miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-5p BMP7 -0.199052001138817 0.878277241542979 0.205155019863216 0.498498426920493 miRNAWalker2_validate -0.258809976662431 0.0017758548082738 hsa-let-7b-5p CUL1 -0.199052001138817 0.878277241542979 0.0129218624687715 0.981995631753189 miRNAWalker2_validate -0.0549753707390002 0.000326220624123555 hsa-let-7b-5p E2F5 -0.199052001138817 0.878277241542979 -0.0359162560176447 0.910823844965751 miRNAWalker2_validate;MirTarget;miRNATAP -0.208792220314713 7.49186766676534e-07 hsa-miR-100-5p CUL1 -0.00806132906517831 0.993876383825125 0.0129218624687715 0.981995631753189 miRNAWalker2_validate -0.0504626168972006 1.12501628264844e-05 hsa-miR-101-3p TGFBR1 -0.140525462772132 0.906382304639665 -0.141408193828913 0.803114596838615 miRNAWalker2_validate;miRNATAP -0.226110526180146 2.07174805788194e-09 hsa-miR-103a-3p ACVR2B 0.0952235048222612 0.939840715516335 -0.152487710062183 0.689782894367425 miRNAWalker2_validate -0.0954653318105468 0.00402144649989024 hsa-miR-103a-3p RPS6KB1 0.0952235048222612 0.939840715516335 0.0179462515277296 0.972140340853137 miRNAWalker2_validate -0.13730715753257 3.30989618940789e-05 hsa-miR-106b-5p RBL2 -0.0853499657102335 0.901700669947609 -0.0695922475238753 0.906902559203765 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.263898121665047 3.64871109439286e-25 hsa-miR-106b-5p SMAD9 -0.0853499657102335 0.901700669947609 -0.345301393083487 0.0749607019655454 miRNAWalker2_validate;mirMAP -0.491436185819539 6.42844511485369e-16 hsa-miR-106b-5p ZFYVE16 -0.0853499657102335 0.901700669947609 -0.0555216392266296 0.91670112258897 miRNAWalker2_validate -0.272784835996331 3.24737511264162e-33 hsa-miR-10b-5p INHBA 0.0860066308485106 0.952735981646638 -0.00133229760725673 0.996966071744978 miRNAWalker2_validate -0.315991143995102 3.56059166646068e-09 hsa-miR-125b-5p BMPR1B -0.0598851546678105 0.945288350565791 -0.134747300369366 0.797657104320608 miRNAWalker2_validate;miRTarBase;MirTarget -0.523279943087425 3.82265313853702e-07 hsa-miR-128-3p BMPR2 -0.0716382541209697 0.906783499707385 -0.138918726013816 0.828173765385504 miRNAWalker2_validate -0.220456287512942 2.32429009664863e-15 hsa-miR-128-3p TGFBR1 -0.0716382541209697 0.906783499707385 -0.141408193828913 0.803114596838615 miRNAWalker2_validate;miRTarBase -0.157338866756433 5.76850179866576e-06 hsa-miR-1301-3p CREBBP -0.0935647712087007 0.781492825390485 -0.121528460671809 0.849036225288355 miRNAWalker2_validate -0.0590536076300618 1.60414373280026e-05 hsa-miR-130b-3p ACVR1 -0.211426879967744 0.486104856445712 -0.102018853336211 0.839021129058447 miRNAWalker2_validate;MirTarget;miRNATAP -0.105651536077817 1.89488126222222e-10 hsa-miR-130b-3p SMAD4 -0.211426879967744 0.486104856445712 -0.0337260829637342 0.952673159973339 miRNAWalker2_validate;miRNATAP -0.0969664737937125 1.91848937755898e-09 hsa-miR-130b-3p TGFBR2 -0.211426879967744 0.486104856445712 -0.0248163256603231 0.968537582777159 miRNAWalker2_validate;miRNATAP -0.355697993280506 3.73635681408915e-25 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung cancer hsa-miR-140-3p ACVR2B -0.0813609197213889 0.923953795876038 -0.152487710062183 0.689782894367425 miRNAWalker2_validate;PITA;miRNATAP -0.205812392433297 2.84498041624841e-15 hsa-miR-141-3p TGFB2 -0.179420502124191 0.83354105481228 -0.310431949258206 0.4589149484546 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.201139839320628 1.72029232417547e-08 hsa-miR-146b-5p RHOA 0.00834882458611474 0.991577009242932 0.0333557466121839 0.967744764731311 miRNAWalker2_validate;miRanda -0.0754485631965621 1.64782584676224e-09 hsa-miR-151a-5p SKP1 -0.0279196203281629 0.960899473482335 0.11984894684252 0.870895899955478 miRNAWalker2_validate -0.0670971644303372 0.00149463714411596 hsa-miR-155-5p SMAD1 -0.167418736137707 0.822294484498835 -0.0334597572408715 0.944853393720768 miRNAWalker2_validate;miRTarBase -0.0664786506143488 1.41786422621439e-05 hsa-miR-155-5p SMAD3 -0.167418736137707 0.822294484498835 -0.00805727245311783 0.987902560465751 miRNAWalker2_validate -0.161248941325708 6.88088611744894e-17 hsa-miR-155-5p SMAD4 -0.167418736137707 0.822294484498835 -0.0337260829637342 0.952673159973339 miRNAWalker2_validate -0.114314883374695 1.83733755300191e-14 hsa-miR-155-5p SMAD5 -0.167418736137707 0.822294484498835 -0.0546789038062157 0.922780020470417 miRNAWalker2_validate;miRTarBase -0.165640259153535 6.62054395693184e-23 hsa-miR-155-5p THBS1 -0.167418736137707 0.822294484498835 -0.0068816911586822 0.993224588441564 miRNAWalker2_validate;mirMAP -0.133542323510001 7.64645600006924e-06 hsa-miR-15b-5p SMAD7 0.0382341477298391 0.953925647243518 -0.050137279965961 0.913873828853954 miRNAWalker2_validate;MirTarget;miRNATAP -0.0750276409899882 1.68659210293714e-05 hsa-miR-16-5p ACVR2A -0.131938295863899 0.869419037928521 0.0348825940608202 0.925897434335883 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.182125277687158 1.840101008093e-11 hsa-miR-16-5p SMAD7 -0.131938295863899 0.869419037928521 -0.050137279965961 0.913873828853954 miRNAWalker2_validate;MirTarget;miRNATAP -0.0642016197301395 0.00206554821413058 hsa-miR-17-5p BMPR2 -0.0085894792332244 0.990927211793889 -0.138918726013816 0.828173765385504 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.169916613515935 4.71819035178939e-19 hsa-miR-17-5p RBL2 -0.0085894792332244 0.990927211793889 -0.0695922475238753 0.906902559203765 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.11529529846799 1.64112965057067e-08 hsa-miR-17-5p SMAD3 -0.0085894792332244 0.990927211793889 -0.00805727245311783 0.987902560465751 miRNAWalker2_validate -0.144062907194855 1.0396353881575e-12 hsa-miR-17-5p TGFBR2 -0.0085894792332244 0.990927211793889 -0.0248163256603231 0.968537582777159 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.344837157501155 3.26279419912174e-25 hsa-miR-17-5p THBS1 -0.0085894792332244 0.990927211793889 -0.0068816911586822 0.993224588441564 miRNAWalker2_validate -0.211166755871651 7.35327505985432e-12 hsa-miR-181b-5p EP300 0.0375130667115933 0.959555096276237 -0.0381739592699031 0.951249053975231 miRNAWalker2_validate -0.187884049605316 7.93444158362854e-15 hsa-miR-181c-5p BMPR2 -0.18121298802215 0.718350072627076 -0.138918726013816 0.828173765385504 miRNAWalker2_validate;miRNATAP -0.153556997294714 2.48251772986161e-11 hsa-miR-181d-5p EP300 -0.116844052208921 0.774221578291478 -0.0381739592699031 0.951249053975231 miRNAWalker2_validate -0.0806657047344004 0.000232482413294744 hsa-miR-182-5p SMAD4 -0.101509746042318 0.939206381321837 -0.0337260829637342 0.952673159973339 miRNAWalker2_validate -0.065780984206604 1.05695211333097e-05 23226455;23226455 MiR-182-5p also increased nuclear beta-catenin expression and while Smad4 repressed nuclear beta-catenin expression;In conclusion our data suggests that miR-182-5p plays an important role as an oncogene by knocking down RECK and Smad4 resulting in activation of the Wnt-beta-catenin signaling pathway in bladder cancer ; bladder cancer;bladder cancer hsa-miR-18a-5p SMAD3 -0.060215066151506 0.836155187457355 -0.00805727245311783 0.987902560465751 miRNAWalker2_validate -0.145191271950291 4.28063578565896e-20 hsa-miR-18a-5p SMAD4 -0.060215066151506 0.836155187457355 -0.0337260829637342 0.952673159973339 miRNAWalker2_validate -0.0635830061103925 2.8499707420967e-07 hsa-miR-18a-5p TGFBR2 -0.060215066151506 0.836155187457355 -0.0248163256603231 0.968537582777159 miRNAWalker2_validate -0.233316456798081 1.26332307500906e-18 hsa-miR-192-5p ACVR2A -0.13549863762303 0.859625790519489 0.0348825940608202 0.925897434335883 miRNAWalker2_validate;miRNATAP -0.180643941948404 2.90310004281952e-17 hsa-miR-192-5p BMPR2 -0.13549863762303 0.859625790519489 -0.138918726013816 0.828173765385504 miRNAWalker2_validate -0.0548841109872942 0.0105924162030937 hsa-miR-192-5p ID1 -0.13549863762303 0.859625790519489 -0.128748881044468 0.709093382117699 miRNAWalker2_validate -0.376309448355852 2.01378377203536e-23 hsa-miR-192-5p ID4 -0.13549863762303 0.859625790519489 -0.203766202154454 0.618845244068564 miRNAWalker2_validate -0.401382751792557 2.84729793814996e-11 hsa-miR-197-3p PPP2CA -0.16253774958271 0.828233346204688 0.0284217367477391 0.96534362029265 miRNAWalker2_validate -0.0684429042690927 6.64329770244068e-06 hsa-miR-19a-3p BMPR2 -0.00951638786771092 0.980991306004163 -0.138918726013816 0.828173765385504 miRNAWalker2_validate;MirTarget;miRNATAP -0.155870077480006 3.19291951165458e-19 hsa-miR-19a-3p TGFBR2 -0.00951638786771092 0.980991306004163 -0.0248163256603231 0.968537582777159 miRNAWalker2_validate;miRNATAP -0.295433323573397 3.17340161137166e-22 hsa-miR-19b-3p ACVR1 -0.0314903804749491 0.95913844863355 -0.102018853336211 0.839021129058447 miRNAWalker2_validate -0.120473239964941 1.98354210807315e-11 hsa-miR-19b-3p BMPR2 -0.0314903804749491 0.95913844863355 -0.138918726013816 0.828173765385504 miRNAWalker2_validate;MirTarget;miRNATAP -0.135077875250079 3.91490815909773e-10 hsa-miR-19b-3p TGFBR2 -0.0314903804749491 0.95913844863355 -0.0248163256603231 0.968537582777159 miRNAWalker2_validate;miRNATAP -0.23529469963531 5.83073772392392e-10 hsa-miR-200a-3p SMAD3 -0.192839143060886 0.77994979695622 -0.00805727245311783 0.987902560465751 miRNAWalker2_validate -0.0959665084573349 5.0161067163894e-10 hsa-miR-200b-3p EP300 -0.109983892590611 0.891357972128093 -0.0381739592699031 0.951249053975231 miRNAWalker2_validate;TargetScan -0.0525756044353262 0.00290527970960469 hsa-miR-200c-3p RHOA -0.0449560636499466 0.969433069399071 0.0333557466121839 0.967744764731311 miRNAWalker2_validate;MirTarget;miRNATAP -0.0617829868328387 5.83761671382278e-10 hsa-miR-20a-5p BMPR2 0.0648697217907399 0.924634007033878 -0.138918726013816 0.828173765385504 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.249993991973903 3.35999987947366e-38 hsa-miR-20a-5p RBL2 0.0648697217907399 0.924634007033878 -0.0695922475238753 0.906902559203765 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.182553356518434 3.46682203211793e-18 hsa-miR-20a-5p TGFBR2 0.0648697217907399 0.924634007033878 -0.0248163256603231 0.968537582777159 miRNAWalker2_validate;miRTarBase;miRNATAP -0.346418250547717 1.79003902635661e-23 hsa-miR-20a-5p THBS1 0.0648697217907399 0.924634007033878 -0.0068816911586822 0.993224588441564 miRNAWalker2_validate -0.30952947364433 1.36418642869234e-22 hsa-miR-21-5p BMPR2 0.0148493782366828 0.992419670576308 -0.138918726013816 0.828173765385504 miRNAWalker2_validate;miRTarBase;MirTarget -0.217097837256464 4.31156278024056e-20 hsa-miR-21-5p MYC 0.0148493782366828 0.992419670576308 0.0371115296700548 0.951416673961988 miRNAWalker2_validate -0.270190862069706 5.76701615920235e-10 hsa-miR-21-5p SP1 0.0148493782366828 0.992419670576308 -0.0580656653051959 0.929748914906324 miRNAWalker2_validate;miRTarBase -0.155768447861795 3.88544448292272e-22 hsa-miR-21-5p TGFBR2 0.0148493782366828 0.992419670576308 -0.0248163256603231 0.968537582777159 miRNAWalker2_validate;miRTarBase;miRNATAP -0.537594809270263 3.47307989185754e-40 hsa-miR-21-5p ZFYVE16 0.0148493782366828 0.992419670576308 -0.0555216392266296 0.91670112258897 miRNAWalker2_validate -0.0928311994326916 5.39959332859756e-05 hsa-miR-222-3p PPP2R1A -0.0901542670760289 0.851836230793884 0.0981760857696141 0.894638367692319 miRNAWalker2_validate -0.0927977383263943 2.69520975624089e-09 hsa-miR-222-3p ZFYVE16 -0.0901542670760289 0.851836230793884 -0.0555216392266296 0.91670112258897 miRNAWalker2_validate;MirTarget -0.128742702721979 1.72908845541641e-11 hsa-miR-23b-3p E2F4 -0.158093770583088 0.851138252196472 0.0656801932693041 0.894347930127804 miRNAWalker2_validate -0.0685637543636747 0.000271264898896509 hsa-miR-25-3p EP300 0.0550592306329012 0.962829613775088 -0.0381739592699031 0.951249053975231 miRNAWalker2_validate -0.101950779775411 0.00585001386907759 hsa-miR-25-3p SMAD7 0.0550592306329012 0.962829613775088 -0.050137279965961 0.913873828853954 miRNAWalker2_validate;MirTarget;miRNATAP -0.0934659404648546 0.000435002644220941 23435373;23435373 MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7;These results suggest that miR-25 may function as a tumor suppressor by targeting Smad7 in colon cancer ; colorectal cancer;colorectal cancer hsa-miR-26a-5p SMAD1 -0.0558466394626773 0.953979749143751 -0.0334597572408715 0.944853393720768 miRNAWalker2_validate;miRTarBase;MirTarget -0.0829354823513933 0.00413714078544906 hsa-miR-26b-5p BMP8B -0.165683456923659 0.842739329770527 -0.353923600213929 0.116867182670808 miRNAWalker2_validate -0.157111125503936 0.00962756270933669 hsa-miR-26b-5p RPS6KB2 -0.165683456923659 0.842739329770527 0.246517832398615 0.597989475555673 miRNAWalker2_validate -0.119704281563459 0.00031805074232755 hsa-miR-27a-3p SP1 -0.0713791016390708 0.936296470694396 -0.0580656653051959 0.929748914906324 miRNAWalker2_validate;miRTarBase -0.116008129999336 8.74979285561679e-09 22407812;22941571;22553354;18006846;18006846 The BA-induced Sp1 Sp3 and Sp4 downregulation was accompanied by increased zinc finger ZBTB10 expression a putative Sp-repressor and decreased microRNA-27a levels a microRNA involved in the regulation of ZBTB10;Pg extract significantly decreased Sp1 Sp3 and Sp4 as well as miR-27a in BT474 and MDA-MB-231 cells and increased expression of the transcriptional repressor ZBTB10;Betulinic acid-dependent repression of Sp1 Sp3 Sp4 and Sp-regulated genes was due in part to induction of the Sp repressor ZBTB10 and downregulation of microRNA-27a miR-27a which constitutively inhibits ZBTB10 expression and we show for the first time that the effects of betulinic acid on the miR-27a:ZBTB10-Sp transcription factor axis were cannabinoid 1 CB1 and CB2 receptor-dependent thus identifying a new cellular target for this anticancer agent;Sp1 Sp3 and Sp4 are expressed in a panel of estrogen receptor ER-positive and ER-negative breast cancer cell lines and we hypothesized that regulation of their expression may be due to microRNA-27a miR-27a which is also expressed in these cell lines and has been reported to regulate the zinc finger ZBTB10 gene a putative Sp repressor;Transfection of ER-negative MDA-MB-231 breast cancer cells with antisense miR-27a as-miR-27a resulted in increased expression of ZBTB10 mRNA and decreased expression of Sp1 Sp3 and Sp4 at the mRNA and protein levels and also decreased activity in cells transfected with constructs containing Sp1 and Sp3 promoter inserts ;;;; breast cancer;breast cancer;breast cancer;breast cancer;breast cancer hsa-miR-29a-3p TGFB3 -0.173904473376583 0.873886834369773 0.111124424488611 0.835380319895798 miRNAWalker2_validate -0.215592947893623 1.26387377494944e-06 hsa-miR-30a-5p MAPK1 -0.315304933842571 0.81611555406281 -0.0485161469138511 0.940405206700101 miRNAWalker2_validate;mirMAP -0.0506304277109288 0.000298347832601506 hsa-miR-30a-5p THBS1 -0.315304933842571 0.81611555406281 -0.0068816911586822 0.993224588441564 miRNAWalker2_validate -0.0785757105082996 0.00521484715450712 hsa-miR-30d-5p SMAD1 0.00512174341017158 0.996390931509314 -0.0334597572408715 0.944853393720768 miRNAWalker2_validate;miRTarBase -0.0764180822593594 0.00278102139347393 