miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-107 ACVR1 0.678998026350662 2.56224148930538e-16 -0.462938675109919 4.22826789612895e-13 miRanda -0.341475890592561 4.28612624303003e-42 NA NA NA hsa-miR-130b-3p ACVR1 1.38122163823846 1.00932179737836e-26 -0.462938675109919 4.22826789612895e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.105651536077817 1.89488126222222e-10 NA NA NA hsa-miR-148b-3p ACVR1 1.0552576751879 1.6679285705231e-29 -0.462938675109919 4.22826789612895e-13 MirTarget -0.102171018697993 8.03726381461303e-06 NA NA NA hsa-miR-19b-3p ACVR1 0.139124391010031 0.255658553872934 -0.462938675109919 4.22826789612895e-13 miRNAWalker2_validate -0.120473239964941 1.98354210807315e-11 NA NA NA hsa-miR-30b-5p ACVR1 -0.46540603860146 2.4709940429591e-05 -0.462938675109919 4.22826789612895e-13 MirTarget -0.110759549818898 2.72868569695075e-08 NA NA NA hsa-miR-30d-5p ACVR1 -0.247082219011045 0.00406717930063148 -0.462938675109919 4.22826789612895e-13 MirTarget;miRNATAP -0.206470425752546 5.29481819061924e-16 NA NA NA hsa-miR-30e-5p ACVR1 0.293491764699475 0.000372291967271834 -0.462938675109919 4.22826789612895e-13 MirTarget -0.117512420167977 1.27216347278214e-05 NA NA NA hsa-miR-330-3p ACVR1 0.432728362037032 0.00041335506960812 -0.462938675109919 4.22826789612895e-13 MirTarget;PITA -0.106644073620098 4.49931005626429e-09 NA NA NA hsa-miR-429 ACVR1 2.84108892259147 3.88520896426515e-64 -0.462938675109919 4.22826789612895e-13 miRNATAP -0.119553302184784 1.14526847802397e-23 NA NA NA hsa-miR-590-3p ACVR1 1.27438512890514 1.03164723481469e-23 -0.462938675109919 4.22826789612895e-13 miRanda -0.108463868098368 7.42380935689782e-10 NA NA NA hsa-miR-96-5p ACVR1 3.24596558166606 1.92296159041707e-98 -0.462938675109919 4.22826789612895e-13 TargetScan;miRNATAP -0.100604313502428 1.25599818730201e-15 NA NA NA hsa-let-7d-5p ACVR1C 0.410958462607207 6.07808182756787e-06 -5.20071129736289 8.81931099882978e-104 MirTarget;miRNATAP -0.382116715205794 0.00021701935831798 NA NA NA hsa-let-7e-5p ACVR1C 0.261471269338985 0.00191077095550257 -5.20071129736289 8.81931099882978e-104 MirTarget;miRNATAP -0.391129535622582 0.000478036013006995 NA NA NA hsa-miR-181a-5p ACVR1C 0.635863607630183 6.72486918157744e-11 -5.20071129736289 8.81931099882978e-104 miRNATAP -0.620562379709194 5.89125073509107e-11 NA NA NA hsa-miR-181b-5p ACVR1C 1.22749257795094 1.21998198830919e-27 -5.20071129736289 8.81931099882978e-104 miRNATAP -0.736387159640416 1.1522673578888e-20 NA NA NA hsa-miR-181c-5p ACVR1C 0.574847839298605 4.51287502066478e-07 -5.20071129736289 8.81931099882978e-104 miRNATAP -0.582612994724267 6.82133958480936e-13 NA NA NA hsa-miR-200b-3p ACVR1C 2.11744072703209 1.66710572104191e-43 -5.20071129736289 8.81931099882978e-104 TargetScan -0.692003711219126 2.03439748086501e-35 NA NA NA hsa-miR-330-3p ACVR1C 0.432728362037032 0.00041335506960812 -5.20071129736289 8.81931099882978e-104 MirTarget -0.237793048547375 0.00219426575105842 NA NA NA hsa-miR-331-5p ACVR1C 0.682437632502949 4.10871642662371e-11 -5.20071129736289 8.81931099882978e-104 miRNATAP -0.604316750970958 1.40966126146655e-11 NA NA NA hsa-miR-429 ACVR1C 2.84108892259147 3.88520896426515e-64 -5.20071129736289 8.81931099882978e-104 PITA;miRanda;miRNATAP -0.697810047692677 7.01989078734797e-46 NA NA NA hsa-miR-590-3p ACVR1C 1.27438512890514 1.03164723481469e-23 -5.20071129736289 8.81931099882978e-104 miRanda -0.580497974664095 4.97336103597514e-15 NA NA NA hsa-miR-590-5p ACVR1C 0.746515607868274 8.51300479640125e-09 -5.20071129736289 8.81931099882978e-104 PITA;miRanda -0.445957185891423 4.05699479656914e-10 NA NA NA hsa-miR-7-1-3p ACVR1C 0.686579567507582 1.20731554448806e-07 -5.20071129736289 8.81931099882978e-104 mirMAP -0.279361124975965 0.000101129261147657 NA NA NA hsa-miR-98-5p ACVR1C 0.656336869298973 9.03113188590466e-15 -5.20071129736289 8.81931099882978e-104 MirTarget -0.793231535265132 2.56641262477936e-13 NA NA NA hsa-let-7e-5p ACVR2A 0.261471269338985 0.00191077095550257 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.110838593636447 0.000569208718270341 NA NA NA hsa-miR-128-3p ACVR2A 0.90296715955238 9.925204823863e-23 -0.964184609321378 1.30052843588401e-37 MirTarget -0.217582421784768 1.37517380343148e-14 NA NA NA hsa-miR-130b-3p ACVR2A 1.38122163823846 1.00932179737836e-26 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.128088696638873 2.25428516577612e-10 NA NA NA hsa-miR-141-3p ACVR2A 2.99777540204168 1.26370498493024e-78 -0.964184609321378 1.30052843588401e-37 TargetScan;miRNATAP -0.161379309311092 1.25725298325859e-27 NA NA NA hsa-miR-15a-5p ACVR2A 0.812445324157528 4.50263417099822e-20 -0.964184609321378 1.30052843588401e-37 MirTarget;miRNATAP -0.36516801924186 2.81837633955843e-37 NA NA NA hsa-miR-15b-5p ACVR2A 0.788659356634696 1.13678211092534e-11 -0.964184609321378 1.30052843588401e-37 MirTarget;miRNATAP -0.16858903260967 1.0459646769634e-13 NA NA NA hsa-miR-16-5p ACVR2A 0.46835991343556 1.91125356547776e-06 -0.964184609321378 1.30052843588401e-37 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.182125277687158 1.840101008093e-11 NA NA NA hsa-miR-181b-5p ACVR2A 1.22749257795094 1.21998198830919e-27 -0.964184609321378 1.30052843588401e-37 MirTarget;miRNATAP -0.115588398670053 5.65233109391086e-07 NA NA NA hsa-miR-183-5p ACVR2A 2.95681814393872 1.09965777344285e-92 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.143429776860837 1.10115003008173e-18 NA NA NA hsa-miR-185-5p ACVR2A 0.482334746589337 3.68475879959415e-09 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.307434790887798 1.14081881563322e-21 NA NA NA hsa-miR-192-5p ACVR2A 1.33366224451777 9.5116159697107e-29 -0.964184609321378 1.30052843588401e-37 miRNAWalker2_validate;miRNATAP -0.180643941948404 2.90310004281952e-17 NA NA NA hsa-miR-200a-3p ACVR2A 2.55218480823434 2.96135446816238e-51 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.142523834102645 2.08957993508987e-22 NA NA NA hsa-miR-200b-3p ACVR2A 2.11744072703209 1.66710572104191e-43 -0.964184609321378 1.30052843588401e-37 TargetScan -0.143541862814667 1.76104677420962e-18 NA NA NA hsa-miR-200c-3p ACVR2A 2.07038651806183 6.84613386286599e-51 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.155691181802949 5.31342226529533e-18 NA NA NA hsa-miR-21-5p ACVR2A 2.32007501846389 3.08394781855554e-137 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.228019435065362 1.72805692634805e-21 NA NA NA hsa-miR-29b-2-5p ACVR2A -0.263499971180298 0.0400001755611965 -0.964184609321378 1.30052843588401e-37 mirMAP -0.107651989989685 2.75376303318154e-07 NA NA NA hsa-miR-29b-3p ACVR2A 0.438847962603729 6.46722433236121e-05 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.203237419946028 3.36234269209612e-17 NA NA NA hsa-miR-29c-3p ACVR2A -0.0652732378039769 0.563774115756922 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.138823667480276 5.19803499835417e-09 NA NA NA hsa-miR-331-5p ACVR2A 0.682437632502949 4.10871642662371e-11 -0.964184609321378 1.30052843588401e-37 PITA -0.179622432713345 2.56782330912698e-12 NA NA NA hsa-miR-429 ACVR2A 2.84108892259147 3.88520896426515e-64 -0.964184609321378 1.30052843588401e-37 PITA;miRanda;miRNATAP -0.146889740348126 4.18297883812051e-24 NA NA NA hsa-miR-454-3p ACVR2A 1.28177672191095 6.84024979484587e-21 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.137225049020457 7.85807508870824e-13 NA NA NA hsa-miR-590-3p ACVR2A 1.27438512890514 1.03164723481469e-23 -0.964184609321378 1.30052843588401e-37 MirTarget;PITA;miRanda;miRNATAP -0.128362682046608 2.20895457265325e-09 NA NA NA hsa-miR-671-5p ACVR2A 1.55248047544015 7.7377784125886e-33 -0.964184609321378 1.30052843588401e-37 MirTarget;PITA;miRNATAP -0.178633008800824 2.95102208280371e-19 NA NA NA hsa-miR-96-5p ACVR2A 3.24596558166606 1.92296159041707e-98 -0.964184609321378 1.30052843588401e-37 TargetScan;miRNATAP -0.154150910111768 2.30970117244934e-24 NA NA NA hsa-miR-140-3p ACVR2B -1.25844395244141 5.29222651039892e-33 -0.109179355871245 0.196055880216932 miRNAWalker2_validate;PITA;miRNATAP -0.205812392433297 2.84498041624841e-15 NA NA NA hsa-miR-15a-5p ACVR2B 0.812445324157528 4.50263417099822e-20 -0.109179355871245 0.196055880216932 miRNATAP -0.175444464601842 3.65634075266698e-08 NA NA NA hsa-miR-374a-5p ACVR2B -0.239709888246804 0.00309819667153627 -0.109179355871245 0.196055880216932 MirTarget -0.169809922205124 2.0190940823835e-06 NA NA NA hsa-miR-374b-5p ACVR2B -0.466781429946153 1.17238311619116e-08 -0.109179355871245 0.196055880216932 MirTarget -0.119604328959342 0.000690837262808481 NA NA NA hsa-miR-455-5p ACVR2B 0.284641224662773 0.0357572339594277 -0.109179355871245 0.196055880216932 PITA -0.125395914976428 3.22447748901509e-09 NA NA NA hsa-miR-106b-5p BMP2 1.22477789913175 2.31787213143326e-32 -2.65857867772634 6.10527487782614e-50 miRNATAP -0.26660590164265 1.12724731726372e-05 NA NA NA hsa-miR-429 BMP2 2.84108892259147 3.88520896426515e-64 -2.65857867772634 6.10527487782614e-50 miRNATAP -0.40826129557167 7.17935100433753e-32 NA NA NA hsa-miR-590-3p BMP2 1.27438512890514 1.03164723481469e-23 -2.65857867772634 6.10527487782614e-50 PITA;miRanda;mirMAP -0.178033380986492 0.000666105040333196 NA NA NA hsa-miR-125a-3p BMP4 -0.176412960953959 0.10108079286419 -1.10149092310353 5.54349856867319e-09 miRanda -0.163298863788863 0.00752732533450238 NA NA NA hsa-miR-142-3p BMP4 1.53951237846104 2.06769936282034e-17 -1.10149092310353 5.54349856867319e-09 PITA;miRanda -0.225090005062372 1.21121726101325e-10 NA NA NA hsa-miR-590-3p BMP4 1.27438512890514 1.03164723481469e-23 -1.10149092310353 5.54349856867319e-09 miRanda -0.488786644087842 1.20391215808401e-21 NA NA NA hsa-miR-340-5p BMP5 1.0857159627596 4.94471062546756e-24 -4.21260848297834 3.39987684895973e-39 mirMAP -0.301115943990931 0.00419713980656556 NA NA NA hsa-miR-590-3p BMP5 1.27438512890514 1.03164723481469e-23 -4.21260848297834 3.39987684895973e-39 mirMAP -0.431944392599325 2.99721483164888e-06 NA NA NA hsa-miR-130b-3p BMP6 1.38122163823846 1.00932179737836e-26 -2.24141618102819 3.76360256327078e-50 MirTarget -0.147583952017726 0.000371484950082228 NA NA NA hsa-miR-301a-3p BMP6 1.32170168375632 2.12280368957514e-15 -2.24141618102819 3.76360256327078e-50 MirTarget -0.202490128801353 3.84192366950574e-10 NA NA NA hsa-miR-454-3p BMP6 1.28177672191095 6.84024979484587e-21 -2.24141618102819 3.76360256327078e-50 MirTarget -0.283576224076596 3.53482708336303e-13 NA NA NA hsa-miR-590-3p BMP6 1.27438512890514 1.03164723481469e-23 -2.24141618102819 3.76360256327078e-50 mirMAP -0.141427399977376 0.00131871796494223 NA NA NA hsa-let-7b-5p BMP7 -0.54215483448257 7.21347617597858e-08 -0.568347328167421 0.0198013961935752 miRNAWalker2_validate -0.258809976662431 0.0017758548082738 NA NA NA hsa-miR-30a-5p BMP7 -0.392489994825279 0.00954894667761676 -0.568347328167421 0.0198013961935752 mirMAP;miRNATAP -0.296828011310005 6.35417158979831e-08 NA NA NA hsa-miR-30c-5p BMP7 -0.393222674580066 8.06961465717306e-05 -0.568347328167421 0.0198013961935752 