miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-141-3p ABL1 0.730011517758706 0.000120338355004032 0.0849974459663763 0.36039518968777 MirTarget -0.195685516424929 5.69172755372042e-22 NA NA NA hsa-miR-149-5p ABL1 0.443278770827687 0.0642022866136881 0.0849974459663763 0.36039518968777 miRNAWalker2_validate -0.119524446807528 3.96367502239966e-13 NA NA NA hsa-miR-19a-3p ABL1 1.35800152353624 2.80940447111944e-12 0.0849974459663763 0.36039518968777 mirMAP -0.165948125062023 3.91300650024682e-17 NA NA NA hsa-miR-200a-3p ABL1 0.607140814457753 0.00289840524858752 0.0849974459663763 0.36039518968777 MirTarget -0.167516745460652 1.77198024575116e-18 NA NA NA hsa-miR-203a-3p ABL1 0.0441399794719697 0.880456392176704 0.0849974459663763 0.36039518968777 miRTarBase -0.112778482819384 2.7156053901475e-17 21454413 Treatment of lymphoma B cells with demethylating agents led to increased miR-203 expression and the concomitant downregulation of ABL1 confirming the epigenetic regulation of this miRNA; In summary our results show that the transformation from gastritis to MALT lymphoma is epigenetically regulated by miR-203 promoter methylation and identify ABL1 as a novel target for the treatment of this malignancy lymphoma hsa-miR-29a-5p ABL1 0.323252792625584 0.0370417231222825 0.0849974459663763 0.36039518968777 MirTarget -0.102953622277546 7.34902427999851e-05 NA NA NA hsa-miR-29b-3p ABL1 -0.110721443686039 0.511264554091106 0.0849974459663763 0.36039518968777 miRNATAP -0.146475892102919 5.88550435188412e-10 NA NA NA hsa-miR-30b-5p ABL1 -0.400238605368173 0.00346540992719245 0.0849974459663763 0.36039518968777 MirTarget;miRNATAP -0.172952437426206 2.83461995910967e-09 NA NA NA hsa-miR-30c-5p ABL1 0.021222006155897 0.886366656528128 0.0849974459663763 0.36039518968777 MirTarget;miRNATAP -0.18970460046346 1.27944212904127e-12 NA NA NA hsa-let-7g-5p ABL2 -0.250780249469264 0.00939610188330072 1.09524622627639 5.63545699438722e-20 miRNATAP -0.26023228088223 3.61011211445506e-06 NA NA NA hsa-miR-106a-5p ABL2 0.67978010057847 0.00221925869726092 1.09524622627639 5.63545699438722e-20 MirTarget -0.12081723681897 5.13904569570084e-07 NA NA NA hsa-miR-125b-5p ABL2 -0.993460109818276 5.07736727659894e-12 1.09524622627639 5.63545699438722e-20 MirTarget -0.281439049736819 5.36562374784411e-15 NA NA NA hsa-miR-126-5p ABL2 -0.953529188793816 7.91719143295591e-16 1.09524622627639 5.63545699438722e-20 mirMAP -0.199007532356064 7.34719306931467e-06 NA NA NA hsa-miR-1266-5p ABL2 -0.595481713934774 0.0201336437562675 1.09524622627639 5.63545699438722e-20 MirTarget -0.136362841553284 1.13754191519268e-10 NA NA NA hsa-miR-139-5p ABL2 -1.46099200329485 7.85040381494472e-22 1.09524622627639 5.63545699438722e-20 miRanda -0.144316367463431 2.20283257246018e-05 NA NA NA hsa-miR-140-3p ABL2 -0.967453553824782 7.6999446305445e-23 1.09524622627639 5.63545699438722e-20 miRNAWalker2_validate -0.255349238560977 1.29666059371703e-06 NA NA NA hsa-miR-141-3p ABL2 0.730011517758706 0.000120338355004032 1.09524622627639 5.63545699438722e-20 MirTarget;TargetScan;miRNATAP -0.163327870632464 5.45290744135633e-09 NA NA NA hsa-miR-141-5p ABL2 0.623874471326586 0.0018690552472983 1.09524622627639 5.63545699438722e-20 MirTarget;miRNATAP -0.121813658357402 5.15993862006625e-06 NA NA NA hsa-miR-146a-5p ABL2 -0.0201236699646614 0.905882759106561 1.09524622627639 5.63545699438722e-20 MirTarget;mirMAP -0.139981735608251 1.00525565291311e-05 NA NA NA hsa-miR-148a-5p ABL2 -1.00478606532747 1.38045244999229e-07 1.09524622627639 5.63545699438722e-20 miRNATAP -0.109488303840572 8.9292837183065e-05 NA NA NA hsa-miR-15a-5p ABL2 0.783550182002274 2.60699595655907e-11 1.09524622627639 5.63545699438722e-20 MirTarget;miRNATAP -0.134510664852072 0.00304452104556664 NA NA NA hsa-miR-17-3p ABL2 -0.0127974722290336 0.909559935689875 1.09524622627639 5.63545699438722e-20 mirMAP -0.15508751528889 0.0013471728888297 NA NA NA hsa-miR-181c-5p ABL2 -0.168991199007857 0.196949106150297 1.09524622627639 5.63545699438722e-20 mirMAP -0.283958069849431 3.09978809745386e-12 NA NA NA hsa-miR-195-5p ABL2 -1.8367376818177 6.9944883988895e-31 1.09524622627639 5.63545699438722e-20 MirTarget;miRNATAP -0.113976412143074 0.000369603718342823 NA NA NA hsa-miR-200a-3p ABL2 0.607140814457753 0.00289840524858752 1.09524622627639 5.63545699438722e-20 MirTarget;miRNATAP -0.194678675329018 5.14075721508106e-14 NA NA NA hsa-miR-200a-5p ABL2 0.701063526850019 0.000188402923774663 1.09524622627639 5.63545699438722e-20 mirMAP -0.163695878493146 7.60784587837007e-09 NA NA NA hsa-miR-200b-3p ABL2 0.0717138787925347 0.682858087587209 1.09524622627639 5.63545699438722e-20 MirTarget -0.244095965879956 4.64349655046989e-16 NA NA NA hsa-miR-200b-5p ABL2 0.02621402664548 0.883725338810228 1.09524622627639 5.63545699438722e-20 mirMAP -0.181255302207614 1.24378281894122e-09 NA NA NA hsa-miR-200c-3p ABL2 0.630251054099546 0.000131975031451555 1.09524622627639 5.63545699438722e-20 MirTarget -0.126490491832731 0.000103152737202785 NA NA NA hsa-miR-20b-5p ABL2 0.345967670847176 0.232014828043601 1.09524622627639 5.63545699438722e-20 MirTarget -0.130972239874756 8.5857373275265e-13 NA NA NA hsa-miR-218-5p ABL2 -1.0725338636959 3.61493686604269e-09 1.09524622627639 5.63545699438722e-20 mirMAP -0.12630332501695 1.51357370171693e-05 NA NA NA hsa-miR-26a-2-3p ABL2 -0.444498687388748 0.00325793861409413 1.09524622627639 5.63545699438722e-20 MirTarget;mirMAP -0.185333359506245 1.80293938736268e-07 NA NA NA hsa-miR-26a-5p ABL2 -1.09269574587169 1.24020612216319e-22 1.09524622627639 5.63545699438722e-20 MirTarget;miRNATAP -0.210032342423551 6.10064362441754e-06 NA NA NA hsa-miR-26b-5p ABL2 -0.254478038884324 0.0285227763044636 1.09524622627639 5.63545699438722e-20 MirTarget;miRNATAP -0.232269194249 5.68960650442092e-07 NA NA NA hsa-miR-27b-3p ABL2 -0.732682718863563 2.26896143573324e-09 1.09524622627639 5.63545699438722e-20 MirTarget;miRNATAP -0.314367887495306 1.9073749164767e-13 NA NA NA hsa-miR-29a-3p ABL2 -1.26881270980079 2.82496991513463e-22 1.09524622627639 5.63545699438722e-20 mirMAP -0.151340986103327 0.000137237385900614 NA NA NA hsa-miR-29b-2-5p ABL2 -0.502720326849742 0.000730448246894952 1.09524622627639 5.63545699438722e-20 mirMAP -0.268419788443379 3.76418587083129e-14 NA NA NA hsa-miR-29b-3p ABL2 -0.110721443686039 0.511264554091106 1.09524622627639 5.63545699438722e-20 mirMAP -0.180577843257978 1.37410111177913e-08 NA NA NA hsa-miR-29c-3p ABL2 -2.08166260448948 8.3238369390898e-24 1.09524622627639 5.63545699438722e-20 mirMAP -0.188770195561106 9.15396968107283e-15 NA NA NA hsa-miR-30a-5p ABL2 -1.79779915425811 1.93360169837799e-26 1.09524622627639 5.63545699438722e-20 mirMAP;miRNATAP -0.180437408071179 1.90318182883753e-09 NA NA NA hsa-miR-30b-5p ABL2 -0.400238605368173 0.00346540992719245 1.09524622627639 5.63545699438722e-20 mirMAP -0.252193993355332 9.19067158453704e-11 NA NA NA hsa-miR-30c-5p ABL2 0.021222006155897 0.886366656528128 1.09524622627639 5.63545699438722e-20 mirMAP;miRNATAP -0.205214638297551 1.38717882631865e-08 NA NA NA hsa-miR-30d-3p ABL2 -0.577371911152798 2.02950840095287e-06 1.09524622627639 5.63545699438722e-20 mirMAP -0.339367817973124 4.76775052224965e-15 NA NA NA hsa-miR-30d-5p ABL2 -0.38399848121878 0.000171129616944749 1.09524622627639 5.63545699438722e-20 mirMAP;miRNATAP -0.320611504130442 9.55316369897912e-10 NA NA NA hsa-miR-30e-3p ABL2 -0.890635378639789 1.65740480611339e-16 1.09524622627639 5.63545699438722e-20 mirMAP -0.261783843791186 6.51659713633331e-08 NA NA NA hsa-miR-30e-5p ABL2 -1.02114836019762 6.81961221797866e-17 1.09524622627639 5.63545699438722e-20 mirMAP -0.422200879560975 1.1056206898839e-24 NA NA NA hsa-miR-335-5p ABL2 -1.17227779671552 1.49282618530733e-10 1.09524622627639 5.63545699438722e-20 mirMAP -0.16901926187275 3.82895033012245e-09 NA NA NA hsa-miR-33a-3p ABL2 0.20371038027126 0.212335697664505 1.09524622627639 5.63545699438722e-20 mirMAP -0.139891580781392 3.03916605778206e-05 NA NA NA hsa-miR-374a-5p ABL2 -0.621903385111545 6.61791773205282e-12 1.09524622627639 5.63545699438722e-20 mirMAP -0.325467683854319 2.74091152038277e-08 NA NA NA hsa-miR-374b-5p ABL2 -0.288413933608091 0.0041474558664058 1.09524622627639 5.63545699438722e-20 mirMAP -0.197461049430654 0.00025688574119519 NA NA NA hsa-miR-378a-3p ABL2 -1.50453783521372 9.41694954361173e-17 1.09524622627639 5.63545699438722e-20 mirMAP -0.193807074311757 9.92891414761507e-12 NA NA NA hsa-miR-378c ABL2 -1.82618708894602 7.26454201089171e-22 1.09524622627639 5.63545699438722e-20 mirMAP -0.132352903764467 1.04449991228117e-06 NA NA NA hsa-miR-429 ABL2 0.559451508722375 0.00563641638673083 1.09524622627639 5.63545699438722e-20 MirTarget -0.156909111497101 2.65469389617911e-09 NA NA NA hsa-miR-497-5p ABL2 -0.966244470847844 5.26505649147857e-12 1.09524622627639 5.63545699438722e-20 MirTarget;miRNATAP -0.260608576331646 2.4907757219625e-12 NA NA NA hsa-miR-582-3p ABL2 -0.248056267546012 0.143798829508405 1.09524622627639 5.63545699438722e-20 PITA -0.142527303380499 7.16586935840365e-06 NA NA NA hsa-miR-590-3p ABL2 0.221436901462551 0.0965904764063157 1.09524622627639 5.63545699438722e-20 PITA;mirMAP;miRNATAP -0.108477525153029 0.00782234823818227 NA NA NA hsa-miR-139-5p AKT3 -1.46099200329485 7.85040381494472e-22 0.757395805826156 5.24354425444781e-05 PITA;miRanda -0.204988506808972 7.26517518198736e-05 NA NA NA hsa-miR-15a-5p AKT3 0.783550182002274 2.60699595655907e-11 0.757395805826156 5.24354425444781e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265716982670402 0.000109391971495535 NA NA NA hsa-miR-17-5p AKT3 1.41924888736771 2.75805544953758e-18 0.757395805826156 5.24354425444781e-05 TargetScan;miRNATAP -0.210478431167346 1.46778910374435e-05 NA NA NA hsa-miR-205-3p AKT3 1.2960640797621 5.80786479909147e-11 0.757395805826156 5.24354425444781e-05 mirMAP -0.248708307357298 5.71786142986847e-10 NA NA NA hsa-miR-20a-5p AKT3 1.1531986665452 1.02385132917958e-11 0.757395805826156 5.24354425444781e-05 miRNATAP -0.244010493055021 2.19437052623105e-07 NA NA NA hsa-miR-29b-3p AKT3 -0.110721443686039 0.511264554091106 0.757395805826156 5.24354425444781e-05 miRNATAP -0.255169036216248 1.32894370465011e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-362-3p AKT3 -0.697212068252854 2.61718493418184e-06 0.757395805826156 5.24354425444781e-05 miRanda -0.198442787422331 0.000314248564221821 NA NA NA hsa-miR-362-5p AKT3 0.41089772861323 0.0404254902071382 0.757395805826156 5.24354425444781e-05 PITA;TargetScan;miRNATAP -0.156881795440952 0.000120211641903581 NA NA NA hsa-miR-429 ANGPT1 0.559451508722375 0.00563641638673083 -0.994659806908684 0.000102297444730898 miRanda -0.2797916675188 3.51642052342136e-07 NA NA NA hsa-miR-590-3p ANGPT1 0.221436901462551 0.0965904764063157 -0.994659806908684 0.000102297444730898 PITA;miRanda;mirMAP -0.260652523349808 0.00203849703312725 NA NA NA hsa-miR-944 ANGPT1 1.47323925060177 2.61626403984929e-13 -0.994659806908684 0.000102297444730898 PITA;mirMAP -0.323166948397416 1.72218448279528e-09 NA NA NA hsa-miR-148a-5p ANGPT2 -1.00478606532747 1.38045244999229e-07 1.60682659917739 3.22512104906665e-21 mirMAP -0.111398410451088 0.00531513825463852 NA NA NA hsa-miR-19b-3p ANGPT2 0.538732279378089 0.000622008277870679 1.60682659917739 3.22512104906665e-21 MirTarget -0.142908635743858 0.00344056723294101 NA NA NA hsa-miR-374a-5p ANGPT2 -0.621903385111545 6.61791773205282e-12 1.60682659917739 3.22512104906665e-21 mirMAP -0.411120960907931 9.09637924296375e-07 NA NA NA hsa-miR-374b-5p ANGPT2 -0.288413933608091 0.0041474558664058 1.60682659917739 3.22512104906665e-21 mirMAP -0.368289519242387 1.53606293531056e-06 NA NA NA hsa-miR-429 ANGPT2 0.559451508722375 0.00563641638673083 1.60682659917739 3.22512104906665e-21 miRanda -0.188271200316882 6.15570379949398e-07 NA NA NA hsa-miR-582-5p ANGPT2 -0.0366995972742474 0.821827119138923 1.60682659917739 3.22512104906665e-21 mirMAP -0.168812520671104 0.000363324472297187 NA NA NA hsa-miR-664a-3p ANGPT2 -0.256108763664991 0.0513188660751664 1.60682659917739 3.22512104906665e-21 mirMAP -0.314343374722018 6.99960306928084e-08 NA NA NA hsa-miR-103a-3p ARF6 0.556219385347418 1.55815736455067e-09 -0.42656469970065 2.94288025403766e-06 miRNAWalker2_validate;MirTarget -0.138635785672278 0.00133228768683732 NA NA NA hsa-miR-128-3p ARF6 -0.170677254601174 0.20412808476528 -0.42656469970065 2.94288025403766e-06 miRNAWalker2_validate -0.135316624497919 5.29290143351344e-06 NA NA NA hsa-miR-132-3p ARF6 0.237841736463996 0.00653466538179383 -0.42656469970065 2.94288025403766e-06 miRNAWalker2_validate -0.198289856493552 1.66257226390682e-05 NA NA NA hsa-miR-145-5p ARF6 -0.46917511594055 0.000685297625493134 -0.42656469970065 2.94288025403766e-06 MirTarget -0.102288829612554 0.000396128442914943 25253741 lincRNA RoR and miR 145 regulate invasion in triple negative breast cancer via targeting ARF6 breast cancer hsa-miR-181a-5p ARF6 0.819060835827404 1.38616688310277e-13 -0.42656469970065 2.94288025403766e-06 miRNAWalker2_validate;MirTarget -0.203303008700993 6.79950657478327e-09 NA NA NA hsa-miR-181b-5p ARF6 0.974255518824355 2.64876280203475e-16 -0.42656469970065 2.94288025403766e-06 MirTarget -0.166072473455378 3.28816557222742e-07 NA NA NA hsa-miR-181c-5p ARF6 -0.168991199007857 0.196949106150297 -0.42656469970065 2.94288025403766e-06 MirTarget -0.153370100094629 4.7095147332918e-07 NA NA NA hsa-miR-181d-5p ARF6 0.367649966373544 0.00537300571455306 -0.42656469970065 2.94288025403766e-06 MirTarget -0.222440402835241 6.43232827735317e-14 NA NA NA hsa-miR-199a-5p ARF6 -0.364835768178638 0.0435119211101981 -0.42656469970065 2.94288025403766e-06 MirTarget;PITA;miRanda;miRNATAP -0.104291388762182 2.10678884588468e-06 NA NA NA hsa-miR-218-5p ARF6 -1.0725338636959 3.61493686604269e-09 -0.42656469970065 2.94288025403766e-06 MirTarget -0.151688568242962 9.63298109103215e-13 NA NA NA hsa-miR-28-3p ARF6 0.459875450032895 3.47095927872566e-07 -0.42656469970065 2.94288025403766e-06 MirTarget;PITA;miRNATAP -0.224470262372484 3.41164497566306e-07 NA NA NA hsa-miR-30e-3p ARF6 -0.890635378639789 1.65740480611339e-16 -0.42656469970065 2.94288025403766e-06 MirTarget;miRNATAP -0.101092957062656 0.00521150312840682 NA NA NA hsa-miR-485-3p ARF6 0.359155046663542 0.0929405338270575 -0.42656469970065 2.94288025403766e-06 PITA -0.10873364339623 4.78413996459482e-09 NA NA NA hsa-miR-628-5p ARF6 -0.554239048796013 4.92386883216087e-05 -0.42656469970065 2.94288025403766e-06 PITA -0.114035006845858 8.98913661716811e-05 NA NA NA hsa-miR-127-3p BAD -1.47175957435172 9.8707469067377e-14 0.232698220027489 0.0410974615650229 miRanda;miRNATAP -0.109748766939369 6.41360405115286e-06 NA NA NA hsa-miR-326 BAD -0.425943992128769 0.0415010315530797 0.232698220027489 0.0410974615650229 miRanda -0.161061952496571 5.50625637973764e-12 NA NA NA hsa-let-7b-3p BDNF 0.120166961637302 0.299224004314356 0.0408778714112631 0.883450816679916 MirTarget;miRNATAP -0.485153955582307 3.78595524866656e-06 NA NA NA hsa-miR-142-5p BDNF 0.288897753038094 0.0900009317815725 0.0408778714112631 0.883450816679916 mirMAP -0.308543354723933 1.36682819592341e-05 NA NA NA hsa-miR-146b-5p BDNF 0.917975986853978 3.33749259316025e-09 0.0408778714112631 0.883450816679916 miRanda -0.295426001779662 0.000122805573761243 NA NA NA hsa-miR-155-5p BDNF 0.533437622040649 0.00248671179205372 0.0408778714112631 0.883450816679916 miRNATAP -0.22678558150571 0.000944767256917019 NA NA NA hsa-miR-22-3p BDNF 0.00776313533473072 0.926356548861307 0.0408778714112631 0.883450816679916 miRNAWalker2_validate;miRTarBase -0.427506450899018 0.00361347435585047 NA NA NA hsa-miR-29b-1-5p BDNF 1.39669186711325 4.36960953138935e-11 0.0408778714112631 0.883450816679916 mirMAP -0.226952768941406 5.14949172622145e-05 NA NA NA hsa-miR-338-5p BDNF -1.71946558699173 2.62649071488641e-23 0.0408778714112631 0.883450816679916 miRNATAP -0.232361738096582 0.000529367225285524 NA NA NA hsa-miR-365a-3p BDNF 0.446833934952926 0.00233857759218299 0.0408778714112631 0.883450816679916 miRNATAP -0.31502366808888 0.000131395532237701 NA NA NA hsa-miR-424-5p BDNF 1.48125289532143 9.10372985713165e-19 0.0408778714112631 0.883450816679916 MirTarget;miRNATAP -0.283162731321444 4.92699422656507e-05 NA NA NA hsa-let-7d-5p CALM1 0.481757661442508 3.66030810124939e-07 -0.213167933096935 0.0132955123039906 miRNATAP -0.295003171876096 2.15641386747527e-14 NA NA NA hsa-let-7g-5p CALM1 -0.250780249469264 0.00939610188330072 -0.213167933096935 0.0132955123039906 miRNATAP -0.199836843853475 2.57819022092583e-07 NA NA NA hsa-let-7i-5p CALM1 0.249440992451337 0.00426823922424972 -0.213167933096935 0.0132955123039906 miRNATAP -0.145072024146197 0.000812990185839906 NA NA NA hsa-miR-140-3p CALM1 -0.967453553824782 7.6999446305445e-23 -0.213167933096935 0.0132955123039906 mirMAP -0.131638644121155 0.000334759806751531 NA NA NA hsa-miR-15a-5p CALM1 0.783550182002274 2.60699595655907e-11 -0.213167933096935 0.0132955123039906 miRNATAP -0.102498454548548 0.00109447751694815 NA NA NA hsa-miR-15b-5p CALM1 0.85315666454713 3.79816274836297e-12 -0.213167933096935 0.0132955123039906 miRNATAP -0.227875474808807 6.69378485232835e-15 NA NA NA hsa-miR-16-2-3p CALM1 1.1567130855258 1.01867256952189e-14 -0.213167933096935 0.0132955123039906 mirMAP -0.148106593272422 7.98737246993065e-10 NA NA NA hsa-miR-16-5p CALM1 0.521122945828175 1.40561786410572e-06 -0.213167933096935 0.0132955123039906 miRNATAP -0.225832401559966 3.15337373195989e-11 NA NA NA hsa-miR-181a-5p CALM1 0.819060835827404 1.38616688310277e-13 -0.213167933096935 0.0132955123039906 miRNATAP -0.147893580172583 7.64381126032014e-06 NA NA NA hsa-miR-181c-5p CALM1 -0.168991199007857 0.196949106150297 -0.213167933096935 0.0132955123039906 miRNATAP -0.230976619244145 1.32796598527633e-16 NA NA NA hsa-miR-186-5p CALM1 0.353452958261612 0.000145058448579496 -0.213167933096935 0.0132955123039906 mirMAP -0.14023221227938 0.000523412477865168 NA NA NA hsa-miR-195-3p CALM1 -0.624259620429699 0.000164279659144497 -0.213167933096935 0.0132955123039906 mirMAP -0.117643740301757 1.55923165142533e-07 NA NA NA hsa-miR-26a-5p CALM1 -1.09269574587169 1.24020612216319e-22 -0.213167933096935 0.0132955123039906 mirMAP -0.137257876136283 1.99425448380374e-05 NA NA NA hsa-miR-423-5p CALM1 0.60141781325829 1.62940950644999e-07 -0.213167933096935 0.0132955123039906 miRNATAP -0.175914819534119 4.27510682723903e-08 NA NA NA hsa-miR-497-5p CALM1 -0.966244470847844 5.26505649147857e-12 -0.213167933096935 0.0132955123039906 miRNATAP -0.121099109543472 3.46965228383924e-06 NA NA NA hsa-miR-505-3p CALM1 0.912823669571645 4.0549774967148e-13 -0.213167933096935 0.0132955123039906 mirMAP -0.174811395834141 1.29638415657209e-09 NA NA NA hsa-miR-7-1-3p CALM1 1.13646121619622 1.49823237535933e-14 -0.213167933096935 0.0132955123039906 mirMAP -0.14338889420152 4.34024983961694e-09 NA NA NA hsa-let-7b-3p CALM2 0.120166961637302 0.299224004314356 0.105699357017173 0.132578868935422 miRNATAP -0.101989462467186 0.000112736603049747 NA NA NA hsa-miR-27b-3p CALM3 -0.732682718863563 2.26896143573324e-09 0.352101073763208 4.53564472817932e-06 miRNAWalker2_validate;miRNATAP -0.194073706725085 2.71240482557659e-13 NA NA NA hsa-miR-106b-5p CDC42 0.50378717276868 1.45412404526866e-05 0.0129593551240648 0.846406884079324 miRNAWalker2_validate -0.131295640190421 9.81003904528409e-08 NA NA NA hsa-miR-107 CDC42 -0.0447040564279497 0.671618791096755 0.0129593551240648 0.846406884079324 miRanda -0.130309156837011 2.19468768424638e-06 23627613 Quantitative real-time PCR was used to analyze the expression of miR-107 and its bioinformatically identified targets PIM-1 and CDC42 esophageal cancer hsa-miR-28-3p CDC42 0.459875450032895 3.47095927872566e-07 0.0129593551240648 0.846406884079324 PITA -0.127737879674437 6.54245576973787e-05 NA NA NA hsa-miR-106b-5p CSF1 0.50378717276868 1.45412404526866e-05 -0.395344296512344 0.0366179306088304 miRNATAP -0.213141559996663 0.00262457932581044 NA NA NA hsa-miR-125a-5p CSF1 0.215366061934933 0.119550904549401 -0.395344296512344 0.0366179306088304 mirMAP -0.162177183821337 0.00673489115062628 NA NA NA hsa-miR-130a-3p CSF1 0.67051191119964 4.89747518735144e-06 -0.395344296512344 0.0366179306088304 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.338819425385429 7.70001056624161e-10 18823650 Finally downstream target validation was proven for the miR-130a whose downregulation was linked to the translational activation of the M-CSF gene a known resistance factor for ovarian cancer drug resistance ovarian cancer hsa-miR-130b-3p CSF1 1.44628430084411 9.13980959861273e-24 -0.395344296512344 0.0366179306088304 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.262150708520788 1.49996229073617e-06 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-149-5p CSF1 0.443278770827687 0.0642022866136881 -0.395344296512344 0.0366179306088304 MirTarget -0.346860531103734 3.22776460234644e-26 NA NA NA hsa-miR-15a-5p CSF1 0.783550182002274 2.60699595655907e-11 -0.395344296512344 0.0366179306088304 miRNATAP -0.338761477235692 8.10890401435535e-07 NA NA NA hsa-miR-17-5p CSF1 1.41924888736771 2.75805544953758e-18 -0.395344296512344 0.0366179306088304 TargetScan;miRNATAP -0.479743735078695 1.30867254370933e-24 NA NA NA hsa-miR-197-3p CSF1 0.878693269130833 3.84847526014135e-15 -0.395344296512344 0.0366179306088304 MirTarget -0.291321943129489 5.13467155279589e-05 NA NA NA hsa-miR-205-5p CSF1 1.50759485376634 2.0003886738248e-16 -0.395344296512344 0.0366179306088304 MirTarget -0.371318300807809 1.49636449226668e-18 NA NA NA hsa-miR-20a-5p CSF1 1.1531986665452 1.02385132917958e-11 -0.395344296512344 0.0366179306088304 miRNATAP -0.455232782593005 2.31942812972796e-23 NA NA NA hsa-miR-23a-5p CSF1 1.662156284689 7.34844237202118e-15 -0.395344296512344 0.0366179306088304 MirTarget -0.163568116201254 1.58835594610855e-05 NA NA NA hsa-miR-27a-3p CSF1 0.348456440505425 0.00126682892514312 -0.395344296512344 0.0366179306088304 MirTarget;miRNATAP -0.286646955208082 0.000175122490939345 NA NA NA hsa-miR-27b-3p CSF1 -0.732682718863563 2.26896143573324e-09 -0.395344296512344 0.0366179306088304 MirTarget;miRNATAP -0.183831160959538 0.00577489813734823 NA NA NA hsa-miR-301a-3p CSF1 2.14132004241926 4.46255413526808e-25 -0.395344296512344 0.0366179306088304 MirTarget;miRNATAP -0.290406683339765 4.06439220558199e-15 NA NA NA hsa-miR-30b-5p CSF1 -0.400238605368173 0.00346540992719245 -0.395344296512344 0.0366179306088304 miRNAWalker2_validate -0.291306091269383 1.12618459192728e-06 NA NA NA hsa-miR-30c-5p CSF1 0.021222006155897 0.886366656528128 -0.395344296512344 0.0366179306088304 miRNAWalker2_validate -0.294764158216072 9.36341876918087e-08 NA NA NA hsa-miR-429 CSF1 0.559451508722375 0.00563641638673083 -0.395344296512344 0.0366179306088304 PITA;miRanda;miRNATAP -0.412211261861765 1.97214914555001e-26 NA NA NA hsa-miR-454-3p CSF1 1.54137391927201 4.15861570449376e-20 -0.395344296512344 0.0366179306088304 MirTarget;miRNATAP -0.294100408482872 2.86733710923803e-10 NA NA NA hsa-miR-505-3p CSF1 0.912823669571645 4.0549774967148e-13 -0.395344296512344 0.0366179306088304 miRNAWalker2_validate -0.285574950736628 7.9792173361443e-06 NA NA NA hsa-miR-532-3p CSF1 0.80240056676907 1.08989551712617e-09 -0.395344296512344 0.0366179306088304 MirTarget;PITA -0.324635622209122 1.18763671452161e-07 NA NA NA hsa-miR-532-5p CSF1 -0.021857649390892 0.830992272120134 -0.395344296512344 0.0366179306088304 miRNATAP -0.451253318869355 2.05420161227854e-08 NA NA NA hsa-miR-708-5p CSF1 1.54207894190626 2.2887257992285e-19 -0.395344296512344 0.0366179306088304 miRNATAP -0.29285378224165 1.4910271560831e-10 NA NA NA hsa-miR-93-5p CSF1 1.61042951896619 5.1280369606967e-24 -0.395344296512344 0.0366179306088304 miRNATAP -0.421825156681646 1.26406597070088e-18 NA NA NA hsa-miR-940 CSF1 1.25303020594374 1.3005368359451e-10 -0.395344296512344 0.0366179306088304 MirTarget;PITA;miRNATAP -0.164486429826726 8.71705336652414e-05 NA NA NA hsa-miR-96-5p CSF1 1.42326703011157 4.39736150032373e-14 -0.395344296512344 0.0366179306088304 miRNATAP -0.451408210420024 5.06847835877813e-29 NA NA NA hsa-miR-339-5p CSF1R 1.07771430326938 2.45772601859307e-09 -0.158717133634124 0.439054074137574 miRanda -0.325967760517482 9.12881252755359e-12 NA NA NA hsa-miR-34c-5p CSF1R 0.565896455062849 0.0224052732281715 -0.158717133634124 0.439054074137574 MirTarget;miRanda;miRNATAP -0.139899378360785 9.55471978270924e-05 NA NA NA hsa-miR-30c-2-3p EFNA1 -1.82791447399693 2.41509888037865e-21 0.457367123980915 0.000509296121229094 MirTarget -0.166775455540874 3.79223687167938e-09 NA NA NA hsa-miR-326 EFNA1 -0.425943992128769 0.0415010315530797 0.457367123980915 0.000509296121229094 miRanda -0.145744922348379 9.95109469024053e-08 NA NA NA hsa-miR-486-5p EFNA1 -1.70341092285685 6.64232609099498e-14 0.457367123980915 0.000509296121229094 miRanda -0.109691489140236 7.72682845452763e-06 NA NA NA hsa-miR-2110 EFNA3 -0.097378294887309 0.534549425629295 -0.111220394827782 0.566844855883492 miRNATAP -0.206476937571905 0.000198360023193457 NA NA NA hsa-miR-30a-5p EFNA3 -1.79779915425811 1.93360169837799e-26 -0.111220394827782 0.566844855883492 MirTarget;mirMAP;miRNATAP -0.197379638816703 3.05633349594278e-05 NA NA NA hsa-miR-30d-5p EFNA3 -0.38399848121878 0.000171129616944749 -0.111220394827782 0.566844855883492 MirTarget;mirMAP;miRNATAP -0.224956414341343 0.00675214826558602 NA NA NA hsa-miR-30e-5p EFNA3 -1.02114836019762 6.81961221797866e-17 -0.111220394827782 0.566844855883492 MirTarget;mirMAP -0.321139349547888 1.53887283953078e-06 NA NA NA hsa-miR-326 EFNA3 -0.425943992128769 0.0415010315530797 -0.111220394827782 0.566844855883492 MirTarget;miRanda;miRNATAP -0.204598953828051 3.67018388138734e-07 NA NA NA hsa-miR-330-3p EFNA3 -0.0524949332825773 0.719856123539461 -0.111220394827782 0.566844855883492 PITA;miRNATAP -0.165081158771636 0.00444695403014315 NA NA NA hsa-miR-330-5p EFNA3 0.944693925383906 5.04972895657346e-13 -0.111220394827782 0.566844855883492 MirTarget;miRanda;miRNATAP -0.217813234348746 0.000577123937543295 NA NA NA hsa-miR-342-5p EFNA3 0.862385578881784 1.60007936373305e-08 -0.111220394827782 0.566844855883492 miRNATAP -0.183275894973583 0.000797872924763551 NA NA NA hsa-miR-361-3p EFNA3 0.272298288982435 0.0147874880476998 -0.111220394827782 0.566844855883492 MirTarget;miRNATAP -0.400801837123043 1.0410817796917e-07 NA NA NA hsa-miR-423-5p EFNA3 0.60141781325829 1.62940950644999e-07 -0.111220394827782 0.566844855883492 MirTarget;PITA;miRNATAP -0.36640935128474 4.49153292025969e-07 NA NA NA hsa-miR-491-5p EFNA3 -0.541680329196715 0.00135829217561865 -0.111220394827782 0.566844855883492 PITA;miRanda;miRNATAP -0.182445268929087 0.000463080296519282 NA NA NA hsa-miR-103a-2-5p EFNA5 1.37988337975616 6.74852943995612e-08 -1.22199137148167 6.86022378355376e-09 MirTarget -0.129179480031755 0.000978956647827604 NA NA NA hsa-miR-15b-3p EFNA5 1.05020782493504 6.38723677324836e-14 -1.22199137148167 6.86022378355376e-09 mirMAP -0.252313213888087 0.000101657831620038 NA NA NA hsa-miR-186-5p EFNA5 0.353452958261612 0.000145058448579496 -1.22199137148167 6.86022378355376e-09 mirMAP -0.292828668890667 0.00368270694047647 NA NA NA hsa-miR-19a-3p EFNA5 1.35800152353624 2.80940447111944e-12 -1.22199137148167 6.86022378355376e-09 miRNATAP -0.173259760034209 0.000215458020093004 NA NA NA hsa-miR-200c-3p EFNA5 0.630251054099546 0.000131975031451555 -1.22199137148167 6.86022378355376e-09 miRNATAP -0.153866238298602 0.00631541570613121 NA NA NA hsa-miR-20a-3p EFNA5 1.34885093664027 2.07697464119202e-12 -1.22199137148167 6.86022378355376e-09 mirMAP -0.144555053766916 0.00234983429033761 NA NA NA hsa-miR-21-3p EFNA5 1.25126438776674 2.4124216716282e-17 -1.22199137148167 6.86022378355376e-09 mirMAP -0.212067504812099 0.00052479558203858 NA NA NA hsa-miR-29b-3p EFNA5 -0.110721443686039 0.511264554091106 -1.22199137148167 6.86022378355376e-09 miRNATAP -0.211686837406341 0.000128497934345782 NA NA NA hsa-miR-335-3p EFNA5 0.336785882180547 0.0542446207938138 -1.22199137148167 6.86022378355376e-09 mirMAP -0.150919557175587 0.00465235729404315 NA NA NA hsa-miR-342-3p EFNA5 0.99756868977753 9.28499866272332e-10 -1.22199137148167 6.86022378355376e-09 miRNATAP -0.159591124129106 0.00464216956209919 NA NA NA hsa-miR-421 EFNA5 0.945488088619653 2.35762398527362e-09 -1.22199137148167 6.86022378355376e-09 mirMAP -0.160644495427995 0.00584038318557551 NA NA NA hsa-miR-429 EFNA5 0.559451508722375 0.00563641638673083 -1.22199137148167 6.86022378355376e-09 miRNATAP -0.122314534852078 0.00790652775501798 NA NA NA hsa-miR-450b-5p EFNA5 1.25529820885833 1.18847120528666e-15 -1.22199137148167 6.86022378355376e-09 mirMAP -0.166416099398179 0.00403604528451531 NA NA NA hsa-miR-501-5p EFNA5 1.02806906860218 1.63456814370548e-09 -1.22199137148167 6.86022378355376e-09 mirMAP -0.167180585616505 0.00219909263230495 NA NA NA hsa-miR-590-3p EFNA5 0.221436901462551 0.0965904764063157 -1.22199137148167 6.86022378355376e-09 miRanda;mirMAP -0.245530633460186 0.000461995983518845 NA NA NA hsa-miR-7-1-3p EFNA5 1.13646121619622 1.49823237535933e-14 -1.22199137148167 6.86022378355376e-09 mirMAP -0.312382585886428 3.10545686694962e-07 NA NA NA hsa-miR-92a-3p EFNA5 0.994679542307232 1.32587679156217e-16 -1.22199137148167 6.86022378355376e-09 miRNAWalker2_validate -0.252250236327487 0.00083049459351438 NA NA NA hsa-miR-944 EFNA5 1.47323925060177 2.61626403984929e-13 -1.22199137148167 6.86022378355376e-09 mirMAP -0.124709385029952 0.0057940911309002 NA NA NA hsa-miR-96-5p EFNA5 1.42326703011157 4.39736150032373e-14 -1.22199137148167 6.86022378355376e-09 TargetScan -0.163995701344485 0.00065815164886802 NA NA NA hsa-miR-590-3p EGF 0.221436901462551 0.0965904764063157 -2.10075991194281 5.08275628156253e-09 miRanda -0.330881763767121 0.00576591126865384 NA NA NA hsa-miR-629-3p EGF 1.43262037314105 2.37092217984413e-19 -2.10075991194281 5.08275628156253e-09 miRNATAP -0.795198092528241 2.00645853141744e-17 NA NA NA hsa-miR-125a-5p EGFR 0.215366061934933 0.119550904549401 0.421988255273135 0.0732089026211386 mirMAP -0.438449046612586 2.45858610383153e-09 19881956;27094723;24484870 We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3;Suppression of microRNA 125a 5p upregulates the TAZ EGFR signaling pathway and promotes retinoblastoma proliferation; Moreover the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo; Finally TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation; Taken together our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma;miR 125a regulates cell cycle proliferation and apoptosis by targeting the ErbB pathway in acute myeloid leukemia; Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a; Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML ;progression;progression ovarian cancer;retinoblastoma;acute myeloid leukemia hsa-miR-140-5p EGFR -0.412389003031485 0.000136051708543369 0.421988255273135 0.0732089026211386 miRanda -0.396347951906697 2.8829446407085e-05 NA NA NA hsa-miR-141-3p EGFR 0.730011517758706 0.000120338355004032 0.421988255273135 0.0732089026211386 MirTarget -0.172797280203478 0.00130092154204067 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-142-3p EGFR 1.12754191614028 1.68798138028946e-08 0.421988255273135 0.0732089026211386 miRanda -0.211213785673619 2.81655424599246e-05 NA NA NA hsa-miR-146a-5p EGFR -0.0201236699646614 0.905882759106561 0.421988255273135 0.0732089026211386 miRNAWalker2_validate -0.160035522858436 0.00817015681506167 25242818;22161865;25596948;24895573;25417703;23555954;24839931;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;progression;;;;;; pancreatic cancer;prostate cancer;breast cancer;liver cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-146b-5p EGFR 0.917975986853978 3.33749259316025e-09 0.421988255273135 0.0732089026211386 miRNATAP -0.204870248909093 0.00168265901828329 NA NA NA hsa-miR-148b-5p EGFR 1.1533193737265 7.26420964688337e-13 0.421988255273135 0.0732089026211386 mirMAP -0.286420865380633 5.32215159627121e-06 NA NA NA hsa-miR-155-5p EGFR 0.533437622040649 0.00248671179205372 0.421988255273135 0.0732089026211386 miRNAWalker2_validate;MirTarget -0.315457381088104 4.08354886790646e-08 NA NA NA hsa-miR-16-2-3p EGFR 1.1567130855258 1.01867256952189e-14 0.421988255273135 0.0732089026211386 mirMAP -0.358641825525018 6.42478479617906e-08 NA NA NA hsa-miR-16-5p EGFR 0.521122945828175 1.40561786410572e-06 0.421988255273135 0.0732089026211386 miRNAWalker2_validate -0.328580412453127 0.000519061828104517 NA NA NA hsa-miR-17-5p EGFR 1.41924888736771 2.75805544953758e-18 0.421988255273135 0.0732089026211386 TargetScan -0.226636907400546 0.000196756202717447 NA NA NA hsa-miR-186-5p EGFR 0.353452958261612 0.000145058448579496 0.421988255273135 0.0732089026211386 mirMAP -0.576889529374807 1.57349391573345e-07 NA NA NA hsa-miR-188-5p EGFR 0.559328953885106 0.000430338888594543 0.421988255273135 0.0732089026211386 mirMAP -0.24946956675347 0.000110017792853201 NA NA NA hsa-miR-192-5p EGFR 0.380924502586635 0.00986961967409205 0.421988255273135 0.0732089026211386 mirMAP -0.285652307836721 3.76566486689093e-05 NA NA NA hsa-miR-194-3p EGFR 0.735945243226384 8.65425299041628e-05 0.421988255273135 0.0732089026211386 MirTarget -0.203346613744587 0.000253896402950562 NA NA NA hsa-miR-195-3p EGFR -0.624259620429699 0.000164279659144497 0.421988255273135 0.0732089026211386 mirMAP -0.19497730351888 0.00166149772991568 24282590 Plasma levels of miR-195 and miR-122 expression were also associated with overall survival in the patients especially in those with advanced stage HR=0.23 95%CI:0.07-0.84; and HR=0.22 95%CI:0.06-0.77 and EGFR mutation HR=0.27 95%CI:0.08-0.96; and HR=0.23 95%CI=0.06-0.81; Circulating miR-195 and miR-122 may have prognostic values in predicting the overall survival as well as predicting EGFR mutation status in non-smoking female patients with lung adenocarcinoma; Measuring plasma levels of miR-195 and miR-122 may especially be useful in EGFR mutant patients with lung adenocarcinoma staging;poor survival lung cancer hsa-miR-19b-1-5p EGFR 0.757034032029085 2.99828133413343e-07 0.421988255273135 0.0732089026211386 MirTarget;mirMAP -0.264619317805959 0.000116525502311464 NA NA NA hsa-miR-200a-3p EGFR 0.607140814457753 0.00289840524858752 0.421988255273135 0.0732089026211386 MirTarget -0.185851016039293 0.0002060718259245 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-29a-5p EGFR 0.323252792625584 0.0370417231222825 0.421988255273135 0.0732089026211386 mirMAP -0.315796770084768 1.62274156486412e-06 27477273 Feedback Loop Regulation of SCAP/SREBP 1 by miR 29 Modulates EGFR Signaling Driven Glioblastoma Growth glioblastoma hsa-miR-29b-1-5p EGFR 1.39669186711325 4.36960953138935e-11 0.421988255273135 0.0732089026211386 mirMAP -0.139979215565319 0.00326868198559164 NA NA NA hsa-miR-29b-2-5p EGFR -0.502720326849742 0.000730448246894952 0.421988255273135 0.0732089026211386 mirMAP -0.497369532233757 1.56245540377723e-13 NA NA NA hsa-miR-30a-5p EGFR -1.79779915425811 1.93360169837799e-26 0.421988255273135 0.0732089026211386 miRNAWalker2_validate -0.306757641684714 8.20602294984162e-08 NA NA NA hsa-miR-30d-3p EGFR -0.577371911152798 2.02950840095287e-06 0.421988255273135 0.0732089026211386 mirMAP -0.55614047964665 1.90273921147636e-11 NA NA NA hsa-miR-320a EGFR 0.801356001806321 4.91397101474502e-09 0.421988255273135 0.0732089026211386 miRanda;mirMAP -0.4112815999507 1.99503458536141e-08 NA NA NA hsa-miR-339-5p EGFR 1.07771430326938 2.45772601859307e-09 0.421988255273135 0.0732089026211386 miRanda -0.301182089829907 5.46692321863833e-08 NA NA NA hsa-miR-342-3p EGFR 0.99756868977753 9.28499866272332e-10 0.421988255273135 0.0732089026211386 miRanda -0.470164440540375 8.18136541285207e-15 NA NA NA hsa-miR-362-5p EGFR 0.41089772861323 0.0404254902071382 0.421988255273135 0.0732089026211386 mirMAP -0.490166529371809 1.47272058402061e-23 NA NA NA hsa-miR-374a-3p EGFR -0.299190081500425 0.00682975596757891 0.421988255273135 0.0732089026211386 mirMAP -0.471337447459554 3.48991327357632e-07 NA NA NA hsa-miR-491-5p EGFR -0.541680329196715 0.00135829217561865 0.421988255273135 0.0732089026211386 miRanda -0.223393265101076 0.000416870423604875 25299770 This latter effect is due to direct targeting of epidermal growth factor receptor EGFR by miR-491-5p and consequent inhibition of downstream AKT and MAPK signalling pathways; Induction of apoptosis by miR-491-5p in this cell line is mimicked by a combination of EGFR inhibition together with a BH3-mimetic molecule ovarian cancer hsa-miR-501-5p EGFR 1.02806906860218 1.63456814370548e-09 0.421988255273135 0.0732089026211386 mirMAP -0.286508470352779 1.61039937416558e-06 NA NA NA hsa-miR-590-3p EGFR 0.221436901462551 0.0965904764063157 0.421988255273135 0.0732089026211386 mirMAP -0.316063504281599 4.07580543518307e-05 NA NA NA hsa-miR-590-5p EGFR 0.763025362395968 3.65305892505623e-09 0.421988255273135 0.0732089026211386 miRanda;mirMAP -0.335383582937528 1.76757509066129e-05 NA NA NA hsa-miR-7-1-3p EGFR 1.13646121619622 1.49823237535933e-14 0.421988255273135 0.0732089026211386 mirMAP -0.275683965863029 4.44815829786658e-05 NA NA NA hsa-miR-9-5p EGFR 1.65694862043766 2.08325802567323e-05 0.421988255273135 0.0732089026211386 mirMAP -0.148975590966979 7.78083247312223e-09 23365639 We elected to validate our model in vitro by testing the effects of EGFR inhibition on downstream MYC miR-9 and let-7a expression; Our mathematical model explains the signaling link among EGFR MYC and miR-9 but not let-7 lung cancer hsa-miR-125a-5p EPHA2 0.215366061934933 0.119550904549401 -0.89230286460788 3.16570714720682e-07 miRanda -0.210671640733579 0.000151019599935608 NA NA NA hsa-miR-708-3p EPHA2 1.32647174389322 4.87465491977979e-16 -0.89230286460788 3.16570714720682e-07 MirTarget -0.145771609712637 0.00141205535253872 NA NA NA hsa-miR-1180-3p ETS1 0.978385392321663 1.89039300896175e-08 0.843184345784366 2.18979094916684e-07 MirTarget -0.156297437302618 0.000115335290916698 NA NA NA hsa-miR-141-3p ETS1 0.730011517758706 0.000120338355004032 0.843184345784366 2.18979094916684e-07 mirMAP -0.362915016394396 5.48247759659359e-24 NA NA NA hsa-miR-141-5p ETS1 0.623874471326586 0.0018690552472983 0.843184345784366 2.18979094916684e-07 mirMAP -0.2369501129177 1.25771006769223e-11 NA NA NA hsa-miR-148b-5p ETS1 1.1533193737265 7.26420964688337e-13 0.843184345784366 2.18979094916684e-07 MirTarget -0.137735331487554 0.00181598654167541 NA NA NA hsa-miR-16-1-3p ETS1 0.955017760172879 5.95379292601146e-11 0.843184345784366 2.18979094916684e-07 MirTarget -0.135643457195514 0.00510091183366702 NA NA NA hsa-miR-199b-5p ETS1 -1.08432682485992 7.68241801134089e-10 0.843184345784366 2.18979094916684e-07 MirTarget;PITA;miRanda;miRNATAP -0.16743719272457 2.64386824706811e-05 NA NA NA hsa-miR-200a-3p ETS1 0.607140814457753 0.00289840524858752 0.843184345784366 2.18979094916684e-07 mirMAP -0.364431194522309 6.12813284974314e-28 NA NA NA hsa-miR-200b-3p ETS1 0.0717138787925347 0.682858087587209 0.843184345784366 2.18979094916684e-07 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.426148765030991 4.92383963052204e-28 NA NA NA hsa-miR-200c-3p ETS1 0.630251054099546 0.000131975031451555 0.843184345784366 2.18979094916684e-07 MirTarget;miRNATAP -0.296027291662379 3.1677408759464e-12 NA NA NA hsa-miR-23b-3p ETS1 -0.497563803223134 3.31483353357535e-05 0.843184345784366 2.18979094916684e-07 mirMAP -0.231320992936979 0.000101807651856278 NA NA NA hsa-miR-27b-5p ETS1 0.580870079022649 0.000181529223377382 0.843184345784366 2.18979094916684e-07 MirTarget;miRNATAP -0.257938031998281 1.45692701791105e-08 NA NA NA hsa-miR-30c-5p ETS1 0.021222006155897 0.886366656528128 0.843184345784366 2.18979094916684e-07 miRNAWalker2_validate -0.289669529716373 1.36119793996392e-09 NA NA NA hsa-miR-30d-3p ETS1 -0.577371911152798 2.02950840095287e-06 0.843184345784366 2.18979094916684e-07 mirMAP -0.387122482132789 2.19257157697381e-11 NA NA NA hsa-miR-335-3p ETS1 0.336785882180547 0.0542446207938138 0.843184345784366 2.18979094916684e-07 mirMAP -0.218088256896 7.71614462461208e-08 NA NA NA hsa-miR-338-3p ETS1 -0.948755228846395 8.99167125682392e-08 0.843184345784366 2.18979094916684e-07 MirTarget;PITA;miRanda;miRNATAP -0.174816084353312 1.07434534590851e-05 NA NA NA hsa-miR-3607-3p ETS1 1.01377165357363 9.13355519701165e-05 0.843184345784366 2.18979094916684e-07 mirMAP -0.106759324697244 9.75741441603499e-05 NA NA NA hsa-miR-362-3p ETS1 -0.697212068252854 2.61718493418184e-06 0.843184345784366 2.18979094916684e-07 miRanda -0.158637704345521 0.000979082462677013 NA NA NA hsa-miR-429 ETS1 0.559451508722375 0.00563641638673083 0.843184345784366 2.18979094916684e-07 MirTarget;PITA;miRanda;miRNATAP -0.360117341147822 1.01685609282722e-26 NA NA NA hsa-miR-501-5p ETS1 1.02806906860218 1.63456814370548e-09 0.843184345784366 2.18979094916684e-07 mirMAP -0.120818265598148 0.00401256958979923 NA NA NA hsa-miR-532-3p ETS1 0.80240056676907 1.08989551712617e-09 0.843184345784366 2.18979094916684e-07 MirTarget;PITA;miRNATAP -0.15140549388627 0.00488586805297234 NA NA NA hsa-miR-590-5p ETS1 0.763025362395968 3.65305892505623e-09 0.843184345784366 2.18979094916684e-07 miRanda -0.279480025847153 2.70342832342717e-07 NA NA NA hsa-miR-660-5p ETS1 -0.202705992887645 0.101093376073573 0.843184345784366 2.18979094916684e-07 MirTarget -0.395267371469129 4.81150479557563e-12 NA NA NA hsa-miR-664a-3p ETS1 -0.256108763664991 0.0513188660751664 0.843184345784366 2.18979094916684e-07 mirMAP -0.277630601903516 3.13611269913878e-07 NA NA NA hsa-miR-769-5p ETS1 0.0865819375213306 0.445395188017017 0.843184345784366 2.18979094916684e-07 miRNATAP -0.245319076636235 0.00011094924587179 NA NA NA hsa-miR-9-5p ETS1 1.65694862043766 2.08325802567323e-05 0.843184345784366 2.18979094916684e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.142003083779203 1.27564356299828e-15 NA NA NA hsa-miR-149-5p ETS2 0.443278770827687 0.0642022866136881 -0.091828822262106 0.497970729350927 miRNAWalker2_validate -0.117459766997294 1.46942448949405e-06 NA NA NA hsa-miR-182-5p ETS2 1.15060905311096 6.25565852529946e-10 -0.091828822262106 0.497970729350927 miRNATAP -0.111982203252625 0.000314705396453197 NA NA NA hsa-miR-218-5p ETS2 -1.0725338636959 3.61493686604269e-09 -0.091828822262106 0.497970729350927 miRNAWalker2_validate -0.22081643341697 1.79784273704156e-12 NA NA NA hsa-miR-320a ETS2 0.801356001806321 4.91397101474502e-09 -0.091828822262106 0.497970729350927 miRanda;miRNATAP -0.115296927877125 0.00672534576971126 NA NA NA hsa-let-7e-5p FASLG 0.0857356192778891 0.512869729833211 0.394703525705912 0.21882393973136 miRNATAP -0.353388568642215 0.000974735688504158 NA NA NA hsa-miR-199a-5p FASLG -0.364835768178638 0.0435119211101981 0.394703525705912 0.21882393973136 miRanda -0.273318512204072 0.000400614015733864 NA NA NA hsa-miR-452-3p FASLG 1.09618110917892 2.21867884261816e-07 0.394703525705912 0.21882393973136 mirMAP -0.298192608882689 4.3334365675638e-06 NA NA NA hsa-miR-18a-5p FGF1 1.65455873230328 3.76457892277775e-20 -0.258011343667108 0.26760431731263 MirTarget -0.277496437672487 2.43959718026235e-07 NA NA NA hsa-miR-193a-3p FGF1 0.22120710726779 0.111827069464729 -0.258011343667108 0.26760431731263 PITA -0.202240172681954 0.00567870004542482 NA NA NA hsa-miR-205-5p FGF1 1.50759485376634 2.0003886738248e-16 -0.258011343667108 0.26760431731263 mirMAP -0.198163178508369 0.000211883664826537 NA NA NA hsa-miR-2355-5p FGF1 1.47205546931107 8.65192179636668e-19 -0.258011343667108 0.26760431731263 MirTarget -0.185602955162296 0.00160680328845676 NA NA NA hsa-miR-484 FGF1 0.918280909791707 1.39168306854263e-14 -0.258011343667108 0.26760431731263 MirTarget;PITA;miRNATAP -0.389291918702885 2.4520525029842e-06 NA NA NA hsa-miR-532-3p FGF1 0.80240056676907 1.08989551712617e-09 -0.258011343667108 0.26760431731263 miRNATAP -0.216024621372653 0.004507077796501 NA NA NA hsa-miR-576-5p FGF1 0.940432050128373 6.90227595663302e-12 -0.258011343667108 0.26760431731263 PITA;mirMAP -0.292914912309583 5.16069042343911e-05 NA NA NA hsa-miR-590-5p FGF1 0.763025362395968 3.65305892505623e-09 -0.258011343667108 0.26760431731263 MirTarget;miRanda;miRNATAP -0.317241137495249 3.95390401682399e-05 NA NA NA hsa-miR-629-5p FGF1 0.461215538037447 8.95262667860215e-06 -0.258011343667108 0.26760431731263 MirTarget -0.658892526979509 6.2109593316048e-12 NA NA NA hsa-miR-944 FGF1 1.47323925060177 2.61626403984929e-13 -0.258011343667108 0.26760431731263 mirMAP -0.319683604411362 3.57117911228316e-11 NA NA NA hsa-let-7f-5p FGF11 -0.441845198213823 0.00242957484218694 0.817619191220799 0.000125130498795574 mirMAP;miRNATAP -0.252953039973085 7.44143657639289e-05 NA NA NA hsa-let-7g-5p FGF11 -0.250780249469264 0.00939610188330072 0.817619191220799 0.000125130498795574 mirMAP;miRNATAP -0.370971716833525 0.000137291311349804 NA NA NA hsa-miR-125b-5p FGF11 -0.993460109818276 5.07736727659894e-12 0.817619191220799 0.000125130498795574 mirMAP -0.24169989978906 0.000142160166852154 NA NA NA hsa-miR-181c-5p FGF11 -0.168991199007857 0.196949106150297 0.817619191220799 0.000125130498795574 mirMAP -0.20614633962775 0.00401693406111408 NA NA NA hsa-miR-195-5p FGF11 -1.8367376818177 6.9944883988895e-31 0.817619191220799 0.000125130498795574 mirMAP -0.198302055931528 0.000331638911045397 NA NA NA hsa-miR-217 FGF11 -1.35391381055929 2.42394951427902e-09 0.817619191220799 0.000125130498795574 PITA;miRanda -0.10449304001688 0.0099270377926623 NA NA NA hsa-miR-221-5p FGF11 -0.53190793287441 0.0379158336541952 0.817619191220799 0.000125130498795574 miRNATAP -0.119704813324824 0.000984850545712735 NA NA NA hsa-miR-28-5p FGF11 -0.026996999089909 0.733047113251652 0.817619191220799 0.000125130498795574 miRanda -0.404088723713172 0.000764907597908066 NA NA NA hsa-miR-326 FGF11 -0.425943992128769 0.0415010315530797 0.817619191220799 0.000125130498795574 MirTarget;PITA;miRanda;miRNATAP -0.205709585070413 3.91411336469149e-06 NA NA NA hsa-miR-628-5p FGF11 -0.554239048796013 4.92386883216087e-05 0.817619191220799 0.000125130498795574 miRNATAP -0.361198975570433 8.93992785542876e-08 NA NA NA hsa-miR-142-5p FGF12 0.288897753038094 0.0900009317815725 -0.582614717688515 0.0551727720869136 miRNATAP -0.329957050688491 2.05218174125255e-05 NA NA NA hsa-miR-205-3p FGF12 1.2960640797621 5.80786479909147e-11 -0.582614717688515 0.0551727720869136 MirTarget -0.272629135698617 3.0622926253504e-05 NA NA NA hsa-miR-2355-3p FGF12 1.58434563546762 4.06578912176206e-18 -0.582614717688515 0.0551727720869136 MirTarget;miRNATAP -0.38448285919751 3.04446467725463e-08 NA NA NA hsa-miR-29a-5p FGF12 0.323252792625584 0.0370417231222825 -0.582614717688515 0.0551727720869136 MirTarget -0.38111533263344 7.52153613120094e-06 NA NA NA hsa-miR-342-3p FGF12 0.99756868977753 9.28499866272332e-10 -0.582614717688515 0.0551727720869136 miRanda -0.340856513705552 1.90111712777334e-05 NA NA NA hsa-miR-450b-5p FGF12 1.25529820885833 1.18847120528666e-15 -0.582614717688515 0.0551727720869136 miRNATAP -0.237099192523695 0.00393637076050291 NA NA NA hsa-miR-455-5p FGF12 1.408595672323 5.52039116456697e-22 -0.582614717688515 0.0551727720869136 miRanda -0.551210175951459 1.29665519180675e-10 NA NA NA hsa-miR-511-5p FGF12 0.214339847118675 0.232372953100021 -0.582614717688515 0.0551727720869136 MirTarget -0.232230880342727 0.00166625415209001 NA NA NA hsa-miR-542-3p FGF12 0.643308814904977 8.81635403230104e-07 -0.582614717688515 0.0551727720869136 miRanda -0.329632103105734 0.00104162237655472 NA NA NA hsa-miR-576-5p FGF12 0.940432050128373 6.90227595663302e-12 -0.582614717688515 0.0551727720869136 mirMAP -0.408242189119232 1.55698433321357e-05 NA NA NA hsa-let-7b-3p FGF13 0.120166961637302 0.299224004314356 -1.46301246813209 1.10281013324847e-05 MirTarget;miRNATAP -0.395582167462648 0.00186130582510831 NA NA NA hsa-let-7f-1-3p FGF13 0.700374242293247 8.65000484720084e-08 -1.46301246813209 1.10281013324847e-05 MirTarget -0.413328586300836 0.000184731392195485 NA NA NA hsa-miR-141-3p FGF13 0.730011517758706 0.000120338355004032 -1.46301246813209 1.10281013324847e-05 TargetScan -0.217008682104236 0.00461729582654458 NA NA NA hsa-miR-142-5p FGF13 0.288897753038094 0.0900009317815725 -1.46301246813209 1.10281013324847e-05 PITA -0.257065161129666 0.00275687664306998 NA NA NA hsa-miR-31-3p FGF13 2.10124531535908 1.70135756565194e-08 -1.46301246813209 1.10281013324847e-05 miRNATAP -0.318757205751666 1.9138000549862e-17 NA NA NA hsa-miR-3682-3p FGF13 0.707626231028898 1.50609185515014e-05 -1.46301246813209 1.10281013324847e-05 MirTarget -0.251232120368971 0.00488545679786259 NA NA NA hsa-miR-455-5p FGF13 1.408595672323 5.52039116456697e-22 -1.46301246813209 1.10281013324847e-05 PITA;miRanda -0.744922261520023 1.82247837214577e-15 NA NA NA hsa-miR-7-1-3p FGF13 1.13646121619622 1.49823237535933e-14 -1.46301246813209 1.10281013324847e-05 MirTarget;mirMAP -0.347115115224032 0.000314178039831248 NA NA NA hsa-miR-193a-5p FGF14 0.351460703308937 0.00347717541215117 -1.62704249037492 1.3148897101317e-07 TargetScan -0.406581901327017 0.0003265222795513 NA NA NA hsa-miR-590-3p FGF14 0.221436901462551 0.0965904764063157 -1.62704249037492 1.3148897101317e-07 miRanda -0.42830851823148 2.68300448941013e-05 NA NA NA hsa-miR-96-5p FGF14 1.42326703011157 4.39736150032373e-14 -1.62704249037492 1.3148897101317e-07 TargetScan -0.337834021759798 1.31045376791808e-06 NA NA NA hsa-miR-103a-3p FGF18 0.556219385347418 1.55815736455067e-09 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.496370794423683 0.000332281911081466 NA NA NA hsa-miR-15a-5p FGF18 0.783550182002274 2.60699595655907e-11 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.702693009108968 3.09754498733063e-11 NA NA NA hsa-miR-15b-5p FGF18 0.85315666454713 3.79816274836297e-12 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.546279443338623 7.76425760723514e-08 NA NA NA hsa-miR-16-5p FGF18 0.521122945828175 1.40561786410572e-06 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.634380188554347 6.35545983795006e-08 NA NA NA hsa-miR-200b-3p FGF18 0.0717138787925347 0.682858087587209 -1.88786711762185 6.1965148779705e-11 TargetScan -0.338800867319404 3.20904303944546e-06 NA NA NA hsa-miR-200c-3p FGF18 0.630251054099546 0.000131975031451555 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.491042406920311 1.19246477608829e-10 NA NA NA hsa-miR-21-5p FGF18 1.62465922021121 3.44191300985109e-58 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.522565820217367 3.80501286581297e-06 NA NA NA hsa-miR-330-5p FGF18 0.944693925383906 5.04972895657346e-13 -1.88786711762185 6.1965148779705e-11 PITA;miRanda;miRNATAP -0.364911036381969 0.000141889829673744 NA NA NA hsa-miR-424-5p FGF18 1.48125289532143 9.10372985713165e-19 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.411226086316741 1.91859919749703e-08 NA NA NA hsa-miR-429 FGF18 0.559451508722375 0.00563641638673083 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.383425444613611 8.10623231086834e-10 NA NA NA hsa-miR-505-3p FGF18 0.912823669571645 4.0549774967148e-13 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.45816431477501 4.02225324767235e-06 NA NA NA hsa-miR-590-5p FGF18 0.763025362395968 3.65305892505623e-09 -1.88786711762185 6.1965148779705e-11 miRanda;miRNATAP -0.628733840517059 7.22877221668898e-11 NA NA NA hsa-miR-193a-3p FGF19 0.22120710726779 0.111827069464729 1.92934227956647 8.15438676803874e-05 miRanda -0.541295534008293 0.000464328018223873 NA NA NA hsa-let-7a-3p FGF2 0.0966652362351867 0.423761916840503 -0.873895268607156 0.000749629544409884 mirMAP -0.346697326213815 0.000235155196874588 NA NA NA hsa-miR-15a-5p FGF2 0.783550182002274 2.60699595655907e-11 -0.873895268607156 0.000749629544409884 MirTarget;miRNATAP -0.337568241456238 0.000380629759701841 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 0.955017760172879 5.95379292601146e-11 -0.873895268607156 0.000749629544409884 mirMAP -0.216053774665656 0.00482669676692554 NA NA NA hsa-miR-19b-1-5p FGF2 0.757034032029085 2.99828133413343e-07 -0.873895268607156 0.000749629544409884 mirMAP -0.299411866060348 7.91846938731196e-05 NA NA NA hsa-miR-20a-3p FGF2 1.34885093664027 2.07697464119202e-12 -0.873895268607156 0.000749629544409884 mirMAP -0.254686140332496 9.5611184793422e-06 NA NA NA hsa-miR-21-3p FGF2 1.25126438776674 2.4124216716282e-17 -0.873895268607156 0.000749629544409884 mirMAP -0.32497551048351 1.17275178306699e-05 NA NA NA hsa-miR-21-5p FGF2 1.62465922021121 3.44191300985109e-58 -0.873895268607156 0.000749629544409884 mirMAP -0.383531284677615 0.000132348473852467 NA NA NA hsa-miR-221-3p FGF2 0.410625614724387 0.000741090075261272 -0.873895268607156 0.000749629544409884 mirMAP -0.449825295563516 1.20603425503909e-06 NA NA NA hsa-miR-222-3p FGF2 1.08197052578759 2.32604040301699e-14 -0.873895268607156 0.000749629544409884 mirMAP -0.480077702405072 4.64663204454521e-10 NA NA NA hsa-miR-424-5p FGF2 1.48125289532143 9.10372985713165e-19 -0.873895268607156 0.000749629544409884 MirTarget;miRNATAP -0.246395124820535 0.000160269078978561 NA NA NA hsa-miR-429 FGF2 0.559451508722375 0.00563641638673083 -0.873895268607156 0.000749629544409884 mirMAP -0.179751399599829 0.00131313676812878 NA NA NA hsa-miR-450b-5p FGF2 1.25529820885833 1.18847120528666e-15 -0.873895268607156 0.000749629544409884 mirMAP -0.227108898055622 0.001244749731088 NA NA NA hsa-miR-452-5p FGF2 0.373288744398455 0.0348485937209964 -0.873895268607156 0.000749629544409884 mirMAP -0.346192872192568 4.93639730457593e-08 NA NA NA hsa-miR-503-5p FGF2 2.85210590411715 1.27298190263569e-35 -0.873895268607156 0.000749629544409884 miRNAWalker2_validate -0.222158187558667 3.87633414352609e-06 NA NA NA hsa-miR-589-3p FGF2 1.59559692667315 6.2886410639161e-15 -0.873895268607156 0.000749629544409884 mirMAP -0.162744204065903 0.00378641086950463 NA NA NA hsa-miR-590-5p FGF2 0.763025362395968 3.65305892505623e-09 -0.873895268607156 0.000749629544409884 miRanda;mirMAP -0.362188154730295 2.75175904757516e-05 NA NA NA hsa-miR-92a-3p FGF2 0.994679542307232 1.32587679156217e-16 -0.873895268607156 0.000749629544409884 miRNAWalker2_validate -0.350572454919679 0.000131198641822221 NA NA NA hsa-miR-944 FGF2 1.47323925060177 2.61626403984929e-13 -0.873895268607156 0.000749629544409884 MirTarget -0.297247292575655 4.68482644368958e-08 NA NA NA hsa-miR-155-5p FGF5 0.533437622040649 0.00248671179205372 2.03532963351149 1.96791908743617e-07 mirMAP -0.31284053064953 0.00133764239981059 NA NA NA hsa-miR-15b-5p FGF5 0.85315666454713 3.79816274836297e-12 2.03532963351149 1.96791908743617e-07 miRNAWalker2_validate -0.539510689376273 8.89932041304568e-05 NA NA NA hsa-miR-16-1-3p FGF5 0.955017760172879 5.95379292601146e-11 2.03532963351149 1.96791908743617e-07 mirMAP -0.435673839937129 0.000178123016562154 NA NA NA hsa-miR-30b-5p FGF5 -0.400238605368173 0.00346540992719245 2.03532963351149 1.96791908743617e-07 mirMAP -0.584264957941181 3.11677593098393e-06 NA NA NA hsa-miR-30c-5p FGF5 0.021222006155897 0.886366656528128 2.03532963351149 1.96791908743617e-07 mirMAP -0.414523178107725 0.000368274960248606 NA NA NA hsa-miR-30d-5p FGF5 -0.38399848121878 0.000171129616944749 2.03532963351149 1.96791908743617e-07 mirMAP -0.830892592830511 7.77553120763636e-07 NA NA NA hsa-miR-30e-5p FGF5 -1.02114836019762 6.81961221797866e-17 2.03532963351149 1.96791908743617e-07 mirMAP -1.010076240996 5.35877622269213e-14 NA NA NA hsa-miR-33a-3p FGF5 0.20371038027126 0.212335697664505 2.03532963351149 1.96791908743617e-07 mirMAP -0.564415390474596 1.13151442887737e-07 NA NA NA hsa-miR-3607-3p FGF5 1.01377165357363 9.13355519701165e-05 2.03532963351149 1.96791908743617e-07 miRNATAP -0.243752423074476 0.000221294949256888 NA NA NA hsa-miR-374a-5p FGF5 -0.621903385111545 6.61791773205282e-12 2.03532963351149 1.96791908743617e-07 mirMAP -0.578953744206145 0.00214972210165144 NA NA NA hsa-miR-374b-5p FGF5 -0.288413933608091 0.0041474558664058 2.03532963351149 1.96791908743617e-07 mirMAP -0.460448246804867 0.00769448722291093 NA NA NA hsa-miR-582-5p FGF5 -0.0366995972742474 0.821827119138923 2.03532963351149 1.96791908743617e-07 mirMAP -0.438895718657925 3.30028681894977e-05 NA NA NA hsa-miR-7-1-3p FGF5 1.13646121619622 1.49823237535933e-14 2.03532963351149 1.96791908743617e-07 mirMAP -0.491319043524203 1.46162304642574e-05 NA NA NA hsa-miR-9-5p FGF5 1.65694862043766 2.08325802567323e-05 2.03532963351149 1.96791908743617e-07 mirMAP;miRNATAP -0.319095858366486 1.04359689832769e-13 NA NA NA hsa-let-7a-3p FGF7 0.0966652362351867 0.423761916840503 -2.01548136096491 3.47916106415079e-16 MirTarget;miRNATAP -0.407412421508281 9.39576644959233e-06 NA NA NA hsa-miR-15a-5p FGF7 0.783550182002274 2.60699595655907e-11 -2.01548136096491 3.47916106415079e-16 miRTarBase;miRNATAP -0.758176143394721 5.17214837920814e-17 NA NA NA hsa-miR-15b-5p FGF7 0.85315666454713 3.79816274836297e-12 -2.01548136096491 3.47916106415079e-16 miRNATAP -0.568341530637 8.06625251176299e-11 NA NA NA hsa-miR-16-1-3p FGF7 0.955017760172879 5.95379292601146e-11 -2.01548136096491 3.47916106415079e-16 mirMAP -0.582550949106155 1.52037236233235e-15 NA NA NA hsa-miR-16-2-3p FGF7 1.1567130855258 1.01867256952189e-14 -2.01548136096491 3.47916106415079e-16 mirMAP -0.662388065162359 1.98377986171799e-21 NA NA NA hsa-miR-16-5p FGF7 0.521122945828175 1.40561786410572e-06 -2.01548136096491 3.47916106415079e-16 miRNATAP -0.528266917563882 2.01078150816863e-07 NA NA NA hsa-miR-18a-3p FGF7 1.82583720936229 7.51297960972179e-19 -2.01548136096491 3.47916106415079e-16 MirTarget -0.46844558781355 1.08349793094373e-19 NA NA NA hsa-miR-205-3p FGF7 1.2960640797621 5.80786479909147e-11 -2.01548136096491 3.47916106415079e-16 mirMAP -0.547481712642976 1.77873769265097e-25 NA NA NA hsa-miR-20a-5p FGF7 1.1531986665452 1.02385132917958e-11 -2.01548136096491 3.47916106415079e-16 miRNAWalker2_validate -0.613419630660297 2.02970970138624e-23 NA NA NA hsa-miR-27a-3p FGF7 0.348456440505425 0.00126682892514312 -2.01548136096491 3.47916106415079e-16 MirTarget -0.485890878724566 2.08331319035218e-06 NA NA NA hsa-miR-31-5p FGF7 2.79079137807505 1.72181058015659e-13 -2.01548136096491 3.47916106415079e-16 MirTarget -0.251497031870126 2.0735964251059e-19 NA NA NA hsa-miR-320a FGF7 0.801356001806321 4.91397101474502e-09 -2.01548136096491 3.47916106415079e-16 miRanda -0.344732081653175 1.52541649148947e-05 NA NA NA hsa-miR-320b FGF7 1.23473838180754 3.04337566045537e-14 -2.01548136096491 3.47916106415079e-16 miRanda -0.306922120859187 3.56854180676285e-06 NA NA NA hsa-miR-33a-3p FGF7 0.20371038027126 0.212335697664505 -2.01548136096491 3.47916106415079e-16 mirMAP -0.267156731589519 0.000105178848642306 NA NA NA hsa-miR-3607-3p FGF7 1.01377165357363 9.13355519701165e-05 -2.01548136096491 3.47916106415079e-16 mirMAP -0.231628164127034 3.82613094762849e-08 NA NA NA hsa-miR-424-5p FGF7 1.48125289532143 9.10372985713165e-19 -2.01548136096491 3.47916106415079e-16 miRNATAP -0.320726779959208 4.43814875864373e-07 NA NA NA hsa-miR-429 FGF7 0.559451508722375 0.00563641638673083 -2.01548136096491 3.47916106415079e-16 miRNATAP -0.456460483342231 8.35745432718304e-18 NA NA NA hsa-miR-452-5p FGF7 0.373288744398455 0.0348485937209964 -2.01548136096491 3.47916106415079e-16 mirMAP -0.295494838128618 2.11954883967322e-06 NA NA NA hsa-miR-455-3p FGF7 2.68574446868387 4.28975903022818e-42 -2.01548136096491 3.47916106415079e-16 PITA;miRNATAP -0.510499869886505 3.92708976432283e-25 NA NA NA hsa-miR-484 FGF7 0.918280909791707 1.39168306854263e-14 -2.01548136096491 3.47916106415079e-16 PITA -0.553887894998084 6.92443925890007e-10 NA NA NA hsa-miR-501-5p FGF7 1.02806906860218 1.63456814370548e-09 -2.01548136096491 3.47916106415079e-16 PITA;mirMAP -0.268272897559334 3.42494201805503e-05 NA NA NA hsa-miR-590-3p FGF7 0.221436901462551 0.0965904764063157 -2.01548136096491 3.47916106415079e-16 PITA;miRanda;mirMAP;miRNATAP -0.27812954133398 0.000866348391234384 NA NA NA hsa-miR-590-5p FGF7 0.763025362395968 3.65305892505623e-09 -2.01548136096491 3.47916106415079e-16 PITA;miRanda -0.701558117453836 1.5867556887698e-17 NA NA NA hsa-miR-7-1-3p FGF7 1.13646121619622 1.49823237535933e-14 -2.01548136096491 3.47916106415079e-16 mirMAP -0.458342824311289 2.15620787170561e-10 NA NA NA hsa-miR-708-3p FGF7 1.32647174389322 4.87465491977979e-16 -2.01548136096491 3.47916106415079e-16 mirMAP -0.437698752984361 1.47737195240182e-11 NA NA NA hsa-miR-944 FGF7 1.47323925060177 2.61626403984929e-13 -2.01548136096491 3.47916106415079e-16 mirMAP -0.37225697445087 1.67116584248206e-12 NA NA NA hsa-miR-142-3p FGF9 1.12754191614028 1.68798138028946e-08 -1.38200824505352 9.05347102190895e-06 miRanda -0.259765933502149 0.000113295496265394 NA NA NA hsa-miR-15a-5p FGF9 0.783550182002274 2.60699595655907e-11 -1.38200824505352 9.05347102190895e-06 miRNATAP -0.357865605085935 0.0018124991757053 NA NA NA hsa-miR-16-2-3p FGF9 1.1567130855258 1.01867256952189e-14 -1.38200824505352 9.05347102190895e-06 mirMAP -0.375706331819685 2.36450540389056e-05 NA NA NA hsa-miR-205-5p FGF9 1.50759485376634 2.0003886738248e-16 -1.38200824505352 9.05347102190895e-06 miRNATAP -0.416585862637498 5.72993182011151e-09 NA NA NA hsa-miR-330-5p FGF9 0.944693925383906 5.04972895657346e-13 -1.38200824505352 9.05347102190895e-06 miRanda;miRNATAP -0.282467140589527 0.00592832027325082 NA NA NA hsa-miR-455-5p FGF9 1.408595672323 5.52039116456697e-22 -1.38200824505352 9.05347102190895e-06 miRanda -0.519010790529783 5.18865705861902e-09 NA NA NA hsa-miR-590-5p FGF9 0.763025362395968 3.65305892505623e-09 -1.38200824505352 9.05347102190895e-06 miRanda -0.334500927773077 0.00137367059889734 NA NA NA hsa-miR-744-3p FGF9 1.18973028739247 4.23716909078104e-10 -1.38200824505352 9.05347102190895e-06 miRNATAP -0.209668103890808 0.00297574939478547 NA NA NA hsa-miR-944 FGF9 1.47323925060177 2.61626403984929e-13 -1.38200824505352 9.05347102190895e-06 mirMAP -0.244896095804246 0.000212430618962972 NA NA NA hsa-miR-96-5p FGF9 1.42326703011157 4.39736150032373e-14 -1.38200824505352 9.05347102190895e-06 TargetScan;miRNATAP -0.191745648143166 0.00674766951778037 NA NA NA hsa-miR-106a-5p FGFR1 0.67978010057847 0.00221925869726092 -0.285304743310302 0.171119486865196 mirMAP -0.129847841479432 0.00140745214014729 NA NA NA hsa-miR-135b-5p FGFR1 1.5570143078477 4.60753610971455e-13 -0.285304743310302 0.171119486865196 mirMAP -0.281548954961466 3.25890310081625e-12 NA NA NA hsa-miR-15a-5p FGFR1 0.783550182002274 2.60699595655907e-11 -0.285304743310302 0.171119486865196 miRNATAP -0.403658939025052 8.79750014830109e-08 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 0.85315666454713 3.79816274836297e-12 -0.285304743310302 0.171119486865196 miRNATAP -0.214437670759984 0.00317282993888603 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.521122945828175 1.40561786410572e-06 -0.285304743310302 0.171119486865196 miRTarBase;miRNATAP -0.38922203488893 3.0006114587061e-06 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 1.41924888736771 2.75805544953758e-18 -0.285304743310302 0.171119486865196 mirMAP -0.338598823690165 1.88464331446601e-10 NA NA NA hsa-miR-200a-5p FGFR1 0.701063526850019 0.000188402923774663 -0.285304743310302 0.171119486865196 mirMAP -0.347565186416522 1.54236670618255e-13 NA NA NA hsa-miR-200b-5p FGFR1 0.02621402664548 0.883725338810228 -0.285304743310302 0.171119486865196 mirMAP -0.319684954127201 1.58203496685162e-10 NA NA NA hsa-miR-20a-5p FGFR1 1.1531986665452 1.02385132917958e-11 -0.285304743310302 0.171119486865196 mirMAP -0.317108473561725 9.27549337118698e-10 NA NA NA hsa-miR-2355-5p FGFR1 1.47205546931107 8.65192179636668e-19 -0.285304743310302 0.171119486865196 mirMAP -0.299822634669823 8.84769794668989e-09 NA NA NA hsa-miR-301a-3p FGFR1 2.14132004241926 4.46255413526808e-25 -0.285304743310302 0.171119486865196 mirMAP -0.169994723601377 4.35783491979539e-05 NA NA NA hsa-miR-455-5p FGFR1 1.408595672323 5.52039116456697e-22 -0.285304743310302 0.171119486865196 miRanda -0.313824859592463 1.11413040800983e-07 NA NA NA hsa-miR-590-3p FGFR1 0.221436901462551 0.0965904764063157 -0.285304743310302 0.171119486865196 miRanda;mirMAP -0.267304203534255 8.80534628406325e-05 NA NA NA hsa-miR-93-5p FGFR1 1.61042951896619 5.1280369606967e-24 -0.285304743310302 0.171119486865196 mirMAP -0.169176457028053 0.00188566230333975 NA NA NA hsa-let-7a-3p FGFR2 0.0966652362351867 0.423761916840503 -0.689192404124544 0.00027530593494015 miRNATAP -0.193564939031614 0.00509899325895667 NA NA NA hsa-miR-146b-5p FGFR2 0.917975986853978 3.33749259316025e-09 -0.689192404124544 0.00027530593494015 miRanda -0.315268061524928 1.36606510703905e-09 NA NA NA hsa-miR-186-5p FGFR2 0.353452958261612 0.000145058448579496 -0.689192404124544 0.00027530593494015 miRNAWalker2_validate -0.392401143571198 1.09634780638378e-05 NA NA NA hsa-miR-193a-3p FGFR2 0.22120710726779 0.111827069464729 -0.689192404124544 0.00027530593494015 miRanda -0.357501509299468 1.39512863622931e-09 NA NA NA hsa-miR-330-5p