miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-15b-5p AATK 0.251826642099145 0.790709218602499 0.00366137231187924 0.992434238880678 MirTarget -0.215788921370799 0.0443328290903608 NA NA NA hsa-miR-107 ABCA6 -0.289737369453023 0.769655185893943 -0.0113025832353411 0.980222515728787 miRanda -0.386206815721491 0.00470843933313109 NA NA NA hsa-miR-183-5p ABCA8 -0.0462269171194745 0.969489414828393 0.549386931123507 0.320984755917658 MirTarget -0.218916153052262 0.0201973478901607 NA NA NA hsa-miR-192-5p ABCA8 -0.00281508349767456 0.99638352116085 0.549386931123507 0.320984755917658 miRNAWalker2_validate -0.441469701134679 2.0322690279922e-05 NA NA NA hsa-miR-361-5p ABCA8 -0.278147578656315 0.728553069590798 0.549386931123507 0.320984755917658 miRanda -0.717077013585261 0.000863061554708227 NA NA NA hsa-miR-375 ABCA8 -0.989394125724925 0.312728638150002 0.549386931123507 0.320984755917658 miRanda -0.146638375219069 0.0226122496898926 NA NA NA hsa-miR-15b-5p ABCB5 0.251826642099145 0.790709218602499 1.02537526594708 0.0820602917286101 MirTarget -0.37278979036989 0.0246150474959498 NA NA NA hsa-miR-146b-5p ABCG2 0.0340352805627226 0.964565988329585 -0.34956766507563 0.220339464116446 miRanda -0.10100138213818 0.0450757188145052 NA NA NA hsa-miR-199b-5p ABCG2 0.415198317247236 0.324258779965011 -0.34956766507563 0.220339464116446 miRanda -0.140061154033689 0.000716482574653608 NA NA NA hsa-miR-107 ABHD12B -0.289737369453023 0.769655185893943 0.0926809214178475 0.832547753058811 miRanda -0.367715509249656 0.0014767166347221 NA NA NA hsa-miR-107 ABHD13 -0.289737369453023 0.769655185893943 0.0880398765941282 0.821843894057664 MirTarget;miRanda -0.10505739292321 0.00367860711833696 NA NA NA hsa-miR-125a-5p ABHD6 -0.00666761469427968 0.994891296705929 0.10261138835132 0.725611603015467 MirTarget;PITA;miRanda;miRNATAP -0.162203533047904 0.0134670453879015 NA NA NA hsa-miR-21-3p ABI2 0.129101420041684 0.877913267462969 -0.126747293103636 0.821722578743484 MirTarget -0.125755059128973 4.21879797814217e-07 NA NA NA hsa-miR-23a-3p ABI2 0.174045248211037 0.865717934161724 -0.126747293103636 0.821722578743484 mirMAP -0.103893149041847 0.00624965085581429 NA NA NA hsa-miR-342-3p ABI2 -0.233020179388453 0.739959578456401 -0.126747293103636 0.821722578743484 miRanda -0.147729885579667 2.86420534196778e-05 NA NA NA hsa-miR-107 ABR -0.289737369453023 0.769655185893943 -0.461179591458234 0.367742955301533 miRanda -0.130862418463922 0.0407371616025406 NA NA NA hsa-miR-222-3p ACACA -0.233673471709747 0.726651775432807 -0.229138868482066 0.667346204896078 miRNAWalker2_validate -0.101095961777545 0.00385851473044844 NA NA NA hsa-miR-107 ACO1 -0.289737369453023 0.769655185893943 0.0109921839687521 0.981996243736166 miRanda -0.146345422966013 0.00127334582369869 NA NA NA hsa-miR-107 ACTG2 -0.289737369453023 0.769655185893943 0.61629905264253 0.281774547239621 miRanda -0.328518685350516 0.0255337304121472 NA NA NA hsa-miR-129-5p ACTG2 0.417083435812871 0.454236109516901 0.61629905264253 0.281774547239621 miRanda -0.181213124288817 0.0168645102131807 NA NA NA hsa-miR-125a-5p ACTL6A -0.00666761469427968 0.994891296705929 -0.0587543925023439 0.917117811906533 miRanda -0.174101127487207 0.00236879155482749 NA NA NA hsa-miR-140-3p ACVR2B -0.105651799466207 0.9077781740714 -0.143270074789807 0.740318276454807 miRNAWalker2_validate;PITA;miRNATAP -0.11952888908484 0.0243752084439025 NA NA NA hsa-miR-15b-5p ACVR2B 0.251826642099145 0.790709218602499 -0.143270074789807 0.740318276454807 miRNATAP -0.280375845269428 1.92811542397483e-06 NA NA NA hsa-miR-221-3p ADAM11 -0.261179092929062 0.744019631321393 -0.511569387683909 0.144437249240675 miRNATAP -0.301622531013277 0.000224395710627432 NA NA NA hsa-miR-222-3p ADAM11 -0.233673471709747 0.726651775432807 -0.511569387683909 0.144437249240675 miRNATAP -0.258750021160582 0.0014686298308555 NA NA NA hsa-miR-221-3p ADAM22 -0.261179092929062 0.744019631321393 0.358744675636719 0.387333598458432 MirTarget;miRNATAP -0.360321816594511 0.000151059946974442 NA NA NA hsa-miR-222-3p ADAM22 -0.233673471709747 0.726651775432807 0.358744675636719 0.387333598458432 MirTarget;miRNATAP -0.335129307180315 0.000389898745507334 NA NA NA hsa-miR-197-3p ADAMTS1 0.0240027695773914 0.981971058073739 -0.258004050803228 0.696089741103685 miRNATAP -0.20422345199331 0.0453445142416977 NA NA NA hsa-miR-27a-3p ADAMTS10 0.309634509674364 0.703724209648479 -0.0142132801593049 0.969873234209021 MirTarget;miRNATAP -0.207026857203541 0.0131788380330715 NA NA NA hsa-miR-15b-5p ADAMTS18 0.251826642099145 0.790709218602499 -0.280751107758864 0.549022782469007 miRNATAP -0.49754983571533 0.000497768228941499 NA NA NA hsa-miR-107 ADAMTS19 -0.289737369453023 0.769655185893943 -0.26799726419209 0.711866073448671 miRanda -0.432900856401642 0.0193248194280713 NA NA NA hsa-miR-148a-3p ADAMTS19 -0.324144803192141 0.746264759480212 -0.26799726419209 0.711866073448671 MirTarget -0.301249873354563 0.0405932480369829 NA NA NA hsa-miR-15b-5p ADAMTS5 0.251826642099145 0.790709218602499 -0.00185057499031682 0.996540799356434 miRNATAP -0.324491334640395 0.00415047431381499 NA NA NA hsa-miR-221-3p ADAMTS6 -0.261179092929062 0.744019631321393 0.125580301241154 0.724846911503146 MirTarget -0.179907047847241 0.0298499172641118 NA NA NA hsa-miR-222-3p ADAMTS6 -0.233673471709747 0.726651775432807 0.125580301241154 0.724846911503146 MirTarget -0.203949208172817 0.0129570775522397 NA NA NA hsa-miR-107 ADAMTSL3 -0.289737369453023 0.769655185893943 -0.0396425098915616 0.933421479798619 MirTarget;PITA;miRanda;miRNATAP -0.287574268081256 0.0338602296743775 NA NA NA hsa-miR-150-5p ADCY1 -0.00683324482969283 0.994067057151257 -0.136166970563614 0.729350109785873 mirMAP -0.199137825435333 0.000171034709537618 NA NA NA hsa-miR-128-3p ADCY2 -0.0364518492233463 0.95841670253784 -0.1605716568309 0.819369351249095 MirTarget -0.767567002290905 0.000342417105382799 NA NA NA hsa-miR-148a-3p ADCY2 -0.324144803192141 0.746264759480212 -0.1605716568309 0.819369351249095 MirTarget;miRNATAP -0.466733878701922 0.00441717237048026 NA NA NA hsa-miR-107 ADCYAP1 -0.289737369453023 0.769655185893943 0.668825765815771 0.312073170348457 MirTarget;PITA;miRanda;miRNATAP -0.63494964361952 0.000477710411393023 NA NA NA hsa-miR-150-5p ADCYAP1R1 -0.00683324482969283 0.994067057151257 0.794247395527034 0.273015470971313 mirMAP -0.495472569014078 9.79486161128313e-07 NA NA NA hsa-miR-148a-5p ADH1B -0.160202546137977 0.744679670526904 1.67887778030661 0.0430030828328342 MirTarget -0.378295759510125 0.0369867520956969 NA NA NA hsa-miR-186-5p ADH1B -0.246324984406451 0.701310703524093 1.67887778030661 0.0430030828328342 mirMAP -0.598594230973799 0.0240003956774899 NA NA NA hsa-miR-200b-5p ADH1B -0.216289118354351 0.75028934269524 1.67887778030661 0.0430030828328342 mirMAP -0.448475433001274 0.00850317439609834 NA NA NA hsa-miR-429 ADH1B -0.596617415946644 0.128967410286089 1.67887778030661 0.0430030828328342 miRanda -0.553892235859212 0.000608504728351729 NA NA NA hsa-miR-500a-5p ADH1B -0.232217839578781 0.516569510502181 1.67887778030661 0.0430030828328342 mirMAP -0.354722407689575 0.0394096866315159 NA NA NA hsa-miR-501-5p ADH1B -0.277968789063541 0.510742720785555 1.67887778030661 0.0430030828328342 mirMAP -0.489453994348007 0.00262115348239945 NA NA NA hsa-miR-150-5p ADRA2B -0.00683324482969283 0.994067057151257 -0.510539705893778 0.21803612446203 mirMAP -0.195728484906417 0.000727460739526366 NA NA NA hsa-miR-326 AGBL2 0.307641210889423 0.653580115931293 -0.0688067695873052 0.85032606257171 miRanda -0.225890714910306 0.000606814599374522 NA NA NA hsa-miR-330-5p AGBL2 -0.152605584680815 0.787259112745893 -0.0688067695873052 0.85032606257171 miRanda -0.216788480237146 0.0224835856309986 NA NA NA hsa-miR-22-3p AGBL5 0.0468440219945929 0.967778504781139 0.0905910037581368 0.874374000695286 MirTarget;miRNATAP -0.161406284451993 5.00904836697278e-06 NA NA NA hsa-miR-15b-5p AGPAT4 0.251826642099145 0.790709218602499 -0.101365308772345 0.783505840899964 mirMAP -0.309400139597459 1.90252662574046e-05 NA NA NA hsa-miR-15b-5p AHCYL2 0.251826642099145 0.790709218602499 -0.00481746947345574 0.991118801570005 miRNATAP -0.109356481116602 0.0128982805607684 NA NA NA hsa-miR-15b-5p AHRR 0.251826642099145 0.790709218602499 -0.449564965936622 0.157514489593808 mirMAP -0.233680084689247 0.010856246236865 NA NA NA hsa-miR-25-3p AIM1 0.0681841609869576 0.955267320175687 0.0663167769488178 0.885476940793343 miRNAWalker2_validate -0.216609829781258 0.0182565899196253 NA NA NA hsa-miR-335-3p AK1 0.0738544228922926 0.89349398283313 0.414763690083865 0.379008839124202 mirMAP -0.129327447045231 0.000465264448330174 NA NA NA hsa-miR-423-5p AK1 -0.314923545892784 0.658894400879422 0.414763690083865 0.379008839124202 miRNATAP -0.139051741103896 0.0345187114192648 NA NA NA hsa-miR-128-3p AKR7A2 -0.0364518492233463 0.95841670253784 0.393407728380821 0.446115703498878 MirTarget -0.117961139854515 0.00474783426997669 NA NA NA hsa-miR-107 AKT3 -0.289737369453023 0.769655185893943 0.0947859458741349 0.829894131767605 PITA;miRanda -0.286283898354911 0.00414419911481135 NA NA NA hsa-miR-335-3p ALCAM 0.0738544228922926 0.89349398283313 -0.646962010556941 0.277379395289716 mirMAP -0.186931447638671 0.000882811712544149 NA NA NA hsa-miR-338-3p ALCAM -0.107178830331044 0.818042702366464 -0.646962010556941 0.277379395289716 miRanda -0.146200964754244 0.00344826270538537 NA NA NA hsa-miR-9-5p ALCAM 0.029299723902132 0.964227616086639 -0.646962010556941 0.277379395289716 MirTarget;miRNATAP -0.1315361223657 0.000753122591462113 NA NA NA hsa-miR-107 ALDH1A2 -0.289737369453023 0.769655185893943 1.22455153716573 0.0697715528600013 miRanda -0.401183192242596 0.0379395447268054 NA NA NA hsa-miR-27a-3p ALDH9A1 0.309634509674364 0.703724209648479 0.0462176196486039 0.93051000062085 miRNAWalker2_validate -0.14460389560942 5.3425064059128e-06 NA NA NA hsa-miR-100-5p ALG3 0.0542447471759004 0.961097766133859 0.151929935454269 0.806047158411976 miRNAWalker2_validate -0.101906407714107 0.000115499124875199 NA NA NA hsa-miR-150-5p ALS2CR12 -0.00683324482969283 0.994067057151257 -0.55593093845038 0.290161211682283 MirTarget -0.241244088766436 0.00019010954289654 NA NA NA hsa-miR-107 AMFR -0.289737369453023 0.769655185893943 0.0343461951799338 0.953649502838488 miRanda -0.180318684122681 6.61920468473298e-06 NA NA NA hsa-miR-150-5p AMIGO1 -0.00683324482969283 0.994067057151257 -0.262423194855389 0.361851216964202 mirMAP -0.102731209444192 0.000229523913885984 NA NA NA hsa-miR-183-5p AMIGO2 -0.0462269171194745 0.969489414828393 0.291579596732606 0.503937622353518 MirTarget -0.191403864281221 0.000255299338724457 NA NA NA hsa-miR-598-3p AMIGO2 -0.920463702622238 0.0470962134022858 0.291579596732606 0.503937622353518 MirTarget -0.178188633081552 0.000496980619408017 NA NA NA hsa-miR-222-3p AMMECR1 -0.233673471709747 0.726651775432807 -0.136739834032924 0.774279484223647 miRNATAP -0.112348571614298 0.0102118940525544 NA NA NA hsa-miR-381-3p AMN1 0.269633663970002 0.562625029053898 0.129493191446234 0.762902185645286 MirTarget -0.149656746195051 0.000724117481164779 NA NA NA hsa-miR-27a-3p AMOTL1 0.309634509674364 0.703724209648479 0.662499087105108 0.214709397666152 mirMAP -0.151114765080162 0.021997223760726 NA NA NA hsa-miR-27a-3p ANK1 0.309634509674364 0.703724209648479 -0.597982888297342 0.210086729938373 miRNATAP -0.372598432904112 0.00264730041255033 NA NA NA hsa-miR-15b-5p ANK2 0.251826642099145 0.790709218602499 0.0796094147748652 0.862500758786231 MirTarget;miRNATAP -0.347658568230006 0.0036170249937798 NA NA NA hsa-miR-107 ANKMY2 -0.289737369453023 0.769655185893943 0.0689117540515474 0.853295413134394 miRanda -0.110727440117534 0.026750747511044 NA NA NA hsa-miR-505-3p ANKMY2 -0.101578624236243 0.868681779756913 0.0689117540515474 0.853295413134394 MirTarget -0.122265485794142 0.0159454481897359 NA NA NA hsa-miR-15b-5p ANKRD13B 0.251826642099145 0.790709218602499 0.023221446731279 0.948850145859197 miRNATAP -0.253675622711755 0.0011873292938647 NA NA NA hsa-miR-15b-5p ANKRD29 0.251826642099145 0.790709218602499 0.37785994845105 0.256732154845484 MirTarget -0.264268896768679 0.00946800274707432 NA NA NA hsa-miR-15b-5p ANKRD46 0.251826642099145 0.790709218602499 0.120231891569142 0.775398222006662 MirTarget -0.171922877380229 0.000426997248521459 NA NA NA hsa-miR-221-3p ANKRD52 -0.261179092929062 0.744019631321393 -0.188527554564534 0.747302985770909 miRNATAP -0.123744650841191 0.000530022018567325 NA NA NA hsa-miR-222-3p ANKRD52 -0.233673471709747 0.726651775432807 -0.188527554564534 0.747302985770909 miRNATAP -0.149484195169689 2.22827511181798e-05 NA NA NA hsa-miR-15b-5p ANKS1A 0.251826642099145 0.790709218602499 -0.288207593143918 0.61184174008611 MirTarget -0.161960029303134 0.000689062916627648 NA NA NA hsa-miR-214-3p ANKS1B 0.0312810611346688 0.952640488671912 0.306308430699038 0.399381539749385 miRNATAP -0.188267561055325 0.000812367289406013 NA NA NA hsa-miR-148a-3p ANKS6 -0.324144803192141 0.746264759480212 -0.0343270562125761 0.944656633896678 mirMAP -0.101287197313922 0.00502691254522411 NA NA NA hsa-let-7b-5p ANP32E 0.396604576702067 0.783406687058469 -0.201564855550288 0.710770449917046 miRNAWalker2_validate -0.124933866331789 0.000245342486539563 NA NA NA hsa-miR-107 ANTXR1 -0.289737369453023 0.769655185893943 0.539759749710266 0.427966400884912 miRanda -0.197042409250225 0.0116039121102554 NA NA NA hsa-miR-660-5p ANTXR1 -0.561687438133488 0.138270972367544 0.539759749710266 0.427966400884912 mirMAP -0.1268376162704 0.00946355128761485 NA NA NA hsa-miR-125a-3p ANXA4 0.124026360619668 0.800539414590835 -0.108494365272303 0.855779413147392 miRanda -0.133547907962246 0.033544680416279 NA NA NA hsa-miR-10b-5p AOC3 -0.866656492462537 0.502462749031016 0.34985953231956 0.401121540349162 mirMAP -0.218591317733422 0.000133434212459047 NA NA NA hsa-miR-361-5p AOC3 -0.278147578656315 0.728553069590798 0.34985953231956 0.401121540349162 MirTarget;miRanda -0.309737283437197 0.0248150848024203 NA NA NA hsa-miR-107 AP1S2 -0.289737369453023 0.769655185893943 0.107772475792509 0.783519490150423 PITA;miRanda -0.107702642063547 0.0394079351219164 NA NA NA hsa-miR-107 AP2A1 -0.289737369453023 0.769655185893943 -0.0460627757933176 0.941573420555596 miRanda -0.147372943762635 2.03755696060255e-05 NA NA NA hsa-miR-15b-5p AP2A1 0.251826642099145 0.790709218602499 -0.0460627757933176 0.941573420555596 miRNATAP -0.10181870677062 0.00480543720392568 NA NA NA hsa-miR-107 APBA1 -0.289737369453023 0.769655185893943 -0.0110002112322585 0.975583597686264 miRNATAP -0.220468742792577 0.00205243103075801 NA NA NA hsa-miR-15b-5p APRT 0.251826642099145 0.790709218602499 0.409675703844303 0.479755897451844 miRNAWalker2_validate -0.124235287273668 0.0232959313644253 NA NA NA hsa-miR-15b-5p AQP11 0.251826642099145 0.790709218602499 -0.822604445158749 0.00192335564021062 MirTarget -0.408472204211149 5.51902247775802e-09 NA NA NA hsa-miR-27a-3p AQP11 0.309634509674364 0.703724209648479 -0.822604445158749 0.00192335564021062 MirTarget;miRNATAP -0.228548560767848 0.00014132829765964 NA NA NA hsa-miR-485-3p AQP9 0.260493747772693 0.658365017969425 0.295013110729641 0.584522503775687 MirTarget -0.153107492403681 0.032751614427227 NA NA NA hsa-miR-885-5p AQP9 -0.119561979753203 0.861296588445352 0.295013110729641 0.584522503775687 miRNATAP -0.118972011123551 0.0401035093842026 NA NA NA hsa-miR-130b-3p AR -0.246958204594817 0.524070870130445 0.00408360705556055 0.99406631963829 mirMAP;miRNATAP -0.373015990280623 0.000833404151228889 NA NA NA hsa-miR-130b-5p AR -0.318833907124358 0.508178803208229 0.00408360705556055 0.99406631963829 mirMAP -0.296469430051356 0.0145279620556277 NA NA NA hsa-miR-212-3p AR -0.118513342558296 0.740632149411935 0.00408360705556055 0.99406631963829 mirMAP -0.247682448916788 0.00866492789124181 26553749 Aberrant coexpression of AR and hnRNPH1 and downregulation of miR-212 were detected in prostate tumors and correlate with disease progression in AA men compared with CA men; Ectopic expression of miR-212 mimics downregulated hnRNPH1 transcripts which in turn reduced expression of AR and its splice variant AR-V7 or AR3 in prostate cancer cells progression prostate cancer hsa-miR-629-3p AR -0.455149050361454 0.209212127982437 0.00408360705556055 0.99406631963829 mirMAP -0.244387931390302 0.0144598479060736 NA NA NA hsa-miR-22-3p ARC 0.0468440219945929 0.967778504781139 -0.248282159806999 0.596661730587338 mirMAP -0.312350115041477 0.00365307407055968 NA NA NA hsa-miR-128-3p ARHGAP23 -0.0364518492233463 0.95841670253784 -0.185901102266786 0.770178384296621 MirTarget -0.207942764454724 0.00445832724214741 NA NA NA hsa-miR-107 ARHGAP24 -0.289737369453023 0.769655185893943 0.109467456393916 0.728338095797316 miRanda -0.177711069320301 0.0158684933284331 NA NA NA hsa-miR-98-5p ARHGAP28 -0.0484028619275874 0.910781316485549 0.322828502676271 0.377357982273618 miRNAWalker2_validate;MirTarget -0.217643323013662 0.000260775843566463 NA NA NA hsa-miR-148a-3p ARHGEF17 -0.324144803192141 0.746264759480212 -0.299486231342092 0.637742415254754 miRNATAP -0.107203361253192 0.00677035313093866 NA NA NA hsa-miR-15b-5p ARL2 0.251826642099145 0.790709218602499 0.0776760229588875 0.89101937265624 MirTarget;miRNATAP -0.162873273657352 0.00136764225009551 NA NA NA hsa-miR-374b-5p ARL4A -0.267096820650889 0.470048956816 0.0702156418088178 0.837429844199449 mirMAP -0.113169072813409 0.0130486891277058 NA NA NA hsa-miR-106a-5p ARL4C -0.820057689616516 0.0254490146664247 0.568493583036035 0.411997795039638 MirTarget;miRNATAP -0.108129920421499 0.0250205058827398 NA NA NA hsa-miR-192-5p ARL4C -0.00281508349767456 0.99638352116085 0.568493583036035 0.411997795039638 miRNAWalker2_validate -0.10026084328791 0.0449136728701385 NA NA NA hsa-miR-30c-5p ARL4C -0.183013966936985 0.833177718550926 0.568493583036035 0.411997795039638 miRNATAP -0.188394854895366 0.016439610526203 NA NA NA hsa-miR-429 ARL4C -0.596617415946644 0.128967410286089 0.568493583036035 0.411997795039638 miRNATAP -0.112603304144515 0.0284983101727907 NA NA NA hsa-miR-9-5p ARL4C 0.029299723902132 0.964227616086639 0.568493583036035 0.411997795039638 miRNATAP -0.127090325446386 0.00023612385933552 NA NA NA hsa-miR-140-3p ARL6IP1 -0.105651799466207 0.9077781740714 -0.02412259371002 0.973302760751521 miRNATAP -0.179966253343358 5.66164190545632e-06 NA NA NA hsa-miR-139-5p ARMC2 -0.0625698939687087 0.914810329989088 -0.0307329009745307 0.898107518989922 MirTarget -0.105749726220102 0.0357340369497645 NA NA NA hsa-miR-15b-5p ARMC5 0.251826642099145 0.790709218602499 -0.112236617482046 0.767255579718848 mirMAP;miRNATAP -0.164293881874115 3.58825751446158e-05 NA NA NA hsa-miR-15b-5p ARVCF 0.251826642099145 0.790709218602499 -0.627255947319014 0.129396076778317 mirMAP -0.169677905939172 0.00576217525217427 NA NA NA hsa-miR-27a-3p ARX 0.309634509674364 0.703724209648479 -1.62932830189481 0.0701159942616033 miRNATAP -0.54787440440895 0.0190998030209078 NA NA NA hsa-miR-214-3p ASF1B 0.0312810611346688 0.952640488671912 0.0933143302197523 0.861811994940446 miRNAWalker2_validate -0.108376485311659 0.00626747076450623 NA NA NA hsa-miR-320c ASF1B 0.092255964601645 0.785539881268253 0.0933143302197523 0.861811994940446 miRanda -0.187191872812682 0.000789870740015894 NA NA NA hsa-let-7a-5p ASPM 0.0514604984725615 0.971564723582327 -0.12990980236152 0.763488381390582 miRNAWalker2_validate -0.142929061159684 0.0314810323629682 NA NA NA hsa-miR-101-3p ASPN -0.0149915187591869 0.981999725022451 0.846226931209991 0.129916579409706 MirTarget;miRNATAP -0.308357310371517 0.0301436641323092 NA NA NA hsa-miR-129-5p ASPN 0.417083435812871 0.454236109516901 0.846226931209991 0.129916579409706 miRanda -0.257220278546711 0.00224517934123789 NA NA NA hsa-miR-219a-1-3p ASPN -0.385733322151236 0.345512422463289 0.846226931209991 0.129916579409706 MirTarget -0.565388966495749 7.51401466356681e-06 NA NA NA hsa-miR-26a-5p ASPN 0.0483232931294246 0.955218190818435 0.846226931209991 0.129916579409706 MirTarget;miRNATAP -0.414388049184314 0.0212952860626387 NA NA NA hsa-miR-26b-5p ASPN 0.16143906971203 0.790777916193478 0.846226931209991 0.129916579409706 miRNAWalker2_validate;MirTarget;miRNATAP -0.370734212697907 0.0384224781483032 NA NA NA hsa-miR-429 ASPN -0.596617415946644 0.128967410286089 0.846226931209991 0.129916579409706 miRanda -0.318962195613844 0.00255905505663179 NA NA NA hsa-miR-1266-5p ASTN1 0.193428002960802 0.749720354543557 0.610239474789576 0.311296702343616 MirTarget -0.367546174957287 0.00674527528122836 NA NA NA hsa-miR-15a-5p ASTN1 -0.288312177100971 0.506274963146038 0.610239474789576 0.311296702343616 MirTarget -0.445296814223001 0.000262033804999833 NA NA NA hsa-miR-15b-5p ASTN1 0.251826642099145 0.790709218602499 0.610239474789576 0.311296702343616 MirTarget -0.363865904382073 0.0488073570409128 NA NA NA hsa-miR-16-5p ASTN1 -0.199225750365017 0.742834324195084 0.610239474789576 0.311296702343616 MirTarget -0.3731451605486 0.0141694258226729 NA NA NA hsa-miR-185-5p ASTN1 -0.646398728237327 0.117918763555657 0.610239474789576 0.311296702343616 MirTarget -0.466296287682077 0.000995851217070273 NA NA NA hsa-miR-200a-3p ASTN1 -0.801422367541981 0.147987649395985 0.610239474789576 0.311296702343616 MirTarget;miRNATAP -0.295573983484668 0.00879751016987736 NA NA NA hsa-miR-330-5p ASTN1 -0.152605584680815 0.787259112745893 0.610239474789576 0.311296702343616 MirTarget;miRNATAP -0.508908695616224 0.00105836217691194 NA NA NA hsa-miR-34a-5p ASTN1 -0.689845719362998 0.195745632660671 0.610239474789576 0.311296702343616 MirTarget -0.283091993543504 0.0337255213390501 NA NA NA hsa-miR-378a-5p ASTN1 -0.031968081769751 0.969717820343558 0.610239474789576 0.311296702343616 mirMAP -0.385334253627742 0.00161388439127873 NA NA NA hsa-miR-221-3p ASXL3 -0.261179092929062 0.744019631321393 0.0531685877968833 0.926389212317434 miRNAWalker2_validate -0.292075898899439 0.0237738593425286 NA NA NA hsa-miR-26a-5p ATAD2 0.0483232931294246 0.955218190818435 -0.142421251368696 0.79618744309237 MirTarget -0.266257711455336 1.7752086125776e-05 NA NA NA hsa-miR-15b-5p ATF7IP2 0.251826642099145 0.790709218602499 -0.188735079213755 0.589298029645364 miRNATAP -0.162303866181351 0.0144190195027338 NA NA NA hsa-miR-27a-3p ATOH7 0.309634509674364 0.703724209648479 -0.43820152686997 0.326498683837155 miRNATAP -0.394679098066391 8.81927357290049e-05 NA NA NA hsa-miR-107 ATP11B -0.289737369453023 0.769655185893943 0.0421567198214783 0.933451954251035 miRanda -0.176354525708427 7.8731601019155e-05 NA NA NA hsa-miR-150-5p ATP1A2 -0.00683324482969283 0.994067057151257 0.824377739915931 0.164520481874588 mirMAP -0.169746478174759 0.0455143549075697 NA NA NA hsa-miR-222-3p ATP7B -0.233673471709747 0.726651775432807 -0.100401305816089 0.821976592657238 miRNAWalker2_validate -0.22760035216187 0.000121088032025173 NA NA NA hsa-miR-27a-3p ATP7B 0.309634509674364 0.703724209648479 -0.100401305816089 0.821976592657238 miRNAWalker2_validate -0.173049851804704 0.00947000396782939 NA NA NA hsa-miR-15b-5p ATXN7L1 0.251826642099145 0.790709218602499 -0.0651660876457711 0.859842343416461 miRNATAP -0.140856531955061 0.0018771247650649 NA NA NA hsa-miR-15b-5p ATXN7L2 0.251826642099145 0.790709218602499 -0.305035140611444 0.359886811792949 MirTarget;miRNATAP -0.141190359130148 0.00644051685686942 NA NA NA hsa-miR-15b-5p ATXN7L3 0.251826642099145 0.790709218602499 -0.174452707723041 0.747958984952326 MirTarget;miRNATAP -0.122685507273605 0.000843787900588488 NA NA NA hsa-miR-15b-5p ATXN7L3B 0.251826642099145 0.790709218602499 0.0666914921274744 0.918757807569171 MirTarget -0.115873285630816 0.00587089894335372 NA NA NA hsa-let-7b-5p AURKA 0.396604576702067 0.783406687058469 -0.0408611054011212 0.932537429461157 miRNAWalker2_validate -0.176229078097588 0.000248397884481489 NA NA NA hsa-let-7b-5p AURKB 0.396604576702067 0.783406687058469 -0.411688029335926 0.337942043572023 miRNAWalker2_validate -0.254710687175986 1.71229653981201e-05 NA NA NA hsa-miR-125b-5p AURKB 0.0074438975183444 0.994154663318355 -0.411688029335926 0.337942043572023 miRNAWalker2_validate -0.262520245121995 9.23665133991472e-06 NA NA NA hsa-miR-363-3p B3GALT2 -0.186046567396088 0.728622856049059 0.0117321430184167 0.972005203378632 MirTarget -0.130765233716131 0.00446869125118555 NA NA NA hsa-miR-150-5p B4GALNT3 -0.00683324482969283 0.994067057151257 -0.475608423311214 0.312015782371036 mirMAP -0.237447049779657 6.77017124998706e-06 NA NA NA hsa-miR-27a-3p B4GALT3 0.309634509674364 0.703724209648479 0.0135684890033572 0.9792109656104 MirTarget;miRNATAP -0.157445564508993 1.62636254387801e-07 26987623 B4GALT3 up regulation by miR 27a contributes to the oncogenic activity in human cervical cancer cells; To explore the mechanism of dysregulation B4GALT3 was predicted to be a target of miR-27a; EGFP and pGL3-promoter reporter assay showed miR-27a binds to B4GALT3 3'UTR region but enhanced its expression; Furthermore shR-B4GALT3 counteracted the promotion of malignancies induced by miR-27a suggesting miR-27a upregulates B4GALT3 to enhance tumorigenic activities; Altogether our findings evidenced that B4GALT3 upregulated by miR-27a contributes to the tumorigenic activities by β1-integrin pathway and might provide potential biomarkers for cervical cancer cervical and endocervical cancer hsa-miR-148a-3p B4GALT5 -0.324144803192141 0.746264759480212 0.145239508552699 0.834143413923099 MirTarget;miRNATAP -0.12964456495679 8.77765207918221e-05 NA NA NA hsa-miR-148a-3p BACH2 -0.324144803192141 0.746264759480212 3.59502479421181e-05 0.999920470056508 MirTarget;miRNATAP -0.239371462369303 0.00257823554424586 NA NA NA hsa-miR-15b-5p BACH2 0.251826642099145 0.790709218602499 3.59502479421181e-05 0.999920470056508 MirTarget;miRNATAP -0.20528032019449 0.0483142505205604 NA NA NA hsa-miR-15b-5p BAMBI 0.251826642099145 0.790709218602499 0.0384048009127782 0.931373708163178 miRNAWalker2_validate -0.293993858550452 0.0208188403495997 NA NA NA hsa-miR-107 BASP1 -0.289737369453023 0.769655185893943 0.173681340396683 0.73895698730428 miRanda -0.252426727456206 0.00947977552048052 NA NA NA hsa-miR-186-5p BCAT1 -0.246324984406451 0.701310703524093 0.390729359005611 0.580202665211518 MirTarget -0.350213061688218 0.0193648522722065 NA NA NA hsa-miR-195-3p BCAT1 -0.156258661515859 0.711891893678154 0.390729359005611 0.580202665211518 mirMAP -0.241887975479121 0.0143150565502237 NA NA NA hsa-miR-23a-3p BCAT1 0.174045248211037 0.865717934161724 0.390729359005611 0.580202665211518 mirMAP -0.39565192802267 0.00528885042401156 NA NA NA hsa-miR-339-5p BCAT1 -0.121565674268033 0.81427862647099 0.390729359005611 0.580202665211518 miRanda -0.248504927444081 0.0437755868159548 NA NA NA hsa-miR-374b-5p BCAT1 -0.267096820650889 0.470048956816 0.390729359005611 0.580202665211518 mirMAP -0.229033808701623 0.0257255089703043 NA NA NA hsa-miR-26b-5p BCHE 0.16143906971203 0.790777916193478 2.00146328472132 0.00359342700504471 miRNAWalker2_validate -0.456348437351378 0.0438514612591072 NA NA NA hsa-miR-429 BCHE -0.596617415946644 0.128967410286089 2.00146328472132 0.00359342700504471 miRanda -0.496171886562869 0.000193817551023254 NA NA NA hsa-miR-15b-5p BCL2 0.251826642099145 0.790709218602499 0.000634771319967697 0.998709437687408 miRNAWalker2_validate;miRTarBase -0.224084718519069 0.00768379109864967 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-22-3p BCL9 0.0468440219945929 0.967778504781139 -0.0473050382855567 0.938907861608285 MirTarget;miRNATAP -0.131996543193398 0.000532954631801289 NA NA NA hsa-miR-98-5p BEGAIN -0.0484028619275874 0.910781316485549 -0.060157589424727 0.861678577307678 MirTarget -0.145859419142528 0.0294111082730724 NA NA NA hsa-miR-15b-5p BEX1 0.251826642099145 0.790709218602499 0.214063751177022 0.773133404300911 miRNAWalker2_validate -0.580594666066984 0.0119165097163551 NA NA NA hsa-miR-139-5p BICD1 -0.0625698939687087 0.914810329989088 -0.0488173476238858 0.917345354453825 miRanda -0.116025793291248 0.034659360171015 NA NA NA hsa-let-7b-5p BIRC5 0.396604576702067 0.783406687058469 -0.283279329611381 0.561187189653315 miRNAWalker2_validate -0.147957849169463 0.014408732522186 NA NA NA hsa-miR-101-3p BIRC5 -0.0149915187591869 0.981999725022451 -0.283279329611381 0.561187189653315 miRNAWalker2_validate -0.309621117466782 1.42405997118488e-06 NA NA NA hsa-miR-30c-5p BIRC5 -0.183013966936985 0.833177718550926 -0.283279329611381 0.561187189653315 miRNAWalker2_validate -0.191856964397765 0.00984494459107499 NA NA NA hsa-miR-130b-3p BLCAP -0.246958204594817 0.524070870130445 0.156351700992247 0.788275662167676 miRNAWalker2_validate;MirTarget;miRNATAP -0.105933918209035 0.000524581138563346 NA NA NA hsa-miR-221-3p BMF -0.261179092929062 0.744019631321393 -0.0417890111864159 0.935049602358016 miRNAWalker2_validate;miRTarBase;miRNATAP -0.326089471305255 5.82706766027774e-09 19671867 MicroRNA 221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality; This study aims to investigate the role of miR-221 in the modulation of Bmf a proapoptotic BH3-only protein and to characterize miR-221 contribution to hepatocarcinogenesis through modulation of apoptosis; Transfection of miR-221 and anti-miR-221 in HCC-derived cell lines and luciferase reporter assay were used to assess Bmf as a target of miR-221; Modulation of miR-221 and Bmf expression contributed to characterize their role in anoikis; Enforced miR-221 expression caused Bmf down-regulation whereas anti-miR-221 induced its up-regulation; A luciferase reporter assay confirmed Bmf as a target of miR-221; Our results indicate that miR-221 by targeting Bmf inhibits apoptosis tumorigenesis liver cancer hsa-miR-222-3p BMF -0.233673471709747 0.726651775432807 -0.0417890111864159 0.935049602358016 miRNATAP -0.32208573511459 6.87007185946616e-09 NA NA NA hsa-miR-148a-3p BMP3 -0.324144803192141 0.746264759480212 -0.0702305581443115 0.910805216417524 MirTarget -0.341425961145396 0.0216369867287721 NA NA NA hsa-miR-22-3p BMP7 0.0468440219945929 0.967778504781139 0.867122741702786 0.271084009545316 miRNAWalker2_validate;miRTarBase -0.314121211679014 0.0275650894839941 NA NA NA hsa-miR-150-5p BMPR1B -0.00683324482969283 0.994067057151257 -0.166367671083546 0.732050447276592 MirTarget -0.137668739773401 0.00180378042874386 NA NA NA hsa-miR-200b-3p BNC2 -0.532909690027328 0.555970111970307 0.552567466492448 0.265538271787922 MirTarget;TargetScan -0.239092116664524 3.72317628329659e-05 NA NA NA hsa-miR-200c-3p BNC2 -0.333638625701646 0.813830738880144 0.552567466492448 0.265538271787922 MirTarget -0.258247619242255 2.60112282209873e-05 NA NA NA hsa-miR-362-5p BNC2 -0.35564884735017 0.452162806620853 0.552567466492448 0.265538271787922 PITA -0.205582646902844 8.75576450608552e-05 NA NA NA hsa-miR-375 BNC2 -0.989394125724925 0.312728638150002 0.552567466492448 0.265538271787922 miRNATAP -0.206165838557855 9.0486488832774e-10 NA NA NA hsa-miR-429 BNC2 -0.596617415946644 0.128967410286089 0.552567466492448 0.265538271787922 MirTarget;PITA;miRNATAP -0.162640515654484 0.00493954919489739 NA NA NA hsa-miR-501-5p BNC2 -0.277968789063541 0.510742720785555 0.552567466492448 0.265538271787922 PITA;miRNATAP -0.19642244173634 0.000697136211267905 NA NA NA hsa-miR-532-5p BNC2 -0.221248694078637 0.810607004905798 0.552567466492448 0.265538271787922 PITA;miRNATAP -0.206840946220197 0.00324801384104499 NA NA NA hsa-miR-93-5p BNC2 -0.375078982324499 0.732311284477601 0.552567466492448 0.265538271787922 miRNATAP -0.183141335835337 0.0223030766545003 NA NA NA hsa-miR-221-3p BNIP3 -0.261179092929062 0.744019631321393 0.184483188613369 0.747457032560203 miRNAWalker2_validate -0.156488964432951 0.00383875700456786 NA NA NA hsa-miR-127-3p BOLA1 0.231539840651733 0.822108193638849 0.0890982196984855 0.815693620934991 miRanda -0.11630776580803 0.000346751941188002 NA NA NA hsa-miR-15b-5p BRSK2 0.251826642099145 0.790709218602499 -0.33402149332374 0.545031240280552 mirMAP -0.580782384444895 0.000541784376526562 NA NA NA hsa-miR-22-3p BRSK2 0.0468440219945929 0.967778504781139 -0.33402149332374 0.545031240280552 MirTarget;miRNATAP -0.30350337202271 0.0153626247895106 NA NA NA hsa-miR-27a-3p BRSK2 0.309634509674364 0.703724209648479 -0.33402149332374 0.545031240280552 MirTarget;miRNATAP -0.449532625797826 0.00152044602383748 NA NA NA hsa-miR-222-3p BRWD3 -0.233673471709747 0.726651775432807 -0.316779338911354 0.336200761675276 MirTarget;miRNATAP -0.129547303768451 0.00276061488130137 NA NA NA hsa-miR-15b-5p BTBD19 0.251826642099145 0.790709218602499 -0.157014899701704 0.650167542949539 mirMAP -0.465335486050508 6.21492477634591e-06 NA NA NA hsa-miR-221-3p BTBD3 -0.261179092929062 0.744019631321393 -0.101207548777849 0.845723759270091 miRNATAP -0.157705358441579 3.92522448840952e-05 NA NA NA hsa-miR-222-3p BTBD3 -0.233673471709747 0.726651775432807 -0.101207548777849 0.845723759270091 miRNATAP -0.179667431632554 2.09314854307281e-06 NA NA NA hsa-miR-22-3p BTF3 0.0468440219945929 0.967778504781139 0.255177379923879 0.728792707057093 miRNAWalker2_validate -0.220582679250491 9.35024782409572e-10 NA NA NA hsa-miR-15b-5p BTG2 0.251826642099145 0.790709218602499 0.11777119556448 0.853263096478147 MirTarget;miRNATAP -0.153436068415509 0.0255538047967593 NA NA NA hsa-miR-139-5p BTN3A1 -0.0625698939687087 0.914810329989088 -0.19925065861017 0.689327314668632 miRanda -0.126212955972188 0.00553427519089384 NA NA NA hsa-miR-15b-5p BTRC 0.251826642099145 0.790709218602499 0.111575075634414 0.791035769071 MirTarget;miRNATAP -0.13371734400723 0.000379992592739498 NA NA NA hsa-miR-660-5p BVES -0.561687438133488 0.138270972367544 -0.208457800759825 0.599770132069546 miRNATAP -0.199586106792667 0.00606445361033671 NA NA NA hsa-miR-98-5p C10orf105 -0.0484028619275874 0.910781316485549 -0.141772237454016 0.678154287145507 mirMAP -0.167319631049303 0.0121339116467583 NA NA NA hsa-miR-197-3p C11orf45 0.0240027695773914 0.981971058073739 0.147041466764163 0.613035924686667 mirMAP -0.130830146711483 0.0407757555392051 NA NA NA hsa-miR-335-3p C1orf115 0.0738544228922926 0.89349398283313 -0.179172876910643 0.667845232281116 mirMAP -0.134453884417917 0.00486189335931737 NA NA NA hsa-miR-27a-3p C1orf21 0.309634509674364 0.703724209648479 0.373416405688308 0.41243946084174 mirMAP;miRNATAP -0.182518330223782 0.00753681953427547 NA NA NA hsa-miR-150-5p C3orf18 -0.00683324482969283 0.994067057151257 -0.0251749198579749 0.933128748647289 miRNATAP -0.100786259499794 6.22874843484828e-05 NA NA NA hsa-miR-107 C5 -0.289737369453023 0.769655185893943 -0.00936249600104522 0.977770121078505 miRanda -0.213780949208935 0.0267291537101959 NA NA NA hsa-miR-146b-5p C6 0.0340352805627226 0.964565988329585 -0.214559694943901 0.734988576185988 miRanda -0.501948729801817 2.61847933576486e-05 NA NA NA hsa-miR-107 C9orf69 -0.289737369453023 0.769655185893943 -0.0280401207632179 0.956947978226639 PITA;miRNATAP -0.121306687128691 0.00139258303198185 NA NA NA hsa-miR-140-3p CABLES1 -0.105651799466207 0.9077781740714 0.182466475237517 0.733712926143519 MirTarget -0.122643229882943 0.044663472230867 NA NA NA hsa-miR-140-3p CABLES2 -0.105651799466207 0.9077781740714 -0.0658221439623237 0.891536295435266 miRNATAP -0.101003562742072 0.0207490839612909 NA NA NA hsa-miR-27a-3p CABP1 0.309634509674364 0.703724209648479 0.0288510228310721 0.936145069789164 miRNATAP -0.235516219714145 0.00482458413070372 NA NA NA hsa-miR-221-3p CABYR -0.261179092929062 0.744019631321393 -0.156406359135168 0.632342662103814 miRNAWalker2_validate;miRNATAP -0.228438146808519 0.000334771887826035 NA NA NA hsa-miR-222-3p CABYR -0.233673471709747 0.726651775432807 -0.156406359135168 0.632342662103814 miRNAWalker2_validate;miRNATAP -0.242529335465493 0.000120805147433046 NA NA NA hsa-miR-107 CACNA1C -0.289737369453023 0.769655185893943 0.321111375195311 0.382866117161134 miRNATAP -0.215624878432062 0.0278533452324335 NA NA NA hsa-miR-150-5p CACNA1D -0.00683324482969283 0.994067057151257 0.35365209282459 0.342756295107948 MirTarget -0.171355505218766 0.000618118153053849 NA NA NA hsa-miR-363-3p CACNA1I -0.186046567396088 0.728622856049059 -0.245425770031336 0.61966341479086 MirTarget -0.217933814284047 0.00147992983819243 NA NA NA hsa-miR-27a-3p CACNB2 0.309634509674364 0.703724209648479 -0.313953873211633 0.173309172489937 MirTarget;miRNATAP -0.161770357341688 0.00524767661728532 NA NA NA hsa-miR-221-3p CACNB4 -0.261179092929062 0.744019631321393 0.103600845313522 0.73606959296772 miRNATAP -0.217790858019531 0.00156189931718751 NA NA NA hsa-miR-222-3p CACNB4 -0.233673471709747 0.726651775432807 0.103600845313522 0.73606959296772 miRNATAP -0.254937793115698 0.000180667672098207 NA NA NA hsa-miR-148a-3p CADM1 -0.324144803192141 0.746264759480212 0.618481003096384 0.291358497692688 MirTarget -0.133116951241011 0.0207339323681916 NA NA NA hsa-miR-363-3p CADM2 -0.186046567396088 0.728622856049059 0.035505313475066 0.962685806609167 MirTarget;mirMAP -0.324356069777611 0.00124918989005649 NA NA NA hsa-miR-98-5p CADM2 -0.0484028619275874 0.910781316485549 0.035505313475066 0.962685806609167 MirTarget -0.461349602810529 0.000853936837650642 NA NA NA hsa-miR-192-5p CADPS2 -0.00281508349767456 0.99638352116085 0.301429763431547 0.478052662787173 miRNAWalker2_validate -0.121694369540925 0.0416619686708575 NA NA NA hsa-miR-92a-3p CALCOCO2 0.0155161307487504 0.991444817308063 0.0157015530510227 0.976272835421285 mirMAP -0.110745934902104 0.00599849453183887 NA NA NA hsa-miR-107 CALD1 -0.289737369453023 0.769655185893943 0.408768742626957 0.567136542717145 miRanda -0.167293165235684 0.00863686304413302 NA NA NA hsa-miR-27a-3p CALM3 0.309634509674364 0.703724209648479 -0.0020415540902885 0.997795063983713 miRNATAP -0.129188665690644 0.00022526084983384 NA NA NA hsa-miR-140-3p CAMK2B -0.105651799466207 0.9077781740714 -0.108926760524682 0.815953660706715 mirMAP -0.365134491006533 0.00393270944275709 NA NA NA hsa-miR-150-5p CAMK2B -0.00683324482969283 0.994067057151257 -0.108926760524682 0.815953660706715 mirMAP -0.263341203941981 5.22286410017336e-05 NA NA NA hsa-miR-106a-5p CAMK2N1 -0.820057689616516 0.0254490146664247 0.000296958894598021 0.999522767231139 miRNATAP -0.159068614514496 0.0171474865088625 NA NA NA hsa-miR-106b-5p CAMK2N1 -0.3941595235172 0.389635342155994 0.000296958894598021 0.999522767231139 miRNATAP -0.606708526619792 1.55246593187381e-09 NA NA NA hsa-miR-146b-3p CAMK2N1 0.306885053271632 0.728850048845534 0.000296958894598021 0.999522767231139 PITA -0.221166088532397 0.0151743828807641 NA NA NA hsa-miR-17-5p CAMK2N1 -0.643066792834501 0.320674049526638 0.000296958894598021 0.999522767231139 TargetScan;miRNATAP -0.337254634317673 4.15337231384847e-05 NA NA NA hsa-miR-182-5p CAMK2N1 -0.262297863136789 0.8110070165759 0.000296958894598021 0.999522767231139 miRNATAP -0.213957945267072 0.000369142183290078 NA NA NA hsa-miR-20a-5p CAMK2N1 -0.857283498361138 0.070259604943771 0.000296958894598021 0.999522767231139 miRNATAP -0.234877398880253 0.000419729767132919 NA NA NA hsa-miR-30a-5p CAMK2N1 -0.163405499812159 0.87950357765238 0.000296958894598021 0.999522767231139 miRNATAP -0.167643807278485 0.0384591131351304 NA NA NA hsa-miR-30c-5p CAMK2N1 -0.183013966936985 0.833177718550926 0.000296958894598021 0.999522767231139 miRNATAP -0.329340172962837 0.00237044675021327 NA NA NA hsa-miR-335-3p CAMK2N1 0.0738544228922926 0.89349398283313 0.000296958894598021 0.999522767231139 mirMAP -0.194364406800854 0.0049736968930546 NA NA NA hsa-miR-93-5p CAMK2N1 -0.375078982324499 0.732311284477601 0.000296958894598021 0.999522767231139 miRNATAP -0.339124335601916 0.00051895836611203 NA NA NA hsa-miR-107 CAMKK1 -0.289737369453023 0.769655185893943 -0.608702847569557 0.0593914838724728 miRNATAP -0.155262940760325 0.0249121919672313 NA NA NA hsa-miR-15b-5p CAMKV 0.251826642099145 0.790709218602499 -0.0367466414413129 0.958227125835942 miRNATAP -0.496363040130566 0.00563819167249271 NA NA NA hsa-miR-127-3p CAMTA1 0.231539840651733 0.822108193638849 0.0427197878498786 0.932067943062932 miRanda -0.117492413367757 2.06423040291402e-05 NA NA NA hsa-miR-221-3p CAMTA1 -0.261179092929062 0.744019631321393 0.0427197878498786 0.932067943062932 MirTarget -0.11189113860202 0.00196786253383554 NA NA NA hsa-miR-107 CAPN2 -0.289737369453023 0.769655185893943 -0.21598812946354 0.75884804498723 miRanda -0.158602042947662 0.00224118424175136 NA NA NA hsa-miR-150-5p CAPN6 -0.00683324482969283 0.994067057151257 0.265780001866761 0.687745300777434 miRNATAP -0.189788596390303 0.0441523735184614 NA NA NA hsa-miR-15b-5p CAPN6 0.251826642099145 0.790709218602499 0.265780001866761 0.687745300777434 miRNATAP -0.4280200453095 0.0368793195099512 NA NA NA hsa-miR-222-3p CAPRIN2 -0.233673471709747 0.726651775432807 -0.447611109435524 0.227579711739209 MirTarget;miRNATAP -0.110521524822757 0.00162358519524578 NA NA NA hsa-miR-15b-5p CARD10 0.251826642099145 0.790709218602499 -0.353385388360056 0.40430230072346 MirTarget;miRNATAP -0.197265298386745 0.0108495362393243 NA NA NA hsa-miR-452-5p CASC1 -0.598209167153363 0.262476098043185 0.118095086140196 0.784454307570877 MirTarget -0.164459224901786 0.00523191342732472 NA NA NA hsa-miR-222-3p CASC3 -0.233673471709747 0.726651775432807 -0.0333995747581204 0.956420042884236 miRNAWalker2_validate -0.146016992091305 1.7881576188967e-07 NA NA NA hsa-miR-107 CASK -0.289737369453023 0.769655185893943 -0.0488754403478229 0.918992944886548 MirTarget;miRanda;miRNATAP -0.102130084761666 0.0174119057195597 NA NA NA hsa-miR-15b-5p CASKIN1 0.251826642099145 0.790709218602499 -0.383094721578343 0.254839292624992 miRNATAP -0.197986474638942 0.0301230147609322 NA NA NA hsa-miR-320a CASQ2 0.142884703798297 0.888511174254355 0.672205701152906 0.107523103070777 miRanda -0.295838503114519 0.00998024302980291 NA NA NA hsa-miR-320b CASQ2 0.298760649675195 0.700446828731538 0.672205701152906 0.107523103070777 miRanda -0.184112267412201 0.0468588115384507 NA NA NA hsa-miR-15b-5p CASR 0.251826642099145 0.790709218602499 -1.23471388291518 0.0944852866809481 miRNATAP -0.695744256640797 0.00146389614197196 NA NA NA hsa-miR-125a-3p CAT 0.124026360619668 0.800539414590835 0.404686327065742 0.500374885372411 miRanda -0.182291578448372 0.000177385314154587 NA NA NA hsa-miR-103a-3p CAV1 -0.360357769638318 0.770748924684999 0.258432670990712 0.628470535082956 miRNAWalker2_validate;miRTarBase -0.151433571683516 0.0151454656140875 NA NA NA hsa-miR-106b-5p CAV1 -0.3941595235172 0.389635342155994 0.258432670990712 0.628470535082956 miRNATAP -0.22418814444974 0.000912587598070048 NA NA NA hsa-miR-615-3p CBS 0.286701660819175 0.572732067119559 -0.132497923887495 0.835924166183081 miRNAWalker2_validate -0.115576065724803 0.0135119274369725 NA NA NA hsa-miR-652-3p CBS -0.220614259848939 0.749215284318257 -0.132497923887495 0.835924166183081 miRNAWalker2_validate -0.188600174569212 0.0493036827849702 NA NA NA hsa-miR-222-3p CBX2 -0.233673471709747 0.726651775432807 -0.792846679860935 0.0825022507964724 miRNAWalker2_validate -0.396603786133147 1.4387236040738e-07 NA NA NA hsa-miR-34a-5p CBX3 -0.689845719362998 0.195745632660671 0.0755673146042355 0.907428624505706 MirTarget -0.10000770312151 0.0014514323055109 NA NA NA hsa-miR-106a-5p CBX7 -0.820057689616516 0.0254490146664247 0.0451177119591932 0.919393625515327 mirMAP -0.139798521694454 0.00018133595939462 NA NA NA hsa-miR-106b-5p CBX7 -0.3941595235172 0.389635342155994 0.0451177119591932 0.919393625515327 mirMAP -0.127443580509311 0.0284846257611883 NA NA NA hsa-miR-1254 CBX7 -0.199064672383384 0.618017470716351 0.0451177119591932 0.919393625515327 MirTarget -0.117634592013562 0.0057643610699046 NA NA NA hsa-miR-129-5p CBX7 0.417083435812871 0.454236109516901 0.0451177119591932 0.919393625515327 MirTarget;PITA;miRanda;miRNATAP -0.120411807102533 0.000142792412838746 NA NA NA hsa-miR-17-5p CBX7 -0.643066792834501 0.320674049526638 0.0451177119591932 0.919393625515327 mirMAP -0.205969215047213 8.46104775943754e-06 NA NA NA hsa-miR-181a-2-3p CBX7 0.158138593715531 0.867246344226279 0.0451177119591932 0.919393625515327 mirMAP -0.323265136496873 6.96759507804826e-10 NA NA NA hsa-miR-181a-5p CBX7 -0.0320774839604816 0.975806098950371 0.0451177119591932 0.919393625515327 MirTarget;miRNATAP -0.132685370414324 0.0175250317891293 NA NA NA hsa-miR-181b-5p CBX7 -0.0483087651223055 0.952929800264921 0.0451177119591932 0.919393625515327 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.259250468964653 1.02607389769465e-06 NA NA NA hsa-miR-18a-3p CBX7 -0.188202012159778 0.618004963641688 0.0451177119591932 0.919393625515327 MirTarget;miRNATAP -0.388002175525824 4.06564233075151e-15 NA NA NA hsa-miR-331-3p CBX7 0.123898581478304 0.82138091232147 0.0451177119591932 0.919393625515327 MirTarget -0.19189600619684 0.0002822491624708 NA NA NA hsa-miR-874-3p CBX7 -0.0860497301267076 0.887664028968527 0.0451177119591932 0.919393625515327 MirTarget -0.152325181298252 0.0103769652870333 NA NA NA hsa-miR-9-5p CBX7 0.029299723902132 0.964227616086639 0.0451177119591932 0.919393625515327 MirTarget -0.110248311162111 4.11440930733239e-05 NA NA NA hsa-miR-93-5p CBX7 -0.375078982324499 0.732311284477601 0.0451177119591932 0.919393625515327 mirMAP -0.192082232280951 0.000485678238406072 NA NA NA hsa-miR-99b-3p CBX7 -0.138069695597469 0.867159046630005 0.0451177119591932 0.919393625515327 MirTarget;miRNATAP -0.299991241503727 1.45977927821309e-05 NA NA NA hsa-miR-125a-3p CBY1 0.124026360619668 0.800539414590835 0.0593925912357687 0.887366283507733 miRanda -0.119494919519468 0.00651349080534919 NA NA NA hsa-miR-330-5p CBY1 -0.152605584680815 0.787259112745893 0.0593925912357687 0.887366283507733 miRanda -0.101883545046096 0.00322005855768993 NA NA NA hsa-miR-221-3p CCDC148 -0.261179092929062 0.744019631321393 0.148807976567331 0.565564208245877 MirTarget -0.120884182571702 0.0419053331625243 NA NA NA hsa-miR-222-3p CCDC148 -0.233673471709747 0.726651775432807 0.148807976567331 0.565564208245877 MirTarget -0.161909544669368 0.00587538869108063 NA NA NA hsa-miR-330-5p CCDC33 -0.152605584680815 0.787259112745893 0.346671767129964 0.509871690687635 miRanda -0.444093280103044 0.00132688804411251 NA NA NA hsa-miR-24-3p CCDC59 0.0408517902063537 0.966828370841971 0.170890689757223 0.687510311887642 miRNAWalker2_validate -0.117107638782196 0.00334838909165699 NA NA NA hsa-miR-107 CCDC68 -0.289737369453023 0.769655185893943 -0.49897610481222 0.101979740893168 miRanda -0.18545748859201 0.037778870981662 NA NA NA hsa-miR-93-3p CCDC69 -0.0244435387315667 0.960677870662158 -0.169191955460793 0.666645944606517 mirMAP -0.157701950333982 0.0209464058626562 NA NA NA hsa-miR-28-5p CCDC81 -0.0511712157419266 0.910958192291954 0.21557524922606 0.594879631974127 miRanda -0.291437003301462 0.017076313287649 NA NA NA hsa-miR-128-3p CCL17 -0.0364518492233463 0.95841670253784 -0.150904145319998 0.805686797706974 miRNAWalker2_validate -0.409152129654245 0.0164471118743051 NA NA NA hsa-miR-338-3p CCL21 -0.107178830331044 0.818042702366464 1.41409604912118 0.09721956164831 miRNATAP -0.39936745329594 0.00558324284117034 NA NA NA hsa-let-7b-3p CCNA2 0.314328399485033 0.684245834514538 -0.245287007158474 0.619358687669537 MirTarget -0.196847857448295 0.000740742796544093 NA NA NA hsa-let-7b-5p CCNA2 0.396604576702067 0.783406687058469 -0.245287007158474 0.619358687669537 miRNAWalker2_validate;miRTarBase -0.206979614529727 0.000108718994287637 NA NA NA hsa-miR-199a-5p CCNA2 0.248253058498817 0.7461266806999 -0.245287007158474 0.619358687669537 miRanda -0.108304227915204 0.00614372572750515 NA NA NA hsa-miR-29a-3p CCNA2 0.203872357562561 0.859946061784007 -0.245287007158474 0.619358687669537 MirTarget -0.251838793381907 2.3374039779425e-06 NA NA NA hsa-miR-320c CCNA2 0.092255964601645 0.785539881268253 -0.245287007158474 0.619358687669537 miRanda -0.230325229890982 4.54343124046485e-06 NA NA NA hsa-miR-320d CCNA2 0.353471568894745 0.357430999251147 -0.245287007158474 0.619358687669537 miRanda -0.134799479415331 0.000666360539573474 NA NA NA hsa-let-7b-5p CCNB1 0.396604576702067 0.783406687058469 -0.0857621625874234 0.874517751168966 miRNAWalker2_validate -0.166562663562261 0.000780252185734729 NA NA NA hsa-let-7a-5p CCNB2 0.0514604984725615 0.971564723582327 0.129563822594162 0.796127661312511 miRNAWalker2_validate -0.25030967126738 0.000130636688037291 NA NA NA hsa-let-7b-5p CCNB2 0.396604576702067 0.783406687058469 0.129563822594162 0.796127661312511 miRNAWalker2_validate -0.186455538720665 0.000295327948551031 NA NA NA hsa-miR-150-5p CCND1 -0.00683324482969283 0.994067057151257 -0.0380322966451638 0.958702612238351 mirMAP -0.151404606197238 0.00428892796990735 NA NA NA hsa-miR-15b-5p CCND1 0.251826642099145 0.790709218602499 -0.0380322966451638 0.958702612238351 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.486632084367106 2.07935568901809e-05 NA NA NA hsa-let-7b-3p CCND2 0.314328399485033 0.684245834514538 0.203692656022289 0.732335574960748 mirMAP -0.256196872822604 0.01424007703687 NA NA NA hsa-let-7b-5p CCND2 0.396604576702067 0.783406687058469 0.203692656022289 0.732335574960748 miRNAWalker2_validate;miRTarBase;miRNATAP -0.195672995601767 0.0420829035580873 NA NA NA hsa-miR-151a-3p CCND2 -0.281256460812097 0.785995341812949 0.203692656022289 0.732335574960748 mirMAP -0.38497894674161 0.00124752664367036 NA NA NA hsa-miR-15b-5p CCND2 0.251826642099145 0.790709218602499 0.203692656022289 0.732335574960748 miRNATAP -0.501131199417313 4.20957512669768e-05 NA NA NA hsa-miR-186-5p CCND2 -0.246324984406451 0.701310703524093 0.203692656022289 0.732335574960748 mirMAP;miRNATAP -0.341302438468369 0.00676423896613937 NA NA NA hsa-miR-21-3p CCND2 0.129101420041684 0.877913267462969 0.203692656022289 0.732335574960748 mirMAP -0.371951160275752 2.13025775516859e-06 NA NA NA hsa-miR-378a-3p CCND2 -0.428786733400143 0.628789899706565 0.203692656022289 0.732335574960748 miRNAWalker2_validate -0.202709842691012 0.00712592270118009 NA NA NA hsa-miR-429 CCND2 -0.596617415946644 0.128967410286089 0.203692656022289 0.732335574960748 miRNATAP -0.20293798859469 0.00862013169732758 NA NA NA hsa-miR-500a-5p CCND2 -0.232217839578781 0.516569510502181 0.203692656022289 0.732335574960748 mirMAP -0.287854839068181 0.000406316332148997 NA NA NA hsa-miR-501-5p CCND2 -0.277968789063541 0.510742720785555 0.203692656022289 0.732335574960748 PITA;mirMAP;miRNATAP -0.248113649990071 0.00134107441617918 NA NA NA hsa-miR-550a-5p CCND2 -0.0350873420737576 0.935572590907923 0.203692656022289 0.732335574960748 MirTarget -0.273068444539204 0.00128731073587978 NA NA NA hsa-miR-616-5p CCND2 -0.321509218120179 0.271446046739636 0.203692656022289 0.732335574960748 mirMAP -0.173387982380883 0.0355698657226611 NA NA NA hsa-miR-636 CCND2 -0.112545138850734 0.710621887575005 0.203692656022289 0.732335574960748 mirMAP -0.169953089020846 0.0461381386678513 NA NA NA hsa-miR-660-5p CCND2 -0.561687438133488 0.138270972367544 0.203692656022289 0.732335574960748 mirMAP -0.214526271095927 0.0040314174331345 NA NA NA hsa-miR-663b CCND2 0.384277517864011 0.321469889770093 0.203692656022289 0.732335574960748 MirTarget;miRNATAP -0.171845912692712 0.0228253884777984 NA NA NA hsa-miR-15b-5p CCND3 0.251826642099145 0.790709218602499 -0.0411641939215723 0.945055768590678 miRNATAP -0.125173467700277 0.0149522195931355 NA NA NA hsa-miR-127-3p CCNDBP1 0.231539840651733 0.822108193638849 0.414158576379684 0.388302045709077 miRanda -0.109599649725143 0.000132718308916266 NA NA NA hsa-miR-125b-5p CCNE1 0.0074438975183444 0.994154663318355 -0.0968089967827854 0.856512453395965 miRNAWalker2_validate -0.273103619049784 0.000793540188306587 NA NA NA hsa-miR-26a-5p CCNE1 0.0483232931294246 0.955218190818435 -0.0968089967827854 0.856512453395965 miRNAWalker2_validate;miRTarBase;miRNATAP -0.244534968712965 0.0285293355820038 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-27a-3p CCNG1 0.309634509674364 0.703724209648479 0.0558850639910746 0.9317684777928 MirTarget;miRNATAP -0.151328784382279 0.00283350828041358 NA NA NA hsa-miR-15b-5p CCNT1 0.251826642099145 0.790709218602499 -0.127323406729269 0.676053684573103 miRNATAP -0.123240551539809 0.00976732461284083 NA NA NA hsa-miR-27a-3p CCNT1 0.309634509674364 0.703724209648479 -0.127323406729269 0.676053684573103 miRNATAP -0.107195234700436 0.00765283061547858 NA NA NA hsa-miR-15b-5p CCNT2 0.251826642099145 0.790709218602499 -0.209287474969924 0.64354693040583 MirTarget;miRNATAP -0.104518737536738 0.0046287568304185 NA NA NA hsa-miR-27a-3p CCNT2 0.309634509674364 0.703724209648479 -0.209287474969924 0.64354693040583 MirTarget -0.102038446102214 0.00101180762271689 NA NA NA hsa-miR-139-5p CCT2 -0.0625698939687087 0.914810329989088 0.107309693664384 0.866651833814768 miRanda -0.115198312909679 0.000717763592591641 NA NA NA hsa-miR-221-3p CCT3 -0.261179092929062 0.744019631321393 0.0230856546375673 0.974752842298538 miRNAWalker2_validate -0.122697837462196 1.49008938421669e-06 NA NA NA hsa-miR-214-3p CD164L2 0.0312810611346688 0.952640488671912 0.00269628787011822 0.994756155742427 mirMAP -0.209626490678752 0.00130469065092215 NA NA NA hsa-miR-128-3p CD276 -0.0364518492233463 0.95841670253784 -0.0189334226707434 0.975601417820928 MirTarget -0.100870829193401 0.0167544092202807 NA NA NA hsa-miR-107 CD302 -0.289737369453023 0.769655185893943 0.185639271932675 0.669001620682745 miRanda -0.132885645162752 0.0178692863053616 NA NA NA hsa-miR-194-5p CD302 -0.141051051043955 0.809072276924359 0.185639271932675 0.669001620682745 mirMAP -0.123579478293419 0.000672795831962701 NA NA NA hsa-miR-30b-5p CD302 -0.298771188216537 0.582864939841563 0.185639271932675 0.669001620682745 mirMAP -0.154332928596553 0.000470042065841606 NA NA NA hsa-miR-30d-5p CD302 -0.127037899273548 0.917197761243139 0.185639271932675 0.669001620682745 mirMAP -0.115199862410596 0.0328308495053559 NA NA NA hsa-miR-214-3p CD320 0.0312810611346688 0.952640488671912 0.132640877137274 0.801588667786061 MirTarget -0.11224350035696 0.000339230222394794 NA NA NA hsa-miR-1275 CD44 0.524790554828265 0.301913533762167 -0.0622597741704602 0.916658316498726 MirTarget -0.116755155867839 0.00247054588132449 NA NA NA hsa-miR-181a-2-3p CD44 0.158138593715531 0.867246344226279 -0.0622597741704602 0.916658316498726 MirTarget -0.253930241414498 0.000110619401042637 NA NA NA hsa-miR-296-3p CD44 0.305371903227786 0.470342914513253 -0.0622597741704602 0.916658316498726 miRanda -0.124670211130539 0.00730814712431958 NA NA NA hsa-miR-30c-1-3p CD44 0.140640717600046 0.633563796650597 -0.0622597741704602 0.916658316498726 MirTarget -0.220526394148518 0.000364225596169559 NA NA NA hsa-miR-30e-3p CD44 0.202355073367528 0.857417040078429 -0.0622597741704602 0.916658316498726 mirMAP -0.229787217392974 0.00473156613219392 NA NA NA hsa-miR-328-3p CD44 0.326635455247326 0.676255782778498 -0.0622597741704602 0.916658316498726 miRNAWalker2_validate;miRTarBase -0.198556262969531 0.0024795249001232 NA NA NA hsa-let-7e-5p CD59 -0.421901553764044 0.703151344854989 0.242936482451826 0.747309313127959 MirTarget -0.102195998784677 0.0378495434404301 NA NA NA hsa-miR-335-3p CD59 0.0738544228922926 0.89349398283313 0.242936482451826 0.747309313127959 mirMAP -0.150215744366722 1.52740254870681e-06 NA NA NA hsa-miR-107 CD79A -0.289737369453023 0.769655185893943 -0.55822696584596 0.375861773647173 miRanda -0.380469493622741 0.0443544086725178 NA NA NA hsa-miR-125a-5p CDC23 -0.00666761469427968 0.994891296705929 0.0127999166674506 0.979389985529631 miRanda -0.128090792984643 0.00318535009249539 NA NA NA hsa-miR-107 CDC42EP2 -0.289737369453023 0.769655185893943 0.0286474952424243 0.936744251213271 miRanda;miRNATAP -0.125844451668426 0.00960658341365622 NA NA NA hsa-miR-27a-3p CDC42EP3 0.309634509674364 0.703724209648479 0.353408029260419 0.464310834434881 MirTarget -0.114555611909649 0.00845856569870079 NA NA NA hsa-let-7a-5p CDC7 0.0514604984725615 0.971564723582327 -0.270044306973006 0.462810912865871 miRNAWalker2_validate -0.264311584845163 0.00010886431039106 NA NA NA hsa-miR-101-3p CDC7 -0.0149915187591869 0.981999725022451 -0.270044306973006 0.462810912865871 miRNAWalker2_validate -0.183808843844902 0.00156622131870364 NA NA NA hsa-miR-199a-5p CDC7 0.248253058498817 0.7461266806999 -0.270044306973006 0.462810912865871 MirTarget;miRanda -0.133913437011581 0.00071026568595736 NA NA NA hsa-let-7e-5p CDCA3 -0.421901553764044 0.703151344854989 -0.162886856770112 0.705916895556495 miRNAWalker2_validate -0.131695100270056 0.0316132335821895 NA NA NA hsa-miR-26b-5p CDCA3 0.16143906971203 0.790777916193478 -0.162886856770112 0.705916895556495 miRNAWalker2_validate -0.137138545926928 0.0449661798020509 NA NA NA hsa-miR-320c CDCA3 0.092255964601645 0.785539881268253 -0.162886856770112 0.705916895556495 miRanda -0.180181076701393 0.000133709774499449 NA NA NA hsa-miR-320d CDCA3 0.353471568894745 0.357430999251147 -0.162886856770112 0.705916895556495 miRanda -0.116172223574609 0.00171405785546545 NA NA NA hsa-miR-141-3p CDCA4 -0.36932301319088 0.428364456128406 0.0492719631478078 0.922539364607485 mirMAP -0.177650683817633 1.21421687303443e-05 NA NA NA hsa-miR-29a-3p CDCA4 0.203872357562561 0.859946061784007 0.0492719631478078 0.922539364607485 MirTarget -0.157948498235675 0.000116589679601117 NA NA NA hsa-miR-29c-3p CDCA4 0.042533372292219 0.941334605544826 0.0492719631478078 0.922539364607485 MirTarget -0.141392473103673 2.16815434752115e-05 NA NA NA hsa-miR-140-3p CDCA7 -0.105651799466207 0.9077781740714 -0.779595264707178 0.0737420434441484 MirTarget -0.173371277836886 0.0368117209825487 NA NA NA hsa-miR-22-3p CDCA7L 0.0468440219945929 0.967778504781139 0.0900202816109656 0.865363255653899 MirTarget -0.18479337381065 0.000143282192721079 NA NA NA hsa-let-7a-5p CDCA8 0.0514604984725615 0.971564723582327 -0.178368462944935 0.723096340985262 TargetScan -0.252235238649285 0.000349194987699088 NA NA NA hsa-let-7b-5p CDCA8 0.396604576702067 0.783406687058469 -0.178368462944935 0.723096340985262 miRNAWalker2_validate -0.234493011178393 2.16482269831227e-05 NA NA NA hsa-miR-139-5p CDH1 -0.0625698939687087 0.914810329989088 -0.0891790633490537 0.902378985630649 PITA;miRanda -0.113583761492961 0.0343615320777839 NA NA NA hsa-miR-125a-5p CDH12 -0.00666761469427968 0.994891296705929 0.0561984533940241 0.942807601597676 miRanda -0.715158921295443 0.0271526354745505 NA NA NA hsa-miR-365a-5p CDH12 -0.0793405119778852 0.800861924562577 0.0561984533940241 0.942807601597676 MirTarget -0.447447602660046 0.0196118638296584 NA NA NA hsa-miR-107 CDH13 -0.289737369453023 0.769655185893943 0.136596825579346 0.760054298694383 miRanda -0.23910261041345 0.0412149888066454 NA NA NA hsa-miR-660-5p CDH13 -0.561687438133488 0.138270972367544 0.136596825579346 0.760054298694383 MirTarget -0.209306209159872 0.00419561789331509 NA NA NA hsa-miR-27a-3p CDH24 0.309634509674364 0.703724209648479 -0.543426139371903 0.182615790878281 miRNATAP -0.148463352885657 0.0151656545211692 NA NA NA hsa-miR-129-5p CDH6 0.417083435812871 0.454236109516901 0.3723353815836 0.610993029180507 mirMAP -0.252794895444489 0.000167418085485731 NA NA NA hsa-miR-664a-3p CDH6 -0.139841943049965 0.800834383581795 0.3723353815836 0.610993029180507 mirMAP -0.299631445487676 0.012419721473701 NA NA NA hsa-miR-150-5p CDHR3 -0.00683324482969283 0.994067057151257 -0.0921588370859039 0.841504952476685 mirMAP -0.352665927261681 3.58451274406882e-08 NA NA NA hsa-miR-197-3p CDK10 0.0240027695773914 0.981971058073739 -0.219498333195412 0.631520180324291 miRNAWalker2_validate -0.130678114442272 0.00794441202509658 NA NA NA hsa-miR-148a-3p CDK19 -0.324144803192141 0.746264759480212 0.0698767518944257 0.877595904542025 miRNAWalker2_validate;MirTarget;miRNATAP -0.134779593596043 0.000185528876684986 NA NA NA hsa-miR-221-3p CDK19 -0.261179092929062 0.744019631321393 0.0698767518944257 0.877595904542025 MirTarget;miRNATAP -0.103303439331592 0.00397372297463864 NA NA NA hsa-miR-222-3p CDK19 -0.233673471709747 0.726651775432807 0.0698767518944257 0.877595904542025 MirTarget;miRNATAP -0.117437418104243 0.000940500344911353 NA NA NA hsa-miR-148a-3p CDK5R1 -0.324144803192141 0.746264759480212 0.00205021992534071 0.993457617313561 MirTarget;miRNATAP -0.133044642732201 0.0109137407574109 NA NA NA hsa-miR-15b-5p CDK5R1 0.251826642099145 0.790709218602499 0.00205021992534071 0.993457617313561 MirTarget;miRNATAP -0.169557801104741 0.0128193277939986 NA NA NA hsa-miR-27a-3p CDK5R1 0.309634509674364 0.703724209648479 0.00205021992534071 0.993457617313561 miRNATAP -0.183668394941203 0.00133127987659913 NA NA NA hsa-miR-660-5p CDK6 -0.561687438133488 0.138270972367544 0.414885735799475 0.451923918792095 mirMAP -0.128303639203854 0.0415531123026267 NA NA NA hsa-miR-101-3p CDKN1A -0.0149915187591869 0.981999725022451 -0.0951986460638592 0.858703374180151 MirTarget -0.184578426708756 0.00180867777091077 NA NA NA hsa-miR-106b-5p CDKN1A -0.3941595235172 0.389635342155994 -0.0951986460638592 0.858703374180151 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.183221648724674 0.00429127209322526 NA NA NA hsa-miR-182-5p CDKN1A -0.262297863136789 0.8110070165759 -0.0951986460638592 0.858703374180151 miRNAWalker2_validate -0.124613183431244 0.000890366640202779 NA NA NA hsa-miR-221-3p CDKN1B -0.261179092929062 0.744019631321393 -0.0298593007991652 