miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-125b-5p AIFM1 0.042694645848468 0.980586836124662 -0.125311783713426 0.933160268642419 miRNATAP -0.0652515071688461 0.0457119530009747 NA NA NA hsa-miR-125b-5p AKT1 0.042694645848468 0.980586836124662 -0.056136082271725 0.974015558458135 miRNAWalker2_validate;miRTarBase -0.0564146274999625 0.00667922382968911 NA NA NA hsa-miR-106a-5p AKT3 -0.203919267842652 0.802213958426804 0.457269233600447 0.539326812115034 miRNATAP -0.549479065869633 4.88994896864722e-11 NA NA NA hsa-miR-106b-5p AKT3 -0.297128724729339 0.869294443540749 0.457269233600447 0.539326812115034 miRNATAP -0.910251258276316 1.51432008761514e-23 NA NA NA hsa-miR-107 AKT3 -0.0365118169251648 0.988364120226869 0.457269233600447 0.539326812115034 PITA;miRanda -0.551086378595188 0.000172037624489873 NA NA NA hsa-miR-1275 AKT3 -0.831342050607648 0.0803795852164229 0.457269233600447 0.539326812115034 PITA -0.265795172887599 9.47325565176386e-07 NA NA NA hsa-miR-140-5p AKT3 -0.229213026275906 0.847330111738616 0.457269233600447 0.539326812115034 miRanda -0.293235686594899 0.0229652780617548 NA NA NA hsa-miR-142-3p AKT3 -0.154235241441331 0.946098054588918 0.457269233600447 0.539326812115034 miRanda -0.196043223886578 0.00627089530211866 NA NA NA hsa-miR-15a-5p AKT3 -0.0674049094129128 0.964835434214123 0.457269233600447 0.539326812115034 miRNAWalker2_validate;miRTarBase;miRNATAP -0.721206491484116 7.61586942839311e-13 NA NA NA hsa-miR-15b-5p AKT3 -0.272614787130877 0.87096541832188 0.457269233600447 0.539326812115034 miRNATAP -0.665977383717092 1.97063059627596e-12 NA NA NA hsa-miR-16-5p AKT3 0.0135949734723564 0.994476223855607 0.457269233600447 0.539326812115034 miRNAWalker2_validate;miRTarBase;miRNATAP -0.746124766270904 9.10401236853758e-16 NA NA NA hsa-miR-17-3p AKT3 0.100221625453134 0.960113387014848 0.457269233600447 0.539326812115034 miRNATAP -0.519758313376015 2.03997342351785e-09 NA NA NA hsa-miR-17-5p AKT3 -0.175448849583061 0.934544015912731 0.457269233600447 0.539326812115034 TargetScan;miRNATAP -0.626536048377156 1.11076874125702e-18 NA NA NA hsa-miR-181b-5p AKT3 0.155313039554487 0.930176779696506 0.457269233600447 0.539326812115034 miRNATAP -0.268064668813324 0.00963449049657038 NA NA NA hsa-miR-20a-5p AKT3 -0.179153323927949 0.928118119139752 0.457269233600447 0.539326812115034 miRNATAP -0.531063551395964 1.32783278364081e-13 NA NA NA hsa-miR-28-3p AKT3 -0.227916837431808 0.935350995840384 0.457269233600447 0.539326812115034 miRNATAP -0.521845591393563 0.00718630427898147 NA NA NA hsa-miR-29a-3p AKT3 0.01127474410284 0.996977020481272 0.457269233600447 0.539326812115034 miRNATAP -0.812359982380835 1.03842433672581e-13 NA NA NA hsa-miR-29b-3p AKT3 -0.104016192263954 0.958988036765397 0.457269233600447 0.539326812115034 miRNATAP -0.677276652111253 9.58518141369729e-17 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-32-3p AKT3 -0.568003960723004 0.13133163420273 0.457269233600447 0.539326812115034 mirMAP -0.563455040593992 1.29815959529041e-22 NA NA NA hsa-miR-320a AKT3 -0.416546433767628 0.840202138616422 0.457269233600447 0.539326812115034 PITA;miRanda;miRNATAP -0.333446337886203 0.00137735387479576 NA NA NA hsa-miR-320b AKT3 -0.23561798088153 0.859222532827992 0.457269233600447 0.539326812115034 PITA;miRanda;miRNATAP -0.247020375326149 0.00854841822062789 NA NA NA hsa-miR-320c AKT3 -0.577462251570141 0.113597318870228 0.457269233600447 0.539326812115034 PITA;miRanda;miRNATAP -0.168706913972951 0.0152504739210101 NA NA NA hsa-miR-335-3p AKT3 -0.244830745789445 0.88450019116631 0.457269233600447 0.539326812115034 mirMAP -0.579661626156677 1.71660731221086e-14 NA NA NA hsa-miR-33a-3p AKT3 -0.794543849238581 0.0105203072007922 0.457269233600447 0.539326812115034 mirMAP -0.48908545949649 5.69174183767199e-12 NA NA NA hsa-miR-340-5p AKT3 -0.00276909425328853 0.99757361161055 0.457269233600447 0.539326812115034 mirMAP -0.282303409119482 0.00600476945925659 NA NA NA hsa-miR-362-3p AKT3 -0.721040238345347 0.0345881362485733 0.457269233600447 0.539326812115034 miRanda -0.415414242264488 1.82625494243827e-09 NA NA NA hsa-miR-362-5p AKT3 -0.26647467080141 0.752024885130738 0.457269233600447 0.539326812115034 PITA;TargetScan;miRNATAP -0.516617267683569 4.2053666241316e-16 NA NA NA hsa-miR-369-3p AKT3 0.116576891957687 0.83230082995912 0.457269233600447 0.539326812115034 mirMAP -0.2347933374382 0.00901179401751285 NA NA NA hsa-miR-374a-5p AKT3 -0.343007247142618 0.766921280269271 0.457269233600447 0.539326812115034 mirMAP -0.579942468779622 2.643062323348e-06 NA NA NA hsa-miR-374b-5p AKT3 -0.285682091626878 0.83569830479965 0.457269233600447 0.539326812115034 mirMAP -0.684416910019692 6.98155817205318e-09 NA NA NA hsa-miR-421 AKT3 -0.182032017078616 0.734704500318599 0.457269233600447 0.539326812115034 miRanda;mirMAP -0.463766741666901 1.36843495165118e-08 NA NA NA hsa-miR-424-5p AKT3 0.247080963500746 0.870154571783568 0.457269233600447 0.539326812115034 miRNATAP -0.239499066096292 0.00104453067376223 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth liver cancer hsa-miR-501-3p AKT3 -0.753812576327832 0.552763280802254 0.457269233600447 0.539326812115034 miRNATAP -0.497935902986368 2.06014814106823e-10 NA NA NA hsa-miR-502-3p AKT3 -0.481234445251923 0.514301076452422 0.457269233600447 0.539326812115034 miRNATAP -0.644160673294049 1.58962279838432e-12 NA NA NA hsa-miR-502-5p AKT3 -0.708507838520586 0.0261309781860104 0.457269233600447 0.539326812115034 PITA;miRNATAP -0.409328372897747 4.31887851181114e-09 NA NA NA hsa-miR-505-3p AKT3 -0.469094267152605 0.690382680489578 0.457269233600447 0.539326812115034 mirMAP -0.774927841273818 6.77311058531751e-15 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-539-5p AKT3 0.124342970087029 0.801067485473643 0.457269233600447 0.539326812115034 mirMAP;miRNATAP -0.192395187722177 0.046702748153238 NA NA NA hsa-miR-548o-3p AKT3 -0.191447572716994 0.517725546183501 0.457269233600447 0.539326812115034 mirMAP -0.314174287829114 7.58105126731538e-05 NA NA NA hsa-miR-577 AKT3 -1.06238199218774 0.326056761787754 0.457269233600447 0.539326812115034 mirMAP -0.383091519653111 6.42065724452006e-20 NA NA NA hsa-miR-663b AKT3 0.101100389887233 0.814989939749933 0.457269233600447 0.539326812115034 PITA -0.247711064601903 1.07528758067609e-05 NA NA NA hsa-miR-769-5p AKT3 -0.306614906942583 0.735704301598833 0.457269233600447 0.539326812115034 PITA;miRNATAP -0.8409977584726 1.11686042031466e-14 NA NA NA hsa-miR-93-5p AKT3 -0.611073677204699 0.825297877093193 0.457269233600447 0.539326812115034 miRNATAP -0.762020096686085 6.75211862260925e-18 NA NA NA hsa-miR-708-3p APAF1 0.137785606206693 0.896980471394499 -0.173549826698829 0.88665142839701 mirMAP -0.105643259572274 0.00109765096412761 NA NA NA hsa-miR-146b-5p ATM -0.402662509440887 0.837510937985091 0.191778405096067 0.864625288192543 miRanda -0.0862850781319478 0.0396767786863694 27602131 The role of microRNA 146b miR-146b in ATC remains to be elucidated; In order to characterize the role of miR-146b in ATC overexpression or interference of miR-146b was induced in ATC cell lines and cell proliferation and migration were evaluated; The potential targets of miR-146b were searched in the Gene Expression Omnibus database for ATC and matched non-tumor control samples; The expression level of potential targets was detected following overexpression or interference of miR-146b in ATC cell lines; In addition cell migration of ATC was also affected by miR-146b; During the search for potential targets of miR-146b in ATC p21 also known as p21Waf1/Cip1 or CDKN1A was noted for its role in cell cycle progression and tumor pathogenesis; In conclusion p21 may participate in the regulation of ATC cell proliferation by miR-146b cell migration;progression thyroid cancer hsa-miR-18a-5p ATM -0.498318455303917 0.61264091975585 0.191778405096067 0.864625288192543 miRNAWalker2_validate;miRTarBase;MirTarget -0.0699989479158247 0.00927401895186021 23229340;23437304;25963391;23857602 MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases;MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer progression;;; colon cancer;colorectal cancer;cervical and endocervical cancer;breast cancer hsa-miR-21-5p ATM -0.148920887107433 0.970240620972126 0.191778405096067 0.864625288192543 mirMAP -0.12276186501092 0.0491599985635331 26289851 MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy thyroid cancer hsa-miR-26b-5p ATM -0.0245931278499594 0.990377966314923 0.191778405096067 0.864625288192543 MirTarget -0.103130307633324 0.0363870737164835 NA NA NA hsa-miR-29a-5p ATM -0.31835175571979 0.600442757817281 0.191778405096067 0.864625288192543 mirMAP -0.082623643594722 0.0139115273831225 NA NA NA hsa-miR-324-5p ATM -0.50063248413014 0.537416710557032 0.191778405096067 0.864625288192543 miRanda -0.12216548800381 0.00154765973160933 NA NA NA hsa-miR-339-5p ATM -0.300425087100667 0.712912847076788 0.191778405096067 0.864625288192543 miRanda -0.0689434193517148 0.0223163324260992 NA NA NA hsa-miR-362-3p ATM -0.721040238345347 0.0345881362485733 0.191778405096067 0.864625288192543 miRanda -0.0690500577591391 0.0211326867524352 NA NA NA hsa-miR-455-5p ATM -0.139599153671262 0.865744220236311 0.191778405096067 0.864625288192543 miRanda -0.119520466419818 0.00128133661552861 NA NA NA hsa-miR-576-5p ATM -0.506413219377403 0.417187951364173 0.191778405096067 0.864625288192543 mirMAP -0.0879176255300629 0.0170921289053618 NA NA NA hsa-miR-577 ATM -1.06238199218774 0.326056761787754 0.191778405096067 0.864625288192543 PITA -0.0594594152440409 0.00179326659385019 NA NA NA hsa-miR-590-3p ATM -0.279244755376859 0.59126669933662 0.191778405096067 0.864625288192543 miRanda;mirMAP -0.0644419567693109 0.0361829187580142 NA NA NA hsa-miR-590-5p ATM -0.547819833829572 0.472735645776647 0.191778405096067 0.864625288192543 mirMAP -0.103121093611562 0.00141721793607095 NA NA NA hsa-miR-129-5p BAD 0.268577986151378 0.553351908525147 0.099462334703678 0.932663252277438 miRanda -0.068966789667319 0.00167682319935558 NA NA NA hsa-miR-153-3p BCL2 -0.503770982320954 0.306832928666904 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.115035273015965 0.0323038102658718 19676043;21213215 Bioinformatics analysis revealed that anti-apoptosis family member B-cell lymphoma 2 Bcl-2 and myeloid cell leukemia sequence 1 Mcl-1 are potential targets of miR-153; Indeed Western blot analysis indicated that