miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-224-5p	ABCC5	-2.65799597897592	2.73629620293273e-08	0.673807010877841	0.219624220061263	mirMAP	-0.119218322824553	3.91866151312107e-14		NA	NA	NA
hsa-miR-224-5p	ABHD2	-2.65799597897592	2.73629620293273e-08	1.06012917170319	0.12031120252338	mirMAP	-0.144890787859168	1.48807898446435e-17		NA	NA	NA
hsa-miR-452-5p	ABHD2	-2.0200941872388	0.000263136484394317	1.06012917170319	0.12031120252338	mirMAP	-0.224241055461649	7.16006489917389e-29		NA	NA	NA
hsa-miR-18a-5p	ABR	-2.29585803678176	4.139318990016e-14	0.312559475376877	0.602777794967167	miRNAWalker2_validate;mirMAP	-0.109068853724789	3.43667008155402e-21		NA	NA	NA
hsa-miR-224-5p	ACSS1	-2.65799597897592	2.73629620293273e-08	0.508393362085299	0.33926218057204	MirTarget	-0.157750641392094	3.01905897900621e-23		NA	NA	NA
hsa-miR-452-5p	ACSS1	-2.0200941872388	0.000263136484394317	0.508393362085299	0.33926218057204	MirTarget	-0.159593675143779	1.1341340298918e-16		NA	NA	NA
hsa-miR-18a-5p	ADAMTS2	-2.29585803678176	4.139318990016e-14	0.286300677747046	0.511667136335646	mirMAP	-0.151270479965282	2.23092352991542e-06		NA	NA	NA
hsa-miR-224-5p	AFF3	-2.65799597897592	2.73629620293273e-08	4.00469653102997	7.69598041725568e-12	MirTarget	-0.489480339393867	2.56887683469959e-41		NA	NA	NA
hsa-miR-18a-5p	AFF4	-2.29585803678176	4.139318990016e-14	0.703872124755367	0.275601125831837	miRNAWalker2_validate	-0.216780642407195	5.47601743907678e-38		NA	NA	NA
hsa-miR-224-5p	AGBL4	-2.65799597897592	2.73629620293273e-08	1.65365559191252	5.90807224710315e-10	mirMAP	-0.198611630941492	1.20975038620724e-15		NA	NA	NA
hsa-miR-18a-5p	ALCAM	-2.29585803678176	4.139318990016e-14	1.44213442376849	0.0323015123311927	MirTarget;miRNATAP	-0.342138218282154	4.63746773220129e-31		NA	NA	NA
hsa-miR-224-5p	AMN1	-2.65799597897592	2.73629620293273e-08	0.476380700625545	0.123405009174543	MirTarget	-0.111268441586752	3.05831977893753e-24		NA	NA	NA
hsa-miR-224-5p	AMZ1	-2.65799597897592	2.73629620293273e-08	1.47106045019316	2.87845499447138e-07	mirMAP	-0.22949697878475	2.13832188108332e-12		NA	NA	NA
hsa-miR-18a-5p	ANKRD50	-2.29585803678176	4.139318990016e-14	0.731171419106682	0.176754074331242	MirTarget;miRNATAP	-0.177741763059093	2.01514957148336e-16		NA	NA	NA
hsa-miR-452-5p	ANKS1B	-2.0200941872388	0.000263136484394317	1.35978918186109	3.06791627628135e-08	miRNATAP	-0.292490270164633	5.74850826027726e-33		NA	NA	NA
hsa-miR-18a-5p	APOLD1	-2.29585803678176	4.139318990016e-14	0.37633524726824	0.452099926727469	mirMAP	-0.158264613633656	3.21161314972337e-09		NA	NA	NA
hsa-miR-18a-5p	ARFGEF2	-2.29585803678176	4.139318990016e-14	0.403974847064544	0.505750315604731	MirTarget	-0.121111361663676	9.26771791125924e-12		NA	NA	NA
hsa-miR-18a-5p	ARHGAP5	-2.29585803678176	4.139318990016e-14	0.0467432865023154	0.935128459476299	MirTarget	-0.116582874797694	7.2816059600348e-10		NA	NA	NA
hsa-miR-452-5p	ARID2	-2.0200941872388	0.000263136484394317	0.689032777719507	0.162315918962125	MirTarget	-0.139877448467592	5.44443512586762e-32		NA	NA	NA
hsa-miR-18a-5p	ARL15	-2.29585803678176	4.139318990016e-14	0.824504347980592	0.0221666285037988	MirTarget;miRNATAP	-0.256659599347071	8.53689264458731e-32		NA	NA	NA
hsa-miR-224-5p	ARMCX2	-2.65799597897592	2.73629620293273e-08	0.49786403194237	0.332069412312774	MirTarget	-0.110254447297717	1.02544664704834e-12		NA	NA	NA
hsa-miR-452-5p	ASAH1	-2.0200941872388	0.000263136484394317	0.997361531115903	0.17530777766717	MirTarget	-0.1019250046905	2.00296746116993e-08		NA	NA	NA
hsa-miR-18a-5p	ASTN1	-2.29585803678176	4.139318990016e-14	-0.108687925237062	0.731194094181717	MirTarget	-0.24658682628591	3.80944772672986e-06		NA	NA	NA
hsa-miR-18a-5p	ASXL2	-2.29585803678176	4.139318990016e-14	0.0411968235596722	0.921956173643722	miRNATAP	-0.172959671290264	8.68420972604786e-09		NA	NA	NA
hsa-miR-18a-5p	ATF7	-2.29585803678176	4.139318990016e-14	0.314214952901343	0.577417375663341	mirMAP	-0.135353522649776	2.5614664515906e-27		NA	NA	NA
hsa-miR-18a-5p	ATM	-2.29585803678176	4.139318990016e-14	0.0493046365018301	0.923235059785624	miRNAWalker2_validate;miRTarBase;MirTarget	-0.116309277677122	3.16867464269194e-11	23857602;23437304;25963391;23229340	Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases	;;;progression	breast cancer;colorectal cancer;cervical and endocervical cancer;colon cancer
hsa-miR-18a-5p	ATP1B2	-2.29585803678176	4.139318990016e-14	0.534070926473392	0.0104546738251564	mirMAP	-0.227686734467817	6.54947879295752e-15		NA	NA	NA
hsa-miR-18a-5p	ATP2B1	-2.29585803678176	4.139318990016e-14	0.318945553342943	0.54339624045494	miRNATAP	-0.120983732791358	3.71397545202766e-12		NA	NA	NA
hsa-miR-18a-5p	ATP2C2	-2.29585803678176	4.139318990016e-14	0.98892887747084	0.0117017545691765	MirTarget	-0.198572649927767	5.57829579300383e-07		NA	NA	NA
hsa-miR-18a-5p	ATXN1	-2.29585803678176	4.139318990016e-14	0.476138919679845	0.351257844473468	MirTarget;miRNATAP	-0.158757938966941	9.08602732129693e-23		NA	NA	NA
hsa-miR-18a-5p	BBX	-2.29585803678176	4.139318990016e-14	0.0588524416015161	0.916540577808447	MirTarget;miRNATAP	-0.107164441129034	1.56844778188935e-10		NA	NA	NA
hsa-miR-452-5p	BCAS1	-2.0200941872388	0.000263136484394317	4.84639733592195	2.71035483325206e-26	mirMAP	-0.653153229792534	1.33230017711067e-41		NA	NA	NA
hsa-miR-224-5p	BCL2	-2.65799597897592	2.73629620293273e-08	1.87954010585123	0.000984341696950829	mirMAP	-0.241222882395465	2.18051025428057e-28	24796455	In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01		gastric cancer
hsa-miR-452-5p	BCL2	-2.0200941872388	0.000263136484394317	1.87954010585123	0.000984341696950829	mirMAP	-0.281160548783898	1.07099917549241e-26		NA	NA	NA
hsa-miR-18a-5p	BHLHE22	-2.29585803678176	4.139318990016e-14	-0.389932241284234	0.0480957043662165	MirTarget;miRNATAP	-0.102847395049489	0.00101179851804635		NA	NA	NA
hsa-miR-224-5p	BTRC	-2.65799597897592	2.73629620293273e-08	0.934469346915097	0.0578416424166956	MirTarget	-0.132498017840424	7.27857382043359e-34		NA	NA	NA
hsa-miR-452-5p	BZW1	-2.0200941872388	0.000263136484394317	0.466156121660794	0.519278178839634	MirTarget;miRNATAP	-0.111180268401706	1.30030158068662e-23		NA	NA	NA
hsa-miR-18a-5p	C1orf21	-2.29585803678176	4.139318990016e-14	1.3116600895155	0.0376338055321082	mirMAP	-0.352380566715628	9.90850405457288e-39		NA	NA	NA
hsa-miR-224-5p	C1orf21	-2.65799597897592	2.73629620293273e-08	1.3116600895155	0.0376338055321082	mirMAP	-0.131615319233814	2.72070911390545e-12		NA	NA	NA
hsa-miR-452-5p	C1orf21	-2.0200941872388	0.000263136484394317	1.3116600895155	0.0376338055321082	mirMAP	-0.130567596630495	9.17294610895604e-09		NA	NA	NA
hsa-miR-18a-5p	C1orf226	-2.29585803678176	4.139318990016e-14	0.837998926190791	0.0862808022528826	mirMAP	-0.288803056276439	1.14096045122522e-18		NA	NA	NA
hsa-miR-18a-5p	C5orf30	-2.29585803678176	4.139318990016e-14	1.63731454024135	0.000352852418461725	miRNATAP	-0.221817652321724	1.71205775534449e-21		NA	NA	NA
hsa-miR-18a-5p	CA12	-2.29585803678176	4.139318990016e-14	4.60824015441829	2.6722328864236e-10	miRNAWalker2_validate;MirTarget	-0.845217777323844	1.2280252750954e-70		NA	NA	NA
