CASP10 0.612459021907227 0.000347410219059137 -0.406341640506477 0.0029821176967154 mirMAP -0.156791190334921 5.85959944794299e-06 NA NA NA hsa-miR-361-5p CASP10 0.65220098099292 2.23302456529998e-21 -0.406341640506477 0.0029821176967154 miRanda -0.231934325596817 0.00522175956958738 NA NA NA hsa-miR-374a-3p CASP10 0.613148065516 1.92239481728524e-11 -0.406341640506477 0.0029821176967154 mirMAP -0.150908578065506 0.0171811180086318 NA NA NA hsa-miR-532-5p CASP10 0.819279743754755 7.86212163153492e-15 -0.406341640506477 0.0029821176967154 mirMAP -0.167392086708939 0.0020354318229245 NA NA NA hsa-miR-744-3p CASP10 0.724560065349017 7.6652821115792e-07 -0.406341640506477 0.0029821176967154 mirMAP -0.243165706544977 4.5683180201092e-10 NA NA NA hsa-let-7c-5p CASP3 0.0545238982989691 0.57403395273379 0.0406469320959024 0.441563879584736 MirTarget -0.0849936112496863 0.000249026302049031 NA NA NA hsa-miR-139-5p CASP3 -0.248477989074291 0.0406493945332495 0.0406469320959024 0.441563879584736 miRanda -0.131875293210689 3.36747112976266e-13 NA NA NA hsa-miR-221-3p CASP3 -1.24494692780126 3.24056780178261e-20 0.0406469320959024 0.441563879584736 miRNAWalker2_validate -0.102901768653808 6.31424833045737e-11 NA NA NA hsa-miR-28-5p CASP3 0.142043455520843 0.0231808012790841 0.0406469320959024 0.441563879584736 miRanda -0.0846971046450299 0.020288847562402 NA NA NA hsa-miR-30a-5p CASP3 0.50856224391991 3.02321261664547e-06 0.0406469320959024 0.441563879584736 miRNATAP -0.147826276108511 1.64067286487355e-13 NA NA NA hsa-miR-30c-5p CASP3 0.746747513281495 1.32431877874944e-12 0.0406469320959024 0.441563879584736 miRNATAP -0.108088388169846 1.84681917447047e-07 NA NA NA hsa-miR-374a-5p CASP3 -0.0315285733368942 0.724846989131108 0.0406469320959024 0.441563879584736 mirMAP -0.0764352494475273 0.00243509190007906 NA NA NA hsa-miR-374b-5p CASP3 0.221226738167834 0.00747242957932175 0.0406469320959024 0.441563879584736 mirMAP -0.118541464645823 1.26359423516914e-05 NA NA NA hsa-miR-125a-3p CASP6 -0.335450161542356 0.00400908432417966 0.127968233316692 0.0369374434926149 miRanda -0.0886859033327049 9.1345572569951e-05 NA NA NA hsa-miR-125a-5p CASP6 0.0743450557019028 0.423845877863837 0.127968233316692 0.0369374434926149 miRanda -0.0829418239859878 0.00335811168089567 NA NA NA hsa-miR-129-5p CASP6 -0.664119897121714 0.00207371121658161 0.127968233316692 0.0369374434926149 MirTarget;miRanda -0.0557515847394535 7.29917694749901e-06 NA NA NA hsa-miR-129-5p CASP7 -0.664119897121714 0.00207371121658161 0.254207615243397 0.0063088684191005 miRanda -0.0903496233033173 1.76924129108254e-06 NA NA NA hsa-miR-320a CASP7 0.995486653328461 1.19389676663043e-20 0.254207615243397 0.0063088684191005 miRanda -0.120878270203945 0.000759999503051587 NA NA NA hsa-miR-320b CASP7 0.588484324371412 9.31703617590329e-06 0.254207615243397 0.0063088684191005 miRanda -0.0982326771269926 0.000968764155643626 NA NA NA hsa-miR-484 CASP7 0.968911692345786 2.45789986401578e-17 0.254207615243397 0.0063088684191005 miRNAWalker2_validate -0.0690933075604035 0.0411735411620909 NA NA NA hsa-miR-143-3p CASP8 -1.04476349103257 1.5371074233558e-21 0.28497735817093 0.000684507839747487 MirTarget -0.0827798596314252 0.00880447671884208 NA NA NA hsa-miR-26b-5p CASP8 0.737437044119261 6.43607077095392e-18 0.28497735817093 0.000684507839747487 miRNAWalker2_validate -0.108738105099786 0.00796632977997113 NA NA NA hsa-miR-455-5p CASP8 -0.485855374388109 0.000213721591485816 0.28497735817093 0.000684507839747487 miRanda -0.125846690887638 3.46901547034654e-06 NA NA NA hsa-miR-542-3p CASP8 -0.318649418920791 0.0301489241026751 0.28497735817093 0.000684507839747487 miRanda -0.0791445887628771 0.00117320374455893 NA NA NA hsa-miR-195-5p CASP9 0.168349197829253 0.0556817031396093 0.0143332098000206 0.749128481098228 mirMAP -0.0873314999102352 5.43699413704505e-05 NA NA NA hsa-miR-125a-5p CFLAR 0.0743450557019028 0.423845877863837 -0.125175934929148 0.0765297414492897 miRanda -0.0719098355562132 0.0276600680448464 NA NA NA hsa-miR-130a-3p CFLAR -0.00961131533334481 0.934528436621983 -0.125175934929148 0.0765297414492897 mirMAP -0.0572673032522645 0.0267808331117486 NA NA NA hsa-miR-15b-5p CFLAR 0.902378373341056 1.5233897847618e-20 -0.125175934929148 0.0765297414492897 mirMAP -0.0792323615124658 0.00827381297393447 NA NA NA hsa-miR-16-5p CFLAR 0.54730888568038 1.14657883125954e-10 -0.125175934929148 0.0765297414492897 mirMAP -0.0762509540230089 0.0300896415670568 NA NA NA hsa-miR-186-5p CFLAR 0.567811924899218 1.37607142180899e-13 -0.125175934929148 0.0765297414492897 mirMAP -0.0949648636159458 0.0142203180266848 NA NA NA hsa-miR-199b-5p CFLAR 1.17761875205879 1.049059589835e-17 -0.125175934929148 0.0765297414492897 mirMAP -0.0602796885395992 0.00451190532533094 NA NA NA hsa-miR-301a-3p CFLAR 0.501721475120081 0.000262747397142618 -0.125175934929148 0.0765297414492897 mirMAP -0.0524502506900629 0.0163667810800158 NA NA NA hsa-miR-30b-3p CFLAR 1.1693697068827 7.84594435698899e-16 -0.125175934929148 0.0765297414492897 mirMAP -0.0504758727163218 0.0124725896442141 NA NA NA hsa-miR-30c-2-3p CFLAR 0.286703129021101 0.00883485020840932 -0.125175934929148 0.0765297414492897 mirMAP -0.0784078143862597 0.00439324049176753 NA NA NA hsa-miR-320a CFLAR 0.995486653328461 1.19389676663043e-20 -0.125175934929148 0.0765297414492897 miRanda -0.131432904590659 1.14984179593234e-06 NA NA NA hsa-miR-338-3p CFLAR 0.289775600192432 0.0820821857540425 -0.125175934929148 0.0765297414492897 miRanda;mirMAP -0.0757721158691378 2.46581316619394e-05 NA NA NA hsa-miR-339-5p CFLAR 0.986556478524229 2.39294233177816e-12 -0.125175934929148 0.0765297414492897 miRanda -0.0608321443295701 0.00368155351307387 NA NA NA hsa-miR-374b-5p CFLAR 0.221226738167834 0.00747242957932175 -0.125175934929148 0.0765297414492897 MirTarget -0.129134028568934 0.000412685229034942 NA NA NA hsa-miR-454-3p CFLAR 1.05348676011504 1.08188735671639e-16 -0.125175934929148 0.0765297414492897 mirMAP -0.0852036498515146 0.000211402416213369 NA NA NA hsa-miR-484 CFLAR 0.968911692345786 2.45789986401578e-17 -0.125175934929148 0.0765297414492897 mirMAP -0.0528713404907461 0.038990784605473 NA NA NA hsa-miR-497-5p CFLAR 0.424937624679998 8.43432731476407e-05 -0.125175934929148 0.0765297414492897 mirMAP -0.0630054569472282 0.0235313056204655 NA NA NA hsa-miR-660-5p CFLAR 1.14400353328339 2.69534153134519e-19 -0.125175934929148 0.0765297414492897 mirMAP -0.068294043440058 0.00277986303119219 NA NA NA hsa-miR-106a-5p CHP2 1.76751200862602 7.79031604495348e-24 -3.07023460493225 4.49088124754345e-17 MirTarget -0.461014183135841 1.08838979102806e-07 NA NA NA hsa-miR-106b-5p CHP2 1.03194006819592 5.97693261279744e-24 -3.07023460493225 4.49088124754345e-17 MirTarget -1.43757741469298 3.86456190773472e-23 NA NA NA hsa-miR-17-5p CHP2 1.75236465070226 3.95158641628068e-36 -3.07023460493225 4.49088124754345e-17 MirTarget -0.932018353240091 3.66657181328124e-19 NA NA NA hsa-miR-20a-5p CHP2 1.8613782696103 3.92351368893256e-34 -3.07023460493225 4.49088124754345e-17 MirTarget -0.781921528845299 4.07925384326293e-16 NA NA NA hsa-miR-20b-5p CHP2 1.58314196476132 5.61327965534646e-17 -3.07023460493225 4.49088124754345e-17 MirTarget -0.41226779790291 4.67066538440571e-07 NA NA NA hsa-miR-339-5p CHP2 0.986556478524229 2.39294233177816e-12 -3.07023460493225 4.49088124754345e-17 miRanda -0.605943404615592 4.67771742559095e-08 NA NA NA hsa-miR-501-3p CHP2 1.44481364651778 3.8180974374842e-26 -3.07023460493225 4.49088124754345e-17 miRNATAP -0.88801403088216 5.26556585465604e-16 NA NA NA hsa-miR-502-3p CHP2 0.269247655104258 0.011082474452809 -3.07023460493225 4.49088124754345e-17 miRNATAP -0.454225453165332 0.00282222318106982 NA NA NA hsa-miR-93-5p CHP2 2.02673564951392 4.11722430511325e-49 -3.07023460493225 4.49088124754345e-17 MirTarget -1.07906700496017 2.2548979389439e-26 NA NA NA hsa-miR-15a-5p CHUK 0.922713188178758 6.51407511505232e-18 -0.0922497309080645 0.138442424117139 miRNAWalker2_validate;miRTarBase;MirTarget -0.133191432381788 2.15605034669508e-08 NA NA NA hsa-miR-16-5p CHUK 0.54730888568038 1.14657883125954e-10 -0.0922497309080645 0.138442424117139 miRNAWalker2_validate;miRTarBase;MirTarget -0.146339633924948 1.84135672503988e-06 NA NA NA hsa-miR-195-5p CHUK 0.168349197829253 0.0556817031396093 -0.0922497309080645 0.138442424117139 miRNAWalker2_validate;MirTarget -0.0948812767618329 0.00172911396974957 NA NA NA hsa-miR-29b-2-5p CHUK 0.789021480062024 2.59438538341201e-14 -0.0922497309080645 0.138442424117139 MirTarget -0.0661644804981416 0.00824544176407014 NA NA NA hsa-miR-339-5p CHUK 0.986556478524229 2.39294233177816e-12 -0.0922497309080645 0.138442424117139 miRanda -0.12450456937824 6.14084735917345e-12 NA NA NA hsa-miR-342-3p CHUK 1.25856075011434 9.50396545654544e-34 -0.0922497309080645 0.138442424117139 miRanda -0.0996319386162951 3.00815488524408e-05 NA NA NA hsa-miR-376c-3p CHUK -0.121213663149107 0.38337710741772 -0.0922497309080645 0.138442424117139 MirTarget -0.118988597135934 4.02504128813333e-10 NA NA NA hsa-miR-497-5p CHUK 0.424937624679998 8.43432731476407e-05 -0.0922497309080645 0.138442424117139 MirTarget -0.131864946530957 5.10068963365684e-08 NA NA NA hsa-miR-590-3p CHUK 0.58484153433625 1.6489232844135e-06 -0.0922497309080645 0.138442424117139 miRanda;mirMAP -0.0704829089018411 0.00107827886402182 NA NA NA hsa-miR-590-5p CHUK 0.778106902153171 1.13576371947662e-09 -0.0922497309080645 0.138442424117139 miRanda -0.0722364925923532 0.000395820121710205 NA NA NA hsa-miR-655-3p CHUK 0.547567790590952 0.00016735577074255 -0.0922497309080645 0.138442424117139 MirTarget -0.0955924601868035 1.56988832226945e-07 NA NA NA hsa-miR-186-5p CSF2RB 0.567811924899218 1.37607142180899e-13 0.0350805584150806 0.838402939094343 mirMAP -0.289972176057264 0.00208725490894989 NA NA NA hsa-miR-19a-3p CSF2RB 1.31708679186777 4.80964007387826e-14 0.0350805584150806 0.838402939094343 MirTarget -0.159484942184595 9.17217838982353e-05 NA NA NA hsa-miR-19b-3p CSF2RB 1.59390221063917 1.21812878827888e-26 0.0350805584150806 0.838402939094343 MirTarget -0.288979291396846 3.61692318874733e-10 NA NA NA hsa-miR-30b-3p CSF2RB 1.1693697068827 7.84594435698899e-16 0.0350805584150806 0.838402939094343 MirTarget -0.326895215321167 1.35915104418209e-11 NA NA NA hsa-miR-576-5p CSF2RB 0.962105441345164 5.68435745070738e-14 0.0350805584150806 0.838402939094343 miRNATAP -0.166500592070897 0.00292442932434278 NA NA NA hsa-miR-125a-3p CYCS -0.335450161542356 0.00400908432417966 0.12599024617669 0.0662944645469151 miRanda -0.055483748093107 0.0294830395478468 NA NA NA hsa-miR-139-5p CYCS -0.248477989074291 0.0406493945332495 0.12599024617669 0.0662944645469151 