miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-130b-5p	BMP7	0.170599813152408	0.337611586432771	0.826802462156244	0.0488671273441991	mirMAP	-0.318132163788707	0.00583072092537794		NA	NA	NA
hsa-miR-1976	BMP7	-0.431472440543166	0.00324575010550946	0.826802462156244	0.0488671273441991	MirTarget	-0.453184137513286	0.0011534801443726		NA	NA	NA
hsa-miR-22-3p	BMP7	-0.628561621952407	1.33755558015523e-09	0.826802462156244	0.0488671273441991	miRNAWalker2_validate;miRTarBase	-0.870526640067938	7.19988594035658e-06		NA	NA	NA
hsa-miR-30a-5p	BMP7	-0.626257932887855	0.000108198196973765	0.826802462156244	0.0488671273441991	mirMAP;miRNATAP	-0.347549267695056	0.00579249244441942		NA	NA	NA
hsa-miR-30e-5p	BMP7	-0.627815042856657	3.02205690184908e-10	0.826802462156244	0.0488671273441991	mirMAP	-0.577684399384162	0.00443944182643628		NA	NA	NA
hsa-miR-34a-5p	BMP7	1.03694231790865	5.74864019540594e-14	0.826802462156244	0.0488671273441991	miRNAWalker2_validate	-0.454356184389064	0.00161959499114198		NA	NA	NA
hsa-miR-616-5p	BMP7	0.150569904638223	0.402836556304524	0.826802462156244	0.0488671273441991	mirMAP	-0.332806313369365	0.00359782816716627		NA	NA	NA
hsa-miR-330-3p	CTNNB1	-0.332364259424489	0.0316051913061459	0.00180452674840392	0.983564078864382	MirTarget;PITA;miRNATAP	-0.128940103294471	3.76576237893285e-06		NA	NA	NA
hsa-miR-331-3p	CTNNB1	-0.283974346994635	0.0373785411053202	0.00180452674840392	0.983564078864382	miRNAWalker2_validate	-0.113207881387487	0.000273720190926097		NA	NA	NA
hsa-miR-335-5p	CUL7	-1.61347836513558	1.62757083289711e-19	1.13121696109628	5.17561490465219e-27	miRNAWalker2_validate	-0.122728492918852	2.38145414523056e-05		NA	NA	NA
hsa-miR-139-5p	FAM83D	-2.11299531796557	8.16407076415038e-28	2.33803155229483	1.09911702307113e-30	miRanda	-0.403180965751654	6.1623594830282e-16		NA	NA	NA
hsa-miR-142-3p	FAM83D	-1.4243101967815	1.92609481097765e-14	2.33803155229483	1.09911702307113e-30	miRanda	-0.243870406974125	9.73981462765e-06		NA	NA	NA
hsa-miR-429	FAM83D	-1.40262535827285	6.93982219171912e-05	2.33803155229483	1.09911702307113e-30	miRanda	-0.120268736846897	6.9201322686435e-05		NA	NA	NA
hsa-miR-486-5p	FAM83D	-1.77766890600022	2.9071717929922e-14	2.33803155229483	1.09911702307113e-30	miRanda	-0.119396057702422	0.00684983133497221		NA	NA	NA
hsa-miR-107	FGFR2	0.241662461253461	0.0170788899505389	-2.28582334954307	1.14765468936708e-05	PITA;miRanda	-0.690301810710163	0.0068857261082219		NA	NA	NA
hsa-miR-26b-5p	FOXF2	-1.10804856399744	4.14176110314282e-22	1.42606844181825	1.02893636282949e-06	miRNAWalker2_validate	-0.551051515054793	3.6558925931639e-06		NA	NA	NA
hsa-miR-3607-3p	FOXF2	-2.15518588554493	1.03390728226728e-23	1.42606844181825	1.02893636282949e-06	miRNATAP	-0.31347448567967	5.76999285090051e-07		NA	NA	NA
hsa-miR-590-3p	FOXF2	-0.473167498047808	1.76652934637227e-05	1.42606844181825	1.02893636282949e-06	PITA;miRanda	-0.396597341456346	0.00235927220330873		NA	NA	NA
hsa-miR-29b-3p	GSK3B	-0.348885528720517	0.0121441341291285	0.11314223970595	0.0774493616232908	miRTarBase;miRNATAP	-0.106852381323571	1.32787261855633e-06		NA	NA	NA
hsa-miR-342-3p	GSK3B	-0.319677314984262	0.0449813878317147	0.11314223970595	0.0774493616232908	miRanda	-0.106989468297279	2.44530655156687e-08		NA	NA	NA
hsa-miR-224-3p	HGF	1.40770116795301	1.31426607144612e-08	-3.45738625921135	1.44942707549128e-24	mirMAP	-0.24700467708681	0.000422016473692453		NA	NA	NA
hsa-miR-30d-5p	HGF	0.718283816348023	2.47422074061352e-08	-3.45738625921135	1.44942707549128e-24	mirMAP	-0.636747615843547	1.6663430655982e-06		NA	NA	NA
hsa-miR-3682-3p	HGF	0.805600143458555	8.7874424633131e-06	-3.45738625921135	1.44942707549128e-24	mirMAP	-0.322825191529333	0.00118766446680551		NA	NA	NA
hsa-miR-421	HGF	0.941856334694081	6.12167297054077e-08	-3.45738625921135	1.44942707549128e-24	miRanda	-0.37483532054751	0.00015557960010186		NA	NA	NA
hsa-miR-616-5p	HGF	0.150569904638223	0.402836556304524	-3.45738625921135	1.44942707549128e-24	mirMAP	-0.329885938670236	0.000709899554621757		NA	NA	NA