0.955867819488336 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.186502167388942 3.34710434896951e-06 20461750;23637992;19953484;23939688;19126397;20146005;23967190;17569667;22992757;17721077 MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression;miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR poor survival;progression;;;;staging;tumorigenesis;;;; ovarian cancer;breast cancer;glioblastoma;breast cancer;melanoma;liver cancer;pancreatic cancer;prostate cancer;breast cancer;glioblastoma hsa-miR-222-3p CDKN1B -0.233673471709747 0.726651775432807 -0.0298593007991652 0.955867819488336 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.171905428967177 1.65425282255054e-05 24137356;20461750;19953484;26912358;24895988;17569667;27282281 miR 222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1; miR-222 upregulation induced an enhancement of ovarian cancer cell proliferation potential possibly by downregulating its target P27Kip1; A bioinformatic analysis showed that the 3'-UTR of the P27Kip1 mRNA contained a highly-conserved putative miR-222 binding site; Luciferase reporter assays demonstrated that P27Kip1 was a direct target of miR-222; Consistently there was an inverse correlation between the P27Kip1 and miR-222 expression levels in the ovarian cancer cell lines and tissues;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;Besides microvesicle marker characterization we evidenced that miR-222 exosomal expression mostly reflected its abundance in the cells of origin correctly paralleled by repression of its target genes such as p27Kip1 and induction of the PI3K/AKT pathway thus confirming its functional implication in cancer;MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;miR 222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27kip1 expression; Immunofluorescence showed that miR-222 altered the subcellular location of p27kip1 in nucleus; The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis and arrested the cells in G1 phase accompanied by more expressions of p27kip1 especially in nucleus; Taken together the results found that miR-222 induced Adr-resistance at least in part via suppressing p27kip1 expression and altering its subcellular localization and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells ;poor survival;;;tumorigenesis;;drug resistance ovarian cancer;ovarian cancer;glioblastoma;melanoma;cervical and endocervical cancer;prostate cancer;breast cancer hsa-miR-221-3p CDKN1C -0.261179092929062 0.744019631321393 -0.177123859611887 0.729805443825028 miRNAWalker2_validate;miRTarBase;miRNATAP -0.241750058879105 0.000270915923334854 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-222-3p CDKN1C -0.233673471709747 0.726651775432807 -0.177123859611887 0.729805443825028 miRNAWalker2_validate;miRTarBase;miRNATAP -0.226463753663193 0.00059474086646118 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-363-3p CDKN1C -0.186046567396088 0.728622856049059 -0.177123859611887 0.729805443825028 MirTarget -0.112218971660057 0.00591285656807397 NA NA NA hsa-miR-125a-5p CDKN2A -0.00666761469427968 0.994891296705929 -0.0646446653565391 0.92972553014323 miRanda -0.438725420405951 0.0366456772628833 NA NA NA hsa-miR-125b-5p CDKN2A 0.0074438975183444 0.994154663318355 -0.0646446653565391 0.92972553014323 miRNAWalker2_validate -0.343398398127398 0.00496143365765007 23585871 In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b; Conversely treatment of prostate cancer cells with an inhibitor of miR-125b anti-miR-125b resulted in increased expression of p14ARF decreased level of Mdm2 and induction of apoptosis; In addition overexpression of miR-125b in p53-deficient PC3 cells induced down-regulation of p14ARF which leads to increased cell proliferation through a p53-independent manner prostate cancer hsa-miR-455-3p CDKN2A 0.112667549349787 0.88195515618473 -0.0646446653565391 0.92972553014323 miRNAWalker2_validate -0.25286776123497 0.0281583821577158 NA NA NA hsa-miR-150-5p CDON -0.00683324482969283 0.994067057151257 -0.0398457745119654 0.935862654529542 mirMAP -0.105055347703422 0.00323595215120754 NA NA NA hsa-miR-125a-5p CDR2L -0.00666761469427968 0.994891296705929 -0.0477293452640231 0.942144870977367 MirTarget;PITA;miRanda -0.372210420403447 0.00158168484234304 NA NA NA hsa-miR-125b-5p CDR2L 0.0074438975183444 0.994154663318355 -0.0477293452640231 0.942144870977367 MirTarget;miRNATAP -0.287155308970043 2.65178674683659e-05 NA NA NA hsa-miR-320c CDR2L 0.092255964601645 0.785539881268253 -0.0477293452640231 0.942144870977367 mirMAP -0.148718118675322 0.0225713678595145 NA NA NA hsa-miR-26a-5p CEBPG 0.0483232931294246 0.955218190818435 -0.268143444785805 0.590816277293831 miRNATAP -0.12252512764084 0.0204182191400426 NA NA NA hsa-miR-664a-3p CEBPG -0.139841943049965 0.800834383581795 -0.268143444785805 0.590816277293831 mirMAP -0.143025662264785 0.0010817593205878 NA NA NA hsa-miR-98-5p CELF3 -0.0484028619275874 0.910781316485549 -0.0851278400717028 0.906099412096923 MirTarget -0.412037237432879 0.000194358412726836 NA NA NA hsa-miR-148a-3p CELSR1 -0.324144803192141 0.746264759480212 -0.060546835229248 0.926445543173268 MirTarget -0.134618126071796 0.0113716954036791 NA NA NA hsa-miR-199a-5p CENPA 0.248253058498817 0.7461266806999 0.0263868074682909 0.947008771149817 miRanda -0.114963973340465 0.00947559493062346 NA NA NA hsa-miR-320c CENPE 0.092255964601645 0.785539881268253 -0.0142078827320495 0.967063065465956 miRanda -0.13517532309346 0.00824390021562855 NA NA NA hsa-miR-320c CENPN 0.092255964601645 0.785539881268253 -0.0400951296534746 0.919778206977485 miRanda -0.144609757220221 0.000106387203195615 NA NA NA hsa-miR-22-3p CENPV 0.0468440219945929 0.967778504781139 0.115471172764651 0.772077028099417 MirTarget -0.262664993383004 0.00232139696998833 NA NA NA hsa-miR-194-5p CEP170 -0.141051051043955 0.809072276924359 -0.0121073734476571 0.978305880709427 miRNATAP -0.115768260268857 0.000110886203136018 NA NA NA hsa-miR-664a-5p CEP70 -0.19612479730604 0.558657187130445 -0.178487914817469 0.67501688140486 MirTarget -0.111426256774821 0.00125128887168385 NA NA NA hsa-miR-107 CERK -0.289737369453023 0.769655185893943 0.166337448018345 0.753141392543604 mirMAP -0.261659112084135 5.22709778029344e-07 NA NA NA hsa-miR-128-3p CERK -0.0364518492233463 0.95841670253784 0.166337448018345 0.753141392543604 miRNAWalker2_validate -0.137645462234031 0.0127276110343203 NA NA NA hsa-miR-320a CES1 0.142884703798297 0.888511174254355 0.234232169832324 0.720490879923885 miRanda -0.40493485607965 0.0252212264092154 NA NA NA hsa-miR-320b CES1 0.298760649675195 0.700446828731538 0.234232169832324 0.720490879923885 miRanda -0.397942811531563 0.00617341922342266 NA NA NA hsa-miR-320d CES1 0.353471568894745 0.357430999251147 0.234232169832324 0.720490879923885 miRanda -0.235297717915853 0.043745357862008 NA NA NA hsa-miR-221-3p CHCHD2 -0.261179092929062 0.744019631321393 0.428750321860901 0.531733173269578 miRNAWalker2_validate -0.148478939446517 6.01026228831901e-05 NA NA NA hsa-miR-15b-5p CHD9 0.251826642099145 0.790709218602499 0.0487058628905936 0.917374585656107 miRNATAP -0.15065814609707 0.000360679307515265 NA NA NA hsa-miR-199a-5p CHODL 0.248253058498817 0.7461266806999 0.128777595492083 0.796088282506019 miRanda -0.207579423581588 0.00218158196290641 NA NA NA hsa-miR-323a-3p CHODL 0.515986769154502 0.275467412974017 0.128777595492083 0.796088282506019 MirTarget -0.210927709966075 9.09679026596579e-05 NA NA NA hsa-miR-15b-5p CHPF 0.251826642099145 0.790709218602499 0.164798408052501 0.808217354722435 miRNAWalker2_validate -0.210849265667649 0.000255067152609516 NA NA NA hsa-miR-27a-3p CHRM1 0.309634509674364 0.703724209648479 0.193298593054021 0.748997195772092 miRNATAP -0.278063671322202 0.0489487761095914 NA NA NA hsa-miR-150-5p CHRNA7 -0.00683324482969283 0.994067057151257 0.414494134653933 0.417438454118818 mirMAP -0.14735846272629 0.0200052097010977 NA NA NA hsa-miR-25-3p CHST1 0.0681841609869576 0.955267320175687 -0.114757828015408 0.836754162719385 MirTarget -0.530999956039279 1.86007952596673e-05 NA NA NA hsa-miR-30a-5p CHST1 -0.163405499812159 0.87950357765238 -0.114757828015408 0.836754162719385 MirTarget -0.21494666671974 0.00920899230953894 NA NA NA hsa-miR-30c-5p CHST1 -0.183013966936985 0.833177718550926 -0.114757828015408 0.836754162719385 MirTarget -0.263798594978911 0.0174852615290973 NA NA NA hsa-miR-92a-3p CHST1 0.0155161307487504 0.991444817308063 -0.114757828015408 0.836754162719385 MirTarget -0.248427910377112 0.0383831931035127 NA NA NA hsa-miR-200b-3p CHST2 -0.532909690027328 0.555970111970307 -0.124060529071464 0.796648759020459 TargetScan -0.176478633375195 0.00145641577227502 NA NA NA hsa-miR-200c-3p CHST2 -0.333638625701646 0.813830738880144 -0.124060529071464 0.796648759020459 miRNATAP -0.129784207326886 0.0278800245975095 NA NA NA hsa-miR-26a-5p CHST2 0.0483232931294246 0.955218190818435 -0.124060529071464 0.796648759020459 miRNATAP -0.20671885773653 0.0271079729955285 NA NA NA hsa-miR-30d-5p CHST2 -0.127037899273548 0.917197761243139 -0.124060529071464 0.796648759020459 MirTarget;miRNATAP -0.226578106647852 0.00549961333075516 NA NA NA hsa-miR-30e-5p CHST2 -0.00273037859886571 0.997115479601006 -0.124060529071464 0.796648759020459 MirTarget -0.164177963541773 0.0447868725421161 NA NA NA hsa-miR-181a-2-3p CHST4 0.158138593715531 0.867246344226279 0.384442741975404 0.400605290141631 MirTarget -0.234066534809232 0.0422519699726331 NA NA NA hsa-miR-15b-5p CIAPIN1 0.251826642099145 0.790709218602499 0.102878812174225 0.83253586475493 miRNATAP -0.119254125449004 0.00108623745682377 NA NA NA hsa-miR-339-5p CIRBP -0.121565674268033 0.81427862647099 -0.15524006985529 0.794177535714845 miRanda -0.108183275641576 0.00412832458225251 NA NA NA hsa-miR-532-3p CIRBP 0.102082509259256 0.893896651717717 -0.15524006985529 0.794177535714845 PITA;miRNATAP -0.114321986168456 0.000253402638243821 NA NA NA hsa-miR-629-3p CIRBP -0.455149050361454 0.209212127982437 -0.15524006985529 0.794177535714845 mirMAP -0.121854615307743 0.000175413878698513 NA NA NA hsa-miR-30d-5p CIT -0.127037899273548 0.917197761243139 -0.268067474332771 0.554390582412989 miRNATAP -0.160543723161863 0.0126807653715506 NA NA NA hsa-miR-222-3p CKAP2 -0.233673471709747 0.726651775432807 0.197031620415563 0.695920159795526 miRNAWalker2_validate -0.182953550987338 1.01433359018581e-06 NA NA NA hsa-miR-28-5p CKAP2 -0.0511712157419266 0.910958192291954 0.197031620415563 0.695920159795526 miRanda;miRNATAP -0.163594206831092 0.00104904501082727 NA NA NA hsa-let-7b-5p CKB 0.396604576702067 0.783406687058469 -0.159323505984196 0.807587685096565 miRNAWalker2_validate -0.306427031363654 7.23675044665501e-05 NA NA NA hsa-miR-125a-5p CKS1B -0.00666761469427968 0.994891296705929 0.0907882033095921 0.866320295715686 miRanda -0.228461067865464 0.00329290112235665 NA NA NA hsa-miR-361-5p CKS1B -0.278147578656315 0.728553069590798 0.0907882033095921 0.866320295715686 MirTarget;PITA;miRanda -0.204202923798854 0.00534868566742404 NA NA NA hsa-miR-27a-3p CLCN5 0.309634509674364 0.703724209648479 -0.178150103511938 0.678345961474735 miRNATAP -0.168883109115206 0.00560334142697861 NA NA NA hsa-miR-197-3p CLCN6 0.0240027695773914 0.981971058073739 -0.35264349176048 0.440353528550254 mirMAP -0.109165918461056 0.0387435133896412 NA NA NA hsa-miR-181d-5p CLDN10 -0.294264170071504 0.604392929232074 -0.561280495436716 0.45376012675638 MirTarget -0.405920376348325 0.000603477518302724 NA NA NA hsa-miR-30c-5p CLDN10 -0.183013966936985 0.833177718550926 -0.561280495436716 0.45376012675638 mirMAP -0.553109294823555 0.00297021694991732 NA NA NA hsa-miR-15b-5p CLDN19 0.251826642099145 0.790709218602499 0.059322408640073 0.943480447727919 mirMAP -0.630541777380938 0.0124055978839439 NA NA NA hsa-miR-139-5p CLDN4 -0.0625698939687087 0.914810329989088 0.263129602763007 0.741420136203289 miRanda -0.106671697630768 0.0386952875570835 NA NA NA hsa-miR-128-3p CLDN5 -0.0364518492233463 0.95841670253784 0.0540636984812322 0.875249559008165 miRNAWalker2_validate -0.215245521773092 0.00278696158880902 NA NA NA hsa-miR-146b-5p CLN5 0.0340352805627226 0.964565988329585 -0.0265828127364536 0.955851221366943 miRanda -0.135444053764113 7.61989102789331e-05 NA NA NA hsa-miR-361-5p CLN5 -0.278147578656315 0.728553069590798 -0.0265828127364536 0.955851221366943 miRanda -0.157717407310035 0.020765595818102 NA NA NA hsa-miR-18a-3p CLU -0.188202012159778 0.618004963641688 0.616613404504326 0.551764670349602 miRNAWalker2_validate -0.57217570082354 1.18932498655054e-08 NA NA NA hsa-miR-22-3p CLUAP1 0.0468440219945929 0.967778504781139 -0.00326639480893487 0.99355209405024 mirMAP -0.222504968840014 2.15825624973182e-11 NA NA NA hsa-miR-27b-5p CLUAP1 0.188364926679735 0.652141909489174 -0.00326639480893487 0.99355209405024 mirMAP -0.115809919443 0.000575985934154016 NA NA NA hsa-miR-330-3p CLUAP1 -0.1562229971038 0.692313620862782 -0.00326639480893487 0.99355209405024 mirMAP -0.104613046232132 0.00307200487751913 NA NA NA hsa-miR-93-5p CLUAP1 -0.375078982324499 0.732311284477601 -0.00326639480893487 0.99355209405024 mirMAP -0.125854366401283 0.00162106683868704 NA NA NA hsa-miR-150-5p CLVS1 -0.00683324482969283 0.994067057151257 0.973271916736074 0.0495428742044872 MirTarget -0.169124795933009 0.016843715135609 NA NA NA hsa-miR-139-5p CMTM8 -0.0625698939687087 0.914810329989088 0.399954730738463 0.32636259314685 miRanda -0.172028248280328 0.000108107106559458 NA NA NA hsa-miR-10b-5p CNN1 -0.866656492462537 0.502462749031016 0.848270712129176 0.063962125805562 MirTarget -0.238949313200738 7.53981939565426e-05 NA NA NA hsa-miR-107 CNN3 -0.289737369453023 0.769655185893943 0.0186698260916538 0.978179984744105 miRanda -0.106417371048869 0.0139226065344594 NA NA NA hsa-miR-139-5p CNPY2 -0.0625698939687087 0.914810329989088 0.335553926100576 0.562197463390072 miRanda -0.102152211281942 0.00133201465549285 NA NA NA hsa-miR-150-5p CNTN2 -0.00683324482969283 0.994067057151257 0.0626820159997719 0.905077114687592 mirMAP -0.153123832299629 0.024925931565515 NA NA NA hsa-miR-107 CNTN3 -0.289737369453023 0.769655185893943 0.636683117253605 0.280139316644036 miRanda -0.357200981542095 0.0395290701701377 NA NA NA hsa-miR-148a-3p CNTN4 -0.324144803192141 0.746264759480212 0.390138807453628 0.485800322944399 miRNATAP -0.342355257988102 0.00963581632901365 NA NA NA hsa-miR-148a-3p CNTNAP2 -0.324144803192141 0.746264759480212 -0.0770204022468783 0.896926055209536 mirMAP -0.300358285603174 0.0324224445626005 NA NA NA hsa-miR-27a-3p CNTNAP2 0.309634509674364 0.703724209648479 -0.0770204022468783 0.896926055209536 miRNATAP -0.370581347204161 0.0161764189903491 NA NA NA hsa-miR-1271-5p COBL -0.123660425893253 0.703530688988424 0.19682848427447 0.699601093424534 MirTarget -0.160367444434666 0.0259962011464233 NA NA NA hsa-miR-342-3p COBL -0.233020179388453 0.739959578456401 0.19682848427447 0.699601093424534 miRanda -0.2092424011884 0.0209761753045044 NA NA NA hsa-miR-766-3p COBL 0.103832486444169 0.839257506039953 0.19682848427447 0.699601093424534 MirTarget -0.302573851458854 2.39971603398625e-05 NA NA NA hsa-miR-107 COBLL1 -0.289737369453023 0.769655185893943 -0.227876576736832 0.612715681764406 PITA;miRanda;miRNATAP -0.179080606895637 0.0330854067409128 NA NA NA hsa-miR-107 COG6 -0.289737369453023 0.769655185893943 0.155097796557318 0.716915313848921 miRanda -0.131070078589402 0.00139585276934429 NA NA NA hsa-miR-222-3p COIL -0.233673471709747 0.726651775432807 0.260852168383174 0.531392480974126 miRNAWalker2_validate -0.114815318428268 7.14986499583995e-05 NA NA NA hsa-miR-129-5p COL10A1 0.417083435812871 0.454236109516901 1.20105478285569 0.0696393712158009 miRanda -0.461700993117299 3.22451268371142e-07 NA NA NA hsa-miR-335-3p COL10A1 0.0738544228922926 0.89349398283313 1.20105478285569 0.0696393712158009 mirMAP -0.324830698462883 0.003844801242913 NA NA NA hsa-miR-129-5p COL11A1 0.417083435812871 0.454236109516901 1.86049313442527 0.0240835818920053 PITA;miRanda;mirMAP;miRNATAP -0.377687492126654 0.00118765381710503 NA NA NA hsa-miR-141-3p COL11A1 -0.36932301319088 0.428364456128406 1.86049313442527 0.0240835818920053 miRNATAP -0.681082314947755 0.000166815820044067 NA NA NA hsa-miR-200a-3p COL11A1 -0.801422367541981 0.147987649395985 1.86049313442527 0.0240835818920053 miRNATAP -0.484461722791509 0.000706621009158583 NA NA NA hsa-miR-200c-5p COL11A1 -0.385629981568361 0.472280307737369 1.86049313442527 0.0240835818920053 MirTarget;miRNATAP -0.350330306224226 0.0186390122732487 NA NA NA hsa-miR-25-3p COL11A1 0.0681841609869576 0.955267320175687 1.86049313442527 0.0240835818920053 MirTarget -0.761904426800519 0.00260162134584663 NA NA NA hsa-miR-361-5p COL11A1 -0.278147578656315 0.728553069590798 1.86049313442527 0.0240835818920053 miRanda;miRNATAP -0.70275554765513 0.0171601762944866 NA NA NA hsa-miR-429 COL11A1 -0.596617415946644 0.128967410286089 1.86049313442527 0.0240835818920053 miRanda -0.317677026386336 0.0307683831210149 NA NA NA hsa-miR-92a-3p COL11A1 0.0155161307487504 0.991444817308063 1.86049313442527 0.0240835818920053 MirTarget -0.527660610796352 0.029691958501414 NA NA NA hsa-miR-92b-3p COL11A1 0.454620627632174 0.646193882241421 1.86049313442527 0.0240835818920053 MirTarget -0.358914828467555 0.0231524064627388 NA NA NA hsa-miR-106b-5p COL1A1 -0.3941595235172 0.389635342155994 0.655087630076235 0.552147709289232 mirMAP -0.388687051102425 0.00092249824388552 NA NA NA hsa-miR-129-5p COL1A1 0.417083435812871 0.454236109516901 0.655087630076235 0.552147709289232 miRanda -0.266680007475924 3.10925095052469e-05 NA NA NA hsa-miR-30a-3p COL1A1 0.11336767305191 0.920646436414994 0.655087630076235 0.552147709289232 mirMAP -0.200363502629268 0.0382450677485314 NA NA NA hsa-miR-30e-3p COL1A1 0.202355073367528 0.857417040078429 0.655087630076235 0.552147709289232 mirMAP -0.700760306983309 1.08482542382777e-07 NA NA NA hsa-miR-338-3p COL1A1 -0.107178830331044 0.818042702366464 0.655087630076235 0.552147709289232 miRanda;miRNATAP -0.198563309070392 0.00464685371307708 NA NA NA hsa-miR-93-5p COL1A1 -0.375078982324499 0.732311284477601 0.655087630076235 0.552147709289232 mirMAP -0.235314061723111 0.0362590342775392 NA NA NA hsa-miR-29c-3p COL21A1 0.042533372292219 0.941334605544826 0.245180586273906 0.578810643997086 miRNAWalker2_validate;miRTarBase -0.196177026817582 0.017688426718015 NA NA NA hsa-miR-29a-3p COL4A1 0.203872357562561 0.859946061784007 -0.0292183779176778 0.968023913485453 miRNAWalker2_validate;miRTarBase;miRNATAP -0.161357626237379 0.00145645824675615 NA NA NA hsa-miR-320c COL4A1 0.092255964601645 0.785539881268253 -0.0292183779176778 0.968023913485453 miRanda -0.10881920682706 0.0230926240506359 NA NA NA hsa-miR-99a-5p COL4A1 -0.3629378786679 0.683949996110801 -0.0292183779176778 0.968023913485453 miRNAWalker2_validate -0.116275142104441 0.00826689421614081 NA NA NA hsa-miR-107 COL5A1 -0.289737369453023 0.769655185893943 0.633294658705469 0.430856176814437 miRanda -0.273819910397762 0.0342935424161201 NA NA NA hsa-miR-129-5p COL5A2 0.417083435812871 0.454236109516901 0.780579565589767 0.262452024520043 miRanda -0.255665889895196 6.50580369916575e-05 NA NA NA hsa-miR-148a-5p COL5A2 -0.160202546137977 0.744679670526904 0.780579565589767 0.262452024520043 MirTarget -0.248202749113479 0.00599504807368822 NA NA NA hsa-miR-30a-3p COL5A2 0.11336767305191 0.920646436414994 0.780579565589767 0.262452024520043 mirMAP -0.267828019991002 0.00540545161538024 NA NA NA hsa-miR-30e-3p COL5A2 0.202355073367528 0.857417040078429 0.780579565589767 0.262452024520043 mirMAP -0.648097057647304 9.50933354612125e-07 NA NA NA hsa-miR-508-3p COL5A2 -1.03127992995769 0.311464814970261 0.780579565589767 0.262452024520043 MirTarget;PITA -0.263698640573641 4.20983035333322e-23 NA NA NA hsa-miR-885-5p COL5A2 -0.119561979753203 0.861296588445352 0.780579565589767 0.262452024520043 PITA;miRNATAP -0.133981387352168 0.00867248444324338 NA NA NA hsa-miR-15b-5p COPS7A 0.251826642099145 0.790709218602499 0.279590984725614 0.62772901217595 miRNATAP -0.143676093916562 0.000377366728411631 NA NA NA hsa-miR-125a-5p CORO1C -0.00666761469427968 0.994891296705929 -0.0355976463802383 0.949056132213283 miRNAWalker2_validate -0.135213551964633 0.010122912321249 NA NA NA hsa-miR-185-3p CORO2B -0.298032621542933 0.502557805985742 0.257996372316723 0.566936243313193 MirTarget -0.283924316704932 0.000955107851589781 NA NA NA hsa-miR-185-5p CORO2B -0.646398728237327 0.117918763555657 0.257996372316723 0.566936243313193 miRNAWalker2_validate;miRNATAP -0.230458327245057 0.00801559982685405 NA NA NA hsa-miR-330-5p CORO2B -0.152605584680815 0.787259112745893 0.257996372316723 0.566936243313193 MirTarget;miRanda;miRNATAP -0.241480336162573 0.0113671927757199 NA NA NA hsa-miR-362-5p CORO2B -0.35564884735017 0.452162806620853 0.257996372316723 0.566936243313193 PITA;TargetScan;miRNATAP -0.163789054523615 0.0108795376435489 NA NA NA hsa-miR-129-5p CP 0.417083435812871 0.454236109516901 0.321538002285332 0.705816054300037 miRanda -0.147601282395887 0.0250797135063993 NA NA NA hsa-miR-335-3p CP 0.0738544228922926 0.89349398283313 0.321538002285332 0.705816054300037 mirMAP -0.483980279762742 6.87746052523779e-10 NA NA NA hsa-miR-338-3p CP -0.107178830331044 0.818042702366464 0.321538002285332 0.705816054300037 miRanda -0.228341096187213 0.00136052985248629 NA NA NA hsa-miR-148b-3p CPA3 0.0855166854239631 0.914712779298241 1.55198096264427 0.0164161128307763 miRNAWalker2_validate -0.481604986651599 0.0378379514324693 NA NA NA hsa-let-7d-5p CPEB1 0.0119393569456978 0.988390093874148 -0.134882957782761 0.801746545624025 MirTarget;miRNATAP -0.334624344825876 0.0233295718469512 NA NA NA hsa-let-7f-5p CPEB1 -0.399676495198673 0.695365879077383 -0.134882957782761 0.801746545624025 MirTarget;miRNATAP -0.226235885853017 0.0285728175139823 NA NA NA hsa-let-7g-5p CPEB1 -0.320647530232065 0.660364346555039 -0.134882957782761 0.801746545624025 MirTarget;miRNATAP -0.3550851252689 0.00966360547351995 NA NA NA hsa-miR-101-3p CPEB1 -0.0149915187591869 0.981999725022451 -0.134882957782761 0.801746545624025 miRNATAP -0.340629661359267 0.013067578431131 NA NA NA hsa-miR-182-5p CPEB1 -0.262297863136789 0.8110070165759 -0.134882957782761 0.801746545624025 miRNATAP -0.318617935990031 0.000231606468708369 NA NA NA hsa-miR-183-5p CPEB1 -0.0462269171194745 0.969489414828393 -0.134882957782761 0.801746545624025 miRNATAP -0.259250424944377 0.00373513629308206 NA NA NA hsa-miR-429 CPEB1 -0.596617415946644 0.128967410286089 -0.134882957782761 0.801746545624025 miRNATAP -0.260204170754486 0.0110602489962932 NA NA NA hsa-miR-98-5p CPEB1 -0.0484028619275874 0.910781316485549 -0.134882957782761 0.801746545624025 MirTarget -0.238896648915318 0.0225111204935259 NA NA NA hsa-miR-214-3p CPNE4 0.0312810611346688 0.952640488671912 0.255052190280374 0.680227503645346 MirTarget -0.200707908555288 0.0430411886813004 NA NA NA hsa-miR-93-5p CRELD2 -0.375078982324499 0.732311284477601 0.0745537032846526 0.854515572251685 miRNAWalker2_validate -0.156974164652691 0.000931387832123533 NA NA NA hsa-miR-15b-5p CRIM1 0.251826642099145 0.790709218602499 0.202689844948188 0.72582221191569 MirTarget;miRNATAP -0.135014804859841 0.013425755484803 NA NA NA hsa-miR-129-5p CRISP3 0.417083435812871 0.454236109516901 0.621982113380244 0.485399208357808 miRanda -0.415952783234117 0.00247724278885932 NA NA NA hsa-miR-221-3p CROT -0.261179092929062 0.744019631321393 0.0401004909523413 0.905546632458772 miRNAWalker2_validate -0.109008910123131 0.00248559621737986 NA NA NA hsa-miR-140-3p CRTC1 -0.105651799466207 0.9077781740714 -0.220881928902426 0.668893180206995 mirMAP -0.101630612966372 0.0314105226839407 NA NA NA hsa-miR-125a-3p CRYL1 0.124026360619668 0.800539414590835 0.266674867007098 0.509699452828122 miRanda -0.324680858539582 2.63201299571552e-06 NA NA NA hsa-miR-296-5p CRYL1 0.194305256391454 0.752606409585409 0.266674867007098 0.509699452828122 MirTarget -0.10430187818943 0.00149093976151298 NA NA NA hsa-miR-320b CRYL1 0.298760649675195 0.700446828731538 0.266674867007098 0.509699452828122 miRanda -0.141876601126953 0.00239063817517261 NA NA NA hsa-miR-320d CRYL1 0.353471568894745 0.357430999251147 0.266674867007098 0.509699452828122 miRanda -0.11604452309516 0.00191096890295787 NA NA NA hsa-miR-186-5p CSNK2A1 -0.246324984406451 0.701310703524093 -0.0218617062443194 0.970823480302203 miRNAWalker2_validate;mirMAP;miRNATAP -0.152674194924329 0.000405936811333657 NA NA NA hsa-miR-330-5p CSRP1 -0.152605584680815 0.787259112745893 0.267445168156488 0.722828647901375 miRanda -0.151621860381497 0.00060775702159888 NA NA NA hsa-miR-140-3p CTAGE1 -0.105651799466207 0.9077781740714 0.0789414871360687 0.752189732704792 PITA -0.131686300919581 0.0260782605686816 NA NA NA hsa-miR-107 CTDSP1 -0.289737369453023 0.769655185893943 0.155653501582925 0.816578541803765 miRanda -0.131597406889972 0.000155862698880938 NA NA NA hsa-miR-106a-5p CTSA -0.820057689616516 0.0254490146664247 0.173391489357685 0.805175466975384 MirTarget -0.129857352705165 4.95863667634819e-07 NA NA NA hsa-miR-17-5p CTSA -0.643066792834501 0.320674049526638 0.173391489357685 0.805175466975384 miRNAWalker2_validate;MirTarget;TargetScan -0.109265669641623 0.000784868355857159 NA NA NA hsa-miR-128-3p CTU1 -0.0364518492233463 0.95841670253784 -0.191735767266881 0.631228156476905 MirTarget -0.127408567541442 0.00429731216067145 NA NA NA hsa-miR-22-3p CUL3 0.0468440219945929 0.967778504781139 -0.0233263194948385 0.966605304803416 miRNATAP -0.107787075359271 1.24554633466499e-06 NA NA NA hsa-miR-127-3p CXCL11 0.231539840651733 0.822108193638849 -0.573860008338374 0.31927067815559 miRanda -0.300346891095774 0.00117332838223155 NA NA NA hsa-miR-30c-1-3p CXCL2 0.140640717600046 0.633563796650597 0.00765601450050668 0.987754727872472 MirTarget -0.36727195362738 0.00157432925146208 NA NA NA hsa-miR-23a-3p CXorf57 0.174045248211037 0.865717934161724 0.244716127702479 0.633006750159916 miRNATAP -0.317040839482139 0.0252873917058053 NA NA NA hsa-miR-15b-5p CYB561D1 0.251826642099145 0.790709218602499 -0.424091767920599 0.28999065959536 mirMAP -0.11005254254516 0.0335142289196662 NA NA NA hsa-miR-330-3p CYB5A -0.1562229971038 0.692313620862782 0.07372399146701 0.879111631174972 miRNATAP -0.108554302003717 0.0204701069935211 NA NA NA hsa-miR-140-3p CYFIP2 -0.105651799466207 0.9077781740714 -0.0694467175468514 0.893116156849314 MirTarget -0.186154822189148 9.09417358912428e-05 NA NA NA hsa-miR-200b-3p CYP1B1 -0.532909690027328 0.555970111970307 0.307338067476794 0.566419033259287 TargetScan -0.147384871443846 0.0328959894783051 NA NA NA hsa-miR-200c-3p CYP1B1 -0.333638625701646 0.813830738880144 0.307338067476794 0.566419033259287 miRNATAP -0.271398607170222 0.000186060248633452 25860934 Loss of miR 200c up regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma; Additionally miR-200c which is significantly down-regulated in RCC regulates CYP1B1 expression and activity; An inverse association was also observed between the expression levels of miR-200c and CYP1B1 protein in RCC tissues; Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c; These results suggest that CYP1B1 up-regulation mediated by low miR-200c is one of the mechanisms underlying resistance of RCC cells to docetaxel; Therefore expression of CYP1B1 and miR-200c in RCC may be useful as a prediction for docetaxel response drug resistance kidney renal cell cancer hsa-miR-30a-3p CYP1B1 0.11336767305191 0.920646436414994 0.307338067476794 0.566419033259287 mirMAP -0.296806239534385 0.000235579905371352 NA NA NA hsa-miR-30e-3p CYP1B1 0.202355073367528 0.857417040078429 0.307338067476794 0.566419033259287 mirMAP -0.331977499232689 0.0032710083452041 NA NA NA hsa-miR-664a-3p CYP1B1 -0.139841943049965 0.800834383581795 0.307338067476794 0.566419033259287 mirMAP -0.237522112855553 0.0137462638485103 NA NA NA hsa-miR-15b-5p CYP26B1 0.251826642099145 0.790709218602499 0.442793458800653 0.306322577655703 MirTarget;miRNATAP -0.287765859555649 0.0286246327986535 NA NA NA hsa-miR-660-5p CYP26B1 -0.561687438133488 0.138270972367544 0.442793458800653 0.306322577655703 MirTarget -0.294995047535464 0.000186719627854617 NA NA NA hsa-miR-107 CYP2W1 -0.289737369453023 0.769655185893943 -0.728087559293801 0.281526537334884 mirMAP -0.424430296090525 0.0304739071991782 NA NA NA hsa-miR-106b-5p DAB2 -0.3941595235172 0.389635342155994 -0.0217591389095899 0.967485821345296 MirTarget;miRNATAP -0.120488909359049 0.0412553935395811 26769181 The expression of the miR-106b target gene DAB2 in human cervical tissues and cell lines were measured by qRT-PCR western blot and immunohistochemistry; DAB2 a predicted target gene of miR-106b was inhibited by TGF-β1 partly through miR-106b and was involved in TGF-β1-induced cervical cancer cell migration; The expression of DAB2 was low in cervical cancer tissues and negatively correlated with miR-106b expression cell migration cervical and endocervical cancer hsa-miR-30c-1-3p DAB2 0.140640717600046 0.633563796650597 -0.0217591389095899 0.967485821345296 MirTarget -0.141933736244045 0.00565335155928781 NA NA NA hsa-miR-22-3p DAD1 0.0468440219945929 0.967778504781139 0.0956804418908277 0.884983730532249 MirTarget -0.105123066940079 0.00206122522185403 NA NA NA hsa-let-7a-5p DARS2 0.0514604984725615 0.971564723582327 0.15499405565066 0.751776172832006 TargetScan -0.172682965217948 0.000116661287546511 NA NA NA hsa-miR-222-3p DARS2 -0.233673471709747 0.726651775432807 0.15499405565066 0.751776172832006 miRNAWalker2_validate -0.150086496769081 1.005726074731e-05 NA NA NA hsa-miR-30e-5p DBF4 -0.00273037859886571 0.997115479601006 -0.0943815270260968 0.796527323174908 MirTarget -0.116279391396644 0.00918698351434952 NA NA NA hsa-miR-186-5p DBN1 -0.246324984406451 0.701310703524093 -0.274431828268986 0.678578260564733 miRNAWalker2_validate;mirMAP -0.24511471315889 7.62117872059983e-07 NA NA NA hsa-miR-505-5p DBN1 -0.193966680796757 0.675835993908529 -0.274431828268986 0.678578260564733 miRNATAP -0.121819063073567 0.00608516548480478 NA NA NA hsa-miR-15b-5p DCAF8 0.251826642099145 0.790709218602499 0.0113853870067802 0.98535291263162 MirTarget -0.137010689315996 2.67880238367185e-05 NA NA NA hsa-miR-107 DCLK1 -0.289737369453023 0.769655185893943 0.0609744201620308 0.876725966427871 miRNATAP -0.282866854238758 0.0108019734968418 NA NA NA hsa-miR-181c-5p DCN -0.262596734125804 0.645471285705202 0.768017829762434 0.327293332462798 MirTarget -0.268903396323148 0.00127239032732601 NA NA NA hsa-miR-181d-5p DCN -0.294264170071504 0.604392929232074 0.768017829762434 0.327293332462798 MirTarget -0.193922302877424 0.00834585045806255 NA NA NA hsa-miR-139-5p DCP1B -0.0625698939687087 0.914810329989088 0.0103600492824336 0.981908008271292 miRanda -0.125923266495729 0.00029860625830053 NA NA NA hsa-miR-197-3p DDA1 0.0240027695773914 0.981971058073739 0.0316283766535514 0.95479668835842 mirMAP -0.133384955449802 0.00357379249434835 NA NA NA hsa-miR-140-3p DDN -0.105651799466207 0.9077781740714 -0.174843853505509 0.664607630428512 miRNATAP -0.199942188355298 0.0428896791796713 NA NA NA hsa-miR-221-3p DDX52 -0.261179092929062 0.744019631321393 -0.119482824633703 0.77617610112782 mirMAP -0.164298905911958 5.66570850071214e-08 NA NA NA hsa-miR-15b-5p DEF8 0.251826642099145 0.790709218602499 -0.0760343822266334 0.86496372074907 MirTarget -0.193448097344469 7.63737855367691e-07 NA NA NA hsa-miR-221-3p DENR -0.261179092929062 0.744019631321393 -0.0498635076185616 0.927370593731145 miRNAWalker2_validate -0.12289100547636 1.75375810558281e-06 NA NA NA hsa-miR-135b-5p DEPDC1 -0.23385744223922 0.533765059244218 -0.296566456214355 0.509435122457728 MirTarget -0.1669344132046 0.000269978957833263 NA NA NA hsa-miR-26a-5p DEPDC1 0.0483232931294246 0.955218190818435 -0.296566456214355 0.509435122457728 MirTarget -0.376059321649114 5.72454949458256e-06 NA NA NA hsa-miR-664a-3p DEPDC1 -0.139841943049965 0.800834383581795 -0.296566456214355 0.509435122457728 MirTarget -0.399640236513845 4.5307561787172e-09 NA NA NA hsa-miR-532-3p DES 0.102082509259256 0.893896651717717 0.522946115879641 0.334436094588935 PITA;miRNATAP -0.239021178343512 0.0159039780947008 NA NA NA hsa-miR-125b-5p DGAT1 0.0074438975183444 0.994154663318355 0.209076970912306 0.722440295573126 miRNAWalker2_validate;miRTarBase -0.185672703009567 4.80341232956402e-05 NA NA NA hsa-miR-423-5p DGAT1 -0.314923545892784 0.658894400879422 0.209076970912306 0.722440295573126 miRNATAP -0.186019782524707 0.00354129149551554 NA NA NA hsa-miR-107 DGCR6 -0.289737369453023 0.769655185893943 -0.0423463663895833 0.903982750653816 miRanda -0.137272693170997 0.0271638500541659 NA NA NA hsa-miR-107 DGCR6L -0.289737369453023 0.769655185893943 -0.0868968423144798 0.853879559550046 miRanda -0.103423309599828 0.0372827716098917 NA NA NA hsa-miR-15b-5p DGKD 0.251826642099145 0.790709218602499 -0.387051615675522 0.325412186035661 mirMAP -0.130972667778844 0.00490883986866329 NA NA NA hsa-miR-125a-5p DHFR -0.00666761469427968 0.994891296705929 -0.0956460229193841 0.813063819463935 miRanda -0.35521266489401 3.51563939250165e-05 NA NA NA hsa-miR-664a-3p DHFR -0.139841943049965 0.800834383581795 -0.0956460229193841 0.813063819463935 mirMAP -0.145536203268112 0.011262059923527 NA NA NA hsa-miR-107 DHRS12 -0.289737369453023 0.769655185893943 0.215342568728848 0.490845225963659 miRanda -0.127671758154227 0.0145984448443517 NA NA NA hsa-miR-107 DHRS4L2 -0.289737369453023 0.769655185893943 -0.286415076580927 0.429347432484529 miRanda -0.325066583601412 0.000554709611340471 NA NA NA hsa-miR-125a-3p DHRS7B 0.124026360619668 0.800539414590835 0.250439864922392 0.532212227206337 MirTarget;miRanda -0.142246089530715 0.0022115932514142 NA NA NA hsa-miR-92a-3p DHRS7B 0.0155161307487504 0.991444817308063 0.250439864922392 0.532212227206337 miRNAWalker2_validate -0.106668959771667 0.0174321590269619 NA NA NA hsa-miR-107 DIP2C -0.289737369453023 0.769655185893943 0.0241787666113469 0.95634520880725 miRanda -0.199355080837331 0.0032009908877288 NA NA NA hsa-miR-221-3p DIRAS3 -0.261179092929062 0.744019631321393 0.138022680891339 0.721265087543955 miRTarBase -0.180865963233304 0.0304218132177821 21071579;23801152;22117988 Further studies on a new mechanism of ARHI downregulation showed a significant inverse relationship between ARHI and miR-221 and 222 which were upregulated in prostate cancer cell lines; Transfection of miR-221 and 222 inhibitors into PC-3 cells caused a significant induction of ARHI expression; A direct interaction of miR-221 or 222 with a target site on the 3'UTR of ARHI was confirmed by a dual luciferase pMIR-REPORT assay; Finally we also found that genistein upregulates ARHI by downregulating miR-221 and 222 in PC-3 cells;Effects of ARHI on breast cancer cell biological behavior regulated by microRNA 221; The downregulation of ARHI was regulated by miR-221 in prostate cancer cell lines; However it has not been reported whether ARHI is regulated by miR-221 in breast cancer; To address whether ARHI is regulated by miR-221 in breast cancer cell lines the results in this study showed that a significant inverse correlation existed between ARHI and miR-221; The inhibition of miR-221 induced a significant upregulation of ARHI in MCF-7 cells; To prove a direct interaction between miR-221 and ARHI mRNA ARHI 3'UTR which includes the potential target site for miR-221 was cloned downstream of the luciferase reporter gene of the pMIR-REPORT vector to generate the pMIR-ARHI-3'UTR vector; The results confirmed a direct interaction of miR-221 with a target site on the 3'UTR of ARHI; This study demonstrated for the first time that the downregulation of ARHI in breast cancer cells could be regulated by miR-221;MicroRNA 221 and 222 have been shown to regulate ARHI expression negatively; Expression of ARHI and microRNA 221 and 222 was measured by real-time reverse transcription-polymerase chain reaction; Whether ARHI and microRNA 221 and 222 could be considered as biomarkers for disease progression in prostate cancer requires further investigation ;;progression prostate cancer;breast cancer;prostate cancer hsa-miR-222-3p DIRAS3 -0.233673471709747 0.726651775432807 0.138022680891339 0.721265087543955 miRTarBase -0.169117626559432 0.0414469096710404 NA NA NA hsa-miR-15b-5p DIXDC1 0.251826642099145 0.790709218602499 0.278415039341975 0.465273271597506 MirTarget -0.163985406740794 0.00259574760551469 NA NA NA hsa-miR-16-5p DIXDC1 -0.199225750365017 0.742834324195084 0.278415039341975 0.465273271597506 miRNAWalker2_validate;MirTarget -0.126162250940492 0.00503050052099507 NA NA NA hsa-miR-186-5p DIXDC1 -0.246324984406451 0.701310703524093 0.278415039341975 0.465273271597506 mirMAP -0.135808482291498 0.0148928978356472 NA NA NA hsa-miR-200b-3p DIXDC1 -0.532909690027328 0.555970111970307 0.278415039341975 0.465273271597506 MirTarget;TargetScan -0.110478950148479 0.00131411020529169 NA NA NA hsa-miR-200c-3p DIXDC1 -0.333638625701646 0.813830738880144 0.278415039341975 0.465273271597506 MirTarget -0.101153555241003 0.00561327825613644 NA NA NA hsa-miR-28-5p DIXDC1 -0.0511712157419266 0.910958192291954 0.278415039341975 0.465273271597506 miRanda -0.108839593944627 0.0452520417693066 NA NA NA hsa-miR-342-3p DIXDC1 -0.233020179388453 0.739959578456401 0.278415039341975 0.465273271597506 PITA;miRanda -0.216851439696066 9.79604831444865e-06 NA NA NA hsa-miR-107 DKK1 -0.289737369453023 0.769655185893943 1.00397863183292 0.12946363104636 miRanda -0.662019048090974 0.000357369434070963 NA NA NA hsa-miR-326 DLEC1 0.307641210889423 0.653580115931293 -0.6372229945319 0.139803762119508 miRanda -0.2675879858465 0.00065194980059459 NA NA NA hsa-miR-330-5p DLEC1 -0.152605584680815 0.787259112745893 -0.6372229945319 0.139803762119508 miRanda -0.338846506680885 0.00266250166685162 NA NA NA hsa-miR-107 DLEU1 -0.289737369453023 0.769655185893943 0.539705499129087 0.045364145911034 miRanda -0.155997483971692 0.00805222397665356 NA NA NA hsa-miR-148a-3p DLG2 -0.324144803192141 0.746264759480212 0.379533315306163 0.304081069740784 MirTarget;miRNATAP -0.195476986276403 0.0242885834699011 NA NA NA hsa-miR-363-3p DLG2 -0.186046567396088 0.728622856049059 0.379533315306163 0.304081069740784 mirMAP -0.111371790934155 0.0339661981784351 NA NA NA hsa-miR-15b-5p DLL1 0.251826642099145 0.790709218602499 0.294788113590102 0.411069437919416 miRNATAP -0.411601755454137 7.51525341204853e-05 NA NA NA hsa-miR-15b-5p DLL4 0.251826642099145 0.790709218602499 -0.368602479212739 0.229619555752877 miRNATAP -0.16890286930773 0.00108435920887059 NA NA NA hsa-miR-107 DMRT2 -0.289737369453023 0.769655185893943 0.0280023824536557 0.967149688369316 miRanda -0.475946716856519 0.00669020102671467 NA NA NA hsa-miR-221-3p DMRT3 -0.261179092929062 0.744019631321393 0.345688354953898 0.606960717050321 MirTarget;miRNATAP -0.36255103394903 0.016438922476834 NA NA NA hsa-miR-222-3p DMRT3 -0.233673471709747 0.726651775432807 0.345688354953898 0.606960717050321 MirTarget;miRNATAP -0.446743754057431 0.00281106543453172 NA NA NA hsa-miR-222-3p DMWD -0.233673471709747 0.726651775432807 -0.121687291649838 0.818294458768291 miRNAWalker2_validate -0.108425005948701 0.000699836210909241 NA NA NA hsa-miR-1228-3p DNAH3 0.424741903668811 0.216444756721484 -0.188861790952452 0.61448312484152 mirMAP -0.185577674928078 0.0119129665941872 NA NA NA hsa-miR-199a-5p DNAH7 0.248253058498817 0.7461266806999 -0.369234192385844 0.318877998992386 miRanda -0.149738143159729 0.018404886241087 NA NA NA hsa-miR-342-3p DNAH9 -0.233020179388453 0.739959578456401 -0.569624777861681 0.323202780461592 miRanda -0.390802765861227 0.0161891413558483 NA NA NA hsa-miR-330-5p DNAI2 -0.152605584680815 0.787259112745893 -0.406805086949501 0.613945534647062 miRanda -0.469126959874602 0.0114073286764479 NA NA NA hsa-miR-22-3p DNAJC27 0.0468440219945929 0.967778504781139 -0.106141068710585 0.698089779114498 MirTarget -0.112311411407639 8.39914262174449e-05 NA NA NA hsa-miR-27a-3p DNAJC27 0.309634509674364 0.703724209648479 -0.106141068710585 0.698089779114498 miRNAWalker2_validate;MirTarget;miRNATAP -0.128902899055301 7.08370136190131e-05 NA NA NA hsa-miR-107 DNAJC3 -0.289737369453023 0.769655185893943 0.0529396133010049 0.918145162613122 miRanda -0.135432508512196 0.000507518375490281 NA NA NA hsa-let-7f-1-3p DNALI1 0.131753980154284 0.686438107181988 0.51452984265938 0.389484336947314 MirTarget -0.354195806958699 0.000516381024889281 NA NA NA hsa-miR-27a-5p DNALI1 -0.00797189811576748 0.985270279280688 0.51452984265938 0.389484336947314 MirTarget;miRNATAP -0.178033001758983 0.0398508832011463 NA NA NA hsa-let-7b-5p DNMBP 0.396604576702067 0.783406687058469 0.306972852983297 0.464300345987425 miRNAWalker2_validate -0.138060341569133 0.0129532979882693 NA NA NA hsa-miR-224-5p DNMBP -0.143123534787342 0.827443367193551 0.306972852983297 0.464300345987425 MirTarget -0.100760206794065 0.000358348686436117 NA NA NA hsa-miR-29a-3p DNMT3B 0.203872357562561 0.859946061784007 -0.154275185056994 0.690451099020331 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.311221745974643 1.39847290369651e-09 22479643;23939044;23789939 The miR-29 family and predicted target genes were among the most strongly anti-correlated miRNA:mRNA pairs; over-expression of miR-29a in vitro repressed several anti-correlated genes including DNMT3A and DNMT3B and substantially decreased ovarian cancer cell viability;The miR-29 family miR-29a -29b and -29c which negatively regulates DNMT3A and DNMT3B was examined in association with the Wnt/β-catenin signaling pathway; The expression of miR-29a and miR-29b was partially regulated by DNMT3A and DNMT3B in a positive feedback loop;TGF-β increased DNMT3B and DNMT1 and decreased miR-29a expression ;; ovarian cancer;lung squamous cell cancer;liver cancer hsa-miR-29b-3p DNMT3B -0.249746665931503 0.558208927436524 -0.154275185056994 0.690451099020331 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.116516293934253 0.00173749663987323 22479643;23939044;26404322 The miR-29 family and predicted target genes were among the most strongly anti-correlated miRNA:mRNA pairs; over-expression of miR-29a in vitro repressed several anti-correlated genes including DNMT3A and DNMT3B and substantially decreased ovarian cancer cell viability;The miR-29 family miR-29a -29b and -29c which negatively regulates DNMT3A and DNMT3B was examined in association with the Wnt/β-catenin signaling pathway; The expression of miR-29a and miR-29b was partially regulated by DNMT3A and DNMT3B in a positive feedback loop;The induction of miR-29b was accompanied with suppression of its downstream target DNMT3B in a dose-dependent manner; The reduction of luciferase activity of DNMT3B 3'-UTR reporter by fucoidan was as markedly as that by miR-29b mimic indicating that fucoidan induced miR-29b to suppress DNMT3B ;; ovarian cancer;lung squamous cell cancer;liver cancer hsa-miR-148a-3p DOCK3 -0.324144803192141 0.746264759480212 -0.0166222052716001 0.967344829404864 miRNATAP -0.237555781947253 0.00691554229344623 NA NA NA hsa-miR-140-3p DOK5 -0.105651799466207 0.9077781740714 0.535561087648704 0.38576876834976 miRNATAP -0.258284640582259 0.0210282121919744 NA NA NA hsa-miR-22-3p DPF2 0.0468440219945929 0.967778504781139 0.00237745456848337 0.996715690436653 MirTarget;miRNATAP -0.106303351689186 2.08017784703879e-06 NA NA NA hsa-miR-1266-5p DPT 0.193428002960802 0.749720354543557 1.25254050214135 0.0518254661462424 MirTarget -0.332325091680396 0.0238934226167007 NA NA NA hsa-miR-148b-3p DPT 0.0855166854239631 0.914712779298241 1.25254050214135 0.0518254661462424 miRNAWalker2_validate -1.00939811323509 1.3428253413966e-05 NA NA NA hsa-miR-17-3p DPT -0.13137566263129 0.849946548607015 1.25254050214135 0.0518254661462424 MirTarget -0.500732444124613 0.00349119284912344 NA NA NA hsa-miR-361-5p DPT -0.278147578656315 0.728553069590798 1.25254050214135 0.0518254661462424 miRanda -0.702906123637833 0.00497411955321366 NA NA NA hsa-miR-429 DPT -0.596617415946644 0.128967410286089 1.25254050214135 0.0518254661462424 miRNATAP -0.407824059939324 0.00104445277776195 NA NA NA hsa-miR-221-3p DPY19L3 -0.261179092929062 0.744019631321393 -0.15393983102763 0.707347494933269 MirTarget -0.118287187589827 0.00616241381527742 NA NA NA hsa-miR-222-3p DPY19L3 -0.233673471709747 0.726651775432807 -0.15393983102763 0.707347494933269 MirTarget -0.171956882029169 5.25570545609581e-05 NA NA NA hsa-miR-22-3p DPY30 0.0468440219945929 0.967778504781139 0.425705805428714 0.419534780417793 MirTarget -0.131887431399372 0.000107622916648275 NA NA NA hsa-miR-106b-5p DPYD -0.3941595235172 0.389635342155994 0.0935905458567876 0.835372796590441 MirTarget -0.310433899198511 0.000529682571676397 NA NA NA hsa-miR-129-5p DPYD 0.417083435812871 0.454236109516901 0.0935905458567876 0.835372796590441 miRanda -0.174060500541327 0.000396380861804775 NA NA NA hsa-miR-335-3p DPYD 0.0738544228922926 0.89349398283313 0.0935905458567876 0.835372796590441 MirTarget;mirMAP -0.277685663931842 3.32014818473307e-06 NA NA NA hsa-miR-338-3p DPYD -0.107178830331044 0.818042702366464 0.0935905458567876 0.835372796590441 miRanda -0.128132306887811 0.0170760338554265 NA NA NA hsa-miR-93-5p DPYD -0.375078982324499 0.732311284477601 0.0935905458567876 0.835372796590441 MirTarget -0.223913891259384 0.00898616961991519 NA NA NA hsa-miR-150-5p DPYSL5 -0.00683324482969283 0.994067057151257 -0.557022998839057 0.510670233026649 mirMAP -0.689793705712692 1.90875584455956e-09 NA NA NA hsa-miR-129-5p DSC2 0.417083435812871 0.454236109516901 0.0536060366685467 0.93234953250075 miRanda -0.101634737892045 0.0333133739513107 NA NA NA hsa-miR-363-3p DSC2 -0.186046567396088 0.728622856049059 0.0536060366685467 0.93234953250075 MirTarget -0.135353689613998 0.00224105568684905 NA NA NA hsa-miR-107 DSE -0.289737369453023 0.769655185893943 -0.0253357981342237 0.953678264673674 miRanda -0.101671171462872 0.0424726688525274 NA NA NA hsa-miR-107 DSEL -0.289737369453023 0.769655185893943 0.388931488895636 0.371345885950686 miRanda;miRNATAP -0.220592333523524 0.0304342909435194 NA NA NA hsa-miR-141-3p DTL -0.36932301319088 0.428364456128406 -0.0908285224961372 0.815576129815931 MirTarget -0.12748593201888 0.00335709911336703 NA NA NA hsa-miR-664a-3p DTL -0.139841943049965 0.800834383581795 -0.0908285224961372 0.815576129815931 mirMAP -0.159698879710712 0.00121813021008669 NA NA NA hsa-miR-221-3p DTNA -0.261179092929062 0.744019631321393 0.079919244724207 0.86913793101396 mirMAP -0.463183940957271 4.39416012311961e-06 NA NA NA hsa-miR-125a-5p DUOX1 -0.00666761469427968 0.994891296705929 0.431560744768506 0.338606951128513 miRanda -0.379228894974554 0.0221809707656808 NA NA NA hsa-miR-107 DUSP7 -0.289737369453023 0.769655185893943 -0.133353800652199 0.776194243532699 miRanda -0.104027687146737 0.0222405184566961 NA NA NA hsa-miR-221-3p DVL2 -0.261179092929062 0.744019631321393 -0.322024825039206 0.507327359550734 miRNAWalker2_validate -0.111635424047559 0.000236771884706682 21487968 MiR 221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2; We also suggest that miR-221 may control the migration of AIPC cells through DVL2 working as a key regulator in advanced CaP staging prostate cancer hsa-miR-15b-5p DYNC1LI2 0.251826642099145 0.790709218602499 -0.00723049691089805 0.989825607150571 MirTarget;miRNATAP -0.112177184617386 0.00209186637554562 NA NA NA hsa-miR-155-5p DYNC2H1 -0.320577372003167 0.673183036961734 0.443301516669433 0.222362027445187 miRNAWalker2_validate -0.109854846595319 0.0106891360230463 NA NA NA hsa-miR-342-3p DYNC2H1 -0.233020179388453 0.739959578456401 0.443301516669433 0.222362027445187 miRanda -0.380643333319166 2.94232719878606e-10 NA NA NA hsa-miR-27a-3p DYNC2LI1 0.309634509674364 0.703724209648479 0.330194449344121 0.37937835445585 MirTarget -0.132214047616589 0.00050861931973541 NA NA NA hsa-miR-148a-3p DYRK1B -0.324144803192141 0.746264759480212 0.0459132310244739 0.93769857295231 miRNATAP -0.112400879290334 0.0135409264614976 NA NA NA hsa-miR-15b-5p DYRK1B 0.251826642099145 0.790709218602499 0.0459132310244739 0.93769857295231 MirTarget;miRNATAP -0.137689626174516 0.0203589463044507 NA NA NA hsa-miR-214-3p E2F2 0.0312810611346688 0.952640488671912 -0.30036161792182 0.441465433449537 mirMAP -0.100978493662983 0.0046131021749937 NA NA NA hsa-let-7b-5p E2F3 0.396604576702067 0.783406687058469 -0.404508205136487 0.372452040623511 miRNAWalker2_validate -0.141976016531904 1.65654919080495e-05 NA NA NA hsa-miR-320a E2F3 0.142884703798297 0.888511174254355 -0.404508205136487 0.372452040623511 PITA;miRanda;miRNATAP -0.10463869856316 0.00608122157535555 NA NA NA hsa-miR-107 EBF1 -0.289737369453023 0.769655185893943 0.361862231860407 0.312712520874324 MirTarget;miRanda;miRNATAP -0.318824950995242 0.000523012627428682 NA NA NA hsa-miR-30e-3p ECM2 0.202355073367528 0.857417040078429 0.418589222486879 0.274144163925336 MirTarget -0.359082145794789 0.000229472849655901 NA NA NA hsa-miR-331-5p ECM2 -0.158202371972628 0.561893260130397 0.418589222486879 0.274144163925336 MirTarget -0.203908797279049 0.0194474531365249 NA NA NA hsa-miR-335-3p ECM2 0.0738544228922926 0.89349398283313 0.418589222486879 0.274144163925336 MirTarget -0.124091050607144 0.0319469437230178 NA NA NA hsa-miR-26b-5p ECT2 0.16143906971203 0.790777916193478 -0.221806590292264 0.694293766142819 miRNAWalker2_validate -0.187030178794868 0.0038379795954617 NA NA NA hsa-miR-664a-3p ECT2 -0.139841943049965 0.800834383581795 -0.221806590292264 0.694293766142819 MirTarget;mirMAP -0.363762907244051 3.5664370954381e-12 NA NA NA hsa-miR-15b-5p EDA 0.251826642099145 0.790709218602499 0.335623537399135 0.409639164424153 MirTarget;miRNATAP -0.223990895126348 0.012939550092097 NA NA NA hsa-miR-15b-5p EEF1A1 0.251826642099145 0.790709218602499 0.124313898206736 0.906661592315232 miRNAWalker2_validate -0.207136546751281 8.59455395884229e-05 NA NA NA hsa-miR-197-3p EEF1A1 0.0240027695773914 0.981971058073739 0.124313898206736 0.906661592315232 miRNAWalker2_validate -0.182339823398992 0.000697730486362661 NA NA NA hsa-miR-107 EEF1A1P9 -0.289737369453023 0.769655185893943 0.241325839653457 0.490518791484523 miRanda -0.174690040355524 0.00362869322634614 NA NA NA hsa-miR-326 EFCAB6 0.307641210889423 0.653580115931293 0.0651855122555561 0.823504597062235 miRanda -0.102059908359307 0.0479220340595781 NA NA NA hsa-miR-330-5p EFCAB6 -0.152605584680815 0.787259112745893 0.0651855122555561 0.823504597062235 miRanda -0.268922376416564 0.000246996163132451 NA NA NA hsa-miR-128-3p EFEMP2 -0.0364518492233463 0.95841670253784 0.0846998523046159 0.888255700310019 miRNAWalker2_validate -0.137476747480702 0.0399610281219129 NA NA NA hsa-miR-342-3p EFHC1 -0.233020179388453 0.739959578456401 0.0154074292168751 0.970734997873558 miRanda -0.214194835979905 8.27127613380994e-05 NA NA NA hsa-miR-199a-5p EFHC2 0.248253058498817 0.7461266806999 -0.0507162563198691 0.892298591640867 miRanda -0.16431796102856 0.00605638333329291 NA NA NA hsa-miR-199b-5p EFHC2 0.415198317247236 0.324258779965011 -0.0507162563198691 0.892298591640867 miRanda -0.109318524426982 0.0479396592053676 NA NA NA hsa-miR-664a-5p EFHD1 -0.19612479730604 0.558657187130445 0.00793734821198155 0.987778058955427 MirTarget -0.172577335751588 0.0372562887205296 NA NA NA hsa-miR-27a-3p EFNA3 0.309634509674364 0.703724209648479 -0.237029528793301 0.535270655381165 miRNATAP -0.19042285448469 0.00164122510965065 NA NA NA hsa-miR-26b-5p EFNA4 0.16143906971203 0.790777916193478 -0.0990476518785766 0.807827823062464 miRNAWalker2_validate -0.198409098982162 0.00026837109310179 NA NA NA hsa-miR-361-3p EFNA4 -0.398826925662302 0.617283381786186 -0.0990476518785766 0.807827823062464 MirTarget;miRNATAP -0.225552644596369 7.7511390339383e-06 NA NA NA hsa-miR-107 EFNB2 -0.289737369453023 0.769655185893943 -0.0415462898228647 0.945513003886044 miRNATAP -0.204808266760602 0.0137120455190931 NA NA NA hsa-miR-148a-3p EFNB2 -0.324144803192141 0.746264759480212 -0.0415462898228647 0.945513003886044 MirTarget;miRNATAP -0.233116661217732 0.000381087741100227 NA NA NA hsa-miR-22-3p EFR3B 0.0468440219945929 0.967778504781139 -0.184292387875329 0.600415783873846 MirTarget -0.242660001442657 0.00133319399287846 NA NA NA hsa-let-7a-3p EGFL6 0.0395190175369595 0.888702137550015 0.57307484450463 0.263623808228204 MirTarget -0.188648859562315 0.021385424644226 NA NA NA hsa-let-7b-3p EGFL6 0.314328399485033 0.684245834514538 0.57307484450463 0.263623808228204 MirTarget -0.208876624748628 0.0200654710883385 NA NA NA hsa-miR-363-3p EGR2 -0.186046567396088 0.728622856049059 0.093736233681752 0.83352480815983 miRNATAP -0.130934732471141 0.00664271614169299 NA NA NA hsa-miR-107 EIF1AX -0.289737369453023 0.769655185893943 0.0463635789388031 0.934275108186525 miRanda -0.15414251796644 0.000889825657424266 NA NA NA hsa-miR-139-5p EIF4A2 -0.0625698939687087 0.914810329989088 0.047295053456212 0.953001307888256 miRanda -0.104169938267191 0.00148368929612165 NA NA NA hsa-miR-15b-5p EIF4B 0.251826642099145 0.790709218602499 0.253724736012796 0.731289892164022 miRNATAP -0.115010477791509 0.00682931396021433 NA NA NA hsa-miR-125a-5p EIF4EBP1 -0.00666761469427968 0.994891296705929 -0.208386773710733 0.691910342787463 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.262782588410493 0.00150590800615567 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ovarian cancer hsa-miR-148a-3p ELFN2 -0.324144803192141 0.746264759480212 0.698277547717831 0.2354082698908 mirMAP -0.462369570862637 0.000774539993007686 NA NA NA hsa-miR-15b-5p ELFN2 0.251826642099145 0.790709218602499 0.698277547717831 0.2354082698908 mirMAP -0.399268266584176 0.0267343403631748 NA NA NA hsa-miR-130a-3p EMCN -0.0153771286384572 0.977389403395331 0.621067118910975 0.0358083973048065 mirMAP -0.170306077239816 0.00468262061929034 NA NA NA hsa-miR-194-5p EMCN -0.141051051043955 0.809072276924359 0.621067118910975 0.0358083973048065 MirTarget -0.152788034899527 0.000585408910037542 NA NA NA hsa-miR-148a-3p EMX2 -0.324144803192141 0.746264759480212 0.486817038715191 0.511999379831851 miRNATAP -0.529429825732203 1.71387766081361e-06 NA NA NA hsa-miR-18a-3p ENC1 -0.188202012159778 0.618004963641688 -0.240047843217205 0.678841082149898 MirTarget;miRNATAP -0.163132745970091 0.0190786986758122 NA NA NA hsa-miR-192-5p ENC1 -0.00281508349767456 0.99638352116085 -0.240047843217205 0.678841082149898 miRNAWalker2_validate -0.105974321288086 0.0429824584718803 NA NA NA hsa-miR-26b-5p ENC1 0.16143906971203 0.790777916193478 -0.240047843217205 0.678841082149898 mirMAP;miRNATAP -0.185735521010482 0.0409224185013319 NA NA NA hsa-miR-28-3p ENC1 0.0964925270967019 0.928391906694323 -0.240047843217205 0.678841082149898 MirTarget;PITA;miRNATAP -0.232660313234192 0.0252079095631189 NA NA NA hsa-miR-339-5p ENC1 -0.121565674268033 0.81427862647099 -0.240047843217205 0.678841082149898 MirTarget;miRanda -0.144173646431411 0.0460734447795229 NA NA NA hsa-miR-505-5p ENC1 -0.193966680796757 0.675835993908529 -0.240047843217205 0.678841082149898 miRNAWalker2_validate -0.163052233784511 0.0356466467456392 NA NA NA hsa-miR-107 ENPP1 -0.289737369453023 0.769655185893943 0.738380987953416 0.0958167664835978 miRanda -0.213938006794429 0.0305819189489463 NA NA NA hsa-miR-107 ENTPD3 -0.289737369453023 0.769655185893943 0.615566915436617 0.14444270939096 miRanda -0.354948814562702 0.00232742825830551 NA NA NA hsa-miR-222-3p ENTPD7 -0.233673471709747 0.726651775432807 0.198648540058904 0.60002263716959 MirTarget -0.116921280494716 0.00687411641040975 NA NA NA hsa-miR-222-3p EPB41L2 -0.233673471709747 0.726651775432807 0.399473445231796 0.492457153760958 miRNAWalker2_validate -0.115160288680846 0.0329256117845677 NA NA NA hsa-miR-181c-5p EPB41L3 -0.262596734125804 0.645471285705202 0.137709162603401 0.74747709064158 MirTarget -0.181142786594217 0.00364750095542005 NA NA NA hsa-miR-181d-5p EPB41L3 -0.294264170071504 0.604392929232074 0.137709162603401 0.74747709064158 MirTarget -0.136781857244346 0.012614481437861 NA NA NA hsa-miR-184 EPB41L3 -0.348262337174389 0.472209661668959 0.137709162603401 0.74747709064158 PITA;miRanda -0.149733779134035 0.000276648070865691 NA NA NA hsa-miR-92a-3p EPB41L3 0.0155161307487504 0.991444817308063 0.137709162603401 0.74747709064158 miRNAWalker2_validate -0.311117165242427 0.000767589285070081 NA NA NA hsa-miR-16-5p EPB41L4B -0.199225750365017 0.742834324195084 -0.0254106034172406 0.954466237218683 MirTarget;miRNATAP -0.113469970977549 0.0366590524784309 NA NA NA hsa-miR-26a-5p EPB41L4B 0.0483232931294246 0.955218190818435 -0.0254106034172406 0.954466237218683 miRNATAP -0.169297661087152 0.0152717080841697 NA NA NA hsa-miR-497-5p EPB41L4B -0.345178187351251 0.463288640782623 -0.0254106034172406 0.954466237218683 MirTarget;miRNATAP -0.100745427505195 0.0204959133598246 NA NA NA hsa-miR-29a-3p EPHB3 0.203872357562561 0.859946061784007 -0.281194166633176 0.63777668272651 miRNATAP -0.224042215794144 0.00496579059145623 NA NA NA hsa-miR-29b-3p EPHB3 -0.249746665931503 0.558208927436524 -0.281194166633176 0.63777668272651 miRNATAP -0.15200049723953 0.00709208940328803 NA NA NA hsa-miR-29c-3p EPHB3 0.042533372292219 0.941334605544826 -0.281194166633176 0.63777668272651 miRNATAP -0.164391908540862 0.0114819414645612 NA NA NA hsa-miR-107 EPHX2 -0.289737369453023 0.769655185893943 -0.0525148582659218 0.900063122006352 miRanda -0.155591107022651 0.023755081091922 NA NA NA hsa-miR-324-5p EPHX2 -0.358991607952497 0.499732551112182 -0.0525148582659218 0.900063122006352 miRanda -0.198907002860481 0.000997546518437117 NA NA NA hsa-miR-326 EPHX2 0.307641210889423 0.653580115931293 -0.0525148582659218 0.900063122006352 MirTarget;miRanda -0.163068806609238 9.12824595946412e-05 NA NA NA hsa-miR-330-5p EPHX2 -0.152605584680815 0.787259112745893 -0.0525148582659218 0.900063122006352 MirTarget;miRanda -0.243948856476864 4.35991705417774e-05 NA NA NA hsa-miR-769-3p EPHX2 0.0256482406355687 0.939929956150103 -0.0525148582659218 0.900063122006352 MirTarget -0.155358342870905 0.00779437291408971 NA NA NA hsa-miR-140-3p EPM2AIP1 -0.105651799466207 0.9077781740714 -0.00623458917157027 0.990693948217373 MirTarget -0.110094774910385 0.00704010191535803 NA NA NA hsa-miR-15b-5p ERC2 0.251826642099145 0.790709218602499 0.228089427804528 0.438720877351793 MirTarget;miRNATAP -0.270326749936933 0.00224466181938416 NA NA NA hsa-miR-128-3p ERCC1 -0.0364518492233463 0.95841670253784 0.160493405574076 0.764840131436112 MirTarget -0.121177396109685 0.00968007948093491 NA NA NA hsa-miR-107 ERCC2 -0.289737369453023 0.769655185893943 0.00628532654217473 0.988700388974902 mirMAP -0.19976779325921 1.42195423554797e-05 NA NA NA hsa-miR-222-3p ERCC6L -0.233673471709747 0.726651775432807 -0.217089858470344 0.493189494636312 miRNAWalker2_validate -0.115323184306931 0.0221859407300288 NA NA NA hsa-miR-107 ERG -0.289737369453023 0.769655185893943 0.0326386813167203 0.921192161731388 miRanda -0.169944809788539 0.00838342819654601 NA NA NA hsa-miR-15b-3p ERLIN2 0.0805005446828257 0.846317514546419 0.0155537175380891 0.977253393227077 mirMAP -0.164204426945093 7.21582203707003e-05 NA NA NA hsa-miR-16-5p ERLIN2 -0.199225750365017 0.742834324195084 0.0155537175380891 0.977253393227077 miRNAWalker2_validate -0.214068571846646 4.81258702820553e-07 NA NA NA hsa-miR-186-5p ERLIN2 -0.246324984406451 0.701310703524093 0.0155537175380891 0.977253393227077 mirMAP -0.110944450676559 0.038503403209968 NA NA NA hsa-miR-192-5p ERLIN2 -0.00281508349767456 0.99638352116085 0.0155537175380891 0.977253393227077 miRNAWalker2_validate -0.111853196328241 0.000418541447507275 NA NA NA hsa-miR-23a-3p ERLIN2 0.174045248211037 0.865717934161724 0.0155537175380891 0.977253393227077 MirTarget;mirMAP -0.184033873329043 0.000267545556182982 NA NA NA hsa-miR-148a-3p ERRFI1 -0.324144803192141 0.746264759480212 0.0831450814570553 0.881700431102294 MirTarget -0.154925211206166 0.0070847249749379 NA NA NA hsa-let-7a-5p ESPL1 0.0514604984725615 0.971564723582327 -0.304027211992956 0.538304037766298 MirTarget;TargetScan -0.302458388802735 1.31631205810732e-05 NA NA NA hsa-let-7b-5p ESPL1 0.396604576702067 0.783406687058469 -0.304027211992956 0.538304037766298 MirTarget -0.348723575117656 7.0782205828371e-11 NA NA NA hsa-miR-125a-5p ESPL1 -0.00666761469427968 0.994891296705929 -0.304027211992956 0.538304037766298 miRanda -0.40984964918287 1.16052960763406e-05 NA NA NA hsa-miR-150-5p ESR2 -0.00683324482969283 0.994067057151257 -1.0594327856377 0.000526723931049 mirMAP -0.171381556299187 6.48811594021669e-05 NA NA NA hsa-miR-15b-5p ESRRG 0.251826642099145 0.790709218602499 0.964494392813018 0.0359709288609969 miRNATAP -0.36194000971874 0.00592193523121315 NA NA NA hsa-miR-15b-5p ETNK1 0.251826642099145 0.790709218602499 0.0784197702546221 0.88043073381994 miRNAWalker2_validate;MirTarget -0.150526463923368 0.00272878162117659 NA NA NA hsa-miR-660-5p ETV1 -0.561687438133488 0.138270972367544 0.551934127902999 0.190947287949481 MirTarget -0.150426154340462 0.0135955138986723 NA NA NA hsa-miR-107 ETV5 -0.289737369453023 0.769655185893943 -0.0732138595467884 0.890560429353369 miRanda -0.181536092106077 0.0468712776880185 NA NA NA hsa-miR-148a-3p ETV5 -0.324144803192141 0.746264759480212 -0.0732138595467884 0.890560429353369 MirTarget;miRNATAP -0.167465811318093 0.0207986181598012 NA NA NA hsa-let-7b-3p EXO1 0.314328399485033 0.684245834514538 -0.269425472696666 0.433824238370078 MirTarget -0.232941025623602 5.05515477409923e-05 NA NA NA hsa-miR-320c EXO1 0.092255964601645 0.785539881268253 -0.269425472696666 0.433824238370078 MirTarget;miRNATAP -0.153807350854381 0.0021858256824475 NA NA NA hsa-miR-660-5p EYA4 -0.561687438133488 0.138270972367544 -0.197703752337886 0.781655040611487 MirTarget -0.392772801151992 0.00280960756402085 NA NA NA hsa-miR-15b-5p EZH1 0.251826642099145 0.790709218602499 -0.193724269076709 0.660390293436418 MirTarget;miRNATAP -0.141844707990391 0.000910286231860889 NA NA NA hsa-let-7a-5p EZH2 0.0514604984725615 0.971564723582327 -0.329951155823257 0.461648907265252 miRNAWalker2_validate;miRNATAP -0.129631854004752 0.036834822033781 NA NA NA hsa-let-7b-5p EZH2 0.396604576702067 0.783406687058469 -0.329951155823257 0.461648907265252 miRNATAP -0.190608971590846 8.08309257266676e-05 25611389 Significant inverse correlation between EZH2 and hsa-miR-26a-5p R2=0.56 P=0.0001 and hsa-let-7b-5p R2=0.19 P=0.02 expression was observed in the same samples corroborating the belief of EZH2 being a bona fide target for these two miRNAs in CRC colorectal cancer hsa-miR-101-3p EZH2 -0.0149915187591869 0.981999725022451 -0.329951155823257 0.461648907265252 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.192999456712535 0.0002180735102287 21818714;25260883;24002871;26718325;26251675;22108826;24490857;23962556;25428391;24211739;27620004;22450781;25400732;25190211;22977606;24807198;21321380;22094936;21270667 We explore the role of miR-101 and its interaction with EzH2 in epithelial ovarian carcinoma EOC; CHIP assays revealed that re-expression of miR-101 inhibited the interaction of EzH2 with p21waf1/cip1 promoter;miR 101 regulates expression of EZH2 and contributes to progression of and cisplatin resistance in epithelial ovarian cancer; miR-101 overexpression decreased the expression of EZH2 reduced proliferation and migration of ovarian cancer cells and resensitized drug-resistant cancer cells to cisplatin-induced cytotoxicity suggesting the important role miR-101 plays in ovarian cancer that may be associated with its function as a regulator targeting EZH2;miR-101 in turn inhibits the expression of two subunits of PRC2 EZH2 and EED thus creating a double-negative feedback loop that regulates the process of hepatocarcinogenesis; In addition co-overexpression of c-Myc and EZH2 in HCC samples was closely associated with lower expression of miR-101 P < 0.0001 and poorer prognosis of HCC patients P < 0.01;Reporter gene assays revealed that ectopic expression of EZH2 inhibited the transcriptional activities of miR-101-1 promoter; Moreover our results also demonstrated that similar antitumor effects can be achieved either by ectopic miR-101 or EZH2 silencing in HCC cells; These findings show that elevated EZH2 contributes to miR-101 deregulation in HCC and highlight the coordinated role of miR-101 and EZH2 in hepatocarcinogenesis;MiR-101 is a microRNA involved in a negative feedback circuit with EZH2 in different normal and tumor tissues; To that miR-101 can behave as a tumor suppressor in several cancers by repressing EZH2 expression; We therefore evaluated whether miR-101 is de-regulated in eRMS and investigated its interplaying with EZH2 as well as its role in the in vitro tumorigenic potential of these tumor cells; Herein we report that miR-101 is down-regulated in eRMS patients and in tumor cell lines compared to their controls showing an inverse pattern of expression with EZH2; We also show that miR-101 is up-regulated in eRMS cells following both genetic and pharmacological inhibition of EZH2; In turn miR-101 forced expression reduces EZH2 levels as well as restrains the migratory potential of eRMS cells and impairs their clonogenic and anchorage-independent growth capabilities; This phenomenon is associated to reduced H3K27me3 levels at the same regulatory locus indicating that EZH2 directly targets miR-101 for repression in eRMS cells; Altogether our data show that in human eRMS miR-101 is involved in a negative feedback loop with EZH2 whose targeting has been previously shown to halt eRMS tumorigenicity;Mechanistic investigations revealed that reexpression of miR-101 was sufficient to limit the expression of EZH2 and the proinvasive cell surface adhesion molecule EpCAM;Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid induced apoptosis through down regulation of EZH2 expression by miR 101; Furthermore treatment of bladder cancer cells with a combination of GA and MJ induced synergistic inhibition of the enhancer of zeste homologue 2 EZH2 expression whereas miR-101 expression was up-regulated; Conversely knockdown of miR-101 restored this decreased expression of EZH2 and suppressed the inhibitory effect of GA and MJ on the growth of bladder cancer cells; MJ sensitizes bladder cancer cells to GA-induced apoptosis by down-regulating the expression of EZH2 induced by miR-101;MiR 101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2; Functional assays showed that miR-101 suppressed invasion and proliferation - an outcome that could be phenocopied by siRNA knockdown of MITF and EZH2;The results showed that mir-101 was down-regulated and EZH2 were upregulated; Subsequently the roles of mir-101 and EZH2 in tumor growth and progression in vitro were tested; Overexpression of mir-101 mimics was able to suppress the expression of EZH2 in XWLC-05 cells; Interleukin-1β subsequently induces the downregulation of mir-101 which may result in the upregulated level of EZH2 and occurrence of lung cancer;The aim of our study was to investigate the functional role of both miR-101 and EZH2 in human hepatocellular carcinoma HCC; MiR-101 and EZH2 expressions were evaluated in tumor tissues of 99 HCC patients and 7 liver cancer cell lines by real-time PCR; Luciferase reporter assay was employed to validate whether EZH2 represents a target gene of miR-101; MiR-101 expression was significantly downregulated in most of HCC tissues and all cell lines whereas EZH2 was significantly overexpressed in most of HCC tissues and all cell lines; There was a negative correlation between expression levels of miR-101 and EZH2; Luciferase assay results confirmed EZH2 as a direct target gene of miR-101 which negatively regulates EZH2 expression in HCC; Tumor suppressor miR-101 represses HCC progression through directly targeting EZH2 oncogene and sensitizes liver cancer cells to chemotherapeutic treatment;Long non coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR 101 to modulate EZH2 expression;Moreover around 40% of cases showing miR-101 down-regulation displayed concomitant EZH2 over-expression at the RNA and protein levels which in turn was associated with loss/aberrant expression of E-cadherin; In conclusion we show that deletions and/or microdeletions at both miR-101 genomic loci cause mature miR-101 down-regulation subsequent EZH2 over-expression and E-cadherin dysfunction specifically in intestinal-type GC;miR 101 suppresses tumor proliferation and migration and induces apoptosis by targeting EZH2 in esophageal cancer cells; The expression level of miR-101 was inversely correlated to EZH2 protein expression in ESCC cell; These findings suggest that decreased expression of miR-101 might promote metastasis of human ESCC by inducing accumulation of EZH2 protein;In the present study we reported that ectopic overexpression of miR-101 downregulated the expression level of EZH2 and significantly inhibited migration and invasion of osteosarcoma cells; In addition knockdown of EZH2 by siRNA showed the same effect of miR-101 on migration and invasion; To conclude these results indicate that miR-101 may act as a tumor suppressor in osteosarcoma as it has a suppressive role in cell migration and invasion by targeting EZH2;Therefore we aimed to ascertain whether or not the overexpression of miR-101 inhibits invasion of lung cancer through regulation of EZH2; In this study the expression of miR-101 was down-regulated and the expression of EZH2 was up-regulated in lung cancer; Overexpression of miR-101 induced a marked reduction in EZH2 mRNA levels in several lung cancer cell lines; miR-101 may be a potent tumor suppressor by altering chromatin structure through repression of EZH2 and may be a potential therapeutic tool for patients with lung cancer;MiR 101 downregulated in retinoblastoma functions as a tumor suppressor in human retinoblastoma cells by targeting EZH2; Finally we found that miR-101 directly inhibited EZH2 expression by targeting its 3'-UTR and EZH2 was upregulated and inversely correlated with miR-101 expression in the retinoblastoma tissues; Thus for the first time we provide convincing evidence that downregulation of miR-101 is associated with tumor aggressiveness in retinoblastoma and inhibits cell growth and proliferation of retinoblastoma cells by targeting EZH2;miR 101 is down regulated in glioblastoma resulting in EZH2 induced proliferation migration and angiogenesis; Here we determined that miR-101 is down-regulated in GBM resulting in overexpression of the miR-101 target PcG protein EZH2 a histone methyltransferase affecting gene expression profiles in an epigenetic manner; Our results indicate that EZH2 has a versatile function in GBM progression and that its overexpression is at least partly due to decreased miR-101 expression;Main objective of the present study is to investigate miR-26a and miR-101 levels which both target EZH2 for their association with molecular pathways and with efficacy of tamoxifen as first-line monotherapy for metastatic breast cancer;In this study we investigate whether miRNA miR-101 regulates EZH2 expression in NSCLC; We evaluated the expression of miR-101 and EZH2 in 20 matched NSCLC and adjacent nontumor lung tissues by reverse-transcriptase polymerase chain reaction and immunohistochemistry respectively; Luciferase reporter assay was used to determine whether miR-101 directly targets EZH2; To assess the effect of miR-101 on NSCLC biological behavior cell proliferation invasion and response to chemotherapy were analyzed using NSCLC cells transfected with miR-101 mimics or transfected with specific small interfering RNA to deplete EZH2 small interfering RNA-EZH2; Reduced expression of miR-101 was associated with overexpression of EZH2 in NSCLC tumor tissues; Transfection of miR-101 mimics significantly suppressed the activity of the luciferase reporter containing wild type but not mutant EZH2 3'-UTR and decreased EZH2 expression in NSCLC cell lines; Therapeutic strategies to rescue miR-101 expression or silence EZH2 may be beneficial to patients with NSCLC in the future ;progression;drug resistance;tumorigenesis;worse prognosis;tumorigenesis;;;;;progression;progression;progression;;metastasis;cell migration;;;progression;;drug resistance ovarian cancer;ovarian cancer;liver cancer;liver cancer;sarcoma;pancreatic cancer;bladder cancer;melanoma;lung cancer;liver cancer;gastric cancer;gastric cancer;esophageal cancer;sarcoma;lung cancer;retinoblastoma;glioblastoma;breast cancer;lung squamous cell cancer hsa-miR-199a-5p EZH2 0.248253058498817 0.7461266806999 -0.329951155823257 0.461648907265252 miRNAWalker2_validate -0.128622956989519 0.000300930290014765 NA NA NA hsa-miR-26a-5p EZH2 0.0483232931294246 0.955218190818435 -0.329951155823257 0.461648907265252 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.211003525302126 0.00145766892957499 20952513;23750239;25611389;24452597;26733151;21901171;25494962;27517917;22086681;27562865;22930729;22094936 Pathologically decreased miR 26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer; Subsequently MTDH and EZH2 are identified as two direct targets of miR-26a and they are significantly upregulated in breast cancer; MCF7 xenografts with exogenous miR-26a show that a decrease in expression of both MTDH and EZH2 is accompanied by an increase in apoptosis; Our findings suggest that miR-26a functionally antagonizes human breast carcinogenesis by targeting MTDH and EZH2;MiR-26a has been reported as a tumor suppressor microRNA in breast cancer which is attributed mainly to targeting of MTDH and EZH2 however the expression profile and therapeutic potential of miR-26a is still unclear;Significant inverse correlation between EZH2 and hsa-miR-26a-5p R2=0.56 P=0.0001 and hsa-let-7b-5p R2=0.19 P=0.02 expression was observed in the same samples corroborating the belief of EZH2 being a bona fide target for these two miRNAs in CRC;Moreover EZH2 was upregulated and inversely correlated with miR-26a expression in the osteosarcoma tissues; Thus for the first time we provide convincing evidence that downregulation of miR-26a is associated with tumor aggressiveness and tumor metastasis and miR-26a inhibits cell migration and invasion by targeting the EZH2 gene in osteosarcoma;Through down-regulation of EZH2 expression and up-regulation of E-cadherin expression miR-26a inhibited the EMT process in vitro and in vivo; Luciferase reporter assay showed that miR-26a directly interacted with EZH2 messenger RNA mRNA; Furthermore the expression of miR-26a was positively correlated with E-cadherin expression and inversely correlated with EZH2 expression in human HCC tissue; miR-26a inhibited the EMT process in HCC by down-regulating EZH2 expression;Previously EZH2 was shown to be regulated by miR-26a at the translational levels in lymphomas;miR 26a promoted by interferon alpha inhibits hepatocellular carcinoma proliferation and migration by blocking EZH2; Here we report that the IFN-α-induced microRNA-26a miR-26a can inhibit HCC proliferation and invasion by suppressing enhancer of zeste homologue 2 EZH2 expression in tumor cells; It was shown that there was increased miR-26a accompanied with downregulated EZH2 expression in the HCC specimens and EZH2 mRNA levels were inversely correlated with miR-26a expression; In addition the miR-26a mimic transfection decreased the EZH2 expression level significantly in the transfected HepG2 cells and inhibited HepG2 cell proliferation and invasion effectively; Our results indicate that miR-26a exerts growth inhibition in HCC and that its inhibitory effect is mediated briefly by blocking EZH2 expression;miR-26a inhibition partly prevents the metformin viability effect and the PTEN and EZH2 expression reduction;We also found that reexpression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in pancreatic cancer cells;In the present study the influence of miR-26a and miR-138 on EZH2 and cellular function including the impact on the cell cycle regulating network was evaluated in PCa cells; The present findings suggest an anti-proliferative role for miR-26a and miR-138 in PCa by blocking the G1/S-phase transition independent of EZH2 but via a concerted inhibition of crucial cell cycle regulators;We propose the hypermethylation of miR-26a as an alternative pathway of ERG rearrangement-independent EZH2 activation;High miR 26a and low CDC2 levels associate with decreased EZH2 expression and with favorable outcome on tamoxifen in metastatic breast cancer; Main objective of the present study is to investigate miR-26a and miR-101 levels which both target EZH2 for their association with molecular pathways and with efficacy of tamoxifen as first-line monotherapy for metastatic breast cancer; Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Cell cycle regulation is the only overlapping pathway linked to miR-26a and EZH2 levels; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen tumorigenesis;;;metastasis;cell migration;;;;;;;; breast cancer;breast cancer;colorectal cancer;sarcoma;liver cancer;acute myeloid leukemia;liver cancer;breast cancer;pancreatic cancer;prostate cancer;prostate cancer;breast cancer hsa-miR-429 F2R -0.596617415946644 0.128967410286089 0.0840856082935533 0.862437584782297 miRanda -0.104515956793304 0.0251103629809147 NA NA NA hsa-miR-664a-3p F2R -0.139841943049965 0.800834383581795 0.0840856082935533 0.862437584782297 mirMAP -0.158904503725937 0.0157383415415167 NA NA NA hsa-miR-429 FABP5 -0.596617415946644 0.128967410286089 0.475135197492101 0.222572855686192 miRanda -0.176354738637914 0.0192009787628277 NA NA NA hsa-miR-320c FADS1 0.092255964601645 0.785539881268253 -0.393828340057235 0.439899250793333 mirMAP -0.190325187847309 0.0027710606990273 NA NA NA hsa-miR-429 FADS1 -0.596617415946644 0.128967410286089 -0.393828340057235 0.439899250793333 miRanda -0.141075775187594 0.00937372644277063 NA NA NA hsa-miR-342-3p FAM107A -0.233020179388453 0.739959578456401 0.838663679715603 0.25027465705821 miRanda -0.383720608822892 0.00359276153469013 NA NA NA hsa-miR-432-5p FAM107A 0.0159410675083036 0.977157776645728 0.838663679715603 0.25027465705821 mirMAP -0.151172361528891 0.0254865668564718 NA NA NA hsa-miR-877-3p FAM107A -0.228887480748248 0.565006251347097 0.838663679715603 0.25027465705821 MirTarget -0.31781384009375 0.000105820796935845 NA NA NA hsa-miR-940 FAM107A 0.19340062942074 0.679749292292113 0.838663679715603 0.25027465705821 MirTarget -0.251889747291935 0.00521548386375256 NA NA NA hsa-miR-15b-5p FAM110C 0.251826642099145 0.790709218602499 -0.15347538293444 0.625000918371107 MirTarget -0.292092530509792 0.000537235774301405 NA NA NA hsa-miR-129-5p FAM129A 0.417083435812871 0.454236109516901 -0.290049542332749 0.548707489184679 mirMAP -0.103943847219151 0.0297117142164099 NA NA NA hsa-miR-17-5p FAM129A -0.643066792834501 0.320674049526638 -0.290049542332749 0.548707489184679 TargetScan -0.137670899275209 0.0499557995509759 26317551 The expression of two selected microRNAs miR-17-5p miR-106b and the expression of C1orf24 were tested in 48 benign and malignant thyroid lesions and in five thyroid carcinoma cell lines malignant trasformation thyroid cancer hsa-miR-296-3p FAM129A 0.305371903227786 0.470342914513253 -0.290049542332749 0.548707489184679 miRanda -0.164891443587184 0.00357138813641464 NA NA NA hsa-miR-107 FAM131B -0.289737369453023 0.769655185893943 0.382441463919371 0.19359078713585 MirTarget -0.175347111323393 0.0414063963147316 NA NA NA hsa-miR-26a-5p FAM136A 0.0483232931294246 0.955218190818435 -0.029601631977636 0.958122209920105 MirTarget;miRNATAP -0.112695674150854 0.00355696135101215 NA NA NA hsa-miR-127-3p FAM153B 0.231539840651733 0.822108193638849 -0.414540662020779 0.437528262684937 miRanda -0.200238423753366 0.0293215950424697 NA NA NA hsa-miR-128-3p FAM155A -0.0364518492233463 0.95841670253784 0.209472062959562 0.598805237801683 MirTarget -0.357044956469628 0.003730956388736 NA NA NA hsa-miR-150-5p FAM155B -0.00683324482969283 0.994067057151257 0.989778664228366 0.0354877920530956 mirMAP -0.167679416046599 0.00756872249738691 NA NA NA hsa-miR-15b-5p FAM189A1 0.251826642099145 0.790709218602499 0.483057875159079 0.322200061338986 MirTarget;miRNATAP -0.374562210890245 0.0109521002783872 NA NA NA hsa-miR-17-5p FAM3C -0.643066792834501 0.320674049526638 0.29027509912782 0.612462934980272 TargetScan -0.171919959402244 1.21706626902697e-06 NA NA NA hsa-miR-181b-5p FAM3C -0.0483087651223055 0.952929800264921 0.29027509912782 0.612462934980272 MirTarget -0.11382014285866 0.00590087704853271 NA NA NA hsa-miR-26a-5p FAM49B 0.0483232931294246 0.955218190818435 0.0628214712897028 0.913931053941339 miRNATAP -0.211478698042667 6.26503549661317e-05 NA NA NA hsa-miR-320c FAM49B 0.092255964601645 0.785539881268253 0.0628214712897028 0.913931053941339 MirTarget;PITA;miRanda;miRNATAP -0.156051328416842 1.89694601974109e-05 NA NA NA hsa-miR-139-5p FAM84B -0.0625698939687087 0.914810329989088 0.124436502360998 0.841994771676338 PITA;miRanda -0.101785003781032 0.0457002145944639 NA NA NA hsa-miR-107 FAM85A -0.289737369453023 0.769655185893943 -0.120566461469749 0.690106811236555 miRanda -0.202080088870525 0.0110296925350799 NA NA NA hsa-miR-128-3p FAM89A -0.0364518492233463 0.95841670253784 0.32304071425821 0.315343848692809 miRNAWalker2_validate -0.220300327112512 0.00175051386401559 NA NA NA hsa-miR-15b-5p FAM89A 0.251826642099145 0.790709218602499 0.32304071425821 0.315343848692809 MirTarget -0.16912076796158 0.0158723221609869 NA NA NA hsa-miR-140-3p FAM91A1 -0.105651799466207 0.9077781740714 0.105223121156462 0.853062419700926 MirTarget;PITA -0.135140340792551 0.000896086776086797 NA NA NA hsa-miR-125a-5p FANCI -0.00666761469427968 0.994891296705929 -0.357401998588816 0.441490999489404 miRanda -0.367018944711852 9.14306598334408e-07 NA NA NA hsa-miR-320c FANCI 0.092255964601645 0.785539881268253 -0.357401998588816 0.441490999489404 miRanda -0.104774559400069 0.0122847267634781 NA NA NA hsa-miR-129-5p FAS 0.417083435812871 0.454236109516901 0.187742411089103 0.667843064117542 miRanda -0.118691866669425 0.000367295331099519 NA NA NA hsa-miR-23a-3p FASTKD3 0.174045248211037 0.865717934161724 -0.100608725441586 0.757769760090956 MirTarget -0.135627579262392 0.000678739496453878 NA NA NA hsa-miR-107 FAT3 -0.289737369453023 0.769655185893943 0.762334009243 0.17189321629208 MirTarget;PITA;miRanda;miRNATAP -0.37014651922116 0.0249803017657094 NA NA NA hsa-miR-15b-5p FAT3 0.251826642099145 0.790709218602499 0.762334009243 0.17189321629208 MirTarget;miRNATAP -0.36459251374834 0.0329334663096922 NA NA NA hsa-miR-107 FAT4 -0.289737369453023 0.769655185893943 0.148255889034354 0.654798419913443 MirTarget;miRanda;miRNATAP -0.206262479191701 0.0075319136623649 NA NA NA hsa-miR-15b-5p FAT4 0.251826642099145 0.790709218602499 0.148255889034354 0.654798419913443 MirTarget -0.176231991744147 0.0276590078018348 NA NA NA hsa-miR-140-3p FAU -0.105651799466207 0.9077781740714 0.244539229177908 0.744293913708948 miRNAWalker2_validate -0.127848333494784 0.00414479584057294 NA NA NA hsa-miR-107 FBLN1 -0.289737369453023 0.769655185893943 0.576180028523965 0.39905139487406 miRanda -0.270414021956049 0.00345873941896126 NA NA NA hsa-miR-200c-3p FBLN5 -0.333638625701646 0.813830738880144 0.2068878882038 0.707084326116773 miRNAWalker2_validate;miRTarBase -0.124190088147568 0.0173826156593057 NA NA NA hsa-miR-616-5p FBLN5 -0.321509218120179 0.271446046739636 0.2068878882038 0.707084326116773 miRNATAP -0.16675474002148 0.00127787308116203 NA NA NA hsa-miR-221-3p FBN3 -0.261179092929062 0.744019631321393 -1.10334327423364 0.148225352306687 miRNAWalker2_validate -0.415986837431374 0.0151766294687209 NA NA NA hsa-miR-132-3p FBXO21 -0.274411442405805 0.710467071857645 -0.0755868280768297 0.908798142118369 MirTarget -0.139520203764287 0.0133296377992338 NA NA NA hsa-miR-15a-5p FBXO21 -0.288312177100971 0.506274963146038 -0.0755868280768297 0.908798142118369 MirTarget;miRNATAP -0.125821866818144 0.00746765635499295 NA NA NA hsa-miR-212-3p FBXO21 -0.118513342558296 0.740632149411935 -0.0755868280768297 0.908798142118369 MirTarget -0.187775780841966 9.67116071708663e-05 NA NA NA hsa-miR-342-3p FBXO21 -0.233020179388453 0.739959578456401 -0.0755868280768297 0.908798142118369 miRanda -0.137926948646854 0.0320373353731767 NA NA NA hsa-miR-493-5p FBXO21 0.446650879308971 0.32421223482789 -0.0755868280768297 0.908798142118369 miRNATAP -0.114492744049476 0.00312627858884347 NA NA NA hsa-miR-140-3p FBXO33 -0.105651799466207 0.9077781740714 -0.0164096888222893 0.969517760593863 PITA -0.111953080687489 0.00123849501657192 NA NA NA hsa-miR-127-3p FBXO43 0.231539840651733 0.822108193638849 -0.364241892791967 0.195385510621802 miRanda -0.156382388009273 0.00168652298113014 NA NA NA hsa-miR-1301-3p FCGBP -0.108695123599309 0.851745507068853 0.230772521031212 0.722473487735067 MirTarget -0.348757857420512 0.00239335218277814 NA NA NA hsa-miR-107 FCGRT -0.289737369453023 0.769655185893943 -0.106814328214593 0.865431098789263 miRNATAP -0.189108897748901 0.000117101341658099 NA NA NA hsa-miR-140-3p FDXACB1 -0.105651799466207 0.9077781740714 0.180590229567563 0.520616460030375 MirTarget -0.17218709669101 7.27831492288687e-05 NA NA NA hsa-miR-125a-5p FEN1 -0.00666761469427968 0.994891296705929 -0.0619875251126896 0.89382576173103 miRanda -0.300874954571174 7.05881984643318e-07 NA NA NA hsa-miR-26a-5p FEN1 0.0483232931294246 0.955218190818435 -0.0619875251126896 0.89382576173103 MirTarget -0.206293315326274 2.18622237011543e-05 NA NA NA hsa-miR-26b-5p FEN1 0.16143906971203 0.790777916193478 -0.0619875251126896 0.89382576173103 MirTarget -0.117044000704882 0.0165283333203275 NA NA NA hsa-miR-107 FGF2 -0.289737369453023 0.769655185893943 0.058626971450581 0.850374937272804 MirTarget;PITA;miRanda;miRNATAP -0.266744326725375 0.00270703228435517 NA NA NA hsa-miR-15b-5p FGF2 0.251826642099145 0.790709218602499 0.058626971450581 0.850374937272804 MirTarget;miRNATAP -0.248923354978811 0.00692005796687104 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-107 FGF7 -0.289737369453023 0.769655185893943 1.32403482825159 0.0046921040226143 PITA;miRanda;miRNATAP -0.388150038975223 0.0044775884821159 NA NA NA hsa-miR-140-3p FGF9 -0.105651799466207 0.9077781740714 -0.0592815773047637 0.910686490901115 miRNATAP -0.28942620671316 0.0433164836687963 NA NA NA hsa-miR-15b-5p FGF9 0.251826642099145 0.790709218602499 -0.0592815773047637 0.910686490901115 miRNATAP -0.383290064327185 0.0173303753407319 NA NA NA hsa-miR-15b-5p FGFR1 0.251826642099145 0.790709218602499 0.29655955190332 0.660646107767996 miRNATAP -0.19780067325161 0.0176217969881733 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-218-5p FGL2 -0.142331684313268 0.733683746687823 -0.144762806941402 0.777632531917322 MirTarget -0.154503985279506 0.00456883860679365 NA NA NA hsa-miR-335-3p FGL2 0.0738544228922926 0.89349398283313 -0.144762806941402 0.777632531917322 MirTarget;mirMAP -0.184876106799734 0.00282870985358549 NA NA NA hsa-miR-200b-3p FHL1 -0.532909690027328 0.555970111970307 0.297481546496991 0.595328780386114 MirTarget -0.209181645434149 0.000845132689401108 NA NA NA hsa-miR-200c-3p FHL1 -0.333638625701646 0.813830738880144 0.297481546496991 0.595328780386114 MirTarget -0.168435148508079 0.011550180271776 NA NA NA hsa-miR-106b-5p FHL2 -0.3941595235172 0.389635342155994 0.0900964232343275 0.877541662406507 mirMAP -0.147474445340615 0.0334830331155568 NA NA NA hsa-miR-93-5p FHL2 -0.375078982324499 0.732311284477601 0.0900964232343275 0.877541662406507 mirMAP -0.155576879747861 0.0184151537918648 NA NA NA hsa-miR-146b-5p FHOD3 0.0340352805627226 0.964565988329585 0.143541771328516 0.677791326517634 miRanda -0.196315746690828 0.000592112603440161 NA NA NA hsa-miR-15b-5p FIBCD1 0.251826642099145 0.790709218602499 0.0725801111921721 0.867473408618604 mirMAP -0.28203316202169 0.0350699323876731 NA NA NA hsa-miR-98-5p FIGN -0.0484028619275874 0.910781316485549 0.0485545645631689 0.910186476245363 MirTarget -0.156397279114503 0.0297077368561123 NA NA NA hsa-miR-197-3p FKBP4 0.0240027695773914 0.981971058073739 -0.00827057781428042 0.99052612769577 miRNAWalker2_validate -0.115746906283958 0.022703683614869 NA NA NA hsa-miR-107 FKBP7 -0.289737369453023 0.769655185893943 0.205347533147915 0.579482063270765 miRanda -0.277632312702028 1.19857259333635e-06 NA NA NA hsa-let-7b-5p FLAD1 0.396604576702067 0.783406687058469 -0.00189215773506568 0.997238144006837 miRNAWalker2_validate -0.12345676719149 7.43350216576439e-06 NA NA NA hsa-miR-27a-3p FLRT3 0.309634509674364 0.703724209648479 -0.107534240817507 0.81385125873655 MirTarget;miRNATAP -0.456590451228253 1.28686507719965e-05 NA NA NA hsa-miR-15b-5p FLYWCH1 0.251826642099145 0.790709218602499 -0.133671617869516 0.754955610933496 mirMAP -0.100835199459012 0.013515175783894 NA NA NA hsa-miR-197-3p FMNL2 0.0240027695773914 0.981971058073739 -0.311512370285661 0.562956049165804 miRNATAP -0.102745171199832 0.0258893985127313 NA NA NA hsa-miR-129-5p FMO2 0.417083435812871 0.454236109516901 0.119952993569678 0.855379684246156 miRanda;mirMAP -0.257166827748382 0.0100470075794166 NA NA NA hsa-miR-182-5p FMO2 -0.262297863136789 0.8110070165759 0.119952993569678 0.855379684246156 MirTarget -0.312689250794673 0.00332320554306064 NA NA NA hsa-miR-335-3p FMO2 0.0738544228922926 0.89349398283313 0.119952993569678 0.855379684246156 mirMAP -0.400154730045359 0.00103140528567404 NA NA NA hsa-miR-221-3p FNBP1L -0.261179092929062 0.744019631321393 -0.132175775261637 0.819293769680038 mirMAP -0.118058641332911 0.000241677409971907 NA NA NA hsa-miR-222-3p FNBP1L -0.233673471709747 0.726651775432807 -0.132175775261637 0.819293769680038 mirMAP -0.139105124451183 1.18132254980838e-05 NA NA NA hsa-miR-221-3p FNDC3A -0.261179092929062 0.744019631321393 0.0881446526618488 0.867823381527224 MirTarget;miRNATAP -0.115637845718578 0.000296353825132234 NA NA NA hsa-miR-222-3p FNDC3A -0.233673471709747 0.726651775432807 0.0881446526618488 0.867823381527224 MirTarget;miRNATAP -0.135759356747828 1.69538804666545e-05 NA NA NA hsa-miR-107 FNDC4 -0.289737369453023 0.769655185893943 0.486829938341624 0.157978593139745 miRanda -0.344196112048426 7.8034675304698e-06 NA NA NA hsa-miR-199a-5p FOXJ1 0.248253058498817 0.7461266806999 -0.196933925780481 0.766892336665625 miRanda -0.264268360892723 0.000697058267523576 NA NA NA hsa-miR-15b-5p FOXK1 0.251826642099145 0.790709218602499 -0.33594195315421 0.534710925936459 miRNAWalker2_validate -0.141499735215294 0.0156696450417539 NA NA NA hsa-miR-23b-3p FOXL2 0.188949711826471 0.848360545615343 -0.796003262575461 0.245757926300613 miRNATAP -0.832240029858593 7.52068537680117e-06 NA NA NA hsa-miR-320a FOXL2 0.142884703798297 0.888511174254355 -0.796003262575461 0.245757926300613 miRanda -0.453807993249076 0.0168574533283537 NA NA NA hsa-miR-320b FOXL2 0.298760649675195 0.700446828731538 -0.796003262575461 0.245757926300613 miRanda -0.324483919933806 0.0339388130814113 NA NA NA hsa-miR-320d FOXL2 0.353471568894745 0.357430999251147 -0.796003262575461 0.245757926300613 miRanda -0.270752230570022 0.0270254846183526 NA NA NA hsa-miR-320c FOXM1 0.092255964601645 0.785539881268253 -0.302373176168827 0.617074680756509 MirTarget;miRanda -0.148026109195023 0.00322892452859573 NA NA NA hsa-miR-182-5p FOXO1 -0.262297863136789 0.8110070165759 0.0524076203087223 0.921148727781111 miRNAWalker2_validate;miRTarBase;miRNATAP -0.144918199977638 7.00118307848296e-06 24865442;26640590;23313739 Immunohistochemical analysis revealed that the levels of FOXO1 and FOXO3A two potential miR-182 targets are reduced in AA tumors;MiR 182 Is Associated with Growth Migration and Invasion in Prostate Cancer via Suppression of FOXO1; Our findings suggest that miR-182 may act to increase prostate cancer proliferation migration and invasion through suppression of FOXO1;Western blot flow cytometry and pathway analysis for the HeLa cells with miR-182 over/down-expression in vitro showed that miR-182 was involved in apoptosis and cell cycle pathways it also associated with the regulation of FOXO1 ;; colon cancer;prostate cancer;cervical and endocervical cancer hsa-miR-183-5p FOXO1 -0.0462269171194745 0.969489414828393 0.0524076203087223 0.921148727781111 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.141073337708262 2.18530708005306e-05 25813403;25983004 Knockdown of CTNNB1 also showed concordant down-regulations of miR-183 -96 and -182 and the re-expression of FOXO1;MiR 183 promotes growth of non small cell lung cancer cells through FoxO1 inhibition; Here we analyzed the regulation of FoxO1 by miR-183 in vitro using luciferase-reporter assay; Moreover miR-183 bound to FoxO1 mRNA to prevent its translation through its 3'untranslated region UTR; Furthermore administration of miR-183 suppressed FoxO1 levels in NSCLC resulting in a significant increase in NSCLC growth in vitro and in vivo while administration of antisense of miR-183 significantly increased FoxO1 levels in NSCLC resulting in a significant decrease in NSCLC growth ; liver cancer;lung squamous cell cancer hsa-miR-194-5p FOXO1 -0.141051051043955 0.809072276924359 0.0524076203087223 0.921148727781111 miRNATAP -0.165381242503418 1.46715971099572e-05 24631529 Gα12gep oncogene inhibits FOXO1 in hepatocellular carcinoma as a consequence of miR 135b and miR 194 dysregulation; In addition Gα12QL repressed miR-194 cluster gene products 194/192/215 which contributed to MDM2-mediated FOXO1 repression; Moreover decrease of FOXO1 or miR-194 was statistically significant between stages T1 and T2 whereas increase of miR-135b discriminated tumor stage T3a versus T1/T2 staging liver cancer hsa-miR-324-3p FOXO1 -0.244363119878663 0.713004048957448 0.0524076203087223 0.921148727781111 MirTarget -0.160840868172079 0.00958006218560029 NA NA NA hsa-miR-324-5p FOXO1 -0.358991607952497 0.499732551112182 0.0524076203087223 0.921148727781111 MirTarget;miRanda;miRNATAP -0.175335699692803 0.000758880758788194 NA NA NA hsa-miR-98-5p FOXO1 -0.0484028619275874 0.910781316485549 0.0524076203087223 0.921148727781111 miRNAWalker2_validate -0.117128048202187 0.00274919240886909 NA NA NA hsa-miR-363-3p FOXP2 -0.186046567396088 0.728622856049059 0.681748078951173 0.255638486836718 miRNATAP -0.200720249840718 0.00943095534509937 NA NA NA hsa-miR-98-5p FOXP2 -0.0484028619275874 0.910781316485549 0.681748078951173 0.255638486836718 MirTarget -0.22225541388062 0.0372905260113753 NA NA NA hsa-miR-128-3p FOXQ1 -0.0364518492233463 0.95841670253784 -0.558622922085247 0.378224255950241 MirTarget -0.292464119583977 0.0341442923286193 NA NA NA hsa-miR-107 FREM2 -0.289737369453023 0.769655185893943 0.511266958584365 0.442454605236576 miRanda -0.604926256562268 0.00214530298579255 NA NA NA hsa-miR-15b-5p FRY 0.251826642099145 0.790709218602499 0.114529189689952 0.774844503144856 miRNATAP -0.177587383785851 0.0144752666902669 NA NA NA hsa-miR-25-3p FRY 0.0681841609869576 0.955267320175687 0.114529189689952 0.774844503144856 MirTarget;miRNATAP -0.228418577792075 0.00355357057231979 NA NA NA hsa-miR-324-3p FRY -0.244363119878663 0.713004048957448 0.114529189689952 0.774844503144856 MirTarget -0.217390709294428 0.00305408475863457 NA NA NA hsa-miR-363-3p FRY -0.186046567396088 0.728622856049059 0.114529189689952 0.774844503144856 MirTarget -0.116561423673339 0.000509470800819444 NA NA NA hsa-miR-221-3p FSCN1 -0.261179092929062 0.744019631321393 -0.166097381777673 0.802191165834126 miRNAWalker2_validate -0.218710293595817 0.000186523986063969 NA NA NA hsa-let-7a-3p FYN 0.0395190175369595 0.888702137550015 -0.0572988048973428 0.908461168426155 miRNATAP -0.154895758504529 0.00923863156896139 NA NA NA hsa-let-7b-3p FYN 0.314328399485033 0.684245834514538 -0.0572988048973428 0.908461168426155 miRNATAP -0.176654659061704 0.00672188661248878 NA NA NA hsa-miR-200b-3p FYN -0.532909690027328 0.555970111970307 -0.0572988048973428 0.908461168426155 TargetScan -0.146276804696616 0.00262453608381479 NA NA NA hsa-miR-200c-3p FYN -0.333638625701646 0.813830738880144 -0.0572988048973428 0.908461168426155 miRNATAP -0.158600582018602 0.00207436364914187 NA NA NA hsa-miR-27a-3p FYN 0.309634509674364 0.703724209648479 -0.0572988048973428 0.908461168426155 miRNATAP -0.270104810126542 2.70101207081925e-05 NA NA NA hsa-miR-29a-3p FYN 0.203872357562561 0.859946061784007 -0.0572988048973428 0.908461168426155 miRNATAP -0.259723840866517 1.28968999527052e-05 NA NA NA hsa-miR-29b-3p FYN -0.249746665931503 0.558208927436524 -0.0572988048973428 0.908461168426155 miRNATAP -0.158365551080839 0.000181712237604759 NA NA NA hsa-miR-29c-3p FYN 0.042533372292219 0.941334605544826 -0.0572988048973428 0.908461168426155 miRNATAP -0.184853739183787 0.000146599448700209 NA NA NA hsa-miR-30d-5p FYN -0.127037899273548 0.917197761243139 -0.0572988048973428 0.908461168426155 miRNATAP -0.22341648991239 0.00174778770447193 NA NA NA hsa-miR-330-5p FYN -0.152605584680815 0.787259112745893 -0.0572988048973428 0.908461168426155 miRNATAP -0.211599331803924 0.00113432399233346 NA NA NA hsa-miR-128-3p G0S2 -0.0364518492233463 0.95841670253784 -0.0824901298409455 0.818781899853032 MirTarget -0.246347232864067 0.00532198790036494 NA NA NA hsa-miR-130a-3p G0S2 -0.0153771286384572 0.977389403395331 -0.0824901298409455 0.818781899853032 MirTarget -0.218970749388778 0.00329604688472104 NA NA NA hsa-miR-128-3p G6PC3 -0.0364518492233463 0.95841670253784 0.118005028517512 0.84076483423883 miRNAWalker2_validate -0.127846763788332 0.00222210641485169 NA NA NA hsa-miR-222-3p GAB1 -0.233673471709747 0.726651775432807 0.131313474185227 0.736898982797813 MirTarget;miRNATAP -0.117781298813923 0.00125275843768857 NA NA NA hsa-miR-107 GABBR2 -0.289737369453023 0.769655185893943 0.987433661368056 0.121911531856517 miRanda -0.457530586218331 0.0171473409699305 NA NA NA hsa-miR-221-3p GABRG1 -0.261179092929062 0.744019631321393 0.384291383272049 0.562487846560542 MirTarget -0.580572846540624 1.28635268129421e-05 NA NA NA hsa-miR-222-3p GABRG1 -0.233673471709747 0.726651775432807 0.384291383272049 0.562487846560542 MirTarget -0.600009300902346 5.34792018517211e-06 NA NA NA hsa-miR-148a-3p GADD45A -0.324144803192141 0.746264759480212 0.0120580708134579 0.980879202757005 MirTarget;miRNATAP -0.10683970314889 0.0278518969898176 NA NA NA hsa-miR-148a-3p GAS1 -0.324144803192141 0.746264759480212 0.620352112283554 0.329262575295139 miRNAWalker2_validate -0.156972690369108 0.0430310916983582 NA NA NA hsa-miR-128-3p GAS7 -0.0364518492233463 0.95841670253784 0.415522653953422 0.40610863926007 miRNAWalker2_validate -0.149725529853598 0.0465616951129647 NA NA NA hsa-miR-10a-5p GATA6 1.19119642172218 0.344847521234295 -0.521829108607867 0.375362609146716 miRNATAP -0.19842472143767 9.95782612287756e-05 NA NA NA hsa-miR-183-5p GATA6 -0.0462269171194745 0.969489414828393 -0.521829108607867 0.375362609146716 miRNAWalker2_validate -0.270290568165625 2.8097265036792e-05 NA NA NA hsa-miR-27a-3p GATC 0.309634509674364 0.703724209648479 -0.146757567893831 0.521310669102217 MirTarget;miRNATAP -0.1676968869639 4.36332555843268e-05 NA NA NA hsa-miR-22-3p GATM 0.0468440219945929 0.967778504781139 0.0952376258924255 0.820377695068492 MirTarget -0.174815664841574 0.00425658701604071 NA NA NA hsa-miR-98-5p GDF6 -0.0484028619275874 0.910781316485549 0.853461935928502 0.0855452478097496 MirTarget -0.218804069562373 0.0240565029197208 NA NA NA hsa-miR-129-5p GEM 0.417083435812871 0.454236109516901 0.315574872942366 0.385177803823037 miRanda -0.106370045962634 0.0288670619291513 NA NA NA hsa-miR-141-3p GEM -0.36932301319088 0.428364456128406 0.315574872942366 0.385177803823037 MirTarget -0.322451680201334 1.68384925738833e-05 NA NA NA hsa-miR-200a-3p GEM -0.801422367541981 0.147987649395985 0.315574872942366 0.385177803823037 MirTarget -0.292510178483837 6.51173802526588e-07 NA NA NA hsa-miR-200b-3p GEM -0.532909690027328 0.555970111970307 0.315574872942366 0.385177803823037 MirTarget -0.262909555651012 1.63861346163525e-05 NA NA NA hsa-miR-200c-3p GEM -0.333638625701646 0.813830738880144 0.315574872942366 0.385177803823037 MirTarget;miRNATAP -0.308353186983618 1.69322640944661e-06 NA NA NA hsa-miR-429 GEM -0.596617415946644 0.128967410286089 0.315574872942366 0.385177803823037 MirTarget;PITA;miRanda;miRNATAP -0.130335530408348 0.0330507287511884 NA NA NA hsa-miR-363-3p GFOD1 -0.186046567396088 0.728622856049059 -0.171160331773094 0.664414182012271 mirMAP -0.106815130186124 0.0100395895834844 NA NA NA hsa-miR-363-3p GFPT2 -0.186046567396088 0.728622856049059 0.558234934992865 0.230867215569602 MirTarget;miRNATAP -0.120753030628479 0.0297234981743336 NA NA NA hsa-miR-26b-5p GGH 0.16143906971203 0.790777916193478 0.145476692091522 0.770692137217977 miRNAWalker2_validate -0.311828655759847 0.000204614239633577 NA NA NA hsa-miR-197-3p GGT7 0.0240027695773914 0.981971058073739 0.142278025918599 0.767680925616585 MirTarget -0.136174785466488 0.0162822122106235 NA NA NA hsa-miR-15b-5p GHR 0.251826642099145 0.790709218602499 0.586796983544641 0.127805103754163 MirTarget;miRNATAP -0.262150204069418 0.0188125091445233 NA NA NA hsa-miR-16-5p GHR -0.199225750365017 0.742834324195084 0.586796983544641 0.127805103754163 MirTarget;miRNATAP -0.242677498363239 0.00832568424622213 NA NA NA hsa-miR-361-5p GHR -0.278147578656315 0.728553069590798 0.586796983544641 0.127805103754163 miRanda -0.436896966506125 0.00176137089477481 NA NA NA hsa-miR-429 GHR -0.596617415946644 0.128967410286089 0.586796983544641 0.127805103754163 miRanda;miRNATAP -0.248551680434335 0.000343404961551242 NA NA NA hsa-miR-324-5p GIMAP6 -0.358991607952497 0.499732551112182 -0.219284083621667 0.579188104009823 miRanda -0.12730074907262 0.0314680342952483 NA NA NA hsa-miR-26b-5p GINS1 0.16143906971203 0.790777916193478 -0.0324288139026141 0.936489439248265 miRNAWalker2_validate -0.245442822853458 2.57478544941525e-05 NA NA NA hsa-miR-30b-3p GINS1 -0.231361964211179 0.496038769366155 -0.0324288139026141 0.936489439248265 MirTarget -0.164706047036194 0.000174691745418605 NA NA NA hsa-miR-664a-3p GINS1 -0.139841943049965 0.800834383581795 -0.0324288139026141 0.936489439248265 mirMAP -0.252380092314774 1.85414460890123e-07 NA NA NA hsa-miR-320c GINS2 0.092255964601645 0.785539881268253 0.164270337552074 0.65105275768373 miRanda -0.204765926451085 4.10477162246073e-05 NA NA NA hsa-miR-320d GINS2 0.353471568894745 0.357430999251147 0.164270337552074 0.65105275768373 miRanda -0.114665092747502 0.00355022156024825 NA NA NA hsa-miR-26b-5p GINS4 0.16143906971203 0.790777916193478 -0.226511074133641 0.542356049863752 miRNAWalker2_validate -0.185870446528898 0.0076783507637892 NA NA NA hsa-miR-664a-3p GINS4 -0.139841943049965 0.800834383581795 -0.226511074133641 0.542356049863752 mirMAP -0.273998146771401 1.93773112280259e-06 NA NA NA hsa-miR-877-5p GLDC -0.734829979266612 0.187061190699743 0.785252087087829 0.225454034298367 MirTarget -0.278390171561733 0.0122983785305358 NA NA NA hsa-miR-222-3p GLO1 -0.233673471709747 0.726651775432807 -0.0187868194733642 0.97794028095606 miRNAWalker2_validate -0.136689965401255 7.23163898740591e-05 NA NA NA hsa-miR-150-5p GLP1R -0.00683324482969283 0.994067057151257 0.383368137950096 0.560124884267774 miRNATAP -0.366243521323068 4.38064837779383e-06 NA NA NA hsa-miR-27a-3p GLRA2 0.309634509674364 0.703724209648479 -0.39423020847913 0.575510483632977 miRNATAP -0.476189856775071 0.00174875992217197 NA NA NA hsa-miR-128-3p GLTSCR2 -0.0364518492233463 0.95841670253784 0.115901340635376 0.867588028528667 miRNAWalker2_validate -0.237130885515557 3.69217852552024e-05 NA NA NA hsa-miR-16-5p GLTSCR2 -0.199225750365017 0.742834324195084 0.115901340635376 0.867588028528667 miRNAWalker2_validate -0.158754250950994 0.000793483618728367 NA NA NA hsa-miR-107 GLUD2 -0.289737369453023 0.769655185893943 0.17188444227723 0.671705795296471 PITA;miRanda -0.116809045411901 0.0108365389835986 NA NA NA hsa-let-7b-3p GMFB 0.314328399485033 0.684245834514538 -0.0272941765737391 0.960244169964064 mirMAP -0.109157424224521 0.000240676245883973 NA NA NA hsa-let-7e-5p GMPS -0.421901553764044 0.703151344854989 0.123763998747572 0.827873760223752 miRNAWalker2_validate -0.127653336107534 0.00143565122530168 NA NA NA hsa-miR-26a-5p GMPS 0.0483232931294246 0.955218190818435 0.123763998747572 0.827873760223752 mirMAP -0.165496602859991 0.000221311877830479 NA NA NA hsa-miR-15b-5p GNA12 0.251826642099145 0.790709218602499 -0.221602647173709 0.682793287699566 MirTarget -0.101524127512423 0.010364599672756 NA NA NA hsa-miR-107 GNAO1 -0.289737369453023 0.769655185893943 0.744609715084226 0.145113879831662 miRNATAP -0.4315428399075 0.00176040099562656 NA NA NA hsa-miR-27a-3p GNAZ 0.309634509674364 0.703724209648479 0.0593504123341142 0.867226522857799 miRNATAP -0.149788319481537 0.0168214862510012 NA NA NA hsa-miR-27a-3p GNB5 0.309634509674364 0.703724209648479 0.0416571113163142 0.912559266150247 miRNAWalker2_validate -0.109944996705948 0.0091386300113792 NA NA NA hsa-miR-107 GNG10 -0.289737369453023 0.769655185893943 0.375392517682993 0.409458768698038 miRanda -0.149746359232102 0.000228531001831307 NA NA NA hsa-miR-320b GNG11 0.298760649675195 0.700446828731538 0.509152876859038 0.196560673171664 miRanda -0.125001180921379 0.0103819493011513 NA NA NA hsa-miR-330-5p GNG11 -0.152605584680815 0.787259112745893 0.509152876859038 0.196560673171664 miRanda -0.139137378810031 0.0156203534298932 NA NA NA hsa-miR-107 GNG12 -0.289737369453023 0.769655185893943 0.235141141957482 0.708841299391704 miRanda -0.164469328667423 0.000680546435738928 NA NA NA hsa-miR-107 GNG4 -0.289737369453023 0.769655185893943 -0.363600123772214 0.41260822441083 miRanda -0.356092592679387 0.00493114490027556 NA NA NA hsa-let-7a-5p GOLT1B 0.0514604984725615 0.971564723582327 0.0826155249397393 0.875414743278503 TargetScan -0.133986097810079 0.00917724279800749 NA NA NA hsa-let-7d-5p GOLT1B 0.0119393569456978 0.988390093874148 0.0826155249397393 0.875414743278503 miRNAWalker2_validate -0.198837466912305 1.78357208084725e-05 NA NA NA hsa-miR-16-5p GOLT1B -0.199225750365017 0.742834324195084 0.0826155249397393 0.875414743278503 miRNAWalker2_validate;MirTarget -0.144659150773807 0.000705265973950005 NA NA NA hsa-miR-320a GOLT1B 0.142884703798297 0.888511174254355 0.0826155249397393 0.875414743278503 MirTarget;PITA;miRanda -0.134759611195689 0.00358860867000808 NA NA NA hsa-miR-320b GOLT1B 0.298760649675195 0.700446828731538 0.0826155249397393 0.875414743278503 MirTarget;PITA;miRanda -0.13386079992868 0.000308350649965852 NA NA NA hsa-miR-497-5p GOLT1B -0.345178187351251 0.463288640782623 0.0826155249397393 0.875414743278503 MirTarget -0.176610495282101 1.67868765502565e-07 NA NA NA hsa-miR-664a-3p GOLT1B -0.139841943049965 0.800834383581795 0.0826155249397393 0.875414743278503 MirTarget -0.111904019046749 0.0148420567321667 NA NA NA hsa-miR-27a-3p GPAM 0.309634509674364 0.703724209648479 0.265864360002861 0.485918851699878 miRNAWalker2_validate;MirTarget;miRNATAP -0.127147011922395 0.00396053768129452 NA NA NA hsa-miR-22-3p GPBP1 0.0468440219945929 0.967778504781139 -0.0295484367138661 0.957497175654481 MirTarget;miRNATAP -0.107909576703091 9.54312937441129e-05 NA NA NA hsa-miR-107 GPC6 -0.289737369453023 0.769655185893943 0.698986982223014 0.147090989195263 MirTarget;PITA;miRanda;miRNATAP -0.440795591534833 6.53077786788182e-05 NA NA NA hsa-miR-214-3p GPD1L 0.0312810611346688 0.952640488671912 0.219982362832661 0.658605955673438 MirTarget -0.105338483551295 7.86431388313804e-05 NA NA NA hsa-miR-107 GPR12 -0.289737369453023 0.769655185893943 0.558702940522461 0.522237505895456 miRanda -0.59523126178609 0.0241489459600571 NA NA NA hsa-miR-127-3p GPR82 0.231539840651733 0.822108193638849 0.0251765521044952 0.951089705510675 miRanda -0.174313881113702 0.0184121631025044 NA NA NA hsa-miR-107 GPRASP2 -0.289737369453023 0.769655185893943 -0.310886487837366 0.31158390708351 miRanda -0.133622392957859 0.0226297200837348 NA NA NA hsa-miR-214-3p GPT2 0.0312810611346688 0.952640488671912 -0.21054653782482 0.691123984160395 mirMAP -0.161288926354262 3.50792688645314e-07 NA NA NA hsa-miR-107 GPX8 -0.289737369453023 0.769655185893943 0.25848032086646 0.626347410967487 miRanda -0.154174349960053 0.00428327144511538 NA NA NA hsa-miR-214-3p GRAMD2 0.0312810611346688 0.952640488671912 0.0247731084081293 0.960752351834024 mirMAP -0.168774585743075 0.00427573407239812 NA NA NA hsa-miR-25-3p GRAMD3 0.0681841609869576 0.955267320175687 0.195919798627303 0.713310065295071 MirTarget;miRNATAP -0.15260901535118 0.049383763028446 NA NA NA hsa-miR-92a-3p GRAMD3 0.0155161307487504 0.991444817308063 0.195919798627303 0.713310065295071 MirTarget;miRNATAP -0.219485440717799 0.00297337714855775 NA NA NA hsa-miR-92b-3p GRAMD3 0.454620627632174 0.646193882241421 0.195919798627303 0.713310065295071 MirTarget;miRNATAP -0.137406933698299 0.004332829965309 NA NA NA hsa-miR-222-3p GRB10 -0.233673471709747 0.726651775432807 -0.205639469828889 0.666151118942152 miRNAWalker2_validate -0.139329267033803 0.000663551907010256 NA NA NA hsa-miR-107 GREM2 -0.289737369453023 0.769655185893943 0.545447047262879 0.24874844075317 PITA;miRanda;miRNATAP -0.326557033802583 0.0197028703366794 NA NA NA hsa-miR-140-3p GRHL2 -0.105651799466207 0.9077781740714 -0.121964332294207 0.816948639211559 MirTarget;PITA -0.231860596709879 0.0004439817875923 NA NA NA hsa-miR-15b-5p GRM7 0.251826642099145 0.790709218602499 -0.62779723663181 0.23049165718907 MirTarget;miRNATAP -0.538785108020064 0.000334092274701787 NA NA NA hsa-miR-140-3p GSK3A -0.105651799466207 0.9077781740714 -0.0635174447391869 0.919293004596672 PITA -0.127585225294829 0.000409671022218889 NA NA NA hsa-miR-214-3p GSTM2 0.0312810611346688 0.952640488671912 0.178404406146088 0.71708042042517 mirMAP -0.163006615498704 0.00036808773541537 NA NA NA hsa-miR-150-5p GSTM3 -0.00683324482969283 0.994067057151257 -0.058828001311694 0.902691633028036 mirMAP -0.198962421601053 7.99236273943993e-06 NA NA NA hsa-miR-107 GSTM5 -0.289737369453023 0.769655185893943 -0.539613076086012 0.230113514454763 miRanda -0.616301751474425 3.14299394298076e-06 NA NA NA hsa-miR-186-5p GSTM5 -0.246324984406451 0.701310703524093 -0.539613076086012 0.230113514454763 mirMAP -0.398047714613038 0.00489256620853982 NA NA NA hsa-miR-26b-5p GSTM5 0.16143906971203 0.790777916193478 -0.539613076086012 0.230113514454763 mirMAP -0.309371772058097 0.0348532051928138 NA NA NA hsa-miR-320b GSTM5 0.298760649675195 0.700446828731538 -0.539613076086012 0.230113514454763 mirMAP -0.1968384092596 0.0484398334168183 NA NA NA hsa-miR-221-3p GTF2E1 -0.261179092929062 0.744019631321393 -0.0457926616512019 0.903172294017755 miRNAWalker2_validate -0.108990800110252 5.98907318831052e-06 NA NA NA hsa-miR-222-3p GTF3C4 -0.233673471709747 0.726651775432807 -0.187370685144983 0.655496554038728 mirMAP -0.119545443237958 0.000187795421631742 NA NA NA hsa-miR-140-3p GTPBP3 -0.105651799466207 0.9077781740714 -0.0715205429104717 0.865101123343378 MirTarget -0.147778873629085 0.00157869819249191 NA NA NA hsa-miR-181c-5p GTSE1 -0.262596734125804 0.645471285705202 -0.251900492376796 0.526069160653623 MirTarget -0.220186872078177 1.14767303631063e-05 NA NA NA hsa-miR-181d-5p GTSE1 -0.294264170071504 0.604392929232074 -0.251900492376796 0.526069160653623 MirTarget -0.124080787294619 0.00531708701492224 NA NA NA hsa-miR-320c GUCY1B3 0.092255964601645 0.785539881268253 0.296234140665735 0.568297762752824 miRanda -0.147141124172387 0.0330402976557922 NA NA NA hsa-miR-320d GUCY1B3 0.353471568894745 0.357430999251147 0.296234140665735 0.568297762752824 miRanda -0.134955480798064 0.0123013998704955 NA NA NA hsa-miR-429 GUCY1B3 -0.596617415946644 0.128967410286089 0.296234140665735 0.568297762752824 miRanda -0.13642744355301 0.0202661354109234 NA NA NA hsa-let-7f-1-3p GULP1 0.131753980154284 0.686438107181988 -0.191568697963024 0.661700299395527 MirTarget;mirMAP -0.155177023325996 0.0416844791262246 NA NA NA hsa-miR-15b-3p GULP1 0.0805005446828257 0.846317514546419 -0.191568697963024 0.661700299395527 mirMAP -0.320258838700617 0.000126998422622854 NA NA NA hsa-miR-192-5p GULP1 -0.00281508349767456 0.99638352116085 -0.191568697963024 0.661700299395527 miRNAWalker2_validate -0.255761710152046 6.0755851462647e-05 NA NA NA hsa-miR-30e-3p GULP1 0.202355073367528 0.857417040078429 -0.191568697963024 0.661700299395527 mirMAP -0.231842213779019 0.0346826614204686 NA NA NA hsa-miR-374b-5p GULP1 -0.267096820650889 0.470048956816 -0.191568697963024 0.661700299395527 mirMAP -0.168171970268791 0.023235916355862 NA NA NA hsa-miR-27a-3p GXYLT1 0.309634509674364 0.703724209648479 0.0309454668772027 0.939527543534158 miRNATAP -0.114761311193716 0.00313416614408988 NA NA NA hsa-miR-107 GYPC -0.289737369453023 0.769655185893943 0.201621761713326 0.661673470535131 miRanda -0.216696946806115 0.00222254075824663 NA NA NA hsa-miR-128-3p H3F3C -0.0364518492233463 0.95841670253784 0.164197212368519 0.452288039469947 MirTarget -0.14333785027558 0.0201399634924399 NA NA NA hsa-miR-222-3p HAUS8 -0.233673471709747 0.726651775432807 -0.0907218799412601 0.798031922786145 miRNAWalker2_validate -0.159782576890934 0.000187818741677209 NA NA NA hsa-miR-27a-3p HCN4 0.309634509674364 0.703724209648479 -0.070999348466067 0.890135374463602 miRNATAP -0.329499124212177 0.0130473899228146 NA NA NA hsa-miR-22-3p HDAC4 0.0468440219945929 0.967778504781139 -0.275592349037378 0.542250148863867 miRNAWalker2_validate;miRTarBase;miRNATAP -0.123918964828771 0.00279384427648962 20842113 Furthermore histone deacetylase 4 HDAC4 known to have critical roles in cancer development was proved to be directly targeted and regulated by miR-22; Furthermore HDAC4 was upregulated in miR-22-downregulated HCC tissues suggesting that downregulation of miR-22 might participate in HCC carcinogenesis and progression through potentiation of HDAC4 expression progression;tumorigenesis liver cancer hsa-miR-107 HEBP1 -0.289737369453023 0.769655185893943 -0.15117497195037 0.75605907650992 miRanda -0.146534297817916 0.000631580711404125 NA NA NA hsa-miR-214-3p HES6 0.0312810611346688 0.952640488671912 0.148676660737039 0.712519544282552 mirMAP -0.105312388449972 0.0236761904711796 NA NA NA hsa-miR-128-3p HIC1 -0.0364518492233463 0.95841670253784 -0.0344480987639861 0.931632461442992 MirTarget -0.199744745358745 0.0191302863400068 NA NA NA hsa-miR-150-5p HIF3A -0.00683324482969283 0.994067057151257 0.146506883407749 0.810382163502263 mirMAP -0.162607229788463 0.0262204572560258 NA NA NA hsa-miR-98-5p HIF3A -0.0484028619275874 0.910781316485549 0.146506883407749 0.810382163502263 mirMAP -0.392738832339778 9.85540640707651e-05 NA NA NA hsa-miR-127-3p HINT2 0.231539840651733 0.822108193638849 0.144304126286809 0.749472380534025 miRanda -0.164690368037114 1.26844395865931e-06 NA NA NA hsa-miR-589-5p HIPK1 -0.181894068226246 0.778993585147379 -0.418897142801792 0.456624759064531 miRNATAP -0.141804253210391 0.000225921897457853 NA NA NA hsa-miR-15b-5p HIPK2 0.251826642099145 0.790709218602499 -0.287025072753059 0.646492190124924 miRNATAP -0.133580120011527 0.024610961247001 NA NA NA hsa-miR-27a-3p HIPK2 0.309634509674364 0.703724209648479 -0.287025072753059 0.646492190124924 miRNAWalker2_validate;miRNATAP -0.14304582862511 0.00420208546643711 20646448;20624637 2 A2780/Taxol cells transfection with inhibitors of miR-27a showed that the levels of MDR1 mRNA was decreased by 39% P-gp protein level 26+/-5% decreased than that in the NC group 43+/-7% HIPK2 protein level 30+/-6% increased than that in the NC group 19+/-4% the 50% inhibition concentration 0.5 micromol/L was less than that in the NC group 6.8 micromol/L apoptosis rate 32.5+/-3.6% was higher than that in the NC group 5.6+/-2.1% and there were significant differences between two groups all P<0.05; The expression of miR-27a is upregulated in A2780/Taxol cells which may regulate MDR1 and P-gp expression by targeting HIPK2;MiR 27a modulates MDR1/P glycoprotein expression by targeting HIPK2 in human ovarian cancer cells; Transfection of A2780/Taxol cells with the inhibitors of miR-27a decreased the expression of MDR1 mRNA and P-gp protein increased HIPK2 protein expression enhanced the sensitivity of A2780/taxol cells to paclitaxel increased paclitaxel-induced apoptosis and the fluorescence intensity of intracellular Rh-123; The deregulation of miR-27a may be involved in the development of drug resistance regulating the expression of MDR1/P-gp at least in part by targeting HIPK2 in ovarian cancer cells ;drug resistance ovarian cancer;ovarian cancer hsa-miR-221-3p HIST2H2AC -0.261179092929062 0.744019631321393 0.288073545766011 0.398519682365324 miRNAWalker2_validate -0.212608918092888 0.00294169058639804 NA NA NA hsa-let-7d-5p HLF 0.0119393569456978 0.988390093874148 -0.406565963148618 0.262525428348243 miRNATAP -0.224131539419137 0.0234477310828607 NA NA NA hsa-let-7f-1-3p HLF 0.131753980154284 0.686438107181988 -0.406565963148618 0.262525428348243 mirMAP -0.184284499412368 0.0195888372836567 NA NA NA hsa-miR-106b-5p HLF -0.3941595235172 0.389635342155994 -0.406565963148618 0.262525428348243 MirTarget;miRNATAP -0.227817179367067 0.0223343338126764 NA NA NA hsa-miR-107 HLF -0.289737369453023 0.769655185893943 -0.406565963148618 0.262525428348243 PITA;miRNATAP -0.236371987575107 0.0258972032101061 NA NA NA hsa-miR-186-5p HLF -0.246324984406451 0.701310703524093 -0.406565963148618 0.262525428348243 mirMAP -0.242196687573856 0.0308850939407026 NA NA NA hsa-miR-196b-5p HLF 0.7434875713555 0.299144919628083 -0.406565963148618 0.262525428348243 miRNATAP -0.117675483530156 0.000256474230788922 NA NA NA hsa-miR-27a-5p HLF -0.00797189811576748 0.985270279280688 -0.406565963148618 0.262525428348243 MirTarget -0.189826516173887 0.00427147687847068 NA NA NA hsa-miR-616-5p HLF -0.321509218120179 0.271446046739636 -0.406565963148618 0.262525428348243 mirMAP -0.218310937587569 0.00278176517867565 NA NA NA hsa-miR-744-3p HLF 0.111079149628683 0.794388290953005 -0.406565963148618 0.262525428348243 MirTarget -0.145396425009191 0.0266683434442682 NA NA NA hsa-miR-769-3p HLF 0.0256482406355687 0.939929956150103 -0.406565963148618 0.262525428348243 PITA;miRNATAP -0.193211068821062 0.0322090127157052 NA NA NA hsa-miR-93-5p HLF -0.375078982324499 0.732311284477601 -0.406565963148618 0.262525428348243 MirTarget;miRNATAP -0.330359970382059 0.000466084993493276 NA NA NA hsa-miR-940 HLF 0.19340062942074 0.679749292292113 -0.406565963148618 0.262525428348243 MirTarget;miRNATAP -0.338340454333191 4.52656433272376e-07 NA NA NA hsa-miR-942-5p HLF -0.766562590119066 0.0293037013994827 -0.406565963148618 0.262525428348243 MirTarget -0.238073420049438 0.00176268578229293 NA NA NA hsa-miR-221-3p HMBOX1 -0.261179092929062 0.744019631321393 0.0325822504351332 0.903694982022734 MirTarget;miRNATAP -0.109238318928543 0.00858497785978992 NA NA NA hsa-miR-222-3p HMBOX1 -0.233673471709747 0.726651775432807 0.0325822504351332 0.903694982022734 MirTarget;miRNATAP -0.114630334042755 0.00540773918139505 NA NA NA hsa-miR-125a-5p HMBS -0.00666761469427968 0.994891296705929 0.148540379308495 0.735519061208647 miRanda -0.283773696065609 2.41352460670813e-06 NA NA NA hsa-miR-15b-5p HMGA2 0.251826642099145 0.790709218602499 -0.495870455398845 0.474353706194245 MirTarget -0.565202280018764 0.00246420417765114 NA NA NA hsa-miR-98-5p HMGA2 -0.0484028619275874 0.910781316485549 -0.495870455398845 0.474353706194245 miRNAWalker2_validate;miRTarBase;MirTarget -0.3656549955416 0.00218393467641425 17222355;23700794 Here we report that HMGA2 expression in head and neck squamous cell carcinoma HNSCC cells is regulated in part by miRNA-98 miR-98;MicroRNA 98 sensitizes cisplatin resistant human lung adenocarcinoma cells by up regulation of HMGA2; MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells; We found that elevated expression of miR-98 led to a higher sensitivity of A549/DDP cells to cisplatin and the protein level of HMGA2 was clearly up-regulated in both A549/DDP and A549 cells by miR-98; We for the first time demonstrated that the expression of miR-98 increases cells spontaneous apoptosis and sensitizes cells to cisplatin at least in part via HMGA2 up-regulation ; head and neck cancer;lung cancer hsa-miR-148a-3p HMGB1 -0.324144803192141 0.746264759480212 0.0376071736611054 0.957155680367252 miRNAWalker2_validate -0.127033208854852 7.27023134780739e-06 NA NA NA hsa-miR-22-3p HMGB1 0.0468440219945929 0.967778504781139 0.0376071736611054 0.957155680367252 miRNAWalker2_validate -0.112621671900166 4.10533914896381e-05 24609901;24752578 However possibly as a compensatory effect miR-22 was also upregulated during the chemotherapy and the overexpressed miR-22 targeted the 3' UTR of HMGB1 and inhibits the HMGB1-promoted autophagy; Our study suggests a complexity in the regulation of autophagy by miR-22 and HMGB1 during chemotherapy resistance in osteosarcoma;In this study we determined the targeting role of miR-22 to HMGB1 and the regulation of miR-22 on the HMGB1-mediated cell autophagy and on the cell proliferation migration and invasion of osteosarcoma cells drug resistance; sarcoma;sarcoma hsa-miR-125a-5p HMGB3 -0.00666761469427968 0.994891296705929 0.0159576216206698 0.976144823519991 PITA;miRNATAP -0.232528496303642 0.000977118284842133 NA NA NA hsa-miR-125b-5p HMGB3 0.0074438975183444 0.994154663318355 0.0159576216206698 0.976144823519991 miRNATAP -0.100461613090038 0.0151450460666195 NA NA NA hsa-miR-26a-5p HMGB3 0.0483232931294246 0.955218190818435 0.0159576216206698 0.976144823519991 mirMAP -0.307271842418662 2.63327669963975e-08 NA NA NA hsa-miR-26b-5p HMGB3 0.16143906971203 0.790777916193478 0.0159576216206698 0.976144823519991 mirMAP -0.174379873805629 0.00181519039015162 NA NA NA hsa-miR-30a-5p HMGB3 -0.163405499812159 0.87950357765238 0.0159576216206698 0.976144823519991 miRNATAP -0.119713334377223 0.00150182186065653 NA NA NA hsa-miR-30c-5p HMGB3 -0.183013966936985 0.833177718550926 0.0159576216206698 0.976144823519991 miRNATAP -0.165432825156629 0.00108915536334058 NA NA NA hsa-miR-320c HMGB3 0.092255964601645 0.785539881268253 0.0159576216206698 0.976144823519991 miRanda -0.129894981848928 0.00083114610631688 NA NA NA hsa-miR-127-3p HMGCL 0.231539840651733 0.822108193638849 0.0909133155599902 0.851479192791536 miRanda -0.168006519273437 9.49843480411152e-11 NA NA NA hsa-miR-140-3p HMGN1 -0.105651799466207 0.9077781740714 0.0843399498957567 0.894287532642448 miRNATAP -0.121406570810038 0.000356768507897872 NA NA NA hsa-miR-140-3p HMGN3 -0.105651799466207 0.9077781740714 0.173834628633814 0.760448721379763 PITA;miRNATAP -0.152515466420663 