hsa-miR-324-3p ID4 -0.0533960575545418 0.892365633037602 -0.203766202154454 0.618845244068564 miRNAWalker2_validate;PITA -0.276969829786112 3.25522149805004e-05 hsa-miR-335-5p E2F5 -0.0216107337976461 0.95157247156319 -0.0359162560176447 0.910823844965751 miRNAWalker2_validate -0.122773312196824 1.03172977893697e-07 hsa-miR-335-5p THBS3 -0.0216107337976461 0.95157247156319 -0.0219496012565683 0.964415986497255 miRNAWalker2_validate -0.0650813037249384 1.68011681983643e-05 hsa-miR-340-5p ID4 0.0820090452273905 0.816484190854532 -0.203766202154454 0.618845244068564 miRNAWalker2_validate -0.248120227632158 0.000292569442494505 hsa-miR-342-3p BMP7 -0.244092268513731 0.741215180994683 0.205155019863216 0.498498426920493 miRNAWalker2_validate;miRTarBase;miRanda -0.39939088547044 1.28747468011685e-11 hsa-miR-34a-5p MYC -0.00150684423480296 0.998107346259152 0.0371115296700548 0.951416673961988 miRNAWalker2_validate;miRTarBase -0.216308870548993 0.000129276161670072 22235332;22235332;22235332;22235332;22159222;22159222;22159222;22159222 MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells;miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays;Overexpression of c-Myc reversed miR-34a suppression of RhoA expression suggesting that miR-34a inhibits invasion by suppressing RhoA through c-Myc miR-34a was also found to repress c-Myc-pTEFB transcription elongation complex indicating one of the mechanisms by which miR-34a has profound effects on cellular function;This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex;MicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma;miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays;Overexpression of c-Myc reversed miR-34a suppression of RhoA expression and inhibition of cell invasion suggesting that miR-34a inhibits invasion by suppressing RhoA through c-Myc miR-34a was also found to repress the c-Myc-P-TEFb transcription elongation complex indicating one of the mechanisms by which miR-34a has profound effects on cellular functions;Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc ;;invasion;;;malignant trasformation;;;invasion;; prostate cancer;prostate cancer;prostate cancer;prostate cancer;renal cell cancer;renal cell cancer;renal cell cancer;renal cell cancer hsa-miR-374a-5p EP300 -0.0192159163584709 0.965315201402842 -0.0381739592699031 0.951249053975231 miRNAWalker2_validate;mirMAP -0.0752319290612454 0.0339637722000329 hsa-miR-375 CDKN2B 0.324254910768071 0.784908661939924 0.0676204813199117 0.875382601126992 miRNAWalker2_validate;miRNATAP -0.0586193388193101 0.000905778813541901 hsa-miR-375 TGFB2 0.324254910768071 0.784908661939924 -0.310431949258206 0.4589149484546 miRNAWalker2_validate -0.118032596246175 1.14664596099986e-06 hsa-miR-378a-3p E2F5 -0.139261797478558 0.836238298767332 -0.0359162560176447 0.910823844965751 miRNAWalker2_validate -0.188942985347346 1.06561996595534e-10 hsa-miR-425-5p PPP2CB -0.179935054542016 0.805737521016457 0.0839352957265156 0.884120786282379 miRNAWalker2_validate -0.1434305833926 3.027811361313e-18 hsa-miR-429 EP300 -0.142589289838583 0.802317907773415 -0.0381739592699031 0.951249053975231 miRNAWalker2_validate;miRanda;miRNATAP -0.0728175718912227 3.56075984974409e-06 hsa-miR-429 MYC -0.142589289838583 0.802317907773415 0.0371115296700548 0.951416673961988 miRNAWalker2_validate -0.108453248703558 4.76591679996824e-05 21684154;21684154;21684154 miR-429 modulates the expression of c-myc in human gastric carcinoma cells;SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots;miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells ;; stomach cancer;stomach cancer;stomach cancer hsa-miR-590-3p ID4 -0.133358268237272 0.535686159072243 -0.203766202154454 0.618845244068564 miRNAWalker2_validate;miRanda -0.268807026509474 8.44097012405478e-06 hsa-miR-590-5p TGFBR2 -0.131787544750195 0.684613701486826 -0.0248163256603231 0.968537582777159 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.286652524899627 4.12566791851325e-16 hsa-miR-744-5p TGFB1 -0.117721143255717 0.775755712074427 0.093038025024498 0.85261027429208 miRNAWalker2_validate;miRNATAP -0.166126823806423 2.82828117413693e-09 hsa-miR-769-5p CREBBP -0.10362464632991 0.793365222563107 -0.121528460671809 0.849036225288355 miRNAWalker2_validate -0.0522468958915988 0.0193949621926048 hsa-miR-92a-3p BMPR2 -0.0230307937945682 0.984317735692711 -0.138918726013816 0.828173765385504 miRNAWalker2_validate;miRNATAP -0.157420472890194 1.52521487852708e-09 hsa-miR-92a-3p PPP2R1A -0.0230307937945682 0.984317735692711 0.0981760857696141 0.894638367692319 miRNAWalker2_validate -0.0541156654278205 0.00785264900927655 hsa-miR-92a-3p TGFBR2 -0.0230307937945682 0.984317735692711 -0.0248163256603231 0.968537582777159 miRNAWalker2_validate -0.223515332507838 1.18491745689284e-06 hsa-miR-92a-3p THBS1 -0.0230307937945682 0.984317735692711 -0.0068816911586822 0.993224588441564 miRNAWalker2_validate -0.236223996163107 1.60863345703223e-08 hsa-miR-92a-3p ZFYVE16 -0.0230307937945682 0.984317735692711 -0.0555216392266296 0.91670112258897 miRNAWalker2_validate -0.246794432322245 3.96039223067285e-24 hsa-miR-93-5p BMPR2 0.0554251653547535 0.959380932710413 -0.138918726013816 0.828173765385504 miRNAWalker2_validate;MirTarget;miRNATAP -0.297498916175773 3.22742453305909e-37 hsa-miR-93-5p SMAD4 0.0554251653547535 0.959380932710413 -0.0337260829637342 0.952673159973339 miRNAWalker2_validate;mirMAP;miRNATAP -0.118636275861089 1.4710971943885e-09 hsa-miR-93-5p TGFBR2 0.0554251653547535 0.959380932710413 -0.0248163256603231 0.968537582777159 miRNAWalker2_validate;miRNATAP -0.609999323446729 8.30075605455623e-52 hsa-miR-98-5p CDKN2B 0.0782917740368987 0.880173437070493 0.0676204813199117 0.875382601126992 miRNAWalker2_validate -0.143107086249608 0.00777262486006497 hsa-miR-98-5p SMAD7 0.0782917740368987 0.880173437070493 -0.050137279965961 0.913873828853954 miRNAWalker2_validate -0.0639297832647197 0.00777180437633045 hsa-miR-98-5p TGFBR1 0.0782917740368987 0.880173437070493 -0.141408193828913 0.803114596838615 miRNAWalker2_validate -0.153945603415794 5.62215521493057e-05 hsa-miR-98-5p THBS1 0.0782917740368987 0.880173437070493 -0.0068816911586822 0.993224588441564 miRNAWalker2_validate -0.196108417985267 8.06107193430326e-05 hsa-miR-29b-3p TGFB3 -0.147629200668355 0.855068431567557 0.111124424488611 0.835380319895798 miRTarBase -0.300724044682202 2.93536952356929e-15 hsa-miR-203a-3p SMAD4 -0.0587428946483168 0.955500869059044 -0.0337260829637342 0.952673159973339 miRTarBase -0.053106206691725 1.95692576866529e-08 hsa-miR-29b-3p TGFB2 -0.147629200668355 0.855068431567557 -0.310431949258206 0.4589149484546 miRTarBase;MirTarget;miRNATAP -0.435812547346718 1.64777033866721e-14 hsa-miR-106a-5p TGFBR2 -0.142040012764908 0.692192967482747 -0.0248163256603231 0.968537582777159 miRTarBase;miRNATAP -0.167004125374202 5.11178559030175e-08 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion invasion;cell migration; colorectal cancer hsa-let-7a-2-3p CHRD -0.339913368059229 0.222872773717896 0.0538554939791851 0.885642347857914 MirTarget -0.272645412472333 8.08335237089072e-11 hsa-let-7a-3p TGFB3 -0.130729276906521 0.779692030572974 0.111124424488611 0.835380319895798 MirTarget -0.23002281448221 5.95409654478238e-07 hsa-let-7a-3p ACVR1 -0.130729276906521 0.779692030572974 -0.102018853336211 0.839021129058447 MirTarget;miRNATAP -0.0699696458482312 0.00372049909034026 hsa-let-7a-3p ID1 -0.130729276906521 0.779692030572974 -0.128748881044468 0.709093382117699 MirTarget;miRNATAP -0.288666797905502 2.68339123612235e-08 hsa-let-7a-5p E2F5 -0.0656092877172174 0.961124733677684 -0.0359162560176447 0.910823844965751 MirTarget;TargetScan;miRNATAP -0.252632998058136 4.16489182218567e-06 hsa-let-7b-3p ID1 -0.287127027685606 0.565601265486799 -0.128748881044468 0.709093382117699 MirTarget;miRNATAP -0.213661368629314 5.17627112591308e-08 hsa-let-7c-5p E2F5 -0.143443180517618 0.886580802063121 -0.0359162560176447 0.910823844965751 MirTarget -0.287024192767085 1.82102078575949e-22 hsa-let-7d-5p GDF6 -0.176960380407253 0.795858406343421 0.127943908145237 0.526417832939525 MirTarget;miRNATAP -0.176724465068045 0.00771130569639958 hsa-let-7d-5p DCN -0.176960380407253 0.795858406343421 0.00731810243205899 0.993040111761826 MirTarget -0.402955453367597 1.36046683351098e-08 hsa-let-7d-5p CHRD -0.176960380407253 0.795858406343421 0.0538554939791851 0.885642347857914 MirTarget;miRNATAP -0.76923545518416 3.69579499425558e-23 hsa-let-7d-5p ACVR1C -0.176960380407253 0.795858406343421 -0.242633657325932 0.39426919694045 MirTarget;miRNATAP -0.382116715205794 0.00021701935831798 hsa-let-7e-5p ACVR1C 0.0357092208790988 0.968612511131967 -0.242633657325932 0.39426919694045 MirTarget;miRNATAP -0.391129535622582 0.000478036013006995 hsa-let-7f-1-3p TGFB3 -0.222769653030984 0.176243975299018 0.111124424488611 0.835380319895798 MirTarget -0.195594535331808 6.10557486170201e-08 hsa-let-7f-1-3p ID1 -0.222769653030984 0.176243975299018 -0.128748881044468 0.709093382117699 MirTarget -0.168472615663934 3.82568771699861e-05 hsa-let-7f-1-3p ZFYVE16 -0.222769653030984 0.176243975299018 -0.0555216392266296 0.91670112258897 MirTarget;mirMAP -0.0507342688494627 0.0191993667490172 hsa-let-7g-3p CHRD -0.39123398731129 0.399100962252738 0.0538554939791851 0.885642347857914 MirTarget -0.386082992677401 2.40311520153789e-19 hsa-let-7g-5p GDF6 -0.168556367162896 0.835060549207039 0.127943908145237 0.526417832939525 MirTarget;miRNATAP -0.211224881140262 0.00858834057253194 hsa-let-7g-5p DCN -0.168556367162896 0.835060549207039 0.00731810243205899 0.993040111761826 MirTarget -0.303726193013156 0.000445615748265266 hsa-let-7g-5p CHRD -0.168556367162896 0.835060549207039 0.0538554939791851 0.885642347857914 MirTarget;miRNATAP -0.703022574426774 1.56994154115734e-13 hsa-let-7i-5p CHRD -0.0150044050672964 0.984758993703736 0.0538554939791851 0.885642347857914 MirTarget;miRNATAP -0.941754610147491 2.05853715388535e-15 hsa-miR-1-3p E2F5 0.121677228823826 0.614674337813684 -0.0359162560176447 0.910823844965751 MirTarget -0.197646452192756 1.30207517693539e-16 hsa-miR-106a-5p RBL2 -0.142040012764908 0.692192967482747 -0.0695922475238753 0.906902559203765 MirTarget;miRNATAP -0.0694971234438588 0.000173089783181968 24045973;24045973 Among many miR-106a predicated target genes p130 RBL2 an retinoblastoma Rb tumor suppressor family member was not only confirmed as a specific target of miR-106a but also related to tumor growth and differentiation;The importance of mir-106a and RBL2 was further demonstrated in vivo in which SKOV3 cells overexpressing miR-106a formed poorly differentiated carcinomas and had reduced RBL2 levels differentiation;; ovarian cancer;ovarian cancer hsa-miR-106a-5p BMPR2 -0.142040012764908 0.692192967482747 -0.138918726013816 0.828173765385504 MirTarget;miRNATAP -0.0522940812939807 0.00286193350513584 hsa-miR-106a-5p THBS2 -0.142040012764908 0.692192967482747 0.0420384090474553 0.953596062900646 MirTarget -0.088417916212717 0.0134796794118984 hsa-miR-106b-5p SMAD5 -0.0853499657102335 0.901700669947609 -0.0546789038062157 0.922780020470417 MirTarget;miRNATAP -0.223679527076449 1.0601999123081e-23 hsa-miR-106b-5p ZFYVE9 -0.0853499657102335 0.901700669947609 -0.12199434575654 0.788138337240637 MirTarget;miRNATAP -0.185218690175619 8.52920009344294e-09 hsa-miR-106b-5p BMPR2 -0.0853499657102335 0.901700669947609 -0.138918726013816 0.828173765385504 MirTarget;miRNATAP -0.276781658266959 5.38230356337068e-31 hsa-miR-106b-5p THBS2 -0.0853499657102335 0.901700669947609 0.0420384090474553 0.953596062900646 MirTarget -0.302711566656831 1.58196287774772e-09 hsa-miR-125b-2-3p PPP2CA -0.19521949049782 0.618072714328679 0.0284217367477391 0.96534362029265 MirTarget -0.0997688568203327 6.31632051255472e-20 hsa-miR-128-3p ACVR2A -0.0716382541209697 0.906783499707385 0.0348825940608202 0.925897434335883 MirTarget -0.217582421784768 1.37517380343148e-14 hsa-miR-128-3p PPP2R1B -0.0716382541209697 0.906783499707385 -0.00522798350256881 0.991408260059311 MirTarget -0.109583188561297 0.000963818534703709 hsa-miR-130a-3p SKP1 -0.19782843294836 0.720491845034151 0.11984894684252 0.870895899955478 MirTarget -0.139641825685064 4.17514374271046e-19 hsa-miR-130b-3p SKP1 -0.211426879967744 0.486104856445712 0.11984894684252 0.870895899955478 MirTarget -0.106102178127117 1.72601795720608e-11 hsa-miR-130b-3p SMAD5 -0.211426879967744 0.486104856445712 -0.0546789038062157 0.922780020470417 MirTarget;miRNATAP -0.103519076322907 1.92070227254941e-08 hsa-miR-130b-3p ZFYVE9 -0.211426879967744 0.486104856445712 -0.12199434575654 0.788138337240637 MirTarget;miRNATAP -0.0837892178894111 0.00140460900960098 hsa-miR-130b-3p BMPR2 -0.211426879967744 0.486104856445712 -0.138918726013816 0.828173765385504 MirTarget;miRNATAP -0.132800742011577 2.36935481480511e-11 hsa-miR-130b-3p BMP6 -0.211426879967744 0.486104856445712 -0.0629624972268548 0.790089529546855 MirTarget -0.147583952017726 0.000371484950082228 hsa-miR-139-5p PPP2CA 0.00543145985495741 0.991591290852214 0.0284217367477391 0.96534362029265 MirTarget;PITA;miRanda -0.0752357615240133 2.77630014146499e-13 hsa-miR-140-3p RHOA -0.0813609197213889 0.923953795876038 0.0333557466121839 0.967744764731311 MirTarget;PITA;miRNATAP -0.0638356714059831 2.22577877353767e-06 hsa-miR-140-3p BMPR1B -0.0813609197213889 0.923953795876038 -0.134747300369366 0.797657104320608 MirTarget -0.897617718710942 1.46772814243533e-13 hsa-miR-141-3p LTBP1 -0.179420502124191 0.83354105481228 -0.0847739199441895 0.876948200966833 MirTarget -0.14099266757721 4.14111813979571e-09 hsa-miR-141-5p ZFYVE9 -0.21874832932521 0.789341690802864 -0.12199434575654 0.788138337240637 MirTarget;miRNATAP -0.10090128380654 3.27275738623532e-06 hsa-miR-142-3p ACVR2A -0.419981832465888 0.660228548488659 0.0348825940608202 0.925897434335883 MirTarget;PITA;miRanda;miRNATAP -0.0626271015168138 1.63596450013711e-05 hsa-miR-142-5p BMPR1A -0.35195621065247 0.488286772825655 -0.119520840785576 0.790693309531106 MirTarget -0.0661247064280774 0.000190466597388917 hsa-miR-142-5p BMPR2 -0.35195621065247 0.488286772825655 -0.138918726013816 0.828173765385504 MirTarget;PITA -0.0654128068870862 7.33471481594331e-05 hsa-miR-143-5p LEFTY1 -0.291325446322919 0.584981815156526 0.291529636632215 0.211479621947004 MirTarget -0.119568390843974 0.000253606509886093 hsa-miR-148a-3p SKP1 -0.184595009730559 0.892714155682155 0.11984894684252 0.870895899955478 MirTarget -0.0817626785415723 2.03052522852265e-06 hsa-miR-148a-3p NOG -0.184595009730559 0.892714155682155 -0.264314103066992 0.373098587786885 MirTarget;miRNATAP -0.160898206457741 0.00507229210468836 hsa-miR-148a-5p RPS6KB1 -0.200917166615887 0.667057353234933 0.0179462515277296 0.972140340853137 MirTarget;miRNATAP -0.171064566688249 3.39982513466234e-13 hsa-miR-148b-3p TGFB2 -0.121415535518017 0.85232232285121 -0.310431949258206 0.4589149484546 MirTarget -0.422618628558287 7.82755899138552e-11 hsa-miR-148b-3p NOG -0.121415535518017 0.85232232285121 -0.264314103066992 0.373098587786885 MirTarget -0.582391985124335 3.41820665130688e-16 hsa-miR-148b-3p ACVR1 -0.121415535518017 