miRanda -0.146688731246083 6.81627041550216e-10 NA NA NA hsa-miR-145-5p DFFA -0.0645550892386986 0.583308140519106 -0.198010794764904 3.18957759265652e-05 miRNAWalker2_validate;miRTarBase -0.0653926958299852 0.000155667071434826 NA NA NA hsa-miR-148a-3p DFFA 1.85007671007711 2.47199960189831e-52 -0.198010794764904 3.18957759265652e-05 mirMAP -0.0637011747541256 2.40723901204855e-05 NA NA NA hsa-miR-26b-5p DFFA 0.737437044119261 6.43607077095392e-18 -0.198010794764904 3.18957759265652e-05 mirMAP -0.140798155806619 7.60131540335878e-10 NA NA NA hsa-miR-320a DFFA 0.995486653328461 1.19389676663043e-20 -0.198010794764904 3.18957759265652e-05 miRanda -0.126660842700811 2.23360208767096e-12 NA NA NA hsa-miR-335-5p DFFA 0.960193718665196 5.23061119483499e-12 -0.198010794764904 3.18957759265652e-05 mirMAP -0.0715308956472775 4.83313813262831e-07 NA NA NA hsa-miR-339-5p DFFA 0.986556478524229 2.39294233177816e-12 -0.198010794764904 3.18957759265652e-05 miRanda -0.0734307252030485 1.65994418259898e-07 NA NA NA hsa-miR-342-3p DFFA 1.25856075011434 9.50396545654544e-34 -0.198010794764904 3.18957759265652e-05 mirMAP -0.121581327797446 1.87367750161826e-11 NA NA NA hsa-miR-374a-3p DFFA 0.613148065516 1.92239481728524e-11 -0.198010794764904 3.18957759265652e-05 mirMAP -0.0626477475787731 0.00435444962778197 NA NA NA hsa-miR-374b-5p DFFA 0.221226738167834 0.00747242957932175 -0.198010794764904 3.18957759265652e-05 mirMAP -0.0979578976695251 7.14741884805454e-05 NA NA NA hsa-miR-590-5p DFFA 0.778106902153171 1.13576371947662e-09 -0.198010794764904 3.18957759265652e-05 miRanda;mirMAP -0.0549589521993868 0.000448331980884681 NA NA NA hsa-miR-664a-3p DFFA 0.771665734879281 3.09460128204919e-14 -0.198010794764904 3.18957759265652e-05 mirMAP -0.092974023528172 1.80058908248033e-06 NA NA NA hsa-miR-330-3p DFFB -0.648758240701829 1.73283773523946e-07 0.515645638566068 3.03277531043259e-14 mirMAP -0.111727719212166 2.48847015619686e-06 NA NA NA hsa-miR-125a-3p ENDOD1 -0.335450161542356 0.00400908432417966 0.383217468964999 0.00262340270491255 miRanda -0.123655570799816 0.00923158816873902 NA NA NA hsa-miR-129-5p ENDOD1 -0.664119897121714 0.00207371121658161 0.383217468964999 0.00262340270491255 MirTarget;miRanda -0.0708527908896787 0.00663337174464731 NA NA NA hsa-miR-16-1-3p ENDOD1 0.6666012357419 1.32179543917662e-06 0.383217468964999 0.00262340270491255 mirMAP -0.099461453444993 0.0119847404910169 NA NA NA hsa-miR-181c-5p ENDOD1 -0.216106163143199 0.0372442927577819 0.383217468964999 0.00262340270491255 MirTarget -0.165693529923658 0.00165476384249399 NA NA NA hsa-miR-181d-5p ENDOD1 0.0618695590440579 0.550187163548148 0.383217468964999 0.00262340270491255 MirTarget -0.113383059452186 0.0323868035666572 NA NA NA hsa-miR-200b-3p ENDOD1 0.520479887309497 0.0201824904182445 0.383217468964999 0.00262340270491255 TargetScan -0.102095077332235 2.33502845787443e-05 NA NA NA hsa-miR-330-5p ENDOD1 -0.493301557454585 1.71135028785136e-05 0.383217468964999 0.00262340270491255 miRanda -0.228360026583252 1.15079272848739e-06 NA NA NA hsa-miR-335-3p ENDOD1 0.625191833097361 1.64208673352826e-06 0.383217468964999 0.00262340270491255 MirTarget -0.117216473816576 0.00468560354142988 NA NA NA hsa-miR-429 ENDOD1 0.682420529994948 0.00462213397220855 0.383217468964999 0.00262340270491255 miRanda;miRNATAP -0.0938904522486888 2.85905079382194e-05 NA NA NA hsa-miR-24-3p EXOG -0.460804468884136 9.35756069405165e-09 -0.0780212876076511 0.126690072078769 MirTarget -0.0544611452314544 0.0433360922722601 NA NA NA hsa-let-7a-5p FAS 0.810823676990504 1.01381033479571e-26 -0.765984713687569 4.65332559803096e-10 TargetScan -0.367907639319651 3.83985731887709e-08 NA NA NA hsa-miR-106a-5p FAS 1.76751200862602 7.79031604495348e-24 -0.765984713687569 4.65332559803096e-10 miRNAWalker2_validate;miRTarBase -0.224581408508156 2.12276558169129e-15 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-140-5p FAS 0.71404697529503 8.18104415848614e-20 -0.765984713687569 4.65332559803096e-10 miRanda -0.274029282581853 3.25615514248829e-05 NA NA NA hsa-miR-21-5p FAS 1.03478217459822 8.05139001473458e-27 -0.765984713687569 4.65332559803096e-10 miRNAWalker2_validate -0.134952205802786 0.0106272660301837 24710931 miR 21 targets Fas ligand mediated apoptosis in breast cancer cell line MCF 7 breast cancer hsa-miR-361-5p FAS 0.65220098099292 2.23302456529998e-21 -0.765984713687569 4.65332559803096e-10 miRanda -0.443164018079524 2.95610508594929e-09 NA NA NA hsa-miR-491-5p FAS 0.996821208926168 6.43686029153552e-11 -0.765984713687569 4.65332559803096e-10 miRanda -0.219586024892226 1.00105113386475e-10 NA NA NA hsa-miR-504-5p FAS 0.385434930771299 0.00197175199036537 -0.765984713687569 4.65332559803096e-10 miRNAWalker2_validate -0.14063220043666 0.00101138626241347 NA NA NA hsa-miR-590-5p FAS 0.778106902153171 1.13576371947662e-09 -0.765984713687569 4.65332559803096e-10 miRanda -0.264079038080719 6.9692103312146e-11 NA NA NA hsa-let-7a-5p FASLG 0.810823676990504 1.01381033479571e-26 0.0834492142857672 0.684177836138314 TargetScan;miRNATAP -0.281920114994156 0.0110732972594003 NA NA NA hsa-miR-32-5p FASLG 0.919129456898534 9.58217908368018e-12 0.0834492142857672 0.684177836138314 miRNATAP -0.172426644027698 0.00673899931646685 NA NA NA hsa-miR-92a-3p FASLG 1.46190744132999 3.47140194919364e-41 0.0834492142857672 0.684177836138314 miRNATAP -0.236906508778942 0.0014633900607721 NA NA NA hsa-miR-326 IKBKB -0.893385784609658 5.72581663211179e-08 0.131492542622156 0.0965921974497363 miRanda -0.0561772729913016 0.00586138993428555 NA NA NA hsa-miR-542-3p IKBKB -0.318649418920791 0.0301489241026751 0.131492542622156 0.0965921974497363 miRanda -0.0602039136506483 0.00866943011843738 NA NA NA hsa-miR-107 IKBKG -0.0765084476717215 0.299642610307986 0.0514264410229481 0.341995016539972 miRanda -0.0882707967748443 0.00514867109461552 NA NA NA hsa-miR-143-3p IKBKG -1.04476349103257 1.5371074233558e-21 0.0514264410229481 0.341995016539972 mirMAP -0.082960261537642 3.75949909447339e-05 NA NA NA hsa-miR-24-3p IKBKG -0.460804468884136 9.35756069405165e-09 0.0514264410229481 0.341995016539972 mirMAP -0.110760628492181 9.67025632552443e-05 NA NA NA hsa-miR-330-3p IKBKG -0.648758240701829 1.73283773523946e-07 0.0514264410229481 0.341995016539972 mirMAP -0.0669198261266705 0.000292415044602344 NA NA NA hsa-miR-30d-3p IL1B 0.917692758870644 7.72239658481305e-16 -0.69398032610289 0.00546576617774173 MirTarget -0.192846816813458 0.035361073988438 NA NA NA hsa-miR-590-5p IL1B 0.778106902153171 1.13576371947662e-09 -0.69398032610289 0.00546576617774173 MirTarget;miRanda;miRNATAP -0.279105545536865 0.000699135229829398 NA NA NA hsa-miR-7-1-3p IL1B 1.45703750327525 1.75378847810395e-30 -0.69398032610289 0.00546576617774173 MirTarget -0.297647145709346 0.000175949803642678 NA NA NA hsa-miR-140-5p IL1R1 0.71404697529503 8.18104415848614e-20 -0.280120282092358 0.0158885509748962 miRanda -0.165602223125138 0.00723994099495919 NA NA NA hsa-miR-186-5p IL1R1 0.567811924899218 1.37607142180899e-13 -0.280120282092358 0.0158885509748962 mirMAP -0.193222224976058 0.00244484239963438 NA NA NA hsa-miR-192-5p IL1R1 0.245629178320705 0.0371144833362312 -0.280120282092358 0.0158885509748962 miRNAWalker2_validate -0.0974234108407763 0.0210618708022448 NA NA NA hsa-miR-197-3p IL1R1 0.949753058740866 6.25249252362886e-21 -0.280120282092358 0.0158885509748962 miRNAWalker2_validate -0.0991131390448014 0.0367840889170096 NA NA NA hsa-miR-335-3p IL1R1 0.625191833097361 1.64208673352826e-06 -0.280120282092358 0.0158885509748962 mirMAP -0.116190501184063 0.0020645338863397 NA NA NA hsa-miR-495-3p IL1R1 0.627906813412205 1.45002911833628e-07 -0.280120282092358 0.0158885509748962 mirMAP -0.0945548304545277 0.0219630938128693 NA NA NA hsa-miR-106a-5p IL1RAP 1.76751200862602 7.79031604495348e-24 -0.42415395635021 0.000145392776670789 MirTarget -0.194990762246016 1.91345215910194e-14 NA NA NA hsa-miR-106b-5p IL1RAP 1.03194006819592 5.97693261279744e-24 -0.42415395635021 0.000145392776670789 MirTarget -0.240084055965926 7.00082497582705e-08 NA NA NA hsa-miR-130a-3p IL1RAP -0.00961131533334481 0.934528436621983 -0.42415395635021 0.000145392776670789 MirTarget -0.19540371765139 1.66997321876194e-06 NA NA NA hsa-miR-130b-3p IL1RAP 1.0141083264891 9.96856467852316e-16 -0.42415395635021 0.000145392776670789 MirTarget -0.149156158467146 4.9790633767611e-05 NA NA NA hsa-miR-139-5p IL1RAP -0.248477989074291 0.0406493945332495 -0.42415395635021 0.000145392776670789 miRanda -0.118397242161259 0.00271075784524366 NA NA NA hsa-miR-140-5p IL1RAP 0.71404697529503 8.18104415848614e-20 -0.42415395635021 0.000145392776670789 miRanda -0.218399750256465 0.000232034927486745 NA NA NA hsa-miR-16-1-3p IL1RAP 0.6666012357419 1.32179543917662e-06 -0.42415395635021 0.000145392776670789 mirMAP -0.106288258003454 0.00220960303002792 NA NA NA hsa-miR-17-5p IL1RAP 1.75236465070226 3.95158641628068e-36 -0.42415395635021 0.000145392776670789 MirTarget;TargetScan -0.254997802977606 2.85011879427333e-16 NA NA NA hsa-miR-186-5p IL1RAP 0.567811924899218 1.37607142180899e-13 -0.42415395635021 0.000145392776670789 mirMAP -0.427918989056758 1.38145871424901e-12 NA NA NA hsa-miR-190a-5p IL1RAP -0.163976032931054 0.241051169305018 -0.42415395635021 0.000145392776670789 MirTarget -0.0910435779461383 0.00812056994430528 NA NA NA hsa-miR-199a-5p IL1RAP 0.568593261495707 4.98517644263161e-07 -0.42415395635021 0.000145392776670789 miRanda -0.182400904114391 1.28263348353525e-05 NA NA NA hsa-miR-199b-5p IL1RAP 1.17761875205879 1.049059589835e-17 -0.42415395635021 0.000145392776670789 miRanda -0.142217320676669 2.32743105418995e-05 NA NA NA hsa-miR-19a-3p IL1RAP 1.31708679186777 4.80964007387826e-14 -0.42415395635021 0.000145392776670789 MirTarget -0.211409431057736 4.43369544539536e-16 NA NA NA hsa-miR-19b-3p IL1RAP 1.59390221063917 1.21812878827888e-26 -0.42415395635021 0.000145392776670789 MirTarget -0.287837727829286 9.90061674252095e-23 NA NA NA hsa-miR-204-5p IL1RAP -1.00950273930717 9.21834560704471e-10 -0.42415395635021 0.000145392776670789 miRNAWalker2_validate -0.087891550116051 0.00207809903808559 NA NA NA hsa-miR-20a-5p IL1RAP 1.8613782696103 3.92351368893256e-34 -0.42415395635021 0.000145392776670789 MirTarget -0.215179790178152 6.77271894815634e-14 NA NA NA hsa-miR-20b-5p IL1RAP 1.58314196476132 5.61327965534646e-17 -0.42415395635021 0.000145392776670789 MirTarget -0.162321777319058 1.69391489759331e-11 NA NA NA hsa-miR-299-5p IL1RAP -0.339487251625369 0.0148257327495998 -0.42415395635021 0.000145392776670789 miRNATAP -0.0862286851706904 0.0135773969004585 NA NA NA hsa-miR-29b-3p IL1RAP 0.30584521532637 0.00477759838414942 -0.42415395635021 