hsa-miR-107	HIF1A	0.241662461253461	0.0170788899505389	-0.366176828296648	0.0111002186054683	miRNAWalker2_validate;miRTarBase;miRanda	-0.436710343430652	2.03313957855482e-10		NA	NA	NA
hsa-miR-17-5p	HIF1A	0.698861147045461	2.43854106455398e-05	-0.366176828296648	0.0111002186054683	miRTarBase;MirTarget;TargetScan	-0.207486649592262	6.73419034465465e-07		NA	NA	NA
hsa-miR-20a-5p	HIF1A	0.854326758727003	5.04256669663285e-07	-0.366176828296648	0.0111002186054683	miRNAWalker2_validate;miRTarBase;MirTarget	-0.245558453559623	9.83134714947215e-10	22901144	Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha		breast cancer
hsa-miR-33a-5p	HIF1A	-0.767474460958522	1.09948756118522e-05	-0.366176828296648	0.0111002186054683	miRNAWalker2_validate	-0.107227499920455	0.00730487730363833		NA	NA	NA
hsa-miR-616-5p	HIF1A	0.150569904638223	0.402836556304524	-0.366176828296648	0.0111002186054683	MirTarget	-0.124976106072862	0.00144238259369066		NA	NA	NA
hsa-miR-660-5p	HIF1A	0.989755850734071	5.69930767464937e-14	-0.366176828296648	0.0111002186054683	MirTarget	-0.249870386379118	1.21860559731773e-06		NA	NA	NA
hsa-miR-93-5p	HIF1A	1.39518349670953	2.84167728726712e-25	-0.366176828296648	0.0111002186054683	MirTarget	-0.173769064325932	0.000425501783480084		NA	NA	NA
hsa-let-7b-3p	HMGA2	-1.21979213547786	5.84575581584603e-17	1.11519648679255	0.015940340984894	mirMAP	-0.931679642757753	2.09567681737869e-10	20949044;18413822;23073586;21598109;24612219;23700794;21412931	Since let-7 miRNAs generally play a tumor-suppressive role as targeting oncogenes such as RAS and HMGA2 our results suggest that AZ-P7a cells release let-7 miRNAs via exosomes into the extracellular environment to maintain their oncogenesis;Recent studies report that HMGA2 is negatively regulated by the let-7 microRNA miRNA family; However no studies have examined the clinical significance of HMGA2 and its relationship to the let-7 miRNA family in gastric cancer; We also did an association study comparing HMGA2 expression and let-7 miRNA family expression in gastric cancer; Furthermore our findings suggest that HMGA2 is negatively regulated by the let-7 miRNA family in human gastric cancer;HMGA2 mRNA and let-7 family microRNA were detected by real time fluorescent quantitative reverse transcription polymerase chain reaction in the corresponding frozen tissues; All let-7 family members were detectable in all ovarian cancer samples and their expression were inversely correlated with HMGA2 mRNA expression r=-0.305P<0.05; The downregulation of let-7 is but not the only mechanism of HMGA2 overexpression in serous ovarian cancer;Role of microRNA let 7 and effect to HMGA2 in esophageal squamous cell carcinoma; To investigated the role of microRNA miRNA let-7 and its regulation on high mobility group A2 HMGA2 protein expression in esophageal squamous cell carcinoma ESCC; To evaluate the role of let-7 and HMGA2 cell proliferations were analyzed with synthetic let-7 mimics- or its inhibitor-transfected cells; The transcription of let-7 inversely correlated with HMGA2 protein; The present results demonstrated that let-7 and HMGA2 involved in ESCC carcinogenesis;HMGA2 is down regulated by microRNA let 7 and associated with epithelial mesenchymal transition in oesophageal squamous cell carcinomas of Kazakhs; To investigate the expression of let-7 and its regulation of high-mobility group A2 protein HMGA2 and to verify the relationship between let-7 HMGA2 and the process of epithelial-mesenchymal transition EMT in oesophageal squamous cell carcinomas OSCC of Kazakh patients; Let-7 could repress expression of HMGA2 after co-transfection with let-7 and HMGA2 P = 0.002; Moreover let-7 expression was observed less frequently P = 2.0 × 10-8  and HMGA2 expression more frequently P = 1.0 × 10-10  in OSCC than in normal adjacent tissues; and let-7 expression was observed less frequently in OSCC from Kazakh patients than in those from Han and Uygur patients P = 0.041; There was a reverse correlation between expression of let-7 and HMGA2 P = 0.018; Expression of let-7 can suppress cell proliferation by acting directly on regulation of HMGA2 in OSCC;MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells;Let 