miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106b-5p BMP2 0.50378717276868 1.45412404526866e-05 0.810943012235995 0.000400846574506627 miRNATAP -0.341022043034271 7.17010555502952e-05 NA NA NA hsa-miR-335-3p BMP2 0.336785882180547 0.0542446207938138 0.810943012235995 0.000400846574506627 mirMAP -0.305108734888186 7.77808291656295e-08 NA NA NA hsa-miR-335-5p BMP2 -1.17227779671552 1.49282618530733e-10 0.810943012235995 0.000400846574506627 miRNAWalker2_validate -0.362487274034449 7.09664057344423e-12 NA NA NA hsa-miR-374b-5p BMP2 -0.288413933608091 0.0041474558664058 0.810943012235995 0.000400846574506627 miRNATAP -0.419997341629046 2.6375549374501e-05 NA NA NA hsa-miR-378c BMP2 -1.82618708894602 7.26454201089171e-22 0.810943012235995 0.000400846574506627 miRNATAP -0.213425979987274 2.27749353721347e-05 NA NA NA hsa-miR-429 BMP2 0.559451508722375 0.00563641638673083 0.810943012235995 0.000400846574506627 miRNATAP -0.294389397581455 1.67859900798942e-09 NA NA NA hsa-miR-125a-3p BMP7 0.116035800853173 0.444825559956959 -0.207788367163592 0.492085317732896 miRanda -0.409523894672556 2.14777258614626e-06 NA NA NA hsa-miR-338-3p BMP7 -0.948755228846395 8.99167125682392e-08 -0.207788367163592 0.492085317732896 miRanda -0.211467661617769 0.00394110597349671 NA NA NA hsa-miR-455-5p BMP7 1.408595672323 5.52039116456697e-22 -0.207788367163592 0.492085317732896 miRanda -0.33728890935597 9.29053266616403e-05 NA NA NA hsa-miR-495-3p BMP7 -1.47803501311999 6.88839745293927e-13 -0.207788367163592 0.492085317732896 MirTarget -0.166112298507617 0.00810119906571452 NA NA NA hsa-miR-542-3p BMP7 0.643308814904977 8.81635403230104e-07 -0.207788367163592 0.492085317732896 miRanda;miRNATAP -0.314439291511803 0.00165689155888249 NA NA NA hsa-let-7a-3p CTNNB1 0.0966652362351867 0.423761916840503 -0.300300567639502 0.00163620046474668 MirTarget;miRNATAP -0.133594372296952 0.000109116957423689 NA NA NA hsa-miR-320a CTNNB1 0.801356001806321 4.91397101474502e-09 -0.300300567639502 0.00163620046474668 PITA;miRanda;miRNATAP -0.127056972080136 2.1032822504976e-05 NA NA NA hsa-miR-532-3p CTNNB1 0.80240056676907 1.08989551712617e-09 -0.300300567639502 0.00163620046474668 miRNAWalker2_validate -0.14291782747995 4.05395930207998e-06 NA NA NA hsa-miR-7-1-3p CTNNB1 1.13646121619622 1.49823237535933e-14 -0.300300567639502 0.00163620046474668 mirMAP -0.127239564192006 3.10292737404531e-06 NA NA NA hsa-miR-15a-5p EPB41L5 0.783550182002274 2.60699595655907e-11 -0.491597246817889 8.76254362391411e-05 MirTarget -0.256983489965507 1.65914091456173e-08 NA NA NA hsa-miR-15b-5p EPB41L5 0.85315666454713 3.79816274836297e-12 -0.491597246817889 8.76254362391411e-05 MirTarget -0.127263954900453 0.00376907791982119 NA NA NA hsa-miR-16-1-3p EPB41L5 0.955017760172879 5.95379292601146e-11 -0.491597246817889 8.76254362391411e-05 mirMAP -0.104092644560365 0.00499323702257626 NA NA NA hsa-miR-16-2-3p EPB41L5 1.1567130855258 1.01867256952189e-14 -0.491597246817889 8.76254362391411e-05 mirMAP -0.112828150964183 0.00161401606184246 NA NA NA hsa-miR-17-5p EPB41L5 1.41924888736771 2.75805544953758e-18 -0.491597246817889 8.76254362391411e-05 miRNAWalker2_validate -0.112092989546385 0.000577145093016129 NA NA NA hsa-miR-181a-2-3p EPB41L5 0.562132917934234 4.79313448225408e-05 -0.491597246817889 8.76254362391411e-05 MirTarget -0.140553183008215 0.00037025044475064 NA NA NA hsa-miR-186-5p EPB41L5 0.353452958261612 0.000145058448579496 -0.491597246817889 8.76254362391411e-05 mirMAP -0.207613279503219 0.00045582174845609 NA NA NA hsa-miR-19a-3p EPB41L5 1.35800152353624 2.80940447111944e-12 -0.491597246817889 8.76254362391411e-05 MirTarget;mirMAP -0.103669472435926 0.000167744529072578 NA NA NA hsa-miR-19b-3p EPB41L5 0.538732279378089 0.000622008277870679 -0.491597246817889 8.76254362391411e-05 MirTarget;mirMAP -0.129573253219915 0.000186387895313303 NA NA NA hsa-miR-26b-5p EPB41L5 -0.254478038884324 0.0285227763044636 -0.491597246817889 8.76254362391411e-05 mirMAP -0.139942263868186 0.00319361393263998 NA NA NA hsa-miR-424-5p EPB41L5 1.48125289532143 9.10372985713165e-19 -0.491597246817889 8.76254362391411e-05 MirTarget -0.10618882711216 0.000783081830359803 NA NA NA hsa-miR-505-5p EPB41L5 1.25888458076414 7.80089782306577e-13 -0.491597246817889 8.76254362391411e-05 MirTarget -0.12439165018081 4.33440430047778e-05 NA NA NA hsa-miR-576-5p EPB41L5 0.940432050128373 6.90227595663302e-12 -0.491597246817889 8.76254362391411e-05 MirTarget;PITA -0.1349508258263 0.000587668760656696 NA NA NA hsa-let-7a-3p FGFR2 0.0966652362351867 0.423761916840503 -0.689192404124544 0.00027530593494015 miRNATAP -0.193564939031614 0.00509899325895667 NA NA NA hsa-miR-146b-5p FGFR2 0.917975986853978 3.33749259316025e-09 -0.689192404124544 0.00027530593494015 miRanda -0.315268061524928 1.36606510703905e-09 NA NA NA hsa-miR-186-5p FGFR2 0.353452958261612 0.000145058448579496 -0.689192404124544 0.00027530593494015 miRNAWalker2_validate -0.392401143571198 1.09634780638378e-05 NA NA NA hsa-miR-193a-3p FGFR2 0.22120710726779 0.111827069464729 -0.689192404124544 0.00027530593494015 miRanda -0.357501509299468 1.39512863622931e-09 NA NA NA hsa-miR-330-5p FGFR2 0.944693925383906 5.04972895657346e-13 -0.689192404124544 0.00027530593494015 miRanda -0.214084238420235 0.000567628023207746 NA NA NA hsa-miR-338-3p FGFR2 -0.948755228846395 8.99167125682392e-08 -0.689192404124544 0.00027530593494015 miRanda;miRNATAP -0.175050696307873 0.000145068088792403 NA NA NA hsa-miR-542-3p FGFR2 0.643308814904977 8.81635403230104e-07 -0.689192404124544 0.00027530593494015 miRanda -0.356945364566282 9.9855269919112e-09 NA NA NA hsa-miR-200b-3p FOXF2 0.0717138787925347 0.682858087587209 1.76695250261327 1.86791889221365e-19 TargetScan -0.284265031012315 1.2934943717218e-08 25798833 The miR 200 family and the miR 183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers; We therefore identified a novel mechanism whereby the miR-200 family and the miR-183~96~182 cluster inhibit lung cancer invasion and metastasis by targeting Foxf2 metastasis lung cancer hsa-miR-26b-5p FOXF2 -0.254478038884324 0.0285227763044636 1.76695250261327 1.86791889221365e-19 miRNAWalker2_validate -0.317235385619018 3.20710151380275e-05 NA NA NA hsa-miR-429 FOXF2 0.559451508722375 0.00563641638673083 1.76695250261327 1.86791889221365e-19 PITA;miRanda;miRNATAP -0.156948799965956 0.000320044976888047 NA NA NA hsa-miR-146b-5p GSK3B 0.917975986853978 3.33749259316025e-09 0.343238217842623 