0.000709178176066654 NA NA NA hsa-miR-214-3p HMGN3 0.0312810611346688 0.952640488671912 0.173834628633814 0.760448721379763 miRNATAP -0.127699729283976 1.02249859521777e-06 NA NA NA hsa-miR-106b-5p HN1 -0.3941595235172 0.389635342155994 0.00288424131847265 0.995993763808415 miRNAWalker2_validate;miRNATAP -0.116828312475223 0.0262235847870078 NA NA NA hsa-miR-150-5p HNF1A -0.00683324482969283 0.994067057151257 -0.599780281038367 0.0463852812396608 mirMAP -0.198864168768169 1.57332747748628e-06 NA NA NA hsa-miR-15b-5p HNF1A 0.251826642099145 0.790709218602499 -0.599780281038367 0.0463852812396608 mirMAP -0.289445654410361 0.0014872298899797 NA NA NA hsa-miR-24-3p HNF1B 0.0408517902063537 0.966828370841971 -0.542897650268929 0.527557098310134 MirTarget -0.955672932084817 0.000158831950182672 NA NA NA hsa-miR-197-3p HNRNPA1 0.0240027695773914 0.981971058073739 0.324357344981395 0.646474695150591 miRNAWalker2_validate -0.107511652466325 0.00400720611419532 NA NA NA hsa-miR-107 HOPX -0.289737369453023 0.769655185893943 0.312349411044829 0.499613152004287 miRanda -0.215543808581572 0.0162612185420359 NA NA NA hsa-miR-130a-3p HOXA5 -0.0153771286384572 0.977389403395331 2.32161089735034 0.000482168833757088 miRNAWalker2_validate;miRTarBase;miRNATAP -0.564422456993243 0.00137306398287567 NA NA NA hsa-miR-26b-5p HOXA5 0.16143906971203 0.790777916193478 2.32161089735034 0.000482168833757088 miRNATAP -0.584242606278799 0.0078389633547291 NA NA NA hsa-miR-320c HOXA5 0.092255964601645 0.785539881268253 2.32161089735034 0.000482168833757088 miRNATAP -0.364954717813192 0.017146131853915 NA NA NA hsa-miR-320d HOXA5 0.353471568894745 0.357430999251147 2.32161089735034 0.000482168833757088 miRNATAP -0.270868654473828 0.0237753551681757 NA NA NA hsa-miR-27a-3p HOXC11 0.309634509674364 0.703724209648479 0.0406709827527383 0.955573595094228 miRNATAP -0.365338289322512 0.017688783785241 NA NA NA hsa-miR-214-3p HOXC4 0.0312810611346688 0.952640488671912 0.570064880006255 0.26273503625506 miRNATAP -0.14326585233287 0.0132546013433304 NA NA NA hsa-miR-27b-3p HOXC6 0.306246927737414 0.735781270461428 0.294273689840116 0.455456897210488 miRNATAP -0.234682990550687 0.0157120041514026 NA NA NA hsa-miR-361-5p HOXC6 -0.278147578656315 0.728553069590798 0.294273689840116 0.455456897210488 miRanda -0.323049261766966 0.0169215871367437 NA NA NA hsa-miR-150-5p HPSE2 -0.00683324482969283 0.994067057151257 1.04276198085754 0.183067657657017 MirTarget -0.347352216867203 0.000300250703674567 NA NA NA hsa-miR-15b-5p HPSE2 0.251826642099145 0.790709218602499 1.04276198085754 0.183067657657017 MirTarget -0.612751379670714 0.00349892342779719 NA NA NA hsa-miR-214-3p HPSE2 0.0312810611346688 0.952640488671912 1.04276198085754 0.183067657657017 MirTarget -0.247103395065671 0.024134354605581 NA NA NA hsa-miR-129-5p HRH1 0.417083435812871 0.454236109516901 0.426131827672527 0.37765431258365 miRanda -0.197264910194325 1.98692907369362e-05 NA NA NA hsa-miR-130a-3p HRH1 -0.0153771286384572 0.977389403395331 0.426131827672527 0.37765431258365 mirMAP -0.190016730477969 0.0170866024741061 NA NA NA hsa-miR-130b-3p HRH1 -0.246958204594817 0.524070870130445 0.426131827672527 0.37765431258365 mirMAP -0.15551358483471 0.0422447804640711 NA NA NA hsa-miR-324-5p HRH1 -0.358991607952497 0.499732551112182 0.426131827672527 0.37765431258365 miRanda -0.318777633888739 5.76286898341649e-05 NA NA NA hsa-miR-335-3p HRH1 0.0738544228922926 0.89349398283313 0.426131827672527 0.37765431258365 mirMAP -0.134067013406102 0.019210520428967 NA NA NA hsa-miR-616-5p HRH1 -0.321509218120179 0.271446046739636 0.426131827672527 0.37765431258365 mirMAP -0.127880220335564 0.0411671252316666 NA NA NA hsa-miR-9-5p HRH1 0.029299723902132 0.964227616086639 0.426131827672527 0.37765431258365 mirMAP -0.200973802545201 2.67868273511117e-07 NA NA NA hsa-miR-940 HRH1 0.19340062942074 0.679749292292113 0.426131827672527 0.37765431258365 PITA -0.242676173010619 2.5882226282175e-05 NA NA NA hsa-miR-222-3p HSPA14 -0.233673471709747 0.726651775432807 -0.0686296948376199 0.877982742102929 miRNAWalker2_validate -0.140220146429936 2.11317164961284e-06 NA NA NA hsa-miR-155-5p HSPA4L -0.320577372003167 0.673183036961734 0.169410268424575 0.62991687462233 miRNAWalker2_validate -0.208186981936184 0.00181189087621678 NA NA NA hsa-miR-320c HSPA4L 0.092255964601645 0.785539881268253 0.169410268424575 0.62991687462233 miRanda -0.186173731838148 0.0172527072776267 NA NA NA hsa-miR-98-5p HSPB7 -0.0484028619275874 0.910781316485549 0.680516360685846 0.0824688640822675 miRNAWalker2_validate -0.142505448745325 0.0488960776237782 NA NA NA hsa-miR-214-3p HSPD1 0.0312810611346688 0.952640488671912 -0.102889357474595 0.886223639469787 miRNAWalker2_validate -0.109200704145466 4.15357488678914e-07 NA NA NA hsa-miR-15b-5p HSPG2 0.251826642099145 0.790709218602499 -0.0549567717778192 0.945061296685726 MirTarget -0.138457976550672 0.0429957992481835 NA NA NA hsa-miR-127-3p HTR3A 0.231539840651733 0.822108193638849 0.408755916833218 0.590337544234306 miRanda -0.252636662940679 0.0395516167599594 NA NA NA hsa-miR-139-5p HYDIN -0.0625698939687087 0.914810329989088 -0.293171348826773 0.500530184320928 miRanda -0.160743868264919 0.0478765051008873 NA NA NA hsa-miR-192-5p ID1 -0.00281508349767456 0.99638352116085 0.0803259978956197 0.879121706076722 miRNAWalker2_validate -0.275692293942321 2.20079373934527e-05 NA NA NA hsa-miR-26b-5p ID1 0.16143906971203 0.790777916193478 0.0803259978956197 0.879121706076722 miRNAWalker2_validate -0.368154333213682 0.00117580047462598 NA NA NA hsa-miR-29a-3p ID1 0.203872357562561 0.859946061784007 0.0803259978956197 0.879121706076722 MirTarget -0.355039564255987 2.06475880246305e-05 NA NA NA hsa-miR-29b-3p ID1 -0.249746665931503 0.558208927436524 0.0803259978956197 0.879121706076722 MirTarget -0.209704228751168 0.000403790340992378 24662327;22249264 Id 1 a protein repressed by miR 29b facilitates the TGFβ1 induced epithelial mesenchymal transition in human ovarian cancer cells;Incubation of lung cancer cells with the Src inhibitor saracatinib led to the upregulation of several miRNAs including miR-29b which was the most highly upregulated miRNA with predicted binding to the ID1 3'-untranslated region UTR; Luciferase reporter assays confirmed direct binding of miR-29b to the ID1 3'-UTR; Expression of miR-29b suppressed ID1 levels and significantly reduced migration and invasion ; ovarian cancer;lung cancer hsa-miR-29c-3p ID1 0.042533372292219 0.941334605544826 0.0803259978956197 0.879121706076722 MirTarget -0.260685465888987 0.000129665517714482 NA NA NA hsa-miR-107 ID2 -0.289737369453023 0.769655185893943 -0.035243584091373 0.948581601574187 miRanda -0.284955473257002 8.36366764569542e-06 NA NA NA hsa-miR-27a-3p ID2 0.309634509674364 0.703724209648479 -0.035243584091373 0.948581601574187 MirTarget;miRNATAP -0.15734584861054 0.0052530037383378 NA NA NA hsa-miR-127-3p IDO1 0.231539840651733 0.822108193638849 -0.399635110883189 0.532606564069925 miRanda -0.313610820173607 0.00135375917718075 NA NA NA hsa-miR-107 IDS -0.289737369453023 0.769655185893943 0.00659697334470977 0.991911950215013 miRanda -0.110406419437008 0.011872595935368 NA NA NA hsa-miR-181a-2-3p IFI44L 0.158138593715531 0.867246344226279 -0.370218423979752 0.569780354422906 MirTarget -0.266301336059608 0.00274532562830521 NA NA NA hsa-miR-370-3p IFIT1 0.098308557757175 0.854848187015064 -0.25463695070182 0.702479614656268 MirTarget -0.25771122746667 2.91832206111111e-06 NA NA NA hsa-miR-92a-1-5p IFIT1 -0.0244017451020895 0.958247318021666 -0.25463695070182 0.702479614656268 MirTarget -0.29486634263147 0.000998054215937142 NA NA NA hsa-miR-199a-5p IFRD1 0.248253058498817 0.7461266806999 -0.236679318354249 0.612615024611475 miRanda -0.10877526146365 7.46279951384449e-05 NA NA NA hsa-miR-485-3p IFRD1 0.260493747772693 0.658365017969425 -0.236679318354249 0.612615024611475 MirTarget -0.122959918289623 1.16671368220523e-07 NA NA NA hsa-miR-493-5p IFRD1 0.446650879308971 0.32421223482789 -0.236679318354249 0.612615024611475 MirTarget -0.116711294511737 9.15009586244343e-06 NA NA NA hsa-miR-150-5p IGDCC3 -0.00683324482969283 0.994067057151257 -0.131145753107458 0.8547106150508 mirMAP -0.574765877794648 2.31687625271158e-09 NA NA NA hsa-miR-98-5p IGDCC3 -0.0484028619275874 0.910781316485549 -0.131145753107458 0.8547106150508 MirTarget -0.454800217661095 0.000875784818487051 NA NA NA hsa-miR-107 IGDCC4 -0.289737369453023 0.769655185893943 -0.196249749405944 0.598311767163085 miRanda -0.276045351833311 0.00337169607061605 NA NA NA hsa-miR-148a-3p IGDCC4 -0.324144803192141 0.746264759480212 -0.196249749405944 0.598311767163085 miRNATAP -0.223917620075446 0.00273848398756855 NA NA NA hsa-miR-98-5p IGDCC4 -0.0484028619275874 0.910781316485549 -0.196249749405944 0.598311767163085 MirTarget -0.158125405490403 0.0113010517829518 NA NA NA hsa-miR-139-5p IGF1R -0.0625698939687087 0.914810329989088 0.181844503809824 0.77996203041897 miRNAWalker2_validate;miRTarBase;MirTarget;PITA -0.174106272129585 0.00896722597597466 26097570 Furthermore we identified insulin-like growth factor 1 receptor IGF1R as a target of miR-139-5p and miR-139-5p function as a tumor suppressor via targeting IGF1R in NSCLC; Our results indicated that miR-139-5p acts as a tumor suppressor in NSCLC partially via down-regulating IGF1R expression lung squamous cell cancer hsa-miR-140-3p IGF1R -0.105651799466207 0.9077781740714 0.181844503809824 0.77996203041897 mirMAP -0.154595141171486 0.0396588059668609 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-150-5p IGF1R -0.00683324482969283 0.994067057151257 0.181844503809824 0.77996203041897 mirMAP -0.18117811369085 2.23430163003899e-06 NA NA NA hsa-miR-15b-5p IGF1R 0.251826642099145 0.790709218602499 0.181844503809824 0.77996203041897 miRNATAP -0.317779005119476 0.000151662468233773 NA NA NA hsa-miR-27a-3p IGF1R 0.309634509674364 0.703724209648479 0.181844503809824 0.77996203041897 mirMAP -0.163745983586904 0.0215914331883283 NA NA NA hsa-miR-98-5p IGF1R -0.0484028619275874 0.910781316485549 0.181844503809824 0.77996203041897 MirTarget -0.110364533529799 0.0413819473384427 NA NA NA hsa-miR-148a-3p IGF2 -0.324144803192141 0.746264759480212 -0.00189647616083555 0.998651871055033 mirMAP -0.576587947047826 0.00424891563780717 NA NA NA hsa-miR-98-5p IGF2BP1 -0.0484028619275874 0.910781316485549 -0.284459156903399 0.684218447229109 MirTarget -0.301883147850632 0.0289552696686835 NA NA NA hsa-miR-26b-5p IGFBP4 0.16143906971203 0.790777916193478 0.298257105642525 0.679607818620953 miRNAWalker2_validate -0.162753447388146 0.0305324193203541 NA NA NA hsa-miR-375 IGFBP4 -0.989394125724925 0.312728638150002 0.298257105642525 0.679607818620953 miRanda -0.102646645469805 9.98832626827924e-05 NA NA NA hsa-miR-101-3p IGFBP5 -0.0149915187591869 0.981999725022451 0.299654077950189 0.701540618740945 miRNATAP -0.266907255247369 0.00169985182144545 NA NA NA hsa-miR-141-5p IGFBP5 -0.41673325588269 0.491200782452983 0.299654077950189 0.701540618740945 mirMAP -0.169500156695674 0.00402199681373694 NA NA NA hsa-miR-146a-5p IGFBP5 -0.129284021174742 0.817914855859866 0.299654077950189 0.701540618740945 MirTarget -0.185928187990784 0.000470404249141552 NA NA NA hsa-miR-15b-3p IGFBP5 0.0805005446828257 0.846317514546419 0.299654077950189 0.701540618740945 mirMAP -0.188073470848472 0.0203089031593436 NA NA NA hsa-miR-17-5p IGFBP5 -0.643066792834501 0.320674049526638 0.299654077950189 0.701540618740945 miRNAWalker2_validate -0.174540848851882 0.019068994345863 NA NA NA hsa-miR-200a-5p IGFBP5 -0.38041643229106 0.656858548422971 0.299654077950189 0.701540618740945 mirMAP -0.230845981883283 0.000418592252181158 NA NA NA hsa-miR-203a-3p IGFBP5 -0.472290269049916 0.632432558722238 0.299654077950189 0.701540618740945 MirTarget -0.155849444151383 0.00133150164731924 NA NA NA hsa-miR-224-5p IGFBP5 -0.143123534787342 0.827443367193551 0.299654077950189 0.701540618740945 mirMAP -0.213496026166072 7.37773903032539e-08 NA NA NA hsa-miR-30b-3p IGFBP5 -0.231361964211179 0.496038769366155 0.299654077950189 0.701540618740945 MirTarget -0.187704044593756 0.0198763595222373 NA NA NA hsa-miR-616-5p IGFBP5 -0.321509218120179 0.271446046739636 0.299654077950189 0.701540618740945 mirMAP -0.206671510008087 0.00225684416606791 NA NA NA hsa-miR-625-5p IGFBP5 -0.725005787172203 0.0605502864822602 0.299654077950189 0.701540618740945 mirMAP -0.175352229690984 0.00167572290257323 NA NA NA hsa-miR-629-3p IGFBP5 -0.455149050361454 0.209212127982437 0.299654077950189 0.701540618740945 mirMAP;miRNATAP -0.23282212990563 0.00157762818754322 NA NA NA hsa-miR-942-5p IGFBP5 -0.766562590119066 0.0293037013994827 0.299654077950189 0.701540618740945 MirTarget -0.144544807630826 0.0415840399382123 NA NA NA hsa-miR-27a-3p IGLON5 0.309634509674364 0.703724209648479 0.721021227238998 0.265049722736949 MirTarget;miRNATAP -0.3319549314825 0.0490084742440482 NA NA NA hsa-miR-15b-5p IGSF9B 0.251826642099145 0.790709218602499 0.3027723021916 0.563453652432104 mirMAP -0.365261895269685 0.022964485998494 NA NA NA hsa-miR-150-5p IHH -0.00683324482969283 0.994067057151257 -0.239196523021247 0.741788210234923 miRNATAP -0.557858949959687 5.3698418143045e-10 NA NA NA hsa-miR-15b-5p IHH 0.251826642099145 0.790709218602499 -0.239196523021247 0.741788210234923 MirTarget;miRNATAP -0.686474802966716 0.000598466283027087 NA NA NA hsa-miR-139-5p IKBKB -0.0625698939687087 0.914810329989088 -0.241085468681219 0.630606951636123 miRanda -0.11477273652595 0.00111240774729446 NA NA NA hsa-miR-148a-3p IL17RD -0.324144803192141 0.746264759480212 -0.0837567037988727 0.870962136224886 miRNATAP -0.163603919776108 0.0110307354480661 NA NA NA hsa-miR-150-5p IL17RD -0.00683324482969283 0.994067057151257 -0.0837567037988727 0.870962136224886 mirMAP -0.171106826170488 7.11913006567918e-06 NA NA NA hsa-miR-22-3p IL17RD 0.0468440219945929 0.967778504781139 -0.0837567037988727 0.870962136224886 MirTarget;miRNATAP -0.300302259370387 9.64911303374779e-07 NA NA NA hsa-miR-129-5p IL20RA 0.417083435812871 0.454236109516901 0.477836552309073 0.265262389102312 miRanda -0.165918772736879 0.00269383875219446 NA NA NA hsa-miR-338-3p IL20RA -0.107178830331044 0.818042702366464 0.477836552309073 0.265262389102312 miRanda -0.270099872545004 5.64646907306169e-06 NA NA NA hsa-miR-374b-5p IL20RA -0.267096820650889 0.470048956816 0.477836552309073 0.265262389102312 mirMAP -0.201145959107893 0.00975416979275161 NA NA NA hsa-miR-296-3p IL33 0.305371903227786 0.470342914513253 0.305527004185405 0.42669162914888 miRanda -0.202451432067068 0.00126211585242541 NA NA NA hsa-miR-129-5p IL7 0.417083435812871 0.454236109516901 0.418405236176588 0.246953625046806 miRanda -0.223926958947233 4.06194397118041e-05 NA NA NA hsa-miR-335-3p IL7 0.0738544228922926 0.89349398283313 0.418405236176588 0.246953625046806 mirMAP -0.148070891409457 0.0283335222319975 NA NA NA hsa-miR-429 IL7 -0.596617415946644 0.128967410286089 0.418405236176588 0.246953625046806 miRanda -0.147487945747984 0.0332212802143426 NA NA NA hsa-miR-139-5p ILDR1 -0.0625698939687087 0.914810329989088 0.0445237863089369 0.915777291538141 miRanda -0.138247620492926 0.00459129190284946 NA NA NA hsa-miR-221-3p INA -0.261179092929062 0.744019631321393 -0.389856424611482 0.485952218559766 MirTarget;miRNATAP -0.441784902604437 0.000623856859846905 NA NA NA hsa-miR-222-3p INA -0.233673471709747 0.726651775432807 -0.389856424611482 0.485952218559766 MirTarget -0.443870764233659 0.000529697200786564 NA NA NA hsa-miR-125a-3p ING4 0.124026360619668 0.800539414590835 0.08563728606146 0.865248448223296 miRanda -0.258711901311597 2.85192311134023e-06 NA NA NA hsa-miR-214-3p ING4 0.0312810611346688 0.952640488671912 0.08563728606146 0.865248448223296 miRTarBase -0.117834462627946 1.14759075839732e-05 NA NA NA hsa-miR-330-3p ING4 -0.1562229971038 0.692313620862782 0.08563728606146 0.865248448223296 PITA;miRNATAP -0.192559391190381 9.58733892659734e-07 NA NA NA hsa-miR-342-5p ING4 -0.19757735088008 0.634667447344581 0.08563728606146 0.865248448223296 miRNATAP -0.107773906816067 0.0259164742263535 NA NA NA hsa-miR-491-5p ING4 -0.181856111353416 0.55955455770555 0.08563728606146 0.865248448223296 miRanda -0.145363739473218 0.000883950688736059 NA NA NA hsa-miR-769-5p ING4 -0.13630313069917 0.742095588741811 0.08563728606146 0.865248448223296 miRNATAP -0.126879673251626 0.0175038025025298 NA NA NA hsa-miR-150-5p ING5 -0.00683324482969283 0.994067057151257 -0.442327758599586 0.29264132475739 mirMAP -0.12846262886785 1.12672813154626e-08 NA NA NA hsa-miR-27a-3p ING5 0.309634509674364 0.703724209648479 -0.442327758599586 0.29264132475739 MirTarget;miRNATAP -0.123214071529203 0.00343673864786576 NA NA NA hsa-miR-107 INMT -0.289737369453023 0.769655185893943 0.227986011911441 0.536094203946461 miRanda -0.290214657869074 0.00565469334423472 NA NA NA hsa-miR-139-5p INPP5J -0.0625698939687087 0.914810329989088 -0.45205349346122 0.193882293272043 miRanda -0.145130011632209 0.0132453143404039 NA NA NA hsa-let-7b-5p INTS7 0.396604576702067 0.783406687058469 -0.0511488543024363 0.907234319882538 miRNAWalker2_validate -0.16222880663971 1.14454644887191e-07 NA NA NA hsa-miR-222-3p IPO5 -0.233673471709747 0.726651775432807 -0.0469735621627194 0.943180179467306 miRNAWalker2_validate -0.138431473786496 2.6999922065134e-05 NA NA NA hsa-miR-221-3p IPO9 -0.261179092929062 0.744019631321393 -0.0424977885749938 0.944515767790151 mirMAP -0.135710374620127 3.16220925948726e-07 NA NA NA hsa-miR-222-3p IPO9 -0.233673471709747 0.726651775432807 -0.0424977885749938 0.944515767790151 mirMAP -0.141870862704971 6.59493928708857e-08 NA NA NA hsa-miR-330-3p IQCH -0.1562229971038 0.692313620862782 -0.0382174435903844 0.87649550706356 MirTarget;miRNATAP -0.179804458650546 0.000708758828859565 NA NA NA hsa-miR-342-3p IQCH -0.233020179388453 0.739959578456401 -0.0382174435903844 0.87649550706356 miRanda -0.131284814636913 0.0386508683609496 NA NA NA hsa-miR-365a-5p IQCK -0.0793405119778852 0.800861924562577 0.0275250441159693 0.952709965976671 MirTarget -0.111365835480716 0.00700756323491676 NA NA NA hsa-miR-107 IRF2BP1 -0.289737369453023 0.769655185893943 -0.0851195783672098 0.874408687303578 miRNATAP -0.18741927495551 1.50377641281313e-05 NA NA NA hsa-miR-126-3p IRS1 -0.119923656289432 0.848922969843872 -0.0224800910783998 0.964603432953669 miRNAWalker2_validate;miRTarBase;miRNATAP -0.183270061294187 0.00600495405511337 24312276;23981989;26893720 Down regulation of miR 126 is associated with colorectal cancer cells proliferation migration and invasion by targeting IRS 1 via the AKT and ERK1/2 signaling pathways; In this study we identified the potential effects of miR-126 on some important biological properties of CRC cells and clarified the regulation of insulin receptor substrate 1 IRS-1 and its possible signaling pathway by miR-126; The 3'-untranslated region 3'-UTR of IRS-1 regulated by miR-126 was analyzed by using a dual-luciferase reporter assay; We found that IRS-1 is the functional downstream target of miR-126 by directly targeting the 3'-UTR of IRS-1; Endogenous miR-126 and exogenous miR-126 mimic inhibited IRS-1 expression; Furthermore gain-of-function or loss-of-function studies showed that over-expression of miR-126 down-regulated IRS-1 suppressed AKT and ERK1/2 activation CRC cells proliferation migration invasion and caused cell cycle arrest but had no effect on cell apoptosis; Knockdown of miR-126 promoted these processes in HCT-116 cells and promoted AKT and ERK1/2 activation by up-regulating the expression of the IRS-1 protein; MiR-126 may play roles in regulation of the biological behavior of CRC cells at least in part by targeting IRS-1 via AKT and ERK1/2 signaling pathways;It has been shown that IRS1 SLC75A and TOM1 were the potential target genes of miR-126 in colon cancer;Molecular mechanism investigation established that insulin receptor substrate 1 IRS1 functioned as a direct miR-126 target and its expression was negatively regulated by miR-126 at a post-transcriptional level in the SKOV3 cells; Additionally the overexpression of IRS1 reversed the inhibitory effect of miR-126 overexpression on SKOV3 cell migration and invasion; In conclusion the current study demonstrated that miR-126 inhibited EC cell migration and invasion at least partially through the direct targeting of IRS1 suggesting that miR-126 may aid the treatment of EC metastasis ;;cell migration;metastasis colorectal cancer;colon cancer;endometrial cancer hsa-miR-148a-3p IRS1 -0.324144803192141 0.746264759480212 -0.0224800910783998 0.964603432953669 miRNAWalker2_validate;miRTarBase -0.157041973286888 0.00893965311584429 NA NA NA hsa-miR-200c-3p IRS1 -0.333638625701646 0.813830738880144 -0.0224800910783998 0.964603432953669 miRNATAP -0.207702508759692 6.57325119957687e-05 NA NA NA hsa-miR-203a-3p IRS1 -0.472290269049916 0.632432558722238 -0.0224800910783998 0.964603432953669 MirTarget -0.133712721730684 0.00033909814630137 NA NA NA hsa-miR-616-5p IRS1 -0.321509218120179 0.271446046739636 -0.0224800910783998 0.964603432953669 MirTarget -0.151224571094709 0.00373231190849226 NA NA NA hsa-miR-107 IRS2 -0.289737369453023 0.769655185893943 0.297506911350594 0.603092879996597 PITA;miRanda;miRNATAP -0.25288129039537 0.00183250034356889 NA NA NA hsa-miR-98-5p IRS2 -0.0484028619275874 0.910781316485549 0.297506911350594 0.603092879996597 miRNAWalker2_validate;MirTarget -0.147657600810698 0.00605619946566084 NA NA NA hsa-miR-107 ISLR -0.289737369453023 0.769655185893943 0.461095099214968 0.497624223366267 miRNATAP -0.267842032890862 0.00893137963477742 NA NA NA hsa-miR-128-3p ISLR -0.0364518492233463 0.95841670253784 0.461095099214968 0.497624223366267 MirTarget -0.271834545945407 0.0109304824722465 NA NA NA hsa-miR-15b-5p ISLR 0.251826642099145 0.790709218602499 0.461095099214968 0.497624223366267 MirTarget;miRNATAP -0.249973255742229 0.0184977270612957 NA NA NA hsa-miR-148a-3p ISM1 -0.324144803192141 0.746264759480212 0.769885409879741 0.103585462607808 miRNATAP -0.230186412842318 0.0178114778547806 NA NA NA hsa-miR-214-3p ISM2 0.0312810611346688 0.952640488671912 -0.447985764857535 0.366274369255956 mirMAP -0.183684773326737 0.0210175327539833 NA NA NA hsa-miR-106a-5p ITFG1 -0.820057689616516 0.0254490146664247 0.156685873742845 0.761829255600678 MirTarget -0.125178181431556 7.9620098298105e-08 NA NA NA hsa-miR-106b-5p ITFG1 -0.3941595235172 0.389635342155994 0.156685873742845 0.761829255600678 MirTarget -0.117019562315902 0.00139712623684618 NA NA NA hsa-miR-17-5p ITFG1 -0.643066792834501 0.320674049526638 0.156685873742845 0.761829255600678 MirTarget;TargetScan -0.11605539805101 7.71105903491334e-05 NA NA NA hsa-miR-20a-5p ITFG1 -0.857283498361138 0.070259604943771 0.156685873742845 0.761829255600678 MirTarget -0.101063977141658 1.87080456731785e-05 NA NA NA hsa-miR-140-3p ITFG2 -0.105651799466207 0.9077781740714 0.063314020954091 0.896957600465477 MirTarget -0.102812098769551 0.0251423608422636 NA NA NA hsa-miR-15b-5p ITGA10 0.251826642099145 0.790709218602499 -0.0268966871664938 0.934103534101151 MirTarget -0.23080291613485 0.0196697292205923 NA NA NA hsa-miR-106a-5p ITGB8 -0.820057689616516 0.0254490146664247 0.0364922496964377 0.960165477566282 MirTarget;miRNATAP -0.169678895937684 0.00114660300049988 NA NA NA hsa-miR-181b-5p ITGB8 -0.0483087651223055 0.952929800264921 0.0364922496964377 0.960165477566282 miRNATAP -0.165344936910092 0.027757869270029 NA NA NA hsa-miR-107 ITGBL1 -0.289737369453023 0.769655185893943 1.06516210037955 0.0749037459510402 miRanda -0.497462176737539 0.00481711960703225 NA NA NA hsa-miR-107 ITM2A -0.289737369453023 0.769655185893943 0.0833868250902436 0.82186549829893 miRanda -0.285094427221194 0.000335649954164568 NA NA NA hsa-miR-186-5p ITM2A -0.246324984406451 0.701310703524093 0.0833868250902436 0.82186549829893 mirMAP -0.216346938186346 0.0104632433908301 NA NA NA hsa-miR-26b-5p ITM2A 0.16143906971203 0.790777916193478 0.0833868250902436 0.82186549829893 miRNAWalker2_validate -0.300989415133334 0.000534702099748052 NA NA NA hsa-miR-296-3p ITM2A 0.305371903227786 0.470342914513253 0.0833868250902436 0.82186549829893 MirTarget;PITA;miRanda;miRNATAP -0.140954727767537 0.00393370902612976 NA NA NA hsa-miR-429 ITM2A -0.596617415946644 0.128967410286089 0.0833868250902436 0.82186549829893 miRanda -0.11401683200478 0.0279199693814819 NA NA NA hsa-miR-15b-5p ITPR1 0.251826642099145 0.790709218602499 -0.129629234763097 0.738254587356145 MirTarget;miRNATAP -0.136670849880866 0.0475770418655366 NA NA NA hsa-miR-15b-5p IVNS1ABP 0.251826642099145 0.790709218602499 -0.0568292701092341 0.92742211373667 MirTarget -0.104892194197954 0.01081923177017 NA NA NA hsa-miR-106a-5p JAM2 -0.820057689616516 0.0254490146664247 0.571497114031113 0.100029451445325 miRNATAP -0.143144795085258 0.00983277243741088 NA NA NA hsa-miR-335-3p JAM2 0.0738544228922926 0.89349398283313 0.571497114031113 0.100029451445325 mirMAP -0.138902444716137 0.0159712003841196 NA NA NA hsa-miR-429 JAM2 -0.596617415946644 0.128967410286089 0.571497114031113 0.100029451445325 miRNATAP -0.219272411897557 0.000187203785387889 NA NA NA hsa-miR-616-5p JAM2 -0.321509218120179 0.271446046739636 0.571497114031113 0.100029451445325 mirMAP -0.172701777086823 0.00602899082218971 NA NA NA hsa-miR-15b-5p JARID2 0.251826642099145 0.790709218602499 -0.188189262266655 0.679298581855395 MirTarget;miRNATAP -0.133974958189078 0.0204861110476628 NA NA NA hsa-miR-22-3p JARID2 0.0468440219945929 0.967778504781139 -0.188189262266655 0.679298581855395 miRNATAP -0.174613800929565 3.93215635377854e-05 NA NA NA hsa-miR-148a-3p JPH3 -0.324144803192141 0.746264759480212 -0.620590433652452 0.344974424522281 miRNATAP -0.314706607143168 0.0434690662966255 NA NA NA hsa-miR-141-3p KBTBD11 -0.36932301319088 0.428364456128406 -0.502427373815905 0.222365492034813 mirMAP -0.238149496977844 0.0123253187146849 NA NA NA hsa-miR-885-5p KBTBD11 -0.119561979753203 0.861296588445352 -0.502427373815905 0.222365492034813 mirMAP -0.130329100381237 0.00695345823777162 NA NA NA hsa-miR-27a-3p KCNA6 0.309634509674364 0.703724209648479 0.488516332017855 0.324924076717191 MirTarget -0.268828255659389 0.0374071362841579 NA NA NA hsa-miR-98-5p KCNA6 -0.0484028619275874 0.910781316485549 0.488516332017855 0.324924076717191 mirMAP -0.268773391419768 0.00593673180634528 NA NA NA hsa-miR-17-5p KCNB1 -0.643066792834501 0.320674049526638 0.42726555361718 0.433419294689488 TargetScan -0.281700760011144 0.0224702929587174 NA NA NA hsa-miR-15b-5p KCNC1 0.251826642099145 0.790709218602499 0.0449547611912151 0.929136954680909 mirMAP -0.305225473034932 0.0248350568218567 NA NA NA hsa-miR-22-3p KCNC1 0.0468440219945929 0.967778504781139 0.0449547611912151 0.929136954680909 miRNATAP -0.362789626503336 0.000294608788651507 NA NA NA hsa-miR-107 KCNIP1 -0.289737369453023 0.769655185893943 0.0418634328515107 0.945869777268282 MirTarget;miRanda -0.470191792991668 0.0106550954093395 NA NA NA hsa-miR-150-5p KCNIP1 -0.00683324482969283 0.994067057151257 0.0418634328515107 0.945869777268282 MirTarget;miRNATAP -0.386018138695552 8.25785151227497e-06 NA NA NA hsa-miR-15b-5p KCNIP1 0.251826642099145 0.790709218602499 0.0418634328515107 0.945869777268282 MirTarget -0.407013863741538 0.0329544013246179 NA NA NA hsa-miR-214-3p KCNIP3 0.0312810611346688 0.952640488671912 -0.395627468269231 0.366755156433478 mirMAP -0.134985231732185 0.00799339061290436 NA NA NA hsa-miR-107 KCNIP4 -0.289737369453023 0.769655185893943 0.0361117044945495 0.915681005481963 miRanda -0.231162979782349 0.0207151352107455 NA NA NA hsa-miR-214-3p KCNJ11 0.0312810611346688 0.952640488671912 -0.354625483231593 0.230626092648994 mirMAP -0.153423458267942 9.23081154928086e-05 NA NA NA hsa-miR-150-5p KCNJ12 -0.00683324482969283 0.994067057151257 0.0346871570737179 0.938318748638831 mirMAP -0.141205770109722 0.0130338450460305 NA NA NA hsa-let-7a-3p KCNJ16 0.0395190175369595 0.888702137550015 -0.154972193477868 0.820475219732571 mirMAP -0.345977637401179 0.0345259078594126 NA NA NA hsa-miR-146a-5p KCNJ16 -0.129284021174742 0.817914855859866 -0.154972193477868 0.820475219732571 MirTarget -0.23295477734325 0.0364498400768562 NA NA NA hsa-miR-27a-5p KCNJ16 -0.00797189811576748 0.985270279280688 -0.154972193477868 0.820475219732571 MirTarget -0.266593453266837 0.0381701136399265 NA NA NA hsa-miR-107 KCNK1 -0.289737369453023 0.769655185893943 0.174143902690535 0.685930560270308 miRanda -0.188160819642605 0.0109898520859398 NA NA NA hsa-miR-15b-5p KCNK3 0.251826642099145 0.790709218602499 0.0285178702321485 0.953451017519098 mirMAP -0.505098752069605 0.000424765513039642 NA NA NA hsa-miR-27a-3p KCNK3 0.309634509674364 0.703724209648479 0.0285178702321485 0.953451017519098 mirMAP -0.302783555963427 0.0126823729102048 NA NA NA hsa-miR-106b-5p KCNMA1 -0.3941595235172 0.389635342155994 0.290955206291165 0.582265153220965 miRNATAP -0.199556045678063 0.0239466292859786 NA NA NA hsa-miR-17-5p KCNMA1 -0.643066792834501 0.320674049526638 0.290955206291165 0.582265153220965 miRNATAP -0.159380477216971 0.0251493975761353 NA NA NA hsa-miR-362-5p KCNMA1 -0.35564884735017 0.452162806620853 0.290955206291165 0.582265153220965 PITA;miRNATAP -0.119629986075035 0.0312783756204077 NA NA NA hsa-miR-744-3p KCNMA1 0.111079149628683 0.794388290953005 0.290955206291165 0.582265153220965 miRNATAP -0.116206172322167 0.0457960672843498 NA NA NA hsa-miR-9-5p KCNMA1 0.029299723902132 0.964227616086639 0.290955206291165 0.582265153220965 mirMAP;miRNATAP -0.191961018716002 2.34201256540285e-06 NA NA NA hsa-miR-93-5p KCNMA1 -0.375078982324499 0.732311284477601 0.290955206291165 0.582265153220965 miRNATAP -0.195342935772268 0.0202732263847713 NA NA NA hsa-miR-940 KCNMA1 0.19340062942074 0.679749292292113 0.290955206291165 0.582265153220965 PITA;miRNATAP -0.131043023162801 0.0303046083602904 NA NA NA hsa-miR-195-3p KCNMB2 -0.156258661515859 0.711891893678154 0.208236732160485 0.651153545808377 MirTarget -0.234599021639623 0.0131718630788121 NA NA NA hsa-miR-323a-3p KCNMB2 0.515986769154502 0.275467412974017 0.208236732160485 0.651153545808377 MirTarget -0.186096508088516 0.00366139605592953 NA NA NA hsa-miR-381-3p KCNMB2 0.269633663970002 0.562625029053898 0.208236732160485 0.651153545808377 MirTarget -0.197848588857467 0.0201384647899008 NA NA NA hsa-miR-107 KCNN4 -0.289737369453023 0.769655185893943 0.346381357032025 0.48013118024966 MirTarget;miRanda;miRNATAP -0.279794464422368 0.0248428011346287 NA NA NA hsa-miR-107 KCNT2 -0.289737369453023 0.769655185893943 -0.030446953926676 0.942722530787762 miRanda -0.272433801065968 0.0315326043545785 NA NA NA hsa-miR-192-5p KCTD12 -0.00281508349767456 0.99638352116085 -0.148448503782689 0.834681371239376 miRNAWalker2_validate -0.137754119924562 0.00369440240911736 NA NA NA hsa-miR-539-5p KCTD12 0.551428040760553 0.139269787059339 -0.148448503782689 0.834681371239376 mirMAP -0.120425264123836 0.00381880098511477 NA NA NA hsa-miR-616-5p KCTD12 -0.321509218120179 0.271446046739636 -0.148448503782689 0.834681371239376 MirTarget;miRNATAP -0.102503548064657 0.0496969558145282 NA NA NA hsa-miR-877-3p KCTD12 -0.228887480748248 0.565006251347097 -0.148448503782689 0.834681371239376 mirMAP -0.161987823419249 0.000243839872845054 NA NA NA hsa-miR-9-5p KCTD12 0.029299723902132 0.964227616086639 -0.148448503782689 0.834681371239376 MirTarget;miRNATAP -0.246799914690822 6.11930350734906e-15 NA NA NA hsa-miR-940 KCTD12 0.19340062942074 0.679749292292113 -0.148448503782689 0.834681371239376 MirTarget -0.19729661728609 4.14340177115072e-05 NA NA NA hsa-miR-150-5p KDM5B -0.00683324482969283 0.994067057151257 0.0477380054298591 0.937073866443259 MirTarget -0.129795842646146 8.54129077377513e-08 NA NA NA hsa-miR-150-5p KIAA0895L -0.00683324482969283 0.994067057151257 -0.259582911935119 0.480275217430713 MirTarget -0.105100963244966 0.000150397418688473 NA NA NA hsa-miR-127-3p KIAA0907 0.231539840651733 0.822108193638849 -0.336399778058736 0.531252699795224 miRanda -0.106796800687829 6.36918029198336e-06 NA NA NA hsa-miR-326 KIAA0907 0.307641210889423 0.653580115931293 -0.336399778058736 0.531252699795224 miRanda -0.123560831647759 2.04537187287361e-07 NA NA NA hsa-miR-27a-3p KIAA1210 0.309634509674364 0.703724209648479 0.639834659401867 0.252097233883892 MirTarget -0.35544282181838 0.0148411461132273 NA NA NA hsa-miR-22-3p KIAA1257 0.0468440219945929 0.967778504781139 -0.176569610521038 0.605655150830703 mirMAP -0.285836979569127 0.00021029791594567 NA NA NA hsa-miR-660-5p KIAA1324L -0.561687438133488 0.138270972367544 0.633500734696163 0.178357474167354 MirTarget -0.193347436411658 0.020721058971908 NA NA NA hsa-miR-148a-3p KIAA1644 -0.324144803192141 0.746264759480212 0.706029111299509 0.143146152697486 mirMAP -0.473877308901702 2.59800115805737e-05 NA NA NA hsa-miR-27a-3p KIAA2022 0.309634509674364 0.703724209648479 -0.513184227302334 0.28975747914921 miRNATAP -0.293424869398033 0.0187310647122244 NA NA NA hsa-miR-30a-5p KIF11 -0.163405499812159 0.87950357765238 0.0350132405426953 0.942878375019002 miRNAWalker2_validate;MirTarget -0.101944475786593 0.0153619486081506 NA NA NA hsa-miR-30d-5p KIF11 -0.127037899273548 0.917197761243139 0.0350132405426953 0.942878375019002 MirTarget -0.13288429147717 0.0153894048325956 NA NA NA hsa-miR-664a-3p KIF11 -0.139841943049965 0.800834383581795 0.0350132405426953 0.942878375019002 MirTarget -0.299141657494796 4.16285562475462e-09 NA NA NA hsa-miR-103a-3p KIF13B -0.360357769638318 0.770748924684999 -0.119827616199206 0.791700468200055 mirMAP -0.109608269005707 0.022852176093558 NA NA NA hsa-miR-107 KIF13B -0.289737369453023 0.769655185893943 -0.119827616199206 0.791700468200055 mirMAP -0.121488659001467 0.0295224662599821 NA NA NA hsa-miR-130b-5p KIF13B -0.318833907124358 0.508178803208229 -0.119827616199206 0.791700468200055 mirMAP -0.209499386665006 3.24231614938289e-05 NA NA NA hsa-miR-146b-5p KIF13B 0.0340352805627226 0.964565988329585 -0.119827616199206 0.791700468200055 miRanda -0.111296977990878 0.00236439103645311 NA NA NA hsa-let-7b-3p KIF14 0.314328399485033 0.684245834514538 -0.200176531715372 0.54447288396825 MirTarget -0.2395548124768 0.000117967779521132 NA NA NA hsa-miR-15a-5p KIF1A -0.288312177100971 0.506274963146038 -1.13617336538192 0.15532389706797 miRNAWalker2_validate -0.367577551725312 0.0108061177350018 NA NA NA hsa-miR-214-5p KIF1A 0.413556552206067 0.383857606213638 -1.13617336538192 0.15532389706797 mirMAP -0.334349045546945 0.00931467302140817 NA NA NA hsa-miR-29a-3p KIF1A 0.203872357562561 0.859946061784007 -1.13617336538192 0.15532389706797 mirMAP -0.687152748774208 4.14298412593722e-05 NA NA NA hsa-miR-29b-3p KIF1A -0.249746665931503 0.558208927436524 -1.13617336538192 0.15532389706797 mirMAP -0.439961986499493 0.0002155717431057 NA NA NA hsa-miR-29c-3p KIF1A 0.042533372292219 0.941334605544826 -1.13617336538192 0.15532389706797 mirMAP -0.391320490769644 0.00444091935497303 NA NA NA hsa-miR-15b-5p KIF1C 0.251826642099145 0.790709218602499 -0.19380663203288 0.754275365507274 miRNATAP -0.114585733398954 0.0135303648721741 NA NA NA hsa-miR-140-3p KIF21A -0.105651799466207 0.9077781740714 -0.0146418276057512 0.971849807866891 miRNAWalker2_validate -0.141414038994353 0.00833531481221926 NA NA NA hsa-miR-98-5p KIF21B -0.0484028619275874 0.910781316485549 -0.687581204556475 0.0316752721293158 mirMAP -0.132662291613362 0.00571596491000681 NA NA NA hsa-miR-125a-5p KIF23 -0.00666761469427968 0.994891296705929 -0.157138759091675 0.729279888359708 miRanda -0.50113580982989 1.41323150450409e-09 NA NA NA hsa-miR-320c KIF23 0.092255964601645 0.785539881268253 -0.157138759091675 0.729279888359708 miRanda -0.157819300700775 0.000711450110571287 NA NA NA hsa-miR-101-3p KIF2C -0.0149915187591869 0.981999725022451 -0.257238123825293 0.610228032131957 miRNAWalker2_validate -0.185639700861467 0.00193915313761607 NA NA NA hsa-miR-15a-5p KIF5C -0.288312177100971 0.506274963146038 -0.214176481224448 0.65739959627831 MirTarget;miRNATAP -0.170238188781655 0.0139483792257332 NA NA NA hsa-miR-21-3p KIF5C 0.129101420041684 0.877913267462969 -0.214176481224448 0.65739959627831 mirMAP -0.151090899370691 0.0242409526386983 NA NA NA hsa-miR-582-3p KIF5C -0.412732829130276 0.327362626701922 -0.214176481224448 0.65739959627831 PITA -0.113393027578979 0.0293312805011005 NA NA NA hsa-miR-22-3p KIF6 0.0468440219945929 0.967778504781139 -0.18634088212664 0.56919306846748 mirMAP -0.199720537693854 0.00571370946047905 NA NA NA hsa-let-7b-5p KIFC1 0.396604576702067 0.783406687058469 -0.37189318227566 0.448636926114888 miRNAWalker2_validate -0.205726122714877 5.63253019196118e-05 NA NA NA hsa-miR-15b-5p KIRREL 0.251826642099145 0.790709218602499 -0.464996657308794 0.357002291272135 mirMAP -0.206298793244936 0.00236587116880985 NA NA NA hsa-miR-22-3p KIRREL3 0.0468440219945929 0.967778504781139 -0.26770541854455 0.650274388437893 MirTarget;miRNATAP -0.72484556173782 2.18005714700607e-08 NA NA NA hsa-miR-128-3p KIT -0.0364518492233463 0.95841670253784 -0.249221513956445 0.534286727599588 MirTarget -0.363356596326259 0.00307640966311547 NA NA NA hsa-miR-221-3p KIT -0.261179092929062 0.744019631321393 -0.249221513956445 0.534286727599588 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.283844538803818 0.00215385132092908 NA NA NA hsa-miR-222-3p KIT -0.233673471709747 0.726651775432807 -0.249221513956445 0.534286727599588 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.26432386719203 0.00401569380370608 NA NA NA hsa-miR-15b-5p KLC4 0.251826642099145 0.790709218602499 -0.110966849190025 0.803478523433492 miRNATAP -0.147389783263023 0.00146565389708043 NA NA NA hsa-miR-660-5p KLF12 -0.561687438133488 0.138270972367544 -0.107461049696606 0.79612046968107 mirMAP -0.137279748476102 0.000431308344835292 NA NA NA hsa-miR-25-3p KLF2 0.0681841609869576 0.955267320175687 0.313901881983388 0.475595282889387 miRNATAP -0.361967299780419 3.89819028561874e-05 NA NA NA hsa-miR-92a-3p KLF2 0.0155161307487504 0.991444817308063 0.313901881983388 0.475595282889387 miRNAWalker2_validate;miRTarBase;miRNATAP -0.262318084090843 0.0019356914391328 NA NA NA hsa-miR-92b-3p KLF2 0.454620627632174 0.646193882241421 0.313901881983388 0.475595282889387 miRNATAP -0.199167591766429 0.000290286549053355 NA NA NA hsa-miR-10b-5p KLF4 -0.866656492462537 0.502462749031016 -0.149037121312608 0.733988656060029 miRNAWalker2_validate;miRTarBase;miRNATAP -0.128749088846622 0.00436689098541305 26191201;25428807;27764757;24216130;20075075;24573354;25063061 Augmented miR 10b expression associated with depressed expression of its target gene KLF4 involved in gastric carcinoma; In this study we aimed to assess whether Krüppel-like factor 4 KLF4 is a target gene of miR-10b in gastric cancer GC; Targeting of KLF4 by miR-10b was confirmed by dual-luciferase reporter assays; The expression levels of miR-10b and KLF4 mRNA in 5 different gastric cancer cell lines and 65 pairs of gastric cancer tissues were detected by Real-time PCR; KLF4 is a direct target gene of miR-10b in GC and its expression is reduced by miR-10b at both mRNA and protein levels; In addition the expression level of miR-10b was tendentiously upregulated in GC tissues while the expression levels of KLF4 mRNA and protein were decreased in gastric cancer tissues compared with normal adjacent tissue; There was a dramatically inverse correlation between the expression levels of miR-10b and KLF4 mRNA in GC r=-0.339 P=0.006; These findings indicate that miR-10b was upregulated in GC and may have a key role in GC pathogenesis and development through the downregulation of its target gene KLF4;Moreover upon uptake miR-10b can suppress the protein level of its target genes such as HOXD10 and KLF4 indicating its functional significance;miR 10b promotes invasion by targeting KLF4 in osteosarcoma cells; The relationship between miR-10b and KLF4 was evaluated using dual-luciferase assay correlation analysis; miR-10b is overexpressed in osteosarcoma and KLF4 is the direct target gene of miR-10b; Furthermore miR-10b promotes osteosarcoma cells progression by downregulating KLF4 expression;Krüppel-like factor 4 KLF4 may be indirectly targeted by miR-10b during the proliferation increasing of A549 cells;MicroRNA 10b promotes migration and invasion through KLF4 in human esophageal cancer cell lines; Additionally we identified KLF4 a known tumor suppressor gene that has been reported to suppress esophageal cancer cell migration and invasion as a direct target of miR-10b; Furthermore overexpression of miR-10b in KYSE140 and KYSE450 cells led to a reduction of endogenous KLF4 protein whereas silencing of miR-10b in EC9706 cells caused up-regulation of KLF4 protein; Coexpression of miR-10b and KLF4 in KYSE140 cells and coexpression of small interfering RNA for KLF4 mRNA and miR-10b-AS in EC9706 cells partially abrogated the effect of miR-10b on cell migration and invasion;MicroRNA 10b promotes migration and invasion through KLF4 and HOXD10 in human bladder cancer; Luciferase assays were also performed to validate KLF4 and HOXD10 as miR-10b targets; Moreover KLF4 and HOXD10 were identified as direct targets of miR-10b in BC cells;MicroRNA-10b may promote proliferation and invasion of 95-C cells by down regulating the expression of KLF4 protein ;;progression;;cell migration;; gastric cancer;breast cancer;sarcoma;lung squamous cell cancer;esophageal cancer;bladder cancer;lung cancer hsa-miR-200c-3p KLF4 -0.333638625701646 0.813830738880144 -0.149037121312608 0.733988656060029 MirTarget;miRNATAP -0.116020561523148 0.0448192994121555 NA NA NA hsa-miR-27a-3p KLHDC3 0.309634509674364 0.703724209648479 0.0387392356539085 0.951213672188197 miRNATAP -0.161009505380736 4.51534545013357e-05 NA NA NA hsa-miR-150-5p KLHDC7A -0.00683324482969283 0.994067057151257 -0.994594569515364 0.150801770627861 MirTarget -0.34699560802752 0.000397295578748116 NA NA NA hsa-miR-15b-5p KLHDC8B 0.251826642099145 0.790709218602499 0.0454131157340809 0.918204980978242 MirTarget -0.113061740181551 0.0141064369951752 NA NA NA hsa-let-7a-5p KLHL23 0.0514604984725615 0.971564723582327 -0.423990290359443 0.198187896488329 MirTarget;TargetScan;miRNATAP -0.212838924888159 0.00175513023798391 NA NA NA hsa-let-7b-5p KLHL23 0.396604576702067 0.783406687058469 -0.423990290359443 0.198187896488329 MirTarget;miRNATAP -0.285476930807857 5.68692765082318e-08 NA NA NA hsa-let-7d-5p KLHL23 0.0119393569456978 0.988390093874148 -0.423990290359443 0.198187896488329 MirTarget;miRNATAP -0.227038977004406 0.000234587018312412 NA NA NA hsa-let-7g-5p KLHL23 -0.320647530232065 0.660364346555039 -0.423990290359443 0.198187896488329 MirTarget;miRNATAP -0.1356692661981 0.0190801669699009 NA NA NA hsa-let-7i-5p KLHL23 -0.0940710536612883 0.902310710205355 -0.423990290359443 0.198187896488329 MirTarget;miRNATAP -0.218538252536208 0.000246243908483367 NA NA NA hsa-miR-199a-5p KLHL23 0.248253058498817 0.7461266806999 -0.423990290359443 0.198187896488329 miRNATAP -0.158365925956088 5.00924930680623e-05 NA NA NA hsa-miR-199b-5p KLHL23 0.415198317247236 0.324258779965011 -0.423990290359443 0.198187896488329 miRNATAP -0.130373615457533 0.000298091599906771 NA NA NA hsa-miR-224-5p KLHL23 -0.143123534787342 0.827443367193551 -0.423990290359443 0.198187896488329 MirTarget -0.118786551751696 1.18057689434188e-05 NA NA NA hsa-miR-24-3p KLHL23 0.0408517902063537 0.966828370841971 -0.423990290359443 0.198187896488329 miRNAWalker2_validate -0.163643951039534 0.0140800879400339 NA NA NA hsa-miR-29b-1-5p KLHL24 -0.188524660858621 0.603438322810761 -0.0402101464687403 0.945875874192269 MirTarget -0.105850999295139 0.00106952632588861 NA NA NA hsa-miR-139-5p KLHL32 -0.0625698939687087 0.914810329989088 0.525800535583096 0.14623328382037 miRanda -0.189841398607915 0.0300716357516406 NA NA NA hsa-miR-129-5p KLK7 0.417083435812871 0.454236109516901 0.448845440926167 0.591311676189695 miRanda -0.152705097030201 0.0175817269512334 NA NA NA hsa-miR-377-5p KLK7 0.430163909966986 0.349805669730749 0.448845440926167 0.591311676189695 MirTarget -0.191171291997813 0.00550144388274752 NA NA NA hsa-miR-766-3p KLK7 0.103832486444169 0.839257506039953 0.448845440926167 0.591311676189695 MirTarget -0.192232996251884 0.0404235212991426 NA NA NA hsa-miR-107 KNDC1 -0.289737369453023 0.769655185893943 0.176943515244534 0.758285234329918 miRanda -0.56883052343834 0.000930541047870098 NA NA NA hsa-miR-100-5p KPNA2 0.0542447471759004 0.961097766133859 0.00244023847320474 0.997044072584389 miRNAWalker2_validate -0.159222520362083 2.81614547292697e-05 NA NA NA hsa-miR-26a-5p KPNA2 0.0483232931294246 0.955218190818435 0.00244023847320474 0.997044072584389 MirTarget -0.286565480942984 1.13848208169017e-05 NA NA NA hsa-let-7a-3p KRAS 0.0395190175369595 0.888702137550015 0.0135426868156925 0.98016869715642 mirMAP;miRNATAP -0.108806063801151 0.0411896887350361 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-let-7a-5p KRAS 0.0514604984725615 0.971564723582327 0.0135426868156925 0.98016869715642 miRNAWalker2_validate;miRTarBase -0.173439384002891 0.0109496483548052 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-let-7b-3p KRAS 0.314328399485033 0.684245834514538 0.0135426868156925 0.98016869715642 mirMAP;miRNATAP -0.219799838736189 0.000146584771964146 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;26581910;22584434;26516699;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS;Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA;Interestingly the differential expression of miRNA in mice also corroborated with the miRNA expression in human PC cell lines and tissue samples; ectopic expression of Let-7b in CD18/HPAF and Capan1 cells resulted in the downregulation of KRAS and MSST1 expression;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;;;; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;pancreatic cancer;lung squamous cell cancer hsa-let-7g-5p KRAS -0.320647530232065 0.660364346555039 0.0135426868156925 0.98016869715642 miRNAWalker2_validate;miRTarBase -0.159945258726427 0.00559317015539551 NA NA NA hsa-miR-126-3p KRAS -0.119923656289432 0.848922969843872 0.0135426868156925 0.98016869715642 miRNAWalker2_validate;miRTarBase -0.17454202935918 0.0028968255488591 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK pancreatic cancer hsa-miR-155-5p KRAS -0.320577372003167 0.673183036961734 0.0135426868156925 0.98016869715642 miRNAWalker2_validate;miRNATAP -0.118969766098365 0.00601695924074059 NA NA NA hsa-miR-193b-3p KRAS 0.228475522385047 0.747332810847705 0.0135426868156925 0.98016869715642 miRNAWalker2_validate;MirTarget;miRNATAP -0.11171765243837 0.0374285148256067 25905463 Deregulation of the MiR 193b KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer; Mechanistically KRAS was verified as a direct effector of miR-193b through which the AKT and ERK pathways were modulated and cell growth of PDAC cells was suppressed; Taken together our findings indicate that miR-193b-mediated deregulation of the KRAS axis is involved in pancreatic carcinogenesis and suggest that miR-193b could be a potentially effective target for PDAC therapy tumorigenesis pancreatic cancer hsa-miR-195-3p KRAS -0.156258661515859 0.711891893678154 0.0135426868156925 0.98016869715642 mirMAP -0.156343295672095 0.000718270091055249 NA NA NA hsa-miR-27a-3p KRAS 0.309634509674364 0.703724209648479 0.0135426868156925 0.98016869715642 miRNATAP -0.15119388054973 0.00919299839947551 24154848;25436011 microRNA 27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS; Furthermore we demonstrated that miR-27a binds to the 3'-untranslated region UTR of KRAS and inhibits the expression of the KRAS protein; miR-27a levels were inversely correlated with levels of KRAS mRNA and protein in ESCC specimens; Our findings suggest for the first time that miR-27a suppresses tumorigenesis of ESCC by targeting KRAS;MicroRNA 27a directly targets KRAS to inhibit cell proliferation in esophageal squamous cell carcinoma; However the expression level of the target gene KRAS was upregulated and ESCC cell proliferation was significantly inhibited following miR-27a mimic or small interfering K-ras transfection; In conclusion the present study demonstrated that the expression level of miR-27a was low in ESCC and that miR-27a directly targets the KRAS gene resulting in inhibited cell proliferation in esophageal cancer tumorigenesis; esophageal cancer;esophageal cancer hsa-miR-27b-3p KRAS 0.306246927737414 0.735781270461428 0.0135426868156925 0.98016869715642 miRNATAP -0.21492738960827 0.000511954014406835 NA NA NA hsa-miR-30a-3p KRAS 0.11336767305191 0.920646436414994 0.0135426868156925 0.98016869715642 MirTarget;miRNATAP -0.109465586820024 0.0330300631349621 NA NA NA hsa-miR-30b-5p KRAS -0.298771188216537 0.582864939841563 0.0135426868156925 0.98016869715642 mirMAP;miRNATAP -0.186710571227803 0.000362624179179931 NA NA NA hsa-miR-30d-5p KRAS -0.127037899273548 0.917197761243139 0.0135426868156925 0.98016869715642 mirMAP;miRNATAP -0.20030291594729 0.00168670251584685 NA NA NA hsa-miR-30e-3p KRAS 0.202355073367528 0.857417040078429 0.0135426868156925 0.98016869715642 MirTarget -0.14465187816916 0.0431921858843677 NA NA NA hsa-miR-30e-5p KRAS -0.00273037859886571 0.997115479601006 0.0135426868156925 0.98016869715642 mirMAP;miRNATAP -0.148477965079215 0.020309736735389 NA NA NA hsa-miR-139-5p KSR2 -0.0625698939687087 0.914810329989088 0.014552829135464 0.969087101509327 mirMAP -0.152695827615477 0.0479008270184896 NA NA NA hsa-miR-150-5p KSR2 -0.00683324482969283 0.994067057151257 0.014552829135464 0.969087101509327 mirMAP -0.129187390943998 0.003926928862325 NA NA NA hsa-miR-214-3p KY 0.0312810611346688 0.952640488671912 0.244492131660401 0.625929595987601 MirTarget -0.15847153452531 0.0487967178001024 NA NA NA hsa-miR-140-3p L2HGDH -0.105651799466207 0.9077781740714 -0.019312853149092 0.960282106984546 MirTarget -0.13974811900873 0.000740678187943566 NA NA NA hsa-miR-127-3p L3MBTL4 0.231539840651733 0.822108193638849 0.157146106434107 0.700533498651459 miRanda -0.157980757591556 0.0196705496421523 NA NA NA hsa-miR-30c-5p LACTB2 -0.183013966936985 0.833177718550926 0.255891000644191 0.605898247904662 miRNAWalker2_validate -0.142207787079196 0.0150068463285283 NA NA NA hsa-miR-320a LACTB2 0.142884703798297 0.888511174254355 0.255891000644191 0.605898247904662 miRanda -0.113134079641422 0.0381174932394643 NA NA NA hsa-miR-320b LACTB2 0.298760649675195 0.700446828731538 0.255891000644191 0.605898247904662 miRanda -0.102945153751836 0.018939812775352 NA NA NA hsa-miR-320c LACTB2 0.092255964601645 0.785539881268253 0.255891000644191 0.605898247904662 miRanda -0.169491253593844 0.000142431477903785 NA NA NA hsa-miR-320d LACTB2 0.353471568894745 0.357430999251147 0.255891000644191 0.605898247904662 miRanda -0.106887984880835 0.00226141293338415 NA NA NA hsa-miR-146b-5p LAMA2 0.0340352805627226 0.964565988329585 -0.454333844525348 0.309346665530004 miRanda -0.212591316187302 0.00302889581241217 NA NA NA hsa-miR-16-5p LAMB1 -0.199225750365017 0.742834324195084 0.186362894751858 0.736373319742865 miRNAWalker2_validate -0.165094278519143 0.0072834038307109 NA NA NA hsa-miR-339-5p LAMB1 -0.121565674268033 0.81427862647099 0.186362894751858 0.736373319742865 miRanda -0.126781197723971 0.0434136248401277 NA NA NA hsa-miR-107 LAPTM4A -0.289737369453023 0.769655185893943 0.305574789459078 0.688979545697046 PITA;miRanda;miRNATAP -0.136315081074781 0.000219626951219304 NA NA NA hsa-miR-15b-5p LATS1 0.251826642099145 0.790709218602499 -0.160115311260593 0.655519528966827 MirTarget;miRNATAP -0.121534685682813 0.00524690163098967 NA NA NA hsa-miR-107 LATS2 -0.289737369453023 0.769655185893943 0.121471542984644 0.778399929406237 PITA;miRanda;miRNATAP -0.103859864107493 0.0374228856943613 NA NA NA hsa-miR-27a-3p LBR 0.309634509674364 0.703724209648479 -0.259616935759679 0.587874017830765 miRNAWalker2_validate;MirTarget -0.152876515746015 0.000424379462795386 NA NA NA hsa-miR-98-5p LBR -0.0484028619275874 0.910781316485549 -0.259616935759679 0.587874017830765 MirTarget -0.135455952064989 3.56638653691643e-05 NA NA NA hsa-miR-26b-5p LDB2 0.16143906971203 0.790777916193478 0.213539991582082 0.521525050043958 miRNAWalker2_validate -0.15540281197717 0.0149754826692708 NA NA NA hsa-miR-197-3p LDHB 0.0240027695773914 0.981971058073739 0.035100553022934 0.960891001486546 miRNAWalker2_validate -0.156393248539817 0.0167022476720956 NA NA NA hsa-miR-221-3p LDHB -0.261179092929062 0.744019631321393 0.035100553022934 0.960891001486546 miRNAWalker2_validate -0.24881689500269 2.1334844314979e-07 NA NA NA hsa-miR-107 LDOC1L -0.289737369453023 0.769655185893943 0.0732429660355871 0.884216732301365 mirMAP -0.14600726677637 0.000293852477919896 NA NA NA hsa-miR-22-3p LEMD3 0.0468440219945929 0.967778504781139 0.222015168643809 0.612892589332979 miRNAWalker2_validate -0.105393272709764 1.3457383311654e-05 NA NA NA hsa-miR-27a-3p LENG1 0.309634509674364 0.703724209648479 0.037327368713973 0.899758730371754 miRNAWalker2_validate -0.115824843555249 0.00169847528049327 NA NA NA hsa-miR-197-3p LENG8 0.0240027695773914 0.981971058073739 -0.485021398564162 0.477316074769018 mirMAP -0.203792768793761 0.00307543837918475 NA NA NA hsa-miR-107 LEPR -0.289737369453023 0.769655185893943 0.309525993793621 0.426130331480391 miRanda -0.171137668812534 0.0253252419442746 NA NA NA hsa-miR-107 LEPROT -0.289737369453023 0.769655185893943 0.20649264862217 0.678697769568371 miRanda -0.110894562512417 0.0175410376200465 NA NA NA hsa-miR-128-3p LGALS3 -0.0364518492233463 0.95841670253784 0.0599871452596457 0.931418711140413 MirTarget -0.293292196138881 0.000117192101153153 NA NA NA hsa-let-7b-3p LGR4 0.314328399485033 0.684245834514538 0.340277037078073 0.592680452099709 MirTarget;miRNATAP -0.187216765340611 0.00484292596702152 NA NA NA hsa-let-7b-5p LGR4 0.396604576702067 0.783406687058469 0.340277037078073 0.592680452099709 MirTarget;miRNATAP -0.16799283026419 0.00598798990466193 NA NA NA hsa-miR-328-3p LGR4 0.326635455247326 0.676255782778498 0.340277037078073 0.592680452099709 MirTarget -0.131148116090766 0.0467578556572463 NA NA NA hsa-miR-150-5p LGSN -0.00683324482969283 0.994067057151257 0.949589630372217 0.240689387780884 mirMAP -0.50091778029195 8.14760855681538e-06 NA NA NA hsa-miR-197-3p LGSN 0.0240027695773914 0.981971058073739 0.949589630372217 0.240689387780884 MirTarget -0.585882794017705 0.0197414764286201 NA NA NA hsa-miR-214-3p LGSN 0.0312810611346688 0.952640488671912 0.949589630372217 0.240689387780884 MirTarget -0.466559234842506 0.000264367876171055 NA NA NA hsa-miR-107 LHFP -0.289737369453023 0.769655185893943 0.308864185492454 0.44929087901791 miRanda -0.204426166543221 0.00348683189629679 NA NA NA hsa-miR-129-5p LHFP 0.417083435812871 0.454236109516901 0.308864185492454 0.44929087901791 miRanda -0.113012955907908 0.00172284065072081 NA NA NA hsa-miR-141-3p LHFP -0.36932301319088 0.428364456128406 0.308864185492454 0.44929087901791 MirTarget -0.298982254399275 6.21731833386682e-08 NA NA NA hsa-miR-192-5p LHFP -0.00281508349767456 0.99638352116085 0.308864185492454 0.44929087901791 miRNAWalker2_validate -0.210320490452974 1.33391715858199e-06 NA NA NA hsa-miR-200a-3p LHFP -0.801422367541981 0.147987649395985 0.308864185492454 0.44929087901791 MirTarget -0.160443652129792 0.000281403321148149 NA NA NA hsa-miR-200b-3p LHFP -0.532909690027328 0.555970111970307 0.308864185492454 0.44929087901791 MirTarget;TargetScan -0.158284357631278 0.000525454621348711 NA NA NA hsa-miR-200c-3p LHFP -0.333638625701646 0.813830738880144 0.308864185492454 0.44929087901791 MirTarget;miRNATAP -0.249284699549063 1.78087348745344e-07 NA NA NA hsa-miR-9-5p LHFP 0.029299723902132 0.964227616086639 0.308864185492454 0.44929087901791 MirTarget;miRNATAP -0.100869428956699 0.000999340757347125 NA NA NA hsa-miR-139-5p LIAS -0.0625698939687087 0.914810329989088 0.185080367480859 0.543929506859105 miRanda -0.101662522930173 0.00912513083030352 NA NA NA hsa-miR-27a-3p LIFR 0.309634509674364 0.703724209648479 -0.15703128806339 0.75118949901895 miRNAWalker2_validate;MirTarget;miRNATAP -0.108578408120616 0.0498445559654987 NA NA NA hsa-miR-139-5p LIG3 -0.0625698939687087 0.914810329989088 -0.137909619388092 0.755487948338071 miRanda -0.111059978218129 0.00129492511966437 NA NA NA hsa-miR-22-3p LIG3 0.0468440219945929 0.967778504781139 -0.137909619388092 0.755487948338071 MirTarget -0.121992596997723 0.000162584482523215 NA NA NA hsa-miR-98-5p LIN28B -0.0484028619275874 0.910781316485549 -0.521391861717817 0.579651265320971 MirTarget -0.843434153375698 1.79709121848633e-06 NA NA NA hsa-miR-1301-3p LIPA -0.108695123599309 0.851745507068853 0.240503088113745 0.68324411093246 MirTarget -0.130322441693875 0.00267929944396111 NA NA NA hsa-miR-130a-3p LIPA -0.0153771286384572 0.977389403395331 0.240503088113745 0.68324411093246 MirTarget -0.150436515282708 0.000419190064744774 NA NA NA hsa-miR-27a-3p LIPT2 0.309634509674364 0.703724209648479 -0.22404916138226 0.426973642842975 MirTarget -0.154147709314646 0.00151150434808498 NA NA NA hsa-miR-17-5p LITAF -0.643066792834501 0.320674049526638 0.26159316047287 0.688685230363501 TargetScan -0.178706630561379 6.59306539554355e-05 NA NA NA hsa-miR-182-5p LITAF -0.262297863136789 0.8110070165759 0.26159316047287 0.688685230363501 MirTarget -0.105452692932159 0.00127770878890519 NA NA NA hsa-miR-148a-3p LIX1 -0.324144803192141 0.746264759480212 1.38152908666231 0.0646060302954672 MirTarget -0.48211593820723 0.00394351069773521 NA NA NA hsa-miR-101-3p LMNB1 -0.0149915187591869 0.981999725022451 -0.226012807190836 0.675482860805619 miRNAWalker2_validate;MirTarget;miRNATAP -0.15580509829961 0.00172283645753778 NA NA NA hsa-miR-125a-5p LMNB1 -0.00666761469427968 0.994891296705929 -0.226012807190836 0.675482860805619 miRanda -0.28384418216071 0.000315085455343372 NA NA NA hsa-miR-107 LMOD1 -0.289737369453023 0.769655185893943 0.660625205138824 0.112694741093249 miRanda -0.309563411891037 0.000494511464011501 NA NA NA hsa-miR-182-5p LMOD1 -0.262297863136789 0.8110070165759 0.660625205138824 0.112694741093249 miRNATAP -0.163954253171627 0.000816954423928562 NA NA NA hsa-miR-324-5p LMOD1 -0.358991607952497 0.499732551112182 0.660625205138824 0.112694741093249 PITA;miRanda -0.184987706582683 0.0190155670872257 NA NA NA hsa-miR-429 LMOD1 -0.596617415946644 0.128967410286089 0.660625205138824 0.112694741093249 miRNATAP -0.17627976469645 0.00225348380012414 NA NA NA hsa-miR-148a-3p LMX1B -0.324144803192141 0.746264759480212 -0.439282352711533 0.585599796955181 mirMAP -0.584363009929561 0.00189162997934254 NA NA NA hsa-miR-140-3p LONRF2 -0.105651799466207 0.9077781740714 0.17518072549086 0.758512937812653 mirMAP -0.236821550935239 0.0209528148400399 NA NA NA hsa-miR-27a-3p LPCAT1 0.309634509674364 0.703724209648479 -0.167536679372462 0.769159876369179 MirTarget -0.109952095640746 0.0166560438025069 NA NA NA hsa-miR-148a-3p LRFN1 -0.324144803192141 0.746264759480212 -0.0487923247334439 0.910270617742493 miRNATAP -0.143122385118137 0.0450088103037153 NA NA NA hsa-miR-15b-5p LRIG2 0.251826642099145 0.790709218602499 -0.252703166424234 0.46496130499088 MirTarget -0.134076011309992 0.00236004613662151 NA NA NA hsa-miR-107 LRP1 -0.289737369453023 0.769655185893943 0.145529955861141 0.84586158427387 PITA;miRNATAP -0.154767250159791 0.0276003095042737 NA NA NA hsa-miR-330-3p LRP2BP -0.1562229971038 0.692313620862782 0.109681458005981 0.685809868315097 MirTarget;PITA -0.225288167071411 7.3841433031121e-05 NA NA NA hsa-miR-340-3p LRP2BP -0.20764117397971 0.421529130586965 0.109681458005981 0.685809868315097 MirTarget -0.126140059356759 0.0388526191836189 NA NA NA hsa-miR-629-5p LRP2BP -0.466366787435144 0.39007918961798 0.109681458005981 0.685809868315097 mirMAP -0.225068690486661 0.000236025913805807 NA NA NA hsa-miR-15b-5p LRP6 0.251826642099145 0.790709218602499 -0.211448656253908 0.688300324114048 miRNATAP -0.147721783700826 0.0115172995153562 NA NA NA hsa-miR-221-3p LRP6 -0.261179092929062 0.744019631321393 -0.211448656253908 0.688300324114048 miRNAWalker2_validate -0.11974094819176 0.00696878773980775 NA NA NA hsa-miR-140-3p LRPAP1 -0.105651799466207 0.9077781740714 0.194198051930249 0.754949166141088 mirMAP -0.1627835593999 0.000119519422667773 NA NA NA hsa-miR-107 LRRC17 -0.289737369453023 0.769655185893943 0.932744754460012 0.0158534005392589 miRanda -0.254924783641566 0.0123886847511688 NA NA NA hsa-miR-98-5p LRRC17 -0.0484028619275874 0.910781316485549 0.932744754460012 0.0158534005392589 MirTarget -0.157674562090061 0.0194825738421652 NA NA NA hsa-miR-28-5p LRRC23 -0.0511712157419266 0.910958192291954 0.237078454778776 0.518386329719146 miRanda -0.250064616964937 0.000214648120768614 NA NA NA hsa-miR-197-3p LRRC27 0.0240027695773914 0.981971058073739 0.188962400586679 0.555990039328186 mirMAP -0.11879149114725 0.0119543989577703 NA NA NA hsa-miR-150-5p LRRC4 -0.00683324482969283 0.994067057151257 -0.162742709557659 0.710114957656744 miRNATAP -0.149346970927594 0.00153176138488805 NA NA NA hsa-miR-30e-5p LRRC40 -0.00273037859886571 0.997115479601006 0.0548984311981755 0.886519805848242 MirTarget -0.133207019552199 4.33646634141082e-05 NA NA NA hsa-miR-107 LRRK2 -0.289737369453023 0.769655185893943 0.0926174645890453 0.793802976019387 miRanda -0.244479966059499 