FGFR2 0.944693925383906 5.04972895657346e-13 -0.689192404124544 0.00027530593494015 miRanda -0.214084238420235 0.000567628023207746 NA NA NA hsa-miR-338-3p FGFR2 -0.948755228846395 8.99167125682392e-08 -0.689192404124544 0.00027530593494015 miRanda;miRNATAP -0.175050696307873 0.000145068088792403 NA NA NA hsa-miR-542-3p FGFR2 0.643308814904977 8.81635403230104e-07 -0.689192404124544 0.00027530593494015 miRanda -0.356945364566282 9.9855269919112e-09 NA NA NA hsa-miR-100-5p FGFR3 -1.85857794619369 1.248973638996e-25 0.0735667865321687 0.750912348559634 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.177527076547578 0.00100959147184781 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-337-3p FGFR3 -1.70091836051933 1.39844536073221e-13 0.0735667865321687 0.750912348559634 MirTarget -0.158736976879148 0.000197575798793529 NA NA NA hsa-miR-99b-5p FGFR3 0.44137573438014 9.0939587647735e-05 0.0735667865321687 0.750912348559634 MirTarget;miRNATAP -0.313791397643478 0.000443612699243026 22969861 miR-99b was downregulated and FGFR3 was upregulated in lung cancer patients; We demonstrated that the overexpression of miR-99b induced a reduction in FGFR3 expression and confirmed the target specificity between miR-99b and the FGFR3 3'-untranslated region by luciferase reporter assay; Taken together these results suggest that miR-99b may be a tumor suppressor through the downregulation of FGFR3 miR-99b may be a potent tumor suppressor and may be a potential therapeutic tool for patients with lung cancer lung squamous cell cancer hsa-miR-10b-5p FLT1 -0.582989331935508 4.56688330655626e-06 0.739056195142607 2.68348183147666e-07 miRNATAP -0.192188128519245 9.91761533013577e-05 NA NA NA hsa-miR-139-5p FLT1 -1.46099200329485 7.85040381494472e-22 0.739056195142607 2.68348183147666e-07 miRanda -0.11787062655249 0.00316478819500311 NA NA NA hsa-miR-155-5p FLT1 0.533437622040649 0.00248671179205372 0.739056195142607 2.68348183147666e-07 miRNAWalker2_validate;mirMAP -0.110593121592625 0.00199016890826031 NA NA NA hsa-miR-17-5p FLT1 1.41924888736771 2.75805544953758e-18 0.739056195142607 2.68348183147666e-07 MirTarget;TargetScan;miRNATAP -0.162121991393848 1.47356802980238e-05 NA NA NA hsa-miR-19a-3p FLT1 1.35800152353624 2.80940447111944e-12 0.739056195142607 2.68348183147666e-07 MirTarget -0.201798812780327 1.21924202721184e-10 NA NA NA hsa-miR-19b-3p FLT1 0.538732279378089 0.000622008277870679 0.739056195142607 2.68348183147666e-07 MirTarget -0.317725439140663 3.71017620829984e-16 NA NA NA hsa-miR-200b-3p FLT1 0.0717138787925347 0.682858087587209 0.739056195142607 2.68348183147666e-07 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.21472836717083 1.68717821914887e-09 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-200c-3p FLT1 0.630251054099546 0.000131975031451555 0.739056195142607 2.68348183147666e-07 miRNAWalker2_validate;miRTarBase;MirTarget -0.155166327420166 4.55528929071695e-05 NA NA NA hsa-miR-20a-5p FLT1 1.1531986665452 1.02385132917958e-11 0.739056195142607 2.68348183147666e-07 MirTarget;miRNATAP -0.2101141978095 6.20723911885894e-09 NA NA NA hsa-miR-22-5p FLT1 0.706731861922839 3.44318705980007e-07 0.739056195142607 2.68348183147666e-07 MirTarget -0.128868934444222 0.00442712563484919 NA NA NA hsa-miR-29a-5p FLT1 0.323252792625584 0.0370417231222825 0.739056195142607 2.68348183147666e-07 MirTarget -0.196605828184586 1.25614350546622e-06 NA NA NA hsa-miR-338-3p FLT1 -0.948755228846395 8.99167125682392e-08 0.739056195142607 2.68348183147666e-07 miRanda -0.23083752446508 2.65782382187301e-11 NA NA NA hsa-miR-339-5p FLT1 1.07771430326938 2.45772601859307e-09 0.739056195142607 2.68348183147666e-07 miRanda -0.210575720734462 5.88314950670275e-10 NA NA NA hsa-miR-429 FLT1 0.559451508722375 0.00563641638673083 0.739056195142607 2.68348183147666e-07 MirTarget;miRanda;miRNATAP -0.197816271100719 1.22507430866117e-10 NA NA NA hsa-miR-576-5p FLT1 0.940432050128373 6.90227595663302e-12 0.739056195142607 2.68348183147666e-07 mirMAP -0.138330160162659 0.00226939258205763 NA NA NA hsa-miR-590-3p FLT1 0.221436901462551 0.0965904764063157 0.739056195142607 2.68348183147666e-07 miRanda -0.175486366281917 0.000222722325309575 NA NA NA hsa-miR-93-5p FLT1 1.61042951896619 5.1280369606967e-24 0.739056195142607 2.68348183147666e-07 MirTarget;miRNATAP -0.100635677473224 0.00805288617306077 NA NA NA hsa-miR-429 FLT4 0.559451508722375 0.00563641638673083 0.430026618879815 0.0189031619744705 miRanda;miRNATAP -0.322758344483548 3.44738607527909e-17 NA NA NA hsa-miR-2355-5p FOXO4 1.47205546931107 8.65192179636668e-19 -1.14676571878029 4.76610293449356e-23 MirTarget -0.304724108067146 2.0545346796384e-25 NA NA NA hsa-miR-339-5p FOXO4 1.07771430326938 2.45772601859307e-09 -1.14676571878029 4.76610293449356e-23 miRanda -0.155176583834428 5.08844714114195e-08 NA NA NA hsa-miR-484 FOXO4 0.918280909791707 1.39168306854263e-14 -1.14676571878029 4.76610293449356e-23 miRNATAP -0.14550327581795 0.000766807826257335 NA NA NA hsa-miR-590-5p FOXO4 0.763025362395968 3.65305892505623e-09 -1.14676571878029 4.76610293449356e-23 miRanda -0.14245440636316 0.000405115247949455 NA NA NA hsa-miR-96-5p FOXO4 1.42326703011157 4.39736150032373e-14 -1.14676571878029 4.76610293449356e-23 MirTarget;TargetScan;miRNATAP -0.102131406489026 0.000174991937912766 NA NA NA hsa-let-7a-3p GAB1 0.0966652362351867 0.423761916840503 -0.831915995743376 3.76673378654882e-11 mirMAP -0.189104256794753 4.44461555637458e-05 NA NA NA hsa-let-7f-1-3p GAB1 0.700374242293247 8.65000484720084e-08 -0.831915995743376 3.76673378654882e-11 mirMAP -0.126529550099057 0.00278343596237108 NA NA NA hsa-miR-106a-5p GAB1 0.67978010057847 0.00221925869726092 -0.831915995743376 3.76673378654882e-11 MirTarget;miRNATAP -0.12209969261632 8.84050686244612e-07 NA NA NA hsa-miR-106b-5p GAB1 0.50378717276868 1.45412404526866e-05 -0.831915995743376 3.76673378654882e-11 MirTarget;miRNATAP -0.316727369834914 1.83107133211524e-11 NA NA NA hsa-miR-141-3p GAB1 0.730011517758706 0.000120338355004032 -0.831915995743376 3.76673378654882e-11 MirTarget;TargetScan -0.146319385447517 4.55844036974622e-07 NA NA NA hsa-miR-141-5p GAB1 0.623874471326586 0.0018690552472983 -0.831915995743376 3.76673378654882e-11 MirTarget -0.110425308306844 6.44823470577014e-05 NA NA NA hsa-miR-15b-3p GAB1 1.05020782493504 6.38723677324836e-14 -0.831915995743376 3.76673378654882e-11 mirMAP -0.227357604590417 3.52616942838023e-09 NA NA NA hsa-miR-16-1-3p GAB1 0.955017760172879 5.95379292601146e-11 -0.831915995743376 3.76673378654882e-11 mirMAP -0.257140080995781 3.68186700353593e-12 NA NA NA hsa-miR-17-5p GAB1 1.41924888736771 2.75805544953758e-18 -0.831915995743376 3.76673378654882e-11 MirTarget;TargetScan;miRNATAP -0.216683909436252 3.11190449932723e-11 NA NA NA hsa-miR-181d-5p GAB1 0.367649966373544 0.00537300571455306 -0.831915995743376 3.76673378654882e-11 miRNAWalker2_validate -0.184426857038198 1.19575049427622e-05 NA NA NA hsa-miR-186-5p GAB1 0.353452958261612 0.000145058448579496 -0.831915995743376 3.76673378654882e-11 mirMAP -0.307783987485782 2.71046928688972e-07 NA NA NA hsa-miR-18a-5p GAB1 1.65455873230328 3.76457892277775e-20 -0.831915995743376 3.76673378654882e-11 MirTarget;miRNATAP -0.193912804218146 4.06781236263566e-11 NA NA NA hsa-miR-200a-3p GAB1 0.607140814457753 0.00289840524858752 -0.831915995743376 3.76673378654882e-11 MirTarget -0.14670086187239 5.69234712533743e-08 NA NA NA hsa-miR-200b-3p GAB1 0.0717138787925347 0.682858087587209 -0.831915995743376 3.76673378654882e-11 TargetScan -0.114097798587461 0.000333566384917416 NA NA NA hsa-miR-20a-5p GAB1 1.1531986665452 1.02385132917958e-11 -0.831915995743376 3.76673378654882e-11 MirTarget;miRNATAP -0.217496177428752 6.92624613942993e-12 NA NA NA hsa-miR-29b-1-5p GAB1 1.39669186711325 4.36960953138935e-11 -0.831915995743376 3.76673378654882e-11 mirMAP -0.142397390773295 2.67643381488282e-08 NA NA NA hsa-miR-29b-3p GAB1 -0.110721443686039 0.511264554091106 -0.831915995743376 3.76673378654882e-11 MirTarget -0.203126374824099 5.38114528889511e-10 NA NA NA hsa-miR-30b-5p GAB1 -0.400238605368173 0.00346540992719245 -0.831915995743376 3.76673378654882e-11 mirMAP -0.248226533484432 6.82202886359379e-10 NA NA NA hsa-miR-30c-5p GAB1 0.021222006155897 0.886366656528128 -0.831915995743376 3.76673378654882e-11 mirMAP -0.248089790487293 2.2434948597843e-11 NA NA NA hsa-miR-30d-3p GAB1 -0.577371911152798 2.02950840095287e-06 -0.831915995743376 3.76673378654882e-11 mirMAP -0.127490928886548 0.00542767502876259 NA NA NA hsa-miR-330-5p GAB1 0.944693925383906 5.04972895657346e-13 -0.831915995743376 3.76673378654882e-11 PITA;miRanda;miRNATAP -0.133007897402992 0.00147630717163987 NA NA NA hsa-miR-335-3p GAB1 0.336785882180547 0.0542446207938138 -0.831915995743376 3.76673378654882e-11 mirMAP -0.194675714267775 6.1586801205817e-10 NA NA NA hsa-miR-34a-5p GAB1 -0.117372471043915 0.364001947180738 -0.831915995743376 3.76673378654882e-11 MirTarget -0.319310495816852 5.19413385131325e-14 NA NA NA hsa-miR-374a-3p GAB1 -0.299190081500425 0.00682975596757891 -0.831915995743376 3.76673378654882e-11 mirMAP -0.233247950202743 3.71412272256375e-06 NA NA NA hsa-miR-429 GAB1 0.559451508722375 0.00563641638673083 -0.831915995743376 3.76673378654882e-11 miRanda;miRNATAP -0.157675410083423 6.97185522867417e-09 NA NA NA hsa-miR-450b-5p GAB1 1.25529820885833 1.18847120528666e-15 -0.831915995743376 3.76673378654882e-11 PITA;mirMAP;miRNATAP -0.109223092603731 0.00160672405199603 NA NA NA hsa-miR-590-3p GAB1 0.221436901462551 0.0965904764063157 -0.831915995743376 3.76673378654882e-11 miRanda;mirMAP -0.144815658756685 0.0005619946038746 NA NA NA hsa-miR-664a-3p GAB1 -0.256108763664991 0.0513188660751664 -0.831915995743376 3.76673378654882e-11 MirTarget -0.165046876418687 0.000102867451125228 NA NA NA hsa-miR-7-1-3p GAB1 1.13646121619622 1.49823237535933e-14 -0.831915995743376 3.76673378654882e-11 mirMAP -0.270306876627404 6.29708209047525e-14 NA NA NA hsa-miR-93-5p GAB1 1.61042951896619 5.1280369606967e-24 -0.831915995743376 3.76673378654882e-11 MirTarget;miRNATAP -0.287272613932399 7.54334018513474e-19 NA NA NA hsa-let-7d-5p GAB2 0.481757661442508 3.66030810124939e-07 -0.98900147424223 3.69131341348402e-12 MirTarget -0.376932235516626 1.16715794363593e-08 NA NA NA hsa-miR-125a-5p GAB2 0.215366061934933 0.119550904549401 -0.98900147424223 3.69131341348402e-12 mirMAP -0.207984380029935 5.24072869929354e-06 NA NA NA hsa-miR-1301-3p GAB2 2.13677668481885 6.11093268540831e-44 -0.98900147424223 3.69131341348402e-12 MirTarget -0.248345227308379 2.30280992393893e-11 NA NA NA hsa-miR-130b-5p GAB2 1.77265255049999 1.43627774829684e-29 -0.98900147424223 3.69131341348402e-12 mirMAP -0.267442011177388 8.03011825687901e-13 NA NA NA hsa-miR-141-3p GAB2 0.730011517758706 0.000120338355004032 -0.98900147424223 3.69131341348402e-12 mirMAP -0.230255339774892 1.44045654827615e-12 NA NA NA hsa-miR-181a-5p GAB2 0.819060835827404 1.38616688310277e-13 -0.98900147424223 3.69131341348402e-12 mirMAP -0.289902670686606 1.93198536618258e-07 NA NA NA hsa-miR-181b-5p GAB2 0.974255518824355 2.64876280203475e-16 -0.98900147424223 3.69131341348402e-12 mirMAP -0.333470918939516 6.60969194227176e-11 NA NA NA hsa-miR-18a-3p GAB2 1.82583720936229 7.51297960972179e-19 -0.98900147424223 3.69131341348402e-12 MirTarget -0.172651298346217 9.99967430844172e-09 NA NA NA hsa-miR-18a-5p GAB2 1.65455873230328 3.76457892277775e-20 -0.98900147424223 3.69131341348402e-12 miRNATAP -0.269655218595777 2.76994667339633e-16 NA NA NA hsa-miR-192-5p GAB2 0.380924502586635 0.00986961967409205 -0.98900147424223 3.69131341348402e-12 miRNAWalker2_validate -0.13269998908725 0.0019796783256104 NA NA NA hsa-miR-1976 GAB2 0.638808083289405 2.94840228896364e-07 -0.98900147424223 3.69131341348402e-12 MirTarget -0.175859270748072 0.000485287144009482 NA NA NA hsa-miR-200a-3p GAB2 0.607140814457753 0.00289840524858752 -0.98900147424223 3.69131341348402e-12 mirMAP -0.217529372864232 7.49108834933979e-13 NA NA NA hsa-miR-2355-3p GAB2 1.58434563546762 4.06578912176206e-18 -0.98900147424223 3.69131341348402e-12 miRNATAP -0.203036863526489 8.23212512728353e-10 NA NA NA hsa-miR-3127-5p GAB2 0.706677736144125 1.91821443636366e-05 -0.98900147424223 3.69131341348402e-12 mirMAP -0.101289901775494 0.00783639077466976 NA NA NA hsa-miR-3607-3p GAB2 1.01377165357363 9.13355519701165e-05 -0.98900147424223 3.69131341348402e-12 mirMAP -0.136992212199483 1.15168491165011e-08 NA NA NA hsa-miR-361-3p GAB2 0.272298288982435 0.0147874880476998 -0.98900147424223 3.69131341348402e-12 MirTarget;mirMAP -0.168842350548427 0.00304722168772833 NA NA NA hsa-miR-362-5p GAB2 0.41089772861323 0.0404254902071382 -0.98900147424223 3.69131341348402e-12 mirMAP -0.155400815662066 6.94375057487865e-07 NA NA NA hsa-miR-429 GAB2 0.559451508722375 0.00563641638673083 -0.98900147424223 3.69131341348402e-12 miRNATAP -0.198245694809961 1.16344313503561e-10 NA NA NA hsa-miR-452-3p GAB2 1.09618110917892 2.21867884261816e-07 -0.98900147424223 3.69131341348402e-12 mirMAP -0.131404336608382 7.87263434634948e-06 NA NA NA hsa-miR-589-3p GAB2 1.59559692667315 6.2886410639161e-15 -0.98900147424223 3.69131341348402e-12 mirMAP -0.20392182745811 3.83496721472661e-11 NA NA NA hsa-miR-590-3p GAB2 0.221436901462551 0.0965904764063157 -0.98900147424223 3.69131341348402e-12 PITA;miRanda -0.192633501184783 5.03829933419861e-05 NA NA NA hsa-miR-629-3p GAB2 1.43262037314105 2.37092217984413e-19 -0.98900147424223 3.69131341348402e-12 mirMAP -0.196723179222536 2.40122002170366e-07 NA NA NA hsa-miR-93-3p GAB2 1.69225547123293 1.50964095575087e-25 -0.98900147424223 3.69131341348402e-12 mirMAP -0.29727162844656 2.25077314571462e-16 NA NA NA hsa-miR-101-3p GNB1 -1.91263766544878 1.50270129259053e-39 0.466100662558098 1.66131410872152e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.149843226273743 5.04613289999851e-18 NA NA NA hsa-miR-29b-2-5p GNB1 -0.502720326849742 0.000730448246894952 0.466100662558098 1.66131410872152e-13 MirTarget -0.111723664189568 1.7652356299577e-09 NA NA NA hsa-miR-331-3p GNB2 0.906385914819361 4.27653809739414e-11 -0.0468779773646908 0.580461880163829 miRNAWalker2_validate;MirTarget;PITA;miRNATAP -0.118882323574846 5.62695706398967e-06 NA NA NA hsa-miR-103a-2-5p GNB4 1.37988337975616 6.74852943995612e-08 0.434625394424438 0.00248777724987897 MirTarget -0.105234672923841 6.32453058987173e-05 NA NA NA hsa-miR-27b-3p GNB4 -0.732682718863563 2.26896143573324e-09 0.434625394424438 0.00248777724987897 miRNAWalker2_validate -0.152820931997841 0.00254495405670561 NA NA NA hsa-miR-29b-3p GNB4 -0.110721443686039 0.511264554091106 0.434625394424438 0.00248777724987897 MirTarget -0.148515606956927 6.47781002960341e-05 NA NA NA hsa-miR-361-5p GNB4 0.0803683277369505 0.314043140368058 0.434625394424438 0.00248777724987897 miRanda;miRNATAP -0.222317805979136 0.00548893142743628 NA NA NA hsa-miR-429 GNB4 0.559451508722375 0.00563641638673083 0.434625394424438 0.00248777724987897 miRanda -0.223803606524415 1.50861510159643e-13 NA NA NA hsa-miR-501-5p GNB4 1.02806906860218 1.63456814370548e-09 0.434625394424438 0.00248777724987897 mirMAP -0.142222550410317 0.000103910520130719 NA NA NA hsa-miR-93-5p GNB4 1.61042951896619 5.1280369606967e-24 0.434625394424438 0.00248777724987897 miRNAWalker2_validate -0.129799245257303 0.000553281290256018 NA NA NA hsa-miR-96-5p GNB4 1.42326703011157 4.39736150032373e-14 0.434625394424438 0.00248777724987897 MirTarget -0.222144687343025 2.98066618172876e-12 NA NA NA hsa-miR-128-3p GNB5 -0.170677254601174 0.20412808476528 0.917717395197355 1.50483049166727e-23 miRNAWalker2_validate -0.118666358355235 0.000135984838965614 NA NA NA hsa-miR-148a-3p GNB5 -0.428944290834563 0.00954246923521465 0.917717395197355 1.50483049166727e-23 miRNAWalker2_validate -0.116270378338527 3.46989962142575e-06 NA NA NA hsa-miR-217 GNB5 -1.35391381055929 2.42394951427902e-09 0.917717395197355 1.50483049166727e-23 miRanda -0.117399191669208 4.21140262907369e-11 NA NA NA hsa-miR-26b-5p GNB5 -0.254478038884324 0.0285227763044636 0.917717395197355 1.50483049166727e-23 miRNAWalker2_validate -0.173781332534163 1.25446729769197e-06 NA NA NA hsa-miR-338-3p GNB5 -0.948755228846395 8.99167125682392e-08 0.917717395197355 1.50483049166727e-23 miRanda -0.106355732896138 4.18448677150113e-06 NA NA NA hsa-miR-320b GNG11 1.23473838180754 3.04337566045537e-14 -0.457273781294273 0.00183160907075037 miRanda -0.224274401224359 3.59907165774881e-09 NA NA NA hsa-miR-140-5p GNG12 -0.412389003031485 0.000136051708543369 -0.229202139720909 0.0250475379704555 PITA;miRanda -0.134715839462402 0.0010850909223448 NA NA NA hsa-miR-28-5p GNG12 -0.026996999089909 0.733047113251652 -0.229202139720909 0.0250475379704555 PITA;miRanda -0.240049752558578 2.59100377532133e-05 NA NA NA hsa-miR-30d-3p GNG12 -0.577371911152798 2.02950840095287e-06 -0.229202139720909 0.0250475379704555 mirMAP -0.218992490146666 1.26213229239791e-09 NA NA NA hsa-miR-374a-5p GNG12 -0.621903385111545 6.61791773205282e-12 -0.229202139720909 0.0250475379704555 mirMAP -0.142652973262067 0.00340230327070474 NA NA NA hsa-miR-374b-5p GNG12 -0.288413933608091 0.0041474558664058 -0.229202139720909 0.0250475379704555 mirMAP -0.335371886812206 1.24401033850306e-14 NA NA NA hsa-miR-409-5p GNG12 0.491285368786351 0.0165413843067426 -0.229202139720909 0.0250475379704555 PITA -0.112255441775039 1.86101629997431e-07 NA NA NA hsa-miR-423-5p GNG12 0.60141781325829 1.62940950644999e-07 -0.229202139720909 0.0250475379704555 miRNAWalker2_validate -0.15452866245864 5.76708984314237e-05 NA NA NA hsa-miR-590-3p GNG12 0.221436901462551 0.0965904764063157 -0.229202139720909 0.0250475379704555 miRanda;mirMAP -0.109436768392884 0.00108913938845348 NA NA NA hsa-miR-590-5p GNG12 0.763025362395968 3.65305892505623e-09 -0.229202139720909 0.0250475379704555 PITA -0.162980782845926 1.42844920041051e-06 NA NA NA hsa-miR-96-5p GNG12 1.42326703011157 4.39736150032373e-14 -0.229202139720909 0.0250475379704555 TargetScan -0.119950329982978 1.45488060901013e-07 NA NA NA hsa-miR-30d-3p GNG2 -0.577371911152798 2.02950840095287e-06 0.153164603004257 0.379559786922516 mirMAP -0.16417366531823 0.00843494522705093 NA NA NA hsa-miR-324-5p GNG2 1.66709479707179 1.45961450445769e-23 0.153164603004257 0.379559786922516 miRanda -0.211723589048679 9.62118376757002e-07 NA NA NA hsa-miR-335-3p GNG2 0.336785882180547 0.0542446207938138 0.153164603004257 0.379559786922516 mirMAP -0.168959087446873 9.28594859552728e-05 NA NA NA hsa-miR-429 GNG2 0.559451508722375 0.00563641638673083 0.153164603004257 0.379559786922516 miRanda;miRNATAP -0.327211887971511 1.44221421172785e-19 NA NA NA hsa-miR-500a-5p GNG2 0.675401699376111 8.24389004707854e-05 0.153164603004257 0.379559786922516 mirMAP -0.136091490166989 0.00196751897553701 NA NA NA hsa-miR-590-5p GNG2 0.763025362395968 3.65305892505623e-09 0.153164603004257 0.379559786922516 miRanda;miRNATAP -0.312765363069043 5.12230023330908e-08 NA NA NA hsa-miR-944 GNG2 1.47323925060177 2.61626403984929e-13 0.153164603004257 0.379559786922516 mirMAP -0.232457598856729 1.32271495551851e-10 NA NA NA hsa-miR-142-5p GNG4 0.288897753038094 0.0900009317815725 -0.598998895927056 0.0295751028233577 mirMAP -0.270535796041951 0.000119973919699869 NA NA NA hsa-miR-342-3p GNG4 0.99756868977753 9.28499866272332e-10 -0.598998895927056 0.0295751028233577 mirMAP -0.195731240735478 0.00704735321746139 NA NA NA hsa-let-7a-5p GNG5 -0.439381775414001 3.1119785480023e-05 -0.0139855857337396 0.855320565842147 MirTarget;TargetScan;miRNATAP -0.169708149988811 5.48111263103411e-08 NA NA NA hsa-let-7b-5p GNG5 -0.2489842756826 0.0211384499461719 -0.0139855857337396 0.855320565842147 MirTarget;miRNATAP -0.135616252393189 1.07488334800303e-05 NA NA NA hsa-let-7e-5p GNG5 0.0857356192778891 0.512869729833211 -0.0139855857337396 0.855320565842147 miRNAWalker2_validate;MirTarget;miRNATAP -0.100445000782102 7.72458109567202e-05 NA NA NA hsa-miR-1271-5p GNG7 0.564681884899804 0.000425257395055278 -1.96928829336781 3.56688408795345e-19 mirMAP -0.192381861511945 0.00188423508760484 NA NA NA hsa-miR-141-3p GNG7 0.730011517758706 0.000120338355004032 -1.96928829336781 3.56688408795345e-19 MirTarget;TargetScan;miRNATAP -0.279002053512395 6.33254756334346e-08 NA NA NA hsa-miR-17-3p GNG7 -0.0127974722290336 0.909559935689875 -1.96928829336781 3.56688408795345e-19 mirMAP -0.306981069928375 0.000549461084972192 NA NA NA hsa-miR-181a-2-3p GNG7 0.562132917934234 4.79313448225408e-05 -1.96928829336781 3.56688408795345e-19 mirMAP -0.201681248291272 0.0049142002731587 NA NA NA hsa-miR-182-5p GNG7 1.15060905311096 6.25565852529946e-10 -1.96928829336781 3.56688408795345e-19 mirMAP -0.210592536921466 5.80269928123739e-05 NA NA NA hsa-miR-185-3p GNG7 0.653637407906201 6.54212996668668e-05 -1.96928829336781 3.56688408795345e-19 mirMAP -0.205880658285681 0.000654940753508538 NA NA NA hsa-miR-18a-3p GNG7 1.82583720936229 7.51297960972179e-19 -1.96928829336781 3.56688408795345e-19 mirMAP -0.393344501121379 2.50894162089134e-17 NA NA NA hsa-miR-18a-5p GNG7 1.65455873230328 3.76457892277775e-20 -1.96928829336781 3.56688408795345e-19 mirMAP -0.473993477190813 2.50553479714032e-20 NA NA NA hsa-miR-193b-5p GNG7 1.10486595354104 6.41489920661805e-11 -1.96928829336781 3.56688408795345e-19 mirMAP -0.442850003718459 3.76350255190172e-15 NA NA NA hsa-miR-200a-3p GNG7 0.607140814457753 0.00289840524858752 -1.96928829336781 3.56688408795345e-19 MirTarget;miRNATAP -0.130969832945733 0.00710530058072902 NA NA NA hsa-miR-22-5p GNG7 0.706731861922839 3.44318705980007e-07 -1.96928829336781 3.56688408795345e-19 mirMAP -0.377843403610421 8.29139480235812e-08 NA NA NA hsa-miR-224-5p GNG7 1.94534596857416 1.88348779207332e-19 -1.96928829336781 3.56688408795345e-19 mirMAP -0.415294565777656 2.01955887857522e-22 NA NA NA hsa-miR-23a-3p GNG7 0.348231698801568 6.4911858506572e-05 -1.96928829336781 3.56688408795345e-19 mirMAP -0.603865353508548 1.12455740362181e-07 NA NA NA hsa-miR-31-3p GNG7 2.10124531535908 1.70135756565194e-08 -1.96928829336781 3.56688408795345e-19 mirMAP -0.260502892268356 2.95714676798468e-25 NA NA NA hsa-miR-31-5p GNG7 2.79079137807505 1.72181058015659e-13 -1.96928829336781 3.56688408795345e-19 mirMAP -0.27004057657821 3.8876877168793e-28 NA NA NA hsa-miR-330-5p GNG7 0.944693925383906 5.04972895657346e-13 -1.96928829336781 3.56688408795345e-19 mirMAP -0.201234300748704 0.00700393165048644 NA NA NA hsa-miR-3614-5p GNG7 0.955957969488529 2.95347675446694e-05 -1.96928829336781 3.56688408795345e-19 mirMAP -0.131175927688257 0.00235872683316611 NA NA NA hsa-miR-3615 GNG7 0.761416334979744 9.83072409815373e-09 -1.96928829336781 3.56688408795345e-19 mirMAP -0.258176057685396 0.000482601354399127 NA NA NA hsa-miR-671-5p GNG7 1.90920358947989 6.8158317757852e-31 -1.96928829336781 3.56688408795345e-19 mirMAP -0.419016918070274 3.92972470656425e-14 NA NA NA hsa-miR-92a-3p GNG7 0.994679542307232 1.32587679156217e-16 -1.96928829336781 3.56688408795345e-19 miRNAWalker2_validate -0.587398977704882 9.08481842165774e-14 NA NA NA hsa-miR-939-5p GNG7 1.00479167005165 2.93105661166695e-09 -1.96928829336781 3.56688408795345e-19 mirMAP -0.291763330715998 1.45707229488921e-06 NA NA NA hsa-miR-940 GNG7 1.25303020594374 1.3005368359451e-10 -1.96928829336781 3.56688408795345e-19 MirTarget -0.226445914826704 7.12097382175534e-06 NA NA NA hsa-miR-96-5p GNG7 1.42326703011157 4.39736150032373e-14 -1.96928829336781 3.56688408795345e-19 mirMAP -0.3277424570507 9.4044996581757e-11 NA NA NA hsa-miR-219a-1-3p GNGT2 0.54812960890496 0.000643480374673536 0.32070763940756 0.0862832347649647 MirTarget -0.21755454573517 1.57683627840316e-05 NA NA NA hsa-miR-342-5p GRIN1 0.862385578881784 1.60007936373305e-08 -0.216513590979218 0.478880866360134 PITA;mirMAP;miRNATAP -0.229316179564601 0.00785528942464768 NA NA NA hsa-miR-361-3p GRIN1 0.272298288982435 0.0147874880476998 -0.216513590979218 0.478880866360134 mirMAP -0.34495934953084 0.00399395538442608 NA NA NA hsa-miR-3614-5p GRIN1 0.955957969488529 2.95347675446694e-05 -0.216513590979218 0.478880866360134 mirMAP -0.25604505085085 8.34337050545239e-06 NA NA NA hsa-let-7a-3p GRIN2A 0.0966652362351867 0.423761916840503 -1.01732360566583 0.0139626358806765 mirMAP -0.557269957468621 0.000205338707531814 NA NA NA hsa-miR-148b-5p GRIN2A 1.1533193737265 7.26420964688337e-13 -1.01732360566583 0.0139626358806765 mirMAP -0.32986433185178 0.00306063952336288 NA NA NA hsa-miR-182-5p GRIN2A 1.15060905311096 6.25565852529946e-10 -1.01732360566583 0.0139626358806765 mirMAP -0.339511628609868 0.000368767615559797 NA NA NA hsa-miR-224-5p GRIN2A 1.94534596857416 1.88348779207332e-19 -1.01732360566583 0.0139626358806765 mirMAP -0.448630777019161 1.89242409660912e-08 NA NA NA hsa-miR-338-3p GRIN2A -0.948755228846395 8.99167125682392e-08 -1.01732360566583 0.0139626358806765 miRanda -0.354271798811003 0.000420629394820172 NA NA NA hsa-miR-590-5p GRIN2A 0.763025362395968 3.65305892505623e-09 -1.01732360566583 0.0139626358806765 miRanda -0.397259280589495 0.00404151205213869 NA NA NA hsa-miR-7-1-3p GRIN2A 1.13646121619622 1.49823237535933e-14 -1.01732360566583 0.0139626358806765 mirMAP -0.412725159617987 0.000529534853015074 NA NA NA hsa-miR-877-5p GRIN2A 1.97571572671705 2.0032239372269e-19 -1.01732360566583 0.0139626358806765 mirMAP -0.338278706484257 7.54331897535218e-05 NA NA NA hsa-miR-92a-3p GRIN2A 0.994679542307232 1.32587679156217e-16 -1.01732360566583 0.0139626358806765 mirMAP -0.675226859224122 3.48322494857714e-06 NA NA NA hsa-let-7a-3p HGF 0.0966652362351867 0.423761916840503 -0.628808099278418 0.0248850412356301 mirMAP -0.678925182790585 1.16230629525026e-11 NA NA NA hsa-miR-141-3p HGF 0.730011517758706 0.000120338355004032 -0.628808099278418 0.0248850412356301 MirTarget;TargetScan -0.561125900874801 1.20618910138091e-19 NA NA NA hsa-miR-200a-3p HGF 0.607140814457753 0.00289840524858752 -0.628808099278418 0.0248850412356301 MirTarget -0.46418885165035 1.63121170062695e-15 NA NA NA hsa-miR-203a-3p HGF 0.0441399794719697 0.880456392176704 -0.628808099278418 0.0248850412356301 MirTarget -0.321186869823737 2.52059425443943e-15 NA NA NA hsa-miR-224-3p HGF 0.502645536188015 0.0081142387260641 -0.628808099278418 0.0248850412356301 mirMAP -0.382701156821044 2.14724084930058e-09 NA NA NA hsa-miR-26b-5p HGF -0.254478038884324 0.0285227763044636 -0.628808099278418 0.0248850412356301 MirTarget;miRNATAP -0.293463586038775 0.00556150652071372 NA NA NA hsa-miR-29a-5p HGF 0.323252792625584 0.0370417231222825 -0.628808099278418 0.0248850412356301 mirMAP -0.33517175543393 2.02072168292234e-05 NA NA NA hsa-miR-30b-5p HGF -0.400238605368173 0.00346540992719245 -0.628808099278418 0.0248850412356301 mirMAP -0.339568782547391 0.000139133814424322 NA NA NA hsa-miR-30c-5p HGF 0.021222006155897 0.886366656528128 -0.628808099278418 0.0248850412356301 mirMAP -0.364505623339003 9.30153464059718e-06 NA NA NA hsa-miR-33a-3p HGF 0.20371038027126 0.212335697664505 -0.628808099278418 0.0248850412356301 mirMAP -0.245106862650746 0.0012734452978666 NA NA NA hsa-miR-429 HGF 0.559451508722375 0.00563641638673083 -0.628808099278418 0.0248850412356301 miRanda -0.406558130985217 6.89356985764421e-12 NA NA NA hsa-miR-590-5p HGF 0.763025362395968 3.65305892505623e-09 -0.628808099278418 0.0248850412356301 miRanda -0.578847824892088 3.36079943237795e-10 NA NA NA hsa-miR-651-5p HGF 0.504713329111777 0.00155970216047171 -0.628808099278418 0.0248850412356301 MirTarget -0.32162676958462 2.46985420767702e-05 NA NA NA hsa-miR-7-1-3p HGF 1.13646121619622 1.49823237535933e-14 -0.628808099278418 0.0248850412356301 mirMAP -0.279818488965689 0.000518564555493889 NA NA NA hsa-miR-944 HGF 1.47323925060177 2.61626403984929e-13 -0.628808099278418 0.0248850412356301 mirMAP -0.331250406167246 1.57938016792516e-08 NA NA NA hsa-let-7a-5p HRAS -0.439381775414001 3.1119785480023e-05 0.26280245681614 0.0556242904507885 miRNAWalker2_validate;miRTarBase -0.301645525492195 8.02100955354543e-08 20607356;23134218;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression glioblastoma;lung squamous cell cancer;lung cancer;lung cancer;pancreatic cancer hsa-let-7b-5p HRAS -0.2489842756826 0.0211384499461719 0.26280245681614 0.0556242904507885 miRTarBase -0.216577181164546 9.6758212516064e-05 20607356;20881268;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;drug resistance;;;progression glioblastoma;colorectal cancer;lung cancer;lung cancer;pancreatic cancer hsa-miR-143-3p HRAS -1.33760181792708 4.15335119989612e-12 0.26280245681614 0.0556242904507885 miRNAWalker2_validate;miRTarBase -0.249594509349032 2.27678793354297e-17 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-181d-5p HRAS 0.367649966373544 0.00537300571455306 0.26280245681614 0.0556242904507885 miRNAWalker2_validate;miRTarBase -0.122856153096347 0.00677992276763114 NA NA NA hsa-miR-218-5p HTR7 -1.0725338636959 3.61493686604269e-09 2.02429231196869 8.90659081765471e-10 miRNATAP -0.536667114246185 5.6393161173998e-12 NA NA NA hsa-miR-29a-3p HTR7 -1.26881270980079 2.82496991513463e-22 2.02429231196869 8.90659081765471e-10 miRNATAP -0.412367401454892 0.000122704801518448 NA NA NA hsa-miR-29b-3p HTR7 -0.110721443686039 0.511264554091106 2.02429231196869 8.90659081765471e-10 miRNATAP -0.322957458478733 0.000199349273967595 NA NA NA hsa-miR-29c-3p HTR7 -2.08166260448948 8.3238369390898e-24 2.02429231196869 8.90659081765471e-10 miRNATAP -0.536310112523941 3.23691388291981e-16 NA NA NA hsa-miR-335-5p HTR7 -1.17227779671552 1.49282618530733e-10 2.02429231196869 8.90659081765471e-10 miRNAWalker2_validate -0.615996892736259 8.29341828462363e-16 NA NA NA hsa-miR-375 HTR7 -4.24070205340868 7.48368361454041e-28 2.02429231196869 8.90659081765471e-10 miRanda -0.24208719755338 4.69268122400502e-12 NA NA NA hsa-miR-491-5p HTR7 -0.541680329196715 0.00135829217561865 2.02429231196869 8.90659081765471e-10 miRanda -0.302376242840552 0.000813306227740765 NA NA NA hsa-let-7a-3p IGF1 0.0966652362351867 0.423761916840503 -1.83606554417213 4.89445874007951e-10 mirMAP -0.628414381189287 5.27761426031282e-09 NA NA NA hsa-miR-103a-2-5p IGF1 1.37988337975616 6.74852943995612e-08 -1.83606554417213 4.89445874007951e-10 mirMAP -0.45438875584609 1.7540230331713e-17 NA NA NA hsa-miR-130a-3p IGF1 0.67051191119964 4.89747518735144e-06 -1.83606554417213 4.89445874007951e-10 MirTarget -0.700417159997035 4.55001564446877e-16 NA NA NA hsa-miR-130b-3p IGF1 1.44628430084411 9.13980959861273e-24 -1.83606554417213 4.89445874007951e-10 MirTarget -0.381225145442848 1.06880616791146e-05 NA NA NA hsa-miR-15b-3p IGF1 1.05020782493504 6.38723677324836e-14 -1.83606554417213 4.89445874007951e-10 mirMAP -0.600110692355124 2.35788363622271e-11 NA NA NA hsa-miR-16-1-3p IGF1 0.955017760172879 5.95379292601146e-11 -1.83606554417213 4.89445874007951e-10 mirMAP -0.654262965462375 3.52738431783344e-14 NA NA NA hsa-miR-186-5p IGF1 0.353452958261612 0.000145058448579496 -1.83606554417213 4.89445874007951e-10 mirMAP -0.366692143669484 0.00959838552779203 NA NA NA hsa-miR-19a-3p IGF1 1.35800152353624 2.80940447111944e-12 -1.83606554417213 4.89445874007951e-10 MirTarget -0.675360942734142 3.91550460498543e-27 NA NA NA hsa-miR-19b-1-5p IGF1 0.757034032029085 2.99828133413343e-07 -1.83606554417213 4.89445874007951e-10 mirMAP -0.699245326551041 2.59396405008731e-16 NA NA NA hsa-miR-19b-3p IGF1 0.538732279378089 0.000622008277870679 -1.83606554417213 4.89445874007951e-10 MirTarget -0.750279055807441 5.4834038782256e-21 NA NA NA hsa-miR-205-3p IGF1 1.2960640797621 5.80786479909147e-11 -1.83606554417213 4.89445874007951e-10 mirMAP -0.600295652502196 5.84026535331867e-22 NA NA NA hsa-miR-20a-3p IGF1 1.34885093664027 2.07697464119202e-12 -1.83606554417213 4.89445874007951e-10 mirMAP -0.573755673684406 5.83753051386334e-19 NA NA NA hsa-miR-224-3p IGF1 0.502645536188015 0.0081142387260641 -1.83606554417213 4.89445874007951e-10 mirMAP -0.397083320323672 6.59448390538765e-09 NA NA NA hsa-miR-27a-3p IGF1 0.348456440505425 0.00126682892514312 -1.83606554417213 4.89445874007951e-10 miRNAWalker2_validate;miRTarBase -0.630796790452773 1.61575924809895e-07 NA NA NA hsa-miR-301a-3p IGF1 2.14132004241926 4.46255413526808e-25 -1.83606554417213 4.89445874007951e-10 MirTarget -0.542962161756586 7.28279283702467e-21 NA NA NA hsa-miR-320a IGF1 0.801356001806321 4.91397101474502e-09 -1.83606554417213 4.89445874007951e-10 miRNATAP -0.471166482627833 4.87790750232857e-07 NA NA NA hsa-miR-320b IGF1 1.23473838180754 3.04337566045537e-14 -1.83606554417213 4.89445874007951e-10 miRNATAP -0.435970586012069 