mirMAP;miRNATAP -0.352978199901424 2.48460436378243e-05 NA NA NA hsa-miR-338-3p BMP7 0.0799903526884966 0.575137668326679 -0.568347328167421 0.0198013961935752 miRanda -0.235089742330144 6.0197758781171e-05 NA NA NA hsa-miR-342-3p BMP7 1.21944481975657 6.81914373001202e-19 -0.568347328167421 0.0198013961935752 miRNAWalker2_validate;miRTarBase;miRanda -0.39939088547044 1.28747468011685e-11 NA NA NA hsa-miR-140-5p BMP8A -0.755971041589807 9.68060922934542e-14 2.5531168368725 9.36184416259286e-78 miRanda -0.17092515217601 0.000682416339622627 NA NA NA hsa-miR-30a-3p BMP8A -1.08956435286856 1.10750674569595e-12 2.5531168368725 9.36184416259286e-78 MirTarget -0.248477166436933 3.93577730861837e-14 NA NA NA hsa-miR-30e-3p BMP8A -0.708952170420973 1.05866470714978e-22 2.5531168368725 9.36184416259286e-78 MirTarget -0.532592839026743 1.53477893028116e-14 NA NA NA hsa-miR-423-5p BMP8A -0.0644843381453004 0.462275547464843 2.5531168368725 9.36184416259286e-78 MirTarget -0.205933948944955 0.000518526442624442 NA NA NA hsa-miR-103a-3p BMP8B 0.610673390034345 1.63113920514646e-12 0.540302731395442 0.00139550250521326 mirMAP -0.225187088163204 0.00072552447723644 NA NA NA hsa-miR-26b-5p BMP8B -0.331527896896866 0.000551258576575092 0.540302731395442 0.00139550250521326 miRNAWalker2_validate -0.157111125503936 0.00962756270933669 NA NA NA hsa-miR-34c-5p BMP8B -0.0896438810345765 0.557016551646841 0.540302731395442 0.00139550250521326 miRanda -0.143603564254755 0.000168923059126371 NA NA NA hsa-miR-362-5p BMP8B -0.248676340901797 0.0726089851456282 0.540302731395442 0.00139550250521326 mirMAP -0.155746365237471 0.0002015321545365 NA NA NA hsa-miR-423-5p BMP8B -0.0644843381453004 0.462275547464843 0.540302731395442 0.00139550250521326 MirTarget -0.153976492043689 0.0210570163676643 NA NA NA hsa-miR-340-5p BMPR1A 1.0857159627596 4.94471062546756e-24 -0.747880920024155 4.16477435098274e-20 MirTarget -0.205607556993107 7.51804306692324e-16 NA NA NA hsa-miR-589-5p BMPR1A 0.367182541239722 1.67804815542873e-05 -0.747880920024155 4.16477435098274e-20 MirTarget -0.124623957239379 0.000198491088497215 NA NA NA hsa-miR-125b-5p BMPR1B -1.94393269763542 2.78180543229264e-58 2.3325512314431 1.87054528568578e-09 miRNAWalker2_validate;miRTarBase;MirTarget -0.523279943087425 3.82265313853702e-07 19738052;21556765 A risk variant in an miR 125b binding site in BMPR1B is associated with breast cancer pathogenesis; Furthermore luciferase reporter assays and overexpression of miR-125b-mimics combined with quantitative reverse transcription-PCR showed that BMPR1B transcript is a direct target of miR-125b and that miR-125b differentially regulates the C and T alleles of rs1434536; These results suggest that allele-specific regulation of BMPR1B by miR-125b explains the observed disease risk;Our findings show that rs1434536 in the 3'UTR of BMPR1B gene affects the binding ability of miR-125b to BMPR1B mRNA and contributes to the genetic predisposition to localized prostate cancer and patients aged>70 years ; breast cancer;prostate cancer hsa-miR-130a-3p BMPR1B -1.15024914519431 6.51290317952496e-19 2.3325512314431 1.87054528568578e-09 miRNATAP -0.468510027326227 3.72612678298247e-06 NA NA NA hsa-miR-130b-3p BMPR1B 1.38122163823846 1.00932179737836e-26 2.3325512314431 1.87054528568578e-09 miRNATAP -0.330771696537828 0.00111424679509253 NA NA NA hsa-miR-140-3p BMPR1B -1.25844395244141 5.29222651039892e-33 2.3325512314431 1.87054528568578e-09 MirTarget -0.897617718710942 1.46772814243533e-13 NA NA NA hsa-miR-142-5p BMPR1B 1.16509303143593 1.96641162209073e-13 2.3325512314431 1.87054528568578e-09 mirMAP -0.444165525578716 8.90675105128216e-08 NA NA NA hsa-miR-146b-5p BMPR1B 0.631041661167954 6.20366593452965e-08 2.3325512314431 1.87054528568578e-09 miRanda -0.763779914564347 1.66236814877754e-11 NA NA NA hsa-miR-150-5p BMPR1B -0.832049526091211 3.45299201139224e-05 2.3325512314431 1.87054528568578e-09 MirTarget -0.447906956063762 1.00992000293386e-11 NA NA NA hsa-miR-205-5p BMPR1B -1.70057043266505 1.20976599540743e-09 2.3325512314431 1.87054528568578e-09 miRNATAP -0.128948367199523 0.00663542809472005 NA NA NA hsa-miR-23a-3p BMPR1B -0.217176729033818 0.00962615056202409 2.3325512314431 1.87054528568578e-09 mirMAP -0.54134602392377 0.000777327916413561 NA NA NA hsa-miR-24-3p BMPR1B -0.120123317289941 0.21432376743243 2.3325512314431 1.87054528568578e-09 miRNATAP -0.924083329815397 2.27189205259187e-11 NA NA NA hsa-miR-26a-5p BMPR1B -0.481180084102235 1.82368246174758e-10 2.3325512314431 1.87054528568578e-09 mirMAP -0.502628260270685 0.004703613816135 NA NA NA hsa-miR-374a-5p BMPR1B -0.239709888246804 0.00309819667153627 2.3325512314431 1.87054528568578e-09 MirTarget -1.34531949769775 2.36721949756409e-16 NA NA NA hsa-miR-374b-5p BMPR1B -0.466781429946153 1.17238311619116e-08 2.3325512314431 1.87054528568578e-09 MirTarget -1.21428024206699 6.08013000870106e-14 NA NA NA hsa-miR-576-5p BMPR1B 0.0649387707567879 0.588791966096287 2.3325512314431 1.87054528568578e-09 mirMAP -0.437349947086476 9.41645537856705e-05 NA NA NA hsa-miR-582-5p BMPR1B 0.201134299470983 0.149482495292227 2.3325512314431 1.87054528568578e-09 mirMAP;miRNATAP -0.25021027052656 0.0103283377253042 NA NA NA hsa-miR-590-3p BMPR1B 1.27438512890514 1.03164723481469e-23 2.3325512314431 1.87054528568578e-09 miRanda;mirMAP -0.285771807763549 0.00802490630601688 NA NA NA hsa-miR-889-3p BMPR1B -0.377352927733213 0.00501260024755438 2.3325512314431 1.87054528568578e-09 MirTarget -0.507675391479965 3.5174865160677e-07 NA NA NA hsa-miR-106b-5p BMPR2 1.22477789913175 2.31787213143326e-32 -0.619963448559116 4.34614935044474e-16 MirTarget;miRNATAP -0.276781658266959 5.38230356337068e-31 NA NA NA hsa-miR-128-3p BMPR2 0.90296715955238 9.925204823863e-23 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate -0.220456287512942 2.32429009664863e-15 NA NA NA hsa-miR-130b-3p BMPR2 1.38122163823846 1.00932179737836e-26 -0.619963448559116 4.34614935044474e-16 MirTarget;miRNATAP -0.132800742011577 2.36935481480511e-11 NA NA NA hsa-miR-148a-5p BMPR2 0.572692271754695 2.14306251522796e-06 -0.619963448559116 4.34614935044474e-16 mirMAP -0.120124264765292 3.51868525242609e-08 NA NA NA hsa-miR-17-5p BMPR2 0.599531757298529 1.07318660415906e-05 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.169916613515935 4.71819035178939e-19 NA NA NA hsa-miR-181a-5p BMPR2 0.635863607630183 6.72486918157744e-11 -0.619963448559116 4.34614935044474e-16 miRNATAP -0.224587920836486 3.17918043865356e-17 NA NA NA hsa-miR-181b-5p BMPR2 1.22749257795094 1.21998198830919e-27 -0.619963448559116 4.34614935044474e-16 miRNATAP -0.224720984868525 5.95101149780694e-24 NA NA NA hsa-miR-181c-5p BMPR2 0.574847839298605 4.51287502066478e-07 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;miRNATAP -0.153556997294714 2.48251772986161e-11 NA NA NA hsa-miR-185-5p BMPR2 0.482334746589337 3.68475879959415e-09 -0.619963448559116 4.34614935044474e-16 MirTarget -0.344917833393806 4.84718132418701e-28 NA NA NA hsa-miR-19a-3p BMPR2 0.817507952171848 3.76285090469625e-08 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.155870077480006 3.19291951165458e-19 NA NA NA hsa-miR-19b-3p BMPR2 0.139124391010031 0.255658553872934 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.135077875250079 3.91490815909773e-10 NA NA NA hsa-miR-200b-3p BMPR2 2.11744072703209 1.66710572104191e-43 -0.619963448559116 4.34614935044474e-16 mirMAP -0.121047661495268 8.73119456445721e-14 NA NA NA hsa-miR-200c-3p BMPR2 2.07038651806183 6.84613386286599e-51 -0.619963448559116 4.34614935044474e-16 mirMAP -0.13697648800764 1.55247615315968e-14 NA NA NA hsa-miR-20a-5p BMPR2 0.44979911120222 0.000602386964327228 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.249993991973903 3.35999987947366e-38 NA NA NA hsa-miR-21-5p BMPR2 2.32007501846389 3.08394781855554e-137 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;miRTarBase;MirTarget -0.217097837256464 4.31156278024056e-20 NA NA NA hsa-miR-25-3p BMPR2 -0.00546790775985073 0.944061771389468 -0.619963448559116 4.34614935044474e-16 miRNATAP -0.22770448332314 2.41816718314955e-11 NA NA NA hsa-miR-32-5p BMPR2 1.38676603945192 2.29428299685976e-34 -0.619963448559116 4.34614935044474e-16 miRNATAP -0.174672112420236 3.33558378279438e-15 NA NA NA hsa-miR-340-5p BMPR2 1.0857159627596 4.94471062546756e-24 -0.619963448559116 4.34614935044474e-16 mirMAP -0.227147675302332 5.38594766443045e-22 NA NA NA hsa-miR-361-5p BMPR2 -0.0996867547900457 0.095428250126326 -0.619963448559116 4.34614935044474e-16 MirTarget;miRanda;mirMAP;miRNATAP -0.334517180577302 6.53819650110874e-14 NA NA NA hsa-miR-374a-3p BMPR2 0.34122393953022 2.28714105382856e-05 -0.619963448559116 4.34614935044474e-16 MirTarget;miRNATAP -0.118088688320067 0.000357901047098203 NA NA NA hsa-miR-429 BMPR2 2.84108892259147 3.88520896426515e-64 -0.619963448559116 4.34614935044474e-16 mirMAP;miRNATAP -0.12305207734683 1.41517075947211e-17 NA NA NA hsa-miR-455-5p BMPR2 0.284641224662773 0.0357572339594277 -0.619963448559116 4.34614935044474e-16 PITA -0.150702454713517 6.6886302737598e-15 NA NA NA hsa-miR-532-5p BMPR2 0.0386976222860582 0.682018574136515 -0.619963448559116 4.34614935044474e-16 PITA -0.19453245376842 3.69016564906427e-12 NA NA NA hsa-miR-590-3p BMPR2 1.27438512890514 1.03164723481469e-23 -0.619963448559116 4.34614935044474e-16 MirTarget;miRanda;mirMAP;miRNATAP -0.132760837851511 3.2984433329505e-10 NA NA NA hsa-miR-671-5p BMPR2 1.55248047544015 7.7377784125886e-33 -0.619963448559116 4.34614935044474e-16 miRNATAP -0.189454100614002 3.2885754867585e-22 NA NA NA hsa-miR-769-5p BMPR2 0.564871766265874 8.16695101656941e-10 -0.619963448559116 4.34614935044474e-16 miRNATAP -0.105758705299915 0.000232905961375314 NA NA NA hsa-miR-92a-3p BMPR2 -0.342420481092807 0.000732275969501111 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;miRNATAP -0.157420472890194 1.52521487852708e-09 NA NA NA hsa-miR-93-5p BMPR2 1.01788600209314 1.24312921618126e-21 -0.619963448559116 4.34614935044474e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.297498916175773 3.22742453305909e-37 NA NA NA hsa-miR-429 CDKN2B 2.84108892259147 3.88520896426515e-64 -0.535762100005625 6.04515808229722e-05 miRanda -0.161930481171186 1.19377952611012e-10 NA NA NA hsa-miR-450b-5p CDKN2B 0.781564228875267 3.90462514315383e-11 -0.535762100005625 6.04515808229722e-05 mirMAP -0.154969260267371 5.41198999368989e-05 NA NA NA hsa-miR-671-5p CDKN2B 1.55248047544015 7.7377784125886e-33 -0.535762100005625 6.04515808229722e-05 PITA -0.154028875207593 8.10893805948914e-06 NA NA NA hsa-miR-98-5p CDKN2B 0.656336869298973 9.03113188590466e-15 -0.535762100005625 6.04515808229722e-05 miRNAWalker2_validate -0.143107086249608 0.00777262486006497 NA NA NA hsa-let-7a-2-3p CHRD -1.30646060964956 1.05363588067753e-14 0.643081464361437 0.00226381764531491 MirTarget -0.272645412472333 8.08335237089072e-11 NA NA NA hsa-let-7d-5p CHRD 0.410958462607207 6.07808182756787e-06 0.643081464361437 0.00226381764531491 