0.015247332963176 NA NA NA hsa-miR-128-3p LRRN4CL -0.0364518492233463 0.95841670253784 0.521704293216385 0.141650024323726 MirTarget -0.428550579514194 1.86890384285846e-05 NA NA NA hsa-miR-16-5p LSM5 -0.199225750365017 0.742834324195084 0.113213724606268 0.805134353107365 miRNAWalker2_validate -0.115041285525914 0.00338152141196729 NA NA NA hsa-let-7a-5p LTA4H 0.0514604984725615 0.971564723582327 0.427184700748923 0.475630872976352 miRNAWalker2_validate -0.101602336819594 0.0330861568835693 NA NA NA hsa-miR-107 LTBP2 -0.289737369453023 0.769655185893943 0.181061839639702 0.795920603027057 miRanda -0.179367118687258 0.0179795060841582 NA NA NA hsa-miR-129-5p LTBP2 0.417083435812871 0.454236109516901 0.181061839639702 0.795920603027057 miRanda;miRNATAP -0.132500842507097 0.000659199725273215 NA NA NA hsa-miR-148a-5p LTBP2 -0.160202546137977 0.744679670526904 0.181061839639702 0.795920603027057 mirMAP -0.188469951698068 0.000540332052726626 NA NA NA hsa-miR-324-5p LTBP2 -0.358991607952497 0.499732551112182 0.181061839639702 0.795920603027057 miRanda -0.133217170309354 0.04679144805707 NA NA NA hsa-miR-335-3p LTBP2 0.0738544228922926 0.89349398283313 0.181061839639702 0.795920603027057 mirMAP -0.10132971302518 0.0345603357402165 NA NA NA hsa-miR-338-3p LTBP2 -0.107178830331044 0.818042702366464 0.181061839639702 0.795920603027057 miRanda -0.149211448778394 0.000413222199923471 NA NA NA hsa-miR-636 LTBP2 -0.112545138850734 0.710621887575005 0.181061839639702 0.795920603027057 PITA -0.130563254627645 0.0156757376420501 NA NA NA hsa-miR-760 LTC4S -0.149600635966191 0.803293629709251 0.648483349948658 0.0999845026611999 miRNATAP -0.195854439040355 0.000587447883415925 NA NA NA hsa-miR-148a-3p LYNX1 -0.324144803192141 0.746264759480212 -0.620204138635312 0.323199147587821 mirMAP -0.306408111408694 0.0122505118885525 NA NA NA hsa-miR-125a-5p LYPLA1 -0.00666761469427968 0.994891296705929 0.0142284569514279 0.981003248001069 miRNAWalker2_validate -0.221480906217949 0.000276104007948613 NA NA NA hsa-miR-195-3p LYPLA1 -0.156258661515859 0.711891893678154 0.0142284569514279 0.981003248001069 mirMAP -0.101560988764263 0.000996266860104304 NA NA NA hsa-miR-15b-5p LYPLA2 0.251826642099145 0.790709218602499 0.0466380521271166 0.933883858584386 miRNATAP -0.11919574403544 0.0066780418804974 NA NA NA hsa-miR-221-3p LYSMD1 -0.261179092929062 0.744019631321393 0.0459177665208772 0.905657122423434 miRNAWalker2_validate -0.189150766146668 6.87065120620259e-10 NA NA NA hsa-miR-125a-3p LZTFL1 0.124026360619668 0.800539414590835 0.0938657701335224 0.847382998302942 miRanda -0.109837287442299 0.0219431964351463 NA NA NA hsa-miR-185-5p LZTFL1 -0.646398728237327 0.117918763555657 0.0938657701335224 0.847382998302942 MirTarget -0.176847701174478 1.67366696479676e-07 NA NA NA hsa-miR-186-5p LZTFL1 -0.246324984406451 0.701310703524093 0.0938657701335224 0.847382998302942 MirTarget -0.116436412047315 0.010589875738724 NA NA NA hsa-miR-21-5p LZTFL1 -0.515762857245393 0.64198914412298 0.0938657701335224 0.847382998302942 MirTarget -0.133287422832533 6.84729509949409e-08 NA NA NA hsa-miR-576-5p LZTFL1 -0.521065838204864 0.11793493718786 0.0938657701335224 0.847382998302942 MirTarget;mirMAP -0.107027079525289 0.000545224566378236 NA NA NA hsa-miR-363-3p MACC1 -0.186046567396088 0.728622856049059 0.260220928613358 0.652024072027222 mirMAP -0.205241069490029 0.000258209358002278 NA NA NA hsa-miR-28-5p MAD2L1 -0.0511712157419266 0.910958192291954 -0.14590501482212 0.730104611980009 miRanda -0.155211339976619 0.0181449635787341 NA NA NA hsa-miR-148a-3p MAF1 -0.324144803192141 0.746264759480212 0.103224605469632 0.883532262252436 MirTarget;miRNATAP -0.102425630268453 0.00601704673884222 NA NA NA hsa-miR-139-5p MAGEF1 -0.0625698939687087 0.914810329989088 -0.0119118806789968 0.982790817036665 miRanda -0.105487167552931 0.00256995859798472 NA NA NA hsa-miR-22-3p MAGI2 0.0468440219945929 0.967778504781139 -0.00790751687369751 0.980258124097068 MirTarget -0.14276229279922 0.00116937953752452 NA NA NA hsa-miR-365a-3p MAK 0.343543107096282 0.577093517084808 -0.424446748774178 0.203781832662384 MirTarget -0.250163358865496 0.0213510524868819 NA NA NA hsa-miR-589-5p MAK -0.181894068226246 0.778993585147379 -0.424446748774178 0.203781832662384 miRNATAP -0.212470331433832 0.0193387966271466 NA NA NA hsa-miR-107 MAMSTR -0.289737369453023 0.769655185893943 0.332155827435769 0.408542067111864 miRNATAP -0.337006366289374 0.000154244666438632 NA NA NA hsa-miR-15b-5p MAMSTR 0.251826642099145 0.790709218602499 0.332155827435769 0.408542067111864 MirTarget;miRNATAP -0.202307254292015 0.0294693578130639 NA NA NA hsa-miR-107 MAN1A1 -0.289737369453023 0.769655185893943 0.22194050554855 0.658159205811332 miRanda -0.222913335870863 0.0192902062689581 NA NA NA hsa-miR-425-5p MAN1C1 -0.260590453490611 0.72116723892515 0.142757708714975 0.714089966523161 MirTarget -0.133388531958477 0.0279872760318634 NA NA NA hsa-miR-27a-3p MANEAL 0.309634509674364 0.703724209648479 0.149925274189369 0.733611157474911 miRNATAP -0.35870596048083 1.08050486043473e-05 NA NA NA hsa-miR-22-3p MAOA 0.0468440219945929 0.967778504781139 0.216267758614028 0.608331488431146 miRNAWalker2_validate;miRTarBase -0.160485811449646 0.026734024832982 NA NA NA hsa-miR-224-5p MAOA -0.143123534787342 0.827443367193551 0.216267758614028 0.608331488431146 MirTarget -0.190086920159499 6.37616411350254e-07 NA NA NA hsa-miR-222-3p MAP3K10 -0.233673471709747 0.726651775432807 -0.291204049416834 0.452237345842688 MirTarget;miRNATAP -0.106867913997144 0.0169617473011264 NA NA NA hsa-let-7b-3p MAP4K3 0.314328399485033 0.684245834514538 0.236096116206809 0.619049014137265 mirMAP -0.10417902479046 0.000360882228721789 NA NA NA hsa-let-7d-5p MAP4K3 0.0119393569456978 0.988390093874148 0.236096116206809 0.619049014137265 MirTarget;miRNATAP -0.118380408484829 0.000136884177015363 NA NA NA hsa-let-7i-5p MAP4K3 -0.0940710536612883 0.902310710205355 0.236096116206809 0.619049014137265 MirTarget;miRNATAP -0.128136793641493 1.79762245497607e-05 NA NA NA hsa-miR-155-5p MAP4K3 -0.320577372003167 0.673183036961734 0.236096116206809 0.619049014137265 MirTarget -0.106243568427419 7.79001437836116e-07 NA NA NA hsa-miR-186-5p MAP4K3 -0.246324984406451 0.701310703524093 0.236096116206809 0.619049014137265 miRNATAP -0.144759751317143 3.76766660985209e-05 NA NA NA hsa-miR-21-3p MAP4K3 0.129101420041684 0.877913267462969 0.236096116206809 0.619049014137265 MirTarget -0.102164395871283 3.67300868499733e-06 NA NA NA hsa-miR-98-5p MAP4K4 -0.0484028619275874 0.910781316485549 -0.0311215233337272 0.957041209829705 MirTarget -0.127281230301707 2.4953225605467e-05 NA NA NA hsa-miR-146b-5p MAPK10 0.0340352805627226 0.964565988329585 0.523870197809813 0.235148628130106 miRanda -0.170246578554128 0.0450975450674226 NA NA NA hsa-miR-221-3p MAPK10 -0.261179092929062 0.744019631321393 0.523870197809813 0.235148628130106 miRNATAP -0.393525241288137 8.94266232587406e-05 NA NA NA hsa-miR-222-3p MAPK10 -0.233673471709747 0.726651775432807 0.523870197809813 0.235148628130106 miRNATAP -0.373438856768302 0.000182016627023444 NA NA NA hsa-miR-29a-3p MAPK10 0.203872357562561 0.859946061784007 0.523870197809813 0.235148628130106 miRNATAP -0.456004556492144 9.36159159796716e-06 NA NA NA hsa-miR-29b-3p MAPK10 -0.249746665931503 0.558208927436524 0.523870197809813 0.235148628130106 miRNATAP -0.306202064859898 2.6834803761326e-05 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-29c-3p MAPK10 0.042533372292219 0.941334605544826 0.523870197809813 0.235148628130106 miRNATAP -0.315267581513467 0.000181324269376378 NA NA NA hsa-miR-30e-3p MAPK10 0.202355073367528 0.857417040078429 0.523870197809813 0.235148628130106 mirMAP -0.510831102336005 0.000198199376621255 NA NA NA hsa-miR-330-3p MAPK10 -0.1562229971038 0.692313620862782 0.523870197809813 0.235148628130106 PITA;miRNATAP -0.379650859930523 0.000177673408186751 NA NA NA hsa-miR-429 MAPK10 -0.596617415946644 0.128967410286089 0.523870197809813 0.235148628130106 miRNATAP -0.265049166813728 0.00143732530920345 NA NA NA hsa-miR-107 MAPRE2 -0.289737369453023 0.769655185893943 0.0919708322527146 0.82595480910976 miRanda -0.120042625634459 0.0121849151522671 NA NA NA hsa-miR-27a-3p MAPT 0.309634509674364 0.703724209648479 0.0350134460924524 0.92874988474302 miRNATAP -0.245482615237444 0.0132295882816802 NA NA NA hsa-miR-101-3p MARCKSL1 -0.0149915187591869 0.981999725022451 -0.226914245018422 0.759837417353944 miRNATAP -0.200098157150874 0.00010743612076163 NA NA NA hsa-miR-1266-5p MARCKSL1 0.193428002960802 0.749720354543557 -0.226914245018422 0.759837417353944 MirTarget -0.149368004341056 0.00104024791901736 NA NA NA hsa-miR-23a-3p MARCKSL1 0.174045248211037 0.865717934161724 -0.226914245018422 0.759837417353944 MirTarget -0.299576902484169 4.15312482230022e-07 NA NA NA hsa-miR-23b-3p MARCKSL1 0.188949711826471 0.848360545615343 -0.226914245018422 0.759837417353944 MirTarget;miRNATAP -0.210175300874932 0.000112810874287314 NA NA NA hsa-miR-24-3p MARCKSL1 0.0408517902063537 0.966828370841971 -0.226914245018422 0.759837417353944 miRNAWalker2_validate;MirTarget;miRNATAP -0.284475656721978 1.49760092313074e-06 NA NA NA hsa-miR-30b-3p MARCKSL1 -0.231361964211179 0.496038769366155 -0.226914245018422 0.759837417353944 MirTarget;miRNATAP -0.175069315689471 0.00034022492253623 NA NA NA hsa-miR-330-5p MARCKSL1 -0.152605584680815 0.787259112745893 -0.226914245018422 0.759837417353944 miRanda -0.189339852106892 0.000288166946987465 NA NA NA hsa-miR-34a-5p MARCKSL1 -0.689845719362998 0.195745632660671 -0.226914245018422 0.759837417353944 MirTarget;miRNATAP -0.174795472618051 8.47555696230991e-05 NA NA NA hsa-let-7b-5p MARS 0.396604576702067 0.783406687058469 -0.148404703023964 0.801134615792965 miRNAWalker2_validate -0.186488083898045 1.8574791484612e-11 NA NA NA hsa-miR-222-3p MARS -0.233673471709747 0.726651775432807 -0.148404703023964 0.801134615792965 miRNAWalker2_validate -0.112568624035877 4.37599241036931e-05 NA NA NA hsa-miR-92a-3p MARS 0.0155161307487504 0.991444817308063 -0.148404703023964 0.801134615792965 miRNAWalker2_validate -0.147083506168354 0.000100433444211931 NA NA NA hsa-miR-140-3p MARVELD2 -0.105651799466207 0.9077781740714 -0.144681662924778 0.696407165274861 miRNATAP -0.137938899646056 0.00491457511068791 NA NA NA hsa-miR-15b-5p MASP1 0.251826642099145 0.790709218602499 -0.909621259614214 0.0597362156882121 MirTarget -0.527685974429099 0.000262913248327023 NA NA NA hsa-miR-129-5p MAST4 0.417083435812871 0.454236109516901 -0.145795153930399 0.746409447124093 mirMAP;miRNATAP -0.118215640073287 0.00248136527969799 NA NA NA hsa-miR-25-3p MAST4 0.0681841609869576 0.955267320175687 -0.145795153930399 0.746409447124093 miRNATAP -0.220957831678716 0.00927200550545608 NA NA NA hsa-miR-28-3p MAST4 0.0964925270967019 0.928391906694323 -0.145795153930399 0.746409447124093 mirMAP -0.194477401097119 0.040985689488303 NA NA NA hsa-miR-324-3p MAST4 -0.244363119878663 0.713004048957448 -0.145795153930399 0.746409447124093 miRNAWalker2_validate -0.228649040307079 0.00400668938604385 NA NA NA hsa-miR-616-5p MAST4 -0.321509218120179 0.271446046739636 -0.145795153930399 0.746409447124093 mirMAP -0.142808394014398 0.00638853420333053 NA NA NA hsa-miR-92b-3p MAST4 0.454620627632174 0.646193882241421 -0.145795153930399 0.746409447124093 miRNATAP -0.124451185999436 0.0187007837989603 NA NA NA hsa-miR-381-3p MAT2B 0.269633663970002 0.562625029053898 0.118747206326431 0.840236308314421 MirTarget -0.130818855838947 1.96607030437342e-06 NA NA NA hsa-miR-107 MBNL2 -0.289737369453023 0.769655185893943 0.328924240652993 0.560738790022646 miRanda;miRNATAP -0.158873149146417 0.000329364629550666 NA NA NA hsa-miR-15b-5p MBNL2 0.251826642099145 0.790709218602499 0.328924240652993 0.560738790022646 MirTarget -0.146472514499701 0.00141344651961067 NA NA NA hsa-miR-150-5p MCF2L -0.00683324482969283 0.994067057151257 -0.278288322912854 0.528025134614079 mirMAP -0.114276385624372 0.00907908934944747 NA NA NA hsa-miR-34a-5p MCM10 -0.689845719362998 0.195745632660671 -0.296153887055576 0.431106076927176 miRNAWalker2_validate -0.116316570758144 0.0435014049459078 NA NA NA hsa-miR-222-3p MCM3 -0.233673471709747 0.726651775432807 -0.325905981227457 0.583969057337992 miRNAWalker2_validate -0.102939232578558 0.00539214960164398 NA NA NA hsa-let-7b-5p MCM7 0.396604576702067 0.783406687058469 -0.21704844343859 0.731614992624178 miRNAWalker2_validate -0.165068369969833 8.02520386627541e-06 NA NA NA hsa-miR-222-3p MCM7 -0.233673471709747 0.726651775432807 -0.21704844343859 0.731614992624178 miRNAWalker2_validate -0.128923317932551 0.000345244045848528 NA NA NA hsa-miR-98-5p MDFI -0.0484028619275874 0.910781316485549 0.0864656344520851 0.871837354414125 MirTarget -0.224402855526144 0.00623505600009333 NA NA NA hsa-miR-148a-3p MDGA2 -0.324144803192141 0.746264759480212 -0.643726142335592 0.27054027920652 miRNATAP -0.245901763109445 0.0406840196685085 NA NA NA hsa-miR-22-3p MECOM 0.0468440219945929 0.967778504781139 0.104531166144888 0.866398503213567 miRNATAP -0.175139796434344 0.0019815004335689 NA NA NA hsa-miR-107 MECP2 -0.289737369453023 0.769655185893943 -0.26581565012751 0.64682167391541 mirMAP -0.102339996690988 0.00812726681711117 NA NA NA hsa-let-7a-5p MED28 0.0514604984725615 0.971564723582327 0.0587734083746225 0.902028708291418 TargetScan -0.206811187550911 2.57453995821505e-05 NA NA NA hsa-let-7b-5p MED28 0.396604576702067 0.783406687058469 0.0587734083746225 0.902028708291418 miRNAWalker2_validate -0.17389601717555 6.46371879820888e-06 NA NA NA hsa-miR-145-3p MED28 0.289719315666929 0.379793801283532 0.0587734083746225 0.902028708291418 MirTarget -0.130335274729907 3.03436710004313e-05 NA NA NA hsa-miR-21-5p MED28 -0.515762857245393 0.64198914412298 0.0587734083746225 0.902028708291418 MirTarget -0.16749895704701 1.2766457768446e-09 NA NA NA hsa-miR-30b-5p MED28 -0.298771188216537 0.582864939841563 0.0587734083746225 0.902028708291418 MirTarget -0.136973936484884 0.000325301993745844 NA NA NA hsa-miR-326 MED28 0.307641210889423 0.653580115931293 0.0587734083746225 0.902028708291418 miRanda -0.110716706825568 0.000166440516987641 NA NA NA hsa-miR-330-5p MED28 -0.152605584680815 0.787259112745893 0.0587734083746225 0.902028708291418 miRanda -0.233853927389663 1.79448542404938e-08 NA NA NA hsa-miR-744-5p MED28 -0.168908767270826 0.802038726728767 0.0587734083746225 0.902028708291418 miRNAWalker2_validate -0.106329828160231 0.0309969922632701 NA NA NA hsa-miR-107 MEGF8 -0.289737369453023 0.769655185893943 -0.262187012335394 0.645341783030519 miRanda -0.16008418491317 0.0134396672758809 NA NA NA hsa-miR-335-3p MEGF9 0.0738544228922926 0.89349398283313 0.277581649889147 0.532171596877109 MirTarget;mirMAP -0.108559111684901 0.00047669328694682 NA NA NA hsa-miR-139-5p MEIS1 -0.0625698939687087 0.914810329989088 0.245909423215222 0.713447142638256 miRanda -0.131076054091319 0.005693663016557 NA NA NA hsa-miR-181a-5p MELK -0.0320774839604816 0.975806098950371 -0.0775477177799075 0.867963911323596 MirTarget -0.139109138939195 0.0447059865483304 NA NA NA hsa-miR-181c-5p MELK -0.262596734125804 0.645471285705202 -0.0775477177799075 0.867963911323596 MirTarget -0.176429820445362 0.00129430176196517 NA NA NA hsa-miR-181d-5p MELK -0.294264170071504 0.604392929232074 -0.0775477177799075 0.867963911323596 MirTarget -0.110104531269269 0.0228626197325122 NA NA NA hsa-miR-125a-5p MEMO1 -0.00666761469427968 0.994891296705929 0.2077184545046 0.60931233587487 miRanda -0.229726871119734 6.06748610423542e-06 NA NA NA hsa-miR-107 MEOX2 -0.289737369453023 0.769655185893943 2.32321245960112 0.000545275488870563 miRanda -0.548449291336062 0.00518470491320469 NA NA NA hsa-miR-107 MEST -0.289737369453023 0.769655185893943 0.0589598360878076 0.930112474194024 miRanda -0.180120451042304 0.0353599762587732 NA NA NA hsa-miR-151a-5p MEST -0.501947294939717 0.354833760007774 0.0589598360878076 0.930112474194024 MirTarget -0.22165158747031 0.00339836968371151 NA NA NA hsa-miR-155-5p MEST -0.320577372003167 0.673183036961734 0.0589598360878076 0.930112474194024 miRNAWalker2_validate -0.207260839274373 0.000178183199784183 NA NA NA hsa-miR-28-5p MEST -0.0511712157419266 0.910958192291954 0.0589598360878076 0.930112474194024 miRanda -0.210098041329633 0.0169079688602827 NA NA NA hsa-miR-29a-3p MEST 0.203872357562561 0.859946061784007 0.0589598360878076 0.930112474194024 MirTarget;miRNATAP -0.473732120797325 1.05114702444139e-12 NA NA NA hsa-miR-29b-3p MEST -0.249746665931503 0.558208927436524 0.0589598360878076 0.930112474194024 MirTarget;miRNATAP -0.294532498529502 5.82008113058231e-10 NA NA NA hsa-miR-29c-3p MEST 0.042533372292219 0.941334605544826 0.0589598360878076 0.930112474194024 MirTarget;miRNATAP -0.309016369927395 1.98381337409386e-08 NA NA NA hsa-miR-664a-3p MEST -0.139841943049965 0.800834383581795 0.0589598360878076 0.930112474194024 MirTarget -0.472861897978119 4.88842866430256e-10 NA NA NA hsa-miR-107 METTL9 -0.289737369453023 0.769655185893943 0.143827503135352 0.811836337139752 miRanda -0.105008473320978 0.00467856757228112 NA NA NA hsa-miR-150-5p MEX3A -0.00683324482969283 0.994067057151257 -0.515964067558559 0.36569876644874 MirTarget -0.157252282511819 9.77907483803316e-05 NA NA NA hsa-miR-221-3p MEX3A -0.261179092929062 0.744019631321393 -0.515964067558559 0.36569876644874 MirTarget -0.397247161082086 1.30055715019131e-09 NA NA NA hsa-miR-222-3p MEX3A -0.233673471709747 0.726651775432807 -0.515964067558559 0.36569876644874 MirTarget -0.41379636443817 1.63787256383105e-10 NA NA NA hsa-miR-15b-5p MEX3B 0.251826642099145 0.790709218602499 0.0580753246251327 0.853583579699043 mirMAP -0.163562559464641 0.0472183624507341 NA NA NA hsa-miR-29a-3p MFAP2 0.203872357562561 0.859946061784007 0.390746300773172 0.554497594595892 miRNATAP -0.50946840185254 4.19850055369523e-08 NA NA NA hsa-miR-29b-3p MFAP2 -0.249746665931503 0.558208927436524 0.390746300773172 0.554497594595892 miRNATAP -0.372518215519334 1.37446490956925e-08 NA NA NA hsa-miR-29c-3p MFAP2 0.042533372292219 0.941334605544826 0.390746300773172 0.554497594595892 miRNATAP -0.359447676691678 2.38473916210993e-06 NA NA NA hsa-miR-30e-3p MFAP4 0.202355073367528 0.857417040078429 1.33288586085099 0.0389133238313738 MirTarget -0.433453140729299 0.00523233771755306 NA NA NA hsa-miR-939-5p MFAP4 -0.00957793796296125 0.973362007496516 1.33288586085099 0.0389133238313738 MirTarget -0.324294081394727 0.0200079301144813 NA NA NA hsa-miR-125a-5p MFN1 -0.00666761469427968 0.994891296705929 -0.0611749603328553 0.906371475065258 miRanda -0.154919519260449 0.00313083584998594 NA NA NA hsa-miR-98-5p MGAT3 -0.0484028619275874 0.910781316485549 -0.391474485907282 0.46172217806179 mirMAP -0.162370724718604 0.017632778879122 NA NA NA hsa-miR-106b-5p MGLL -0.3941595235172 0.389635342155994 -0.0794871073221683 0.886215478500122 miRNATAP -0.293068412755734 0.000213450110391055 NA NA NA hsa-miR-129-5p MGLL 0.417083435812871 0.454236109516901 -0.0794871073221683 0.886215478500122 MirTarget;miRanda;miRNATAP -0.124308864365088 0.00439624726837753 NA NA NA hsa-miR-18a-3p MGLL -0.188202012159778 0.618004963641688 -0.0794871073221683 0.886215478500122 MirTarget -0.257236623724306 0.000267640055888449 NA NA NA hsa-miR-25-3p MGLL 0.0681841609869576 0.955267320175687 -0.0794871073221683 0.886215478500122 mirMAP -0.414666868642223 9.70424073973387e-06 NA NA NA hsa-miR-324-3p MGLL -0.244363119878663 0.713004048957448 -0.0794871073221683 0.886215478500122 mirMAP -0.339009207757997 0.000120821117680474 NA NA NA hsa-miR-636 MGLL -0.112545138850734 0.710621887575005 -0.0794871073221683 0.886215478500122 mirMAP -0.211394335216866 0.000435601351685493 NA NA NA hsa-miR-760 MGLL -0.149600635966191 0.803293629709251 -0.0794871073221683 0.886215478500122 mirMAP -0.101355030429585 0.0405120049806669 NA NA NA hsa-miR-15b-5p MIB1 0.251826642099145 0.790709218602499 0.0258197040377963 0.955757277760357 miRNATAP -0.139386057807101 0.0015603320502765 NA NA NA hsa-miR-15b-5p MIPOL1 0.251826642099145 0.790709218602499 -0.0846346501667381 0.770324570800397 MirTarget -0.202206594050164 0.00928082058260099 NA NA NA hsa-miR-200c-3p MITF -0.333638625701646 0.813830738880144 0.391553110361002 0.271103089431506 miRNATAP -0.126948558270477 0.00906233991937846 NA NA NA hsa-miR-335-3p MITF 0.0738544228922926 0.89349398283313 0.391553110361002 0.271103089431506 mirMAP -0.136911369462451 0.00196155699964756 NA NA NA hsa-miR-92a-3p MITF 0.0155161307487504 0.991444817308063 0.391553110361002 0.271103089431506 miRNATAP -0.150684129800995 0.0450771709430912 NA NA NA hsa-miR-328-3p MKI67 0.326635455247326 0.676255782778498 -0.0209925018961927 0.973657568683332 miRNAWalker2_validate -0.132876135011595 0.0266961184232327 NA NA NA hsa-miR-664a-3p MKI67 -0.139841943049965 0.800834383581795 -0.0209925018961927 0.973657568683332 mirMAP -0.358974860853195 6.0645504182056e-09 NA NA NA hsa-miR-15b-5p MLXIP 0.251826642099145 0.790709218602499 -0.162080780703973 0.772024529124195 mirMAP -0.143171099360687 0.00316467646727878 NA NA NA hsa-miR-15b-5p MLYCD 0.251826642099145 0.790709218602499 0.0845276471539211 0.803177508059747 MirTarget -0.156905645954771 0.000137923507197141 NA NA NA hsa-miR-148a-3p MMD -0.324144803192141 0.746264759480212 0.240412246237321 0.579766828845087 miRNATAP -0.1144640846148 0.0498720966174475 NA NA NA hsa-miR-107 MMP16 -0.289737369453023 0.769655185893943 -0.379593897846034 0.297169015601653 PITA;miRanda;mirMAP -0.277773755159364 0.00779186874863781 NA NA NA hsa-miR-335-3p MMRN1 0.0738544228922926 0.89349398283313 0.169221329739469 0.689476383201374 MirTarget -0.210321164052253 0.00804993411465042 NA NA NA hsa-miR-107 MN1 -0.289737369453023 0.769655185893943 0.293503133520217 0.535647308694591 miRanda;miRNATAP -0.329196095740197 0.0045121643573116 NA NA NA hsa-miR-125a-3p MOSPD1 0.124026360619668 0.800539414590835 -0.0421232627933907 0.912282718576257 miRanda -0.153265044204309 0.00177742107351462 NA NA NA hsa-miR-107 MPND -0.289737369453023 0.769655185893943 0.101383537902284 0.787962047512557 miRanda -0.12293555208611 0.00869282811081548 NA NA NA hsa-miR-20a-5p MRPL13 -0.857283498361138 0.070259604943771 0.132377933161186 0.798847491341036 miRNAWalker2_validate -0.170846662289547 4.49705880467594e-07 NA NA NA hsa-miR-361-5p MRPL13 -0.278147578656315 0.728553069590798 0.132377933161186 0.798847491341036 miRanda -0.20526355282941 0.00505076128285095 NA NA NA hsa-miR-140-3p MRPL15 -0.105651799466207 0.9077781740714 0.13002151339712 0.82119768731574 MirTarget -0.14905095601708 0.000300258197309338 NA NA NA hsa-miR-197-3p MRPS21 0.0240027695773914 0.981971058073739 0.0492755104704878 0.933208833721286 MirTarget -0.159526489926726 0.00808585886689627 NA NA NA hsa-miR-21-5p MSH2 -0.515762857245393 0.64198914412298 0.114030645699373 0.826178347341347 miRNAWalker2_validate -0.1054422853827 2.66929412259327e-05 22806311;25991676;23372687;23904372 miR 21 induces cell cycle at S phase and modulates cell proliferation by down regulating hMSH2 in lung cancer; The aim of this study is to investigate the role of miR-21 in hMSH2 gene expression and the effect of miR-21 on cell proliferation and cell cycle in lung cancer; The targets of miR-21 were predicted by a bioinformatics tool and hMSH2 was validated as a direct target of miR-21 by luciferase activity assay; MiRNA mimics or inhibitors were used to stimulate or attenuate the effect of endogenous miR-21 on hMSH2 expression; MiR-21 and hMSH2 expressions were assessed with real-time RT-PCR and Western blotting; MiR-21 expression was inversely correlated with hMSH2 expression in human lung cancer cell lines; Further validation showed hMSH2 was directly regulated by miR-21; These data suggest miR-21 is a key regulator of hMSH2 and modulates cell cycle and proliferation by targeting hMSH2 in human lung cancer;In this study using reverse phase protein arrays RPPAs we assessed MPS1 mediated cell signaling pathways and demonstrated that inhibiting MPS1 could upregulate the expression of the tumor suppressor PDCD4 and MSH2 genes by down regulating micro RNA-21 miR-21; We also show the prognostic effect of miR21 PDCD4 and MSH2 levels to patient survival across different GBM molecular subtypes;Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MiR 21 mediates the radiation resistance of glioblastoma cells by regulating PDCD4 and hMSH2; In addition miR-21 knockdown increased the expression of endogenous PDCD4 and hMSH2 which contributed to the apoptosis and G2 arrest of T98G cells; The findings suggested that miR-21 may mediate the resistance of glioblastoma cells against radiation via its target genes PDCD4 and hMSH2 ;poor survival;;drug resistance lung cancer;glioblastoma;breast cancer;glioblastoma hsa-miR-128-3p MSRB3 -0.0364518492233463 0.95841670253784 0.651527293321505 0.134047439300427 MirTarget -0.232441151370909 0.00461796557095952 NA NA NA hsa-miR-107 MT1E -0.289737369453023 0.769655185893943 1.09495589125117 0.0879787099760846 miRanda -0.276627471048425 0.0437754797024939 NA NA NA hsa-miR-148a-3p MTMR9 -0.324144803192141 0.746264759480212 0.0188644934148083 0.953918308047657 miRNAWalker2_validate;MirTarget -0.104257798483369 0.00153348502800583 NA NA NA hsa-miR-15b-5p MTSS1 0.251826642099145 0.790709218602499 -0.0101321724379071 0.982409900942986 miRNATAP -0.256757587402273 0.000217307915332821 25783158;26743779 EGF induces microRNAs that target suppressors of cell migration: miR 15b targets MTSS1 in breast cancer; One of these miRNAs miR-15b targeted the 3' untranslated region of MTSS1 metastasis suppressor protein 1;High plasma miR-15b level and negative MTSS1 and Klotho expression in tumor tissues significantly correlated with poor survival; Inhibition of miR-15b activity by adenovirus carrying antimiR-15b sequence significantly increased MTSS1 and Klotho protein expression and subsequently decreased colony formation ability invasion and migration of HCT116 cells in vitro and liver metastasis of HCT116 tumors in vivo; In conclusion high abundance of circulating miR-15b correlated with tumor metastasis recurrence and poor patient prognosis through downregulation of MTSS1 and Klotho protein expression cell migration;metastasis;poor survival;metastasis;worse prognosis;recurrence breast cancer;colorectal cancer hsa-miR-128-3p MTSS1L -0.0364518492233463 0.95841670253784 -0.0538657103528779 0.920893759611299 MirTarget -0.10745761403911 0.0391839534897681 NA NA NA hsa-miR-107 MTUS1 -0.289737369453023 0.769655185893943 -0.00332238502862037 0.994561166135737 miRanda -0.117201541177076 0.0432698818109558 NA NA NA hsa-miR-107 MTUS2 -0.289737369453023 0.769655185893943 -0.380919764393437 0.339334726153731 miRanda;miRNATAP -0.447483789531952 0.000107913350047151 NA NA NA hsa-miR-107 MUM1L1 -0.289737369453023 0.769655185893943 0.0376543855064972 0.932627248899127 miRanda -0.274901222640474 0.0323231181172877 NA NA NA hsa-miR-148a-3p MUM1L1 -0.324144803192141 0.746264759480212 0.0376543855064972 0.932627248899127 MirTarget;miRNATAP -0.215594207390676 0.0345412736874207 NA NA NA hsa-miR-150-5p MUM1L1 -0.00683324482969283 0.994067057151257 0.0376543855064972 0.932627248899127 MirTarget -0.188036112994308 0.00199530068779277 NA NA NA hsa-miR-107 MXD4 -0.289737369453023 0.769655185893943 0.262063113999464 0.665352638416925 miRanda;miRNATAP -0.124350754011406 0.00594152243732408 NA NA NA hsa-miR-148a-3p MXRA7 -0.324144803192141 0.746264759480212 -0.0379244672390282 0.954076955491962 mirMAP -0.100799423251459 0.0275033713329146 NA NA NA hsa-miR-127-3p MYB 0.231539840651733 0.822108193638849 0.0332473030591585 0.938223116248872 miRanda -0.162171895479518 0.00537056619626271 NA NA NA hsa-miR-139-5p MYB -0.0625698939687087 0.914810329989088 0.0332473030591585 0.938223116248872 miRanda -0.23718899017367 0.00255084046020176 NA NA NA hsa-miR-181a-5p MYBL1 -0.0320774839604816 0.975806098950371 0.100436396863229 0.750891534234523 miRNATAP -0.187360237470562 0.00096799864494943 NA NA NA hsa-miR-181b-5p MYBL1 -0.0483087651223055 0.952929800264921 0.100436396863229 0.750891534234523 miRNATAP -0.144519440671645 0.00856593230307627 NA NA NA hsa-miR-181c-5p MYBL1 -0.262596734125804 0.645471285705202 0.100436396863229 0.750891534234523 miRNATAP -0.148066248763867 0.00104979634213938 NA NA NA hsa-miR-29a-3p MYBL2 0.203872357562561 0.859946061784007 -0.175691018238118 0.77228097022119 miRNATAP -0.432307588380751 2.97582885249709e-10 24289849 We further found that Mir-29a negatively regulated expression of B-Myb which is a transcription factor associated with tumorigenesis; Our data also suggests that Mir-29a may suppress tumor growth through down-regulating B-Myb tumorigenesis breast cancer hsa-miR-29b-3p MYBL2 -0.249746665931503 0.558208927436524 -0.175691018238118 0.77228097022119 miRNATAP -0.141590901670143 0.00452860745151144 NA NA NA hsa-miR-29c-3p MYBL2 0.042533372292219 0.941334605544826 -0.175691018238118 0.77228097022119 miRNATAP -0.137405801634302 0.0169303319498766 NA NA NA hsa-miR-30a-5p MYBL2 -0.163405499812159 0.87950357765238 -0.175691018238118 0.77228097022119 MirTarget;miRNATAP -0.154131232858738 0.0167550773260506 NA NA NA hsa-miR-30b-5p MYBL2 -0.298771188216537 0.582864939841563 -0.175691018238118 0.77228097022119 MirTarget -0.170248167663111 0.0137729633563229 NA NA NA hsa-miR-30c-2-3p MYBL2 -0.0384523361217557 0.953899540425972 -0.175691018238118 0.77228097022119 MirTarget -0.124116501847584 0.0482929558907965 NA NA NA hsa-miR-30c-5p MYBL2 -0.183013966936985 0.833177718550926 -0.175691018238118 0.77228097022119 MirTarget;miRNATAP -0.198810835800246 0.021707686097006 NA NA NA hsa-miR-30d-5p MYBL2 -0.127037899273548 0.917197761243139 -0.175691018238118 0.77228097022119 MirTarget;miRNATAP -0.311926214434068 0.000184494412784491 NA NA NA hsa-miR-30e-5p MYBL2 -0.00273037859886571 0.997115479601006 -0.175691018238118 0.77228097022119 miRTarBase;MirTarget -0.22407247748413 0.0075345735923762 NA NA NA hsa-miR-107 MYCN -0.289737369453023 0.769655185893943 0.228799689543911 0.667541591931963 miRanda -0.323128197424988 0.0137300141812264 NA NA NA hsa-miR-107 MYH11 -0.289737369453023 0.769655185893943 0.296909635940923 0.58051536799149 miRanda -0.323257678549824 0.0120087324748217 NA NA NA hsa-miR-129-5p MYH11 0.417083435812871 0.454236109516901 0.296909635940923 0.58051536799149 miRanda -0.135375504470358 0.0417973807658455 NA NA NA hsa-miR-107 MYL12B -0.289737369453023 0.769655185893943 0.411398842328717 0.563308075820262 miRanda -0.14781949369509 0.000924054591083789 NA NA NA hsa-miR-221-3p MYLIP -0.261179092929062 0.744019631321393 -0.182670852365389 0.725986214497763 MirTarget -0.100230553812015 0.00600353592968708 NA NA NA hsa-miR-200b-3p MYLK -0.532909690027328 0.555970111970307 0.297064160504854 0.630574459579197 TargetScan -0.177476240601073 6.63329085796479e-05 NA NA NA hsa-miR-429 MYLK -0.596617415946644 0.128967410286089 0.297064160504854 0.630574459579197 PITA;miRanda;miRNATAP -0.105112143518757 0.0180395023522447 NA NA NA hsa-miR-505-5p MYO10 -0.193966680796757 0.675835993908529 -0.0146107147213295 0.982201729332595 MirTarget -0.142025653187983 0.0367182415417606 NA NA NA hsa-miR-29b-1-5p MYO1B -0.188524660858621 0.603438322810761 -0.622084617985634 0.194942542894703 MirTarget -0.15562322550944 0.00178760008270918 NA NA NA hsa-miR-378a-5p MYO1B -0.031968081769751 0.969717820343558 -0.622084617985634 0.194942542894703 miRNAWalker2_validate -0.107351662154569 0.0207255172569741 NA NA NA hsa-miR-664a-3p MYO1B -0.139841943049965 0.800834383581795 -0.622084617985634 0.194942542894703 mirMAP -0.232448377262555 0.000144428874001644 NA NA NA hsa-miR-129-5p MYO5C 0.417083435812871 0.454236109516901 0.0308238387792423 0.952112608390246 mirMAP -0.102715261677863 0.00170937188272444 NA NA NA hsa-miR-324-5p MYO5C -0.358991607952497 0.499732551112182 0.0308238387792423 0.952112608390246 miRanda -0.154848338527997 0.00581201733300513 NA NA NA hsa-miR-342-3p MYO5C -0.233020179388453 0.739959578456401 0.0308238387792423 0.952112608390246 miRanda -0.136192215531279 0.023114692388407 NA NA NA hsa-miR-760 MYO5C -0.149600635966191 0.803293629709251 0.0308238387792423 0.952112608390246 MirTarget -0.131196374728896 0.000378784455136624 NA NA NA hsa-miR-27a-3p MYOCD 0.309634509674364 0.703724209648479 -0.711731299560881 0.210427017883159 miRNATAP -0.291538595958444 0.0470639056622417 NA NA NA hsa-miR-15b-5p MYRIP 0.251826642099145 0.790709218602499 -0.125991294654411 0.73886321574633 MirTarget -0.200223582618296 0.0421017696712115 NA NA NA hsa-miR-15b-5p N4BP1 0.251826642099145 0.790709218602499 -0.0959021532881064 0.857312114620154 miRNATAP -0.127979336902623 0.000244198632447609 NA NA NA hsa-miR-139-5p NAB2 -0.0625698939687087 0.914810329989088 -0.027108228126969 0.960319717501685 miRanda -0.129681312592998 0.000272215054826419 NA NA NA hsa-miR-660-5p NAP1L1 -0.561687438133488 0.138270972367544 0.376236804150212 0.610074183141145 MirTarget -0.117207501093516 6.15505491700052e-05 NA NA NA hsa-miR-128-3p NAP1L5 -0.0364518492233463 0.95841670253784 -0.0158416839941031 0.959606844813121 MirTarget -0.237219820129276 0.0040816651572671 NA NA NA hsa-miR-221-3p NAP1L5 -0.261179092929062 0.744019631321393 -0.0158416839941031 0.959606844813121 MirTarget;miRNATAP -0.127589537406286 0.0412340988263608 NA NA NA hsa-miR-197-3p NAPB 0.0240027695773914 0.981971058073739 -0.276799113439572 0.405987709254828 MirTarget -0.113486178564269 0.0143560749193208 NA NA NA hsa-miR-107 NAT14 -0.289737369453023 0.769655185893943 0.133418714326888 0.736110047821657 miRanda -0.28648497118462 6.04631269335041e-06 NA NA NA hsa-miR-148a-3p NAT14 -0.324144803192141 0.746264759480212 0.133418714326888 0.736110047821657 miRNATAP -0.135526059492213 0.00770486426269508 NA NA NA hsa-miR-107 NAT8L -0.289737369453023 0.769655185893943 -0.194610295745648 0.666510166719488 miRNATAP -0.198503709477065 0.0402027762452078 NA NA NA hsa-miR-140-3p NAT8L -0.105651799466207 0.9077781740714 -0.194610295745648 0.666510166719488 mirMAP -0.250360681343493 0.00472819942872071 NA NA NA hsa-miR-148a-3p NAT8L -0.324144803192141 0.746264759480212 -0.194610295745648 0.666510166719488 MirTarget -0.200584522524769 0.0088782220378639 NA NA NA hsa-miR-150-5p NAT8L -0.00683324482969283 0.994067057151257 -0.194610295745648 0.666510166719488 mirMAP -0.101374672805646 0.0275369092725084 NA NA NA hsa-miR-15b-5p NAT8L 0.251826642099145 0.790709218602499 -0.194610295745648 0.666510166719488 miRNATAP -0.318213492884822 0.00139946838933378 NA NA NA hsa-miR-214-3p NAT8L 0.0312810611346688 0.952640488671912 -0.194610295745648 0.666510166719488 MirTarget -0.118976874063757 0.0223545138034632 NA NA NA hsa-miR-660-5p NAT8L -0.561687438133488 0.138270972367544 -0.194610295745648 0.666510166719488 mirMAP -0.191083566424381 0.00152859258219449 NA NA NA hsa-let-7f-1-3p NBEA 0.131753980154284 0.686438107181988 -0.275712959870817 0.486362021902307 MirTarget -0.183048639147792 0.029724027009243 NA NA NA hsa-miR-128-3p NBEA -0.0364518492233463 0.95841670253784 -0.275712959870817 0.486362021902307 miRNAWalker2_validate -0.32813053772347 0.00526933358719167 NA NA NA hsa-miR-186-5p NBEA -0.246324984406451 0.701310703524093 -0.275712959870817 0.486362021902307 mirMAP -0.557132295724226 2.24709938540689e-06 NA NA NA hsa-miR-194-5p NBEA -0.141051051043955 0.809072276924359 -0.275712959870817 0.486362021902307 miRNATAP -0.270576351395724 0.0002133880330616 NA NA NA hsa-miR-21-5p NBEA -0.515762857245393 0.64198914412298 -0.275712959870817 0.486362021902307 miRNAWalker2_validate;miRNATAP -0.18618707517773 0.00474878011844622 NA NA NA hsa-miR-429 NBEA -0.596617415946644 0.128967410286089 -0.275712959870817 0.486362021902307 miRNATAP -0.187660927830254 0.0103260722362824 NA NA NA hsa-miR-93-5p NBEA -0.375078982324499 0.732311284477601 -0.275712959870817 0.486362021902307 MirTarget;miRNATAP -0.356728985117876 0.000390859028445362 NA NA NA hsa-miR-107 NBL1 -0.289737369453023 0.769655185893943 0.769799522387103 0.250444811249258 miRanda -0.344177987490751 9.1993885509739e-05 NA NA NA hsa-miR-222-3p NBPF3 -0.233673471709747 0.726651775432807 -0.276552256583735 0.394278443047512 MirTarget -0.100180671410591 0.0483671415927705 NA NA NA hsa-miR-146b-5p NCALD 0.0340352805627226 0.964565988329585 0.333888611733003 0.535344015865313 miRanda -0.121764942417325 0.028450150050048 NA NA NA hsa-miR-182-5p NCALD -0.262297863136789 0.8110070165759 0.333888611733003 0.535344015865313 miRNATAP -0.153507914092445 0.000902159892548971 NA NA NA hsa-miR-30a-5p NCALD -0.163405499812159 0.87950357765238 0.333888611733003 0.535344015865313 miRNATAP -0.208192449564908 0.000766217529883452 NA NA NA hsa-miR-30c-5p NCALD -0.183013966936985 0.833177718550926 0.333888611733003 0.535344015865313 miRNATAP -0.382053499371326 3.55670640178562e-06 NA NA NA hsa-miR-30e-5p NCALD -0.00273037859886571 0.997115479601006 0.333888611733003 0.535344015865313 miRNATAP -0.285786440370366 0.000387020785476086 NA NA NA hsa-let-7b-5p NCAPD2 0.396604576702067 0.783406687058469 -0.237057164680508 0.716551982661152 miRNAWalker2_validate -0.256939049510755 5.08171042887646e-10 NA NA NA hsa-miR-222-3p NCAPD2 -0.233673471709747 0.726651775432807 -0.237057164680508 0.716551982661152 miRNAWalker2_validate -0.147428798550067 0.000313873086953471 NA NA NA hsa-miR-664a-3p NCAPD2 -0.139841943049965 0.800834383581795 -0.237057164680508 0.716551982661152 MirTarget -0.250417696980107 1.22965659734462e-07 NA NA NA hsa-let-7b-5p NCAPG2 0.396604576702067 0.783406687058469 -0.217269087888229 0.636069409188441 miRNAWalker2_validate -0.124186709449935 0.00167071780011542 NA NA NA hsa-miR-125a-5p NCBP2 -0.00666761469427968 0.994891296705929 0.223223869254742 0.697817916709092 miRanda -0.123509825608082 0.0243578611272957 NA NA NA hsa-miR-107 NDFIP1 -0.289737369453023 0.769655185893943 0.218779692578825 0.74284234166211 miRanda -0.111059271922476 0.000423167071325736 NA NA NA hsa-miR-200b-3p NDN -0.532909690027328 0.555970111970307 0.0537975811833378 0.913392699733898 MirTarget;TargetScan -0.155867436207675 0.0258007435478093 NA NA NA hsa-miR-330-5p NDN -0.152605584680815 0.787259112745893 0.0537975811833378 0.913392699733898 miRanda -0.220328261128024 0.0185375239086636 NA NA NA hsa-miR-429 NDN -0.596617415946644 0.128967410286089 0.0537975811833378 0.913392699733898 MirTarget;PITA;miRanda;miRNATAP -0.267629573827208 9.63119823872381e-05 NA NA NA hsa-miR-338-3p NDP -0.107178830331044 0.818042702366464 -0.431728826330602 0.454386914582059 miRanda -0.194635738160849 0.0340699774330309 NA NA NA hsa-miR-660-5p NDST3 -0.561687438133488 0.138270972367544 -0.427897090227842 0.413882939364864 MirTarget -0.251860080733569 0.0102072387435228 NA NA NA hsa-miR-214-3p NDUFAF4 0.0312810611346688 0.952640488671912 0.114161597306842 0.783131150977471 MirTarget -0.108965324834893 4.09226347610003e-05 NA NA NA hsa-miR-363-3p NEBL -0.186046567396088 0.728622856049059 0.240365534867492 0.629156990841571 mirMAP -0.138509681939428 0.0103303178612246 NA NA NA hsa-miR-107 NEDD9 -0.289737369453023 0.769655185893943 0.450954311170567 0.422436334094576 MirTarget;PITA;miRanda;miRNATAP -0.182565099436603 0.046078683996587 NA NA NA hsa-miR-342-3p NEK11 -0.233020179388453 0.739959578456401 0.0204622586033749 0.956820390808607 miRanda -0.112160295973056 0.030485856269017 NA NA NA hsa-miR-27b-3p NEK2 0.306246927737414 0.735781270461428 -0.104848284002335 0.80610923275455 miRNATAP -0.23681001339815 0.000153297183899675 NA NA NA hsa-miR-98-5p NEK3 -0.0484028619275874 0.910781316485549 0.0355624330436375 0.902150967315788 miRNAWalker2_validate -0.153002795012835 3.64030629174472e-05 NA NA NA hsa-miR-429 NELL2 -0.596617415946644 0.128967410286089 -0.301548456365491 0.523729433404984 miRanda -0.318216734832202 0.00032190206255972 NA NA NA hsa-miR-193a-5p NETO2 0.237612077466578 0.806674211675518 -0.216357691802887 0.599039670948123 MirTarget;TargetScan -0.26422532229456 0.00332655937241484 NA NA NA hsa-miR-21-5p NETO2 -0.515762857245393 0.64198914412298 -0.216357691802887 0.599039670948123 miRNAWalker2_validate;mirMAP -0.11339412965038 0.0384285002479436 NA NA NA hsa-miR-24-3p NETO2 0.0408517902063537 0.966828370841971 -0.216357691802887 0.599039670948123 miRNAWalker2_validate -0.218076344630521 0.0198644908442983 NA NA NA hsa-miR-664a-3p NETO2 -0.139841943049965 0.800834383581795 -0.216357691802887 0.599039670948123 mirMAP -0.359316313210534 2.19003624856695e-05 NA NA NA hsa-miR-125b-5p NEU1 0.0074438975183444 0.994154663318355 0.165937539346626 0.78052010497944 miRNATAP -0.221936615658054 1.42415231278705e-07 27220320;25184537 STARD13 and NEU1 were identified as direct target genes of miR-125b by luciferase assays and they were involved in the cell migration and invasion regulated by miR-125b in gastric cancer;Thus far two of these target genes BBC3 and NEU1 that are tumor suppressor genes but not yet studied in PDAC appear to be functional targets of miR-125b since knockdown of miR125b caused their up regulation cell migration; gastric cancer;pancreatic cancer hsa-miR-15b-5p NFAT5 0.251826642099145 0.790709218602499 -0.0451008314815349 0.932558744469138 MirTarget -0.11832723278323 0.0212678314753098 NA NA NA hsa-miR-221-3p NFATC3 -0.261179092929062 0.744019631321393 -0.0467493749243486 0.918936458770211 MirTarget;miRNATAP -0.129625119146625 3.64656939307274e-05 NA NA NA hsa-miR-222-3p NFATC3 -0.233673471709747 0.726651775432807 -0.0467493749243486 0.918936458770211 MirTarget;miRNATAP -0.120080195297181 0.000119274873908316 NA NA NA hsa-miR-27a-3p NFIA 0.309634509674364 0.703724209648479 0.203437541070212 0.72842105764397 mirMAP;miRNATAP -0.115730916164154 0.0241026346003565 NA NA NA hsa-miR-107 NFIL3 -0.289737369453023 0.769655185893943 -0.039332104030386 0.928285049079243 miRanda -0.10408436090478 0.0251269051472641 NA NA NA hsa-miR-221-3p NFYA -0.261179092929062 0.744019631321393 -0.148815180274824 0.758816376090414 miRNAWalker2_validate -0.105290167893947 0.000653754005949671 NA NA NA hsa-miR-98-5p NGF -0.0484028619275874 0.910781316485549 0.0606947374867796 0.868848915772776 MirTarget -0.193090544409303 0.00656225416048939 NA NA NA hsa-miR-27a-3p NGFR 0.309634509674364 0.703724209648479 0.0808558734911828 0.87477900264211 miRNATAP -0.441499463546649 0.000582451228597517 NA NA NA hsa-miR-22-3p NHP2 0.0468440219945929 0.967778504781139 0.277553057333573 0.637211429118291 MirTarget -0.158469560721771 1.27373153233441e-05 NA NA NA hsa-miR-221-3p NHSL1 -0.261179092929062 0.744019631321393 -0.0218678157528194 0.957716277431275 miRNAWalker2_validate -0.110512002090797 0.0449916458235144 NA NA NA hsa-miR-107 NINJ1 -0.289737369453023 0.769655185893943 -0.201825946897513 0.71890145375678 miRNAWalker2_validate -0.121676045064141 0.00756263516102128 NA NA NA hsa-miR-15b-5p NISCH 0.251826642099145 0.790709218602499 -0.237663017300441 0.695375907186771 MirTarget -0.178322846983083 6.63893485193274e-05 NA NA NA hsa-miR-221-3p NLE1 -0.261179092929062 0.744019631321393 -0.0728060386186562 0.839273445612345 mirMAP -0.110295404172446 0.00148296343858819 NA NA NA hsa-miR-107 NLGN1 -0.289737369453023 0.769655185893943 -0.729553026296322 0.169812125294617 PITA;miRanda -0.328237375934883 0.0387444650251745 NA NA NA hsa-miR-148b-3p NLGN4X 0.0855166854239631 0.914712779298241 0.43837113920409 0.353125751827492 miRNAWalker2_validate -0.87581774379553 1.14940510120034e-09 NA NA NA hsa-miR-182-5p NLGN4X -0.262297863136789 0.8110070165759 0.43837113920409 0.353125751827492 miRNATAP -0.141541320018245 0.0346655549625213 NA NA NA hsa-miR-194-3p NLGN4X 0.012041841961977 0.978632170113365 0.43837113920409 0.353125751827492 MirTarget;miRNATAP -0.178863432070305 0.0413241733999768 NA NA NA hsa-miR-200c-3p NLGN4X -0.333638625701646 0.813830738880144 0.43837113920409 0.353125751827492 miRNATAP -0.247706785409162 0.00320438975814135 NA NA NA hsa-miR-26b-5p NLGN4X 0.16143906971203 0.790777916193478 0.43837113920409 0.353125751827492 miRNAWalker2_validate -0.436069048098923 0.000969980654325734 NA NA NA hsa-miR-374b-5p NLGN4X -0.267096820650889 0.470048956816 0.43837113920409 0.353125751827492 mirMAP -0.268827633225158 0.00219419831794283 NA NA NA hsa-miR-616-5p NLGN4X -0.321509218120179 0.271446046739636 0.43837113920409 0.353125751827492 mirMAP;miRNATAP -0.244197768300645 0.00352213960095827 NA NA NA hsa-miR-93-3p NLGN4X -0.0244435387315667 0.960677870662158 0.43837113920409 0.353125751827492 MirTarget;miRNATAP -0.439462708129477 0.000258194382166295 NA NA NA hsa-miR-221-3p NLK -0.261179092929062 0.744019631321393 -0.0636934459576137 0.869819748947338 MirTarget;miRNATAP -0.111554625598997 0.000232292135467114 NA NA NA hsa-miR-222-3p NLK -0.233673471709747 0.726651775432807 -0.0636934459576137 0.869819748947338 MirTarget;miRNATAP -0.143042927111369 1.6176286197191e-06 NA NA NA hsa-miR-27a-3p NMB 0.309634509674364 0.703724209648479 0.0428632842606596 0.905103585100286 MirTarget -0.128945113023678 0.0389093128118002 NA NA NA hsa-miR-197-3p NME2 0.0240027695773914 0.981971058073739 0.274812496001704 0.715911319862544 miRNAWalker2_validate -0.110706053662734 0.0381142018704608 NA NA NA hsa-miR-107 NME4 -0.289737369453023 0.769655185893943 0.248239189776092 0.66157357272234 miRanda -0.15618030110751 0.00345759985129285 NA NA NA hsa-miR-98-5p NME4 -0.0484028619275874 0.910781316485549 0.248239189776092 0.66157357272234 MirTarget -0.121391124865176 0.000572327671159482 NA NA NA hsa-miR-125a-3p NME7 0.124026360619668 0.800539414590835 0.320405912399777 0.401204556076234 miRanda -0.130095965802416 0.00663324579437333 NA NA NA hsa-miR-151a-3p NME7 -0.281256460812097 0.785995341812949 0.320405912399777 0.401204556076234 MirTarget -0.266072160091958 2.55202596597059e-10 NA NA NA hsa-miR-152-3p NME7 -0.00518835781888161 0.99248323637383 0.320405912399777 0.401204556076234 MirTarget -0.161998058327431 1.41285855713287e-07 NA NA NA hsa-miR-15b-5p NOB1 0.251826642099145 0.790709218602499 0.162540587218787 0.756736939793649 MirTarget -0.18143681424207 7.44398917356847e-05 NA NA NA hsa-miR-148a-3p NOG -0.324144803192141 0.746264759480212 1.1420266546623 0.0138928936282003 MirTarget;miRNATAP -0.290759916931689 0.00816771396122413 NA NA NA hsa-miR-27a-3p NOL4 0.309634509674364 0.703724209648479 -0.204306724760897 0.765361582972055 miRNATAP -0.365517749092226 0.00943716427879655 NA NA NA hsa-miR-107 NOS1 -0.289737369453023 0.769655185893943 -0.80405302170729 0.226452743510243 miRNATAP -0.478593745268794 0.0129445440557645 NA NA NA hsa-miR-221-3p NOVA1 -0.261179092929062 0.744019631321393 0.114222288412774 0.808366255333672 miRNATAP -0.407431251678011 0.000140789994580519 NA NA NA hsa-miR-222-3p NOVA1 -0.233673471709747 0.726651775432807 0.114222288412774 0.808366255333672 miRNATAP -0.441936005892396 3.01591364560783e-05 NA NA NA hsa-miR-27a-3p NOVA1 0.309634509674364 0.703724209648479 0.114222288412774 0.808366255333672 miRNATAP -0.373882685080197 0.00171907878407069 NA NA NA hsa-miR-107 NPAS2 -0.289737369453023 0.769655185893943 0.341541264882074 0.553127312805121 miRanda;miRNATAP -0.307539551488061 0.00296004436360406 NA NA NA hsa-miR-107 NPY1R -0.289737369453023 0.769655185893943 0.020202143431716 0.971189484353485 miRanda -0.482795955465455 0.00332939886462063 NA NA NA hsa-miR-197-3p NR2C2 0.0240027695773914 0.981971058073739 -0.26369044756531 0.612938320469627 MirTarget -0.149553384658997 0.000342577449294786 NA NA NA hsa-miR-130b-5p NR3C2 -0.318833907124358 0.508178803208229 -0.153523054880199 0.690364607467825 mirMAP -0.179117613768104 0.0333929291509665 NA NA NA hsa-miR-148b-3p NR3C2 0.0855166854239631 0.914712779298241 -0.153523054880199 0.690364607467825 miRNAWalker2_validate -0.251956704435852 0.0246222104362201 NA NA NA hsa-miR-335-3p NR3C2 0.0738544228922926 0.89349398283313 -0.153523054880199 0.690364607467825 mirMAP -0.167451655628443 0.00393917291038661 NA NA NA hsa-miR-148a-3p NRARP -0.324144803192141 0.746264759480212 -0.177230104045369 0.690572948752183 MirTarget -0.113750790971509 0.021087760932137 NA NA NA hsa-miR-27a-3p NRARP 0.309634509674364 0.703724209648479 -0.177230104045369 0.690572948752183 MirTarget -0.158446897840824 0.00336131041843081 NA NA NA hsa-miR-98-5p NRARP -0.0484028619275874 0.910781316485549 -0.177230104045369 0.690572948752183 MirTarget -0.123206615749009 0.0026318240974553 NA NA NA hsa-let-7a-5p NRAS 0.0514604984725615 0.971564723582327 -0.296549524086096 0.622788816254119 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.149070852665224 0.000165963359517393 20607356 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells glioblastoma hsa-let-7b-5p NRAS 0.396604576702067 0.783406687058469 -0.296549524086096 0.622788816254119 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.152944680514119 7.11382814512338e-07 20607356 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells glioblastoma hsa-let-7g-5p NRAS -0.320647530232065 0.660364346555039 -0.296549524086096 0.622788816254119 MirTarget;miRNATAP -0.100160602751118 0.00296727533762914 NA NA NA hsa-miR-27b-3p NRAS 0.306246927737414 0.735781270461428 -0.296549524086096 0.622788816254119 miRNATAP -0.147354953907454 4.2887193549508e-05 NA NA NA hsa-miR-29a-3p NRAS 0.203872357562561 0.859946061784007 -0.296549524086096 0.622788816254119 miRNATAP -0.144870125373982 3.03280937485811e-06 NA NA NA hsa-miR-664a-3p NRAS -0.139841943049965 0.800834383581795 -0.296549524086096 0.622788816254119 MirTarget -0.120195133870789 0.000688164261673464 NA NA NA hsa-miR-214-3p NRG4 0.0312810611346688 0.952640488671912 -0.0658483498830873 0.899494179878125 MirTarget -0.273074550211517 0.00106382908335362 NA NA NA hsa-miR-107 NRP2 -0.289737369453023 0.769655185893943 0.141402624157643 0.822387762668146 PITA;miRanda;miRNATAP -0.215004577030632 0.0236808730312418 NA NA NA hsa-miR-221-3p NSMCE4A -0.261179092929062 0.744019631321393 0.172981314666597 0.69491576255198 MirTarget -0.117998815923071 0.000135183669174312 NA NA NA hsa-miR-222-3p NSMCE4A -0.233673471709747 0.726651775432807 0.172981314666597 0.69491576255198 MirTarget -0.100255324095749 0.00112429688424157 NA NA NA hsa-let-7e-5p NT5DC2 -0.421901553764044 0.703151344854989 0.141424580891696 0.822040479986213 miRNAWalker2_validate -0.180112477825347 0.00104022402232152 NA NA NA hsa-miR-221-3p NT5DC2 -0.261179092929062 0.744019631321393 0.141424580891696 0.822040479986213 miRNAWalker2_validate -0.147468099501814 0.000818869648245789 NA NA NA hsa-miR-221-3p NTF3 -0.261179092929062 0.744019631321393 0.858728450070405 0.127020238221505 miRNATAP -0.309507169396291 0.0197614931510882 NA NA NA hsa-miR-222-3p NTF3 -0.233673471709747 0.726651775432807 0.858728450070405 0.127020238221505 miRNATAP -0.282887842785759 0.0318975394699351 NA NA NA hsa-miR-107 NTRK2 -0.289737369453023 0.769655185893943 0.132288227177412 0.755349144822091 PITA;miRanda -0.409395396926516 0.00030514186575642 NA NA NA hsa-miR-128-3p NTRK3 -0.0364518492233463 0.95841670253784 0.0833565341477112 0.900425585327201 miRNAWalker2_validate;miRTarBase -0.447381840542153 0.0297609938373558 NA NA NA hsa-miR-660-5p NTRK3 -0.561687438133488 0.138270972367544 0.0833565341477112 0.900425585327201 mirMAP -0.2467273088696 0.0462120296208033 NA NA NA hsa-miR-98-5p NTRK3 -0.0484028619275874 0.910781316485549 0.0833565341477112 0.900425585327201 mirMAP -0.428318523602906 0.000983169874204467 NA NA NA hsa-miR-26b-5p NUCB2 0.16143906971203 0.790777916193478 0.0600821025880727 0.901408422254786 miRNAWalker2_validate -0.144774508077359 0.0128315060257568 NA NA NA hsa-miR-107 NUDT11 -0.289737369453023 0.769655185893943 0.134265353309455 0.723884102669589 miRanda -0.335956532186566 0.00283286245590525 NA NA NA hsa-miR-22-3p NUDT4 0.0468440219945929 0.967778504781139 0.306947231961959 0.516273454611005 MirTarget;miRNATAP -0.147501991692451 0.00125398914911248 NA NA NA hsa-miR-221-3p NUF2 -0.261179092929062 0.744019631321393 0.0736115796363661 0.853426514695281 miRNAWalker2_validate -0.193520958235536 0.000248756283895222 NA NA NA hsa-miR-660-5p NUFIP1 -0.561687438133488 0.138270972367544 0.280463392837723 0.385469934405503 MirTarget -0.103968921435712 3.7725058735408e-05 NA NA NA hsa-let-7a-5p NUP155 0.0514604984725615 0.971564723582327 -0.154470678910887 0.729610438735704 TargetScan -0.132630480724586 0.00155743844298217 NA NA NA hsa-let-7b-5p NUP155 0.396604576702067 0.783406687058469 -0.154470678910887 0.729610438735704 miRNAWalker2_validate -0.163415391707707 5.08435806947143e-07 NA NA NA hsa-miR-139-5p NUP210 -0.0625698939687087 0.914810329989088 -0.314809898951629 0.613838467162813 miRanda -0.105600878225134 0.031675865543565 NA NA NA hsa-miR-30e-3p NUP62CL 0.202355073367528 0.857417040078429 0.0553110491124323 0.86966644246452 MirTarget -0.227207769245473 0.0337482039370389 NA NA NA hsa-let-7b-5p NUSAP1 0.396604576702067 0.783406687058469 0.0855976026723573 0.870236198067964 miRNAWalker2_validate -0.111331900321828 0.0268233576953478 NA NA NA hsa-miR-140-3p NXN -0.105651799466207 0.9077781740714 -0.271724906317887 0.663502292719552 PITA;miRNATAP -0.132234457848233 0.0233573709202194 NA NA NA hsa-miR-199a-5p OAS1 0.248253058498817 0.7461266806999 -0.239173594349372 0.701995086595271 miRanda -0.167920531426933 0.00257639770056301 NA NA NA hsa-miR-129-5p OAS2 0.417083435812871 0.454236109516901 -0.484310469837743 0.485972798030757 miRanda -0.122205964822842 0.0216400680943188 NA NA NA hsa-miR-125a-5p OAS3 -0.00666761469427968 0.994891296705929 -0.681814967144788 0.33698154760934 mirMAP -0.253127606439952 0.0377436049678964 NA NA NA hsa-miR-199a-5p OAS3 0.248253058498817 0.7461266806999 -0.681814967144788 0.33698154760934 miRanda -0.175085930146032 0.000744387362466542 NA NA NA hsa-miR-338-3p OAS3 -0.107178830331044 0.818042702366464 -0.681814967144788 0.33698154760934 miRanda -0.107521509248306 0.0298382883825602 NA NA NA hsa-miR-485-3p OAS3 0.260493747772693 0.658365017969425 -0.681814967144788 0.33698154760934 mirMAP -0.201372314755574 4.65979951957497e-06 NA NA NA hsa-miR-758-3p OAS3 0.345437123737534 0.427390340322462 -0.681814967144788 0.33698154760934 mirMAP -0.173496597481738 0.000173859481316291 NA NA NA hsa-let-7a-2-3p OASL 0.411024905124061 0.349899745787071 -0.610150919801774 0.247261804397099 MirTarget -0.203632362234137 0.00138035867946732 NA NA NA hsa-miR-199a-5p OASL 0.248253058498817 0.7461266806999 -0.610150919801774 0.247261804397099 miRanda -0.175099458107155 0.0123402953983421 NA NA NA hsa-miR-140-3p OCLN -0.105651799466207 0.9077781740714 -0.217929537829503 0.616601731262907 mirMAP -0.172702570737185 0.000267515648414945 NA NA NA hsa-miR-129-5p OGN 0.417083435812871 0.454236109516901 0.976668602985972 0.0778705605938321 miRanda -0.195842054809184 0.0151426358816137 NA NA NA hsa-miR-155-5p OGN -0.320577372003167 0.673183036961734 0.976668602985972 0.0778705605938321 miRNATAP -0.243864022932163 0.0166308567791825 NA NA NA hsa-miR-361-5p OGN -0.278147578656315 0.728553069590798 0.976668602985972 0.0778705605938321 miRanda;miRNATAP -0.417995091667297 0.0399889749546472 NA NA NA hsa-miR-140-3p OLA1 -0.105651799466207 0.9077781740714 -0.188608643524996 0.752947981569764 miRNATAP -0.180686270082275 6.29720829508017e-07 NA NA NA hsa-miR-221-3p OLA1 -0.261179092929062 0.744019631321393 -0.188608643524996 0.752947981569764 miRNATAP -0.114949307814663 0.000243025818380475 NA NA NA hsa-miR-222-3p OLA1 -0.233673471709747 0.726651775432807 -0.188608643524996 0.752947981569764 miRNAWalker2_validate -0.1132806471557 0.000268168315116966 NA NA NA hsa-miR-107 OLFM1 -0.289737369453023 0.769655185893943 -0.238801621884931 0.648057743193167 PITA;miRanda;miRNATAP -0.392155277833572 0.00924321662394775 NA NA NA hsa-miR-146b-5p OLFM4 0.0340352805627226 0.964565988329585 -0.110419925208184 0.900163862643363 miRanda -0.333347436504251 0.0435776166335847 NA NA NA hsa-miR-107 OLFML1 -0.289737369453023 0.769655185893943 0.305858300395963 0.475821100274389 miRanda -0.268451583566613 0.00263230840084081 NA NA NA hsa-miR-361-5p OLFML1 -0.278147578656315 0.728553069590798 0.305858300395963 0.475821100274389 miRanda -0.351952794094261 0.00241814723977429 NA NA NA hsa-miR-616-5p OLFML1 -0.321509218120179 0.271446046739636 0.305858300395963 0.475821100274389 MirTarget -0.142329635021057 0.0213008518161456 NA NA NA hsa-miR-27a-3p ONECUT2 0.309634509674364 0.703724209648479 -0.237278021663198 0.6379903055134 miRNATAP -0.29518534469693 0.0252039205612485 NA NA NA hsa-miR-15b-5p OPRL1 0.251826642099145 0.790709218602499 0.296845285588109 0.287638465712838 mirMAP -0.274922236420953 8.49277903984734e-05 NA NA NA hsa-miR-500a-5p OSBPL10 -0.232217839578781 0.516569510502181 0.379091842296318 0.453433635477619 mirMAP -0.119914978078345 0.00420097067584176 NA NA NA hsa-miR-107 OSBPL6 -0.289737369453023 0.769655185893943 -0.357919972365256 0.443939897583447 miRanda;miRNATAP -0.385146931617015 0.00522811138079396 NA NA NA hsa-miR-129-5p OSR2 0.417083435812871 0.454236109516901 0.15313135296506 0.758934017099623 miRanda -0.187548060843975 0.00193078037782458 NA NA NA hsa-miR-140-3p OTUB1 -0.105651799466207 0.9077781740714 0.0611181497931943 0.92987679933319 PITA -0.150586877357552 4.64640807127058e-08 NA NA NA hsa-miR-214-3p P4HTM 0.0312810611346688 0.952640488671912 0.0907735401146175 0.867011565546993 MirTarget -0.112311266640433 3.93791641878222e-06 NA NA NA hsa-miR-127-3p PA2G4 0.231539840651733 0.822108193638849 0.295654482705588 0.652943405419874 miRanda -0.107764904315686 1.6494719410002e-07 NA NA NA hsa-miR-132-3p PACRG -0.274411442405805 0.710467071857645 0.785044394526371 0.0652271685824175 MirTarget -0.301876222426951 0.00405506361102456 NA NA NA hsa-miR-143-3p PACRG -0.0563781562134498 0.961203490945368 0.785044394526371 0.0652271685824175 miRNATAP -0.193871627626437 0.0403804315044554 NA NA NA hsa-miR-1976 PACRG -0.0230660894943657 0.965467916612671 0.785044394526371 0.0652271685824175 MirTarget -0.354846159154681 0.00438515484264412 NA NA NA hsa-miR-212-3p PACRG -0.118513342558296 0.740632149411935 0.785044394526371 0.0652271685824175 MirTarget -0.479049769480468 6.97216975748391e-08 NA NA NA hsa-miR-224-5p PACRG -0.143123534787342 0.827443367193551 0.785044394526371 0.0652271685824175 MirTarget -0.266072824827629 2.46511393527091e-07 NA NA NA hsa-miR-330-3p PACRG -0.1562229971038 0.692313620862782 0.785044394526371 0.0652271685824175 PITA -0.360644881088035 0.000325543285125931 NA NA NA hsa-miR-361-3p PACRG -0.398826925662302 0.617283381786186 0.785044394526371 0.0652271685824175 PITA -0.414175664710779 0.00136294248087881 NA NA NA hsa-miR-23a-3p PAFAH1B3 0.174045248211037 0.865717934161724 0.0774698114814614 0.879535738661148 miRNAWalker2_validate -0.231672958486033 2.5496446020765e-05 NA NA NA hsa-miR-107 PAK3 -0.289737369453023 0.769655185893943 0.920809798971622 0.118751874817418 miRanda -0.335381463607498 0.0426204334130676 NA NA NA hsa-miR-17-5p PAK3 -0.643066792834501 0.320674049526638 0.920809798971622 0.118751874817418 TargetScan -0.266518262937127 0.0332583243944903 NA NA NA hsa-miR-18a-3p PAK3 -0.188202012159778 0.618004963641688 0.920809798971622 0.118751874817418 MirTarget;miRNATAP -0.417855709420255 0.00246194094394092 NA NA NA hsa-miR-200c-5p PAK3 -0.385629981568361 0.472280307737369 0.920809798971622 0.118751874817418 MirTarget;miRNATAP -0.284905585129603 0.00853990498224934 NA NA NA hsa-miR-330-5p PAK3 -0.152605584680815 0.787259112745893 0.920809798971622 0.118751874817418 miRanda -0.36000606412481 0.0128174252960069 NA NA NA hsa-miR-362-5p PAK3 -0.35564884735017 0.452162806620853 0.920809798971622 0.118751874817418 TargetScan -0.387756163572529 6.07569555146626e-05 NA NA NA hsa-miR-550a-3p PAK3 -0.119986184945279 0.712964993845202 0.920809798971622 0.118751874817418 MirTarget;miRNATAP -0.359286905726319 0.00436734419303113 NA NA NA hsa-miR-150-5p PALM2 -0.00683324482969283 0.994067057151257 0.124267555548599 0.719368375482953 mirMAP -0.12278863385031 0.00551555887835894 NA NA NA hsa-miR-15b-5p PAM 0.251826642099145 0.790709218602499 0.162646958592559 0.80464908790382 miRNATAP -0.326289669887208 1.25014206890719e-05 NA NA NA hsa-miR-214-3p PAN2 0.0312810611346688 0.952640488671912 0.0511795211585202 0.916933529374309 MirTarget -0.138309135307188 4.37919975088873e-07 NA NA NA hsa-miR-222-3p PAN2 -0.233673471709747 0.726651775432807 0.0511795211585202 0.916933529374309 miRNAWalker2_validate -0.13554665231259 0.000726618441974622 NA NA NA hsa-miR-27a-3p PANK1 0.309634509674364 0.703724209648479 -0.0264254428661714 0.945467353578941 miRNATAP -0.180526812338273 0.000432849181994639 NA NA NA hsa-miR-98-5p PAPPA -0.0484028619275874 0.910781316485549 0.470558902758993 0.30496033799475 MirTarget -0.181812904675671 0.0442198279248903 NA NA NA hsa-miR-150-5p PAQR5 -0.00683324482969283 0.994067057151257 -0.388043716682013 0.258658497017939 mirMAP -0.194202445048863 4.11618607888662e-06 NA NA NA hsa-miR-28-5p PART1 -0.0511712157419266 0.910958192291954 0.456301514097373 0.394268007523409 miRanda -0.525700409596362 0.000832013724770627 NA NA NA hsa-miR-139-5p PATZ1 -0.0625698939687087 0.914810329989088 -0.329534851576771 0.582580486918757 miRanda -0.14229063767326 3.27401776429628e-05 NA NA NA hsa-let-7a-5p PAX2 0.0514604984725615 0.971564723582327 0.82416501917504 0.434623371335361 TargetScan;mirMAP -0.716412856174486 0.0281731483001041 NA NA NA hsa-let-7d-5p PAX2 0.0119393569456978 0.988390093874148 0.82416501917504 