0.000145392776670789 MirTarget;miRNATAP -0.321485289128175 1.10424440544043e-13 NA NA NA hsa-miR-301a-3p IL1RAP 0.501721475120081 0.000262747397142618 -0.42415395635021 0.000145392776670789 MirTarget -0.206495272377899 1.69466569157435e-09 NA NA NA hsa-miR-3065-5p IL1RAP 1.04645334963496 3.19942342920484e-08 -0.42415395635021 0.000145392776670789 mirMAP -0.113074735786244 6.99132211068675e-06 NA NA NA hsa-miR-320a IL1RAP 0.995486653328461 1.19389676663043e-20 -0.42415395635021 0.000145392776670789 MirTarget;PITA;miRanda -0.215798079305238 5.06305798338135e-07 NA NA NA hsa-miR-335-3p IL1RAP 0.625191833097361 1.64208673352826e-06 -0.42415395635021 0.000145392776670789 mirMAP -0.0855250439275137 0.0189831840841129 NA NA NA hsa-miR-339-5p IL1RAP 0.986556478524229 2.39294233177816e-12 -0.42415395635021 0.000145392776670789 miRanda -0.267196714526628 1.74356190006405e-16 NA NA NA hsa-miR-3607-3p IL1RAP 1.16606393006353 2.28951370382033e-07 -0.42415395635021 0.000145392776670789 mirMAP -0.103571057596073 6.47514325102292e-07 NA NA NA hsa-miR-361-5p IL1RAP 0.65220098099292 2.23302456529998e-21 -0.42415395635021 0.000145392776670789 miRanda -0.43413525982928 8.35039168243986e-11 NA NA NA hsa-miR-362-3p IL1RAP 0.332355427232084 0.0356765384646952 -0.42415395635021 0.000145392776670789 miRanda -0.146888529560585 1.35634959696223e-06 NA NA NA hsa-miR-375 IL1RAP 3.0764157413036 1.01411669962466e-67 -0.42415395635021 0.000145392776670789 miRNAWalker2_validate;miRanda -0.0623277278642476 0.00866088118341736 NA NA NA hsa-miR-454-3p IL1RAP 1.05348676011504 1.08188735671639e-16 -0.42415395635021 0.000145392776670789 MirTarget -0.254456902336147 1.53421578985279e-12 NA NA NA hsa-miR-455-5p IL1RAP -0.485855374388109 0.000213721591485816 -0.42415395635021 0.000145392776670789 miRanda -0.0938839840212043 0.00991159788739892 NA NA NA hsa-miR-542-3p IL1RAP -0.318649418920791 0.0301489241026751 -0.42415395635021 0.000145392776670789 MirTarget;miRanda -0.0944463151007279 0.00371210019551006 NA NA NA hsa-miR-576-5p IL1RAP 0.962105441345164 5.68435745070738e-14 -0.42415395635021 0.000145392776670789 mirMAP -0.194972425077383 7.21057111657753e-08 NA NA NA hsa-miR-582-5p IL1RAP 0.306116891157887 0.0402663500947974 -0.42415395635021 0.000145392776670789 MirTarget -0.183628593754576 6.83954390858321e-09 NA NA NA hsa-miR-590-3p IL1RAP 0.58484153433625 1.6489232844135e-06 -0.42415395635021 0.000145392776670789 MirTarget;miRanda;mirMAP -0.16092810711054 3.46048145806866e-05 NA NA NA hsa-miR-590-5p IL1RAP 0.778106902153171 1.13576371947662e-09 -0.42415395635021 0.000145392776670789 miRanda -0.214091593640468 4.46628702905247e-09 NA NA NA hsa-miR-664a-3p IL1RAP 0.771665734879281 3.09460128204919e-14 -0.42415395635021 0.000145392776670789 mirMAP -0.322391860709438 1.0666763114963e-12 NA NA NA hsa-miR-7-1-3p IL1RAP 1.45703750327525 1.75378847810395e-30 -0.42415395635021 0.000145392776670789 MirTarget -0.165974391418435 2.77837558299431e-06 NA NA NA hsa-miR-93-5p IL1RAP 2.02673564951392 4.11722430511325e-49 -0.42415395635021 0.000145392776670789 MirTarget -0.215421014548185 4.33077697947865e-12 NA NA NA hsa-miR-222-3p IRAK1 -0.953446345586859 1.89596390370367e-13 0.606250371497209 4.70246792998001e-17 miRNAWalker2_validate -0.22521230365215 1.25255053432272e-22 NA NA NA hsa-miR-330-5p IRAK1 -0.493301557454585 1.71135028785136e-05 0.606250371497209 4.70246792998001e-17 miRNAWalker2_validate -0.104549814356059 0.00013896796383578 NA NA NA hsa-miR-3065-5p IRAK2 1.04645334963496 3.19942342920484e-08 -0.401501894397779 0.000621465437456517 mirMAP -0.127099168265292 1.44115569731479e-06 NA NA NA hsa-miR-320a IRAK2 0.995486653328461 1.19389676663043e-20 -0.401501894397779 0.000621465437456517 miRanda;miRNATAP -0.181864798081714 5.89339881738042e-05 NA NA NA hsa-miR-335-5p IRAK2 0.960193718665196 5.23061119483499e-12 -0.401501894397779 0.000621465437456517 miRNAWalker2_validate -0.0757394347793134 0.0326866092844667 NA NA NA hsa-miR-339-5p IRAK2 0.986556478524229 2.39294233177816e-12 -0.401501894397779 0.000621465437456517 miRanda -0.189654122936379 4.34049342736124e-08 NA NA NA hsa-miR-140-5p IRAK3 0.71404697529503 8.18104415848614e-20 -1.21609927281653 1.61819406073314e-18 mirMAP -0.256899630647233 0.000701434357171348 NA NA NA hsa-miR-141-3p IRAK3 1.79566520772935 2.4341426730525e-29 -1.21609927281653 1.61819406073314e-18 mirMAP -0.499568832822572 1.83508866562787e-52 NA NA NA hsa-miR-148b-5p IRAK3 1.04534361724991 2.31801722055734e-12 -1.21609927281653 1.61819406073314e-18 mirMAP -0.352863256200957 4.72880549092705e-18 NA NA NA hsa-miR-16-1-3p IRAK3 0.6666012357419 1.32179543917662e-06 -1.21609927281653 1.61819406073314e-18 mirMAP -0.155799699808921 0.00043280816797028 NA NA NA hsa-miR-16-2-3p IRAK3 0.615426607127207 4.1394319273097e-05 -1.21609927281653 1.61819406073314e-18 mirMAP -0.218641691035623 9.67271195930017e-08 NA NA NA hsa-miR-16-5p IRAK3 0.54730888568038 1.14657883125954e-10 -1.21609927281653 1.61819406073314e-18 miRNAWalker2_validate -0.45882237232558 6.17301157914279e-11 NA NA NA hsa-miR-186-5p IRAK3 0.567811924899218 1.37607142180899e-13 -1.21609927281653 1.61819406073314e-18 mirMAP -0.637113944595738 7.62516480441317e-17 NA NA NA hsa-miR-188-5p IRAK3 0.380696438407781 0.0146292832066358 -1.21609927281653 1.61819406073314e-18 mirMAP -0.134206436673362 0.000749661986052904 NA NA NA hsa-miR-199b-5p IRAK3 1.17761875205879 1.049059589835e-17 -1.21609927281653 1.61819406073314e-18 miRanda -0.0862988268347444 0.0456703441130353 NA NA NA hsa-miR-200a-3p IRAK3 0.478106750145322 0.0392078876144627 -1.21609927281653 1.61819406073314e-18 mirMAP -0.0708383599351405 0.00705949485191083 NA NA NA hsa-miR-20a-3p IRAK3 1.93545996942606 5.86749215003338e-31 -1.21609927281653 1.61819406073314e-18 mirMAP -0.380329140192535 1.18811178864971e-31 NA NA NA hsa-miR-21-5p IRAK3 1.03478217459822 8.05139001473458e-27 -1.21609927281653 1.61819406073314e-18 mirMAP -0.369739641028922 5.80239142443293e-10 NA NA NA hsa-miR-25-3p IRAK3 1.48824362562014 5.9514552944441e-55 -1.21609927281653 1.61819406073314e-18 mirMAP -0.716597817129626 1.23027846964455e-40 NA NA NA hsa-miR-29b-2-5p IRAK3 0.789021480062024 2.59438538341201e-14 -1.21609927281653 1.61819406073314e-18 mirMAP -0.362850313719811 1.83277918774917e-10 NA NA NA hsa-miR-32-5p IRAK3 0.919129456898534 9.58217908368018e-12 -1.21609927281653 1.61819406073314e-18 mirMAP -0.431721584483174 3.783537155951e-24 NA NA NA hsa-miR-320a IRAK3 0.995486653328461 1.19389676663043e-20 -1.21609927281653 1.61819406073314e-18 miRanda -0.247671595254223 6.58285012621946e-06 NA NA NA hsa-miR-324-5p IRAK3 0.539970285576227 1.69955273262765e-05 -1.21609927281653 1.61819406073314e-18 miRanda -0.273620687240771 1.09289571396417e-08 NA NA NA hsa-miR-335-3p IRAK3 0.625191833097361 1.64208673352826e-06 -1.21609927281653 1.61819406073314e-18 mirMAP -0.360749435470278 1.74477295727978e-15 NA NA NA hsa-miR-33a-5p IRAK3 -0.0191758999894391 0.924819190352805 -1.21609927281653 1.61819406073314e-18 mirMAP -0.165457157733696 2.67629863511565e-08 NA NA NA hsa-miR-340-5p IRAK3 0.418767158937086 8.44911569437093e-06 -1.21609927281653 1.61819406073314e-18 mirMAP -0.188462845886495 0.00366295437048944 NA NA NA hsa-miR-361-5p IRAK3 0.65220098099292 2.23302456529998e-21 -1.21609927281653 1.61819406073314e-18 miRanda;mirMAP -0.468638439942032 4.73688721952696e-08 NA NA NA hsa-miR-363-3p IRAK3 1.00269053441578 1.08997020195393e-10 -1.21609927281653 1.61819406073314e-18 mirMAP -0.319644225949963 1.62534733246989e-17 NA NA NA hsa-miR-374a-3p IRAK3 0.613148065516 1.92239481728524e-11 -1.21609927281653 1.61819406073314e-18 mirMAP -0.195535811569471 0.00305804977940936 NA NA NA hsa-miR-429 IRAK3 0.682420529994948 0.00462213397220855 -1.21609927281653 1.61819406073314e-18 miRanda -0.0864214035075628 0.000614297601705686 NA NA NA hsa-miR-582-5p IRAK3 0.306116891157887 0.0402663500947974 -1.21609927281653 1.61819406073314e-18 mirMAP -0.130800508847783 0.00137789830379218 NA NA NA hsa-miR-590-3p IRAK3 0.58484153433625 1.6489232844135e-06 -1.21609927281653 1.61819406073314e-18 miRanda;mirMAP -0.315101542722063 1.34793935664361e-10 NA NA NA hsa-miR-590-5p IRAK3 0.778106902153171 1.13576371947662e-09 -1.21609927281653 1.61819406073314e-18 mirMAP -0.376253901280294 2.47212951699171e-16 NA NA NA hsa-miR-660-5p IRAK3 1.14400353328339 2.69534153134519e-19 -1.21609927281653 1.61819406073314e-18 mirMAP -0.244948052958752 9.81218176173951e-08 NA NA NA hsa-miR-7-1-3p IRAK3 1.45703750327525 1.75378847810395e-30 -1.21609927281653 1.61819406073314e-18 mirMAP -0.55148764806354 8.10716985062823e-39 NA NA NA hsa-miR-708-3p IRAK3 1.69343810530707 2.2954130070802e-38 -1.21609927281653 1.61819406073314e-18 mirMAP -0.239936730585321 2.44862481656255e-08 NA NA NA hsa-miR-92a-3p IRAK3 1.46190744132999 3.47140194919364e-41 -1.21609927281653 1.61819406073314e-18 mirMAP -0.656041792000522 2.3194251827253e-42 NA NA NA hsa-miR-195-3p IRAK4 0.598450619600341 1.01415597921415e-08 -0.199775820728182 1.03089128982745e-05 mirMAP -0.0635744918164907 0.000524314404457013 NA NA NA hsa-miR-320a IRAK4 0.995486653328461 1.19389676663043e-20 -0.199775820728182 1.03089128982745e-05 miRanda -0.0633574765080537 0.000284863535329249 NA NA NA hsa-miR-106b-5p MAP3K14 1.03194006819592 5.97693261279744e-24 -0.540754425598404 9.56030152673458e-08 MirTarget -0.104859752265228 0.0107303789661728 NA NA NA hsa-miR-17-3p MAP3K14 1.00900556864081 4.33187133364725e-23 -0.540754425598404 9.56030152673458e-08 MirTarget -0.125667218048129 0.00230848606457127 NA NA NA hsa-miR-17-5p MAP3K14 1.75236465070226 3.95158641628068e-36 -0.540754425598404 9.56030152673458e-08 MirTarget -0.0756126023858498 0.00977952514743775 NA NA NA hsa-miR-20a-5p MAP3K14 1.8613782696103 3.92351368893256e-34 -0.540754425598404 9.56030152673458e-08 MirTarget -0.0599599053956802 0.0255545514616056 NA NA NA hsa-miR-423-5p MAP3K14 1.76013839591803 2.19994178835104e-44 -0.540754425598404 9.56030152673458e-08 MirTarget -0.0987178283455226 0.00197332276709367 NA NA NA hsa-miR-93-5p MAP3K14 2.02673564951392 4.11722430511325e-49 -0.540754425598404 9.56030152673458e-08 MirTarget -0.127191034357054 9.90339193542841e-06 NA NA NA hsa-miR-29b-2-5p MYD88 0.789021480062024 2.59438538341201e-14 0.0679239326498502 0.242738139477846 MirTarget -0.116908211326429 4.51920896354222e-07 NA NA NA hsa-miR-365a-3p MYD88 0.549429463477979 3.33080608258095e-07 0.0679239326498502 0.242738139477846 MirTarget -0.109829577235124 1.21156745837594e-06 NA NA NA hsa-miR-455-5p MYD88 -0.485855374388109 0.000213721591485816 0.0679239326498502 0.242738139477846 miRanda -0.0672015419162154 0.000334063136911572 NA NA NA hsa-miR-660-5p MYD88 1.14400353328339 