0.85232232285121 -0.102018853336211 0.839021129058447 MirTarget -0.102171018697993 8.03726381461303e-06 hsa-miR-149-5p TGFB2 0.110896382194027 0.854013616827913 -0.310431949258206 0.4589149484546 MirTarget;miRNATAP -0.129221359501958 7.02534131250114e-05 hsa-miR-150-5p BMPR1B -0.38061861500346 0.649699545321307 -0.134747300369366 0.797657104320608 MirTarget -0.447906956063762 1.00992000293386e-11 hsa-miR-151a-5p TGFB3 -0.0279196203281629 0.960899473482335 0.111124424488611 0.835380319895798 MirTarget -0.460270915838936 5.41462985077644e-29 hsa-miR-152-3p SKP1 -0.0912672611791701 0.896838779751061 0.11984894684252 0.870895899955478 MirTarget -0.0643040290937307 0.00305236087981287 hsa-miR-154-5p E2F5 -0.261890310803176 0.26439362899773 -0.0359162560176447 0.910823844965751 MirTarget;miRNATAP -0.129030803814152 8.20733931583736e-06 hsa-miR-155-5p RPS6KB1 -0.167418736137707 0.822294484498835 0.0179462515277296 0.972140340853137 MirTarget -0.0603254623315925 0.00294866114835547 hsa-miR-15a-5p ACVR2A 0.027476192963463 0.965257307327948 0.0348825940608202 0.925897434335883 MirTarget;miRNATAP -0.36516801924186 2.81837633955843e-37 hsa-miR-15a-5p PPP2R1B 0.027476192963463 0.965257307327948 -0.00522798350256881 0.991408260059311 MirTarget -0.195736754254626 1.30304715741401e-08 hsa-miR-15a-5p SMAD7 0.027476192963463 0.965257307327948 -0.050137279965961 0.913873828853954 MirTarget;miRNATAP -0.0741811300217101 0.00111689664917535 hsa-miR-15a-5p SMAD5 0.027476192963463 0.965257307327948 -0.0546789038062157 0.922780020470417 MirTarget;miRNATAP -0.28309402402264 8.1950679424613e-27 hsa-miR-15a-5p SMAD3 0.027476192963463 0.965257307327948 -0.00805727245311783 0.987902560465751 MirTarget -0.127238885845652 3.99211956272264e-05 hsa-miR-15a-5p SMURF1 0.027476192963463 0.965257307327948 -0.0283488722311267 0.955235001401958 MirTarget;miRNATAP -0.0811105149013537 5.64769385864137e-05 hsa-miR-15b-5p ACVR2A 0.0382341477298391 0.953925647243518 0.0348825940608202 0.925897434335883 MirTarget;miRNATAP -0.16858903260967 1.0459646769634e-13 hsa-miR-15b-5p SMAD5 0.0382341477298391 0.953925647243518 -0.0546789038062157 0.922780020470417 MirTarget;miRNATAP -0.0781802896177451 0.000181701100821108 hsa-miR-15b-5p SMAD3 0.0382341477298391 0.953925647243518 -0.00805727245311783 0.987902560465751 MirTarget -0.103829420518863 1.25324379645245e-05 hsa-miR-16-1-3p THBS1 -0.172993537212073 0.391863504419512 -0.0068816911586822 0.993224588441564 MirTarget -0.140131478293771 0.000198601030104097 hsa-miR-16-1-3p ROCK1 -0.172993537212073 0.391863504419512 -0.172548975888922 0.760861741105756 MirTarget -0.0869540296169407 0.000855200324506474 hsa-miR-16-2-3p ID1 -0.107555719075227 0.702302679752719 -0.128748881044468 0.709093382117699 MirTarget -0.106045291832553 0.00490760564452169 hsa-miR-17-3p PPP2CA -0.00462206849027691 0.994608252674318 0.0284217367477391 0.96534362029265 MirTarget -0.133330530645377 1.5958296816568e-20 hsa-miR-17-5p SMAD5 -0.0085894792332244 0.990927211793889 -0.0546789038062157 0.922780020470417 MirTarget;TargetScan;miRNATAP -0.130886886030224 1.5069406772606e-13 22326755 We found a negative correlation between miR-17-5p and its two predicted targets VEGF-A and EGLN3 and between miR-224 and its targets SMAD4 and SMAD5 in RCC specimens suggesting that downstream signaling pathways are also modulated by clear cell RCC-dysregulated miRs renal cell cancer hsa-miR-17-5p THBS2 -0.0085894792332244 0.990927211793889 0.0420384090474553 0.953596062900646 MirTarget;TargetScan -0.253625690199161 1.06814941199192e-10 hsa-miR-181a-5p ACVR2A 0.0637093750406734 0.945876131429707 0.0348825940608202 0.925897434335883 MirTarget;miRNATAP -0.0785162744705962 0.00430936613101197 hsa-miR-181a-5p RPS6KB1 0.0637093750406734 0.945876131429707 0.0179462515277296 0.972140340853137 MirTarget;miRNATAP -0.130436776786364 8.76017102192071e-06 hsa-miR-181a-5p DCN 0.0637093750406734 0.945876131429707 0.00731810243205899 0.993040111761826 MirTarget -0.252752904906497 0.000128654659180327 hsa-miR-181b-5p ACVR2A 0.0375130667115933 0.959555096276237 0.0348825940608202 0.925897434335883 MirTarget;miRNATAP -0.115588398670053 5.65233109391086e-07 hsa-miR-181b-5p RPS6KB1 0.0375130667115933 0.959555096276237 0.0179462515277296 0.972140340853137 MirTarget;miRNATAP -0.0846180440569936 0.000654273354698135 hsa-miR-181b-5p DCN 0.0375130667115933 0.959555096276237 0.00731810243205899 0.993040111761826 MirTarget -0.396219797750911 6.579807345297e-13 hsa-miR-181c-5p ACVR2A -0.18121298802215 0.718350072627076 0.0348825940608202 0.925897434335883 MirTarget;miRNATAP -0.0885959915561439 0.000168930663035114 hsa-miR-181c-5p RPS6KB1 -0.18121298802215 0.718350072627076 0.0179462515277296 0.972140340853137 MirTarget;miRNATAP -0.186058639495696 7.95661299115965e-14 hsa-miR-181c-5p DCN -0.18121298802215 0.718350072627076 0.00731810243205899 0.993040111761826 MirTarget -0.293525013757079 1.96602577911095e-07 hsa-miR-181d-5p ACVR2A -0.116844052208921 0.774221578291478 0.0348825940608202 0.925897434335883 MirTarget -0.0864651985054809 2.94431427596755e-05 hsa-miR-181d-5p RPS6KB1 -0.116844052208921 0.774221578291478 0.0179462515277296 0.972140340853137 MirTarget -0.164885796389909 5.09783807829002e-14 hsa-miR-181d-5p DCN -0.116844052208921 0.774221578291478 0.00731810243205899 0.993040111761826 MirTarget -0.324337485034118 5.14263997474735e-11 hsa-miR-182-5p ROCK1 -0.101509746042318 0.939206381321837 -0.172548975888922 0.760861741105756 MirTarget -0.0792467059531576 0.000107199608429092 hsa-miR-182-5p ACVR1 -0.101509746042318 0.939206381321837 -0.102018853336211 0.839021129058447 MirTarget;miRNATAP -0.0897705390387439 4.3268006472444e-09 hsa-miR-183-5p PPP2CB -0.0285894962233133 0.980944848059819 0.0839352957265156 0.884120786282379 MirTarget;miRNATAP -0.0816694898012429 2.48553389599593e-09 hsa-miR-185-5p SMAD3 0.0659414824247602 0.896134370932431 -0.00805727245311783 0.987902560465751 MirTarget -0.139641114876277 4.17733017511663e-05 hsa-miR-185-5p BMPR2 0.0659414824247602 0.896134370932431 -0.138918726013816 0.828173765385504 MirTarget -0.344917833393806 4.84718132418701e-28 hsa-miR-186-5p SMAD6 -0.14779866926096 0.840248407765158 -0.00809188507489367 0.969183109415995 MirTarget -0.153046884016817 2.89903473805251e-05 hsa-miR-186-5p NOG -0.14779866926096 0.840248407765158 -0.264314103066992 0.373098587786885 MirTarget;miRNATAP -0.277056736375451 0.000125196317691307 hsa-miR-186-5p ZFYVE16 -0.14779866926096 0.840248407765158 -0.0555216392266296 0.91670112258897 MirTarget -0.121683675555525 3.02603117893438e-06 hsa-miR-18a-5p THBS1 -0.060215066151506 0.836155187457355 -0.0068816911586822 0.993224588441564 MirTarget -0.181152396860618 8.69562380186631e-14 hsa-miR-192-5p LEFTY2 -0.13549863762303 0.859625790519489 0.166294618858231 0.611364853254296 MirTarget -0.638420889641026 1.25196068350713e-15 22386240 The expression of the miR-200 family miR-205 and miR-192 in the urine sediment significantly correlated with urinary expression of EMT markers including zinc finger E-box-binding homeobox 1 vimentin transforming growth factor β1 and Ras homolog gene family member A bladder cancer hsa-miR-193a-3p TGFB2 -0.0143163678163178 0.969244019090322 -0.310431949258206 0.4589149484546 MirTarget;miRanda;miRNATAP -0.385790006047712 1.31529188795393e-11 hsa-miR-193b-3p TGFB2 -0.258193381252116 0.674998055533564 -0.310431949258206 0.4589149484546 MirTarget;miRNATAP -0.171503498781225 0.000913844156376696 hsa-miR-194-5p ZFYVE9 -0.0985657553098873 0.88041455080541 -0.12199434575654 0.788138337240637 MirTarget -0.0850394702626854 0.0313977581329141 hsa-miR-195-3p RBL1 -0.0314657373015459 0.893921960533907 -0.00762815276935669 0.980577451432883 MirTarget;mirMAP -0.136404640726563 0.000466660213562153 hsa-miR-1976 SMAD3 -0.190354496295963 0.520771411809134 -0.00805727245311783 0.987902560465751 MirTarget -0.121630671332983 6.52049342337766e-05 hsa-miR-19a-3p SMAD5 -0.00951638786771092 0.980991306004163 -0.0546789038062157 0.922780020470417 MirTarget;miRNATAP -0.126975084432939 3.71096081688784e-15 hsa-miR-19a-3p THBS1 -0.00951638786771092 0.980991306004163 -0.0068816911586822 0.993224588441564 MirTarget;mirMAP -0.214042484472341 2.35179044480412e-14 hsa-miR-19b-3p SMAD5 -0.0314903804749491 0.95913844863355 -0.0546789038062157 0.922780020470417 MirTarget;miRNATAP -0.0986960562425677 8.21648643002133e-07 hsa-miR-19b-3p THBS1 -0.0314903804749491 0.95913844863355 -0.0068816911586822 0.993224588441564 MirTarget;mirMAP -0.25361005913269 1.79395476818e-13 hsa-miR-200a-3p TGFB2 -0.192839143060886 0.77994979695622 -0.310431949258206 0.4589149484546 MirTarget;miRNATAP -0.157197308079383 7.61768751897913e-06 hsa-miR-200a-3p LTBP1 -0.192839143060886 0.77994979695622 -0.0847739199441895 0.876948200966833 MirTarget -0.155545472524258 3.39347655502809e-11 hsa-miR-200b-3p PPP2R1B -0.109983892590611 0.891357972128093 -0.00522798350256881 0.991408260059311 MirTarget -0.190114683335312 5.20726875191601e-24 hsa-miR-200b-3p RPS6KB1 -0.109983892590611 0.891357972128093 0.0179462515277296 0.972140340853137 MirTarget;TargetScan -0.0691868859572835 0.000104931236535329 hsa-miR-200b-3p NOG -0.109983892590611 0.891357972128093 -0.264314103066992 0.373098587786885 MirTarget;TargetScan -0.249677853882184 6.65837437098035e-09 hsa-miR-200c-3p PPP2R1B -0.0449560636499466 0.969433069399071 -0.00522798350256881 0.991408260059311 MirTarget -0.226923946553815 2.68646974148231e-28 hsa-miR-200c-3p NOG -0.0449560636499466 0.969433069399071 -0.264314103066992 0.373098587786885 MirTarget;miRNATAP -0.347080893351845 1.63065263678635e-13 hsa-miR-20a-3p SMAD3 -0.267112043185936 0.342386318550293 -0.00805727245311783 0.987902560465751 MirTarget -0.0519894042578679 0.00251395004716515 hsa-miR-20a-5p SMAD5 0.0648697217907399 0.924634007033878 -0.0546789038062157 0.922780020470417 MirTarget;miRNATAP -0.20427043007251 1.19685654895982e-29 hsa-miR-20a-5p ZFYVE9 0.0648697217907399 0.924634007033878 -0.12199434575654 0.788138337240637 MirTarget;miRNATAP -0.0601849326271543 0.0231192678647791 hsa-miR-20a-5p THBS2 0.0648697217907399 0.924634007033878 0.0420384090474553 0.953596062900646 MirTarget -0.342590656166951 2.95705202030977e-17 hsa-miR-20b-5p RBL2 -0.275771697228234 0.506979861341138 -0.0695922475238753 0.906902559203765 MirTarget;miRNATAP -0.061859891500619 9.78607097542936e-06 hsa-miR-20b-5p ZFYVE9 -0.275771697228234 0.506979861341138 -0.12199434575654 0.788138337240637 MirTarget;miRNATAP -0.0518568389959261 0.0027968079970339 hsa-miR-21-3p CREBBP -0.103229815917794 0.915406989389524 -0.121528460671809 0.849036225288355 MirTarget -0.0531489438597555 0.000787564088741477 hsa-miR-221-3p ZFYVE16 -0.0578227721969284 0.924067621219326 -0.0555216392266296 0.91670112258897 MirTarget -0.2315682936639 8.05151120103469e-31 hsa-miR-222-3p SKP1 -0.0901542670760289 0.851836230793884 0.11984894684252 0.870895899955478 MirTarget -0.10501825880122 4.51166430229641e-11 hsa-miR-223-3p RPS6KB1 -0.25971106178338 0.669659245147467 0.0179462515277296 0.972140340853137 MirTarget -0.140401561003547 1.98539879754319e-12 hsa-miR-26b-3p NOG -0.448241800192409 0.298334709297841 -0.264314103066992 0.373098587786885 MirTarget -0.159500347625355 0.0021102075628094 hsa-miR-26b-3p TGFB3 -0.448241800192409 0.298334709297841 0.111124424488611 0.835380319895798 MirTarget -0.166318643088715 1.09180542813277e-07 hsa-miR-27a-3p SMAD9 -0.0713791016390708 0.936296470694396 -0.345301393083487 0.0749607019655454 MirTarget;miRNATAP -0.156498842575649 0.0351039542254818 hsa-miR-27a-3p SMAD4 -0.0713791016390708 0.936296470694396 -0.0337260829637342 0.952673159973339 MirTarget -0.107318887613883 7.95509636261065e-06 hsa-miR-27a-3p RPS6KB1 -0.0713791016390708 0.936296470694396 0.0179462515277296 0.972140340853137 MirTarget;miRNATAP -0.152883993564015 2.01871224053452e-06 hsa-miR-27b-3p SMAD4 -0.113933322553999 0.889976675583125 -0.0337260829637342 0.952673159973339 MirTarget -0.0711570705796461 0.00146964697834738 hsa-miR-27b-3p RPS6KB1 -0.113933322553999 0.889976675583125 0.0179462515277296 0.972140340853137 MirTarget;miRNATAP -0.0972420536976888 0.00117945577550381 hsa-miR-29a-3p THBS2 -0.173904473376583 0.873886834369773 0.0420384090474553 0.953596062900646 MirTarget -0.330180674500405 5.19990176669046e-09 hsa-miR-29b-3p THBS2 -0.147629200668355 0.855068431567557 0.0420384090474553 0.953596062900646 MirTarget -0.440296132980001 7.26973369809758e-20 hsa-miR-29b-3p ID1 -0.147629200668355 0.855068431567557 -0.128748881044468 0.709093382117699 MirTarget -0.188784664946449 1.46064015731403e-05 hsa-miR-29c-3p TGFB2 -0.0526710652467877 0.956320854458284 -0.310431949258206 0.4589149484546 MirTarget;miRNATAP -0.393270636676739 1.42982951467692e-12 hsa-miR-29c-3p THBS2 -0.0526710652467877 0.956320854458284 0.0420384090474553 0.953596062900646 MirTarget -0.431990941588527 4.39914608500664e-20 hsa-miR-301a-3p TGFB2 -0.0522829902990942 0.861546852981366 -0.310431949258206 0.4589149484546 MirTarget;miRNATAP -0.168650734197616 6.85924013793372e-06 hsa-miR-301a-3p BMPR2 -0.0522829902990942 0.861546852981366 -0.138918726013816 0.828173765385504 MirTarget;miRNATAP -0.0896527614408825 1.08679103317856e-08 hsa-miR-301a-3p ACVR1 -0.0522829902990942 0.861546852981366 -0.102018853336211 0.839021129058447 MirTarget;miRNATAP -0.0837357010803688 1.34394785091895e-10 hsa-miR-301a-3p BMP6 -0.0522829902990942 0.861546852981366 -0.0629624972268548 0.790089529546855 MirTarget -0.202490128801353 3.84192366950574e-10 hsa-miR-3065-3p ROCK1 0.22426467087409 0.627407590125411 -0.172548975888922 0.760861741105756 MirTarget -0.0909657729180416 5.53891405765653e-09 hsa-miR-30a-3p BMP8A -0.361790747715233 0.766608518431902 -0.108409346954881 0.732197597338568 MirTarget -0.248477166436933 3.93577730861837e-14 hsa-miR-30a-3p TFDP1 -0.361790747715233 0.766608518431902 0.014580908779898 0.980177571877553 MirTarget;miRNATAP -0.0620536368189177 0.000152569144676337 hsa-miR-30a-5p TFDP1 -0.315304933842571 0.81611555406281 0.014580908779898 0.980177571877553 MirTarget;miRNATAP -0.0814845498791684 1.12345287772838e-06 hsa-miR-30b-5p ACVR1 -0.126278303055191 0.871574517121767 -0.102018853336211 0.839021129058447 MirTarget -0.110759549818898 2.72868569695075e-08 hsa-miR-30c-5p ACVR1 -0.268052278300344 0.753220585849573 -0.102018853336211 0.839021129058447 MirTarget;miRNATAP -0.0613618438841048 0.00580208021571729 hsa-miR-30d-5p ACVR1 0.00512174341017158 0.996390931509314 -0.102018853336211 0.839021129058447 MirTarget;miRNATAP -0.206470425752546 5.29481819061924e-16 hsa-miR-30e-3p BMP8A -0.159454066602024 0.887830180332455 -0.108409346954881 0.732197597338568 MirTarget -0.532592839026743 1.53477893028116e-14 hsa-miR-30e-5p ACVR1 -0.183864098532103 0.86939509445488 -0.102018853336211 0.839021129058447 MirTarget -0.117512420167977 1.27216347278214e-05 hsa-miR-3127-5p ID3 0.0182394265390076 0.945945803678987 0.141925561931471 0.760040401295001 MirTarget -0.189307261244136 2.85579647453505e-12 hsa-miR-32-5p SMAD7 -0.218686304292785 0.59094441655546 -0.050137279965961 0.913873828853954 MirTarget;miRNATAP -0.0830239536253012 1.62085365142455e-06 hsa-miR-320b SMAD9 -0.0203395214664157 0.930562048282019 -0.345301393083487 0.0749607019655454 MirTarget;miRanda -0.183261427871827 0.000478898758737045 hsa-miR-324-3p SMAD7 -0.0533960575545418 0.892365633037602 -0.050137279965961 0.913873828853954 MirTarget -0.0698195590796128 0.000117423449864966 hsa-miR-330-3p ACVR1 -0.00366157141494194 0.98416704678615 -0.102018853336211 0.839021129058447 MirTarget;PITA -0.106644073620098 4.49931005626429e-09 hsa-miR-330-3p ACVR1C -0.00366157141494194 0.98416704678615 -0.242633657325932 0.39426919694045 MirTarget -0.237793048547375 0.00219426575105842 hsa-miR-331-3p ID1 -0.235461895487326 0.594749794653888 -0.128748881044468 0.709093382117699 MirTarget -0.386656508179256 2.65685537692846e-32 hsa-miR-335-3p THBS2 0.248840023734261 0.661533599343062 0.0420384090474553 0.953596062900646 MirTarget;mirMAP -0.104434722339321 0.00143160463399029 hsa-miR-337-3p E2F5 -0.261670200477266 0.586287331335225 -0.0359162560176447 0.910823844965751 MirTarget;PITA -0.228149350398858 4.79737697762728e-19 hsa-miR-338-3p THBS1 -0.00932885158849928 0.989745642009026 -0.0068816911586822 0.993224588441564 MirTarget;PITA;miRanda -0.0848774568195392 0.00454856126045835 hsa-miR-338-3p ACVR1 -0.00932885158849928 0.989745642009026 -0.102018853336211 0.839021129058447 MirTarget;PITA;miRanda;miRNATAP -0.081811566193108 1.22658311296126e-07 hsa-miR-340-5p SMAD5 0.0820090452273905 0.816484190854532 -0.0546789038062157 0.922780020470417 MirTarget -0.168506474975631 1.73300625528468e-14 hsa-miR-340-5p SMAD2 0.0820090452273905 0.816484190854532 -0.0519399062136339 0.930776806456225 MirTarget -0.145840275032375 8.51041709723394e-21 hsa-miR-340-5p BMPR1A 0.0820090452273905 0.816484190854532 -0.119520840785576 0.790693309531106 MirTarget -0.205607556993107 7.51804306692324e-16 hsa-miR-340-5p NOG 0.0820090452273905 0.816484190854532 -0.264314103066992 0.373098587786885 MirTarget -0.168351963860764 0.00820812926837844 hsa-miR-340-5p ZFYVE16 0.0820090452273905 0.816484190854532 -0.0555216392266296 0.91670112258897 MirTarget -0.141874109162048 5.00773877149816e-10 hsa-miR-342-3p ID4 -0.244092268513731 0.741215180994683 -0.203766202154454 0.618845244068564 MirTarget;PITA;miRanda -0.561987569665707 4.7041735736719e-27 24475217;24475217;24475217;24475217;24475217;24475217 miR-342 regulates BRCA1 expression through modulation of ID4 in breast cancer;To investigate at functional level the role of miR-342 in the pathogenesis of breast cancer we focused our attention on its in silico predicted putative target gene ID4 a transcription factor of the helix-loop-helix protein family whose expression is inversely correlated with that of ER;Our results showed an inverse correlation between ID4 and miR-342 as well as between ID4 and BRCA1 expression;Based on these findings we hypothesized that regulation of ID4 mediated by miR-342 could be involved in the pathogenesis of breast cancer by downregulating BRCA1 expression;Overexpression of miR-342 in these cells reduced ID4 and increased BRCA1 expression supporting a possible role of this mechanism in breast cancer;In the ER-positive MCF7 and in the BRCA1-mutant HCC1937 cell lines miR-342 over-expression only reduced ID4 ;;;;; breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer hsa-miR-345-5p ID4 -0.318796500689201 0.40673094545688 -0.203766202154454 0.618845244068564 MirTarget -0.191495513045981 1.97893812018554e-05 hsa-miR-34a-5p SMAD7 -0.00150684423480296 0.998107346259152 -0.050137279965961 0.913873828853954 MirTarget -0.0801072133117801 0.00084518312196073 hsa-miR-34c-5p E2F5 0.0263265725823381 0.923214932412527 -0.0359162560176447 0.910823844965751 MirTarget;PITA;miRanda;miRNATAP -0.132406436564757 2.42305122201497e-06 hsa-miR-3607-3p ID3 -0.410705558355355 0.442005238257379 0.141925561931471 0.760040401295001 MirTarget -0.158567216278868 4.69887121107217e-20 hsa-miR-3607-3p NOG -0.410705558355355 0.442005238257379 -0.264314103066992 0.373098587786885 MirTarget;miRNATAP -0.160771713330531 4.44816935738285e-06 hsa-miR-361-5p SMAD2 0.0775639231585332 0.909963521897996 -0.0519399062136339 0.930776806456225 MirTarget -0.168440579811925 1.40285064429544e-08 hsa-miR-361-5p RHOA 0.0775639231585332 0.909963521897996 0.0333557466121839 0.967744764731311 MirTarget;PITA;miRanda -0.0936136832858473 0.000194241936648477 hsa-miR-361-5p BMPR2 0.0775639231585332 0.909963521897996 -0.138918726013816 0.828173765385504 MirTarget;miRanda;mirMAP;miRNATAP -0.334517180577302 6.53819650110874e-14 hsa-miR-362-5p ACVR2A 0.215268517371166 0.469421708227034 0.0348825940608202 0.925897434335883 MirTarget;PITA -0.0602100516953652 0.0020085436333369 hsa-miR-362-5p RPS6KB1 0.215268517371166 0.469421708227034 0.0179462515277296 0.972140340853137 MirTarget;PITA -0.0507874292426582 0.0150296374327761 hsa-miR-362-5p TGFB2 0.215268517371166 0.469421708227034 -0.310431949258206 0.4589149484546 MirTarget -0.113727114004023 0.0130357663477879 hsa-miR-365a-3p TFDP1 0.0307303320006067 0.959616484776468 0.014580908779898 0.980177571877553 MirTarget -0.119562336866465 2.06776358163436e-08 hsa-miR-369-3p EP300 -0.0734607425694875 0.755351791463265 -0.0381739592699031 0.951249053975231 MirTarget;PITA;miRNATAP -0.0931013138842514 4.21889936505424e-05 hsa-miR-369-3p RPS6KB1 -0.0734607425694875 0.755351791463265 0.0179462515277296 0.972140340853137 MirTarget;PITA -0.109811993589112 1.74070420680125e-06 hsa-miR-374a-3p RHOA -0.0781632437076389 0.926379383884834 0.0333557466121839 0.967744764731311 MirTarget;miRNATAP -0.0748933035031109 4.58606389597479e-05 hsa-miR-374a-3p BMPR2 -0.0781632437076389 0.926379383884834 -0.138918726013816 0.828173765385504 MirTarget;miRNATAP -0.118088688320067 0.000357901047098203 hsa-miR-374a-5p SMAD2 -0.0192159163584709 0.965315201402842 -0.0519399062136339 0.930776806456225 MirTarget -0.0809165767134829 0.000203630233483825 hsa-miR-374a-5p BMPR1B -0.0192159163584709 0.965315201402842 -0.134747300369366 0.797657104320608 MirTarget -1.34531949769775 2.36721949756409e-16 hsa-miR-374a-5p ACVR2B -0.0192159163584709 0.965315201402842 -0.152487710062183 0.689782894367425 MirTarget -0.169809922205124 2.0190940823835e-06 hsa-miR-374b-5p BMPR1B -0.0341588728964348 0.947017013085837 -0.134747300369366 0.797657104320608 MirTarget -1.21428024206699 6.08013000870106e-14 hsa-miR-374b-5p ACVR2B -0.0341588728964348 0.947017013085837 -0.152487710062183 0.689782894367425 MirTarget -0.119604328959342 0.000690837262808481 hsa-miR-381-3p RPS6KB1 -0.0215856799485721 0.961260144775191 0.0179462515277296 0.972140340853137 MirTarget -0.11550176003524 1.23132177175341e-07 hsa-miR-3913-5p SMAD2 -0.0522230839821796 0.748170987254748 -0.0519399062136339 0.930776806456225 MirTarget;miRNATAP -0.0770824324478119 1.2863805986301e-05 hsa-miR-3913-5p SMAD9 -0.0522230839821796 0.748170987254748 -0.345301393083487 0.0749607019655454 MirTarget -0.271542382003726 4.71665561492278e-05 hsa-miR-423-5p BMP8A -0.0275038364546472 0.956931958131863 -0.108409346954881 0.732197597338568 MirTarget -0.205933948944955 0.000518526442624442 hsa-miR-423-5p BMP8B -0.0275038364546472 0.956931958131863 -0.353923600213929 0.116867182670808 MirTarget -0.153976492043689 0.0210570163676643 hsa-miR-425-5p FST -0.179935054542016 0.805737521016457 -0.0481855465289094 0.873185390251465 MirTarget -0.237691780818936 1.47116649494804e-06 hsa-miR-429 PPP2R1B -0.142589289838583 0.802317907773415 -0.00522798350256881 0.991408260059311 MirTarget;miRanda;miRNATAP -0.148415458438853 1.78268855237664e-18 hsa-miR-429 RPS6KB1 -0.142589289838583 0.802317907773415 0.0179462515277296 0.972140340853137 MirTarget;PITA;miRanda;miRNATAP -0.0559369677358783 0.000449631707887529 hsa-miR-429 NOG -0.142589289838583 0.802317907773415 -0.264314103066992 0.373098587786885 MirTarget;PITA;miRanda;miRNATAP -0.221990432368383 7.7539335905232e-09 hsa-miR-454-3p TGFB2 -0.0807547300787816 0.779337172929459 -0.310431949258206 0.4589149484546 MirTarget;miRNATAP -0.21652241903686 1.80168797038491e-06 hsa-miR-454-3p ZFYVE9 -0.0807547300787816 0.779337172929459 -0.12199434575654 0.788138337240637 MirTarget;miRNATAP -0.0955205135840922 0.000127754504890165 hsa-miR-454-3p BMPR2 -0.0807547300787816 0.779337172929459 -0.138918726013816 0.828173765385504 MirTarget;miRNATAP -0.0948773535763793 6.1465653632283e-07 hsa-miR-454-3p ACVR1 -0.0807547300787816 0.779337172929459 -0.102018853336211 0.839021129058447 MirTarget;miRNATAP -0.0955458819059395 1.48801259661674e-09 hsa-miR-454-3p BMP6 -0.0807547300787816 0.779337172929459 -0.0629624972268548 0.790089529546855 MirTarget -0.283576224076596 3.53482708336303e-13 hsa-miR-455-3p ZFYVE16 -0.332546859679539 0.617979023781481 -0.0555216392266296 0.91670112258897 MirTarget -0.0765112791677388 8.24262428718719e-09 hsa-miR-455-5p RPS6KB1 -0.196032525410701 0.627038966906064 0.0179462515277296 0.972140340853137 MirTarget;PITA;miRanda -0.195839125781244 5.6227516619354e-21 hsa-miR-455-5p BMP8A -0.196032525410701 0.627038966906064 -0.108409346954881 0.732197597338568 MirTarget;miRanda -0.0820196190156059 0.0320280479932661 hsa-miR-495-3p E2F5 -0.159204559213757 0.555240058524588 -0.0359162560176447 0.910823844965751 MirTarget -0.238991250342934 6.79487454514355e-16 hsa-miR-495-3p TFDP1 -0.159204559213757 0.555240058524588 0.014580908779898 0.980177571877553 MirTarget -0.0884041699483346 7.01578866457753e-07 hsa-miR-500a-5p RPS6KB1 0.0097790305601746 0.958449089566593 0.0179462515277296 0.972140340853137 MirTarget -0.0746327823656674 0.000602877824253953 hsa-miR-500b-5p ACVR2A 0.00357100623630302 0.984818138339135 0.0348825940608202 0.925897434335883 MirTarget -0.0580067905300957 0.00438500727943447 hsa-miR-500b-5p RPS6KB1 0.00357100623630302 0.984818138339135 0.0179462515277296 0.972140340853137 MirTarget -0.0745002130949921 0.000621100762559057 hsa-miR-505-3p FST -0.245807419731662 0.59093461248251 -0.0481855465289094 0.873185390251465 MirTarget -0.201062759837977 4.31672871793938e-05 hsa-miR-511-5p SKP1 -0.310767354974383 0.310390422401541 0.11984894684252 0.870895899955478 MirTarget -0.0784856241501618 1.35270082389214e-12 hsa-miR-511-5p TGFB3 -0.310767354974383 0.310390422401541 0.111124424488611 0.835380319895798 MirTarget -0.161630488068991 4.28099557548626e-13 hsa-miR-550a-5p THBS3 -0.272797512255039 0.162336481604492 -0.0219496012565683 0.964415986497255 MirTarget -0.0588160474075568 0.00199393421936486 hsa-miR-589-3p GDF6 -0.0679748049633819 0.703146664597157 0.127943908145237 0.526417832939525 MirTarget -0.0890395394970252 0.0236824038024728 hsa-miR-589-5p BMPR1A -0.0214815940746442 0.967157138449855 -0.119520840785576 0.790693309531106 MirTarget -0.124623957239379 0.000198491088497215 hsa-miR-590-3p SMAD4 -0.133358268237272 0.535686159072243 -0.0337260829637342 0.952673159973339 MirTarget;PITA;miRanda;miRNATAP -0.088164834648131 2.90407325908758e-07 hsa-miR-590-3p ACVR2A -0.133358268237272 0.535686159072243 0.0348825940608202 0.925897434335883 MirTarget;PITA;miRanda;miRNATAP -0.128362682046608 2.20895457265325e-09 hsa-miR-590-3p SMAD5 -0.133358268237272 0.535686159072243 -0.0546789038062157 0.922780020470417 MirTarget;PITA;miRanda;miRNATAP -0.115113637124871 3.79175944135625e-09 hsa-miR-590-3p BMPR2 -0.133358268237272 0.535686159072243 -0.138918726013816 0.828173765385504 MirTarget;miRanda;mirMAP;miRNATAP -0.132760837851511 3.2984433329505e-10 hsa-miR-590-3p DCN -0.133358268237272 0.535686159072243 0.00731810243205899 0.993040111761826 MirTarget;PITA;miRanda;mirMAP -0.52916176505448 1.07716522597725e-25 hsa-miR-590-5p SMAD7 -0.131787544750195 0.684613701486826 -0.050137279965961 0.913873828853954 MirTarget;PITA;miRanda;miRNATAP -0.0859641957844214 3.76661505306892e-08 hsa-miR-590-5p BMPR2 -0.131787544750195 0.684613701486826 -0.138918726013816 0.828173765385504 MirTarget;PITA;miRNATAP -0.0949800465364401 2.86572497529027e-06 hsa-miR-625-5p LEFTY2 -0.121097781227008 0.486746151168725 0.166294618858231 0.611364853254296 MirTarget -0.588222186492936 6.68599338061733e-15 hsa-miR-629-3p SMAD9 -0.203962319893151 0.416043359122368 -0.345301393083487 0.0749607019655454 MirTarget -0.129618035464659 0.00148949379270889 hsa-miR-629-3p TGFB3 -0.203962319893151 0.416043359122368 0.111124424488611 0.835380319895798 MirTarget -0.184738491466436 9.18913270065683e-13 hsa-miR-629-3p ID4 -0.203962319893151 0.416043359122368 -0.203766202154454 0.618845244068564 MirTarget -0.375561354103374 2.07412660127111e-16 hsa-miR-671-5p ACVR2A 0.0238736022615038 0.908889383230195 0.0348825940608202 0.925897434335883 MirTarget;PITA;miRNATAP -0.178633008800824 2.95102208280371e-19 hsa-miR-671-5p SMAD3 0.0238736022615038 0.908889383230195 -0.00805727245311783 0.987902560465751 MirTarget -0.132445297015047 2.33568059728177e-10 hsa-miR-671-5p THBS1 0.0238736022615038 0.908889383230195 -0.0068816911586822 0.993224588441564 MirTarget -0.149992236442967 2.76078556306308e-06 hsa-miR-7-1-3p THBS2 -0.0332815306858167 0.935725386085843 0.0420384090474553 0.953596062900646 MirTarget;mirMAP -0.1868408017881 6.41716930046462e-06 hsa-miR-7-1-3p LTBP1 -0.0332815306858167 0.935725386085843 -0.0847739199441895 0.876948200966833 MirTarget -0.17161457210631 1.26152528774934e-07 hsa-miR-769-5p FST -0.10362464632991 0.793365222563107 -0.0481855465289094 0.873185390251465 MirTarget;miRNATAP -0.577653562671636 2.58108369401135e-16 hsa-miR-889-3p SMAD2 -0.0891386913656023 0.781493366587911 -0.0519399062136339 0.930776806456225 MirTarget -0.0764186857472352 4.12381359190026e-09 hsa-miR-889-3p SMAD5 -0.0891386913656023 0.781493366587911 -0.0546789038062157 0.922780020470417 MirTarget -0.0583895358291621 0.0014149207733694 hsa-miR-889-3p BMPR1B -0.0891386913656023 0.781493366587911 -0.134747300369366 0.797657104320608 MirTarget -0.507675391479965 3.5174865160677e-07 hsa-miR-93-5p RBL2 0.0554251653547535 0.959380932710413 -0.0695922475238753 0.906902559203765 MirTarget;miRNATAP -0.257781038097889 8.64400419240358e-25 hsa-miR-93-5p SMAD5 0.0554251653547535 0.959380932710413 -0.0546789038062157 0.922780020470417 MirTarget;miRNATAP -0.221519222334676 5.38905029663131e-24 hsa-miR-93-5p ZFYVE9 0.0554251653547535 0.959380932710413 -0.12199434575654 0.788138337240637 MirTarget;miRNATAP -0.159671948388364 4.86451485844907e-07 hsa-miR-93-5p THBS2 0.0554251653547535 0.959380932710413 0.0420384090474553 0.953596062900646 MirTarget -0.273544363928753 3.16076912551438e-08 hsa-miR-942-5p CREBBP -0.114486919487105 0.623023233194388 -0.121528460671809 0.849036225288355 MirTarget -0.0723534657547835 1.26909739768754e-06 hsa-miR-942-5p ZFYVE16 -0.114486919487105 0.623023233194388 -0.0555216392266296 0.91670112258897 MirTarget -0.153911307617604 1.72509867587362e-17 hsa-miR-98-5p GDF6 0.0782917740368987 0.880173437070493 0.127943908145237 0.526417832939525 MirTarget -0.289588587887271 3.72588812074349e-05 hsa-miR-98-5p DCN 0.0782917740368987 0.880173437070493 0.00731810243205899 0.993040111761826 MirTarget -0.691424742968624 1.12225257396507e-20 hsa-miR-98-5p CHRD 0.0782917740368987 0.880173437070493 0.0538554939791851 0.885642347857914 MirTarget -0.733946495195942 8.35827564110485e-19 hsa-miR-98-5p ACVR1C 0.0782917740368987 0.880173437070493 -0.242633657325932 0.39426919694045 