7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data; The aim of our study was first to assess the role of HMGA2 expression in the pathogenesis of adipocytic tumors AT and second to seek a potential correlation between overexpression of HMGA2 and let-7 expression inhibition by analyzing a series of 56 benign and malignant AT with molecular cytogenetic data; We measured the levels of expression of HMGA2 mRNA and of eight members of the let-7 microRNA family using quantitative RT-PCR and expression of HMGA2 protein using immunohistochemistry; Although overexpression of both HMGA2 mRNA and protein in a majority of ordinary lipomas without HMGA2 structural rearrangement may have suggested a potential role for let-7 microRNAs we did not observe a significant link with let-7 inhibition in such cases	;;;tumorigenesis;;;malignant trasformation	gastric cancer;gastric cancer;ovarian cancer;esophageal cancer;esophageal cancer;lung cancer;sarcoma
hsa-let-7c-5p	HMGA2	-1.70744661345097	2.87934212005942e-20	1.11519648679255	0.015940340984894	miRNAWalker2_validate;miRTarBase;MirTarget	-0.682135030438129	2.57681307834063e-09		NA	NA	NA
hsa-let-7g-5p	HMGA2	-0.461294133285527	2.17210114729901e-05	1.11519648679255	0.015940340984894	miRNAWalker2_validate;miRTarBase;MirTarget	-0.716004367224465	0.000555928125969053	21472347;18308936	Furthermore K-Ras and HMGA2 are well known as targets of let-7g; In this study we evaluated the potential role of precursor pre-let-7g in lung cancer cell metastasis focusing on the two targets of let-7g HMGA2 and K-Ras;In let-7g expressing tumors reductions in Ras family and HMGA2 protein levels were detected; Ectopic expression of K-RasG12D largely rescued let-7g mediated tumor suppression whereas ectopic expression of HMGA2 was less effective	metastasis;	lung cancer;lung cancer
hsa-miR-125b-2-3p	HMGA2	-1.6609436107315	5.71534047969855e-18	1.11519648679255	0.015940340984894	mirMAP	-0.5687135978767	3.52276705032182e-07		NA	NA	NA
hsa-miR-125b-5p	HMGA2	-1.35767721102906	1.16564617395164e-18	1.11519648679255	0.015940340984894	miRNAWalker2_validate;miRTarBase	-0.768807860528197	3.11381898043281e-08		NA	NA	NA
hsa-miR-148a-5p	HMGA2	-0.767626696027761	1.08359477494797e-06	1.11519648679255	0.015940340984894	mirMAP	-0.657849544386419	3.03990369970668e-06		NA	NA	NA
hsa-miR-195-3p	HMGA2	-1.09375690196245	4.70092324819807e-09	1.11519648679255	0.015940340984894	mirMAP	-0.515289265278645	1.6713059819059e-05		NA	NA	NA
hsa-miR-195-5p	HMGA2	-1.85907534356434	1.47434041676402e-22	1.11519648679255	0.015940340984894	MirTarget	-0.67370658743728	1.13883641249535e-09		NA	NA	NA
hsa-miR-30a-3p	HMGA2	-1.52720594401486	1.3830066075708e-17	1.11519648679255	0.015940340984894	MirTarget	-0.449199831088698	0.000203326433484111		NA	NA	NA
hsa-miR-30a-5p	HMGA2	-0.626257932887855	0.000108198196973765	1.11519648679255	0.015940340984894	mirMAP	-0.455437332409256	0.00102838503480712		NA	NA	NA
hsa-miR-30e-3p	HMGA2	-1.20845647373031	3.10263633528203e-25	1.11519648679255	0.015940340984894	MirTarget	-0.765503937451092	2.7727345944492e-05		NA	NA	NA
hsa-miR-30e-5p	HMGA2	-0.627815042856657	3.02205690184908e-10	1.11519648679255	0.015940340984894	mirMAP	-0.798500838474147	0.000352279983828195		NA	NA	NA
hsa-miR-33b-5p	HMGA2	-2.28852395459234	2.69046626645242e-22	1.11519648679255	0.015940340984894	MirTarget	-0.396935736295752	1.26377908941702e-05	27609581;25868853;25725129	The expression and significance of miR 33b and HMGA2 in esophageal squamous cell carcinoma; Objective To investigate the expression and significance of miR-33b and high mobility group AT-hook 2 HMGA2 in esophageal squamous cell carcinoma ESCC; Methods Real-time quantitative PCR qRT-PCR was used to detect the expression levels of miR-33b and HMGA2 mRNA from the ESCC and adjacent tissues; After the miR-33b mimics inhibitor and controls were separately transfected into TE-1 and Eca-109 cells the expression levels of miR-33b and HMGA2 in each group were again determined by qRT-PCR and Western blotting; The expression level of miR-33b in the HMGA2 positive group