1.99260325159595e-08 NA NA NA hsa-miR-33a-3p IGF1 0.20371038027126 0.212335697664505 -1.83606554417213 4.89445874007951e-10 MirTarget -0.301086727433913 0.000210494168325812 NA NA NA hsa-miR-3607-3p IGF1 1.01377165357363 9.13355519701165e-05 -1.83606554417213 4.89445874007951e-10 mirMAP -0.279152595145872 1.84181237021726e-08 NA NA NA hsa-miR-362-5p IGF1 0.41089772861323 0.0404254902071382 -1.83606554417213 4.89445874007951e-10 mirMAP -0.266319117984938 4.10437106471054e-05 NA NA NA hsa-miR-450b-5p IGF1 1.25529820885833 1.18847120528666e-15 -1.83606554417213 4.89445874007951e-10 MirTarget;PITA;mirMAP;miRNATAP -0.248366118573042 0.00221127559765416 NA NA NA hsa-miR-452-5p IGF1 0.373288744398455 0.0348485937209964 -1.83606554417213 4.89445874007951e-10 MirTarget;mirMAP -0.266246297258034 0.000308015705405959 NA NA NA hsa-miR-454-3p IGF1 1.54137391927201 4.15861570449376e-20 -1.83606554417213 4.89445874007951e-10 MirTarget -0.626033221014056 8.04576753877952e-18 NA NA NA hsa-miR-576-5p IGF1 0.940432050128373 6.90227595663302e-12 -1.83606554417213 4.89445874007951e-10 PITA;mirMAP;miRNATAP -0.73695380930135 6.7749669820951e-16 NA NA NA hsa-miR-590-3p IGF1 0.221436901462551 0.0965904764063157 -1.83606554417213 4.89445874007951e-10 MirTarget;miRanda;mirMAP;miRNATAP -0.293536383987437 0.00288981376091861 NA NA NA hsa-miR-629-5p IGF1 0.461215538037447 8.95262667860215e-06 -1.83606554417213 4.89445874007951e-10 mirMAP -0.473288980212107 0.00016595454212857 NA NA NA hsa-miR-940 IGF1 1.25303020594374 1.3005368359451e-10 -1.83606554417213 4.89445874007951e-10 MirTarget;PITA;miRNATAP -0.179832112337034 0.00706374566547861 NA NA NA hsa-let-7g-5p IGF1R -0.250780249469264 0.00939610188330072 0.658946603715235 3.61776569897156e-07 MirTarget;miRNATAP -0.155732549646198 0.00895625538301226 NA NA NA hsa-miR-125a-5p IGF1R 0.215366061934933 0.119550904549401 0.658946603715235 3.61776569897156e-07 mirMAP -0.122652006063788 0.00300283808252089 NA NA NA hsa-miR-125b-5p IGF1R -0.993460109818276 5.07736727659894e-12 0.658946603715235 3.61776569897156e-07 mirMAP -0.115202680031871 0.00303906338889069 NA NA NA hsa-miR-139-5p IGF1R -1.46099200329485 7.85040381494472e-22 0.658946603715235 3.61776569897156e-07 miRNAWalker2_validate;miRTarBase;MirTarget;PITA -0.147245183735145 3.99004378002884e-05 26097570 Furthermore we identified insulin-like growth factor 1 receptor IGF1R as a target of miR-139-5p and miR-139-5p function as a tumor suppressor via targeting IGF1R in NSCLC; Our results indicated that miR-139-5p acts as a tumor suppressor in NSCLC partially via down-regulating IGF1R expression lung squamous cell cancer hsa-miR-140-3p IGF1R -0.967453553824782 7.6999446305445e-23 0.658946603715235 3.61776569897156e-07 mirMAP -0.196835213061393 0.000425535569554514 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-140-5p IGF1R -0.412389003031485 0.000136051708543369 0.658946603715235 3.61776569897156e-07 PITA;miRNATAP -0.223557474307117 2.1291855472217e-05 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-146b-5p IGF1R 0.917975986853978 3.33749259316025e-09 0.658946603715235 3.61776569897156e-07 miRanda -0.122104654410604 0.00073816915030413 NA NA NA hsa-miR-150-5p IGF1R -0.243749814009231 0.331546276920338 0.658946603715235 3.61776569897156e-07 mirMAP -0.142756661920241 1.67670626260167e-10 NA NA NA hsa-miR-155-5p IGF1R 0.533437622040649 0.00248671179205372 0.658946603715235 3.61776569897156e-07 mirMAP -0.224562941255931 1.20598024492178e-12 NA NA NA hsa-miR-15a-5p IGF1R 0.783550182002274 2.60699595655907e-11 0.658946603715235 3.61776569897156e-07 miRNATAP -0.237899859491516 5.31568322470779e-07 NA NA NA hsa-miR-16-1-3p IGF1R 0.955017760172879 5.95379292601146e-11 0.658946603715235 3.61776569897156e-07 mirMAP -0.116704120509115 0.00242672527225861 NA NA NA hsa-miR-186-5p IGF1R 0.353452958261612 0.000145058448579496 0.658946603715235 3.61776569897156e-07 mirMAP -0.20597527734222 0.000818139228888561 NA NA NA hsa-miR-19a-3p IGF1R 1.35800152353624 2.80940447111944e-12 0.658946603715235 3.61776569897156e-07 mirMAP -0.112424087845666 8.44172640684963e-05 NA NA NA hsa-miR-29a-5p IGF1R 0.323252792625584 0.0370417231222825 0.658946603715235 3.61776569897156e-07 miRNATAP -0.137318447004994 0.000183839216350161 NA NA NA hsa-miR-29b-2-5p IGF1R -0.502720326849742 0.000730448246894952 0.658946603715235 3.61776569897156e-07 mirMAP -0.264948480596983 1.56682091635764e-12 NA NA NA hsa-miR-29b-3p IGF1R -0.110721443686039 0.511264554091106 0.658946603715235 3.61776569897156e-07 mirMAP -0.254632632247586 1.39236690585097e-14 NA NA NA hsa-miR-29c-3p IGF1R -2.08166260448948 8.3238369390898e-24 0.658946603715235 3.61776569897156e-07 mirMAP -0.111585311418395 2.00656321961855e-05 NA NA NA hsa-miR-30a-5p IGF1R -1.79779915425811 1.93360169837799e-26 0.658946603715235 3.61776569897156e-07 miRNAWalker2_validate;mirMAP;miRNATAP -0.183683218204462 6.72293627860893e-09 26025408 MiR 30a suppresses non small cell lung cancer progression through AKT signaling pathway by targeting IGF1R progression lung squamous cell cancer hsa-miR-30b-5p IGF1R -0.400238605368173 0.00346540992719245 0.658946603715235 3.61776569897156e-07 mirMAP -0.25107831096127 9.89527887529752e-10 NA NA NA hsa-miR-30c-5p IGF1R 0.021222006155897 0.886366656528128 0.658946603715235 3.61776569897156e-07 mirMAP;miRNATAP -0.244015878253709 1.23951540420282e-10 NA NA NA hsa-miR-30d-5p IGF1R -0.38399848121878 0.000171129616944749 0.658946603715235 3.61776569897156e-07 mirMAP;miRNATAP -0.201059970637282 0.000318689995409976 NA NA NA hsa-miR-30e-5p IGF1R -1.02114836019762 6.81961221797866e-17 0.658946603715235 3.61776569897156e-07 mirMAP -0.286483274229708 1.43613898306972e-10 NA NA NA hsa-miR-320a IGF1R 0.801356001806321 4.91397101474502e-09 0.658946603715235 3.61776569897156e-07 miRNAWalker2_validate;PITA;mirMAP;miRNATAP -0.12353574596143 0.0026605822492909 NA NA NA hsa-miR-342-3p IGF1R 0.99756868977753 9.28499866272332e-10 0.658946603715235 3.61776569897156e-07 mirMAP -0.23145563539146 7.79737236924884e-12 NA NA NA hsa-miR-342-5p IGF1R 0.862385578881784 1.60007936373305e-08 0.658946603715235 3.61776569897156e-07 mirMAP -0.202277416833612 3.0388946126467e-08 NA NA NA hsa-miR-34a-5p IGF1R -0.117372471043915 0.364001947180738 0.658946603715235 3.61776569897156e-07 miRNAWalker2_validate -0.311787067279754 6.87826334266983e-13 NA NA NA hsa-miR-362-3p IGF1R -0.697212068252854 2.61718493418184e-06 0.658946603715235 3.61776569897156e-07 PITA -0.168307563103232 1.00229822371416e-05 NA NA NA hsa-miR-374a-5p IGF1R -0.621903385111545 6.61791773205282e-12 0.658946603715235 3.61776569897156e-07 mirMAP -0.16988335502384 0.0064642031028813 NA NA NA hsa-miR-374b-5p IGF1R -0.288413933608091 0.0041474558664058 0.658946603715235 3.61776569897156e-07 mirMAP -0.222283776754656 9.22433274038686e-05 NA NA NA hsa-miR-497-5p IGF1R -0.966244470847844 5.26505649147857e-12 0.658946603715235 3.61776569897156e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.132785924595479 0.000876505984752571 NA NA NA hsa-miR-500a-3p IGF1R 0.457959128173392 0.000691656736597067 0.658946603715235 3.61776569897156e-07 mirMAP -0.289000053170829 2.94945339306885e-12 NA NA NA hsa-miR-532-5p IGF1R -0.021857649390892 0.830992272120134 0.658946603715235 3.61776569897156e-07 miRNATAP -0.200326248020098 0.000356759068484248 NA NA NA hsa-miR-130a-3p IGF2 0.67051191119964 4.89747518735144e-06 0.130732308478005 0.606612547963814 mirMAP -0.324538284523359 1.3160813634391e-05 NA NA NA hsa-miR-141-3p IGF2 0.730011517758706 0.000120338355004032 0.130732308478005 0.606612547963814 MirTarget;TargetScan -0.430572541444147 2.6570976244206e-14 NA NA NA hsa-miR-148a-3p IGF2 -0.428944290834563 0.00954246923521465 0.130732308478005 0.606612547963814 mirMAP -0.247562333397005 0.00020022997586927 NA NA NA hsa-miR-148b-3p IGF2 0.386859166050437 4.6728211830726e-06 0.130732308478005 0.606612547963814 mirMAP -0.815373978565952 3.20305506500657e-10 NA NA NA hsa-miR-150-5p IGF2 -0.243749814009231 0.331546276920338 0.130732308478005 0.606612547963814 miRNAWalker2_validate -0.13360557433827 0.00238685938902513 NA NA NA hsa-miR-192-5p IGF2 0.380924502586635 0.00986961967409205 0.130732308478005 0.606612547963814 mirMAP -0.474719611528428 1.21693916595116e-10 NA NA NA hsa-miR-193a-3p IGF2 0.22120710726779 0.111827069464729 0.130732308478005 0.606612547963814 mirMAP -0.235190560615962 0.00316740702451148 NA NA NA hsa-miR-19a-3p IGF2 1.35800152353624 2.80940447111944e-12 0.130732308478005 0.606612547963814 mirMAP -0.307472958113455 2.3133912535587e-08 NA NA NA hsa-miR-19b-3p IGF2 0.538732279378089 0.000622008277870679 0.130732308478005 0.606612547963814 mirMAP -0.429363302728369 4.95114367701055e-10 NA NA NA hsa-miR-200a-3p IGF2 0.607140814457753 0.00289840524858752 0.130732308478005 0.606612547963814 MirTarget -0.376609229788577 1.16212138455988e-12 NA NA NA hsa-miR-210-3p IGF2 3.16015094635767 4.37095019705785e-31 0.130732308478005 0.606612547963814 MirTarget -0.218127501529348 6.72778440957983e-09 NA NA NA hsa-miR-224-3p IGF2 0.502645536188015 0.0081142387260641 0.130732308478005 0.606612547963814 mirMAP -0.18239543191048 0.00181791082798036 NA NA NA hsa-miR-23a-5p IGF2 1.662156284689 7.34844237202118e-15 0.130732308478005 0.606612547963814 MirTarget -0.24283012664811 1.65622668182056e-06 NA NA NA hsa-miR-23b-5p IGF2 0.141208007066527 0.420202986869364 0.130732308478005 0.606612547963814 MirTarget -0.337179225699117 1.78808920024544e-07 NA NA NA hsa-miR-301a-3p IGF2 2.14132004241926 4.46255413526808e-25 0.130732308478005 0.606612547963814 mirMAP -0.190498569164423 0.000170950020883423 NA NA NA hsa-miR-31-5p IGF2 2.79079137807505 1.72181058015659e-13 0.130732308478005 0.606612547963814 mirMAP -0.125119744160946 1.23317042063549e-05 NA NA NA hsa-miR-339-5p IGF2 1.07771430326938 2.45772601859307e-09 0.130732308478005 0.606612547963814 mirMAP -0.332729784750595 2.36920833741934e-08 NA NA NA hsa-miR-342-5p IGF2 0.862385578881784 1.60007936373305e-08 0.130732308478005 0.606612547963814 MirTarget;mirMAP;miRNATAP -0.315934392774269 9.06374793058564e-06 NA NA NA hsa-miR-34a-5p IGF2 -0.117372471043915 0.364001947180738 0.130732308478005 0.606612547963814 mirMAP -0.347400380241615 4.93699500037352e-05 NA NA NA hsa-miR-361-3p IGF2 0.272298288982435 0.0147874880476998 0.130732308478005 0.606612547963814 mirMAP -0.460050658130368 3.2519479752365e-06 NA NA NA hsa-miR-454-3p IGF2 1.54137391927201 4.15861570449376e-20 0.130732308478005 0.606612547963814 mirMAP -0.341063238529512 5.62028286180104e-08 NA NA NA hsa-miR-93-5p IGF2 1.61042951896619 5.1280369606967e-24 0.130732308478005 0.606612547963814 miRNAWalker2_validate -0.26769917639849 5.05900818706672e-05 NA NA NA hsa-miR-125a-3p IKBKB 0.116035800853173 0.444825559956959 -0.396740795566287 2.1815201064403e-05 miRanda -0.108503103251697 5.57509033653017e-05 NA NA NA hsa-miR-151a-3p IKBKB 0.131002217498676 0.295273522160941 -0.396740795566287 2.1815201064403e-05 miRNAWalker2_validate -0.104928278750609 0.00139735412928447 NA NA NA hsa-miR-542-3p IKBKB 0.643308814904977 8.81635403230104e-07 -0.396740795566287 2.1815201064403e-05 miRanda -0.164952079150207 8.30758678680247e-08 NA NA NA hsa-miR-107 IKBKG -0.0447040564279497 0.671618791096755 0.570547337190534 1.55778741154943e-10 miRanda -0.193473702960341 2.35749871093699e-07 NA NA NA hsa-miR-143-3p IKBKG -1.33760181792708 4.15335119989612e-12 0.570547337190534 1.55778741154943e-10 mirMAP -0.136024640433278 4.28001868046101e-12 NA NA NA hsa-miR-338-5p IKBKG -1.71946558699173 2.62649071488641e-23 0.570547337190534 1.55778741154943e-10 mirMAP -0.122404174241048 1.41142850944174e-08 NA NA NA hsa-let-7a-3p INSR 0.0966652362351867 0.423761916840503 -0.194107437746236 0.136686106038653 mirMAP -0.213874804767624 5.33683701331108e-06 NA NA NA hsa-miR-103a-2-5p INSR 1.37988337975616 6.74852943995612e-08 -0.194107437746236 0.136686106038653 mirMAP -0.185176304169939 1.72917381583809e-15 NA NA NA hsa-miR-141-3p INSR 0.730011517758706 0.000120338355004032 -0.194107437746236 0.136686106038653 mirMAP -0.164089082653693 2.41794279301179e-08 27186273 microRNA 141 inhibits thyroid cancer cell growth and metastasis by targeting insulin receptor substrate 2 metastasis thyroid cancer hsa-miR-15a-5p INSR 0.783550182002274 2.60699595655907e-11 -0.194107437746236 0.136686106038653 miRNATAP -0.330613162911114 1.4258873973789e-12 NA NA NA hsa-miR-15b-3p INSR 1.05020782493504 6.38723677324836e-14 -0.194107437746236 0.136686106038653 mirMAP -0.110818903933092 0.00519177233341178 NA NA NA hsa-miR-181b-5p INSR 0.974255518824355 2.64876280203475e-16 -0.194107437746236 0.136686106038653 mirMAP -0.161793140106989 0.000494697978258431 NA NA NA hsa-miR-205-5p INSR 1.50759485376634 2.0003886738248e-16 -0.194107437746236 0.136686106038653 mirMAP -0.249199158776933 1.17022684270028e-17 NA NA NA hsa-miR-21-5p INSR 1.62465922021121 3.44191300985109e-58 -0.194107437746236 0.136686106038653 mirMAP -0.203247220767756 5.06929122356756e-05 24804226;27220494;21618027 Downregulation of miR-21 in radioresistant NSCLC A549 cells inhibited the colony-forming ability and proliferation of A549 cells after IR; Moreover silencing miR-21 enhanced apoptosis of A549 cells induced by IR accompanied by decreased phosphorylated-Akt protein level; However PI3K activator IGF-1 reversed suppression of phosphorylated-Akt protein level and promotion of apoptosis of A549 cells after IR caused by miR-21 knockdown; Silencing miR-21 in radioresistant NSCLC A549 cells sensitized them to IR by inhibiting cell proliferation and enhancing cell apoptosis through inhibition of PI3K/Akt signaling pathway;In addition we also demonstrated that miR-21 confers decreased autophagy in cervical cancer cells after IR via the Akt-mTOR signaling pathway;In this study we found that miR-21 expression was upregulated in response to ionizing radiation IR in U251 cells which suggested that miR-21 could be involved in the response of U251 cells to radiation; We showed that a miR-21 inhibitor enhanced IR-induced glioblastoma cell growth arrest and increased the level of apoptosis which was probably caused by abrogation of the G2-M arrest induced by IR ;;drug resistance lung squamous cell cancer;cervical and endocervical cancer;glioblastoma hsa-miR-27a-3p INSR 0.348456440505425 0.00126682892514312 -0.194107437746236 0.136686106038653 miRNATAP -0.164835039787237 0.00175308822183204 NA NA NA hsa-miR-342-3p INSR 0.99756868977753 9.28499866272332e-10 -0.194107437746236 0.136686106038653 miRanda -0.185126993913913 4.99791756945346e-08 NA NA NA hsa-miR-424-5p INSR 1.48125289532143 9.10372985713165e-19 -0.194107437746236 0.136686106038653 miRNATAP -0.103497110418724 0.00156134280325816 NA NA NA hsa-miR-590-3p INSR 0.221436901462551 0.0965904764063157 -0.194107437746236 0.136686106038653 PITA;miRanda;mirMAP;miRNATAP -0.14436872279385 0.000720483868151073 NA NA NA hsa-miR-590-5p INSR 0.763025362395968 3.65305892505623e-09 -0.194107437746236 0.136686106038653 mirMAP -0.223670217758919 1.99577474916714e-07 NA NA NA hsa-miR-7-1-3p INSR 1.13646121619622 1.49823237535933e-14 -0.194107437746236 0.136686106038653 mirMAP -0.181175997957957 1.11474960466591e-06 NA NA NA hsa-miR-330-5p JMJD7-PLA2G4B 0.944693925383906 5.04972895657346e-13 -0.796367559924462 7.52402910355677e-07 miRNATAP -0.189036602989866 0.000362977794134276 NA NA NA hsa-miR-542-3p JMJD7-PLA2G4B 0.643308814904977 8.81635403230104e-07 -0.796367559924462 7.52402910355677e-07 miRNATAP -0.316324839983911 2.59499534311272e-09 NA NA NA hsa-miR-149-5p KDR 0.443278770827687 0.0642022866136881 -0.0640531132877142 0.723023281947347 miRNATAP -0.163475530932982 4.97964788050635e-07 NA NA NA hsa-miR-15a-5p KDR 0.783550182002274 2.60699595655907e-11 -0.0640531132877142 0.723023281947347 miRNATAP -0.538223224088053 4.40254709356056e-17 NA NA NA hsa-miR-15b-5p KDR 0.85315666454713 3.79816274836297e-12 -0.0640531132877142 0.723023281947347 miRNATAP -0.23138999639968 0.00022888704644937 NA NA NA hsa-miR-16-5p KDR 0.521122945828175 1.40561786410572e-06 -0.0640531132877142 0.723023281947347 miRTarBase;miRNATAP -0.251278763057448 0.000528972295280267 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-19b-1-5p KDR 0.757034032029085 2.99828133413343e-07 -0.0640531132877142 0.723023281947347 miRNAWalker2_validate -0.39505187814695 1.72509350482592e-14 NA NA NA hsa-miR-200b-3p KDR 0.0717138787925347 0.682858087587209 -0.0640531132877142 0.723023281947347 miRNAWalker2_validate;miRTarBase;TargetScan -0.263698570555775 2.67079529834483e-09 NA NA NA hsa-miR-200c-3p KDR 0.630251054099546 0.000131975031451555 -0.0640531132877142 0.723023281947347 miRNATAP -0.263590197962967 1.99844049333072e-08 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-338-3p KDR -0.948755228846395 8.99167125682392e-08 -0.0640531132877142 0.723023281947347 PITA;miRanda -0.198788405113943 4.97145669026782e-06 NA NA NA hsa-miR-429 KDR 0.559451508722375 0.00563641638673083 -0.0640531132877142 0.723023281947347 PITA;miRanda;miRNATAP -0.27245086358 7.76028904884939e-13 NA NA NA hsa-miR-455-5p KDR 1.408595672323 5.52039116456697e-22 -0.0640531132877142 0.723023281947347 PITA;miRanda;miRNATAP -0.275124811982307 7.69432624809677e-08 NA NA NA hsa-miR-590-3p KDR 0.221436901462551 0.0965904764063157 -0.0640531132877142 0.723023281947347 miRanda -0.170021217673703 0.00410155035555196 NA NA NA hsa-miR-590-5p KDR 0.763025362395968 3.65305892505623e-09 -0.0640531132877142 0.723023281947347 miRanda -0.418670351317141 1.21463513458081e-12 NA NA NA hsa-miR-664a-3p KDR -0.256108763664991 0.0513188660751664 -0.0640531132877142 0.723023281947347 mirMAP -0.192278642957014 0.00135050007055888 NA NA NA hsa-let-7a-3p KIT 0.0966652362351867 0.423761916840503 -1.94230272598042 7.66343751572674e-14 mirMAP -0.530805648762314 2.89869715124166e-08 NA NA NA hsa-miR-130a-3p KIT 0.67051191119964 4.89747518735144e-06 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.667167856595389 1.92070178758509e-18 NA NA NA hsa-miR-130b-3p KIT 1.44628430084411 9.13980959861273e-24 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.265039779940693 0.000589665049470454 NA NA NA hsa-miR-186-5p KIT 0.353452958261612 0.000145058448579496 -1.94230272598042 7.66343751572674e-14 miRNAWalker2_validate -0.467293501801696 0.000190301989939115 NA NA NA hsa-miR-193a-3p KIT 0.22120710726779 0.111827069464729 -1.94230272598042 7.66343751572674e-14 MirTarget;PITA;miRanda;miRNATAP -0.487739386439134 3.68695555599671e-09 NA NA NA hsa-miR-193b-3p KIT 1.72788400801602 3.0722151264559e-21 -1.94230272598042 7.66343751572674e-14 MirTarget;miRNATAP -0.692658869899421 1.05433951210173e-33 NA NA NA hsa-miR-19a-3p KIT 1.35800152353624 2.80940447111944e-12 -1.94230272598042 7.66343751572674e-14 miRTarBase;miRNATAP -0.571419846362028 1.47751427980055e-24 NA NA NA hsa-miR-19b-3p KIT 0.538732279378089 0.000622008277870679 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.570970952645054 1.63739914897172e-15 NA NA NA hsa-miR-205-5p KIT 1.50759485376634 2.0003886738248e-16 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.587985493295641 1.67469371567818e-23 NA NA NA hsa-miR-20a-5p KIT 1.1531986665452 1.02385132917958e-11 -1.94230272598042 7.66343751572674e-14 miRTarBase -0.594280707742389 4.7786339259645e-20 NA NA NA hsa-miR-221-3p KIT 0.410625614724387 0.000741090075261272 -1.94230272598042 7.66343751572674e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.477829275715389 4.5760842543397e-07 NA NA NA hsa-miR-222-3p KIT 1.08197052578759 2.32604040301699e-14 -1.94230272598042 7.66343751572674e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.652707534774401 4.39260036600639e-17 NA NA NA hsa-miR-301a-3p KIT 2.14132004241926 4.46255413526808e-25 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.480331192828765 9.97800204508617e-21 NA NA NA hsa-miR-338-3p KIT -0.948755228846395 8.99167125682392e-08 -1.94230272598042 7.66343751572674e-14 miRanda -0.171133051059791 0.0081865504749672 NA NA NA hsa-miR-429 KIT 0.559451508722375 0.00563641638673083 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.228014205545458 6.51900324316195e-05 NA NA NA hsa-miR-450b-5p KIT 1.25529820885833 1.18847120528666e-15 -1.94230272598042 7.66343751572674e-14 MirTarget -0.291115708652542 5.00922351814219e-05 NA NA NA hsa-miR-454-3p KIT 1.54137391927201 4.15861570449376e-20 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.517228407790827 1.64848588897275e-15 NA NA NA hsa-miR-501-5p KIT 1.02806906860218 1.63456814370548e-09 -1.94230272598042 7.66343751572674e-14 miRNATAP -0.326946873571749 1.29019266854981e-06 NA NA NA hsa-miR-505-3p KIT 0.912823669571645 4.0549774967148e-13 -1.94230272598042 7.66343751572674e-14 MirTarget;miRNATAP -0.54950302247173 7.47869762736026e-10 NA NA NA hsa-miR-671-5p KIT 1.90920358947989 6.8158317757852e-31 -1.94230272598042 7.66343751572674e-14 MirTarget -0.56193165932573 1.82858025190679e-18 NA NA NA hsa-miR-181b-5p KITLG 0.974255518824355 2.64876280203475e-16 -0.0193319950817896 0.910440302136666 MirTarget -0.205934809929244 0.000766216163444943 NA NA NA hsa-miR-186-5p KITLG 0.353452958261612 0.000145058448579496 -0.0193319950817896 0.910440302136666 mirMAP -0.274912026680401 0.000659953994959615 NA NA NA hsa-miR-19a-3p KITLG 1.35800152353624 2.80940447111944e-12 -0.0193319950817896 0.910440302136666 mirMAP -0.236370729566127 1.80207686104105e-10 NA NA NA hsa-miR-19b-3p KITLG 0.538732279378089 0.000622008277870679 -0.0193319950817896 0.910440302136666 mirMAP -0.270985426975178 7.06299179865195e-09 NA NA NA hsa-miR-205-5p KITLG 1.50759485376634 2.0003886738248e-16 -0.0193319950817896 0.910440302136666 mirMAP -0.103484329118169 0.0089552595904125 NA NA NA hsa-miR-22-5p KITLG 0.706731861922839 3.44318705980007e-07 -0.0193319950817896 0.910440302136666 MirTarget -0.208566379800274 9.19862339042177e-05 NA NA NA hsa-miR-26b-5p KITLG -0.254478038884324 0.0285227763044636 -0.0193319950817896 0.910440302136666 mirMAP -0.227552705417535 0.000423360021058634 NA NA NA hsa-miR-30b-5p KITLG -0.400238605368173 0.00346540992719245 -0.0193319950817896 0.910440302136666 mirMAP -0.149150982860689 0.00636561554116263 NA NA NA hsa-miR-30c-5p KITLG 0.021222006155897 0.886366656528128 -0.0193319950817896 0.910440302136666 mirMAP -0.201995543331669 6.02216856080911e-05 NA NA NA hsa-miR-452-3p KITLG 1.09618110917892 2.21867884261816e-07 -0.0193319950817896 0.910440302136666 mirMAP -0.117729504729521 0.000732390290750137 NA NA NA hsa-miR-501-5p KITLG 1.02806906860218 1.63456814370548e-09 -0.0193319950817896 0.910440302136666 PITA;mirMAP -0.220077381752313 4.0509381785104e-07 NA NA NA hsa-miR-589-3p KITLG 1.59559692667315 6.2886410639161e-15 -0.0193319950817896 0.910440302136666 mirMAP -0.127790628440224 0.000548131008223528 NA NA NA hsa-miR-664a-3p KITLG -0.256108763664991 0.0513188660751664 -0.0193319950817896 0.910440302136666 mirMAP -0.215610172367544 0.000152396947394066 NA NA NA hsa-let-7a-3p KRAS 0.0966652362351867 0.423761916840503 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.136931356508913 0.000135436448739821 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-miR-126-3p KRAS 0.0487843863772834 0.730130847436008 -0.0421192166497262 0.67210141138451 miRNAWalker2_validate;miRTarBase -0.115990819317181 0.0001500081257996 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK pancreatic cancer hsa-miR-155-5p KRAS 0.533437622040649 0.00248671179205372 -0.0421192166497262 0.67210141138451 miRNAWalker2_validate;miRNATAP -0.106787251340147 1.12687232356945e-05 NA NA NA hsa-miR-181a-5p KRAS 0.819060835827404 1.38616688310277e-13 -0.0421192166497262 0.67210141138451 miRNAWalker2_validate -0.206488916827338 5.30264645500736e-08 24098024;27517749;26124189 The KRAS mutational status was determined by pyrosequencing and miR-181a expression was measured by quantitative RT-PCR in CRC tumour tissue and corresponding non-neoplastic colon tissue;Here we report that miR-181a directly binds to 3'-untranslated regions UTRs; downregulates KRAS NRAS and MAPK1; and decreases AML growth; The delivery of miR-181a mimics to target AML cells using transferrin-targeting lipopolyplex nanoparticles NP increased mature miR-181a; downregulated KRAS NRAS and MAPK1; and resulted in decreased phosphorylation of the downstream RAS effectors;MiR 181a 5p inhibits cell proliferation and migration by targeting Kras in non small cell lung cancer A549 cells; Luciferase activity assay results demonstrated that two binding sites of Kras could be directly targeted by miR-181a-5p; Furthermore Kras was down-regulated by miR-181a-5p at both transcriptional and translational levels; SiRNA-mediated Kras down-regulation could mimic the effects of miR-181a-5p mimic in A549 cells; Our findings suggest that miR-181a-5p plays a potential role in tumor suppression by partially targeting Kras and has the potential therapeutic application in NSCLC patients ;; colorectal cancer;acute myeloid leukemia;lung squamous cell cancer hsa-miR-186-5p KRAS 0.353452958261612 0.000145058448579496 -0.0421192166497262 0.67210141138451 mirMAP -0.20957782293178 6.43868544074746e-06 NA NA NA hsa-miR-30a-5p KRAS -1.79779915425811 1.93360169837799e-26 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.109380981252874 6.01372957790632e-06 NA NA NA hsa-miR-30b-5p KRAS -0.400238605368173 0.00346540992719245 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.14630304008033 3.12182870258392e-06 NA NA NA hsa-miR-30c-5p KRAS 0.021222006155897 0.886366656528128 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.160986192000454 2.5135861758379e-08 22701724 Deregulated miRNAs in hereditary breast cancer revealed a role for miR 30c in regulating KRAS oncogene; In particular we experimentally validated KRAS as a miR-30c target; Luciferase assays confirmed that miR-30c binds the 3'UTR of KRAS transcripts and expression of pre-miR-30c down-regulated KRAS mRNA and protein; In addition we provide evidence that KRAS is a target of miR-30c and that this miRNA suppresses breast cancer cell growth potentially through inhibition of KRAS signaling breast cancer hsa-miR-501-3p KRAS 0.820141346319976 1.74562930463389e-08 -0.0421192166497262 0.67210141138451 MirTarget;PITA;TargetScan;miRNATAP -0.107029284719557 0.000261941382230982 NA NA NA hsa-miR-542-3p KRAS 0.643308814904977 8.81635403230104e-07 -0.0421192166497262 0.67210141138451 miRanda -0.137689698022332 2.50585208964673e-05 NA NA NA hsa-miR-132-3p KSR1 0.237841736463996 0.00653466538179383 -0.75915640764343 4.01619210965444e-08 mirMAP -0.197944303371393 0.00502293850724892 NA NA NA hsa-miR-455-5p KSR1 1.408595672323 5.52039116456697e-22 -0.75915640764343 4.01619210965444e-08 miRanda -0.238525772426593 1.65769975173239e-09 NA NA NA hsa-miR-542-3p KSR1 0.643308814904977 8.81635403230104e-07 -0.75915640764343 4.01619210965444e-08 mirMAP -0.186920257044386 5.11400754354537e-05 NA NA NA hsa-let-7a-2-3p KSR2 0.00246680275221167 0.991649532156321 -0.534254771508894 0.0888938131734096 mirMAP -0.233704406868338 7.4499727971855e-05 NA NA NA hsa-miR-139-5p KSR2 -1.46099200329485 7.85040381494472e-22 -0.534254771508894 0.0888938131734096 mirMAP -0.252922920077757 0.00343052823018287 NA NA NA hsa-miR-142-5p KSR2 0.288897753038094 0.0900009317815725 -0.534254771508894 0.0888938131734096 mirMAP -0.283505967009846 0.000411774575282055 NA NA NA hsa-miR-155-5p KSR2 0.533437622040649 0.00248671179205372 -0.534254771508894 0.0888938131734096 mirMAP -0.310706720879862 5.65542519554073e-05 NA NA NA hsa-miR-17-5p KSR2 1.41924888736771 2.75805544953758e-18 -0.534254771508894 0.0888938131734096 mirMAP -0.225654239002723 0.00556988381456821 NA NA NA hsa-miR-181b-5p KSR2 0.974255518824355 2.64876280203475e-16 -0.534254771508894 0.0888938131734096 mirMAP -0.51536212919604 3.82177501880431e-06 NA NA NA hsa-miR-186-5p KSR2 0.353452958261612 0.000145058448579496 -0.534254771508894 0.0888938131734096 mirMAP -0.486809902620237 0.000992988695422749 NA NA NA hsa-miR-18a-3p KSR2 1.82583720936229 7.51297960972179e-19 -0.534254771508894 0.0888938131734096 mirMAP -0.292245955390568 8.20832846365215e-06 NA NA NA hsa-miR-193b-5p KSR2 1.10486595354104 6.41489920661805e-11 -0.534254771508894 0.0888938131734096 mirMAP -0.586635814919543 4.38209409806508e-14 NA NA NA hsa-miR-21-5p KSR2 1.62465922021121 3.44191300985109e-58 -0.534254771508894 0.0888938131734096 mirMAP -0.420863100780629 0.000516982973174669 NA NA NA hsa-miR-22-5p KSR2 0.706731861922839 3.44318705980007e-07 -0.534254771508894 0.0888938131734096 mirMAP -0.546942711335118 1.6470070247928e-08 NA NA NA hsa-miR-223-3p KSR2 0.406538870676709 0.0488182456956297 -0.534254771508894 0.0888938131734096 mirMAP -0.343952043459053 1.63615586170779e-07 NA NA NA hsa-miR-2355-5p KSR2 1.47205546931107 8.65192179636668e-19 -0.534254771508894 0.0888938131734096 mirMAP -0.614921504355149 2.10871257231232e-15 NA NA NA hsa-miR-23a-5p KSR2 1.662156284689 7.34844237202118e-15 -0.534254771508894 0.0888938131734096 mirMAP -0.340090966622221 5.49111342454442e-08 NA NA NA hsa-miR-29a-5p KSR2 0.323252792625584 0.0370417231222825 -0.534254771508894 0.0888938131734096 mirMAP -0.450477212338143 2.76380549499579e-07 NA NA NA hsa-miR-29b-3p KSR2 -0.110721443686039 0.511264554091106 -0.534254771508894 0.0888938131734096 mirMAP -0.277284233188626 0.000645222241141342 NA NA NA hsa-miR-330-5p KSR2 0.944693925383906 5.04972895657346e-13 -0.534254771508894 0.0888938131734096 miRNATAP -0.505849789194234 6.85625951155923e-07 NA NA NA hsa-miR-342-3p KSR2 0.99756868977753 9.28499866272332e-10 -0.534254771508894 0.0888938131734096 mirMAP -0.251037329078705 0.00240513996125526 NA NA NA hsa-miR-361-3p KSR2 0.272298288982435 0.0147874880476998 -0.534254771508894 0.0888938131734096 mirMAP -0.386039708398975 0.00171676494344585 NA NA NA hsa-miR-3614-5p KSR2 0.955957969488529 2.95347675446694e-05 -0.534254771508894 0.0888938131734096 mirMAP -0.485981659502646 3.54740251442649e-17 NA NA NA hsa-miR-455-5p KSR2 1.408595672323 5.52039116456697e-22 -0.534254771508894 0.0888938131734096 mirMAP -0.579621299344344 5.88976149741555e-11 NA NA NA hsa-miR-550a-3p KSR2 1.63595944765448 5.87048146042097e-24 -0.534254771508894 0.0888938131734096 mirMAP -0.314001428472156 0.000124110184862174 NA NA NA hsa-miR-7-5p KSR2 1.55674721532755 2.41989824363914e-11 -0.534254771508894 0.0888938131734096 mirMAP -0.338800214761215 1.43913466924457e-08 NA NA NA hsa-miR-30c-5p MAP2K1 0.021222006155897 0.886366656528128 0.142764606305617 0.0590440739007102 miRNAWalker2_validate -0.10505314483532 1.85439886243956e-06 NA NA NA hsa-miR-34a-5p MAP2K1 -0.117372471043915 0.364001947180738 0.142764606305617 0.0590440739007102 miRNAWalker2_validate;miRTarBase -0.123625149360131 1.05490001381872e-06 NA NA NA hsa-let-7b-5p MAP2K2 -0.2489842756826 0.0211384499461719 -0.140639001206001 0.11730805163915 miRNAWalker2_validate -0.227132527741912 2.24643017568319e-10 NA NA NA hsa-miR-130a-3p MAPK1 0.67051191119964 4.89747518735144e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.119879003954416 4.21355197025158e-07 NA NA NA hsa-miR-140-5p MAPK1 -0.412389003031485 0.000136051708543369 -0.0253189255173565 0.755655647597946 miRanda -0.106820947603036 0.00107357303022432 NA NA NA hsa-miR-16-2-3p MAPK1 1.1567130855258 1.01867256952189e-14 -0.0253189255173565 0.755655647597946 mirMAP -0.118882902026294 1.87389146405289e-07 NA NA NA hsa-miR-19a-3p MAPK1 1.35800152353624 2.80940447111944e-12 -0.0253189255173565 0.755655647597946 mirMAP -0.108060075233242 6.73894767696324e-10 NA NA NA hsa-miR-19b-3p MAPK1 0.538732279378089 0.000622008277870679 -0.0253189255173565 0.755655647597946 mirMAP -0.153151975431285 2.83628955522989e-12 NA NA NA hsa-miR-24-1-5p MAPK1 -0.0503110566834755 0.742860080224713 -0.0253189255173565 0.755655647597946 mirMAP -0.116961525723256 3.20301669196585e-07 NA NA NA hsa-miR-29a-5p MAPK1 0.323252792625584 0.0370417231222825 -0.0253189255173565 0.755655647597946 mirMAP -0.100820598289556 8.60387631678624e-06 NA NA NA hsa-miR-29b-2-5p MAPK1 -0.502720326849742 0.000730448246894952 -0.0253189255173565 0.755655647597946 mirMAP -0.143966940664653 6.76991395724673e-10 NA NA NA hsa-miR-29b-3p MAPK1 -0.110721443686039 0.511264554091106 -0.0253189255173565 0.755655647597946 mirMAP -0.155562785937532 3.13794270245465e-14 NA NA NA hsa-miR-30b-5p MAPK1 -0.400238605368173 0.00346540992719245 -0.0253189255173565 0.755655647597946 mirMAP -0.174014396815711 6.15963591886978e-12 NA NA NA hsa-miR-30c-5p MAPK1 0.021222006155897 0.886366656528128 -0.0253189255173565 0.755655647597946 mirMAP -0.16816380351527 6.00043626518046e-13 NA NA NA hsa-miR-30d-3p MAPK1 -0.577371911152798 2.02950840095287e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.122142266216853 2.26778585246636e-05 NA NA NA hsa-miR-32-5p MAPK1 -0.317310201890053 0.0102525324475293 -0.0253189255173565 0.755655647597946 mirMAP -0.118206616474112 3.38014161673994e-05 NA NA NA hsa-miR-320a MAPK1 0.801356001806321 4.91397101474502e-09 -0.0253189255173565 0.755655647597946 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.125451646590753 6.80368047080733e-07 NA NA NA hsa-miR-338-3p MAPK1 -0.948755228846395 8.99167125682392e-08 -0.0253189255173565 0.755655647597946 miRanda -0.129835880343114 1.75257870680844e-11 NA NA NA hsa-miR-342-3p MAPK1 0.99756868977753 9.28499866272332e-10 -0.0253189255173565 0.755655647597946 miRanda;mirMAP -0.169189955454587 3.43413416819006e-16 NA NA NA hsa-miR-34a-5p MAPK1 -0.117372471043915 0.364001947180738 -0.0253189255173565 0.755655647597946 mirMAP -0.233668876576953 1.32503113597025e-18 NA NA NA hsa-miR-362-3p MAPK1 -0.697212068252854 2.61718493418184e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.110141441408008 2.93292282524057e-06 NA NA NA hsa-miR-362-5p MAPK1 0.41089772861323 0.0404254902071382 -0.0253189255173565 0.755655647597946 mirMAP -0.144103835470426 3.00694449777536e-17 NA NA NA hsa-miR-374a-3p MAPK1 -0.299190081500425 0.00682975596757891 -0.0253189255173565 0.755655647597946 mirMAP -0.110281311853038 0.000567634401408648 NA NA NA hsa-miR-374b-5p MAPK1 -0.288413933608091 0.0041474558664058 -0.0253189255173565 0.755655647597946 mirMAP -0.193539977082972 2.99670270207311e-08 NA NA NA hsa-miR-454-3p MAPK1 1.54137391927201 4.15861570449376e-20 -0.0253189255173565 0.755655647597946 mirMAP -0.134566799939584 1.33034028771569e-11 NA NA NA hsa-miR-500a-3p MAPK1 0.457959128173392 0.000691656736597067 -0.0253189255173565 0.755655647597946 mirMAP -0.181280312300052 1.44783347897454e-12 NA NA NA hsa-miR-501-3p MAPK1 0.820141346319976 1.74562930463389e-08 -0.0253189255173565 0.755655647597946 mirMAP -0.113690992046206 1.83281067549205e-06 NA NA NA hsa-miR-501-5p MAPK1 1.02806906860218 1.63456814370548e-09 -0.0253189255173565 0.755655647597946 mirMAP -0.102516454465174 5.70704874257852e-07 NA NA NA hsa-miR-502-3p MAPK1 -0.165138869760313 0.106881047403914 -0.0253189255173565 0.755655647597946 mirMAP -0.118442041096273 0.000641376645364786 NA NA NA hsa-miR-505-3p MAPK1 0.912823669571645 4.0549774967148e-13 -0.0253189255173565 0.755655647597946 mirMAP -0.112388892923579 4.07425901957411e-05 NA NA NA hsa-miR-660-5p MAPK1 -0.202705992887645 0.101093376073573 -0.0253189255173565 0.755655647597946 mirMAP -0.195287313401534 3.91978206929352e-12 NA NA NA hsa-miR-130a-3p MAPK10 0.67051191119964 4.89747518735144e-06 -0.515911722339727 0.0831884442739904 miRNATAP -0.257567155860406 0.00339348902810216 NA NA NA hsa-miR-146b-5p MAPK10 0.917975986853978 3.33749259316025e-09 -0.515911722339727 0.0831884442739904 miRanda -0.295681226115733 0.000329641658393179 NA NA NA hsa-miR-193a-3p MAPK10 0.22120710726779 0.111827069464729 -0.515911722339727 0.0831884442739904 miRanda;miRNATAP -0.493948546424074 1.00271078231064e-07 NA NA NA hsa-miR-222-3p MAPK10 1.08197052578759 2.32604040301699e-14 -0.515911722339727 0.0831884442739904 miRNATAP -0.276859620137527 0.00195454932101181 NA NA NA hsa-miR-450b-5p MAPK10 1.25529820885833 1.18847120528666e-15 -0.515911722339727 0.0831884442739904 mirMAP -0.280454869207043 0.000487914265247545 NA NA NA hsa-miR-455-5p MAPK10 1.408595672323 5.52039116456697e-22 -0.515911722339727 0.0831884442739904 miRanda -0.266609539974593 0.00177277067425019 NA NA NA hsa-miR-320b MAPK3 1.23473838180754 3.04337566045537e-14 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.150409382751881 7.4168687441981e-10 NA NA NA hsa-miR-34a-5p MAPK3 -0.117372471043915 0.364001947180738 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.142473103912921 8.01686085043296e-06 NA NA NA hsa-miR-423-3p MAPK3 1.20230884409188 2.57129723627633e-23 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.111095021124406 0.000694439178470412 NA NA NA hsa-miR-423-5p MAPK3 0.60141781325829 1.62940950644999e-07 -0.858383500175909 4.87731698141196e-21 miRNATAP -0.162814696094577 4.59419685322422e-06 NA NA NA hsa-miR-542-3p MAPK3 0.643308814904977 8.81635403230104e-07 -0.858383500175909 4.87731698141196e-21 miRanda -0.109224164762627 0.000481993746155519 NA NA NA hsa-miR-125a-5p MAPK8 0.215366061934933 0.119550904549401 -0.172407388594656 0.268657395750659 miRNAWalker2_validate -0.143608044868371 0.00350932932688087 NA NA NA hsa-miR-193b-3p MAPK8 1.72788400801602 3.0722151264559e-21 -0.172407388594656 0.268657395750659 miRNAWalker2_validate -0.103541446629706 0.00369576960582702 NA NA NA hsa-miR-301a-3p MAPK8 2.14132004241926 4.46255413526808e-25 -0.172407388594656 0.268657395750659 mirMAP -0.112933118413377 0.000284581455563168 NA NA NA hsa-miR-30b-5p MAPK8 -0.400238605368173 0.00346540992719245 -0.172407388594656 0.268657395750659 mirMAP -0.138590879277345 0.00519075072579384 NA NA NA hsa-miR-30c-5p MAPK8 0.021222006155897 0.886366656528128 -0.172407388594656 0.268657395750659 mirMAP -0.20973489202979 4.16686473002559e-06 NA NA NA hsa-miR-454-3p MAPK8 1.54137391927201 4.15861570449376e-20 -0.172407388594656 0.268657395750659 mirMAP -0.192614648253284 6.15604470021583e-07 NA NA NA hsa-miR-361-5p MAPK9 0.0803683277369505 0.314043140368058 -0.132566719441631 0.0608210268784422 miRanda -0.133370328666221 0.000635857332285973 NA NA NA hsa-miR-139-5p MET -1.46099200329485 7.85040381494472e-22 1.10982494733612 1.35440527522278e-11 miRanda -0.137911326125565 0.00274646767783672 NA NA NA hsa-miR-217 MET -1.35391381055929 2.42394951427902e-09 1.10982494733612 1.35440527522278e-11 miRanda -0.118418579913743 0.000173493783908158 NA NA NA hsa-miR-23b-3p MET -0.497563803223134 3.31483353357535e-05 1.10982494733612 1.35440527522278e-11 miRNAWalker2_validate;miRTarBase -0.346144586318372 8.24079659186336e-09 19490101 MicroRNA 23b mediates urokinase and c met downmodulation and a decreased migration of human hepatocellular carcinoma cells; In the present study to understand whether the expression of these genes might be coregulated by specific microRNAs miRs in human cells we predicted that Homo sapiens microRNA-23b could recognize two sites in the 3'-UTR of uPA and four sites in the c-met 3'-UTR by the algorithm pictar; The evidence obtained shows that overexpression of miR-23b leads to uPA and c-met downregulation and to decreased migration and proliferation abilities of HCC cells liver cancer hsa-miR-30a-3p MET -2.26144364746452 8.12421214153823e-31 1.10982494733612 1.35440527522278e-11 mirMAP -0.16920735224763 1.1418377506011e-06 NA NA NA hsa-miR-30a-5p MET -1.79779915425811 1.93360169837799e-26 1.10982494733612 1.35440527522278e-11 miRNAWalker2_validate -0.270438642104152 2.01456359758425e-11 NA NA NA hsa-miR-30d-3p MET -0.577371911152798 2.02950840095287e-06 1.10982494733612 1.35440527522278e-11 mirMAP -0.362108862532689 8.77989123375445e-10 NA NA NA hsa-miR-30e-3p MET -0.890635378639789 1.65740480611339e-16 1.10982494733612 1.35440527522278e-11 mirMAP -0.354613109014861 5.61950974192057e-08 NA NA NA hsa-miR-320a MET 0.801356001806321 4.91397101474502e-09 1.10982494733612 1.35440527522278e-11 miRNAWalker2_validate -0.147408399040599 0.00512060005516367 NA NA NA hsa-miR-34a-5p MET -0.117372471043915 0.364001947180738 1.10982494733612 1.35440527522278e-11 miRNAWalker2_validate;miRTarBase -0.431568259408799 6.1582474498291e-15 23243217;26104764;22457788;23593387;19006648;19773441;19029026 Detection of miR 34a promoter methylation in combination with elevated expression of c Met and β catenin predicts distant metastasis of colon cancer; Using a case-control study design of 94 primary colon cancer samples with and without liver metastases we determined CpG methylation frequencies of miR-34a and miR-34b/c promoters expression of miR-34a and its targets c-Met Snail and β-catenin and their prognostic value; Decreased miR-34a expression was associated with upregulation of c-Met Snail and β-catenin protein levels P = 0.031 0.132 and 0.004 which were associated with distant metastases P = 0.001 0.017 and 0.005; In a confounder-adjusted multivariate regression model miR-34a methylation high c-Met and β-catenin levels provided the most significant prognostic information about metastases to the liver P = 0.014 0.031 and 0.058 and matched pairs showed a higher prevalence of these risk factors in the samples with distant spread P = 0.029; Silencing of miR-34a and upregulation of c-Met Snail and β-catenin expression is associated with liver metastases of colon cancer; Detection of miR-34a silencing in resected primary colon cancer may be of prognostic value especially in combination with detection of c-Met and β-catenin expression;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004;c-Met is a target of miR-34a and regulates the migration and invasion of osteosarcoma cells; Osteosarcoma cells over-expressing miR-34a exhibited a significant decrease in the expression levels of c-Met mRNA and protein simultaneously; The results presented in this study demonstrated that over-expression of miR-34a could inhibit the tumor growth and metastasis of osteosarcoma probably through down regulating c-Met; And there are other putative miR-34a target genes beside c-Met which could potentially be key players in the development of osteosarcoma;Underexpression of miR 34a in hepatocellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting c MET; In addition miR-34a mimic enhanced the effect of cell proliferation inhibition and caspase activity induction of agents targeting c-MET siRNAs and small molecular inhibitor su11274;miR 34a inhibits migration and invasion by down regulation of c Met expression in human hepatocellular carcinoma cells; miR-34a directly targeted c-Met and reduced both mRNA and protein levels of c-Met; thus decreased c-Met-induced phosphorylation of extracellular signal-regulated kinases 1 and 2 ERK1/2; Taken together these results provide evidence to show the suppression role of miR-34a in tumor migration and invasion through modulation of the c-Met signaling pathway;miR-34a levels in human gliomas inversely correlated to c-Met levels measured in the same tumors; Forced expression of c-Met or Notch-1/Notch-2 transcripts lacking the 3'-untranslated region sequences partially reversed the effects of miR-34a on cell cycle arrest and cell death in glioma cells and stem cells respectively; They show that miR-34a suppresses brain tumor growth by targeting c-Met and Notch;MicroRNA 34a inhibits uveal melanoma cell proliferation and migration through downregulation of c Met; In addition expression of c-Met and cell cycle-related proteins was determined by Western blotting and immunofluorescence after the introduction of miR-34a miR-34a is actively expressed in melanocytes but not in uveal melanoma cells based on Northern blot analysis; After identification of two putative miR-34a binding sites within the 3' UTR of the human c-Met mRNA miR-34a was shown to suppress luciferase activity using HEK293 cells with a luciferase reporter construct containing the binding sites; miR-34a was confirmed to downregulate the expression of c-Met protein by Western blotting and immunofluorescence; These results demonstrate that miR-34a acts as a tumor suppressor in uveal melanoma cell proliferation and migration through the downregulation of c-Met metastasis;;metastasis;;;; colon cancer;lung cancer;sarcoma;liver cancer;liver cancer;glioblastoma;melanoma hsa-miR-362-3p MET -0.697212068252854 2.61718493418184e-06 1.10982494733612 1.35440527522278e-11 miRanda -0.143259339177905 0.00348019977924639 NA NA NA hsa-miR-374a-5p MET -0.621903385111545 6.61791773205282e-12 1.10982494733612 1.35440527522278e-11 mirMAP -0.289612089463004 0.000275595796848531 NA NA NA hsa-miR-374b-5p MET -0.288413933608091 0.0041474558664058 1.10982494733612 1.35440527522278e-11 mirMAP -0.288822027493138 7.17864715731861e-05 NA NA NA hsa-miR-664a-3p MET -0.256108763664991 0.0513188660751664 1.10982494733612 1.35440527522278e-11 mirMAP -0.215038037480857 0.000107858694717852 NA NA NA hsa-miR-103a-2-5p MRAS 1.37988337975616 6.74852943995612e-08 -0.342440778673446 0.082389718623168 mirMAP -0.206194225189353 7.78463885862847e-09 NA NA NA hsa-miR-130b-5p MRAS 1.77265255049999 1.43627774829684e-29 -0.342440778673446 0.082389718623168 mirMAP -0.184544915637701 0.000348401432904118 NA NA NA hsa-miR-135b-5p MRAS 1.5570143078477 4.60753610971455e-13 -0.342440778673446 0.082389718623168 miRNATAP -0.302311163873935 1.70822000424153e-15 NA NA NA hsa-miR-15a-5p MRAS 0.783550182002274 2.60699595655907e-11 -0.342440778673446 0.082389718623168 miRNATAP -0.311494137885706 1.4045700221351e-05 NA NA NA hsa-miR-15b-5p MRAS 0.85315666454713 3.79816274836297e-12 -0.342440778673446 0.082389718623168 miRNATAP -0.342744602619392 5.06934381233791e-07 NA NA NA hsa-miR-16-5p MRAS 0.521122945828175 1.40561786410572e-06 -0.342440778673446 0.082389718623168 miRNATAP -0.303378974653949 0.000125675331417403 NA NA NA hsa-miR-182-5p MRAS 1.15060905311096 6.25565852529946e-10 -0.342440778673446 0.082389718623168 miRNATAP -0.341668618028769 1.28080501162951e-14 NA NA NA hsa-miR-205-3p MRAS 1.2960640797621 5.80786479909147e-11 -0.342440778673446 0.082389718623168 mirMAP -0.42925916495279 3.54960170872593e-26 NA NA NA hsa-miR-29b-3p MRAS -0.110721443686039 0.511264554091106 -0.342440778673446 0.082389718623168 mirMAP -0.167183757191434 0.00105039753128202 NA NA NA hsa-miR-3065-3p MRAS -0.543069092777161 0.0213164885178151 -0.342440778673446 0.082389718623168 miRNATAP -0.240178367762243 1.73585393933944e-11 NA NA NA hsa-miR-30d-3p MRAS -0.577371911152798 2.02950840095287e-06 -0.342440778673446 0.082389718623168 mirMAP -0.194727935910175 0.0057842454154096 NA NA NA hsa-miR-324-5p MRAS 1.66709479707179 1.45961450445769e-23 -0.342440778673446 0.082389718623168 miRanda -0.278748709550101 1.07024611680967e-08 NA NA NA hsa-miR-33a-3p MRAS 0.20371038027126 0.212335697664505 -0.342440778673446 0.082389718623168 mirMAP -0.368690726645383 2.07500569098879e-12 NA NA NA hsa-miR-429 MRAS 0.559451508722375 0.00563641638673083 -0.342440778673446 0.082389718623168 miRanda;miRNATAP -0.422943115878969 1.30081340821955e-25 NA NA NA hsa-miR-582-5p MRAS -0.0366995972742474 0.821827119138923 -0.342440778673446 0.082389718623168 mirMAP -0.212815716784369 5.3127911126408e-05 NA NA NA hsa-miR-652-3p MRAS 0.358960167804889 0.00317496895411853 -0.342440778673446 0.082389718623168 miRNAWalker2_validate -0.248906342611732 0.000426081250483132 NA NA NA hsa-miR-7-1-3p MRAS 1.13646121619622 1.49823237535933e-14 -0.342440778673446 0.082389718623168 mirMAP -0.35614618909667 1.81614295376787e-10 NA NA NA hsa-miR-96-5p MRAS 1.42326703011157 4.39736150032373e-14 -0.342440778673446 0.082389718623168 TargetScan;miRNATAP -0.417398158655325 1.21247244800582e-22 NA NA NA hsa-let-7a-3p NF1 0.0966652362351867 0.423761916840503 0.202582143995177 0.0682023281367416 mirMAP -0.204565221520281 2.97421855571757e-07 NA NA NA hsa-miR-10b-5p NF1 -0.582989331935508 4.56688330655626e-06 0.202582143995177 0.0682023281367416 miRNAWalker2_validate;miRTarBase -0.232692421572101 4.41373987196264e-10 27494896 Knockdown and overexpression experiments revealed that the increase is mediated by NF1 and RhoC downstream targets of miR-10b that affect cytoskeletal dynamics through the ROCK pathway breast cancer hsa-miR-139-5p NF1 -1.46099200329485 7.85040381494472e-22 0.202582143995177 0.0682023281367416 miRanda -0.142689547780717 2.52419043095661e-06 NA NA NA hsa-miR-146b-5p NF1 0.917975986853978 3.33749259316025e-09 0.202582143995177 0.0682023281367416 miRanda -0.101517532392921 0.000939322573930778 NA NA NA hsa-miR-15a-5p NF1 0.783550182002274 2.60699595655907e-11 0.202582143995177 0.0682023281367416 MirTarget -0.290046613725367 2.74486752534918e-13 NA NA NA hsa-miR-16-1-3p NF1 0.955017760172879 5.95379292601146e-11 0.202582143995177 0.0682023281367416 MirTarget -0.141154204022266 1.39334296467952e-05 NA NA NA hsa-miR-193a-3p NF1 0.22120710726779 0.111827069464729 0.202582143995177 0.0682023281367416 miRanda -0.15302725188388 1.01911450285065e-05 NA NA NA hsa-miR-193b-3p NF1 1.72788400801602 3.0722151264559e-21 0.202582143995177 0.0682023281367416 miRNAWalker2_validate -0.115973751077598 4.41946471212787e-06 NA NA NA hsa-miR-199b-5p NF1 -1.08432682485992 7.68241801134089e-10 0.202582143995177 0.0682023281367416 miRanda -0.103150484548762 0.000126194259802808 NA NA NA hsa-miR-29a-5p NF1 0.323252792625584 0.0370417231222825 0.202582143995177 0.0682023281367416 MirTarget;miRNATAP -0.157117668501537 3.87889683736192e-07 NA NA NA hsa-miR-29b-1-5p NF1 1.39669186711325 4.36960953138935e-11 0.202582143995177 0.0682023281367416 mirMAP -0.125841233642717 1.34379204863701e-08 NA NA NA hsa-miR-30b-5p NF1 -0.400238605368173 0.00346540992719245 0.202582143995177 0.0682023281367416 MirTarget;mirMAP -0.201380053649291 7.98881698323558e-09 NA NA NA hsa-miR-30c-5p NF1 0.021222006155897 0.886366656528128 0.202582143995177 0.0682023281367416 MirTarget;mirMAP;miRNATAP -0.240438929594426 5.05599753712798e-14 NA NA NA hsa-miR-362-3p NF1 -0.697212068252854 2.61718493418184e-06 0.202582143995177 0.0682023281367416 miRanda -0.135093570028271 2.96334654425142e-05 NA NA NA hsa-miR-362-5p NF1 0.41089772861323 0.0404254902071382 0.202582143995177 0.0682023281367416 mirMAP -0.196998337465394 3.60486447739705e-17 NA NA NA hsa-miR-455-5p NF1 1.408595672323 5.52039116456697e-22 0.202582143995177 0.0682023281367416 miRanda -0.171845852250109 4.67158262719813e-08 NA NA NA hsa-miR-590-5p NF1 0.763025362395968 3.65305892505623e-09 0.202582143995177 0.0682023281367416 miRanda -0.127494302955795 0.000549385188521127 NA NA NA hsa-miR-15a-5p NFKB1 0.783550182002274 2.60699595655907e-11 -0.0586166405595643 0.532939439102198 miRNAWalker2_validate -0.100524054629175 0.00332260332322556 NA NA NA hsa-let-7c-5p NGF -2.07953368242668 3.46048888391218e-23 1.08938604562817 0.00258107261776762 MirTarget -0.474331709252181 2.09923806999807e-11 NA NA NA hsa-let-7d-5p NGF 0.481757661442508 3.66030810124939e-07 1.08938604562817 0.00258107261776762 MirTarget -0.66981065797809 5.57819243832775e-05 NA NA NA hsa-let-7g-5p NGF -0.250780249469264 0.00939610188330072 1.08938604562817 0.00258107261776762 MirTarget -1.0538459376691 8.8206138464407e-11 NA NA NA hsa-miR-320a NGF 0.801356001806321 4.91397101474502e-09 1.08938604562817 0.00258107261776762 miRanda -0.394376196453096 0.000532905541066623 NA NA NA hsa-miR-320b NGF 1.23473838180754 3.04337566045537e-14 1.08938604562817 0.00258107261776762 miRanda -0.4625048476379 9.04690456635774e-07 NA NA NA hsa-miR-423-5p NGF 0.60141781325829 1.62940950644999e-07 1.08938604562817 0.00258107261776762 MirTarget;miRNATAP -0.412248193811393 0.00259074860264355 NA NA NA hsa-miR-429 NGF 0.559451508722375 0.00563641638673083 1.08938604562817 0.00258107261776762 miRanda -0.479244868905427 4.56216629494526e-10 NA NA NA hsa-miR-145-5p NRAS -0.46917511594055 0.000685297625493134 0.398384760345124 2.73206950817875e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.127512559718541 2.02648627117484e-05 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-195-3p NRAS -0.624259620429699 0.000164279659144497 0.398384760345124 2.73206950817875e-05 mirMAP -0.105599176842807 2.41335123569666e-05 NA NA NA hsa-miR-26b-5p NRAS -0.254478038884324 0.0285227763044636 0.398384760345124 2.73206950817875e-05 mirMAP;miRNATAP -0.118342937472199 0.000985220833353607 NA NA NA hsa-miR-29b-3p NRAS -0.110721443686039 0.511264554091106 0.398384760345124 2.73206950817875e-05 miRNATAP -0.115340209430372 2.64204854445589e-06 NA NA NA hsa-miR-30e-3p NRAS -0.890635378639789 1.65740480611339e-16 0.398384760345124 2.73206950817875e-05 mirMAP -0.108551838334895 0.00387728250241298 NA NA NA hsa-miR-374a-3p NRAS -0.299190081500425 0.00682975596757891 0.398384760345124 2.73206950817875e-05 miRNATAP -0.154068780755208 4.21664914129326e-05 NA NA NA hsa-miR-374a-5p NRAS -0.621903385111545 6.61791773205282e-12 0.398384760345124 2.73206950817875e-05 mirMAP -0.130523090756999 0.00410722859636246 NA NA NA hsa-miR-374b-5p NRAS -0.288413933608091 0.0041474558664058 0.398384760345124 2.73206950817875e-05 mirMAP -0.269889320734344 4.1936925860835e-11 NA NA NA hsa-miR-664a-3p NRAS -0.256108763664991 0.0513188660751664 0.398384760345124 2.73206950817875e-05 MirTarget -0.25886236854543 4.55022879480367e-17 NA NA NA hsa-miR-142-3p NTF3 1.12754191614028 1.68798138028946e-08 -2.59170390715855 6.01062258777627e-15 miRanda -0.322747576045281 9.89154762280905e-06 NA NA NA hsa-miR-21-5p NTF3 1.62465922021121 3.44191300985109e-58 -2.59170390715855 6.01062258777627e-15 miRTarBase;miRNATAP -0.943998281374355 2.75568921736203e-13 NA NA NA hsa-miR-221-3p NTF3 0.410625614724387 0.000741090075261272 -2.59170390715855 6.01062258777627e-15 miRNATAP -0.452111562225564 0.000213183149722111 NA NA NA hsa-miR-222-3p NTF3 1.08197052578759 2.32604040301699e-14 -2.59170390715855 6.01062258777627e-15 miRNATAP -0.597619929003425 3.57843462941801e-09 NA NA NA hsa-miR-590-3p NTF3 0.221436901462551 0.0965904764063157 -2.59170390715855 6.01062258777627e-15 miRanda -0.321635739216939 0.00411542175857866 NA NA NA hsa-miR-590-5p NTF3 0.763025362395968 3.65305892505623e-09 -2.59170390715855 6.01062258777627e-15 PITA;miRanda;miRNATAP -0.359406854483493 0.0015720105948893 NA NA NA hsa-miR-125a-3p NTRK2 0.116035800853173 0.444825559956959 -1.11513528054371 0.0139689274900379 miRanda -0.441990373389826 0.000718256641505087 NA NA NA hsa-miR-142-3p NTRK2 1.12754191614028 1.68798138028946e-08 -1.11513528054371 0.0139689274900379 miRanda -0.287360686025783 0.00327565677298023 NA NA NA hsa-miR-142-5p NTRK2 0.288897753038094 0.0900009317815725 -1.11513528054371 0.0139689274900379 mirMAP -0.325271731506136 0.005197294312762 NA NA NA hsa-miR-146b-5p NTRK2 0.917975986853978 3.33749259316025e-09 -1.11513528054371 0.0139689274900379 PITA;miRanda -0.608432796014462 1.1319364914014e-06 NA NA NA hsa-miR-155-5p NTRK2 0.533437622040649 0.00248671179205372 -1.11513528054371 0.0139689274900379 mirMAP -0.290455272050116 0.00960861019429555 NA NA NA hsa-miR-181a-5p NTRK2 0.819060835827404 1.38616688310277e-13 -1.11513528054371 0.0139689274900379 mirMAP -0.631050089356719 0.000320478592136622 NA NA NA hsa-miR-181b-5p NTRK2 0.974255518824355 2.64876280203475e-16 -1.11513528054371 0.0139689274900379 mirMAP -0.988904775119714 6.54840711161066e-10 NA NA NA hsa-miR-186-5p NTRK2 0.353452958261612 0.000145058448579496 -1.11513528054371 0.0139689274900379 mirMAP -1.12885798594687 1.03540888238188e-07 NA NA NA hsa-miR-20a-3p NTRK2 1.34885093664027 2.07697464119202e-12 -1.11513528054371 0.0139689274900379 mirMAP -0.33556158712966 0.000877491532664743 NA NA NA hsa-miR-21-5p NTRK2 1.62465922021121 3.44191300985109e-58 -1.11513528054371 0.0139689274900379 mirMAP -0.5370106860942 0.00223232244493603 NA NA NA hsa-miR-22-3p NTRK2 0.00776313533473072 0.926356548861307 -1.11513528054371 0.0139689274900379 miRNATAP -0.764914528907096 0.00140748708480897 27662840 NTRK2 is an oncogene and associated with microRNA 22 regulation in human gastric cancer cell lines; The upstream regulator of NTRK2 microRNA-22 miR-22 was evaluated by dual-luciferase assay; In miR-22-upregulated MKN-28 and SNU-719 cells NTRK2 was further overexpressed to evaluate functional interaction between miR-22 and NTRK2 in GC; MiR-22 was verified to be an inverse upstream regulator of NTRK2; NTRK2 is an oncogene and reversely associated with miR-22 in regulating in vitro cancer development in GC gastric cancer hsa-miR-299-5p NTRK2 -1.92445654064493 1.52402531359074e-16 -1.11513528054371 0.0139689274900379 PITA -0.280431233884042 0.000676602024362476 NA NA NA hsa-miR-29a-5p NTRK2 0.323252792625584 0.0370417231222825 -1.11513528054371 0.0139689274900379 mirMAP -0.622411811466971 9.52438364565386e-07 NA NA NA hsa-miR-301a-3p NTRK2 2.14132004241926 4.46255413526808e-25 -1.11513528054371 0.0139689274900379 mirMAP -0.41370094338822 4.90974280092853e-06 NA NA NA hsa-miR-330-5p NTRK2 0.944693925383906 5.04972895657346e-13 -1.11513528054371 0.0139689274900379 miRanda -0.737054805452755 5.71327871260934e-07 NA NA NA hsa-miR-338-3p NTRK2 -0.948755228846395 8.99167125682392e-08 -1.11513528054371 0.0139689274900379 miRanda -0.533792504538669 1.09591550522627e-06 NA NA NA hsa-miR-339-5p NTRK2 1.07771430326938 2.45772601859307e-09 -1.11513528054371 0.0139689274900379 miRanda -0.278714184510507 0.00991541876007542 NA NA NA hsa-miR-342-3p NTRK2 0.99756868977753 9.28499866272332e-10 -1.11513528054371 0.0139689274900379 miRanda -0.532338738427602 7.79883630091174e-06 NA NA NA hsa-miR-452-3p NTRK2 1.09618110917892 2.21867884261816e-07 -1.11513528054371 0.0139689274900379 mirMAP -0.260313701493982 0.00489780827399834 NA NA NA hsa-miR-454-3p NTRK2 1.54137391927201 4.15861570449376e-20 -1.11513528054371 0.0139689274900379 mirMAP -0.504437015123473 8.16691472054223e-06 NA NA NA hsa-miR-455-3p NTRK2 2.68574446868387 4.28975903022818e-42 -1.11513528054371 0.0139689274900379 mirMAP -0.525066893090797 8.16274777713328e-09 NA NA NA hsa-miR-501-5p NTRK2 1.02806906860218 1.63456814370548e-09 -1.11513528054371 0.0139689274900379 mirMAP -0.378256345060406 0.00110146255037686 NA NA NA hsa-miR-576-5p NTRK2 0.940432050128373 6.90227595663302e-12 -1.11513528054371 0.0139689274900379 PITA;mirMAP -1.01793683008079 2.36682358426359e-13 NA NA NA hsa-miR-590-3p NTRK2 0.221436901462551 0.0965904764063157 -1.11513528054371 0.0139689274900379 PITA;miRanda;mirMAP -0.390843032150866 0.00886155311856371 NA NA NA hsa-miR-199a-5p PAK1 -0.364835768178638 0.0435119211101981 0.447978132304134 0.000120547414290664 miRanda -0.109400729243876 9.99089479586017e-05 NA NA NA hsa-miR-126-5p PAK2 -0.953529188793816 7.91719143295591e-16 0.649063820150968 2.23057345388133e-14 mirMAP -0.111227265584047 0.000363748334018261 NA NA NA hsa-miR-139-5p PAK2 -1.46099200329485 7.85040381494472e-22 0.649063820150968 2.23057345388133e-14 MirTarget;miRanda -0.172232009258379 1.90973137140248e-13 NA NA NA hsa-miR-140-3p PAK2 -0.967453553824782 7.6999446305445e-23 0.649063820150968 2.23057345388133e-14 MirTarget;PITA;miRNATAP -0.141733700937119 0.000133602038061862 NA NA NA hsa-miR-26b-5p PAK2 -0.254478038884324 0.0285227763044636 0.649063820150968 2.23057345388133e-14 MirTarget;mirMAP;miRNATAP -0.195131754336615 1.62377771314848e-09 NA NA NA hsa-miR-362-3p PAK2 -0.697212068252854 2.61718493418184e-06 0.649063820150968 2.23057345388133e-14 miRanda -0.131685946445111 1.8289272374813e-07 NA NA NA hsa-miR-500a-3p PAK2 0.457959128173392 0.000691656736597067 0.649063820150968 2.23057345388133e-14 miRNAWalker2_validate -0.116224960974462 3.19506862362859e-05 NA NA NA hsa-miR-149-5p PAK3 0.443278770827687 0.0642022866136881 -1.2693012869666 0.000137476018310493 MirTarget;miRNATAP -0.281758030062295 3.15419518959844e-06 NA NA NA hsa-miR-17-5p PAK3 1.41924888736771 2.75805544953758e-18 -1.2693012869666 0.000137476018310493 TargetScan -0.619076590705375 3.11088694131866e-13 NA NA NA hsa-miR-18a-3p PAK3 1.82583720936229 7.51297960972179e-19 -1.2693012869666 0.000137476018310493 MirTarget;miRNATAP -0.411724408085327 2.90706392044839e-09 NA NA NA hsa-miR-200b-3p PAK3 0.0717138787925347 0.682858087587209 -1.2693012869666 0.000137476018310493 TargetScan -0.398563129168679 1.45019765613009e-06 NA NA NA hsa-miR-200c-5p PAK3 0.904697667677842 1.36157973413856e-06 -1.2693012869666 0.000137476018310493 MirTarget;miRNATAP -0.392087889973709 3.0020768358388e-07 NA NA NA hsa-miR-23a-3p PAK3 0.348231698801568 6.4911858506572e-05 -1.2693012869666 0.000137476018310493 MirTarget -0.490455886598201 0.0036273452396519 NA NA NA hsa-miR-362-5p PAK3 0.41089772861323 0.0404254902071382 -1.2693012869666 0.000137476018310493 TargetScan -0.321471926606452 8.80786658776936e-06 NA NA NA hsa-miR-455-5p PAK3 1.408595672323 5.52039116456697e-22 -1.2693012869666 0.000137476018310493 miRanda -0.554178258459075 4.99784139573564e-09 NA NA NA hsa-miR-550a-3p PAK3 1.63595944765448 5.87048146042097e-24 -1.2693012869666 0.000137476018310493 MirTarget;miRNATAP -0.427172960369596 8.66663218133818e-07 NA NA NA hsa-miR-590-5p PAK3 0.763025362395968 3.65305892505623e-09 -1.2693012869666 0.000137476018310493 miRanda -0.537253438313473 1.23935175303216e-06 NA NA NA hsa-miR-96-5p PAK3 1.42326703011157 4.39736150032373e-14 -1.2693012869666 0.000137476018310493 TargetScan -0.479684008668182 1.05838203598768e-10 NA NA NA hsa-miR-130b-3p PAK6 1.44628430084411 9.13980959861273e-24 -0.271057305590491 0.0569449574570338 miRNATAP -0.121410512193984 0.00325254394861327 NA NA NA hsa-miR-423-5p PAK6 0.60141781325829 1.62940950644999e-07 -0.271057305590491 0.0569449574570338 miRNATAP -0.165457329850132 0.00205591443386508 NA NA NA hsa-miR-26b-5p PDGFB -0.254478038884324 0.0285227763044636 0.845464958577077 8.67485169100214e-08 miRNAWalker2_validate -0.172324630804419 0.00423712529201602 NA NA NA hsa-miR-29b-2-5p PDGFB -0.502720326849742 0.000730448246894952 0.845464958577077 8.67485169100214e-08 mirMAP -0.266903581406135 7.38754988734083e-09 NA NA NA hsa-miR-29b-3p PDGFB -0.110721443686039 0.511264554091106 0.845464958577077 8.67485169100214e-08 MirTarget;miRNATAP -0.160863843240162 9.73115177806472e-05 NA NA NA hsa-miR-29c-3p PDGFB -2.08166260448948 8.3238369390898e-24 0.845464958577077 8.67485169100214e-08 MirTarget;miRNATAP -0.164724591746529 2.30913539327549e-07 NA NA NA hsa-miR-342-3p PDGFB 0.99756868977753 9.28499866272332e-10 0.845464958577077 8.67485169100214e-08 miRanda -0.177362693333945 2.31239920349643e-05 NA NA NA hsa-miR-142-5p PDGFC 0.288897753038094 0.0900009317815725 -0.00261703252197343 0.990199267236464 PITA -0.18457759676812 0.000688250372045889 NA NA NA hsa-miR-16-2-3p PDGFC 1.1567130855258 1.01867256952189e-14 -0.00261703252197343 0.990199267236464 mirMAP -0.474176996283446 8.26018149592353e-16 NA NA NA hsa-miR-205-3p PDGFC 1.2960640797621 5.80786479909147e-11 -0.00261703252197343 0.990199267236464 mirMAP -0.27101775517427 2.31136634094134e-09 NA NA NA hsa-miR-335-3p PDGFC 0.336785882180547 0.0542446207938138 -0.00261703252197343 0.990199267236464 mirMAP -0.230464396095882 1.24238770167534e-05 NA NA NA hsa-miR-3607-3p PDGFC 1.01377165357363 9.13355519701165e-05 -0.00261703252197343 0.990199267236464 mirMAP -0.186371529607517 1.21414800298297e-07 NA NA NA hsa-miR-361-5p PDGFC 0.0803683277369505 0.314043140368058 -0.00261703252197343 0.990199267236464 miRanda -0.319526055516819 0.00691691231730144 NA NA NA hsa-miR-374a-3p PDGFC -0.299190081500425 0.00682975596757891 -0.00261703252197343 0.990199267236464 mirMAP -0.245258524939923 0.00359679502310855 NA NA NA hsa-miR-582-3p PDGFC -0.248056267546012 0.143798829508405 -0.00261703252197343 0.990199267236464 PITA -0.254113689314753 2.94427514642266e-06 NA NA NA hsa-miR-590-3p PDGFC 0.221436901462551 0.0965904764063157 -0.00261703252197343 0.990199267236464 PITA;miRanda;mirMAP -0.212685095241742 0.00231382570189075 NA NA NA hsa-miR-7-1-3p PDGFC 1.13646121619622 1.49823237535933e-14 -0.00261703252197343 0.990199267236464 mirMAP -0.382435034916375 2.25465436289282e-10 NA NA NA hsa-miR-19b-1-5p PDGFD 0.757034032029085 2.99828133413343e-07 -1.46202391708138 4.2355844030761e-11 MirTarget -0.511985051973844 1.82114576561545e-15 NA NA NA hsa-miR-203a-3p PDGFD 0.0441399794719697 0.880456392176704 -1.46202391708138 4.2355844030761e-11 MirTarget -0.231723998876994 1.82675481111625e-12 NA NA NA hsa-miR-21-5p PDGFD 1.62465922021121 3.44191300985109e-58 -1.46202391708138 4.2355844030761e-11 miRNAWalker2_validate -0.589602693801609 6.1971280888613e-12 NA NA NA hsa-miR-320a PDGFD 0.801356001806321 4.91397101474502e-09 -1.46202391708138 4.2355844030761e-11 miRanda -0.246731728430742 0.000505172675992749 NA NA NA hsa-miR-331-5p PDGFD 0.851618030062133 1.42670149420057e-14 -1.46202391708138 4.2355844030761e-11 MirTarget -0.585766842115598 7.9439593514765e-12 NA NA NA hsa-miR-450b-5p PDGFD 1.25529820885833 1.18847120528666e-15 -1.46202391708138 4.2355844030761e-11 mirMAP -0.171978679422097 0.00490540772794391 NA NA NA hsa-miR-590-3p PDGFD 0.221436901462551 0.0965904764063157 -1.46202391708138 4.2355844030761e-11 miRanda;mirMAP;miRNATAP -0.336744458887879 4.96058821646432e-06 NA NA NA hsa-miR-590-5p PDGFD 0.763025362395968 3.65305892505623e-09 -1.46202391708138 4.2355844030761e-11 miRanda -0.61987493834665 