0.000162620715851218 miRanda -0.132473733778903 1.22425435698654e-07 NA NA NA hsa-miR-155-5p GSK3B 0.533437622040649 0.00248671179205372 0.343238217842623 0.000162620715851218 miRNAWalker2_validate;miRNATAP -0.129703405382586 5.34297193283262e-09 NA NA NA hsa-miR-181a-5p GSK3B 0.819060835827404 1.38616688310277e-13 0.343238217842623 0.000162620715851218 mirMAP -0.129983989338606 0.00022139654686707 NA NA NA hsa-miR-181c-5p GSK3B -0.168991199007857 0.196949106150297 0.343238217842623 0.000162620715851218 mirMAP -0.100996413243857 0.000916035275097975 NA NA NA hsa-miR-19b-3p GSK3B 0.538732279378089 0.000622008277870679 0.343238217842623 0.000162620715851218 mirMAP -0.150537422390616 1.39629849063498e-09 NA NA NA hsa-miR-26b-5p GSK3B -0.254478038884324 0.0285227763044636 0.343238217842623 0.000162620715851218 miRNATAP -0.183171373213342 7.56842885965509e-08 NA NA NA hsa-miR-29b-3p GSK3B -0.110721443686039 0.511264554091106 0.343238217842623 0.000162620715851218 miRTarBase;miRNATAP -0.15553953034104 2.18389788804596e-11 NA NA NA hsa-miR-30d-3p GSK3B -0.577371911152798 2.02950840095287e-06 0.343238217842623 0.000162620715851218 miRNATAP -0.131426620771029 5.32900605744827e-05 NA NA NA hsa-miR-320a GSK3B 0.801356001806321 4.91397101474502e-09 0.343238217842623 0.000162620715851218 miRanda;mirMAP -0.118878412659656 3.17737768709188e-05 NA NA NA hsa-miR-342-3p GSK3B 0.99756868977753 9.28499866272332e-10 0.343238217842623 0.000162620715851218 miRanda -0.148362741070108 3.75779017463144e-10 NA NA NA hsa-miR-362-5p GSK3B 0.41089772861323 0.0404254902071382 0.343238217842623 0.000162620715851218 miRNATAP -0.127816847863223 5.47709912360141e-11 NA NA NA hsa-miR-374a-5p GSK3B -0.621903385111545 6.61791773205282e-12 0.343238217842623 0.000162620715851218 mirMAP -0.147719372342419 0.000672011632138884 NA NA NA hsa-miR-374b-5p GSK3B -0.288413933608091 0.0041474558664058 0.343238217842623 0.000162620715851218 mirMAP -0.228003781574329 6.67084161350237e-09 NA NA NA hsa-miR-664a-3p GSK3B -0.256108763664991 0.0513188660751664 0.343238217842623 0.000162620715851218 mirMAP -0.163651290979419 5.20958641528547e-08 NA NA NA hsa-let-7a-3p HGF 0.0966652362351867 0.423761916840503 -0.628808099278418 0.0248850412356301 mirMAP -0.678925182790585 1.16230629525026e-11 NA NA NA hsa-miR-141-3p HGF 0.730011517758706 0.000120338355004032 -0.628808099278418 0.0248850412356301 MirTarget;TargetScan -0.561125900874801 1.20618910138091e-19 NA NA NA hsa-miR-200a-3p HGF 0.607140814457753 0.00289840524858752 -0.628808099278418 0.0248850412356301 MirTarget -0.46418885165035 1.63121170062695e-15 NA NA NA hsa-miR-203a-3p HGF 0.0441399794719697 0.880456392176704 -0.628808099278418 0.0248850412356301 MirTarget -0.321186869823737 2.52059425443943e-15 NA NA NA hsa-miR-224-3p HGF 0.502645536188015 0.0081142387260641 -0.628808099278418 0.0248850412356301 mirMAP -0.382701156821044 2.14724084930058e-09 NA NA NA hsa-miR-26b-5p HGF -0.254478038884324 0.0285227763044636 -0.628808099278418 0.0248850412356301 MirTarget;miRNATAP -0.293463586038775 0.00556150652071372 NA NA NA hsa-miR-29a-5p HGF 0.323252792625584 0.0370417231222825 -0.628808099278418 0.0248850412356301 mirMAP -0.33517175543393 2.02072168292234e-05 NA NA NA hsa-miR-30b-5p HGF -0.400238605368173 0.00346540992719245 -0.628808099278418 0.0248850412356301 mirMAP -0.339568782547391 0.000139133814424322 NA NA NA hsa-miR-30c-5p HGF 0.021222006155897 0.886366656528128 -0.628808099278418 0.0248850412356301 mirMAP -0.364505623339003 9.30153464059718e-06 NA NA NA hsa-miR-33a-3p HGF 0.20371038027126 0.212335697664505 -0.628808099278418 0.0248850412356301 mirMAP -0.245106862650746 0.0012734452978666 NA NA NA hsa-miR-429 HGF 0.559451508722375 0.00563641638673083 -0.628808099278418 0.0248850412356301 miRanda -0.406558130985217 6.89356985764421e-12 NA NA NA hsa-miR-590-5p HGF 0.763025362395968 3.65305892505623e-09 -0.628808099278418 0.0248850412356301 miRanda -0.578847824892088 3.36079943237795e-10 NA NA NA hsa-miR-651-5p HGF 0.504713329111777 0.00155970216047171 -0.628808099278418 0.0248850412356301 MirTarget -0.32162676958462 2.46985420767702e-05 NA NA NA hsa-miR-7-1-3p HGF 1.13646121619622 1.49823237535933e-14 -0.628808099278418 0.0248850412356301 mirMAP -0.279818488965689 0.000518564555493889 NA NA NA hsa-miR-944 HGF 1.47323925060177 2.61626403984929e-13 -0.628808099278418 0.0248850412356301 mirMAP -0.331250406167246 1.57938016792516e-08 NA NA NA hsa-miR-106a-5p HIF1A 0.67978010057847 0.00221925869726092 0.669817670907295 4.04045371604487e-06 MirTarget -0.137115422426195 1.39355599414074e-06 NA NA NA hsa-miR-106b-5p HIF1A 0.50378717276868 1.45412404526866e-05 0.669817670907295 4.04045371604487e-06 MirTarget -0.223349543954752 4.34799162298509e-05 NA NA NA hsa-miR-139-5p HIF1A -1.46099200329485 7.85040381494472e-22 0.669817670907295 4.04045371604487e-06 miRanda -0.14857437469501 0.00021959685216009 NA NA NA hsa-miR-155-5p HIF1A 0.533437622040649 0.00248671179205372 0.669817670907295 4.04045371604487e-06 MirTarget -0.166095452335493 3.6975721543014e-06 NA NA NA hsa-miR-16-2-3p HIF1A 1.1567130855258 1.01867256952189e-14 0.669817670907295 4.04045371604487e-06 MirTarget;mirMAP -0.155181425894773 0.000187446199797176 NA NA NA hsa-miR-195-3p HIF1A -0.624259620429699 0.000164279659144497 0.669817670907295 4.04045371604487e-06 MirTarget -0.175041579623075 4.99936198652015e-06 NA NA NA hsa-miR-199b-5p HIF1A -1.08432682485992 7.68241801134089e-10 0.669817670907295 4.04045371604487e-06 miRNAWalker2_validate;miRTarBase;MirTarget;PITA;miRanda -0.11461751152829 0.00128710247227163 NA NA NA hsa-miR-20a-5p HIF1A 1.1531986665452 1.02385132917958e-11 0.669817670907295 4.04045371604487e-06 miRNAWalker2_validate;miRTarBase;MirTarget -0.116299660018667 0.00162371994354084 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-20b-5p HIF1A 0.345967670847176 0.232014828043601 0.669817670907295 4.04045371604487e-06 miRNAWalker2_validate;miRTarBase;MirTarget -0.152996396065526 1.46287359054023e-12 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-217 HIF1A -1.35391381055929 2.42394951427902e-09 0.669817670907295 4.04045371604487e-06 miRanda -0.183594478859186 1.44847944599925e-11 NA NA NA hsa-miR-320a HIF1A 0.801356001806321 4.91397101474502e-09 0.669817670907295 4.04045371604487e-06 miRanda -0.230969351823761 4.30112041238924e-07 NA NA NA hsa-miR-338-3p HIF1A -0.948755228846395 8.99167125682392e-08 0.669817670907295 4.04045371604487e-06 MirTarget;PITA;miRanda -0.190220299615109 