miR-153 downregulated both Bcl-2 and Mcl-1 at the protein levels; By luciferase reporter assays we further showed that miR-153 inhibited Bcl-2 and Mcl-1 expressions by directly targeting the 3'UTR regions of their respective mRNAs;Previously we established that microRNA-153 miR-153 induces apoptosis by downregulating B-cell lymphoma 2 Bcl-2 and myeloid cell leukemia sequence 1 Mcl-1 protein expression levels in glioblastoma cell line DBTRG-05MG ; B cell lymphoma;glioblastoma hsa-miR-15a-5p BCL2 -0.0674049094129128 0.964835434214123 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.221269651862381 0.0291079667853282 25623762;25594541;26915294;18931683;22335947 miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 drug resistance;;poor survival;; colon cancer;breast cancer;lung cancer;prostate cancer;breast cancer hsa-miR-16-5p BCL2 0.0135949734723564 0.994476223855607 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.229379064751398 0.0155316850668972 25623762;21336967;24447552;18449891;25435430;24598659;18931683;22966344 miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene drug resistance;;worse prognosis;drug resistance;;;;poor survival colon cancer;liver cancer;lymphoma;gastric cancer;lung cancer;lymphoma;prostate cancer;pancreatic cancer hsa-miR-17-5p BCL2 -0.175448849583061 0.934544015912731 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.313088312531828 1.57403483137732e-05 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-192-5p BCL2 -0.117345487848223 0.972927287653137 -0.871666186967121 0.244961397784127 miRNAWalker2_validate -0.227903685596688 0.000564938952369163 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-196b-5p BCL2 -0.0840912027031901 0.972112413910242 -0.871666186967121 0.244961397784127 miRNAWalker2_validate -0.126443433292796 0.00925777817775241 NA NA NA hsa-miR-20a-3p BCL2 0.456808229166028 0.57674056136504 -0.871666186967121 0.244961397784127 mirMAP -0.189828863199929 0.00114914427656055 NA NA NA hsa-miR-20a-5p BCL2 -0.179153323927949 0.928118119139752 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.252117244065233 0.000458303345864534 NA NA NA hsa-miR-224-3p BCL2 0.110372723153393 0.749091467231007 -0.871666186967121 0.244961397784127 mirMAP -0.178399757407561 0.00774691671641716 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-224-5p BCL2 -0.240425158977724 0.857351098476517 -0.871666186967121 0.244961397784127 mirMAP -0.301573774179688 5.62748011416914e-07 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 -0.0947200031589666 0.920155111594601 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.410993226860356 0.00011884046804375 NA NA NA hsa-miR-29a-3p BCL2 0.01127474410284 0.996977020481272 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.340900217647213 0.00193580882132839 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29a-5p BCL2 -0.31835175571979 0.600442757817281 -0.871666186967121 0.244961397784127 mirMAP -0.343932614708693 5.20598038228022e-06 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29b-3p BCL2 -0.104016192263954 0.958988036765397 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.269579801072406 0.00119448246860227 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-335-3p BCL2 -0.244830745789445 0.88450019116631 -0.871666186967121 0.244961397784127 mirMAP -0.24751331586752 0.0011768675011956 NA NA NA hsa-miR-33a-5p BCL2 -0.205788753603336 0.853314500865147 -0.871666186967121 0.244961397784127 mirMAP -0.128574385145016 0.00455510277772182 NA NA NA hsa-miR-374b-5p BCL2 -0.285682091626878 0.83569830479965 -0.871666186967121 0.244961397784127 mirMAP -0.287415339961428 0.0137036550670719 NA NA NA hsa-miR-450b-5p BCL2 -0.0136687538973108 0.983149761399849 -0.871666186967121 0.244961397784127 mirMAP -0.240978719259764 0.00585784315473669 NA NA NA hsa-miR-452-5p BCL2 -0.0504626418153507 0.973874641360401 -0.871666186967121 0.244961397784127 mirMAP -0.275409981212347 0.000609740122960845 NA NA NA hsa-miR-590-5p BCL2 -0.547819833829572 0.472735645776647 -0.871666186967121 0.244961397784127 miRanda -0.179521481010005 0.015541719980996 NA NA NA hsa-miR-7-5p BCL2 0.209645143210379 0.773705612298441 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase;mirMAP -0.195234863896821 0.000177663908838853 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-let-7a-5p BCL2L1 -0.0620211756550422 0.985006886285188 0.242557541702429 0.890959530804569 TargetScan;miRNATAP -0.267237022843277 0.00149660612153832 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-miR-326 BCL2L1 -0.567362118421427 0.620696901956282 0.242557541702429 0.890959530804569 PITA;miRanda;mirMAP;miRNATAP -0.099041496655029 0.0399192231035971 NA NA NA hsa-miR-511-5p BID -0.308591187445274 0.607200373476563 -0.0564874194903311 0.96522584673015 MirTarget -0.0855618188005745 0.00371239195472182 NA NA NA hsa-miR-126-5p BIRC2 0.0815213541035824 0.956637332055185 -0.0106795252457266 0.993398701750218 mirMAP -0.118457212505085 0.000726831525567633 NA NA NA hsa-miR-29b-3p BIRC2 -0.104016192263954 0.958988036765397 -0.0106795252457266 0.993398701750218 MirTarget -0.0666511845903626 0.014556143152548 NA NA NA hsa-miR-421 BIRC2 -0.182032017078616 0.734704500318599 -0.0106795252457266 0.993398701750218 miRanda -0.0542651045221302 0.0391384545819839 NA NA NA hsa-miR-500a-5p BIRC2 -0.71978560736831 0.188073776225276 -0.0106795252457266 0.993398701750218 MirTarget -0.0719159864077366 0.002066371233231 NA NA NA hsa-miR-24-1-5p BIRC3 -0.185440327527663 0.791525781516963 -0.141537792183018 0.897243027958393 MirTarget -0.308965184090704 0.00144701353789959 NA NA NA hsa-miR-24-2-5p BIRC3 -0.0947200031589666 0.920155111594601 -0.141537792183018 0.897243027958393 MirTarget -0.210493554284107 0.0414015563094893 NA NA NA hsa-miR-374a-5p BIRC3 -0.343007247142618 0.766921280269271 -0.141537792183018 0.897243027958393 mirMAP -0.227967585085823 0.0476739529258206 NA NA NA hsa-miR-374b-5p BIRC3 -0.285682091626878 0.83569830479965 -0.141537792183018 0.897243027958393 mirMAP -0.283254787874368 0.0109156855888322 NA NA NA hsa-miR-651-5p BIRC3 -0.571699708815578 0.172535889612301 -0.141537792183018 0.897243027958393 MirTarget -0.162521309985949 0.00706165901458035 NA NA NA hsa-miR-20a-3p CAPN2 0.456808229166028 0.57674056136504 0.0419450866249376 0.981485804916366 MirTarget -0.108106917803323 0.00146092490218196 NA NA NA hsa-miR-421 CAPN2 -0.182032017078616 0.734704500318599 0.0419450866249376 0.981485804916366 miRanda -0.251742166674529 3.20703831647803e-08 NA NA NA hsa-miR-7-5p CAPN2 0.209645143210379 0.773705612298441 0.0419450866249376 0.981485804916366 miRNAWalker2_validate -0.117773166189262 9.87489283744295e-05 NA NA NA hsa-miR-125b-5p CASP10 0.042694645848468 0.980586836124662 -0.286859095851538 0.807133415486649 mirMAP -0.0906302761781883 0.0223259020362948 NA NA NA hsa-miR-129-5p CASP10 0.268577986151378 0.553351908525147 -0.286859095851538 0.807133415486649 mirMAP -0.0687761351807497 0.0414094164570609 NA NA NA hsa-miR-145-3p CASP10 0.134827892912136 0.913156302847575 -0.286859095851538 0.807133415486649 mirMAP -0.134274491196889 0.025037224830481 NA NA NA hsa-miR-181c-5p CASP10 0.042951891660695 0.969159991881861 -0.286859095851538 0.807133415486649 mirMAP -0.15340907917641 0.00318018728342029 NA NA NA hsa-miR-217 CASP10 0.341080669095094 0.760998144794468 -0.286859095851538 0.807133415486649 mirMAP -0.0753800675707423 0.0437928357789903 NA NA NA hsa-miR-592 CASP10 -0.177670083168544 0.856226890424691 -0.286859095851538 0.807133415486649 miRNATAP -0.0560721735942251 0.00745924330674229 NA NA NA hsa-let-7c-5p CASP3 -0.0629831812743404 0.974895834249241 -0.162965782047655 0.903158908366085 MirTarget -0.0896132088425543 0.000559568881819448 NA NA NA hsa-miR-129-5p CASP3 0.268577986151378 0.553351908525147 -0.162965782047655 0.903158908366085 mirMAP -0.0561626038843788 0.0129250126528224 23744359 The intrinsic apoptotic pathway triggered by miR-129 was activated by cleavage of caspase-9 and caspase-3 colorectal cancer hsa-miR-139-5p CASP3 -0.0810891026597322 0.928690377743652 -0.162965782047655 0.903158908366085 miRanda -0.0775114646456377 0.0248103829164982 NA NA NA hsa-miR-195-3p CASP3 0.122473158217745 0.691917127032363 -0.162965782047655 0.903158908366085 MirTarget -0.0643054695087654 0.0363313394727987 NA NA NA hsa-miR-30a-5p CASP3 0.219472325612346 0.933954023293816 -0.162965782047655 0.903158908366085 miRNATAP -0.203229832372977 5.73122351633379e-05 NA NA NA hsa-miR-125a-3p CASP6 0.14689780893708 0.724764670752407 -0.203384948580013 0.874967418913192 miRanda -0.0836243555251324 0.0194231032942911 NA NA NA hsa-miR-125a-5p CASP6 -0.00183986061615382 0.999158100170883 -0.203384948580013 0.874967418913192 miRanda -0.134110590798521 0.0225245698105343 NA NA NA hsa-miR-129-5p CASP8 0.268577986151378 0.553351908525147 -0.268951646645792 0.828588317117104 miRanda -0.0534914954127195 0.00484222689600729 NA NA NA hsa-miR-143-3p CASP8 0.371591944134735 0.927341352649583 -0.268951646645792 0.828588317117104 MirTarget -0.109420620201972 0.000545823380266859 NA NA NA hsa-miR-130b-3p CFLAR -0.221667315324818 0.824660172394714 -0.0613591175648374 0.961399997619075 mirMAP -0.173341915965256 4.40375106449909e-08 NA NA NA hsa-miR-15b-5p CFLAR -0.272614787130877 0.87096541832188 -0.0613591175648374 0.961399997619075 mirMAP -0.0919911723981782 0.00996324503783982 NA NA NA hsa-miR-16-5p CFLAR 0.0135949734723564 0.994476223855607 -0.0613591175648374 0.961399997619075 mirMAP -0.0814818438085991 0.0222711466476597 NA NA NA hsa-miR-2110 CFLAR -0.317803483266315 0.250981343062022 -0.0613591175648374 0.961399997619075 MirTarget -0.0644093253932057 0.0357566638657099 NA NA NA hsa-miR-301a-3p CFLAR -0.105312511901769 0.831686745977347 -0.0613591175648374 0.961399997619075 mirMAP -0.098116504391348 0.000316836244688531 NA NA NA hsa-miR-30c-1-3p CFLAR -0.202466672579761 0.511485842123022 -0.0613591175648374 0.961399997619075 mirMAP -0.0781457272477797 0.00392131984879565 NA NA NA hsa-miR-339-5p CFLAR -0.300425087100667 0.712912847076788 -0.0613591175648374 0.961399997619075 miRanda -0.0754008176957066 0.00348335138063452 NA NA NA hsa-miR-374a-5p CFLAR -0.343007247142618 0.766921280269271 -0.0613591175648374 0.961399997619075 MirTarget -0.102997820497686 0.0228122425807299 NA NA NA hsa-miR-374b-5p CFLAR -0.285682091626878 0.83569830479965 -0.0613591175648374 0.961399997619075 MirTarget -0.155358286185632 0.000353399655735518 