MirTarget -0.793231535265132 2.56641262477936e-13 hsa-miR-590-5p PITX2 -0.131787544750195 0.684613701486826 -0.063293467496382 0.757965460757416 PITA;miRanda;miRNATAP -0.18617831800215 0.000230247172854942 hsa-miR-330-3p GDF6 -0.00366157141494194 0.98416704678615 0.127943908145237 0.526417832939525 PITA;miRNATAP -0.168151107267975 0.000719056491443551 hsa-miR-429 GDF6 -0.142589289838583 0.802317907773415 0.127943908145237 0.526417832939525 PITA;miRanda;miRNATAP -0.195401437731195 3.19568062685289e-09 hsa-miR-532-3p GDF6 -0.247223762437475 0.58134232021997 0.127943908145237 0.526417832939525 PITA;miRNATAP -0.165327279580597 5.57617374827518e-05 hsa-miR-542-3p SMAD2 0.11706603007597 0.867078497673182 -0.0519399062136339 0.930776806456225 PITA -0.104251622984305 3.31535587210055e-12 hsa-miR-361-5p CREBBP 0.0775639231585332 0.909963521897996 -0.121528460671809 0.849036225288355 PITA;miRanda;miRNATAP -0.169327426710038 1.27069129226647e-06 hsa-miR-590-3p CREBBP -0.133358268237272 0.535686159072243 -0.121528460671809 0.849036225288355 PITA;miRanda;mirMAP;miRNATAP -0.100564166407458 8.68617817381304e-10 hsa-miR-769-5p ZFYVE16 -0.10362464632991 0.793365222563107 -0.0555216392266296 0.91670112258897 PITA;miRNATAP -0.0896123869793811 0.00107759851417366 hsa-miR-142-5p ACVR2B -0.35195621065247 0.488286772825655 -0.152487710062183 0.689782894367425 PITA -0.0851018110996512 1.97101726814534e-06 hsa-miR-199a-5p ACVR2B -0.0114843373708311 0.9900489817393 -0.152487710062183 0.689782894367425 PITA;miRNATAP -0.0851662703990942 0.000376786092174661 hsa-miR-199b-5p ACVR2B -0.0420618710265854 0.953083764782006 -0.152487710062183 0.689782894367425 PITA -0.0801500655275752 0.000212233444952713 hsa-miR-409-3p ACVR2B -0.189095517827509 0.636954104687463 -0.152487710062183 0.689782894367425 PITA -0.0830994449719605 0.000687205840417602 hsa-miR-450b-5p ACVR2B 0.140781738083346 0.700777724167455 -0.152487710062183 0.689782894367425 PITA -0.0772866551710391 0.00139699007030469 hsa-miR-455-5p ACVR2B -0.196032525410701 0.627038966906064 -0.152487710062183 0.689782894367425 PITA -0.125395914976428 3.22447748901509e-09 hsa-miR-671-5p ACVR2B 0.0238736022615038 0.908889383230195 -0.152487710062183 0.689782894367425 PITA -0.0700205940661951 0.0012998948794453 hsa-miR-590-3p BMP2 -0.133358268237272 0.535686159072243 -0.222038347742825 0.284722031687683 PITA;miRanda;mirMAP -0.178033380986492 0.000666105040333196 hsa-miR-142-3p BMP4 -0.419981832465888 0.660228548488659 0.259009232032601 0.435488950825572 PITA;miRanda -0.225090005062372 1.21121726101325e-10 hsa-miR-330-3p BMPR2 -0.00366157141494194 0.98416704678615 -0.138918726013816 0.828173765385504 PITA;miRNATAP -0.0709176644030471 0.00124786222382919 hsa-miR-455-5p BMPR2 -0.196032525410701 0.627038966906064 -0.138918726013816 0.828173765385504 PITA -0.150702454713517 6.6886302737598e-15 hsa-miR-532-5p BMPR2 0.0193679288578856 0.981424049788362 -0.138918726013816 0.828173765385504 PITA -0.19453245376842 3.69016564906427e-12 hsa-miR-361-3p EP300 -0.0127254134873924 0.984476698818773 -0.0381739592699031 0.951249053975231 PITA -0.139187579360879 0.000249736724501524 hsa-miR-142-5p ACVR2A -0.35195621065247 0.488286772825655 0.0348825940608202 0.925897434335883 PITA;mirMAP -0.0527960737432987 0.00163965132876147 hsa-miR-331-5p ACVR2A -0.143249163277681 0.38317955643253 0.0348825940608202 0.925897434335883 PITA -0.179622432713345 2.56782330912698e-12 hsa-miR-429 ACVR2A -0.142589289838583 0.802317907773415 0.0348825940608202 0.925897434335883 PITA;miRanda;miRNATAP -0.146889740348126 4.18297883812051e-24 hsa-miR-320b BMP6 -0.0203395214664157 0.930562048282019 -0.0629624972268548 0.790089529546855 PITA;miRanda -0.0894125440193577 0.0402482101077748 hsa-miR-769-5p ID3 -0.10362464632991 0.793365222563107 0.141925561931471 0.760040401295001 PITA -0.267539804472467 1.22678247541039e-12 hsa-miR-140-3p MAPK1 -0.0813609197213889 0.923953795876038 -0.0485161469138511 0.940405206700101 PITA;miRNATAP -0.0738800427825067 0.000142927367071222 hsa-miR-361-5p MAPK1 0.0775639231585332 0.909963521897996 -0.0485161469138511 0.940405206700101 PITA;miRanda;mirMAP -0.263780179525808 1.39108568009728e-13 hsa-miR-107 RPS6KB1 -0.00374429919903285 0.994322461958742 0.0179462515277296 0.972140340853137 PITA;miRanda -0.0780058789818232 0.0236861425938598 hsa-miR-217 RPS6KB1 -0.0872981480242543 0.809509315744678 0.0179462515277296 0.972140340853137 PITA;miRanda -0.097227938497799 9.55545408190185e-08 hsa-miR-320a TGFBR1 0.0425274543382255 0.958191670788918 -0.141408193828913 0.803114596838615 PITA;miRanda;miRNATAP -0.136624380256683 0.000172858923508737 hsa-miR-320b TGFBR1 -0.0203395214664157 0.930562048282019 -0.141408193828913 0.803114596838615 PITA;miRanda;miRNATAP -0.0941529907628416 0.000279339630667605 hsa-miR-769-5p TGFBR1 -0.10362464632991 0.793365222563107 -0.141408193828913 0.803114596838615 PITA;miRNATAP -0.0803067378931805 0.0236018812461104 hsa-miR-369-3p ROCK2 -0.0734607425694875 0.755351791463265 -0.273205140377062 0.589812182930179 PITA -0.0797264564664897 0.0390769081549399 hsa-miR-429 ROCK2 -0.142589289838583 0.802317907773415 -0.273205140377062 0.589812182930179 PITA;miRanda;miRNATAP -0.205818358236693 4.93110698663187e-15 hsa-miR-146b-5p SMAD4 0.00834882458611474 0.991577009242932 -0.0337260829637342 0.952673159973339 PITA;miRanda;miRNATAP -0.13881112685924 1.84558785229961e-14 hsa-miR-429 SMAD4 -0.142589289838583 0.802317907773415 -0.0337260829637342 0.952673159973339 PITA;miRanda;miRNATAP -0.0739655521525238 3.65996392590515e-10 hsa-miR-142-5p SMAD3 -0.35195621065247 0.488286772825655 -0.00805727245311783 0.987902560465751 PITA -0.0900603692355694 1.94054167645626e-07 24558198 On TGF-β1 stimulation stable overexpression of miR-142-3p attenuated phosphorylation of SMAD3 an indispensable downstream effector in canonical TGF-β/Smad signaling via repression of TGFβR1 in A549 cells lung cancer hsa-miR-671-5p SMAD7 0.0238736022615038 0.908889383230195 -0.050137279965961 0.913873828853954 PITA -0.0780413685881868 3.98374177117938e-07 hsa-miR-320b FST -0.0203395214664157 0.930562048282019 -0.0481855465289094 0.873185390251465 PITA;miRanda -0.17874343125668 0.00065840102461666 hsa-miR-326 THBS3 -0.134657725127161 0.690379143543161 -0.0219496012565683 0.964415986497255 PITA -0.120857065691596 6.87702237562674e-16 hsa-miR-429 SMURF2 -0.142589289838583 0.802317907773415 -0.0458805490678218 0.915316384499453 PITA;miRanda;miRNATAP -0.052690605667607 0.000732448449158288 hsa-miR-671-5p CDKN2B 0.0238736022615038 0.908889383230195 0.0676204813199117 0.875382601126992 PITA -0.154028875207593 8.10893805948914e-06 hsa-miR-140-3p SP1 -0.0813609197213889 0.923953795876038 -0.0580656653051959 0.929748914906324 PITA -0.133134295207693 3.89559470917654e-16 hsa-miR-361-5p SP1 0.0775639231585332 0.909963521897996 -0.0580656653051959 0.929748914906324 PITA;miRanda;mirMAP -0.255788486421106 3.35834132000944e-17 hsa-miR-671-5p SP1 0.0238736022615038 0.908889383230195 -0.0580656653051959 0.929748914906324 PITA -0.110400251438575 2.24476925034465e-16 hsa-miR-429 ACVR1C -0.142589289838583 0.802317907773415 -0.242633657325932 0.39426919694045 PITA;miRanda;miRNATAP -0.697810047692677 7.01989078734797e-46 hsa-miR-590-5p ACVR1C -0.131787544750195 0.684613701486826 -0.242633657325932 0.39426919694045 PITA;miRanda -0.445957185891423 4.05699479656914e-10 hsa-miR-96-5p ACVR1 -0.153312892459014 0.726115467443483 -0.102018853336211 0.839021129058447 TargetScan;miRNATAP -0.100604313502428 1.25599818730201e-15 hsa-miR-200b-3p ACVR1C -0.109983892590611 0.891357972128093 -0.242633657325932 0.39426919694045 TargetScan -0.692003711219126 2.03439748086501e-35 hsa-miR-96-5p ACVR2A -0.153312892459014 0.726115467443483 0.0348825940608202 0.925897434335883 TargetScan;miRNATAP -0.154150910111768 2.30970117244934e-24 hsa-miR-141-3p ACVR2A -0.179420502124191 0.83354105481228 0.0348825940608202 0.925897434335883 TargetScan;miRNATAP -0.161379309311092 1.25725298325859e-27 hsa-miR-200b-3p ACVR2A -0.109983892590611 0.891357972128093 0.0348825940608202 0.925897434335883 TargetScan -0.143541862814667 1.76104677420962e-18 hsa-miR-96-5p EP300 -0.153312892459014 0.726115467443483 -0.0381739592699031 0.951249053975231 TargetScan;miRNATAP -0.0595632604448432 0.000290513265618238 hsa-miR-200b-3p GDF6 -0.109983892590611 0.891357972128093 0.127943908145237 0.526417832939525 TargetScan -0.235189970868671 1.83473115362667e-10 hsa-miR-141-3p GDF6 -0.179420502124191 0.83354105481228 0.127943908145237 0.526417832939525 TargetScan -0.245691412390661 3.02382137529226e-13 hsa-miR-141-3p PITX2 -0.179420502124191 0.83354105481228 -0.063293467496382 0.757965460757416 TargetScan;miRNATAP -0.223717264715575 1.74572061948343e-09 hsa-miR-362-5p PPP2CA 0.215268517371166 0.469421708227034 0.0284217367477391 0.96534362029265 TargetScan -0.0585906903629201 2.80979771025798e-06 hsa-miR-17-5p PPP2CA -0.0085894792332244 0.990927211793889 0.0284217367477391 0.96534362029265 TargetScan -0.0598139731984396 2.30783397825974e-06 hsa-miR-200b-3p ROCK2 -0.109983892590611 0.891357972128093 -0.273205140377062 0.589812182930179 TargetScan -0.238045362418837 5.70621727270586e-16 hsa-miR-17-5p SMAD1 -0.0085894792332244 0.990927211793889 -0.0334597572408715 0.944853393720768 TargetScan -0.0654944974877628 4.03329598417111e-05 hsa-miR-17-5p SMAD6 -0.0085894792332244 0.990927211793889 -0.00809188507489367 0.969183109415995 TargetScan -0.098667850531905 0.000144173343098686 hsa-miR-200b-3p SMAD9 -0.109983892590611 0.891357972128093 -0.345301393083487 0.0749607019655454 TargetScan -0.433450642046697 1.02300809234532e-27 hsa-miR-200b-3p SMURF2 -0.109983892590611 0.891357972128093 -0.0458805490678218 0.915316384499453 TargetScan -0.0792927053124052 5.34661956237024e-06 hsa-let-7a-5p TGFBR1 -0.0656092877172174 0.961124733677684 -0.141408193828913 0.803114596838615 TargetScan;miRNATAP -0.135014125369019 0.00134477571196012 hsa-miR-96-5p TGFBR1 -0.153312892459014 0.726115467443483 -0.141408193828913 0.803114596838615 TargetScan;miRNATAP -0.0907667180613538 1.39248233498119e-06 hsa-miR-501-3p TGFBR2 0.0142885468386682 0.976243386478648 -0.0248163256603231 0.968537582777159 TargetScan -0.0782108991377729 0.0437042871872616 hsa-miR-96-5p THBS2 -0.153312892459014 0.726115467443483 0.0420384090474553 0.953596062900646 TargetScan;miRNATAP -0.0685516516794185 0.0285592790739325 hsa-miR-17-5p ZFYVE16 -0.0085894792332244 0.990927211793889 -0.0555216392266296 0.91670112258897 TargetScan -0.196958418309225 4.90709383973576e-28 hsa-miR-28-5p SP1 -0.212713060051394 0.714914931441106 -0.0580656653051959 0.929748914906324 miRanda -0.0793292332042037 0.00165592239360197 hsa-miR-107 TGFBR2 -0.00374429919903285 0.994322461958742 -0.0248163256603231 0.968537582777159 miRanda;miRNATAP -0.530917906321599 1.66581882091816e-22 hsa-miR-107 ACVR1 -0.00374429919903285 0.994322461958742 -0.102018853336211 0.839021129058447 miRanda -0.341475890592561 4.28612624303003e-42 hsa-miR-107 TGFB2 -0.00374429919903285 0.994322461958742 -0.310431949258206 0.4589149484546 miRanda -0.401875565283925 8.76701815465238e-08 hsa-miR-107 ROCK1 -0.00374429919903285 0.994322461958742 -0.172548975888922 0.760861741105756 miRanda -0.214652817656713 7.4445514442289e-10 hsa-miR-107 RBL2 -0.00374429919903285 0.994322461958742 -0.0695922475238753 0.906902559203765 miRanda -0.214816939727489 9.7538516274009e-11 hsa-miR-107 SMURF2 -0.00374429919903285 0.994322461958742 -0.0458805490678218 0.915316384499453 miRanda -0.092649234246274 0.00599908554427497 hsa-miR-107 ZFYVE16 -0.00374429919903285 0.994322461958742 -0.0555216392266296 0.91670112258897 miRanda -0.223514903985007 6.44816088972544e-14 hsa-miR-199a-5p E2F5 -0.0114843373708311 0.9900489817393 -0.0359162560176447 0.910823844965751 miRanda -0.303224745258506 3.21231496741469e-18 hsa-miR-199a-5p PPP2R1A -0.0114843373708311 0.9900489817393 0.0981760857696141 0.894638367692319 miRanda -0.0559524497282798 0.00105266363104996 hsa-miR-199a-5p RPS6KB1 -0.0114843373708311 0.9900489817393 0.0179462515277296 0.972140340853137 miRanda -0.084494661154887 0.000415519226285963 hsa-miR-199a-5p RBL1 -0.0114843373708311 0.9900489817393 -0.00762815276935669 0.980577451432883 miRanda -0.16646935754867 1.35556669022578e-05 hsa-miR-139-5p RBX1 0.00543145985495741 0.991591290852214 0.11597267591947 0.817045814738048 miRanda -0.138659130309957 7.99349725093936e-22 hsa-miR-139-5p TGFB1 0.00543145985495741 0.991591290852214 0.093038025024498 0.85261027429208 miRanda -0.0815065335623286 1.97809405646523e-05 hsa-miR-139-5p THBS2 0.00543145985495741 0.991591290852214 0.0420384090474553 0.953596062900646 miRanda -0.18351393710485 1.38608699702018e-08 hsa-miR-199b-5p E2F5 -0.0420618710265854 0.953083764782006 -0.0359162560176447 0.910823844965751 miRanda -0.336927501630045 2.45223402264681e-27 hsa-miR-199b-5p PPP2R1A -0.0420618710265854 0.953083764782006 0.0981760857696141 0.894638367692319 miRanda -0.0924456255215766 1.59185765000013e-09 hsa-miR-199b-5p RPS6KB1 -0.0420618710265854 0.953083764782006 0.0179462515277296 0.972140340853137 miRanda -0.074991727914173 0.000527780124514525 hsa-miR-199b-5p RBL1 -0.0420618710265854 0.953083764782006 -0.00762815276935669 0.980577451432883 miRanda -0.19173327799932 2.62627664412876e-08 hsa-miR-140-5p BMP8A -0.310979285894735 0.512489148244786 -0.108409346954881 0.732197597338568 miRanda -0.17092515217601 0.000682416339622627 hsa-miR-142-3p TGFBR2 -0.419981832465888 0.660228548488659 -0.0248163256603231 0.968537582777159 miRanda -0.0576030190044022 0.0227661490275356 hsa-miR-142-3p SKP1 -0.419981832465888 0.660228548488659 0.11984894684252 0.870895899955478 miRanda -0.0750202865852105 2.92710918256477e-11 hsa-miR-142-3p PITX2 -0.419981832465888 0.660228548488659 -0.063293467496382 0.757965460757416 miRanda -0.123411579888614 0.000537635375930706 hsa-miR-142-3p ID4 -0.419981832465888 0.660228548488659 -0.203766202154454 0.618845244068564 miRanda -0.1596411705813 8.83747406478823e-05 hsa-miR-142-3p THBS4 -0.419981832465888 0.660228548488659 0.265649364147748 0.589449475741945 miRanda -0.240044523261729 1.6805188940302e-07 hsa-miR-142-3p ZFYVE16 -0.419981832465888 0.660228548488659 -0.0555216392266296 0.91670112258897 miRanda -0.0507016846333664 0.000207869880280991 hsa-miR-125a-5p RPS6KB2 0.00741438556537055 0.993308396064258 0.246517832398615 0.597989475555673 miRanda -0.276064765205245 1.34823621720886e-17 hsa-miR-125a-5p SMAD6 0.00741438556537055 0.993308396064258 -0.00809188507489367 0.969183109415995 miRanda -0.147230804491131 5.90680183588677e-05 hsa-miR-125a-5p IFNG 0.00741438556537055 0.993308396064258 -0.262545226242447 0.489033107088318 miRanda -0.633234290202444 1.34334735769906e-12 hsa-miR-125a-3p ACVR1 -0.0516703286850553 0.806463674361179 -0.102018853336211 0.839021129058447 miRanda -0.0557360566278237 0.00715057726475861 hsa-miR-125a-3p BMP4 -0.0516703286850553 0.806463674361179 0.259009232032601 0.435488950825572 miRanda -0.163298863788863 0.00752732533450238 hsa-miR-125a-3p ZFYVE16 -0.0516703286850553 0.806463674361179 -0.0555216392266296 0.91670112258897 miRanda -0.0739598312256686 0.00178489728065712 hsa-miR-193a-3p