0.434623371335361 mirMAP -1.24094302784515 2.40121425974918e-05 NA NA NA hsa-let-7f-5p PAX2 -0.399676495198673 0.695365879077383 0.82416501917504 0.434623371335361 mirMAP -0.538706696790245 0.00948885817353825 NA NA NA hsa-let-7g-5p PAX2 -0.320647530232065 0.660364346555039 0.82416501917504 0.434623371335361 mirMAP -0.66949033691136 0.015445290657274 NA NA NA hsa-let-7i-5p PAX2 -0.0940710536612883 0.902310710205355 0.82416501917504 0.434623371335361 mirMAP -0.718136194400375 0.0122092700602649 NA NA NA hsa-miR-23b-5p PAX2 0.0737278893675128 0.828031282876682 0.82416501917504 0.434623371335361 miRNATAP -0.750373380498099 0.000811627002593919 NA NA NA hsa-miR-28-5p PAX2 -0.0511712157419266 0.910958192291954 0.82416501917504 0.434623371335361 mirMAP -0.970069797616299 0.00298214676854289 NA NA NA hsa-miR-362-5p PAX2 -0.35564884735017 0.452162806620853 0.82416501917504 0.434623371335361 PITA;mirMAP -0.531320280803809 0.00464410082913922 NA NA NA hsa-miR-625-5p PAX2 -0.725005787172203 0.0605502864822602 0.82416501917504 0.434623371335361 mirMAP -0.444570959505797 0.0142025016549071 NA NA NA hsa-miR-22-3p PBX1 0.0468440219945929 0.967778504781139 0.164340803932783 0.807580076898079 MirTarget -0.194138411567884 2.28566196281606e-08 NA NA NA hsa-miR-98-5p PBX1 -0.0484028619275874 0.910781316485549 0.164340803932783 0.807580076898079 MirTarget -0.105121723314857 0.000552437820850218 NA NA NA hsa-miR-222-3p PBX2 -0.233673471709747 0.726651775432807 -0.162246585230382 0.793655328714028 miRNAWalker2_validate -0.119122726865663 0.00187876802067484 NA NA NA hsa-miR-363-3p PCDH11X -0.186046567396088 0.728622856049059 -0.146326856854071 0.838908950520701 MirTarget;miRNATAP -0.178347648172711 0.0479559340464927 NA NA NA hsa-miR-141-3p PCDH17 -0.36932301319088 0.428364456128406 0.0521235924877654 0.87884490056068 miRNATAP -0.24106076135741 9.59169514957248e-05 NA NA NA hsa-miR-16-5p PCDH17 -0.199225750365017 0.742834324195084 0.0521235924877654 0.87884490056068 MirTarget;miRNATAP -0.147048896469923 0.0264748011276126 NA NA NA hsa-miR-200a-3p PCDH17 -0.801422367541981 0.147987649395985 0.0521235924877654 0.87884490056068 miRNATAP -0.113599034880888 0.0208506212046467 NA NA NA hsa-miR-200c-5p PCDH17 -0.385629981568361 0.472280307737369 0.0521235924877654 0.87884490056068 MirTarget;miRNATAP -0.141416025159373 0.00538535260075935 NA NA NA hsa-miR-29a-3p PCDH17 0.203872357562561 0.859946061784007 0.0521235924877654 0.87884490056068 MirTarget;miRNATAP -0.192828470525691 0.00202104086400782 NA NA NA hsa-miR-29b-1-5p PCDH17 -0.188524660858621 0.603438322810761 0.0521235924877654 0.87884490056068 mirMAP -0.216637781370099 0.00014760534920096 NA NA NA hsa-miR-29b-3p PCDH17 -0.249746665931503 0.558208927436524 0.0521235924877654 0.87884490056068 MirTarget;miRNATAP -0.131683394574369 0.00289930222546877 NA NA NA hsa-miR-29c-3p PCDH17 0.042533372292219 0.941334605544826 0.0521235924877654 0.87884490056068 MirTarget;miRNATAP -0.101744083914263 0.0465425693450781 NA NA NA hsa-miR-30c-5p PCDH17 -0.183013966936985 0.833177718550926 0.0521235924877654 0.87884490056068 MirTarget;miRNATAP -0.220037393296409 0.004089166365128 NA NA NA hsa-miR-30e-3p PCDH17 0.202355073367528 0.857417040078429 0.0521235924877654 0.87884490056068 MirTarget -0.353863147638841 1.70032019997433e-05 NA NA NA hsa-miR-30e-5p PCDH17 -0.00273037859886571 0.997115479601006 0.0521235924877654 0.87884490056068 MirTarget -0.321317273171416 1.27651131436222e-05 NA NA NA hsa-miR-497-5p PCDH17 -0.345178187351251 0.463288640782623 0.0521235924877654 0.87884490056068 MirTarget;miRNATAP -0.110407875725515 0.0376926087840841 NA NA NA hsa-miR-107 PCDH9 -0.289737369453023 0.769655185893943 0.194387059486137 0.725495299759085 miRanda -0.345983984696159 0.0341103443392472 NA NA NA hsa-miR-660-5p PCDH9 -0.561687438133488 0.138270972367544 0.194387059486137 0.725495299759085 MirTarget;miRNATAP -0.26870633200103 0.0084675724916667 NA NA NA hsa-miR-15b-5p PCDHA2 0.251826642099145 0.790709218602499 -0.268926547259511 0.598017657087117 MirTarget -0.457622394902518 0.0030586041281686 NA NA NA hsa-miR-221-3p PCDHA2 -0.261179092929062 0.744019631321393 -0.268926547259511 0.598017657087117 MirTarget -0.261523550077618 0.0263532042131098 NA NA NA hsa-miR-222-3p PCDHA2 -0.233673471709747 0.726651775432807 -0.268926547259511 0.598017657087117 MirTarget -0.236886649858966 0.0427440987825123 NA NA NA hsa-miR-15b-5p PCDHA9 0.251826642099145 0.790709218602499 -0.530108257843928 0.379969416014821 MirTarget -0.394065694838313 0.0185648373090242 NA NA NA hsa-miR-107 PCDHGA2 -0.289737369453023 0.769655185893943 0.323921164955682 0.506956459213935 miRanda -0.330190354403211 0.0229980867299139 NA NA NA hsa-miR-107 PCDHGA3 -0.289737369453023 0.769655185893943 -0.109025365539175 0.80287253027672 miRanda -0.302149967622284 0.0192903157009837 NA NA NA hsa-miR-107 PCDHGA4 -0.289737369453023 0.769655185893943 0.335452466790047 0.43685699738015 miRanda -0.354544601126114 0.00545982862754483 NA NA NA hsa-miR-107 PCDHGA5 -0.289737369453023 0.769655185893943 0.472956070159331 0.187314575566294 miRanda -0.307758613087157 0.00363100211905924 NA NA NA hsa-miR-107 PCDHGA6 -0.289737369453023 0.769655185893943 0.0698468874774425 0.843963880667343 miRanda -0.242723341780078 0.0191868581543271 NA NA NA hsa-miR-107 PCDHGA8 -0.289737369453023 0.769655185893943 0.312277651176653 0.486516447666532 miRanda -0.355158827207968 0.00761689569722247 NA NA NA hsa-miR-107 PCDHGA9 -0.289737369453023 0.769655185893943 0.531228523896566 0.248557364492554 miRanda -0.308263402248704 0.0182243870114373 NA NA NA hsa-miR-107 PCDHGB2 -0.289737369453023 0.769655185893943 0.744666497529231 0.103660360344809 miRanda -0.388708554468725 0.00307772018564009 NA NA NA hsa-miR-107 PCDHGB4 -0.289737369453023 0.769655185893943 -0.556666832974654 0.306692126583208 miRanda -0.314627261494649 0.0456336319461438 NA NA NA hsa-miR-107 PCDHGC3 -0.289737369453023 0.769655185893943 0.336485891720545 0.566989158558655 miRanda -0.210912507937492 0.000624724124714964 NA NA NA hsa-miR-24-3p PCNA 0.0408517902063537 0.966828370841971 -0.0408586662993748 0.946059561187999 miRNAWalker2_validate -0.137795701421617 0.00720304918663369 NA NA NA hsa-miR-26b-5p PCNA 0.16143906971203 0.790777916193478 -0.0408586662993748 0.946059561187999 miRNAWalker2_validate -0.179845674250248 0.00128171791189689 NA NA NA hsa-miR-26b-5p PDCD10 0.16143906971203 0.790777916193478 0.132251375285142 0.802625015019519 miRNATAP -0.125308863374091 0.0153791989423282 NA NA NA hsa-miR-30e-5p PDCD10 -0.00273037859886571 0.997115479601006 0.132251375285142 0.802625015019519 miRNATAP -0.206623064073383 4.11246174439358e-06 NA NA NA hsa-miR-15b-5p PDCD4 0.251826642099145 0.790709218602499 0.392198104823223 0.507729728599335 MirTarget;miRNATAP -0.10682597644055 0.036110839368774 NA NA NA hsa-miR-197-3p PDDC1 0.0240027695773914 0.981971058073739 -0.0245974548043471 0.960818976848474 mirMAP -0.24618791043236 8.05107925981514e-08 NA NA NA hsa-miR-107 PDE3B -0.289737369453023 0.769655185893943 -0.41914702311429 0.250716934813876 MirTarget;PITA;miRanda;miRNATAP -0.224336172980914 0.0364552741880176 NA NA NA hsa-miR-128-3p PDE3B -0.0364518492233463 0.95841670253784 -0.41914702311429 0.250716934813876 miRNAWalker2_validate -0.284574541309113 0.0107644571224093 NA NA NA hsa-miR-140-3p PDE6B -0.105651799466207 0.9077781740714 0.375089719552633 0.359696794665873 MirTarget -0.262594547548206 0.00039448780210685 NA NA NA hsa-miR-27a-3p PDE7B 0.309634509674364 0.703724209648479 -0.105448272716949 0.720596351502969 miRNATAP -0.199732643139026 0.00182103126767746 NA NA NA hsa-miR-150-3p PDE8B -0.419098198991827 0.371449470483153 -0.230216033733265 0.508707091873851 MirTarget;miRNATAP -0.165359472003801 0.000708549059912627 NA NA NA hsa-miR-27a-3p PDE8B 0.309634509674364 0.703724209648479 -0.230216033733265 0.508707091873851 MirTarget -0.245080204171327 0.00626414316303196 NA NA NA hsa-miR-27b-3p PDE8B 0.306246927737414 0.735781270461428 -0.230216033733265 0.508707091873851 MirTarget -0.242572532532809 0.011575202410254 NA NA NA hsa-miR-129-5p PDGFRL 0.417083435812871 0.454236109516901 0.977516245489034 0.0253802748343697 miRanda -0.201399181002133 4.36458734577176e-06 NA NA NA hsa-miR-25-3p PDGFRL 0.0681841609869576 0.955267320175687 0.977516245489034 0.0253802748343697 miRNAWalker2_validate -0.265834915225836 0.00572782938588627 NA NA NA hsa-miR-103a-3p PDK4 -0.360357769638318 0.770748924684999 0.690479188061747 0.129784523042214 miRNAWalker2_validate;MirTarget -0.145145699126225 0.0279318334205669 NA NA NA hsa-miR-107 PDK4 -0.289737369453023 0.769655185893943 0.690479188061747 0.129784523042214 MirTarget;miRanda;miRNATAP -0.192353364941391 0.0118123523027111 NA NA NA hsa-miR-15a-5p PDK4 -0.288312177100971 0.506274963146038 0.690479188061747 0.129784523042214 MirTarget;miRNATAP -0.18935384696524 0.000297689910860775 NA NA NA hsa-miR-15b-5p PDK4 0.251826642099145 0.790709218602499 0.690479188061747 0.129784523042214 MirTarget;miRNATAP -0.261743081765223 0.000886923227211238 NA NA NA hsa-miR-16-5p PDK4 -0.199225750365017 0.742834324195084 0.690479188061747 0.129784523042214 miRNAWalker2_validate;MirTarget;miRNATAP -0.212497387893709 0.00107841844760042 NA NA NA hsa-miR-429 PDK4 -0.596617415946644 0.128967410286089 0.690479188061747 0.129784523042214 miRanda -0.120041270760068 0.0153411025498055 NA NA NA hsa-miR-942-5p PDK4 -0.766562590119066 0.0293037013994827 0.690479188061747 0.129784523042214 MirTarget -0.207390647516432 0.000148092464981069 NA NA NA hsa-miR-15b-5p PDPR 0.251826642099145 0.790709218602499 0.13717349127163 0.793213531362537 miRNATAP -0.152073381723029 0.0119862526786896 NA NA NA hsa-miR-214-3p PDRG1 0.0312810611346688 0.952640488671912 0.250713350071338 0.563737089772658 MirTarget -0.105029389685667 4.49953934460816e-06 25706919 MicroRNA 214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer; Dual-luciferase reporter assay recognized PDRG1 as direct downstream target gene of miR-214; PDRG1 was significantly increased in tumors low of miR-214 and knockdown of PDRG1 mimicked the effects of miR-214 overexpression; Our findings manifest that miR-214 could exert tumor-suppressive effects in bladder cancer by directly down-regulating oncogene PDRG1 and suggest an appealing novel indicator for prognostic and therapeutic intervention of bladder cancer worse prognosis bladder cancer hsa-miR-107 PDS5B -0.289737369453023 0.769655185893943 -0.0631705270907341 0.886982264368488 miRanda -0.127585807766948 0.000327953768110736 NA NA NA hsa-miR-30c-5p PDSS1 -0.183013966936985 0.833177718550926 0.0206095214964055 0.944093573431748 miRNATAP -0.133356894122502 0.00189686948367024 NA NA NA hsa-miR-150-5p PEG10 -0.00683324482969283 0.994067057151257 0.00912550920660937 0.989899679885026 miRNATAP -0.190919832327342 0.00160227621262904 NA NA NA hsa-miR-221-3p PEG10 -0.261179092929062 0.744019631321393 0.00912550920660937 0.989899679885026 miRNAWalker2_validate -0.199199056700491 0.0474630333657355 NA NA NA hsa-miR-15b-5p PEX12 0.251826642099145 0.790709218602499 0.229539682519236 0.421252365014421 MirTarget -0.1688485320692 1.69422482035221e-05 NA NA NA hsa-miR-221-3p PEX19 -0.261179092929062 0.744019631321393 0.177233126323997 0.77412023543468 miRNAWalker2_validate -0.176392489378683 7.39749552158275e-11 NA NA NA hsa-miR-15b-5p PEX5 0.251826642099145 0.790709218602499 -0.0541579382911079 0.912996954225504 MirTarget;miRNATAP -0.146634812835041 0.000615040019278257 NA NA NA hsa-miR-22-3p PEX5 0.0468440219945929 0.967778504781139 -0.0541579382911079 0.912996954225504 miRNAWalker2_validate -0.143455706822147 5.33700341873953e-06 NA NA NA hsa-miR-214-3p PFKFB4 0.0312810611346688 0.952640488671912 -0.515334899367728 0.196408330550881 MirTarget -0.10273071324768 0.00403203895686564 NA NA NA hsa-miR-27a-3p PFKM 0.309634509674364 0.703724209648479 0.246269933062444 0.63558351149718 MirTarget -0.105130399121787 0.0233675137059517 NA NA NA hsa-miR-150-5p PFN2 -0.00683324482969283 0.994067057151257 0.349973628350141 0.597835513378729 miRNATAP -0.120545638662601 7.71590575059167e-05 NA NA NA hsa-miR-27a-3p PGAP1 0.309634509674364 0.703724209648479 -0.0321372382018619 0.932607001535326 miRNATAP -0.107242755564486 0.0360340676736692 NA NA NA hsa-miR-130b-3p PGR -0.246958204594817 0.524070870130445 0.807256079502211 0.19558472400394 mirMAP -0.313728630224893 0.0353240130203602 NA NA NA hsa-miR-155-5p PGR -0.320577372003167 0.673183036961734 0.807256079502211 0.19558472400394 mirMAP -0.31655436322561 0.00580296057399008 20388420;19454029;23162645 It's indicated that the up-regulation of miR-155 expression was associated with advanced TNM clinical stage median 0.316 0.358 and 0.417 respectively for stage I II and III tumor P = 0.002 lymph node metastasis median 0.383 and 0.355 respectively for cases with positive and negative lymph nodes P = 0.034 higher proliferation index median 0.387 and 0.353 respectively for cases with high proliferation index Ki67 > 10% and low proliferation index Ki67 ≤ 10% P = 0.019 estrogen receptor-positive 0.367 and 0.318 respectively for cases with positive estrogen receptor and negative group P = 0.041 and progesterone receptor-positive 0.398 and 0.335 respectively for cases with positive progesterone receptor and negative group P = 0.029 in patients with breast cancer; The expression of miR-155 is up-regulated in primary breast cancer especially in patients with positive estrogen and progesterone receptor;While the expression of all three miRNAs was similar in samples from healthy women compared to those with breast cancer women with progesterone receptor PR p = 0.016 positive tumors had higher miR-155 expression than tumors that were negative for these receptors;miR 155 and miR 31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status; The expression levels of miR-155 but not miR-31 were inversely correlated with estrogen receptor ER and progesterone receptor PR expression ER r=-0.353 P=0.003; PR r=-0.357 P=0.003 staging;metastasis;; breast cancer;breast cancer;breast cancer hsa-miR-452-5p PGR -0.598209167153363 0.262476098043185 0.807256079502211 0.19558472400394 mirMAP -0.263957671457457 0.00126313639224269 NA NA NA hsa-miR-342-3p PHACTR4 -0.233020179388453 0.739959578456401 -0.0173954075510121 0.977581160781889 miRanda -0.140028726767166 0.000582766550989017 NA NA NA hsa-miR-22-3p PHC1 0.0468440219945929 0.967778504781139 -0.279352782259429 0.570528372205872 MirTarget -0.169895225365525 8.61064829626614e-05 NA NA NA hsa-miR-324-5p PHF11 -0.358991607952497 0.499732551112182 0.194250134737076 0.654795519642253 miRanda -0.133284395707983 0.00080513179314816 NA NA NA hsa-miR-140-3p PHF20L1 -0.105651799466207 0.9077781740714 -0.198521380754143 0.714598913563395 PITA -0.156874531167909 3.68573914645511e-05 NA NA NA hsa-miR-15b-5p PHF21A 0.251826642099145 0.790709218602499 -0.0229500388054138 0.96355078492832 MirTarget -0.109204609123077 0.00350142713071582 NA NA NA hsa-miR-140-3p PHKG2 -0.105651799466207 0.9077781740714 -0.0340232743320463 0.942538253607459 mirMAP -0.110951019933647 0.000326895948387251 NA NA NA hsa-miR-107 PHLDA1 -0.289737369453023 0.769655185893943 -0.0127555088841484 0.980150421236681 miRanda -0.181916902725066 0.0365359948276559 NA NA NA hsa-miR-20a-5p PHYH -0.857283498361138 0.070259604943771 -0.170700252770478 0.704526439578081 miRNAWalker2_validate -0.133829446277862 0.000343911739005083 NA NA NA hsa-miR-361-5p PHYH -0.278147578656315 0.728553069590798 -0.170700252770478 0.704526439578081 miRanda -0.216991052407285 0.0066861621116755 NA NA NA hsa-miR-107 PID1 -0.289737369453023 0.769655185893943 0.168850395556573 0.642927603664984 PITA;miRanda -0.415999216356014 3.96778719091263e-05 NA NA NA hsa-miR-146b-5p PID1 0.0340352805627226 0.964565988329585 0.168850395556573 0.642927603664984 miRanda -0.260163319056731 9.71053348360112e-05 NA NA NA hsa-miR-15a-5p PID1 -0.288312177100971 0.506274963146038 0.168850395556573 0.642927603664984 MirTarget;miRNATAP -0.170942165089214 0.0152175086907524 NA NA NA hsa-miR-15b-5p PID1 0.251826642099145 0.790709218602499 0.168850395556573 0.642927603664984 MirTarget;miRNATAP -0.33815117690069 0.00132864992620296 NA NA NA hsa-miR-16-5p PID1 -0.199225750365017 0.742834324195084 0.168850395556573 0.642927603664984 MirTarget;miRNATAP -0.456372056240115 9.74427986124534e-08 NA NA NA hsa-miR-186-5p PID1 -0.246324984406451 0.701310703524093 0.168850395556573 0.642927603664984 MirTarget;miRNATAP -0.370569111220152 0.000565535246890361 NA NA NA hsa-miR-324-5p PID1 -0.358991607952497 0.499732551112182 0.168850395556573 0.642927603664984 miRanda -0.321761271630728 0.000332161445521387 NA NA NA hsa-miR-335-3p PID1 0.0738544228922926 0.89349398283313 0.168850395556573 0.642927603664984 mirMAP -0.155930844138495 0.0157433642331679 NA NA NA hsa-miR-17-5p PIK3R1 -0.643066792834501 0.320674049526638 0.179845155170782 0.739191606793684 MirTarget;TargetScan;miRNATAP -0.107791032137778 0.0218809791963541 NA NA NA hsa-miR-221-3p PIK3R1 -0.261179092929062 0.744019631321393 0.179845155170782 0.739191606793684 MirTarget -0.207116873312359 1.78107159906552e-05 NA NA NA hsa-miR-222-3p PIK3R1 -0.233673471709747 0.726651775432807 0.179845155170782 0.739191606793684 MirTarget -0.210819526678877 1.05428412163985e-05 NA NA NA hsa-miR-629-3p PIK3R1 -0.455149050361454 0.209212127982437 0.179845155170782 0.739191606793684 MirTarget -0.183499975721091 7.36573431720359e-05 NA NA NA hsa-miR-27a-3p PIP5K1B 0.309634509674364 0.703724209648479 0.0109415508244106 0.981356867204169 MirTarget -0.389564587096439 0.00132834383980279 NA NA NA hsa-miR-185-5p PITPNC1 -0.646398728237327 0.117918763555657 0.216876156978987 0.606258399272463 miRNATAP -0.205684203540155 0.00089073671655614 NA NA NA hsa-miR-21-5p PITPNC1 -0.515762857245393 0.64198914412298 0.216876156978987 0.606258399272463 mirMAP -0.146027966115943 0.00127770082886666 NA NA NA hsa-miR-23b-3p PITPNC1 0.188949711826471 0.848360545615343 0.216876156978987 0.606258399272463 MirTarget -0.187206844147885 0.00849654736699989 NA NA NA hsa-miR-34a-5p PITPNC1 -0.689845719362998 0.195745632660671 0.216876156978987 0.606258399272463 MirTarget;miRNATAP -0.206265220924268 0.000363665073073276 NA NA NA hsa-miR-664a-3p PITPNC1 -0.139841943049965 0.800834383581795 0.216876156978987 0.606258399272463 mirMAP -0.164730780315875 0.0207072148267119 NA NA NA hsa-miR-15b-5p PITPNM2 0.251826642099145 0.790709218602499 -0.350595535487645 0.389324347985011 mirMAP -0.151608445959439 0.0311652654122546 NA NA NA hsa-miR-148a-3p PITPNM3 -0.324144803192141 0.746264759480212 -0.129159774944464 0.787380294427841 mirMAP -0.187297362028089 0.00115834547568604 NA NA NA hsa-miR-107 PKD1 -0.289737369453023 0.769655185893943 -0.281338158145099 0.622976438898343 miRanda -0.128205193462833 0.0290273627156004 NA NA NA hsa-miR-194-5p PKD2 -0.141051051043955 0.809072276924359 0.0828022710230565 0.84774680321079 miRNATAP -0.104333254170083 0.000433995963222943 NA NA NA hsa-miR-93-5p PKD2 -0.375078982324499 0.732311284477601 0.0828022710230565 0.84774680321079 miRNAWalker2_validate;MirTarget;miRNATAP -0.135971556715793 0.000866437445353256 NA NA NA hsa-miR-107 PKIA -0.289737369453023 0.769655185893943 0.246210914878229 0.603765376989981 miRanda -0.349462493676544 0.0123509280322462 NA NA NA hsa-miR-27a-3p PKIA 0.309634509674364 0.703724209648479 0.246210914878229 0.603765376989981 MirTarget;miRNATAP -0.404752542570459 0.00085099485098208 NA NA NA hsa-miR-27a-3p PKNOX2 0.309634509674364 0.703724209648479 0.436501614750127 0.326720934754083 miRNATAP -0.248979003594665 0.0111263650271573 NA NA NA hsa-miR-222-3p PKP2 -0.233673471709747 0.726651775432807 -0.288605734803742 0.621683168509543 miRNAWalker2_validate -0.154363358117797 0.00280957094170363 NA NA NA hsa-miR-485-3p PLA2G4A 0.260493747772693 0.658365017969425 0.394740794587628 0.353757909855311 MirTarget -0.156076910071963 0.00242688407627589 NA NA NA hsa-miR-128-3p PLA2G5 -0.0364518492233463 0.95841670253784 0.180702296489151 0.636334791264485 miRNAWalker2_validate -0.402077608202707 0.000489651577825212 NA NA NA hsa-miR-15b-5p PLAG1 0.251826642099145 0.790709218602499 0.206633268792798 0.690698367591079 MirTarget;miRNATAP -0.319399869912002 0.0092108745298099 NA NA NA hsa-miR-98-5p PLAGL1 -0.0484028619275874 0.910781316485549 -0.480710625682777 0.313396838240501 miRNAWalker2_validate -0.157785521787401 0.0215576928352192 NA NA NA hsa-miR-22-3p PLAGL2 0.0468440219945929 0.967778504781139 -0.0546141513819354 0.929591181369687 miRNATAP -0.123141158737007 0.00339634039869923 NA NA NA hsa-miR-181c-5p PLAU -0.262596734125804 0.645471285705202 0.581956287469663 0.353086487135283 MirTarget -0.260132490767772 0.00101322634434307 NA NA NA hsa-miR-181d-5p PLAU -0.294264170071504 0.604392929232074 0.581956287469663 0.353086487135283 MirTarget -0.146797101733368 0.0357180304591007 NA NA NA hsa-let-7b-3p PLCB4 0.314328399485033 0.684245834514538 -0.104487883926798 0.807394366627039 mirMAP;miRNATAP -0.187446855862038 0.0340843491622398 NA NA NA hsa-let-7f-1-3p PLCB4 0.131753980154284 0.686438107181988 -0.104487883926798 0.807394366627039 mirMAP -0.228311116246995 0.00229391372260333 NA NA NA hsa-let-7g-5p PLCB4 -0.320647530232065 0.660364346555039 -0.104487883926798 0.807394366627039 miRNATAP -0.183098730071971 0.0368296227276714 NA NA NA hsa-let-7i-5p PLCB4 -0.0940710536612883 0.902310710205355 -0.104487883926798 0.807394366627039 miRNATAP -0.288647558718207 0.00142394047128034 NA NA NA hsa-miR-26b-5p PLCB4 0.16143906971203 0.790777916193478 -0.104487883926798 0.807394366627039 miRNAWalker2_validate -0.234978820447685 0.0332086513056987 NA NA NA hsa-miR-30d-5p PLCB4 -0.127037899273548 0.917197761243139 -0.104487883926798 0.807394366627039 miRNATAP -0.318124992438013 0.000983721654986086 NA NA NA hsa-miR-361-5p PLCB4 -0.278147578656315 0.728553069590798 -0.104487883926798 0.807394366627039 miRanda -0.291273433365226 0.0264838763368607 NA NA NA hsa-miR-181c-5p PLCL2 -0.262596734125804 0.645471285705202 -0.0537135853230506 0.866822933875345 miRNATAP -0.113330667077067 0.0161686984329703 NA NA NA hsa-miR-22-3p PLCXD3 0.0468440219945929 0.967778504781139 -0.58817649532739 0.365923835413038 miRNATAP -0.441334849824991 0.00309393608330694 NA NA NA hsa-miR-15b-5p PLEKHA5 0.251826642099145 0.790709218602499 -0.0782443041146728 0.8582377270912 MirTarget -0.11547705182825 0.0367993711779671 NA NA NA hsa-miR-218-5p PLEKHF2 -0.142331684313268 0.733683746687823 0.240491165893117 0.64375331961319 MirTarget -0.150971716528686 8.13149591485356e-06 NA NA NA hsa-miR-22-3p PLEKHG4B 0.0468440219945929 0.967778504781139 -0.659296318691375 0.213793905576961 mirMAP -0.296512723893384 0.000168033363815604 NA NA NA hsa-miR-139-5p PLEKHG6 -0.0625698939687087 0.914810329989088 -0.79093313477156 0.0541145097186795 miRanda -0.198744131164268 0.00764747422047713 NA NA NA hsa-miR-27a-3p PLEKHH2 0.309634509674364 0.703724209648479 -0.139106696356358 0.72648813371358 miRNATAP -0.177723503644473 0.0300264563785027 NA NA NA hsa-miR-27a-3p PLEKHJ1 0.309634509674364 0.703724209648479 0.110026992809783 0.800301002408192 miRNATAP -0.210973077778512 2.93178625139125e-09 NA NA NA hsa-miR-15b-5p PLEKHM3 0.251826642099145 0.790709218602499 -0.0736834045318551 0.851144302277632 MirTarget -0.168832944076564 0.000319779535329022 NA NA NA hsa-let-7b-5p PLK1 0.396604576702067 0.783406687058469 -0.319642391345589 0.552578198149986 miRNAWalker2_validate -0.190163026185373 0.000171731575559793 NA NA NA hsa-miR-100-5p PLK1 0.0542447471759004 0.961097766133859 -0.319642391345589 0.552578198149986 miRNAWalker2_validate;miRTarBase -0.143015784501886 0.000375241308161879 22246341;23151088;23842624;25537513;22120675;21636267 Together these results suggest that low miR-100 expression may be an independent poor prognostic factor and miR-100 can function as a tumor suppressor by targeting PLK1 in human EOCs;MicroRNA 100 is a potential molecular marker of non small cell lung cancer and functions as a tumor suppressor by targeting polo like kinase 1; By using microRNA miR target prediction algorithms we identified miR-100 that might potentially bind the 3'-untranslated region of PLK1 transcripts; The purpose of this study was to investigate the roles of miR-100 and its association with PLK1 in NSCLC development; Finally the effects of miR-100 expression on growth apoptosis and cell cycle of NSCLC cells by posttranscriptionally regulating PLK1 expression were determined; Meanwhile miR-100 mimics could significantly inhibit PLK1 mRNA and protein expression and reduce the luciferase activity of a PLK1 3' untranslated region-based reporter construct in A549 cells; Furthermore small interfering RNA siRNA-mediated PLK1 downregulation could mimic the effects of miR-100 mimics while PLK1 overexpression could partially rescue the phenotypical changes of NSCLC cells induced by miR-100 mimics; Our findings indicate that low miR-100 may be a poor prognostic factor for NSCLC patients and functions as a tumor suppressor by posttranscriptionally regulating PLK1 expression;In HCC tissues miR-100 expression was inversely correlated with the expression of plk1 protein r = -0.418; P = 0.029; Therefore downregulation of miR-100 was correlated with progressive pathological feature and poor prognosis in HCC patients and miR-100 could function as a tumor suppressor by targeting plk1;Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 Plk1 down-regulation;MiR 100 resensitizes docetaxel resistant human lung adenocarcinoma cells SPC A1 to docetaxel by targeting Plk1; Knock-down of Plk1 which was a direct target of miR-100 yielded similar effects as that of ectopic miR-100 expression; The inverse correlation between miR-100 and Plk1 expression was also detected in nude mice SPC-A1/DTX tumor xenografts and clinical lung adenocarcinoma tissues and was proved to be related with the in vivo response to docetaxel; Thus our results suggested that down-regulation of miR-100 could lead to Plk1 over-expression and eventually to docetaxel chemoresistance of human lung adenocarcinoma;Reduced miR 100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein; Through modulating miR-100 expression using miR-100 inhibitor or mimic in vitro cell growth cycle and apoptosis were tested separately by MTT or flow cytometry and meanwhile Polo-like kinase1 PLK1 mRNA and protein expressions were detected by qRT-PCR and immunoblotting; The expression of PLK1 in 125 cervical tissues was also examined by immunohistochemical staining and the correlation between miR-100 and PLK1 expression in the same tissues was analysed; The modulation of miR-100 expression remarkably influenced cell proliferation cycle and apoptosis as well as the level of PLK1 protein but not mRNA in vitro experiments; PLK1 expression was negatively correlated with miR-100 expression in CIN3 and cervical cancer tissues; The reduced miR-100 expression participates in the development of cervical cancer at least partly through loss of inhibition to target gene PLK1 which probably occurs in a relative late phase of carcinogenesis ;;progression;worse prognosis;;drug resistance;tumorigenesis ovarian cancer;lung squamous cell cancer;liver cancer;breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-128-3p PLK2 -0.0364518492233463 0.95841670253784 0.263197612448985 0.615226064996544 MirTarget -0.217270538549621 0.0148618805400975 NA NA NA hsa-miR-940 PLLP 0.19340062942074 0.679749292292113 0.571207135023926 0.270385782325565 miRNATAP -0.169293531539981 0.00172637761501254 NA NA NA hsa-miR-129-5p PLN 0.417083435812871 0.454236109516901 0.928704477893138 0.0928745208233161 miRanda -0.320888130650862 0.000156995617549436 NA NA NA hsa-miR-221-3p PLOD2 -0.261179092929062 0.744019631321393 0.0941798242480054 0.874138877907245 miRNAWalker2_validate -0.11666792763322 0.0453114307095464 NA NA NA hsa-miR-26a-5p PLOD2 0.0483232931294246 0.955218190818435 0.0941798242480054 0.874138877907245 MirTarget;miRNATAP -0.187252009073664 0.0214136109187063 26983694;27310702 Thus our data showed that two genes promoting metastasis LOXL2 and PLOD2 were epigenetically regulated by tumor-suppressive microRNAs miR-26a and miR-26b providing important insights into the molecular mechanisms of RCC metastasis;The gene encoding procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 PLOD2 a collagen crosslinking enzyme was directly regulated by miR-26a-5p and miR-26b-5p; PLOD2 which is associated with the stiffness of the extracellular matrix was directly regulated by miR-26a-5p and miR-26b-5p and may be a good prognostic marker in patients with BC metastasis; kidney renal cell cancer;bladder cancer hsa-miR-26b-5p PLOD2 0.16143906971203 0.790777916193478 0.0941798242480054 0.874138877907245 miRNAWalker2_validate;MirTarget;miRNATAP -0.181242325533454 0.0251417706723861 26983694;27310702 Thus our data showed that two genes promoting metastasis LOXL2 and PLOD2 were epigenetically regulated by tumor-suppressive microRNAs miR-26a and miR-26b providing important insights into the molecular mechanisms of RCC metastasis;Tumour suppressive miRNA 26a 5p and miR 26b 5p inhibit cell aggressiveness by regulating PLOD2 in bladder cancer; The gene encoding procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 PLOD2 a collagen crosslinking enzyme was directly regulated by miR-26a-5p and miR-26b-5p; PLOD2 which is associated with the stiffness of the extracellular matrix was directly regulated by miR-26a-5p and miR-26b-5p and may be a good prognostic marker in patients with BC metastasis; kidney renal cell cancer;bladder cancer hsa-miR-106a-5p PLSCR4 -0.820057689616516 0.0254490146664247 0.42936200071232 0.370488039339793 MirTarget -0.186495792421886 7.0018535122512e-05 NA NA NA hsa-miR-17-5p PLSCR4 -0.643066792834501 0.320674049526638 0.42936200071232 0.370488039339793 MirTarget;TargetScan -0.143744748534709 0.0146368750325602 NA NA NA hsa-miR-455-3p PLSCR4 0.112667549349787 0.88195515618473 0.42936200071232 0.370488039339793 miRNATAP -0.132790356845255 0.0242645734618287 NA NA NA hsa-miR-93-5p PLSCR4 -0.375078982324499 0.732311284477601 0.42936200071232 0.370488039339793 MirTarget -0.246425452088235 0.000371877019091803 NA NA NA hsa-miR-15b-5p PLXNA2 0.251826642099145 0.790709218602499 -0.165972689963265 0.757637121079964 MirTarget;miRNATAP -0.165467093080228 0.031397302909633 NA NA NA hsa-miR-127-3p PMCHL2 0.231539840651733 0.822108193638849 -0.407429204891316 0.516459484189933 miRanda -0.22357827277607 0.0211114097203116 NA NA NA hsa-miR-107 PMEPA1 -0.289737369453023 0.769655185893943 0.272139744477033 0.649605523427582 mirMAP -0.396968521258116 4.44556481698755e-05 NA NA NA hsa-miR-129-5p PMP22 0.417083435812871 0.454236109516901 0.60741367565053 0.234143796190441 miRanda -0.146934549011803 8.06754591377314e-05 NA NA NA hsa-miR-361-5p PMP22 -0.278147578656315 0.728553069590798 0.60741367565053 0.234143796190441 miRanda -0.310119358799281 0.00100947781760079 NA NA NA hsa-miR-9-5p PMP22 0.029299723902132 0.964227616086639 0.60741367565053 0.234143796190441 MirTarget;miRNATAP -0.148781605865606 2.37200238675537e-06 NA NA NA hsa-miR-107 PNMA2 -0.289737369453023 0.769655185893943 0.852892799017383 0.0740286472342137 miRanda -0.474283044437771 0.000386047907820374 NA NA NA hsa-miR-107 PNMAL1 -0.289737369453023 0.769655185893943 0.0976456815400404 0.843598312844483 miRanda -0.146127086874155 0.0407080487904786 NA NA NA hsa-miR-15b-5p PNMAL2 0.251826642099145 0.790709218602499 -0.00948945445855776 0.975221515796783 MirTarget -0.195187183238563 0.00672006385695196 NA NA NA hsa-miR-130b-5p PODXL -0.318833907124358 0.508178803208229 0.0759045557935307 0.919441969589351 mirMAP -0.151264257237039 0.0331770663797056 NA NA NA hsa-miR-148b-3p PODXL 0.0855166854239631 0.914712779298241 0.0759045557935307 0.919441969589351 MirTarget -0.212755785633285 0.0244608209404336 NA NA NA hsa-miR-29b-2-5p PODXL -0.0876372630441624 0.860453852037775 0.0759045557935307 0.919441969589351 mirMAP -0.149692914234098 0.0309774910751552 NA NA NA hsa-miR-339-5p PODXL -0.121565674268033 0.81427862647099 0.0759045557935307 0.919441969589351 PITA -0.155753417755266 0.0211370920243301 NA NA NA hsa-miR-361-3p PODXL -0.398826925662302 0.617283381786186 0.0759045557935307 0.919441969589351 MirTarget -0.192934835724492 0.0147117282646231 NA NA NA hsa-miR-532-3p PODXL 0.102082509259256 0.893896651717717 0.0759045557935307 0.919441969589351 mirMAP -0.132316704205302 0.0185572019513142 NA NA NA hsa-miR-22-3p POGK 0.0468440219945929 0.967778504781139 -0.0115733232792978 0.984631863182894 MirTarget -0.106293973298418 5.50193946966233e-06 NA NA NA hsa-miR-221-3p POGZ -0.261179092929062 0.744019631321393 -0.235892612080695 0.706396323124935 miRNAWalker2_validate;MirTarget;miRNATAP -0.106559367520748 0.000846818306236619 NA NA NA hsa-miR-222-3p POGZ -0.233673471709747 0.726651775432807 -0.235892612080695 0.706396323124935 MirTarget;miRNATAP -0.120219577937646 0.000141505699727378 NA NA NA hsa-miR-107 POLDIP3 -0.289737369453023 0.769655185893943 0.126041408089588 0.821396558853154 miRanda -0.143451688646447 1.43549435047125e-05 NA NA NA hsa-miR-125a-3p POLR2H 0.124026360619668 0.800539414590835 0.168998778017926 0.759425293528337 miRanda -0.126703272884576 0.00479569146362008 NA NA NA hsa-miR-127-3p POLR2H 0.231539840651733 0.822108193638849 0.168998778017926 0.759425293528337 miRanda -0.107168842725767 9.40934690574851e-06 NA NA NA hsa-miR-423-5p POLR2H -0.314923545892784 0.658894400879422 0.168998778017926 0.759425293528337 MirTarget -0.134735572534017 0.00282980081777024 NA NA NA hsa-miR-338-3p POLR2K -0.107178830331044 0.818042702366464 0.243941359661777 0.676639038249632 miRanda -0.140821274389879 7.85363100090694e-08 NA NA NA hsa-miR-361-5p POLR2K -0.278147578656315 0.728553069590798 0.243941359661777 0.676639038249632 miRanda -0.250349119031087 4.61458876865514e-05 NA NA NA hsa-miR-140-3p POU2F1 -0.105651799466207 0.9077781740714 -0.0897505518405097 0.804089556136389 miRNATAP -0.101159458402662 0.00493317240534037 NA NA NA hsa-miR-98-5p POU2F1 -0.0484028619275874 0.910781316485549 -0.0897505518405097 0.804089556136389 miRNAWalker2_validate -0.100174146068798 9.99358191230628e-05 NA NA NA hsa-miR-107 PPARGC1A -0.289737369453023 0.769655185893943 0.229210326094991 0.732721990004139 miRanda -0.664703058278635 0.000769410038554476 NA NA NA hsa-miR-660-5p PPARGC1A -0.561687438133488 0.138270972367544 0.229210326094991 0.732721990004139 MirTarget -0.401809674353636 0.00117803120762303 NA NA NA hsa-miR-98-5p PPARGC1A -0.0484028619275874 0.910781316485549 0.229210326094991 0.732721990004139 miRNAWalker2_validate -0.534634774592048 3.98468956778339e-05 NA NA NA hsa-miR-140-3p PPM1E -0.105651799466207 0.9077781740714 -0.581399323842226 0.104476141184556 PITA -0.194214859365269 0.0466089613715106 NA NA NA hsa-miR-222-3p PPM1H -0.233673471709747 0.726651775432807 -0.231376673890774 0.628806404083338 miRNAWalker2_validate -0.268562441934676 1.25932231136323e-05 NA NA NA hsa-miR-221-3p PPM1L -0.261179092929062 0.744019631321393 0.0646545898150893 0.833664564331168 mirMAP -0.142540621796254 0.0394235005720516 NA NA NA hsa-miR-331-3p PPP1R14B 0.123898581478304 0.82138091232147 -0.036628527092625 0.949538300413195 miRNATAP -0.121077616923775 0.00774811710398731 NA NA NA hsa-miR-222-3p PPP1R15B -0.233673471709747 0.726651775432807 0.119709240536804 0.833589551762516 miRNATAP -0.100759036325955 2.26988136778482e-05 NA NA NA hsa-miR-222-3p PPP2R1A -0.233673471709747 0.726651775432807 -0.0909267516111996 0.902810099795045 miRNAWalker2_validate -0.100901724091199 5.87904961517037e-05 NA NA NA hsa-miR-140-3p PPP2R2A -0.105651799466207 0.9077781740714 0.0894716803567892 0.860054904608835 PITA -0.115623103061531 0.00134848401333295 NA NA NA hsa-miR-30e-3p PPP2R2B 0.202355073367528 0.857417040078429 0.314329392673009 0.614618645525958 miRNAWalker2_validate -0.856543491580229 1.01463010899578e-05 NA NA NA hsa-miR-125a-3p PPP4C 0.124026360619668 0.800539414590835 0.044424656765818 0.943639610168575 miRanda -0.155186230994984 0.000111490281215564 NA NA NA hsa-miR-27b-3p PPP4C 0.306246927737414 0.735781270461428 0.044424656765818 0.943639610168575 miRNATAP -0.1030113721359 0.0023911952244754 NA NA NA hsa-miR-320a PPP4C 0.142884703798297 0.888511174254355 0.044424656765818 0.943639610168575 miRNAWalker2_validate -0.139964749995375 2.60084864892664e-05 NA NA NA hsa-miR-125a-5p PRC1 -0.00666761469427968 0.994891296705929 -0.274642401483733 0.595153483783258 miRNAWalker2_validate -0.433714007075154 2.28225976661979e-08 NA NA NA hsa-miR-1275 PRC1 0.524790554828265 0.301913533762167 -0.274642401483733 0.595153483783258 MirTarget -0.11959866039987 3.70667540130636e-05 NA NA NA hsa-miR-199a-5p PRC1 0.248253058498817 0.7461266806999 -0.274642401483733 0.595153483783258 miRanda -0.109338424942842 0.00124369531851722 NA NA NA hsa-miR-27a-3p PRDM16 0.309634509674364 0.703724209648479 -0.421541536732908 0.443431196347576 miRNATAP -0.387635170045288 0.00669787953449951 NA NA NA hsa-let-7b-5p PRIM1 0.396604576702067 0.783406687058469 0.245971392399357 0.442197847234581 miRNAWalker2_validate -0.117247641651461 0.0149351452921103 NA NA NA hsa-miR-24-3p PRIM1 0.0408517902063537 0.966828370841971 0.245971392399357 0.442197847234581 miRNAWalker2_validate -0.133678629995044 0.0255996045092403 NA NA NA hsa-miR-15b-5p PRKAB2 0.251826642099145 0.790709218602499 -0.0425914327641346 0.921896129536125 MirTarget -0.203802540972703 8.97755216288407e-06 NA NA NA hsa-miR-107 PRKAR2B -0.289737369453023 0.769655185893943 0.126375628714293 0.767754021691009 miRanda -0.249986923023997 0.000604369206896498 NA NA NA hsa-miR-128-3p PRKD1 -0.0364518492233463 0.95841670253784 0.0695626146272637 0.844746418382669 MirTarget -0.181599066986914 0.0230153411578755 NA NA NA hsa-miR-107 PRKG1 -0.289737369453023 0.769655185893943 0.628053453885595 0.0850532587038029 PITA;miRanda;miRNATAP -0.282451724168133 0.00930022086762739 NA NA NA hsa-miR-15b-5p PRMT7 0.251826642099145 0.790709218602499 0.0154030235351819 0.969743625575252 mirMAP -0.13420089978783 0.000205390945373842 NA NA NA hsa-miR-324-5p PROS1 -0.358991607952497 0.499732551112182 0.0713356501936371 0.876775973694082 miRanda -0.143907437385824 0.0435776323938223 NA NA NA hsa-miR-375 PROS1 -0.989394125724925 0.312728638150002 0.0713356501936371 0.876775973694082 miRanda -0.121049229960206 9.08484450017286e-05 NA NA NA hsa-miR-107 PRPS2 -0.289737369453023 0.769655185893943 0.132654529610422 0.798387835976665 miRanda -0.117011481782589 0.0237644489830253 NA NA NA hsa-miR-214-3p PRR15L 0.0312810611346688 0.952640488671912 0.225584482065991 0.661394552629711 MirTarget;miRNATAP -0.125352534543079 0.0270072164792573 NA NA NA hsa-miR-107 PRR5 -0.289737369453023 0.769655185893943 -0.107751043552081 0.789874455685381 miRanda -0.140522359715997 0.00540857342114622 NA NA NA hsa-miR-98-5p PRRG3 -0.0484028619275874 0.910781316485549 -0.438271363333693 0.464513634826601 mirMAP -0.46514303048606 1.19673712652242e-05 NA NA NA hsa-miR-22-3p PRRT2 0.0468440219945929 0.967778504781139 -0.0449048418559226 0.897651077368752 miRNATAP -0.237381412769232 0.000688433381415815 NA NA NA hsa-miR-107 PRRT4 -0.289737369453023 0.769655185893943 -0.11019880211934 0.812372931085144 miRNATAP -0.269190280260806 0.0356971522545947 NA NA NA hsa-miR-27a-3p PRRT4 0.309634509674364 0.703724209648479 -0.11019880211934 0.812372931085144 miRNATAP -0.30165133035757 0.00683670414002915 NA NA NA hsa-miR-107 PRTG -0.289737369453023 0.769655185893943 0.728893879908849 0.0586026605838627 miRanda;miRNATAP -0.446840421440558 8.65288246950172e-05 NA NA NA hsa-miR-15b-5p PRTG 0.251826642099145 0.790709218602499 0.728893879908849 0.0586026605838627 MirTarget -0.715018105109121 6.0168886217655e-10 NA NA NA hsa-miR-221-3p PRTG -0.261179092929062 0.744019631321393 0.728893879908849 0.0586026605838627 mirMAP -0.24801747616276 0.00589869086584545 NA NA NA hsa-miR-222-3p PRTG -0.233673471709747 0.726651775432807 0.728893879908849 0.0586026605838627 mirMAP -0.218669838703352 0.0145513114390954 NA NA NA hsa-miR-130b-3p PRUNE2 -0.246958204594817 0.524070870130445 0.389155691932366 0.516529986422692 miRNAWalker2_validate -0.189461754926323 0.0410588479866717 NA NA NA hsa-miR-342-3p PRUNE2 -0.233020179388453 0.739959578456401 0.389155691932366 0.516529986422692 miRanda -0.229847398987529 0.0260763730028909 NA NA NA hsa-miR-539-5p PRUNE2 0.551428040760553 0.139269787059339 0.389155691932366 0.516529986422692 mirMAP -0.13735649971651 0.0235360665297501 NA NA NA hsa-miR-107 PRX -0.289737369453023 0.769655185893943 -0.264781709906133 0.396464797669974 mirMAP -0.131963678505916 0.0474882468330128 NA NA NA hsa-miR-342-3p PSAT1 -0.233020179388453 0.739959578456401 0.0161347173916448 0.980624676510205 miRNAWalker2_validate -0.28653363780644 0.000178163868795533 NA NA NA hsa-miR-501-3p PSAT1 0.272254003876544 0.713437785858009 0.0161347173916448 0.980624676510205 miRNATAP -0.111624780765536 0.0256978186028248 NA NA NA hsa-miR-502-3p PSAT1 -0.161049433579914 0.724644527567453 0.0161347173916448 0.980624676510205 miRNATAP -0.215627963709495 0.00139795725741996 NA NA NA hsa-miR-381-3p PSIP1 0.269633663970002 0.562625029053898 0.0466864224704349 0.935436890147336 MirTarget -0.112528253033982 0.000572781168714855 NA NA NA hsa-miR-15b-5p PSKH1 0.251826642099145 0.790709218602499 0.00637985193952417 0.989520075243675 MirTarget;miRNATAP -0.252146927853935 1.13853333979636e-10 NA NA NA hsa-miR-222-3p PSMC4 -0.233673471709747 0.726651775432807 -0.00253373973214543 0.996814059006204 miRNAWalker2_validate -0.119399610239256 0.00399633160393218 NA NA NA hsa-let-7b-3p PSME4 0.314328399485033 0.684245834514538 -0.111868995870251 0.839976934675976 miRNATAP -0.131002643565339 2.792993625749e-05 NA NA NA hsa-miR-193b-3p PSRC1 0.228475522385047 0.747332810847705 -0.334784479578106 0.429141211836455 miRNAWalker2_validate -0.107035467926998 0.0291074940476801 NA NA NA hsa-miR-127-3p PTBP2 0.231539840651733 0.822108193638849 0.0101102906172699 0.98201841107918 miRanda -0.109085435091481 0.00348824015643427 NA NA NA hsa-miR-132-3p PTBP2 -0.274411442405805 0.710467071857645 0.0101102906172699 0.98201841107918 miRNATAP -0.129571274614457 0.0112040789076101 NA NA NA hsa-miR-199a-5p PTBP2 0.248253058498817 0.7461266806999 0.0101102906172699 0.98201841107918 miRanda -0.132705842234521 0.000265651349339602 NA NA NA hsa-miR-212-3p PTBP2 -0.118513342558296 0.740632149411935 0.0101102906172699 0.98201841107918 miRNATAP -0.123278031113939 0.00501610105895245 NA NA NA hsa-miR-320a PTBP2 0.142884703798297 0.888511174254355 0.0101102906172699 0.98201841107918 miRanda -0.16632740878675 0.00353971390419254 NA NA NA hsa-miR-330-5p PTBP2 -0.152605584680815 0.787259112745893 0.0101102906172699 0.98201841107918 miRanda -0.139487496493013 0.0100862362490288 NA NA NA hsa-miR-365a-3p PTBP2 0.343543107096282 0.577093517084808 0.0101102906172699 0.98201841107918 miRNATAP -0.153911490202129 0.0252143690876232 NA NA NA hsa-miR-15b-5p PTCH1 0.251826642099145 0.790709218602499 -0.128876869443368 0.772081528057187 miRNATAP -0.177708381172835 0.00243070480070398 NA NA NA hsa-miR-221-3p PTCHD1 -0.261179092929062 0.744019631321393 -0.836467355669392 0.172950952034276 mirMAP -0.262651949397208 0.0446222396539873 NA NA NA hsa-miR-363-3p PTGER3 -0.186046567396088 0.728622856049059 1.5042382236434 0.00750024599878325 mirMAP -0.195090129151484 0.0111893840107225 NA NA NA hsa-miR-107 PTGIS -0.289737369453023 0.769655185893943 0.708673313204939 0.233374004519277 miRanda -0.45895937230738 0.000191471571500375 NA NA NA hsa-miR-22-3p PTMS 0.0468440219945929 0.967778504781139 0.187086412232667 0.812010182196003 miRNAWalker2_validate;miRTarBase -0.124840407541086 0.0013541898063031 NA NA NA hsa-miR-107 PTPN13 -0.289737369453023 0.769655185893943 -0.118911044770142 0.843548078156716 miRanda -0.325278017929708 0.0278221597058042 NA NA NA hsa-miR-148a-3p PTPN14 -0.324144803192141 0.746264759480212 0.0640945989806028 0.88112748225223 MirTarget;miRNATAP -0.125773659379551 0.00301631556968832 NA NA NA hsa-miR-130b-5p PTPN3 -0.318833907124358 0.508178803208229 -0.0109972154490903 0.981471174208379 mirMAP -0.107713711367738 0.0318372646987778 NA NA NA hsa-miR-616-5p PTPRG -0.321509218120179 0.271446046739636 -0.0952445287396211 0.850116852325782 mirMAP -0.102101037898627 0.0198787541653952 NA NA NA hsa-miR-146b-5p PTPRK 0.0340352805627226 0.964565988329585 -0.00863486523746726 0.987370890048383 miRanda -0.108487370783099 0.00319237202058058 NA NA NA hsa-miR-582-3p PTPRK -0.412732829130276 0.327362626701922 -0.00863486523746726 0.987370890048383 miRNATAP -0.111377116099688 0.000107363520335373 NA NA NA hsa-miR-139-5p PTPRO -0.0625698939687087 0.914810329989088 -0.0470623163469455 0.889506548719835 miRanda -0.15722197267573 0.0232294579639625 NA NA NA hsa-miR-150-5p PTPRT -0.00683324482969283 0.994067057151257 1.26309147338408 0.131785433872241 mirMAP -0.314654889609647 0.00849478764676735 NA NA NA hsa-miR-16-5p PTPRT -0.199225750365017 0.742834324195084 1.26309147338408 0.131785433872241 miRNAWalker2_validate -0.575137484839666 0.00735769572886862 NA NA NA hsa-miR-20a-5p PTPRT -0.857283498361138 0.070259604943771 1.26309147338408 0.131785433872241 miRNATAP -0.386611101830393 0.0117715670691302 NA NA NA hsa-miR-21-5p PTPRT -0.515762857245393 0.64198914412298 1.26309147338408 0.131785433872241 mirMAP -0.445028385361194 0.00240514236575292 NA NA NA hsa-miR-223-3p PTPRT -0.219863334942404 0.708457258631868 1.26309147338408 0.131785433872241 mirMAP -0.312595370170793 0.026535958510966 NA NA NA hsa-miR-362-5p PTPRT -0.35564884735017 0.452162806620853 1.26309147338408 0.131785433872241 mirMAP -0.658132781957184 7.32550637501586e-06 NA NA NA hsa-miR-425-5p PTPRT -0.260590453490611 0.72116723892515 1.26309147338408 0.131785433872241 mirMAP -0.748326701935019 0.000429185420276679 NA NA NA hsa-miR-576-5p PTPRT -0.521065838204864 0.11793493718786 1.26309147338408 0.131785433872241 mirMAP -0.541204197538146 0.00280266231123057 NA NA NA hsa-miR-616-5p PTPRT -0.321509218120179 0.271446046739636 1.26309147338408 0.131785433872241 mirMAP -0.579619549304008 0.000798782201966329 NA NA NA hsa-miR-636 PTPRT -0.112545138850734 0.710621887575005 1.26309147338408 0.131785433872241 mirMAP -0.504498621193221 0.00483080268887286 NA NA NA hsa-miR-877-5p PTPRT -0.734829979266612 0.187061190699743 1.26309147338408 0.131785433872241 mirMAP -0.428941495950782 0.01850354539144 NA NA NA hsa-miR-26a-5p PTTG1 0.0483232931294246 0.955218190818435 0.0875455171058821 0.862508142708178 miRNAWalker2_validate -0.395458163360483 2.13600889878479e-07 NA NA NA hsa-miR-107 PURG -0.289737369453023 0.769655185893943 0.119181666258185 0.790364135546391 miRanda -0.270468523614843 0.0310149866401141 NA NA NA hsa-miR-107 PWWP2B -0.289737369453023 0.769655185893943 0.130397728414171 0.774733655350266 miRNATAP -0.120047016346125 0.0100232828889516 NA NA NA hsa-miR-192-5p PXDN -0.00281508349767456 0.99638352116085 -0.0955260730983865 0.893670796574073 miRNAWalker2_validate -0.152323249211905 0.00632820685168045 NA NA NA hsa-miR-29b-3p PXDN -0.249746665931503 0.558208927436524 -0.0955260730983865 0.893670796574073 MirTarget;miRNATAP -0.1170034330872 0.0211615063713035 NA NA NA hsa-miR-29c-3p PXDN 0.042533372292219 0.941334605544826 -0.0955260730983865 0.893670796574073 MirTarget;miRNATAP -0.151273356160395 0.00954214765417089 NA NA NA hsa-miR-505-3p PXDN -0.101578624236243 0.868681779756913 -0.0955260730983865 0.893670796574073 mirMAP -0.280991064491732 0.0017567041531238 NA NA NA hsa-miR-34a-5p PYCR1 -0.689845719362998 0.195745632660671 -0.0581645030562585 0.917942308222135 miRNAWalker2_validate -0.10449128864905 0.026809195468038 NA NA NA hsa-miR-140-3p PYCRL -0.105651799466207 0.9077781740714 0.0792590669681008 0.877484713479432 mirMAP -0.22461367792228 8.52187440723636e-05 NA NA NA hsa-miR-139-5p PYROXD1 -0.0625698939687087 0.914810329989088 0.324261896314824 0.426700469660031 miRanda -0.107053352036801 0.0067756585473485 NA NA NA hsa-miR-28-5p PYROXD1 -0.0511712157419266 0.910958192291954 0.324261896314824 0.426700469660031 miRanda -0.120737379591473 0.015472094805444 NA NA NA hsa-miR-127-3p PYROXD2 0.231539840651733 0.822108193638849 -0.204452019842756 0.571113407161471 miRanda -0.148608250356679 0.00300228407956668 NA NA NA hsa-miR-150-5p QSOX2 -0.00683324482969283 0.994067057151257 -0.136054280096601 0.740534624178366 mirMAP -0.110606764488976 4.09995889609151e-07 NA NA NA hsa-miR-106b-5p RAB11FIP1 -0.3941595235172 0.389635342155994 -0.139195207774124 0.801370974532325 MirTarget -0.1384796563753 0.0220456225183074 NA NA NA hsa-miR-146b-5p RAB11FIP1 0.0340352805627226 0.964565988329585 -0.139195207774124 0.801370974532325 mirMAP -0.115099892476365 0.00648609853746259 NA NA NA hsa-miR-17-3p RAB11FIP1 -0.13137566263129 0.849946548607015 -0.139195207774124 0.801370974532325 MirTarget -0.112693148856087 0.0496306651140962 NA NA NA hsa-miR-17-5p RAB11FIP1 -0.643066792834501 0.320674049526638 -0.139195207774124 0.801370974532325 MirTarget;TargetScan -0.101177431596581 0.0379427392849126 NA NA NA hsa-miR-93-5p RAB11FIP1 -0.375078982324499 0.732311284477601 -0.139195207774124 0.801370974532325 miRNAWalker2_validate;MirTarget -0.143505796569738 0.0126581787178838 NA NA NA hsa-miR-15b-5p RAB11FIP2 0.251826642099145 0.790709218602499 0.40796246475975 0.390424686419944 MirTarget;miRNATAP -0.157421190478006 0.00223085120900179 NA NA NA hsa-miR-128-3p RAB20 -0.0364518492233463 0.95841670253784 0.21643465232716 0.622700124000527 MirTarget -0.121279322268143 0.0306388530717531 NA NA NA hsa-miR-22-3p RAB28 0.0468440219945929 0.967778504781139 0.00500086875734862 0.989445493140187 MirTarget -0.111651977506877 0.000206839632654452 NA NA NA hsa-miR-320c RAB36 0.092255964601645 0.785539881268253 0.138185192139415 0.7547346326844 mirMAP -0.121776786088656 0.0335349936164091 NA NA NA hsa-miR-484 RAB36 0.0718403983730163 0.919121336841307 0.138185192139415 0.7547346326844 miRNAWalker2_validate -0.157742213823081 0.0364688684216134 NA NA NA hsa-miR-107 RAB37 -0.289737369453023 0.769655185893943 -0.0678665561639503 0.801799409694824 miRanda -0.17782594185439 0.0243240144590729 NA NA NA hsa-miR-15b-5p RAB37 0.251826642099145 0.790709218602499 -0.0678665561639503 0.801799409694824 mirMAP -0.22767953236208 0.00522431885163684 NA NA NA hsa-miR-214-3p RAB39B 0.0312810611346688 0.952640488671912 0.108587482783994 0.755483545334207 MirTarget -0.100204313867329 0.0376818002415697 NA NA NA hsa-miR-15b-5p RAB6B 0.251826642099145 0.790709218602499 0.25499690713575 0.610671139960455 mirMAP -0.156464764620171 0.026994233454671 NA NA NA hsa-miR-363-3p RAB6B -0.186046567396088 0.728622856049059 0.25499690713575 0.610671139960455 mirMAP -0.108924126860862 0.000854232071469155 NA NA NA hsa-miR-15b-5p RAB9B 0.251826642099145 0.790709218602499 -0.456852331489163 0.25388961484004 miRNATAP -0.26364045286316 0.0107567401771477 NA NA NA hsa-let-7e-5p RACGAP1 -0.421901553764044 0.703151344854989 0.0481665178996566 0.926277360869014 miRNAWalker2_validate -0.103407002109921 0.0443004182481233 NA NA NA hsa-miR-125a-5p RACGAP1 -0.00666761469427968 0.994891296705929 0.0481665178996566 0.926277360869014 miRanda -0.36775056916534 2.24820131237059e-07 NA NA NA hsa-miR-221-3p RACGAP1 -0.261179092929062 0.744019631321393 0.0481665178996566 0.926277360869014 miRNAWalker2_validate -0.121284794523858 0.00317082905986859 NA NA NA hsa-miR-320c RACGAP1 0.092255964601645 0.785539881268253 0.0481665178996566 0.926277360869014 miRanda -0.116524844173036 0.00338856534420555 NA NA NA hsa-miR-141-3p RAD1 -0.36932301319088 0.428364456128406 -0.0761465371385786 0.860750092074278 MirTarget -0.103853515280736 0.000765898566008172 NA NA NA hsa-miR-26a-5p RAD1 0.0483232931294246 0.955218190818435 -0.0761465371385786 0.860750092074278 mirMAP -0.242833882002245 4.41501508044507e-09 NA NA NA hsa-miR-26b-5p RAD1 0.16143906971203 0.790777916193478 -0.0761465371385786 0.860750092074278 mirMAP -0.108345347592758 0.0101312659218558 NA NA NA hsa-miR-361-5p RAD1 -0.278147578656315 0.728553069590798 -0.0761465371385786 0.860750092074278 miRNATAP -0.108259251994168 0.0311290380845999 NA NA NA hsa-miR-181a-5p RAD21 -0.0320774839604816 0.975806098950371 -0.0682229778666326 0.925365740842457 MirTarget;miRNATAP -0.129157505355795 0.000858943464364343 NA NA NA hsa-miR-181b-5p RAD21 -0.0483087651223055 0.952929800264921 -0.0682229778666326 0.925365740842457 MirTarget;miRNATAP -0.118365681896331 0.0015621764941682 NA NA NA hsa-miR-181c-5p RAD21 -0.262596734125804 0.645471285705202 -0.0682229778666326 0.925365740842457 MirTarget;miRNATAP -0.104815492572882 0.00067187550909933 NA NA NA hsa-miR-30a-3p RAD21 0.11336767305191 0.920646436414994 -0.0682229778666326 0.925365740842457 MirTarget -0.119846629628426 0.000280474907673509 NA NA NA hsa-miR-30e-3p RAD21 0.202355073367528 0.857417040078429 -0.0682229778666326 0.925365740842457 MirTarget -0.133744465841767 0.00374503973159566 NA NA NA hsa-miR-23a-3p RAD51AP1 0.174045248211037 0.865717934161724 -0.176580943026923 0.656572437042351 MirTarget -0.17292258827731 0.00519038541978977 NA NA NA hsa-miR-23b-3p RAD51AP1 0.188949711826471 0.848360545615343 -0.176580943026923 0.656572437042351 MirTarget -0.19756923766561 0.000434919741189082 NA NA NA hsa-miR-320c RAD51AP1 0.092255964601645 0.785539881268253 -0.176580943026923 0.656572437042351 miRanda -0.140309835419424 0.00273769777017946 NA NA NA hsa-miR-664a-3p RAD51AP1 -0.139841943049965 0.800834383581795 -0.176580943026923 0.656572437042351 MirTarget -0.368902022808071 1.37994655745658e-11 NA NA NA hsa-miR-127-3p RAD9A 0.231539840651733 0.822108193638849 -0.153181494059183 0.699997889067489 miRanda;miRNATAP -0.106717103557534 4.46003097466537e-06 NA NA NA hsa-miR-150-5p RADIL -0.00683324482969283 0.994067057151257 0.0950694612290111 0.821511996013504 mirMAP -0.133475142722219 0.0235142818818496 NA NA NA hsa-miR-148a-3p RAI14 -0.324144803192141 0.746264759480212 0.0965787852806113 0.86653189464539 MirTarget -0.130945463181297 0.0111748545535761 NA NA NA hsa-miR-27b-3p RALA 0.306246927737414 0.735781270461428 -0.0120762635878773 0.982207029803598 miRNATAP -0.109587868687167 0.000851664755625885 NA NA NA hsa-miR-148a-3p RALGPS1 -0.324144803192141 0.746264759480212 -0.223412409373529 0.602341853925744 mirMAP -0.120843104036247 0.0034168588777847 NA NA NA hsa-miR-197-3p RALGPS1 0.0240027695773914 0.981971058073739 -0.223412409373529 0.602341853925744 miRNATAP -0.19541349124182 0.00033308473429568 NA NA NA hsa-miR-15b-5p RANBP10 0.251826642099145 0.790709218602499 -0.168749543564748 0.714373377843494 miRNAWalker2_validate;mirMAP -0.12013844076915 0.00235877561114348 NA NA NA hsa-miR-222-3p RAP1GAP2 -0.233673471709747 0.726651775432807 -0.396747626151487 0.419794571173759 miRNAWalker2_validate -0.179715492569592 0.00882934029547843 NA NA NA hsa-miR-15b-5p RAPGEF2 0.251826642099145 0.790709218602499 -0.177866081352616 0.661243598364709 miRNATAP -0.116008667039147 0.00515366681483131 NA NA NA hsa-miR-127-3p RAPGEF3 0.231539840651733 0.822108193638849 0.42116693587348 0.48319683956781 miRanda -0.110861231885597 0.0448096275067771 NA NA NA hsa-miR-107 RARB -0.289737369453023 0.769655185893943 0.74003577086304 0.0380123435177395 miRanda -0.202220432887224 0.0146841176579394 NA NA NA hsa-miR-15b-5p RASA4 0.251826642099145 0.790709218602499 -0.152044566952539 0.710915884115039 mirMAP -0.121655360144953 0.0315324067427922 NA NA NA hsa-miR-214-3p RASEF 0.0312810611346688 0.952640488671912 -0.403334380279583 0.266893169484835 MirTarget -0.199069256294127 5.9276500449734e-05 NA NA NA hsa-miR-107 RASL12 -0.289737369453023 0.769655185893943 0.135440723734943 0.683089331172494 miRNATAP -0.16188785461667 0.0161257020106291 NA NA NA hsa-miR-15b-5p RASL12 0.251826642099145 0.790709218602499 0.135440723734943 0.683089331172494 miRNATAP -0.205940807398858 0.0030220706813014 NA NA NA hsa-miR-16-5p RASL12 -0.199225750365017 0.742834324195084 0.135440723734943 0.683089331172494 miRNATAP -0.214423584870662 0.000170764136421095 NA NA NA hsa-miR-30d-5p RASL12 -0.127037899273548 0.917197761243139 0.135440723734943 0.683089331172494 miRNATAP -0.217659752594439 0.000719214621853864 NA NA NA hsa-miR-17-3p RASSF2 -0.13137566263129 0.849946548607015 0.0265081914185208 0.950975563016588 mirMAP -0.167135563651733 0.00199179538025286 NA NA NA hsa-miR-181c-5p RASSF2 -0.262596734125804 0.645471285705202 0.0265081914185208 0.950975563016588 MirTarget -0.174716418465677 5.56438706084967e-05 NA NA NA hsa-miR-181d-5p RASSF2 -0.294264170071504 0.604392929232074 0.0265081914185208 0.950975563016588 MirTarget -0.121998357583214 0.0014349714012562 NA NA NA hsa-miR-25-3p RASSF2 0.0681841609869576 0.955267320175687 0.0265081914185208 0.950975563016588 mirMAP -0.155376596985016 0.0225844606380279 NA NA NA hsa-miR-30e-3p RASSF2 0.202355073367528 0.857417040078429 0.0265081914185208 0.950975563016588 MirTarget -0.221503278367172 0.000651268020677522 NA NA NA hsa-miR-92a-3p RASSF2 0.0155161307487504 0.991444817308063 0.0265081914185208 0.950975563016588 mirMAP -0.224441460231307 0.000525557311007541 NA NA NA hsa-miR-92b-3p RASSF2 0.454620627632174 0.646193882241421 0.0265081914185208 0.950975563016588 mirMAP -0.118539629456126 0.00509520457422894 NA NA NA hsa-miR-107 RASSF8 -0.289737369453023 0.769655185893943 -0.0372484633947416 0.939873761407767 miRanda;miRNATAP -0.35151830858354 0.00062043452426105 NA NA NA hsa-miR-214-3p RAX2 0.0312810611346688 0.952640488671912 -0.139182355951872 0.821567837593563 mirMAP -0.333870364827163 0.000119213510362658 NA NA NA hsa-miR-140-3p RBM15B -0.105651799466207 0.9077781740714 -0.0776201449520606 0.896810037136899 PITA -0.119387017770286 1.98354400889807e-05 NA NA NA hsa-miR-107 RBMS3 -0.289737369453023 0.769655185893943 0.161532142045121 0.632183509346894 miRanda -0.269456315604729 0.00716590406581893 NA NA NA hsa-miR-22-3p RBMXL1 0.0468440219945929 0.967778504781139 -0.0941880589804507 0.855311454757308 MirTarget -0.140543678077435 1.70207005398913e-08 NA NA NA hsa-miR-182-5p RBPMS -0.262297863136789 0.8110070165759 0.329272859646026 0.533252002371631 mirMAP -0.191446601479227 1.1685840466145e-05 NA NA NA hsa-miR-27a-3p RBPMS2 0.309634509674364 0.703724209648479 -0.446890958835056 0.206057063891508 miRNATAP -0.302696913210883 7.24374032104023e-05 NA NA NA hsa-miR-107 RCAN2 -0.289737369453023 0.769655185893943 0.111174410976524 0.760340162186607 miRanda -0.151823322840372 0.0301883007984325 NA NA NA hsa-miR-107 RECK -0.289737369453023 0.769655185893943 0.240278891878698 0.465133407499922 miRanda -0.197538460806406 0.000277554359640023 NA NA NA hsa-miR-16-5p REEP1 -0.199225750365017 0.742834324195084 0.675794671738336 0.105241406862103 MirTarget -0.234225309865973 0.0206831642553473 NA NA NA hsa-miR-21-3p REEP1 0.129101420041684 0.877913267462969 0.675794671738336 0.105241406862103 MirTarget -0.251712526898564 0.00138510210812137 NA NA NA hsa-miR-30b-5p REEP1 -0.298771188216537 0.582864939841563 0.675794671738336 0.105241406862103 MirTarget -0.215128960881864 0.0217845327280016 NA NA NA hsa-miR-330-3p REEP1 -0.1562229971038 0.692313620862782 0.675794671738336 0.105241406862103 PITA;mirMAP;miRNATAP -0.29875900624294 0.00138781587008121 NA NA NA hsa-miR-330-5p REEP1 -0.152605584680815 0.787259112745893 0.675794671738336 0.105241406862103 miRanda -0.432719542031078 2.53513848533412e-05 NA NA NA hsa-miR-505-3p REEP1 -0.101578624236243 0.868681779756913 0.675794671738336 0.105241406862103 MirTarget -0.316437505174731 0.00849298500604681 NA NA NA hsa-miR-625-5p REEP1 -0.725005787172203 0.0605502864822602 0.675794671738336 0.105241406862103 MirTarget -0.235380711091727 0.000452528841352872 NA NA NA hsa-miR-214-3p REEP2 0.0312810611346688 0.952640488671912 0.170792853091597 0.662677842192033 mirMAP -0.108617290263007 0.0174032495554908 NA NA NA hsa-miR-200c-3p RELN -0.333638625701646 0.813830738880144 0.216114046950479 0.75281863475662 MirTarget -0.398591884871534 0.00505050873794728 NA NA NA hsa-miR-221-3p REV3L -0.261179092929062 0.744019631321393 -0.0343735837358246 0.934599358241077 miRNATAP -0.109322818727112 0.00712315737536437 NA NA NA hsa-miR-222-3p REV3L -0.233673471709747 0.726651775432807 -0.0343735837358246 0.934599358241077 miRNATAP -0.113437222825021 0.00486155310470137 NA NA NA hsa-miR-125a-3p RFC2 0.124026360619668 0.800539414590835 0.131776700427341 0.773123537293988 miRanda -0.125782353744035 0.0047943198007928 NA NA NA hsa-miR-744-5p RFC2 -0.168908767270826 0.802038726728767 0.131776700427341 0.773123537293988 MirTarget -0.169074499288029 2.89692664259695e-05 NA NA NA hsa-miR-181a-5p RFC3 -0.0320774839604816 0.975806098950371 -0.112896626768299 0.806120088567207 MirTarget -0.109882381064051 0.0206704978356254 NA NA NA hsa-miR-181c-5p RFC3 -0.262596734125804 0.645471285705202 -0.112896626768299 0.806120088567207 MirTarget -0.120594361413947 0.00134960151062603 NA NA NA hsa-miR-181d-5p RFC3 -0.294264170071504 0.604392929232074 -0.112896626768299 0.806120088567207 MirTarget -0.108050130005058 0.00107239178587221 NA NA NA hsa-miR-28-5p RFC3 -0.0511712157419266 0.910958192291954 -0.112896626768299 0.806120088567207 miRanda -0.169536426869408 0.00165010784365103 NA NA NA hsa-miR-125a-5p RFC5 -0.00666761469427968 0.994891296705929 -0.141619175035194 0.741046871577641 