miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-18a-5p ABR 2.29585803678176 4.13931899001596e-14 -0.312559475376877 0.602777794967167 miRNAWalker2_validate;mirMAP -0.109068853724789 3.43667008155402e-21 NA NA NA hsa-miR-18a-5p ADAMTS2 2.29585803678176 4.13931899001596e-14 -0.286300677747046 0.511667136335646 mirMAP -0.151270479965282 2.23092352991542e-06 NA NA NA hsa-miR-18a-5p AFF4 2.29585803678176 4.13931899001596e-14 -0.703872124755367 0.275601125831837 miRNAWalker2_validate -0.216780642407195 5.47601743907678e-38 NA NA NA hsa-miR-18a-5p ALCAM 2.29585803678176 4.13931899001596e-14 -1.44213442376849 0.0323015123311927 MirTarget;miRNATAP -0.342138218282154 4.63746773220129e-31 NA NA NA hsa-miR-18a-5p ANKRD50 2.29585803678176 4.13931899001596e-14 -0.731171419106681 0.176754074331243 MirTarget;miRNATAP -0.177741763059093 2.01514957148336e-16 NA NA NA hsa-miR-18a-5p APOLD1 2.29585803678176 4.13931899001596e-14 -0.376335247268241 0.452099926727468 mirMAP -0.158264613633656 3.21161314972337e-09 NA NA NA hsa-miR-18a-5p ARFGEF2 2.29585803678176 4.13931899001596e-14 -0.403974847064543 0.505750315604732 MirTarget -0.121111361663676 9.26771791125924e-12 NA NA NA hsa-miR-18a-5p ARHGAP5 2.29585803678176 4.13931899001596e-14 -0.0467432865023145 0.9351284594763 MirTarget -0.116582874797694 7.2816059600348e-10 NA NA NA hsa-miR-18a-5p ARL15 2.29585803678176 4.13931899001596e-14 -0.824504347980591 0.0221666285037991 MirTarget;miRNATAP -0.256659599347071 8.53689264458731e-32 NA NA NA hsa-miR-18a-5p ASTN1 2.29585803678176 4.13931899001596e-14 0.108687925237062 0.731194094181716 MirTarget -0.24658682628591 3.80944772672986e-06 NA NA NA hsa-miR-18a-5p ASXL2 2.29585803678176 4.13931899001596e-14 -0.0411968235596731 0.92195617364372 miRNATAP -0.172959671290264 8.68420972604786e-09 NA NA NA hsa-miR-18a-5p ATF7 2.29585803678176 4.13931899001596e-14 -0.314214952901342 0.577417375663342 mirMAP -0.135353522649776 2.5614664515906e-27 NA NA NA hsa-miR-18a-5p ATM 2.29585803678176 4.13931899001596e-14 -0.0493046365018301 0.923235059785624 miRNAWalker2_validate;miRTarBase;MirTarget -0.116309277677122 3.16867464269194e-11 23857602;23437304;25963391;23229340 Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression breast cancer;colorectal cancer;cervical and endocervical cancer;colon cancer hsa-miR-18a-5p ATP1B2 2.29585803678176 4.13931899001596e-14 -0.534070926473392 0.0104546738251564 mirMAP -0.227686734467817 6.54947879295752e-15 NA NA NA hsa-miR-18a-5p ATP2B1 2.29585803678176 4.13931899001596e-14 -0.318945553342942 0.543396240454942 miRNATAP -0.120983732791358 3.71397545202766e-12 NA NA NA hsa-miR-18a-5p ATP2C2 2.29585803678176 4.13931899001596e-14 -0.98892887747084 0.0117017545691764 MirTarget -0.198572649927767 5.57829579300383e-07 NA NA NA hsa-miR-18a-5p ATXN1 2.29585803678176 4.13931899001596e-14 -0.476138919679846 0.351257844473467 MirTarget;miRNATAP -0.158757938966941 9.08602732129693e-23 NA NA NA hsa-miR-18a-5p BBX 2.29585803678176 4.13931899001596e-14 -0.0588524416015161 0.916540577808447 MirTarget;miRNATAP -0.107164441129034 1.56844778188935e-10 NA NA NA hsa-miR-18a-5p BHLHE22 2.29585803678176 4.13931899001596e-14 0.389932241284234 0.0480957043662163 MirTarget;miRNATAP -0.102847395049489 0.00101179851804635 NA NA NA hsa-miR-18a-5p C1orf21 2.29585803678176 4.13931899001596e-14 -1.3116600895155 0.037633805532108 mirMAP -0.352380566715628 9.90850405457288e-39 NA NA NA hsa-miR-18a-5p C1orf226 2.29585803678176 4.13931899001596e-14 -0.83799892619079 0.0862808022528832 mirMAP -0.288803056276439 1.14096045122522e-18 NA NA NA hsa-miR-18a-5p C5orf30 2.29585803678176 4.13931899001596e-14 -1.63731454024135 0.00035285241846172 miRNATAP -0.221817652321724 1.71205775534449e-21 NA NA NA hsa-miR-18a-5p CA12 2.29585803678176 4.13931899001596e-14 -4.60824015441829 2.67223288642364e-10 miRNAWalker2_validate;MirTarget -0.845217777323844 1.2280252750954e-70 NA NA NA hsa-miR-18a-5p CACNG4 