was lower than that in the HMGA2 negative group; The correlation analysis showed that the expression of miR-33b was negatively correlated with the mRNA expression of HMGA2 in the ESCC tissues; There were no significant difference in the mRNA expression of HMGA2 among the cells transfected separately with miR-33b mimics inhibitor and controls but Western blotting indicated that the protein expression of HMGA2 decreased significantly in the miR-33b over-expressed cells; Conclusion The expression of miR-33b decreases and HMGA2 increases in the ESCC tissues;By targeting HMGA2 and Twist1 miR-33b attenuated melanoma migration and invasiveness upon cordycepin exposure;MicroRNA 33b upregulated by EF24 a curcumin analog suppresses the epithelial to mesenchymal transition EMT and migratory potential of melanoma cells by targeting HMGA2; miR-33b directly bound to HMGA2 3' untranslated region 3'-UTR to suppress its expression as measured by dual-luciferase assay; Thus the results suggest that EF24 suppresses melanoma metastasis via upregulating miR-33b and concomitantly reducing HMGA2 expression	;;metastasis	esophageal cancer;melanoma;melanoma
hsa-miR-34a-5p	HMGA2	1.03694231790865	5.74864019540594e-14	1.11519648679255	0.015940340984894	miRNAWalker2_validate	-0.544514172218724	0.000610403792176777	18803879	miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making	poor survival;differentiation	gastric cancer
hsa-miR-3607-3p	HMGA2	-2.15518588554493	1.03390728226728e-23	1.11519648679255	0.015940340984894	mirMAP	-0.308271979274254	0.00190249533710306		NA	NA	NA
hsa-miR-497-5p	HMGA2	-1.41371173021948	7.09278946477743e-17	1.11519648679255	0.015940340984894	MirTarget	-0.758336990454361	1.93445495570777e-09		NA	NA	NA
hsa-let-7a-3p	LEF1	-0.568717557554068	1.00947202557819e-07	2.65801616612257	2.07740338608884e-15	miRNATAP	-0.639538499404186	4.40051133869843e-05		NA	NA	NA
hsa-let-7b-3p	LEF1	-1.21979213547786	5.84575581584603e-17	2.65801616612257	2.07740338608884e-15	miRNATAP	-0.67397556538713	8.7442482981614e-10		NA	NA	NA
hsa-miR-193b-3p	LEF1	-0.166697207281748	0.272022543069482	2.65801616612257	2.07740338608884e-15	miRNAWalker2_validate	-0.526045563134031	2.1073127312606e-06		NA	NA	NA
hsa-miR-217	LEF1	1.05797297540381	0.0401026692682422	2.65801616612257	2.07740338608884e-15	miRanda	-0.105257516400941	0.00126797400951558		NA	NA	NA
hsa-miR-26a-5p	LEF1	-0.963792031426845	1.83360999387345e-22	2.65801616612257	2.07740338608884e-15	miRNATAP	-0.92158550768103	1.12073884009285e-08		NA	NA	NA
hsa-miR-26b-5p	LEF1	-1.10804856399744	4.14176110314282e-22	2.65801616612257	2.07740338608884e-15	miRNATAP	-0.884181051978605	1.54988692872715e-10	24785257	miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression		colon cancer
hsa-miR-3065-3p	LEF1	-1.04244468016704	4.60743424372577e-05	2.65801616612257	2.07740338608884e-15	miRNATAP	-0.274446867079685	2.50754901313177e-05		NA	NA	NA
hsa-miR-326	LEF1	-1.881935132554	1.68087316863775e-21	2.65801616612257	2.07740338608884e-15	miRanda	-0.385522349171234	2.19966753424773e-06		NA	NA	NA
hsa-miR-33a-3p	LEF1	-0.683025859637737	1.01106097756419e-05	2.65801616612257	2.07740338608884e-15	miRNATAP	-0.438284453346108	5.04525548190065e-05		NA	NA	NA
hsa-miR-455-5p	LEF1	-0.270546034117157	0.0581320703577731	2.65801616612257	2.07740338608884e-15	miRanda	-0.352774280915771	0.00297563964985378		NA	NA	NA
hsa-miR-590-3p	LEF1	-0.473167498047808	1.76652934637227e-05	2.65801616612257	2.07740338608884e-15	PITA;miRanda;mirMAP	-0.434383824253157	0.00459273011390873		NA	NA	NA
hsa-miR-7-1-3p	LEF1	-0.569105143287799	1.85297665041424e-05	2.65801616612257	2.07740338608884e-15	mirMAP	-0.451164571544049	0.000354486807433584		NA	NA	NA
hsa-miR-193a-3p	LIMS1	-0.117675551589896	0.309391958208578	-0.53231394759922	0.0185999713916091	MirTarget;miRanda	-0.26614257273691	0.00564703380071917		NA	NA	NA
hsa-miR-30d-5p	LIMS1	0.718283816348023	2.47422074061352e-08	-0.53231394759922	0.0185999713916091	MirTarget	-0.228396109947049	0.00701575739091265		NA	NA	NA
hsa-miR-192-5p	LOXL2	-0.50188499512787	0.00344713341196035	1.63969538101948	3.81782645914369e-28	miRNAWalker2_validate	-0.406183915121298	4.54599624471813e-21		NA	NA	NA