NA NA NA hsa-miR-421 CFLAR -0.182032017078616 0.734704500318599 -0.0613591175648374 0.961399997619075 miRanda -0.113191277664472 0.000158299555763676 NA NA NA hsa-miR-454-3p CFLAR -0.101514866328011 0.843545158256191 -0.0613591175648374 0.961399997619075 mirMAP -0.0975467470664383 0.00970333128967492 NA NA NA hsa-miR-484 CFLAR -0.179977202691249 0.886333755572375 -0.0613591175648374 0.961399997619075 mirMAP -0.0967320870835921 0.0143083688486345 NA NA NA hsa-miR-660-5p CFLAR -0.476129334484339 0.694082832658925 -0.0613591175648374 0.961399997619075 mirMAP -0.0796724451768832 0.0141603186294957 NA NA NA hsa-miR-1254 CHP2 -0.488929355953681 0.19551794273322 1.46960089468565 0.154796703887396 miRNATAP -0.409969255083918 0.024450757326671 NA NA NA hsa-miR-152-3p CHUK 0.203532896690202 0.90975730233375 -0.096549775668116 0.93218060129343 MirTarget -0.104036949325739 0.0402838317128525 NA NA NA hsa-miR-23b-3p CHUK -0.10822254818704 0.961352920317636 -0.096549775668116 0.93218060129343 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.136584882734319 0.00997084019729046 NA NA NA hsa-miR-339-5p CHUK -0.300425087100667 0.712912847076788 -0.096549775668116 0.93218060129343 miRanda -0.0636333727852685 0.00768153203064703 NA NA NA hsa-miR-376c-3p CHUK 0.310149183310886 0.558689295035779 -0.096549775668116 0.93218060129343 MirTarget -0.0737302273639341 0.00486194222744317 NA NA NA hsa-miR-497-5p CHUK -0.0120217191428731 0.989147225742026 -0.096549775668116 0.93218060129343 MirTarget -0.0996344629146401 0.00509588641249142 NA NA NA hsa-miR-15b-3p CSF2RB -0.557749208157585 0.609181305423188 -0.424243791231997 0.608009754706655 mirMAP -0.556320542920735 1.69990147768674e-07 NA NA NA hsa-miR-186-5p CSF2RB -0.318786974828757 0.85412722938961 -0.424243791231997 0.608009754706655 mirMAP -0.525426499153246 0.000371798037133893 NA NA NA hsa-miR-19a-3p CSF2RB -0.206793507801887 0.844637784802316 -0.424243791231997 0.608009754706655 MirTarget -0.505159885757328 3.13732608161195e-09 NA NA NA hsa-miR-19b-3p CSF2RB -0.0268530183621474 0.986656783046572 -0.424243791231997 0.608009754706655 MirTarget -0.674202290730517 2.38029074307712e-11 NA NA NA hsa-miR-30b-3p CSF2RB -0.514644352757504 0.162424853398397 -0.424243791231997 0.608009754706655 MirTarget -0.432501376695226 2.00030751491199e-05 NA NA NA hsa-miR-452-3p CSF2RB -0.167134177977311 0.799008246175244 -0.424243791231997 0.608009754706655 mirMAP -0.426783979867021 4.47079759509159e-09 NA NA NA hsa-miR-532-5p CSF2RB -0.349665553500088 0.878948352437467 -0.424243791231997 0.608009754706655 MirTarget -0.370796066761641 0.000414661072596092 NA NA NA hsa-miR-576-5p CSF2RB -0.506413219377403 0.417187951364173 -0.424243791231997 0.608009754706655 miRNATAP -0.357189326802445 0.000704779079248235 NA NA NA hsa-miR-590-3p CSF2RB -0.279244755376859 0.59126669933662 -0.424243791231997 0.608009754706655 miRanda;mirMAP -0.393241297046802 6.12226396413448e-06 NA NA NA hsa-miR-625-5p CSF2RB -0.690759472145277 0.210306534567564 -0.424243791231997 0.608009754706655 MirTarget -0.28968042535212 0.000169238256842656 NA NA NA hsa-miR-139-5p CYCS -0.0810891026597322 0.928690377743652 -0.0801546909855499 0.965739955684414 miRanda -0.180455845650641 6.81104021035486e-05 NA NA NA hsa-miR-20b-5p CYCS 0.153132605717463 0.743579022969526 -0.0801546909855499 0.965739955684414 mirMAP -0.0584178576229491 0.0403680420861812 NA NA NA hsa-miR-34c-3p CYCS -0.0677097368202059 0.825448151326958 -0.0801546909855499 0.965739955684414 mirMAP -0.100294994424538 0.00799698860616829 NA NA NA hsa-miR-34c-5p CYCS -0.018707656771723 0.952788306178575 -0.0801546909855499 0.965739955684414 miRanda -0.158065264009806 0.000330182557876286 NA NA NA hsa-miR-127-3p DFFA 0.0756694410683956 0.972625730635758 -0.286184108412671 0.79394722058605 miRanda -0.0890115005125337 0.0243282799408683 NA NA NA hsa-miR-129-5p DFFA 0.268577986151378 0.553351908525147 -0.286184108412671 0.79394722058605 miRanda;mirMAP -0.0500400025345298 0.0208778793766622 NA NA NA hsa-miR-145-5p DFFA 0.0379358609701441 0.987582252034037 -0.286184108412671 0.79394722058605 miRNAWalker2_validate;miRTarBase -0.0902981136057966 0.00132157384617095 NA NA NA hsa-miR-26a-5p DFFA 0.00698202897993028 0.997719986197021 -0.286184108412671 0.79394722058605 mirMAP -0.168274500452959 0.0068437272660124 NA NA NA hsa-miR-30a-3p DFFA 0.250338313897394 0.917094926793447 -0.286184108412671 0.79394722058605 mirMAP -0.15330990955248 0.000342001437069929 NA NA NA hsa-miR-34c-5p DFFA -0.018707656771723 0.952788306178575 -0.286184108412671 0.79394722058605 miRanda -0.107013929351907 0.000766413071466021 NA NA NA hsa-miR-377-5p DFFA -0.178045191012069 0.59428871802001 -0.286184108412671 0.79394722058605 mirMAP -0.0630035458000909 0.0158755630942767 NA NA NA hsa-miR-664a-3p DFFA -0.00395670341813714 0.996119749372707 -0.286184108412671 0.79394722058605 mirMAP -0.14037347665929 0.000427317567574411 NA NA NA hsa-miR-199a-5p DFFB 0.157247797504494 0.935797462797012 -0.384618702135849 0.657881057629234 miRanda -0.0828763264251134 0.0347988797734851 NA NA NA hsa-miR-365a-3p DFFB 0.0797451871548276 0.938758494058574 -0.384618702135849 0.657881057629234 MirTarget -0.0875159129666717 0.0483620868650032 NA NA NA hsa-miR-1275 ENDOD1 -0.831342050607648 0.0803795852164229 0.0425516652586362 0.973765218340755 MirTarget -0.0619984591362171 0.0243904558741193 NA NA NA hsa-miR-16-1-3p ENDOD1 0.151694812889216 0.733736501874638 0.0425516652586362 0.973765218340755 mirMAP -0.0837576887730533 0.0297508948269539 NA NA NA hsa-miR-181d-5p ENDOD1 0.14926527647499 0.888000971478017 0.0425516652586362 0.973765218340755 MirTarget -0.0996980938779077 0.00529704447671425 NA NA NA hsa-miR-193a-3p ENDOD1 -0.247265785363732 0.654363581941634 0.0425516652586362 0.973765218340755 miRanda -0.102986283206002 0.0120079635081056 NA NA NA hsa-miR-19a-3p ENDOD1 -0.206793507801887 0.844637784802316 0.0425516652586362 0.973765218340755 mirMAP -0.122963065450002 0.00066314640646562 NA NA NA hsa-miR-19b-3p ENDOD1 -0.0268530183621474 0.986656783046572 0.0425516652586362 0.973765218340755 mirMAP -0.165048640654556 0.000126182776117063 NA NA NA hsa-miR-20a-3p ENDOD1 0.456808229166028 0.57674056136504 0.0425516652586362 0.973765218340755 MirTarget -0.10361772928502 0.000629639913459516 NA NA NA hsa-miR-335-3p ENDOD1 -0.244830745789445 0.88450019116631 0.0425516652586362 0.973765218340755 MirTarget -0.111195490010087 0.00518202798660825 NA NA NA hsa-miR-450b-5p ENDOD1 -0.0136687538973108 0.983149761399849 0.0425516652586362 0.973765218340755 MirTarget;mirMAP -0.120468654825167 0.00808480426752155 NA NA NA hsa-miR-454-3p ENDOD1 -0.101514866328011 0.843545158256191 0.0425516652586362 0.973765218340755 MirTarget -0.153376783661297 0.00321362308379351 NA NA NA hsa-miR-548o-3p ENDOD1 -0.191447572716994 0.517725546183501 0.0425516652586362 0.973765218340755 mirMAP -0.0901438659925401 0.0240504451697519 NA NA NA hsa-miR-106a-5p FAS -0.203919267842652 0.802213958426804 -0.347166376396346 0.702810017457386 miRNAWalker2_validate;miRTarBase -0.309397365527179 1.69760652678533e-06 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-361-5p FAS -0.138735309928775 0.941495130308343 -0.347166376396346 0.702810017457386 miRanda -0.421714311791871 0.000155426639121472 NA NA NA hsa-miR-491-5p FAS -0.585652105321328 0.0452620602586908 -0.347166376396346 0.702810017457386 miRanda -0.128974045740494 0.0300756948742401 NA NA NA hsa-miR-590-5p FAS -0.547819833829572 0.472735645776647 -0.347166376396346 0.702810017457386 miRanda -0.168205409634763 0.00402598857592482 NA NA NA hsa-miR-98-5p FAS -0.168162186023221 0.898802461503524 -0.347166376396346 0.702810017457386 miRNAWalker2_validate -0.378145247947084 2.09454221266366e-05 NA NA NA hsa-miR-452-3p FASLG -0.167134177977311 0.799008246175244 -1.01623663960814 0.0497518030689545 mirMAP -0.300498727144317 0.000506966650214745 NA NA NA hsa-miR-92a-3p FASLG 0.0278830870766349 0.993247426671713 -1.01623663960814 0.0497518030689545 miRNATAP -0.376276337966714 0.00278748481239554 NA NA NA hsa-miR-320c IKBKG -0.577462251570141 0.113597318870228 0.160937913292935 0.878809002436304 mirMAP -0.085701942677479 0.00184628779200834 NA NA NA hsa-miR-330-3p IKBKG 0.00298687748748416 0.994504006750491 0.160937913292935 0.878809002436304 mirMAP -0.0902891457843034 0.0182565961180783 NA NA NA hsa-miR-181c-5p IL1A 0.042951891660695 0.969159991881861 -0.00744956136028625 0.988885751359075 MirTarget -0.293367366758998 0.0493600441496303 NA NA NA hsa-miR-30b-5p IL1A -0.0121430518253582 0.994622896704513 -0.00744956136028625 0.988885751359075 MirTarget -0.30460053800067 0.0296300035289089 NA NA NA hsa-miR-30e-5p IL1A -0.0657075181381011 0.979684509181941 -0.00744956136028625 0.988885751359075 MirTarget -0.499818466082229 0.0243764666137913 NA NA NA hsa-miR-335-5p IL1A -0.0284895175847679 0.973380867832231 -0.00744956136028625 0.988885751359075 miRNAWalker2_validate -0.279489731033633 0.0323293973333486 NA NA NA hsa-miR-30a-3p IL1B 0.250338313897394 0.917094926793447 -0.516626292182689 0.576037620882043 MirTarget -0.416182084233384 0.016498824808104 NA NA NA hsa-miR-126-5p IL1R1 0.0815213541035824 0.956637332055185 0.0971978498625941 0.931380268505521 mirMAP -0.239373326961859 0.0222388073555939 NA NA NA hsa-miR-130b-5p IL1R1 -0.6472141103776 0.379096015222509 0.0971978498625941 0.931380268505521 mirMAP -0.597849986911064 5.11784999134223e-16 NA NA NA hsa-miR-140-5p IL1R1 -0.229213026275906 0.847330111738616 0.0971978498625941 0.931380268505521 miRanda -0.278572888657444 0.0195405695146059 NA NA NA hsa-miR-17-3p IL1R1 0.100221625453134 0.960113387014848 0.0971978498625941 0.931380268505521 mirMAP -0.54511908545044 5.99236041868129e-12 NA NA NA hsa-miR-181b-5p IL1R1 0.155313039554487 0.930176779696506 0.0971978498625941 0.931380268505521 mirMAP -0.191571605395093 0.0462846201677917 NA NA NA hsa-miR-186-5p IL1R1 -0.318786974828757 0.85412722938961 0.0971978498625941 0.931380268505521 mirMAP -0.76373595274815 2.23069407996303e-12 NA NA NA hsa-miR-192-5p IL1R1 -0.117345487848223 0.972927287653137 0.0971978498625941 0.931380268505521 miRNAWalker2_validate -0.521064610824822 2.08223348177442e-18 NA NA NA hsa-miR-197-3p IL1R1 -0.455489147957159 0.794916582095149 0.0971978498625941 0.931380268505521 miRNAWalker2_validate -0.449558594621509 1.86929045400014e-07 NA NA NA hsa-miR-215-5p IL1R1 -0.142648109361913 0.94480931294964 0.0971978498625941 0.931380268505521 