6.54196374682613e-08 NA NA NA hsa-miR-582-3p HIF1A -0.248056267546012 0.143798829508405 0.669817670907295 4.04045371604487e-06 PITA -0.233016344117027 3.43396124378489e-10 NA NA NA hsa-miR-582-5p HIF1A -0.0366995972742474 0.821827119138923 0.669817670907295 4.04045371604487e-06 MirTarget;PITA;miRNATAP -0.219823611189094 1.51379253741892e-08 NA NA NA hsa-miR-660-5p HIF1A -0.202705992887645 0.101093376073573 0.669817670907295 4.04045371604487e-06 MirTarget -0.302515707563253 3.56530783679055e-09 NA NA NA hsa-miR-93-5p HIF1A 1.61042951896619 5.1280369606967e-24 0.669817670907295 4.04045371604487e-06 MirTarget -0.136543492976145 0.00035313377854799 NA NA NA hsa-let-7a-5p HMGA2 -0.439381775414001 3.1119785480023e-05 4.45669314139083 6.73354275393639e-30 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.767279337434585 7.45015347476901e-06 20949044;18413822;23073586;21598109;24612219;23134218;23700794;21412931 Since let-7 miRNAs generally play a tumor-suppressive role as targeting oncogenes such as RAS and HMGA2 our results suggest that AZ-P7a cells release let-7 miRNAs via exosomes into the extracellular environment to maintain their oncogenesis;Recent studies report that HMGA2 is negatively regulated by the let-7 microRNA miRNA family; However no studies have examined the clinical significance of HMGA2 and its relationship to the let-7 miRNA family in gastric cancer; We also did an association study comparing HMGA2 expression and let-7 miRNA family expression in gastric cancer; An inverse correlation between HMGA2 and let-7a was found in gastric cancer cell lines P = 0.08; Furthermore our findings suggest that HMGA2 is negatively regulated by the let-7 miRNA family in human gastric cancer;HMGA2 mRNA and let-7 family microRNA were detected by real time fluorescent quantitative reverse transcription polymerase chain reaction in the corresponding frozen tissues; All let-7 family members were detectable in all ovarian cancer samples and their expression were inversely correlated with HMGA2 mRNA expression r=-0.305P<0.05; The downregulation of let-7 is but not the only mechanism of HMGA2 overexpression in serous ovarian cancer;Role of microRNA let 7 and effect to HMGA2 in esophageal squamous cell carcinoma; To investigated the role of microRNA miRNA let-7 and its regulation on high mobility group A2 HMGA2 protein expression in esophageal squamous cell carcinoma ESCC; To evaluate the role of let-7 and HMGA2 cell proliferations were analyzed with synthetic let-7 mimics- or its inhibitor-transfected cells; The transcription of let-7 inversely correlated with HMGA2 protein; The present results demonstrated that let-7 and HMGA2 involved in ESCC carcinogenesis;HMGA2 is down regulated by microRNA let 7 and associated with epithelial mesenchymal transition in oesophageal squamous cell carcinomas of Kazakhs; To investigate the expression of let-7 and its regulation of high-mobility group A2 protein HMGA2 and to verify the relationship between let-7 HMGA2 and the process of epithelial-mesenchymal transition EMT in oesophageal squamous cell carcinomas OSCC of Kazakh patients; Let-7 could repress expression of HMGA2 after co-transfection with let-7 and HMGA2 P = 0.002; Moreover let-7 expression was observed less frequently P = 2.0 × 10-8 and HMGA2 expression more frequently P = 1.0 × 10-10 in OSCC than in normal adjacent tissues; and let-7 expression was observed less frequently in OSCC from Kazakh patients than in those from Han and Uygur patients P = 0.041; There was a reverse correlation between expression of let-7 and HMGA2 P = 0.018; Expression of let-7 can suppress cell proliferation by acting directly on regulation of HMGA2 in OSCC;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells;Let 7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data; The aim of our study was first to assess the role of HMGA2 expression in the pathogenesis of adipocytic tumors AT and second to seek a potential correlation between overexpression of HMGA2 and let-7 expression inhibition by analyzing a series of 56 benign and malignant AT with molecular cytogenetic data; We measured the levels of expression of HMGA2 mRNA and of eight members of the let-7 microRNA family using quantitative RT-PCR and expression of HMGA2 protein using immunohistochemistry; Although overexpression of both HMGA2 mRNA and protein in a majority of ordinary lipomas without HMGA2 structural rearrangement may have suggested a potential role for let-7 microRNAs we did not observe a significant link with let-7 inhibition in such cases ;;;tumorigenesis;;;;malignant trasformation gastric cancer;gastric cancer;ovarian cancer;esophageal cancer;esophageal cancer;lung squamous cell cancer;lung cancer;sarcoma hsa-let-7b-5p HMGA2 -0.2489842756826 0.0211384499461719 4.45669314139083 6.73354275393639e-30 miRNAWalker2_validate;miRTarBase;MirTarget -0.691388425103243 4.04231698451336e-05 20949044;18413822;23073586;21598109;24612219;23700794;21412931 Since let-7 miRNAs generally play a tumor-suppressive role as targeting oncogenes such as RAS and HMGA2 our results suggest that AZ-P7a cells release let-7 miRNAs via exosomes into the extracellular environment to maintain their oncogenesis;Recent studies report that HMGA2 is negatively regulated by the let-7 microRNA miRNA family; However no studies have examined the clinical significance of HMGA2 and its relationship to the let-7 miRNA family in gastric cancer; We also did an association study comparing HMGA2 expression and let-7 miRNA family expression in gastric cancer; Furthermore our findings suggest that HMGA2 is negatively regulated by the let-7 miRNA family in human gastric cancer;HMGA2 mRNA and let-7 family microRNA were detected by real time fluorescent quantitative reverse transcription polymerase chain reaction in the corresponding frozen tissues; All let-7 family members were detectable in all ovarian cancer samples and their expression were inversely correlated with HMGA2 mRNA expression r=-0.305P<0.05; The downregulation of let-7 is but not the only mechanism of HMGA2 overexpression in serous ovarian cancer;Role of microRNA let 7 and effect to HMGA2 in esophageal squamous cell carcinoma; To investigated the role of microRNA miRNA let-7 and its regulation on high mobility group A2 HMGA2 protein expression in esophageal squamous cell carcinoma ESCC; To evaluate the role of let-7 and HMGA2 cell proliferations were analyzed with synthetic let-7 mimics- or its