2.19312836316757e-17 NA NA NA hsa-miR-7-1-3p PDGFD 1.13646121619622 1.49823237535933e-14 -1.46202391708138 4.2355844030761e-11 mirMAP -0.457779796600521 6.64557064170379e-13 NA NA NA hsa-miR-944 PDGFD 1.47323925060177 2.61626403984929e-13 -1.46202391708138 4.2355844030761e-11 MirTarget;mirMAP -0.375455715589598 6.26282968164067e-16 NA NA NA hsa-let-7a-3p PDGFRA 0.0966652362351867 0.423761916840503 -0.463142743937045 0.04817832252781 mirMAP -0.529669602176716 2.68390850522982e-10 NA NA NA hsa-let-7f-1-3p PDGFRA 0.700374242293247 8.65000484720084e-08 -0.463142743937045 0.04817832252781 mirMAP -0.203048287649371 0.00882303668338635 NA NA NA hsa-let-7g-3p PDGFRA 0.637019243992294 0.000204623048574065 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.242214636780195 4.14305980343687e-05 NA NA NA hsa-miR-106a-5p PDGFRA 0.67978010057847 0.00221925869726092 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.187108191561856 4.125997505122e-05 NA NA NA hsa-miR-106b-5p PDGFRA 0.50378717276868 1.45412404526866e-05 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.279116396967218 0.00146889907846801 NA NA NA hsa-miR-130a-3p PDGFRA 0.67051191119964 4.89747518735144e-06 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.515723307874652 2.38971422139082e-14 NA NA NA hsa-miR-141-3p PDGFRA 0.730011517758706 0.000120338355004032 -0.463142743937045 0.04817832252781 MirTarget -0.505767490532425 6.91381154503213e-23 NA NA NA hsa-miR-149-5p PDGFRA 0.443278770827687 0.0642022866136881 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.173776938709491 4.23057230524602e-05 NA NA NA hsa-miR-16-1-3p PDGFRA 0.955017760172879 5.95379292601146e-11 -0.463142743937045 0.04817832252781 MirTarget -0.394960139372927 7.06855621054673e-09 NA NA NA hsa-miR-17-5p PDGFRA 1.41924888736771 2.75805544953758e-18 -0.463142743937045 0.04817832252781 MirTarget;TargetScan;miRNATAP -0.486966289383704 1.65975367184753e-16 NA NA NA hsa-miR-182-5p PDGFRA 1.15060905311096 6.25565852529946e-10 -0.463142743937045 0.04817832252781 miRNATAP -0.251226400702905 2.8736296191221e-06 NA NA NA hsa-miR-186-5p PDGFRA 0.353452958261612 0.000145058448579496 -0.463142743937045 0.04817832252781 MirTarget -0.430638628510272 9.25678657223338e-05 NA NA NA hsa-miR-193a-3p PDGFRA 0.22120710726779 0.111827069464729 -0.463142743937045 0.04817832252781 miRanda -0.385360637474971 1.31801900899795e-07 NA NA NA hsa-miR-196b-5p PDGFRA 3.78958266598891 1.12771732893771e-44 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.141611620840498 3.83240889487933e-05 NA NA NA hsa-miR-200a-3p PDGFRA 0.607140814457753 0.00289840524858752 -0.463142743937045 0.04817832252781 MirTarget -0.418556109432712 5.5401611171402e-18 NA NA NA hsa-miR-20a-5p PDGFRA 1.1531986665452 1.02385132917958e-11 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.459634108198747 1.4648906334426e-15 NA NA NA hsa-miR-224-5p PDGFRA 1.94534596857416 1.88348779207332e-19 -0.463142743937045 0.04817832252781 MirTarget -0.291603637702123 8.45665637241549e-11 NA NA NA hsa-miR-26b-5p PDGFRA -0.254478038884324 0.0285227763044636 -0.463142743937045 0.04817832252781 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.29571434460346 0.000811001382839524 NA NA NA hsa-miR-27a-3p PDGFRA 0.348456440505425 0.00126682892514312 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.399431408470765 2.36940280836809e-05 NA NA NA hsa-miR-29b-1-5p PDGFRA 1.39669186711325 4.36960953138935e-11 -0.463142743937045 0.04817832252781 mirMAP -0.310505328638843 2.6214579770892e-11 NA NA NA hsa-miR-29b-3p PDGFRA -0.110721443686039 0.511264554091106 -0.463142743937045 0.04817832252781 MirTarget -0.309199593590445 2.87491088364754e-07 NA NA NA hsa-miR-301a-3p PDGFRA 2.14132004241926 4.46255413526808e-25 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.30716680230266 2.9839566707638e-11 NA NA NA hsa-miR-320a PDGFRA 0.801356001806321 4.91397101474502e-09 -0.463142743937045 0.04817832252781 miRanda -0.256088551213152 0.000504831123583266 NA NA NA hsa-miR-320b PDGFRA 1.23473838180754 3.04337566045537e-14 -0.463142743937045 0.04817832252781 miRanda -0.236668681167249 0.000109090155715803 NA NA NA hsa-miR-330-5p PDGFRA 0.944693925383906 5.04972895657346e-13 -0.463142743937045 0.04817832252781 miRanda -0.214351710717381 0.00518115566688398 NA NA NA hsa-miR-338-3p PDGFRA -0.948755228846395 8.99167125682392e-08 -0.463142743937045 0.04817832252781 miRanda -0.159079633123343 0.00521295319497949 NA NA NA hsa-miR-339-5p PDGFRA 1.07771430326938 2.45772601859307e-09 -0.463142743937045 0.04817832252781 miRanda -0.412211810143285 3.68470566893721e-14 NA NA NA hsa-miR-33a-5p PDGFRA 1.12988965056352 3.35742517382153e-07 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.295170225755906 4.71759962730372e-11 NA NA NA hsa-miR-33b-5p PDGFRA 0.681845193600723 0.00407790722487864 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.237387453331384 5.90803903406106e-08 NA NA NA hsa-miR-342-3p PDGFRA 0.99756868977753 9.28499866272332e-10 -0.463142743937045 0.04817832252781 MirTarget;miRanda;miRNATAP -0.201117464069554 0.0011186847998832 NA NA NA hsa-miR-34a-5p PDGFRA -0.117372471043915 0.364001947180738 -0.463142743937045 0.04817832252781 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.279473416683797 0.000425575449508612 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-429 PDGFRA 0.559451508722375 0.00563641638673083 -0.463142743937045 0.04817832252781 miRanda;miRNATAP -0.3646603274658 1.47498623679927e-13 NA NA NA hsa-miR-454-3p PDGFRA 1.54137391927201 4.15861570449376e-20 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.406092239175468 1.67299803475594e-12 NA NA NA hsa-miR-455-5p PDGFRA 1.408595672323 5.52039116456697e-22 -0.463142743937045 0.04817832252781 MirTarget;PITA;miRanda -0.261429891373877 9.49351636713376e-05 NA NA NA hsa-miR-576-5p PDGFRA 0.940432050128373 6.90227595663302e-12 -0.463142743937045 0.04817832252781 mirMAP -0.48252244916662 2.04399434436523e-11 NA NA NA hsa-miR-589-3p PDGFRA 1.59559692667315 6.2886410639161e-15 -0.463142743937045 0.04817832252781 mirMAP -0.333031429734795 2.20227456353819e-11 NA NA NA hsa-miR-590-3p PDGFRA 0.221436901462551 0.0965904764063157 -0.463142743937045 0.04817832252781 miRanda;mirMAP -0.363428459817233 2.01021651672196e-06 NA NA NA hsa-miR-590-5p PDGFRA 0.763025362395968 3.65305892505623e-09 -0.463142743937045 0.04817832252781 miRanda -0.630471151401988 1.02894688811306e-16 NA NA NA hsa-miR-7-1-3p PDGFRA 1.13646121619622 1.49823237535933e-14 -0.463142743937045 0.04817832252781 mirMAP -0.470693839225208 1.10880684128766e-12 NA NA NA hsa-miR-93-5p PDGFRA 1.61042951896619 5.1280369606967e-24 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.345803927630158 1.16570780178394e-08 NA NA NA hsa-miR-944 PDGFRA 1.47323925060177 2.61626403984929e-13 -0.463142743937045 0.04817832252781 mirMAP -0.182467322614544 0.000220849656173125 NA NA NA hsa-miR-96-5p PDGFRA 1.42326703011157 4.39736150032373e-14 -0.463142743937045 0.04817832252781 TargetScan;miRNATAP -0.373700371207876 5.21978290236253e-13 NA NA NA hsa-miR-29a-3p PDGFRB -1.26881270980079 2.82496991513463e-22 1.61349776863339 3.00832890375111e-14 miRNATAP -0.252848924108258 0.0002864380072827 NA NA NA hsa-miR-29b-3p PDGFRB -0.110721443686039 0.511264554091106 1.61349776863339 3.00832890375111e-14 miRNATAP -0.381814573387718 5.66152644629818e-12 NA NA NA hsa-miR-29c-3p PDGFRB -2.08166260448948 8.3238369390898e-24 1.61349776863339 3.00832890375111e-14 miRNATAP -0.230825030507139 1.04275605654934e-07 NA NA NA hsa-miR-338-3p PDGFRB -0.948755228846395 8.99167125682392e-08 1.61349776863339 3.00832890375111e-14 miRanda -0.2824081657779 6.98566776548666e-08 NA NA NA hsa-miR-34a-5p PDGFRB -0.117372471043915 0.364001947180738 1.61349776863339 3.00832890375111e-14 MirTarget -0.416833898128444 1.12557808434585e-08 24837198 MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway metastasis gastric cancer hsa-miR-361-3p PDGFRB 0.272298288982435 0.0147874880476998 1.61349776863339 3.00832890375111e-14 MirTarget -0.245649935526185 0.00405851316554908 NA NA NA hsa-miR-664a-3p PDGFRB -0.256108763664991 0.0513188660751664 1.61349776863339 3.00832890375111e-14 MirTarget -0.201316703730783 0.00552266661901063 NA NA NA hsa-miR-9-5p PDGFRB 1.65694862043766 2.08325802567323e-05 1.61349776863339 3.00832890375111e-14 MirTarget;miRNATAP -0.101903933904259 2.25485460574598e-05 NA NA NA hsa-miR-326 PGF -0.425943992128769 0.0415010315530797 1.7894778619937 1.67156328544061e-17 mirMAP -0.157120759961536 0.000531643956578871 NA NA NA hsa-miR-335-5p PGF -1.17227779671552 1.49282618530733e-10 1.7894778619937 1.67156328544061e-17 miRNATAP -0.285425943985743 1.33410478539352e-08 NA NA NA hsa-miR-34a-5p PGF -0.117372471043915 0.364001947180738 1.7894778619937 1.67156328544061e-17 miRNATAP -0.207393986339531 0.00483382962070574 NA NA NA hsa-miR-146b-5p PIK3CA 0.917975986853978 3.33749259316025e-09 0.474083948253385 0.000138354293457267 mirMAP -0.148623698754488 1.59224953432472e-05 NA NA NA hsa-miR-17-5p PIK3CA 1.41924888736771 2.75805544953758e-18 0.474083948253385 0.000138354293457267 miRNAWalker2_validate -0.121128691188414 0.000174670602072176 NA NA NA hsa-miR-186-5p PIK3CA 0.353452958261612 0.000145058448579496 0.474083948253385 0.000138354293457267 mirMAP -0.297473635549502 3.47602075640407e-07 NA NA NA hsa-miR-29b-1-5p PIK3CA 1.39669186711325 4.36960953138935e-11 0.474083948253385 0.000138354293457267 mirMAP -0.137606426566373 3.59722935161776e-08 NA NA NA hsa-miR-320a PIK3CA 0.801356001806321 4.91397101474502e-09 0.474083948253385 0.000138354293457267 miRanda -0.175899873415021 6.70887782534591e-06 NA NA NA hsa-miR-339-5p PIK3CA 1.07771430326938 2.45772601859307e-09 0.474083948253385 0.000138354293457267 miRanda -0.140087795917754 2.01352800438963e-06 NA NA NA hsa-miR-374b-5p PIK3CA -0.288413933608091 0.0041474558664058 0.474083948253385 0.000138354293457267 mirMAP -0.251699909641235 3.33151190183606e-06 NA NA NA hsa-miR-501-5p PIK3CA 1.02806906860218 1.63456814370548e-09 0.474083948253385 0.000138354293457267 mirMAP -0.119863788285527 0.00016396438241956 NA NA NA hsa-miR-576-5p PIK3CA 0.940432050128373 6.90227595663302e-12 0.474083948253385 0.000138354293457267 PITA -0.211172584428942 4.54724446596707e-08 NA NA NA hsa-miR-582-3p PIK3CA -0.248056267546012 0.143798829508405 0.474083948253385 0.000138354293457267 miRNATAP -0.112384075179319 0.000457171976884077 NA NA NA hsa-miR-590-3p PIK3CA 0.221436901462551 0.0965904764063157 0.474083948253385 0.000138354293457267 miRanda;mirMAP -0.123785866799948 0.00253231685417896 NA NA NA hsa-miR-590-5p PIK3CA 0.763025362395968 3.65305892505623e-09 0.474083948253385 0.000138354293457267 miRanda -0.137459565446424 0.000946581823458912 NA NA NA hsa-miR-130a-3p PIK3CB 0.67051191119964 4.89747518735144e-06 -0.0830016803916331 0.377605728994098 miRNATAP -0.116910694940516 2.17993945184649e-05 NA NA NA hsa-miR-455-5p PIK3CB 1.408595672323 5.52039116456697e-22 -0.0830016803916331 0.377605728994098 miRNATAP -0.112305249746916 2.65965267643942e-05 NA NA NA hsa-miR-1468-5p PIK3CD -1.11814152104975 9.8203170781489e-10 1.09936669850841 6.53933580961931e-14 MirTarget -0.190058878065479 5.39186071979921e-08 NA NA NA hsa-miR-199a-5p PIK3CD -0.364835768178638 0.0435119211101981 1.09936669850841 6.53933580961931e-14 MirTarget;PITA;miRanda;miRNATAP -0.10392905863127 0.00413232021656056 NA NA NA hsa-miR-199b-5p PIK3CD -1.08432682485992 7.68241801134089e-10 1.09936669850841 6.53933580961931e-14 MirTarget;PITA;miRanda;miRNATAP -0.174865940346935 1.46520648745166e-06 NA NA NA hsa-miR-29c-3p PIK3CD -2.08166260448948 8.3238369390898e-24 1.09936669850841 6.53933580961931e-14 mirMAP -0.123728555182124 3.91761687692399e-05 NA NA NA hsa-miR-30a-5p PIK3CD -1.79779915425811 1.93360169837799e-26 1.09936669850841 6.53933580961931e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.215181764255274 3.32715363881856e-09 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30b-3p PIK3CD -0.338530747940815 0.0223424741180399 1.09936669850841 6.53933580961931e-14 MirTarget -0.212653512510377 1.36776424072036e-06 NA NA NA hsa-miR-30b-5p PIK3CD -0.400238605368173 0.00346540992719245 1.09936669850841 6.53933580961931e-14 MirTarget -0.248889126985861 1.5426059915817e-07 NA NA NA hsa-miR-30d-5p PIK3CD -0.38399848121878 0.000171129616944749 1.09936669850841 6.53933580961931e-14 MirTarget;miRNATAP -0.328266173808776 2.63776877258142e-07 NA NA NA hsa-miR-30e-5p PIK3CD -1.02114836019762 6.81961221797866e-17 1.09936669850841 6.53933580961931e-14 MirTarget -0.209324939899388 5.5934958220938e-05 NA NA NA hsa-miR-103a-3p PIK3R1 0.556219385347418 1.55815736455067e-09 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.399035342845615 3.61390305129075e-07 NA NA NA hsa-miR-1301-3p PIK3R1 2.13677668481885 6.11093268540831e-44 -1.21900359295309 1.01203266762174e-13 MirTarget -0.223004793710498 2.5912949051374e-07 NA NA NA hsa-miR-15a-5p PIK3R1 0.783550182002274 2.60699595655907e-11 -1.21900359295309 1.01203266762174e-13 MirTarget -0.385662977903284 1.7816116353762e-10 NA NA NA hsa-miR-15b-5p PIK3R1 0.85315666454713 3.79816274836297e-12 -1.21900359295309 1.01203266762174e-13 MirTarget -0.228618884263194 9.01523017331239e-05 NA NA NA hsa-miR-16-2-3p PIK3R1 1.1567130855258 1.01867256952189e-14 -1.21900359295309 1.01203266762174e-13 MirTarget -0.316425483424084 1.52783996282521e-11 NA NA NA hsa-miR-17-5p PIK3R1 1.41924888736771 2.75805544953758e-18 -1.21900359295309 1.01203266762174e-13 MirTarget;TargetScan;miRNATAP -0.463182517340129 2.13936557580788e-29 NA NA NA hsa-miR-182-5p PIK3R1 1.15060905311096 6.25565852529946e-10 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.244940881967473 1.25505363832818e-10 NA NA NA hsa-miR-185-5p PIK3R1 0.675225177054909 1.84953949190805e-13 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.284475955115523 0.000292942961891748 NA NA NA hsa-miR-186-5p PIK3R1 0.353452958261612 0.000145058448579496 -1.21900359295309 1.01203266762174e-13 mirMAP -0.319700116089251 4.98623038012755e-05 NA NA NA hsa-miR-188-5p PIK3R1 0.559328953885106 0.000430338888594543 -1.21900359295309 1.01203266762174e-13 MirTarget -0.160342440576419 0.000495444736297818 NA NA NA hsa-miR-200b-3p PIK3R1 0.0717138787925347 0.682858087587209 -1.21900359295309 1.01203266762174e-13 mirMAP -0.132316541375546 0.00152319590606084 NA NA NA hsa-miR-200c-3p PIK3R1 0.630251054099546 0.000131975031451555 -1.21900359295309 1.01203266762174e-13 mirMAP -0.165950070298812 0.000166005249225027 NA NA NA hsa-miR-20a-5p PIK3R1 1.1531986665452 1.02385132917958e-11 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.414035689070749 1.37700726304578e-24 NA NA NA hsa-miR-21-5p PIK3R1 1.62465922021121 3.44191300985109e-58 -1.21900359295309 1.01203266762174e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.347959293536401 6.14239978504788e-08 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 0.706731861922839 3.44318705980007e-07 -1.21900359295309 1.01203266762174e-13 mirMAP -0.186341013334501 0.000362689778770643 NA NA NA hsa-miR-222-3p PIK3R1 1.08197052578759 2.32604040301699e-14 -1.21900359295309 1.01203266762174e-13 MirTarget -0.324361920211689 6.16230355082933e-11 NA NA NA hsa-miR-224-3p PIK3R1 0.502645536188015 0.0081142387260641 -1.21900359295309 1.01203266762174e-13 mirMAP -0.120566945623901 0.00184832047796862 NA NA NA hsa-miR-29b-3p PIK3R1 -0.110721443686039 0.511264554091106 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.121645516169564 0.00518596779631768 NA NA NA hsa-miR-320a PIK3R1 0.801356001806321 4.91397101474502e-09 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.225199809648846 1.82460995490226e-05 NA NA NA hsa-miR-320b PIK3R1 1.23473838180754 3.04337566045537e-14 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.134920857869101 0.00211752860446172 NA NA NA hsa-miR-324-3p PIK3R1 0.867391246413545 3.63808540490361e-10 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRNATAP -0.177541714088148 0.000648957139596168 NA NA NA hsa-miR-424-5p PIK3R1 1.48125289532143 9.10372985713165e-19 -1.21900359295309 1.01203266762174e-13 MirTarget -0.194732317900543 3.45343462326547e-06 NA NA NA hsa-miR-429 PIK3R1 0.559451508722375 0.00563641638673083 -1.21900359295309 1.01203266762174e-13 mirMAP;miRNATAP -0.216477715044302 1.22729945836841e-09 NA NA NA hsa-miR-450b-5p PIK3R1 1.25529820885833 1.18847120528666e-15 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.182288230735551 5.59609717066614e-05 NA NA NA hsa-miR-455-3p PIK3R1 2.68574446868387 4.28975903022818e-42 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRNATAP -0.231037194203872 4.67534308068801e-12 NA NA NA hsa-miR-584-5p PIK3R1 0.458655788667031 0.0421764547676754 -1.21900359295309 1.01203266762174e-13 mirMAP -0.158511510137748 8.00515680759562e-07 NA NA NA hsa-miR-589-3p PIK3R1 1.59559692667315 6.2886410639161e-15 -1.21900359295309 1.01203266762174e-13 mirMAP -0.276889190811914 4.76785574986701e-15 NA NA NA hsa-miR-590-3p PIK3R1 0.221436901462551 0.0965904764063157 -1.21900359295309 1.01203266762174e-13 miRanda;mirMAP -0.158050349961081 0.00414021352655968 NA NA NA hsa-miR-590-5p PIK3R1 0.763025362395968 3.65305892505623e-09 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRanda;miRNATAP -0.424270969807281 7.70480985025408e-15 NA NA NA hsa-miR-629-3p PIK3R1 1.43262037314105 2.37092217984413e-19 -1.21900359295309 1.01203266762174e-13 MirTarget -0.192452582760208 1.31715256298262e-05 NA NA NA hsa-miR-93-5p PIK3R1 1.61042951896619 5.1280369606967e-24 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.348791344759735 3.1302460531533e-16 NA NA NA hsa-miR-96-5p PIK3R1 1.42326703011157 4.39736150032373e-14 -1.21900359295309 1.01203266762174e-13 TargetScan;miRNATAP -0.310953673912161 2.47412618125618e-17 NA NA NA hsa-miR-18a-3p PIK3R3 1.82583720936229 7.51297960972179e-19 -0.129019532966171 0.451055967559973 miRNAWalker2_validate -0.103240638013552 0.00398585116122596 NA NA NA hsa-miR-19a-3p PIK3R3 1.35800152353624 2.80940447111944e-12 -0.129019532966171 0.451055967559973 MirTarget;miRNATAP -0.153374017381767 4.01568767526052e-05 NA NA NA hsa-miR-19b-3p PIK3R3 0.538732279378089 0.000622008277870679 -0.129019532966171 0.451055967559973 MirTarget;miRNATAP -0.12996294371586 0.00591308278368021 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.39669186711325 4.36960953138935e-11 -0.129019532966171 0.451055967559973 mirMAP -0.137442753028623 6.48468495867568e-05 NA NA NA hsa-miR-365a-3p PIK3R3 0.446833934952926 0.00233857759218299 -0.129019532966171 0.451055967559973 MirTarget -0.431569400997508 1.46400297130903e-18 NA NA NA hsa-miR-369-3p PIK3R3 -1.2344419076994 2.66882944171146e-10 -0.129019532966171 0.451055967559973 PITA -0.105890967034452 0.00482950119317686 NA NA NA hsa-miR-589-3p PIK3R3 1.59559692667315 6.2886410639161e-15 -0.129019532966171 0.451055967559973 mirMAP -0.138465461387875 0.000168219132587265 NA NA NA hsa-miR-193a-3p PLA1A 0.22120710726779 0.111827069464729 -0.990087971295705 0.000334561183133417 miRanda -0.529868976432321 7.11347790999047e-10 NA NA NA hsa-miR-324-5p PLA1A 1.66709479707179 1.45961450445769e-23 -0.990087971295705 0.000334561183133417 miRanda -0.399319420849152 5.69150515275794e-09 NA NA NA hsa-miR-106b-5p PLA2G12A 0.50378717276868 1.45412404526866e-05 -0.773329107391423 2.43200915974282e-25 mirMAP -0.113152221403065 9.71366002804154e-05 NA NA NA hsa-miR-142-3p PLA2G12A 1.12754191614028 1.68798138028946e-08 -0.773329107391423 2.43200915974282e-25 miRanda -0.104413909705145 2.31791164239698e-10 NA NA NA hsa-miR-16-2-3p PLA2G12A 1.1567130855258 1.01867256952189e-14 -0.773329107391423 2.43200915974282e-25 mirMAP -0.127091654598804 6.02628463819818e-09 NA NA NA hsa-miR-181a-5p PLA2G12A 0.819060835827404 1.38616688310277e-13 -0.773329107391423 2.43200915974282e-25 mirMAP -0.177084446294844 2.45134089240318e-09 NA NA NA hsa-miR-181b-5p PLA2G12A 0.974255518824355 2.64876280203475e-16 -0.773329107391423 2.43200915974282e-25 mirMAP -0.16275276376844 2.98535886245717e-09 NA NA NA hsa-miR-625-3p PLA2G12A 0.0858338965684338 0.484971431380441 -0.773329107391423 2.43200915974282e-25 mirMAP -0.126989161560015 4.13953749944208e-06 NA NA NA hsa-miR-361-5p PLA2G2A 0.0803683277369505 0.314043140368058 -5.07596668469226 1.66171761681806e-23 miRanda -0.781056988805095 0.00829293149597172 NA NA NA hsa-miR-338-3p PLA2G2D -0.948755228846395 8.99167125682392e-08 1.06272215329204 0.0205348409418983 mirMAP -0.459956147027393 3.45885213943891e-05 NA NA NA hsa-miR-432-5p PLA2G2D -1.37745409934142 1.95995628572162e-09 1.06272215329204 0.0205348409418983 mirMAP -0.321939313285914 0.000173473611383924 NA NA NA hsa-miR-542-3p PLA2G2D 0.643308814904977 8.81635403230104e-07 1.06272215329204 0.0205348409418983 mirMAP -0.424558686560124 0.00526558318994375 NA NA NA hsa-miR-107 PLA2G2F -0.0447040564279497 0.671618791096755 2.39159167905521 3.03321604447909e-06 miRNATAP -1.22281290549308 9.80852928367302e-09 NA NA NA hsa-miR-125b-5p PLA2G2F -0.993460109818276 5.07736727659894e-12 2.39159167905521 3.03321604447909e-06 mirMAP -1.07055494180228 1.2079180661789e-12 NA NA NA hsa-miR-219a-1-3p PLA2G2F 0.54812960890496 0.000643480374673536 2.39159167905521 3.03321604447909e-06 MirTarget -0.816812716298986 3.53248750025489e-09 NA NA NA hsa-miR-296-5p PLA2G2F -0.425442682383961 0.0948240114267711 2.39159167905521 3.03321604447909e-06 mirMAP -0.40234344693344 7.84747912448152e-06 NA NA NA hsa-miR-324-3p PLA2G2F 0.867391246413545 3.63808540490361e-10 2.39159167905521 3.03321604447909e-06 mirMAP -0.722884962070708 5.97679176707774e-06 NA NA NA hsa-miR-326 PLA2G2F -0.425943992128769 0.0415010315530797 2.39159167905521 3.03321604447909e-06 mirMAP -0.292944760152887 0.00680257166363506 NA NA NA hsa-miR-335-5p PLA2G2F -1.17227779671552 1.49282618530733e-10 2.39159167905521 3.03321604447909e-06 mirMAP -0.745274230846876 4.10351967835558e-10 NA NA NA hsa-miR-532-5p PLA2G2F -0.021857649390892 0.830992272120134 2.39159167905521 3.03321604447909e-06 mirMAP -0.982413216365621 8.88844541055468e-06 NA NA NA hsa-let-7d-5p PLA2G3 0.481757661442508 3.66030810124939e-07 -1.55144754456764 0.000892530659625258 MirTarget -0.791725977061563 0.000234227869408305 NA NA NA hsa-let-7e-5p PLA2G3 0.0857356192778891 0.512869729833211 -1.55144754456764 0.000892530659625258 MirTarget -0.954528348111551 6.67534191858455e-10 NA NA NA hsa-let-7i-5p PLA2G3 0.249440992451337 0.00426823922424972 -1.55144754456764 0.000892530659625258 MirTarget -0.634764626341883 0.00737002608471883 NA NA NA hsa-miR-125a-3p PLA2G3 0.116035800853173 0.444825559956959 -1.55144754456764 0.000892530659625258 miRanda;miRNATAP -0.629027586265024 2.74387066358586e-06 NA NA NA hsa-miR-214-3p PLA2G3 -0.118240959890965 0.564962359782563 -1.55144754456764 0.000892530659625258 MirTarget -0.318860501519846 0.00137931064400643 NA NA NA hsa-miR-323a-3p PLA2G3 0.554923914792824 0.00856909375866133 -1.55144754456764 0.000892530659625258 MirTarget -0.453421691338451 3.55310724475585e-06 NA NA NA hsa-miR-450b-5p PLA2G3 1.25529820885833 1.18847120528666e-15 -1.55144754456764 0.000892530659625258 miRNATAP -0.797130129847432 1.75318622944739e-10 NA NA NA hsa-miR-877-5p PLA2G3 1.97571572671705 2.0032239372269e-19 -1.55144754456764 0.000892530659625258 MirTarget -0.394189129388487 4.50358237517234e-05 NA NA NA hsa-miR-146b-5p PLA2G4A 0.917975986853978 3.33749259316025e-09 -0.460609969941168 0.089725403121305 miRNAWalker2_validate -0.312706384274956 2.97197899139276e-05 NA NA NA hsa-miR-181a-5p PLA2G4A 0.819060835827404 1.38616688310277e-13 -0.460609969941168 0.089725403121305 MirTarget -0.343622076779683 0.00104992726574145 NA NA NA hsa-miR-181b-5p PLA2G4A 0.974255518824355 2.64876280203475e-16 -0.460609969941168 0.089725403121305 MirTarget -0.301620745034892 0.00186067356352167 NA NA NA hsa-miR-125a-5p PLA2G4D 0.215366061934933 0.119550904549401 -0.153373370642905 0.728117922553825 miRanda -0.375190787241568 0.00711940707559008 NA NA NA hsa-miR-34c-5p PLA2G4D 0.565896455062849 0.0224052732281715 -0.153373370642905 0.728117922553825 miRanda -0.304781681240617 7.77599059291744e-05 NA NA NA hsa-miR-432-5p PLA2G4E -1.37745409934142 1.95995628572162e-09 0.42032711661257 0.3709136444725 mirMAP -0.263208864952446 0.00272460058896533 NA NA NA hsa-miR-664a-3p PLA2G4E -0.256108763664991 0.0513188660751664 0.42032711661257 0.3709136444725 mirMAP -0.826986198627894 9.10088489695046e-08 NA NA NA hsa-miR-10a-5p PLA2G4F -0.316491613573591 0.148093857656453 -1.14478394090996 0.000389252330087777 miRNAWalker2_validate -0.254935849027333 7.41608346514559e-05 NA NA NA hsa-miR-125a-5p PLA2G4F 0.215366061934933 0.119550904549401 -1.14478394090996 0.000389252330087777 miRNAWalker2_validate -0.293872348602816 0.00415182920265261 NA NA NA hsa-miR-326 PLA2G4F -0.425943992128769 0.0415010315530797 -1.14478394090996 0.000389252330087777 miRNAWalker2_validate -0.191538700559427 0.00476481863782756 NA NA NA hsa-miR-92a-3p PLA2G4F 0.994679542307232 1.32587679156217e-16 -1.14478394090996 0.000389252330087777 miRNAWalker2_validate -0.413924966427827 0.000292263896257485 NA NA NA hsa-miR-99b-5p PLA2G4F 0.44137573438014 9.0939587647735e-05 -1.14478394090996 0.000389252330087777 miRNAWalker2_validate -0.454491124286411 0.000280774236209835 NA NA NA hsa-miR-330-5p PLA2G5 0.944693925383906 5.04972895657346e-13 -0.467636358747842 0.0620719799293586 miRanda -0.257302280936903 0.00167841807610569 NA NA NA hsa-miR-339-5p PLA2G5 1.07771430326938 2.45772601859307e-09 -0.467636358747842 0.0620719799293586 miRanda -0.268456976521455 5.82075902949895e-06 NA NA NA hsa-miR-429 PLA2G5 0.559451508722375 0.00563641638673083 -0.467636358747842 0.0620719799293586 miRanda -0.290029978513431 5.55947010592671e-08 NA NA NA hsa-miR-589-3p PLA2G5 1.59559692667315 6.2886410639161e-15 -0.467636358747842 0.0620719799293586 MirTarget -0.19760724002258 0.000253067536702086 NA NA NA hsa-miR-590-3p PLA2G5 0.221436901462551 0.0965904764063157 -0.467636358747842 0.0620719799293586 miRanda;miRNATAP -0.271782372358567 0.000946830763546805 NA NA NA hsa-miR-590-5p PLA2G5 0.763025362395968 3.65305892505623e-09 -0.467636358747842 0.0620719799293586 miRanda -0.438011814247796 1.21396823094669e-07 NA NA NA hsa-miR-185-3p PLA2G6 0.653637407906201 6.54212996668668e-05 -0.1388448067516 0.262127145301077 MirTarget -0.101887125819572 0.00185902800489636 NA NA NA hsa-miR-2355-3p PLA2G6 1.58434563546762 4.06578912176206e-18 -0.1388448067516 0.262127145301077 MirTarget -0.168200890698393 2.27529266289357e-09 NA NA NA hsa-miR-324-5p PLCE1 1.66709479707179 1.45961450445769e-23 -1.11797075968948 1.70749846850191e-05 miRanda -0.370170316943464 1.09765979574759e-08 NA NA NA hsa-miR-455-5p PLCE1 1.408595672323 5.52039116456697e-22 -1.11797075968948 1.70749846850191e-05 miRanda -0.806909059551063 5.35320354242663e-30 NA NA NA hsa-miR-96-5p PLCE1 1.42326703011157 4.39736150032373e-14 -1.11797075968948 1.70749846850191e-05 TargetScan -0.261392384263594 8.49557707902809e-06 NA NA NA hsa-miR-101-3p PLCG1 -1.91263766544878 1.50270129259053e-39 0.71662591280652 5.64973900982125e-20 miRNATAP -0.151553337202427 6.92128262971549e-12 NA NA NA hsa-miR-200b-3p PLCG1 0.0717138787925347 0.682858087587209 0.71662591280652 5.64973900982125e-20 TargetScan -0.102140424719201 3.23461890512312e-07 NA NA NA hsa-miR-34a-5p PLCG1 -0.117372471043915 0.364001947180738 0.71662591280652 5.64973900982125e-20 miRNAWalker2_validate;miRNATAP -0.10103184513093 0.000225366609484434 NA NA NA hsa-miR-125a-5p PLCG2 0.215366061934933 0.119550904549401 0.466254496043281 0.000532825814091435 miRanda -0.114996767575978 0.00709893512710981 NA NA NA hsa-miR-103a-3p PLD1 0.556219385347418 1.55815736455067e-09 -0.127927881929665 0.364050196952712 MirTarget -0.256588153443815 0.000102334416422653 NA NA NA hsa-miR-15a-5p PLD1 0.783550182002274 2.60699595655907e-11 -0.127927881929665 0.364050196952712 MirTarget -0.301783388991672 2.8072278602713e-09 NA NA NA hsa-miR-16-2-3p PLD1 1.1567130855258 1.01867256952189e-14 -0.127927881929665 0.364050196952712 mirMAP -0.124586908215077 0.00183124682706647 NA NA NA hsa-miR-16-5p PLD1 0.521122945828175 1.40561786410572e-06 -0.127927881929665 0.364050196952712 MirTarget -0.172586430907307 0.00229574900680198 NA NA NA hsa-miR-195-3p PLD1 -0.624259620429699 0.000164279659144497 -0.127927881929665 0.364050196952712 mirMAP -0.111936273826842 0.00250592449695483 NA NA NA hsa-miR-324-5p PLD1 1.66709479707179 1.45961450445769e-23 -0.127927881929665 0.364050196952712 MirTarget;miRanda;miRNATAP -0.128533472243004 0.000250633140686923 NA NA NA hsa-miR-330-5p PLD1 0.944693925383906 5.04972895657346e-13 -0.127927881929665 0.364050196952712 miRanda -0.137865695210369 0.00270547932309204 NA NA NA hsa-miR-335-3p PLD1 0.336785882180547 0.0542446207938138 -0.127927881929665 0.364050196952712 mirMAP -0.137923661688028 7.86609540985068e-05 NA NA NA hsa-miR-361-5p PLD1 0.0803683277369505 0.314043140368058 -0.127927881929665 0.364050196952712 MirTarget;miRanda -0.210705797966756 0.00707395868045598 NA NA NA hsa-miR-374a-3p PLD1 -0.299190081500425 0.00682975596757891 -0.127927881929665 0.364050196952712 MirTarget -0.350040226809014 1.75599212623662e-10 NA NA NA hsa-miR-374b-3p PLD1 0.425603499218802 0.00146686864653282 -0.127927881929665 0.364050196952712 mirMAP -0.282811073220226 4.54329583176508e-10 NA NA NA hsa-miR-409-3p PLD1 -0.342347118512604 0.0538776384301546 -0.127927881929665 0.364050196952712 MirTarget;mirMAP -0.100192003699202 0.00371255788859446 NA NA NA hsa-miR-424-5p PLD1 1.48125289532143 9.10372985713165e-19 -0.127927881929665 0.364050196952712 MirTarget -0.159936419745487 5.40773327843445e-06 NA NA NA hsa-miR-500a-5p PLD1 0.675401699376111 8.24389004707854e-05 -0.127927881929665 0.364050196952712 MirTarget -0.161200978109738 5.09987160315017e-06 NA NA NA hsa-miR-590-3p PLD1 0.221436901462551 0.0965904764063157 -0.127927881929665 0.364050196952712 PITA;miRanda;mirMAP -0.210353485080068 4.59458220826604e-06 NA NA NA hsa-miR-664a-3p PLD1 -0.256108763664991 0.0513188660751664 -0.127927881929665 0.364050196952712 mirMAP -0.168614292177895 0.00030667193094123 NA NA NA hsa-miR-671-5p PLD1 1.90920358947989 6.8158317757852e-31 -0.127927881929665 0.364050196952712 MirTarget -0.145916275297801 2.75322190034585e-05 NA NA NA hsa-miR-107 PLD2 -0.0447040564279497 0.671618791096755 -0.395660325300099 0.00293078399075494 miRanda -0.294664693468306 8.68052827498966e-08 NA NA NA hsa-let-7a-3p PRKACB 0.0966652362351867 0.423761916840503 -0.321098607006344 0.0228761424530327 MirTarget;mirMAP;miRNATAP -0.24351006648709 1.69808754515966e-06 NA NA NA hsa-let-7d-3p PRKACB 0.770676758773193 9.57945374997326e-13 -0.321098607006344 0.0228761424530327 MirTarget -0.261113668353957 2.78655698859518e-06 NA NA NA hsa-miR-141-3p PRKACB 0.730011517758706 0.000120338355004032 -0.321098607006344 0.0228761424530327 MirTarget;TargetScan;miRNATAP -0.267679710851304 1.06126331262823e-17 NA NA NA hsa-miR-16-2-3p PRKACB 1.1567130855258 1.01867256952189e-14 -0.321098607006344 0.0228761424530327 mirMAP -0.25465198696094 1.15210482297961e-10 NA NA NA hsa-miR-17-5p PRKACB 1.41924888736771 2.75805544953758e-18 -0.321098607006344 0.0228761424530327 TargetScan -0.320719783263986 1.04231465157064e-19 NA NA NA hsa-miR-182-5p PRKACB 1.15060905311096 6.25565852529946e-10 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.192126378855167 2.14564015173888e-09 NA NA NA hsa-miR-183-5p PRKACB 1.4313129319945 6.25230916431996e-14 -0.321098607006344 0.0228761424530327 MirTarget -0.193043292756991 4.67956422537156e-10 NA NA NA hsa-miR-18a-5p PRKACB 1.65455873230328 3.76457892277775e-20 -0.321098607006344 0.0228761424530327 miRNATAP -0.281434127350525 9.68681768909003e-19 NA NA NA hsa-miR-193a-3p PRKACB 0.22120710726779 0.111827069464729 -0.321098607006344 0.0228761424530327 miRanda -0.120890648652317 0.00645270297281106 NA NA NA hsa-miR-19a-3p PRKACB 1.35800152353624 2.80940447111944e-12 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.258968002486092 6.18986461469059e-18 NA NA NA hsa-miR-19b-3p PRKACB 0.538732279378089 0.000622008277870679 -0.321098607006344 0.0228761424530327 miRNAWalker2_validate;MirTarget;miRNATAP -0.335571469796732 5.37740203716601e-19 NA NA NA hsa-miR-200a-3p PRKACB 0.607140814457753 0.00289840524858752 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.241062026533704 1.65937825863575e-16 NA NA NA hsa-miR-200b-3p PRKACB 0.0717138787925347 0.682858087587209 -0.321098607006344 0.0228761424530327 MirTarget;TargetScan -0.231640096513903 1.90730092010153e-11 NA NA NA hsa-miR-200c-3p