hsa-miR-18a-5p	CACNG4	-2.29585803678176	4.139318990016e-14	3.35808733108355	1.01411652848366e-09	mirMAP	-0.479660977852052	1.65065818706956e-15		NA	NA	NA
hsa-miR-224-5p	CADM2	-2.65799597897592	2.73629620293273e-08	2.36354384514459	1.18875938460695e-12	mirMAP	-0.163386837056061	1.0673293905645e-05		NA	NA	NA
hsa-miR-452-5p	CADM2	-2.0200941872388	0.000263136484394317	2.36354384514459	1.18875938460695e-12	MirTarget	-0.127988416533862	0.00422312676275801		NA	NA	NA
hsa-miR-18a-5p	CALN1	-2.29585803678176	4.139318990016e-14	1.13844791757	0.00177546409753964	mirMAP	-0.423327540543552	1.61797555803963e-16		NA	NA	NA
hsa-miR-18a-5p	CAMK2B	-2.29585803678176	4.139318990016e-14	1.555594885724	1.35370226826515e-06	mirMAP	-0.272652665944852	5.85107409807785e-08		NA	NA	NA
hsa-miR-18a-5p	CAMK2N1	-2.29585803678176	4.139318990016e-14	1.68564190240764	0.00250869030556963	miRNATAP	-0.297143132124591	5.13523150174157e-24		NA	NA	NA
hsa-miR-452-5p	CASC1	-2.0200941872388	0.000263136484394317	2.5594283466148	1.38668898218654e-27	MirTarget	-0.445159797294547	6.93699779838269e-47		NA	NA	NA
hsa-miR-452-5p	CASD1	-2.0200941872388	0.000263136484394317	0.964032593316181	0.0532895733579082	MirTarget;miRNATAP	-0.164718496792201	1.33308009021733e-19		NA	NA	NA
hsa-miR-18a-5p	CASZ1	-2.29585803678176	4.139318990016e-14	0.876955493153372	0.0913968455267192	mirMAP	-0.224148052389293	1.08753977757912e-28		NA	NA	NA
hsa-miR-224-5p	CCNG2	-2.65799597897592	2.73629620293273e-08	1.09319477992261	0.0786773462384456	mirMAP	-0.124461718628112	3.77609224120173e-21		NA	NA	NA
hsa-miR-452-5p	CCNO	-2.0200941872388	0.000263136484394317	1.96634258261622	5.14514034717357e-07	MirTarget	-0.268606219050328	1.76413182280284e-08		NA	NA	NA
hsa-miR-452-5p	CDH2	-2.0200941872388	0.000263136484394317	0.0272179144912426	0.917351510596282	miRNATAP	-0.138218625809158	3.98822584108841e-05		NA	NA	NA
hsa-miR-18a-5p	CDON	-2.29585803678176	4.139318990016e-14	0.932755250435237	0.03700963861363	mirMAP	-0.269832410713206	2.46101550483186e-23		NA	NA	NA
hsa-miR-452-5p	CDON	-2.0200941872388	0.000263136484394317	0.932755250435237	0.03700963861363	mirMAP	-0.105461800597006	2.43148112170672e-06		NA	NA	NA
hsa-miR-18a-5p	CLASP2	-2.29585803678176	4.139318990016e-14	0.437673296089149	0.39581135060193	miRNATAP	-0.144015352857882	3.91095997033606e-25		NA	NA	NA
hsa-miR-224-5p	COQ7	-2.65799597897592	2.73629620293273e-08	0.867106757225216	0.0465993407958145	mirMAP	-0.114022110328958	1.59412853881212e-35		NA	NA	NA
hsa-miR-18a-5p	CREBL2	-2.29585803678176	4.139318990016e-14	0.549328377929986	0.345694685390556	miRNAWalker2_validate;MirTarget;miRNATAP	-0.18688020696653	6.39009893275456e-46		NA	NA	NA
hsa-miR-18a-5p	CRIM1	-2.29585803678176	4.139318990016e-14	0.308528041669781	0.634297036399115	MirTarget;miRNATAP	-0.268538776483512	4.74205100277358e-24		NA	NA	NA
hsa-miR-452-5p	CSMD3	-2.0200941872388	0.000263136484394317	1.20233877602647	0.0346078529581124	MirTarget	-0.222265774672966	3.51928131100354e-06		NA	NA	NA
hsa-miR-18a-5p	CSNK1G1	-2.29585803678176	4.139318990016e-14	0.461828350171912	0.313055865644168	mirMAP	-0.107632067902284	2.58794384497738e-15		NA	NA	NA
hsa-miR-18a-5p	CSRNP3	-2.29585803678176	4.139318990016e-14	0.299105566944236	0.371187975460309	miRNAWalker2_validate;miRNATAP	-0.362405771137282	3.19672029425217e-15		NA	NA	NA
hsa-miR-452-5p	CST1	-2.0200941872388	0.000263136484394317	1.36020216083415	0.00826490066984338	MirTarget	-0.670093357802353	1.81952329773778e-20		NA	NA	NA
hsa-miR-452-5p	CST5	-2.0200941872388	0.000263136484394317	3.37394967327104	2.03483092750853e-08	MirTarget	-0.752071633068046	1.05784681317653e-30		NA	NA	NA
hsa-miR-18a-5p	CTDSPL	-2.29585803678176	4.139318990016e-14	0.406212474550547	0.460806418428075	miRNAWalker2_validate;MirTarget;miRNATAP	-0.158588848975107	3.51928970904997e-32		NA	NA	NA
hsa-miR-18a-5p	CTGF	-2.29585803678176	4.139318990016e-14	0.215367037595755	0.781176358373924	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.119846814285957	2.0448230920207e-05	23249750	Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling	poor survival	glioblastoma
hsa-miR-224-5p	CXXC4	-2.65799597897592	2.73629620293273e-08	1.30769268523275	5.95588414495965e-07	MirTarget	-0.181942353850854	3.60612131804488e-12		NA	NA	NA
hsa-miR-452-5p	CXXC4	-2.0200941872388	0.000263136484394317	1.30769268523275	5.95588414495965e-07	miRNATAP	-0.234320108333777	8.18417899337699e-14		NA	NA	NA
hsa-miR-18a-5p	CYP4F11	-2.29585803678176	4.139318990016e-14	2.83072267551312	1.17177976552718e-13	MirTarget	-0.608616466590783	3.56154348444121e-22		NA	NA	NA
hsa-miR-18a-5p	DAAM2	-2.29585803678176	4.139318990016e-14	0.0402745144958074	0.924877679800937	miRNAWalker2_validate	-0.128936539387179	3.13505694340858e-06		NA	NA	NA
hsa-miR-452-5p	DACH1	-2.0200941872388	0.000263136484394317	4.04866918627824	9.79741263930409e-20	mirMAP	-0.511118870941053	3.69161116107759e-34		NA	NA	NA
hsa-miR-452-5p	DCTN4	-2.0200941872388	0.000263136484394317	0.762752155416791	0.197705482106988	mirMAP	-0.118497444081383	2.55654391701999e-31		NA	NA	NA
hsa-miR-18a-5p	DCUN1D3	-2.29585803678176	4.139318990016e-14	0.211621277631069	0.504175374129796	miRNAWalker2_validate	-0.11981287755687	3.22327193832774e-17		NA	NA	NA
hsa-miR-452-5p	DENND1B	-2.0200941872388	0.000263136484394317	0.37154891360025	0.196687804704217	mirMAP	-0.152305894689517	2.32121803201617e-08		NA	NA	NA
hsa-miR-452-5p	DHX40	-2.0200941872388	0.000263136484394317	0.612148339652061	0.276094538922265	MirTarget	-0.105700081834879	2.88499446259358e-16		NA	NA	NA
hsa-miR-18a-5p	DICER1	-2.29585803678176	4.139318990016e-14	0.296736937053202	0.609130672882288	miRNAWalker2_validate	-0.136912050395007	2.01038095738162e-17	27338043;21935572	MiR 18a upregulation decreases Dicer expression and confers paclitaxel resistance in triple negative breast cancer; In this study we investigated the association among miR-18a dysregulation Dicer dysregulation and paclitaxel PTX resistance in TNBC cells; The influence of miR-18a overexpression on Dicer expression was measured by qRT-PCR and Western blot analysis; MiR-18a overexpression directly led to Dicer repression at mRNA and protein level; This study found that miR-18a is an important miRNA that suppresses Dicer expression and increases PTX resistance in TNBC cells;microRNA 18a a member of the oncogenic miR 17 92 cluster targets Dicer and suppresses cell proliferation in bladder cancer T24 cells; Furthermore ectopic expression of miR-18a in T24 cells down-regulated Dicer expression at both the mRNA and protein level while inhibition miR-18a by antisense oligonucleotides could enhance Dicer expression in T24 cells; Two binding sites of miR-18a were found in Dicer 3' untranslated region 3' UTR; In addition knockdown of Dicer expression by siRNA mimicked cell growth suppression induced by miR-18a in T24 cells; These results show that miR-18a functions as a tumor suppressor by targeting Dicer in bladder cancer T24 cells and revealed a noteworthy feedback loop which may be utilized by the miR-17-92 cluster to control miRNA output and prevent its overexpression	drug resistance;	breast cancer;bladder cancer