miRNAWalker2_validate -0.126995092092766 0.00191347086429665 NA NA NA hsa-miR-24-3p IL1R1 -0.0484778924256624 0.985274054814493 0.0971978498625941 0.931380268505521 miRNATAP -0.603457361426173 0.000199088441297218 NA NA NA hsa-miR-26b-5p IL1R1 -0.0245931278499594 0.990377966314923 0.0971978498625941 0.931380268505521 mirMAP -0.726194062963501 2.40186470051492e-12 NA NA NA hsa-miR-30d-3p IL1R1 -0.123474741320298 0.814905367625791 0.0971978498625941 0.931380268505521 mirMAP -0.633771957362426 1.5127976345712e-13 NA NA NA hsa-miR-30e-3p IL1R1 -0.220498559176349 0.938660731870214 0.0971978498625941 0.931380268505521 mirMAP -0.344295212564008 0.0213840379216439 NA NA NA hsa-miR-335-3p IL1R1 -0.244830745789445 0.88450019116631 0.0971978498625941 0.931380268505521 mirMAP -0.54040951986299 1.03169031216036e-14 NA NA NA hsa-miR-361-5p IL1R1 -0.138735309928775 0.941495130308343 0.0971978498625941 0.931380268505521 miRanda -0.657872921900768 1.10573544927298e-06 NA NA NA hsa-miR-491-5p IL1R1 -0.585652105321328 0.0452620602586908 0.0971978498625941 0.931380268505521 miRanda -0.217319722631291 0.00269495220336367 NA NA NA hsa-miR-548o-3p IL1R1 -0.191447572716994 0.517725546183501 0.0971978498625941 0.931380268505521 mirMAP -0.315827960543417 1.61184818710973e-05 NA NA NA hsa-miR-590-3p IL1R1 -0.279244755376859 0.59126669933662 0.0971978498625941 0.931380268505521 miRanda;miRNATAP -0.491268245890511 1.60582758504113e-14 NA NA NA hsa-let-7f-2-3p IL1RAP -0.0455032713433074 0.882115725419367 0.160675392694305 0.831548529623142 MirTarget -0.143957447514746 0.000223258886839442 NA NA NA hsa-miR-106a-5p IL1RAP -0.203919267842652 0.802213958426804 0.160675392694305 0.831548529623142 MirTarget -0.191209658239253 1.85074870272663e-05 NA NA NA hsa-miR-106b-5p IL1RAP -0.297128724729339 0.869294443540749 0.160675392694305 0.831548529623142 MirTarget -0.22683139900241 1.12618261166573e-05 NA NA NA hsa-miR-130a-3p IL1RAP 0.0910074087716906 0.929098200371948 0.160675392694305 0.831548529623142 MirTarget -0.181371247466266 0.000103811850845334 NA NA NA hsa-miR-130b-3p IL1RAP -0.221667315324818 0.824660172394714 0.160675392694305 0.831548529623142 MirTarget -0.221022135841534 1.66111023280578e-06 NA NA NA hsa-miR-140-5p IL1RAP -0.229213026275906 0.847330111738616 0.160675392694305 0.831548529623142 miRanda -0.219834909432766 0.000958228682157065 NA NA NA hsa-miR-142-3p IL1RAP -0.154235241441331 0.946098054588918 0.160675392694305 0.831548529623142 miRanda -0.0803475815683489 0.031636787578617 NA NA NA hsa-miR-17-5p IL1RAP -0.175448849583061 0.934544015912731 0.160675392694305 0.831548529623142 MirTarget;TargetScan -0.167083380776715 2.24340063359446e-05 NA NA NA hsa-miR-186-5p IL1RAP -0.318786974828757 0.85412722938961 0.160675392694305 0.831548529623142 mirMAP -0.215436006186164 0.000723436159590429 NA NA NA hsa-miR-192-5p IL1RAP -0.117345487848223 0.972927287653137 0.160675392694305 0.831548529623142 miRNAWalker2_validate -0.130876760847657 0.000261025518657414 NA NA NA hsa-miR-199b-5p IL1RAP -0.0396557270992508 0.977172718873203 0.160675392694305 0.831548529623142 miRanda -0.0980687924891064 0.0265190527892291 NA NA NA hsa-miR-19a-3p IL1RAP -0.206793507801887 0.844637784802316 0.160675392694305 0.831548529623142 MirTarget -0.169817189194384 5.47943782915461e-06 NA NA NA hsa-miR-19b-3p IL1RAP -0.0268530183621474 0.986656783046572 0.160675392694305 0.831548529623142 MirTarget -0.169145163821916 0.000171747903012152 NA NA NA hsa-miR-20a-5p IL1RAP -0.179153323927949 0.928118119139752 0.160675392694305 0.831548529623142 MirTarget -0.135143648023773 0.000546968419998277 NA NA NA hsa-miR-217 IL1RAP 0.341080669095094 0.760998144794468 0.160675392694305 0.831548529623142 miRanda -0.070688248548111 0.0388979087637844 NA NA NA hsa-miR-224-3p IL1RAP 0.110372723153393 0.749091467231007 0.160675392694305 0.831548529623142 MirTarget -0.111832100082262 0.00205907823590406 NA NA NA hsa-miR-29a-3p IL1RAP 0.01127474410284 0.996977020481272 0.160675392694305 0.831548529623142 MirTarget;miRNATAP -0.189900879878914 0.00146794004616984 NA NA NA hsa-miR-29b-3p IL1RAP -0.104016192263954 0.958988036765397 0.160675392694305 0.831548529623142 MirTarget;miRNATAP -0.207537091842477 3.31119368573026e-06 NA NA NA hsa-miR-301a-3p IL1RAP -0.105312511901769 0.831686745977347 0.160675392694305 0.831548529623142 MirTarget -0.110801422785086 0.00515676532544119 NA NA NA hsa-miR-335-3p IL1RAP -0.244830745789445 0.88450019116631 0.160675392694305 0.831548529623142 mirMAP -0.126935389314144 0.00221953478927472 NA NA NA hsa-miR-339-5p IL1RAP -0.300425087100667 0.712912847076788 0.160675392694305 0.831548529623142 miRanda -0.157548289284125 1.95582183274076e-05 NA NA NA hsa-miR-362-3p IL1RAP -0.721040238345347 0.0345881362485733 0.160675392694305 0.831548529623142 miRanda -0.122157232448564 0.000940585501855135 NA NA NA hsa-miR-421 IL1RAP -0.182032017078616 0.734704500318599 0.160675392694305 0.831548529623142 MirTarget;miRanda -0.14393848910528 0.000929642182093677 NA NA NA hsa-miR-454-3p IL1RAP -0.101514866328011 0.843545158256191 0.160675392694305 0.831548529623142 MirTarget -0.174325214931229 0.0013240928608515 NA NA NA hsa-miR-576-5p IL1RAP -0.506413219377403 0.417187951364173 0.160675392694305 0.831548529623142 mirMAP -0.17059562065834 0.000166778354203674 NA NA NA hsa-miR-577 IL1RAP -1.06238199218774 0.326056761787754 0.160675392694305 0.831548529623142 mirMAP -0.0726146021831137 0.0021294394765725 NA NA NA hsa-miR-590-3p IL1RAP -0.279244755376859 0.59126669933662 0.160675392694305 0.831548529623142 MirTarget;miRanda;mirMAP -0.137014180275726 0.000289189242093682 NA NA NA hsa-miR-590-5p IL1RAP -0.547819833829572 0.472735645776647 0.160675392694305 0.831548529623142 miRanda -0.206981550022239 1.40879946161304e-07 NA NA NA hsa-miR-7-1-3p IL1RAP -0.462485777435991 0.665899751398166 0.160675392694305 0.831548529623142 MirTarget -0.119783168396852 0.00722481327087485 NA NA NA hsa-miR-93-5p IL1RAP -0.611073677204699 0.825297877093193 0.160675392694305 0.831548529623142 MirTarget -0.148566202859431 0.00262519781442786 NA NA NA hsa-miR-95-3p IL1RAP -0.0818004840634243 0.924053102559599 0.160675392694305 0.831548529623142 MirTarget -0.107032389017763 0.00158073977211462 NA NA NA hsa-miR-362-3p IL3RA -0.721040238345347 0.0345881362485733 0.163928312094029 0.804758258942851 miRanda -0.169156809721412 0.00190481779053269 NA NA NA hsa-miR-146a-5p IRAK1 -0.581292803346906 0.73685134936757 0.084323356691633 0.963335362026959 miRNAWalker2_validate;miRTarBase -0.0769862020161253 0.0224047624272363 25242818;22846912;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;Functional analysis revealed that miR-146a rs2910164 C allele inhibited cell proliferation and significantly downregulated expression of IRAK1 and TRAF6 in bladder cancer cells;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;; pancreatic cancer;bladder cancer;gastric cancer hsa-miR-330-5p IRAK1 -0.283418953659271 0.815687101334695 0.084323356691633 0.963335362026959 miRNAWalker2_validate -0.197496743914743 0.000137818885389644 NA NA NA hsa-miR-335-5p IRAK2 -0.0284895175847679 0.973380867832231 -0.262923936467092 0.771444932972343 miRNAWalker2_validate -0.167792773902635 0.0223001611855779 NA NA NA hsa-miR-141-3p IRAK3 -0.31994058840327 0.87774106909065 0.129331135700148 0.833494953850949 mirMAP -0.465426995904877 3.51591599318979e-10 NA NA NA hsa-miR-148b-5p IRAK3 -0.236618793990305 0.43925706879726 0.129331135700148 0.833494953850949 mirMAP -0.264576206209992 0.00135007642446132 NA NA NA hsa-miR-16-1-3p IRAK3 0.151694812889216 0.733736501874638 0.129331135700148 0.833494953850949 mirMAP -0.259652841527637 0.00108866630766155 NA NA NA hsa-miR-16-2-3p IRAK3 -0.36717860153421 0.546850726070016 0.129331135700148 0.833494953850949 mirMAP -0.366374149356245 7.8385784516044e-06 NA NA NA hsa-miR-16-5p IRAK3 0.0135949734723564 0.994476223855607 0.129331135700148 0.833494953850949 miRNAWalker2_validate -0.397299409262029 8.66739899564317e-05 NA NA NA hsa-miR-186-5p IRAK3 -0.318786974828757 0.85412722938961 0.129331135700148 0.833494953850949 mirMAP -0.413817823283351 0.00109544230842425 NA NA NA hsa-miR-188-5p IRAK3 -0.568517670542551 0.324820848307954 0.129331135700148 0.833494953850949 mirMAP -0.346399236116401 1.18313475327637e-07 NA NA NA hsa-miR-200a-3p IRAK3 -0.367034437440907 0.851059894150266 0.129331135700148 0.833494953850949 mirMAP -0.385739967241973 1.35303542299515e-07 NA NA NA hsa-miR-20a-3p IRAK3 0.456808229166028 0.57674056136504 0.129331135700148 0.833494953850949 mirMAP -0.338637800764729 3.9467090370602e-08 NA NA NA hsa-miR-224-3p IRAK3 0.110372723153393 0.749091467231007 0.129331135700148 0.833494953850949 mirMAP -0.161487069355648 0.0258990900320469 NA NA NA hsa-miR-25-3p IRAK3 -0.457540448732733 0.878574066837636 0.129331135700148 0.833494953850949 mirMAP -0.538542703139969 1.88617082799896e-05 NA NA NA hsa-miR-32-5p IRAK3 -0.05993267619119 0.952975951594959 0.129331135700148 0.833494953850949 mirMAP -0.417640631571904 1.57549496387142e-06 NA NA NA hsa-miR-320a IRAK3 -0.416546433767628 0.840202138616422 0.129331135700148 0.833494953850949 miRanda -0.325022057848163 0.00255822915515794 NA NA NA hsa-miR-320b IRAK3 -0.23561798088153 0.859222532827992 0.129331135700148 0.833494953850949 miRanda -0.237948765214069 0.0142584200688331 NA NA NA hsa-miR-324-5p IRAK3 -0.50063248413014 0.537416710557032 0.129331135700148 0.833494953850949 miRanda -0.43679993953373 3.31909975599297e-06 NA NA NA hsa-miR-335-3p IRAK3 -0.244830745789445 0.88450019116631 0.129331135700148 0.833494953850949 mirMAP -0.409653481443299 4.18935271469258e-07 NA NA NA hsa-miR-33a-5p IRAK3 -0.205788753603336 0.853314500865147 0.129331135700148 0.833494953850949 mirMAP -0.23947658972329 6.06023958751047e-07 NA NA NA hsa-miR-33b-5p IRAK3 -0.161971614375297 0.737436207821109 0.129331135700148 0.833494953850949 mirMAP -0.245120333016334 4.46760457245626e-06 NA NA NA hsa-miR-361-5p IRAK3 -0.138735309928775 0.941495130308343 0.129331135700148 0.833494953850949 miRanda;mirMAP -0.3731116564816 0.0152238444252403 NA NA NA hsa-miR-374a-3p IRAK3 -0.118320910531011 0.958176637009264 0.129331135700148 0.833494953850949 mirMAP -0.18178813821466 0.0456032033182177 NA NA NA hsa-miR-374a-5p IRAK3 -0.343007247142618 0.766921280269271 0.129331135700148 0.833494953850949 mirMAP -0.306825097694337 0.0181723897834323 NA NA NA hsa-miR-374b-5p IRAK3 -0.285682091626878 0.83569830479965 0.129331135700148 