PRKACB 0.630251054099546 0.000131975031451555 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.209750443181332 1.11607954800956e-08 NA NA NA hsa-miR-30d-3p PRKACB -0.577371911152798 2.02950840095287e-06 -0.321098607006344 0.0228761424530327 mirMAP -0.229710131067783 4.74198208250703e-06 NA NA NA hsa-miR-339-5p PRKACB 1.07771430326938 2.45772601859307e-09 -0.321098607006344 0.0228761424530327 miRanda -0.226395664639244 6.08522673686748e-12 NA NA NA hsa-miR-34a-5p PRKACB -0.117372471043915 0.364001947180738 -0.321098607006344 0.0228761424530327 miRNATAP -0.188258649958631 7.8062126512609e-05 NA NA NA hsa-miR-362-5p PRKACB 0.41089772861323 0.0404254902071382 -0.321098607006344 0.0228761424530327 PITA -0.231677226283398 9.49014505345782e-15 NA NA NA hsa-miR-429 PRKACB 0.559451508722375 0.00563641638673083 -0.321098607006344 0.0228761424530327 MirTarget;PITA;miRanda;miRNATAP -0.24828232747711 3.61288238132463e-17 NA NA NA hsa-miR-532-5p PRKACB -0.021857649390892 0.830992272120134 -0.321098607006344 0.0228761424530327 PITA -0.227164270683247 0.000174154322184187 NA NA NA hsa-miR-590-5p PRKACB 0.763025362395968 3.65305892505623e-09 -0.321098607006344 0.0228761424530327 miRanda -0.305639629088135 3.88857071786905e-11 NA NA NA hsa-miR-7-1-3p PRKACB 1.13646121619622 1.49823237535933e-14 -0.321098607006344 0.0228761424530327 mirMAP -0.163214783006832 5.48095567644113e-05 NA NA NA hsa-miR-708-3p PRKACB 1.32647174389322 4.87465491977979e-16 -0.321098607006344 0.0228761424530327 mirMAP -0.239908721941593 2.49822385276827e-11 NA NA NA hsa-miR-93-5p PRKACB 1.61042951896619 5.1280369606967e-24 -0.321098607006344 0.0228761424530327 miRNAWalker2_validate -0.265261521642743 2.04882387197337e-13 NA NA NA hsa-miR-944 PRKACB 1.47323925060177 2.61626403984929e-13 -0.321098607006344 0.0228761424530327 MirTarget;mirMAP -0.138499316290303 2.90532544481091e-06 NA NA NA hsa-miR-96-5p PRKACB 1.42326703011157 4.39736150032373e-14 -0.321098607006344 0.0228761424530327 miRNATAP -0.258796730941182 5.34409541983872e-17 NA NA NA hsa-miR-103a-2-5p PRKCA 1.37988337975616 6.74852943995612e-08 0.3178322857115 0.0462170958036427 mirMAP -0.117780407567177 5.24493745308123e-05 NA NA NA hsa-miR-150-5p PRKCA -0.243749814009231 0.331546276920338 0.3178322857115 0.0462170958036427 mirMAP -0.104022182991935 0.000162874861270433 NA NA NA hsa-miR-17-3p PRKCA -0.0127974722290336 0.909559935689875 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.214761659225552 0.000540115676811066 NA NA NA hsa-miR-181c-5p PRKCA -0.168991199007857 0.196949106150297 0.3178322857115 0.0462170958036427 mirMAP -0.230481828890932 1.38543638100701e-05 NA NA NA hsa-miR-183-5p PRKCA 1.4313129319945 6.25230916431996e-14 0.3178322857115 0.0462170958036427 miRNATAP -0.123604672252822 0.000489233186271866 NA NA NA hsa-miR-186-5p PRKCA 0.353452958261612 0.000145058448579496 0.3178322857115 0.0462170958036427 miRNATAP -0.197395594611936 0.008653002308399 NA NA NA hsa-miR-1976 PRKCA 0.638808083289405 2.94840228896364e-07 0.3178322857115 0.0462170958036427 miRNATAP -0.216146135639291 9.07994360436659e-05 NA NA NA hsa-miR-19b-1-5p PRKCA 0.757034032029085 2.99828133413343e-07 0.3178322857115 0.0462170958036427 mirMAP -0.214408086876696 3.69042545103291e-06 NA NA NA hsa-miR-200b-3p PRKCA 0.0717138787925347 0.682858087587209 0.3178322857115 0.0462170958036427 TargetScan -0.341691724440131 5.17210999735547e-19 NA NA NA hsa-miR-200c-3p PRKCA 0.630251054099546 0.000131975031451555 0.3178322857115 0.0462170958036427 miRNATAP -0.258050454876613 4.38353493232271e-10 NA NA NA hsa-miR-24-2-5p PRKCA 1.27293931700635 4.48240091510596e-15 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.121435567912037 0.00357611288622236 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-27b-5p PRKCA 0.580870079022649 0.000181529223377382 0.3178322857115 0.0462170958036427 mirMAP -0.227514723686497 2.70991772299128e-07 NA NA NA hsa-miR-29b-2-5p PRKCA -0.502720326849742 0.000730448246894952 0.3178322857115 0.0462170958036427 mirMAP -0.296683337612196 9.93635847649949e-11 NA NA NA hsa-miR-30d-3p PRKCA -0.577371911152798 2.02950840095287e-06 0.3178322857115 0.0462170958036427 mirMAP -0.332961077885486 3.40360771990262e-09 NA NA NA hsa-miR-30e-3p PRKCA -0.890635378639789 1.65740480611339e-16 0.3178322857115 0.0462170958036427 mirMAP -0.199675307499267 0.00146746163627339 NA NA NA hsa-miR-339-5p PRKCA 1.07771430326938 2.45772601859307e-09 0.3178322857115 0.0462170958036427 mirMAP -0.148559462896231 8.30706937469769e-05 NA NA NA hsa-miR-3607-3p PRKCA 1.01377165357363 9.13355519701165e-05 0.3178322857115 0.0462170958036427 mirMAP -0.133480273866349 4.39877789751401e-07 NA NA NA hsa-miR-362-5p PRKCA 0.41089772861323 0.0404254902071382 0.3178322857115 0.0462170958036427 TargetScan;miRNATAP -0.223333590994173 5.47462768229892e-11 NA NA NA hsa-miR-374a-5p PRKCA -0.621903385111545 6.61791773205282e-12 0.3178322857115 0.0462170958036427 mirMAP -0.205530215602705 0.00688190144820459 NA NA NA hsa-miR-429 PRKCA 0.559451508722375 0.00563641638673083 0.3178322857115 0.0462170958036427 miRanda;miRNATAP -0.266671632635371 1.42360916592268e-15 NA NA NA hsa-miR-500a-5p PRKCA 0.675401699376111 8.24389004707854e-05 0.3178322857115 0.0462170958036427 miRNATAP -0.174713694092824 1.31490069031191e-05 NA NA NA hsa-miR-501-5p PRKCA 1.02806906860218 1.63456814370548e-09 0.3178322857115 0.0462170958036427 miRNATAP -0.164099616970046 5.18294254195767e-05 NA NA NA hsa-miR-505-5p PRKCA 1.25888458076414 7.80089782306577e-13 0.3178322857115 0.0462170958036427 mirMAP -0.108990500629565 0.00483820175668253 NA NA NA hsa-miR-532-3p PRKCA 0.80240056676907 1.08989551712617e-09 0.3178322857115 0.0462170958036427 mirMAP;miRNATAP -0.201724862387695 0.000103690896052721 NA NA NA hsa-miR-590-3p PRKCA 0.221436901462551 0.0965904764063157 0.3178322857115 0.0462170958036427 PITA;miRanda;mirMAP;miRNATAP -0.159630241178647 0.00227859309388304 NA NA NA hsa-miR-92a-3p PRKCA 0.994679542307232 1.32587679156217e-16 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.239077901540622 1.99085302915519e-05 NA NA NA hsa-miR-93-3p PRKCA 1.69225547123293 1.50964095575087e-25 0.3178322857115 0.0462170958036427 mirMAP -0.142996896050503 0.000455152507074917 NA NA NA hsa-miR-200b-3p PRKCB 0.0717138787925347 0.682858087587209 -0.00995382054367333 0.966062170170983 MirTarget -0.25314056822959 1.19976246306159e-05 NA NA NA hsa-miR-200c-3p PRKCB 0.630251054099546 0.000131975031451555 -0.00995382054367333 0.966062170170983 MirTarget;miRNATAP -0.247883706249509 5.19535947946646e-05 NA NA NA hsa-miR-205-3p PRKCB 1.2960640797621 5.80786479909147e-11 -0.00995382054367333 0.966062170170983 mirMAP -0.139761356797048 0.00563704149985681 NA NA NA hsa-miR-23a-3p PRKCB 0.348231698801568 6.4911858506572e-05 -0.00995382054367333 0.966062170170983 mirMAP -0.585222638829513 5.31039580277569e-07 NA NA NA hsa-miR-24-3p PRKCB 0.13115428390042 0.203891651275156 -0.00995382054367333 0.966062170170983 miRNATAP -0.412248047896016 3.20409690969774e-05 NA NA NA hsa-miR-27a-3p PRKCB 0.348456440505425 0.00126682892514312 -0.00995382054367333 0.966062170170983 MirTarget;miRNATAP -0.586533342240413 3.06369418405208e-10 NA NA NA hsa-miR-335-3p PRKCB 0.336785882180547 0.0542446207938138 -0.00995382054367333 0.966062170170983 mirMAP -0.150801933292581 0.00964223317290781 NA NA NA hsa-miR-338-3p PRKCB -0.948755228846395 8.99167125682392e-08 -0.00995382054367333 0.966062170170983 miRanda -0.189063660103368 0.000843153123017634 NA NA NA hsa-miR-361-5p PRKCB 0.0803683277369505 0.314043140368058 -0.00995382054367333 0.966062170170983 MirTarget;miRanda;miRNATAP -0.375874177784515 0.00379764519521529 NA NA NA hsa-miR-429 PRKCB 0.559451508722375 0.00563641638673083 -0.00995382054367333 0.966062170170983 MirTarget;miRanda;miRNATAP -0.30122694602295 1.22808222979422e-09 NA NA NA hsa-miR-450b-5p PRKCB 1.25529820885833 1.18847120528666e-15 -0.00995382054367333 0.966062170170983 miRNATAP -0.164181125995606 0.00942767159258168 NA NA NA hsa-miR-452-3p PRKCB 1.09618110917892 2.21867884261816e-07 -0.00995382054367333 0.966062170170983 mirMAP -0.288633705564416 7.41556259016727e-10 NA NA NA hsa-miR-589-3p PRKCB 1.59559692667315 6.2886410639161e-15 -0.00995382054367333 0.966062170170983 mirMAP -0.224077186704912 7.93186780188175e-06 NA NA NA hsa-miR-590-5p PRKCB 0.763025362395968 3.65305892505623e-09 -0.00995382054367333 0.966062170170983 miRanda -0.36636674657937 2.16525521339557e-06 NA NA NA hsa-miR-944 PRKCB 1.47323925060177 2.61626403984929e-13 -0.00995382054367333 0.966062170170983 mirMAP -0.228083074030307 3.27391957426865e-06 NA NA NA hsa-miR-181a-5p PTPN11 0.819060835827404 1.38616688310277e-13 -0.0515826939037778 0.576869711205509 miRNAWalker2_validate;miRTarBase -0.161608190801894 4.96220269355183e-06 NA NA NA hsa-miR-186-5p PTPN11 0.353452958261612 0.000145058448579496 -0.0515826939037778 0.576869711205509 mirMAP -0.12504435483559 0.00395247157448723 NA NA NA hsa-miR-19a-3p PTPN11 1.35800152353624 2.80940447111944e-12 -0.0515826939037778 0.576869711205509 mirMAP -0.104810580196544 1.63971779276308e-07 NA NA NA hsa-miR-19b-3p PTPN11 0.538732279378089 0.000622008277870679 -0.0515826939037778 0.576869711205509 mirMAP -0.142907034248953 1.30234193411386e-08 NA NA NA hsa-miR-30d-3p PTPN11 -0.577371911152798 2.02950840095287e-06 -0.0515826939037778 0.576869711205509 mirMAP -0.103411088631455 0.00168252066916046 NA NA NA hsa-miR-320a PTPN11 0.801356001806321 4.91397101474502e-09 -0.0515826939037778 0.576869711205509 miRNAWalker2_validate;mirMAP -0.114498649641558 7.23980225732591e-05 NA NA NA hsa-miR-374b-5p PTPN11 -0.288413933608091 0.0041474558664058 -0.0515826939037778 0.576869711205509 mirMAP -0.176786984020678 9.57788085802768e-06 NA NA NA hsa-miR-660-5p PTPN11 -0.202705992887645 0.101093376073573 -0.0515826939037778 0.576869711205509 mirMAP -0.168933026494295 1.73424994830389e-07 NA NA NA hsa-miR-130b-3p RAB5A 1.44628430084411 9.13980959861273e-24 -0.741636316730273 6.41714444857143e-19 miRNAWalker2_validate;MirTarget;miRNATAP -0.215967721635101 4.09117775189749e-19 NA NA NA hsa-miR-18a-5p RAB5A 1.65455873230328 3.76457892277775e-20 -0.741636316730273 6.41714444857143e-19 miRNAWalker2_validate;MirTarget -0.100233311495686 5.02086775459984e-07 NA NA NA hsa-miR-301a-3p RAB5A 2.14132004241926 4.46255413526808e-25 -0.741636316730273 6.41714444857143e-19 MirTarget;miRNATAP -0.108440437737499 1.86721206577343e-10 NA NA NA hsa-miR-454-3p RAB5A 1.54137391927201 4.15861570449376e-20 -0.741636316730273 6.41714444857143e-19 MirTarget;miRNATAP -0.11901470970001 2.4418988486239e-08 NA NA NA hsa-miR-106b-5p RAB5B 0.50378717276868 1.45412404526866e-05 -0.630851576774701 1.80482952130689e-19 miRNATAP -0.179563370727082 1.35442441390869e-11 NA NA NA hsa-miR-130a-3p RAB5B 0.67051191119964 4.89747518735144e-06 -0.630851576774701 1.80482952130689e-19 miRNATAP -0.125910581525577 2.12708574091962e-09 NA NA NA hsa-miR-130b-3p RAB5B 1.44628430084411 9.13980959861273e-24 -0.630851576774701 1.80482952130689e-19 miRNAWalker2_validate;miRNATAP -0.177794260741353 1.69387913314041e-18 NA NA NA hsa-miR-17-5p RAB5B 1.41924888736771 2.75805544953758e-18 -0.630851576774701 1.80482952130689e-19 miRNAWalker2_validate;TargetScan;miRNATAP -0.124366290598046 1.27974409280585e-11 NA NA NA hsa-miR-20a-5p RAB5B 1.1531986665452 1.02385132917958e-11 -0.630851576774701 1.80482952130689e-19 miRNATAP -0.103597087984528 8.36871890599595e-09 NA NA NA hsa-miR-301a-3p RAB5B 2.14132004241926 4.46255413526808e-25 -0.630851576774701 1.80482952130689e-19 miRNATAP -0.105161182593446 1.05584097594728e-13 NA NA NA hsa-miR-320a RAB5B 0.801356001806321 4.91397101474502e-09 -0.630851576774701 1.80482952130689e-19 miRanda;mirMAP -0.147568725235537 3.80964931738782e-11 NA NA NA hsa-miR-330-5p RAB5B 0.944693925383906 5.04972895657346e-13 -0.630851576774701 1.80482952130689e-19 miRNATAP -0.115436995800047 8.19307216227278e-07 NA NA NA hsa-miR-423-5p RAB5B 0.60141781325829 1.62940950644999e-07 -0.630851576774701 1.80482952130689e-19 miRNATAP -0.151600172918741 1.83457372204295e-08 NA NA NA hsa-miR-454-3p RAB5B 1.54137391927201 4.15861570449376e-20 -0.630851576774701 1.80482952130689e-19 miRNATAP -0.122615451931208 4.52394356563218e-12 NA NA NA hsa-miR-505-5p RAB5B 1.25888458076414 7.80089782306577e-13 -0.630851576774701 1.80482952130689e-19 miRNATAP -0.133630706241261 5.02240382287593e-15 NA NA NA hsa-miR-93-5p RAB5B 1.61042951896619 5.1280369606967e-24 -0.630851576774701 1.80482952130689e-19 miRNAWalker2_validate;miRNATAP -0.131688563272608 1.07865239874048e-12 NA NA NA hsa-miR-382-5p RAC1 -0.512675955239656 0.00311534081639733 0.060247613846359 0.436073210860324 MirTarget -0.110732405915093 6.53593148835981e-09 NA NA NA hsa-miR-375 RAC2 -4.24070205340868 7.48368361454041e-28 1.54722243723033 1.85515860629167e-17 miRanda -0.164694891845942 1.8370066353598e-17 NA NA NA hsa-miR-30e-3p RALA -0.890635378639789 1.65740480611339e-16 -0.0824159915933222 0.285738632625018 MirTarget;miRNATAP -0.163072886344805 5.23107468841839e-08 NA NA NA hsa-miR-374a-5p RALA -0.621903385111545 6.61791773205282e-12 -0.0824159915933222 0.285738632625018 mirMAP;miRNATAP -0.106182110315992 0.00373398896394572 NA NA NA hsa-miR-374b-5p RALA -0.288413933608091 0.0041474558664058 -0.0824159915933222 0.285738632625018 mirMAP;miRNATAP -0.148065614967906 8.8040011957426e-06 NA NA NA hsa-let-7c-5p RALB -2.07953368242668 3.46048888391218e-23 0.280658303898747 0.00625554263542786 MirTarget -0.143958884978321 5.70988701383317e-13 NA NA NA hsa-let-7d-5p RALB 0.481757661442508 3.66030810124939e-07 0.280658303898747 0.00625554263542786 MirTarget;miRNATAP -0.125939281177448 0.00768814061808218 NA NA NA hsa-let-7g-5p RALB -0.250780249469264 0.00939610188330072 0.280658303898747 0.00625554263542786 MirTarget;miRNATAP -0.21355186291178 4.2721250566794e-06 NA NA NA hsa-miR-192-5p RALB 0.380924502586635 0.00986961967409205 0.280658303898747 0.00625554263542786 MirTarget -0.104794814442015 0.000536424225382289 NA NA NA hsa-miR-30a-3p RALB -2.26144364746452 8.12421214153823e-31 0.280658303898747 0.00625554263542786 MirTarget -0.181963175574916 2.17522421367864e-18 NA NA NA hsa-miR-30b-3p RALB -0.338530747940815 0.0223424741180399 0.280658303898747 0.00625554263542786 MirTarget -0.149829407504199 6.18500348481695e-07 NA NA NA hsa-miR-30d-3p RALB -0.577371911152798 2.02950840095287e-06 0.280658303898747 0.00625554263542786 MirTarget -0.178941712076843 9.17996862703067e-07 NA NA NA hsa-miR-30e-3p RALB -0.890635378639789 1.65740480611339e-16 0.280658303898747 0.00625554263542786 MirTarget -0.297276951415813 5.50268022363034e-14 NA NA NA hsa-miR-34a-5p RALB -0.117372471043915 0.364001947180738 0.280658303898747 0.00625554263542786 miRNAWalker2_validate -0.194717082703429 1.49718933150887e-08 NA NA NA hsa-miR-374a-5p RALB -0.621903385111545 6.61791773205282e-12 0.280658303898747 0.00625554263542786 mirMAP -0.132192444641102 0.00694117520050194 NA NA NA hsa-miR-374b-5p RALB -0.288413933608091 0.0041474558664058 0.280658303898747 0.00625554263542786 mirMAP -0.185949067470563 3.02419282994366e-05 NA NA NA hsa-miR-491-5p RALB -0.541680329196715 0.00135829217561865 0.280658303898747 0.00625554263542786 miRanda -0.103382502422024 0.000175899851018603 NA NA NA hsa-miR-664a-5p RALB -0.871809752100072 1.86842520324979e-08 0.280658303898747 0.00625554263542786 MirTarget -0.151298017907499 9.29997147253139e-08 NA NA NA hsa-miR-125a-5p RALBP1 0.215366061934933 0.119550904549401 -0.0877334112897623 0.380938496738575 miRNAWalker2_validate -0.133517557357251 2.11730683836263e-05 NA NA NA hsa-miR-130b-3p RALBP1 1.44628430084411 9.13980959861273e-24 -0.0877334112897623 0.380938496738575 MirTarget;miRNATAP -0.107569414671048 0.000193541886999795 NA NA NA hsa-miR-148a-3p RALBP1 -0.428944290834563 0.00954246923521465 -0.0877334112897623 0.380938496738575 MirTarget;miRNATAP -0.121874900055905 3.0120795841549e-06 NA NA NA hsa-miR-148b-3p RALBP1 0.386859166050437 4.6728211830726e-06 -0.0877334112897623 0.380938496738575 MirTarget -0.164850737334371 0.00144212900717216 NA NA NA hsa-miR-186-5p RALBP1 0.353452958261612 0.000145058448579496 -0.0877334112897623 0.380938496738575 mirMAP -0.156014806521586 0.00089480404296719 NA NA NA hsa-miR-320a RALBP1 0.801356001806321 4.91397101474502e-09 -0.0877334112897623 0.380938496738575 miRanda -0.123564177957076 7.79381088321619e-05 NA NA NA hsa-miR-340-5p RALBP1 -0.608415693437977 4.44345153563513e-05 -0.0877334112897623 0.380938496738575 mirMAP -0.155024305273993 7.17897875265538e-08 NA NA NA hsa-miR-542-3p RALBP1 0.643308814904977 8.81635403230104e-07 -0.0877334112897623 0.380938496738575 miRanda -0.106376413693889 0.00126759487717164 NA NA NA hsa-miR-25-3p RAP1A 0.76549796417801 3.32282098247097e-11 -0.246786487812577 0.00126184977153121 mirMAP -0.183713766506326 5.5049525501694e-11 NA NA NA hsa-miR-324-5p RAP1A 1.66709479707179 1.45961450445769e-23 -0.246786487812577 0.00126184977153121 miRanda -0.100330547621404 1.19285734322161e-07 NA NA NA hsa-miR-335-3p RAP1A 0.336785882180547 0.0542446207938138 -0.246786487812577 0.00126184977153121 mirMAP -0.123830246444417 3.87374739353737e-11 NA NA NA hsa-miR-429 RAP1A 0.559451508722375 0.00563641638673083 -0.246786487812577 0.00126184977153121 miRanda -0.121275862458848 4.51324416694827e-14 NA NA NA hsa-miR-92a-3p RAP1A 0.994679542307232 1.32587679156217e-16 -0.246786487812577 0.00126184977153121 mirMAP;miRNATAP -0.184364247436964 3.46413061182987e-12 NA NA NA hsa-miR-101-3p RAP1B -1.91263766544878 1.50270129259053e-39 0.503686034143569 2.70398789015701e-09 MirTarget;miRNATAP -0.139095100476439 3.23137602956601e-09 24697700 Functional analysis of miR 101 3p and Rap1b involved in hepatitis B virus related hepatocellular carcinoma pathogenesis; In this study we reported that HBV could repress miR-101-3p by inhibiting its promoter activity and identified the potential effects of miR-101-3p on some important biological properties of HCC cells by targeting Rap1b; Down-regulation of miR-101-3p promoted cell proliferation migration and reduced apoptosis and resulted in up-regulation of Rap1b while overexpression of miR-101-3p inhibited these processes; Moreover overexpression of Rap1b was able to reverse the suppressed cell proliferation and migration mediated by miR-101-3p; Our data showed that HBV down-regulated miR-101-3p expression by inhibiting its promoter activity which resulted in up-regulation of Rap1b and down-regulation of miR-101-3p or up-regulation of Rap1b promoted proliferation and migration of HCC cells liver cancer hsa-miR-140-3p RAP1B -0.967453553824782 7.6999446305445e-23 0.503686034143569 2.70398789015701e-09 PITA;miRNATAP -0.149854193543746 4.08347955554151e-05 NA NA NA hsa-miR-27b-3p RAP1B -0.732682718863563 2.26896143573324e-09 0.503686034143569 2.70398789015701e-09 MirTarget -0.147747475130037 7.87251935836159e-07 NA NA NA hsa-miR-30d-5p RAP1B -0.38399848121878 0.000171129616944749 0.503686034143569 2.70398789015701e-09 MirTarget;miRNATAP -0.201454395241042 2.83702676239514e-08 NA NA NA hsa-miR-125a-5p RAPGEF5 0.215366061934933 0.119550904549401 -0.129307671984287 0.330468067942475 MirTarget;PITA;miRanda -0.245584879961821 2.95243272754806e-09 NA NA NA hsa-miR-17-5p RAPGEF5 1.41924888736771 2.75805544953758e-18 -0.129307671984287 0.330468067942475 TargetScan -0.12704331155298 0.000209104931556199 NA NA NA hsa-miR-186-5p RAPGEF5 0.353452958261612 0.000145058448579496 -0.129307671984287 0.330468067942475 mirMAP -0.320022862641008 2.38968966950565e-07 NA NA NA hsa-miR-193a-3p RAPGEF5 0.22120710726779 0.111827069464729 -0.129307671984287 0.330468067942475 miRanda -0.142877881631947 0.000595621119578299 NA NA NA hsa-miR-19a-3p RAPGEF5 1.35800152353624 2.80940447111944e-12 -0.129307671984287 0.330468067942475 mirMAP -0.162339124469167 1.67218606595986e-08 NA NA NA hsa-miR-19b-3p RAPGEF5 0.538732279378089 0.000622008277870679 -0.129307671984287 0.330468067942475 mirMAP -0.190722111620478 1.46523196909383e-07 NA NA NA hsa-miR-2355-5p RAPGEF5 1.47205546931107 8.65192179636668e-19 -0.129307671984287 0.330468067942475 MirTarget -0.184169052908971 2.94811170488243e-08 NA NA NA hsa-miR-29a-5p RAPGEF5 0.323252792625584 0.0370417231222825 -0.129307671984287 0.330468067942475 mirMAP -0.208110984836007 1.71855541822136e-08 NA NA NA hsa-miR-320a RAPGEF5 0.801356001806321 4.91397101474502e-09 -0.129307671984287 0.330468067942475 miRanda;mirMAP -0.118157892682567 0.00461375379272932 NA NA NA hsa-miR-450b-5p RAPGEF5 1.25529820885833 1.18847120528666e-15 -0.129307671984287 0.330468067942475 mirMAP -0.115521082695496 0.00126403364886777 NA NA NA hsa-miR-495-3p RAPGEF5 -1.47803501311999 6.88839745293927e-13 -0.129307671984287 0.330468067942475 mirMAP -0.109648502504758 6.33160130859453e-05 NA NA NA hsa-miR-576-5p RAPGEF5 0.940432050128373 6.90227595663302e-12 -0.129307671984287 0.330468067942475 MirTarget;PITA -0.238988700274663 5.16687610005891e-09 NA NA NA hsa-miR-664a-3p RAPGEF5 -0.256108763664991 0.0513188660751664 -0.129307671984287 0.330468067942475 mirMAP -0.136938926467801 0.00190364118644219 NA NA NA hsa-miR-130b-3p RASA1 1.44628430084411 9.13980959861273e-24 -0.201395100216696 0.0880260088457525 MirTarget -0.125536186034395 0.00023140558769781 NA NA NA hsa-miR-182-5p RASA1 1.15060905311096 6.25565852529946e-10 -0.201395100216696 0.0880260088457525 MirTarget;miRNATAP -0.121602832782192 6.69310313906577e-06 24600991;26126858 Hsa mir 182 downregulates RASA1 and suppresses lung squamous cell carcinoma cell proliferation; We further show that mir-182 downregulates RASA1;Hypoxia inducible MiR 182 promotes angiogenesis by targeting RASA1 in hepatocellular carcinoma; RASA1 was demonstrated as the direct target of miR-182; In addition the suppression of RASA1 phenocopied the pro-angiogenesis effects of miR-182; Besides RASA1 was also decreased in the hypoxia HCC cells while the inhibition of miR-182 partially restored the level of RASA1; Our data showed that hypoxia regulated the expression of miR-182 and RASA1 to promote HCC angiogenesis ; lung squamous cell cancer;liver cancer hsa-miR-188-5p RASA1 0.559328953885106 0.000430338888594543 -0.201395100216696 0.0880260088457525 PITA -0.12734758946746 7.92021059785717e-05 NA NA NA hsa-miR-30b-5p RASA1 -0.400238605368173 0.00346540992719245 -0.201395100216696 0.0880260088457525 MirTarget -0.161767358084959 1.49156983060018e-05 NA NA NA hsa-miR-30c-5p RASA1 0.021222006155897 0.886366656528128 -0.201395100216696 0.0880260088457525 miRNAWalker2_validate;MirTarget;miRNATAP -0.194627126292747 1.43638518143614e-08 NA NA NA hsa-miR-320a RASA1 0.801356001806321 4.91397101474502e-09 -0.201395100216696 0.0880260088457525 MirTarget;PITA;miRanda;miRNATAP -0.185402190742104 4.60744247627703e-07 NA NA NA hsa-miR-361-5p RASA1 0.0803683277369505 0.314043140368058 -0.201395100216696 0.0880260088457525 miRanda -0.324936134473172 5.76858431427009e-07 NA NA NA hsa-miR-454-3p RASA1 1.54137391927201 4.15861570449376e-20 -0.201395100216696 0.0880260088457525 MirTarget -0.111225624434347 0.000155207426429582 NA NA NA hsa-miR-590-5p RASA1 0.763025362395968 3.65305892505623e-09 -0.201395100216696 0.0880260088457525 miRNATAP -0.103932561967306 0.008192509920492 NA NA NA hsa-miR-92a-3p RASA1 0.994679542307232 1.32587679156217e-16 -0.201395100216696 0.0880260088457525 miRNAWalker2_validate -0.178193103969919 1.70046407925388e-05 NA NA NA hsa-miR-96-5p RASA1 1.42326703011157 4.39736150032373e-14 -0.201395100216696 0.0880260088457525 TargetScan;miRNATAP -0.106080528485832 6.11647241123611e-05 NA NA NA hsa-miR-141-3p RASA2 0.730011517758706 0.000120338355004032 -0.13563780086651 0.471912272909971 TargetScan -0.116888543535217 0.00656844547003129 NA NA NA hsa-miR-17-5p RASA2 1.41924888736771 2.75805544953758e-18 -0.13563780086651 0.471912272909971 TargetScan -0.210150313758388 1.49312971602003e-05 NA NA NA hsa-miR-30a-5p RASA2 -1.79779915425811 1.93360169837799e-26 -0.13563780086651 0.471912272909971 mirMAP -0.170238889323838 0.00021815984118059 NA NA NA hsa-miR-30b-5p RASA2 -0.400238605368173 0.00346540992719245 -0.13563780086651 0.471912272909971 mirMAP -0.388985822299261 4.24413370027813e-11 NA NA NA hsa-miR-30c-5p RASA2 0.021222006155897 0.886366656528128 -0.13563780086651 0.471912272909971 mirMAP -0.427788224342382 2.49362693272155e-15 NA NA NA hsa-miR-374b-5p RASA2 -0.288413933608091 0.0041474558664058 -0.13563780086651 0.471912272909971 mirMAP -0.446807835762717 3.83703894230157e-08 NA NA NA hsa-miR-589-3p RASA2 1.59559692667315 6.2886410639161e-15 -0.13563780086651 0.471912272909971 mirMAP -0.134764926187668 0.00090233285208231 NA NA NA hsa-miR-664a-3p RASA2 -0.256108763664991 0.0513188660751664 -0.13563780086651 0.471912272909971 mirMAP -0.321655055512382 2.23803121692591e-07 NA NA NA hsa-miR-708-3p RASA2 1.32647174389322 4.87465491977979e-16 -0.13563780086651 0.471912272909971 mirMAP -0.141050868128341 0.00384140323812247 NA NA NA hsa-miR-338-3p RASA3 -0.948755228846395 8.99167125682392e-08 0.618324218686866 0.000142442039477841 mirMAP -0.127744288931383 0.00126165315824233 NA NA NA hsa-miR-92a-3p RASA3 0.994679542307232 1.32587679156217e-16 0.618324218686866 0.000142442039477841 miRNAWalker2_validate -0.249415339857321 1.39485525808633e-05 NA NA NA hsa-miR-103a-2-5p RASA4 1.37988337975616 6.74852943995612e-08 -0.323215691322125 0.0200094404662846 mirMAP -0.119320840128057 2.43740192098289e-06 NA NA NA hsa-miR-141-3p RASA4 0.730011517758706 0.000120338355004032 -0.323215691322125 0.0200094404662846 mirMAP -0.252836870934033 2.5384053142818e-16 NA NA NA hsa-miR-15b-5p RASA4 0.85315666454713 3.79816274836297e-12 -0.323215691322125 0.0200094404662846 mirMAP -0.177605642803212 0.000241104149824311 NA NA NA hsa-miR-16-5p RASA4 0.521122945828175 1.40561786410572e-06 -0.323215691322125 0.0200094404662846 mirMAP -0.157990386737514 0.00475277953713707 NA NA NA hsa-miR-194-3p RASA4 0.735945243226384 8.65425299041628e-05 -0.323215691322125 0.0200094404662846 mirMAP -0.11417996629883 0.000501607560577276 NA NA NA hsa-miR-19b-1-5p RASA4 0.757034032029085 2.99828133413343e-07 -0.323215691322125 0.0200094404662846 mirMAP -0.264441574733759 3.64603233662253e-11 NA NA NA hsa-miR-200a-3p RASA4 0.607140814457753 0.00289840524858752 -0.323215691322125 0.0200094404662846 mirMAP -0.201055590126043 4.61284521176593e-12 NA NA NA hsa-miR-2355-5p RASA4 1.47205546931107 8.65192179636668e-19 -0.323215691322125 0.0200094404662846 mirMAP -0.152734601014405 1.28446676253427e-05 NA NA NA hsa-miR-320b RASA4 1.23473838180754 3.04337566045537e-14 -0.323215691322125 0.0200094404662846 miRanda -0.114334542075418 0.00165069924440479 NA NA NA hsa-miR-331-3p RASA4 0.906385914819361 4.27653809739414e-11 -0.323215691322125 0.0200094404662846 mirMAP -0.219624283882279 3.26849010088359e-07 NA NA NA hsa-miR-34c-5p RASA4 0.565896455062849 0.0224052732281715 -0.323215691322125 0.0200094404662846 miRanda -0.107660167649288 9.19886896857033e-06 NA NA NA hsa-miR-452-3p RASA4 1.09618110917892 2.21867884261816e-07 -0.323215691322125 0.0200094404662846 MirTarget -0.123293450174768 1.17624740342722e-05 NA NA NA hsa-miR-590-3p RASA4 0.221436901462551 0.0965904764063157 -0.323215691322125 0.0200094404662846 miRanda;mirMAP -0.150289995194447 0.000974173264416963 NA NA NA hsa-miR-940 RASA4 1.25303020594374 1.3005368359451e-10 -0.323215691322125 0.0200094404662846 mirMAP -0.139298412555615 5.73749435400253e-06 NA NA NA hsa-miR-125a-5p RASAL1 0.215366061934933 0.119550904549401 -1.60165360323525 1.61706665959994e-11 miRanda -0.22269877077819 0.00368221329139565 NA NA NA hsa-miR-28-5p RASAL1 -0.026996999089909 0.733047113251652 -1.60165360323525 1.61706665959994e-11 miRanda -0.85129390432363 2.14165005704789e-10 NA NA NA hsa-miR-374b-3p RASAL1 0.425603499218802 0.00146686864653282 -1.60165360323525 1.61706665959994e-11 MirTarget -0.477925747382616 1.03166278457552e-09 NA NA NA hsa-miR-421 RASAL1 0.945488088619653 2.35762398527362e-09 -1.60165360323525 1.61706665959994e-11 miRNAWalker2_validate -0.354461030930838 5.92998607050708e-08 NA NA NA hsa-miR-130a-3p RASAL2 0.67051191119964 4.89747518735144e-06 -0.623106165029537 1.69413875486803e-06 mirMAP -0.187966011267619 1.0233478972247e-06 NA NA NA hsa-miR-130b-3p RASAL2 1.44628430084411 9.13980959861273e-24 -0.623106165029537 1.69413875486803e-06 mirMAP -0.152388125017785 5.8532973793797e-05 NA NA NA hsa-miR-130b-5p RASAL2 1.77265255049999 1.43627774829684e-29 -0.623106165029537 1.69413875486803e-06 MirTarget -0.190499962361669 2.23314199621115e-08 NA NA NA hsa-miR-135b-5p RASAL2 1.5570143078477 4.60753610971455e-13 -0.623106165029537 1.69413875486803e-06 MirTarget -0.125707059509764 1.06690807563335e-06 NA NA NA hsa-miR-141-3p RASAL2 0.730011517758706 0.000120338355004032 -0.623106165029537 1.69413875486803e-06 mirMAP -0.202176609730223 6.32306620675169e-12 NA NA NA hsa-miR-155-5p RASAL2 0.533437622040649 0.00248671179205372 -0.623106165029537 1.69413875486803e-06 MirTarget -0.167809863270317 1.67687241030946e-07 NA NA NA hsa-miR-181a-5p RASAL2 0.819060835827404 1.38616688310277e-13 -0.623106165029537 1.69413875486803e-06 mirMAP -0.261642183429477 1.98599288324777e-07 NA NA NA hsa-miR-181b-5p RASAL2 0.974255518824355 2.64876280203475e-16 -0.623106165029537 1.69413875486803e-06 mirMAP -0.204653135521904 1.15124979049823e-05 NA NA NA hsa-miR-181c-5p RASAL2 -0.168991199007857 0.196949106150297 -0.623106165029537 1.69413875486803e-06 mirMAP -0.175365620532232 6.04670782569146e-05 NA NA NA hsa-miR-186-5p RASAL2 0.353452958261612 0.000145058448579496 -0.623106165029537 1.69413875486803e-06 mirMAP -0.369688775698167 1.3835913641762e-09 NA NA NA hsa-miR-200a-3p RASAL2 0.607140814457753 0.00289840524858752 -0.623106165029537 1.69413875486803e-06 mirMAP -0.184914253403481 1.72711990523321e-11 NA NA NA hsa-miR-200b-3p RASAL2 0.0717138787925347 0.682858087587209 -0.623106165029537 1.69413875486803e-06 mirMAP -0.148318819707253 4.9055590140551e-06 NA NA NA hsa-miR-200c-3p RASAL2 0.630251054099546 0.000131975031451555 -0.623106165029537 1.69413875486803e-06 mirMAP -0.153280139867426 8.15559291781456e-06 NA NA NA hsa-miR-20a-3p RASAL2 1.34885093664027 2.07697464119202e-12 -0.623106165029537 1.69413875486803e-06 mirMAP -0.143903156381555 6.59571301869215e-07 NA NA NA hsa-miR-26b-5p RASAL2 -0.254478038884324 0.0285227763044636 -0.623106165029537 1.69413875486803e-06 miRNAWalker2_validate -0.209099233607106 2.18866935000619e-05 NA NA NA hsa-miR-29b-1-5p RASAL2 1.39669186711325 4.36960953138935e-11 -0.623106165029537 1.69413875486803e-06 MirTarget -0.106237530182819 5.80003683994255e-05 NA NA NA hsa-miR-29b-3p RASAL2 -0.110721443686039 0.511264554091106 -0.623106165029537 1.69413875486803e-06 MirTarget -0.192604220729974 1.01262274813491e-08 NA NA NA hsa-miR-301a-3p RASAL2 2.14132004241926 4.46255413526808e-25 -0.623106165029537 1.69413875486803e-06 mirMAP -0.196193459478696 2.23161295338468e-14 NA NA NA hsa-miR-30d-3p RASAL2 -0.577371911152798 2.02950840095287e-06 -0.623106165029537 1.69413875486803e-06 mirMAP -0.157111705561372 0.000809587498935992 NA NA NA hsa-miR-339-5p RASAL2 1.07771430326938 2.45772601859307e-09 -0.623106165029537 1.69413875486803e-06 PITA -0.224467543421193 1.90343788343622e-13 NA NA NA hsa-miR-3607-3p RASAL2 1.01377165357363 9.13355519701165e-05 -0.623106165029537 1.69413875486803e-06 mirMAP -0.128826584263273 2.7066483866499e-09 NA NA NA hsa-miR-361-5p RASAL2 0.0803683277369505 0.314043140368058 -0.623106165029537 1.69413875486803e-06 mirMAP -0.277286601204941 0.00013806139538121 NA NA NA hsa-miR-374a-3p RASAL2 -0.299190081500425 0.00682975596757891 -0.623106165029537 1.69413875486803e-06 mirMAP -0.198130925135919 0.000131806354632427 NA NA NA hsa-miR-374b-5p RASAL2 -0.288413933608091 0.0041474558664058 -0.623106165029537 1.69413875486803e-06 mirMAP -0.287610374785764 4.07177556695694e-07 NA NA NA hsa-miR-429 RASAL2 0.559451508722375 0.00563641638673083 -0.623106165029537 1.69413875486803e-06 mirMAP -0.163978954720164 4.08101491413155e-09 NA NA NA hsa-miR-589-3p RASAL2 1.59559692667315 6.2886410639161e-15 -0.623106165029537 1.69413875486803e-06 MirTarget -0.139189052931249 7.45105895945391e-07 NA NA NA hsa-miR-590-3p RASAL2 0.221436901462551 0.0965904764063157 -0.623106165029537 1.69413875486803e-06 MirTarget;miRanda;mirMAP -0.176492642049169 3.91674931154577e-05 NA NA NA hsa-miR-590-5p RASAL2 0.763025362395968 3.65305892505623e-09 -0.623106165029537 1.69413875486803e-06 MirTarget;miRanda -0.252119469655478 5.39996592621072e-09 NA NA NA hsa-miR-625-5p RASAL2 0.346770617079364 