2.29585803678176 4.13931899001596e-14 -3.35808733108355 1.01411652848366e-09 mirMAP -0.479660977852052 1.65065818706956e-15 NA NA NA hsa-miR-18a-5p CALN1 2.29585803678176 4.13931899001596e-14 -1.13844791757 0.00177546409753963 mirMAP -0.423327540543552 1.61797555803963e-16 NA NA NA hsa-miR-18a-5p CAMK2B 2.29585803678176 4.13931899001596e-14 -1.555594885724 1.35370226826514e-06 mirMAP -0.272652665944852 5.85107409807785e-08 NA NA NA hsa-miR-18a-5p CAMK2N1 2.29585803678176 4.13931899001596e-14 -1.68564190240764 0.00250869030556964 miRNATAP -0.297143132124591 5.13523150174157e-24 NA NA NA hsa-miR-18a-5p CASZ1 2.29585803678176 4.13931899001596e-14 -0.876955493153372 0.0913968455267192 mirMAP -0.224148052389293 1.08753977757912e-28 NA NA NA hsa-miR-18a-5p CDON 2.29585803678176 4.13931899001596e-14 -0.932755250435235 0.0370096386136306 mirMAP -0.269832410713206 2.46101550483186e-23 NA NA NA hsa-miR-18a-5p CLASP2 2.29585803678176 4.13931899001596e-14 -0.437673296089148 0.395811350601931 miRNATAP -0.144015352857882 3.91095997033606e-25 NA NA NA hsa-miR-18a-5p CREBL2 2.29585803678176 4.13931899001596e-14 -0.549328377929987 0.345694685390556 miRNAWalker2_validate;MirTarget;miRNATAP -0.18688020696653 6.39009893275456e-46 NA NA NA hsa-miR-18a-5p CRIM1 2.29585803678176 4.13931899001596e-14 -0.30852804166978 0.634297036399116 MirTarget;miRNATAP -0.268538776483512 4.74205100277358e-24 NA NA NA hsa-miR-18a-5p CSNK1G1 2.29585803678176 4.13931899001596e-14 -0.461828350171912 0.313055865644168 mirMAP -0.107632067902284 2.58794384497738e-15 NA NA NA hsa-miR-18a-5p CSRNP3 2.29585803678176 4.13931899001596e-14 -0.299105566944235 0.371187975460312 miRNAWalker2_validate;miRNATAP -0.362405771137282 3.19672029425217e-15 NA NA NA hsa-miR-18a-5p CTDSPL 2.29585803678176 4.13931899001596e-14 -0.406212474550546 0.460806418428077 miRNAWalker2_validate;MirTarget;miRNATAP -0.158588848975107 3.51928970904997e-32 NA NA NA hsa-miR-18a-5p CTGF 2.29585803678176 4.13931899001596e-14 -0.215367037595757 0.781176358373922 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.119846814285957 2.0448230920207e-05 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-18a-5p CYP4F11 2.29585803678176 4.13931899001596e-14 -2.83072267551312 1.17177976552715e-13 MirTarget -0.608616466590783 3.56154348444121e-22 NA NA NA hsa-miR-18a-5p DAAM2 2.29585803678176 4.13931899001596e-14 -0.0402745144958083 0.924877679800936 miRNAWalker2_validate -0.128936539387179 3.13505694340858e-06 NA NA NA hsa-miR-18a-5p DCUN1D3 2.29585803678176 4.13931899001596e-14 -0.211621277631069 0.504175374129795 miRNAWalker2_validate -0.11981287755687 3.22327193832774e-17 NA NA NA hsa-miR-18a-5p DICER1 2.29585803678176 4.13931899001596e-14 -0.296736937053201 0.609130672882289 miRNAWalker2_validate -0.136912050395007 2.01038095738162e-17 27338043;21935572 MiR 18a upregulation decreases Dicer expression and confers paclitaxel resistance in triple negative breast cancer; In this study we investigated the association among miR-18a dysregulation Dicer dysregulation and paclitaxel PTX resistance in TNBC cells; The influence of miR-18a overexpression on Dicer expression was measured by qRT-PCR and Western blot analysis; MiR-18a overexpression directly led to Dicer repression at mRNA and protein level; This study found that miR-18a is an important miRNA that suppresses Dicer expression and increases PTX resistance in TNBC cells;microRNA 18a a member of the oncogenic miR 17 92 cluster targets Dicer and suppresses cell proliferation in bladder cancer T24 cells; Furthermore ectopic expression of miR-18a in T24 cells down-regulated Dicer expression at both the mRNA and protein level while inhibition miR-18a by antisense oligonucleotides could enhance Dicer expression in T24 cells; Two binding sites of miR-18a were found in Dicer 3' untranslated region 3' UTR; In addition knockdown of Dicer expression by siRNA mimicked cell growth suppression induced by miR-18a