2.69534153134519e-19 0.0679239326498502 0.242738139477846 MirTarget -0.0809633361797996 1.43091462535005e-05 NA NA NA hsa-let-7a-5p NFKB1 0.810823676990504 1.01381033479571e-26 -0.197148824071358 0.00505075288525607 miRNAWalker2_validate -0.134271046750632 0.000405559450055721 NA NA NA hsa-miR-15a-5p NFKB1 0.922713188178758 6.51407511505232e-18 -0.197148824071358 0.00505075288525607 miRNAWalker2_validate -0.11267631779216 3.28081742823241e-05 NA NA NA hsa-miR-16-5p NFKB1 0.54730888568038 1.14657883125954e-10 -0.197148824071358 0.00505075288525607 miRNAWalker2_validate -0.0757344434610763 0.0307328008437054 NA NA NA hsa-miR-199a-5p NFKB1 0.568593261495707 4.98517644263161e-07 -0.197148824071358 0.00505075288525607 miRanda -0.0885863424019191 0.000754580346266739 18408758 Regulation of IKKbeta by miR 199a affects NF kappaB activity in ovarian cancer cells ovarian cancer hsa-miR-199b-5p NFKB1 1.17761875205879 1.049059589835e-17 -0.197148824071358 0.00505075288525607 miRanda -0.0635757963651618 0.00265238842083516 NA NA NA hsa-miR-210-3p NFKB1 1.20874305422069 2.66185692386821e-06 -0.197148824071358 0.00505075288525607 miRNAWalker2_validate -0.0595296201277351 1.89273751798574e-07 NA NA NA hsa-miR-26b-5p NFKB1 0.737437044119261 6.43607077095392e-18 -0.197148824071358 0.00505075288525607 miRNAWalker2_validate -0.182321218497912 7.56546087787525e-08 NA NA NA hsa-miR-590-3p NFKB1 0.58484153433625 1.6489232844135e-06 -0.197148824071358 0.00505075288525607 miRanda;mirMAP -0.112271855008841 3.87559745127326e-06 24200043 We identified important regulators MYC NFKB1 miR-590 and miR-570 and significant miRNA-TF synergistic regulatory motifs by random simulations lung squamous cell cancer hsa-miR-671-5p NFKB1 1.21418487247953 1.04429628542981e-14 -0.197148824071358 0.00505075288525607 MirTarget -0.0923223160641438 2.04909146352728e-06 NA NA NA hsa-miR-92a-3p NFKB1 1.46190744132999 3.47140194919364e-41 -0.197148824071358 0.00505075288525607 miRNAWalker2_validate -0.152454340164633 1.5357157655945e-09 NA NA NA hsa-let-7b-5p NFKBIA 0.221439854958533 0.00904814983284612 -0.287137057093179 2.83244840835316e-05 miRNAWalker2_validate -0.0999715964970568 0.00413874709213231 NA NA NA hsa-let-7a-5p NGF 0.810823676990504 1.01381033479571e-26 -0.657456760504721 3.97760065391802e-05 MirTarget;TargetScan -0.453226644235112 1.53966908455352e-07 NA NA NA hsa-let-7b-5p NGF 0.221439854958533 0.00904814983284612 -0.657456760504721 3.97760065391802e-05 MirTarget -0.260138306864185 0.00140281759325253 NA NA NA hsa-miR-423-5p NGF 1.76013839591803 2.19994178835104e-44 -0.657456760504721 3.97760065391802e-05 MirTarget;miRNATAP -0.109447299099894 0.0294082601183476 NA NA NA hsa-miR-429 NGF 0.682420529994948 0.00462213397220855 -0.657456760504721 3.97760065391802e-05 miRanda -0.0940461205405605 0.000921831468442752 NA NA NA hsa-let-7a-5p PIK3CA 0.810823676990504 1.01381033479571e-26 -0.410712623511572 8.88228871249929e-05 TargetScan -0.180396472264907 0.00153231776468412 NA NA NA hsa-miR-146b-5p PIK3CA 1.70281490248323 9.08060943822639e-35 -0.410712623511572 8.88228871249929e-05 mirMAP -0.0730906881390646 0.0163249804744776 NA NA NA hsa-miR-16-2-3p PIK3CA 0.615426607127207 4.1394319273097e-05 -0.410712623511572 8.88228871249929e-05 mirMAP -0.146843738231288 1.1781482582756e-06 NA NA NA hsa-miR-17-5p PIK3CA 1.75236465070226 3.95158641628068e-36 -0.410712623511572 8.88228871249929e-05 miRNAWalker2_validate -0.244853060728267 5.36215014850866e-17 NA NA NA hsa-miR-186-5p PIK3CA 0.567811924899218 1.37607142180899e-13 -0.410712623511572 8.88228871249929e-05 mirMAP -0.309242510965327 6.56593673123575e-08 NA NA NA hsa-miR-29b-1-5p PIK3CA 1.06520673410615 4.43912716822893e-11 -0.410712623511572 8.88228871249929e-05 mirMAP -0.112371081414666 6.28224597907277e-05 NA NA NA hsa-miR-320a PIK3CA 0.995486653328461 1.19389676663043e-20 -0.410712623511572 8.88228871249929e-05 miRanda -0.299361484074285 5.05563063793088e-14 NA NA NA hsa-miR-335-3p PIK3CA 0.625191833097361 1.64208673352826e-06 -0.410712623511572 8.88228871249929e-05 mirMAP -0.106310311740245 0.00185813825793794 NA NA NA hsa-miR-335-5p PIK3CA 0.960193718665196 5.23061119483499e-12 -0.410712623511572 8.88228871249929e-05 miRNAWalker2_validate -0.123195397071701 9.48778045734955e-05 NA NA NA hsa-miR-339-5p PIK3CA 0.986556478524229 2.39294233177816e-12 -0.410712623511572 8.88228871249929e-05 miRanda -0.228830148314723 7.72833888673999e-14 NA NA NA hsa-miR-3607-3p PIK3CA 1.16606393006353 2.28951370382033e-07 -0.410712623511572 8.88228871249929e-05 mirMAP -0.0802739991805218 4.24945343978395e-05 NA NA NA hsa-miR-361-5p PIK3CA 0.65220098099292 2.23302456529998e-21 -0.410712623511572 8.88228871249929e-05 mirMAP -0.331477910612998 1.54903325363168e-07 NA NA NA hsa-miR-374b-5p PIK3CA 0.221226738167834 0.00747242957932175 -0.410712623511572 8.88228871249929e-05 mirMAP -0.260629894503142 1.61828207777705e-06 NA NA NA hsa-miR-485-3p PIK3CA 0.378196908999646 0.0116649746326721 -0.410712623511572 8.88228871249929e-05 mirMAP -0.0737697910134611 0.0152006564618008 NA NA NA hsa-miR-491-5p PIK3CA 0.996821208926168 6.43686029153552e-11 -0.410712623511572 8.88228871249929e-05 miRanda -0.0745763528490907 0.0103579361146451 NA NA NA hsa-miR-495-3p PIK3CA 0.627906813412205 1.45002911833628e-07 -0.410712623511572 8.88228871249929e-05 mirMAP -0.113629698534641 0.00232757773504127 NA NA NA hsa-miR-576-5p PIK3CA 0.962105441345164 5.68435745070738e-14 -0.410712623511572 8.88228871249929e-05 PITA -0.157552861680745 3.84348331241354e-06 NA NA NA hsa-miR-582-3p PIK3CA 0.693858322916386 6.21181920448093e-07 -0.410712623511572 8.88228871249929e-05 miRNATAP -0.190486688968754 1.6124377596937e-09 NA NA NA hsa-miR-590-3p PIK3CA 0.58484153433625 1.6489232844135e-06 -0.410712623511572 8.88228871249929e-05 miRanda;mirMAP -0.148802730529184 4.55351023292317e-05 NA NA NA hsa-miR-590-5p PIK3CA 0.778106902153171 1.13576371947662e-09 -0.410712623511572 8.88228871249929e-05 miRanda -0.151960580071619 1.05920292342021e-05 NA NA NA hsa-miR-7-1-3p PIK3CA 1.45703750327525 1.75378847810395e-30 -0.410712623511572 8.88228871249929e-05 mirMAP -0.19255440498201 5.77550459225916e-09 NA NA NA hsa-miR-96-5p PIK3CA 2.57339472553563 5.77311209747788e-53 -0.410712623511572 8.88228871249929e-05 TargetScan -0.187479209558979 1.67217105597386e-15 NA NA NA hsa-miR-130a-3p PIK3CB -0.00961131533334481 0.934528436621983 0.145646697635999 0.0575869280823223 miRNATAP -0.158332637480705 1.12947777698355e-08 NA NA NA hsa-miR-195-3p PIK3CB 0.598450619600341 1.01415597921415e-08 0.145646697635999 0.0575869280823223 mirMAP -0.0929824052015833 0.00270629265987699 NA NA NA hsa-miR-200b-3p PIK3CB 0.520479887309497 0.0201824904182445 0.145646697635999 0.0575869280823223 TargetScan -0.0523830075988808 0.000305416969733267 NA NA NA hsa-miR-204-5p PIK3CB -1.00950273930717 9.21834560704471e-10 0.145646697635999 0.0575869280823223 miRNATAP -0.11043540881395 1.02014975635691e-08 NA NA NA hsa-miR-214-3p PIK3CB 0.252925892562357 0.0557511112852669 0.145646697635999 0.0575869280823223 miRNATAP -0.121661881719815 7.82804169879894e-07 NA NA NA hsa-miR-301a-3p PIK3CB 0.501721475120081 0.000262747397142618 0.145646697635999 0.0575869280823223 miRNATAP -0.0504020148951343 0.0337603709173796 NA NA NA hsa-miR-454-3p PIK3CB 1.05348676011504 1.08188735671639e-16 0.145646697635999 0.0575869280823223 miRNATAP -0.0680530474812557 0.00658998453685856 NA NA NA hsa-miR-455-5p PIK3CB -0.485855374388109 0.000213721591485816 0.145646697635999 0.0575869280823223 miRNATAP -0.132607669874494 7.02112152032612e-08 NA NA NA hsa-miR-9-5p PIK3CB 1.13944963456975 4.52386797543086e-07 0.145646697635999 0.0575869280823223 miRNATAP -0.0621873248601015 1.23033550307487e-05 NA NA NA hsa-miR-92b-3p PIK3CB 0.0515531008682348 0.658460162557137 0.145646697635999 0.0575869280823223 miRNATAP -0.0800966849986224 0.00440755878093371 NA NA NA hsa-miR-10b-5p PIK3CD 0.833433858224828 5.14196469408274e-10 -0.556402578789972 4.3470761935334e-05 miRNAWalker2_validate -0.197238843164291 3.7634449307755e-06 NA NA NA hsa-miR-135a-5p PIK3CD 1.05960103698212 1.08082165806252e-09 -0.556402578789972 4.3470761935334e-05 miRNATAP -0.13608201580589 3.61034803286541e-05 NA NA NA hsa-miR-1468-5p PIK3CD 0.469053143305544 5.66395086652441e-05 -0.556402578789972 4.3470761935334e-05 MirTarget -0.10884403292981 0.0296924360599127 NA NA NA hsa-miR-30a-5p PIK3CD 0.50856224391991 3.02321261664547e-06 -0.556402578789972 4.3470761935334e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.197228995632359 0.000211534101383035 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30b-3p PIK3CD 1.1693697068827 7.84594435698899e-16 -0.556402578789972 4.3470761935334e-05 MirTarget -0.332843668168293 1.9438451416741e-18 NA NA NA hsa-miR-30b-5p PIK3CD 1.16764575603669 1.75395013539888e-20 -0.556402578789972 4.3470761935334e-05 MirTarget -0.276103015899701 4.0254382866882e-10 NA NA NA hsa-miR-30c-5p PIK3CD 0.746747513281495 1.32431877874944e-12 -0.556402578789972 4.3470761935334e-05 MirTarget;miRNATAP -0.146774746999395 0.00712507802410712 NA NA NA hsa-miR-30d-5p PIK3CD 0.804765144490428 1.42480384315657e-16 -0.556402578789972 4.3470761935334e-05 MirTarget;miRNATAP -0.449174824979007 3.7506144464793e-15 NA NA NA hsa-miR-324-5p PIK3CD 0.539970285576227 1.69955273262765e-05 -0.556402578789972 4.3470761935334e-05 miRanda -0.108556319791728 0.0191752434904884 NA NA NA hsa-miR-484 PIK3CD 0.968911692345786 2.45789986401578e-17 -0.556402578789972 4.3470761935334e-05 MirTarget;miRNATAP -0.248592199297219 4.4850312511167e-07 NA NA NA hsa-miR-126-3p PIK3CG 1.24504762806365 2.98982653364026e-22 -0.712358729612267 0.00109475109733129 miRTarBase -0.306226588930372 1.09190520276721e-05 NA NA NA hsa-miR-148b-3p PIK3CG 0.551634584599404 1.25985630163378e-10 -0.712358729612267 0.00109475109733129 miRNAWalker2_validate -0.215884405649396 0.0458428484384254 NA NA NA hsa-miR-26b-5p PIK3CG 0.737437044119261 6.43607077095392e-18 -0.712358729612267 0.00109475109733129 miRNAWalker2_validate -0.632143900196741 1.91643518661299e-09 NA NA NA hsa-miR-29b-3p PIK3CG 0.30584521532637 0.00477759838414942 -0.712358729612267 0.00109475109733129 miRTarBase -0.434757916111525 3.83992314156218e-07 NA NA NA hsa-miR-335-3p PIK3CG 0.625191833097361 1.64208673352826e-06 -0.712358729612267 0.00109475109733129 mirMAP -0.273487175937572 0.000113937303385509 NA NA NA hsa-miR-3607-3p PIK3CG 1.16606393006353 2.28951370382033e-07 -0.712358729612267 0.00109475109733129 mirMAP -0.150782379124996 0.000222500524379066 NA NA NA hsa-miR-590-3p PIK3CG 0.58484153433625 1.6489232844135e-06 -0.712358729612267 0.00109475109733129 miRanda -0.196408975567399 0.00999207332802875 NA NA NA