hsa-miR-224-5p	DIO1	-2.65799597897592	2.73629620293273e-08	3.83209753849657	3.3105622583002e-21	miRTarBase	-0.352294553302583	1.05750240342598e-13		NA	NA	NA
hsa-miR-18a-5p	DNAJC16	-2.29585803678176	4.139318990016e-14	0.57291606856762	0.217738123971802	MirTarget	-0.154106968328649	2.07514991406951e-34		NA	NA	NA
hsa-miR-224-5p	DNMBP	-2.65799597897592	2.73629620293273e-08	1.13995808178306	0.0156986765255131	MirTarget	-0.125485470035184	4.67208389056604e-16		NA	NA	NA
hsa-miR-18a-5p	DOCK4	-2.29585803678176	4.139318990016e-14	-0.0682252033258592	0.864672472175754	MirTarget	-0.105041741749793	1.36108409679642e-07		NA	NA	NA
hsa-miR-18a-5p	DPY19L3	-2.29585803678176	4.139318990016e-14	0.541752254913417	0.157107066790333	MirTarget	-0.1842473421487	2.56869719979074e-14		NA	NA	NA
hsa-miR-452-5p	DPY19L3	-2.0200941872388	0.000263136484394317	0.541752254913417	0.157107066790333	mirMAP	-0.117439046099718	2.24379131512582e-09		NA	NA	NA
hsa-miR-18a-5p	DST	-2.29585803678176	4.139318990016e-14	-0.0159871038958483	0.982364261487706	mirMAP	-0.253594711302634	1.70338130586849e-17		NA	NA	NA
hsa-miR-452-5p	DUSP4	-2.0200941872388	0.000263136484394317	1.64593674356733	0.00224163156983004	mirMAP	-0.168546342430895	8.96343246877319e-08		NA	NA	NA
hsa-miR-224-5p	EFR3B	-2.65799597897592	2.73629620293273e-08	0.907617945234242	0.00160814731101223	MirTarget	-0.165720644300769	1.97418407967108e-15		NA	NA	NA
hsa-miR-452-5p	ELAVL2	-2.0200941872388	0.000263136484394317	-1.04494192551406	5.07725223320213e-05	MirTarget;miRNATAP	-0.137355130969077	0.000121853179990045		NA	NA	NA
hsa-miR-452-5p	ELFN2	-2.0200941872388	0.000263136484394317	1.35652934571904	4.74466394964518e-05	miRNATAP	-0.101606338660021	0.0126173282075685		NA	NA	NA
hsa-miR-452-5p	ELOVL5	-2.0200941872388	0.000263136484394317	1.45482712616055	0.0504910697351892	MirTarget	-0.157729717826227	3.0532743155437e-14		NA	NA	NA
hsa-miR-452-5p	ERBB4	-2.0200941872388	0.000263136484394317	5.37185314288959	2.30708721608421e-25	mirMAP	-0.701884213446386	2.37990608843616e-40		NA	NA	NA
hsa-miR-18a-5p	ESR1	-2.29585803678176	4.139318990016e-14	6.14976130956366	3.35739499466105e-17	miRNAWalker2_validate;miRTarBase;miRNATAP	-1.14044745041939	3.5647791599912e-74	19027010;24975878	MicroRNA 18a prevents estrogen receptor alpha expression promoting proliferation of hepatocellular carcinoma cells; The gene ESR1 which encodes the estrogen receptor-alpha ERalpha was identified as a target of miR-18a miR-18a can repress ERalpha translation by binding to its mRNA at the 3' untranslated region;Elevated p53 promotes the processing of miR 18a to decrease estrogen receptor α in female hepatocellular carcinoma; Our previous study identified that estrogen receptor alpha ERα protein is downregulated in 60% of female HCC cases via a miR-18a elevation mediated suppression of ERα translation	;	liver cancer;liver cancer
hsa-miR-18a-5p	F3	-2.29585803678176	4.139318990016e-14	0.069173953948714	0.882405693197853	MirTarget	-0.22259238842336	5.95650101731875e-11		NA	NA	NA
hsa-miR-18a-5p	FAIM2	-2.29585803678176	4.139318990016e-14	1.17062084953123	0.00019830853854021	mirMAP	-0.36753895081149	1.06119137499698e-14		NA	NA	NA
hsa-miR-224-5p	FAM135B	-2.65799597897592	2.73629620293273e-08	2.43135181508455	2.06009646343704e-11	MirTarget	-0.30557314375627	1.42552693168215e-16		NA	NA	NA
hsa-miR-18a-5p	FAM166B	-2.29585803678176	4.139318990016e-14	0.211517423149237	0.426848124792192	MirTarget	-0.142348737056905	0.00112263071949073		NA	NA	NA
hsa-miR-18a-5p	FAM168A	-2.29585803678176	4.139318990016e-14	0.0384355950528388	0.907350068947121	mirMAP	-0.123229308838653	5.4509195026933e-07		NA	NA	NA
hsa-miR-224-5p	FAM177B	-2.65799597897592	2.73629620293273e-08	1.40205918340045	0.000230549360472132	MirTarget	-0.147577787915589	1.74114361496924e-05		NA	NA	NA
hsa-miR-18a-5p	FAM196A	-2.29585803678176	4.139318990016e-14	2.85680700789912	4.07793226917649e-15	MirTarget	-0.558344683915752	1.52927869844399e-19		NA	NA	NA
hsa-miR-452-5p	FAM196A	-2.0200941872388	0.000263136484394317	2.85680700789912	4.07793226917649e-15	mirMAP	-0.61021539959501	6.07189040503729e-36		NA	NA	NA
hsa-miR-224-5p	FAM46C	-2.65799597897592	2.73629620293273e-08	1.00769101538442	0.0365346998387176	MirTarget	-0.12281842246645	2.34384671714204e-10		NA	NA	NA
hsa-miR-18a-5p	FBP1	-2.29585803678176	4.139318990016e-14	2.60007311712345	3.66468362738826e-06	MirTarget	-0.497445174576123	3.83311300421063e-49		NA	NA	NA
hsa-miR-18a-5p	FEM1C	-2.29585803678176	4.139318990016e-14	0.617439719156988	0.209541192993276	miRNAWalker2_validate	-0.173013762406906	5.3483165847e-34		NA	NA	NA
hsa-miR-18a-5p	FGF1	-2.29585803678176	4.139318990016e-14	0.646653213999115	0.101194218943267	MirTarget	-0.308725947141596	9.70167258927243e-25		NA	NA	NA
hsa-miR-18a-5p	FNDC3A	-2.29585803678176	4.139318990016e-14	0.246631153777664	0.657117147928562	miRNATAP	-0.147319318642176	4.56307201490207e-21		NA	NA	NA
hsa-miR-18a-5p	FRS2	-2.29585803678176	4.139318990016e-14	1.13069960626707	0.0307676376940595	MirTarget	-0.257900743959529	2.45547348306966e-34		NA	NA	NA
hsa-miR-18a-5p	FRYL	-2.29585803678176	4.139318990016e-14	0.451537144620408	0.402771813048913	miRNATAP	-0.14842902721644	1.40370457600511e-20		NA	NA	NA
hsa-miR-18a-5p	GAB1	-2.29585803678176	4.139318990016e-14	0.508952389031208	0.286258106886842	MirTarget;miRNATAP	-0.178021538614324	3.83791153370437e-26		NA	NA	NA
hsa-miR-452-5p	GARNL3	-2.0200941872388	0.000263136484394317	0.718799965048007	0.0160163051295992	MirTarget	-0.107368358553745	1.38035080469192e-08		NA	NA	NA
hsa-miR-18a-5p	GAS7	-2.29585803678176	4.139318990016e-14	0.450207653056991	0.393461285145046	mirMAP	-0.257144385360811	3.25646718719617e-23		NA	NA	NA
hsa-miR-452-5p	GFRA1	-2.0200941872388	0.000263136484394317	4.85069320193537	6.52030013074452e-12	MirTarget	-0.599828090586184	6.96296920386979e-25		NA	NA	NA
hsa-miR-452-5p	GIN1	-2.0200941872388	0.000263136484394317	0.761297679337316	0.00308521919138974	MirTarget	-0.118894938831521	1.55621342881188e-34		NA	NA	NA
hsa-miR-452-5p	GLCCI1	-2.0200941872388	0.000263136484394317	1.0181212564435	0.0124653473541757	miRNATAP	-0.102483641213085	7.39710494738802e-10		NA	NA	NA
hsa-miR-18a-5p	GLRB	-2.29585803678176	4.139318990016e-14	1.38207703608463	4.47914851334139e-05	MirTarget;miRNATAP	-0.420712583557575	2.92416921018491e-29		NA	NA	NA
hsa-miR-18a-5p	GNA11	-2.29585803678176	4.139318990016e-14	0.187328717972723	0.667674171638137	MirTarget	-0.131470047953861	4.21510730519923e-13		NA	NA	NA
hsa-miR-18a-5p	GNG7	-2.29585803678176	4.139318990016e-14	-0.317962955990683	0.398489534323844	mirMAP	-0.102334215711126	0.000163584996294418		NA	NA	NA
hsa-miR-18a-5p	GNPDA2	-2.29585803678176	4.139318990016e-14	0.441401700771515	0.247543071258649	MirTarget	-0.137411618557432	2.11305820150809e-19		NA	NA	NA
hsa-miR-18a-5p	GTF2A1	-2.29585803678176	4.139318990016e-14	0.309679596591036	0.277386744834287	MirTarget	-0.208023597477171	5.11466996053174e-11		NA	NA	NA