MirTarget;miRNATAP -0.76923545518416 3.69579499425558e-23 NA NA NA hsa-let-7g-3p CHRD 0.5854327663695 0.000371711766083627 0.643081464361437 0.00226381764531491 MirTarget -0.386082992677401 2.40311520153789e-19 NA NA NA hsa-let-7g-5p CHRD 0.0200025784917734 0.791635298815256 0.643081464361437 0.00226381764531491 MirTarget;miRNATAP -0.703022574426774 1.56994154115734e-13 NA NA NA hsa-let-7i-5p CHRD -0.333419326258177 3.56960810786801e-08 0.643081464361437 0.00226381764531491 MirTarget;miRNATAP -0.941754610147491 2.05853715388535e-15 NA NA NA hsa-miR-196b-5p CHRD -0.302231359742807 0.0833893928085868 0.643081464361437 0.00226381764531491 miRNATAP -0.21439911483115 1.94841963347834e-07 NA NA NA hsa-miR-455-3p CHRD 0.678392920628872 0.000327758844555877 0.643081464361437 0.00226381764531491 miRNATAP -0.391985696776891 3.45537050249205e-26 NA NA NA hsa-miR-98-5p CHRD 0.656336869298973 9.03113188590466e-15 0.643081464361437 0.00226381764531491 MirTarget -0.733946495195942 8.35827564110485e-19 NA NA NA hsa-miR-361-5p CREBBP -0.0996867547900457 0.095428250126326 -0.207546077707359 0.000564449557347142 PITA;miRanda;miRNATAP -0.169327426710038 1.27069129226647e-06 NA NA NA hsa-miR-374a-3p CREBBP 0.34122393953022 2.28714105382856e-05 -0.207546077707359 0.000564449557347142 miRNATAP -0.118175129899399 3.92114134022804e-06 NA NA NA hsa-miR-590-3p CREBBP 1.27438512890514 1.03164723481469e-23 -0.207546077707359 0.000564449557347142 PITA;miRanda;mirMAP;miRNATAP -0.100564166407458 8.68617817381304e-10 NA NA NA hsa-let-7d-5p DCN 0.410958462607207 6.07808182756787e-06 -2.24189494854445 3.67472421736277e-35 MirTarget -0.402955453367597 1.36046683351098e-08 NA NA NA hsa-let-7g-5p DCN 0.0200025784917734 0.791635298815256 -2.24189494854445 3.67472421736277e-35 MirTarget -0.303726193013156 0.000445615748265266 NA NA NA hsa-miR-181a-5p DCN 0.635863607630183 6.72486918157744e-11 -2.24189494854445 3.67472421736277e-35 MirTarget -0.252752904906497 0.000128654659180327 NA NA NA hsa-miR-181b-5p DCN 1.22749257795094 1.21998198830919e-27 -2.24189494854445 3.67472421736277e-35 MirTarget -0.396219797750911 6.579807345297e-13 NA NA NA hsa-miR-181c-5p DCN 0.574847839298605 4.51287502066478e-07 -2.24189494854445 3.67472421736277e-35 MirTarget -0.293525013757079 1.96602577911095e-07 NA NA NA hsa-miR-181d-5p DCN 0.782618466877349 1.2821116358212e-09 -2.24189494854445 3.67472421736277e-35 MirTarget -0.324337485034118 5.14263997474735e-11 NA NA NA hsa-miR-186-5p DCN -0.426987301460247 1.04129380549315e-05 -2.24189494854445 3.67472421736277e-35 mirMAP -0.232351831760879 0.000515456316071472 NA NA NA hsa-miR-320b DCN 0.412787504747938 0.00113457276903985 -2.24189494854445 3.67472421736277e-35 miRanda -0.29535554536257 7.09538047060049e-09 NA NA NA hsa-miR-342-3p DCN 1.21944481975657 6.81914373001202e-19 -2.24189494854445 3.67472421736277e-35 miRanda -0.287211968356635 3.67914088909684e-10 NA NA NA hsa-miR-590-3p DCN 1.27438512890514 1.03164723481469e-23 -2.24189494854445 3.67472421736277e-35 MirTarget;PITA;miRanda;mirMAP -0.52916176505448 1.07716522597725e-25 NA NA NA hsa-miR-7-1-3p DCN 0.686579567507582 1.20731554448806e-07 -2.24189494854445 3.67472421736277e-35 mirMAP -0.417482536233104 1.14965997799617e-17 NA NA NA hsa-miR-98-5p DCN 0.656336869298973 9.03113188590466e-15 -2.24189494854445 3.67472421736277e-35 MirTarget -0.691424742968624 1.12225257396507e-20 NA NA NA hsa-let-7a-5p E2F5 -0.210286642041636 0.0072546234707717 1.22057233889235 9.21129944070499e-24 MirTarget;TargetScan;miRNATAP -0.252632998058136 4.16489182218567e-06 NA NA NA hsa-let-7b-5p E2F5 -0.54215483448257 7.21347617597858e-08 1.22057233889235 9.21129944070499e-24 miRNAWalker2_validate;MirTarget;miRNATAP -0.208792220314713 7.49186766676534e-07 NA NA NA hsa-let-7c-5p E2F5 -1.9415540533505 9.55250745007793e-48 1.22057233889235 9.21129944070499e-24 MirTarget -0.287024192767085 1.82102078575949e-22 NA NA NA hsa-miR-1-3p E2F5 -1.92761220689044 2.14541307073875e-29 1.22057233889235 9.21129944070499e-24 MirTarget -0.197646452192756 1.30207517693539e-16 NA NA NA hsa-miR-154-5p E2F5 -1.13112031257162 1.15116720453339e-14 1.22057233889235 9.21129944070499e-24 MirTarget;miRNATAP -0.129030803814152 8.20733931583736e-06 27398145;27074041 MicroRNA 154 inhibits growth and invasion of breast cancer cells through targeting E2F5; Luciferase reporter assay and Western blot was used to verify E2F transcription factor 5 protein E2F5 as a novel target gene of miR-154; E2F5 was identified as a target of miR-154 and its expression was inversely correlated with miR-154 expression in clinical breast cancer tissues; In addition downregulation of E2F5 in MCF7 cells had similar effect on cell proliferation cycle migration and invasion by miR-154 induced; These findings indicate that miR-154 acts as a tumor suppressor by targeting E2F5 suggesting miR-154 as a potential therapeutic target for the treatment of breast cancer;The effects of forced miR-154-5p expression or E2F transcription factor 5 E2F5 knockdown on PCa cells were evaluated by cell proliferation flow cytometry cell migration and invasion assays as well as by Western blot analysis; The forced expression of miR-154-5p or E2F5 knockdown significantly restrained cell growth as well as the migratory and invasive capabilities; Hence E2F5 is a direct target gene of miR-154-5p miR-154-5p may play an important role as an inhibitor of proliferation migration and invasion of PCa by targeting E2F5 in PCa cell lines ;cell migration breast cancer;prostate cancer hsa-miR-199a-5p E2F5 -0.314703593105081 0.00909304983051124 1.22057233889235 9.21129944070499e-24 miRanda -0.303224745258506 3.21231496741469e-18 NA NA NA hsa-miR-199b-5p E2F5 -1.37022396448377 3.25758057539223e-26 1.22057233889235 9.21129944070499e-24 miRanda -0.336927501630045 2.45223402264681e-27 NA NA NA hsa-miR-335-5p E2F5 -2.61355235628987 2.6462884165886e-51 1.22057233889235 9.21129944070499e-24 miRNAWalker2_validate -0.122773312196824 1.03172977893697e-07 NA NA NA hsa-miR-337-3p E2F5 -2.14274617598363 2.70942896809734e-43 1.22057233889235 9.21129944070499e-24 MirTarget;PITA -0.228149350398858 4.79737697762728e-19 NA NA NA hsa-miR-34c-5p E2F5 -0.0896438810345765 0.557016551646841 1.22057233889235 9.21129944070499e-24 MirTarget;PITA;miRanda;miRNATAP -0.132406436564757 2.42305122201497e-06 NA NA NA hsa-miR-378a-3p E2F5 -1.79882978380301 1.05005373951733e-38 1.22057233889235 9.21129944070499e-24 miRNAWalker2_validate -0.188942985347346 1.06561996595534e-10 NA NA NA hsa-miR-495-3p E2F5 -1.67685437612894 1.70634429769052e-34 1.22057233889235 9.21129944070499e-24 MirTarget -0.238991250342934 6.79487454514355e-16 NA NA NA hsa-miR-106b-5p EP300 1.22477789913175 2.31787213143326e-32 -0.378121576001413 5.1159454625656e-06 miRNATAP -0.191649543350323 2.95239597393248e-13 NA NA NA hsa-miR-181b-5p EP300 1.22749257795094 1.21998198830919e-27 -0.378121576001413 5.1159454625656e-06 miRNAWalker2_validate -0.187884049605316 7.93444158362854e-15 NA NA NA hsa-miR-20a-5p EP300 0.44979911120222 0.000602386964327228 -0.378121576001413 5.1159454625656e-06 miRNATAP -0.151748232339608 1.59846335234487e-12 NA NA NA hsa-miR-25-3p EP300 -0.00546790775985073 0.944061771389468 -0.378121576001413 5.1159454625656e-06 miRNAWalker2_validate -0.101950779775411 0.00585001386907759 NA NA NA hsa-miR-361-3p EP300 -0.0370446538644886 0.624902392829872 -0.378121576001413 5.1159454625656e-06 PITA -0.139187579360879 0.000249736724501524 NA NA NA hsa-miR-320b FST 0.412787504747938 0.00113457276903985 -0.895876392733032 3.19692454088565e-06 PITA;miRanda -0.17874343125668 0.00065840102461666 NA NA NA hsa-miR-425-5p FST 0.719898949241718 6.01079610190374e-08 -0.895876392733032 3.19692454088565e-06 MirTarget -0.237691780818936 1.47116649494804e-06 NA NA NA hsa-miR-505-3p FST -0.530462599544864 7.71645736541597e-05 -0.895876392733032 3.19692454088565e-06 MirTarget -0.201062759837977 4.31672871793938e-05 NA NA NA hsa-miR-590-3p FST 1.27438512890514 1.03164723481469e-23 -0.895876392733032 3.19692454088565e-06 miRanda -0.46419329824237 4.76862887557746e-19 NA NA NA hsa-miR-769-5p FST 0.564871766265874 8.16695101656941e-10 -0.895876392733032 3.19692454088565e-06 MirTarget;miRNATAP -0.577653562671636 2.58108369401135e-16 NA NA NA hsa-miR-342-3p GDF5 1.21944481975657 6.81914373001202e-19 -2.29225103887934 1.9647166261975e-19 miRanda -0.50811169463946 4.33189323314316e-16 NA NA NA hsa-let-7d-5p GDF6 0.410958462607207 6.07808182756787e-06 -0.388623710302829 0.0268119680640758 MirTarget;miRNATAP -0.176724465068045 0.00771130569639958 NA NA NA hsa-let-7g-5p GDF6 0.0200025784917734 0.791635298815256 -0.388623710302829 0.0268119680640758 MirTarget;miRNATAP -0.211224881140262 0.00858834057253194 NA NA NA hsa-miR-141-3p GDF6 2.99777540204168 1.26370498493024e-78 -0.388623710302829 0.0268119680640758 TargetScan -0.245691412390661 3.02382137529226e-13 NA NA NA hsa-miR-141-5p GDF6 2.38411349683216 4.56310582620282e-58 -0.388623710302829 0.0268119680640758 mirMAP -0.215895062193741 8.08164935094237e-09 NA NA NA hsa-miR-148a-3p GDF6 0.706969798912638 5.52538085480485e-09 -0.388623710302829 0.0268119680640758 miRNATAP -0.209173958939414 2.08641938433008e-05 NA NA NA hsa-miR-193a-3p GDF6 0.310617999804917 0.00477640270974957 -0.388623710302829 0.0268119680640758 miRanda -0.290674999402467 9.37034296350216e-08 NA NA NA hsa-miR-200b-3p GDF6 2.11744072703209 1.66710572104191e-43 -0.388623710302829 0.0268119680640758 TargetScan -0.235189970868671 1.83473115362667e-10 NA NA NA hsa-miR-30d-3p GDF6 0.264544633563642 0.00755023189129747 -0.388623710302829 0.0268119680640758 miRNATAP -0.286565347127467 2.41745328700732e-06 NA NA NA hsa-miR-324-5p GDF6 0.211552647440779 0.139408130311654 -0.388623710302829 0.0268119680640758 miRanda -0.184054486893969 1.15350981651547e-05 NA NA NA hsa-miR-330-3p GDF6 0.432728362037032 0.00041335506960812 -0.388623710302829 0.0268119680640758 PITA;miRNATAP -0.168151107267975 0.000719056491443551 NA NA NA hsa-miR-339-5p GDF6 -0.211548290465418 0.0685885445822389 -0.388623710302829 0.0268119680640758 miRanda -0.192415748893717 0.000207169195414695 NA NA NA hsa-miR-429 GDF6 2.84108892259147 3.88520896426515e-64 -0.388623710302829 0.0268119680640758 PITA;miRanda;miRNATAP -0.195401437731195 3.19568062685289e-09 NA NA NA hsa-miR-532-3p GDF6 -0.395473145042459 0.00686714288452761 -0.388623710302829 0.0268119680640758 PITA;miRNATAP -0.165327279580597 5.57617374827518e-05 NA NA NA hsa-miR-590-3p GDF6 1.27438512890514 1.03164723481469e-23 -0.388623710302829 0.0268119680640758 miRanda;mirMAP -0.26694954665499 2.56785783669174e-08 NA NA NA hsa-miR-98-5p GDF6 0.656336869298973 9.03113188590466e-15 -0.388623710302829 0.0268119680640758 MirTarget -0.289588587887271 3.72588812074349e-05 NA NA NA hsa-let-7a-3p ID1 0.466622567891891 3.70886257943079e-07 -1.07844448572194 4.92075309042249e-15 MirTarget;miRNATAP -0.288666797905502 2.68339123612235e-08 NA NA NA hsa-let-7b-3p ID1 -0.778498268330274 1.04357662300776e-10 -1.07844448572194 4.92075309042249e-15 