inhibitor-transfected cells; The transcription of let-7 inversely correlated with HMGA2 protein; The present results demonstrated that let-7 and HMGA2 involved in ESCC carcinogenesis;HMGA2 is down regulated by microRNA let 7 and associated with epithelial mesenchymal transition in oesophageal squamous cell carcinomas of Kazakhs; To investigate the expression of let-7 and its regulation of high-mobility group A2 protein HMGA2 and to verify the relationship between let-7 HMGA2 and the process of epithelial-mesenchymal transition EMT in oesophageal squamous cell carcinomas OSCC of Kazakh patients; Let-7 could repress expression of HMGA2 after co-transfection with let-7 and HMGA2 P = 0.002; Moreover let-7 expression was observed less frequently P = 2.0 × 10-8 and HMGA2 expression more frequently P = 1.0 × 10-10 in OSCC than in normal adjacent tissues; and let-7 expression was observed less frequently in OSCC from Kazakh patients than in those from Han and Uygur patients P = 0.041; There was a reverse correlation between expression of let-7 and HMGA2 P = 0.018; Expression of let-7 can suppress cell proliferation by acting directly on regulation of HMGA2 in OSCC;MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells;Let 7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data; The aim of our study was first to assess the role of HMGA2 expression in the pathogenesis of adipocytic tumors AT and second to seek a potential correlation between overexpression of HMGA2 and let-7 expression inhibition by analyzing a series of 56 benign and malignant AT with molecular cytogenetic data; We measured the levels of expression of HMGA2 mRNA and of eight members of the let-7 microRNA family using quantitative RT-PCR and expression of HMGA2 protein using immunohistochemistry; Although overexpression of both HMGA2 mRNA and protein in a majority of ordinary lipomas without HMGA2 structural rearrangement may have suggested a potential role for let-7 microRNAs we did not observe a significant link with let-7 inhibition in such cases ;;;tumorigenesis;;;malignant trasformation gastric cancer;gastric cancer;ovarian cancer;esophageal cancer;esophageal cancer;lung cancer;sarcoma hsa-let-7c-5p HMGA2 -2.07953368242668 3.46048888391218e-23 4.45669314139083 6.73354275393639e-30 miRNAWalker2_validate;miRTarBase;MirTarget -0.806534505069892 1.97059168844052e-24 NA NA NA hsa-let-7f-5p HMGA2 -0.441845198213823 0.00242957484218694 4.45669314139083 6.73354275393639e-30 miRNAWalker2_validate;MirTarget -0.347051022079953 0.00531020669613986 NA NA NA hsa-let-7g-5p HMGA2 -0.250780249469264 0.00939610188330072 4.45669314139083 6.73354275393639e-30 miRNAWalker2_validate;miRTarBase;MirTarget -0.74644926991967 7.75936678734911e-05 21472347;18308936 Furthermore K-Ras and HMGA2 are well known as targets of let-7g; In this study we evaluated the potential role of precursor pre-let-7g in lung cancer cell metastasis focusing on the two targets of let-7g HMGA2 and K-Ras;In let-7g expressing tumors reductions in Ras family and HMGA2 protein levels were detected; Ectopic expression of K-RasG12D largely rescued let-7g mediated tumor suppression whereas ectopic expression of HMGA2 was less effective metastasis; lung cancer;lung cancer hsa-miR-125b-2-3p HMGA2 -1.87765459914049 1.24704155651697e-13 4.45669314139083 6.73354275393639e-30 mirMAP -0.599672774947008 6.43066358581415e-19 NA NA NA hsa-miR-125b-5p HMGA2 -0.993460109818276 5.07736727659894e-12 4.45669314139083 6.73354275393639e-30 miRNAWalker2_validate;miRTarBase -0.872723332276466 6.10970209720732e-13 NA NA NA hsa-miR-148a-5p HMGA2 -1.00478606532747 1.38045244999229e-07 4.45669314139083 6.73354275393639e-30 mirMAP -0.523038517814871 1.85520060076771e-08 NA NA NA hsa-miR-195-3p HMGA2 -0.624259620429699 0.000164279659144497 4.45669314139083 6.73354275393639e-30 mirMAP -0.725637328373556 1.63618840176472e-11 NA NA NA hsa-miR-195-5p HMGA2 -1.8367376818177 6.9944883988895e-31 4.45669314139083 6.73354275393639e-30 MirTarget -0.819173795732359 5.773484084711e-15 NA NA NA hsa-miR-199a-5p HMGA2 -0.364835768178638 0.0435119211101981 4.45669314139083 6.73354275393639e-30 miRanda -0.275403367704305 0.00610524579591463 NA NA NA hsa-miR-199b-5p HMGA2 -1.08432682485992 7.68241801134089e-10 4.45669314139083 6.73354275393639e-30 miRanda -0.406043346525521 5.75094161893386e-05 NA NA NA hsa-miR-20b-5p HMGA2 0.345967670847176 0.232014828043601 4.45669314139083 6.73354275393639e-30 miRNATAP -0.307766242278935 7.47592102369256e-07 NA NA NA hsa-miR-23b-3p HMGA2 -0.497563803223134 3.31483353357535e-05 4.45669314139083 6.73354275393639e-30 mirMAP -1.06526143657057 6.29790009739926e-13 NA NA NA hsa-miR-26a-5p HMGA2 -1.09269574587169 1.24020612216319e-22 4.45669314139083 6.73354275393639e-30 miRNAWalker2_validate;miRTarBase;miRNATAP -1.05161832046561 8.02917727136433e-12 24682444 Furthermore we demonstrated that high mobility group AT-hook 2 HMGA2 was a direct target of miR-26a; The results showed that HMGA2 mRNA levels and miR-26a levels were negatively correlated; In addition we confirmed that reintroduction of HMGA2 antagonized the inhibition of miR-26a to GBC cell proliferation and all these effects were achieved through the cell cycle; Together all these results suggest that miR-26a expression contributes to GBC proliferation by targeting HMGA2 miR-26a shows promise as a prognosis factor and therapeutic target of GBC patients worse prognosis bladder cancer hsa-miR-29b-2-5p HMGA2 -0.502720326849742 0.000730448246894952 4.45669314139083 6.73354275393639e-30 mirMAP -0.584885614571135 1.29765650281039e-06 NA NA NA hsa-miR-30a-3p HMGA2 -2.26144364746452 8.12421214153823e-31 4.45669314139083 6.73354275393639e-30 MirTarget -0.514231578446967 2.24499877403303e-09 NA NA NA hsa-miR-30a-5p HMGA2 -1.79779915425811 1.93360169837799e-26 4.45669314139083 6.73354275393639e-30 mirMAP -0.615108101185708 1.0013099700026e-09 NA NA NA hsa-miR-30b-5p HMGA2 -0.400238605368173 0.00346540992719245 4.45669314139083 6.73354275393639e-30 mirMAP -0.391922741594788 0.00311827075770731 NA NA NA hsa-miR-30d-3p HMGA2 -0.577371911152798 2.02950840095287e-06 4.45669314139083 6.73354275393639e-30 MirTarget -0.577014479735653 0.000102105825776101 NA NA NA hsa-miR-30d-5p HMGA2 -0.38399848121878 0.000171129616944749 4.45669314139083 6.73354275393639e-30 mirMAP -0.916535323743468 2.11860119813698e-07 NA NA NA hsa-miR-30e-3p HMGA2 -0.890635378639789 1.65740480611339e-16 4.45669314139083 6.73354275393639e-30 MirTarget -1.37773413661885 4.43836162945141e-18 NA NA NA hsa-miR-30e-5p HMGA2 -1.02114836019762 6.81961221797866e-17 4.45669314139083 6.73354275393639e-30 mirMAP -1.27539430690017 5.81942504308282e-20 NA NA NA hsa-miR-337-3p HMGA2 -1.70091836051933 1.39844536073221e-13 4.45669314139083 6.73354275393639e-30 MirTarget;PITA -0.221747768144724 0.00394222082620597 NA NA NA hsa-miR-340-5p HMGA2 -0.608415693437977 4.44345153563513e-05 4.45669314139083 6.73354275393639e-30 mirMAP -0.340606377991935 0.00498062871245901 NA NA NA hsa-miR-34a-5p HMGA2 -0.117372471043915 0.364001947180738 4.45669314139083 6.73354275393639e-30 miRNAWalker2_validate -0.562179871493631 6.3475156812021e-05 18803879 miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making poor survival;differentiation gastric cancer hsa-miR-381-3p HMGA2 -2.21357103508055 2.33039447871705e-24 4.45669314139083 6.73354275393639e-30 mirMAP -0.230970155746285 0.00370009996135725 NA NA NA hsa-miR-491-5p HMGA2 -0.541680329196715 0.00135829217561865 4.45669314139083 6.73354275393639e-30 PITA;miRanda -0.329740380355764 0.00325839492784468 NA NA NA hsa-miR-497-5p HMGA2 -0.966244470847844 5.26505649147857e-12 4.45669314139083 6.73354275393639e-30 MirTarget -0.944887976209222 2.8689194152602e-14 NA NA NA hsa-miR-532-5p HMGA2 -0.021857649390892 0.830992272120134 4.45669314139083 6.73354275393639e-30 mirMAP -0.583280932634989 0.00110658177646052 NA NA NA hsa-miR-664a-3p HMGA2 -0.256108763664991 0.0513188660751664 4.45669314139083 6.73354275393639e-30 mirMAP -0.48225892689875 0.000489112416746478 NA NA NA hsa-miR-664a-5p HMGA2 -0.871809752100072 1.86842520324979e-08 4.45669314139083 6.73354275393639e-30 MirTarget -0.557050731768997 1.32920444175119e-06 NA NA NA hsa-let-7a-3p LEF1 0.0966652362351867 0.423761916840503 0.488266783568626 0.0110933059149055 miRNATAP -0.275840196352323 7.4673475039569e-05 NA NA NA hsa-miR-193b-3p LEF1 1.72788400801602 3.0722151264559e-21 0.488266783568626 0.0110933059149055 miRNAWalker2_validate -0.311745236740014 5.46005978515826e-13 NA NA NA hsa-miR-455-5p LEF1 1.408595672323 5.52039116456697e-22 0.488266783568626 0.0110933059149055 miRanda -0.211162394314959 0.000123308773316749 NA NA NA hsa-let-7a-3p LIMS1 0.0966652362351867 0.423761916840503 0.196981967170581 0.256339758558295 mirMAP -0.331594740909367 1.03365312483823e-07 NA NA NA hsa-miR-140-5p LIMS1 -0.412389003031485 0.000136051708543369 0.196981967170581 0.256339758558295 miRanda -0.196651752124199 0.0049910458846648 NA NA NA hsa-miR-148b-5p LIMS1 1.1533193737265 7.26420964688337e-13 0.196981967170581 0.256339758558295 MirTarget -0.308026705044953 1.68281227710862e-11 NA NA NA hsa-miR-182-5p LIMS1 1.15060905311096 6.25565852529946e-10 0.196981967170581 0.256339758558295 MirTarget;miRNATAP -0.169674826524508 1.9645658845397e-05 NA NA NA hsa-miR-186-5p LIMS1 0.353452958261612 0.000145058448579496 0.196981967170581 0.256339758558295 mirMAP -0.499940727296657 5.33523173444345e-10 NA NA NA hsa-miR-18a-3p LIMS1 1.82583720936229 7.51297960972179e-19 0.196981967170581 0.256339758558295 miRNAWalker2_validate -0.151942072962216 2.70136009980645e-05 NA NA NA hsa-miR-193a-3p LIMS1 0.22120710726779 0.111827069464729 0.196981967170581 0.256339758558295 MirTarget;miRanda -0.157729187651716 0.00379093775828519 NA NA NA hsa-miR-205-3p LIMS1 1.2960640797621 5.80786479909147e-11 0.196981967170581 0.256339758558295 MirTarget -0.113196815450021 0.00249415968369675 NA NA NA hsa-miR-222-3p LIMS1 1.08197052578759 2.32604040301699e-14 0.196981967170581 0.256339758558295 MirTarget -0.206871241371027 6.6405976394799e-05 NA NA NA hsa-miR-29b-3p LIMS1 -0.110721443686039 0.511264554091106 0.196981967170581 0.256339758558295 MirTarget;miRNATAP -0.444164433071028 3.76840017350148e-25 NA NA NA hsa-miR-30a-5p LIMS1 -1.79779915425811 1.93360169837799e-26 0.196981967170581 0.256339758558295 MirTarget -0.188428095237781 8.26629435912502e-06 NA NA NA hsa-miR-30b-5p LIMS1 -0.400238605368173 0.00346540992719245 0.196981967170581 0.256339758558295 MirTarget -0.521070234871774 7.58803925567735e-23 NA NA NA hsa-miR-30c-5p LIMS1 0.021222006155897 0.886366656528128 0.196981967170581 0.256339758558295 MirTarget -0.531846441118519 4.78182992000005e-28 NA NA NA hsa-miR-30d-3p LIMS1 -0.577371911152798 2.02950840095287e-06 0.196981967170581 0.256339758558295 mirMAP -0.418453228835606 6.31005524694163e-12 NA NA NA hsa-miR-30e-5p LIMS1 -1.02114836019762 6.81961221797866e-17 0.196981967170581 0.256339758558295 MirTarget -0.263732743356249 1.04297245138516e-05 NA NA NA hsa-miR-3607-3p LIMS1 1.01377165357363 9.13355519701165e-05 0.196981967170581 0.256339758558295 mirMAP -0.197087630366633 4.115382572683e-12 NA NA NA hsa-miR-374a-3p LIMS1 -0.299190081500425 0.00682975596757891 0.196981967170581 0.256339758558295 mirMAP -0.311503107899293 4.98596486136845e-06 NA NA NA hsa-miR-429 LIMS1 0.559451508722375 0.00563641638673083 0.196981967170581 0.256339758558295 miRanda;miRNATAP -0.251037928599039 6.96685500924161e-12 NA NA NA hsa-miR-505-3p LIMS1 0.912823669571645 4.0549774967148e-13 0.196981967170581 0.256339758558295 miRNAWalker2_validate;MirTarget -0.28987966627399 7.04510435651754e-07 NA NA NA hsa-miR-576-5p LIMS1 0.940432050128373 6.90227595663302e-12 0.196981967170581 0.256339758558295 mirMAP -0.409097073237989 9.64652012717877e-15 NA NA NA hsa-miR-590-3p LIMS1 0.221436901462551 0.0965904764063157 0.196981967170581 0.256339758558295 miRNAWalker2_validate;miRanda -0.203184468568815 0.000345935864832815 NA NA NA hsa-miR-7-1-3p LIMS1 1.13646121619622 1.49823237535933e-14 0.196981967170581 0.256339758558295 mirMAP -0.281081519416842 1.19320529918103e-08 NA NA NA hsa-miR-96-5p LIMS1 1.42326703011157 4.39736150032373e-14 0.196981967170581 0.256339758558295 TargetScan;miRNATAP -0.193408966099288 6.01321937867774e-07 NA NA NA hsa-miR-338-3p LOXL2 -0.948755228846395 8.99167125682392e-08 3.11520878428279 3.71623410797103e-42 miRanda -0.32979386647561 3.5783647607291e-08 NA NA NA hsa-miR-362-5p LOXL3 0.41089772861323 0.0404254902071382 1.33194145633351 4.48834487377549e-14 TargetScan -0.117836960346783 0.0027143395782194 NA NA NA hsa-miR-148a-3p NOG -0.428944290834563 0.00954246923521465 -0.811778860783982 0.0281306008173116 MirTarget;miRNATAP -0.340970882819345 0.000455128131623632 NA NA NA hsa-miR-148b-3p NOG 0.386859166050437 4.6728211830726e-06 -0.811778860783982 0.0281306008173116 MirTarget -0.755030334164609 8.0253552829174e-05 NA NA NA hsa-miR-200b-3p NOG 0.0717138787925347 0.682858087587209 -0.811778860783982 0.0281306008173116 MirTarget;TargetScan -0.798145848379199 3.092687507391e-19 NA NA NA hsa-miR-200c-3p NOG 0.630251054099546 0.000131975031451555 -0.811778860783982 0.0281306008173116 MirTarget;miRNATAP -0.704877584165436 1.41878662193602e-13 NA NA NA hsa-miR-429 NOG 0.559451508722375 0.00563641638673083 -0.811778860783982 0.0281306008173116 MirTarget;PITA;miRanda;miRNATAP -0.537340412474035 6.2512711352738e-12 NA NA NA hsa-miR-18a-3p NOTCH1 1.82583720936229 7.51297960972179e-19 -0.0951582732785692 0.544770600265035 MirTarget -0.114041788799566 0.000515752427990463 NA NA NA hsa-miR-199b-5p NOTCH1 -1.08432682485992 7.68241801134089e-10 -0.0951582732785692 0.544770600265035 miRanda -0.105253716748154 0.00583492121051834 24659709 Epigenetic silencing of microRNA 199b 5p is associated with acquired chemoresistance via activation of JAG1 Notch1 signaling in ovarian cancer; Here we report that the loss of miR-199b-5p due to progressive epigenetic silencing leads to the activation of the JAG1-mediated Notch1 signaling cascade thereby leading to the development of acquired chemoresistance in ovarian cancer drug resistance;progression ovarian cancer hsa-miR-2355-5p NOTCH1 1.47205546931107 8.65192179636668e-19 -0.0951582732785692 0.544770600265035 MirTarget -0.227115092193576 7.10496255532034e-09 NA NA NA hsa-miR-30b-5p NOTCH1 -0.400238605368173 0.00346540992719245 -0.0951582732785692 0.544770600265035 miRNATAP -0.12930046160451 0.00970376230488635 NA NA NA hsa-miR-30c-5p NOTCH1 0.021222006155897 0.886366656528128 -0.0951582732785692 0.544770600265035 miRNATAP -0.157244812009156 0.000652306597298979 23974200 We identified NOTCH1 as a direct target of miR-30c; Finally a block of miR-30c prevents C/EBPα-induced downregulation of Notch1 protein and leads to a reduced CD11b expression in myeloid differentiation; Our study presents the first evidence that C/EBPα miR-30c and Notch1 together play a critical role in granulocytic differentiation and AML and particularly in AML with CEBPA mutations differentiation acute myeloid leukemia hsa-miR-26b-5p SNAI1 -0.254478038884324 0.0285227763044636 0.614810109856072 0.000592031328807351 miRNAWalker2_validate -0.202024097506673 0.00285231830693582 NA NA NA hsa-miR-30b-5p SNAI1 -0.400238605368173 0.00346540992719245 0.614810109856072 0.000592031328807351 miRTarBase;miRNATAP -0.244842131957848 1.71526825135873e-05 NA NA NA hsa-miR-30c-5p SNAI1 0.021222006155897 0.886366656528128 0.614810109856072 0.000592031328807351 miRTarBase;miRNATAP -0.199734116783483 0.000153927589814907 NA NA NA hsa-miR-30d-5p SNAI1 -0.38399848121878 0.000171129616944749 0.614810109856072 0.000592031328807351 miRTarBase;miRNATAP -0.248339522053962 0.00122752043862076 26501435 miR 30d Blocked Transforming Growth Factor β1 Induced Epithelial Mesenchymal Transition by Targeting Snail in Ovarian Cancer Cells; Luciferase activity assay was performed to verify the direct inhibition of Snail by miR-30d; Furthermore Snail was identified as the direct target of miR-30d; Our results revealed that miR-30d functioned as a suppressor of ovarian cancer progression by decreasing Snail expression and thus blocking TGF-β1-induced EMT process suggesting the potentiality of miR-30d analogs to be used as therapeutics for ovarian cancer progression ovarian cancer hsa-miR-30e-5p SNAI1 -1.02114836019762 6.81961221797866e-17 0.614810109856072 0.000592031328807351 miRTarBase -0.315040364699602 3.47295397152763e-07 NA NA NA hsa-miR-590-5p SNAI1 0.763025362395968 3.65305892505623e-09 0.614810109856072 0.000592031328807351 miRanda -0.257587046234427 1.53698046765781e-05 NA NA NA hsa-miR-107 SNAI2 -0.0447040564279497 0.671618791096755 1.57363779849313 5.91219248669788e-24 miRanda -0.284005615551857 2.80975142738815e-05 NA NA NA hsa-miR-126-5p SNAI2 -0.953529188793816 7.91719143295591e-16 1.57363779849313 5.91219248669788e-24 MirTarget -0.28956153342037 6.59691839147703e-07 NA NA NA hsa-miR-140-5p SNAI2 -0.412389003031485 0.000136051708543369 1.57363779849313 5.91219248669788e-24 miRanda -0.309663243070182 2.27741612376817e-06 25322669;27597739 Down regulation of miR 140 induces EMT and promotes invasion by targeting Slug in esophageal cancer; Slug a target gene of miR-140 was examined by luciferase assay and Western blot; miR-140 may regulate the cell invasion of EC via controlling Slug expression;Mechanistically Unigene56159 could directly bind to miR-140-5p and effectively act as a competing endogenous RNA ceRNA for miR-140-5p to de-repress the expression of the target gene Slug ; esophageal cancer;liver cancer hsa-miR-148b-3p SNAI2 0.386859166050437 4.6728211830726e-06 1.57363779849313 5.91219248669788e-24 miRNAWalker2_validate -0.281196118743247 0.000887546987344902 NA NA NA hsa-miR-200b-3p SNAI2 0.0717138787925347 0.682858087587209 1.57363779849313 5.91219248669788e-24 TargetScan -0.308386885932541 7.03084214359139e-15 NA NA NA hsa-miR-200c-3p SNAI2 0.630251054099546 0.000131975031451555 1.57363779849313 5.91219248669788e-24 miRNATAP -0.134398114048252 0.00174621077363836 NA NA NA hsa-miR-330-3p SNAI2 -0.0524949332825773 0.719856123539461 1.57363779849313 5.91219248669788e-24 PITA -0.130033682964608 0.00780041280539171 NA NA NA hsa-miR-335-3p SNAI2 0.336785882180547 0.0542446207938138 1.57363779849313 5.91219248669788e-24 mirMAP -0.144963210468707 0.000354960857720622 NA NA NA hsa-miR-33a-3p SNAI2 0.20371038027126 0.212335697664505 1.57363779849313 5.91219248669788e-24 MirTarget -0.157829857169527 0.000355518332647255 NA NA NA hsa-miR-375 SNAI2 -4.24070205340868 7.48368361454041e-28 1.57363779849313 5.91219248669788e-24 miRanda -0.176728059166066 8.36927466430417e-27 NA NA NA hsa-miR-429 SNAI2 0.559451508722375 0.00563641638673083 1.57363779849313 5.91219248669788e-24 PITA;miRanda;miRNATAP -0.175312757486467 4.8083188190211e-07 NA NA NA hsa-miR-532-5p SNAI2 -0.021857649390892 0.830992272120134 1.57363779849313 5.91219248669788e-24 PITA -0.470416294863014 8.75387306864013e-12 NA NA NA hsa-miR-9-5p SNAI2 1.65694862043766 2.08325802567323e-05 1.57363779849313 5.91219248669788e-24 miRNAWalker2_validate -0.155442431965235 6.55014524540304e-19 NA NA NA hsa-miR-30e-5p SOX9 -1.02114836019762 6.81961221797866e-17 0.0683931238721325 0.737197692280025 MirTarget -0.242833569732096 0.000572264345895468 NA NA NA hsa-miR-33a-3p SOX9 0.20371038027126 0.212335697664505 0.0683931238721325 0.737197692280025 mirMAP -0.150035429758338 0.00661000448750032 NA NA NA hsa-miR-342-3p