hsa-miR-452-5p	GUF1	-2.0200941872388	0.000263136484394317	0.43538870471003	0.354730144624181	MirTarget	-0.102538809335099	1.38180797462674e-20		NA	NA	NA
hsa-miR-18a-5p	H6PD	-2.29585803678176	4.139318990016e-14	0.035510923019455	0.955452895307495	mirMAP	-0.126944181339438	8.99389486725863e-20		NA	NA	NA
hsa-miR-18a-5p	HERC1	-2.29585803678176	4.139318990016e-14	0.305543473174821	0.599547039669647	miRNAWalker2_validate	-0.166678978204255	1.41603516627385e-25		NA	NA	NA
hsa-miR-18a-5p	HIPK2	-2.29585803678176	4.139318990016e-14	0.0377895294478368	0.9505737594259	mirMAP	-0.116154083309191	4.06313103703854e-06		NA	NA	NA
hsa-miR-18a-5p	HLF	-2.29585803678176	4.139318990016e-14	-0.192061018115972	0.614775006708452	MirTarget	-0.226586768681528	6.54880708946071e-07		NA	NA	NA
hsa-miR-18a-5p	HMBOX1	-2.29585803678176	4.139318990016e-14	0.24439436470562	0.305843992773067	MirTarget;miRNATAP	-0.21100115910716	2.13179784211135e-22		NA	NA	NA
hsa-miR-224-5p	HOOK1	-2.65799597897592	2.73629620293273e-08	0.320441232782694	0.494519350705324	MirTarget	-0.137636419787246	1.08896338643111e-13		NA	NA	NA
hsa-miR-18a-5p	HOXA9	-2.29585803678176	4.139318990016e-14	-0.298313721458941	0.24004537666198	miRNAWalker2_validate	-0.190067368057164	5.3489040580045e-07		NA	NA	NA
hsa-miR-224-5p	HS6ST3	-2.65799597897592	2.73629620293273e-08	3.19061435708173	6.63410358317921e-16	MirTarget	-0.331132200847354	2.79506841971763e-13		NA	NA	NA
hsa-miR-224-5p	IGF1R	-2.65799597897592	2.73629620293273e-08	1.77526187705192	0.00817025787441957	mirMAP	-0.262380884793216	2.0900858366331e-34		NA	NA	NA
hsa-miR-452-5p	IGF1R	-2.0200941872388	0.000263136484394317	1.77526187705192	0.00817025787441957	mirMAP	-0.344176900884078	2.14757949011712e-41		NA	NA	NA
hsa-miR-18a-5p	IGFBP5	-2.29585803678176	4.139318990016e-14	1.22351036476979	0.164375209536685	mirMAP	-0.225414876847806	1.60030082423832e-09		NA	NA	NA
hsa-miR-18a-5p	IL17B	-2.29585803678176	4.139318990016e-14	-0.0451527200104116	0.894455044253154	MirTarget	-0.280256674044975	5.69689446160658e-07		NA	NA	NA
hsa-miR-452-5p	IL6ST	-2.0200941872388	0.000263136484394317	2.17150435425912	0.000169593545858536	mirMAP	-0.219664066998091	1.43869954863149e-07		NA	NA	NA
hsa-miR-452-5p	INPP4B	-2.0200941872388	0.000263136484394317	2.68378356215407	1.84906706606537e-10	mirMAP	-0.285594648215494	5.57157212691772e-23		NA	NA	NA
hsa-miR-18a-5p	ITGA2	-2.29585803678176	4.139318990016e-14	0.675598414227916	0.174926410785877	MirTarget	-0.277288585922338	1.4587093955565e-19		NA	NA	NA
hsa-miR-224-5p	ITPR1	-2.65799597897592	2.73629620293273e-08	1.63368853616216	0.00386290054134818	MirTarget	-0.112218610852405	4.23785403321903e-08		NA	NA	NA
hsa-miR-18a-5p	KCNA1	-2.29585803678176	4.139318990016e-14	0.285937679368812	0.400718947761982	MirTarget;miRNATAP	-0.365812218557213	2.64695980468239e-12		NA	NA	NA
hsa-miR-224-5p	KCNC1	-2.65799597897592	2.73629620293273e-08	1.79171020395625	4.40638717645908e-07	mirMAP	-0.256759383791525	1.01199623062787e-12		NA	NA	NA
hsa-miR-224-5p	KCNE4	-2.65799597897592	2.73629620293273e-08	2.6152814086228	9.02454775558177e-08	mirMAP	-0.302286449119529	8.53597694360533e-22		NA	NA	NA
hsa-miR-224-5p	KCNH1	-2.65799597897592	2.73629620293273e-08	3.12169397110623	1.56314813864154e-25	MirTarget	-0.375868106199318	7.1188709842689e-28		NA	NA	NA
hsa-miR-224-5p	KIAA0040	-2.65799597897592	2.73629620293273e-08	1.40549204191684	0.0253529411700862	mirMAP	-0.159997278581442	6.80018791260307e-26		NA	NA	NA
hsa-miR-452-5p	KIAA1324L	-2.0200941872388	0.000263136484394317	1.43057421562687	0.000207162579226791	MirTarget	-0.112506372494853	1.02906108747922e-05		NA	NA	NA
hsa-miR-452-5p	KIAA1958	-2.0200941872388	0.000263136484394317	0.417375738158972	0.0223455426289282	mirMAP	-0.113860381258086	3.29878270308853e-07		NA	NA	NA
hsa-miR-18a-5p	KIF13B	-2.29585803678176	4.139318990016e-14	1.25873176082656	0.0332004869602111	mirMAP	-0.42694013307171	4.05713490942489e-69		NA	NA	NA
hsa-miR-224-5p	KIF26B	-2.65799597897592	2.73629620293273e-08	0.0277629404945481	0.93575668407206	mirMAP	-0.139706419316572	3.24956705344724e-08		NA	NA	NA
hsa-miR-452-5p	KIF26B	-2.0200941872388	0.000263136484394317	0.0277629404945481	0.93575668407206	mirMAP	-0.221237239580107	2.22458134943907e-13		NA	NA	NA
hsa-miR-452-5p	KIF6	-2.0200941872388	0.000263136484394317	0.385756410888955	0.0641933956072026	mirMAP	-0.128899948418844	2.67529669880625e-06		NA	NA	NA
hsa-miR-224-5p	KLHDC7A	-2.65799597897592	2.73629620293273e-08	4.34878627296191	9.42670341462595e-21	mirMAP	-0.397808497383201	8.83498153367304e-16		NA	NA	NA
hsa-miR-452-5p	KSR2	-2.0200941872388	0.000263136484394317	1.22962334316077	2.23333937111547e-07	mirMAP	-0.288941755288498	1.56339993504313e-21		NA	NA	NA
hsa-miR-452-5p	LARP4	-2.0200941872388	0.000263136484394317	0.506238780142107	0.344556804439047	mirMAP	-0.112354086300129	8.48373677911551e-25		NA	NA	NA
hsa-miR-452-5p	LCOR	-2.0200941872388	0.000263136484394317	0.876291030543331	0.000314441070410501	mirMAP	-0.14515036975589	7.67185558462574e-08		NA	NA	NA
hsa-miR-452-5p	LDLRAD3	-2.0200941872388	0.000263136484394317	0.48352456079848	0.323322660246481	MirTarget;miRNATAP	-0.174900562813006	2.77818955681254e-15		NA	NA	NA
hsa-miR-452-5p	LIN7A	-2.0200941872388	0.000263136484394317	2.45859632114862	2.74066706763851e-16	mirMAP	-0.111961366269578	0.00702279037426733		NA	NA	NA
hsa-miR-18a-5p	LONP2	-2.29585803678176	4.139318990016e-14	0.572293949051525	0.320540277276559	mirMAP	-0.13034580866847	6.3129851607025e-14		NA	NA	NA
hsa-miR-18a-5p	LONRF2	-2.29585803678176	4.139318990016e-14	3.45738858653069	1.11871959084766e-13	mirMAP	-0.656490113300794	9.01275306546033e-40		NA	NA	NA
hsa-miR-224-5p	LONRF2	-2.65799597897592	2.73629620293273e-08	3.45738858653069	1.11871959084766e-13	mirMAP	-0.416771985708289	2.44492523233115e-35		NA	NA	NA
hsa-miR-18a-5p	LPP	-2.29585803678176	4.139318990016e-14	-0.0599000979079998	0.881653412887322	mirMAP	-0.200432677688042	1.54370427595509e-14		NA	NA	NA
hsa-miR-18a-5p	LRP10	-2.29585803678176	4.139318990016e-14	0.636168125677098	0.378249726866834	mirMAP	-0.193626966923308	2.71454814841761e-55		NA	NA	NA
hsa-miR-224-5p	LRRC15	-2.65799597897592	2.73629620293273e-08	0.95105145810685	0.0919749144748638	mirMAP	-0.169795004694771	2.01025878841557e-07		NA	NA	NA
hsa-miR-224-5p	LRRC27	-2.65799597897592	2.73629620293273e-08	0.735246017581391	0.0356653720974567	mirMAP	-0.117973589619973	5.714335906615e-30		NA	NA	NA
hsa-miR-452-5p	LYPD6	-2.0200941872388	0.000263136484394317	2.21413531746783	1.42051968104332e-08	MirTarget	-0.348098315464678	9.21763428330733e-19		NA	NA	NA
hsa-miR-18a-5p	MAN2B2	-2.29585803678176	4.139318990016e-14	0.807991584039158	0.166308029102152	mirMAP	-0.203760849703937	1.573557107246e-51		NA	NA	NA
hsa-miR-18a-5p	MAP3K1	-2.29585803678176	4.139318990016e-14	1.01322313132264	0.0792800255031362	miRNATAP	-0.316610440339497	2.14317799336319e-46		NA	NA	NA
hsa-miR-452-5p	MAP9	-2.0200941872388	0.000263136484394317	0.945841447659317	0.0186685740418283	mirMAP	-0.115738215418284	7.68844395070897e-07		NA	NA	NA
hsa-miR-452-5p	MBOAT2	-2.0200941872388	0.000263136484394317	-0.0445641842455133	0.923176435422446	MirTarget	-0.10783559337144	5.09054216500219e-08		NA	NA	NA