hsa-let-7a-5p PIK3R1 0.810823676990504 1.01381033479571e-26 -1.04215691031254 2.00768909529534e-23 miRNAWalker2_validate -0.440982048695881 2.09706667827494e-14 NA NA NA hsa-miR-101-5p PIK3R1 0.271841925254852 0.0353202240253126 -1.04215691031254 2.00768909529534e-23 MirTarget -0.143540065625093 6.48823173334239e-05 NA NA NA hsa-miR-103a-3p PIK3R1 1.20954748107198 5.62173682108416e-44 -1.04215691031254 2.00768909529534e-23 MirTarget;miRNATAP -0.437780634520896 5.60415795997746e-20 NA NA NA hsa-miR-106a-5p PIK3R1 1.76751200862602 7.79031604495348e-24 -1.04215691031254 2.00768909529534e-23 MirTarget;miRNATAP -0.232783557456921 1.46367339615403e-21 NA NA NA hsa-miR-106b-5p PIK3R1 1.03194006819592 5.97693261279744e-24 -1.04215691031254 2.00768909529534e-23 MirTarget;miRNATAP -0.401073562177799 1.67663086536778e-21 NA NA NA hsa-miR-1301-3p PIK3R1 1.04723166514282 1.08006888220125e-14 -1.04215691031254 2.00768909529534e-23 MirTarget -0.230368211707269 2.50183629301205e-12 NA NA NA hsa-miR-153-3p PIK3R1 2.47515671687691 7.20564234459074e-37 -1.04215691031254 2.00768909529534e-23 MirTarget -0.239079176124865 4.82708222300225e-28 NA NA NA hsa-miR-15a-5p PIK3R1 0.922713188178758 6.51407511505232e-18 -1.04215691031254 2.00768909529534e-23 MirTarget -0.376911748479251 2.59098509904423e-20 NA NA NA hsa-miR-15b-5p PIK3R1 0.902378373341056 1.5233897847618e-20 -1.04215691031254 2.00768909529534e-23 MirTarget -0.418812471552315 8.01019816528379e-21 NA NA NA hsa-miR-16-2-3p PIK3R1 0.615426607127207 4.1394319273097e-05 -1.04215691031254 2.00768909529534e-23 MirTarget -0.176621697119751 1.47289832168932e-08 NA NA NA hsa-miR-16-5p PIK3R1 0.54730888568038 1.14657883125954e-10 -1.04215691031254 2.00768909529534e-23 MirTarget -0.328848680858433 8.31531927655758e-10 NA NA NA hsa-miR-17-5p PIK3R1 1.75236465070226 3.95158641628068e-36 -1.04215691031254 2.00768909529534e-23 MirTarget;TargetScan;miRNATAP -0.371075592289545 2.2474723500155e-37 NA NA NA hsa-miR-182-5p PIK3R1 2.57717136150548 4.94377928075077e-59 -1.04215691031254 2.00768909529534e-23 miRNATAP -0.311420088107703 1.89733157063278e-37 NA NA NA hsa-miR-186-5p PIK3R1 0.567811924899218 1.37607142180899e-13 -1.04215691031254 2.00768909529534e-23 mirMAP -0.456476609143931 5.650120535924e-15 NA NA NA hsa-miR-188-5p PIK3R1 0.380696438407781 0.0146292832066358 -1.04215691031254 2.00768909529534e-23 MirTarget -0.0893499666181517 0.00325707142671761 NA NA NA hsa-miR-195-3p PIK3R1 0.598450619600341 1.01415597921415e-08 -1.04215691031254 2.00768909529534e-23 MirTarget -0.142866033798005 0.00120534305803636 NA NA NA hsa-miR-199a-5p PIK3R1 0.568593261495707 4.98517644263161e-07 -1.04215691031254 2.00768909529534e-23 miRanda -0.184829127883309 5.36085611639515e-06 NA NA NA hsa-miR-199b-5p PIK3R1 1.17761875205879 1.049059589835e-17 -1.04215691031254 2.00768909529534e-23 miRanda -0.202446500239441 4.00221301665785e-10 NA NA NA hsa-miR-200c-3p PIK3R1 2.0381485757767 1.11482598742501e-54 -1.04215691031254 2.00768909529534e-23 mirMAP -0.35699095853372 3.04024781611082e-32 NA NA NA hsa-miR-20a-5p PIK3R1 1.8613782696103 3.92351368893256e-34 -1.04215691031254 2.00768909529534e-23 MirTarget;miRNATAP -0.339677538887948 3.01379739754765e-37 NA NA NA hsa-miR-20b-5p PIK3R1 1.58314196476132 5.61327965534646e-17 -1.04215691031254 2.00768909529534e-23 MirTarget;miRNATAP -0.184186657638599 2.46073868376604e-15 NA NA NA hsa-miR-21-5p PIK3R1 1.03478217459822 8.05139001473458e-27 -1.04215691031254 2.00768909529534e-23 miRNAWalker2_validate;MirTarget;miRNATAP -0.342370148772232 3.01211254635178e-14 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 0.149472037422971 0.197699504268923 -1.04215691031254 2.00768909529534e-23 mirMAP -0.182955093611147 4.81218656236929e-06 NA NA NA hsa-miR-29b-3p PIK3R1 0.30584521532637 0.00477759838414942 -1.04215691031254 2.00768909529534e-23 MirTarget;miRNATAP -0.310277880829171 1.71201684357134e-13 NA NA NA hsa-miR-3065-5p PIK3R1 1.04645334963496 3.19942342920484e-08 -1.04215691031254 2.00768909529534e-23 MirTarget;mirMAP;miRNATAP -0.119039921989329 1.09759127888936e-06 NA NA NA hsa-miR-320a PIK3R1 0.995486653328461 1.19389676663043e-20 -1.04215691031254 2.00768909529534e-23 miRNATAP -0.284836646321351 5.62882323204054e-12 NA NA NA hsa-miR-335-3p PIK3R1 0.625191833097361 1.64208673352826e-06 -1.04215691031254 2.00768909529534e-23 mirMAP -0.155508647106449 1.01116382102673e-05 NA NA NA hsa-miR-3607-3p PIK3R1 1.16606393006353 2.28951370382033e-07 -1.04215691031254 2.00768909529534e-23 MirTarget;miRNATAP -0.117292104798819 5.88786614234328e-09 NA NA NA hsa-miR-361-5p PIK3R1 0.65220098099292 2.23302456529998e-21 -1.04215691031254 2.00768909529534e-23 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.466886585192103 5.40787420551156e-13 NA NA NA hsa-miR-374a-3p PIK3R1 0.613148065516 1.92239481728524e-11 -1.04215691031254 2.00768909529534e-23 MirTarget;miRNATAP -0.230196029068846 4.15337628253294e-06 NA NA NA hsa-miR-429 PIK3R1 0.682420529994948 0.00462213397220855 -1.04215691031254 2.00768909529534e-23 mirMAP;miRNATAP -0.0514390016640538 0.00756814867404199 NA NA NA hsa-miR-485-3p PIK3R1 0.378196908999646 0.0116649746326721 -1.04215691031254 2.00768909529534e-23 mirMAP -0.121108447508938 0.000111685584178803 NA NA NA hsa-miR-491-5p PIK3R1 0.996821208926168 6.43686029153552e-11 -1.04215691031254 2.00768909529534e-23 miRanda -0.163786520426654 3.90790186912974e-08 NA NA NA hsa-miR-495-3p PIK3R1 0.627906813412205 1.45002911833628e-07 -1.04215691031254 2.00768909529534e-23 mirMAP -0.130706442745323 0.000711948958189373 NA NA NA hsa-miR-497-5p PIK3R1 0.424937624679998 8.43432731476407e-05 -1.04215691031254 2.00768909529534e-23 MirTarget -0.202140335815885 2.19667949260122e-06 NA NA NA hsa-miR-532-3p PIK3R1 0.770066629498829 6.77162597488311e-10 -1.04215691031254 2.00768909529534e-23 MirTarget -0.181309705954334 6.77961138327403e-07 NA NA NA hsa-miR-582-5p PIK3R1 0.306116891157887 0.0402663500947974 -1.04215691031254 2.00768909529534e-23 mirMAP -0.148640226277133 1.58059079562162e-06 NA NA NA hsa-miR-584-5p PIK3R1 0.529353740475271 5.69276295507735e-06 -1.04215691031254 2.00768909529534e-23 mirMAP -0.150314545874733 0.000145230391693793 NA NA NA hsa-miR-590-3p PIK3R1 0.58484153433625 1.6489232844135e-06 -1.04215691031254 2.00768909529534e-23 miRanda;mirMAP -0.2280176196827 1.13743909079153e-09 NA NA NA hsa-miR-590-5p PIK3R1 0.778106902153171 1.13576371947662e-09 -1.04215691031254 2.00768909529534e-23 MirTarget;PITA;miRanda;miRNATAP -0.259560390329464 1.57602239382652e-13 NA NA NA hsa-miR-629-3p PIK3R1 1.01531686151469 1.96827867612758e-09 -1.04215691031254 2.00768909529534e-23 MirTarget -0.171691233470336 5.51256447973633e-10 NA NA NA hsa-miR-93-5p PIK3R1 2.02673564951392 4.11722430511325e-49 -1.04215691031254 2.00768909529534e-23 MirTarget;miRNATAP -0.373710929218136 6.65197864787337e-39 NA NA NA hsa-miR-96-5p PIK3R1 2.57339472553563 5.77311209747788e-53 -1.04215691031254 2.00768909529534e-23 TargetScan;miRNATAP -0.331158657083551 1.47927896569826e-47 NA NA NA hsa-miR-133a-3p PIK3R2 -0.593956710502213 0.000305971128010396 0.33913241591056 5.06164009636198e-10 miRNAWalker2_validate -0.0983104837373464 2.04674859773669e-12 NA NA NA hsa-miR-181c-5p PIK3R3 -0.216106163143199 0.0372442927577819 0.285024862926023 0.000913447795061982 MirTarget;miRNATAP -0.113952098521118 0.00134065139572327 NA NA NA hsa-miR-26a-5p PIK3R3 -0.255072671612558 2.10804942505211e-05 0.285024862926023 0.000913447795061982 miRNATAP -0.159106968314857 0.0104741659621156 NA NA NA hsa-miR-335-3p PIK3R3 0.625191833097361 1.64208673352826e-06 0.285024862926023 0.000913447795061982 mirMAP -0.0591092035017016 0.0348612965932354 NA NA NA hsa-miR-429 PIK3R3 0.682420529994948 0.00462213397220855 0.285024862926023 0.000913447795061982 miRNATAP -0.0744801073310764 8.02534316251342e-07 NA NA NA hsa-miR-582-5p PIK3R3 0.306116891157887 0.0402663500947974 0.285024862926023 0.000913447795061982 PITA -0.0504036300609507 0.0410184553404996 NA NA NA hsa-miR-9-5p PIK3R3 1.13944963456975 4.52386797543086e-07 0.285024862926023 0.000913447795061982 miRNATAP -0.0617211015168722 0.00011830229225316 NA NA NA hsa-let-7f-1-3p PPP3CA 0.159920578752557 0.190200799823398 0.83344927334701 9.7374038484188e-13 MirTarget -0.0953316058587201 0.0241225144242747 NA NA NA hsa-let-7i-5p PPP3CA 0.509810088463201 8.99644987043388e-12 0.83344927334701 9.7374038484188e-13 miRNATAP -0.233719025213544 0.000529385240047528 NA NA NA hsa-miR-100-5p PPP3CA -0.23100708545055 0.0155610142898603 0.83344927334701 9.7374038484188e-13 MirTarget -0.195862654509847 0.000246696220671968 NA NA NA hsa-miR-145-5p PPP3CA -0.0645550892386986 0.583308140519106 0.83344927334701 9.7374038484188e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.300346993539957 1.8299296294169e-12 NA NA NA hsa-miR-338-5p PPP3CA -1.02227005954571 1.23429740086589e-09 0.83344927334701 9.7374038484188e-13 miRNATAP -0.0684331066804606 0.0228250892355914 NA NA NA hsa-miR-361-3p PPP3CA 0.577270981783865 4.74678124050281e-11 0.83344927334701 9.7374038484188e-13 MirTarget;PITA;miRNATAP -0.148785445288878 0.00957804597304472 NA NA NA hsa-miR-450b-5p PPP3CA -0.857642158166271 2.78318878314132e-06 0.83344927334701 9.7374038484188e-13 PITA;mirMAP;miRNATAP -0.0670392575931751 0.0151890914673243 NA NA NA hsa-miR-486-5p PPP3CA -0.57201125043886 0.00125387759748302 0.83344927334701 9.7374038484188e-13 miRanda -0.0935757867859702 0.00105382832823313 NA NA NA hsa-miR-502-3p PPP3CA 0.269247655104258 0.011082474452809 0.83344927334701 9.7374038484188e-13 MirTarget;PITA;miRNATAP -0.0949249884501553 0.0491420276843661 NA NA NA hsa-miR-10b-5p PPP3CB 0.833433858224828 5.14196469408274e-10 -0.436634716741299 3.65925621942245e-19 miRNAWalker2_validate -0.062201553089019 7.46110798224926e-05 NA NA NA hsa-miR-140-5p PPP3CB 0.71404697529503 8.18104415848614e-20 -0.436634716741299 3.65925621942245e-19 miRanda -0.156471473815849 2.79449596025257e-09 NA NA NA hsa-miR-146b-5p PPP3CB 1.70281490248323 9.08060943822639e-35 -0.436634716741299 3.65925621942245e-19 miRanda -0.112859209986822 1.53173291613814e-15 NA NA NA hsa-miR-15a-5p PPP3CB 0.922713188178758 6.51407511505232e-18 -0.436634716741299 3.65925621942245e-19 miRNATAP -0.185221995072804 4.09049906807608e-23 NA NA NA hsa-miR-15b-5p PPP3CB 0.902378373341056 1.5233897847618e-20 -0.436634716741299 3.65925621942245e-19 miRNATAP -0.175115871365946 3.53870553393623e-17 NA NA NA hsa-miR-16-5p PPP3CB 0.54730888568038 1.14657883125954e-10 -0.436634716741299 3.65925621942245e-19 miRNATAP -0.21973382596629 1.07782667597209e-19 NA NA NA hsa-miR-20a-3p PPP3CB 1.93545996942606 5.86749215003338e-31 -0.436634716741299 3.65925621942245e-19 miRNATAP -0.101503687459132 