0.833494953850949 mirMAP -0.463327217900918 0.000204263226960193 NA NA NA hsa-miR-376a-5p IRAK3 0.0978680856849549 0.773217338913054 0.129331135700148 0.833494953850949 mirMAP -0.164019702264181 0.0388894687530141 NA NA NA hsa-miR-421 IRAK3 -0.182032017078616 0.734704500318599 0.129331135700148 0.833494953850949 miRanda;mirMAP -0.3616958188324 2.45003123007711e-05 NA NA NA hsa-miR-429 IRAK3 -0.456485631615963 0.806240953400535 0.129331135700148 0.833494953850949 miRanda -0.425758585732957 7.64398672844813e-10 NA NA NA hsa-miR-452-3p IRAK3 -0.167134177977311 0.799008246175244 0.129331135700148 0.833494953850949 mirMAP -0.32921253822962 1.59813580677593e-07 NA NA NA hsa-miR-501-5p IRAK3 -0.834032628506285 0.0582725160418523 0.129331135700148 0.833494953850949 mirMAP -0.240553834358301 0.000323581506933706 NA NA NA hsa-miR-505-3p IRAK3 -0.469094267152605 0.690382680489578 0.129331135700148 0.833494953850949 mirMAP -0.472467317865043 1.11943278345456e-05 NA NA NA hsa-miR-577 IRAK3 -1.06238199218774 0.326056761787754 0.129331135700148 0.833494953850949 mirMAP -0.270286536956 3.18755843416807e-09 NA NA NA hsa-miR-582-5p IRAK3 -0.399450205475138 0.581227478860085 0.129331135700148 0.833494953850949 mirMAP -0.239243142798065 0.0149268334434111 NA NA NA hsa-miR-589-3p IRAK3 -0.835836305204965 0.0112001563801511 0.129331135700148 0.833494953850949 mirMAP -0.238744109082446 0.000657563114442049 NA NA NA hsa-miR-590-3p IRAK3 -0.279244755376859 0.59126669933662 0.129331135700148 0.833494953850949 miRanda;mirMAP -0.352883933624394 2.05342611467168e-06 NA NA NA hsa-miR-590-5p IRAK3 -0.547819833829572 0.472735645776647 0.129331135700148 0.833494953850949 mirMAP -0.49643899767587 1.09709493119848e-10 NA NA NA hsa-miR-660-5p IRAK3 -0.476129334484339 0.694082832658925 0.129331135700148 0.833494953850949 mirMAP -0.421351949576795 4.33625288903982e-06 NA NA NA hsa-miR-7-1-3p IRAK3 -0.462485777435991 0.665899751398166 0.129331135700148 0.833494953850949 mirMAP -0.297057942845784 0.000756660155946671 NA NA NA hsa-miR-92a-3p IRAK3 0.0278830870766349 0.993247426671713 0.129331135700148 0.833494953850949 mirMAP -0.493472769653974 5.73878060234433e-08 NA NA NA hsa-miR-320a IRAK4 -0.416546433767628 0.840202138616422 0.265455844077453 0.801341521138687 miRanda -0.0849980565239856 0.017706119746901 NA NA NA hsa-miR-320b IRAK4 -0.23561798088153 0.859222532827992 0.265455844077453 0.801341521138687 miRanda -0.107386784856994 0.000783409013485639 NA NA NA hsa-miR-429 MAP3K14 -0.456485631615963 0.806240953400535 -0.0510044597355082 0.960373662039474 miRNATAP -0.0900312538036641 0.00121867168022475 NA NA NA hsa-miR-26b-5p NFKB1 -0.0245931278499594 0.990377966314923 -0.225683083758418 0.875174221708563 miRNAWalker2_validate -0.0867140969230495 0.0190298047431537 NA NA NA hsa-miR-143-5p NFKBIA 0.10589969923845 0.933358732923556 0.077065001931901 0.957680876120832 MirTarget -0.0843081135553818 0.0280636870113457 NA NA NA hsa-miR-335-5p NFKBIA -0.0284895175847679 0.973380867832231 0.077065001931901 0.957680876120832 miRNAWalker2_validate -0.13105129059451 0.000423884835448271 NA NA NA hsa-let-7f-1-3p PIK3CA -0.31101436822914 0.693407210545374 0.0225357621933919 0.979422693316883 mirMAP -0.118501081655342 0.0064771514178073 NA NA NA hsa-miR-126-5p PIK3CA 0.0815213541035824 0.956637332055185 0.0225357621933919 0.979422693316883 mirMAP -0.0784148290676484 0.0348200249580203 NA NA NA hsa-miR-146a-5p PIK3CA -0.581292803346906 0.73685134936757 0.0225357621933919 0.979422693316883 mirMAP -0.0854196435963535 0.000403405554736009 NA NA NA hsa-miR-148a-5p PIK3CA -0.448099743845604 0.748419139652266 0.0225357621933919 0.979422693316883 mirMAP -0.112357517651492 7.06215647986463e-05 NA NA NA hsa-miR-148b-3p PIK3CA -0.202106692287125 0.911884960581838 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.117892096365902 0.00490902202717801 NA NA NA hsa-miR-16-2-3p PIK3CA -0.36717860153421 0.546850726070016 0.0225357621933919 0.979422693316883 mirMAP -0.10245614796563 9.13897985797286e-05 NA NA NA hsa-miR-17-5p PIK3CA -0.175448849583061 0.934544015912731 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.115705723770344 3.03228335548689e-06 NA NA NA hsa-miR-186-5p PIK3CA -0.318786974828757 0.85412722938961 0.0225357621933919 0.979422693316883 mirMAP -0.146329134056921 0.000268937701971312 NA NA NA hsa-miR-200b-3p PIK3CA -0.426401948379212 0.863957108574195 0.0225357621933919 0.979422693316883 TargetScan -0.0823121121810096 0.00335026382078715 NA NA NA hsa-miR-29b-1-5p PIK3CA -0.642348119412534 0.293891497238796 0.0225357621933919 0.979422693316883 mirMAP -0.0887948185952627 1.13256342502507e-05 NA NA NA hsa-miR-32-3p PIK3CA -0.568003960723004 0.13133163420273 0.0225357621933919 0.979422693316883 mirMAP -0.112972746252127 2.51225612643757e-08 NA NA NA hsa-miR-320a PIK3CA -0.416546433767628 0.840202138616422 0.0225357621933919 0.979422693316883 miRanda -0.0850056183235649 0.0133603940041426 NA NA NA hsa-miR-335-3p PIK3CA -0.244830745789445 0.88450019116631 0.0225357621933919 0.979422693316883 mirMAP -0.0983662947162228 0.000160166726267841 NA NA NA hsa-miR-335-5p PIK3CA -0.0284895175847679 0.973380867832231 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.10180509768488 9.82755134026126e-05 NA NA NA hsa-miR-339-5p PIK3CA -0.300425087100667 0.712912847076788 0.0225357621933919 0.979422693316883 miRanda -0.103587269763801 8.44655068921029e-06 NA NA NA hsa-miR-374a-5p PIK3CA -0.343007247142618 0.766921280269271 0.0225357621933919 0.979422693316883 mirMAP -0.0956342845335149 0.0205499496196201 NA NA NA hsa-miR-374b-5p PIK3CA -0.285682091626878 0.83569830479965 0.0225357621933919 0.979422693316883 mirMAP -0.142766383581644 0.00032150800529493 NA NA NA hsa-miR-376b-3p PIK3CA -0.00712550627858333 0.982426403308526 0.0225357621933919 0.979422693316883 mirMAP -0.098590284087573 6.32218537841441e-05 NA NA NA hsa-miR-450b-5p PIK3CA -0.0136687538973108 0.983149761399849 0.0225357621933919 0.979422693316883 mirMAP -0.0689299368667129 0.0219215988494366 NA NA NA hsa-miR-495-3p PIK3CA 0.00168200867117596 0.997533662527025 0.0225357621933919 0.979422693316883 mirMAP -0.0939710311083595 0.00971558819041128 NA NA NA hsa-miR-501-5p PIK3CA -0.834032628506285 0.0582725160418523 0.0225357621933919 0.979422693316883 mirMAP -0.110757579310586 1.16330645525834e-07 NA NA NA hsa-miR-576-5p PIK3CA -0.506413219377403 0.417187951364173 0.0225357621933919 0.979422693316883 PITA -0.113974010997229 6.59094941020168e-05 NA NA NA hsa-miR-577 PIK3CA -1.06238199218774 0.326056761787754 0.0225357621933919 0.979422693316883 mirMAP -0.0522775154153292 0.000442837397175666 NA NA NA hsa-miR-582-3p PIK3CA -0.2334649592375 0.897678119160318 0.0225357621933919 0.979422693316883 miRNATAP -0.140113361530972 2.23178585157338e-06 NA NA NA hsa-miR-590-3p PIK3CA -0.279244755376859 0.59126669933662 0.0225357621933919 0.979422693316883 miRanda;mirMAP -0.123897140594567 1.31301452772078e-07 NA NA NA hsa-miR-590-5p PIK3CA -0.547819833829572 0.472735645776647 0.0225357621933919 0.979422693316883 miRanda -0.140125048782077 1.41706046141534e-08 NA NA NA hsa-miR-7-1-3p PIK3CA -0.462485777435991 0.665899751398166 0.0225357621933919 0.979422693316883 mirMAP -0.0842062153917977 0.00273273717657001 NA NA NA hsa-miR-96-5p PIK3CA 0.0854810872029343 0.923087820185031 0.0225357621933919 0.979422693316883 TargetScan -0.128475980855667 9.81905908048452e-08 NA NA NA hsa-miR-130a-3p PIK3CB 0.0910074087716906 0.929098200371948 -0.116646701488769 0.930082812700679 miRNATAP -0.0570685793580696 0.0403719373528991 NA NA NA hsa-miR-199b-3p PIK3CB 0.0780653337513897 0.973815251150337 -0.116646701488769 0.930082812700679 miRNATAP -0.0789472051595232 0.0142752718998668 NA NA NA hsa-miR-9-5p PIK3CB 0.447601333076892 0.795015262386155 -0.116646701488769 0.930082812700679 miRNATAP -0.0583479690423617 0.0011019712624281 NA NA NA hsa-miR-1468-5p PIK3CD -0.200868572236891 0.688408103178562 -0.0499659666229988 0.947033498136668 MirTarget -0.293090508926218 0.000248785469894942 NA NA NA hsa-miR-29a-3p PIK3CD 0.01127474410284 0.996977020481272 -0.0499659666229988 0.947033498136668 mirMAP -0.351166771873915 0.00243536234086878 NA NA NA hsa-miR-29b-3p PIK3CD -0.104016192263954 0.958988036765397 -0.0499659666229988 0.947033498136668 mirMAP -0.263613715224296 0.00266331795083224 NA NA NA hsa-miR-30b-3p PIK3CD -0.514644352757504 0.162424853398397 -0.0499659666229988 0.947033498136668 MirTarget -0.194812090288003 0.0235152186170438 NA NA NA hsa-miR-30b-5p PIK3CD -0.0121430518253582 0.994622896704513 -0.0499659666229988 0.947033498136668 MirTarget -0.395682674717868 3.65190942130723e-06 NA NA NA hsa-miR-30c-5p PIK3CD -0.298383882401475 0.865809030482001 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.419452305097446 0.000712699686404817 NA NA NA hsa-miR-30d-5p PIK3CD -0.168211838771867 0.95173197030375 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.360885227262785 0.00123008895505406 NA NA NA hsa-miR-324-5p PIK3CD -0.50063248413014 0.537416710557032 -0.0499659666229988 0.947033498136668 miRanda -0.19400350900327 0.0378875481163709 NA NA NA hsa-miR-421 PIK3CD -0.182032017078616 0.734704500318599 -0.0499659666229988 0.947033498136668 miRanda -0.48895286723391 2.44692621373687e-09 NA NA NA hsa-miR-484 PIK3CD -0.179977202691249 0.886333755572375 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.351057480112147 0.00143452196121959 NA NA NA hsa-miR-7-5p PIK3CD 0.209645143210379 0.773705612298441 -0.0499659666229988 0.947033498136668 miRTarBase;MirTarget;miRNATAP -0.196228010352377 0.000352590199023202 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-942-5p PIK3CD -0.50502396741886 0.50777904281306 -0.0499659666229988 0.947033498136668 MirTarget -0.192312219113083 0.0086308226579878 NA NA NA hsa-miR-126-3p PIK3CG -0.106293136341574 0.963670566555251 -0.358088978987777 0.469718116584845 miRTarBase -0.534372493039168 0.000484031176443627 NA NA NA hsa-miR-26b-5p PIK3CG -0.0245931278499594 0.990377966314923 -0.358088978987777 0.469718116584845 miRNAWalker2_validate -0.795245028298382 7.45064172731532e-07 NA NA NA hsa-miR-29b-3p PIK3CG -0.104016192263954 0.958988036765397 -0.358088978987777 0.469718116584845 miRTarBase -0.666133284835925 1.9528746633095e-08 NA NA NA hsa-miR-335-3p PIK3CG -0.244830745789445 0.88450019116631 -0.358088978987777 0.469718116584845 mirMAP -0.563949149516835 2.51672261116185e-07 NA NA NA hsa-miR-421 PIK3CG -0.182032017078616 0.734704500318599 -0.358088978987777 0.469718116584845 miRanda -0.444524915857051 0.000133233454665448 NA NA NA hsa-miR-502-5p PIK3CG -0.708507838520586 0.0261309781860104 -0.358088978987777 0.469718116584845 miRNATAP -0.340480467784473 0.000652722824953133 26163264 Phosphoinositide 3-kinase catalytic subunit gamma PIK3CG was identified as a direct downstream target of miR-502 in HCC cells; Notably overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells liver cancer hsa-miR-590-3p PIK3CG -0.279244755376859 0.59126669933662 -0.358088978987777 0.469718116584845 miRanda -0.438492197588501 1.39596666922937e-05 NA NA NA hsa-miR-107 PIK3R1 -0.0365118169251648 0.988364120226869 -0.107670470040419 0.937523599303491 MirTarget;PITA;miRanda;miRNATAP -0.159578315724103 0.0420240332899534 NA NA NA hsa-miR-132-3p PIK3R1 -0.244143673573889 0.871752726220643 -0.107670470040419 0.937523599303491 MirTarget -0.191363026291576 0.00729852053203983 NA NA NA hsa-miR-144-3p PIK3R1 0.0482420655617901 0.935871997593533 -0.107670470040419 0.937523599303491 mirMAP -0.0934561772058072 0.000890783597794107 NA NA NA hsa-miR-144-5p PIK3R1 -0.300173463942009 0.809668168233345 -0.107670470040419 0.937523599303491 mirMAP -0.0940006121934898 0.00372338701133854 NA NA NA hsa-miR-15a-5p PIK3R1 -0.0674049094129128 0.964835434214123 -0.107670470040419 0.937523599303491 MirTarget -0.217108462406312 8.91731617861317e-05 NA NA NA hsa-miR-15b-5p PIK3R1 -0.272614787130877 0.87096541832188 -0.107670470040419 0.937523599303491 MirTarget -0.14300320532504 0.00643583854060318 NA NA NA hsa-miR-16-5p PIK3R1 0.0135949734723564 0.994476223855607 -0.107670470040419 0.937523599303491 MirTarget -0.189731088951203 0.0002621971143127 NA NA NA hsa-miR-185-5p PIK3R1 -0.294432218239008 0.820591478398594 -0.107670470040419 0.937523599303491 miRNATAP -0.23627908813405 0.00027005032337405 NA NA NA hsa-miR-199a-3p PIK3R1 0.0782166873040424 0.973766909565326 -0.107670470040419 0.937523599303491 miRNATAP -0.114702369631033 0.0400244018594487 NA NA NA hsa-miR-199b-3p PIK3R1 0.0780653337513897 0.973815251150337 -0.107670470040419 0.937523599303491 miRNATAP -0.114742586941786 0.0399527963725661 NA NA NA hsa-miR-21-5p PIK3R1 -0.148920887107433 0.970240620972126 -0.107670470040419 0.937523599303491 miRNAWalker2_validate;MirTarget;miRNATAP -0.32048586087571 3.69693869528844e-05 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.0224067199236484 0.973232008101458 -0.107670470040419 0.937523599303491 MirTarget -0.229364822725893 5.39528810633945e-05 NA NA NA hsa-miR-22-5p PIK3R1 -0.0785922550675187 0.93169760098231 -0.107670470040419 0.937523599303491 mirMAP -0.186145388676108 2.66965799007355e-05 NA NA NA hsa-miR-221-3p PIK3R1 0.0906940388127513 0.959121118272534 -0.107670470040419 0.937523599303491 MirTarget -0.197435928682178 0.000527618156345501 NA NA NA hsa-miR-222-3p PIK3R1 -0.0265849318772702 0.984005474689108 -0.107670470040419 0.937523599303491 MirTarget -0.202803725155249 6.41878654683067e-05 NA NA NA hsa-miR-338-5p PIK3R1 0.484769112400393 0.393961930708873 -0.107670470040419 0.937523599303491 PITA -0.0704371279628422 0.0369886705711126 NA NA NA hsa-miR-369-3p PIK3R1 0.116576891957687 0.83230082995912 -0.107670470040419 0.937523599303491 PITA -0.167895129809982 0.000380018195201003 NA NA NA hsa-miR-424-5p PIK3R1 0.247080963500746 0.870154571783568 -0.107670470040419 0.937523599303491 MirTarget -0.119382000204097 0.00203768025896863 NA NA NA hsa-miR-450b-5p PIK3R1 -0.0136687538973108 0.983149761399849 -0.107670470040419 0.937523599303491 miRNATAP -0.190787246019265 6.82791616588e-05 NA NA NA hsa-miR-486-5p PIK3R1 -0.547739229538641 0.696404149927963 -0.107670470040419 0.937523599303491 MirTarget;PITA;miRanda;miRNATAP -0.0883925761776019 0.00458101362563462 25475121 Mechanistically miR-486-5p was confirmed to directly target PIK3R1 expression thereby suppressing phosphatidylinositol 3-kinase-AKT pathway activation by dual luciferase reporter assay and real-time quantitative RT-PCR and western blot analysis; In addition PIK3R1 knockdown mimicked the effects of miR-486-5p overexpression by inhibiting HCC growth migration and invasion; Furthermore correlation analysis Kaplan-Meier estimates and Cox proportional hazard models showed an inverse correlation between miR-486-5p and PIK3R1 as well as a shorter time to recurrence after HCC resection in patients with lower miR-486-5p expression; Hence we conclude that miR-486-5p which is frequently downregulated in HCC inhibits HCC progression by targeting PIK3R1 and phosphatidylinositol 3-kinase-AKT activation recurrence;progression liver cancer hsa-miR-542-3p PIK3R1 0.188168046511374 0.909252939431573 -0.107670470040419 0.937523599303491 MirTarget;PITA;miRanda -0.150969723974234 0.00748950466389255 NA NA NA hsa-miR-548o-3p PIK3R1 -0.191447572716994 0.517725546183501 -0.107670470040419 0.937523599303491 mirMAP -0.106039985326561 0.0124895472954661 NA NA NA hsa-miR-582-5p PIK3R1 -0.399450205475138 0.581227478860085 -0.107670470040419 0.937523599303491 mirMAP -0.142451077115944 0.0045721005781701 NA NA NA hsa-miR-590-3p PIK3R1 -0.279244755376859 0.59126669933662 -0.107670470040419 0.937523599303491 miRanda;mirMAP -0.146401290926594 0.000138874186663878 NA NA NA hsa-miR-590-5p PIK3R1 -0.547819833829572 0.472735645776647 -0.107670470040419 0.937523599303491 MirTarget;PITA;miRanda;miRNATAP -0.15721405103923 0.000108223764424085 NA NA NA hsa-miR-629-3p PIK3R1 -0.495402745812008 0.333967382214384 -0.107670470040419 0.937523599303491 MirTarget -0.0870291469037613 0.0197324469039814 NA NA NA hsa-miR-30a-5p PIK3R2 0.219472325612346 0.933954023293816 -0.297680606771329 0.850152230341952 miRNATAP -0.205862820761505 5.83465711487357e-06 NA NA NA hsa-miR-181c-5p PIK3R3 0.042951891660695 0.969159991881861 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.166375015135553 0.00307339705460455 NA NA NA hsa-miR-181d-5p PIK3R3 0.14926527647499 0.888000971478017 -0.276772749610974 0.793454902449853 MirTarget -0.160008098502222 0.000261018045617695 NA NA NA hsa-miR-18a-3p PIK3R3 -0.270443061178857 0.535291623032886 -0.276772749610974 0.793454902449853 miRNAWalker2_validate -0.0800702871922108 0.0414157115113036 NA NA NA hsa-miR-19a-3p PIK3R3 -0.206793507801887 0.844637784802316 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.116147528359031 0.00952170048888319 NA NA NA hsa-miR-19b-3p PIK3R3 -0.0268530183621474 0.986656783046572 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.194729521448902 0.000250390771046988 NA NA NA hsa-miR-29b-1-5p PIK3R3 -0.642348119412534 0.293891497238796 -0.276772749610974 0.793454902449853 mirMAP -0.0764099547970008 0.0469817340969967 NA NA NA hsa-miR-32-5p PIK3R3 -0.05993267619119 0.952975951594959 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.138065839958076 0.00869251602983598 NA NA NA hsa-miR-323a-3p PIK3R3 0.279126405514894 0.478782330851768 -0.276772749610974 0.793454902449853 mirMAP -0.0944809974488282 0.0413869400448853 NA NA NA hsa-miR-335-3p PIK3R3 -0.244830745789445 0.88450019116631 -0.276772749610974 0.793454902449853 mirMAP -0.200911178812086 3.4951167686824e-05 NA NA NA hsa-miR-339-5p PIK3R3 -0.300425087100667 0.712912847076788 -0.276772749610974 0.793454902449853 MirTarget;miRanda -0.114440753951127 0.00949514702310638 NA NA NA hsa-miR-454-3p PIK3R3 -0.101514866328011 0.843545158256191 -0.276772749610974 0.793454902449853 mirMAP -0.183582040707033 0.00426750044797469 NA NA NA hsa-miR-590-5p PIK3R3 -0.547819833829572 0.472735645776647 -0.276772749610974 0.793454902449853 miRanda -0.117849359871163 0.0132046234736956 NA NA NA hsa-miR-92a-3p PIK3R3 0.0278830870766349 0.993247426671713 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.264671393069774 1.12229021521678e-06 NA NA NA hsa-miR-182-5p PIK3R5 -0.104238497940557 0.973380614062243 -0.266913830275555 0.638823741545427 MirTarget -0.335738588315792 0.000137422868989864 NA NA NA hsa-miR-18a-3p PIK3R5 -0.270443061178857 0.535291623032886 -0.266913830275555 0.638823741545427 MirTarget -0.247792416366587 0.000674544930154222 NA NA NA hsa-miR-106a-5p PPP3CA -0.203919267842652 0.802213958426804 -0.087509752034574 0.946989676888573 miRNATAP -0.0819279142221166 0.0151011719372481 NA NA NA hsa-miR-17-3p PPP3CA 0.100221625453134 0.960113387014848 -0.087509752034574 0.946989676888573 MirTarget -0.0927829795786169 0.0074029836145354 NA NA NA hsa-miR-17-5p PPP3CA -0.175448849583061 0.934544015912731 -0.087509752034574 0.946989676888573 miRNATAP -0.109137738299345 0.000214467204408686 NA NA NA hsa-miR-194-5p PPP3CA -0.159001168846464 0.959682382557336 -0.087509752034574 0.946989676888573 MirTarget -0.0704798843423589 0.0238474597435954 NA NA NA hsa-miR-20a-5p PPP3CA -0.179153323927949 0.928118119139752 -0.087509752034574 0.946989676888573 miRNATAP -0.0887133968447148 0.00237866122425277 NA NA NA hsa-miR-29a-5p PPP3CA -0.31835175571979 0.600442757817281 -0.087509752034574 0.946989676888573 mirMAP;miRNATAP -0.110664225522305 0.000326600214856183 NA NA NA hsa-miR-335-3p PPP3CA -0.244830745789445 0.88450019116631 -0.087509752034574 0.946989676888573 MirTarget -0.158993670541163 1.48991898684692e-07 NA NA NA hsa-miR-361-5p PPP3CA -0.138735309928775 0.941495130308343 -0.087509752034574 0.946989676888573 miRanda -0.181593940934707 0.00153602268336464 NA NA NA hsa-miR-374b-3p PPP3CA -0.0542885924440247 0.860753623992354 -0.087509752034574 0.946989676888573 MirTarget -0.118414724128426 0.00147351846810998 NA NA NA hsa-miR-450b-5p PPP3CA -0.0136687538973108 0.983149761399849 -0.087509752034574 0.946989676888573 PITA;mirMAP;miRNATAP -0.0939628066269063 0.00792286079503654 NA NA NA hsa-miR-493-5p PPP3CA 0.229930075372342 0.731979520100109 -0.087509752034574 0.946989676888573 MirTarget -0.0980354933570249 0.0192471644522708 NA NA NA hsa-miR-501-3p PPP3CA -0.753812576327832 0.552763280802254 -0.087509752034574 0.946989676888573 MirTarget;PITA;miRNATAP -0.0724580818216709 0.0215267873565287 NA NA NA hsa-miR-502-3p PPP3CA -0.481234445251923 0.514301076452422 -0.087509752034574 0.946989676888573 MirTarget;PITA;miRNATAP -0.099843358562401 0.00694745808161356 NA NA NA hsa-miR-93-3p PPP3CA -0.438355548962673 0.549902689385444 -0.087509752034574 0.946989676888573 miRNATAP -0.0889377079193043 0.006823424004317 NA NA NA hsa-miR-93-5p PPP3CA -0.611073677204699 0.825297877093193 -0.087509752034574 0.946989676888573 miRNATAP -0.0754126478855554 0.0413684309711505 NA NA NA hsa-miR-940 PPP3CA -0.225788347550697 