MirTarget;miRNATAP -0.213661368629314 5.17627112591308e-08 NA NA NA hsa-let-7f-1-3p ID1 0.37532726250321 0.00156021688753682 -1.07844448572194 4.92075309042249e-15 MirTarget -0.168472615663934 3.82568771699861e-05 NA NA NA hsa-miR-16-2-3p ID1 0.286355254959005 0.0256946046884474 -1.07844448572194 4.92075309042249e-15 MirTarget -0.106045291832553 0.00490760564452169 NA NA NA hsa-miR-192-5p ID1 1.33366224451777 9.5116159697107e-29 -1.07844448572194 4.92075309042249e-15 miRNAWalker2_validate -0.376309448355852 2.01378377203536e-23 NA NA NA hsa-miR-29b-3p ID1 0.438847962603729 6.46722433236121e-05 -1.07844448572194 4.92075309042249e-15 MirTarget -0.188784664946449 1.46064015731403e-05 22249264;24662327 Incubation of lung cancer cells with the Src inhibitor saracatinib led to the upregulation of several miRNAs including miR-29b which was the most highly upregulated miRNA with predicted binding to the ID1 3'-untranslated region UTR; Luciferase reporter assays confirmed direct binding of miR-29b to the ID1 3'-UTR; Expression of miR-29b suppressed ID1 levels and significantly reduced migration and invasion;Id 1 a protein repressed by miR 29b facilitates the TGFβ1 induced epithelial mesenchymal transition in human ovarian cancer cells ; lung cancer;ovarian cancer hsa-miR-330-5p ID1 0.626063225953928 3.42215028606779e-09 -1.07844448572194 4.92075309042249e-15 miRNATAP -0.286099397613906 1.45878882256605e-10 NA NA NA hsa-miR-331-3p ID1 0.74441480542886 1.17071235477799e-07 -1.07844448572194 4.92075309042249e-15 MirTarget -0.386656508179256 2.65685537692846e-32 NA NA NA hsa-miR-3127-5p ID3 0.903405128081314 1.1325923598273e-12 -0.335852360833754 0.00106834093973443 MirTarget -0.189307261244136 2.85579647453505e-12 NA NA NA hsa-miR-3607-3p ID3 0.00697875745616461 0.972073275173643 -0.335852360833754 0.00106834093973443 MirTarget -0.158567216278868 4.69887121107217e-20 NA NA NA hsa-miR-590-3p ID3 1.27438512890514 1.03164723481469e-23 -0.335852360833754 0.00106834093973443 miRanda -0.142133101437323 4.28063069242757e-07 NA NA NA hsa-miR-769-5p ID3 0.564871766265874 8.16695101656941e-10 -0.335852360833754 0.00106834093973443 PITA -0.267539804472467 1.22678247541039e-12 NA NA NA hsa-miR-142-3p ID4 1.53951237846104 2.06769936282034e-17 -2.95709093256383 7.3098592491371e-46 miRanda -0.1596411705813 8.83747406478823e-05 NA NA NA hsa-miR-192-5p ID4 1.33366224451777 9.5116159697107e-29 -2.95709093256383 7.3098592491371e-46 miRNAWalker2_validate -0.401382751792557 2.84729793814996e-11 NA NA NA hsa-miR-324-3p ID4 0.404877731996915 0.000340036423920834 -2.95709093256383 7.3098592491371e-46 miRNAWalker2_validate;PITA -0.276969829786112 3.25522149805004e-05 NA NA NA hsa-miR-330-5p ID4 0.626063225953928 3.42215028606779e-09 -2.95709093256383 7.3098592491371e-46 miRanda -0.339362600232543 1.52442544121729e-06 NA NA NA hsa-miR-339-5p ID4 -0.211548290465418 0.0685885445822389 -2.95709093256383 7.3098592491371e-46 miRanda -0.181737763314177 0.0053118301994014 NA NA NA hsa-miR-340-5p ID4 1.0857159627596 4.94471062546756e-24 -2.95709093256383 7.3098592491371e-46 miRNAWalker2_validate -0.248120227632158 0.000292569442494505 NA NA NA hsa-miR-342-3p ID4 1.21944481975657 6.81914373001202e-19 -2.95709093256383 7.3098592491371e-46 MirTarget;PITA;miRanda -0.561987569665707 4.7041735736719e-27 24475217 miR 342 regulates BRCA1 expression through modulation of ID4 in breast cancer; To investigate at functional level the role of miR-342 in the pathogenesis of breast cancer we focused our attention on its "in silico" predicted putative target gene ID4 a transcription factor of the helix-loop-helix protein family whose expression is inversely correlated with that of ER; We functionally validated the interaction between ID4 and miR-342 in a reporter Luciferase system; Based on these findings we hypothesized that regulation of ID4 mediated by miR-342 could be involved in the pathogenesis of breast cancer by downregulating BRCA1 expression; Overexpression of miR-342 in these cells reduced ID4 and increased BRCA1 expression supporting a possible role of this mechanism in breast cancer; In the ER-positive MCF7 and in the BRCA1-mutant HCC1937 cell lines miR-342 over-expression only reduced ID4 breast cancer hsa-miR-345-5p ID4 0.639728356429512 0.00013070715719672 -2.95709093256383 7.3098592491371e-46 MirTarget -0.191495513045981 1.97893812018554e-05 NA NA NA hsa-miR-590-3p ID4 1.27438512890514 1.03164723481469e-23 -2.95709093256383 7.3098592491371e-46 miRNAWalker2_validate;miRanda -0.268807026509474 8.44097012405478e-06 NA NA NA hsa-miR-629-3p ID4 1.25035919247365 3.91361135469024e-14 -2.95709093256383 7.3098592491371e-46 MirTarget -0.375561354103374 2.07412660127111e-16 NA NA NA hsa-miR-125a-5p IFNG -0.635694700253268 3.6703235721638e-11 0.469173337259002 0.065979531036782 miRanda -0.633234290202444 1.34334735769906e-12 NA NA NA hsa-miR-10b-5p INHBA -2.10996264627796 7.36811595736367e-72 2.92269165168259 7.0734436456195e-54 miRNAWalker2_validate -0.315991143995102 3.56059166646068e-09 NA NA NA hsa-miR-125b-2-3p INHBA -1.92374904783012 2.30779527653582e-38 2.92269165168259 7.0734436456195e-54 mirMAP -0.192569276917189 1.45917212337729e-05 NA NA NA hsa-miR-126-5p INHBA -1.27745588751177 2.96000918537631e-30 2.92269165168259 7.0734436456195e-54 mirMAP -0.365446042383557 8.00635434475456e-10 NA NA NA hsa-miR-195-3p INHBA -1.49582726452416 6.53261924105147e-40 2.92269165168259 7.0734436456195e-54 mirMAP -0.457507775640633 2.0024779119854e-15 NA NA NA hsa-miR-26a-5p INHBA -0.481180084102235 1.82368246174758e-10 2.92269165168259 7.0734436456195e-54 mirMAP -0.806583685372971 2.83412051156283e-19 NA NA NA hsa-miR-26b-5p INHBA -0.331527896896866 0.000551258576575092 2.92269165168259 7.0734436456195e-54 mirMAP -0.386714706799185 7.94265255522648e-08 NA NA NA hsa-miR-30a-5p INHBA -0.392489994825279 0.00954894667761676 2.92269165168259 7.0734436456195e-54 mirMAP -0.339337086240446 5.62802453652228e-14 NA NA NA hsa-miR-30b-5p INHBA -0.46540603860146 2.4709940429591e-05 2.92269165168259 7.0734436456195e-54 mirMAP -0.488363240944963 2.76553416939545e-15 NA NA NA hsa-miR-30c-5p INHBA -0.393222674580066 8.06961465717306e-05 2.92269165168259 7.0734436456195e-54 mirMAP -0.554034099183663 5.80415262756076e-16 NA NA NA hsa-miR-30d-5p INHBA -0.247082219011045 0.00406717930063148 2.92269165168259 7.0734436456195e-54 mirMAP -0.560261794318746 2.73850414996811e-12 NA NA NA hsa-miR-30e-5p INHBA 0.293491764699475 0.000372291967271834 2.92269165168259 7.0734436456195e-54 mirMAP -0.193445893339914 0.0222601575529368 NA NA NA hsa-miR-335-3p INHBA -1.88448538773649 2.09538234398335e-32 2.92269165168259 7.0734436456195e-54 mirMAP -0.358331308407745 2.90058922815416e-18 NA NA NA hsa-miR-374a-5p INHBA -0.239709888246804 0.00309819667153627 2.92269165168259 7.0734436456195e-54 mirMAP -0.501460291948885 4.49896836409766e-09 NA NA NA hsa-miR-374b-5p INHBA -0.466781429946153 1.17238311619116e-08 2.92269165168259 7.0734436456195e-54 mirMAP -0.423669398924089 4.99022706092223e-07 NA NA NA hsa-miR-381-3p INHBA -1.28028930293369 1.61402949866141e-23 2.92269165168259 7.0734436456195e-54 mirMAP -0.118520102206024 0.024855760154819 NA NA NA hsa-miR-664a-3p INHBA -0.237699857923843 0.0197071390183375 2.92269165168259 7.0734436456195e-54 mirMAP -0.329267118225509 1.28384451198929e-06 NA NA NA hsa-let-7a-3p INHBB 0.466622567891891 3.70886257943079e-07 -1.41026732865016 4.33672138785341e-19 mirMAP -0.331545721479258 3.04305684692188e-08 NA NA NA hsa-let-7f-1-3p INHBB 0.37532726250321 0.00156021688753682 -1.41026732865016 4.33672138785341e-19 mirMAP -0.256626544267918 4.74419192139722e-08 NA NA NA hsa-miR-130b-3p INHBB 1.38122163823846 1.00932179737836e-26 -1.41026732865016 4.33672138785341e-19 miRNATAP -0.381630575170115 9.92225932758929e-21 NA NA NA hsa-miR-130b-5p INHBB 1.0573161199584 2.55177349228739e-12 -1.41026732865016 4.33672138785341e-19 mirMAP -0.308775024147184 3.2108494433814e-18 NA NA NA hsa-miR-19a-3p INHBB 0.817507952171848 3.76285090469625e-08 -1.41026732865016 4.33672138785341e-19 miRNATAP -0.249766887068599 8.51257274377858e-12 NA NA NA hsa-miR-19b-3p INHBB 0.139124391010031 0.255658553872934 -1.41026732865016 4.33672138785341e-19 miRNATAP -0.245341846364512 5.22835551023035e-08 NA NA NA hsa-miR-301a-3p INHBB 1.32170168375632 2.12280368957514e-15 -1.41026732865016 4.33672138785341e-19 miRNATAP -0.257370391267214 1.82089541732649e-15 NA NA NA hsa-miR-429 INHBB 2.84108892259147 3.88520896426515e-64 -1.41026732865016 4.33672138785341e-19 miRNATAP -0.210500602533215 3.36016908073308e-12 NA NA NA hsa-miR-454-3p INHBB 1.28177672191095 6.84024979484587e-21 -1.41026732865016 4.33672138785341e-19 miRNATAP -0.300070731677732 2.01102414021318e-14 NA NA NA hsa-miR-590-3p INHBB 1.27438512890514 1.03164723481469e-23 -1.41026732865016 4.33672138785341e-19 miRanda -0.374892224098306 7.33051194100577e-18 NA NA NA hsa-miR-590-5p INHBB 0.746515607868274 8.51300479640125e-09 -1.41026732865016 4.33672138785341e-19 miRanda -0.316300899501723 3.91367503989617e-14 NA NA NA hsa-miR-143-5p LEFTY1 -1.08813426434718 6.46387834906802e-10 0.400164793015522 0.018469082015912 MirTarget -0.119568390843974 0.000253606509886093 NA NA NA hsa-miR-192-5p LEFTY2 1.33366224451777 9.5116159697107e-29 -2.24240742544647 7.36401202055137e-15 MirTarget -0.638420889641026 1.25196068350713e-15 NA NA NA hsa-miR-338-3p LEFTY2 0.0799903526884966 0.575137668326679 -2.24240742544647 7.36401202055137e-15 miRanda -0.20755507497088 0.00325901540293462 NA NA NA hsa-miR-339-5p LEFTY2 -0.211548290465418 0.0685885445822389 -2.24240742544647 7.36401202055137e-15 miRanda -0.377171635832493 1.29129734779697e-05 NA NA NA hsa-miR-625-5p LEFTY2 0.728939236913178 5.97591217674307e-08 -2.24240742544647 7.36401202055137e-15 MirTarget -0.588222186492936 6.68599338061733e-15 NA NA NA hsa-miR-141-3p LTBP1 2.99777540204168 1.26370498493024e-78 -0.181835521424575 0.143896069693686 MirTarget -0.14099266757721 4.14111813979571e-09 NA NA NA hsa-miR-200a-3p LTBP1 2.55218480823434 2.96135446816238e-51 -0.181835521424575 0.143896069693686 MirTarget -0.155545472524258 3.39347655502809e-11 NA NA NA hsa-miR-26a-5p LTBP1 -0.481180084102235 1.82368246174758e-10 -0.181835521424575 0.143896069693686 miRNATAP -0.132224939088067 0.0191280702092279 NA NA NA hsa-miR-26b-5p LTBP1 -0.331527896896866 0.000551258576575092 -0.181835521424575 0.143896069693686 miRNATAP -0.143867739059559 0.00122143259712523 NA NA NA hsa-miR-7-1-3p LTBP1 0.686579567507582 1.20731554448806e-07 -0.181835521424575 0.143896069693686 MirTarget -0.17161457210631 1.26152528774934e-07 NA NA NA hsa-miR-29c-3p MAPK1 -0.0652732378039769 0.563774115756922 -0.282469104608855 4.85723866828359e-06 mirMAP -0.107930467813368 8.09848447187363e-09 NA NA NA hsa-miR-361-5p MAPK1 -0.0996867547900457 0.095428250126326 -0.282469104608855 4.85723866828359e-06 PITA;miRanda;mirMAP -0.263780179525808 1.39108568009728e-13 NA NA NA hsa-miR-3913-5p MAPK1 0.71890413546147 2.61153227160465e-13 -0.282469104608855 4.85723866828359e-06 