MirTarget;miRanda -0.19441735186784 0.000983947325704775 NA NA NA hsa-miR-140-3p RFT1 -0.105651799466207 0.9077781740714 0.071013176990574 0.875410399983397 miRNATAP -0.108032028164759 0.000918332813556308 NA NA NA hsa-miR-130b-5p RGL1 -0.318833907124358 0.508178803208229 -0.0577754840534102 0.907752019079093 mirMAP -0.18151544982082 0.000637637646913538 NA NA NA hsa-miR-17-5p RGL1 -0.643066792834501 0.320674049526638 -0.0577754840534102 0.907752019079093 MirTarget;TargetScan;miRNATAP -0.115064062678551 0.00933423732739035 NA NA NA hsa-miR-25-3p RGL1 0.0681841609869576 0.955267320175687 -0.0577754840534102 0.907752019079093 MirTarget -0.259043623180839 6.57062919390539e-05 NA NA NA hsa-miR-335-3p RGL1 0.0738544228922926 0.89349398283313 -0.0577754840534102 0.907752019079093 mirMAP -0.114812499375441 0.00183385496123179 NA NA NA hsa-miR-616-5p RGL1 -0.321509218120179 0.271446046739636 -0.0577754840534102 0.907752019079093 mirMAP -0.124957200528709 0.00191109220029548 NA NA NA hsa-miR-92b-3p RGL1 0.454620627632174 0.646193882241421 -0.0577754840534102 0.907752019079093 MirTarget -0.160234512872648 7.3382124176765e-05 NA NA NA hsa-miR-93-5p RGL1 -0.375078982324499 0.732311284477601 -0.0577754840534102 0.907752019079093 MirTarget;miRNATAP -0.124065386289719 0.0178994874256571 NA NA NA hsa-miR-148a-3p RGMA -0.324144803192141 0.746264759480212 -0.0868040418355855 0.866269824908491 miRNATAP -0.203831046930791 0.00333299375106034 NA NA NA hsa-miR-150-5p RHBDL3 -0.00683324482969283 0.994067057151257 -0.445360275416062 0.36566157903762 mirMAP -0.158575055994567 0.0202567226135721 NA NA NA hsa-miR-146b-5p RHOB 0.0340352805627226 0.964565988329585 0.290890966637097 0.660116278663077 miRanda -0.136227786318602 0.00141715852920654 NA NA NA hsa-miR-30d-5p RHOB -0.127037899273548 0.917197761243139 0.290890966637097 0.660116278663077 miRNATAP -0.16284389479572 0.0091774573179014 NA NA NA hsa-miR-27a-3p RHOBTB1 0.309634509674364 0.703724209648479 -0.0427306441823729 0.911470655663495 miRNATAP -0.197476889142609 0.000427645968087278 NA NA NA hsa-miR-98-5p RHOBTB3 -0.0484028619275874 0.910781316485549 0.499649335882288 0.290603099898554 miRNAWalker2_validate -0.152370371581659 0.00662998077122311 NA NA NA hsa-miR-342-3p RIF1 -0.233020179388453 0.739959578456401 -0.265620876091021 0.548202395434394 miRanda -0.103327136601931 0.00181389408567406 NA NA NA hsa-miR-30e-3p RIMBP2 0.202355073367528 0.857417040078429 0.983550125593142 0.0926904137974605 mirMAP -0.847784684785058 3.13922211031543e-06 NA NA NA hsa-miR-30e-5p RIMBP2 -0.00273037859886571 0.997115479601006 0.983550125593142 0.0926904137974605 MirTarget -0.53401125570138 0.00116134624199744 NA NA NA hsa-miR-324-5p RIMBP2 -0.358991607952497 0.499732551112182 0.983550125593142 0.0926904137974605 MirTarget;PITA;miRanda;miRNATAP -0.473218939627455 0.00174569766171808 NA NA NA hsa-miR-339-3p RIMBP2 -0.25498399202051 0.546144414599779 0.983550125593142 0.0926904137974605 PITA;miRNATAP -0.492758923676822 0.00233537228750168 NA NA NA hsa-miR-625-3p RIMBP2 -0.583300782744589 0.527323138903555 0.983550125593142 0.0926904137974605 MirTarget -0.304232838494356 0.0104731164690915 NA NA NA hsa-miR-15b-5p RIMKLB 0.251826642099145 0.790709218602499 -0.11484491184931 0.798695483786031 MirTarget;miRNATAP -0.106959138460666 0.0353651980070886 NA NA NA hsa-miR-17-5p RIMS2 -0.643066792834501 0.320674049526638 0.291453806929241 0.657296242890357 TargetScan -0.427495427524345 0.00388720139446135 NA NA NA hsa-miR-200c-3p RIMS2 -0.333638625701646 0.813830738880144 0.291453806929241 0.657296242890357 MirTarget -0.282876106004426 0.0376410761503636 NA NA NA hsa-miR-330-3p RIMS2 -0.1562229971038 0.692313620862782 0.291453806929241 0.657296242890357 mirMAP -0.33046309551431 0.0333825026738301 NA NA NA hsa-miR-92a-3p RIMS2 0.0155161307487504 0.991444817308063 0.291453806929241 0.657296242890357 MirTarget -0.693044804333216 0.000894114029467829 NA NA NA hsa-miR-107 RIMS3 -0.289737369453023 0.769655185893943 -0.844845493168377 0.0188893838516097 MirTarget;miRanda;miRNATAP -0.227204424686387 0.0134688705948389 NA NA NA hsa-miR-221-3p RIMS3 -0.261179092929062 0.744019631321393 -0.844845493168377 0.0188893838516097 MirTarget;miRNATAP -0.374761394496907 1.26742429273102e-07 NA NA NA hsa-miR-222-3p RIMS3 -0.233673471709747 0.726651775432807 -0.844845493168377 0.0188893838516097 MirTarget;miRNATAP -0.33887940845518 1.62503526163207e-06 NA NA NA hsa-miR-363-3p RIMS3 -0.186046567396088 0.728622856049059 -0.844845493168377 0.0188893838516097 mirMAP -0.120348942373461 0.00637113610038577 NA NA NA hsa-miR-221-3p RND2 -0.261179092929062 0.744019631321393 -0.149499377774948 0.710812385652947 miRNATAP -0.440821536492831 5.46151187083554e-07 NA NA NA hsa-miR-222-3p RND2 -0.233673471709747 0.726651775432807 -0.149499377774948 0.710812385652947 miRNATAP -0.39993309723228 5.0193858272833e-06 NA NA NA hsa-miR-128-3p RND3 -0.0364518492233463 0.95841670253784 -0.177158523229606 0.738936292787085 MirTarget -0.1696008397914 0.0184619052369757 NA NA NA hsa-miR-148a-5p RND3 -0.160202546137977 0.744679670526904 -0.177158523229606 0.738936292787085 miRNATAP -0.199771581764475 5.30990996680707e-05 NA NA NA hsa-miR-361-5p RND3 -0.278147578656315 0.728553069590798 -0.177158523229606 0.738936292787085 miRanda -0.244199774654393 0.00643972890761365 NA NA NA hsa-miR-93-5p RND3 -0.375078982324499 0.732311284477601 -0.177158523229606 0.738936292787085 miRNAWalker2_validate -0.1831056441134 0.0029768635164173 NA NA NA hsa-miR-942-5p RND3 -0.766562590119066 0.0293037013994827 -0.177158523229606 0.738936292787085 MirTarget -0.107166173639778 0.0313541974434899 NA NA NA hsa-miR-98-5p RND3 -0.0484028619275874 0.910781316485549 -0.177158523229606 0.738936292787085 miRNAWalker2_validate -0.126844785410505 0.00541117236736454 NA NA NA hsa-miR-342-3p RNF103 -0.233020179388453 0.739959578456401 -0.0167592902939226 0.973818419277613 miRanda -0.113445535924156 4.48354146869323e-05 NA NA NA hsa-miR-15b-5p RNF111 0.251826642099145 0.790709218602499 0.124748007892266 0.789366207632001 miRNATAP -0.10268771781242 0.00748384597330108 NA NA NA hsa-miR-139-5p RNF144A -0.0625698939687087 0.914810329989088 0.216002153487048 0.654723864324535 miRanda -0.105515165345172 0.0331693785154756 NA NA NA hsa-miR-148a-3p ROBO2 -0.324144803192141 0.746264759480212 -0.0317331177133265 0.943678653338893 miRNATAP -0.277812185340372 0.00790245294708686 NA NA NA hsa-miR-107 ROR1 -0.289737369453023 0.769655185893943 0.123791801842217 0.762992617950311 MirTarget;miRNATAP -0.17779560032767 0.0476084313386362 NA NA NA hsa-miR-27a-3p RORA 0.309634509674364 0.703724209648479 -0.106864420903452 0.76004561832972 mirMAP;miRNATAP -0.12744981856874 0.026750783314866 NA NA NA hsa-miR-342-3p RPGR -0.233020179388453 0.739959578456401 0.0207106757958972 0.955664373833792 miRanda -0.138590432318538 0.026242801494117 NA NA NA hsa-miR-107 RPL10 -0.289737369453023 0.769655185893943 0.0959738961819454 0.908641293809852 miRanda -0.235829714069353 1.04194968268601e-05 NA NA NA hsa-miR-22-3p RPL13 0.0468440219945929 0.967778504781139 0.469948641246376 0.603572845225541 MirTarget -0.215032481224803 4.74533011463888e-06 NA NA NA hsa-miR-197-3p RPL13A 0.0240027695773914 0.981971058073739 0.312781987413061 0.663891492149961 miRNAWalker2_validate -0.138015939536946 0.0213243096244712 NA NA NA hsa-miR-197-3p RPL22 0.0240027695773914 0.981971058073739 0.107062411048224 0.884260173817056 miRNAWalker2_validate -0.13412798645183 0.00521970041570858 NA NA NA hsa-miR-22-3p RPL24 0.0468440219945929 0.967778504781139 0.415560459468432 0.57289919111451 miRNAWalker2_validate -0.277610536501522 1.9402199991847e-11 NA NA NA hsa-miR-107 RPL27 -0.289737369453023 0.769655185893943 0.446713100165292 0.601582581088733 miRNAWalker2_validate -0.201224028478129 0.00174763604842161 NA NA NA hsa-miR-15b-5p RPL27A 0.251826642099145 0.790709218602499 0.395718819061685 0.62174323262406 miRNAWalker2_validate -0.158373288963581 0.0139240882665722 NA NA NA hsa-miR-128-3p RPL28 -0.0364518492233463 0.95841670253784 0.34263517940111 0.724499615995287 miRNAWalker2_validate -0.113839169738349 0.0481909276295563 NA NA NA hsa-miR-140-3p RPL28 -0.105651799466207 0.9077781740714 0.34263517940111 0.724499615995287 mirMAP -0.126802113304509 0.0123731440676046 NA NA NA hsa-miR-107 RPL32 -0.289737369453023 0.769655185893943 0.430467943148424 0.620231018841522 miRanda -0.166595466126211 0.00373098724068369 NA NA NA hsa-miR-107 RPL34 -0.289737369453023 0.769655185893943 0.423071604360283 0.545254545872231 miRanda -0.137948599723444 0.0197298730030315 NA NA NA hsa-miR-22-3p RPL35A 0.0468440219945929 0.967778504781139 0.44763490166746 0.594886845159278 miRNAWalker2_validate -0.235740012790426 3.3788657477439e-07 NA NA NA hsa-miR-381-3p RPL37 0.269633663970002 0.562625029053898 0.381374601741255 0.659861779181283 MirTarget -0.11274569095006 0.00153668345211754 NA NA NA hsa-miR-660-5p RPL37 -0.561687438133488 0.138270972367544 0.381374601741255 0.659861779181283 mirMAP -0.127869331604885 0.000310402233730636 NA NA NA hsa-miR-100-5p RPL39L 0.0542447471759004 0.961097766133859 0.00557899475659696 0.990223708012718 miRNAWalker2_validate -0.170688746920093 0.000159623142234836 NA NA NA hsa-miR-107 RPL5 -0.289737369453023 0.769655185893943 0.281783953809873 0.751162391690708 miRanda -0.187566608224084 0.000338159180118219 NA NA NA hsa-miR-15b-5p RPLP0 0.251826642099145 0.790709218602499 0.289170800840475 0.748792108206182 miRNAWalker2_validate -0.145908024310767 0.00901657664028096 NA NA NA hsa-miR-26b-5p RPN1 0.16143906971203 0.790777916193478 -0.000587312949225094 0.999419216556704 miRNAWalker2_validate -0.101542207415054 0.00750220778076502 NA NA NA hsa-miR-107 RPS19 -0.289737369453023 0.769655185893943 0.27636968755613 0.745174922819393 miRanda -0.171007815852254 0.00431756598106354 NA NA NA hsa-miR-22-3p RPS2 0.0468440219945929 0.967778504781139 0.213947913171545 0.803508778963472 miRNAWalker2_validate -0.189248939791968 1.88820904528945e-06 NA NA NA hsa-miR-361-5p RPS27L -0.278147578656315 0.728553069590798 0.430556870055547 0.344552690618386 miRanda -0.160476295241621 0.0126416008697791 NA NA NA hsa-miR-15b-5p RPS3A 0.251826642099145 0.790709218602499 0.357208884764124 0.598443743648107 miRNAWalker2_validate -0.133599666344082 0.0411639662664775 NA NA NA hsa-miR-22-3p RPS4X 0.0468440219945929 0.967778504781139 0.32392101190641 0.735179813082882 miRNAWalker2_validate -0.264971624015455 6.85886693619226e-10 NA NA NA hsa-miR-17-5p RPS6KA2 -0.643066792834501 0.320674049526638 -0.0979070012719347 0.852176769874365 TargetScan -0.137532795948713 0.00238252572073881 NA NA NA hsa-miR-636 RPS6KA2 -0.112545138850734 0.710621887575005 -0.0979070012719347 0.852176769874365 MirTarget -0.120216699395787 0.00485199967750594 NA NA NA hsa-miR-221-3p RPS7 -0.261179092929062 0.744019631321393 0.578407496374309 0.364461275867134 miRNAWalker2_validate -0.200438582236913 1.33310685962625e-05 NA NA NA hsa-miR-107 RPSA -0.289737369453023 0.769655185893943 0.292708372647978 0.663661434401365 miRNAWalker2_validate -0.135692015405418 0.0193898204881825 NA NA NA hsa-miR-22-3p RPSA 0.0468440219945929 0.967778504781139 0.292708372647978 0.663661434401365 miRNAWalker2_validate -0.197954807985867 6.81912112983427e-06 NA NA NA hsa-miR-320c RRAGA 0.092255964601645 0.785539881268253 0.0819297751546291 0.888635624940392 miRanda -0.110555970794377 0.00015225890556914 NA NA NA hsa-let-7a-5p RRM2 0.0514604984725615 0.971564723582327 0.091558583573625 0.860013237170084 miRNAWalker2_validate;TargetScan;miRNATAP -0.163436063943835 0.0196433928946487 NA NA NA hsa-let-7b-5p RRM2 0.396604576702067 0.783406687058469 0.091558583573625 0.860013237170084 miRNAWalker2_validate;miRNATAP -0.153545035006454 0.00521383902113034 NA NA NA hsa-let-7g-5p RRM2 -0.320647530232065 0.660364346555039 0.091558583573625 0.860013237170084 miRNAWalker2_validate;miRNATAP -0.128817817183462 0.0301696422963688 NA NA NA hsa-miR-100-5p RRM2 0.0542447471759004 0.961097766133859 0.091558583573625 0.860013237170084 miRNAWalker2_validate -0.187022897653427 1.4985349782967e-05 NA NA NA hsa-miR-125a-5p RRM2 -0.00666761469427968 0.994891296705929 0.091558583573625 0.860013237170084 miRanda -0.576207272259753 3.21524575955887e-10 NA NA NA hsa-miR-26a-5p RRM2 0.0483232931294246 0.955218190818435 0.091558583573625 0.860013237170084 miRNAWalker2_validate -0.360380428076598 1.11047607712885e-06 NA NA NA hsa-miR-30c-5p RRM2 -0.183013966936985 0.833177718550926 0.091558583573625 0.860013237170084 miRNAWalker2_validate -0.153834745041282 0.0231865842350266 NA NA NA hsa-miR-15b-5p RSBN1 0.251826642099145 0.790709218602499 -0.154708510116565 0.73194302907544 MirTarget;miRNATAP -0.146546310493701 3.97248127361801e-05 NA NA NA hsa-miR-22-3p RSBN1 0.0468440219945929 0.967778504781139 -0.154708510116565 0.73194302907544 MirTarget;miRNATAP -0.166822654456481 1.21040636980985e-10 NA NA NA hsa-miR-107 RSL24D1 -0.289737369453023 0.769655185893943 0.46030178817281 0.400820405815939 miRanda -0.135994745699676 0.00386690832018473 NA NA NA hsa-miR-221-3p RUNDC3B -0.261179092929062 0.744019631321393 -0.0739775551039484 0.797144274795367 miRNAWalker2_validate -0.184187848351778 0.00549722355295424 NA NA NA hsa-miR-148a-3p RUNX1T1 -0.324144803192141 0.746264759480212 0.368230121873391 0.426434278656151 miRNATAP -0.26896168971416 0.0143322359174856 NA NA NA hsa-miR-129-5p S100A2 0.417083435812871 0.454236109516901 0.261143473678285 0.656697976549966 miRanda -0.154696698860132 0.0318418334086274 NA NA NA hsa-miR-15b-5p SALL1 0.251826642099145 0.790709218602499 0.280191846617212 0.657573081603446 MirTarget;miRNATAP -0.699291401488615 0.000332246297685377 NA NA NA hsa-miR-107 SALL4 -0.289737369453023 0.769655185893943 -0.510631590858331 0.266073078661525 PITA;miRanda;miRNATAP -0.343825619948558 0.0103877110710336 NA NA NA hsa-miR-150-5p SAMD5 -0.00683324482969283 0.994067057151257 0.172708926466839 0.592027749121823 mirMAP -0.114824758863637 0.0101685236665009 NA NA NA hsa-miR-146b-5p SATB1 0.0340352805627226 0.964565988329585 0.165449390770036 0.721121560773717 miRanda -0.183596380405131 0.00244006964033897 NA NA NA hsa-miR-155-5p SATB1 -0.320577372003167 0.673183036961734 0.165449390770036 0.721121560773717 MirTarget;miRNATAP -0.216253327964336 0.000294169417117306 NA NA NA hsa-miR-15b-3p SATB1 0.0805005446828257 0.846317514546419 0.165449390770036 0.721121560773717 mirMAP -0.202471246524581 0.00767866886770009 NA NA NA hsa-miR-186-5p SATB1 -0.246324984406451 0.701310703524093 0.165449390770036 0.721121560773717 MirTarget;mirMAP;miRNATAP -0.337497986139765 0.000504734394223797 NA NA NA hsa-miR-191-5p SATB1 -0.0380336320236179 0.966298816437394 0.165449390770036 0.721121560773717 miRNAWalker2_validate;miRTarBase;MirTarget -0.266403846276284 0.00594017230353823 23542418 miR-191 and SATB1 show inverse correlation of expression breast cancer hsa-miR-362-5p SATB1 -0.35564884735017 0.452162806620853 0.165449390770036 0.721121560773717 PITA;miRNATAP -0.137192138627672 0.0117915148534768 NA NA NA hsa-miR-501-3p SATB1 0.272254003876544 0.713437785858009 0.165449390770036 0.721121560773717 miRNATAP -0.137167367014234 0.0149525692507395 NA NA NA hsa-miR-501-5p SATB1 -0.277968789063541 0.510742720785555 0.165449390770036 0.721121560773717 miRNATAP -0.201116741199343 0.000764059475534752 NA NA NA hsa-miR-15b-5p SATB2 0.251826642099145 0.790709218602499 -0.663000165483578 0.0472334757509491 miRNATAP -0.205949463003812 0.0431697329847094 NA NA NA hsa-miR-139-5p SBK1 -0.0625698939687087 0.914810329989088 -0.514426451142808 0.304097974116027 PITA;miRanda -0.175897641147563 0.00937779007539073 NA NA NA hsa-miR-221-3p SBK1 -0.261179092929062 0.744019631321393 -0.514426451142808 0.304097974116027 miRNATAP -0.343471682742135 7.82999130410168e-08 NA NA NA hsa-miR-222-3p SBK1 -0.233673471709747 0.726651775432807 -0.514426451142808 0.304097974116027 miRNATAP -0.29488321044041 3.87630150530919e-06 NA NA NA hsa-miR-107 SCAMP5 -0.289737369453023 0.769655185893943 0.270420817325495 0.534796171317991 MirTarget;PITA;miRNATAP -0.122206761484449 0.0440745701087857 NA NA NA hsa-miR-18a-3p SCARA3 -0.188202012159778 0.618004963641688 0.398699618021529 0.594925768389964 MirTarget -0.33761417530034 1.89656827108387e-05 NA NA NA hsa-miR-429 SCARA3 -0.596617415946644 0.128967410286089 0.398699618021529 0.594925768389964 miRNATAP -0.141562102901069 0.0218339878080745 NA NA NA hsa-miR-615-3p SCARA3 0.286701660819175 0.572732067119559 0.398699618021529 0.594925768389964 miRNAWalker2_validate -0.138089379955177 0.00558374587360991 NA NA NA hsa-miR-107 SCHIP1 -0.289737369453023 0.769655185893943 0.373312951254524 0.314200418398264 miRanda -0.162482417546162 0.0155282138733367 NA NA NA hsa-miR-98-5p SCHIP1 -0.0484028619275874 0.910781316485549 0.373312951254524 0.314200418398264 miRNAWalker2_validate -0.126260270328295 0.00440776620029997 NA NA NA hsa-miR-221-3p SCN11A -0.261179092929062 0.744019631321393 -0.105497784722535 0.815957407872485 MirTarget -0.287356526000901 0.00324532397569311 NA NA NA hsa-miR-222-3p SCN11A -0.233673471709747 0.726651775432807 -0.105497784722535 0.815957407872485 MirTarget -0.30957807405111 0.0013716528281449 NA NA NA hsa-miR-660-5p SCN2A -0.561687438133488 0.138270972367544 0.388866325627938 0.447580543628337 MirTarget -0.219378613237614 0.0199114090632024 NA NA NA hsa-miR-107 SCN7A -0.289737369453023 0.769655185893943 0.292265359386536 0.598616017397583 miRanda -0.358554960135577 0.0268402622719493 NA NA NA hsa-miR-766-3p SCRIB 0.103832486444169 0.839257506039953 -0.220989042575043 0.75376002502372 miRNAWalker2_validate -0.102115006020576 0.0134573895008186 NA NA NA hsa-miR-9-5p SCRIB 0.029299723902132 0.964227616086639 -0.220989042575043 0.75376002502372 MirTarget;miRNATAP -0.123290160512352 1.98195793711299e-07 NA NA NA hsa-miR-141-3p SCUBE2 -0.36932301319088 0.428364456128406 0.363956640401652 0.378951294001416 MirTarget -0.203339815861216 0.0278623175937236 NA NA NA hsa-miR-146b-5p SCUBE2 0.0340352805627226 0.964565988329585 0.363956640401652 0.378951294001416 miRanda -0.178692070594521 0.0182647338739054 NA NA NA hsa-miR-335-3p SCUBE2 0.0738544228922926 0.89349398283313 0.363956640401652 0.378951294001416 mirMAP -0.212827352651439 0.00331377786413549 NA NA NA hsa-miR-576-5p SCUBE2 -0.521065838204864 0.11793493718786 0.363956640401652 0.378951294001416 miRNATAP -0.236429317588068 0.0043033133631298 NA NA NA hsa-miR-9-5p SCUBE2 0.029299723902132 0.964227616086639 0.363956640401652 0.378951294001416 MirTarget -0.122909449658245 0.014846102349032 NA NA NA hsa-miR-98-5p SCUBE3 -0.0484028619275874 0.910781316485549 -0.353187464237361 0.500293845388761 mirMAP -0.345629978389189 0.000591788621314637 NA NA NA hsa-miR-22-3p SCYL3 0.0468440219945929 0.967778504781139 0.0612511438713583 0.869363850106949 MirTarget -0.10725537783532 1.54861884640002e-06 NA NA NA hsa-miR-27a-3p SDC2 0.309634509674364 0.703724209648479 0.505229029676173 0.355989708133649 miRNATAP -0.218488005426786 0.00298953878296376 NA NA NA hsa-miR-140-3p SDC4 -0.105651799466207 0.9077781740714 0.091589978224178 0.901144306719051 MirTarget -0.105542930502948 0.0431689061844167 NA NA NA hsa-miR-15b-5p SEC14L5 0.251826642099145 0.790709218602499 0.0448946605966545 0.90662873124006 mirMAP -0.307043887184664 0.00813943155982171 NA NA NA hsa-miR-92a-3p SEC24C 0.0155161307487504 0.991444817308063 -0.0271588399316052 0.965726751708944 miRNATAP -0.116626522580052 0.000872152812171472 NA NA NA hsa-miR-148a-3p SEMA5A -0.324144803192141 0.746264759480212 0.129982216863797 0.797651199757957 mirMAP -0.17724687031974 0.03829415475493 NA NA NA hsa-miR-660-5p SEMA5A -0.561687438133488 0.138270972367544 0.129982216863797 0.797651199757957 mirMAP -0.160110721195906 0.0175277855429866 NA NA NA hsa-miR-107 SEMA6A -0.289737369453023 0.769655185893943 -0.0388807728352623 0.931906595268609 MirTarget;PITA;miRanda;miRNATAP -0.299426126642775 0.00532498934342631 NA NA NA hsa-miR-15b-5p SEMA6A 0.251826642099145 0.790709218602499 -0.0388807728352623 0.931906595268609 miRNATAP -0.448166714888371 4.88592298989109e-05 NA NA NA hsa-miR-27a-3p SEMA6A 0.309634509674364 0.703724209648479 -0.0388807728352623 0.931906595268609 MirTarget;miRNATAP -0.3793828624656 4.53650156920796e-05 NA NA NA hsa-miR-27a-3p SEMA6D 0.309634509674364 0.703724209648479 0.26918388256722 0.545190021393729 mirMAP;miRNATAP -0.147175994596083 0.0438730290467612 NA NA NA hsa-miR-15b-5p SEMA7A 0.251826642099145 0.790709218602499 -0.0979445084521475 0.780913223971977 mirMAP -0.169783837674787 0.00865276542485129 NA NA NA hsa-miR-140-3p SENP2 -0.105651799466207 0.9077781740714 0.015835816529953 0.974849266008929 mirMAP -0.109397083290457 0.00110439552384191 NA NA NA hsa-miR-22-3p SEPHS1 0.0468440219945929 0.967778504781139 0.0662487242888234 0.904108420401142 MirTarget;miRNATAP -0.111041371404203 0.00126639968327824 NA NA NA hsa-miR-221-3p SEPHS1 -0.261179092929062 0.744019631321393 0.0662487242888234 0.904108420401142 miRNAWalker2_validate -0.20653118983443 2.16495266020015e-09 NA NA NA hsa-miR-139-5p SEPT3 -0.0625698939687087 0.914810329989088 0.0873690218339673 0.816851401663324 PITA;miRanda -0.143023717794118 0.0464294747776771 NA NA NA hsa-miR-107 SEPT5 -0.289737369453023 0.769655185893943 -0.65077366406282 0.149174549959677 miRNATAP -0.177872888769527 0.028605405819385 NA NA NA hsa-miR-330-5p SERPINA6 -0.152605584680815 0.787259112745893 -0.157530538095705 0.834584591072215 miRanda -0.416130703270751 0.0136434077969571 NA NA NA hsa-miR-107 SERPINB5 -0.289737369453023 0.769655185893943 -0.226978629000397 0.719507712167247 MirTarget;miRanda -0.411085302764306 0.0307173007689843 NA NA NA hsa-miR-26b-5p SERPINH1 0.16143906971203 0.790777916193478 -0.14961240611572 0.844804477179248 miRNAWalker2_validate -0.187516096547147 0.000301993914550241 NA NA NA hsa-miR-29a-3p SERPINH1 0.203872357562561 0.859946061784007 -0.14961240611572 0.844804477179248 miRNATAP -0.184417897599364 1.25037185016305e-06 27488440 Regulation of LOXL2 and SERPINH1 by antitumor microRNA 29a in lung cancer with idiopathic pulmonary fibrosis; Downregulation of miR-29a caused overexpression of LOXL2 and SERPINH1 in lung cancer and IPF suggesting that these genes are involved in the pathogenesis of these two diseases.Journal of Human Genetics advance online publication 4 August 2016; doi:10.1038/jhg.2016.99 staging lung cancer hsa-miR-29c-3p SERPINH1 0.042533372292219 0.941334605544826 -0.14961240611572 0.844804477179248 miRNATAP -0.140333951192061 6.26555655914327e-06 NA NA NA hsa-miR-15b-5p SESN1 0.251826642099145 0.790709218602499 0.218778816354514 0.568533794057563 MirTarget;miRNATAP -0.228920802180496 6.49709200314064e-07 NA NA NA hsa-miR-16-5p SESN1 -0.199225750365017 0.742834324195084 0.218778816354514 0.568533794057563 MirTarget;miRNATAP -0.188490703208021 6.89825512148969e-07 NA NA NA hsa-miR-21-5p SESN1 -0.515762857245393 0.64198914412298 0.218778816354514 0.568533794057563 miRNAWalker2_validate -0.117781852750738 6.32618397283612e-06 NA NA NA hsa-miR-22-3p SESN1 0.0468440219945929 0.967778504781139 0.218778816354514 0.568533794057563 MirTarget -0.169381889173291 6.98725445868371e-07 NA NA NA hsa-miR-24-3p SESN1 0.0408517902063537 0.966828370841971 0.218778816354514 0.568533794057563 miRNAWalker2_validate;MirTarget;miRNATAP -0.1870247250319 2.92576970036472e-05 NA NA NA hsa-miR-28-5p SESN1 -0.0511712157419266 0.910958192291954 0.218778816354514 0.568533794057563 PITA;miRanda;miRNATAP -0.172633146058176 0.000183878359564318 NA NA NA hsa-miR-502-3p SESN1 -0.161049433579914 0.724644527567453 0.218778816354514 0.568533794057563 MirTarget;miRNATAP -0.124246019711628 0.000845239197090294 NA NA NA hsa-miR-148a-3p SESTD1 -0.324144803192141 0.746264759480212 -0.365825887576899 0.409803832964815 miRNAWalker2_validate;MirTarget;miRNATAP -0.141145665836456 0.0213338260591289 NA NA NA hsa-miR-98-5p SESTD1 -0.0484028619275874 0.910781316485549 -0.365825887576899 0.409803832964815 MirTarget -0.195820340381351 0.00011114093941838 NA NA NA hsa-miR-362-5p SETBP1 -0.35564884735017 0.452162806620853 -0.0838270778415597 0.847078737131474 miRNATAP -0.195665252774334 2.22501252613661e-05 NA NA NA hsa-miR-181a-5p SFMBT1 -0.0320774839604816 0.975806098950371 0.0236708878400513 0.953427476873761 MirTarget;miRNATAP -0.154345554885015 0.00134555823207998 NA NA NA hsa-miR-181b-5p SFMBT1 -0.0483087651223055 0.952929800264921 0.0236708878400513 0.953427476873761 MirTarget;miRNATAP -0.134094678164363 0.00395115757725241 NA NA NA hsa-miR-146b-5p SFRP1 0.0340352805627226 0.964565988329585 0.249499069395879 0.676671825793369 MirTarget -0.234220384064632 0.0185593183931207 NA NA NA hsa-miR-182-5p SFRP1 -0.262297863136789 0.8110070165759 0.249499069395879 0.676671825793369 mirMAP -0.266706586234969 0.00129242881271931 NA NA NA hsa-miR-27a-3p SFRP1 0.309634509674364 0.703724209648479 0.249499069395879 0.676671825793369 MirTarget;miRNATAP -0.330149862048713 0.012208271649274 NA NA NA hsa-miR-625-5p SFRP1 -0.725005787172203 0.0605502864822602 0.249499069395879 0.676671825793369 MirTarget -0.312728688961055 0.000253628865181897 NA NA NA hsa-miR-129-5p SFRP4 0.417083435812871 0.454236109516901 0.666557255105399 0.332894023704605 miRanda -0.361172539288748 4.34067056391917e-06 NA NA NA hsa-miR-34c-3p SFRP4 0.406037381073938 0.485206005408757 0.666557255105399 0.332894023704605 miRNATAP -0.201091379352469 0.00188078337411422 NA NA NA hsa-miR-375 SFRP4 -0.989394125724925 0.312728638150002 0.666557255105399 0.332894023704605 miRanda -0.306668550693032 1.66132365516052e-07 NA NA NA hsa-miR-15b-5p SFT2D3 0.251826642099145 0.790709218602499 0.209180235218954 0.626753176552513 MirTarget -0.105008199153152 0.0117689831932862 NA NA NA hsa-miR-23a-3p SFXN1 0.174045248211037 0.865717934161724 -0.0364628456579812 0.936457643082513 mirMAP -0.128277980227136 0.00186414602020985 NA NA NA hsa-miR-26a-5p SFXN1 0.0483232931294246 0.955218190818435 -0.0364628456579812 0.936457643082513 MirTarget -0.17533630088536 9.55771978730793e-05 NA NA NA hsa-miR-26b-5p SFXN1 0.16143906971203 0.790777916193478 -0.0364628456579812 0.936457643082513 MirTarget -0.119145103876869 0.00810025810711398 NA NA NA hsa-miR-28-5p SFXN1 -0.0511712157419266 0.910958192291954 -0.0364628456579812 0.936457643082513 miRanda -0.103998023470172 0.0141785741552916 NA NA NA hsa-miR-30c-1-3p SFXN1 0.140640717600046 0.633563796650597 -0.0364628456579812 0.936457643082513 MirTarget -0.135711941289367 5.0048772176584e-05 NA NA NA hsa-miR-15b-5p SGCD 0.251826642099145 0.790709218602499 0.588963498793269 0.197618855406376 miRNATAP -0.270797846270193 0.0161421166898019 NA NA NA hsa-miR-150-5p SH2D5 -0.00683324482969283 0.994067057151257 -0.679029740750115 0.0691880987937774 mirMAP -0.136817568070378 0.00505086222974839 NA NA NA hsa-miR-15b-5p SH3BGRL2 0.251826642099145 0.790709218602499 0.0934765080598625 0.844116989544164 miRNATAP -0.283373009087527 7.15881795284859e-05 NA NA NA hsa-miR-27a-3p SH3BGRL2 0.309634509674364 0.703724209648479 0.0934765080598625 0.844116989544164 miRNATAP -0.288645333629101 1.37161433016012e-06 NA NA NA hsa-miR-107 SH3GL2 -0.289737369453023 0.769655185893943 -0.174297188659928 0.776655663692274 PITA;miRanda;miRNATAP -0.377380585548352 0.0291766653158415 NA NA NA hsa-miR-107 SH3PXD2A -0.289737369453023 0.769655185893943 0.275906232442527 0.638094470813096 PITA;mirMAP -0.135215113057022 0.041349387689217 NA NA NA hsa-miR-200c-3p SHCBP1 -0.333638625701646 0.813830738880144 0.0376615951028567 0.911453688589757 MirTarget;miRNATAP -0.127342124694961 0.00186446395092925 NA NA NA hsa-miR-320c SHCBP1 0.092255964601645 0.785539881268253 0.0376615951028567 0.911453688589757 MirTarget;miRanda;miRNATAP -0.191468082094983 1.72737903787397e-05 NA NA NA hsa-miR-320d SHCBP1 0.353471568894745 0.357430999251147 0.0376615951028567 0.911453688589757 MirTarget;miRanda;miRNATAP -0.116510026393302 0.00089305620151459 NA NA NA hsa-miR-92a-3p SHCBP1 0.0155161307487504 0.991444817308063 0.0376615951028567 0.911453688589757 miRNATAP -0.180189227339463 0.00435968181743681 NA NA NA hsa-miR-27a-3p SHE 0.309634509674364 0.703724209648479 -0.229976916108664 0.39750503056915 MirTarget -0.12907964260342 0.0282717117337328 NA NA NA hsa-miR-150-5p SHH -0.00683324482969283 0.994067057151257 -1.23033150413094 0.0914303555498377 mirMAP -0.393491733771372 1.23922727527381e-05 NA NA NA hsa-let-7a-5p SHMT2 0.0514604984725615 0.971564723582327 0.00802704593182391 0.989371262911232 miRNAWalker2_validate -0.163183197414169 0.00121017568291772 NA NA NA hsa-miR-15b-5p SHROOM4 0.251826642099145 0.790709218602499 0.00808181304420419 0.984208399410339 miRNATAP -0.236331266130922 0.00210427111516721 NA NA NA hsa-miR-15b-5p SIAH1 0.251826642099145 0.790709218602499 0.108977383960605 0.813939321510207 miRNATAP -0.115044616438337 0.00204983347244596 NA NA NA hsa-miR-15b-5p SIDT2 0.251826642099145 0.790709218602499 0.231119593783537 0.67853077394684 miRNATAP -0.115535966962663 0.0143820904958486 NA NA NA hsa-miR-15b-5p SIPA1L2 0.251826642099145 0.790709218602499 0.0228264886885707 0.960734606692957 miRNATAP -0.195013360670696 0.0046928320228576 NA NA NA hsa-miR-15b-5p SIRT4 0.251826642099145 0.790709218602499 0.068755968003246 0.744728329557899 MirTarget -0.200381127063114 0.00127538234131501 NA NA NA hsa-miR-139-5p SIX4 -0.0625698939687087 0.914810329989088 0.00601229681179927 0.990165128399768 miRanda -0.152655501688566 0.000968391472211355 NA NA NA hsa-miR-148a-3p SIX4 -0.324144803192141 0.746264759480212 0.00601229681179927 0.990165128399768 miRNATAP -0.130049114822075 0.00392468331548636 NA NA NA hsa-miR-107 SIX5 -0.289737369453023 0.769655185893943 -0.0895234366406772 0.868967733447291 mirMAP -0.168529103729667 0.000130277277622181 NA NA NA hsa-miR-140-3p SLC10A4 -0.105651799466207 0.9077781740714 -0.646793378078498 0.173404879141603 miRNATAP -0.266458071984974 0.0357202027906586 NA NA NA hsa-miR-129-5p SLC12A8 0.417083435812871 0.454236109516901 0.0825595413140618 0.8607560058089 miRanda -0.112884356119527 0.00121549332243004 NA NA NA hsa-miR-15b-5p SLC13A3 0.251826642099145 0.790709218602499 0.552922073271358 0.160240189445075 miRNATAP -0.288942470216505 0.00665506246594627 NA NA NA hsa-miR-150-5p SLC16A12 -0.00683324482969283 0.994067057151257 0.154442523868255 0.792553606510747 MirTarget -0.444298716176835 5.90013159190239e-09 NA NA NA hsa-miR-140-3p SLC19A1 -0.105651799466207 0.9077781740714 -0.171141947376898 0.656532222592474 mirMAP -0.105599120780875 0.017046027820587 NA NA NA hsa-miR-150-5p SLC22A23 -0.00683324482969283 0.994067057151257 -0.432800962975415 0.382375583304495 mirMAP -0.105592763812875 0.00244713540103495 NA NA NA hsa-miR-125a-3p SLC22A5 0.124026360619668 0.800539414590835 -0.132924390957716 0.728628736123748 miRanda -0.191420397460061 0.000427697464303539 NA NA NA hsa-miR-342-3p SLC22A5 -0.233020179388453 0.739959578456401 -0.132924390957716 0.728628736123748 miRanda -0.164785692651775 0.000338748072572807 NA NA NA hsa-miR-130b-3p SLC24A3 -0.246958204594817 0.524070870130445 0.0367578059707006 0.936597613957823 MirTarget;miRNATAP -0.222901692435812 0.0211641540144617 NA NA NA hsa-miR-184 SLC24A3 -0.348262337174389 0.472209661668959 0.0367578059707006 0.936597613957823 miRanda -0.127868176857544 0.0192663730902977 NA NA NA hsa-miR-25-3p SLC24A3 0.0681841609869576 0.955267320175687 0.0367578059707006 0.936597613957823 MirTarget;miRNATAP -0.374839343533182 0.00336877750080666 NA NA NA hsa-miR-92a-3p SLC24A3 0.0155161307487504 0.991444817308063 0.0367578059707006 0.936597613957823 MirTarget;miRNATAP -0.375674768920959 0.00208911479566789 NA NA NA hsa-miR-15b-5p SLC25A26 0.251826642099145 0.790709218602499 0.114732886743223 0.757371443225099 mirMAP -0.102050468300629 0.00406894035131048 NA NA NA hsa-miR-25-3p SLC25A32 0.0681841609869576 0.955267320175687 0.199609365268087 0.662906742045897 MirTarget -0.100754017873342 0.0243072243285109 NA NA NA hsa-miR-197-3p SLC25A37 0.0240027695773914 0.981971058073739 -0.220719360527248 0.605051373219336 mirMAP -0.135303649271352 0.0137036896787542 NA NA NA hsa-miR-30e-3p SLC27A6 0.202355073367528 0.857417040078429 0.412799646381101 0.40867301173963 MirTarget -0.438669582232791 0.00204207689177952 NA NA NA hsa-miR-320a SLC2A1 0.142884703798297 0.888511174254355 -0.263261997909346 0.732768866252264 miRNAWalker2_validate -0.131339019144939 0.0334109074209598 NA NA NA hsa-miR-361-5p SLC2A1 -0.278147578656315 0.728553069590798 -0.263261997909346 0.732768866252264 miRanda -0.190032125886129 0.0288605571033337 NA NA NA hsa-miR-92a-1-5p SLC2A1 -0.0244017451020895 0.958247318021666 -0.263261997909346 0.732768866252264 MirTarget -0.13214395258067 0.0170865761489152 NA NA NA hsa-miR-27a-3p SLC35F1 0.309634509674364 0.703724209648479 0.110539220111251 0.806830378007067 miRNATAP -0.256633640208991 0.0239565822660091 NA NA NA hsa-miR-660-5p SLC35F1 -0.561687438133488 0.138270972367544 0.110539220111251 0.806830378007067 miRNATAP -0.383047643628933 1.88270780436249e-06 NA NA NA hsa-miR-22-3p SLC39A10 0.0468440219945929 0.967778504781139 -0.0324057610934929 0.951393362723483 miRNATAP -0.185979454436773 4.48512311416522e-06 NA NA NA hsa-miR-107 SLC40A1 -0.289737369453023 0.769655185893943 0.13984560920229 0.844826272653304 miRanda -0.189405016332322 0.0388761579871402 NA NA NA hsa-miR-197-3p SLC45A4 0.0240027695773914 0.981971058073739 -0.307908912393824 0.590897732601942 mirMAP -0.197333861777358 0.00108499463313865 NA NA NA hsa-miR-106b-5p SLC46A3 -0.3941595235172 0.389635342155994 0.0706140114033746 0.858032150135078 MirTarget -0.239240820771262 5.27549454063488e-05 NA NA NA hsa-miR-125b-5p SLC46A3 0.0074438975183444 0.994154663318355 0.0706140114033746 0.858032150135078 MirTarget -0.144035600201226 0.00480325775083521 NA NA NA hsa-miR-93-5p SLC46A3 -0.375078982324499 0.732311284477601 0.0706140114033746 0.858032150135078 MirTarget -0.150645495055906 0.00801093993531568 NA NA NA hsa-miR-197-3p SLC47A2 0.0240027695773914 0.981971058073739 -0.271594435525068 0.57329213826486 MirTarget -0.367203593683702 0.0125923408539733 NA NA NA hsa-miR-15b-5p SLC4A4 0.251826642099145 0.790709218602499 0.145859114640415 0.707510198586525 MirTarget;miRNATAP -0.257948932009098 0.0236254065320699 NA NA NA hsa-let-7a-5p SLC5A6 0.0514604984725615 0.971564723582327 0.0494947732315039 0.923872781583892 MirTarget;TargetScan;miRNATAP -0.251042059777219 2.24399650030648e-08 NA NA NA hsa-let-7b-5p SLC5A6 0.396604576702067 0.783406687058469 0.0494947732315039 0.923872781583892 MirTarget;miRNATAP -0.265393346735905 1.37283542230472e-14 NA NA NA hsa-let-7d-5p SLC5A6 0.0119393569456978 0.988390093874148 0.0494947732315039 0.923872781583892 MirTarget;miRNATAP -0.18740094750931 5.50133751388111e-06 NA NA NA hsa-let-7i-5p SLC5A6 -0.0940710536612883 0.902310710205355 0.0494947732315039 0.923872781583892 MirTarget;miRNATAP -0.139129847207401 0.000524356120467473 NA NA NA hsa-miR-27b-3p SLC5A6 0.306246927737414 0.735781270461428 0.0494947732315039 0.923872781583892 miRNAWalker2_validate -0.186380482741523 6.46006960212315e-06 NA NA NA hsa-miR-381-3p SLC7A11 0.269633663970002 0.562625029053898 -0.546192374168312 0.213498746002808 mirMAP -0.1435319879994 0.020228120110276 NA NA NA hsa-miR-214-3p SLC7A8 0.0312810611346688 0.952640488671912 0.115091409221363 0.841294243198694 miRNATAP -0.110805162804914 0.00402397622847998 NA NA NA hsa-miR-150-5p SLIT1 -0.00683324482969283 0.994067057151257 0.0610725093475897 0.907592153215612 mirMAP -0.25203985208806 0.000564180296071805 NA NA NA hsa-miR-107 SMAD6 -0.289737369453023 0.769655185893943 0.117020356196165 0.809104774559833 miRanda -0.134392470850536 0.0368618356060279 NA NA NA hsa-miR-27a-3p SMAD9 0.309634509674364 0.703724209648479 -0.225911828351078 0.494493897259927 MirTarget;miRNATAP -0.229182337833288 0.00703318324976007 NA NA NA hsa-miR-128-3p SMARCA2 -0.0364518492233463 0.95841670253784 0.0232780724218085 0.9677385044186 MirTarget -0.214045802403316 0.00264051945962438 NA NA NA hsa-miR-222-3p SMARCA4 -0.233673471709747 0.726651775432807 0.00432489768303235 0.995035116273072 miRNAWalker2_validate -0.123378086106077 0.00405403775730298 NA NA NA hsa-miR-26b-5p SMC4 0.16143906971203 0.790777916193478 0.0484144852497836 0.938428931312027 miRNAWalker2_validate -0.164664624039331 0.00239760613842214 NA NA NA hsa-miR-222-3p SMC6 -0.233673471709747 0.726651775432807 0.218230951901899 0.616398369548422 miRNAWalker2_validate -0.104745480873173 0.000506276502630655 NA NA NA hsa-miR-152-3p SMS -0.00518835781888161 0.99248323637383 -0.00794890633420753 0.987990283140157 MirTarget -0.130068619197713 0.000133540462270428 NA NA NA hsa-miR-23a-3p SMS 0.174045248211037 0.865717934161724 -0.00794890633420753 0.987990283140157 MirTarget -0.138736675342903 0.00335107430370668 NA NA NA hsa-miR-107 SNAI2 -0.289737369453023 0.769655185893943 0.500941280008221 0.27786604895158 miRanda -0.234207164786582 0.0202107019219599 NA NA NA hsa-miR-155-5p SNED1 -0.320577372003167 0.673183036961734 -0.257153399914458 0.579866365351384 mirMAP -0.168908444040065 0.00138533743240903 NA NA NA hsa-miR-9-5p SNED1 0.029299723902132 0.964227616086639 -0.257153399914458 0.579866365351384 mirMAP -0.125888145233599 0.000393726486407513 NA NA NA hsa-miR-27a-3p SNN 0.309634509674364 0.703724209648479 -0.0541629523540132 0.908074694474143 miRNATAP -0.162493902087489 0.00150034720490445 NA NA NA hsa-miR-107 SNX18 -0.289737369453023 0.769655185893943 0.212273590968778 0.656791971001171 miRanda;miRNATAP -0.123201299549421 0.00227407495099492 NA NA NA hsa-miR-15b-5p SNX21 0.251826642099145 0.790709218602499 0.0850409386386737 0.83041161190719 mirMAP -0.105204418741291 0.00530716037214823 NA NA NA hsa-miR-222-3p SNX4 -0.233673471709747 0.726651775432807 -0.078369830421142 0.872238532699247 MirTarget -0.118201507605213 1.54335503592314e-06 NA NA NA hsa-miR-107 SOCS2 -0.289737369453023 0.769655185893943 -0.505615702767771 0.0806726513396641 miRanda -0.155192919970033 0.0343051880321477 NA NA NA hsa-miR-324-5p SOCS2 -0.358991607952497 0.499732551112182 -0.505615702767771 0.0806726513396641 miRanda -0.205636201991699 0.0014074017773986 NA NA NA hsa-miR-940 SOCS2 0.19340062942074 0.679749292292113 -0.505615702767771 0.0806726513396641 miRNATAP -0.103458680193388 0.0282292360296185 NA NA NA hsa-miR-296-3p SOD3 0.305371903227786 0.470342914513253 0.695296230382932 0.203009553367131 miRanda -0.174236233254736 0.00602606372565523 NA NA NA hsa-miR-17-5p SORL1 -0.643066792834501 0.320674049526638 0.485565558483718 0.507215732758671 MirTarget;TargetScan;miRNATAP -0.152196890626584 0.0104711243927287 NA NA NA hsa-miR-18a-3p SORL1 -0.188202012159778 0.618004963641688 0.485565558483718 0.507215732758671 MirTarget -0.177913192814271 0.00681887478177459 NA NA NA hsa-miR-148a-3p SOX11 -0.324144803192141 0.746264759480212 0.942365499639792 0.261560242434896 miRNATAP -0.800415000936596 5.74365372493216e-05 NA NA NA hsa-miR-27a-3p SOX11 0.309634509674364 0.703724209648479 0.942365499639792 0.261560242434896 miRNATAP -0.497201689220818 0.0242529620573791 NA NA NA hsa-miR-140-3p SOX12 -0.105651799466207 0.9077781740714 -0.0690861748878868 0.913116184656001 MirTarget;PITA;miRNATAP -0.148208041918136 0.00414541063057905 NA NA NA hsa-miR-214-3p SOX12 0.0312810611346688 0.952640488671912 -0.0690861748878868 0.913116184656001 mirMAP -0.11648339483912 0.000110929771771017 NA NA NA hsa-miR-22-3p SOX13 0.0468440219945929 0.967778504781139 0.0392133635488072 0.9463522475342 MirTarget -0.136850954214571 0.00107632006108242 NA NA NA hsa-miR-98-5p SOX4 -0.0484028619275874 0.910781316485549 -0.307226323554338 0.652796780458641 miRNAWalker2_validate -0.171401781306128 1.13321269428639e-05 NA NA NA hsa-miR-15b-5p SOX6 0.251826642099145 0.790709218602499 -0.346434606181844 0.458702400007528 MirTarget;miRNATAP -0.481168702526696 4.22755629587749e-05 NA NA NA hsa-miR-27a-3p SP6 0.309634509674364 0.703724209648479 0.189165611967267 0.633896782786699 miRNATAP -0.19978195438846 0.0351698090173476 NA NA NA hsa-miR-221-3p SPAG5 -0.261179092929062 0.744019631321393 -0.361656167257142 0.430121201430481 miRNAWalker2_validate -0.159527825312009 0.0013493892585423 NA NA NA hsa-miR-15b-5p SPAG7 0.251826642099145 0.790709218602499 0.0591761076466382 0.895555864769221 miRNATAP -0.131896551828949 0.000293813121545473 NA NA NA hsa-miR-139-5p SPATA17 -0.0625698939687087 0.914810329989088 0.00857720041780152 0.981227541971725 miRanda -0.228687536162075 0.00680091668391328 NA NA NA hsa-miR-139-5p SPATA5L1 -0.0625698939687087 0.914810329989088 0.148928093509348 0.652222100862292 miRanda -0.10418493844943 0.0018753441879598 NA NA NA hsa-miR-1275 SPC25 0.524790554828265 0.301913533762167 -0.107843818876329 0.77393657637671 MirTarget -0.11584800134516 0.00127245595979118 NA NA NA hsa-miR-26b-5p SPC25 0.16143906971203 0.790777916193478 -0.107843818876329 0.77393657637671 miRNAWalker2_validate -0.23166023713431 0.00270526199783527 NA NA NA hsa-miR-15b-5p SPHK2 0.251826642099145 0.790709218602499 -0.00196005164537461 0.996451472089075 mirMAP -0.145973908724666 0.000880039844800107 NA NA NA hsa-miR-1226-3p SPOCK2 -0.0434800785654232 0.94274999489083 0.213690959195921 0.790735070893123 mirMAP -0.234151091658458 0.00415050203912642 NA NA NA hsa-miR-339-5p SPOCK2 -0.121565674268033 0.81427862647099 0.213690959195921 0.790735070893123 mirMAP -0.243940554166458 0.0235231741296718 NA NA NA hsa-miR-766-3p SPOCK2 0.103832486444169 0.839257506039953 0.213690959195921 0.790735070893123 mirMAP -0.232759667456781 0.0123552701480085 NA NA NA hsa-miR-877-3p SPOCK2 -0.228887480748248 0.565006251347097 0.213690959195921 0.790735070893123 mirMAP -0.229430950998045 0.00158337231491546 NA NA NA hsa-miR-9-5p SPOCK2 0.029299723902132 0.964227616086639 0.213690959195921 0.790735070893123 mirMAP -0.21730083896034 5.5026733530641e-05 NA NA NA hsa-miR-93-3p SPOCK2 -0.0244435387315667 0.960677870662158 0.213690959195921 0.790735070893123 mirMAP -0.393226290144996 0.00138055150058889 NA NA NA hsa-miR-107 SPRED1 -0.289737369453023 0.769655185893943 0.122957509326979 0.803851034166272 miRanda -0.118093961765081 0.0125580787222769 NA NA NA hsa-miR-15b-5p SPRED1 0.251826642099145 0.790709218602499 0.122957509326979 0.803851034166272 miRNATAP -0.166756378183416 0.000621309059337457 NA NA NA hsa-miR-148a-3p SPRY2 -0.324144803192141 0.746264759480212 -0.152531017422285 0.767354048564953 miRNAWalker2_validate -0.257518358867859 0.00215867572203667 NA NA NA hsa-miR-27a-3p SPRY2 0.309634509674364 0.703724209648479 -0.152531017422285 0.767354048564953 miRNAWalker2_validate;miRTarBase;miRNATAP -0.266966136912299 0.00382810614337747 20638779 By using a reporter-screening assay we discovered that the 3'UTR of Sprouty2 Spry2 carried a putative miR-27a binding site; Furthermore the Spry2 protein which has a low expression level in pancreatic adenocarcinoma was upregulated by transfection with a miR-27a inhibitor; The data reported here are the first to indicate that miR-27a plays an oncogenic role by targeting Spry2 and modulating the malignant biological behavior of pancreatic cancer cells malignant trasformation pancreatic cancer hsa-miR-15b-5p SPRYD3 0.251826642099145 0.790709218602499 0.294858019012453 0.568274429995135 MirTarget;miRNATAP -0.126477617447356 0.00110579165334713 NA NA NA hsa-miR-15b-5p SRC 0.251826642099145 0.790709218602499 -0.194254099489145 0.717069892382555 mirMAP -0.13838291634916 0.00849320285701445 NA NA NA hsa-miR-15b-5p SRCIN1 0.251826642099145 0.790709218602499 -0.545648932282877 0.265036057143992 mirMAP -0.354053412952948 0.0169412638244726 NA NA NA hsa-miR-146a-5p SRD5A2 -0.129284021174742 0.817914855859866 -0.462909313048151 0.445154403704145 MirTarget -0.268804038017892 0.00324383795211424 NA NA NA hsa-miR-326 SRD5A2 0.307641210889423 0.653580115931293 -0.462909313048151 0.445154403704145 miRanda -0.259742070733393 0.0115296373985675 NA NA NA hsa-miR-330-5p SRD5A2 -0.152605584680815 0.787259112745893 -0.462909313048151 0.445154403704145 miRanda -0.339108626529028 0.021548586256592 NA NA NA hsa-miR-132-3p SRGAP3 -0.274411442405805 0.710467071857645 0.188527700782203 0.733084936602565 miRNATAP -0.172652003953814 0.000657472142220342 NA NA NA hsa-miR-212-3p SRGAP3 -0.118513342558296 0.740632149411935 0.188527700782203 0.733084936602565 miRNATAP -0.166815770421336 0.000126628731686676 NA NA NA hsa-miR-382-5p SRGAP3 0.285428145726566 0.561169469243121 0.188527700782203 0.733084936602565 mirMAP -0.116199111466594 0.00103519318848282 NA NA NA hsa-miR-493-5p SRGAP3 0.446650879308971 0.32421223482789 0.188527700782203 0.733084936602565 mirMAP -0.122960958793558 0.000423768170840796 NA NA NA hsa-miR-505-3p SRGAP3 -0.101578624236243 0.868681779756913 0.188527700782203 0.733084936602565 mirMAP -0.133847425354851 0.0329134378717021 NA NA NA hsa-miR-539-5p SRGAP3 0.551428040760553 0.139269787059339 0.188527700782203 0.733084936602565 miRNATAP -0.136433175177079 5.37399156370197e-05 NA NA NA hsa-miR-589-5p SRGAP3 -0.181894068226246 0.778993585147379 0.188527700782203 0.733084936602565 mirMAP;miRNATAP -0.224632030599679 7.56961232428897e-05 NA NA NA hsa-miR-28-5p SRI -0.0511712157419266 0.910958192291954 0.251469160070876 0.663028257688191 miRanda -0.104687145792885 0.0138893280444843 NA NA NA hsa-miR-363-3p SRL -0.186046567396088 0.728622856049059 0.581666925890669 0.105149389394778 mirMAP -0.10945776040442 0.0320469898023863 NA NA NA hsa-miR-107 SRPX -0.289737369453023 0.769655185893943 0.213115937292645 0.585720307202405 miRanda -0.37583278592853 3.93138987266804e-05 NA NA NA hsa-miR-26b-5p SRPX 0.16143906971203 0.790777916193478 0.213115937292645 0.585720307202405 miRNAWalker2_validate -0.44541581982198 7.75743433379249e-06 NA NA NA hsa-miR-320b SRPX 0.298760649675195 0.700446828731538 0.213115937292645 0.585720307202405 miRanda -0.155524079856757 0.0233812169782777 NA NA NA hsa-miR-107 SSTR1 -0.289737369453023 0.769655185893943 -0.362278070346641 0.428090859867161 miRanda -0.384102321807902 0.0016750938600533 NA NA NA hsa-miR-150-5p SSTR3 -0.00683324482969283 0.994067057151257 -0.810089083686777 0.146949257131576 mirMAP -0.217439467574994 0.00234122683092669 NA NA NA hsa-miR-27a-3p SSTR3 0.309634509674364 0.703724209648479 -0.810089083686777 0.146949257131576 mirMAP -0.367054255136499 0.00514701027478781 NA NA NA hsa-miR-214-3p SSX2IP 0.0312810611346688 0.952640488671912 -0.0452206205633239 0.920463392921776 MirTarget -0.106090310997664 3.88587245206739e-06 NA NA NA hsa-miR-107 ST13 -0.289737369453023 0.769655185893943 0.122640774158945 0.846360079181928 miRanda;miRNATAP -0.172302691653736 1.08450814338306e-06 NA NA NA hsa-miR-874-3p ST5 -0.0860497301267076 0.887664028968527 0.180766908837272 0.769756969447184 MirTarget -0.126944015238406 0.00230603332905877 NA NA NA hsa-miR-363-3p ST6GAL2 -0.186046567396088 0.728622856049059 0.978242272056301 0.0688473343748512 MirTarget;miRNATAP -0.191714388472952 0.00739975111686379 NA NA NA hsa-miR-629-3p ST6GALNAC2 -0.455149050361454 0.209212127982437 0.0752423939237392 0.899072169098676 MirTarget -0.160797152313239 0.041415190193428 NA NA NA hsa-miR-107 ST6GALNAC3 -0.289737369453023 0.769655185893943 0.350832269722629 0.245440935757866 miRanda -0.163396524383979 0.0491300046206546 NA NA NA hsa-miR-27a-3p ST6GALNAC3 0.309634509674364 0.703724209648479 0.350832269722629 0.245440935757866 MirTarget -0.261889475435175 0.00026828675930838 NA NA NA hsa-miR-98-5p ST8SIA2 -0.0484028619275874 0.910781316485549 0.492411961105007 0.343994944731912 mirMAP -0.24052535404691 0.0181505994510849 NA NA NA hsa-miR-150-5p ST8SIA3 -0.00683324482969283 0.994067057151257 0.413336662572727 0.597168035578911 mirMAP -0.226081681276839 0.0121203064378479 NA NA NA hsa-miR-107 STAC -0.289737369453023 0.769655185893943 0.842823734321813 0.0936655940970346 miRanda -0.331163182851477 0.0273670982561272 NA NA NA hsa-miR-30e-3p STARD13 0.202355073367528 0.857417040078429 0.222592416189301 0.553796608977684 mirMAP -0.164521228297275 0.00854180311821558 NA NA NA hsa-miR-324-5p STARD13 -0.358991607952497 0.499732551112182 0.222592416189301 0.553796608977684 miRanda -0.301175574326805 1.98374425743438e-09 NA NA NA hsa-miR-331-5p STARD13 -0.158202371972628 0.561893260130397 0.222592416189301 0.553796608977684 PITA -0.150388726479628 0.00683073736284712 NA NA NA hsa-miR-335-3p STARD13 0.0738544228922926 0.89349398283313 0.222592416189301 0.553796608977684 MirTarget;mirMAP -0.124916998351249 0.000663842483580534 NA NA NA hsa-miR-145-5p STAT1 0.274416577727701 0.766365046835301 -0.810301991287307 0.277496782929759 miRNAWalker2_validate;miRTarBase -0.163658990066292 0.000760100107119945 20098684 MicroRNA 145 targets YES and STAT1 in colon cancer cells; Both YES and STAT1 were verified as direct miR-145 targets colon cancer hsa-miR-125b-5p STC1 0.0074438975183444 0.994154663318355 -0.454211733182381 0.323078635350679 miRNATAP -0.203781708959889 0.00788634461663276 NA NA NA hsa-miR-181c-5p STC1 -0.262596734125804 0.645471285705202 -0.454211733182381 0.323078635350679 miRNATAP -0.16969817588767 0.0132010098116972 NA NA NA hsa-miR-30c-5p STC1 -0.183013966936985 0.833177718550926 -0.454211733182381 0.323078635350679 mirMAP;miRNATAP -0.192562646326175 0.0416716340155323 NA NA NA hsa-miR-30e-5p STC1 -0.00273037859886571 0.997115479601006 -0.454211733182381 0.323078635350679 mirMAP -0.310134754576542 0.000662506631934951 NA NA NA hsa-miR-128-3p STK24 -0.0364518492233463 0.95841670253784 0.0425964726801906 0.950992537967364 MirTarget -0.129962718179589 0.00143221353847595 NA NA NA hsa-miR-15b-5p STK25 0.251826642099145 0.790709218602499 -0.0440739317877048 0.94312920220899 mirMAP -0.105720031675153 0.00175029683647674 NA NA NA hsa-miR-221-3p STK38L -0.261179092929062 0.744019631321393 0.22971715029466 0.680502373691106 MirTarget -0.151993863457492 0.000209188649560788 NA NA NA hsa-miR-222-3p STK38L -0.233673471709747 0.726651775432807 0.22971715029466 0.680502373691106 MirTarget -0.144470277488407 0.000387471451425708 NA NA NA hsa-miR-15b-5p STK40 0.251826642099145 0.790709218602499 -0.080139460670563 0.895993838658318 mirMAP -0.112753336573553 0.0285868839560017 NA NA NA hsa-miR-101-3p STMN1 -0.0149915187591869 0.981999725022451 -0.0949988620441671 0.890421111904625 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.31122242737451 7.9803409676095e-09 NA NA NA hsa-miR-132-3p STMN1 -0.274411442405805 0.710467071857645 -0.0949988620441671 0.890421111904625 miRNAWalker2_validate -0.146033768645742 0.0053471646400596 NA NA NA hsa-miR-199a-5p STMN1 0.248253058498817 0.7461266806999 -0.0949988620441671 0.890421111904625 miRanda -0.20661064743449 1.99289028950782e-08 NA NA NA hsa-miR-199b-5p STMN1 0.415198317247236 0.324258779965011 -0.0949988620441671 0.890421111904625 miRanda -0.158722651291077 3.39255662652434e-06 NA NA NA hsa-miR-223-3p STMN1 -0.219863334942404 0.708457258631868 -0.0949988620441671 0.890421111904625 miRNAWalker2_validate;miRTarBase -0.121355096891945 0.000615142843198793 27577078;18555017;22470493 miR 223 increases gallbladder cancer cell sensitivity to docetaxel by downregulating STMN1; We determined that STMN1 was negatively correlated with and regulated by miR-223 in GBC miR-223 increased GBC sensitivity to docetaxel in vitro and in vivo and the induced sensitivity to docetaxel was suppressed by the restoration of STMN1 expression; These findings indicated that miR-223 might serve as an onco-suppressor that enhances susceptibility to docetaxel by downregulating STMN1 in GBC highlighting its promising therapeutic value;A strong inverse relationship between STMN1 mRNA and miR-223 expressions was shown P = .006; A substantial reduction in STMN1 protein was further demonstrated upon restoration of miR-223 expression in HCC cell lines; We further showed that miR-223 readily could suppress the luciferase activity in reporter construct containing the STMN1 3' untranslated region P = .02;We also explored the regulation of STMN1 expression by microRNA-223; We finally confirmed that STMN1 is a putative downstream target of miR-223 in gastric cancer ;; bladder cancer;liver cancer;gastric cancer hsa-miR-26a-5p STMN1 0.0483232931294246 0.955218190818435 -0.0949988620441671 0.890421111904625 miRNATAP -0.367963918732369 8.00535702991417e-08 NA NA NA hsa-miR-26b-5p STMN1 0.16143906971203 0.790777916193478 -0.0949988620441671 0.890421111904625 miRNATAP -0.137316743786403 0.0486214915653056 NA NA NA hsa-miR-30a-5p STMN1 -0.163405499812159 0.87950357765238 -0.0949988620441671 0.890421111904625 miRNAWalker2_validate -0.112726112285029 0.0162583498975138 NA NA NA hsa-miR-107 STMN2 -0.289737369453023 0.769655185893943 -0.249194632358188 0.703333680556331 miRanda -0.757138859802321 1.66517864111734e-06 NA NA NA hsa-miR-27a-3p STMN2 0.309634509674364 0.703724209648479 -0.249194632358188 0.703333680556331 miRNATAP -0.31981934066347 0.0223508300680308 NA NA NA hsa-miR-140-3p STRBP -0.105651799466207 0.9077781740714 0.0756679172913186 0.876796927946258 mirMAP -0.118394534751618 0.000176253917881932 NA NA NA hsa-miR-125a-5p STX18 -0.00666761469427968 0.994891296705929 0.0489999829823979 0.921303325411478 miRanda -0.201864143906396 0.014257542329924 NA NA NA hsa-miR-15b-5p STX1A 0.251826642099145 0.790709218602499 -0.0148647915230389 0.962426160138325 MirTarget -0.130137990374844 0.0107769002422479 NA NA NA hsa-miR-148a-3p STXBP1 -0.324144803192141 0.746264759480212 0.217059467031071 0.684589343227409 MirTarget -0.127748892814266 0.00110266618432247 NA NA NA hsa-miR-107 SUN2 -0.289737369453023 0.769655185893943 -0.0510341489137325 0.928062906786894 miRanda;miRNATAP -0.215448474568583 3.28100607677142e-05 NA NA NA hsa-miR-15b-5p SUPT3H 0.251826642099145 0.790709218602499 0.166889300321837 0.576308644615075 miRNAWalker2_validate -0.23543646112929 3.18032729017695e-05 NA NA NA hsa-miR-221-3p SUSD5 -0.261179092929062 0.744019631321393 -0.0420397937225279 0.891897159288725 miRNATAP -0.146946032336892 0.0206193088010605 NA NA NA hsa-miR-222-3p SUSD5 -0.233673471709747 0.726651775432807 -0.0420397937225279 0.891897159288725 miRNATAP -0.168088132384665 0.0075175140427915 NA NA NA hsa-miR-222-3p SV2A -0.233673471709747 0.726651775432807 0.0240248027077454 0.95210803409728 miRNAWalker2_validate -0.202399889884245 0.00446290134207727 NA NA NA hsa-miR-221-3p SVIP -0.261179092929062 0.744019631321393 -0.067019771442844 0.866183692691572 MirTarget -0.117661846124318 0.00395731188603821 NA NA NA hsa-miR-222-3p SVIP -0.233673471709747 0.726651775432807 -0.067019771442844 0.866183692691572 MirTarget -0.10495945568955 0.00967604982782453 NA NA NA hsa-miR-107 SYN2 -0.289737369453023 0.769655185893943 0.72714266057588 0.138080519498641 PITA;miRanda -0.289275298944318 0.0482511273774399 NA NA NA hsa-miR-15b-5p SYS1 0.251826642099145 0.790709218602499 0.163812412974545 0.753699839382929 MirTarget -0.13693877757074 0.000113075342446493 NA NA NA hsa-let-7a-5p SYT11 0.0514604984725615 0.971564723582327 0.23909467332648 0.650251904007772 TargetScan;miRNATAP -0.161720570485599 0.0253571848694272 NA NA NA hsa-let-7d-5p SYT11 0.0119393569456978 0.988390093874148 0.23909467332648 0.650251904007772 miRNATAP -0.262719504106139 5.59381050299073e-05 NA NA NA hsa-let-7f-5p SYT11 -0.399676495198673 0.695365879077383 0.23909467332648 0.650251904007772 miRNATAP -0.174046990541203 0.000140814486048227 NA NA NA hsa-let-7g-5p SYT11 -0.320647530232065 0.660364346555039 0.23909467332648 0.650251904007772 miRNATAP -0.256943430714006 2.2588572168434e-05 NA NA NA hsa-let-7i-5p SYT11 -0.0940710536612883 0.902310710205355 0.23909467332648 0.650251904007772 miRNATAP -0.177017571283607 0.0052566005708168 NA NA NA hsa-miR-186-5p SYT11 -0.246324984406451 0.701310703524093 0.23909467332648 0.650251904007772 miRNATAP -0.27435388538981 0.000213362344598345 NA NA NA hsa-miR-200b-3p SYT11 -0.532909690027328 0.555970111970307 0.23909467332648 0.650251904007772 mirMAP -0.117113944683437 0.0111488789236083 NA NA NA hsa-miR-429 SYT11 -0.596617415946644 0.128967410286089 0.23909467332648 0.650251904007772 mirMAP;miRNATAP -0.1408719755341 0.00199256470868572 NA NA NA hsa-miR-532-5p SYT11 -0.221248694078637 0.810607004905798 0.23909467332648 0.650251904007772 PITA -0.19505869577924 0.000414544013684501 NA NA NA hsa-miR-939-5p SYT11 -0.00957793796296125 0.973362007496516 0.23909467332648 0.650251904007772 MirTarget -0.192681500788087 0.00443381343220044 NA NA NA hsa-miR-22-3p SYT13 0.0468440219945929 0.967778504781139 -0.997651837798931 0.0654304331964072 MirTarget -0.338638562445918 0.00187793106996169 NA NA NA hsa-miR-106a-5p TACC1 -0.820057689616516 0.0254490146664247 -0.015279710691634 0.978060089793495 MirTarget -0.127636642210958 0.00238648820688451 NA NA NA hsa-miR-17-5p TACC1 -0.643066792834501 0.320674049526638 -0.015279710691634 0.978060089793495 MirTarget;TargetScan -0.191724860527745 0.000234268770972864 NA NA NA hsa-miR-18a-3p TACC1 -0.188202012159778 0.618004963641688 -0.015279710691634 0.978060089793495 MirTarget;miRNATAP -0.27268054814966 1.88925334887871e-06 NA NA NA hsa-miR-93-5p TACC1 -0.375078982324499 0.732311284477601 -0.015279710691634 0.978060089793495 MirTarget -0.140321072176864 0.0238078291561553 NA NA NA hsa-miR-140-3p TADA3 -0.105651799466207 0.9077781740714 0.276416517457551 0.665415332912267 miRNATAP -0.104114633100298 0.00122393246536179 NA NA NA hsa-miR-29a-3p TAF11 0.203872357562561 0.859946061784007 -0.110510658914908 0.807835835031911 MirTarget -0.189004292824991 4.20060836709318e-09 NA NA NA hsa-miR-29b-3p TAF11 -0.249746665931503 0.558208927436524 -0.110510658914908 0.807835835031911 MirTarget -0.115562105636308 4.68025859786605e-07 NA NA NA hsa-miR-29c-3p TAF11 0.042533372292219 0.941334605544826 -0.110510658914908 0.807835835031911 MirTarget -0.112488604849006 2.29931460860152e-05 NA NA NA hsa-miR-140-3p TAF2 -0.105651799466207 0.9077781740714 -0.0856192068455179 0.872814896690292 miRNATAP -0.108912135492718 0.00244961361319608 NA NA NA hsa-miR-181a-5p TAF2 -0.0320774839604816 0.975806098950371 -0.0856192068455179 0.872814896690292 miRNAWalker2_validate -0.140999977457976 5.95251503033432e-05 NA NA NA hsa-miR-139-5p TAF4B -0.0625698939687087 0.914810329989088 0.00389452570436832 0.991726959970854 miRanda -0.11008059518502 0.0309150656223534 NA NA NA hsa-miR-128-3p TAGLN -0.0364518492233463 0.95841670253784 0.997827025417021 0.190207406284929 miRNAWalker2_validate -0.308385458495059 0.00574575236771438 NA NA NA hsa-miR-107 TAL1 -0.289737369453023 0.769655185893943 -0.184039467903688 0.466470270206865 miRanda -0.205689211850199 0.00426938313308384 NA NA NA hsa-miR-15b-5p TAL1 0.251826642099145 0.790709218602499 -0.184039467903688 0.466470270206865 mirMAP -0.222918939712038 0.00274651331021345 NA NA NA hsa-miR-107 TAX1BP3 -0.289737369453023 0.769655185893943 -0.0571247207043006 0.928195926755751 miRanda -0.127963987245438 0.00474482690672056 NA NA NA hsa-miR-107 TBC1D13 -0.289737369453023 0.769655185893943 -0.0974357815321332 0.839851571620022 miRanda -0.108561143141656 0.00583257849669473 NA NA NA hsa-miR-15b-5p TBC1D13 0.251826642099145 0.790709218602499 -0.0974357815321332 0.839851571620022 MirTarget -0.103875367868 0.0108707443834051 NA NA NA hsa-miR-15b-5p TBC1D16 0.251826642099145 0.790709218602499 -0.463553514372146 0.277755749489003 MirTarget -0.178470172483482 0.00139370196460638 NA NA NA hsa-miR-107 TBC1D22A -0.289737369453023 0.769655185893943 0.134802414803678 0.757392133441859 miRanda -0.140433921782806 0.00031711265635646 NA NA NA hsa-miR-221-3p TBC1D24 -0.261179092929062 0.744019631321393 -0.107580416768721 0.788029258398955 mirMAP -0.218379951505083 1.36975797685655e-06 NA NA NA hsa-miR-222-3p TBC1D24 -0.233673471709747 0.726651775432807 -0.107580416768721 0.788029258398955 mirMAP -0.223339889913057 6.2092577074056e-07 NA NA NA hsa-miR-363-3p TBC1D24 -0.186046567396088 0.728622856049059 -0.107580416768721 0.788029258398955 mirMAP -0.104248591360022 0.000182287017308451 NA NA NA hsa-miR-27a-3p TBKBP1 0.309634509674364 0.703724209648479 -0.253779449183232 0.513141488182722 miRNATAP -0.121893757541277 0.0132375103583885 NA NA NA hsa-miR-98-5p TBKBP1 -0.0484028619275874 0.910781316485549 -0.253779449183232 0.513141488182722 MirTarget -0.168278917751602 4.95566707023797e-06 NA NA NA hsa-miR-15b-5p TBP 0.251826642099145 0.790709218602499 0.0240545192161061 0.948626276922458 MirTarget;miRNATAP -0.150084575039038 0.000104620457240841 NA NA NA hsa-miR-140-3p TCEA1 -0.105651799466207 0.9077781740714 -0.0321392826075737 0.9519614659549 MirTarget -0.118383746987478 0.000286577149659912 NA NA NA hsa-miR-106b-5p TCEAL1 -0.3941595235172 0.389635342155994 0.0575213883378725 0.883812788871275 miRNAWalker2_validate;miRTarBase -0.181579048145961 1.28228107584701e-06 NA NA NA hsa-miR-22-3p TCEAL1 0.0468440219945929 0.967778504781139 0.0575213883378725 0.883812788871275 miRNAWalker2_validate;miRTarBase -0.139556325471307 5.46840949616891e-06 NA NA NA hsa-miR-26b-5p TCEAL1 0.16143906971203 0.790777916193478 0.0575213883378725 0.883812788871275 miRNAWalker2_validate -0.113719022193946 0.0101151292312968 NA NA NA hsa-miR-129-5p TCN1 0.417083435812871 0.454236109516901 -0.0802400326691313 0.912816113664995 miRanda -0.312762397104492 0.0013083723645869 NA NA NA hsa-miR-342-3p TCTN1 -0.233020179388453 0.739959578456401 -0.03027344079171 0.947600285767169 miRanda -0.105166738208803 0.0338313397569582 NA NA NA hsa-miR-125a-5p