in T24 cells; These results show that miR-18a functions as a tumor suppressor by targeting Dicer in bladder cancer T24 cells and revealed a noteworthy feedback loop which may be utilized by the miR-17-92 cluster to control miRNA output and prevent its overexpression drug resistance; breast cancer;bladder cancer hsa-miR-18a-5p DNAJC16 2.29585803678176 4.13931899001596e-14 -0.572916068567619 0.217738123971803 MirTarget -0.154106968328649 2.07514991406951e-34 NA NA NA hsa-miR-18a-5p DOCK4 2.29585803678176 4.13931899001596e-14 0.0682252033258575 0.864672472175758 MirTarget -0.105041741749793 1.36108409679642e-07 NA NA NA hsa-miR-18a-5p DPY19L3 2.29585803678176 4.13931899001596e-14 -0.541752254913416 0.157107066790334 MirTarget -0.1842473421487 2.56869719979074e-14 NA NA NA hsa-miR-18a-5p DST 2.29585803678176 4.13931899001596e-14 0.0159871038958519 0.982364261487702 mirMAP -0.253594711302634 1.70338130586849e-17 NA NA NA hsa-miR-18a-5p ESR1 2.29585803678176 4.13931899001596e-14 -6.14976130956365 3.35739499466122e-17 miRNAWalker2_validate;miRTarBase;miRNATAP -1.14044745041939 3.5647791599912e-74 19027010;24975878 MicroRNA 18a prevents estrogen receptor alpha expression promoting proliferation of hepatocellular carcinoma cells; The gene ESR1 which encodes the estrogen receptor-alpha ERalpha was identified as a target of miR-18a miR-18a can repress ERalpha translation by binding to its mRNA at the 3' untranslated region;Elevated p53 promotes the processing of miR 18a to decrease estrogen receptor α in female hepatocellular carcinoma; Our previous study identified that estrogen receptor alpha ERα protein is downregulated in 60% of female HCC cases via a miR-18a elevation mediated suppression of ERα translation ; liver cancer;liver cancer hsa-miR-18a-5p F3 2.29585803678176 4.13931899001596e-14 -0.0691739539487113 0.882405693197857 MirTarget -0.22259238842336 5.95650101731875e-11 NA NA NA hsa-miR-18a-5p FAIM2 2.29585803678176 4.13931899001596e-14 -1.17062084953123 0.000198308538540209 mirMAP -0.36753895081149 1.06119137499698e-14 NA NA NA hsa-miR-18a-5p FAM166B 2.29585803678176 4.13931899001596e-14 -0.211517423149237 0.426848124792193 MirTarget -0.142348737056905 0.00112263071949073 NA NA NA hsa-miR-18a-5p FAM168A 2.29585803678176 4.13931899001596e-14 -0.0384355950528392 0.90735006894712 mirMAP -0.123229308838653 5.4509195026933e-07 NA NA NA hsa-miR-18a-5p FAM196A 2.29585803678176 4.13931899001596e-14 -2.85680700789912 4.07793226917642e-15 MirTarget -0.558344683915752 1.52927869844399e-19 NA NA NA hsa-miR-18a-5p FBP1 2.29585803678176 4.13931899001596e-14 -2.60007311712345 3.66468362738828e-06 MirTarget -0.497445174576123 3.83311300421063e-49 NA NA NA hsa-miR-18a-5p FEM1C 2.29585803678176 4.13931899001596e-14 -0.617439719156987 0.209541192993277 miRNAWalker2_validate -0.173013762406906 5.3483165847e-34 NA NA NA hsa-miR-18a-5p FGF1 2.29585803678176 4.13931899001596e-14 -0.646653213999114 0.101194218943267 MirTarget -0.308725947141596 9.70167258927243e-25 NA NA NA hsa-miR-18a-5p FNDC3A 2.29585803678176 4.13931899001596e-14 -0.246631153777665 0.65711714792856 miRNATAP -0.147319318642176 4.56307201490207e-21 NA NA NA hsa-miR-18a-5p FRS2 2.29585803678176 4.13931899001596e-14 -1.13069960626707 0.030767637694059 MirTarget -0.257900743959529 2.45547348306966e-34 NA NA NA hsa-miR-18a-5p FRYL 2.29585803678176 4.13931899001596e-14 -0.451537144620408 0.402771813048913 miRNATAP -0.14842902721644 1.40370457600511e-20 NA NA NA hsa-miR-18a-5p GAB1 2.29585803678176 4.13931899001596e-14 -0.508952389031208 0.286258106886842 MirTarget;miRNATAP -0.178021538614324 3.83791153370437e-26 NA NA NA hsa-miR-18a-5p GAS7 2.29585803678176 4.13931899001596e-14 -0.450207653056991 0.393461285145045 mirMAP -0.257144385360811 3.25646718719617e-23 NA NA NA hsa-miR-18a-5p GLRB 2.29585803678176 4.13931899001596e-14 -1.38207703608463 4.47914851334142e-05 MirTarget;miRNATAP -0.420712583557575 2.92416921018491e-29 