miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106b-5p AKT3 2.80565545918114 1.14547999022566e-09 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.411504731855899 9.49650030459631e-06 NA NA NA hsa-miR-142-3p AKT3 4.35304505457969 3.10014573651358e-10 -3.32677676487603 1.45486698220293e-05 miRanda -0.161022651130634 0.00933730307368185 NA NA NA hsa-miR-15a-5p AKT3 2.0535411006904 1.91108976398046e-06 -3.32677676487603 1.45486698220293e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.374578960806042 0.000213935533400346 NA NA NA hsa-miR-15b-5p AKT3 3.32329949959268 8.40210501034588e-13 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.254367737995205 0.00570754876367863 NA NA NA hsa-miR-16-5p AKT3 2.93575808220754 2.15436817162977e-10 -3.32677676487603 1.45486698220293e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309870666150618 0.000864570425925272 NA NA NA hsa-miR-29b-3p AKT3 0.666547117072858 0.234055379278093 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.283935483475042 0.000311340903637634 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 2.14185373842821 0.0609400502269891 -3.32677676487603 1.45486698220293e-05 mirMAP -0.221762461081726 2.87831776854007e-06 NA NA NA hsa-miR-362-3p AKT3 0.679952485897744 0.226148468488576 -3.32677676487603 1.45486698220293e-05 miRanda -0.254988730314174 0.00123561088951897 NA NA NA hsa-miR-501-3p AKT3 1.72239979688923 0.0075900263732748 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.18288683695833 0.00732967244086728 NA NA NA hsa-miR-93-5p AKT3 2.65964181833033 2.58315947526774e-08 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.334744595445174 0.000214241376596223 NA NA NA hsa-miR-146b-5p BRAF 1.87569569182453 0.000737241069698886 0.872465997831152 0.0211592092766493 miRanda -0.100930712558287 0.00870229316842184 21874046;26883911;20406109;21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF ;;; thyroid cancer;thyroid cancer;thyroid cancer;thyroid cancer hsa-miR-200b-3p CAB39 5.56167217794639 6.43540045061709e-16 -0.0409146299829386 0.906829073267508 MirTarget;TargetScan -0.100352999717768 0.000212774430958134 NA NA NA hsa-miR-155-5p CAB39L 2.81443182173772 7.42530504828797e-05 -2.96745066051121 2.93701325598714e-06 miRNAWalker2_validate -0.241831898238481 1.50039085328912e-06 NA NA NA hsa-miR-33a-3p CAB39L 2.06269680799532 0.00156436055383943 -2.96745066051121 2.93701325598714e-06 MirTarget -0.178251426679417 0.00143109659013981 NA NA NA hsa-miR-342-3p CAB39L 1.31107714473009 0.0207211910724662 -2.96745066051121 2.93701325598714e-06 miRanda -0.293498963224 4.29222779971308e-06 NA NA NA hsa-miR-590-3p CAB39L 2.35429565068338 2.79601879608564e-06 -2.96745066051121 2.93701325598714e-06 miRanda -0.306580052495799 1.75898573677086e-05 NA NA NA hsa-miR-590-5p CAB39L 1.51400888103768 0.0023888567923017 -2.96745066051121 2.93701325598714e-06 miRanda -0.248916652168609 0.000666338759564629 NA NA NA hsa-miR-101-3p DDIT4 -1.12421603598195 0.0200907284788457 0.477804731551061 0.499952560954147 miRNAWalker2_validate;MirTarget;miRNATAP -0.230006612065332 0.00577054837814306 NA NA NA hsa-miR-200b-3p DDIT4 5.56167217794639 6.43540045061709e-16 0.477804731551061 0.499952560954147 TargetScan -0.146171543167626 0.00840500015299485 NA NA NA hsa-miR-30c-5p EIF4E 0.38723991118075 0.348605235643473 -0.0359303778580173 0.911924839444555 mirMAP -0.125333066167818 0.00521766492206099 NA NA NA