0.680055767105815 -0.087509752034574 0.946989676888573 miRNATAP -0.084699532769624 0.000451311017349659 NA NA NA hsa-miR-20a-3p PPP3CB 0.456808229166028 0.57674056136504 0.124829671662728 0.918408096293941 miRNATAP -0.0608699483158871 0.000608151803080226 NA NA NA hsa-miR-30d-5p PPP3CB -0.168211838771867 0.95173197030375 0.124829671662728 0.918408096293941 miRNATAP -0.0892133234635856 0.00589858311816607 NA NA NA hsa-miR-326 PPP3CB -0.567362118421427 0.620696901956282 0.124829671662728 0.918408096293941 MirTarget;PITA;miRanda -0.0760584408228153 0.00405356587168412 NA NA NA hsa-miR-339-5p PPP3CB -0.300425087100667 0.712912847076788 0.124829671662728 0.918408096293941 miRanda -0.0601929807036998 0.00401309389540193 NA NA NA hsa-miR-361-5p PPP3CB -0.138735309928775 0.941495130308343 0.124829671662728 0.918408096293941 miRanda -0.192230575391786 6.63676765547426e-06 NA NA NA hsa-miR-421 PPP3CB -0.182032017078616 0.734704500318599 0.124829671662728 0.918408096293941 miRanda -0.101890409493066 2.52334802788457e-05 NA NA NA hsa-miR-429 PPP3CB -0.456485631615963 0.806240953400535 0.124829671662728 0.918408096293941 miRanda -0.064277507908379 0.00141605780963457 NA NA NA hsa-miR-452-5p PPP3CB -0.0504626418153507 0.973874641360401 0.124829671662728 0.918408096293941 MirTarget;miRNATAP -0.0843191947282252 0.00056882694576565 NA NA NA hsa-miR-501-5p PPP3CB -0.834032628506285 0.0582725160418523 0.124829671662728 0.918408096293941 PITA;miRNATAP -0.0802006429657317 1.9126460213132e-05 NA NA NA hsa-miR-590-3p PPP3CB -0.279244755376859 0.59126669933662 0.124829671662728 0.918408096293941 miRanda -0.0508843113196877 0.0172745245525303 NA NA NA hsa-miR-375 PPP3CC -0.690952835064582 0.831716365337668 -0.156394846840244 0.838706340015868 miRanda -0.115145516987059 0.000311412501063658 NA NA NA hsa-miR-500a-3p PPP3CC -0.633375813338735 0.732582832733155 -0.156394846840244 0.838706340015868 MirTarget;miRNATAP -0.139392380696939 0.00623176129399307 NA NA NA hsa-miR-501-3p PPP3CC -0.753812576327832 0.552763280802254 -0.156394846840244 0.838706340015868 MirTarget;PITA;miRNATAP -0.0929503637558983 0.0486850104731991 NA NA NA hsa-miR-502-3p PPP3CC -0.481234445251923 0.514301076452422 -0.156394846840244 0.838706340015868 MirTarget;PITA;miRNATAP -0.136603401947088 0.0135239923652009 NA NA NA hsa-miR-101-3p PPP3R1 0.0107754887734437 0.997036362636866 -0.0496199114529308 0.972488514207793 miRNATAP -0.0844879232088999 0.0061151332280861 NA NA NA hsa-miR-1271-5p PPP3R1 -0.464440824492835 0.095633275297856 -0.0496199114529308 0.972488514207793 MirTarget -0.0594883291095973 0.00204557914883487 NA NA NA hsa-miR-139-5p PPP3R1 -0.0810891026597322 0.928690377743652 -0.0496199114529308 0.972488514207793 miRanda -0.0506070478427421 0.0173237453865823 NA NA NA hsa-miR-143-5p PPP3R1 0.10589969923845 0.933358732923556 -0.0496199114529308 0.972488514207793 miRNATAP -0.101757134766809 6.67106697655597e-08 NA NA NA hsa-miR-181a-5p PPP3R1 0.0295101956318291 0.989325168350125 -0.0496199114529308 0.972488514207793 MirTarget;miRNATAP -0.085244725584981 0.000604782781217418 NA NA NA hsa-miR-181c-5p PPP3R1 0.042951891660695 0.969159991881861 -0.0496199114529308 0.972488514207793 MirTarget;miRNATAP -0.0679681861384643 0.00156020596398249 NA NA NA hsa-miR-217 PPP3R1 0.341080669095094 0.760998144794468 -0.0496199114529308 0.972488514207793 miRanda -0.0605109323053208 7.38713228886935e-05 NA NA NA hsa-miR-27b-3p PPP3R1 -0.14277121795778 0.951937409841932 -0.0496199114529308 0.972488514207793 miRNATAP -0.108860558741904 0.00403865953676784 NA NA NA hsa-miR-30a-5p PPP3R1 0.219472325612346 0.933954023293816 -0.0496199114529308 0.972488514207793 miRNAWalker2_validate;MirTarget;miRNATAP -0.0660059608213602 0.0363890097995354 NA NA NA hsa-miR-30e-5p PPP3R1 -0.0657075181381011 0.979684509181941 -0.0496199114529308 0.972488514207793 MirTarget -0.063360109623987 0.0493181244581828 NA NA NA hsa-miR-485-3p PPP3R1 -0.078248073031686 0.840126362133974 -0.0496199114529308 0.972488514207793 MirTarget;PITA;miRNATAP -0.0673997175959238 0.000155518532244114 NA NA NA hsa-miR-708-3p PPP3R1 0.137785606206693 0.896980471394499 -0.0496199114529308 0.972488514207793 mirMAP -0.0750436749622439 9.4474117693626e-05 NA NA NA hsa-miR-146b-5p PRKACA -0.402662509440887 0.837510937985091 0.0914992374952517 0.947552027156867 PITA -0.0560860357346778 0.0263331058756169 NA NA NA hsa-miR-15a-5p PRKACA -0.0674049094129128 0.964835434214123 0.0914992374952517 0.947552027156867 miRNATAP -0.0529707889538773 0.0477981498606454 NA NA NA hsa-miR-185-3p PRKACA 0.100697585937245 0.856913315942984 0.0914992374952517 0.947552027156867 MirTarget -0.0613661929712974 0.0069001599189242 NA NA NA hsa-miR-548o-3p PRKACA -0.191447572716994 0.517725546183501 0.0914992374952517 0.947552027156867 MirTarget -0.0572781923716654 0.00457177406766713 NA NA NA hsa-miR-744-5p PRKACA -0.53616420856114 0.593323569743084 0.0914992374952517 0.947552027156867 miRNAWalker2_validate -0.0543494148700004 0.0324432100529447 NA NA NA hsa-miR-939-5p PRKACA -0.311196961912953 0.304447903545905 0.0914992374952517 0.947552027156867 MirTarget -0.0579738391651268 0.00283315800700861 NA NA NA hsa-miR-126-5p PRKACB 0.0815213541035824 0.956637332055185 0.143826955266481 0.908097519021419 mirMAP -0.368751851213397 0.00120348231579359 NA NA NA hsa-miR-141-3p PRKACB -0.31994058840327 0.87774106909065 0.143826955266481 0.908097519021419 MirTarget;TargetScan;miRNATAP -0.157820753550139 0.0370289083289272 NA NA NA hsa-miR-146b-5p PRKACB -0.402662509440887 0.837510937985091 0.143826955266481 0.908097519021419 miRanda -0.384839282045274 0.000123624033577825 NA NA NA hsa-miR-16-2-3p PRKACB -0.36717860153421 0.546850726070016 0.143826955266481 0.908097519021419 mirMAP -0.327254668787011 5.02396526650647e-05 NA NA NA hsa-miR-17-5p PRKACB -0.175448849583061 0.934544015912731 0.143826955266481 0.908097519021419 TargetScan -0.196442682711492 0.0116051317280694 NA NA NA hsa-miR-18a-5p PRKACB -0.498318455303917 0.61264091975585 0.143826955266481 0.908097519021419 miRNATAP -0.245987058818593 0.000136929122339416 NA NA NA hsa-miR-18b-5p PRKACB -0.0473300652227538 0.899981261531446 0.143826955266481 0.908097519021419 miRNATAP -0.219595347623136 0.000526621294339559 NA NA NA hsa-miR-19a-3p PRKACB -0.206793507801887 0.844637784802316 0.143826955266481 0.908097519021419 MirTarget;miRNATAP -0.207051001728292 0.00506627328237604 NA NA NA hsa-miR-19b-3p PRKACB -0.0268530183621474 0.986656783046572 0.143826955266481 0.908097519021419 miRNAWalker2_validate;MirTarget;miRNATAP -0.187582558357789 0.0344527567559653 NA NA NA hsa-miR-32-3p PRKACB -0.568003960723004 0.13133163420273 0.143826955266481 0.908097519021419 mirMAP;miRNATAP -0.203540155235648 0.00148647674126439 NA NA NA hsa-miR-323a-3p PRKACB 0.279126405514894 0.478782330851768 0.143826955266481 0.908097519021419 mirMAP -0.178413271804869 0.0194885993895622 NA NA NA hsa-miR-577 PRKACB -1.06238199218774 0.326056761787754 0.143826955266481 0.908097519021419 PITA -0.156719343600752 0.000649809465517546 NA NA NA hsa-miR-582-5p PRKACB -0.399450205475138 0.581227478860085 0.143826955266481 0.908097519021419 MirTarget;PITA;miRNATAP -0.435642871850008 4.26493780643228e-06 NA NA NA hsa-miR-590-3p PRKACB -0.279244755376859 0.59126669933662 0.143826955266481 0.908097519021419 MirTarget;PITA;miRanda;miRNATAP -0.287824756359109 8.97202997356946e-05 NA NA NA hsa-miR-590-5p PRKACB -0.547819833829572 0.472735645776647 0.143826955266481 0.908097519021419 miRanda -0.269757804036837 0.000543621862271192 NA NA NA hsa-miR-7-1-3p PRKACB -0.462485777435991 0.665899751398166 0.143826955266481 0.908097519021419 mirMAP -0.347600791347028 5.3123112509601e-05 NA NA NA hsa-miR-1296-5p PRKAR1A -0.639266760267726 0.236989089559211 0.00609526627430945 0.997181041723674 miRNAWalker2_validate -0.0898574011605761 0.00156603567784541 NA NA NA hsa-miR-141-3p PRKAR1A -0.31994058840327 0.87774106909065 0.00609526627430945 0.997181041723674 TargetScan -0.111566385407566 1.13475156521372e-05 NA NA NA hsa-miR-16-2-3p PRKAR1A -0.36717860153421 0.546850726070016 0.00609526627430945 0.997181041723674 mirMAP -0.0787383997233365 0.00467182937746418 NA NA NA hsa-miR-16-5p PRKAR1A 0.0135949734723564 0.994476223855607 0.00609526627430945 0.997181041723674 miRNAWalker2_validate -0.082946481961415 0.0155245286283497 NA NA NA hsa-miR-186-5p PRKAR1A -0.318786974828757 0.85412722938961 0.00609526627430945 0.997181041723674 mirMAP -0.138960379056428 0.00106445683378931 NA NA NA hsa-miR-192-5p PRKAR1A -0.117345487848223 0.972927287653137 0.00609526627430945 0.997181041723674 miRNAWalker2_validate -0.131803218144219 1.70399939775818e-08 NA NA NA hsa-miR-200b-3p PRKAR1A -0.426401948379212 0.863957108574195 0.00609526627430945 0.997181041723674 TargetScan -0.0906352838812349 0.00216033151432929 NA NA NA hsa-miR-215-5p PRKAR1A -0.142648109361913 0.94480931294964 0.00609526627430945 0.997181041723674 miRNAWalker2_validate -0.0509037344719145 0.000856475437026173 NA NA NA hsa-miR-25-3p PRKAR1A -0.457540448732733 0.878574066837636 0.00609526627430945 0.997181041723674 miRNAWalker2_validate -0.155774990597685 0.000238887566163613 NA NA NA hsa-miR-30b-5p PRKAR1A -0.0121430518253582 0.994622896704513 0.00609526627430945 0.997181041723674 mirMAP -0.112381249090017 0.000145079830949191 NA NA NA hsa-miR-30c-5p PRKAR1A -0.298383882401475 0.865809030482001 0.00609526627430945 0.997181041723674 mirMAP -0.148458841630206 0.000480668595228994 NA NA NA hsa-miR-30e-5p PRKAR1A -0.0657075181381011 0.979684509181941 0.00609526627430945 0.997181041723674 mirMAP -0.144338082514963 0.00222023007638473 NA NA NA hsa-miR-32-3p PRKAR1A -0.568003960723004 0.13133163420273 0.00609526627430945 0.997181041723674 mirMAP -0.0682625640347952 0.00181835275977356 NA NA NA hsa-miR-324-3p PRKAR1A -0.424387380347173 0.661528309116338 0.00609526627430945 0.997181041723674 miRNAWalker2_validate -0.0941748289789786 0.011078456634203 NA NA NA hsa-miR-381-3p PRKAR1A 0.0562600264188893 0.966895219811624 0.00609526627430945 0.997181041723674 mirMAP -0.106949176378199 0.0140644178087704 NA NA NA hsa-miR-429 PRKAR1A -0.456485631615963 0.806240953400535 0.00609526627430945 0.997181041723674 PITA;miRanda;miRNATAP -0.112635018707528 1.77370772834144e-06 NA NA NA hsa-miR-539-5p PRKAR1A 0.124342970087029 0.801067485473643 0.00609526627430945 0.997181041723674 mirMAP;miRNATAP -0.0655888769004344 0.0499841941664882 NA NA NA hsa-miR-577 PRKAR1A -1.06238199218774 