miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-106a-5p	TGFBR2	0.574594373206545	0.000145868284001732	-2.39529308737339	4.9899056025782e-85	miRTarBase;miRNATAP	-0.167004125374202	5.11178559030175e-08	22912877	MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion	cell migration	colorectal cancer
hsa-miR-106b-5p	TGFBR2	1.22477789913175	2.31787213143326e-32	-2.39529308737339	4.9899056025782e-85	miRNATAP	-0.583213497349775	2.44964235169299e-45		NA	NA	NA
hsa-miR-107	TGFBR2	0.678998026350662	2.56224148930538e-16	-2.39529308737339	4.9899056025782e-85	miRanda;miRNATAP	-0.530917906321599	1.66581882091816e-22		NA	NA	NA
hsa-miR-130b-3p	TGFBR2	1.38122163823846	1.00932179737836e-26	-2.39529308737339	4.9899056025782e-85	miRNAWalker2_validate;miRNATAP	-0.355697993280506	3.73635681408915e-25	25024357	Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC		lung squamous cell cancer
hsa-miR-17-5p	TGFBR2	0.599531757298529	1.07318660415906e-05	-2.39529308737339	4.9899056025782e-85	miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP	-0.344837157501155	3.26279419912174e-25	25011053;27120811	We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer	;	kidney renal cell cancer;gastric cancer
hsa-miR-18a-5p	TGFBR2	0.969066793715868	1.69069796425892e-08	-2.39529308737339	4.9899056025782e-85	miRNAWalker2_validate	-0.233316456798081	1.26332307500906e-18		NA	NA	NA
hsa-miR-19a-3p	TGFBR2	0.817507952171848	3.76285090469625e-08	-2.39529308737339	4.9899056025782e-85	miRNAWalker2_validate;miRNATAP	-0.295433323573397	3.17340161137166e-22		NA	NA	NA
hsa-miR-19b-3p	TGFBR2	0.139124391010031	0.255658553872934	-2.39529308737339	4.9899056025782e-85	miRNAWalker2_validate;miRNATAP	-0.23529469963531	5.83073772392392e-10		NA	NA	NA
hsa-miR-20a-5p	TGFBR2	0.44979911120222	0.000602386964327228	-2.39529308737339	4.9899056025782e-85	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.346418250547717	1.79003902635661e-23		NA	NA	NA
hsa-miR-20b-5p	TGFBR2	0.78236583455125	8.7938334801223e-05	-2.39529308737339	4.9899056025782e-85	miRNATAP	-0.101055475114644	1.4278146071271e-05		NA	NA	NA
hsa-miR-21-5p	TGFBR2	2.32007501846389	3.08394781855554e-137	-2.39529308737339	4.9899056025782e-85	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.537594809270263	3.47307989185754e-40	24037531	Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway		prostate cancer
hsa-miR-301a-3p	TGFBR2	1.32170168375632	2.12280368957514e-15	-2.39529308737339	4.9899056025782e-85	miRNATAP	-0.317266296975964	1.73201531962553e-32	25551793	MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2		colorectal cancer
hsa-miR-320b	TGFBR2	0.412787504747938	0.00113457276903985	-2.39529308737339	4.9899056025782e-85	miRanda;miRNATAP	-0.208017816637935	1.58734456312155e-08		NA	NA	NA
hsa-miR-340-5p	TGFBR2	1.0857159627596	4.94471062546756e-24	-2.39529308737339	4.9899056025782e-85	mirMAP	-0.314168975517319	6.41119882395371e-14		NA	NA	NA
hsa-miR-429	TGFBR2	2.84108892259147	3.88520896426515e-64	-2.39529308737339	4.9899056025782e-85	miRNATAP	-0.404995702801572	1.14853648012577e-64		NA	NA	NA
hsa-miR-454-3p	TGFBR2	1.28177672191095	6.84024979484587e-21	-2.39529308737339	4.9899056025782e-85	miRNATAP	-0.384614615164931	1.36686238358356e-32		NA	NA	NA
hsa-miR-590-3p	TGFBR2	1.27438512890514	1.03164723481469e-23	-2.39529308737339	4.9899056025782e-85	miRanda	-0.338025545666787	3.04278770804611e-20		NA	NA	NA
hsa-miR-590-5p	TGFBR2	0.746515607868274	8.51300479640125e-09	-2.39529308737339	4.9899056025782e-85	miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP	-0.286652524899627	4.12566791851325e-16		NA	NA	NA
hsa-miR-9-5p	TGFBR2	0.734772328078424	0.00261982843636383	-2.39529308737339	4.9899056025782e-85	miRNATAP	-0.11967052909348	2.52866655443074e-10	25024357	Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC		lung squamous cell cancer
hsa-miR-92a-3p	TGFBR2	-0.342420481092807	0.000732275969501111	-2.39529308737339	4.9899056025782e-85	miRNAWalker2_validate	-0.223515332507838	1.18491745689284e-06		NA	NA	NA
hsa-miR-93-5p	TGFBR2	1.01788600209314	1.24312921618126e-21	-2.39529308737339	4.9899056025782e-85	miRNAWalker2_validate;miRNATAP	-0.609999323446729	8.30075605455623e-52		NA	NA	NA