hsa-miR-125a-5p EIF4EBP1 -1.32352790615388 0.00714301627309467 1.77505739780472 0.000576225625234467 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.187207630601775 0.00176831220073964 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ovarian cancer hsa-miR-28-5p HIF1A -0.815636722979196 0.0221199948901761 0.731047463819583 0.16939938417342 miRanda -0.252846718732826 0.00322964321035346 NA NA NA hsa-let-7f-1-3p IGF1 1.61507869803314 0.00069342464777815 -4.48455379412262 0.00149155200072234 mirMAP -0.918829913577652 3.87495776454398e-08 NA NA NA hsa-miR-103a-2-5p IGF1 2.77240253557299 0.000302548514615442 -4.48455379412262 0.00149155200072234 mirMAP -0.614783124207912 2.47565479190434e-09 NA NA NA hsa-miR-130b-3p IGF1 3.9204771543282 1.2714917955808e-11 -4.48455379412262 0.00149155200072234 MirTarget -0.479757958716119 0.000356022414865848 NA NA NA hsa-miR-15b-3p IGF1 3.57530146629867 5.89922785773482e-11 -4.48455379412262 0.00149155200072234 mirMAP -0.729097685666816 2.48630408177257e-07 NA NA NA hsa-miR-16-1-3p IGF1 2.83281226969693 7.54359864580834e-09 -4.48455379412262 0.00149155200072234 mirMAP -0.814562134768682 3.05533338766364e-07 NA NA NA hsa-miR-19a-3p IGF1 2.17020503944519 0.00122084653711062 -4.48455379412262 0.00149155200072234 MirTarget -0.581899015817695 7.91751221290163e-07 NA NA NA hsa-miR-19b-1-5p IGF1 1.51335451095424 0.0014717605268143 -4.48455379412262 0.00149155200072234 mirMAP -1.02209573815554 6.70473912999913e-10 NA NA NA hsa-miR-19b-3p IGF1 1.67581705793313 0.000858910586302716 -4.48455379412262 0.00149155200072234 MirTarget -0.831868934390103 1.31473916022842e-07 NA NA NA hsa-miR-20a-3p IGF1 1.9920766549842 0.000624458530894697 -4.48455379412262 0.00149155200072234 mirMAP -0.765905368079341 1.45024350852968e-08 NA NA NA hsa-miR-27a-3p IGF1 1.76094007417453 0.000216137556256765 -4.48455379412262 0.00149155200072234 miRNAWalker2_validate;miRTarBase -1.09876415117095 2.18608056227336e-11 NA NA NA hsa-miR-301a-3p IGF1 1.99338115332667 0.000813358604963724 -4.48455379412262 0.00149155200072234 MirTarget -0.46409260853426 0.000552061816042968 NA NA NA hsa-miR-32-3p IGF1 2.20477794939766 0.0392771274032852 -4.48455379412262 0.00149155200072234 mirMAP -0.547975732700196 3.20639423670354e-05 NA NA NA hsa-miR-33a-3p IGF1 2.06269680799532 0.00156436055383943 -4.48455379412262 0.00149155200072234 MirTarget -0.400091789613134 0.00117684573706475 NA NA NA hsa-miR-452-5p IGF1 2.45466810475361 0.00114794259949532 -4.48455379412262 0.00149155200072234 MirTarget;mirMAP -0.28989018336422 0.00626092588038326 NA NA NA hsa-miR-486-5p IGF1 1.10898145177457 0.309287974401609 -4.48455379412262 0.00149155200072234 PITA;miRNATAP -0.349556791581636 1.58501267453983e-06 NA NA NA hsa-miR-576-5p IGF1 1.30320223793746 0.00648929463912994 -4.48455379412262 0.00149155200072234 PITA;mirMAP;miRNATAP -0.686331142925331 4.29578185739691e-05 NA NA NA hsa-miR-629-5p IGF1 1.57164125641392 0.0115716388531198 -4.48455379412262 0.00149155200072234 mirMAP -0.4282336374449 0.000902416424835987 NA NA NA hsa-miR-940 IGF1 3.78496690968119 4.75227557809023e-05 -4.48455379412262 0.00149155200072234 MirTarget;PITA;miRNATAP -0.340594099196604 0.00112659190128122 NA NA NA hsa-miR-148b-3p MAPK1 1.75622244535669 8.84414356040579e-08 0.0128019530419543 0.96439785606773 mirMAP -0.139901367015828 0.00442278516722453 NA NA NA hsa-miR-29b-2-5p MAPK1 -0.596051745078872 0.189540844841389 0.0128019530419543 