hsa-miR-28-5p	LOXL2	-0.430964830599964	2.67367257252925e-06	1.63969538101948	3.81782645914369e-28	miRanda	-0.414203048273971	8.20137540975636e-07		NA	NA	NA
hsa-miR-455-5p	LOXL3	-0.270546034117157	0.0581320703577731	0.0107326013149585	0.946699725545573	miRanda	-0.24694363207728	5.66890566118432e-06		NA	NA	NA
hsa-miR-101-3p	NOTCH1	-1.48176407980989	3.98950707385704e-31	-0.0333826274090256	0.795560724559869	MirTarget	-0.125967613612003	0.00574754801726533		NA	NA	NA
hsa-miR-34a-5p	NOTCH1	1.03694231790865	5.74864019540594e-14	-0.0333826274090256	0.795560724559869	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.239301431096606	3.83055699888448e-08	22438124;23140286;24349627;24565525;25783790;20351093;27082152;23642368;22347519;23430952;23902763;21743299;22992310;23145211;25623761;23085450	Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells; In our study using miRNA microarray we observed that downregulation of the Notch-1 pathway by delta-tocotrienol correlated with upregulation of miR-34a in nonsmall cell lung cancer cells NSCLC;We found that Re-expression forced expression of miR-34a inhibits cell growth and induces apoptosis with concomitant down-regulation of Notch-1 signaling pathway one of the target of miR-34a; Moreover treatment of PC cells with a natural compound genistein led to the up-regulation of miR-34a resulting in the down-regulation of Notch-1 which was correlated with inhibition of cell growth and induction of apoptosis;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed reexpression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;In addition intracellular restoration of miR-34a inhibited breast cancer cell migration via targeting Notch-1 signaling;MicroRNA 34a suppresses the breast cancer stem cell like characteristics by downregulating Notch1 pathway; In this study we verified that miR-34a directly and functionally targeted Notch1 in MCF-7 cells; We reported that miR-34a negatively regulated cell proliferation migration and invasion and breast cancer stem cell propagation by downregulating Notch1; The expression of miR-34a was negatively correlated with tumor stages metastasis and Notch1 expression in breast cancer tissues; Furthermore overexpression of miR-34a increased chemosensitivity of breast cancer cells to paclitaxel PTX by downregulating the Notch1 pathway; Taken together our results indicate that miR-34a inhibited breast cancer stemness and increased the chemosensitivity to PTX partially by downregulating the Notch1 pathway suggesting that miR-34a/Notch1 play an important role in regulating breast cancer stem cells;MicroRNA 34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells; Computational miRNA target prediction suggested that Notch1 and Jagged1 were targets of miR-34a; By using functional assays miR-34a was demonstrated to bind to the 3' untranslated regions of Notch1 and Jagged1; Forced expression of miR-34a altered the expression of Notch1 and Jagged1 protein as well as Notch signaling as shown by the response of Hairy Enhancer of Split-1 protein to these treatments using western blot analysis;We showed that miR-34a as a tumor suppressor could separately reduce the stemness of BCSCs and activate the cytotoxic susceptibility of BCSCs to natural killer NK cells in vitro via down regulating the expression of Notch1 signaling molecules;Mechanistically miR-34a sequesters Notch1 mRNA to generate a sharp threshold response where a bimodal Notch signal specifies the choice between self-renewal and differentiation;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed re-expression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis;Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial mesenchymal transition EMT by miR 34a mediated suppression of Notch 1 expression in non small cell lung cancer cell lines; Indeed rhamnetin and cirsiliol increased the expression of tumor-suppressive microRNA miR-34a in a p53-dependent manner leading to inhibition of Notch-1 expression;MicroRNA 