hsa-miR-18a-5p	MDGA1	-2.29585803678176	4.139318990016e-14	0.831308540027256	0.0041539322111643	miRNATAP	-0.200479649226778	5.41840066449566e-14		NA	NA	NA
hsa-miR-18a-5p	MEF2C	-2.29585803678176	4.139318990016e-14	-0.0448929221885495	0.922394998525297	MirTarget	-0.127566112747227	1.28918194375564e-10		NA	NA	NA
hsa-miR-18a-5p	MEF2D	-2.29585803678176	4.139318990016e-14	0.479136295251634	0.43305070973643	miRNATAP	-0.13204707652659	2.29150705324917e-30		NA	NA	NA
hsa-miR-452-5p	MGAT4A	-2.0200941872388	0.000263136484394317	0.868907005606655	0.125559704091774	mirMAP	-0.18202418558363	1.26197952585819e-22		NA	NA	NA
hsa-miR-452-5p	MIER3	-2.0200941872388	0.000263136484394317	0.73103461542595	0.095299953576901	mirMAP	-0.101600596666067	1.08490381436567e-16		NA	NA	NA
hsa-miR-452-5p	MIPOL1	-2.0200941872388	0.000263136484394317	0.889270574490043	0.000883731560805362	mirMAP	-0.206221989309795	1.40431576801944e-31		NA	NA	NA
hsa-miR-452-5p	MLLT3	-2.0200941872388	0.000263136484394317	0.76318925454779	0.0478738419386683	mirMAP	-0.104494797816157	3.04444681789214e-08		NA	NA	NA
hsa-miR-452-5p	MORN4	-2.0200941872388	0.000263136484394317	0.808844285722047	0.00719909247607369	MirTarget	-0.152926482067414	6.94626846438024e-32		NA	NA	NA
hsa-miR-18a-5p	MPPED2	-2.29585803678176	4.139318990016e-14	0.687187817124928	0.00900743840652314	mirMAP	-0.210280450250362	7.08623181228274e-08		NA	NA	NA
hsa-miR-452-5p	MRPS23	-2.0200941872388	0.000263136484394317	0.192007971050279	0.692244429510367	MirTarget	-0.103001810578998	2.2958680320753e-15		NA	NA	NA
hsa-miR-224-5p	MSI2	-2.65799597897592	2.73629620293273e-08	1.09548878689487	0.00371116176785885	mirMAP	-0.163080644048041	1.73072951171833e-27		NA	NA	NA
hsa-miR-18a-5p	MTHFR	-2.29585803678176	4.139318990016e-14	0.497025274176286	0.299164152456537	mirMAP	-0.1679667982994	4.02543773165036e-24		NA	NA	NA
hsa-miR-452-5p	MZF1	-2.0200941872388	0.000263136484394317	0.866892768448895	0.0315854877958465	MirTarget	-0.155934029830045	1.07577058643123e-20		NA	NA	NA
hsa-miR-18a-5p	NBEA	-2.29585803678176	4.139318990016e-14	1.96176842607598	1.57470607601836e-07	miRNAWalker2_validate	-0.528982821660413	7.82609567879678e-60		NA	NA	NA
hsa-miR-452-5p	NCAM2	-2.0200941872388	0.000263136484394317	3.27738197515256	1.98213311238211e-21	mirMAP	-0.356299124015064	3.73144417802513e-19		NA	NA	NA
hsa-miR-18a-5p	NCOA1	-2.29585803678176	4.139318990016e-14	0.108333665090036	0.848773517382567	MirTarget;miRNATAP	-0.134970373152042	9.83382622027132e-23		NA	NA	NA
hsa-miR-452-5p	NEBL	-2.0200941872388	0.000263136484394317	1.05831926294288	0.0841559975363851	mirMAP	-0.201271800427687	6.69238383669138e-23		NA	NA	NA
hsa-miR-18a-5p	NEDD4	-2.29585803678176	4.139318990016e-14	0.5661557972851	0.164921384788646	MirTarget;miRNATAP	-0.237772989643153	1.33736803467272e-37		NA	NA	NA
hsa-miR-18a-5p	NEDD9	-2.29585803678176	4.139318990016e-14	0.0175351186790076	0.975252924001639	miRTarBase;MirTarget;miRNATAP	-0.200054503528031	5.0385866880316e-15	22308110	NEDD9 and CDK19 were identified as novel miR-18a targets and were shown to be pro-proliferative genes with RNA interference of their transcripts decreasing proliferation in CRC cells		colorectal cancer
hsa-miR-18a-5p	NHLRC2	-2.29585803678176	4.139318990016e-14	0.312601885176039	0.236452791785796	mirMAP	-0.160538006387603	2.85525253960548e-12		NA	NA	NA
hsa-miR-224-5p	NOS1AP	-2.65799597897592	2.73629620293273e-08	0.942412633158364	0.00121312263549907	mirMAP	-0.172748198450688	4.61841813863436e-11		NA	NA	NA
hsa-miR-452-5p	NOSTRIN	-2.0200941872388	0.000263136484394317	2.59510417514666	4.12335730393627e-09	miRNATAP	-0.173686899148375	1.96996161118543e-08		NA	NA	NA
hsa-miR-452-5p	NPEPPS	-2.0200941872388	0.000263136484394317	0.556577189255887	0.368857249561216	MirTarget;miRNATAP	-0.114171843834003	5.55421940163219e-21		NA	NA	NA
hsa-miR-452-5p	NPHP1	-2.0200941872388	0.000263136484394317	1.0839763305285	2.52604210566751e-05	MirTarget	-0.145175127955314	3.72260622588147e-21		NA	NA	NA
hsa-miR-18a-5p	NR3C1	-2.29585803678176	4.139318990016e-14	0.0422673261543753	0.939324296532065	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.16520939885116	1.39190676142027e-13		NA	NA	NA
hsa-miR-452-5p	NRCAM	-2.0200941872388	0.000263136484394317	0.751367039343555	0.0129588650968411	MirTarget	-0.151058712476026	4.6086562821616e-06		NA	NA	NA
hsa-miR-18a-5p	NRG1	-2.29585803678176	4.139318990016e-14	-0.350226527230034	0.259630594465776	miRNATAP	-0.243721864987581	3.32805830007628e-06		NA	NA	NA
hsa-miR-18a-5p	NTRK3	-2.29585803678176	4.139318990016e-14	-0.647062771111165	0.0605869384885259	mirMAP	-0.221782427020024	6.64375802513301e-05		NA	NA	NA
hsa-miR-224-5p	OCLN	-2.65799597897592	2.73629620293273e-08	0.530790565363215	0.15446883854466	MirTarget	-0.107443429617349	7.26122201955664e-09		NA	NA	NA
hsa-miR-18a-5p	OLFML2A	-2.29585803678176	4.139318990016e-14	0.69627018751495	0.184675319316508	mirMAP	-0.195371289535398	5.30593895273794e-22		NA	NA	NA
hsa-miR-18a-5p	ORAI3	-2.29585803678176	4.139318990016e-14	0.924063958047161	0.0459152532310564	miRNAWalker2_validate;miRNATAP	-0.17646569687491	1.83610431856552e-27		NA	NA	NA
hsa-miR-452-5p	PANK3	-2.0200941872388	0.000263136484394317	0.876691753369824	0.0648233466046793	mirMAP	-0.143084526532804	3.95075988895581e-18		NA	NA	NA
hsa-miR-18a-5p	PAPPA	-2.29585803678176	4.139318990016e-14	-0.00105330256293934	0.996408656929167	miRNATAP	-0.131810384950291	1.17242589142028e-05		NA	NA	NA
hsa-miR-18a-5p	PARD6B	-2.29585803678176	4.139318990016e-14	1.86380518224737	1.73020124710611e-05	miRNAWalker2_validate;MirTarget	-0.284811022335125	1.39901909644042e-14		NA	NA	NA
hsa-miR-452-5p	PAX9	-2.0200941872388	0.000263136484394317	2.24734881804845	9.61750952378205e-13	mirMAP	-0.252211785432396	5.48995649421011e-12		NA	NA	NA
hsa-miR-18a-5p	PCBD2	-2.29585803678176	4.139318990016e-14	0.841375605337066	0.0314846497560825	mirMAP	-0.147378285611701	7.88716172628899e-25		NA	NA	NA
hsa-miR-224-5p	PCBD2	-2.65799597897592	2.73629620293273e-08	0.841375605337066	0.0314846497560825	mirMAP	-0.11763017896128	2.61421070172109e-35		NA	NA	NA
hsa-miR-224-5p	PCDH10	-2.65799597897592	2.73629620293273e-08	1.51175429036909	0.000184690500360874	MirTarget	-0.143049698734046	0.000957362294977745		NA	NA	NA
hsa-miR-18a-5p	PCDHGA10	-2.29585803678176	4.139318990016e-14	1.02599338770521	0.000229629541107103	mirMAP	-0.242139355042132	1.00366706189103e-08		NA	NA	NA
hsa-miR-18a-5p	PCDHGA12	-2.29585803678176	4.139318990016e-14	0.61479128788859	0.00801632766631188	mirMAP	-0.232968463381782	7.18619587742436e-11		NA	NA	NA
hsa-miR-18a-5p	PCDHGA2	-2.29585803678176	4.139318990016e-14	0.366883725657329	0.163611348779999	mirMAP	-0.393699736732539	2.07049087605291e-20		NA	NA	NA
hsa-miR-18a-5p	PCDHGA3	-2.29585803678176	4.139318990016e-14	0.375384995335331	0.0860587312531216	mirMAP	-0.310939315331092	5.85295983356843e-18		NA	NA	NA
hsa-miR-18a-5p	PCDHGA4	-2.29585803678176	4.139318990016e-14	0.491944025223461	0.0446640271103477	mirMAP	-0.270711505047657	2.8894474513565e-11		NA	NA	NA