0.96439785606773 mirMAP -0.150888486209755 2.15475742904008e-05 NA NA NA hsa-miR-29c-3p MAPK1 -0.414153610337085 0.529344128062017 0.0128019530419543 0.96439785606773 mirMAP -0.121961986993 4.61168241690927e-07 NA NA NA hsa-miR-30b-5p MAPK1 0.0238659735605804 0.953223658270319 0.0128019530419543 0.96439785606773 mirMAP -0.107494044816223 0.00753809874561411 NA NA NA hsa-miR-30e-5p MAPK1 0.780047227271616 0.0346714425913016 0.0128019530419543 0.96439785606773 mirMAP -0.116090988644527 0.00885887810727849 NA NA NA hsa-miR-3913-5p MAPK1 0.145645056779437 0.734844256690741 0.0128019530419543 0.96439785606773 mirMAP -0.108088444698366 0.00439552964093496 NA NA NA hsa-miR-2355-5p PDPK1 0.418226038913005 0.502149040287915 0.306582564392546 0.475941655495172 mirMAP -0.103108226134942 0.00842031347464144 NA NA NA hsa-miR-331-3p PDPK1 2.60769294751513 3.84318952029483e-07 0.306582564392546 0.475941655495172 miRNAWalker2_validate -0.121492218481836 0.00927780113542185 NA NA NA hsa-miR-335-5p PDPK1 0.167216045757305 0.803897055331049 0.306582564392546 0.475941655495172 mirMAP -0.119757895953739 0.000897643278107525 NA NA NA hsa-miR-374a-3p PDPK1 0.465360399099794 0.305267458251279 0.306582564392546 0.475941655495172 mirMAP -0.230622538416318 1.68353183571966e-05 NA NA NA hsa-miR-374b-5p PDPK1 -0.114749866169918 0.764888930049438 0.306582564392546 0.475941655495172 miRNATAP -0.196301486044882 0.00227955878743118 NA NA NA hsa-miR-424-5p PDPK1 0.209571188331903 0.753714747345068 0.306582564392546 0.475941655495172 mirMAP -0.107328960543962 0.00321761385868636 NA NA NA hsa-miR-505-3p PDPK1 0.58881333170866 0.226937454637888 0.306582564392546 0.475941655495172 mirMAP -0.160675222484928 0.00135084804850823 NA NA NA hsa-miR-590-3p PDPK1 2.35429565068338 2.79601879608564e-06 0.306582564392546 0.475941655495172 miRanda;miRNATAP -0.153973762930792 0.00126758596013474 NA NA NA hsa-miR-7-1-3p PDPK1 1.43074343339835 0.00471215970502094 0.306582564392546 0.475941655495172 mirMAP -0.167155439005958 0.000480585137518429 NA NA NA hsa-miR-708-3p PDPK1 0.781444321399141 0.290645825716608 0.306582564392546 0.475941655495172 miRNATAP -0.102610127578191 0.00176122802875978 NA NA NA hsa-miR-34a-5p PGF 0.830377770217786 0.0477544831885907 0.0255711984152289 0.97888604472598 miRNATAP -0.469702846148815 0.00034617557544533 NA NA NA hsa-miR-429 PGF 6.39965293994036 1.96920201593608e-18 0.0255711984152289 0.97888604472598 miRNATAP -0.260855037574621 0.000203354450361377 NA NA NA hsa-miR-148b-3p PIK3CA 1.75622244535669 8.84414356040579e-08 0.514328426212782 0.248930105421785 miRNAWalker2_validate -0.244141801200414 0.00147579635788138 NA NA NA hsa-miR-186-5p PIK3CA 0.445443449112564 0.185447310527704 0.514328426212782 0.248930105421785 mirMAP -0.280960133798979 0.000232701716483115 NA NA NA hsa-miR-29b-1-5p PIK3CA 0.33698032160171 0.598092174563471 0.514328426212782 0.248930105421785 mirMAP -0.12089066483943 0.00233700941849917 NA NA NA hsa-miR-320b PIK3CA 0.20205459771295 0.727216419960509 0.514328426212782 0.248930105421785 miRanda -0.121444800770151 0.00550932456475504 NA NA NA hsa-miR-335-5p PIK3CA 0.167216045757305 0.803897055331049 0.514328426212782 0.248930105421785 miRNAWalker2_validate -0.124494566731403 0.000883627732385134 NA NA NA hsa-miR-338-5p PIK3CA -0.108304629897487 0.894675560494607 0.514328426212782 0.248930105421785 mirMAP -0.108048495334147 0.00046563589386498 NA NA NA hsa-miR-339-5p PIK3CA 