34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme; Also we identified notch1 as a direct target gene of miR-34a; Knockdown of notch1 showed similar cellular functions as overexpression of miR-34a both in vitro and in vivo; Collectively our findings show that miR-34a is downregulated in GBM cells and inhibits GBM growth by targeting notch1;The re-expression of miR-34 led to a marked reduction in the expression of its target gene Notch-1;Inactivation of AR and Notch 1 signaling by miR 34a attenuates prostate cancer aggressiveness; We found that over-expression of miR-34a led to reduced expression of AR PSA and Notch-1; These findings suggest that the loss of miR-34a is directly linked with up-regulation of AR and Notch-1 both of which are highly expressed in PCa and thus finding innovative approaches by which miR-34a expression could be up-regulated will have a huge impact on the treatment of PCa especially for the treatment of mCRPC;miR 34a may regulate sensitivity of breast cancer cells to adriamycin via targeting Notch1; To explore the influence of miR-34a on Notch1 expression in breast cancer cells and to explore the role of miR-34a in the sensitivity of breast cancer cells to Adriamycin ADR; The expression levels of Notch1 mRNA and protein in MCF-7/ADR cells transfected with miR-34a mimics were significantly up-regulated; On the contrary the expressions of Notch1 mRNA and protein in MCF-7 cells transfected with miR-34a inhibitor were down-regulated; miR-34a negatively regulates the expression of Notch1 at both mRNA and protein levels;MicroRNA 34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting Notch1; The association of miR-34a and Notch1 was analyzed by dual-luciferase reporter assay and Notch1-siRNA technology; Real-time PCR assay was performed to test the expression of miR-34a and Notch1 in 38 selective breast cancer tissue samples; MiR-34a mimic could inhibit the luciferase activity of the construct containing wild-type 3' UTR of Notch1 in MCF-7/ADR cells; Further there was an inverse association between Notch1 and miR-34a expression in breast cancer; Dysregulation of miR-34a plays critical roles in the acquired ADR resistance of breast cancer at least in part via targeting Notch1	;;;cell migration;staging;metastasis;drug resistance;;differentiation;drug resistance;;;;;;;;drug resistance	lung squamous cell cancer;pancreatic cancer;prostate cancer;breast cancer;breast cancer;cervical and endocervical cancer;breast cancer;colon cancer;prostate cancer;sarcoma;lung squamous cell cancer;glioblastoma;colon cancer;prostate cancer;breast cancer;breast cancer
hsa-miR-576-5p	RBPJ	-0.377452008285847	0.00470735657343984	0.0751185265478251	0.474038384860477	mirMAP	-0.160144563271589	2.45790161889113e-05		NA	NA	NA
hsa-miR-616-5p	RBPJ	0.150569904638223	0.402836556304524	0.0751185265478251	0.474038384860477	MirTarget	-0.13577621610522	1.44489090682626e-06		NA	NA	NA
hsa-miR-664a-3p	RBPJ	0.485807855553031	0.000732553249798598	0.0751185265478251	0.474038384860477	mirMAP	-0.153572662989111	1.21488994120983e-05		NA	NA	NA
hsa-miR-204-5p	SNAI1	-0.537962150012103	0.0330895493358849	-1.12154757133066	1.27086429254762e-06	miRNAWalker2_validate	-0.169039964006828	0.000174942337299583	26729198	miR 204 regulates the EMT by targeting snai1 to suppress the invasion and migration of gastric cancer; By building the epithelial-mesenchymal transition EMT model in vitro through the addition of transforming growth factor beta 1 TGF-β1 expressions of miR-204 and snai1 in the EMT model together with their respective effects on EMT were evaluated; The over-expression of miR-204 or downregulation of snai1 could significantly inhibit the metastasis and invasion of GC cells both in vitro and in vivo; The upregulated miR-204 expression or inhibited snai1 expression could suppress the EMT process in EMT in vitro models; Our study provided evidence that miR-204 may suppress the metastasis and invasion of GC cells through the regulation of the EMT process by targeting snai1	metastasis	gastric cancer