NA NA NA hsa-miR-18a-5p GNA11 2.29585803678176 4.13931899001596e-14 -0.187328717972722 0.667674171638139 MirTarget -0.131470047953861 4.21510730519923e-13 NA NA NA hsa-miR-18a-5p GNG7 2.29585803678176 4.13931899001596e-14 0.317962955990684 0.398489534323842 mirMAP -0.102334215711126 0.000163584996294418 NA NA NA hsa-miR-18a-5p GNPDA2 2.29585803678176 4.13931899001596e-14 -0.441401700771515 0.247543071258649 MirTarget -0.137411618557432 2.11305820150809e-19 NA NA NA hsa-miR-18a-5p GTF2A1 2.29585803678176 4.13931899001596e-14 -0.309679596591037 0.277386744834285 MirTarget -0.208023597477171 5.11466996053174e-11 NA NA NA hsa-miR-18a-5p H6PD 2.29585803678176 4.13931899001596e-14 -0.0355109230194541 0.955452895307496 mirMAP -0.126944181339438 8.99389486725863e-20 NA NA NA hsa-miR-18a-5p HERC1 2.29585803678176 4.13931899001596e-14 -0.30554347317482 0.599547039669648 miRNAWalker2_validate -0.166678978204255 1.41603516627385e-25 NA NA NA hsa-miR-18a-5p HIPK2 2.29585803678176 4.13931899001596e-14 -0.0377895294478385 0.950573759425897 mirMAP -0.116154083309191 4.06313103703854e-06 NA NA NA hsa-miR-18a-5p HLF 2.29585803678176 4.13931899001596e-14 0.192061018115972 0.614775006708452 MirTarget -0.226586768681528 6.54880708946071e-07 NA NA NA hsa-miR-18a-5p HMBOX1 2.29585803678176 4.13931899001596e-14 -0.244394364705621 0.305843992773066 MirTarget;miRNATAP -0.21100115910716 2.13179784211135e-22 NA NA NA hsa-miR-18a-5p HOXA9 2.29585803678176 4.13931899001596e-14 0.298313721458941 0.24004537666198 miRNAWalker2_validate -0.190067368057164 5.3489040580045e-07 NA NA NA hsa-miR-18a-5p IGFBP5 2.29585803678176 4.13931899001596e-14 -1.22351036476979 0.164375209536685 mirMAP -0.225414876847806 1.60030082423832e-09 NA NA NA hsa-miR-18a-5p IL17B 2.29585803678176 4.13931899001596e-14 0.045152720010412 0.894455044253153 MirTarget -0.280256674044975 5.69689446160658e-07 NA NA NA hsa-miR-18a-5p ITGA2 2.29585803678176 4.13931899001596e-14 -0.675598414227917 0.174926410785877 MirTarget -0.277288585922338 1.4587093955565e-19 NA NA NA hsa-miR-18a-5p KCNA1 2.29585803678176 4.13931899001596e-14 -0.285937679368812 0.400718947761983 MirTarget;miRNATAP -0.365812218557213 2.64695980468239e-12 NA NA NA hsa-miR-18a-5p KIF13B 2.29585803678176 4.13931899001596e-14 -1.25873176082656 0.033200486960211 mirMAP -0.42694013307171 4.05713490942489e-69 NA NA NA hsa-miR-18a-5p LONP2 2.29585803678176 4.13931899001596e-14 -0.572293949051525 0.320540277276559 mirMAP -0.13034580866847 6.3129851607025e-14 NA NA NA hsa-miR-18a-5p LONRF2 2.29585803678176 4.13931899001596e-14 -3.45738858653069 1.11871959084766e-13 mirMAP -0.656490113300794 9.01275306546033e-40 NA NA NA hsa-miR-18a-5p LPP 2.29585803678176 4.13931899001596e-14 0.0599000979079998 0.881653412887322 mirMAP -0.200432677688042 1.54370427595509e-14 NA NA NA hsa-miR-18a-5p LRP10 2.29585803678176 4.13931899001596e-14 -0.636168125677097 0.378249726866834 mirMAP -0.193626966923308 2.71454814841761e-55 NA NA NA hsa-miR-18a-5p MAN2B2 2.29585803678176 4.13931899001596e-14 -0.807991584039159 0.166308029102152 mirMAP -0.203760849703937 1.573557107246e-51 NA NA NA hsa-miR-18a-5p MAP3K1 2.29585803678176 4.13931899001596e-14 -1.01322313132264 0.0792800255031362 miRNATAP -0.316610440339497 2.14317799336319e-46 NA NA NA hsa-miR-18a-5p MDGA1 2.29585803678176 4.13931899001596e-14 -0.831308540027255 0.0041539322111643 miRNATAP -0.200479649226778 5.41840066449566e-14 NA NA NA hsa-miR-18a-5p MEF2C 2.29585803678176 4.13931899001596e-14 0.0448929221885477 0.9223949985253 MirTarget -0.127566112747227 1.28918194375564e-10 NA NA NA hsa-miR-18a-5p MEF2D 2.29585803678176 4.13931899001596e-14 -0.479136295251636 0.433050709736428 miRNATAP -0.13204707652659 2.29150705324917e-30 NA NA NA hsa-miR-18a-5p MPPED2 2.29585803678176 4.13931899001596e-14 -0.687187817124928 0.00900743840652314 mirMAP -0.210280450250362 7.08623181228274e-08 NA NA NA hsa-miR-18a-5p MTHFR 2.29585803678176 4.13931899001596e-14 -0.497025274176287 0.299164152456536 mirMAP -0.1679667982994 4.02543773165036e-24 NA NA NA hsa-miR-18a-5p NBEA 2.29585803678176 4.13931899001596e-14 -1.96176842607598 1.57470607601836e-07 miRNAWalker2_validate -0.528982821660413 7.82609567879678e-60 NA NA NA hsa-miR-18a-5p NCOA1 2.29585803678176 4.13931899001596e-14 -0.108333665090036 0.848773517382568 MirTarget;miRNATAP -0.134970373152042 9.83382622027132e-23 NA NA NA hsa-miR-18a-5p NEDD4 2.29585803678176 4.13931899001596e-14 -0.566155797285099 0.164921384788646 MirTarget;miRNATAP -0.237772989643153 1.33736803467272e-37 NA NA NA hsa-miR-18a-5p NEDD9 2.29585803678176 4.13931899001596e-14 -0.0175351186790067 0.97525292400164 miRTarBase;MirTarget;miRNATAP -0.200054503528031 5.0385866880316e-15 22308110 NEDD9 and CDK19 were identified as novel miR-18a targets and were shown to be pro-proliferative genes with RNA interference of their transcripts decreasing proliferation in CRC cells colorectal cancer hsa-miR-18a-5p NHLRC2 2.29585803678176 4.13931899001596e-14 -0.31260188517604 0.236452791785795 mirMAP -0.160538006387603 2.85525253960548e-12 NA NA NA hsa-miR-18a-5p NR3C1 2.29585803678176 4.13931899001596e-14 -0.0422673261543753 0.939324296532065 miRNAWalker2_validate;miRTarBase;miRNATAP -0.16520939885116 1.39190676142027e-13 NA NA NA hsa-miR-18a-5p NRG1 2.29585803678176 4.13931899001596e-14 0.350226527230034 0.259630594465776 miRNATAP -0.243721864987581 3.32805830007628e-06 NA NA NA hsa-miR-18a-5p NTRK3 2.29585803678176 4.13931899001596e-14 0.647062771111165 0.0605869384885256 mirMAP -0.221782427020024 6.64375802513301e-05 NA NA NA hsa-miR-18a-5p OLFML2A 2.29585803678176 4.13931899001596e-14 -0.696270187514949 0.184675319316509 mirMAP -0.195371289535398 5.30593895273794e-22 NA NA NA hsa-miR-18a-5p ORAI3 2.29585803678176 4.13931899001596e-14 -0.924063958047162 0.0459152532310562 miRNAWalker2_validate;miRNATAP -0.17646569687491 1.83610431856552e-27 NA NA NA hsa-miR-18a-5p PAPPA 2.29585803678176 4.13931899001596e-14 0.00105330256293978 0.996408656929165 miRNATAP -0.131810384950291 1.17242589142028e-05 NA NA NA hsa-miR-18a-5p PARD6B 2.29585803678176 4.13931899001596e-14 -1.86380518224737 1.73020124710611e-05 miRNAWalker2_validate;MirTarget -0.284811022335125 1.39901909644042e-14 NA NA NA hsa-miR-18a-5p PCBD2 2.29585803678176 4.13931899001596e-14 -0.841375605337066 0.0314846497560824 mirMAP -0.147378285611701 7.88716172628899e-25 NA NA NA hsa-miR-18a-5p PCDHGA10 2.29585803678176 4.13931899001596e-14 -1.02599338770521 0.000229629541107102 mirMAP -0.242139355042132 1.00366706189103e-08 NA NA NA hsa-miR-18a-5p PCDHGA12 2.29585803678176 4.13931899001596e-14 -0.614791287888589 0.00801632766631189 mirMAP -0.232968463381782 7.18619587742436e-11 NA NA NA hsa-miR-18a-5p PCDHGA2 2.29585803678176 4.13931899001596e-14 -0.366883725657329 0.163611348779999 mirMAP -0.393699736732539 2.07049087605291e-20 NA NA NA hsa-miR-18a-5p PCDHGA3 2.29585803678176 4.13931899001596e-14 -0.375384995335331 0.0860587312531214 mirMAP -0.310939315331092 5.85295983356843e-18 NA NA NA hsa-miR-18a-5p PCDHGA4 2.29585803678176 4.13931899001596e-14 -0.491944025223461 0.0446640271103477 mirMAP -0.270711505047657 2.8894474513565e-11 NA NA NA hsa-miR-18a-5p PCDHGA5 2.29585803678176 4.13931899001596e-14 -0.504232992352929 0.0356690469940882 mirMAP -0.331952352035761 7.19409680481861e-17 NA NA NA hsa-miR-18a-5p PCDHGA6 2.29585803678176 4.13931899001596e-14 -0.306181887310045 0.131637428477699 mirMAP -0.2355442960291 1.71995216927291e-12 NA NA NA hsa-miR-18a-5p PCDHGA7 2.29585803678176 4.13931899001596e-14 -0.510368658074136 0.0254377527770089 mirMAP -0.246415074762893 1.09196217715879e-10 NA NA NA hsa-miR-18a-5p PCDHGA9 2.29585803678176 4.13931899001596e-14 -0.929058857476342 7.3287059629956e-05 mirMAP -0.371763758709927 4.79180816588326e-23 NA NA NA hsa-miR-18a-5p PCDHGB2 2.29585803678176 4.13931899001596e-14 0.0162486274221858 0.947633795296214 mirMAP -0.189902126044122 3.49203348705015e-06 NA NA NA hsa-miR-18a-5p PCDHGB3 2.29585803678176 4.13931899001596e-14 0.460816760938844 0.0691447041864256 mirMAP -0.131766555226161 0.000652098635404244 NA NA NA hsa-miR-18a-5p PCDHGB4 2.29585803678176 4.13931899001596e-14 -0.258895150993977 0.340712444958824 mirMAP -0.211671953766436 3.24984970679208e-06 NA NA NA hsa-miR-18a-5p PCDHGB6 2.29585803678176 4.13931899001596e-14 -0.608780972134696 0.00833025630621595 mirMAP -0.314370946614473 1.55748090909347e-19 NA NA NA hsa-miR-18a-5p PCDHGB7 2.29585803678176 4.13931899001596e-14 -0.93034539306053 0.00210967095174942 mirMAP -0.418220524698778 3.98944932120566e-29 NA NA NA hsa-miR-18a-5p PCDHGC5 2.29585803678176 4.13931899001596e-14 0.237423039813538 0.396043617746842 mirMAP -0.110642905783501 0.00411137141632271 NA NA NA hsa-miR-18a-5p PDE4A 2.29585803678176 4.13931899001596e-14 -0.745039604799809 0.0849222677024282 mirMAP -0.219492173758275 5.10863328798831e-20 NA NA NA hsa-miR-18a-5p PDE5A 2.29585803678176 4.13931899001596e-14 -0.615016630060292 0.154056136101874 MirTarget -0.242971636442388 1.60889514256819e-14 NA NA NA hsa-miR-18a-5p PHC3 2.29585803678176 4.13931899001596e-14 -0.309485945461203 0.574880189509787 MirTarget -0.139881081162043 2.42586368229585e-23 NA NA NA hsa-miR-18a-5p PRDM2 2.29585803678176 4.13931899001596e-14 -0.228035601894347 0.674831075008547 mirMAP -0.135945572227408 1.74400245048004e-28 NA NA NA hsa-miR-18a-5p PRICKLE2 2.29585803678176 4.13931899001596e-14 -1.20320410751354 0.0117589308024567 MirTarget -0.387730469036141 3.85619154280423e-61 NA NA NA hsa-miR-18a-5p PRKACB 2.29585803678176 4.13931899001596e-14 -0.258632386178568 0.620572444315033 miRNATAP -0.109828861303179 0.000270889162356874 NA NA NA hsa-miR-18a-5p PSD3 2.29585803678176 4.13931899001596e-14 -1.07814986077885 0.0323687013905804 MirTarget;miRNATAP -0.328605773072599 1.77038091254639e-18 NA NA NA hsa-miR-18a-5p PTEN 2.29585803678176 4.13931899001596e-14 -0.679266578822795 0.257263534525925 miRNAWalker2_validate;miRTarBase -0.135863155421297 1.28041670903141e-19 24681249;27291152 However higher levels of the miR-17~92 cluster switched from PTEN to oncogenes including Ctnnb1 β-catenin via miR-18a which resulted in inhibition of tumor growth and metastasis;miR 18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN PI3K AKT mTOR signaling axis metastasis; colon cancer;esophageal cancer hsa-miR-18a-5p PTGR2 2.29585803678176 4.13931899001596e-14 -0.777783849276348 0.0456839338083314 mirMAP -0.184357353835607 2.38040349373915e-28 NA NA NA hsa-miR-18a-5p RAB11FIP2 2.29585803678176 4.13931899001596e-14 -0.195186300969823 0.62504337863968 miRNATAP -0.131419776760754 1.41019834295424e-20 NA NA NA hsa-miR-18a-5p RASSF3 2.29585803678176 4.13931899001596e-14 0.0816427024517807 0.807814524136362 miRNAWalker2_validate -0.119286529464504 5.34516181306598e-05 NA NA NA hsa-miR-18a-5p REPS2 2.29585803678176 4.13931899001596e-14 -1.7086889265294 0.000515429803981464 miRNATAP -0.336091234448453 3.36601961780141e-25 NA NA NA hsa-miR-18a-5p RIC3 2.29585803678176 4.13931899001596e-14 0.204763283680409 0.526669153736985 MirTarget -0.173325578344466 0.00105174522994952 NA NA NA hsa-miR-18a-5p RICTOR 2.29585803678176 4.13931899001596e-14 -0.38363074704787 0.426040024248714 miRNAWalker2_validate -0.115801044552433 7.86023931866078e-13 NA NA NA hsa-miR-18a-5p RIMS4 2.29585803678176 4.13931899001596e-14 -3.89846167236698 2.86202829464093e-19 mirMAP -0.416951868244038 5.72613913864664e-11 NA NA NA hsa-miR-18a-5p RNF157 2.29585803678176 4.13931899001596e-14 -0.983348924038851 0.00168399891767057 miRNAWalker2_validate -0.243397382730955 4.64692012386867e-12 NA NA NA hsa-miR-18a-5p ROBO2 2.29585803678176 4.13931899001596e-14 -3.25296458550521 1.00896676774904e-16 miRNATAP -0.507935667314834 4.30543821372391e-14 NA NA NA hsa-miR-18a-5p RORA 2.29585803678176 4.13931899001596e-14 -0.123520018727088 0.749873453545264 