hsa-miR-18a-5p	PCDHGA5	-2.29585803678176	4.139318990016e-14	0.504232992352929	0.0356690469940882	mirMAP	-0.331952352035761	7.19409680481861e-17		NA	NA	NA
hsa-miR-18a-5p	PCDHGA6	-2.29585803678176	4.139318990016e-14	0.306181887310044	0.131637428477699	mirMAP	-0.2355442960291	1.71995216927291e-12		NA	NA	NA
hsa-miR-18a-5p	PCDHGA7	-2.29585803678176	4.139318990016e-14	0.510368658074136	0.0254377527770088	mirMAP	-0.246415074762893	1.09196217715879e-10		NA	NA	NA
hsa-miR-18a-5p	PCDHGA9	-2.29585803678176	4.139318990016e-14	0.929058857476342	7.3287059629956e-05	mirMAP	-0.371763758709927	4.79180816588326e-23		NA	NA	NA
hsa-miR-18a-5p	PCDHGB2	-2.29585803678176	4.139318990016e-14	-0.0162486274221856	0.947633795296215	mirMAP	-0.189902126044122	3.49203348705015e-06		NA	NA	NA
hsa-miR-18a-5p	PCDHGB3	-2.29585803678176	4.139318990016e-14	-0.460816760938844	0.0691447041864259	mirMAP	-0.131766555226161	0.000652098635404244		NA	NA	NA
hsa-miR-18a-5p	PCDHGB4	-2.29585803678176	4.139318990016e-14	0.258895150993977	0.340712444958824	mirMAP	-0.211671953766436	3.24984970679208e-06		NA	NA	NA
hsa-miR-18a-5p	PCDHGB6	-2.29585803678176	4.139318990016e-14	0.608780972134696	0.00833025630621594	mirMAP	-0.314370946614473	1.55748090909347e-19		NA	NA	NA
hsa-miR-18a-5p	PCDHGB7	-2.29585803678176	4.139318990016e-14	0.93034539306053	0.00210967095174942	mirMAP	-0.418220524698778	3.98944932120566e-29		NA	NA	NA
hsa-miR-18a-5p	PCDHGC5	-2.29585803678176	4.139318990016e-14	-0.237423039813539	0.396043617746842	mirMAP	-0.110642905783501	0.00411137141632271		NA	NA	NA
hsa-miR-18a-5p	PDE4A	-2.29585803678176	4.139318990016e-14	0.74503960479981	0.0849222677024279	mirMAP	-0.219492173758275	5.10863328798831e-20		NA	NA	NA
hsa-miR-18a-5p	PDE5A	-2.29585803678176	4.139318990016e-14	0.615016630060294	0.154056136101873	MirTarget	-0.242971636442388	1.60889514256819e-14		NA	NA	NA
hsa-miR-452-5p	PDIK1L	-2.0200941872388	0.000263136484394317	0.506920078339496	0.210948355820368	MirTarget;mirMAP	-0.138107454590912	4.80951516427244e-35		NA	NA	NA
hsa-miR-224-5p	PGPEP1	-2.65799597897592	2.73629620293273e-08	1.05692097283076	0.0296824993140339	mirMAP	-0.122718217018104	9.31681101944436e-25		NA	NA	NA
hsa-miR-452-5p	PGR	-2.0200941872388	0.000263136484394317	4.97051494401714	4.92890957537736e-17	mirMAP	-0.57638681638652	2.82946527475521e-23		NA	NA	NA
hsa-miR-18a-5p	PHC3	-2.29585803678176	4.139318990016e-14	0.309485945461203	0.574880189509787	MirTarget	-0.139881081162043	2.42586368229585e-23		NA	NA	NA
hsa-miR-224-5p	PPP2R2C	-2.65799597897592	2.73629620293273e-08	1.30001069513157	0.00338224559384741	mirMAP	-0.103300631656607	0.0327111600518789		NA	NA	NA
hsa-miR-18a-5p	PRDM2	-2.29585803678176	4.139318990016e-14	0.228035601894346	0.674831075008548	mirMAP	-0.135945572227408	1.74400245048004e-28		NA	NA	NA
hsa-miR-18a-5p	PRICKLE2	-2.29585803678176	4.139318990016e-14	1.20320410751354	0.0117589308024568	MirTarget	-0.387730469036141	3.85619154280423e-61		NA	NA	NA
hsa-miR-18a-5p	PRKACB	-2.29585803678176	4.139318990016e-14	0.25863238617857	0.620572444315029	miRNATAP	-0.109828861303179	0.000270889162356874		NA	NA	NA
hsa-miR-452-5p	PRSS23	-2.0200941872388	0.000263136484394317	1.36834067783092	0.046318758728592	MirTarget	-0.200348610730139	6.39140826848555e-19		NA	NA	NA
hsa-miR-18a-5p	PSD3	-2.29585803678176	4.139318990016e-14	1.07814986077885	0.0323687013905805	MirTarget;miRNATAP	-0.328605773072599	1.77038091254639e-18		NA	NA	NA
hsa-miR-452-5p	PSD3	-2.0200941872388	0.000263136484394317	1.07814986077885	0.0323687013905805	mirMAP	-0.16276531115563	1.10809695129555e-07		NA	NA	NA
hsa-miR-18a-5p	PTEN	-2.29585803678176	4.139318990016e-14	0.679266578822795	0.257263534525925	miRNAWalker2_validate;miRTarBase	-0.135863155421297	1.28041670903141e-19	24681249;27291152	However higher levels of the miR-17~92 cluster switched from PTEN to oncogenes including Ctnnb1 β-catenin via miR-18a which resulted in inhibition of tumor growth and metastasis;miR 18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN PI3K AKT mTOR signaling axis	metastasis;	colon cancer;esophageal cancer
hsa-miR-18a-5p	PTGR2	-2.29585803678176	4.139318990016e-14	0.777783849276349	0.0456839338083313	mirMAP	-0.184357353835607	2.38040349373915e-28		NA	NA	NA
hsa-miR-452-5p	QSOX1	-2.0200941872388	0.000263136484394317	0.148920814941786	0.833149928405061	mirMAP	-0.118738757983793	9.2685056037116e-12		NA	NA	NA
hsa-miR-18a-5p	RAB11FIP2	-2.29585803678176	4.139318990016e-14	0.195186300969823	0.62504337863968	miRNATAP	-0.131419776760754	1.41019834295424e-20		NA	NA	NA
hsa-miR-452-5p	RAB11FIP4	-2.0200941872388	0.000263136484394317	0.567978721296488	0.258779849485191	MirTarget	-0.193153361643073	1.06729906017479e-25		NA	NA	NA
hsa-miR-452-5p	RAB30	-2.0200941872388	0.000263136484394317	1.70569527781604	1.18658635861988e-07	mirMAP	-0.225271947700095	5.16968131120998e-18		NA	NA	NA
hsa-miR-452-5p	RAB39B	-2.0200941872388	0.000263136484394317	0.430719819788716	0.0799601073694602	mirMAP	-0.132777173011367	4.83492311380014e-05		NA	NA	NA
hsa-miR-452-5p	RAB3B	-2.0200941872388	0.000263136484394317	0.251621991216551	0.482556519877873	mirMAP	-0.10775387847213	0.00700124394183601		NA	NA	NA
hsa-miR-452-5p	RABEP1	-2.0200941872388	0.000263136484394317	1.49551708525558	0.0227719483086121	mirMAP	-0.213332233678406	2.03174534441853e-40		NA	NA	NA
hsa-miR-452-5p	RAD50	-2.0200941872388	0.000263136484394317	0.713192167893928	0.197836402459169	MirTarget	-0.113016272564666	1.04401408908458e-19		NA	NA	NA
hsa-miR-452-5p	RAI1	-2.0200941872388	0.000263136484394317	0.306885166344835	0.564693899646153	MirTarget;miRNATAP	-0.100425840321699	2.03747700357122e-16		NA	NA	NA
hsa-miR-452-5p	RALGAPB	-2.0200941872388	0.000263136484394317	0.488690322104464	0.422496690232663	mirMAP	-0.105247687804124	3.60765029941074e-21		NA	NA	NA
hsa-miR-224-5p	RALGPS1	-2.65799597897592	2.73629620293273e-08	0.960221841408952	0.00959003739183846	MirTarget	-0.153608281754376	6.53878909680175e-37		NA	NA	NA
hsa-miR-224-5p	RASEF	-2.65799597897592	2.73629620293273e-08	1.87655405791426	6.43122846955932e-07	MirTarget	-0.260730969089573	7.17620023934144e-16		NA	NA	NA
hsa-miR-18a-5p	RASSF3	-2.29585803678176	4.139318990016e-14	-0.0816427024517798	0.807814524136364	miRNAWalker2_validate	-0.119286529464504	5.34516181306598e-05		NA	NA	NA
hsa-miR-18a-5p	REPS2	-2.29585803678176	4.139318990016e-14	1.7086889265294	0.000515429803981469	miRNATAP	-0.336091234448453	3.36601961780141e-25		NA	NA	NA
hsa-miR-224-5p	RHBDL3	-2.65799597897592	2.73629620293273e-08	1.68879349774576	5.94975874500791e-11	mirMAP	-0.122096438660271	3.56923152669604e-05		NA	NA	NA
hsa-miR-18a-5p	RIC3	-2.29585803678176	4.139318990016e-14	-0.20476328368041	0.526669153736984	MirTarget	-0.173325578344466	0.00105174522994952		NA	NA	NA
hsa-miR-18a-5p	RICTOR	-2.29585803678176	4.139318990016e-14	0.38363074704787	0.426040024248714	miRNAWalker2_validate	-0.115801044552433	7.86023931866078e-13		NA	NA	NA
hsa-miR-18a-5p	RIMS4	-2.29585803678176	4.139318990016e-14	3.89846167236698	2.86202829464093e-19	mirMAP	-0.416951868244038	5.72613913864664e-11		NA	NA	NA