hsa-miR-148b-3p	SNAI2	0.266862251671911	0.00185271302045935	0.384447886331124	0.102927984369101	miRNAWalker2_validate	-0.544029940642456	5.49522288288826e-05		NA	NA	NA
hsa-miR-181a-5p	SNAI2	0.250113435902954	0.0551933249319293	0.384447886331124	0.102927984369101	miRNAWalker2_validate	-0.261350612158367	0.00311299103180595		NA	NA	NA
hsa-miR-182-5p	SNAI2	1.96601340710222	4.39326175603633e-09	0.384447886331124	0.102927984369101	miRNAWalker2_validate;miRNATAP	-0.103835953273872	0.00197162374541916		NA	NA	NA
hsa-miR-200b-3p	SNAI2	-1.29335788099229	0.000268623234305059	0.384447886331124	0.102927984369101	TargetScan	-0.113933336744523	0.000370832757095312		NA	NA	NA
hsa-miR-200c-3p	SNAI2	-0.104675615392797	0.716957669484981	0.384447886331124	0.102927984369101	miRNATAP	-0.13296318092996	0.000812112160068585		NA	NA	NA
hsa-miR-320a	SNAI2	0.325285936317332	0.0221415065838824	0.384447886331124	0.102927984369101	miRanda	-0.214409102466517	0.00813189487988791		NA	NA	NA
hsa-miR-320b	SNAI2	0.0919652022571331	0.607981643616945	0.384447886331124	0.102927984369101	miRanda	-0.202087227587785	0.00173449253044878		NA	NA	NA
hsa-miR-330-3p	SNAI2	-0.332364259424489	0.0316051913061459	0.384447886331124	0.102927984369101	PITA	-0.196504661120588	0.00986696206545639		NA	NA	NA
hsa-miR-335-3p	SNAI2	-0.275199247483111	0.106629165248783	0.384447886331124	0.102927984369101	mirMAP	-0.217340446715799	0.00125313566599525		NA	NA	NA
hsa-miR-375	SNAI2	-1.93190458972328	4.28108492522e-06	0.384447886331124	0.102927984369101	miRanda	-0.209046657886176	1.12811819223104e-15		NA	NA	NA
hsa-miR-429	SNAI2	-1.40262535827285	6.93982219171912e-05	0.384447886331124	0.102927984369101	PITA;miRanda;miRNATAP	-0.124379059709461	0.000134132733571897		NA	NA	NA
hsa-miR-101-3p	SOX9	-1.48176407980989	3.98950707385704e-31	0.456898781063352	0.178110113816873	miRNAWalker2_validate;miRNATAP	-0.924442976530542	2.21450129261226e-15	23178713	Ectopic expression of miR-101 significantly inhibited HCC cell proliferation and tumorigenicity by targeting SOX9; Therefore miR-101 may suppress HCC tumor progression by down-regulating SOX9	progression	liver cancer
hsa-miR-30e-5p	SOX9	-0.627815042856657	3.02205690184908e-10	0.456898781063352	0.178110113816873	MirTarget	-0.794789900236748	9.82298473299795e-07		NA	NA	NA
hsa-miR-616-5p	SOX9	0.150569904638223	0.402836556304524	0.456898781063352	0.178110113816873	mirMAP;miRNATAP	-0.3420877500251	0.000199955576341579		NA	NA	NA
hsa-miR-139-5p	TGFB1	-2.11299531796557	8.16407076415038e-28	0.0791820105139553	0.6886056388594	miRanda	-0.165335310650966	0.000359864512900183		NA	NA	NA
hsa-miR-101-5p	TGFB2	-1.0634649894055	4.39116719827902e-16	0.529934214584709	0.036730862150581	mirMAP	-0.351880994764185	0.000113322446416492		NA	NA	NA
hsa-miR-107	TGFB2	0.241662461253461	0.0170788899505389	0.529934214584709	0.036730862150581	miRanda	-0.614314042069378	4.68765266846655e-07		NA	NA	NA
hsa-miR-148a-3p	TGFB2	-0.748702855596996	3.93313343865641e-07	0.529934214584709	0.036730862150581	MirTarget;miRNATAP	-0.661431979951743	1.43220896593668e-16		NA	NA	NA
hsa-miR-193a-3p	TGFB2	-0.117675551589896	0.309391958208578	0.529934214584709	0.036730862150581	MirTarget;miRanda;miRNATAP	-0.366329573810208	0.000659116520736421		NA	NA	NA
hsa-miR-193b-3p	TGFB2	-0.166697207281748	0.272022543069482	0.529934214584709	0.036730862150581	MirTarget;miRNATAP	-0.318957683478265	9.08737208626492e-05		NA	NA	NA
hsa-miR-33a-3p	TGFB2	-0.683025859637737	1.01106097756419e-05	0.529934214584709	0.036730862150581	MirTarget;mirMAP	-0.292910263006269	0.00021856118592367		NA	NA	NA
hsa-miR-362-3p	TGFB2	0.814007335895913	2.00108618836568e-09	0.529934214584709	0.036730862150581	miRanda	-0.235702914624554	0.00870288726391307		NA	NA	NA
hsa-miR-548b-3p	TGFB2	-0.0203576084717134	0.930819503166956	0.529934214584709	0.036730862150581	MirTarget	-0.251413034966269	2.19240613879876e-06		NA	NA	NA
hsa-miR-616-5p	TGFB2	0.150569904638223	0.402836556304524	0.529934214584709	0.036730862150581	mirMAP	-0.373291858655729	4.43049125036333e-08		NA	NA	NA
hsa-miR-618	TGFB2	0.13539895350352	0.517145913114103	0.529934214584709	0.036730862150581	MirTarget;miRNATAP	-0.323812991792447	9.41184108923406e-08		NA	NA	NA