mirMAP -0.145979254174869 5.54224263447113e-12 NA NA NA hsa-miR-660-5p MAPK1 0.406910761707485 0.000156175371762464 -0.282469104608855 4.85723866828359e-06 mirMAP -0.144747929471906 1.05117786154161e-13 NA NA NA hsa-miR-197-3p MAPK3 -0.526589453596294 3.61594599437195e-06 -0.0806112580526674 0.201094437565328 miRNATAP -0.106370513582673 1.47526386613596e-08 NA NA NA hsa-miR-21-5p MYC 2.32007501846389 3.08394781855554e-137 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate -0.270190862069706 5.76701615920235e-10 22072622 In contrast the levels of β-catenin TCF/LEF activity and the expression of c-Myc Cyclin-D which are increased in CSCs are also augmented in miR-21 overexpressing colon cancer cells accompanied by an increased sphere forming ability in vitro and tumor formation in SCID mice colon cancer hsa-miR-34a-5p MYC 0.129201805242403 0.133261654068224 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate;miRTarBase -0.216308870548993 0.000129276161670072 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 2.84108892259147 3.88520896426515e-64 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate -0.108453248703558 4.76591679996824e-05 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-126-5p NOG -1.27745588751177 2.96000918537631e-30 -0.838623753380888 3.81907058171582e-05 mirMAP;miRNATAP -0.166907094216349 0.00589468378929364 NA NA NA hsa-miR-142-5p NOG 1.16509303143593 1.96641162209073e-13 -0.838623753380888 3.81907058171582e-05 miRNATAP -0.14733740273363 0.000713947895715875 NA NA NA hsa-miR-148a-3p NOG 0.706969798912638 5.52538085480485e-09 -0.838623753380888 3.81907058171582e-05 MirTarget;miRNATAP -0.160898206457741 0.00507229210468836 NA NA NA hsa-miR-148b-3p NOG 1.0552576751879 1.6679285705231e-29 -0.838623753380888 3.81907058171582e-05 MirTarget -0.582391985124335 3.41820665130688e-16 NA NA NA hsa-miR-186-5p NOG -0.426987301460247 1.04129380549315e-05 -0.838623753380888 3.81907058171582e-05 MirTarget;miRNATAP -0.277056736375451 0.000125196317691307 NA NA NA hsa-miR-193a-3p NOG 0.310617999804917 0.00477640270974957 -0.838623753380888 3.81907058171582e-05 miRanda -0.275126823769095 1.51379024971198e-05 NA NA NA hsa-miR-200b-3p NOG 2.11744072703209 1.66710572104191e-43 -0.838623753380888 3.81907058171582e-05 MirTarget;TargetScan -0.249677853882184 6.65837437098035e-09 NA NA NA hsa-miR-200c-3p NOG 2.07038651806183 6.84613386286599e-51 -0.838623753380888 3.81907058171582e-05 MirTarget;miRNATAP -0.347080893351845 1.63065263678635e-13 NA NA NA hsa-miR-26b-3p NOG -0.62588114643887 3.30712936204727e-06 -0.838623753380888 3.81907058171582e-05 MirTarget -0.159500347625355 0.0021102075628094 NA NA NA hsa-miR-340-5p NOG 1.0857159627596 4.94471062546756e-24 -0.838623753380888 3.81907058171582e-05 MirTarget -0.168351963860764 0.00820812926837844 NA NA NA hsa-miR-3607-3p NOG 0.00697875745616461 0.972073275173643 -0.838623753380888 3.81907058171582e-05 MirTarget;miRNATAP -0.160771713330531 4.44816935738285e-06 NA NA NA hsa-miR-429 NOG 2.84108892259147 3.88520896426515e-64 -0.838623753380888 3.81907058171582e-05 MirTarget;PITA;miRanda;miRNATAP -0.221990432368383 7.7539335905232e-09 NA NA NA hsa-miR-141-3p PITX2 2.99777540204168 1.26370498493024e-78 -0.446534217465074 0.0204393455572554 TargetScan;miRNATAP -0.223717264715575 1.74572061948343e-09 NA NA NA hsa-miR-142-3p PITX2 1.53951237846104 2.06769936282034e-17 -0.446534217465074 0.0204393455572554 miRanda -0.123411579888614 0.000537635375930706 NA NA NA hsa-miR-200a-3p PITX2 2.55218480823434 2.96135446816238e-51 -0.446534217465074 0.0204393455572554 miRNATAP -0.2225102743152 1.03072167409031e-09 NA NA NA hsa-miR-30d-3p PITX2 0.264544633563642 0.00755023189129747 -0.446534217465074 0.0204393455572554 miRNATAP -0.332002742964576 6.35544311038629e-07 NA NA NA hsa-miR-324-5p PITX2 0.211552647440779 0.139408130311654 -0.446534217465074 0.0204393455572554 miRanda -0.170316421259242 0.000223031249664272 NA NA NA hsa-miR-342-3p PITX2 1.21944481975657 6.81914373001202e-19 -0.446534217465074 0.0204393455572554 miRanda -0.307217323830506 4.38245157775331e-11 NA NA NA hsa-miR-590-3p PITX2 1.27438512890514 1.03164723481469e-23 -0.446534217465074 0.0204393455572554 miRanda -0.221058944956453 2.86214909987604e-05 NA NA NA hsa-miR-590-5p PITX2 0.746515607868274 8.51300479640125e-09 -0.446534217465074 0.0204393455572554 PITA;miRanda;miRNATAP -0.18617831800215 0.000230247172854942 NA NA NA hsa-miR-17-3p PPP2CA 0.721439431208839 7.95900548819742e-10 0.355964216272682 1.3164574185057e-12 MirTarget -0.133330530645377 1.5958296816568e-20 NA NA NA hsa-miR-425-5p PPP2CB 0.719898949241718 6.01079610190374e-08 -0.508468028837195 3.29413468049735e-15 miRNAWalker2_validate -0.1434305833926 3.027811361313e-18 NA NA NA hsa-miR-590-3p PPP2CB 1.27438512890514 1.03164723481469e-23 -0.508468028837195 3.29413468049735e-15 miRanda -0.10511834935696 4.0251015210593e-09 NA NA NA hsa-miR-128-3p PPP2R1B 0.90296715955238 9.925204823863e-23 -1.24069690315388 3.45729939213988e-47 MirTarget -0.109583188561297 0.000963818534703709 NA NA NA hsa-miR-146b-5p PPP2R1B 0.631041661167954 6.20366593452965e-08 -1.24069690315388 3.45729939213988e-47 miRanda -0.141184532696467 1.00140046078863e-07 NA NA NA hsa-miR-15a-5p PPP2R1B 0.812445324157528 4.50263417099822e-20 -1.24069690315388 3.45729939213988e-47 MirTarget -0.195736754254626 1.30304715741401e-08 NA NA NA hsa-miR-200b-3p PPP2R1B 2.11744072703209 1.66710572104191e-43 -1.24069690315388 3.45729939213988e-47 MirTarget -0.190114683335312 5.20726875191601e-24 NA NA NA hsa-miR-200c-3p PPP2R1B 2.07038651806183 6.84613386286599e-51 -1.24069690315388 3.45729939213988e-47 MirTarget -0.226923946553815 2.68646974148231e-28 21248297 Western blotting showed that knockdown of miR-200c expression was associated with increased expression of PPP2R1B a subunit of protein phosphatase 2A which resulted in reduced expression of phospho-Akt esophageal cancer hsa-miR-30d-3p PPP2R1B 0.264544633563642 0.00755023189129747 -1.24069690315388 3.45729939213988e-47 mirMAP -0.157184793756038 6.17261426855798e-07 NA NA NA hsa-miR-429 PPP2R1B 2.84108892259147 3.88520896426515e-64 -1.24069690315388 3.45729939213988e-47 MirTarget;miRanda;miRNATAP -0.148415458438853 1.78268855237664e-18 NA NA NA hsa-miR-195-3p RBL1 -1.49582726452416 6.53261924105147e-40 0.258171772260236 0.0557349984337416 MirTarget;mirMAP -0.136404640726563 0.000466660213562153 NA NA NA hsa-miR-199a-5p RBL1 -0.314703593105081 0.00909304983051124 0.258171772260236 0.0557349984337416 miRanda -0.16646935754867 1.35556669022578e-05 NA NA NA hsa-miR-199b-5p RBL1 -1.37022396448377 3.25758057539223e-26 0.258171772260236 0.0557349984337416 miRanda -0.19173327799932 2.62627664412876e-08 NA NA NA hsa-miR-106b-5p RBL2 1.22477789913175 2.31787213143326e-32 -0.777587758921412 2.2971094499013e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.263898121665047 3.64871109439286e-25 NA NA NA hsa-miR-107 RBL2 0.678998026350662 2.56224148930538e-16 -0.777587758921412 2.2971094499013e-22 miRanda -0.214816939727489 9.7538516274009e-11 NA NA NA hsa-miR-17-5p RBL2 0.599531757298529 1.07318660415906e-05 -0.777587758921412 2.2971094499013e-22 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.11529529846799 1.64112965057067e-08 NA NA NA hsa-miR-20a-5p RBL2 0.44979911120222 0.000602386964327228 -0.777587758921412 2.2971094499013e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.182553356518434 3.46682203211793e-18 NA NA NA hsa-miR-429 RBL2 2.84108892259147 3.88520896426515e-64 -0.777587758921412 2.2971094499013e-22 miRanda -0.114178875200587 9.05972696116893e-14 NA NA NA hsa-miR-93-5p RBL2 1.01788600209314 1.24312921618126e-21 -0.777587758921412 2.2971094499013e-22 MirTarget;miRNATAP -0.257781038097889 8.64400419240358e-25 NA NA NA hsa-miR-139-5p RBX1 -3.25846663863766 2.62018989415003e-112 0.647024426818053 3.59244462846658e-20 miRanda -0.138659130309957 7.99349725093936e-22 NA NA NA hsa-miR-107 ROCK1 0.678998026350662 2.56224148930538e-16 -0.577010438503248 1.15807774989766e-11 miRanda -0.214652817656713 7.4445514442289e-10 NA NA NA hsa-miR-429 ROCK1 2.84108892259147 3.88520896426515e-64 -0.577010438503248 1.15807774989766e-11 miRanda -0.107368538530982 2.74283719948915e-11 NA NA NA hsa-miR-200b-3p ROCK2 2.11744072703209 1.66710572104191e-43 -1.42053003829191 2.83260805693116e-25 TargetScan -0.238045362418837 5.70621727270586e-16 NA NA NA hsa-miR-340-5p ROCK2 1.0857159627596 4.94471062546756e-24 -1.42053003829191 2.83260805693116e-25 mirMAP -0.395127263389571 3.35868529258436e-20 NA NA NA hsa-miR-429 ROCK2 2.84108892259147 3.88520896426515e-64 -1.42053003829191 2.83260805693116e-25 PITA;miRanda;miRNATAP -0.205818358236693 4.93110698663187e-15 NA NA NA hsa-miR-103a-3p RPS6KB1 0.610673390034345 1.63113920514646e-12 -0.0571936206706596 0.498093695192352 miRNAWalker2_validate -0.13730715753257 3.30989618940789e-05 NA NA NA hsa-miR-148a-5p RPS6KB1 0.572692271754695 2.14306251522796e-06 -0.0571936206706596 0.498093695192352 MirTarget;miRNATAP -0.171064566688249 3.39982513466234e-13 NA NA NA hsa-miR-181a-5p RPS6KB1 0.635863607630183 6.72486918157744e-11 -0.0571936206706596 0.498093695192352 MirTarget;miRNATAP -0.130436776786364 8.76017102192071e-06 NA NA NA hsa-miR-181c-5p RPS6KB1 0.574847839298605 4.51287502066478e-07 -0.0571936206706596 0.498093695192352 MirTarget;miRNATAP -0.186058639495696 7.95661299115965e-14 NA NA NA hsa-miR-181d-5p RPS6KB1 0.782618466877349 1.2821116358212e-09 -0.0571936206706596 0.498093695192352 MirTarget -0.164885796389909 5.09783807829002e-14 NA NA NA hsa-miR-218-5p RPS6KB1 -1.02621788318234 2.9221925445771e-23 -0.0571936206706596 0.498093695192352 miRNATAP -0.15390061742019 1.35815707120652e-08 25943352 We found that decreased miR-218 expression in GBM cells also increased the expression of genes encoding additional upstream and downstream components of RTK signaling pathways including the RTK platelet-derived growth factor receptor α PDGFRα and the kinases ribosomal S6 kinase 2 RSK2 and S6 kinase 1 S6K1 that collectively overrode the negative feedback mechanism glioblastoma hsa-miR-223-3p RPS6KB1 -0.966406159689943 7.90612601654887e-12 -0.0571936206706596 0.498093695192352 MirTarget -0.140401561003547 1.98539879754319e-12 NA NA NA hsa-miR-27a-3p RPS6KB1 0.388496361379095 1.42373532086331e-05 -0.0571936206706596 0.498093695192352 MirTarget;miRNATAP -0.152883993564015 2.01871224053452e-06 NA NA NA hsa-miR-30a-5p RPS6KB1 -0.392489994825279 0.00954894667761676 -0.0571936206706596 0.498093695192352 mirMAP;miRNATAP -0.117644522086258 4.71701520431133e-10 NA NA NA hsa-miR-340-5p RPS6KB1 1.0857159627596 4.94471062546756e-24 -0.0571936206706596 0.498093695192352 mirMAP -0.12986566290195 6.5302066469287e-07 NA NA NA hsa-miR-361-5p RPS6KB1 -0.0996867547900457 0.095428250126326 -0.0571936206706596 0.498093695192352 miRanda -0.315724779040643 8.68560752083352e-11 NA NA NA hsa-miR-369-3p RPS6KB1 0.0880848299432269 0.48519534195924 -0.0571936206706596 0.498093695192352 MirTarget;PITA -0.109811993589112 