SOX9 0.99756868977753 9.28499866272332e-10 0.0683931238721325 0.737197692280025 miRanda -0.15088651656444 0.00489491553583666 NA NA NA hsa-miR-139-5p TGFB1 -1.46099200329485 7.85040381494472e-22 1.63261254184582 2.57292771878501e-37 miRanda -0.211396728970549 1.66114173348681e-08 NA NA NA hsa-miR-29b-3p TGFB1 -0.110721443686039 0.511264554091106 1.63261254184582 2.57292771878501e-37 miRTarBase -0.115557141630177 0.00118189427407973 NA NA NA hsa-miR-141-3p TGFB2 0.730011517758706 0.000120338355004032 0.0777328362726655 0.723018455166753 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.265467824704804 8.27771461885267e-08 NA NA NA hsa-miR-142-3p TGFB2 1.12754191614028 1.68798138028946e-08 0.0777328362726655 0.723018455166753 miRNATAP -0.16064296699396 0.000634225971259789 NA NA NA hsa-miR-149-5p TGFB2 0.443278770827687 0.0642022866136881 0.0777328362726655 0.723018455166753 MirTarget;miRNATAP -0.224915548613611 1.07874560543081e-08 NA NA NA hsa-miR-200a-3p TGFB2 0.607140814457753 0.00289840524858752 0.0777328362726655 0.723018455166753 MirTarget;miRNATAP -0.245845232906061 1.05145500844554e-07 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 0.0441399794719697 0.880456392176704 0.0777328362726655 0.723018455166753 MirTarget -0.213491686707761 2.34238525013733e-11 NA NA NA hsa-miR-29b-3p TGFB2 -0.110721443686039 0.511264554091106 0.0777328362726655 0.723018455166753 miRTarBase;MirTarget;miRNATAP -0.160451483561471 0.00470479835294533 NA NA NA hsa-miR-33a-3p TGFB2 0.20371038027126 0.212335697664505 0.0777328362726655 0.723018455166753 MirTarget;mirMAP -0.284781670411935 1.38897599512622e-06 NA NA NA hsa-miR-362-5p TGFB2 0.41089772861323 0.0404254902071382 0.0777328362726655 0.723018455166753 MirTarget -0.221176820672115 2.86666724884053e-06 NA NA NA hsa-miR-429 TGFB2 0.559451508722375 0.00563641638673083 0.0777328362726655 0.723018455166753 miRNATAP -0.213199102441814 5.30129859548984e-06 NA NA NA hsa-miR-454-3p TGFB2 1.54137391927201 4.15861570449376e-20 0.0777328362726655 0.723018455166753 MirTarget;miRNATAP -0.160741300174909 0.00334509150397591 NA NA NA hsa-miR-500a-5p TGFB2 0.675401699376111 8.24389004707854e-05 0.0777328362726655 0.723018455166753 mirMAP -0.159447320526312 0.00397529568273535 NA NA NA hsa-miR-500b-5p TGFB2 0.674875511637057 8.39602242688137e-05 0.0777328362726655 0.723018455166753 MirTarget -0.160233047874767 0.00378717200794635 NA NA NA hsa-miR-589-3p TGFB2 1.59559692667315 6.2886410639161e-15 0.0777328362726655 0.723018455166753 MirTarget -0.123357495887196 0.00914033095581057 NA NA NA hsa-miR-590-5p TGFB2 0.763025362395968 3.65305892505623e-09 0.0777328362726655 0.723018455166753 miRanda;miRNATAP -0.342026904103455 2.39104051032236e-06 NA NA NA hsa-miR-944 TGFB2 1.47323925060177 2.61626403984929e-13 0.0777328362726655 0.723018455166753 mirMAP -0.166241708180204 0.000315071117627543 NA NA NA hsa-miR-101-3p TGFBR1 -1.91263766544878 1.50270129259053e-39 0.615617809402788 1.98384557846381e-08 miRNAWalker2_validate;miRNATAP -0.137242751276775 7.52092687571314e-06 NA NA NA hsa-miR-101-5p TGFBR1 -1.429324744941 4.00032662184937e-18 0.615617809402788 1.98384557846381e-08 mirMAP -0.133177319619643 2.37858441571769e-06 NA NA NA hsa-miR-125b-5p TGFBR1 -0.993460109818276 5.07736727659894e-12 0.615617809402788 1.98384557846381e-08 miRNATAP -0.15777834540882 1.45852749097952e-06 NA NA NA hsa-miR-181c-5p TGFBR1 -0.168991199007857 0.196949106150297 0.615617809402788 1.98384557846381e-08 mirMAP;miRNATAP -0.10421464495814 0.0049760261835319 NA NA NA hsa-miR-200b-3p TGFBR1 0.0717138787925347 0.682858087587209 0.615617809402788 1.98384557846381e-08 mirMAP -0.197410832791802 2.77510960964195e-13 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-361-5p TGFBR1 0.0803683277369505 0.314043140368058 0.615617809402788 1.98384557846381e-08 miRanda;mirMAP;miRNATAP -0.161140636642561 0.00903876484470876 NA NA NA hsa-miR-374a-5p TGFBR1 -0.621903385111545 6.61791773205282e-12 0.615617809402788 1.98384557846381e-08 mirMAP -0.162078010547043 0.00217725764527797 NA NA NA hsa-miR-374b-5p TGFBR1 -0.288413933608091 0.0041474558664058 0.615617809402788 1.98384557846381e-08 mirMAP -0.207273863828956 1.67941177062955e-05 NA NA NA hsa-miR-429 TGFBR1 0.559451508722375 0.00563641638673083 0.615617809402788 1.98384557846381e-08 miRanda;miRNATAP -0.155570000352315 3.37635898013511e-11 NA NA NA hsa-miR-664a-3p TGFBR1 -0.256108763664991 0.0513188660751664 0.615617809402788 1.98384557846381e-08 mirMAP -0.200405898397308 4.18541096888924e-08 NA NA NA hsa-miR-15a-5p TGFBR3 0.783550182002274 2.60699595655907e-11 -2.33775701333658 1.4292781203639e-22 MirTarget;miRNATAP -0.649423432301841 3.84732333165554e-13 NA NA NA hsa-miR-15b-5p TGFBR3 0.85315666454713 3.79816274836297e-12 -2.33775701333658 1.4292781203639e-22 MirTarget;miRNATAP -0.262909121448377 0.00254854214224796 NA NA NA hsa-miR-16-2-3p TGFBR3 1.1567130855258 1.01867256952189e-14 -2.33775701333658 1.4292781203639e-22 mirMAP -0.392763412174948 2.2784891564096e-08 NA NA NA hsa-miR-16-5p TGFBR3 0.521122945828175 1.40561786410572e-06 -2.33775701333658 1.4292781203639e-22 MirTarget;miRNATAP -0.288490449441108 0.00412228400433026 NA NA NA hsa-miR-181a-5p TGFBR3 0.819060835827404 1.38616688310277e-13 -2.33775701333658 1.4292781203639e-22 miRNAWalker2_validate;mirMAP;miRNATAP -0.481161973455912 5.13177365519917e-07 NA NA NA hsa-miR-181b-5p TGFBR3 0.974255518824355 2.64876280203475e-16 -2.33775701333658 1.4292781203639e-22 mirMAP -0.650006419850336 9.47730765634074e-14 NA NA NA hsa-miR-186-5p TGFBR3 0.353452958261612 0.000145058448579496 -2.33775701333658 1.4292781203639e-22 MirTarget -0.461626791003898 8.32887014485828e-05 NA NA NA hsa-miR-18a-3p TGFBR3 1.82583720936229 7.51297960972179e-19 -2.33775701333658 1.4292781203639e-22 MirTarget -0.316260423974977 9.38562501878288e-10 NA NA NA hsa-miR-18a-5p TGFBR3 1.65455873230328 3.76457892277775e-20 -2.33775701333658 1.4292781203639e-22 MirTarget -0.43252036938629 2.91936769758989e-14 NA NA NA hsa-miR-193a-3p TGFBR3 0.22120710726779 0.111827069464729 -2.33775701333658 1.4292781203639e-22 MirTarget;miRanda;miRNATAP -0.559948272931618 3.23084375018462e-13 NA NA NA hsa-miR-193b-3p TGFBR3 1.72788400801602 3.0722151264559e-21 -2.33775701333658 1.4292781203639e-22 miRNAWalker2_validate;MirTarget;miRNATAP -0.624709682577051 5.6021228518868e-31 NA NA NA hsa-miR-21-5p TGFBR3 1.62465922021121 3.44191300985109e-58 -2.33775701333658 1.4292781203639e-22 miRNAWalker2_validate -1.04907878363987 1.11926077262689e-30 NA NA NA hsa-miR-27a-3p TGFBR3 0.348456440505425 0.00126682892514312 -2.33775701333658 1.4292781203639e-22 MirTarget;miRNATAP -0.271051865314538 0.00737876652969619 NA NA NA hsa-miR-29a-5p TGFBR3 0.323252792625584 0.0370417231222825 -2.33775701333658 1.4292781203639e-22 mirMAP -0.28088701682147 6.08590951389061e-05 NA NA NA hsa-miR-339-5p TGFBR3 1.07771430326938 2.45772601859307e-09 -2.33775701333658 1.4292781203639e-22 miRanda -0.310476677751781 1.29050976642217e-07 NA NA NA hsa-miR-3607-3p TGFBR3 1.01377165357363 9.13355519701165e-05 -2.33775701333658 1.4292781203639e-22 mirMAP -0.150048488640653 0.00031564641483518 NA NA NA hsa-miR-424-5p TGFBR3 1.48125289532143 9.10372985713165e-19 -2.33775701333658 1.4292781203639e-22 MirTarget;miRNATAP -0.472557458706331 1.28030826322785e-14 NA NA NA hsa-miR-450b-5p TGFBR3 1.25529820885833 1.18847120528666e-15 -2.33775701333658 1.4292781203639e-22 mirMAP -0.400335621740456 1.92870135526974e-09 NA NA NA hsa-miR-455-5p TGFBR3 1.408595672323 5.52039116456697e-22 -2.33775701333658 1.4292781203639e-22 miRanda -0.817784013693157 3.0691058383061e-34 NA NA NA hsa-miR-484 TGFBR3 0.918280909791707 1.39168306854263e-14 -2.33775701333658 1.4292781203639e-22 MirTarget;miRNATAP -0.246338322872403 0.00584052894071287 NA NA NA hsa-miR-589-3p TGFBR3 1.59559692667315 6.2886410639161e-15 -2.33775701333658 1.4292781203639e-22 MirTarget -0.311842535860169 4.80435029808815e-09 NA NA NA hsa-miR-590-5p TGFBR3 0.763025362395968 3.65305892505623e-09 -2.33775701333658 1.4292781203639e-22 miRanda -0.431850003764857 1.65091443898854e-07 NA NA NA hsa-miR-7-1-3p TGFBR3 1.13646121619622 1.49823237535933e-14 -2.33775701333658 1.4292781203639e-22 mirMAP -0.281127891464509 8.70035498981649e-05 NA NA NA hsa-miR-944 TGFBR3 1.47323925060177 2.61626403984929e-13 -2.33775701333658 1.4292781203639e-22 mirMAP -0.190248797037249 0.000300434783380661 NA NA NA hsa-let-7b-5p TRIM28 -0.2489842756826 0.0211384499461719 0.471952931099384 5.24746847325565e-10 miRNAWalker2_validate -0.139538661486328 7.11048643956679e-06 NA NA NA hsa-miR-320b WNT11 1.23473838180754 3.04337566045537e-14 -0.224750666322645 0.510626012221646 miRanda -0.270316259616059 0.0024603931714496 NA NA NA hsa-miR-429 WNT11 0.559451508722375 0.00563641638673083 -0.224750666322645 0.510626012221646 miRNATAP -0.209942515620557 0.00424611523018706 NA NA NA hsa-miR-590-3p WNT11 0.221436901462551 0.0965904764063157 -0.224750666322645 0.510626012221646 miRanda -0.501468167000306 6.77947598913954e-06 NA NA NA hsa-miR-107 WNT4 -0.0447040564279497 0.671618791096755 0.155343533272991 0.546942165628682 PITA;miRNATAP -0.442918090382549 3.50237250623185e-05 NA NA NA hsa-let-7a-3p WNT5A 0.0966652362351867 0.423761916840503 0.230244489186426 0.276036125068596 miRNATAP -0.236393902681147 0.00203160512009966 NA NA NA hsa-miR-142-3p WNT5A 1.12754191614028 1.68798138028946e-08 0.230244489186426 0.276036125068596 miRanda -0.170207296882227 0.000170819602841971 NA NA NA hsa-miR-155-5p WNT5A 0.533437622040649 0.00248671179205372 0.230244489186426 0.276036125068596 miRNAWalker2_validate;mirMAP -0.292461135450501 1.33940668925285e-08 NA NA NA hsa-miR-15b-3p WNT5A 1.05020782493504 6.38723677324836e-14 0.230244489186426 0.276036125068596 mirMAP -0.175165295991482 0.00645298447676834 NA NA NA hsa-miR-16-2-3p WNT5A 1.1567130855258 1.01867256952189e-14 0.230244489186426 0.276036125068596 MirTarget;mirMAP -0.335972431523505 1.53488293667871e-08 NA NA NA hsa-miR-16-5p WNT5A 0.521122945828175 1.40561786410572e-06 0.230244489186426 0.276036125068596 miRNAWalker2_validate -0.370382454158463 1.19067012660461e-05 NA NA NA hsa-miR-186-5p WNT5A 0.353452958261612 0.000145058448579496 0.230244489186426 0.276036125068596 miRNAWalker2_validate;mirMAP;miRNATAP -0.450879801993129 5.17906690047651e-06 NA NA NA hsa-miR-205-3p WNT5A 1.2960640797621 5.80786479909147e-11 0.230244489186426 0.276036125068596 mirMAP -0.146584017158563 0.00129989170721468 NA NA NA hsa-miR-26b-5p WNT5A -0.254478038884324 0.0285227763044636 0.230244489186426 0.276036125068596 mirMAP;miRNATAP -0.280915259189257 0.00040737667148347 NA NA NA hsa-miR-29a-5p WNT5A 0.323252792625584 0.0370417231222825 0.230244489186426 0.276036125068596 mirMAP -0.260976602260308 1.01644561078111e-05 NA NA NA hsa-miR-30a-3p WNT5A -2.26144364746452 8.12421214153823e-31 0.230244489186426 0.276036125068596 mirMAP -0.118105642486288 0.00756898976025631 NA NA NA hsa-miR-30a-5p WNT5A -1.79779915425811 1.93360169837799e-26 0.230244489186426 0.276036125068596 miRNAWalker2_validate;mirMAP -0.17873480778717 0.000544504752065439 NA NA NA hsa-miR-30b-5p WNT5A -0.400238605368173 0.00346540992719245 0.230244489186426 0.276036125068596 mirMAP -0.382501092288541 8.72466565087115e-09 NA NA NA hsa-miR-30c-5p WNT5A 0.021222006155897 0.886366656528128 0.230244489186426 0.276036125068596 mirMAP -0.315278604382802 3.20061386526904e-07 NA NA NA hsa-miR-30d-3p WNT5A -0.577371911152798 2.02950840095287e-06 0.230244489186426 0.276036125068596 mirMAP -0.330966437618027 1.06807407622655e-05 NA NA NA hsa-miR-30e-3p WNT5A -0.890635378639789 1.65740480611339e-16 0.230244489186426 0.276036125068596 mirMAP -0.32558124534923 8.6493574536442e-05 NA NA NA hsa-miR-30e-5p WNT5A -1.02114836019762 6.81961221797866e-17 0.230244489186426 0.276036125068596 mirMAP -0.302477702909968 3.39614513198558e-05 NA NA NA hsa-miR-330-5p WNT5A 0.944693925383906 5.04972895657346e-13 0.230244489186426 0.276036125068596 miRanda -0.29230342849594 2.09572746719721e-05 NA NA NA hsa-miR-374b-5p WNT5A -0.288413933608091 0.0041474558664058 0.230244489186426 0.276036125068596 MirTarget;miRNATAP -0.304076813996518 0.000947733080358778 NA NA NA hsa-miR-576-5p WNT5A 0.940432050128373 6.90227595663302e-12 0.230244489186426 0.276036125068596 mirMAP -0.285474332440034 1.36168151290682e-05 NA NA NA hsa-miR-582-5p WNT5A -0.0366995972742474 0.821827119138923 0.230244489186426 0.276036125068596 miRNATAP -0.165827000654824 0.00340576037437022 NA NA NA hsa-miR-590-3p WNT5A 0.221436901462551 0.0965904764063157 0.230244489186426 0.276036125068596 miRanda;mirMAP;miRNATAP -0.250968399301464 0.000285345561598827 NA NA NA hsa-miR-7-1-3p WNT5A 1.13646121619622 1.49823237535933e-14 0.230244489186426 0.276036125068596 mirMAP -0.288658318926048 1.72502648080357e-06 NA NA NA hsa-miR-92a-3p WNT5A 0.994679542307232 1.32587679156217e-16 0.230244489186426 0.276036125068596 miRNAWalker2_validate -0.244964920046973 0.00100835732123874 NA NA NA