GDF6 -0.0143163678163178 0.969244019090322 0.127943908145237 0.526417832939525 miRanda -0.290674999402467 9.37034296350216e-08 hsa-miR-193a-3p NOG -0.0143163678163178 0.969244019090322 -0.264314103066992 0.373098587786885 miRanda -0.275126823769095 1.51379024971198e-05 hsa-miR-320a ZFYVE16 0.0425274543382255 0.958191670788918 -0.0555216392266296 0.91670112258897 miRanda -0.0822896898473782 0.00351837422020632 hsa-miR-320a ACVR1 0.0425274543382255 0.958191670788918 -0.102018853336211 0.839021129058447 miRanda -0.0636435478557152 0.00989760044591926 hsa-miR-320a ROCK1 0.0425274543382255 0.958191670788918 -0.172548975888922 0.760861741105756 miRanda -0.0684779206018823 0.0370901073300847 hsa-miR-34c-5p EP300 0.0263265725823381 0.923214932412527 -0.0381739592699031 0.951249053975231 miRanda -0.0562380402915782 0.00276161473750972 hsa-miR-34c-5p BMP8B 0.0263265725823381 0.923214932412527 -0.353923600213929 0.116867182670808 miRanda -0.143603564254755 0.000168923059126371 hsa-miR-34c-5p MAPK1 0.0263265725823381 0.923214932412527 -0.0485161469138511 0.940405206700101 miRanda;mirMAP -0.0585663297511988 2.69064657403864e-05 hsa-miR-361-5p ZFYVE16 0.0775639231585332 0.909963521897996 -0.0555216392266296 0.91670112258897 miRanda -0.326076241829422 1.66812492825897e-14 hsa-miR-361-5p RPS6KB1 0.0775639231585332 0.909963521897996 0.0179462515277296 0.972140340853137 miRanda -0.315724779040643 8.68560752083352e-11 hsa-miR-361-5p TGFBR1 0.0775639231585332 0.909963521897996 -0.141408193828913 0.803114596838615 miRanda;mirMAP;miRNATAP -0.343826208469508 4.82441885336511e-10 hsa-miR-375 NOG 0.324254910768071 0.784908661939924 -0.264314103066992 0.373098587786885 miRanda -0.0625339961831094 0.0205237965942572 hsa-miR-330-5p SMAD3 -0.0582594636115701 0.896794748650637 -0.00805727245311783 0.987902560465751 miRanda -0.106180722787539 5.07248451793749e-05 hsa-miR-330-5p SMAD6 -0.0582594636115701 0.896794748650637 -0.00809188507489367 0.969183109415995 miRanda -0.168856954307778 3.63129698842582e-07 hsa-miR-330-5p TGFB2 -0.0582594636115701 0.896794748650637 -0.310431949258206 0.4589149484546 miRanda -0.231096330328837 9.82035598821339e-05 hsa-miR-330-5p ID4 -0.0582594636115701 0.896794748650637 -0.203766202154454 0.618845244068564 miRanda -0.339362600232543 1.52442544121729e-06 hsa-miR-342-3p PITX2 -0.244092268513731 0.741215180994683 -0.063293467496382 0.757965460757416 miRanda -0.307217323830506 4.38245157775331e-11 hsa-miR-342-3p GDF5 -0.244092268513731 0.741215180994683 -0.383041603199474 0.169545261648275 miRanda -0.50811169463946 4.33189323314316e-16 hsa-miR-342-3p DCN -0.244092268513731 0.741215180994683 0.00731810243205899 0.993040111761826 miRanda -0.287211968356635 3.67914088909684e-10 hsa-miR-326 SMAD6 -0.134657725127161 0.690379143543161 -0.00809188507489367 0.969183109415995 miRanda -0.0590141293470312 0.00226744667561353 hsa-miR-326 BMP8A -0.134657725127161 0.690379143543161 -0.108409346954881 0.732197597338568 miRanda -0.0633535277722566 0.0244831580806534 hsa-miR-324-5p GDF6 -0.166270923976542 0.685489008903759 0.127943908145237 0.526417832939525 miRanda -0.184054486893969 1.15350981651547e-05 hsa-miR-324-5p PITX2 -0.166270923976542 0.685489008903759 -0.063293467496382 0.757965460757416 miRanda -0.170316421259242 0.000223031249664272 hsa-miR-338-3p TGFBR1 -0.00932885158849928 0.989745642009026 -0.141408193828913 0.803114596838615 miRanda -0.16505256729074 3.45773945956773e-13 hsa-miR-338-3p LEFTY2 -0.00932885158849928 0.989745642009026 0.166294618858231 0.611364853254296 miRanda -0.20755507497088 0.00325901540293462 hsa-miR-338-3p SMURF2 -0.00932885158849928 0.989745642009026 -0.0458805490678218 0.915316384499453 miRanda -0.0811899601649107 4.06777739425637e-05 hsa-miR-338-3p BMP7 -0.00932885158849928 0.989745642009026 0.205155019863216 0.498498426920493 miRanda -0.235089742330144 6.0197758781171e-05 hsa-miR-339-5p TGFBR1 -0.119339443611091 0.808593831380581 -0.141408193828913 0.803114596838615 miRanda -0.0781272841165453 0.00571648457432763 hsa-miR-339-5p GDF6 -0.119339443611091 0.808593831380581 0.127943908145237 0.526417832939525 miRanda -0.192415748893717 0.000207169195414695 hsa-miR-339-5p LEFTY2 -0.119339443611091 0.808593831380581 0.166294618858231 0.611364853254296 miRanda -0.377171635832493 1.29129734779697e-05 hsa-miR-339-5p ID4 -0.119339443611091 0.808593831380581 -0.203766202154454 0.618845244068564 miRanda -0.181737763314177 0.0053118301994014 hsa-miR-429 LTBP1 -0.142589289838583 0.802317907773415 -0.0847739199441895 0.876948200966833 miRanda;miRNATAP -0.0969074363800378 3.70514097929274e-05 hsa-miR-429 SMAD6 -0.142589289838583 0.802317907773415 -0.00809188507489367 0.969183109415995 miRanda -0.1319320154552 1.11141762738611e-11 hsa-miR-429 ROCK1 -0.142589289838583 0.802317907773415 -0.172548975888922 0.760861741105756 miRanda -0.107368538530982 2.74283719948915e-11 hsa-miR-429 TGFBR1 -0.142589289838583 0.802317907773415 -0.141408193828913 0.803114596838615 miRanda;miRNATAP -0.101210444459427 1.79034747294782e-08 hsa-miR-429 SMAD5 -0.142589289838583 0.802317907773415 -0.0546789038062157 0.922780020470417 miRanda;miRNATAP -0.0880066066306357 5.64891975451991e-11 hsa-miR-429 SMAD9 -0.142589289838583 0.802317907773415 -0.345301393083487 0.0749607019655454 miRanda;miRNATAP -0.411129629446905 2.43654737649883e-31 hsa-miR-429 CDKN2B -0.142589289838583 0.802317907773415 0.0676204813199117 0.875382601126992 miRanda -0.161930481171186 1.19377952611012e-10 hsa-miR-429 RBL2 -0.142589289838583 0.802317907773415 -0.0695922475238753 0.906902559203765 miRanda -0.114178875200587 9.05972696116893e-14 hsa-miR-146b-5p PPP2R1B 0.00834882458611474 0.991577009242932 -0.00522798350256881 0.991408260059311 miRanda -0.141184532696467 1.00140046078863e-07 hsa-miR-146b-5p BMPR1B 0.00834882458611474 0.991577009242932 -0.134747300369366 0.797657104320608 miRanda -0.763779914564347 1.66236814877754e-11 hsa-miR-455-5p ZFYVE16 -0.196032525410701 0.627038966906064 -0.0555216392266296 0.91670112258897 miRanda;miRNATAP -0.246321294474187 8.44063734163612e-44 hsa-miR-455-5p THBS1 -0.196032525410701 0.627038966906064 -0.0068816911586822 0.993224588441564 miRanda -0.181790591068211 5.96114242364848e-09 hsa-miR-590-5p ZFYVE16 -0.131787544750195 0.684613701486826 -0.0555216392266296 0.91670112258897 miRanda -0.141719959875293 1.37577137023364e-13 hsa-miR-590-5p SP1 -0.131787544750195 0.684613701486826 -0.0580656653051959 0.929748914906324 miRanda -0.0510689803673186 0.000236070849230539 hsa-miR-590-5p THBS1 -0.131787544750195 0.684613701486826 -0.0068816911586822 0.993224588441564 miRanda;mirMAP -0.167667995453039 2.43506908893591e-07 hsa-miR-590-5p TGFB2 -0.131787544750195 0.684613701486826 -0.310431949258206 0.4589149484546 miRanda;miRNATAP -0.127583678067132 0.00859946694127918 hsa-miR-590-5p THBS2 -0.131787544750195 0.684613701486826 0.0420384090474553 0.953596062900646 miRanda -0.184580610139702 8.27333563753023e-06 hsa-miR-590-5p INHBB -0.131787544750195 0.684613701486826 0.100350180764804 0.830255421724205 miRanda -0.316300899501723 3.91367503989617e-14 hsa-miR-590-3p SMAD7 -0.133358268237272 0.535686159072243 -0.050137279965961 0.913873828853954 miRanda -0.104268769035866 1.5864687173614e-10 hsa-miR-590-3p TGFBR2 -0.133358268237272 0.535686159072243 -0.0248163256603231 0.968537582777159 miRanda -0.338025545666787 3.04278770804611e-20 hsa-miR-590-3p SMAD3 -0.133358268237272 0.535686159072243 -0.00805727245311783 0.987902560465751 miRanda -0.163099760014662 1.73477690677951e-13 hsa-miR-590-3p ZFYVE16 -0.133358268237272 0.535686159072243 -0.0555216392266296 0.91670112258897 miRanda -0.1316207265355 6.00534379257308e-11 hsa-miR-590-3p SMAD6 -0.133358268237272 0.535686159072243 -0.00809188507489367 0.969183109415995 miRanda -0.17590836322682 4.74377703172686e-10 hsa-miR-590-3p ACVR1 -0.133358268237272 0.535686159072243 -0.102018853336211 0.839021129058447 miRanda -0.108463868098368 7.42380935689782e-10 hsa-miR-590-3p GDF6 -0.133358268237272 0.535686159072243 0.127943908145237 0.526417832939525 miRanda;mirMAP -0.26694954665499 2.56785783669174e-08 hsa-miR-590-3p ACVR1C -0.133358268237272 0.535686159072243 -0.242633657325932 0.39426919694045 miRanda -0.580497974664095 4.97336103597514e-15 hsa-miR-590-3p BMPR1B -0.133358268237272 0.535686159072243 -0.134747300369366 0.797657104320608 miRanda;mirMAP -0.285771807763549 0.00802490630601688 hsa-miR-590-3p TGFB3 -0.133358268237272 0.535686159072243 0.111124424488611 0.835380319895798 miRanda -0.276040958504426 1.7943368211393e-16 hsa-miR-590-3p PITX2 -0.133358268237272 0.535686159072243 -0.063293467496382 0.757965460757416 miRanda -0.221058944956453 2.86214909987604e-05 hsa-miR-590-3p ID3 -0.133358268237272 0.535686159072243 0.141925561931471 0.760040401295001 miRanda -0.142133101437323 4.28063069242757e-07 hsa-miR-590-3p PPP2CB -0.133358268237272 0.535686159072243 0.0839352957265156 0.884120786282379 miRanda -0.10511834935696 4.0251015210593e-09 hsa-miR-590-3p THBS1 -0.133358268237272 0.535686159072243 -0.0068816911586822 0.993224588441564 miRanda -0.175386342682792 2.46112499417128e-07 hsa-miR-590-3p BMP4 -0.133358268237272 0.535686159072243 0.259009232032601 0.435488950825572 miRanda -0.488786644087842 1.20391215808401e-21 hsa-miR-590-3p RBL2 -0.133358268237272 0.535686159072243 -0.0695922475238753 0.906902559203765 miRanda -0.0970029371635654 1.57867143127506e-05 hsa-miR-590-3p FST -0.133358268237272 0.535686159072243 -0.0481855465289094 0.873185390251465 miRanda -0.46419329824237 4.76862887557746e-19 hsa-miR-590-3p THBS2 -0.133358268237272 0.535686159072243 0.0420384090474553 0.953596062900646 miRanda;mirMAP -0.165183001603145 0.000140989548326802 hsa-miR-590-3p INHBB -0.133358268237272 0.535686159072243 0.100350180764804 0.830255421724205 miRanda -0.374892224098306 7.33051194100577e-18 hsa-miR-542-3p MAPK3 0.11706603007597 0.867078497673182 0.120205298608796 0.83424265152562 miRanda -0.0580751735213389 0.00176871179177622 hsa-miR-542-3p PPP2CA 0.11706603007597 0.867078497673182 0.0284217367477391 0.96534362029265 miRanda -0.0549728706322074 0.000238114272024264 hsa-miR-542-3p RHOA 0.11706603007597 0.867078497673182 0.0333557466121839 0.967744764731311 miRanda -0.0731330266454587 7.5071633424253e-09 hsa-miR-320b TGFBR2 -0.0203395214664157 0.930562048282019 -0.0248163256603231 0.968537582777159 miRanda;miRNATAP -0.208017816637935 1.58734456312155e-08 hsa-miR-320b ZFYVE16 -0.0203395214664157 0.930562048282019 -0.0555216392266296 0.91670112258897 miRanda -0.10202400711679 3.26093935297166e-07 hsa-miR-320b ACVR1 -0.0203395214664157 0.930562048282019 -0.102018853336211 0.839021129058447 miRanda -0.0747238826335559 1.97644625789078e-05 hsa-miR-320b DCN -0.0203395214664157 0.930562048282019 0.00731810243205899 0.993040111761826 miRanda -0.29535554536257 7.09538047060049e-09 hsa-miR-320b THBS4 -0.0203395214664157 0.930562048282019 0.265649364147748 0.589449475741945 miRanda -0.430826287964397 1.28903705137441e-10 hsa-miR-142-5p CREBBP -0.35195621065247 0.488286772825655 -0.121528460671809 0.849036225288355 mirMAP -0.0601206980638462 2.52461125214428e-06 hsa-miR-186-5p CREBBP -0.14779866926096 0.840248407765158 -0.121528460671809 0.849036225288355 mirMAP;miRNATAP -0.0667157373336062 0.00172820290135309 hsa-miR-7-1-3p DCN -0.0332815306858167 0.935725386085843 0.00731810243205899 0.993040111761826 mirMAP -0.417482536233104 1.14965997799617e-17 hsa-miR-186-5p DCN -0.14779866926096 0.840248407765158 0.00731810243205899 0.993040111761826 mirMAP -0.232351831760879 0.000515456316071472 hsa-miR-374a-5p ZFYVE16 -0.0192159163584709 0.965315201402842 -0.0555216392266296 0.91670112258897 mirMAP -0.181696558684586 5.99235392938992e-09 hsa-miR-374b-5p ZFYVE16 -0.0341588728964348 0.947017013085837 -0.0555216392266296 0.91670112258897 mirMAP -0.173566050004311 1.61280527809941e-08 hsa-miR-495-3p RBL1 -0.159204559213757 0.555240058524588 -0.00762815276935669 0.980577451432883 mirMAP -0.0946164398614786 0.00360688128386921 hsa-miR-590-3p TGFB2 -0.133358268237272 0.535686159072243 -0.310431949258206 0.4589149484546 mirMAP -0.218778123275247 1.55472558560304e-05 hsa-miR-148a-5p MAPK1 -0.200917166615887 0.667057353234933 -0.0485161469138511 0.940405206700101 mirMAP -0.0717356392758089 4.03740535512022e-05 hsa-miR-17-3p MAPK1 -0.00462206849027691 0.994608252674318 -0.0485161469138511 0.940405206700101 mirMAP -0.0936083238119487 1.58257120633188e-07 hsa-miR-221-3p MAPK1 -0.0578227721969284 0.924067621219326 -0.0485161469138511 0.940405206700101 mirMAP -0.0501508967292743 0.00403384683530182 hsa-miR-29c-3p MAPK1 -0.0526710652467877 0.956320854458284 -0.0485161469138511 0.940405206700101 mirMAP -0.107930467813368 8.09848447187363e-09 hsa-miR-3913-5p MAPK1 -0.0522230839821796 0.748170987254748 -0.0485161469138511 0.940405206700101 mirMAP -0.145979254174869 5.54224263447113e-12 hsa-miR-660-5p MAPK1 0.0681681272574144 0.880554662781555 -0.0485161469138511 0.940405206700101 mirMAP -0.144747929471906 1.05117786154161e-13 hsa-miR-30a-5p BMP7 -0.315304933842571 0.81611555406281 0.205155019863216 0.498498426920493 mirMAP;miRNATAP -0.296828011310005 6.35417158979831e-08 hsa-miR-30c-5p BMP7 -0.268052278300344 0.753220585849573 0.205155019863216 0.498498426920493 mirMAP;miRNATAP -0.352978199901424 2.48460436378243e-05 hsa-miR-16-2-3p TGFBR1 -0.107555719075227 0.702302679752719 -0.141408193828913 0.803114596838615 mirMAP -0.0838776965180556 0.0010945013002878 hsa-miR-181c-5p TGFBR1 -0.18121298802215 0.718350072627076 -0.141408193828913 0.803114596838615 mirMAP;miRNATAP -0.0822784946678316 0.00406632441923034 hsa-miR-200b-3p TGFBR1 -0.109983892590611 0.891357972128093 -0.141408193828913 0.803114596838615 mirMAP -0.133382190063293 2.90573705377005e-11 hsa-miR-330-3p TGFBR1 -0.00366157141494194 0.98416704678615 -0.141408193828913 0.803114596838615 mirMAP;miRNATAP -0.0870374351390211 0.00129772155201813 hsa-miR-340-5p TGFBR1 0.0820090452273905 0.816484190854532 -0.141408193828913 0.803114596838615 mirMAP -0.126480744659732 2.00427959104962e-05 hsa-miR-34c-3p TGFBR1 0.130155071459505 0.516764839177917 -0.141408193828913 0.803114596838615 mirMAP -0.0646855533319358 0.00467252063603317 hsa-miR-500a-5p TGFBR1 0.0097790305601746 0.958449089566593 -0.141408193828913 0.803114596838615 mirMAP -0.0595365094697972 0.0160020892504 hsa-miR-664a-3p TGFBR1 0.0260321839026805 0.956434140422838 -0.141408193828913 0.803114596838615 mirMAP -0.0928356245084959 0.00398218374725522 hsa-miR-101-5p TGFBR1 -0.212753490668887 0.429456829560832 -0.141408193828913 0.803114596838615 mirMAP -0.0757482875997321 0.00610092225661458 hsa-miR-454-3p TGFBR1 -0.0807547300787816 0.779337172929459 -0.141408193828913 0.803114596838615 mirMAP;miRNATAP -0.060063203017321 0.010791037654236 hsa-miR-30a-5p RPS6KB1 -0.315304933842571 0.81611555406281 0.0179462515277296 0.972140340853137 mirMAP;miRNATAP -0.117644522086258 4.71701520431133e-10 hsa-miR-30c-5p RPS6KB1 -0.268052278300344 0.753220585849573 0.0179462515277296 0.972140340853137 mirMAP;miRNATAP -0.0886604780522647 0.0022079788042559 hsa-miR-340-5p RPS6KB1 0.0820090452273905 0.816484190854532 0.0179462515277296 0.972140340853137 mirMAP -0.12986566290195 