hsa-let-7d-5p	TGFBR3	0.0503292020123807	0.702580311853671	-1.53475612080717	2.32211754233392e-15	MirTarget	-0.196855178961592	0.0084014005097078		NA	NA	NA
hsa-miR-103a-3p	TGFBR3	0.765568928457606	3.05497476509383e-12	-1.53475612080717	2.32211754233392e-15	MirTarget;miRNATAP	-0.516178135225821	1.8918636364374e-09		NA	NA	NA
hsa-miR-181a-5p	TGFBR3	0.250113435902954	0.0551933249319293	-1.53475612080717	2.32211754233392e-15	miRNAWalker2_validate;mirMAP;miRNATAP	-0.389031034293981	1.71466140133219e-07		NA	NA	NA
hsa-miR-181b-5p	TGFBR3	0.488256489401108	0.00105321129419701	-1.53475612080717	2.32211754233392e-15	mirMAP	-0.467119604365662	2.30736536364399e-13		NA	NA	NA
hsa-miR-181c-5p	TGFBR3	-0.00639394152050299	0.969127212255928	-1.53475612080717	2.32211754233392e-15	mirMAP;miRNATAP	-0.216998335317529	0.000246546877454723		NA	NA	NA
hsa-miR-182-5p	TGFBR3	1.96601340710222	4.39326175603633e-09	-1.53475612080717	2.32211754233392e-15	miRNATAP	-0.183612681218707	5.45847960443815e-11		NA	NA	NA
hsa-miR-18a-5p	TGFBR3	0.918028187958706	1.90229510425322e-05	-1.53475612080717	2.32211754233392e-15	MirTarget	-0.355232234366897	3.59550252157977e-16		NA	NA	NA
hsa-miR-21-5p	TGFBR3	1.51084295924322	1.54551622173259e-34	-1.53475612080717	2.32211754233392e-15	miRNAWalker2_validate	-0.700530304569563	4.67202507056358e-24		NA	NA	NA
hsa-miR-222-5p	TGFBR3	0.125716360553359	0.487423909991138	-1.53475612080717	2.32211754233392e-15	MirTarget	-0.326222351264924	9.58868656812027e-10		NA	NA	NA
hsa-miR-30d-5p	TGFBR3	0.718283816348023	2.47422074061352e-08	-1.53475612080717	2.32211754233392e-15	mirMAP	-0.341148711785332	4.54804473299737e-06		NA	NA	NA
hsa-miR-335-3p	TGFBR3	-0.275199247483111	0.106629165248783	-1.53475612080717	2.32211754233392e-15	mirMAP	-0.159138659572769	0.0055865810210199		NA	NA	NA
hsa-miR-338-3p	TGFBR3	0.543135607704581	0.00461167747143826	-1.53475612080717	2.32211754233392e-15	miRanda	-0.27955763129368	2.51562122970982e-08		NA	NA	NA
hsa-miR-339-5p	TGFBR3	0.280589919878422	0.0355660282647215	-1.53475612080717	2.32211754233392e-15	miRanda	-0.331241307788205	5.60177000922454e-06		NA	NA	NA
hsa-miR-423-5p	TGFBR3	0.698807775906485	1.02195196334612e-11	-1.53475612080717	2.32211754233392e-15	MirTarget	-0.36733348375029	8.14314564275236e-05		NA	NA	NA
hsa-miR-429	TGFBR3	-1.40262535827285	6.93982219171912e-05	-1.53475612080717	2.32211754233392e-15	miRanda	-0.126701063796612	4.47504894450001e-06		NA	NA	NA
hsa-miR-501-3p	TGFBR3	0.999540908940094	2.77358485581974e-11	-1.53475612080717	2.32211754233392e-15	TargetScan;miRNATAP	-0.387404581581371	6.00332430720371e-10		NA	NA	NA
hsa-miR-589-3p	TGFBR3	1.16846704028095	5.88525574424201e-11	-1.53475612080717	2.32211754233392e-15	MirTarget	-0.333449671175673	5.53850221641506e-10		NA	NA	NA
hsa-let-7b-5p	TRIM28	-0.959013717270803	5.95127281258643e-11	0.651853250493276	7.91407664709318e-12	miRNAWalker2_validate	-0.164812886203474	1.52104733143263e-07		NA	NA	NA
hsa-miR-193b-3p	TRIM28	-0.166697207281748	0.272022543069482	0.651853250493276	7.91407664709318e-12	miRNAWalker2_validate	-0.101430079847165	0.00122598859877156		NA	NA	NA
hsa-miR-30a-5p	TRIM28	-0.626257932887855	0.000108198196973765	0.651853250493276	7.91407664709318e-12	miRNAWalker2_validate	-0.140778241116591	1.15170055889899e-06		NA	NA	NA
hsa-miR-505-3p	TRIM28	-1.20027021591555	1.27927500175937e-13	0.651853250493276	7.91407664709318e-12	miRNAWalker2_validate	-0.136336657327203	1.36974885375606e-06		NA	NA	NA
hsa-miR-505-5p	TRIM28	-0.768282569967001	1.14662846595407e-05	0.651853250493276	7.91407664709318e-12	miRNAWalker2_validate	-0.114299536621946	1.91055847307726e-05		NA	NA	NA
hsa-miR-542-3p	TRIM28	-1.31351015149842	3.64642423288576e-22	0.651853250493276	7.91407664709318e-12	miRanda	-0.135307651570585	4.48321012688587e-05		NA	NA	NA
hsa-miR-107	WNT4	0.241662461253461	0.0170788899505389	-0.395843982979098	0.363792495355894	PITA;miRNATAP	-1.20015521254906	8.09058681955679e-09		NA	NA	NA
hsa-miR-375	WNT5A	-1.93190458972328	4.28108492522e-06	-0.379867591757487	0.265970692489084	miRNATAP	-0.114882013104506	0.00325292733019044		NA	NA	NA