TDG -0.00666761469427968 0.994891296705929 -0.0632929625127723 0.877879427174928 miRNAWalker2_validate;miRanda -0.204307119586493 0.000587620368724825 NA NA NA hsa-miR-186-5p TDG -0.246324984406451 0.701310703524093 -0.0632929625127723 0.877879427174928 mirMAP -0.113220873375417 0.0133847461204425 NA NA NA hsa-miR-28-5p TDG -0.0511712157419266 0.910958192291954 -0.0632929625127723 0.877879427174928 miRanda -0.101419969959131 0.0228910889001358 NA NA NA hsa-miR-29a-3p TDG 0.203872357562561 0.859946061784007 -0.0632929625127723 0.877879427174928 miRNATAP -0.252859395335127 4.51834923039901e-14 NA NA NA hsa-miR-29b-3p TDG -0.249746665931503 0.558208927436524 -0.0632929625127723 0.877879427174928 miRNATAP -0.149772861605219 4.95042104355307e-10 NA NA NA hsa-miR-29c-3p TDG 0.042533372292219 0.941334605544826 -0.0632929625127723 0.877879427174928 miRNAWalker2_validate;miRTarBase;miRNATAP -0.119535757510572 2.26352608130311e-05 NA NA NA hsa-miR-30b-5p TDG -0.298771188216537 0.582864939841563 -0.0632929625127723 0.877879427174928 mirMAP -0.15220356005984 6.84857882494546e-06 NA NA NA hsa-miR-30d-5p TDG -0.127037899273548 0.917197761243139 -0.0632929625127723 0.877879427174928 mirMAP;miRNATAP -0.201816138454968 8.41143816093779e-07 NA NA NA hsa-miR-320c TDG 0.092255964601645 0.785539881268253 -0.0632929625127723 0.877879427174928 PITA;miRanda;miRNATAP -0.117820021152766 0.000318674784661643 NA NA NA hsa-miR-320d TDG 0.353471568894745 0.357430999251147 -0.0632929625127723 0.877879427174928 PITA;miRanda;miRNATAP -0.10780980331884 2.34563095654706e-05 NA NA NA hsa-let-7g-3p TDO2 0.248633620708335 0.513563891445278 0.401323571838499 0.420793902801105 MirTarget;miRNATAP -0.221933554093254 0.0389052293124884 NA NA NA hsa-miR-129-5p TDO2 0.417083435812871 0.454236109516901 0.401323571838499 0.420793902801105 miRanda -0.294035822501735 4.31547922213651e-05 NA NA NA hsa-miR-320c TDO2 0.092255964601645 0.785539881268253 0.401323571838499 0.420793902801105 miRanda -0.220470297071599 0.0395911360762327 NA NA NA hsa-miR-107 TEF -0.289737369453023 0.769655185893943 -0.0675569807781331 0.875863926219485 mirMAP -0.199090940711487 0.000150305254729714 NA NA NA hsa-miR-27a-3p TET1 0.309634509674364 0.703724209648479 -0.0402960153837664 0.899827297880249 MirTarget -0.21865042404919 0.000867213635902811 NA NA NA hsa-miR-320b TFF3 0.298760649675195 0.700446828731538 0.45696481640849 0.534807130189006 miRanda -0.328734294842465 0.0451699355081522 NA NA NA hsa-miR-16-5p TFPI -0.199225750365017 0.742834324195084 -0.148538776747738 0.668037187811931 miRNAWalker2_validate -0.18372897246387 0.00713885905209792 NA NA NA hsa-miR-200b-3p TFPI -0.532909690027328 0.555970111970307 -0.148538776747738 0.668037187811931 MirTarget -0.203030997587467 9.33614560368973e-05 NA NA NA hsa-miR-200c-3p TFPI -0.333638625701646 0.813830738880144 -0.148538776747738 0.668037187811931 MirTarget -0.254191719603323 3.46738540433792e-06 NA NA NA hsa-miR-30e-3p TFPI 0.202355073367528 0.857417040078429 -0.148538776747738 0.668037187811931 mirMAP -0.314253374333803 0.000230530654218974 NA NA NA hsa-miR-320d TFPI 0.353471568894745 0.357430999251147 -0.148538776747738 0.668037187811931 MirTarget;miRanda -0.122311758784645 0.0101637259825812 NA NA NA hsa-miR-335-3p TFPI 0.0738544228922926 0.89349398283313 -0.148538776747738 0.668037187811931 mirMAP -0.11473265801553 0.0234165575162485 NA NA NA hsa-miR-361-5p TFPI -0.278147578656315 0.728553069590798 -0.148538776747738 0.668037187811931 MirTarget;miRanda;miRNATAP -0.222546484370957 0.0327203836248134 NA NA NA hsa-miR-150-5p TGDS -0.00683324482969283 0.994067057151257 0.125100022922929 0.735461548207356 MirTarget -0.10300316688046 6.99412928928952e-07 NA NA NA hsa-miR-17-5p TGFB1I1 -0.643066792834501 0.320674049526638 0.444226427640252 0.384565913245545 TargetScan -0.14060990925311 0.0119523546990946 NA NA NA hsa-miR-125a-3p TGFBR3 0.124026360619668 0.800539414590835 -0.183993339119696 0.717006715769197 miRanda -0.240887317606356 0.00153774864682809 NA NA NA hsa-miR-148a-3p TGIF2 -0.324144803192141 0.746264759480212 0.0237844750121701 0.967098478906165 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.103151833313873 0.00467588439947331 26638007 Down Regulation of miR 148a Promotes Metastasis by DNA Methylation and is Associated with Prognosis of Skin Cancer by Targeting TGIF2; The purpose of this study was to investigate the methylation status of miR-148a and its effects on the metastasis and prognosis of skin cancer as well as the interaction with TGIF2 gene; Luciferase reporter assay found that TGIF2 gene was a target gene and its expression was suppressed by miR-148a in skin cancer; CONCLUSIONS Taken together the expression of miR-148a was regulated by DNA methylation and targeted by TGIF2 metastasis;worse prognosis sarcoma hsa-miR-106b-5p TGM2 -0.3941595235172 0.389635342155994 0.171645787041872 0.81720923556355 MirTarget -0.301199538946998 0.00172484469491402 NA NA NA hsa-miR-129-5p TGM2 0.417083435812871 0.454236109516901 0.171645787041872 0.81720923556355 miRanda;mirMAP -0.235121927623563 6.84947556506326e-06 NA NA NA hsa-miR-17-5p TGM2 -0.643066792834501 0.320674049526638 0.171645787041872 0.81720923556355 MirTarget -0.227967462124644 0.00325794522332314 NA NA NA hsa-miR-93-5p TGM2 -0.375078982324499 0.732311284477601 0.171645787041872 0.81720923556355 MirTarget -0.260397711283994 0.00450614935322244 NA NA NA hsa-miR-15b-5p THRA 0.251826642099145 0.790709218602499 -0.0207553900614785 0.967087576514824 miRNAWalker2_validate -0.137513119226872 0.0106962519521043 NA NA NA hsa-let-7b-5p TIA1 0.396604576702067 0.783406687058469 -0.157008823042438 0.778990769960707 MirTarget;miRNATAP -0.107821855282694 0.000821384739101688 NA NA NA hsa-let-7d-5p TIA1 0.0119393569456978 0.988390093874148 -0.157008823042438 0.778990769960707 MirTarget -0.116640587755354 0.00179505919139374 NA NA NA hsa-miR-27a-3p TIA1 0.309634509674364 0.703724209648479 -0.157008823042438 0.778990769960707 miRNATAP -0.130420448597275 0.000180650929668782 NA NA NA hsa-miR-139-5p TIAM2 -0.0625698939687087 0.914810329989088 -0.0229489514098309 0.942347420290614 miRanda -0.123150987357481 0.043367209740252 NA NA NA hsa-miR-320c TIMELESS 0.092255964601645 0.785539881268253 -0.332968428960332 0.511813981531475 miRanda -0.109051096285613 0.0145637396336096 NA NA NA hsa-miR-106b-5p TIMP2 -0.3941595235172 0.389635342155994 0.160878594170843 0.835179961649693 miRNATAP -0.225086068446412 0.000144696984219656 NA NA NA hsa-miR-17-5p TIMP2 -0.643066792834501 0.320674049526638 0.160878594170843 0.835179961649693 TargetScan;miRNATAP -0.115945827015111 0.015840869104554 NA NA NA hsa-miR-182-5p TIMP2 -0.262297863136789 0.8110070165759 0.160878594170843 0.835179961649693 mirMAP -0.177772042330535 2.26352466035458e-07 NA NA NA hsa-miR-18a-3p TIMP2 -0.188202012159778 0.618004963641688 0.160878594170843 0.835179961649693 MirTarget;miRNATAP -0.123396540004497 0.0203923934810925 NA NA NA hsa-miR-200b-3p TIMP2 -0.532909690027328 0.555970111970307 0.160878594170843 0.835179961649693 TargetScan -0.181620287054961 9.65469941489008e-06 23205572 A novel target of miR-200b tissue inhibitor of metalloproteinase 2 TIMP2 was predicted using a bioinformatics approach and was confirmed in human endometrial cancer cell line HEC-1A cells by luciferase assay quantitative real-time polymerase chain reaction western blotting and enzyme-linked immunosorbent assay; We found that miR-200b repressed TIMP2 expression at both the messenger RNA and protein levels although a family member miR-200a had no such effect; Using reverse gelatin zymography we showed that miR-200b enhances matrix metallopeptidase 2 MMP2 activity by downregulating TIMP2 expression in HEC-1A cells endometrial cancer hsa-miR-200c-3p TIMP2 -0.333638625701646 0.813830738880144 0.160878594170843 0.835179961649693 miRTarBase -0.21746720915401 5.06666582586555e-07 NA NA NA hsa-miR-429 TIMP2 -0.596617415946644 0.128967410286089 0.160878594170843 0.835179961649693 PITA;miRanda;miRNATAP -0.100510513956376 0.014519811331199 NA NA NA hsa-miR-93-5p TIMP2 -0.375078982324499 0.732311284477601 0.160878594170843 0.835179961649693 miRNATAP -0.200218756916777 0.00039530988389672 NA NA NA hsa-miR-660-5p TIMP3 -0.561687438133488 0.138270972367544 1.06975193073475 0.149989388698928 miRNATAP -0.28338523480551 4.33501695274483e-05 NA NA NA hsa-miR-26b-5p TK1 0.16143906971203 0.790777916193478 -0.0279815481425736 0.960587222218451 miRNAWalker2_validate -0.188727657329201 0.017880209085632 NA NA NA hsa-miR-15b-5p TLL1 0.251826642099145 0.790709218602499 0.309018979240895 0.545921599719278 miRNATAP -0.350151699162044 0.025754066118922 NA NA NA hsa-miR-128-3p TM4SF1 -0.0364518492233463 0.95841670253784 -0.0820718634976156 0.916781847907386 miRNAWalker2_validate -0.197203168604647 0.0230167148468009 NA NA NA hsa-miR-129-5p TM4SF1 0.417083435812871 0.454236109516901 -0.0820718634976156 0.916781847907386 mirMAP -0.114196100186317 0.00770884023482934 NA NA NA hsa-miR-338-3p TM4SF1 -0.107178830331044 0.818042702366464 -0.0820718634976156 0.916781847907386 miRanda -0.134445542807133 0.00386102460001486 NA NA NA hsa-miR-150-3p TMEFF1 -0.419098198991827 0.371449470483153 -0.0277264365353167 0.942060102740276 MirTarget -0.112320760907062 0.00506481692741027 NA NA NA hsa-miR-200a-3p TMEFF1 -0.801422367541981 0.147987649395985 -0.0277264365353167 0.942060102740276 MirTarget -0.177407733973544 0.000838012710191805 NA NA NA hsa-miR-21-3p TMEFF1 0.129101420041684 0.877913267462969 -0.0277264365353167 0.942060102740276 MirTarget -0.241451760729105 1.36396684233747e-05 NA NA NA hsa-miR-342-3p TMEFF1 -0.233020179388453 0.739959578456401 -0.0277264365353167 0.942060102740276 PITA;miRanda -0.200651295130489 0.0112410469583762 NA NA NA hsa-miR-107 TMEM100 -0.289737369453023 0.769655185893943 0.495535461682809 0.457476870691068 miRanda -0.432748040002823 0.0256855165357337 NA NA NA hsa-miR-15b-5p TMEM100 0.251826642099145 0.790709218602499 0.495535461682809 0.457476870691068 MirTarget -0.591713366004596 0.00310238220629212 NA NA NA hsa-miR-150-5p TMEM108 -0.00683324482969283 0.994067057151257 0.131469366547538 0.76621738360944 MirTarget -0.123320292267155 0.0299052467952595 NA NA NA hsa-miR-197-3p TMEM120B 0.0240027695773914 0.981971058073739 -0.262167035576774 0.570219584061826 mirMAP -0.125514507103151 0.00684987938109266 NA NA NA hsa-miR-197-3p TMEM129 0.0240027695773914 0.981971058073739 0.069555103885345 0.895145250242225 miRNATAP -0.120309807802225 0.0211493161413807 NA NA NA hsa-miR-15b-5p TMEM130 0.251826642099145 0.790709218602499 0.629647070600561 0.169575109538357 mirMAP -0.460681674447719 0.000274048820878601 NA NA NA hsa-miR-26b-5p TMEM132A 0.16143906971203 0.790777916193478 0.0184873403100649 0.974798468945614 miRNAWalker2_validate -0.274920632276222 0.000130234162246097 NA NA NA hsa-miR-29a-3p TMEM132A 0.203872357562561 0.859946061784007 0.0184873403100649 0.974798468945614 MirTarget -0.274314912258233 1.82203061130809e-07 NA NA NA hsa-miR-29b-3p TMEM132A -0.249746665931503 0.558208927436524 0.0184873403100649 0.974798468945614 MirTarget -0.205187510826115 3.17706557414269e-08 NA NA NA hsa-miR-29c-3p TMEM132A 0.042533372292219 0.941334605544826 0.0184873403100649 0.974798468945614 MirTarget -0.153417863188005 0.000403990037874234 NA NA NA hsa-miR-150-5p TMEM132B -0.00683324482969283 0.994067057151257 -0.109537687118984 0.831840360812673 mirMAP -0.225276345531644 0.00170619550467815 NA NA NA hsa-miR-221-3p TMEM132B -0.261179092929062 0.744019631321393 -0.109537687118984 0.831840360812673 miRNAWalker2_validate -0.371242569854709 0.00175664134268799 NA NA NA hsa-miR-107 TMEM143 -0.289737369453023 0.769655185893943 -0.0760239801811755 0.81088683621981 miRanda -0.111441662196624 0.0148977118625035 NA NA NA hsa-miR-381-3p TMEM14C 0.269633663970002 0.562625029053898 0.133399066454686 0.829924171103182 MirTarget -0.138422345640014 2.46295869871273e-06 NA NA NA hsa-miR-22-3p TMEM155 0.0468440219945929 0.967778504781139 0.119838378084 0.786499074825218 MirTarget -0.279643570185876 0.00214483328258017 NA NA NA hsa-let-7a-2-3p TMEM165 0.411024905124061 0.349899745787071 0.0161004110547767 0.978616688078294 MirTarget -0.132148521120111 8.53363659555936e-07 NA NA NA hsa-miR-181a-5p TMEM165 -0.0320774839604816 0.975806098950371 0.0161004110547767 0.978616688078294 MirTarget -0.13117772295642 0.00396016549295702 NA NA NA hsa-miR-181b-5p TMEM165 -0.0483087651223055 0.952929800264921 0.0161004110547767 0.978616688078294 MirTarget -0.186177503910007 1.91191963503096e-05 NA NA NA hsa-miR-181c-5p TMEM165 -0.262596734125804 0.645471285705202 0.0161004110547767 0.978616688078294 MirTarget -0.169852306136716 2.06984947412392e-06 NA NA NA hsa-miR-181d-5p TMEM165 -0.294264170071504 0.604392929232074 0.0161004110547767 0.978616688078294 MirTarget -0.128475381904513 4.77050096777592e-05 NA NA NA hsa-miR-769-5p TMEM165 -0.13630313069917 0.742095588741811 0.0161004110547767 0.978616688078294 miRNAWalker2_validate -0.119436183826374 0.0256630950022222 NA NA NA hsa-miR-27a-3p TMEM170B 0.309634509674364 0.703724209648479 -0.0100574758794614 0.975416324554827 miRNAWalker2_validate;MirTarget;miRNATAP -0.136226980948027 0.0017560889688463 NA NA NA hsa-miR-221-3p TMEM183A -0.261179092929062 0.744019631321393 0.0804674839053039 0.884013757053671 miRNAWalker2_validate -0.105441587310156 0.000610909942444742 NA NA NA hsa-miR-15b-5p TMEM198 0.251826642099145 0.790709218602499 0.0174318102775228 0.957818422237259 MirTarget -0.32815052011214 0.000163868995269292 NA NA NA hsa-miR-107 TMEM200A -0.289737369453023 0.769655185893943 0.465556179027795 0.212307261822615 miRanda -0.246775336853897 0.00670599977270861 NA NA NA hsa-miR-107 TMEM200B -0.289737369453023 0.769655185893943 -0.19024674498223 0.619531518636094 miRanda -0.331482079654863 0.00190206474238785 NA NA NA hsa-miR-107 TMEM204 -0.289737369453023 0.769655185893943 -0.0662137731686343 0.818757741159862 miRanda -0.244953482964148 2.68578357423308e-06 NA NA NA hsa-miR-127-3p TMEM27 0.231539840651733 0.822108193638849 0.0749896175653263 0.793064099756029 miRanda -0.152351877710525 0.00243585275648542 NA NA NA hsa-miR-320a TMEM45A 0.142884703798297 0.888511174254355 0.161610266940888 0.697903007874834 miRanda -0.196028424434589 0.00891659361169731 NA NA NA hsa-miR-320b TMEM45A 0.298760649675195 0.700446828731538 0.161610266940888 0.697903007874834 miRanda -0.128659087298038 0.033310393693478 NA NA NA hsa-miR-98-5p TMEM45A -0.0484028619275874 0.910781316485549 0.161610266940888 0.697903007874834 miRNAWalker2_validate -0.168472971306859 0.00166934082747917 NA NA NA hsa-miR-146b-5p TMEM47 0.0340352805627226 0.964565988329585 0.612608627078879 0.202603928299125 miRanda -0.220424260146925 0.000311000421688294 NA NA NA hsa-miR-15b-3p TMEM47 0.0805005446828257 0.846317514546419 0.612608627078879 0.202603928299125 MirTarget;miRNATAP -0.178650603148976 0.0203393192873676 NA NA NA hsa-miR-30b-3p TMEM47 -0.231361964211179 0.496038769366155 0.612608627078879 0.202603928299125 MirTarget;miRNATAP -0.18233112008106 0.0172533626365305 NA NA NA hsa-miR-30b-5p TMEM47 -0.298771188216537 0.582864939841563 0.612608627078879 0.202603928299125 MirTarget -0.333145045304531 4.94607756231075e-06 NA NA NA hsa-miR-30d-5p TMEM47 -0.127037899273548 0.917197761243139 0.612608627078879 0.202603928299125 MirTarget;miRNATAP -0.346632694637698 9.96101269567186e-05 NA NA NA hsa-miR-361-3p TMEM47 -0.398826925662302 0.617283381786186 0.612608627078879 0.202603928299125 MirTarget -0.234953475122269 0.0134623245238882 NA NA NA hsa-miR-429 TMEM47 -0.596617415946644 0.128967410286089 0.612608627078879 0.202603928299125 miRanda -0.170733931705791 0.00471060997380913 NA NA NA hsa-miR-616-5p TMEM47 -0.321509218120179 0.271446046739636 0.612608627078879 0.202603928299125 MirTarget -0.130158492787075 0.0438785175943933 NA NA NA hsa-miR-221-3p TMEM56 -0.261179092929062 0.744019631321393 0.0036729800327393 0.992641575791848 mirMAP -0.177672198939652 0.0117695872266808 NA NA NA hsa-miR-139-5p TMEM68 -0.0625698939687087 0.914810329989088 0.0807876813238737 0.855570576202211 miRanda -0.105346864685216 0.00282063764666919 NA NA NA hsa-miR-127-3p TMOD1 0.231539840651733 0.822108193638849 0.381621851956994 0.565752800293319 miRanda -0.232909043708021 9.4709246372581e-05 NA NA NA hsa-miR-125a-5p TMPRSS4 -0.00666761469427968 0.994891296705929 0.359796225580799 0.63305179542184 miRanda -0.678814660739504 0.00291838305063511 NA NA NA hsa-miR-129-5p TMPRSS4 0.417083435812871 0.454236109516901 0.359796225580799 0.63305179542184 mirMAP -0.345726390698278 4.48070398756873e-05 NA NA NA hsa-miR-26b-3p TMPRSS4 0.439281614278881 0.326101870050538 0.359796225580799 0.63305179542184 mirMAP -0.508981970380427 0.00184058776671753 NA NA NA hsa-miR-335-3p TMPRSS4 0.0738544228922926 0.89349398283313 0.359796225580799 0.63305179542184 mirMAP -0.305299329565361 0.00348010778724278 NA NA NA hsa-miR-338-3p TMPRSS4 -0.107178830331044 0.818042702366464 0.359796225580799 0.63305179542184 miRanda -0.208629809703507 0.0248782105981116 NA NA NA hsa-miR-214-3p TMPRSS6 0.0312810611346688 0.952640488671912 -0.743097025413063 0.225222630341586 MirTarget -0.325212121811295 0.00103105030153664 NA NA NA hsa-miR-22-3p TMSB15B 0.0468440219945929 0.967778504781139 -0.56272692642928 0.161491437086946 MirTarget -0.354955263632488 0.000109650093763054 NA NA NA hsa-miR-27a-3p TMTC4 0.309634509674364 0.703724209648479 -0.149033403401955 0.761009839662486 MirTarget -0.118516483962212 0.00608819935940793 NA NA NA hsa-miR-129-5p TNC 0.417083435812871 0.454236109516901 0.024431552330312 0.967302114495993 miRanda -0.254279355639274 2.88456026678165e-05 NA NA NA hsa-miR-425-5p TNC -0.260590453490611 0.72116723892515 0.024431552330312 0.967302114495993 MirTarget -0.221353749873305 0.0287653570115206 NA NA NA hsa-miR-9-5p TNC 0.029299723902132 0.964227616086639 0.024431552330312 0.967302114495993 MirTarget;miRNATAP -0.134348259462923 0.0100841602974547 NA NA NA hsa-miR-125b-5p TNFAIP2 0.0074438975183444 0.994154663318355 0.0132828937581646 0.986774484615124 mirMAP -0.202109334209873 0.00631938062531027 NA NA NA hsa-miR-760 TNFAIP2 -0.149600635966191 0.803293629709251 0.0132828937581646 0.986774484615124 MirTarget -0.185283909727103 0.000512520532701375 NA NA NA hsa-miR-940 TNFAIP2 0.19340062942074 0.679749292292113 0.0132828937581646 0.986774484615124 MirTarget -0.121078107111278 0.0410594088477124 NA NA NA hsa-miR-129-5p TNFAIP6 0.417083435812871 0.454236109516901 0.395152985719554 0.358884259851706 miRanda -0.31893290046788 3.58805942065527e-07 NA NA NA hsa-miR-194-3p TNFAIP6 0.012041841961977 0.978632170113365 0.395152985719554 0.358884259851706 MirTarget -0.193810655725028 0.0296651095920008 NA NA NA hsa-miR-16-5p TNFRSF12A -0.199225750365017 0.742834324195084 0.163687289098192 0.776908644380439 miRNAWalker2_validate -0.204160559709641 0.000202239457859202 NA NA NA hsa-miR-139-5p TNFSF10 -0.0625698939687087 0.914810329989088 -0.199509460716673 0.77958190246055 miRanda -0.209661974968205 0.0159374737274873 NA NA NA hsa-miR-150-5p TNNI1 -0.00683324482969283 0.994067057151257 -0.212983430781827 0.566415468673695 mirMAP -0.218154905156732 5.82392293652961e-06 NA NA NA hsa-miR-214-3p TNNI1 0.0312810611346688 0.952640488671912 -0.212983430781827 0.566415468673695 mirMAP -0.109992781486758 0.0466883584147196 NA NA NA hsa-miR-148a-3p TNRC6C -0.324144803192141 0.746264759480212 -0.134000207956508 0.780052304855693 MirTarget;miRNATAP -0.113441214182673 0.0498542446416197 NA NA NA hsa-miR-15b-5p TOM1L2 0.251826642099145 0.790709218602499 -0.0981479526981506 0.842393354245454 mirMAP -0.106716698993049 0.0220311626661852 NA NA NA hsa-miR-221-3p TOX -0.261179092929062 0.744019631321393 0.137205334580283 0.765617454626825 MirTarget;miRNATAP -0.200080441653313 0.0360254014278339 NA NA NA hsa-miR-222-3p TOX -0.233673471709747 0.726651775432807 0.137205334580283 0.765617454626825 MirTarget;miRNATAP -0.194169536682037 0.0403201812130837 NA NA NA hsa-miR-107 TOX3 -0.289737369453023 0.769655185893943 -0.452475137758743 0.566719290713149 miRanda -0.841252159522854 0.000275670761381235 NA NA NA hsa-miR-22-3p TP73 0.0468440219945929 0.967778504781139 -0.344008159401897 0.412099831484199 mirMAP -0.312057040050556 0.0007192821797829 NA NA NA hsa-miR-107 TPM1 -0.289737369453023 0.769655185893943 0.360725453308555 0.566732511981325 PITA;miRanda -0.171794605278954 0.000702170009887133 NA NA NA hsa-miR-150-5p TPPP -0.00683324482969283 0.994067057151257 -0.427319842741888 0.328546375694931 mirMAP -0.192985890456036 0.000110469357511995 NA NA NA hsa-miR-214-3p TPPP 0.0312810611346688 0.952640488671912 -0.427319842741888 0.328546375694931 MirTarget -0.143355115281518 0.011837673724967 NA NA NA hsa-miR-150-3p TPPP3 -0.419098198991827 0.371449470483153 0.554995852636311 0.281321606493371 MirTarget -0.16634010171269 0.00232859132931557 NA NA NA hsa-miR-15a-5p TPPP3 -0.288312177100971 0.506274963146038 0.554995852636311 0.281321606493371 MirTarget;miRNATAP -0.203711009905477 0.0100530377609165 NA NA NA hsa-miR-15b-5p TPPP3 0.251826642099145 0.790709218602499 0.554995852636311 0.281321606493371 MirTarget;miRNATAP -0.464226846574161 8.27241606780802e-05 NA NA NA hsa-miR-16-5p TPPP3 -0.199225750365017 0.742834324195084 0.554995852636311 0.281321606493371 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.20297213648977 0.0388771389221818 NA NA NA hsa-miR-214-3p TPPP3 0.0312810611346688 0.952640488671912 0.554995852636311 0.281321606493371 mirMAP -0.165237406915171 0.00754692961963128 NA NA NA hsa-miR-330-5p TPPP3 -0.152605584680815 0.787259112745893 0.554995852636311 0.281321606493371 miRanda -0.346935360226518 0.000530733172139666 NA NA NA hsa-miR-511-5p TPPP3 0.0769767272646993 0.826812071949886 0.554995852636311 0.281321606493371 MirTarget -0.156017927664172 0.0295944652365489 NA NA NA hsa-miR-106b-5p TRAF3IP2 -0.3941595235172 0.389635342155994 0.320216554313162 0.481918849862603 mirMAP -0.10631313685273 0.0354955358297958 NA NA NA hsa-miR-660-5p TRAM1L1 -0.561687438133488 0.138270972367544 -0.0279947673698322 0.938467850530622 MirTarget -0.140181960781931 0.0054458544678906 NA NA NA hsa-miR-197-3p TRAP1 0.0240027695773914 0.981971058073739 -0.0638748503438986 0.9196438159383 miRNAWalker2_validate -0.107007447737117 0.0218163878936225 NA NA NA hsa-miR-363-3p TRHDE -0.186046567396088 0.728622856049059 -0.503591479868391 0.503735138690962 MirTarget -0.462344149906924 1.41737242323792e-05 NA NA NA hsa-miR-106b-5p TRIB2 -0.3941595235172 0.389635342155994 -0.102338105476567 0.854624378266175 miRNAWalker2_validate -0.205451773501993 0.0034793566794403 NA NA NA hsa-miR-129-5p TRIB2 0.417083435812871 0.454236109516901 -0.102338105476567 0.854624378266175 miRanda;mirMAP -0.11014756734961 0.00432075220343263 NA NA NA hsa-miR-139-5p TRIB2 -0.0625698939687087 0.914810329989088 -0.102338105476567 0.854624378266175 miRanda -0.132920149670936 0.0300890686439299 NA NA NA hsa-miR-141-5p TRIB2 -0.41673325588269 0.491200782452983 -0.102338105476567 0.854624378266175 MirTarget;miRNATAP -0.109057525134115 0.0154368464864817 NA NA NA hsa-miR-18a-3p TRIB2 -0.188202012159778 0.618004963641688 -0.102338105476567 0.854624378266175 miRNATAP -0.139617073508898 0.0263672481831097 NA NA NA hsa-miR-378a-5p TRIB2 -0.031968081769751 0.969717820343558 -0.102338105476567 0.854624378266175 MirTarget -0.105426788679098 0.0413576471240995 NA NA NA hsa-miR-576-5p TRIB2 -0.521065838204864 0.11793493718786 -0.102338105476567 0.854624378266175 PITA -0.155381138623027 0.00400956414451905 NA NA NA hsa-miR-99a-5p TRIB2 -0.3629378786679 0.683949996110801 -0.102338105476567 0.854624378266175 MirTarget;miRNATAP -0.158349336554845 0.00248197316852065 24137458 miR 99 inhibits cervical carcinoma cell proliferation by targeting TRIB2 cervical and endocervical cancer hsa-miR-128-3p TRIL -0.0364518492233463 0.95841670253784 0.0497405381840634 0.911129653245057 MirTarget -0.198386382366554 0.0290084447819276 NA NA NA hsa-miR-27a-3p TRIL 0.309634509674364 0.703724209648479 0.0497405381840634 0.911129653245057 MirTarget -0.24239324698574 0.00136139144828037 NA NA NA hsa-miR-22-3p TRIM13 0.0468440219945929 0.967778504781139 0.262542294186431 0.543661979211902 MirTarget -0.112757313383984 2.89174152457273e-05 NA NA NA hsa-miR-221-3p TRIM28 -0.261179092929062 0.744019631321393 -0.215733702038978 0.782259764856798 miRNAWalker2_validate -0.161138368105934 1.17773441923775e-05 NA NA NA hsa-miR-22-3p TRIM46 0.0468440219945929 0.967778504781139 -0.190343616955162 0.567899456007158 MirTarget -0.115349673456273 0.0482677342328698 NA NA NA hsa-miR-150-5p TRIM9 -0.00683324482969283 0.994067057151257 0.346366420432361 0.326595697296757 MirTarget -0.118078814506791 0.0162493371067559 NA NA NA hsa-miR-128-3p TRMT112 -0.0364518492233463 0.95841670253784 0.355893859634828 0.554020429315035 miRNAWalker2_validate -0.103542139281542 0.0395692790531055 NA NA NA hsa-miR-140-3p TRMT12 -0.105651799466207 0.9077781740714 0.0170292766100317 0.969459251263261 miRNATAP -0.237881014518689 3.75796188801902e-07 NA NA NA hsa-miR-107 TRPC1 -0.289737369453023 0.769655185893943 0.37368275609971 0.236767305992153 PITA;miRanda -0.263875846378283 0.000397705959589721 NA NA NA hsa-miR-22-3p TRUB1 0.0468440219945929 0.967778504781139 0.37968833000394 0.425876794753803 MirTarget;miRNATAP -0.110109165329879 0.000138639232247675 NA NA NA hsa-miR-150-3p TSGA10 -0.419098198991827 0.371449470483153 -0.0293819901612351 0.922698750722175 MirTarget -0.112893541508848 3.27168516941479e-05 NA NA NA hsa-miR-221-3p TSN -0.261179092929062 0.744019631321393 0.0311637975762986 0.957135222937734 miRNAWalker2_validate -0.123526330743134 1.05323897555343e-06 NA NA NA hsa-miR-629-5p TSPAN1 -0.466366787435144 0.39007918961798 0.647600701846742 0.329420944274403 MirTarget -0.259550292814244 0.0319031876088568 NA NA NA hsa-miR-221-3p TSPAN13 -0.261179092929062 0.744019631321393 -0.300868373622002 0.54960062245422 MirTarget -0.215259674728405 0.000364620152444175 NA NA NA hsa-miR-222-3p TSPAN13 -0.233673471709747 0.726651775432807 -0.300868373622002 0.54960062245422 MirTarget -0.227998883599021 0.000138283952721022 NA NA NA hsa-miR-107 TSPAN18 -0.289737369453023 0.769655185893943 0.0471456072412799 0.917502737437692 miRanda -0.266739922421182 0.00325078381030981 NA NA NA hsa-miR-98-5p TSPAN18 -0.0484028619275874 0.910781316485549 0.0471456072412799 0.917502737437692 MirTarget -0.211852473083533 0.000393387228838743 NA NA NA hsa-miR-139-5p TSPAN3 -0.0625698939687087 0.914810329989088 0.245791583858663 0.74071464026602 MirTarget;PITA;miRanda;miRNATAP -0.116119508933106 0.00213750417821882 NA NA NA hsa-miR-15b-5p TSPAN3 0.251826642099145 0.790709218602499 0.245791583858663 0.74071464026602 miRNAWalker2_validate -0.100338857029098 0.0371194987960509 NA NA NA hsa-miR-16-5p TSPAN3 -0.199225750365017 0.742834324195084 0.245791583858663 0.74071464026602 miRNAWalker2_validate -0.132343528240516 0.00080399125329679 NA NA NA hsa-miR-23a-3p TSPAN3 0.174045248211037 0.865717934161724 0.245791583858663 0.74071464026602 mirMAP -0.186624651519941 5.35523467677224e-05 NA NA NA hsa-miR-423-5p TSPAN3 -0.314923545892784 0.658894400879422 0.245791583858663 0.74071464026602 PITA -0.143651174233354 0.0055691924526164 NA NA NA hsa-miR-107 TSPAN5 -0.289737369453023 0.769655185893943 -0.125280682002613 0.668611877673025 MirTarget;PITA;miRanda;miRNATAP -0.209178739247765 0.00847231943636534 NA NA NA hsa-let-7a-5p TTC26 0.0514604984725615 0.971564723582327 0.0121324998619419 0.968207511370373 miRNAWalker2_validate -0.158550353654728 0.000831148016814182 NA NA NA hsa-let-7b-3p TTC26 0.314328399485033 0.684245834514538 0.0121324998619419 0.968207511370373 mirMAP -0.19067396697062 2.06797591238935e-06 NA NA NA hsa-miR-214-3p TTC39A 0.0312810611346688 0.952640488671912 -0.405615189375337 0.42122438442925 mirMAP -0.243581779011175 1.63799830972633e-05 NA NA NA hsa-miR-221-3p TUB -0.261179092929062 0.744019631321393 -0.374471694175891 0.361995538581085 miRNAWalker2_validate;MirTarget -0.174152807297352 0.00770504894655142 NA NA NA hsa-miR-222-3p TUB -0.233673471709747 0.726651775432807 -0.374471694175891 0.361995538581085 MirTarget -0.169565208360436 0.00893699335780295 NA NA NA hsa-miR-15b-5p TUBA1A 0.251826642099145 0.790709218602499 0.497451462097652 0.480638470292826 MirTarget;miRNATAP -0.284890970983786 0.000271829602292997 NA NA NA hsa-miR-221-3p TUBA1A -0.261179092929062 0.744019631321393 0.497451462097652 0.480638470292826 MirTarget -0.293451194373911 6.14796478982693e-07 NA NA NA hsa-miR-222-3p TUBA1A -0.233673471709747 0.726651775432807 0.497451462097652 0.480638470292826 MirTarget -0.264668069579491 6.31186788260664e-06 NA NA NA hsa-miR-107 TUBG2 -0.289737369453023 0.769655185893943 -0.0903098342594602 0.791396554219377 miRanda -0.104296496427315 0.0153367098797146 NA NA NA hsa-miR-130b-5p TUFT1 -0.318833907124358 0.508178803208229 0.279966862377948 0.534157402496729 mirMAP -0.131397553541018 0.00199967043164147 NA NA NA hsa-miR-194-5p TUSC3 -0.141051051043955 0.809072276924359 0.20981601072723 0.693283838979251 MirTarget -0.114800013132973 0.0284552804418877 NA NA NA hsa-miR-28-5p TUSC3 -0.0511712157419266 0.910958192291954 0.20981601072723 0.693283838979251 miRanda -0.208197156527928 0.0117972562188845 NA NA NA hsa-miR-339-5p TUSC3 -0.121565674268033 0.81427862647099 0.20981601072723 0.693283838979251 miRanda -0.217677276805222 0.00177376831491735 NA NA NA hsa-miR-342-3p TUSC3 -0.233020179388453 0.739959578456401 0.20981601072723 0.693283838979251 miRanda -0.179660021655823 0.0175494478923785 NA NA NA hsa-miR-128-3p TUSC5 -0.0364518492233463 0.95841670253784 1.3864873430346 0.0826715646957805 miRNAWalker2_validate -0.633690876833813 0.00574894075473634 NA NA NA hsa-miR-107 TWIST2 -0.289737369453023 0.769655185893943 0.231822075281934 0.601634751285074 miRanda -0.278512529063725 0.0334304353293569 NA NA NA hsa-miR-139-5p TXNL4B -0.0625698939687087 0.914810329989088 0.0158200231221626 0.968882682385132 miRanda -0.100302218979118 0.0146874648960887 NA NA NA hsa-let-7b-5p TYMS 0.396604576702067 0.783406687058469 -0.123094469211223 0.80169198537477 miRNAWalker2_validate -0.177402877163728 0.000608648590939973 NA NA NA hsa-miR-140-3p UBE2C -0.105651799466207 0.9077781740714 0.0935647546287539 0.871721449106861 miRNAWalker2_validate;miRNATAP -0.141043826755482 0.0369508058535519 NA NA NA hsa-miR-320c UBE2C 0.092255964601645 0.785539881268253 0.0935647546287539 0.871721449106861 miRanda -0.206455981977672 0.000198430220413257 NA NA NA hsa-miR-320d UBE2C 0.353471568894745 0.357430999251147 0.0935647546287539 0.871721449106861 miRanda -0.103307865221451 0.0180930580986924 NA NA NA hsa-miR-222-3p UBE2E3 -0.233673471709747 0.726651775432807 0.0526652875719975 0.923671851549949 miRNATAP -0.158277338908139 1.5176309130381e-07 NA NA NA hsa-miR-221-3p UBE2N -0.261179092929062 0.744019631321393 0.233034483101478 0.691060996748918 miRNAWalker2_validate -0.129364172091801 2.7414293653764e-05 NA NA NA hsa-miR-26a-5p UBE2V2 0.0483232931294246 0.955218190818435 0.0696851552879743 0.88219881265138 mirMAP -0.171206526570343 3.60218732475135e-06 NA NA NA hsa-miR-30c-5p UBE2V2 -0.183013966936985 0.833177718550926 0.0696851552879743 0.88219881265138 MirTarget;mirMAP -0.114118416434555 0.000680755264076437 NA NA NA hsa-miR-30e-5p UBE2V2 -0.00273037859886571 0.997115479601006 0.0696851552879743 0.88219881265138 MirTarget -0.126474169021528 9.82866370349294e-05 NA NA NA hsa-miR-361-5p UBE2V2 -0.278147578656315 0.728553069590798 0.0696851552879743 0.88219881265138 mirMAP -0.120085138753018 0.00665379327109713 NA NA NA hsa-miR-664a-3p UBE2V2 -0.139841943049965 0.800834383581795 0.0696851552879743 0.88219881265138 mirMAP -0.141965529892386 3.88281645997408e-06 NA NA NA hsa-miR-15b-5p UBFD1 0.251826642099145 0.790709218602499 -0.193230914246274 0.735114148719963 MirTarget;miRNATAP -0.137086419176319 0.000110538785224281 NA NA NA hsa-miR-107 UBL3 -0.289737369453023 0.769655185893943 0.248606683593827 0.618581932161698 PITA;miRanda;miRNATAP -0.145414936903315 0.00125608604602751 NA NA NA hsa-miR-16-5p UBL3 -0.199225750365017 0.742834324195084 0.248606683593827 0.618581932161698 MirTarget -0.165656345103081 1.46174133217679e-05 NA NA NA hsa-miR-186-5p UBL3 -0.246324984406451 0.701310703524093 0.248606683593827 0.618581932161698 miRNAWalker2_validate -0.179590269638266 0.000156201113515744 NA NA NA hsa-miR-192-5p UBL3 -0.00281508349767456 0.99638352116085 0.248606683593827 0.618581932161698 miRNAWalker2_validate -0.116128586375598 3.87818549281494e-05 NA NA NA hsa-miR-26b-5p UBL3 0.16143906971203 0.790777916193478 0.248606683593827 0.618581932161698 miRNAWalker2_validate -0.110495991587072 0.0255427504367249 NA NA NA hsa-miR-30e-3p UBL3 0.202355073367528 0.857417040078429 0.248606683593827 0.618581932161698 MirTarget -0.183869827550175 0.000135760489642019 NA NA NA hsa-miR-331-5p UBL3 -0.158202371972628 0.561893260130397 0.248606683593827 0.618581932161698 MirTarget;PITA;miRNATAP -0.160605869494228 0.000178695091147188 NA NA NA hsa-miR-576-5p UBL3 -0.521065838204864 0.11793493718786 0.248606683593827 0.618581932161698 PITA;mirMAP -0.110975283821109 0.00063876674316003 NA NA NA hsa-miR-9-5p UBL3 0.029299723902132 0.964227616086639 0.248606683593827 0.618581932161698 MirTarget -0.105340071183861 6.25940773952236e-08 NA NA NA hsa-miR-107 UBL4A -0.289737369453023 0.769655185893943 -0.115764653952366 0.83373149002251 mirMAP -0.115368513854079 0.00920082852344027 NA NA NA hsa-miR-150-5p UBXN10 -0.00683324482969283 0.994067057151257 -0.0880880090323011 0.843058789010251 mirMAP -0.186467330328161 3.24238661254975e-06 NA NA NA hsa-miR-125a-5p UCHL5 -0.00666761469427968 0.994891296705929 -0.0123958909779542 0.975487978558056 miRanda -0.143197912593223 0.00157027727696751 NA NA NA hsa-miR-34a-5p UCK2 -0.689845719362998 0.195745632660671 0.113471706838113 0.796315237796508 miRNAWalker2_validate -0.103433653741739 0.000465563772504159 NA NA NA hsa-miR-107 UNC119B -0.289737369453023 0.769655185893943 -0.255073342962268 0.619309549823191 MirTarget -0.179898098243373 0.000519073433001128 NA NA NA hsa-miR-15b-5p UNC119B 0.251826642099145 0.790709218602499 -0.255073342962268 0.619309549823191 MirTarget -0.229499282670735 1.68879627754677e-05 NA NA NA hsa-miR-22-3p UNC119B 0.0468440219945929 0.967778504781139 -0.255073342962268 0.619309549823191 MirTarget -0.231976303547296 2.73852140812855e-09 NA NA NA hsa-miR-27a-3p UNC119B 0.309634509674364 0.703724209648479 -0.255073342962268 0.619309549823191 mirMAP -0.251472669058326 1.54006047862445e-08 NA NA NA hsa-miR-15b-5p UNC80 0.251826642099145 0.790709218602499 -0.197447802223713 0.716260322984288 MirTarget;miRNATAP -0.700396429297842 4.05864214268584e-06 NA NA NA hsa-miR-27a-3p UNC80 0.309634509674364 0.703724209648479 -0.197447802223713 0.716260322984288 miRNATAP -0.512020390966268 6.95983858627218e-05 NA NA NA hsa-miR-199a-5p UNG 0.248253058498817 0.7461266806999 -0.19611339207659 0.725230558942511 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.127646423239089 5.91622065543835e-07 NA NA NA hsa-miR-15b-5p USP22 0.251826642099145 0.790709218602499 -0.184221328428914 0.785360558533857 mirMAP -0.11516856536231 0.00263017065672209 NA NA NA hsa-miR-15b-5p USP44 0.251826642099145 0.790709218602499 -0.00667178228043741 0.988552251377592 MirTarget -0.381987457276847 0.00774539705685155 NA NA NA hsa-miR-27a-3p USP51 0.309634509674364 0.703724209648479 -0.434533643728697 0.12323735758093 MirTarget;miRNATAP -0.283603604121282 4.72144671834067e-06 NA NA NA hsa-miR-107 USPL1 -0.289737369453023 0.769655185893943 -0.145684767595889 0.710110110206096 miRanda -0.111029209374844 0.00336512357620763 NA NA NA hsa-miR-140-3p UTP23 -0.105651799466207 0.9077781740714 0.0533937901912331 0.911359493356977 MirTarget -0.118097065273538 0.00514083024028675 NA NA NA hsa-miR-27a-3p VANGL2 0.309634509674364 0.703724209648479 -0.335803172975088 0.550688388728332 miRNATAP -0.128021232736324 0.0337939830851207 NA NA NA hsa-miR-107 VASP -0.289737369453023 0.769655185893943 0.119281349415242 0.840680336891893 miRanda -0.134166180505699 0.00175725367874436 NA NA NA hsa-miR-15b-5p VAT1 0.251826642099145 0.790709218602499 -0.0423137398494644 0.947381666005078 MirTarget;miRNATAP -0.162327415046613 0.000312967334504966 NA NA NA hsa-miR-107 VCAN -0.289737369453023 0.769655185893943 0.628346657399598 0.372826465442762 MirTarget;miRanda;miRNATAP -0.273647950880302 0.0424215723899891 NA NA NA hsa-miR-129-5p VEGFA 0.417083435812871 0.454236109516901 -0.633589138053811 0.349418059337769 miRanda -0.114985263338119 0.000293925025658419 NA NA NA hsa-miR-27a-3p VGF 0.309634509674364 0.703724209648479 -0.521834221163829 0.236881269265871 miRNATAP -0.317795587606075 0.00337904810822699 NA NA NA hsa-miR-1301-3p VIM -0.108695123599309 0.851745507068853 0.20234373870383 0.822140870507452 miRNAWalker2_validate -0.1270554557716 0.0315710519617313 NA NA NA hsa-miR-16-5p VIM -0.199225750365017 0.742834324195084 0.20234373870383 0.822140870507452 miRNAWalker2_validate -0.12308290261942 0.0295088602375066 NA NA NA hsa-miR-17-3p VIM -0.13137566263129 0.849946548607015 0.20234373870383 0.822140870507452 miRNAWalker2_validate;miRNATAP -0.193352142771867 0.000987450656786642 19771525;23418359 The lack of miR-17-3p expression correlated with an increase in vimentin synthesis and tumorigenicity; Stable expression of miR-17-3p in the M12 subline reduced vimentin levels 85% and reverted growth to organized polarized acini in lrECM gels;In contrast the passenger strand miR-17-3p repressed expression of vimentin an intermediate filament with the ability to modulate metabolism and GalNT7 an enzyme that regulates metabolism of liver toxin galactosamine ; prostate cancer;liver cancer hsa-miR-30d-5p VIM -0.127037899273548 0.917197761243139 0.20234373870383 0.822140870507452 miRNATAP -0.220379247632776 0.000492494199964298 NA NA NA hsa-miR-296-3p VNN1 0.305371903227786 0.470342914513253 0.472842722373263 0.311243586957001 miRanda -0.253222213710847 0.00174236612627807 NA NA NA hsa-miR-15b-5p VPS33B 0.251826642099145 0.790709218602499 -0.145533794914663 0.676700992773092 MirTarget -0.126594309180328 0.000763833511871515 NA NA NA hsa-miR-98-5p VPS37B -0.0484028619275874 0.910781316485549 -0.25261967300478 0.631433703344324 mirMAP -0.129147454963126 3.76925740423484e-06 NA NA NA hsa-miR-15b-5p VPS4A 0.251826642099145 0.790709218602499 0.0536316931584118 0.921534502663911 MirTarget -0.111326605943189 0.000432651087804664 NA NA NA hsa-miR-15b-5p VWF 0.251826642099145 0.790709218602499 -0.420988262310166 0.480925419163038 mirMAP -0.223891329720188 0.00013408111214836 NA NA NA hsa-miR-22-3p WARS2 0.0468440219945929 0.967778504781139 -0.00471030719604126 0.991039475433535 MirTarget -0.138942763905713 1.80059737338802e-05 NA NA NA hsa-miR-22-3p WASF1 0.0468440219945929 0.967778504781139 0.321904576132275 0.468217747135163 MirTarget;miRNATAP -0.222873973715986 0.000105546604315301 NA NA NA hsa-miR-107 WASF3 -0.289737369453023 0.769655185893943 0.479341584458325 0.28478842084453 miRNATAP -0.287368061388297 0.000855438068879795 NA NA NA hsa-miR-125a-3p WDR12 0.124026360619668 0.800539414590835 -0.136718804008717 0.744920915442261 miRanda -0.110650831703219 0.00709453602034644 NA NA NA hsa-miR-342-3p WDR19 -0.233020179388453 0.739959578456401 -0.156840474919846 0.69974385134876 miRanda -0.213852011061406 5.158948070841e-06 NA NA NA hsa-miR-221-3p WDR35 -0.261179092929062 0.744019631321393 0.147928942031917 0.722018779863624 MirTarget -0.22098143340468 1.82406739095417e-07 NA NA NA hsa-miR-222-3p WDR35 -0.233673471709747 0.726651775432807 0.147928942031917 0.722018779863624 MirTarget -0.232120913744504 3.04065222200144e-08 NA NA NA hsa-miR-27a-3p WDR35 0.309634509674364 0.703724209648479 0.147928942031917 0.722018779863624 MirTarget -0.131763019564288 0.00585686092103287 NA NA NA hsa-miR-140-3p WDR54 -0.105651799466207 0.9077781740714 0.50409357404074 0.245677056498739 miRNATAP -0.164650998815195 0.00662512843982551 NA NA NA hsa-miR-197-3p WDR6 0.0240027695773914 0.981971058073739 -0.27064989409961 0.6767963113116 miRNAWalker2_validate -0.120232177532212 0.0129023829722883 NA NA NA hsa-miR-221-3p WDR61 -0.261179092929062 0.744019631321393 0.102074286583017 0.827411439218937 miRNAWalker2_validate -0.107147647575167 0.00120246170154264 NA NA NA hsa-miR-320a WDR77 0.142884703798297 0.888511174254355 -0.0369305660491799 0.945940662103407 miRNAWalker2_validate -0.111172035921357 0.0242340625194549 NA NA NA hsa-miR-342-3p WDR77 -0.233020179388453 0.739959578456401 -0.0369305660491799 0.945940662103407 miRanda -0.111921436862373 0.0260222968722794 NA NA NA hsa-miR-214-3p WNK2 0.0312810611346688 0.952640488671912 -0.518842596009533 0.362307003157139 mirMAP -0.136581401016069 0.0244890431862789 NA NA NA hsa-miR-22-3p WNK2 0.0468440219945929 0.967778504781139 -0.518842596009533 0.362307003157139 mirMAP -0.230174916203687 0.00769953195455595 NA NA NA hsa-miR-222-3p WNK3 -0.233673471709747 0.726651775432807 -0.342494588983999 0.23478062644346 miRNATAP -0.142892191763526 0.0117311661396608 NA NA NA hsa-miR-107 WNT4 -0.289737369453023 0.769655185893943 0.177880468975003 0.686335530053085 PITA;miRNATAP -0.335860649413767 0.00436947352247334 NA NA NA hsa-miR-363-3p WNT9A -0.186046567396088 0.728622856049059 0.300264508185338 0.380417543798879 mirMAP -0.153783793288231 0.000947246444880775 NA NA NA hsa-miR-24-3p WRB 0.0408517902063537 0.966828370841971 0.304288830576182 0.491632017262251 miRNAWalker2_validate -0.115041940934891 0.00503572637475121 NA NA NA hsa-miR-330-5p WRB -0.152605584680815 0.787259112745893 0.304288830576182 0.491632017262251 miRanda -0.104842687185942 0.00349444981543815 NA NA NA hsa-miR-107 WTIP -0.289737369453023 0.769655185893943 -0.363367872238865 0.402870698746614 mirMAP -0.191736648051446 0.00289714109685374 NA NA NA hsa-miR-15b-5p WTIP 0.251826642099145 0.790709218602499 -0.363367872238865 0.402870698746614 mirMAP -0.194409320824277 0.00352918151377694 NA NA NA hsa-let-7a-5p XK 0.0514604984725615 0.971564723582327 -0.127181509377647 0.763512785035363 TargetScan;miRNATAP -0.205198644696632 0.0494009879945077 NA NA NA hsa-let-7b-5p XK 0.396604576702067 0.783406687058469 -0.127181509377647 0.763512785035363 miRNATAP -0.18852040085488 0.0215007334126007 NA NA NA hsa-miR-193a-5p XK 0.237612077466578 0.806674211675518 -0.127181509377647 0.763512785035363 TargetScan;miRNATAP -0.369768528941473 0.000146764697677057 NA NA NA hsa-miR-92a-3p XPOT 0.0155161307487504 0.991444817308063 0.172965843330249 0.767359100976734 miRNAWalker2_validate -0.102914810628244 0.015157061503204 NA NA NA hsa-miR-140-3p XRCC5 -0.105651799466207 0.9077781740714 0.0882152000995138 0.905643165814152 MirTarget -0.114958160333596 7.25214211886595e-05 NA NA NA hsa-miR-148a-3p XYLT1 -0.324144803192141 0.746264759480212 0.227300345041255 0.584747858021969 mirMAP -0.206091566194021 0.0163916903959697 NA NA NA hsa-miR-21-5p YAP1 -0.515762857245393 0.64198914412298 0.267969938902053 0.707749488187932 MirTarget;miRNATAP -0.119378373432387 1.14143086606227e-05 NA NA NA hsa-miR-361-3p YAP1 -0.398826925662302 0.617283381786186 0.267969938902053 0.707749488187932 MirTarget;PITA -0.129704091431363 0.00672514393148887 NA NA NA hsa-let-7b-5p YEATS2 0.396604576702067 0.783406687058469 -0.222483738036726 0.696151760930445 miRNAWalker2_validate -0.11346229504823 0.000279989097581603 NA NA NA hsa-let-7b-3p YEATS4 0.314328399485033 0.684245834514538 0.264783448629143 0.545633543544553 MirTarget -0.191729448174963 4.23490356085628e-06 NA NA NA hsa-miR-214-5p YEATS4 0.413556552206067 0.383857606213638 0.264783448629143 0.545633543544553 MirTarget -0.142051407569401 1.13566562972979e-06 NA NA NA hsa-miR-128-3p YPEL3 -0.0364518492233463 0.95841670253784 0.324256878505045 0.587240846014544 MirTarget -0.162405783329563 0.00111144467217026 NA NA NA hsa-miR-320a YRDC 0.142884703798297 0.888511174254355 -0.0565298600851714 0.895218153000095 miRNAWalker2_validate -0.159809340148219 0.000106010250074959 NA NA NA hsa-miR-221-3p YWHAE -0.261179092929062 0.744019631321393 -0.019943826544063 0.980118976253723 miRNAWalker2_validate -0.136078622661566 7.164812533928e-05 NA NA NA hsa-miR-27a-3p YWHAQ 0.309634509674364 0.703724209648479 0.248025307198988 0.749614689250482 MirTarget -0.144203173756859 8.4184486648493e-06 NA NA NA hsa-miR-140-3p YWHAZ -0.105651799466207 0.9077781740714 0.188455985676775 0.829924368207083 MirTarget;PITA;miRNATAP -0.108331424167537 0.00687508798589382 NA NA NA hsa-miR-107 ZBED4 -0.289737369453023 0.769655185893943 0.00813327164822653 0.985062955812975 miRanda -0.134559246558153 0.000946504881860886 NA NA NA hsa-miR-17-5p ZBTB20 -0.643066792834501 0.320674049526638 -0.232424651957015 0.397193746246435 TargetScan -0.144914674008527 0.00352023092952584 NA NA NA hsa-miR-200b-3p ZBTB20 -0.532909690027328 0.555970111970307 -0.232424651957015 0.397193746246435 TargetScan -0.112754794755709 0.00870147100795866 NA NA NA hsa-miR-335-3p ZBTB20 0.0738544228922926 0.89349398283313 -0.232424651957015 0.397193746246435 mirMAP -0.150834782911828 0.000257520925415641 NA NA NA hsa-miR-362-5p ZBTB20 -0.35564884735017 0.452162806620853 -0.232424651957015 0.397193746246435 TargetScan -0.188001835589453 8.72512735146321e-07 NA NA NA hsa-miR-501-3p ZBTB20 0.272254003876544 0.713437785858009 -0.232424651957015 0.397193746246435 TargetScan -0.217834083061801 3.01373639560159e-08 NA NA NA hsa-miR-27a-3p ZBTB34 0.309634509674364 0.703724209648479 0.0114106620637942 0.976054394286673 MirTarget;miRNATAP -0.115629868416813 0.00181105875362378 NA NA NA hsa-miR-22-3p ZBTB39 0.0468440219945929 0.967778504781139 -0.163582166006159 0.689871027901515 MirTarget;miRNATAP -0.137355704231596 6.01182685340217e-05 NA NA NA hsa-miR-15b-5p ZBTB46 0.251826642099145 0.790709218602499 -0.363143239219536 0.46528615251256 MirTarget -0.147715737359592 0.0451715554129733 NA NA NA hsa-miR-98-5p ZBTB8B -0.0484028619275874 0.910781316485549 -0.292347035502569 0.518575141410114 MirTarget -0.21781442262593 0.0141796017422455 NA NA NA hsa-miR-15b-5p ZC3H12B 0.251826642099145 0.790709218602499 -0.361995898157424 0.218996761277024 miRNATAP -0.269062403624827 0.0025080741417027 NA NA NA hsa-miR-15b-5p ZC3H6 0.251826642099145 0.790709218602499 0.0664310878343275 0.862290500555547 miRNATAP -0.116155155821728 0.019327984486953 NA NA NA hsa-miR-107 ZC3H7B -0.289737369453023 0.769655185893943 -0.184910245519385 0.760413979417617 PITA;miRNATAP -0.137548287211035 0.000561000203282745 NA NA NA hsa-miR-15b-5p ZCCHC14 0.251826642099145 0.790709218602499 -0.053741999273627 0.913370762173496 miRNAWalker2_validate -0.194536395909898 0.000154488395125919 NA NA NA hsa-miR-150-5p ZDHHC22 -0.00683324482969283 0.994067057151257 0.132419503102911 0.828399656749994 MirTarget -0.240120646273261 0.00159870671357409 NA NA NA hsa-miR-15b-5p ZDHHC8 0.251826642099145 0.790709218602499 -0.357573835518696 0.491037220652071 mirMAP -0.120528540885123 0.0071252394530533 NA NA NA hsa-miR-128-3p ZEB1 -0.0364518492233463 0.95841670253784 0.174060806687355 0.660965127219402 MirTarget -0.148145642249719 0.0484532234152436 25921099 miR 128 modulates chemosensitivity and invasion of prostate cancer cells through targeting ZEB1 prostate cancer hsa-miR-15b-5p ZFHX3 0.251826642099145 0.790709218602499 -0.142657365419502 0.804712592221822 MirTarget;miRNATAP -0.202771041213214 0.000149012355864713 NA NA NA hsa-miR-98-5p ZFHX3 -0.0484028619275874 0.910781316485549 -0.142657365419502 0.804712592221822 miRNAWalker2_validate -0.144593173185827 2.2061113484391e-05 NA NA NA hsa-miR-107 ZFP28 -0.289737369453023 0.769655185893943 -0.179645714343375 0.573892458484186 miRanda -0.152236469747762 0.000826112892043404 NA NA NA hsa-miR-221-3p ZFP30 -0.261179092929062 0.744019631321393 -0.101958037580389 0.757912635004236 MirTarget -0.141773026205492 0.000482194159789366 NA NA NA hsa-miR-222-3p ZFP30 -0.233673471709747 0.726651775432807 -0.101958037580389 0.757912635004236 MirTarget -0.138075982291519 0.000614826239515209 NA NA NA hsa-miR-130b-3p ZFPM2 -0.246958204594817 0.524070870130445 -0.0254960086719236 0.956260690176495 miRNATAP -0.194973907610847 0.0310716347800662 NA NA NA hsa-miR-183-5p ZFPM2 -0.0462269171194745 0.969489414828393 -0.0254960086719236 0.956260690176495 miRNATAP -0.317277271063226 9.60530612920115e-08 NA NA NA hsa-miR-200a-3p ZFPM2 -0.801422367541981 0.147987649395985 -0.0254960086719236 0.956260690176495 miRNAWalker2_validate;miRTarBase -0.179017822616099 0.00826302679486245 26314828 It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 friend of GATA 2 which directly binds to the p85α regulatory subunit of PI3K lung cancer hsa-miR-200b-3p ZFPM2 -0.532909690027328 0.555970111970307 -0.0254960086719236 0.956260690176495 miRNAWalker2_validate;miRTarBase;TargetScan -0.231527314532215 0.000898301597612265 26314828 It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 friend of GATA 2 which directly binds to the p85α regulatory subunit of PI3K lung cancer hsa-miR-338-3p ZFPM2 -0.107178830331044 0.818042702366464 -0.0254960086719236 0.956260690176495 miRanda -0.149293723684794 0.0128347687337875 NA NA NA hsa-miR-375 ZFPM2 -0.989394125724925 0.312728638150002 -0.0254960086719236 0.956260690176495 miRanda -0.194069362609955 1.95170091998985e-06 NA NA NA hsa-miR-429 ZFPM2 -0.596617415946644 0.128967410286089 -0.0254960086719236 0.956260690176495 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.183304994813887 0.00815073708816067 NA NA NA hsa-miR-93-5p ZFPM2 -0.375078982324499 0.732311284477601 -0.0254960086719236 0.956260690176495 miRNATAP -0.261398665980377 0.00630915600364532 NA NA NA hsa-miR-222-3p ZFYVE16 -0.233673471709747 0.726651775432807 0.0693272997858037 0.873079183336731 miRNAWalker2_validate;MirTarget -0.10591064288812 0.000112239187819279 NA NA NA hsa-miR-22-3p ZFYVE9 0.0468440219945929 0.967778504781139 -0.160956630328475 0.734837632244252 MirTarget;miRNATAP -0.101503141425988 0.00357217891540455 NA NA NA hsa-miR-660-5p ZHX2 -0.561687438133488 0.138270972367544 -0.0711119628838031 0.904233146117601 miRNATAP -0.111137781594 0.00706756959731525 NA NA NA hsa-miR-15b-5p ZKSCAN1 0.251826642099145 0.790709218602499 -0.121348754645731 0.813844705222115 MirTarget;miRNATAP -0.132540726909147 0.00301086443780066 NA NA NA hsa-miR-15b-5p ZKSCAN2 0.251826642099145 0.790709218602499 -0.0662994595729716 0.839631344096541 miRNATAP -0.26762523761814 9.03949907992505e-07 NA NA NA hsa-miR-27a-3p ZKSCAN2 0.309634509674364 0.703724209648479 -0.0662994595729716 0.839631344096541 MirTarget;miRNATAP -0.13659360856057 0.00334444741509095 NA NA NA hsa-miR-15b-5p ZMIZ1 0.251826642099145 0.790709218602499 -0.324984978920388 0.643326015977664 mirMAP -0.117595999623936 0.044926413020511 NA NA NA hsa-miR-140-3p ZMYM3 -0.105651799466207 0.9077781740714 -0.190016685953795 0.760001693031918 PITA -0.10623474716025 0.00154329182507572 NA NA NA hsa-miR-23a-3p ZNF107 0.174045248211037 0.865717934161724 -0.104136306533658 0.767426189899497 MirTarget -0.178745717900392 9.17441174301364e-05 NA NA NA hsa-miR-23b-3p ZNF107 0.188949711826471 0.848360545615343 -0.104136306533658 0.767426189899497 MirTarget -0.222289503222549 6.60978996398453e-08 NA NA NA hsa-miR-146a-5p ZNF136 -0.129284021174742 0.817914855859866 0.172857493735338 0.640857719006538 MirTarget -0.11370469186487 3.85352770124082e-05 NA NA NA hsa-miR-192-5p ZNF184 -0.00281508349767456 0.99638352116085 -0.136905628197062 0.696547087088851 miRNAWalker2_validate -0.11017431750676 6.60275413556218e-05 NA NA NA hsa-miR-106a-5p ZNF217 -0.820057689616516 0.0254490146664247 0.048976454937609 0.941318134373159 MirTarget -0.102681307998652 0.00071306680981134 NA NA NA hsa-miR-130b-3p ZNF217 -0.246958204594817 0.524070870130445 0.048976454937609 0.941318134373159 miRNAWalker2_validate;MirTarget -0.101719005830084 0.0161944149728436 NA NA NA hsa-miR-17-5p ZNF217 -0.643066792834501 0.320674049526638 0.048976454937609 0.941318134373159 MirTarget;TargetScan -0.103031463519113 0.00655478910900329 NA NA NA hsa-miR-93-5p ZNF217 -0.375078982324499 0.732311284477601 0.048976454937609 0.941318134373159 miRNAWalker2_validate;MirTarget -0.117999624350587 0.0084959249519614 NA NA NA hsa-miR-140-3p ZNF226 -0.105651799466207 0.9077781740714 -0.0694838208185926 0.836934545600267 miRNATAP -0.103432502817957 0.0257271232713731 NA NA NA hsa-miR-181a-2-3p ZNF250 0.158138593715531 0.867246344226279 -0.14723338282547 0.747152859945718 mirMAP -0.13031410512691 0.00503772177659988 NA NA NA hsa-miR-219a-1-3p ZNF250 -0.385733322151236 0.345512422463289 -0.14723338282547 0.747152859945718 MirTarget -0.186059432440072 6.24987384860757e-06 NA NA NA hsa-miR-30a-3p ZNF250 0.11336767305191 0.920646436414994 -0.14723338282547 0.747152859945718 mirMAP -0.100058124365535 0.0150144965298495 NA NA NA hsa-miR-30e-3p ZNF250 0.202355073367528 0.857417040078429 -0.14723338282547 0.747152859945718 mirMAP -0.117540432884661 0.0405267564517898 NA NA NA hsa-miR-338-3p ZNF250 -0.107178830331044 0.818042702366464 -0.14723338282547 0.747152859945718 miRanda -0.135015918804693 4.94452104597865e-06 NA NA NA hsa-miR-539-5p ZNF250 0.551428040760553 0.139269787059339 -0.14723338282547 0.747152859945718 mirMAP -0.119970639216608 4.04323087415363e-05 NA NA NA hsa-miR-27a-3p ZNF329 0.309634509674364 0.703724209648479 -0.152487186391725 0.677687958890644 miRNATAP -0.130111798910533 0.000293467438336562 NA NA NA hsa-miR-128-3p ZNF34 -0.0364518492233463 0.95841670253784 -0.061187548230055 0.857976811756129 MirTarget -0.181088715963716 0.000799215077179787 NA NA NA hsa-miR-15b-5p ZNF346 0.251826642099145 0.790709218602499 0.00222459661969943 0.995217966941568 MirTarget -0.106491256694446 0.00825913281404265 NA NA NA hsa-miR-221-3p ZNF35 -0.261179092929062 0.744019631321393 -0.147138721044233 0.641516982915154 miRNAWalker2_validate -0.141413046695134 7.00337972035458e-07 NA NA NA hsa-miR-15b-5p ZNF362 0.251826642099145 0.790709218602499 -0.130498260842374 0.818096137664879 MirTarget;miRNATAP -0.147022929721132 0.000520595654746325 NA NA NA hsa-miR-15b-5p ZNF423 0.251826642099145 0.790709218602499 -0.516217270328072 0.316006276961565 miRNATAP -0.555582335047975 2.75746125325482e-06 NA NA NA hsa-miR-660-5p ZNF423 -0.561687438133488 0.138270972367544 -0.516217270328072 0.316006276961565 mirMAP -0.162471230549028 0.0255977494903126 NA NA NA hsa-let-7a-3p ZNF43 0.0395190175369595 0.888702137550015 0.0252666956744161 0.954025461161351 MirTarget -0.117824772376838 0.00651050970492668 NA NA NA hsa-let-7b-3p ZNF43 0.314328399485033 0.684245834514538 0.0252666956744161 0.954025461161351 MirTarget -0.182257204821913 0.000110840968889411 NA NA NA hsa-let-7f-1-3p ZNF43 0.131753980154284 0.686438107181988 0.0252666956744161 0.954025461161351 MirTarget -0.173698966953783 1.36668142316098e-05 NA NA NA hsa-miR-342-3p ZNF430 -0.233020179388453 0.739959578456401 -0.0873584395467479 0.772133307591171 miRNAWalker2_validate -0.115924841998867 0.00796673300481703 NA NA NA hsa-miR-150-5p ZNF474 -0.00683324482969283 0.994067057151257 0.0728479621534679 0.860881483641885 miRNATAP -0.206844977752837 0.000287997233099266 NA NA NA hsa-miR-139-5p ZNF493 -0.0625698939687087 0.914810329989088 -0.163705873013241 0.659115422678931 miRanda -0.116957325651717 0.0190426102031214 NA NA NA hsa-miR-150-5p ZNF497 -0.00683324482969283 0.994067057151257 -0.286690880356528 0.354397160401612 mirMAP -0.110407157094013 2.94494355108328e-05 NA NA NA hsa-miR-15b-5p ZNF516 0.251826642099145 0.790709218602499 -0.470735455819248 0.27234943977937 mirMAP -0.310519164852193 1.41504548968231e-05 NA NA NA hsa-miR-27a-3p ZNF516 0.309634509674364 0.703724209648479 -0.470735455819248 0.27234943977937 miRNATAP -0.170275689830132 0.00515287190516381 NA NA NA hsa-miR-107 ZNF526 -0.289737369453023 0.769655185893943 -0.146781809798395 0.724854271085581 miRanda -0.109518326463619 0.00680504659688886 NA NA NA hsa-miR-107 ZNF548 -0.289737369453023 0.769655185893943 -0.177788657191938 0.618757892054964 miRanda -0.12523154548983 0.00665769797830509 NA NA NA hsa-miR-27a-3p ZNF551 0.309634509674364 0.703724209648479 -0.16534888704788 0.612686772608162 miRNATAP -0.159375027891737 0.00062821786027445 NA NA NA hsa-miR-221-3p ZNF571 -0.261179092929062 0.744019631321393 0.0497049032203134 0.848396869591575 miRNAWalker2_validate -0.118044678096474 0.00140020885114666 NA NA NA hsa-miR-139-5p ZNF572 -0.0625698939687087 0.914810329989088 -0.26020482735682 0.414262119903553 miRanda -0.20602632870199 9.92505787261402e-06 NA NA NA hsa-miR-107 ZNF582 -0.289737369453023 0.769655185893943 -0.196399106982681 0.431515528668 miRanda -0.160003976076588 0.0172181800411512 NA NA NA hsa-miR-107 ZNF586 -0.289737369453023 0.769655185893943 0.116010952283571 0.748982901937019 miRanda -0.181741392971122 0.00314572973099908 NA NA NA hsa-miR-107 ZNF606 -0.289737369453023 0.769655185893943 -0.316700326216714 0.421136942847005 MirTarget;miRanda -0.135160081599711 0.00706415562126044 NA NA NA hsa-miR-221-3p ZNF615 -0.261179092929062 0.744019631321393 -0.190081725102292 0.568922799331231 MirTarget -0.128023044267788 0.000698754311188927 NA NA NA hsa-miR-222-3p ZNF615 -0.233673471709747 0.726651775432807 -0.190081725102292 0.568922799331231 MirTarget -0.145060358352778 0.000102933410421809 NA NA NA hsa-miR-148a-3p ZNF618 -0.324144803192141 0.746264759480212 -0.228170793453136 0.681019696295386 miRNATAP -0.119182834639632 0.0015437769851201 NA NA NA hsa-miR-27a-3p ZNF620 0.309634509674364 0.703724209648479 -0.231633792805832 0.333314454766449 miRNATAP -0.101512960995742 0.0168817692521744 NA NA NA hsa-miR-29b-2-5p ZNF623 -0.0876372630441624 0.860453852037775 -0.161915532800684 0.745763189410927 mirMAP -0.104379929031592 0.0107085882480077 NA NA NA hsa-miR-92b-3p ZNF623 0.454620627632174 0.646193882241421 -0.161915532800684 0.745763189410927 mirMAP -0.133081719609301 2.58282749871538e-05 NA NA NA hsa-miR-150-5p ZNF625 -0.00683324482969283 0.994067057151257 -0.147746665810466 0.567169604897836 MirTarget -0.138104873254005 1.12834218235469e-05 NA NA NA hsa-miR-15b-5p ZNF629 0.251826642099145 0.790709218602499 -0.0571001080673312 0.915144368514333 miRNATAP -0.109740229862676 0.00709794820934456 NA NA NA hsa-miR-139-5p ZNF649 -0.0625698939687087 0.914810329989088 -0.373262166208389 0.360089836968903 miRanda -0.127425723345727 0.0046562629244197 NA NA NA hsa-miR-148a-3p ZNF665 -0.324144803192141 0.746264759480212 -0.341961699914061 0.0953075560421861 MirTarget -0.100828271734996 0.0226886221877474 NA NA NA hsa-miR-222-3p ZNF670 -0.233673471709747 0.726651775432807 -0.0263697859161081 0.915187056498908 MirTarget -0.161943499883303 2.76079872624483e-05 NA NA NA hsa-miR-140-3p ZNF677 -0.105651799466207 0.9077781740714 -0.0721312232159022 0.797589719352189 miRNATAP -0.130125689993841 0.04580415383857 NA NA NA hsa-miR-320a ZNF688 0.142884703798297 0.888511174254355 0.17888405587203 0.601710613306065 miRanda -0.13202753987523 0.00155903382784565 NA NA NA hsa-miR-15b-5p ZNF697 0.251826642099145 0.790709218602499 -0.214799172094718 0.467404565876675 miRNATAP -0.267998444709203 3.13311306252704e-05 NA NA NA hsa-miR-129-5p ZNF7 0.417083435812871 0.454236109516901 -0.105811602790789 0.830078908542865 miRanda -0.111475259218231 1.3435671665644e-06 NA NA NA hsa-miR-222-3p ZNF708 -0.233673471709747 0.726651775432807 -0.14711225703798 0.638757303296248 miRNAWalker2_validate -0.155817001775589 6.69323539367133e-05 NA NA NA hsa-miR-150-5p ZNF711 -0.00683324482969283 0.994067057151257 -0.514937480773065 0.206818328957412 MirTarget -0.133649071820439 0.00748769435785501 NA NA NA hsa-miR-222-3p ZNF714 -0.233673471709747 0.726651775432807 -0.387983613882369 0.354260530373851 miRNAWalker2_validate -0.15313831122813 0.00432546178709457 NA NA NA hsa-miR-140-3p ZNF768 -0.105651799466207 0.9077781740714 -0.0769612496588907 0.889494562283885 miRNATAP -0.1140247755252 0.000167579323105299 NA NA NA hsa-miR-140-3p ZNF772 -0.105651799466207 0.9077781740714 -0.186151174166256 0.641668520513098 MirTarget -0.219175047633655 0.000822371707557344 NA NA NA hsa-miR-27a-3p ZNF780B 0.309634509674364 0.703724209648479 -0.172233406638922 0.633340872368802 MirTarget -0.14656965233442 0.00361072844124561 NA NA NA hsa-miR-139-5p ZNF792 -0.0625698939687087 0.914810329989088 -0.0191568196200911 0.949879224812413 MirTarget;miRanda -0.10006566936654 0.0194314180921909 NA NA NA hsa-miR-107 ZNF880 -0.289737369453023 0.769655185893943 -0.384322049393129 0.272857154493702 miRanda -0.246431932375037 0.000482886720170941 NA NA NA hsa-miR-221-3p ZNF93 -0.261179092929062 0.744019631321393 -0.108309927074221 0.764257061373746 MirTarget -0.188909267734001 8.71198929266268e-05 NA NA NA hsa-miR-222-3p ZNF93 -0.233673471709747 0.726651775432807 -0.108309927074221 0.764257061373746 MirTarget -0.187177092528949 8.90837949452485e-05 NA NA NA hsa-miR-107 ZSCAN22 -0.289737369453023 0.769655185893943 -0.162184979360733 0.578367908826222 miRanda -0.104418616594854 0.018139271690049 NA NA NA hsa-miR-15b-5p ZSWIM3 0.251826642099145 0.790709218602499 0.163008932312042 0.541898936609333 MirTarget;miRNATAP -0.102139703568939 0.00781097436271043 NA NA NA hsa-miR-26b-5p ZWINT 0.16143906971203 0.790777916193478 0.253768182988161 0.575523570939568 miRNAWalker2_validate -0.171914822938807 0.00802434846061747 NA NA NA