1.74070420680125e-06 NA NA NA hsa-miR-381-3p RPS6KB1 -1.28028930293369 1.61402949866141e-23 -0.0571936206706596 0.498093695192352 MirTarget -0.11550176003524 1.23132177175341e-07 NA NA NA hsa-miR-455-5p RPS6KB1 0.284641224662773 0.0357572339594277 -0.0571936206706596 0.498093695192352 MirTarget;PITA;miRanda -0.195839125781244 5.6227516619354e-21 NA NA NA hsa-miR-542-3p RPS6KB1 0.568822103820889 8.5699075257651e-07 -0.0571936206706596 0.498093695192352 miRNATAP -0.146106785368595 3.33819415150885e-09 NA NA NA hsa-miR-125a-5p RPS6KB2 -0.635694700253268 3.6703235721638e-11 1.06459449292244 1.07488926981491e-32 miRanda -0.276064765205245 1.34823621720886e-17 NA NA NA hsa-miR-26b-5p RPS6KB2 -0.331527896896866 0.000551258576575092 1.06459449292244 1.07488926981491e-32 miRNAWalker2_validate -0.119704281563459 0.00031805074232755 NA NA NA hsa-miR-130a-3p SKP1 -1.15024914519431 6.51290317952496e-19 0.0738382124630679 0.231791018805648 MirTarget -0.139641825685064 4.17514374271046e-19 NA NA NA hsa-miR-130b-3p SKP1 1.38122163823846 1.00932179737836e-26 0.0738382124630679 0.231791018805648 MirTarget -0.106102178127117 1.72601795720608e-11 NA NA NA hsa-miR-222-3p SKP1 -0.429279381480379 0.00103945569781115 0.0738382124630679 0.231791018805648 MirTarget -0.10501825880122 4.51166430229641e-11 NA NA NA hsa-miR-181a-5p SMAD2 0.635863607630183 6.72486918157744e-11 -0.328226721195286 1.10147955577876e-10 mirMAP -0.115122429788219 8.47012412856965e-11 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 1.22749257795094 1.21998198830919e-27 -0.328226721195286 1.10147955577876e-10 mirMAP -0.112879931507918 3.62142519922135e-14 NA NA NA hsa-miR-340-5p SMAD2 1.0857159627596 4.94471062546756e-24 -0.328226721195286 1.10147955577876e-10 MirTarget -0.145840275032375 8.51041709723394e-21 NA NA NA hsa-miR-361-3p SMAD2 -0.0370446538644886 0.624902392829872 -0.328226721195286 1.10147955577876e-10 miRNATAP -0.128521633108847 3.38235989722682e-08 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-miR-361-5p SMAD2 -0.0996867547900457 0.095428250126326 -0.328226721195286 1.10147955577876e-10 MirTarget -0.168440579811925 1.40285064429544e-08 NA NA NA hsa-miR-542-3p SMAD2 0.568822103820889 8.5699075257651e-07 -0.328226721195286 1.10147955577876e-10 PITA -0.104251622984305 3.31535587210055e-12 NA NA NA hsa-miR-155-5p SMAD3 1.09766314984151 4.55650930885814e-15 -0.590930154862025 2.18041656438712e-13 miRNAWalker2_validate -0.161248941325708 6.88088611744894e-17 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-15a-5p SMAD3 0.812445324157528 4.50263417099822e-20 -0.590930154862025 2.18041656438712e-13 MirTarget -0.127238885845652 3.99211956272264e-05 NA NA NA hsa-miR-15b-5p SMAD3 0.788659356634696 1.13678211092534e-11 -0.590930154862025 2.18041656438712e-13 MirTarget -0.103829420518863 1.25324379645245e-05 NA NA NA hsa-miR-17-5p SMAD3 0.599531757298529 1.07318660415906e-05 -0.590930154862025 2.18041656438712e-13 miRNAWalker2_validate -0.144062907194855 1.0396353881575e-12 NA NA NA hsa-miR-185-5p SMAD3 0.482334746589337 3.68475879959415e-09 -0.590930154862025 2.18041656438712e-13 MirTarget -0.139641114876277 4.17733017511663e-05 NA NA NA hsa-miR-18a-5p SMAD3 0.969066793715868 1.69069796425892e-08 -0.590930154862025 2.18041656438712e-13 miRNAWalker2_validate -0.145191271950291 4.28063578565896e-20 23249750 The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling glioblastoma hsa-miR-1976 SMAD3 0.289190368864725 0.00167092758216584 -0.590930154862025 2.18041656438712e-13 MirTarget -0.121630671332983 6.52049342337766e-05 NA NA NA hsa-miR-28-5p SMAD3 -0.14267073663385 0.0497619246260571 -0.590930154862025 2.18041656438712e-13 miRNATAP -0.120097254990824 0.00200641803458376 NA NA NA hsa-miR-330-5p SMAD3 0.626063225953928 3.42215028606779e-09 -0.590930154862025 2.18041656438712e-13 miRanda -0.106180722787539 5.07248451793749e-05 NA NA NA hsa-miR-429 SMAD3 2.84108892259147 3.88520896426515e-64 -0.590930154862025 2.18041656438712e-13 miRNATAP -0.102063359852527 2.55000912428033e-11 NA NA NA hsa-miR-590-3p SMAD3 1.27438512890514 1.03164723481469e-23 -0.590930154862025 2.18041656438712e-13 miRanda -0.163099760014662 1.73477690677951e-13 NA NA NA hsa-miR-671-5p SMAD3 1.55248047544015 7.7377784125886e-33 -0.590930154862025 2.18041656438712e-13 MirTarget -0.132445297015047 2.33568059728177e-10 NA NA NA hsa-miR-769-5p SMAD3 0.564871766265874 8.16695101656941e-10 -0.590930154862025 2.18041656438712e-13 miRNATAP -0.121091427985316 6.14487597806327e-05 NA NA NA hsa-miR-106b-5p SMAD4 1.22477789913175 2.31787213143326e-32 -0.624967182926059 1.70248077700642e-24 mirMAP;miRNATAP -0.132593131707842 2.60050027244317e-11 NA NA NA hsa-miR-146b-5p SMAD4 0.631041661167954 6.20366593452965e-08 -0.624967182926059 1.70248077700642e-24 PITA;miRanda;miRNATAP -0.13881112685924 1.84558785229961e-14 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-155-5p SMAD4 1.09766314984151 4.55650930885814e-15 -0.624967182926059 1.70248077700642e-24 miRNAWalker2_validate -0.114314883374695 1.83733755300191e-14 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-21-3p SMAD4 2.17476065946878 5.15299442583591e-75 -0.624967182926059 1.70248077700642e-24 mirMAP -0.142251679213528 1.79438322002583e-18 NA NA NA hsa-miR-27a-3p SMAD4 0.388496361379095 1.42373532086331e-05 -0.624967182926059 1.70248077700642e-24 MirTarget -0.107318887613883 7.95509636261065e-06 NA NA NA hsa-miR-32-5p SMAD4 1.38676603945192 2.29428299685976e-34 -0.624967182926059 1.70248077700642e-24 mirMAP -0.104053876543456 9.38449586813502e-09 NA NA NA hsa-miR-361-5p SMAD4 -0.0996867547900457 0.095428250126326 -0.624967182926059 1.70248077700642e-24 mirMAP -0.13420862344236 0.000247319809078657 NA NA NA hsa-miR-589-5p SMAD4 0.367182541239722 1.67804815542873e-05 -0.624967182926059 1.70248077700642e-24 miRNATAP -0.184456440754787 1.53364140974385e-13 NA NA NA hsa-miR-93-5p SMAD4 1.01788600209314 1.24312921618126e-21 -0.624967182926059 1.70248077700642e-24 miRNAWalker2_validate;mirMAP;miRNATAP -0.118636275861089 1.4710971943885e-09 NA NA NA hsa-miR-106b-5p SMAD5 1.22477789913175 2.31787213143326e-32 -0.545010310954351 1.14150258900381e-14 MirTarget;miRNATAP -0.223679527076449 1.0601999123081e-23 NA NA NA hsa-miR-130b-3p SMAD5 1.38122163823846 1.00932179737836e-26 -0.545010310954351 1.14150258900381e-14 MirTarget;miRNATAP -0.103519076322907 1.92070227254941e-08 NA NA NA hsa-miR-155-5p SMAD5 1.09766314984151 4.55650930885814e-15 -0.545010310954351 1.14150258900381e-14 miRNAWalker2_validate;miRTarBase -0.165640259153535 6.62054395693184e-23 20133617 Targeting of SMAD5 links microRNA 155 to the TGF beta pathway and lymphomagenesis; Using unbiased genome-wide approaches in DLBCL we discovered that the oncogenic microRNA-155 miR-155 directly targets the bone morphogenetic protein BMP-responsive transcriptional factor SMAD5; In confirmatory experiments RNAi-based SMAD5 knockdown recapitulated in vitro and in vivo the effects miR-155 overexpression; Furthermore in primary DLBCLs miR-155 overexpression inhibited SMAD5 expression and disrupted its activity as defined by individual and global analyses of its transcriptional targets; Together our data helped explain miR-155 function highlighted a hitherto unappreciated role of SMAD5 in lymphoma biology and defined a unique mechanism used by cancer cells to escape TGF-beta's growth-inhibitory effects lymphoma hsa-miR-15a-5p SMAD5 0.812445324157528 4.50263417099822e-20 -0.545010310954351 1.14150258900381e-14 MirTarget;miRNATAP -0.28309402402264 8.1950679424613e-27 NA NA NA hsa-miR-17-5p SMAD5 0.599531757298529 1.07318660415906e-05 -0.545010310954351 1.14150258900381e-14 MirTarget;TargetScan;miRNATAP -0.130886886030224 1.5069406772606e-13 NA NA NA hsa-miR-19a-3p SMAD5 0.817507952171848 3.76285090469625e-08 -0.545010310954351 1.14150258900381e-14 MirTarget;miRNATAP -0.126975084432939 3.71096081688784e-15 NA NA NA hsa-miR-20a-5p SMAD5 0.44979911120222 0.000602386964327228 -0.545010310954351 1.14150258900381e-14 MirTarget;miRNATAP -0.20427043007251 1.19685654895982e-29 NA NA NA hsa-miR-340-5p SMAD5 1.0857159627596 4.94471062546756e-24 -0.545010310954351 1.14150258900381e-14 MirTarget -0.168506474975631 1.73300625528468e-14 NA NA NA hsa-miR-362-5p SMAD5 -0.248676340901797 0.0726089851456282 -0.545010310954351 1.14150258900381e-14 mirMAP -0.127604450522941 3.17271383110155e-13 NA NA NA hsa-miR-374a-5p SMAD5 -0.239709888246804 0.00309819667153627 -0.545010310954351 1.14150258900381e-14 mirMAP -0.160252655854768 1.24796945463573e-07 NA NA NA hsa-miR-500a-5p SMAD5 0.209805801129289 0.119177819862398 -0.545010310954351 1.14150258900381e-14 mirMAP -0.159391338048836 1.57570963463228e-18 NA NA NA hsa-miR-532-5p SMAD5 0.0386976222860582 0.682018574136515 -0.545010310954351 1.14150258900381e-14 miRNATAP -0.193902491520723 5.50007562180344e-14 NA NA NA hsa-miR-590-3p SMAD5 1.27438512890514 1.03164723481469e-23 -0.545010310954351 1.14150258900381e-14 MirTarget;PITA;miRanda;miRNATAP -0.115113637124871 3.79175944135625e-09 NA NA NA hsa-miR-93-5p SMAD5 1.01788600209314 1.24312921618126e-21 -0.545010310954351 1.14150258900381e-14 MirTarget;miRNATAP -0.221519222334676 5.38905029663131e-24 NA NA NA hsa-miR-125a-5p SMAD6 -0.635694700253268 3.6703235721638e-11 -0.553769610178168 7.58185937032009e-08 miRanda -0.147230804491131 5.90680183588677e-05 NA NA NA hsa-miR-186-5p SMAD6 -0.426987301460247 1.04129380549315e-05 -0.553769610178168 7.58185937032009e-08 MirTarget -0.153046884016817 2.89903473805251e-05 NA NA NA hsa-miR-330-5p SMAD6 0.626063225953928 3.42215028606779e-09 -0.553769610178168 7.58185937032009e-08 miRanda -0.168856954307778 3.63129698842582e-07 NA NA NA hsa-miR-429 SMAD6 2.84108892259147 3.88520896426515e-64 -0.553769610178168 7.58185937032009e-08 miRanda -0.1319320154552 1.11141762738611e-11 NA NA NA hsa-miR-590-3p SMAD6 1.27438512890514 1.03164723481469e-23 -0.553769610178168 7.58185937032009e-08 miRanda -0.17590836322682 4.74377703172686e-10 NA NA NA hsa-miR-590-3p SMAD7 1.27438512890514 1.03164723481469e-23 -0.126914187586443 0.0344522313625721 miRanda -0.104268769035866 1.5864687173614e-10 NA NA NA hsa-let-7a-3p SMAD9 0.466622567891891 3.70886257943079e-07 -2.31742580561337 5.2619763732892e-36 mirMAP -0.339440208972422 2.31797137796656e-06 NA NA NA hsa-miR-106b-5p SMAD9 1.22477789913175 2.31787213143326e-32 -2.31742580561337 5.2619763732892e-36 miRNAWalker2_validate;mirMAP -0.491436185819539 6.42844511485369e-16 NA NA NA hsa-miR-16-2-3p SMAD9 0.286355254959005 0.0256946046884474 -2.31742580561337 5.2619763732892e-36 mirMAP -0.15099386534087 0.00371866896738571 NA NA NA hsa-miR-17-5p SMAD9 0.599531757298529 1.07318660415906e-05 -2.31742580561337 5.2619763732892e-36 mirMAP -0.191658337518681 7.50740122113064e-05 NA NA NA hsa-miR-200b-3p SMAD9 2.11744072703209 1.66710572104191e-43 -2.31742580561337 5.2619763732892e-36 TargetScan -0.433450642046697 1.02300809234532e-27 NA NA NA hsa-miR-20a-5p SMAD9 0.44979911120222 0.000602386964327228 -2.31742580561337 5.2619763732892e-36 mirMAP -0.233520082362627 3.47290466993624e-06 NA NA NA hsa-miR-27a-3p SMAD9 0.388496361379095 1.42373532086331e-05 -2.31742580561337 5.2619763732892e-36 MirTarget;miRNATAP -0.156498842575649 0.0351039542254818 NA NA NA hsa-miR-320b SMAD9 0.412787504747938 0.00113457276903985 -2.31742580561337 5.2619763732892e-36 MirTarget;miRanda -0.183261427871827 0.000478898758737045 NA NA NA hsa-miR-330-3p SMAD9 0.432728362037032 0.00041335506960812 -2.31742580561337 5.2619763732892e-36 mirMAP;miRNATAP -0.202632761930593 0.000213705585293478 NA NA NA hsa-miR-3913-5p SMAD9 0.71890413546147 2.61153227160465e-13 -2.31742580561337 5.2619763732892e-36 MirTarget -0.271542382003726 4.71665561492278e-05 NA NA NA hsa-miR-429 SMAD9 2.84108892259147 3.88520896426515e-64 -2.31742580561337 5.2619763732892e-36 miRanda;miRNATAP -0.411129629446905 2.43654737649883e-31 NA NA NA hsa-miR-590-3p SMAD9 1.27438512890514 1.03164723481469e-23 -2.31742580561337 5.2619763732892e-36 mirMAP -0.314485431663451 2.47706353518049e-09 NA NA NA hsa-miR-629-3p SMAD9 1.25035919247365 3.91361135469024e-14 -2.31742580561337 5.2619763732892e-36 MirTarget -0.129618035464659 0.00148949379270889 NA NA NA hsa-miR-664a-3p SMAD9 -0.237699857923843 0.0197071390183375 -2.31742580561337 5.2619763732892e-36 mirMAP -0.17306969418458 0.00803844869901249 NA NA NA hsa-miR-93-5p SMAD9 1.01788600209314 1.24312921618126e-21 -2.31742580561337 5.2619763732892e-36 mirMAP -0.539678071552204 1.29330103067119e-19 NA NA NA hsa-miR-140-3p SP1 -1.25844395244141 5.29222651039892e-33 -0.354351925158745 1.46585727332836e-11 PITA -0.133134295207693 3.89559470917654e-16 NA NA NA hsa-miR-181a-5p SP1 0.635863607630183 6.72486918157744e-11 -0.354351925158745 1.46585727332836e-11 mirMAP -0.170550722145103 3.8462533080952e-21 NA NA NA hsa-miR-181b-5p SP1 1.22749257795094 1.21998198830919e-27 -0.354351925158745 1.46585727332836e-11 mirMAP -0.162663427578237 6.39298452310672e-27 NA NA NA hsa-miR-21-5p SP1 2.32007501846389 3.08394781855554e-137 -0.354351925158745 1.46585727332836e-11 miRNAWalker2_validate;miRTarBase -0.155768447861795 3.88544448292272e-22 NA NA NA hsa-miR-27a-3p SP1 0.388496361379095 1.42373532086331e-05 -0.354351925158745 1.46585727332836e-11 miRNAWalker2_validate;miRTarBase -0.116008129999336 8.74979285561679e-09 NA NA NA hsa-miR-361-5p SP1 -0.0996867547900457 0.095428250126326 -0.354351925158745 1.46585727332836e-11 PITA;miRanda;mirMAP -0.255788486421106 3.35834132000944e-17 NA NA NA hsa-miR-374a-3p SP1 0.34122393953022 2.28714105382856e-05 -0.354351925158745 1.46585727332836e-11 mirMAP -0.135511716994984 1.52454394154091e-09 NA NA NA hsa-miR-532-5p SP1 0.0386976222860582 0.682018574136515 -0.354351925158745 1.46585727332836e-11 mirMAP -0.136379164595477 9.26014529036054e-13 NA NA NA hsa-miR-671-5p SP1 1.55248047544015 7.7377784125886e-33 -0.354351925158745 1.46585727332836e-11 PITA -0.110400251438575 2.24476925034465e-16 NA NA NA hsa-miR-365a-3p TFDP1 -1.45032725192851 2.37888098061118e-37 0.475732630523186 1.02158117512193e-10 MirTarget -0.119562336866465 2.06776358163436e-08 NA NA NA hsa-miR-744-5p TGFB1 0.114590984077262 0.312916425462546 0.9572932995293 2.60884198670166e-26 miRNAWalker2_validate;miRNATAP -0.166126823806423 2.82828117413693e-09 NA NA NA hsa-miR-107 TGFB2 0.678998026350662 2.56224148930538e-16 -0.568239705690126 0.00206510120463672 miRanda -0.401875565283925 8.76701815465238e-08 NA NA NA hsa-miR-141-3p TGFB2 2.99777540204168 1.26370498493024e-78 -0.568239705690126 0.00206510120463672 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.201139839320628 1.72029232417547e-08 NA NA NA hsa-miR-148b-3p TGFB2 1.0552576751879 1.6679285705231e-29 -0.568239705690126 0.00206510120463672 MirTarget -0.422618628558287 7.82755899138552e-11 NA NA NA hsa-miR-149-5p TGFB2 0.218233101703391 0.261629158371175 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.129221359501958 7.02534131250114e-05 NA NA NA hsa-miR-193a-3p TGFB2 0.310617999804917 0.00477640270974957 -0.568239705690126 0.00206510120463672 MirTarget;miRanda;miRNATAP -0.385790006047712 1.31529188795393e-11 NA NA NA hsa-miR-193b-3p TGFB2 -0.0550374855074773 0.65382485898551 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.171503498781225 0.000913844156376696 NA NA NA hsa-miR-200a-3p TGFB2 2.55218480823434 2.96135446816238e-51 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.157197308079383 7.61768751897913e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-29b-3p TGFB2 0.438847962603729 6.46722433236121e-05 -0.568239705690126 0.00206510120463672 miRTarBase;MirTarget;miRNATAP -0.435812547346718 1.64777033866721e-14 NA NA NA hsa-miR-29c-3p TGFB2 -0.0652732378039769 0.563774115756922 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.393270636676739 1.42982951467692e-12 NA NA NA hsa-miR-301a-3p TGFB2 1.32170168375632 2.12280368957514e-15 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.168650734197616 6.85924013793372e-06 NA NA NA hsa-miR-330-3p TGFB2 0.432728362037032 0.00041335506960812 -0.568239705690126 0.00206510120463672 miRNATAP -0.169099911709115 0.00123359688318399 NA NA NA hsa-miR-330-5p TGFB2 0.626063225953928 3.42215028606779e-09 -0.568239705690126 0.00206510120463672 miRanda -0.231096330328837 9.82035598821339e-05 NA NA NA hsa-miR-331-5p TGFB2 0.682437632502949 4.10871642662371e-11 -0.568239705690126 0.00206510120463672 miRNATAP -0.256828592209254 2.39839780265118e-05 NA NA NA hsa-miR-362-5p TGFB2 -0.248676340901797 0.0726089851456282 -0.568239705690126 0.00206510120463672 MirTarget -0.113727114004023 0.0130357663477879 NA NA NA hsa-miR-375 TGFB2 2.09893673049766 1.68351780396203e-16 -0.568239705690126 0.00206510120463672 miRNAWalker2_validate -0.118032596246175 1.14664596099986e-06 NA NA NA hsa-miR-429 TGFB2 2.84108892259147 3.88520896426515e-64 -0.568239705690126 0.00206510120463672 miRNATAP -0.113931562701627 0.00112595441618086 NA NA NA hsa-miR-454-3p TGFB2 1.28177672191095 6.84024979484587e-21 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.21652241903686 1.80168797038491e-06 NA NA NA hsa-miR-590-3p TGFB2 1.27438512890514 1.03164723481469e-23 -0.568239705690126 0.00206510120463672 mirMAP -0.218778123275247 1.55472558560304e-05 NA NA NA hsa-miR-590-5p TGFB2 0.746515607868274 8.51300479640125e-09 -0.568239705690126 0.00206510120463672 miRanda;miRNATAP -0.127583678067132 0.00859946694127918 NA NA NA hsa-let-7a-3p TGFB3 0.466622567891891 3.70886257943079e-07 0.82398957056453 1.83180841509129e-11 MirTarget -0.23002281448221 5.95409654478238e-07 NA NA NA hsa-let-7f-1-3p TGFB3 0.37532726250321 0.00156021688753682 0.82398957056453 1.83180841509129e-11 MirTarget -0.195594535331808 6.10557486170201e-08 NA NA NA hsa-miR-151a-5p TGFB3 0.509210376738198 3.17540030607215e-07 0.82398957056453 1.83180841509129e-11 MirTarget -0.460270915838936 5.41462985077644e-29 NA NA NA hsa-miR-26b-3p TGFB3 -0.62588114643887 3.30712936204727e-06 0.82398957056453 1.83180841509129e-11 MirTarget -0.166318643088715 1.09180542813277e-07 NA NA NA hsa-miR-29a-3p TGFB3 -0.699539666833076 1.13935003139957e-13 0.82398957056453 1.83180841509129e-11 miRNAWalker2_validate -0.215592947893623 1.26387377494944e-06 NA NA NA hsa-miR-29b-3p TGFB3 0.438847962603729 6.46722433236121e-05 0.82398957056453 1.83180841509129e-11 miRTarBase -0.300724044682202 2.93536952356929e-15 NA NA NA hsa-miR-511-5p TGFB3 -2.27545475897362 3.84085514050558e-36 0.82398957056453 1.83180841509129e-11 MirTarget -0.161630488068991 4.28099557548626e-13 NA NA NA hsa-miR-590-3p TGFB3 1.27438512890514 1.03164723481469e-23 0.82398957056453 1.83180841509129e-11 miRanda -0.276040958504426 1.7943368211393e-16 NA NA NA hsa-miR-629-3p TGFB3 1.25035919247365 3.91361135469024e-14 0.82398957056453 1.83180841509129e-11 MirTarget -0.184738491466436 9.18913270065683e-13 NA NA NA hsa-let-7a-5p TGFBR1 -0.210286642041636 0.0072546234707717 -0.276773756857041 0.00374479166499862 TargetScan;miRNATAP -0.135014125369019 0.00134477571196012 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC colorectal cancer hsa-miR-101-3p TGFBR1 -0.126035286271986 0.145997832808138 -0.276773756857041 0.00374479166499862 miRNAWalker2_validate;miRNATAP -0.226110526180146 2.07174805788194e-09 NA NA NA hsa-miR-128-3p TGFBR1 0.90296715955238 9.925204823863e-23 -0.276773756857041 0.00374479166499862 miRNAWalker2_validate;miRTarBase -0.157338866756433 5.76850179866576e-06 NA NA NA hsa-miR-200b-3p TGFBR1 2.11744072703209 1.66710572104191e-43 -0.276773756857041 0.00374479166499862 mirMAP -0.133382190063293 2.90573705377005e-11 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-320a TGFBR1 -0.287921276129346 0.00141693637596294 -0.276773756857041 0.00374479166499862 PITA;miRanda;miRNATAP -0.136624380256683 0.000172858923508737 NA NA NA hsa-miR-338-3p TGFBR1 0.0799903526884966 0.575137668326679 -0.276773756857041 0.00374479166499862 miRanda -0.16505256729074 3.45773945956773e-13 NA NA NA hsa-miR-340-5p TGFBR1 1.0857159627596 4.94471062546756e-24 -0.276773756857041 0.00374479166499862 mirMAP -0.126480744659732 2.00427959104962e-05 NA NA NA hsa-miR-361-5p TGFBR1 -0.0996867547900457 0.095428250126326 -0.276773756857041 0.00374479166499862 miRanda;mirMAP;miRNATAP -0.343826208469508 4.82441885336511e-10 NA NA NA hsa-miR-429 TGFBR1 2.84108892259147 3.88520896426515e-64 -0.276773756857041 0.00374479166499862 miRanda;miRNATAP -0.101210444459427 1.79034747294782e-08 NA NA NA hsa-miR-98-5p TGFBR1 0.656336869298973 9.03113188590466e-15 -0.276773756857041 0.00374479166499862 miRNAWalker2_validate -0.153945603415794 5.62215521493057e-05 NA NA NA hsa-miR-106a-5p TGFBR2 0.574594373206545 0.000145868284001732 -2.39529308737339 4.9899056025782e-85 miRTarBase;miRNATAP -0.167004125374202 5.11178559030175e-08 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 1.22477789913175 2.31787213143326e-32 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.583213497349775 2.44964235169299e-45 NA NA NA hsa-miR-107 TGFBR2 0.678998026350662 2.56224148930538e-16 -2.39529308737339 4.9899056025782e-85 miRanda;miRNATAP -0.530917906321599 1.66581882091816e-22 NA NA NA hsa-miR-130b-3p TGFBR2 1.38122163823846 1.00932179737836e-26 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRNATAP -0.355697993280506 3.73635681408915e-25 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 0.599531757298529 1.07318660415906e-05 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.344837157501155 3.26279419912174e-25 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 0.969066793715868 1.69069796425892e-08 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate -0.233316456798081 1.26332307500906e-18 NA NA NA hsa-miR-19a-3p TGFBR2 0.817507952171848 3.76285090469625e-08 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRNATAP -0.295433323573397 3.17340161137166e-22 NA NA NA hsa-miR-19b-3p TGFBR2 0.139124391010031 0.255658553872934 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRNATAP -0.23529469963531 5.83073772392392e-10 NA NA NA hsa-miR-20a-5p TGFBR2 0.44979911120222 0.000602386964327228 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;miRNATAP -0.346418250547717 1.79003902635661e-23 NA NA NA hsa-miR-20b-5p TGFBR2 0.78236583455125 8.7938334801223e-05 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.101055475114644 1.4278146071271e-05 NA NA NA hsa-miR-21-5p TGFBR2 2.32007501846389 3.08394781855554e-137 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;miRNATAP -0.537594809270263 3.47307989185754e-40 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-301a-3p TGFBR2 1.32170168375632 2.12280368957514e-15 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.317266296975964 1.73201531962553e-32 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-320b TGFBR2 0.412787504747938 0.00113457276903985 -2.39529308737339 4.9899056025782e-85 miRanda;miRNATAP -0.208017816637935 1.58734456312155e-08 NA NA NA hsa-miR-340-5p TGFBR2 1.0857159627596 4.94471062546756e-24 -2.39529308737339 4.9899056025782e-85 mirMAP -0.314168975517319 6.41119882395371e-14 NA NA NA hsa-miR-429 TGFBR2 2.84108892259147 3.88520896426515e-64 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.404995702801572 1.14853648012577e-64 NA NA NA hsa-miR-454-3p TGFBR2 1.28177672191095 6.84024979484587e-21 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.384614615164931 1.36686238358356e-32 NA NA NA hsa-miR-590-3p TGFBR2 1.27438512890514 1.03164723481469e-23 -2.39529308737339 4.9899056025782e-85 miRanda -0.338025545666787 3.04278770804611e-20 NA NA NA hsa-miR-590-5p TGFBR2 0.746515607868274 8.51300479640125e-09 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.286652524899627 4.12566791851325e-16 NA NA NA hsa-miR-9-5p TGFBR2 0.734772328078424 0.00261982843636383 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.11967052909348 2.52866655443074e-10 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 -0.342420481092807 0.000732275969501111 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate -0.223515332507838 1.18491745689284e-06 NA NA NA hsa-miR-93-5p TGFBR2 1.01788600209314 1.24312921618126e-21 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRNATAP -0.609999323446729 8.30075605455623e-52 NA NA NA hsa-miR-155-5p THBS1 1.09766314984151 4.55650930885814e-15 -0.0614785645873859 0.62138763262321 miRNAWalker2_validate;mirMAP -0.133542323510001 7.64645600006924e-06 NA NA NA hsa-miR-16-1-3p THBS1 1.30142784811196 2.53343713753744e-29 -0.0614785645873859 0.62138763262321 MirTarget -0.140131478293771 0.000198601030104097 NA NA NA hsa-miR-17-5p THBS1 0.599531757298529 1.07318660415906e-05 -0.0614785645873859 0.62138763262321 miRNAWalker2_validate -0.211166755871651 7.35327505985432e-12 NA NA NA hsa-miR-181a-5p THBS1 0.635863607630183 6.72486918157744e-11 -0.0614785645873859 0.62138763262321 mirMAP -0.150019822568732 0.000545990600769292 NA NA NA hsa-miR-181b-5p THBS1 1.22749257795094 1.21998198830919e-27 -0.0614785645873859 0.62138763262321 mirMAP -0.1533233095909 2.76267327611462e-05 NA NA NA hsa-miR-181c-5p THBS1 0.574847839298605 4.51287502066478e-07 -0.0614785645873859 0.62138763262321 mirMAP -0.147290024790751 7.4630964763336e-05 NA NA NA hsa-miR-18a-5p THBS1 0.969066793715868 1.69069796425892e-08 -0.0614785645873859 0.62138763262321 MirTarget -0.181152396860618 8.69562380186631e-14 NA NA NA hsa-miR-19a-3p THBS1 0.817507952171848 3.76285090469625e-08 -0.0614785645873859 0.62138763262321 MirTarget;mirMAP -0.214042484472341 2.35179044480412e-14 NA NA NA hsa-miR-19b-3p THBS1 0.139124391010031 0.255658553872934 -0.0614785645873859 0.62138763262321 MirTarget;mirMAP -0.25361005913269 1.79395476818e-13 NA NA NA hsa-miR-20a-5p THBS1 0.44979911120222 0.000602386964327228 -0.0614785645873859 0.62138763262321 miRNAWalker2_validate -0.30952947364433 1.36418642869234e-22 NA NA NA hsa-miR-32-5p THBS1 1.38676603945192 2.29428299685976e-34 -0.0614785645873859 0.62138763262321 mirMAP -0.19932792247749 2.72222895176776e-08 NA NA NA hsa-miR-455-5p THBS1 0.284641224662773 0.0357572339594277 -0.0614785645873859 0.62138763262321 miRanda -0.181790591068211 5.96114242364848e-09 NA NA NA hsa-miR-500a-5p THBS1 0.209805801129289 0.119177819862398 -0.0614785645873859 0.62138763262321 mirMAP -0.167786316949011 1.51589228334337e-07 NA NA NA hsa-miR-590-3p THBS1 1.27438512890514 1.03164723481469e-23 -0.0614785645873859 0.62138763262321 miRanda -0.175386342682792 2.46112499417128e-07 NA NA NA hsa-miR-590-5p THBS1 0.746515607868274 8.51300479640125e-09 -0.0614785645873859 0.62138763262321 miRanda;mirMAP -0.167667995453039 2.43506908893591e-07 NA NA NA hsa-miR-671-5p THBS1 1.55248047544015 7.7377784125886e-33 -0.0614785645873859 0.62138763262321 MirTarget -0.149992236442967 2.76078556306308e-06 NA NA NA hsa-miR-92a-3p THBS1 -0.342420481092807 0.000732275969501111 -0.0614785645873859 0.62138763262321 miRNAWalker2_validate -0.236223996163107 1.60863345703223e-08 NA NA NA hsa-miR-98-5p THBS1 0.656336869298973 9.03113188590466e-15 -0.0614785645873859 0.62138763262321 miRNAWalker2_validate -0.196108417985267 8.06107193430326e-05 NA NA NA hsa-miR-106b-5p THBS2 1.22477789913175 2.31787213143326e-32 0.769808163205687 9.78636441866493e-07 MirTarget -0.302711566656831 1.58196287774772e-09 NA NA NA hsa-miR-139-5p THBS2 -3.25846663863766 2.62018989415003e-112 0.769808163205687 9.78636441866493e-07 miRanda -0.18351393710485 1.38608699702018e-08 NA NA NA hsa-miR-16-2-3p THBS2 0.286355254959005 0.0256946046884474 0.769808163205687 9.78636441866493e-07 mirMAP -0.266853998218325 2.47345099228546e-10 NA NA NA hsa-miR-17-5p THBS2 0.599531757298529 1.07318660415906e-05 0.769808163205687 9.78636441866493e-07 MirTarget;TargetScan -0.253625690199161 1.06814941199192e-10 NA NA NA hsa-miR-20a-5p THBS2 0.44979911120222 0.000602386964327228 0.769808163205687 9.78636441866493e-07 MirTarget -0.342590656166951 2.95705202030977e-17 NA NA NA hsa-miR-29a-3p THBS2 -0.699539666833076 1.13935003139957e-13 0.769808163205687 9.78636441866493e-07 MirTarget -0.330180674500405 5.19990176669046e-09 NA NA NA hsa-miR-29b-3p THBS2 0.438847962603729 6.46722433236121e-05 0.769808163205687 9.78636441866493e-07 MirTarget -0.440296132980001 7.26973369809758e-20 NA NA NA hsa-miR-29c-3p THBS2 -0.0652732378039769 0.563774115756922 0.769808163205687 9.78636441866493e-07 MirTarget -0.431990941588527 4.39914608500664e-20 NA NA NA hsa-miR-320a THBS2 -0.287921276129346 0.00141693637596294 0.769808163205687 9.78636441866493e-07 mirMAP -0.208219274662831 0.000550427836846861 NA NA NA hsa-miR-320b THBS2 0.412787504747938 0.00113457276903985 0.769808163205687 9.78636441866493e-07 mirMAP -0.124670374856683 0.00370734965981903 NA NA NA hsa-miR-335-3p THBS2 -1.88448538773649 2.09538234398335e-32 0.769808163205687 9.78636441866493e-07 MirTarget;mirMAP -0.104434722339321 0.00143160463399029 NA NA NA hsa-miR-590-3p THBS2 1.27438512890514 1.03164723481469e-23 0.769808163205687 9.78636441866493e-07 miRanda;mirMAP -0.165183001603145 0.000140989548326802 NA NA NA hsa-miR-590-5p THBS2 0.746515607868274 8.51300479640125e-09 0.769808163205687 9.78636441866493e-07 miRanda -0.184580610139702 8.27333563753023e-06 NA NA NA hsa-miR-7-1-3p THBS2 0.686579567507582 1.20731554448806e-07 0.769808163205687 9.78636441866493e-07 MirTarget;mirMAP -0.1868408017881 6.41716930046462e-06 NA NA NA hsa-miR-93-5p THBS2 1.01788600209314 1.24312921618126e-21 0.769808163205687 9.78636441866493e-07 MirTarget -0.273544363928753 3.16076912551438e-08 NA NA NA hsa-miR-326 THBS3 -1.54449030848141 1.04703417845594e-17 0.245441799654582 0.00263276060533888 PITA -0.120857065691596 6.87702237562674e-16 NA NA NA hsa-miR-142-3p THBS4 1.53951237846104 2.06769936282034e-17 -0.661382745748392 0.00786792397096919 miRanda -0.240044523261729 1.6805188940302e-07 NA NA NA hsa-miR-320b THBS4 0.412787504747938 0.00113457276903985 -0.661382745748392 0.00786792397096919 miRanda -0.430826287964397 1.28903705137441e-10 NA NA NA hsa-miR-106b-5p ZFYVE16 1.22477789913175 2.31787213143326e-32 -0.157478145693941 0.0333863072680704 miRNAWalker2_validate -0.272784835996331 3.24737511264162e-33 NA NA NA hsa-miR-107 ZFYVE16 0.678998026350662 2.56224148930538e-16 -0.157478145693941 0.0333863072680704 miRanda -0.223514903985007 6.44816088972544e-14 NA NA NA hsa-miR-17-5p ZFYVE16 0.599531757298529 1.07318660415906e-05 -0.157478145693941 0.0333863072680704 TargetScan -0.196958418309225 4.90709383973576e-28 NA NA NA hsa-miR-186-5p ZFYVE16 -0.426987301460247 1.04129380549315e-05 -0.157478145693941 0.0333863072680704 MirTarget -0.121683675555525 3.02603117893438e-06 NA NA NA hsa-miR-221-3p ZFYVE16 -0.317970198201501 0.00910855267413448 -0.157478145693941 0.0333863072680704 MirTarget -0.2315682936639 8.05151120103469e-31 NA NA NA hsa-miR-222-3p ZFYVE16 -0.429279381480379 0.00103945569781115 -0.157478145693941 0.0333863072680704 miRNAWalker2_validate;MirTarget -0.128742702721979 1.72908845541641e-11 NA NA NA hsa-miR-320b ZFYVE16 0.412787504747938 0.00113457276903985 -0.157478145693941 0.0333863072680704 miRanda -0.10202400711679 3.26093935297166e-07 NA NA NA hsa-miR-340-5p ZFYVE16 1.0857159627596 4.94471062546756e-24 -0.157478145693941 0.0333863072680704 MirTarget -0.141874109162048 5.00773877149816e-10 NA NA NA hsa-miR-361-5p ZFYVE16 -0.0996867547900457 0.095428250126326 -0.157478145693941 0.0333863072680704 miRanda -0.326076241829422 1.66812492825897e-14 NA NA NA hsa-miR-374a-5p ZFYVE16 -0.239709888246804 0.00309819667153627 -0.157478145693941 0.0333863072680704 mirMAP -0.181696558684586 5.99235392938992e-09 NA NA NA hsa-miR-374b-5p ZFYVE16 -0.466781429946153 1.17238311619116e-08 -0.157478145693941 0.0333863072680704 mirMAP -0.173566050004311 1.61280527809941e-08 NA NA NA hsa-miR-455-5p ZFYVE16 0.284641224662773 0.0357572339594277 -0.157478145693941 0.0333863072680704 miRanda;miRNATAP -0.246321294474187 8.44063734163612e-44 NA NA NA hsa-miR-590-3p ZFYVE16 1.27438512890514 1.03164723481469e-23 -0.157478145693941 0.0333863072680704 miRanda -0.1316207265355 6.00534379257308e-11 NA NA NA hsa-miR-590-5p ZFYVE16 0.746515607868274 8.51300479640125e-09 -0.157478145693941 0.0333863072680704 miRanda -0.141719959875293 1.37577137023364e-13 NA NA NA hsa-miR-92a-3p ZFYVE16 -0.342420481092807 0.000732275969501111 -0.157478145693941 0.0333863072680704 miRNAWalker2_validate -0.246794432322245 3.96039223067285e-24 NA NA NA hsa-miR-942-5p ZFYVE16 0.0274758353801279 0.842368857038259 -0.157478145693941 0.0333863072680704 MirTarget -0.153911307617604 1.72509867587362e-17 NA NA NA hsa-miR-106b-5p ZFYVE9 1.22477789913175 2.31787213143326e-32 -0.939573500122968 2.06592186129356e-21 MirTarget;miRNATAP -0.185218690175619 8.52920009344294e-09 NA NA NA hsa-miR-141-5p ZFYVE9 2.38411349683216 4.56310582620282e-58 -0.939573500122968 2.06592186129356e-21 MirTarget;miRNATAP -0.10090128380654 3.27275738623532e-06 NA NA NA hsa-miR-429 ZFYVE9 2.84108892259147 3.88520896426515e-64 -0.939573500122968 2.06592186129356e-21 miRNATAP -0.138287827425906 2.91796972669215e-13 NA NA NA hsa-miR-93-5p ZFYVE9 1.01788600209314 1.24312921618126e-21 -0.939573500122968 2.06592186129356e-21 MirTarget;miRNATAP -0.159671948388364 4.86451485844907e-07 NA NA NA