0.326056761787754 0.00609526627430945 0.997181041723674 PITA;mirMAP -0.0519116033876875 0.000952660414554373 NA NA NA hsa-miR-582-5p PRKAR1A -0.399450205475138 0.581227478860085 0.00609526627430945 0.997181041723674 PITA -0.0888946659062011 0.00684669318221153 NA NA NA hsa-miR-590-3p PRKAR1A -0.279244755376859 0.59126669933662 0.00609526627430945 0.997181041723674 miRanda;mirMAP -0.0898729834763979 0.000356825387893603 NA NA NA hsa-miR-590-5p PRKAR1A -0.547819833829572 0.472735645776647 0.00609526627430945 0.997181041723674 miRanda -0.144344848438657 3.15475815244105e-08 NA NA NA hsa-miR-96-5p PRKAR1A 0.0854810872029343 0.923087820185031 0.00609526627430945 0.997181041723674 miRNAWalker2_validate;TargetScan;miRNATAP -0.107845623125508 2.75117721818048e-05 NA NA NA hsa-miR-92b-3p PRKAR1B -0.569866984318692 0.689321861489779 0.0318450328183282 0.977136177336556 miRNATAP -0.161354834160575 0.000403900793748172 NA NA NA hsa-let-7a-3p PRKAR2A -0.215598045625677 0.85543299203799 -0.400359254658287 0.684081395451204 mirMAP -0.145915448238501 0.0139295907063592 NA NA NA hsa-miR-10a-3p PRKAR2A -0.0996469316906681 0.882902638592481 -0.400359254658287 0.684081395451204 mirMAP -0.105474325556169 0.013856480398097 NA NA NA hsa-miR-140-5p PRKAR2A -0.229213026275906 0.847330111738616 -0.400359254658287 0.684081395451204 miRanda -0.262253655591601 0.000785119044577268 NA NA NA hsa-miR-142-5p PRKAR2A -0.118920788314118 0.929665277963083 -0.400359254658287 0.684081395451204 mirMAP -0.131302359195398 0.00643039296671213 NA NA NA hsa-miR-16-5p PRKAR2A 0.0135949734723564 0.994476223855607 -0.400359254658287 0.684081395451204 miRNAWalker2_validate -0.161229698537964 0.00754804821283647 NA NA NA hsa-miR-193b-5p PRKAR2A 0.195213361679028 0.606472969208971 -0.400359254658287 0.684081395451204 mirMAP -0.116355302748498 0.0201135001847084 NA NA NA hsa-miR-26a-5p PRKAR2A 0.00698202897993028 0.997719986197021 -0.400359254658287 0.684081395451204 mirMAP -0.207485959884376 0.04682090222417 NA NA NA hsa-miR-26b-5p PRKAR2A -0.0245931278499594 0.990377966314923 -0.400359254658287 0.684081395451204 mirMAP -0.243606301117074 0.000622312559360522 NA NA NA hsa-miR-32-5p PRKAR2A -0.05993267619119 0.952975951594959 -0.400359254658287 0.684081395451204 mirMAP -0.132127951981857 0.0116141043330556 NA NA NA hsa-miR-320b PRKAR2A -0.23561798088153 0.859222532827992 -0.400359254658287 0.684081395451204 mirMAP -0.141317120899187 0.0137262405686247 NA NA NA hsa-miR-335-5p PRKAR2A -0.0284895175847679 0.973380867832231 -0.400359254658287 0.684081395451204 mirMAP -0.108283561274697 0.0275980322124908 NA NA NA hsa-miR-377-3p PRKAR2A -0.0435868040110954 0.893514136702459 -0.400359254658287 0.684081395451204 mirMAP -0.138724729417275 0.0032774854170653 NA NA NA hsa-miR-582-5p PRKAR2A -0.399450205475138 0.581227478860085 -0.400359254658287 0.684081395451204 miRNATAP -0.116608016988351 0.0450386436272616 NA NA NA hsa-miR-590-5p PRKAR2A -0.547819833829572 0.472735645776647 -0.400359254658287 0.684081395451204 mirMAP -0.106859770724137 0.0240077481634145 NA NA NA hsa-miR-654-3p PRKAR2A 0.0699248385448739 0.946997748280675 -0.400359254658287 0.684081395451204 PITA -0.128900512429024 0.0294685967239687 NA NA NA hsa-miR-92b-3p PRKAR2A -0.569866984318692 0.689321861489779 -0.400359254658287 0.684081395451204 mirMAP -0.150628105250479 0.00333148415222561 NA NA NA hsa-let-7a-3p PRKAR2B -0.215598045625677 0.85543299203799 -0.108203352456923 0.864208239994479 mirMAP -0.321301677507322 0.00677085783389006 NA NA NA hsa-let-7f-1-3p PRKAR2B -0.31101436822914 0.693407210545374 -0.108203352456923 0.864208239994479 mirMAP -0.534962041770848 0.000913984496763097 NA NA NA hsa-miR-186-5p PRKAR2B -0.318786974828757 0.85412722938961 -0.108203352456923 0.864208239994479 mirMAP -0.502782469096194 0.000791078328150689 NA NA NA hsa-miR-200b-3p PRKAR2B -0.426401948379212 0.863957108574195 -0.108203352456923 0.864208239994479 TargetScan -0.438478599626453 2.19850692584662e-05 NA NA NA hsa-miR-200c-3p PRKAR2B -0.437282635857873 0.887118598436407 -0.108203352456923 0.864208239994479 miRNATAP -0.457503221137187 1.66816486062485e-05 NA NA NA hsa-miR-32-5p PRKAR2B -0.05993267619119 0.952975951594959 -0.108203352456923 0.864208239994479 miRNATAP -0.489592612964453 1.9710313510613e-06 NA NA NA hsa-miR-335-3p PRKAR2B -0.244830745789445 0.88450019116631 -0.108203352456923 0.864208239994479 mirMAP -0.662453520071633 1.1362940635392e-12 NA NA NA hsa-miR-361-5p PRKAR2B -0.138735309928775 0.941495130308343 -0.108203352456923 0.864208239994479 miRanda -0.882164157140769 7.23663062288783e-07 NA NA NA hsa-miR-362-3p PRKAR2B -0.721040238345347 0.0345881362485733 -0.108203352456923 0.864208239994479 miRanda -0.382045203466261 8.77748662261711e-06 NA NA NA hsa-miR-429 PRKAR2B -0.456485631615963 0.806240953400535 -0.108203352456923 0.864208239994479 PITA;miRanda;miRNATAP -0.40684001346636 9.90307216676999e-07 NA NA NA hsa-miR-452-5p PRKAR2B -0.0504626418153507 0.973874641360401 -0.108203352456923 0.864208239994479 miRNATAP -0.354765023961755 0.000542795811909376 NA NA NA hsa-miR-590-3p PRKAR2B -0.279244755376859 0.59126669933662 -0.108203352456923 0.864208239994479 miRNAWalker2_validate;miRanda -0.364663794042552 3.74985761919246e-05 NA NA NA hsa-miR-92a-3p PRKAR2B 0.0278830870766349 0.993247426671713 -0.108203352456923 0.864208239994479 miRNATAP -0.706146585820868 2.44308347035194e-11 NA NA NA hsa-miR-127-3p RIPK1 0.0756694410683956 0.972625730635758 -0.0499201995221403 0.968495079650267 miRanda -0.0774993924762195 0.0201098632559904 NA NA NA hsa-miR-374a-3p RIPK1 -0.118320910531011 0.958176637009264 -0.0499201995221403 0.968495079650267 mirMAP -0.0653286229360815 0.0158036125400817 NA NA NA hsa-miR-421 RIPK1 -0.182032017078616 0.734704500318599 -0.0499201995221403 0.968495079650267 miRanda;mirMAP -0.0779116498442659 0.00255198541428278 NA NA NA hsa-miR-19a-3p TNF -0.206793507801887 0.844637784802316 -0.242556492684374 0.505877742425651 miRTarBase -0.172263396107975 0.0261680668402111 26302825 Hsa miR 19a is associated with lymph metastasis and mediates the TNF α induced epithelial to mesenchymal transition in colorectal cancer metastasis colorectal cancer hsa-miR-203a-3p TNF -0.265248086637561 0.931593594361942 -0.242556492684374 0.505877742425651 miRTarBase -0.15152411901001 0.0288969016464917 NA NA NA hsa-miR-320b TNF -0.23561798088153 0.859222532827992 -0.242556492684374 0.505877742425651 miRanda -0.202539141250571 0.0422878243755715 NA NA NA hsa-miR-339-5p TNF -0.300425087100667 0.712912847076788 -0.242556492684374 0.505877742425651 miRanda -0.240752524581911 0.00150463927692232 NA NA NA hsa-miR-361-5p TNF -0.138735309928775 0.941495130308343 -0.242556492684374 0.505877742425651 miRanda -0.370762940718088 0.0186799793636795 NA NA NA hsa-miR-429 TNF -0.456485631615963 0.806240953400535 -0.242556492684374 0.505877742425651 miRNATAP -0.201076512972768 0.00615440839426584 NA NA NA hsa-miR-577 TNF -1.06238199218774 0.326056761787754 -0.242556492684374 0.505877742425651 miRNATAP -0.134551715326189 0.00528975118205988 NA NA NA hsa-miR-145-5p TNFRSF10A 0.0379358609701441 0.987582252034037 -0.54278943733723 0.50241305397941 MirTarget -0.118334513922428 0.020123727634043 NA NA NA hsa-miR-133b TNFRSF10B 0.392161188688359 0.560763234081075 -0.383201678231656 0.799628854665791 miRanda;miRNATAP -0.0600698470354553 0.0225921696828324 NA NA NA hsa-miR-26a-5p TNFRSF10B 0.00698202897993028 0.997719986197021 -0.383201678231656 0.799628854665791 mirMAP -0.241890988316379 0.0187660252860246 NA NA NA hsa-miR-30a-5p TNFRSF10B 0.219472325612346 0.933954023293816 -0.383201678231656 0.799628854665791 miRNAWalker2_validate -0.290874641193986 0.000283561036834234 NA NA NA hsa-miR-30c-2-3p TNFRSF10B 0.242912714924037 0.746927269997556 -0.383201678231656 0.799628854665791 MirTarget -0.162344152230231 0.0128335238143222 NA NA NA hsa-miR-199b-5p TNFRSF10D -0.0396557270992508 0.977172718873203 -0.141542495826742 0.872377920782891 miRanda -0.224317948876358 0.00104992803157878 NA NA NA hsa-miR-26a-5p TNFRSF10D 0.00698202897993028 0.997719986197021 -0.141542495826742 0.872377920782891 mirMAP -0.415065974648953 0.00259807529206913 NA NA NA hsa-miR-30a-3p TNFRSF10D 0.250338313897394 0.917094926793447 -0.141542495826742 0.872377920782891 miRNAWalker2_validate -0.226835891342346 0.0178829401771766 NA NA NA hsa-miR-98-5p TNFSF10 -0.168162186023221 0.898802461503524 -0.27351623447675 0.846347198734811 miRNAWalker2_validate -0.161749402252697 0.00700741596734545 NA NA NA hsa-let-7e-5p XIAP 0.211156073215582 0.922335699862928 0.000689557720739309 0.999627321412725 miRNAWalker2_validate -0.104939478471105 0.0255049216303967 NA NA NA hsa-miR-142-5p XIAP -0.118920788314118 0.929665277963083 0.000689557720739309 0.999627321412725 mirMAP;miRNATAP -0.077531022252884 0.00578671703015698 NA NA NA hsa-miR-146a-5p XIAP -0.581292803346906 0.73685134936757 0.000689557720739309 0.999627321412725 mirMAP -0.0598413491583598 0.0233602753222534 NA NA NA hsa-miR-146b-5p XIAP -0.402662509440887 0.837510937985091 0.000689557720739309 0.999627321412725 mirMAP;miRNATAP -0.101204227996522 0.00433301524867694 NA NA NA hsa-miR-155-5p XIAP -0.407235807706004 0.828669616718496 0.000689557720739309 0.999627321412725 MirTarget -0.0706528163869639 0.0219261880274407 26779627 Bioinformatic predictions the dual-luciferase reporter assay and western blot analysis were used to detect how miR-155 regulates X-linked inhibitor of apoptosis protein XIAP; Furthermore the results from the luciferase assays and western blot analysis identified XIAP as the direct target of miR-155; In addition introducing XIAP cDNA without a three prime untranslated region 3'-UTR rescued the miR-155 promotion of apoptosis; These results indicate that miR-155 mediates cisplatin-induced apoptosis by targeting XIAP in ovarian cancer cells and that miR-155 could be a potential therapeutic target to increase the efficiency of ovarian cancer interventions ovarian cancer hsa-miR-330-3p XIAP 0.00298687748748416 0.994504006750491 0.000689557720739309 0.999627321412725 mirMAP;miRNATAP -0.0867762892069073 0.0111425822939361 NA NA NA hsa-miR-340-5p XIAP -0.00276909425328853 0.99757361161055 0.000689557720739309 0.999627321412725 mirMAP;miRNATAP -0.0902850409186863 0.0136462081792187 NA NA NA hsa-miR-92b-3p XIAP -0.569866984318692 0.689321861489779 0.000689557720739309 0.999627321412725 mirMAP -0.0852435641389304 0.00441629850142373 NA NA NA