6.5302066469287e-07 hsa-miR-340-5p BMP5 0.0820090452273905 0.816484190854532 0.00691135556347167 0.986142353723012 mirMAP -0.301115943990931 0.00419713980656556 hsa-miR-590-3p BMP5 -0.133358268237272 0.535686159072243 0.00691135556347167 0.986142353723012 mirMAP -0.431944392599325 2.99721483164888e-06 hsa-miR-186-5p PPP2CA -0.14779866926096 0.840248407765158 0.0284217367477391 0.96534362029265 mirMAP -0.0616775576387173 0.000579102189201237 hsa-miR-30e-5p PPP2CA -0.183864098532103 0.86939509445488 0.0284217367477391 0.96534362029265 mirMAP -0.0857929019748377 4.87885777798762e-05 hsa-miR-495-3p PPP2CA -0.159204559213757 0.555240058524588 0.0284217367477391 0.96534362029265 mirMAP -0.066863932380668 3.58715604589208e-08 hsa-miR-26a-5p SMAD5 -0.0558466394626773 0.953979749143751 -0.0546789038062157 0.922780020470417 mirMAP -0.0666672520501321 0.0403780875704886 hsa-miR-320b SMAD5 -0.0203395214664157 0.930562048282019 -0.0546789038062157 0.922780020470417 mirMAP -0.062970368186577 0.00119943158652796 hsa-miR-362-5p SMAD5 0.215268517371166 0.469421708227034 -0.0546789038062157 0.922780020470417 mirMAP -0.127604450522941 3.17271383110155e-13 hsa-miR-374a-5p SMAD5 -0.0192159163584709 0.965315201402842 -0.0546789038062157 0.922780020470417 mirMAP -0.160252655854768 1.24796945463573e-07 hsa-miR-374b-5p SMAD5 -0.0341588728964348 0.947017013085837 -0.0546789038062157 0.922780020470417 mirMAP -0.0965536486167079 0.00126792376759671 hsa-miR-500a-5p SMAD5 0.0097790305601746 0.958449089566593 -0.0546789038062157 0.922780020470417 mirMAP -0.159391338048836 1.57570963463228e-18 hsa-miR-16-2-3p ACVR1 -0.107555719075227 0.702302679752719 -0.102018853336211 0.839021129058447 mirMAP -0.0917592672846816 1.12664867583715e-07 hsa-miR-103a-3p BMP8B 0.0952235048222612 0.939840715516335 -0.353923600213929 0.116867182670808 mirMAP -0.225187088163204 0.00072552447723644 hsa-miR-150-5p BMP8B -0.38061861500346 0.649699545321307 -0.353923600213929 0.116867182670808 mirMAP -0.0578549838682133 0.0445384603492669 hsa-miR-362-5p BMP8B 0.215268517371166 0.469421708227034 -0.353923600213929 0.116867182670808 mirMAP -0.155746365237471 0.0002015321545365 hsa-let-7a-3p SMAD9 -0.130729276906521 0.779692030572974 -0.345301393083487 0.0749607019655454 mirMAP -0.339440208972422 2.31797137796656e-06 hsa-miR-16-2-3p SMAD9 -0.107555719075227 0.702302679752719 -0.345301393083487 0.0749607019655454 mirMAP -0.15099386534087 0.00371866896738571 hsa-miR-17-5p SMAD9 -0.0085894792332244 0.990927211793889 -0.345301393083487 0.0749607019655454 mirMAP -0.191658337518681 7.50740122113064e-05 hsa-miR-20a-5p SMAD9 0.0648697217907399 0.924634007033878 -0.345301393083487 0.0749607019655454 mirMAP -0.233520082362627 3.47290466993624e-06 hsa-miR-330-3p SMAD9 -0.00366157141494194 0.98416704678615 -0.345301393083487 0.0749607019655454 mirMAP;miRNATAP -0.202632761930593 0.000213705585293478 hsa-miR-590-3p SMAD9 -0.133358268237272 0.535686159072243 -0.345301393083487 0.0749607019655454 mirMAP -0.314485431663451 2.47706353518049e-09 hsa-miR-664a-3p SMAD9 0.0260321839026805 0.956434140422838 -0.345301393083487 0.0749607019655454 mirMAP -0.17306969418458 0.00803844869901249 hsa-miR-93-5p SMAD9 0.0554251653547535 0.959380932710413 -0.345301393083487 0.0749607019655454 mirMAP -0.539678071552204 1.29330103067119e-19 hsa-miR-29a-5p ACVR2A -0.242897712652954 0.339681975959217 0.0348825940608202 0.925897434335883 mirMAP;miRNATAP -0.0611047040253097 0.00804514609491625 hsa-miR-29b-2-5p ACVR2A -0.0126563776248076 0.980563872976574 0.0348825940608202 0.925897434335883 mirMAP -0.107651989989685 2.75376303318154e-07 hsa-miR-7-1-3p ACVR2A -0.0332815306858167 0.935725386085843 0.0348825940608202 0.925897434335883 mirMAP -0.0790957441050665 0.000127019700391499 hsa-miR-125b-2-3p INHBA -0.19521949049782 0.618072714328679 -0.00133229760725673 0.996966071744978 mirMAP -0.192569276917189 1.45917212337729e-05 hsa-miR-126-5p INHBA -0.0509133532389665 0.941546676673956 -0.00133229760725673 0.996966071744978 mirMAP -0.365446042383557 8.00635434475456e-10 hsa-miR-195-3p INHBA -0.0314657373015459 0.893921960533907 -0.00133229760725673 0.996966071744978 mirMAP -0.457507775640633 2.0024779119854e-15 hsa-miR-26a-5p INHBA -0.0558466394626773 0.953979749143751 -0.00133229760725673 0.996966071744978 mirMAP -0.806583685372971 2.83412051156283e-19 hsa-miR-26b-5p INHBA -0.165683456923659 0.842739329770527 -0.00133229760725673 0.996966071744978 mirMAP -0.386714706799185 7.94265255522648e-08 hsa-miR-30a-5p INHBA -0.315304933842571 0.81611555406281 -0.00133229760725673 0.996966071744978 mirMAP -0.339337086240446 5.62802453652228e-14 hsa-miR-30b-5p INHBA -0.126278303055191 0.871574517121767 -0.00133229760725673 0.996966071744978 mirMAP -0.488363240944963 2.76553416939545e-15 hsa-miR-30c-5p INHBA -0.268052278300344 0.753220585849573 -0.00133229760725673 0.996966071744978 mirMAP -0.554034099183663 5.80415262756076e-16 hsa-miR-30d-5p INHBA 0.00512174341017158 0.996390931509314 -0.00133229760725673 0.996966071744978 mirMAP -0.560261794318746 2.73850414996811e-12 hsa-miR-30e-5p INHBA -0.183864098532103 0.86939509445488 -0.00133229760725673 0.996966071744978 mirMAP -0.193445893339914 0.0222601575529368 hsa-miR-335-3p INHBA 0.248840023734261 0.661533599343062 -0.00133229760725673 0.996966071744978 mirMAP -0.358331308407745 2.90058922815416e-18 hsa-miR-374a-5p INHBA -0.0192159163584709 0.965315201402842 -0.00133229760725673 0.996966071744978 mirMAP -0.501460291948885 4.49896836409766e-09 hsa-miR-374b-5p INHBA -0.0341588728964348 0.947017013085837 -0.00133229760725673 0.996966071744978 mirMAP -0.423669398924089 4.99022706092223e-07 hsa-miR-381-3p INHBA -0.0215856799485721 0.961260144775191 -0.00133229760725673 0.996966071744978 mirMAP -0.118520102206024 0.024855760154819 hsa-miR-664a-3p INHBA 0.0260321839026805 0.956434140422838 -0.00133229760725673 0.996966071744978 mirMAP -0.329267118225509 1.28384451198929e-06 hsa-miR-7-1-3p ACVR1C -0.0332815306858167 0.935725386085843 -0.242633657325932 0.39426919694045 mirMAP -0.279361124975965 0.000101129261147657 hsa-miR-340-5p ROCK2 0.0820090452273905 0.816484190854532 -0.273205140377062 0.589812182930179 mirMAP -0.395127263389571 3.35868529258436e-20 hsa-miR-500a-5p ROCK2 0.0097790305601746 0.958449089566593 -0.273205140377062 0.589812182930179 mirMAP -0.0888322645165881 0.014849575176026 hsa-miR-30d-3p PPP2R1B 0.010689376681901 0.963707546423024 -0.00522798350256881 0.991408260059311 mirMAP -0.157184793756038 6.17261426855798e-07 hsa-miR-181a-5p THBS1 0.0637093750406734 0.945876131429707 -0.0068816911586822 0.993224588441564 mirMAP -0.150019822568732 0.000545990600769292 hsa-miR-181b-5p THBS1 0.0375130667115933 0.959555096276237 -0.0068816911586822 0.993224588441564 mirMAP -0.1533233095909 2.76267327611462e-05 hsa-miR-181c-5p THBS1 -0.18121298802215 0.718350072627076 -0.0068816911586822 0.993224588441564 mirMAP -0.147290024790751 7.4630964763336e-05 hsa-miR-186-5p THBS1 -0.14779866926096 0.840248407765158 -0.0068816911586822 0.993224588441564 mirMAP -0.0920033276158418 0.0367483805493002 hsa-miR-32-5p THBS1 -0.218686304292785 0.59094441655546 -0.0068816911586822 0.993224588441564 mirMAP -0.19932792247749 2.72222895176776e-08 hsa-miR-500a-5p THBS1 0.0097790305601746 0.958449089566593 -0.0068816911586822 0.993224588441564 mirMAP -0.167786316949011 1.51589228334337e-07 hsa-miR-142-5p BMPR1B -0.35195621065247 0.488286772825655 -0.134747300369366 0.797657104320608 mirMAP -0.444165525578716 8.90675105128216e-08 hsa-miR-23a-3p BMPR1B -0.0749136181048318 0.942312664607036 -0.134747300369366 0.797657104320608 mirMAP -0.54134602392377 0.000777327916413561 hsa-miR-26a-5p BMPR1B -0.0558466394626773 0.953979749143751 -0.134747300369366 0.797657104320608 mirMAP -0.502628260270685 0.004703613816135 hsa-miR-576-5p BMPR1B -0.111163544190811 0.739840245445557 -0.134747300369366 0.797657104320608 mirMAP -0.437349947086476 9.41645537856705e-05 hsa-miR-582-5p BMPR1B -0.25536438153407 0.299823930850699 -0.134747300369366 0.797657104320608 mirMAP;miRNATAP -0.25021027052656 0.0103283377253042 hsa-miR-106b-5p SMAD4 -0.0853499657102335 0.901700669947609 -0.0337260829637342 0.952673159973339 mirMAP;miRNATAP -0.132593131707842 2.60050027244317e-11 hsa-miR-141-3p SMAD4 -0.179420502124191 0.83354105481228 -0.0337260829637342 0.952673159973339 mirMAP -0.0665975031901977 4.1529973534957e-08 hsa-miR-142-5p SMAD4 -0.35195621065247 0.488286772825655 -0.0337260829637342 0.952673159973339 mirMAP -0.0749392072235979 1.78270524234105e-08 24895601 We identified three significantly associated mRNA-miRNA pairs: BCL2 was positively associated with miR-16 and SMAD4 was positively associated with miR-567 in the CRC tissue while MSH6 was positively associated with miR-142-5p in the normal tissue colorectal cancer hsa-miR-21-3p SMAD4 -0.103229815917794 0.915406989389524 -0.0337260829637342 0.952673159973339 mirMAP -0.142251679213528 1.79438322002583e-18 hsa-miR-32-5p SMAD4 -0.218686304292785 0.59094441655546 -0.0337260829637342 0.952673159973339 mirMAP -0.104053876543456 9.38449586813502e-09 hsa-miR-361-5p SMAD4 0.0775639231585332 0.909963521897996 -0.0337260829637342 0.952673159973339 mirMAP -0.13420862344236 0.000247319809078657 hsa-miR-369-3p SMAD4 -0.0734607425694875 0.755351791463265 -0.0337260829637342 0.952673159973339 mirMAP -0.0973232440468371 1.2339805788712e-08 hsa-miR-374a-5p SMAD4 -0.0192159163584709 0.965315201402842 -0.0337260829637342 0.952673159973339 mirMAP -0.0886712779160249 0.000913277124464415 hsa-miR-425-5p SMAD4 -0.179935054542016 0.805737521016457 -0.0337260829637342 0.952673159973339 mirMAP -0.0740108843152013 4.03711017781556e-06 hsa-miR-450b-5p SMAD4 0.140781738083346 0.700777724167455 -0.0337260829637342 0.952673159973339 mirMAP -0.087654088132823 1.06441835046281e-06 hsa-miR-493-5p SMAD4 -0.284749337378863 0.305440922291611 -0.0337260829637342 0.952673159973339 mirMAP -0.0692877234531395 2.7044003988377e-06 hsa-miR-500a-5p SMAD4 0.0097790305601746 0.958449089566593 -0.0337260829637342 0.952673159973339 mirMAP -0.0875827332136534 5.86614466503988e-08 hsa-miR-92b-3p SMAD4 -0.0975289498867111 0.871999313512183 -0.0337260829637342 0.952673159973339 mirMAP -0.0553219412443082 0.000805310824352674 hsa-miR-19a-3p CDKN2B -0.00951638786771092 0.980991306004163 0.0676204813199117 0.875382601126992 mirMAP -0.0729447798911564 0.0175649387980508 hsa-miR-19b-3p CDKN2B -0.0314903804749491 0.95913844863355 0.0676204813199117 0.875382601126992 mirMAP -0.0956519319507825 0.0110897095947599 hsa-miR-330-3p CDKN2B -0.00366157141494194 0.98416704678615 0.0676204813199117 0.875382601126992 mirMAP;miRNATAP -0.081206612055224 0.0327310364565687 hsa-miR-450b-5p CDKN2B 0.140781738083346 0.700777724167455 0.0676204813199117 0.875382601126992 mirMAP -0.154969260267371 5.41198999368989e-05 hsa-miR-590-3p BMP6 -0.133358268237272 0.535686159072243 -0.0629624972268548 0.790089529546855 mirMAP -0.141427399977376 0.00131871796494223 hsa-miR-141-5p GDF6 -0.21874832932521 0.789341690802864 0.127943908145237 0.526417832939525 mirMAP -0.215895062193741 8.08164935094237e-09 hsa-let-7a-3p INHBB -0.130729276906521 0.779692030572974 0.100350180764804 0.830255421724205 mirMAP -0.331545721479258 3.04305684692188e-08 hsa-let-7f-1-3p INHBB -0.222769653030984 0.176243975299018 0.100350180764804 0.830255421724205 mirMAP -0.256626544267918 4.74419192139722e-08 hsa-miR-130b-5p INHBB -0.24592404944858 0.439156866715699 0.100350180764804 0.830255421724205 mirMAP -0.308775024147184 3.2108494433814e-18 hsa-miR-340-5p TGFBR2 0.0820090452273905 0.816484190854532 -0.0248163256603231 0.968537582777159 mirMAP -0.314168975517319 6.41119882395371e-14 hsa-let-7g-3p SMAD3 -0.39123398731129 0.399100962252738 -0.00805727245311783 0.987902560465751 mirMAP -0.0672079683938065 7.19317852072924e-05 hsa-miR-186-5p SMAD3 -0.14779866926096 0.840248407765158 -0.00805727245311783 0.987902560465751 mirMAP -0.0873125857096575 0.00250614791235026 hsa-miR-212-3p SMAD3 0.0651691163056072 0.740903353495934 -0.00805727245311783 0.987902560465751 mirMAP -0.0653395375554603 0.00366958379656575 hsa-miR-320b SMAD3 -0.0203395214664157 0.930562048282019 -0.00805727245311783 0.987902560465751 mirMAP -0.0897586559244642 4.95206636155641e-05 hsa-miR-345-5p SMAD3 -0.318796500689201 0.40673094545688 -0.00805727245311783 0.987902560465751 mirMAP -0.0609568841496714 0.000251189661803762 hsa-miR-576-5p SMAD3 -0.111163544190811 0.739840245445557 -0.00805727245311783 0.987902560465751 mirMAP -0.0823118512650115 0.000420857426041599 hsa-miR-146b-5p SMAD2 0.00834882458611474 0.991577009242932 -0.0519399062136339 0.930776806456225 mirMAP -0.0784755866153152 1.40945643948323e-07 hsa-miR-181a-5p SMAD2 0.0637093750406734 0.945876131429707 -0.0519399062136339 0.930776806456225 mirMAP -0.115122429788219 8.47012412856965e-11 hsa-miR-181b-5p SMAD2 0.0375130667115933 0.959555096276237 -0.0519399062136339 0.930776806456225 mirMAP -0.112879931507918 3.62142519922135e-14 hsa-miR-26a-5p SMAD2 -0.0558466394626773 0.953979749143751 -0.0519399062136339 0.930776806456225 mirMAP -0.076216354764885 0.00103388430020276 hsa-miR-374a-3p SMAD2 -0.0781632437076389 0.926379383884834 -0.0519399062136339 0.930776806456225 mirMAP -0.0726506566736111 0.000894468846573258 hsa-miR-126-5p NOG -0.0509133532389665 0.941546676673956 -0.264314103066992 0.373098587786885 mirMAP;miRNATAP -0.166907094216349 0.00589468378929364 hsa-miR-16-1-3p SP1 -0.172993537212073 0.391863504419512 -0.0580656653051959 0.929748914906324 mirMAP -0.0652779480093862 4.66173648343276e-05 hsa-miR-181a-5p SP1 0.0637093750406734 0.945876131429707 -0.0580656653051959 0.929748914906324 mirMAP -0.170550722145103 3.8462533080952e-21 hsa-miR-181b-5p SP1 0.0375130667115933 0.959555096276237 -0.0580656653051959 0.929748914906324 mirMAP -0.162663427578237 6.39298452310672e-27 hsa-miR-181c-5p SP1 -0.18121298802215 0.718350072627076 -0.0580656653051959 0.929748914906324 mirMAP -0.0867777279199542 3.76183726041083e-08 hsa-miR-374a-3p SP1 -0.0781632437076389 0.926379383884834 -0.0580656653051959 0.929748914906324 mirMAP -0.135511716994984 1.52454394154091e-09 hsa-miR-3913-5p SP1 -0.0522230839821796 0.748170987254748 -0.0580656653051959 0.929748914906324 mirMAP -0.0947797865068882 1.95356069013202e-07 hsa-miR-532-5p SP1 0.0193679288578856 0.981424049788362 -0.0580656653051959 0.929748914906324 mirMAP -0.136379164595477 9.26014529036054e-13 hsa-miR-590-3p SP1 -0.133358268237272 0.535686159072243 -0.0580656653051959 0.929748914906324 mirMAP -0.0563062282945185 0.000106260791227243 hsa-miR-16-2-3p THBS2 -0.107555719075227 0.702302679752719 0.0420384090474553 0.953596062900646 mirMAP -0.266853998218325 2.47345099228546e-10 hsa-miR-320a THBS2 0.0425274543382255 0.958191670788918 0.0420384090474553 0.953596062900646 mirMAP -0.208219274662831 0.000550427836846861 hsa-miR-320b THBS2 -0.0203395214664157 0.930562048282019 0.0420384090474553 0.953596062900646 mirMAP -0.124670374856683 0.00370734965981903 hsa-miR-148a-5p BMPR2 -0.200917166615887 0.667057353234933 -0.138918726013816 0.828173765385504 mirMAP -0.120124264765292 3.51868525242609e-08 hsa-miR-148b-3p BMPR2 -0.121415535518017 0.85232232285121 -0.138918726013816 0.828173765385504 mirMAP -0.0681926998242813 0.0133862715928682 hsa-miR-16-2-3p BMPR2 -0.107555719075227 0.702302679752719 -0.138918726013816 0.828173765385504 mirMAP -0.0903286707710073 1.41954036072029e-05 hsa-miR-200b-3p BMPR2 -0.109983892590611 0.891357972128093 -0.138918726013816 0.828173765385504 mirMAP -0.121047661495268 8.73119456445721e-14 hsa-miR-200c-3p BMPR2 -0.0449560636499466 0.969433069399071 -0.138918726013816 0.828173765385504 mirMAP -0.13697648800764 1.55247615315968e-14 hsa-miR-30d-5p BMPR2 0.00512174341017158 0.996390931509314 -0.138918726013816 0.828173765385504 mirMAP -0.0903498646660299 0.003653275953354 hsa-miR-320b BMPR2 -0.0203395214664157 0.930562048282019 -0.138918726013816 0.828173765385504 mirMAP -0.0671950934839045 0.00141786614312316 hsa-miR-33a-5p BMPR2 -0.215117012664838 0.532123464324836 -0.138918726013816 0.828173765385504 mirMAP -0.0572554652021603 2.05818935736518e-05 hsa-miR-340-5p BMPR2 0.0820090452273905 0.816484190854532 -0.138918726013816 0.828173765385504 mirMAP -0.227147675302332 5.38594766443045e-22 hsa-miR-429 BMPR2 -0.142589289838583 0.802317907773415 -0.138918726013816 0.828173765385504 mirMAP;miRNATAP -0.12305207734683 1.41517075947211e-17 hsa-miR-96-5p BMPR2 -0.153312892459014 0.726115467443483 -0.138918726013816 0.828173765385504 mirMAP -0.0934614671967427 7.93602657299307e-10 hsa-miR-330-3p TGFB2 -0.00366157141494194 0.98416704678615 -0.310431949258206 0.4589149484546 miRNATAP -0.169099911709115 0.00123359688318399 hsa-miR-32-5p BMPR2 -0.218686304292785 0.59094441655546 -0.138918726013816 0.828173765385504 miRNATAP -0.174672112420236 3.33558378279438e-15 hsa-miR-30a-5p PPP2R1B -0.315304933842571 0.81611555406281 -0.00522798350256881 0.991408260059311 miRNATAP -0.0629574134561096 0.00225790081481894 hsa-miR-20b-5p TGFBR2 -0.275771697228234 0.506979861341138 -0.0248163256603231 0.968537582777159 miRNATAP -0.101055475114644 1.4278146071271e-05 hsa-miR-106b-5p TGFBR2 -0.0853499657102335 0.901700669947609 -0.0248163256603231 0.968537582777159 miRNATAP -0.583213497349775 2.44964235169299e-45 hsa-miR-106b-5p SMAD7 -0.0853499657102335 0.901700669947609 -0.050137279965961 0.913873828853954 miRNATAP -0.0784575934881882 3.97684846251125e-05 25286029 Smad7 which inhibits transforming growth factor-β TGF-β/Smad signaling as a target of the miR-106b family was downregulated in CD44+ cells stomach cancer hsa-miR-106b-5p BMP2 -0.0853499657102335 0.901700669947609 -0.222038347742825 0.284722031687683 miRNATAP -0.26660590164265 1.12724731726372e-05 hsa-miR-106b-5p EP300 -0.0853499657102335 0.901700669947609 -0.0381739592699031 0.951249053975231 miRNATAP -0.191649543350323 2.95239597393248e-13 hsa-miR-106a-5p SMAD7 -0.142040012764908 0.692192967482747 -0.050137279965961 0.913873828853954 miRNATAP -0.052764278775412 9.3963147572462e-05 hsa-miR-214-5p TFDP1 -0.143468551850718 0.734457173217684 0.014580908779898 0.980177571877553 miRNATAP -0.0801375690485228 0.000121371893028747 hsa-miR-330-5p ID1 -0.0582594636115701 0.896794748650637 -0.128748881044468 0.709093382117699 miRNATAP -0.286099397613906 1.45878882256605e-10 hsa-miR-374a-3p CREBBP -0.0781632437076389 0.926379383884834 -0.121528460671809 0.849036225288355 miRNATAP -0.118175129899399 3.92114134022804e-06 hsa-miR-218-5p RPS6KB1 -0.0827242549860268 0.862446853499361 0.0179462515277296 0.972140340853137 miRNATAP -0.15390061742019 1.35815707120652e-08 hsa-miR-93-5p SMAD7 0.0554251653547535 0.959380932710413 -0.050137279965961 0.913873828853954 miRNATAP -0.0700960219648226 0.000194109609348293 25371073;25371073 Mothers against decapentaplegic homolog 7 Smad7 as an essential molecular protein for nuclear accumulation of β-catenin in the canonical Wnt signaling pathway is predicted as a putative target gene of miR-93 by the silico method and demonstrated that it may be suppressed by targeting its 3'UTR;These findings showed that miR-93 suppresses colorectal cancer development via downregulating Wnt/β-catenin at least in part by targeting Smad7 ; colorectal cancer;colorectal cancer hsa-miR-200a-3p ACVR2A -0.192839143060886 0.77994979695622 0.0348825940608202 0.925897434335883 miRNATAP -0.142523834102645 2.08957993508987e-22 hsa-miR-200a-3p PITX2 -0.192839143060886 0.77994979695622 -0.063293467496382 0.757965460757416 miRNATAP -0.2225102743152 1.03072167409031e-09 hsa-miR-155-5p ACVR2A -0.167418736137707 0.822294484498835 0.0348825940608202 0.925897434335883 miRNATAP -0.07192757304313 0.000144380381259534 hsa-miR-542-3p RPS6KB1 0.11706603007597 0.867078497673182 0.0179462515277296 0.972140340853137 miRNATAP -0.146106785368595 3.33819415150885e-09 hsa-miR-589-5p SMAD4 -0.0214815940746442 0.967157138449855 -0.0337260829637342 0.952673159973339 miRNATAP -0.184456440754787 1.53364140974385e-13 hsa-miR-24-3p BMPR1B -0.156339520113363 0.865374272536865 -0.134747300369366 0.797657104320608 miRNATAP -0.924083329815397 2.27189205259187e-11 hsa-miR-181b-5p ACVR1C 0.0375130667115933 0.959555096276237 -0.242633657325932 0.39426919694045 miRNATAP -0.736387159640416 1.1522673578888e-20 hsa-miR-181b-5p BMPR2 0.0375130667115933 0.959555096276237 -0.138918726013816 0.828173765385504 miRNATAP -0.224720984868525 5.95101149780694e-24 hsa-miR-196b-5p CHRD -0.339377433567605 0.635151980425286 0.0538554939791851 0.885642347857914 miRNATAP -0.21439911483115 1.94841963347834e-07 hsa-miR-29b-3p ACVR2A -0.147629200668355 0.855068431567557 0.0348825940608202 0.925897434335883 miRNATAP -0.203237419946028 3.36234269209612e-17 hsa-miR-590-5p ACVR2A -0.131787544750195 0.684613701486826 0.0348825940608202 0.925897434335883 miRNATAP -0.0652583385141474 0.00158803496584424 hsa-miR-148a-3p GDF6 -0.184595009730559 0.892714155682155 0.127943908145237 0.526417832939525 miRNATAP -0.209173958939414 2.08641938433008e-05 hsa-miR-361-3p SMAD2 -0.0127254134873924 0.984476698818773 -0.0519399062136339 0.930776806456225 miRNATAP -0.128521633108847 3.38235989722682e-08 hsa-miR-30d-3p PITX2 0.010689376681901 0.963707546423024 -0.063293467496382 0.757965460757416 miRNATAP -0.332002742964576 6.35544311038629e-07 hsa-miR-30d-3p GDF6 0.010689376681901 0.963707546423024 0.127943908145237 0.526417832939525 miRNATAP -0.286565347127467 2.41745328700732e-06 hsa-miR-34a-5p SMAD4 -0.00150684423480296 0.998107346259152 -0.0337260829637342 0.952673159973339 miRNATAP -0.0970813582287062 0.000114939393150447 hsa-miR-26a-5p LTBP1 -0.0558466394626773 0.953979749143751 -0.0847739199441895 0.876948200966833 miRNATAP -0.132224939088067 0.0191280702092279 hsa-miR-183-5p ACVR2A -0.0285894962233133 0.980944848059819 0.0348825940608202 0.925897434335883 miRNATAP -0.143429776860837 1.10115003008173e-18 hsa-miR-21-5p ACVR2A 0.0148493782366828 0.992419670576308 0.0348825940608202 0.925897434335883 miRNATAP -0.228019435065362 1.72805692634805e-21 hsa-miR-197-3p MAPK3 -0.16253774958271 0.828233346204688 0.120205298608796 0.83424265152562 miRNATAP -0.106370513582673 1.47526386613596e-08 hsa-miR-30d-5p PPP2R1B 0.00512174341017158 0.996390931509314 -0.00522798350256881 0.991408260059311 miRNATAP -0.0739131720495206 0.0432717400554516 hsa-miR-30d-5p ACVR2A 0.00512174341017158 0.996390931509314 0.0348825940608202 0.925897434335883 miRNATAP -0.0639120995466507 0.0429878874336958 hsa-miR-92b-3p BMPR2 -0.0975289498867111 0.871999313512183 -0.138918726013816 0.828173765385504 miRNATAP -0.0974248782164534 1.59413139070508e-06 hsa-miR-205-5p BMPR1B -0.557475268128561 0.565924480985698 -0.134747300369366 0.797657104320608 miRNATAP -0.128948367199523 0.00663542809472005 hsa-miR-142-5p NOG -0.35195621065247 0.488286772825655 -0.264314103066992 0.373098587786885 miRNATAP -0.14733740273363 0.000713947895715875 hsa-let-7b-3p ID2 -0.287127027685606 0.565601265486799 0.0168726689782535 0.975198394302871 miRNATAP -0.0732895359665089 0.00104384467987758 hsa-miR-769-5p BMPR2 -0.10362464632991 0.793365222563107 -0.138918726013816 0.828173765385504 miRNATAP -0.105758705299915 0.000232905961375314 hsa-miR-769-5p SMAD3 -0.10362464632991 0.793365222563107 -0.00805727245311783 0.987902560465751 miRNATAP -0.121091427985316 6.14487597806327e-05 hsa-miR-19a-3p INHBB -0.00951638786771092 0.980991306004163 0.100350180764804 0.830255421724205 miRNATAP -0.249766887068599 8.51257274377858e-12 hsa-miR-19b-3p INHBB -0.0314903804749491 0.95913844863355 0.100350180764804 0.830255421724205 miRNATAP -0.245341846364512 5.22835551023035e-08 hsa-miR-200c-3p ACVR2A -0.0449560636499466 0.969433069399071 0.0348825940608202 0.925897434335883 miRNATAP -0.155691181802949 5.31342226529533e-18 hsa-miR-26b-5p LTBP1 -0.165683456923659 0.842739329770527 -0.0847739199441895 0.876948200966833 miRNATAP -0.143867739059559 0.00122143259712523 hsa-miR-532-5p SMAD5 0.0193679288578856 0.981424049788362 -0.0546789038062157 0.922780020470417 miRNATAP -0.193902491520723 5.50007562180344e-14 hsa-miR-20a-5p EP300 0.0648697217907399 0.924634007033878 -0.0381739592699031 0.951249053975231 miRNATAP -0.151748232339608 1.59846335234487e-12 hsa-miR-301a-3p ACVR2A -0.0522829902990942 0.861546852981366 0.0348825940608202 0.925897434335883 miRNATAP -0.0990588352018877 4.47282391755108e-10 hsa-miR-301a-3p INHBB -0.0522829902990942 0.861546852981366 0.100350180764804 0.830255421724205 miRNATAP -0.257370391267214 1.82089541732649e-15 hsa-miR-301a-3p TGFBR2 -0.0522829902990942 0.861546852981366 -0.0248163256603231 0.968537582777159 miRNATAP -0.317266296975964 1.73201531962553e-32 hsa-miR-654-3p TNF -0.187928566892617 0.631807992098329 -0.585975280957927 0.00235534467531092 miRNATAP -0.0898613497311195 0.032614161742769 hsa-miR-429 ZFYVE9 -0.142589289838583 0.802317907773415 -0.12199434575654 0.788138337240637 miRNATAP -0.138287827425906 2.91796972669215e-13 hsa-miR-429 ACVR1 -0.142589289838583 0.802317907773415 -0.102018853336211 0.839021129058447 miRNATAP -0.119553302184784 1.14526847802397e-23 hsa-miR-429 TGFBR2 -0.142589289838583 0.802317907773415 -0.0248163256603231 0.968537582777159 miRNATAP -0.404995702801572 1.14853648012577e-64 hsa-miR-429 TGFB2 -0.142589289838583 0.802317907773415 -0.310431949258206 0.4589149484546 miRNATAP -0.113931562701627 0.00112595441618086 hsa-miR-429 INHBB -0.142589289838583 0.802317907773415 0.100350180764804 0.830255421724205 miRNATAP -0.210500602533215 3.36016908073308e-12 hsa-miR-429 BMP2 -0.142589289838583 0.802317907773415 -0.222038347742825 0.284722031687683 miRNATAP -0.40826129557167 7.17935100433753e-32 hsa-miR-429 SMAD3 -0.142589289838583 0.802317907773415 -0.00805727245311783 0.987902560465751 miRNATAP -0.102063359852527 2.55000912428033e-11 hsa-miR-508-3p TGFBR2 -0.000309617571689902 0.999135648467985 -0.0248163256603231 0.968537582777159 miRNATAP -0.077002775791948 0.00114780208414613 hsa-miR-331-5p ACVR1C -0.143249163277681 0.38317955643253 -0.242633657325932 0.39426919694045 miRNATAP -0.604316750970958 1.40966126146655e-11 hsa-miR-331-5p TGFB2 -0.143249163277681 0.38317955643253 -0.310431949258206 0.4589149484546 miRNATAP -0.256828592209254 2.39839780265118e-05 hsa-miR-29c-3p ACVR2A -0.0526710652467877 0.956320854458284 0.0348825940608202 0.925897434335883 miRNATAP -0.138823667480276 5.19803499835417e-09 hsa-let-7f-5p TGFBR1 -0.052676842774197 0.963441505261455 -0.141408193828913 0.803114596838615 miRNATAP -0.0759899219327198 0.0211990158900523 hsa-let-7d-5p ACVR2A -0.176960380407253 0.795858406343421 0.0348825940608202 0.925897434335883 miRNATAP -0.0631211552814453 0.033894092349033 hsa-miR-340-5p SMAD7 0.0820090452273905 0.816484190854532 -0.050137279965961 0.913873828853954 miRNATAP -0.0715024350427874 0.000121716607364627 hsa-miR-25-3p BMPR2 0.0550592306329012 0.962829613775088 -0.138918726013816 0.828173765385504 miRNATAP -0.22770448332314 2.41816718314955e-11 hsa-miR-455-3p CHRD -0.332546859679539 0.617979023781481 0.0538554939791851 0.885642347857914 miRNATAP -0.391985696776891 3.45537050249205e-26 hsa-miR-181c-5p ACVR1C -0.18121298802215 0.718350072627076 -0.242633657325932 0.39426919694045 miRNATAP -0.582612994724267 6.82133958480936e-13 hsa-miR-130a-3p RPS6KB1 -0.19782843294836 0.720491845034151 0.0179462515277296 0.972140340853137 miRNATAP -0.0654255109839751 0.00274263780515335 hsa-miR-130a-3p BMPR1B -0.19782843294836 0.720491845034151 -0.134747300369366 0.797657104320608 miRNATAP -0.468510027326227 3.72612678298247e-06 hsa-miR-27a-3p ACVR2A -0.0713791016390708 0.936296470694396 0.0348825940608202 0.925897434335883 miRNATAP -0.0651020435107769 0.031219805398818 hsa-miR-671-5p BMPR2 0.0238736022615038 0.908889383230195 -0.138918726013816 0.828173765385504 miRNATAP -0.189454100614002 3.2885754867585e-22 hsa-miR-185-5p ACVR2A 0.0659414824247602 0.896134370932431 0.0348825940608202 0.925897434335883 miRNATAP -0.307434790887798 1.14081881563322e-21 hsa-miR-9-5p TGFBR2 0.513826958284847 0.574325590140814 -0.0248163256603231 0.968537582777159 miRNATAP -0.11967052909348 2.52866655443074e-10 hsa-miR-9-5p INHBB 0.513826958284847 0.574325590140814 0.100350180764804 0.830255421724205 miRNATAP -0.0729501463686517 0.0012406123989602 hsa-miR-9-5p THBS2 0.513826958284847 0.574325590140814 0.0420384090474553 0.953596062900646 miRNATAP -0.0617363143607876 0.00529555820135518 hsa-miR-28-5p SMAD3 -0.212713060051394 0.714914931441106 -0.00805727245311783 0.987902560465751 miRNATAP -0.120097254990824 0.00200641803458376 hsa-miR-15a-5p ACVR2B 0.027476192963463 0.965257307327948 -0.152487710062183 0.689782894367425 miRNATAP -0.175444464601842 3.65634075266698e-08 hsa-miR-450b-5p SKP1 0.140781738083346 0.700777724167455 0.11984894684252 0.870895899955478 miRNATAP -0.0607116247078892 0.00058405407540698 hsa-miR-450b-5p RPS6KB1 0.140781738083346 0.700777724167455 0.0179462515277296 0.972140340853137 miRNATAP -0.0714042541539022 0.00314901381404868 hsa-let-7e-5p ACVR2A 0.0357092208790988 0.968612511131967 0.0348825940608202 0.925897434335883 miRNATAP -0.110838593636447 0.000569208718270341 hsa-miR-181a-5p ACVR1C 0.0637093750406734 0.945876131429707 -0.242633657325932 0.39426919694045 miRNATAP -0.620562379709194 5.89125073509107e-11 hsa-miR-181a-5p BMPR2 0.0637093750406734 0.945876131429707 -0.138918726013816 0.828173765385504 miRNATAP -0.224587920836486 3.17918043865356e-17 hsa-miR-130b-3p ACVR2A -0.211426879967744 0.486104856445712 0.0348825940608202 0.925897434335883 miRNATAP -0.128088696638873 2.25428516577612e-10 hsa-miR-130b-3p INHBB -0.211426879967744 0.486104856445712 0.100350180764804 0.830255421724205 miRNATAP -0.381630575170115 9.92225932758929e-21 hsa-miR-130b-3p BMPR1B -0.211426879967744 0.486104856445712 -0.134747300369366 0.797657104320608 miRNATAP -0.330771696537828 0.00111424679509253 hsa-miR-454-3p TGFBR2 -0.0807547300787816 0.779337172929459 -0.0248163256603231 0.968537582777159 miRNATAP -0.384614615164931 1.36686238358356e-32 hsa-miR-454-3p ACVR2A -0.0807547300787816 0.779337172929459 0.0348825940608202 0.925897434335883 miRNATAP -0.137225049020457 7.85807508870824e-13 hsa-miR-454-3p INHBB -0.0807547300787816 0.779337172929459 0.100350180764804 0.830255421724205 miRNATAP -0.300070731677732 2.01102414021318e-14 hsa-miR-326 ID1 -0.134657725127161 0.690379143543161 -0.128748881044468 0.709093382117699 miRNATAP -0.0947412089412218 0.000280962870256018