4.92635066339163e-18 NA NA NA hsa-miR-26b-5p PPP3CB 0.737437044119261 6.43607077095392e-18 -0.436634716741299 3.65925621942245e-19 MirTarget;miRNATAP -0.178041765378136 1.07643750100993e-13 NA NA NA hsa-miR-3065-5p PPP3CB 1.04645334963496 3.19942342920484e-08 -0.436634716741299 3.65925621942245e-19 mirMAP -0.0773826411849183 3.65355118752113e-12 NA NA NA hsa-miR-30c-5p PPP3CB 0.746747513281495 1.32431877874944e-12 -0.436634716741299 3.65925621942245e-19 miRNATAP -0.111668111648749 1.71419731425503e-08 NA NA NA hsa-miR-30d-5p PPP3CB 0.804765144490428 1.42480384315657e-16 -0.436634716741299 3.65925621942245e-19 miRNATAP -0.171579217788215 2.40469246036271e-16 NA NA NA hsa-miR-320a PPP3CB 0.995486653328461 1.19389676663043e-20 -0.436634716741299 3.65925621942245e-19 miRanda -0.0902455154135265 2.86383157460102e-06 NA NA NA hsa-miR-320b PPP3CB 0.588484324371412 9.31703617590329e-06 -0.436634716741299 3.65925621942245e-19 miRanda -0.0500569567641078 0.00184772463644408 NA NA NA hsa-miR-339-5p PPP3CB 0.986556478524229 2.39294233177816e-12 -0.436634716741299 3.65925621942245e-19 miRanda -0.130980410650923 1.20345159219847e-19 NA NA NA hsa-miR-340-5p PPP3CB 0.418767158937086 8.44911569437093e-06 -0.436634716741299 3.65925621942245e-19 MirTarget -0.0751662705958604 0.000951404338876493 NA NA NA hsa-miR-342-3p PPP3CB 1.25856075011434 9.50396545654544e-34 -0.436634716741299 3.65925621942245e-19 miRanda -0.159051786559851 3.68157860180197e-17 NA NA NA hsa-miR-361-5p PPP3CB 0.65220098099292 2.23302456529998e-21 -0.436634716741299 3.65925621942245e-19 miRanda -0.201690552025875 1.56906147188922e-11 NA NA NA hsa-miR-497-5p PPP3CB 0.424937624679998 8.43432731476407e-05 -0.436634716741299 3.65925621942245e-19 miRNATAP -0.096805306441168 8.52033210964539e-07 NA NA NA hsa-miR-590-3p PPP3CB 0.58484153433625 1.6489232844135e-06 -0.436634716741299 3.65925621942245e-19 miRanda -0.11476140904113 2.54214136554794e-11 NA NA NA hsa-miR-7-1-3p PPP3CB 1.45703750327525 1.75378847810395e-30 -0.436634716741299 3.65925621942245e-19 mirMAP -0.11108237421108 1.35370455894523e-12 NA NA NA hsa-miR-101-3p PPP3R1 -0.0653697933029544 0.422342392755108 0.00125790531039183 0.975864165438133 miRNATAP -0.0507598363378372 0.0200490494532387 NA NA NA hsa-miR-139-5p PPP3R1 -0.248477989074291 0.0406493945332495 0.00125790531039183 0.975864165438133 miRanda -0.0845393619185762 3.64574536892131e-09 NA NA NA hsa-miR-181c-5p PPP3R1 -0.216106163143199 0.0372442927577819 0.00125790531039183 0.975864165438133 MirTarget;miRNATAP -0.0904826813794767 7.82786037162764e-08 NA NA NA hsa-miR-204-5p PPP3R1 -1.00950273930717 9.21834560704471e-10 0.00125790531039183 0.975864165438133 MirTarget;miRNATAP -0.0644812408151488 4.56087098397725e-10 NA NA NA hsa-miR-221-3p PPP3R1 -1.24494692780126 3.24056780178261e-20 0.00125790531039183 0.975864165438133 MirTarget;miRNATAP -0.0580799016870987 3.191970702609e-06 NA NA NA hsa-miR-222-3p PPP3R1 -0.953446345586859 1.89596390370367e-13 0.00125790531039183 0.975864165438133 MirTarget;miRNATAP -0.0808134521637539 6.66106111972315e-10 NA NA NA hsa-miR-27a-3p PPP3R1 -0.422972805377027 8.01035506212245e-07 0.00125790531039183 0.975864165438133 miRNATAP -0.0948163836137951 3.15463591585991e-06 NA NA NA hsa-miR-27b-3p PPP3R1 -0.671557822127919 5.00469777243288e-17 0.00125790531039183 0.975864165438133 miRNATAP -0.139193229841786 4.63981126038871e-11 NA NA NA hsa-miR-30a-5p PPP3R1 0.50856224391991 3.02321261664547e-06 0.00125790531039183 0.975864165438133 miRNAWalker2_validate;MirTarget;miRNATAP -0.0795589925109877 5.95262360949152e-07 NA NA NA hsa-miR-30b-5p PPP3R1 1.16764575603669 1.75395013539888e-20 0.00125790531039183 0.975864165438133 MirTarget -0.0541111370564082 5.55509292480563e-05 NA NA NA hsa-miR-30c-5p PPP3R1 0.746747513281495 1.32431877874944e-12 0.00125790531039183 0.975864165438133 MirTarget;miRNATAP -0.102624951410818 2.1698497660636e-10 NA NA NA hsa-miR-30e-5p PPP3R1 -0.0410434441382392 0.610918464525059 0.00125790531039183 0.975864165438133 MirTarget -0.0622006416156182 0.00474698439147191 NA NA NA hsa-miR-34a-5p PPP3R1 0.460660125860661 2.13400441654354e-06 0.00125790531039183 0.975864165438133 miRNAWalker2_validate -0.100956910599748 1.49019303152589e-08 NA NA NA hsa-miR-146b-5p PRKACA 1.70281490248323 9.08060943822639e-35 -0.242255583692472 1.51920033612551e-07 PITA -0.0845450686661822 1.45280677270539e-10 NA NA NA hsa-miR-374b-3p PRKACA 0.493983411218907 3.95433948907006e-06 -0.242255583692472 1.51920033612551e-07 mirMAP -0.0776483930570608 3.02732598623733e-05 NA NA NA hsa-let-7a-3p PRKACB 0.88579219922257 4.41035630133362e-17 -0.0823739195763027 0.426716632268214 MirTarget;mirMAP;miRNATAP -0.192712330657133 1.94141562161386e-06 NA NA NA hsa-let-7d-3p PRKACB 0.56331150793888 1.26410429606362e-11 -0.0823739195763027 0.426716632268214 MirTarget -0.200217208410325 0.000130203968532672 NA NA NA hsa-let-7f-1-3p PRKACB 0.159920578752557 0.190200799823398 -0.0823739195763027 0.426716632268214 MirTarget;mirMAP -0.113992861878885 0.00182300128498939 NA NA NA hsa-miR-126-5p PRKACB 0.222731872217002 0.050097821552168 -0.0823739195763027 0.426716632268214 mirMAP -0.113953519031996 0.00341117819089106 NA NA NA hsa-miR-141-3p PRKACB 1.79566520772935 2.4341426730525e-29 -0.0823739195763027 0.426716632268214 MirTarget;TargetScan;miRNATAP -0.128634710402027 7.18284634638486e-07 NA NA NA hsa-miR-16-2-3p PRKACB 0.615426607127207 4.1394319273097e-05 -0.0823739195763027 0.426716632268214 mirMAP -0.159254021561909 7.53337069446657e-08 NA NA NA hsa-miR-17-5p PRKACB 1.75236465070226 3.95158641628068e-36 -0.0823739195763027 0.426716632268214 TargetScan -0.123671778328183 2.59145279747964e-05 NA NA NA hsa-miR-182-5p PRKACB 2.57717136150548 4.94377928075077e-59 -0.0823739195763027 0.426716632268214 MirTarget;miRNATAP -0.072492136008796 0.00340605936531103 NA NA NA hsa-miR-183-5p PRKACB 2.41864571314465 9.99562656803135e-54 -0.0823739195763027 0.426716632268214 MirTarget -0.0674920675036335 0.00788743518439157 NA NA NA hsa-miR-18a-5p PRKACB 1.25716708436839 5.17098086128653e-16 -0.0823739195763027 0.426716632268214 miRNATAP -0.184313059770843 1.28096678771045e-11 NA NA NA hsa-miR-193a-3p PRKACB -0.289173667055148 0.0272788881309768 -0.0823739195763027 0.426716632268214 miRanda -0.0789594193547249 0.0194444627269908 NA NA NA hsa-miR-19a-3p PRKACB 1.31708679186777 4.80964007387826e-14 -0.0823739195763027 0.426716632268214 MirTarget;miRNATAP -0.100755461394151 4.01073335792198e-05 NA NA NA hsa-miR-19b-3p PRKACB 1.59390221063917 1.21812878827888e-26 -0.0823739195763027 0.426716632268214 miRNAWalker2_validate;MirTarget;miRNATAP -0.135701989031594 1.20596174572411e-06 NA NA NA hsa-miR-200a-3p PRKACB 0.478106750145322 0.0392078876144627 -0.0823739195763027 0.426716632268214 MirTarget;miRNATAP -0.0703649769625899 0.000202885566702177 NA NA NA hsa-miR-3065-5p PRKACB 1.04645334963496 3.19942342920484e-08 -0.0823739195763027 0.426716632268214 MirTarget -0.080642317446068 0.000535385873031032 NA NA NA hsa-miR-30d-3p PRKACB 0.917692758870644 7.72239658481305e-16 -0.0823739195763027 0.426716632268214 mirMAP -0.167411579066981 8.45742225223234e-06 NA NA NA hsa-miR-339-5p PRKACB 0.986556478524229 2.39294233177816e-12 -0.0823739195763027 0.426716632268214 miRanda -0.20270747193974 1.97614120069287e-11 NA NA NA hsa-miR-34a-5p PRKACB 0.460660125860661 2.13400441654354e-06 -0.0823739195763027 0.426716632268214 miRNATAP -0.141716386976106 0.00172694103256729 NA NA NA hsa-miR-361-5p PRKACB 0.65220098099292 2.23302456529998e-21 -0.0823739195763027 0.426716632268214 miRanda -0.235005748489607 0.000167442604954948 NA NA NA hsa-miR-362-3p PRKACB 0.332355427232084 0.0356765384646952 -0.0823739195763027 0.426716632268214 PITA;miRanda;miRNATAP -0.0784611460561219 0.00546125788156944 NA NA NA hsa-miR-362-5p PRKACB 1.31930944822897 5.90925525397455e-17 -0.0823739195763027 0.426716632268214 PITA -0.110779299136342 4.20539144600119e-05 NA NA NA hsa-miR-421 PRKACB 0.327743040046157 0.0121000429518392 -0.0823739195763027 0.426716632268214 PITA;miRanda -0.0727051199025606 0.0363375328013406 NA NA NA hsa-miR-429 PRKACB 0.682420529994948 0.00462213397220855 -0.0823739195763027 0.426716632268214 MirTarget;PITA;miRanda;miRNATAP -0.0643543136310679 0.00041263447705966 NA NA NA hsa-miR-495-3p PRKACB 0.627906813412205 1.45002911833628e-07 -0.0823739195763027 0.426716632268214 mirMAP -0.100219192287155 0.00630118851617782 NA NA NA hsa-miR-590-3p PRKACB 0.58484153433625 1.6489232844135e-06 -0.0823739195763027 0.426716632268214 MirTarget;PITA;miRanda;miRNATAP -0.12783415228426 0.000371490260625177 NA NA NA hsa-miR-590-5p PRKACB 0.778106902153171 1.13576371947662e-09 -0.0823739195763027 0.426716632268214 miRanda -0.143360060801758 2.36439692926233e-05 NA NA NA hsa-miR-7-1-3p PRKACB 1.45703750327525 1.75378847810395e-30 -0.0823739195763027 0.426716632268214 mirMAP -0.0948798826496346 0.00388829462407619 NA NA NA hsa-miR-708-3p PRKACB 1.69343810530707 2.2954130070802e-38 -0.0823739195763027 0.426716632268214 mirMAP -0.0713518942591777 0.0232934784010907 NA NA NA hsa-miR-93-5p PRKACB 2.02673564951392 4.11722430511325e-49 -0.0823739195763027 0.426716632268214 miRNAWalker2_validate -0.101122639629879 0.000523906366197976 NA NA NA hsa-miR-96-5p PRKACB 2.57339472553563 5.77311209747788e-53 -0.0823739195763027 0.426716632268214 miRNATAP -0.0902982002090104 0.000133993887875807 NA NA NA hsa-miR-1296-5p PRKAR1A 0.947744066726629 4.10646461142267e-11 -0.39544870668847 1.19814055963892e-10 miRNAWalker2_validate -0.120814022199754 1.39140530246743e-11 NA NA NA hsa-miR-141-3p PRKAR1A 1.79566520772935 2.4341426730525e-29 -0.39544870668847 1.19814055963892e-10 TargetScan -0.161226316717504 6.18750260977715e-27 NA NA NA hsa-miR-155-5p PRKAR1A 0.657127495088521 1.32358745918872e-06 -0.39544870668847 1.19814055963892e-10 miRNAWalker2_validate -0.0564006420544736 0.00364495003266644 NA NA NA hsa-miR-16-2-3p PRKAR1A 0.615426607127207 4.1394319273097e-05 -0.39544870668847 1.19814055963892e-10 mirMAP -0.125989196697103 9.63115637152665e-13 NA NA NA hsa-miR-16-5p PRKAR1A 0.54730888568038 1.14657883125954e-10 -0.39544870668847 1.19814055963892e-10 miRNAWalker2_validate -0.157717147492984 2.92459268721187e-07 NA NA NA hsa-miR-182-5p PRKAR1A 2.57717136150548 4.94377928075077e-59 -0.39544870668847 1.19814055963892e-10 miRNATAP -0.104243903583737 1.01436697669288e-12 NA NA NA hsa-miR-186-5p PRKAR1A 0.567811924899218 1.37607142180899e-13 -0.39544870668847 1.19814055963892e-10 mirMAP -0.26752336914553 9.90894333648099e-16 NA NA NA hsa-miR-192-5p PRKAR1A 0.245629178320705 0.0371144833362312 -0.39544870668847 1.19814055963892e-10 miRNAWalker2_validate -0.0895699988804596 6.98262651056358e-05 