0.02860843739549 -0.623106165029537 1.69413875486803e-06 MirTarget -0.100523171024031 0.0057219025009495 NA NA NA hsa-miR-664a-3p RASAL2 -0.256108763664991 0.0513188660751664 -0.623106165029537 1.69413875486803e-06 mirMAP -0.20359005897921 2.72314116262702e-06 NA NA NA hsa-miR-92a-3p RASAL2 0.994679542307232 1.32587679156217e-16 -0.623106165029537 1.69413875486803e-06 miRNAWalker2_validate -0.307305392461096 1.51250541867768e-11 NA NA NA hsa-miR-942-5p RASAL2 0.678652135586536 2.58063518495056e-07 -0.623106165029537 1.69413875486803e-06 MirTarget -0.184627321970837 1.6803986710185e-05 NA NA NA hsa-let-7a-3p RASGRF2 0.0966652362351867 0.423761916840503 0.324230751966138 0.133235108703901 mirMAP -0.410714281286419 1.21583504683995e-07 NA NA NA hsa-miR-103a-2-5p RASGRF2 1.37988337975616 6.74852943995612e-08 0.324230751966138 0.133235108703901 mirMAP -0.251354621472508 1.1056716557037e-10 NA NA NA hsa-miR-106a-5p RASGRF2 0.67978010057847 0.00221925869726092 0.324230751966138 0.133235108703901 MirTarget -0.228326682382584 4.49367163166671e-08 NA NA NA hsa-miR-106b-5p RASGRF2 0.50378717276868 1.45412404526866e-05 0.324230751966138 0.133235108703901 MirTarget -0.248955631217454 0.00205988954364205 NA NA NA hsa-miR-17-5p RASGRF2 1.41924888736771 2.75805544953758e-18 0.324230751966138 0.133235108703901 MirTarget;TargetScan -0.488564331657432 1.49502419848785e-19 NA NA NA hsa-miR-182-5p RASGRF2 1.15060905311096 6.25565852529946e-10 0.324230751966138 0.133235108703901 mirMAP -0.290269368207463 3.4011332527012e-09 NA NA NA hsa-miR-20a-5p RASGRF2 1.1531986665452 1.02385132917958e-11 0.324230751966138 0.133235108703901 MirTarget -0.501625420583642 9.00291453560826e-22 NA NA NA hsa-miR-20b-5p RASGRF2 0.345967670847176 0.232014828043601 0.324230751966138 0.133235108703901 MirTarget -0.139679287700864 1.56104858414913e-05 NA NA NA hsa-miR-224-5p RASGRF2 1.94534596857416 1.88348779207332e-19 0.324230751966138 0.133235108703901 MirTarget -0.217967983106302 1.6432135265845e-07 NA NA NA hsa-miR-30d-3p RASGRF2 -0.577371911152798 2.02950840095287e-06 0.324230751966138 0.133235108703901 mirMAP -0.441016336173537 7.5554536808255e-09 NA NA NA hsa-miR-320a RASGRF2 0.801356001806321 4.91397101474502e-09 0.324230751966138 0.133235108703901 miRNATAP -0.248126839621469 0.000248526632757874 NA NA NA hsa-miR-324-5p RASGRF2 1.66709479707179 1.45961450445769e-23 0.324230751966138 0.133235108703901 miRNATAP -0.28739310284641 7.66501495935615e-08 NA NA NA hsa-miR-429 RASGRF2 0.559451508722375 0.00563641638673083 0.324230751966138 0.133235108703901 miRanda -0.424036108795227 2.26454474893344e-21 NA NA NA hsa-miR-590-3p RASGRF2 0.221436901462551 0.0965904764063157 0.324230751966138 0.133235108703901 MirTarget;miRanda -0.322579157378026 4.66177810769808e-06 NA NA NA hsa-miR-590-5p RASGRF2 0.763025362395968 3.65305892505623e-09 0.324230751966138 0.133235108703901 miRanda -0.535738748439942 2.43343780813432e-14 NA NA NA hsa-miR-708-3p RASGRF2 1.32647174389322 4.87465491977979e-16 0.324230751966138 0.133235108703901 mirMAP -0.148994120167179 0.00776809745987868 NA NA NA hsa-miR-93-5p RASGRF2 1.61042951896619 5.1280369606967e-24 0.324230751966138 0.133235108703901 MirTarget -0.339208435609099 1.10841154379648e-09 NA NA NA hsa-let-7d-5p RASGRP1 0.481757661442508 3.66030810124939e-07 -0.693551864053453 0.00413750396041983 MirTarget;miRNATAP -0.381971352308728 0.000604211187569194 NA NA NA hsa-let-7e-5p RASGRP1 0.0857356192778891 0.512869729833211 -0.693551864053453 0.00413750396041983 MirTarget;miRNATAP -0.408366090446792 3.81049997521249e-07 NA NA NA hsa-miR-154-3p RASGRP1 -0.459792546252935 0.0321099561293489 -0.693551864053453 0.00413750396041983 TargetScan -0.2333133973102 2.66945407225292e-06 NA NA NA hsa-miR-2355-3p RASGRP1 1.58434563546762 4.06578912176206e-18 -0.693551864053453 0.00413750396041983 MirTarget -0.348951401965968 2.44182759586472e-10 NA NA NA hsa-miR-320a RASGRP1 0.801356001806321 4.91397101474502e-09 -0.693551864053453 0.00413750396041983 miRanda -0.328292880725096 1.51877947346679e-05 NA NA NA hsa-miR-320b RASGRP1 1.23473838180754 3.04337566045537e-14 -0.693551864053453 0.00413750396041983 miRanda -0.21383389753746 0.00073703529913144 NA NA NA hsa-miR-655-3p RASGRP1 -1.15004187025356 3.60771552708797e-07 -0.693551864053453 0.00413750396041983 MirTarget -0.282601974940596 2.34188808175581e-09 NA NA NA hsa-miR-758-3p RASGRP1 -0.570329021195882 0.00789852529051916 -0.693551864053453 0.00413750396041983 MirTarget -0.2675253550604 3.78088187865205e-08 NA NA NA hsa-miR-324-3p RASGRP2 0.867391246413545 3.63808540490361e-10 -0.06026749303297 0.766162029378666 PITA -0.312705054301872 5.27233363939369e-07 NA NA NA hsa-miR-940 RASGRP2 1.25303020594374 1.3005368359451e-10 -0.06026749303297 0.766162029378666 MirTarget;PITA;miRNATAP -0.167672162742247 0.000185302602869422 NA NA NA hsa-miR-324-3p RASGRP3 0.867391246413545 3.63808540490361e-10 0.105424976730751 0.483961995570109 MirTarget -0.173913580069719 0.000187789114749438 NA NA NA hsa-miR-339-5p RASGRP3 1.07771430326938 2.45772601859307e-09 0.105424976730751 0.483961995570109 miRanda -0.209035783578357 3.076277048874e-09 NA NA NA hsa-miR-34c-5p RASGRP3 0.565896455062849 0.0224052732281715 0.105424976730751 0.483961995570109 miRanda -0.117969236700385 6.99079823554623e-06 NA NA NA hsa-miR-365a-3p RASGRP3 0.446833934952926 0.00233857759218299 0.105424976730751 0.483961995570109 MirTarget -0.212191413199659 1.66253545543494e-06 NA NA NA hsa-miR-589-3p RASGRP3 1.59559692667315 6.2886410639161e-15 0.105424976730751 0.483961995570109 mirMAP -0.156188734452918 1.25409996159763e-06 NA NA NA hsa-miR-590-5p RASGRP3 0.763025362395968 3.65305892505623e-09 0.105424976730751 0.483961995570109 miRanda -0.246689036945685 6.96632571495631e-07 NA NA NA hsa-miR-944 RASGRP3 1.47323925060177 2.61626403984929e-13 0.105424976730751 0.483961995570109 mirMAP -0.221284046759543 1.1436309702845e-12 NA NA NA hsa-miR-744-5p RASSF1 0.436098372735845 0.000850400989351181 0.00285478368132441 0.978255545134834 miRNAWalker2_validate -0.26433223459779 6.88963464002493e-15 NA NA NA hsa-miR-125a-5p RASSF5 0.215366061934933 0.119550904549401 -1.0863855053388 4.40896052968076e-15 miRanda -0.189662284655537 2.27408531713992e-05 NA NA NA hsa-miR-193b-3p RASSF5 1.72788400801602 3.0722151264559e-21 -1.0863855053388 4.40896052968076e-15 miRNAWalker2_validate -0.225743621556692 1.65681315021217e-12 NA NA NA hsa-miR-320a RASSF5 0.801356001806321 4.91397101474502e-09 -1.0863855053388 4.40896052968076e-15 miRanda -0.130110623192051 0.00364081662689835 NA NA NA hsa-miR-339-5p RASSF5 1.07771430326938 2.45772601859307e-09 -1.0863855053388 4.40896052968076e-15 miRanda -0.127889886168274 0.000148213082235274 NA NA NA hsa-miR-3913-5p RASSF5 0.48532077857571 0.00112373589405304 -1.0863855053388 4.40896052968076e-15 mirMAP -0.138476139504184 0.000894232224026814 NA NA NA hsa-miR-409-5p RASSF5 0.491285368786351 0.0165413843067426 -1.0863855053388 4.40896052968076e-15 PITA -0.176115521916606 3.78476542155291e-09 NA NA NA hsa-miR-421 RASSF5 0.945488088619653 2.35762398527362e-09 -1.0863855053388 4.40896052968076e-15 miRanda -0.181765640099172 2.31811894320826e-06 NA NA NA hsa-miR-450b-5p RASSF5 1.25529820885833 1.18847120528666e-15 -1.0863855053388 4.40896052968076e-15 PITA -0.328998984172984 9.99741975770783e-19 NA NA NA hsa-miR-542-3p RASSF5 0.643308814904977 8.81635403230104e-07 -1.0863855053388 4.40896052968076e-15 miRanda -0.404924585813514 6.16972417135939e-19 NA NA NA hsa-miR-576-5p RASSF5 0.940432050128373 6.90227595663302e-12 -1.0863855053388 4.40896052968076e-15 mirMAP -0.149188387393068 0.000774386176039078 NA NA NA hsa-miR-125a-5p REL 0.215366061934933 0.119550904549401 0.0560392702629682 0.788938932942294 miRanda -0.462652887608332 9.01042316347952e-13 NA NA NA hsa-miR-16-1-3p REL 0.955017760172879 5.95379292601146e-11 0.0560392702629682 0.788938932942294 MirTarget -0.309553440629216 3.93996191126198e-07 NA NA NA hsa-miR-217 REL -1.35391381055929 2.42394951427902e-09 0.0560392702629682 0.788938932942294 miRanda -0.116200771449556 0.00325313687849405 NA NA NA hsa-miR-2355-5p REL 1.47205546931107 8.65192179636668e-19 0.0560392702629682 0.788938932942294 MirTarget -0.165809325033256 0.00171797745504265 NA NA NA hsa-miR-28-5p RELA -0.026996999089909 0.733047113251652 0.0427844130929831 0.511167069149631 miRanda -0.158597396386128 1.09687495536614e-05 NA NA NA hsa-miR-769-5p RELA 0.0865819375213306 0.445395188017017 0.0427844130929831 0.511167069149631 miRNATAP -0.115778992525935 3.19828405030521e-06 NA NA NA hsa-miR-103a-2-5p RGL1 1.37988337975616 6.74852943995612e-08 -0.242225685896881 0.0729895646519674 MirTarget -0.174682221240671 5.79427354386699e-13 NA NA NA hsa-miR-135b-5p RGL1 1.5570143078477 4.60753610971455e-13 -0.242225685896881 0.0729895646519674 MirTarget -0.123128617212618 3.44652572591915e-06 NA NA NA hsa-miR-16-2-3p RGL1 1.1567130855258 1.01867256952189e-14 -0.242225685896881 0.0729895646519674 mirMAP -0.201848030289449 1.10728078142187e-07 NA NA NA hsa-miR-17-5p RGL1 1.41924888736771 2.75805544953758e-18 -0.242225685896881 0.0729895646519674 MirTarget;TargetScan;miRNATAP -0.285200520815375 4.48407168986507e-17 NA NA NA hsa-miR-193a-3p RGL1 0.22120710726779 0.111827069464729 -0.242225685896881 0.0729895646519674 miRNATAP -0.266003757960106 1.93744175640919e-10 NA NA NA hsa-miR-19a-3p RGL1 1.35800152353624 2.80940447111944e-12 -0.242225685896881 0.0729895646519674 MirTarget;miRNATAP -0.246772149554354 8.31447683154747e-18 NA NA NA hsa-miR-19b-3p RGL1 0.538732279378089 0.000622008277870679 -0.242225685896881 0.0729895646519674 MirTarget;miRNATAP -0.2872362152517 2.64138477749314e-15 NA NA NA hsa-miR-200c-3p RGL1 0.630251054099546 0.000131975031451555 -0.242225685896881 0.0729895646519674 MirTarget;miRNATAP -0.100010777738094 0.00488649447086147 NA NA NA hsa-miR-20a-5p RGL1 1.1531986665452 1.02385132917958e-11 -0.242225685896881 0.0729895646519674 MirTarget;miRNATAP -0.26782764607912 6.19643921065436e-16 NA NA NA hsa-miR-22-5p RGL1 0.706731861922839 3.44318705980007e-07 -0.242225685896881 0.0729895646519674 mirMAP -0.256612409288674 6.312321163813e-10 NA NA NA hsa-miR-30c-5p RGL1 0.021222006155897 0.886366656528128 -0.242225685896881 0.0729895646519674 miRNATAP -0.135743079687649 0.000627722689628073 NA NA NA hsa-miR-339-5p RGL1 1.07771430326938 2.45772601859307e-09 -0.242225685896881 0.0729895646519674 miRNATAP -0.226453399630566 5.64034478397349e-13 NA NA NA hsa-miR-429 RGL1 0.559451508722375 0.00563641638673083 -0.242225685896881 0.0729895646519674 MirTarget;PITA;miRanda;miRNATAP -0.123945673694613 1.78986808165067e-05 NA NA NA hsa-miR-455-5p RGL1 1.408595672323 5.52039116456697e-22 -0.242225685896881 0.0729895646519674 miRanda -0.29000052573681 1.58641006679234e-14 NA NA NA hsa-miR-582-3p RGL1 -0.248056267546012 0.143798829508405 -0.242225685896881 0.0729895646519674 PITA -0.187295331477548 5.02293309399668e-08 NA NA NA hsa-miR-7-1-3p RGL1 1.13646121619622 1.49823237535933e-14 -0.242225685896881 0.0729895646519674 MirTarget;mirMAP -0.163673258292003 2.30379453628282e-05 NA NA NA hsa-miR-92a-3p RGL1 0.994679542307232 1.32587679156217e-16 -0.242225685896881 0.0729895646519674 MirTarget -0.288795234599639 8.09349590519172e-10 NA NA NA hsa-miR-93-5p RGL1 1.61042951896619 5.1280369606967e-24 -0.242225685896881 0.0729895646519674 MirTarget;miRNATAP -0.193730239682787 2.88641942871055e-08 NA NA NA hsa-miR-96-5p RGL1 1.42326703011157 4.39736150032373e-14 -0.242225685896881 0.0729895646519674 mirMAP -0.1120826120156 0.000220669999359495 NA NA NA hsa-miR-24-3p RGL2 0.13115428390042 0.203891651275156 -0.312671003380379 0.000189088711024009 miRNATAP -0.175462548153791 7.58767594155104e-07 NA NA NA hsa-miR-130b-5p RHOA 1.77265255049999 1.43627774829684e-29 -0.388216260165068 4.48279253908352e-10 MirTarget;miRNATAP -0.107033559733647 4.21158617305132e-11 NA NA NA hsa-miR-200b-3p RHOA 0.0717138787925347 0.682858087587209 -0.388216260165068 4.48279253908352e-10 MirTarget;TargetScan -0.104184324891353 1.21846120758679e-11 NA NA NA hsa-miR-200c-3p RHOA 0.630251054099546 0.000131975031451555 -0.388216260165068 4.48279253908352e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.100826191340189 6.50602293179483e-10 NA NA NA hsa-miR-361-5p RHOA 0.0803683277369505 0.314043140368058 -0.388216260165068 4.48279253908352e-10 MirTarget;PITA;miRanda -0.150868348890832 1.4439671126465e-05 NA NA NA hsa-miR-429 RHOA 0.559451508722375 0.00563641638673083 -0.388216260165068 4.48279253908352e-10 MirTarget;PITA;miRanda;miRNATAP -0.100812132665556 2.34045632505225e-14 NA NA NA hsa-miR-140-3p RRAS2 -0.967453553824782 7.6999446305445e-23 0.702932455850408 1.99932755914681e-08 MirTarget;PITA;miRNATAP -0.382023795806488 6.68154764495553e-13 NA NA NA hsa-miR-194-5p RRAS2 -0.0214221838459805 0.872940154118701 0.702932455850408 1.99932755914681e-08 MirTarget -0.188563549594164 4.77239889595257e-06 NA NA NA hsa-miR-23b-3p RRAS2 -0.497563803223134 3.31483353357535e-05 0.702932455850408 1.99932755914681e-08 MirTarget -0.320399440089145 1.24982516371635e-12 NA NA NA hsa-miR-26a-5p RRAS2 -1.09269574587169 1.24020612216319e-22 0.702932455850408 1.99932755914681e-08 MirTarget -0.355116291989998 2.49215931328835e-14 NA NA NA hsa-miR-29a-3p RRAS2 -1.26881270980079 2.82496991513463e-22 0.702932455850408 1.99932755914681e-08 miRNATAP -0.142232445447152 0.000456450629215303 NA NA NA hsa-miR-29c-3p RRAS2 -2.08166260448948 8.3238369390898e-24 0.702932455850408 1.99932755914681e-08 miRNATAP -0.226677031708636 2.97636306035379e-20 NA NA NA hsa-miR-30a-5p RRAS2 -1.79779915425811 1.93360169837799e-26 0.702932455850408 1.99932755914681e-08 miRNATAP -0.120338084173712 0.000103191367577221 NA NA NA hsa-miR-30d-5p RRAS2 -0.38399848121878 0.000171129616944749 0.702932455850408 1.99932755914681e-08 miRNATAP -0.268206087702559 6.34913882454062e-07 NA NA NA hsa-miR-200b-3p SHC1 0.0717138787925347 0.682858087587209 0.721046879245024 1.13910542478187e-11 miRNAWalker2_validate;TargetScan -0.173511318358696 5.69268679519869e-11 NA NA NA hsa-miR-30b-3p SHC1 -0.338530747940815 0.0223424741180399 0.721046879245024 1.13910542478187e-11 MirTarget;miRNATAP -0.216360251904268 5.08922409275823e-12 NA NA NA hsa-miR-30b-5p SHC1 -0.400238605368173 0.00346540992719245 0.721046879245024 1.13910542478187e-11 miRNAWalker2_validate -0.231209358231825 8.42400439986111e-12 NA NA NA hsa-miR-9-5p SHC1 1.65694862043766 2.08325802567323e-05 0.721046879245024 1.13910542478187e-11 MirTarget;miRNATAP -0.119239824521163 1.98823441336762e-25 NA NA NA hsa-miR-27b-5p SHC3 0.580870079022649 0.000181529223377382 -0.134533400117462 0.576383600365878 MirTarget -0.185540014444205 0.00587002848246122 NA NA NA hsa-miR-331-5p SHC3 0.851618030062133 1.42670149420057e-14 -0.134533400117462 0.576383600365878 PITA;miRNATAP -0.436896057581104 2.16211742269429e-06 NA NA NA hsa-miR-378a-5p SHC3 -1.31095692407946 2.375328908085e-15 -0.134533400117462 0.576383600365878 MirTarget -0.208786784881134 0.00069254888451455 NA NA NA hsa-miR-429 SHC3 0.559451508722375 0.00563641638673083 -0.134533400117462 0.576383600365878 miRNATAP -0.161035096691183 0.00184102877446985 NA NA NA hsa-miR-590-5p SHC3 0.763025362395968 3.65305892505623e-09 -0.134533400117462 0.576383600365878 miRanda -0.283899390773321 0.000386627108119689 NA NA NA hsa-miR-92a-3p SHC3 0.994679542307232 1.32587679156217e-16 -0.134533400117462 0.576383600365878 miRNAWalker2_validate -0.361673188647543 1.88749979906775e-05 NA NA NA hsa-miR-16-1-3p SHC4 0.955017760172879 5.95379292601146e-11 -0.599901658071386 0.0439375756733881 MirTarget -0.352441265363952 5.51847921896223e-05 NA NA NA hsa-miR-20a-3p SHC4 1.34885093664027 2.07697464119202e-12 -0.599901658071386 0.0439375756733881 miRNATAP -0.273704321154817 3.30237572781722e-05 NA NA NA hsa-miR-429 SHC4 0.559451508722375 0.00563641638673083 -0.599901658071386 0.0439375756733881 miRanda -0.195969922048417 0.00222150100359206 NA NA NA hsa-miR-576-5p SHC4 0.940432050128373 6.90227595663302e-12 -0.599901658071386 0.0439375756733881 mirMAP -0.36906921915126 6.90520448377632e-05 NA NA NA hsa-miR-590-5p SHC4 0.763025362395968 3.65305892505623e-09 -0.599901658071386 0.0439375756733881 miRanda -0.390853149008005 7.83545817993589e-05 NA NA NA hsa-miR-96-5p SHC4 1.42326703011157 4.39736150032373e-14 -0.599901658071386 0.0439375756733881 TargetScan;miRNATAP -0.218123758152066 0.00114748886091498 NA NA NA hsa-miR-103a-3p SHOC2 0.556219385347418 1.55815736455067e-09 -0.328991789674881 8.34135649825646e-07 miRNAWalker2_validate -0.182327060144425 5.094101087512e-09 NA NA NA hsa-miR-106b-5p SHOC2 0.50378717276868 1.45412404526866e-05 -0.328991789674881 8.34135649825646e-07 MirTarget;miRNATAP -0.116050756013359 3.30457688835856e-06 NA NA NA hsa-miR-15a-5p SHOC2 0.783550182002274 2.60699595655907e-11 -0.328991789674881 8.34135649825646e-07 MirTarget;miRNATAP -0.178992395168218 8.28410920901458e-14 NA NA NA hsa-miR-15b-5p SHOC2 0.85315666454713 3.79816274836297e-12 -0.328991789674881 8.34135649825646e-07 MirTarget;miRNATAP -0.137914517647628 2.34625607247289e-09 NA NA NA hsa-miR-17-5p SHOC2 1.41924888736771 2.75805544953758e-18 -0.328991789674881 8.34135649825646e-07 MirTarget;TargetScan;miRNATAP -0.119342080489725 2.48648001484311e-12 NA NA NA hsa-miR-182-5p SHOC2 1.15060905311096 6.25565852529946e-10 -0.328991789674881 8.34135649825646e-07 MirTarget -0.108754857603486 6.6805158542756e-13 NA NA NA hsa-miR-186-5p SHOC2 0.353452958261612 0.000145058448579496 -0.328991789674881 8.34135649825646e-07 miRNATAP -0.115892418275751 0.000236459835850332 NA NA NA hsa-miR-20a-5p SHOC2 1.1531986665452 1.02385132917958e-11 -0.328991789674881 8.34135649825646e-07 MirTarget;miRNATAP -0.125876226881306 2.46971132919039e-14 NA NA NA hsa-miR-26b-5p SHOC2 -0.254478038884324 0.0285227763044636 -0.328991789674881 8.34135649825646e-07 miRNAWalker2_validate -0.109538609359393 1.33131297565964e-05 NA NA NA hsa-miR-30b-5p SHOC2 -0.400238605368173 0.00346540992719245 -0.328991789674881 8.34135649825646e-07 MirTarget -0.136309240991239 8.86865759651905e-11 NA NA NA hsa-miR-30c-5p SHOC2 0.021222006155897 0.886366656528128 -0.328991789674881 8.34135649825646e-07 MirTarget;miRNATAP -0.134192292491433 4.43458061313967e-12 NA NA NA hsa-miR-34a-5p SHOC2 -0.117372471043915 0.364001947180738 -0.328991789674881 8.34135649825646e-07 miRNATAP -0.135019651616337 1.72255510926018e-09 NA NA NA hsa-miR-361-5p SHOC2 0.0803683277369505 0.314043140368058 -0.328991789674881 8.34135649825646e-07 PITA;miRanda -0.123822012827399 0.000879681157761795 NA NA NA hsa-miR-374b-3p SHOC2 0.425603499218802 0.00146686864653282 -0.328991789674881 8.34135649825646e-07 MirTarget -0.108839691271278 5.7288668163424e-07 NA NA NA hsa-miR-374b-5p SHOC2 -0.288413933608091 0.0041474558664058 -0.328991789674881 8.34135649825646e-07 MirTarget;mirMAP;miRNATAP -0.166886592166736 7.69699871351883e-09 NA NA NA hsa-miR-500a-5p SHOC2 0.675401699376111 8.24389004707854e-05 -0.328991789674881 8.34135649825646e-07 MirTarget -0.107931991444109 9.78142719920271e-11 NA NA NA hsa-miR-92a-3p SHOC2 0.994679542307232 1.32587679156217e-16 -0.328991789674881 8.34135649825646e-07 miRNAWalker2_validate -0.163061400708379 2.21216827736925e-12 NA NA NA hsa-miR-93-5p SHOC2 1.61042951896619 5.1280369606967e-24 -0.328991789674881 8.34135649825646e-07 MirTarget;miRNATAP -0.144321579134475 2.1894135369127e-17 NA NA NA hsa-miR-103a-2-5p SOS1 1.37988337975616 6.74852943995612e-08 -0.14430779210223 0.0788675470799712 MirTarget -0.107317494895258 2.70560419461077e-13 NA NA NA hsa-miR-17-5p SOS1 1.41924888736771 2.75805544953758e-18 -0.14430779210223 0.0788675470799712 MirTarget;TargetScan;miRNATAP -0.117731171602632 1.95189099419506e-08 NA NA NA hsa-miR-181a-5p SOS1 0.819060835827404 1.38616688310277e-13 -0.14430779210223 0.0788675470799712 MirTarget;miRNATAP -0.100672350932981 0.00144883651704136 NA NA NA hsa-miR-181b-5p SOS1 0.974255518824355 2.64876280203475e-16 -0.14430779210223 0.0788675470799712 MirTarget;miRNATAP -0.148558703111288 2.95988138178714e-07 NA NA NA hsa-miR-186-5p SOS1 0.353452958261612 0.000145058448579496 -0.14430779210223 0.0788675470799712 MirTarget;mirMAP -0.152552364062524 7.16812353278593e-05 NA NA NA hsa-miR-20a-5p SOS1 1.1531986665452 1.02385132917958e-11 -0.14430779210223 0.0788675470799712 MirTarget;miRNATAP -0.12022910939126 3.57951889599424e-09 NA NA NA hsa-miR-22-5p SOS1 0.706731861922839 3.44318705980007e-07 -0.14430779210223 0.0788675470799712 miRNATAP -0.158730685582191 2.71506892378126e-10 NA NA NA hsa-miR-30b-5p SOS1 -0.400238605368173 0.00346540992719245 -0.14430779210223 0.0788675470799712 mirMAP -0.126352161603185 1.03698542764349e-06 NA NA NA hsa-miR-30c-5p SOS1 0.021222006155897 0.886366656528128 -0.14430779210223 0.0788675470799712 mirMAP;miRNATAP -0.135903886215057 1.16781024741833e-08 NA NA NA hsa-miR-339-5p SOS1 1.07771430326938 2.45772601859307e-09 -0.14430779210223 0.0788675470799712 miRNATAP -0.128892301297403 1.48838832376727e-11 NA NA NA hsa-miR-365a-3p SOS1 0.446833934952926 0.00233857759218299 -0.14430779210223 0.0788675470799712 miRNATAP -0.1783566963117 5.57885493367077e-14 NA NA NA hsa-miR-576-5p SOS1 0.940432050128373 6.90227595663302e-12 -0.14430779210223 0.0788675470799712 mirMAP -0.137121069751198 5.95871216796928e-08 NA NA NA hsa-miR-590-5p SOS1 0.763025362395968 3.65305892505623e-09 -0.14430779210223 0.0788675470799712 miRanda -0.102087263279598 0.000173697009124336 NA NA NA hsa-miR-130a-3p SOS2 0.67051191119964 4.89747518735144e-06 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.142452400506012 9.1977279101434e-07 NA NA NA hsa-miR-130b-3p SOS2 1.44628430084411 9.13980959861273e-24 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.166141799618233 4.74896683998837e-09 NA NA NA hsa-miR-140-5p SOS2 -0.412389003031485 0.000136051708543369 -0.413855174319239 2.70724213132607e-05 miRanda -0.115984900471818 0.00375469960502604 NA NA NA hsa-miR-146b-5p SOS2 0.917975986853978 3.33749259316025e-09 -0.413855174319239 2.70724213132607e-05 miRanda -0.148988622111336 4.132997452968e-08 NA NA NA hsa-miR-15a-5p SOS2 0.783550182002274 2.60699595655907e-11 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.246192745452679 4.355188886614e-12 NA NA NA hsa-miR-15b-5p SOS2 0.85315666454713 3.79816274836297e-12 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.183474265512814 8.3295370014568e-08 NA NA NA hsa-miR-16-5p SOS2 0.521122945828175 1.40561786410572e-06 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.154096465704255 0.000106046501996405 NA NA NA hsa-miR-21-5p SOS2 1.62465922021121 3.44191300985109e-58 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.19831212276022 1.74180372845288e-07 NA NA NA hsa-miR-301a-3p SOS2 2.14132004241926 4.46255413526808e-25 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.120432560927103 7.67307961625067e-10 NA NA NA hsa-miR-320a SOS2 0.801356001806321 4.91397101474502e-09 -0.413855174319239 2.70724213132607e-05 miRanda;miRNATAP -0.180058190704833 4.89057631979479e-09 NA NA NA hsa-miR-454-3p SOS2 1.54137391927201 4.15861570449376e-20 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.189860305441434 3.92270128753751e-15 NA NA NA hsa-miR-590-3p SOS2 0.221436901462551 0.0965904764063157 -0.413855174319239 2.70724213132607e-05 miRanda;mirMAP -0.11728383435213 0.000301105591653965 NA NA NA hsa-miR-590-5p SOS2 0.763025362395968 3.65305892505623e-09 -0.413855174319239 2.70724213132607e-05 PITA;miRanda;miRNATAP -0.141487335002342 1.65802166639907e-05 NA NA NA hsa-miR-199a-5p STK4 -0.364835768178638 0.0435119211101981 0.441383320872455 5.94781219218678e-07 MirTarget;PITA;miRanda;miRNATAP -0.134283532499914 2.16534408842331e-10 NA NA NA hsa-miR-199b-5p STK4 -1.08432682485992 7.68241801134089e-10 0.441383320872455 5.94781219218678e-07 MirTarget;PITA;miRanda;miRNATAP -0.148320825198252 3.01853905391201e-12 NA NA NA hsa-miR-30b-5p STK4 -0.400238605368173 0.00346540992719245 0.441383320872455 5.94781219218678e-07 mirMAP -0.147015913339128 1.69495044513221e-07 NA NA NA hsa-miR-30c-5p STK4 0.021222006155897 0.886366656528128 0.441383320872455 5.94781219218678e-07 mirMAP -0.107938471931551 3.59973259421155e-05 NA NA NA hsa-miR-30d-3p STK4 -0.577371911152798 2.02950840095287e-06 0.441383320872455 5.94781219218678e-07 mirMAP -0.133485121293029 2.58011987837031e-05 NA NA NA hsa-miR-362-5p STK4 0.41089772861323 0.0404254902071382 0.441383320872455 5.94781219218678e-07 mirMAP -0.127568048731838 1.91938636613902e-11 NA NA NA hsa-miR-374b-5p STK4 -0.288413933608091 0.0041474558664058 0.441383320872455 5.94781219218678e-07 mirMAP -0.128830141142017 0.000896012868443367 NA NA NA hsa-miR-495-3p STK4 -1.47803501311999 6.88839745293927e-13 0.441383320872455 5.94781219218678e-07 MirTarget -0.101290154759527 3.01186949363466e-08 NA NA NA hsa-miR-664a-3p STK4 -0.256108763664991 0.0513188660751664 0.441383320872455 5.94781219218678e-07 mirMAP -0.141373810864845 1.55872148833693e-06 NA NA NA hsa-miR-455-5p TEK 1.408595672323 5.52039116456697e-22 -0.811440710527928 5.69194413665357e-05 miRanda -0.425414566026056 7.03195605940042e-14 NA NA NA hsa-miR-127-3p TGFA -1.47175957435172 9.8707469067377e-14 0.471727986880251 0.0113818927785784 miRanda -0.141382459165978 0.000414490089130158 NA NA NA hsa-miR-140-3p TGFA -0.967453553824782 7.6999446305445e-23 0.471727986880251 0.0113818927785784 miRNATAP -0.467811848334099 2.99965838244465e-09 NA NA NA hsa-miR-148a-3p TGFA -0.428944290834563 0.00954246923521465 0.471727986880251 0.0113818927785784 miRNATAP -0.295663414803172 1.05042629234724e-09 NA NA NA hsa-miR-181c-5p TGFA -0.168991199007857 0.196949106150297 0.471727986880251 0.0113818927785784 mirMAP -0.448953172504114 1.94673209653859e-13 NA NA NA hsa-miR-199a-5p TGFA -0.364835768178638 0.0435119211101981 0.471727986880251 0.0113818927785784 miRNATAP -0.227002907986154 3.66131696673185e-07 NA NA NA hsa-miR-199b-5p TGFA -1.08432682485992 7.68241801134089e-10 0.471727986880251 0.0113818927785784 miRNATAP -0.135537208331098 0.00283719224643909 NA NA NA hsa-miR-23b-3p TGFA -0.497563803223134 3.31483353357535e-05 0.471727986880251 0.0113818927785784 miRNATAP -0.223744977100315 0.000947483091760639 NA NA NA hsa-miR-28-5p TGFA -0.026996999089909 0.733047113251652 0.471727986880251 0.0113818927785784 miRanda -0.716739492778532 3.02236769253326e-12 NA NA NA hsa-miR-29b-2-5p TGFA -0.502720326849742 0.000730448246894952 0.471727986880251 0.0113818927785784 mirMAP -0.26552490768259 9.45493554660137e-07 NA NA NA hsa-miR-335-3p TGFA 0.336785882180547 0.0542446207938138 0.471727986880251 0.0113818927785784 mirMAP -0.151211914058655 0.00113553869536674 NA NA NA hsa-miR-342-3p TGFA 0.99756868977753 9.28499866272332e-10 0.471727986880251 0.0113818927785784 miRanda -0.155245570093664 0.00157925124207155 NA NA NA hsa-miR-491-5p TGFA -0.541680329196715 0.00135829217561865 0.471727986880251 0.0113818927785784 miRanda -0.270228376430328 5.5689748399773e-08 NA NA NA hsa-miR-495-3p TGFA -1.47803501311999 6.88839745293927e-13 0.471727986880251 0.0113818927785784 mirMAP -0.148801898062084 0.000116065245602931 NA NA NA hsa-miR-127-3p TIAM1 -1.47175957435172 9.8707469067377e-14 -0.562638794928056 0.000451990074118884 miRanda -0.128512756738068 0.000197230037761293 NA NA NA hsa-miR-1306-3p TIAM1 0.980574937077146 8.9638516259317e-09 -0.562638794928056 0.000451990074118884 MirTarget -0.122704060430983 0.00313177674963395 NA NA NA hsa-miR-146b-5p TIAM1 0.917975986853978 3.33749259316025e-09 -0.562638794928056 0.000451990074118884 miRanda -0.187073215307087 2.52894044849487e-05 NA NA NA hsa-miR-21-5p TIAM1 1.62465922021121 3.44191300985109e-58 -0.562638794928056 0.000451990074118884 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.280181490552896 5.98989985203014e-06 20826792 miR 21 and miR 31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells; We present compelling evidence that TIAM1 a guanidine exchange factor of the Rac GTPase is a direct target of both miR-21 and miR-31 colon cancer hsa-miR-22-3p TIAM1 0.00776313533473072 0.926356548861307 -0.562638794928056 0.000451990074118884 MirTarget -0.292760610600425 0.00055542890843699 23440286 Computational in silico analysis predicted that T-cell lymphoma invasion and metastasis 1 TIAM1 is a target gene of miR-22; This was confirmed by qRT-PCR and western blotting which showed that miR-22 expression inhibited TIAM1 mRNA and protein expression respectively; Collectively these data suggest that miR-22 may act as a tumor suppressor in colon cancer most likely by targeting TIAM1 expression metastasis lymphoma hsa-miR-29a-5p TIAM1 0.323252792625584 0.0370417231222825 -0.562638794928056 0.000451990074118884 MirTarget -0.173375931580187 0.000124726338936051 NA NA NA hsa-miR-320a TIAM1 0.801356001806321 4.91397101474502e-09 -0.562638794928056 0.000451990074118884 miRanda;miRNATAP -0.132499751634733 0.00893831765130761 NA NA NA hsa-miR-335-3p TIAM1 0.336785882180547 0.0542446207938138 -0.562638794928056 0.000451990074118884 MirTarget -0.136202719303628 0.000674639084915888 NA NA NA hsa-miR-376c-3p TIAM1 -1.70422793441579 1.16555506116207e-15 -0.562638794928056 0.000451990074118884 MirTarget -0.171015719733097 7.09360019635572e-08 NA NA NA hsa-miR-758-3p TIAM1 -0.570329021195882 0.00789852529051916 -0.562638794928056 0.000451990074118884 MirTarget -0.164010296774701 4.03225800904147e-07 NA NA NA hsa-miR-101-3p VEGFA -1.91263766544878 1.50270129259053e-39 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate -0.281477062331858 8.81075776241686e-11 NA NA NA hsa-miR-134-5p VEGFA -0.598302069876985 0.00124773585997939 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.114375387301794 0.00210306889630562 NA NA NA hsa-miR-140-5p VEGFA -0.412389003031485 0.000136051708543369 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.268410061738275 2.63838447575462e-05 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-150-5p VEGFA -0.243749814009231 0.331546276920338 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase -0.1837154779422 1.13782348414927e-11 NA NA NA hsa-miR-195-5p VEGFA -1.8367376818177 6.9944883988895e-31 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.266371206927854 4.016968187035e-11 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199b-5p VEGFA -1.08432682485992 7.68241801134089e-10 0.873514320132464 2.52351953389146e-08 miRanda -0.107087744674295 0.00559641745284255 NA NA NA hsa-miR-29a-3p VEGFA -1.26881270980079 2.82496991513463e-22 0.873514320132464 2.52351953389146e-08 MirTarget -0.288406509783812 9.95429090012523e-09 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29c-3p VEGFA -2.08166260448948 8.3238369390898e-24 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;MirTarget -0.194088476141854 6.98364039221839e-10 NA NA NA hsa-miR-374a-5p VEGFA -0.621903385111545 6.61791773205282e-12 0.873514320132464 2.52351953389146e-08 MirTarget -0.350545644085801 3.16629895028707e-06 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-378a-3p VEGFA -1.50453783521372 9.41694954361173e-17 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase -0.103722847977571 0.00515698881281656 NA NA NA hsa-miR-128-3p VEGFC -0.170677254601174 0.20412808476528 1.21496433527706 2.56999707057218e-05 miRNAWalker2_validate;MirTarget -0.344606861179054 0.000264644189549296 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-129-5p VEGFC -0.246329588499478 0.436451191224681 1.21496433527706 2.56999707057218e-05 miRanda -0.181674391970532 6.89957949062694e-06 NA NA NA hsa-miR-16-2-3p VEGFC 1.1567130855258 1.01867256952189e-14 1.21496433527706 2.56999707057218e-05 MirTarget -0.264631968748485 0.00136032612419468 NA NA NA hsa-miR-27b-3p VEGFC -0.732682718863563 2.26896143573324e-09 1.21496433527706 2.56999707057218e-05 MirTarget -1.03529262957351 2.14560495828989e-26 23593282 We identified vascular endothelial growth factor C VEGFC as a novel target gene of miR-27b and determined that miR-27b functioned as an inhibitor of tumor progression and angiogenesis through targeting VEGFC in CRC; In summary an anti-tumor role for miR-27b and its novel target VEGFC in vivo could lead to tumor necrosis and provide a rationale for developing miR-27b as a therapeutic agent progression colorectal cancer hsa-miR-374a-5p VEGFC -0.621903385111545 6.61791773205282e-12 1.21496433527706 2.56999707057218e-05 MirTarget -0.421266396238901 0.00236790056229042 NA NA NA hsa-miR-185-3p ZAP70 0.653637407906201 6.54212996668668e-05 0.49893863092126 0.0512340315066753 MirTarget -0.228272619696595 0.000760988626927723 NA NA NA