MirTarget;miRNATAP -0.159888453401577 1.01092266626298e-16 NA NA NA hsa-miR-18a-5p RPS6KA5 2.29585803678176 4.13931899001596e-14 -0.819186707092898 0.0108289170870186 MirTarget -0.304839062313663 1.17673769849974e-37 NA NA NA hsa-miR-18a-5p RUNX1 2.29585803678176 4.13931899001596e-14 -0.43096624121027 0.529704329917926 miRNATAP -0.159910187601787 2.2967282372377e-20 NA NA NA hsa-miR-18a-5p SDC4 2.29585803678176 4.13931899001596e-14 -0.285803974421723 0.701837635110456 MirTarget -0.13009744301677 2.38243911448905e-12 NA NA NA hsa-miR-18a-5p SERTAD3 2.29585803678176 4.13931899001596e-14 -0.659287453942884 0.195193788811259 miRNAWalker2_validate -0.105493496016499 4.6995939584212e-12 NA NA NA hsa-miR-18a-5p SH3BP4 2.29585803678176 4.13931899001596e-14 -0.908151212052202 0.148172820612864 miRNATAP -0.257507232453363 1.27695549003647e-39 NA NA NA hsa-miR-18a-5p SH3RF1 2.29585803678176 4.13931899001596e-14 -0.548328317481301 0.277867656818969 miRNATAP -0.151588008583245 1.53940609351226e-17 NA NA NA hsa-miR-18a-5p SLC27A1 2.29585803678176 4.13931899001596e-14 -0.531836694440708 0.307003508220529 mirMAP -0.170803449949827 5.12930789705189e-24 NA NA NA hsa-miR-18a-5p SLC35E2B 2.29585803678176 4.13931899001596e-14 -0.593753169013586 0.351595415426374 mirMAP -0.126416933557067 6.84911566025307e-18 NA NA NA hsa-miR-18a-5p SMAD3 2.29585803678176 4.13931899001596e-14 -0.634620777185637 0.245352362300656 miRNAWalker2_validate -0.145191271950291 4.28063578565896e-20 23249750 The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling glioblastoma hsa-miR-18a-5p SNED1 2.29585803678176 4.13931899001596e-14 -1.1948779970144 0.00962183847217995 mirMAP -0.319040754684096 5.13107237957617e-46 NA NA NA hsa-miR-18a-5p SNURF 2.29585803678176 4.13931899001596e-14 -1.28249234268988 4.3317666709386e-06 MirTarget -0.35021993981869 1.67687544409287e-15 NA NA NA hsa-miR-18a-5p SNX33 2.29585803678176 4.13931899001596e-14 -0.306143719309898 0.545887576158478 mirMAP -0.111579364347877 2.34163849455721e-25 NA NA NA hsa-miR-18a-5p SORBS2 2.29585803678176 4.13931899001596e-14 0.685421986210024 0.197688125344388 MirTarget;miRNATAP -0.120505517582452 0.000739455687797636 NA NA NA hsa-miR-18a-5p SSTR1 2.29585803678176 4.13931899001596e-14 -1.42180151727989 9.13650468007881e-07 mirMAP -0.528324795520575 1.56756939407685e-30 NA NA NA hsa-miR-18a-5p ST6GAL2 2.29585803678176 4.13931899001596e-14 -1.17110612856311 0.000157851090404832 mirMAP -0.270495142030909 9.4894012713475e-13 NA NA NA hsa-miR-18a-5p STX1B 2.29585803678176 4.13931899001596e-14 -0.70885443839874 0.000415318844266855 mirMAP -0.232229169453795 9.28428200268792e-16 NA NA NA hsa-miR-18a-5p SYT15 2.29585803678176 4.13931899001596e-14 0.412298480523128 0.110892603988312 MirTarget -0.108266350583212 0.000935039095132359 NA NA NA hsa-miR-18a-5p SYT7 2.29585803678176 4.13931899001596e-14 -0.606335876041531 0.294799348790941 mirMAP -0.104422314630191 0.000315556188007855 NA NA NA hsa-miR-18a-5p TAOK1 2.29585803678176 4.13931899001596e-14 -0.581019679787719 0.132484045479885 MirTarget;miRNATAP -0.242306979841869 7.7801284064685e-11 NA NA NA hsa-miR-18a-5p TGFBR2 2.29585803678176 4.13931899001596e-14 -0.246514824067334 0.7050497614235 miRNAWalker2_validate -0.233316456798081 1.26332307500906e-18 NA NA NA hsa-miR-18a-5p TGFBR3 2.29585803678176 4.13931899001596e-14 -0.250325459308409 0.65335981637459 MirTarget -0.374834046066299 3.17870910707835e-19 NA NA NA hsa-miR-18a-5p THBS1 2.29585803678176 4.13931899001596e-14 -0.497430447016999 0.534063430907669 MirTarget -0.181152396860618 8.69562380186631e-14 NA NA NA hsa-miR-18a-5p THRA 2.29585803678176 4.13931899001596e-14 -0.727752573193046 0.14565562737712 miRNAWalker2_validate -0.15778559532931 1.4522589546335e-15 NA NA NA hsa-miR-18a-5p THRB 2.29585803678176 4.13931899001596e-14 -1.20141153466674 0.00835555391894914 MirTarget -0.382941858083479 3.6050052574153e-41 NA NA NA hsa-miR-18a-5p TLE3 2.29585803678176 