NA NA NA hsa-miR-195-3p PRKAR1A 0.598450619600341 1.01415597921415e-08 -0.39544870668847 1.19814055963892e-10 mirMAP -0.0500593929827719 0.0476707315312248 NA NA NA hsa-miR-25-3p PRKAR1A 1.48824362562014 5.9514552944441e-55 -0.39544870668847 1.19814055963892e-10 miRNAWalker2_validate -0.218294218870947 3.58001725573115e-19 NA NA NA hsa-miR-30a-5p PRKAR1A 0.50856224391991 3.02321261664547e-06 -0.39544870668847 1.19814055963892e-10 mirMAP -0.0873592352561984 0.000311481329573497 NA NA NA hsa-miR-30b-5p PRKAR1A 1.16764575603669 1.75395013539888e-20 -0.39544870668847 1.19814055963892e-10 mirMAP -0.216740760578703 3.38368767172421e-29 NA NA NA hsa-miR-30c-5p PRKAR1A 0.746747513281495 1.32431877874944e-12 -0.39544870668847 1.19814055963892e-10 mirMAP -0.226584144581004 2.57299503937738e-21 NA NA NA hsa-miR-30d-5p PRKAR1A 0.804765144490428 1.42480384315657e-16 -0.39544870668847 1.19814055963892e-10 mirMAP -0.107956346618415 4.72002527280192e-05 NA NA NA hsa-miR-30e-5p PRKAR1A -0.0410434441382392 0.610918464525059 -0.39544870668847 1.19814055963892e-10 mirMAP -0.101482616111134 0.00230106632327485 NA NA NA hsa-miR-320a PRKAR1A 0.995486653328461 1.19389676663043e-20 -0.39544870668847 1.19814055963892e-10 miRanda -0.126863600053824 1.00635648543728e-07 NA NA NA hsa-miR-342-3p PRKAR1A 1.25856075011434 9.50396545654544e-34 -0.39544870668847 1.19814055963892e-10 miRanda -0.204550975298182 1.86639388171642e-18 NA NA NA hsa-miR-590-3p PRKAR1A 0.58484153433625 1.6489232844135e-06 -0.39544870668847 1.19814055963892e-10 miRanda;mirMAP -0.157752858034 1.03113802352485e-13 NA NA NA hsa-miR-590-5p PRKAR1A 0.778106902153171 1.13576371947662e-09 -0.39544870668847 1.19814055963892e-10 miRanda -0.187507412744412 2.41119969977889e-21 NA NA NA hsa-miR-664a-3p PRKAR1A 0.771665734879281 3.09460128204919e-14 -0.39544870668847 1.19814055963892e-10 mirMAP -0.166812269255748 3.7399069228252e-11 NA NA NA hsa-miR-96-5p PRKAR1A 2.57339472553563 5.77311209747788e-53 -0.39544870668847 1.19814055963892e-10 miRNAWalker2_validate;TargetScan;miRNATAP -0.139761366337173 1.58459741554462e-24 NA NA NA hsa-let-7a-3p PRKAR2A 0.88579219922257 4.41035630133362e-17 -0.599684841982314 0.000566081173024094 mirMAP -0.4112749885159 1.41574065503368e-09 NA NA NA hsa-let-7a-5p PRKAR2A 0.810823676990504 1.01381033479571e-26 -0.599684841982314 0.000566081173024094 TargetScan -0.287052669877447 0.00237781271984737 NA NA NA hsa-miR-103a-3p PRKAR2A 1.20954748107198 5.62173682108416e-44 -0.599684841982314 0.000566081173024094 miRNAWalker2_validate -0.518752101873021 2.88882477320349e-11 NA NA NA hsa-miR-106a-5p PRKAR2A 1.76751200862602 7.79031604495348e-24 -0.599684841982314 0.000566081173024094 mirMAP -0.294991276464599 1.11447034949283e-13 NA NA NA hsa-miR-106b-5p PRKAR2A 1.03194006819592 5.97693261279744e-24 -0.599684841982314 0.000566081173024094 mirMAP -0.424753551845702 7.77290182038558e-10 NA NA NA hsa-miR-125a-5p PRKAR2A 0.0743450557019028 0.423845877863837 -0.599684841982314 0.000566081173024094 miRanda -0.311318941852581 0.00011048960066239 NA NA NA hsa-miR-140-5p PRKAR2A 0.71404697529503 8.18104415848614e-20 -0.599684841982314 0.000566081173024094 miRanda -0.292810850993789 0.00155419106149755 NA NA NA hsa-miR-146b-5p PRKAR2A 1.70281490248323 9.08060943822639e-35 -0.599684841982314 0.000566081173024094 miRanda -0.206535339715034 3.91885806361869e-05 NA NA NA hsa-miR-148a-3p PRKAR2A 1.85007671007711 2.47199960189831e-52 -0.599684841982314 0.000566081173024094 mirMAP -0.26028555112982 2.4033261752189e-06 NA NA NA hsa-miR-16-5p PRKAR2A 0.54730888568038 1.14657883125954e-10 -0.599684841982314 0.000566081173024094 miRNAWalker2_validate -0.472415008618311 4.06718463021114e-08 NA NA NA hsa-miR-17-5p PRKAR2A 1.75236465070226 3.95158641628068e-36 -0.599684841982314 0.000566081173024094 mirMAP -0.425535138498224 1.27685280509872e-18 NA NA NA hsa-miR-182-5p PRKAR2A 2.57717136150548 4.94377928075077e-59 -0.599684841982314 0.000566081173024094 mirMAP -0.287718386096338 2.3524952040186e-12 NA NA NA hsa-miR-197-3p PRKAR2A 0.949753058740866 6.25249252362886e-21 -0.599684841982314 0.000566081173024094 miRNAWalker2_validate -0.351244845041861 6.6561837068625e-07 NA NA NA hsa-miR-20a-5p PRKAR2A 1.8613782696103 3.92351368893256e-34 -0.599684841982314 0.000566081173024094 mirMAP -0.399818747676399 1.51570528525746e-19 NA NA NA hsa-miR-20b-5p PRKAR2A 1.58314196476132 5.61327965534646e-17 -0.599684841982314 0.000566081173024094 mirMAP -0.201175929106543 1.06565987104897e-07 NA NA NA hsa-miR-21-5p PRKAR2A 1.03478217459822 8.05139001473458e-27 -0.599684841982314 0.000566081173024094 mirMAP -0.207647191708639 0.00490928855163614 NA NA NA hsa-miR-25-3p PRKAR2A 1.48824362562014 5.9514552944441e-55 -0.599684841982314 0.000566081173024094 mirMAP -0.488195757997531 1.91685467874482e-12 NA NA NA hsa-miR-26b-5p PRKAR2A 0.737437044119261 6.43607077095392e-18 -0.599684841982314 0.000566081173024094 mirMAP -0.635268440154037 2.12549828231765e-14 NA NA NA hsa-miR-29a-5p PRKAR2A 0.458517912323329 0.000412683536074969 -0.599684841982314 0.000566081173024094 mirMAP -0.297141744374373 1.63615103627454e-07 NA NA NA hsa-miR-3065-5p PRKAR2A 1.04645334963496 3.19942342920484e-08 -0.599684841982314 0.000566081173024094 mirMAP -0.132435689874508 0.000761695453985376 NA NA NA hsa-miR-32-5p PRKAR2A 0.919129456898534 9.58217908368018e-12 -0.599684841982314 0.000566081173024094 mirMAP -0.211725354065552 8.94515863743877e-05 NA NA NA hsa-miR-320a PRKAR2A 0.995486653328461 1.19389676663043e-20 -0.599684841982314 0.000566081173024094 mirMAP -0.624034783465421 6.7615820678818e-22 NA NA NA hsa-miR-320b PRKAR2A 0.588484324371412 9.31703617590329e-06 -0.599684841982314 0.000566081173024094 mirMAP -0.190457322273381 0.000642648276224178 NA NA NA hsa-miR-335-5p PRKAR2A 0.960193718665196 5.23061119483499e-12 -0.599684841982314 0.000566081173024094 mirMAP -0.237403407847206 5.46552442601327e-06 NA NA NA hsa-miR-342-5p PRKAR2A 1.11340472250073 3.52646739347553e-17 -0.599684841982314 0.000566081173024094 miRNATAP -0.169467855996679 0.00219310940321232 NA NA NA hsa-miR-3607-3p PRKAR2A 1.16606393006353 2.28951370382033e-07 -0.599684841982314 0.000566081173024094 mirMAP -0.114749963160543 0.000430360109051691 NA NA NA hsa-miR-361-5p PRKAR2A 0.65220098099292 2.23302456529998e-21 -0.599684841982314 0.000566081173024094 miRanda -0.590576345257005 1.6355601058866e-08 NA NA NA hsa-miR-363-3p PRKAR2A 1.00269053441578 1.08997020195393e-10 -0.599684841982314 0.000566081173024094 mirMAP -0.189359771918292 5.52626261635062e-05 NA NA NA hsa-miR-3913-5p PRKAR2A 0.360173628140409 0.00428147059781048 -0.599684841982314 0.000566081173024094 mirMAP -0.167339604504458 0.00483434513583614 NA NA NA hsa-miR-582-3p PRKAR2A 0.693858322916386 6.21181920448093e-07 -0.599684841982314 0.000566081173024094 mirMAP -0.24263630983769 4.21221869888781e-06 NA NA NA hsa-miR-582-5p PRKAR2A 0.306116891157887 0.0402663500947974 -0.599684841982314 0.000566081173024094 miRNATAP -0.229440343331002 3.76635121812613e-06 NA NA NA hsa-miR-590-5p PRKAR2A 0.778106902153171 1.13576371947662e-09 -0.599684841982314 0.000566081173024094 mirMAP -0.29197465883062 3.08601221814157e-07 NA NA NA hsa-miR-7-1-3p PRKAR2A 1.45703750327525 1.75378847810395e-30 -0.599684841982314 0.000566081173024094 mirMAP -0.28322538790196 2.65668269090943e-07 NA NA NA hsa-miR-708-3p PRKAR2A 1.69343810530707 2.2954130070802e-38 -0.599684841982314 0.000566081173024094 mirMAP -0.253973570496619 1.42256309071692e-06 NA NA NA hsa-miR-92a-3p PRKAR2A 1.46190744132999 3.47140194919364e-41 -0.599684841982314 0.000566081173024094 mirMAP -0.416260932167481 2.69584746892505e-11 NA NA NA hsa-let-7a-3p PRKAR2B 0.88579219922257 4.41035630133362e-17 -0.35508888581294 0.00362199355080723 mirMAP -0.32362745914796 8.23510411891328e-12 NA NA NA hsa-let-7b-3p PRKAR2B 0.50689342778124 8.27914591468531e-08 -0.35508888581294 0.00362199355080723 mirMAP -0.338360223836685 3.98673012770844e-10 NA NA NA hsa-miR-200b-3p PRKAR2B 0.520479887309497 0.0201824904182445 -0.35508888581294 0.00362199355080723 TargetScan -0.110516201777142 1.65692926160419e-06 NA NA NA hsa-miR-200c-3p PRKAR2B 2.0381485757767 1.11482598742501e-54 -0.35508888581294 0.00362199355080723 miRNATAP -0.191504166543306 7.39311584627004e-08 NA NA NA hsa-miR-32-5p PRKAR2B 0.919129456898534 9.58217908368018e-12 -0.35508888581294 0.00362199355080723 miRNATAP -0.175367003168425 3.36056506474164e-06 NA NA NA hsa-miR-335-3p PRKAR2B 0.625191833097361 1.64208673352826e-06 -0.35508888581294 0.00362199355080723 mirMAP -0.11203429775981 0.00477929785359347 NA NA NA hsa-miR-361-5p PRKAR2B 0.65220098099292 2.23302456529998e-21 -0.35508888581294 0.00362199355080723 miRanda -0.180193386943388 0.0150347969599954 NA NA NA hsa-miR-429 PRKAR2B 0.682420529994948 0.00462213397220855 -0.35508888581294 0.00362199355080723 PITA;miRanda;miRNATAP -0.0950638262852485 9.55382580803986e-06 NA NA NA hsa-miR-9-5p PRKAR2B 1.13944963456975 4.52386797543086e-07 -0.35508888581294 0.00362199355080723 miRNATAP -0.0826861163098506 0.000283430980453406 NA NA NA hsa-miR-92a-3p PRKAR2B 1.46190744132999 3.47140194919364e-41 -0.35508888581294 0.00362199355080723 miRNATAP -0.253942194996896 7.66683548765842e-09 NA NA NA hsa-miR-140-3p PRKX 0.589055604093293 1.70551761364546e-15 -0.150237732779491 0.109320477372548 mirMAP -0.112935188889896 0.0340107343976356 NA NA NA hsa-miR-145-5p PRKX -0.0645550892386986 0.583308140519106 -0.150237732779491 0.109320477372548 MirTarget;miRNATAP -0.080019559456725 0.0191090395824035 NA NA NA hsa-miR-3065-5p PRKX 1.04645334963496 3.19942342920484e-08 -0.150237732779491 0.109320477372548 mirMAP -0.0545612095363681 0.00988690122738109 NA NA NA hsa-miR-375 PRKX 3.0764157413036 1.01411669962466e-67 -0.150237732779491 0.109320477372548 miRNAWalker2_validate;miRanda -0.0758949094735532 0.00012282695122808 NA NA NA hsa-miR-28-5p RELA 0.142043455520843 0.0231808012790841 0.15505861740637 0.000257963198345497 miRanda -0.06606845979557 0.0246787665438992 NA NA NA hsa-miR-19a-3p TNF 1.31708679186777 4.80964007387826e-14 -0.477199802689186 0.0372405080263446 miRTarBase -0.139921795677669 0.0104376682887069 26302825 Hsa miR 19a is associated with lymph metastasis and mediates the TNF α induced epithelial to mesenchymal transition in colorectal cancer metastasis colorectal cancer hsa-miR-203a-3p TNF 0.963509686753829 7.73777501764173e-14 -0.477199802689186 0.0372405080263446 miRTarBase -0.187396627371022 0.0116303617470131 NA NA NA hsa-miR-590-3p TNF 0.58484153433625 1.6489232844135e-06 -0.477199802689186 0.0372405080263446 miRanda -0.16096756522898 0.0439888282779784 NA NA NA hsa-miR-145-5p TNFRSF10A -0.0645550892386986 0.583308140519106 -0.105223574931782 0.42793117456439 MirTarget -0.178114982657432 0.000214529992620023 NA NA NA hsa-miR-362-3p TNFRSF10A 0.332355427232084 0.0356765384646952 -0.105223574931782 0.42793117456439 miRanda -0.111540169129436 0.00203569162581577 NA NA NA hsa-miR-361-5p TNFRSF10C 0.65220098099292 2.23302456529998e-21 -1.14232943835483 8.18387870574022e-10 miRanda -0.498513138364661 1.18795167077131e-05 NA NA NA hsa-miR-491-5p TNFRSF10C 0.996821208926168 6.43686029153552e-11 -1.14232943835483 8.18387870574022e-10 miRanda -0.147059690888255 0.00482374273994806 NA NA NA hsa-miR-146b-5p TNFRSF10D 1.70281490248323 9.08060943822639e-35 -1.0367055550314 1.78982023151101e-10 mirMAP -0.201019595021934 2.3364662978666e-05 NA NA NA hsa-miR-186-5p TNFRSF10D 0.567811924899218 1.37607142180899e-13 -1.0367055550314 1.78982023151101e-10 mirMAP -0.538757287630395 1.81345461006769e-09 NA NA NA hsa-miR-199b-5p TNFRSF10D 1.17761875205879 1.049059589835e-17 -1.0367055550314 1.78982023151101e-10 miRanda -0.152369707154757 0.00219014200997979 NA NA NA hsa-miR-26b-5p TNFRSF10D 0.737437044119261 6.43607077095392e-18 -1.0367055550314 1.78982023151101e-10 mirMAP -0.341031358469935 2.08481784385854e-05 NA NA NA hsa-miR-335-5p TNFRSF10D 0.960193718665196 5.23061119483499e-12 -1.0367055550314 1.78982023151101e-10 miRNAWalker2_validate -0.140914118728755 0.00459495293455216 NA NA NA hsa-miR-339-5p TNFRSF10D 0.986556478524229 2.39294233177816e-12 -1.0367055550314 1.78982023151101e-10 miRanda -0.163824708101987 0.000839190947478728 NA NA NA hsa-miR-340-5p TNFRSF10D 0.418767158937086 8.44911569437093e-06 -1.0367055550314 1.78982023151101e-10 mirMAP -0.277301303811215 0.000205898430643305 NA NA NA hsa-miR-590-3p TNFRSF10D 0.58484153433625 1.6489232844135e-06 -1.0367055550314 1.78982023151101e-10 miRanda -0.27772889339351 1.15973027393327e-06 NA NA NA hsa-miR-590-5p TNFRSF10D 0.778106902153171 1.13576371947662e-09 -1.0367055550314 1.78982023151101e-10 miRanda -0.317034275413859 3.77528073705993e-09 NA NA NA hsa-miR-7-1-3p TNFRSF10D 1.45703750327525 1.75378847810395e-30 -1.0367055550314 1.78982023151101e-10 mirMAP -0.352226175384095 8.91156126823023e-12 NA NA NA hsa-miR-129-5p TNFSF10 -0.664119897121714 0.00207371121658161 0.363500626154567 0.00232679865980949 miRanda -0.133464510852289 3.50910987879985e-08 NA NA NA hsa-miR-139-5p TNFSF10 -0.248477989074291 0.0406493945332495 0.363500626154567 0.00232679865980949 miRanda -0.108387371596934 0.010153881352069 NA NA NA hsa-miR-217 TNFSF10 0.647926571365963 0.000615546232893738 0.363500626154567 0.00232679865980949 miRanda -0.062430415389029 0.0203440626262866 NA NA NA hsa-miR-98-5p TNFSF10 0.285702607800674 7.70620719768962e-06 0.363500626154567 0.00232679865980949 miRNAWalker2_validate -0.383094608914119 1.76250896104902e-06 NA NA NA hsa-miR-10b-5p TP53 0.833433858224828 5.14196469408274e-10 0.207480793181269 0.0425434830082392 miRNAWalker2_validate;miRTarBase -0.0727877493919301 0.0233432854718589 NA NA NA hsa-miR-338-3p TP53 0.289775600192432 0.0820821857540425 0.207480793181269 0.0425434830082392 miRanda -0.110898154971579 2.07134346147895e-05 NA NA NA hsa-miR-381-3p TP53 -0.649936072093377 4.37359495040952e-09 0.207480793181269 0.0425434830082392 MirTarget -0.0976575083092219 0.0122977810128561 NA NA NA hsa-miR-125a-3p TRADD -0.335450161542356 0.00400908432417966 0.234816352818133 0.0099711548394384 miRanda -0.0925176245482509 0.00636006396936614 NA NA NA hsa-miR-324-3p TRADD -0.339294430945763 0.00312401775604045 0.234816352818133 0.0099711548394384 miRNATAP -0.124855637280874 0.000221422317357282 NA NA NA hsa-miR-330-5p TRAF2 -0.493301557454585 1.71135028785136e-05 0.415291978845981 2.45360237706534e-09 miRanda -0.139198494576843 7.35475808808858e-08 NA NA NA hsa-let-7e-5p XIAP 0.438407722828892 6.33224012337318e-08 -0.0504072512368126 0.417025113975429 miRNAWalker2_validate -0.0814551121701586 0.0121920679773354 NA NA NA hsa-miR-106a-5p XIAP 1.76751200862602 7.79031604495348e-24 -0.0504072512368126 0.417025113975429 miRNAWalker2_validate -0.0971314423422094 5.88524993896077e-12 NA NA NA hsa-miR-106b-5p XIAP 1.03194006819592 5.97693261279744e-24 -0.0504072512368126 0.417025113975429 miRNATAP -0.0755834375070797 0.00228272018257772 NA NA NA hsa-miR-125b-5p XIAP 0.0293874305780122 0.763949843010169 -0.0504072512368126 0.417025113975429 miRNAWalker2_validate -0.110130009916392 4.64619702551912e-05 NA NA NA hsa-miR-140-3p XIAP 0.589055604093293 1.70551761364546e-15 -0.0504072512368126 0.417025113975429 mirMAP -0.130983054926184 0.000182814452487427 NA NA NA hsa-miR-146b-5p XIAP 1.70281490248323 9.08060943822639e-35 -0.0504072512368126 0.417025113975429 mirMAP;miRNATAP -0.0794312361039594 7.7050472470511e-06 NA NA NA hsa-miR-149-5p XIAP 0.653969866006383 3.97144325806503e-05 -0.0504072512368126 0.417025113975429 MirTarget -0.0783050325628416 1.70308762145533e-06 NA NA NA hsa-miR-155-5p XIAP 0.657127495088521 1.32358745918872e-06 -0.0504072512368126 0.417025113975429 MirTarget -0.0588857161508237 0.00222105236553129 26779627 Bioinformatic predictions the dual-luciferase reporter assay and western blot analysis were used to detect how miR-155 regulates X-linked inhibitor of apoptosis protein XIAP; Furthermore the results from the luciferase assays and western blot analysis identified XIAP as the direct target of miR-155; In addition introducing XIAP cDNA without a three prime untranslated region 3'-UTR rescued the miR-155 promotion of apoptosis; These results indicate that miR-155 mediates cisplatin-induced apoptosis by targeting XIAP in ovarian cancer cells and that miR-155 could be a potential therapeutic target to increase the efficiency of ovarian cancer interventions ovarian cancer hsa-miR-16-1-3p XIAP 0.6666012357419 1.32179543917662e-06 -0.0504072512368126 0.417025113975429 mirMAP -0.0642781856974218 0.000779387132545619 NA NA NA hsa-miR-16-2-3p XIAP 0.615426607127207 4.1394319273097e-05 -0.0504072512368126 0.417025113975429 mirMAP -0.0879269294745219 7.17134014105918e-07 NA NA NA hsa-miR-17-5p XIAP 1.75236465070226 3.95158641628068e-36 -0.0504072512368126 0.417025113975429 miRNAWalker2_validate;TargetScan -0.0850934873298019 1.20763281743082e-06 NA NA NA hsa-miR-181a-2-3p XIAP 0.17233111979139 0.0620577531562463 -0.0504072512368126 0.417025113975429 mirMAP -0.0564916368558667 0.0498659877605033 NA NA NA hsa-miR-181a-5p XIAP 0.3456964236223 0.000458417065949141 -0.0504072512368126 0.417025113975429 miRNAWalker2_validate;miRTarBase;mirMAP -0.106319063652179 6.73337584496622e-05 NA NA NA hsa-miR-181c-5p XIAP -0.216106163143199 0.0372442927577819 -0.0504072512368126 0.417025113975429 mirMAP -0.111759293214082 1.08275627224123e-05 NA NA NA hsa-miR-186-5p XIAP 0.567811924899218 1.37607142180899e-13 -0.0504072512368126 0.417025113975429 MirTarget;miRNATAP -0.10460674470011 0.0020420090428063 NA NA NA hsa-miR-195-3p XIAP 0.598450619600341 1.01415597921415e-08 -0.0504072512368126 0.417025113975429 mirMAP -0.0802256271328947 0.00134489733698898 NA NA NA hsa-miR-19a-3p XIAP 1.31708679186777 4.80964007387826e-14 -0.0504072512368126 0.417025113975429 mirMAP -0.0861367695623582 3.187929844011e-09 NA NA NA hsa-miR-19b-1-5p XIAP 1.2422681534557 6.2822395141178e-20 -0.0504072512368126 0.417025113975429 MirTarget -0.0662724060235772 0.000394569966257652 NA NA NA hsa-miR-19b-3p XIAP 1.59390221063917 1.21812878827888e-26 -0.0504072512368126 0.417025113975429 mirMAP -0.10962961309634 3.57251005069502e-11 NA NA NA hsa-miR-20a-5p XIAP 1.8613782696103 3.92351368893256e-34 -0.0504072512368126 0.417025113975429 miRNATAP -0.0802474661998293 5.83462922831782e-07 NA NA NA hsa-miR-27a-3p XIAP -0.422972805377027 8.01035506212245e-07 -0.0504072512368126 0.417025113975429 miRNATAP -0.154098454041076 4.32081204287178e-07 26662313 miR 27a regulates the sensitivity of breast cancer cells to cisplatin treatment via BAK SMAC/DIABLO XIAP axis; After further investigation we indicated that the knockdown of miR-27a promoted the apoptosis via mitochondrial pathway in T-47D cells treated with CDDP depending on the BAK-second mitochondria-derived activator of caspase/direct IAP binding protein with low pI SMAC/DIABLO-X-linked inhibitor of apoptosis XIAP axis breast cancer hsa-miR-27b-3p XIAP -0.671557822127919 5.00469777243288e-17 -0.0504072512368126 0.417025113975429 miRNATAP -0.193855160327994 1.13678470965981e-09 NA NA NA hsa-miR-28-3p XIAP 0.464592918249577 2.99677077334997e-12 -0.0504072512368126 0.417025113975429 mirMAP;miRNATAP -0.105743148200822 0.0073233056015478 NA NA NA hsa-miR-29a-5p XIAP 0.458517912323329 0.000412683536074969 -0.0504072512368126 0.417025113975429 mirMAP -0.103247144234683 2.79579682349797e-07 NA NA NA hsa-miR-3065-5p XIAP 1.04645334963496 3.19942342920484e-08 -0.0504072512368126 0.417025113975429 mirMAP -0.0768762758032395 2.56043485078223e-08 NA NA NA hsa-miR-320a XIAP 0.995486653328461 1.19389676663043e-20 -0.0504072512368126 0.417025113975429 MirTarget;miRanda;miRNATAP -0.106525864501325 7.19987520942466e-06 NA NA NA hsa-miR-337-3p XIAP 0.478962968119505 1.28994381704869e-05 -0.0504072512368126 0.417025113975429 mirMAP -0.0755756686889223 0.00157914649058006 NA NA NA hsa-miR-361-3p XIAP 0.577270981783865 4.74678124050281e-11 -0.0504072512368126 0.417025113975429 mirMAP -0.133676530632413 6.1872843161962e-06 NA NA NA hsa-miR-361-5p XIAP 0.65220098099292 2.23302456529998e-21 -0.0504072512368126 0.417025113975429 miRanda -0.191252774842289 2.57307527271576e-07 NA NA NA hsa-miR-363-3p XIAP 1.00269053441578 1.08997020195393e-10 -0.0504072512368126 0.417025113975429 mirMAP -0.0766688875449342 3.80315714992907e-06 NA NA NA hsa-miR-484 XIAP 0.968911692345786 2.45789986401578e-17 -0.0504072512368126 0.417025113975429 mirMAP -0.0642967546361985 0.004137832194621 NA NA NA hsa-miR-500a-5p XIAP 0.724031963091637 1.07520204401533e-07 -0.0504072512368126 0.417025113975429 mirMAP;miRNATAP -0.138748662264683 1.67877428836617e-13 NA NA NA hsa-miR-505-3p XIAP -0.0131535015788877 0.895567778207462 -0.0504072512368126 0.417025113975429 mirMAP -0.0677462566746974 0.0106312710287531 NA NA NA hsa-miR-532-5p XIAP 0.819279743754755 7.86212163153492e-15 -0.0504072512368126 0.417025113975429 mirMAP -0.0718172492535045 0.00334126167466287 NA NA NA hsa-miR-590-3p XIAP 0.58484153433625 1.6489232844135e-06 -0.0504072512368126 0.417025113975429 MirTarget;miRanda;mirMAP -0.0614068896351043 0.00431605749511312 NA NA NA hsa-miR-664a-3p XIAP 0.771665734879281 3.09460128204919e-14 -0.0504072512368126 0.417025113975429 mirMAP -0.101728238910451 6.01713389864293e-05 NA NA NA hsa-miR-708-3p XIAP 1.69343810530707 2.2954130070802e-38 -0.0504072512368126 0.417025113975429 mirMAP -0.0842078189914557 6.49809480821898e-06 NA NA NA