hsa-miR-18a-5p	RNF157	-2.29585803678176	4.139318990016e-14	0.983348924038851	0.00168399891767057	miRNAWalker2_validate	-0.243397382730955	4.64692012386867e-12		NA	NA	NA
hsa-miR-18a-5p	ROBO2	-2.29585803678176	4.139318990016e-14	3.25296458550521	1.008966767749e-16	miRNATAP	-0.507935667314834	4.30543821372391e-14		NA	NA	NA
hsa-miR-18a-5p	RORA	-2.29585803678176	4.139318990016e-14	0.123520018727089	0.749873453545262	MirTarget;miRNATAP	-0.159888453401577	1.01092266626298e-16		NA	NA	NA
hsa-miR-18a-5p	RPS6KA5	-2.29585803678176	4.139318990016e-14	0.819186707092899	0.0108289170870186	MirTarget	-0.304839062313663	1.17673769849974e-37		NA	NA	NA
hsa-miR-18a-5p	RUNX1	-2.29585803678176	4.139318990016e-14	0.430966241210268	0.529704329917927	miRNATAP	-0.159910187601787	2.2967282372377e-20		NA	NA	NA
hsa-miR-452-5p	SBK1	-2.0200941872388	0.000263136484394317	0.0493881938699499	0.912159854791582	mirMAP	-0.257312863885347	1.87628706310842e-26		NA	NA	NA
hsa-miR-18a-5p	SDC4	-2.29585803678176	4.139318990016e-14	0.285803974421723	0.701837635110456	MirTarget	-0.13009744301677	2.38243911448905e-12		NA	NA	NA
hsa-miR-224-5p	SDC4	-2.65799597897592	2.73629620293273e-08	0.285803974421723	0.701837635110456	MirTarget	-0.100112838718792	6.96775647086021e-16		NA	NA	NA
hsa-miR-224-5p	SEC16A	-2.65799597897592	2.73629620293273e-08	0.864083072476553	0.223066589599513	MirTarget	-0.118941357270567	7.19055076379025e-33		NA	NA	NA
hsa-miR-18a-5p	SERTAD3	-2.29585803678176	4.139318990016e-14	0.659287453942886	0.195193788811258	miRNAWalker2_validate	-0.105493496016499	4.6995939584212e-12		NA	NA	NA
hsa-miR-18a-5p	SH3BP4	-2.29585803678176	4.139318990016e-14	0.908151212052202	0.148172820612864	miRNATAP	-0.257507232453363	1.27695549003647e-39		NA	NA	NA
hsa-miR-18a-5p	SH3RF1	-2.29585803678176	4.139318990016e-14	0.5483283174813	0.27786765681897	miRNATAP	-0.151588008583245	1.53940609351226e-17		NA	NA	NA
hsa-miR-224-5p	SHANK2	-2.65799597897592	2.73629620293273e-08	0.260056029890085	0.597458473228173	mirMAP	-0.107562648607512	6.2253289306017e-09		NA	NA	NA
hsa-miR-452-5p	SHANK2	-2.0200941872388	0.000263136484394317	0.260056029890085	0.597458473228173	mirMAP	-0.15121502961319	8.86101838000207e-12		NA	NA	NA
hsa-miR-224-5p	SHISA9	-2.65799597897592	2.73629620293273e-08	2.22621195772902	1.00297389872666e-08	MirTarget	-0.156485774336624	0.000347300328186189		NA	NA	NA
hsa-miR-452-5p	SHISA9	-2.0200941872388	0.000263136484394317	2.22621195772902	1.00297389872666e-08	mirMAP	-0.174415216371001	0.000911859347080672		NA	NA	NA
hsa-miR-224-5p	SLC1A2	-2.65799597897592	2.73629620293273e-08	1.60022216918241	5.72253015131517e-06	mirMAP	-0.25440787900545	8.99142905055228e-18		NA	NA	NA
hsa-miR-452-5p	SLC22A15	-2.0200941872388	0.000263136484394317	0.570705332093822	0.015836311203764	MirTarget	-0.171865485367672	1.14639917801994e-17		NA	NA	NA
hsa-miR-18a-5p	SLC27A1	-2.29585803678176	4.139318990016e-14	0.531836694440708	0.307003508220529	mirMAP	-0.170803449949827	5.12930789705189e-24		NA	NA	NA
hsa-miR-18a-5p	SLC35E2B	-2.29585803678176	4.139318990016e-14	0.593753169013584	0.351595415426376	mirMAP	-0.126416933557067	6.84911566025307e-18		NA	NA	NA
hsa-miR-452-5p	SLC44A1	-2.0200941872388	0.000263136484394317	0.320418185749795	0.623348317781433	mirMAP	-0.111348040705478	8.46407895569039e-23		NA	NA	NA
hsa-miR-224-5p	SLC4A10	-2.65799597897592	2.73629620293273e-08	1.28259236008284	0.00383913254061725	MirTarget	-0.141934732191965	0.00034677614157337		NA	NA	NA
hsa-miR-18a-5p	SMAD3	-2.29585803678176	4.139318990016e-14	0.634620777185636	0.245352362300656	miRNAWalker2_validate	-0.145191271950291	4.28063578565896e-20	23249750	The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling		glioblastoma
hsa-miR-18a-5p	SNED1	-2.29585803678176	4.139318990016e-14	1.1948779970144	0.0096218384721799	mirMAP	-0.319040754684096	5.13107237957617e-46		NA	NA	NA
hsa-miR-18a-5p	SNURF	-2.29585803678176	4.139318990016e-14	1.28249234268988	4.3317666709386e-06	MirTarget	-0.35021993981869	1.67687544409287e-15		NA	NA	NA
hsa-miR-18a-5p	SNX33	-2.29585803678176	4.139318990016e-14	0.306143719309897	0.545887576158479	mirMAP	-0.111579364347877	2.34163849455721e-25		NA	NA	NA
hsa-miR-18a-5p	SORBS2	-2.29585803678176	4.139318990016e-14	-0.685421986210025	0.197688125344387	MirTarget;miRNATAP	-0.120505517582452	0.000739455687797636		NA	NA	NA
hsa-miR-224-5p	SPOPL	-2.65799597897592	2.73629620293273e-08	1.04189658932989	0.0517644400631705	MirTarget	-0.122502702086306	7.89758233400106e-22		NA	NA	NA
hsa-miR-452-5p	SPOPL	-2.0200941872388	0.000263136484394317	1.04189658932989	0.0517644400631705	mirMAP	-0.173385622119362	2.74524545779626e-30		NA	NA	NA
hsa-miR-452-5p	SRCIN1	-2.0200941872388	0.000263136484394317	1.87466559257072	4.0148133408198e-06	MirTarget	-0.246740769466645	1.72555021557871e-21		NA	NA	NA
hsa-miR-452-5p	SRP54	-2.0200941872388	0.000263136484394317	0.374899241712576	0.494002793523028	MirTarget;miRNATAP	-0.1046370750481	1.13419406235669e-26		NA	NA	NA
hsa-miR-18a-5p	SSTR1	-2.29585803678176	4.139318990016e-14	1.42180151727989	9.13650468007887e-07	mirMAP	-0.528324795520575	1.56756939407685e-30		NA	NA	NA
hsa-miR-18a-5p	ST6GAL2	-2.29585803678176	4.139318990016e-14	1.17110612856311	0.000157851090404832	mirMAP	-0.270495142030909	9.4894012713475e-13		NA	NA	NA
hsa-miR-452-5p	STC1	-2.0200941872388	0.000263136484394317	0.658741831646943	0.197943644911406	miRNATAP	-0.133915237267937	1.15039796540307e-05		NA	NA	NA
hsa-miR-18a-5p	STX1B	-2.29585803678176	4.139318990016e-14	0.70885443839874	0.000415318844266855	mirMAP	-0.232229169453795	9.28428200268792e-16		NA	NA	NA
hsa-miR-452-5p	SULF1	-2.0200941872388	0.000263136484394317	0.418126907195565	0.529805754339193	MirTarget	-0.108461489183832	1.21638148843222e-05		NA	NA	NA
hsa-miR-452-5p	SULF2	-2.0200941872388	0.000263136484394317	0.693567666924667	0.320993289317501	mirMAP	-0.101698984951153	5.41090333120449e-07		NA	NA	NA
hsa-miR-452-5p	SYT1	-2.0200941872388	0.000263136484394317	2.82001079104867	1.28047553625101e-11	mirMAP;miRNATAP	-0.418845673195687	4.16129562687673e-18		NA	NA	NA
hsa-miR-18a-5p	SYT15	-2.29585803678176	4.139318990016e-14	-0.412298480523126	0.110892603988313	MirTarget	-0.108266350583212	0.000935039095132359		NA	NA	NA
hsa-miR-18a-5p	SYT7	-2.29585803678176	4.139318990016e-14	0.60633587604153	0.294799348790943	mirMAP	-0.104422314630191	0.000315556188007855		NA	NA	NA
hsa-miR-18a-5p	TAOK1	-2.29585803678176	4.139318990016e-14	0.581019679787721	0.132484045479884	MirTarget;miRNATAP	-0.242306979841869	7.7801284064685e-11		NA	NA	NA
hsa-miR-452-5p	TAPT1	-2.0200941872388	0.000263136484394317	0.876404843769192	0.0686670773534909	MirTarget	-0.140556201580506	2.19856978923992e-27		NA	NA	NA
hsa-miR-18a-5p	TGFBR2	-2.29585803678176	4.139318990016e-14	0.246514824067336	0.705049761423498	miRNAWalker2_validate	-0.233316456798081	1.26332307500906e-18		NA	NA	NA
hsa-miR-18a-5p	TGFBR3	-2.29585803678176	4.139318990016e-14	0.250325459308409	0.65335981637459	MirTarget	-0.374834046066299	3.17870910707835e-19		NA	NA	NA
hsa-miR-18a-5p	THBS1	-2.29585803678176	4.139318990016e-14	0.497430447016999	0.534063430907669	MirTarget	-0.181152396860618	8.69562380186631e-14		NA	NA	NA