4.13931899001596e-14 -0.977701039165161 0.115292568887508 miRNAWalker2_validate -0.175378552602682 7.02951783854717e-27 NA NA NA hsa-miR-18a-5p TNS1 2.29585803678176 4.13931899001596e-14 -0.42937300584437 0.549551979636777 mirMAP -0.277210513830642 4.31505251632845e-24 NA NA NA hsa-miR-18a-5p TP73 2.29585803678176 4.13931899001596e-14 -0.969314477633702 4.14781484323786e-05 mirMAP -0.22065384786784 1.19104385169831e-09 NA NA NA hsa-miR-18a-5p TRAF5 2.29585803678176 4.13931899001596e-14 -0.689593424758659 0.151568111238617 MirTarget -0.128267488900121 9.95478770535342e-11 NA NA NA hsa-miR-18a-5p TRIM8 2.29585803678176 4.13931899001596e-14 -0.590377783634488 0.353695939097395 MirTarget -0.139326895343003 1.27470825650245e-30 NA NA NA hsa-miR-18a-5p TSC22D3 2.29585803678176 4.13931899001596e-14 -1.3795836952834 0.0489153581437252 miRNAWalker2_validate -0.271271829119523 9.73837470551859e-41 NA NA NA hsa-miR-18a-5p TSHZ3 2.29585803678176 4.13931899001596e-14 -0.676781346106153 0.0612682832400892 MirTarget;miRNATAP -0.215971774081914 6.12464974769798e-23 NA NA NA hsa-miR-18a-5p TTC28 2.29585803678176 4.13931899001596e-14 -0.63422143702943 0.146403869409613 mirMAP -0.290608470141428 6.51531949277842e-48 NA NA NA hsa-miR-18a-5p TTC8 2.29585803678176 4.13931899001596e-14 -1.16936275744825 0.00767535489157052 MirTarget -0.24444297545988 5.60419117331458e-55 NA NA NA hsa-miR-18a-5p TXNDC15 2.29585803678176 4.13931899001596e-14 -0.403856914939906 0.45918490247153 miRNAWalker2_validate -0.108922503750806 3.52469179828444e-31 NA NA NA hsa-miR-18a-5p UHMK1 2.29585803678176 4.13931899001596e-14 -0.532388644879841 0.193869381638697 miRNATAP -0.254562737421541 1.60229076446917e-11 NA NA NA hsa-miR-18a-5p VPS13D 2.29585803678176 4.13931899001596e-14 -0.262837192896913 0.656954489284649 MirTarget -0.163352521407886 1.25880658562137e-29 NA NA NA hsa-miR-18a-5p XYLT1 2.29585803678176 4.13931899001596e-14 -0.0239401352903696 0.956102171778929 MirTarget -0.113201024754998 1.49525425618871e-05 NA NA NA hsa-miR-18a-5p ZBTB4 2.29585803678176 4.13931899001596e-14 -0.644129464530789 0.315506647558687 MirTarget;miRNATAP -0.218847139499072 1.58588190258769e-65 NA NA NA hsa-miR-18a-5p ZBTB47 2.29585803678176 4.13931899001596e-14 -0.34886522302334 0.433081541452101 MirTarget -0.10967547693471 2.2467163994578e-13 NA NA NA hsa-miR-18a-5p ZCCHC24 2.29585803678176 4.13931899001596e-14 -0.940639634957249 0.0782754379791871 MirTarget -0.332163751402921 1.12163955486112e-47 NA NA NA hsa-miR-18a-5p ZDHHC15 2.29585803678176 4.13931899001596e-14 0.233337391259449 0.287055623445756 MirTarget -0.175569943139667 9.99000475354889e-08 NA NA NA hsa-miR-18a-5p ZHX3 2.29585803678176 4.13931899001596e-14 -0.372360490732095 0.446212424048541 mirMAP -0.135125456428399 8.09976396484113e-19 NA NA NA hsa-miR-18a-5p ZMYND8 2.29585803678176 4.13931899001596e-14 -0.59994862703731 0.254720411220157 miRNAWalker2_validate -0.103030104846277 4.59170526405068e-10 NA NA NA hsa-miR-18a-5p ZNF365 2.29585803678176 4.13931899001596e-14 -1.00295581283367 3.33706198333143e-06 MirTarget -0.232858888731592 1.45970435051874e-14 NA NA NA hsa-miR-18a-5p ZNF445 2.29585803678176 4.13931899001596e-14 -0.294532655288207 0.507355016281445 mirMAP -0.109228839358004 1.16702328434072e-20 NA NA NA hsa-miR-18a-5p ZNF703 2.29585803678176 4.13931899001596e-14 -2.50586372969953 1.76003330852868e-07 miRNAWalker2_validate -0.407959604276437 3.01410946735778e-28 NA NA NA hsa-miR-18a-5p ZNF704 2.29585803678176 4.13931899001596e-14 -0.676747931662059 0.0568076478498075 miRNATAP -0.25806685162268 9.87356201874314e-17 NA NA NA hsa-miR-18a-5p ZNF770 2.29585803678176 4.13931899001596e-14 -0.18770276558629 0.70527059698313 miRNAWalker2_validate -0.110595044268989 1.58179475254364e-11 NA NA NA hsa-miR-18a-5p ZSWIM6 2.29585803678176 4.13931899001596e-14 -0.459829863607944 0.232476837353957 miRNAWalker2_validate -0.104021047013898 8.50443666866863e-10 NA NA NA