hsa-miR-18a-5p	THRA	-2.29585803678176	4.139318990016e-14	0.727752573193046	0.14565562737712	miRNAWalker2_validate	-0.15778559532931	1.4522589546335e-15		NA	NA	NA
hsa-miR-18a-5p	THRB	-2.29585803678176	4.139318990016e-14	1.20141153466674	0.00835555391894907	MirTarget	-0.382941858083479	3.6050052574153e-41		NA	NA	NA
hsa-miR-18a-5p	TLE3	-2.29585803678176	4.139318990016e-14	0.977701039165165	0.115292568887507	miRNAWalker2_validate	-0.175378552602682	7.02951783854717e-27		NA	NA	NA
hsa-miR-452-5p	TMED7	-2.0200941872388	0.000263136484394317	0.674496930120523	0.270665642467818	MirTarget	-0.113049523988338	1.3370815950115e-22		NA	NA	NA
hsa-miR-452-5p	TMEM229B	-2.0200941872388	0.000263136484394317	1.44669582776392	0.000302079996411229	MirTarget	-0.215291353803972	1.02842361156985e-25		NA	NA	NA
hsa-miR-452-5p	TMEM232	-2.0200941872388	0.000263136484394317	2.42126759270622	8.37783244298729e-21	MirTarget	-0.221650669813412	7.60839038461403e-11		NA	NA	NA
hsa-miR-18a-5p	TNS1	-2.29585803678176	4.139318990016e-14	0.42937300584437	0.549551979636777	mirMAP	-0.277210513830642	4.31505251632845e-24		NA	NA	NA
hsa-miR-18a-5p	TP73	-2.29585803678176	4.139318990016e-14	0.969314477633702	4.14781484323784e-05	mirMAP	-0.22065384786784	1.19104385169831e-09		NA	NA	NA
hsa-miR-18a-5p	TRAF5	-2.29585803678176	4.139318990016e-14	0.689593424758661	0.151568111238616	MirTarget	-0.128267488900121	9.95478770535342e-11		NA	NA	NA
hsa-miR-18a-5p	TRIM8	-2.29585803678176	4.139318990016e-14	0.590377783634488	0.353695939097395	MirTarget	-0.139326895343003	1.27470825650245e-30		NA	NA	NA
hsa-miR-18a-5p	TSC22D3	-2.29585803678176	4.139318990016e-14	1.37958369528341	0.0489153581437249	miRNAWalker2_validate	-0.271271829119523	9.73837470551859e-41		NA	NA	NA
hsa-miR-18a-5p	TSHZ3	-2.29585803678176	4.139318990016e-14	0.676781346106153	0.0612682832400892	MirTarget;miRNATAP	-0.215971774081914	6.12464974769798e-23		NA	NA	NA
hsa-miR-18a-5p	TTC28	-2.29585803678176	4.139318990016e-14	0.63422143702943	0.146403869409613	mirMAP	-0.290608470141428	6.51531949277842e-48		NA	NA	NA
hsa-miR-224-5p	TTC39A	-2.65799597897592	2.73629620293273e-08	1.89094597246798	0.00139409134554201	mirMAP	-0.276154991997567	5.82926518213187e-33		NA	NA	NA
hsa-miR-18a-5p	TTC8	-2.29585803678176	4.139318990016e-14	1.16936275744825	0.00767535489157048	MirTarget	-0.24444297545988	5.60419117331458e-55		NA	NA	NA
hsa-miR-18a-5p	TXNDC15	-2.29585803678176	4.139318990016e-14	0.403856914939907	0.459184902471529	miRNAWalker2_validate	-0.108922503750806	3.52469179828444e-31		NA	NA	NA
hsa-miR-452-5p	UBE3A	-2.0200941872388	0.000263136484394317	0.507296914169401	0.396327510704135	MirTarget	-0.103625192387646	9.34123415564561e-22		NA	NA	NA
hsa-miR-452-5p	UBXN10	-2.0200941872388	0.000263136484394317	3.09210197444433	7.28012249492845e-17	mirMAP	-0.385881289717446	1.49659221274655e-32		NA	NA	NA
hsa-miR-18a-5p	UHMK1	-2.29585803678176	4.139318990016e-14	0.532388644879839	0.193869381638698	miRNATAP	-0.254562737421541	1.60229076446917e-11		NA	NA	NA
hsa-miR-452-5p	VEZT	-2.0200941872388	0.000263136484394317	0.597432954819469	0.279677562867709	MirTarget	-0.108713887257831	9.1553293093637e-27		NA	NA	NA
hsa-miR-18a-5p	VPS13D	-2.29585803678176	4.139318990016e-14	0.262837192896914	0.656954489284648	MirTarget	-0.163352521407886	1.25880658562137e-29		NA	NA	NA
hsa-miR-452-5p	WDR35	-2.0200941872388	0.000263136484394317	0.427952554102121	0.328061395829273	MirTarget	-0.105150698402895	1.70887302861035e-15		NA	NA	NA
hsa-miR-18a-5p	XYLT1	-2.29585803678176	4.139318990016e-14	0.0239401352903714	0.956102171778926	MirTarget	-0.113201024754998	1.49525425618871e-05		NA	NA	NA
hsa-miR-18a-5p	ZBTB4	-2.29585803678176	4.139318990016e-14	0.644129464530789	0.315506647558687	MirTarget;miRNATAP	-0.218847139499072	1.58588190258769e-65		NA	NA	NA
hsa-miR-18a-5p	ZBTB47	-2.29585803678176	4.139318990016e-14	0.348865223023341	0.4330815414521	MirTarget	-0.10967547693471	2.2467163994578e-13		NA	NA	NA
hsa-miR-18a-5p	ZCCHC24	-2.29585803678176	4.139318990016e-14	0.940639634957248	0.0782754379791874	MirTarget	-0.332163751402921	1.12163955486112e-47		NA	NA	NA
hsa-miR-18a-5p	ZDHHC15	-2.29585803678176	4.139318990016e-14	-0.233337391259448	0.287055623445757	MirTarget	-0.175569943139667	9.99000475354889e-08		NA	NA	NA
hsa-miR-452-5p	ZFP30	-2.0200941872388	0.000263136484394317	0.186126747844966	0.581953090608353	mirMAP	-0.123668857632649	8.89039560789889e-21		NA	NA	NA
hsa-miR-18a-5p	ZHX3	-2.29585803678176	4.139318990016e-14	0.372360490732096	0.44621242404854	mirMAP	-0.135125456428399	8.09976396484113e-19		NA	NA	NA
hsa-miR-452-5p	ZKSCAN1	-2.0200941872388	0.000263136484394317	0.509801832439897	0.337085023744647	MirTarget	-0.106852170549426	6.37632669942877e-08		NA	NA	NA
hsa-miR-452-5p	ZMAT4	-2.0200941872388	0.000263136484394317	1.92509844376541	4.78758390841727e-07	MirTarget	-0.235747026550811	5.59038861592137e-07		NA	NA	NA
hsa-miR-18a-5p	ZMYND8	-2.29585803678176	4.139318990016e-14	0.599948627037312	0.254720411220156	miRNAWalker2_validate	-0.103030104846277	4.59170526405068e-10		NA	NA	NA
hsa-miR-18a-5p	ZNF365	-2.29585803678176	4.139318990016e-14	1.00295581283367	3.33706198333141e-06	MirTarget	-0.232858888731592	1.45970435051874e-14		NA	NA	NA
hsa-miR-18a-5p	ZNF445	-2.29585803678176	4.139318990016e-14	0.294532655288208	0.507355016281444	mirMAP	-0.109228839358004	1.16702328434072e-20		NA	NA	NA
hsa-miR-224-5p	ZNF516	-2.65799597897592	2.73629620293273e-08	1.33084614400318	0.000678639950321816	mirMAP	-0.158601315685328	2.64263009341449e-18		NA	NA	NA
hsa-miR-452-5p	ZNF516	-2.0200941872388	0.000263136484394317	1.33084614400318	0.000678639950321816	MirTarget	-0.1807599861786	1.4900101495342e-16		NA	NA	NA
hsa-miR-452-5p	ZNF525	-2.0200941872388	0.000263136484394317	0.192586199634253	0.580156676373398	mirMAP	-0.131502479503424	2.87908101419079e-25		NA	NA	NA
hsa-miR-224-5p	ZNF528	-2.65799597897592	2.73629620293273e-08	0.992947769600226	0.00657222197176121	MirTarget	-0.125952746282243	1.29139431800102e-17		NA	NA	NA
hsa-miR-452-5p	ZNF681	-2.0200941872388	0.000263136484394317	0.444029835724288	0.124055998192629	mirMAP	-0.16205399881066	4.53527617414641e-22		NA	NA	NA
hsa-miR-18a-5p	ZNF703	-2.29585803678176	4.139318990016e-14	2.50586372969954	1.76003330852863e-07	miRNAWalker2_validate	-0.407959604276437	3.01410946735778e-28		NA	NA	NA
hsa-miR-18a-5p	ZNF704	-2.29585803678176	4.139318990016e-14	0.67674793166206	0.0568076478498073	miRNATAP	-0.25806685162268	9.87356201874314e-17		NA	NA	NA
hsa-miR-18a-5p	ZNF770	-2.29585803678176	4.139318990016e-14	0.187702765586288	0.705270596983134	miRNAWalker2_validate	-0.110595044268989	1.58179475254364e-11		NA	NA	NA
hsa-miR-224-5p	ZNF785	-2.65799597897592	2.73629620293273e-08	0.636406328694654	0.0757062096629118	mirMAP	-0.112145556590676	1.52405234176756e-31		NA	NA	NA
hsa-miR-224-5p	ZSWIM5	-2.65799597897592	2.73629620293273e-08	1.68872640873898	1.14564018174505e-09	mirMAP	-0.232256946419488	6.4071630082942e-25		NA	NA	NA
hsa-miR-18a-5p	ZSWIM6	-2.29585803678176	4.139318990016e-14	0.459829863607945	0.232476837353956	miRNAWalker2_validate	-0.104021047013898	8.50443666866863e-10		NA	NA	NA