1.23326828594484 0.0307501214818698 0.514328426212782 0.248930105421785 miRanda -0.13798173006655 0.00178425799549926 NA NA NA hsa-miR-501-5p PIK3CA 1.0411896821345 0.0777206709183552 0.514328426212782 0.248930105421785 mirMAP -0.120904681333791 0.00473986403400753 NA NA NA hsa-miR-130a-3p PIK3CB 0.176861046122832 0.7577473016872 0.897158330473952 0.0125840363244796 miRNATAP -0.116582529549782 0.00106378240800672 NA NA NA hsa-miR-19b-3p PIK3CB 1.67581705793313 0.000858910586302716 0.897158330473952 0.0125840363244796 miRNATAP -0.110401307134748 0.00639042894521705 NA NA NA hsa-miR-1468-5p PIK3CD -1.63442718498426 0.00779372976116312 0.0551399776366237 0.926564879247674 MirTarget -0.153354934509346 0.00559561965869134 NA NA NA hsa-miR-199a-5p PIK3CD -1.24888110793613 0.0747755616523728 0.0551399776366237 0.926564879247674 MirTarget;PITA;miRanda;miRNATAP -0.160352223725155 0.000860262558034989 NA NA NA hsa-miR-30d-5p PIK3CD 0.302504510257496 0.380193536606962 0.0551399776366237 0.926564879247674 MirTarget;miRNATAP -0.269704587228763 0.00722775970426478 NA NA NA hsa-miR-3913-5p PIK3CD 0.145645056779437 0.734844256690741 0.0551399776366237 0.926564879247674 mirMAP -0.258109601835399 0.00117084989668902 NA NA NA hsa-miR-335-3p PIK3CG 1.19503568251824 0.0938852560631551 -0.156343505309127 0.848670326900117 mirMAP -0.289128547018831 6.98940085423769e-06 NA NA NA hsa-miR-16-2-3p PIK3R1 3.79845098071094 1.49120139344659e-13 -1.85375256159008 0.0127438113463991 MirTarget -0.220421111740374 0.0054973163518176 NA NA NA hsa-miR-16-5p PIK3R1 2.93575808220754 2.15436817162977e-10 -1.85375256159008 0.0127438113463991 MirTarget -0.232718839097215 0.0094069232214411 NA NA NA hsa-miR-17-5p PIK3R1 2.3269271449522 2.13987445663942e-05 -1.85375256159008 0.0127438113463991 MirTarget;TargetScan;miRNATAP -0.263550021803503 0.000561403048031031 NA NA NA hsa-miR-200c-3p PIK3R1 6.47012025883743 2.64500707716408e-26 -1.85375256159008 0.0127438113463991 mirMAP -0.209884750055895 0.000971059963262446 NA NA NA hsa-miR-29b-3p PIK3R1 0.666547117072858 0.234055379278093 -1.85375256159008 0.0127438113463991 MirTarget;miRNATAP -0.229458801110313 0.00247922380727846 NA NA NA hsa-miR-3065-5p PIK3R1 2.14185373842821 0.0609400502269891 -1.85375256159008 0.0127438113463991 MirTarget;mirMAP;miRNATAP -0.136442762182432 0.00300321263691178 NA NA NA hsa-miR-320c PIK3R1 -0.10618808730545 0.854002814666472 -1.85375256159008 0.0127438113463991 miRNATAP -0.237528056213487 0.00153215444016214 NA NA NA hsa-miR-330-3p PIK3R1 2.49094236945806 0.000129367003214715 -1.85375256159008 0.0127438113463991 MirTarget;PITA;miRNATAP -0.222421511130143 0.000560333266659095 NA NA NA hsa-miR-335-3p PIK3R1 1.19503568251824 0.0938852560631551 -1.85375256159008 0.0127438113463991 mirMAP -0.187424798668302 0.00154671007013318 NA NA NA hsa-miR-338-5p PIK3R1 -0.108304629897487 0.894675560494607 -1.85375256159008 0.0127438113463991 PITA -0.149038254580324 0.00415133065382571 NA NA NA hsa-miR-582-5p PIK3R1 0.685177900016753 0.447761540297692 -1.85375256159008 0.0127438113463991 mirMAP -0.168928206892885 0.000293205730117536 NA NA NA hsa-miR-584-5p PIK3R1 1.17912816682866 0.202862496863776 -1.85375256159008 0.0127438113463991 mirMAP -0.264485629334745 3.0909574049315e-09 NA NA NA hsa-miR-590-5p PIK3R1 1.51400888103768 0.0023888567923017 -1.85375256159008 0.0127438113463991 MirTarget;PITA;miRanda;miRNATAP -0.297003967343676 0.000452335914243657 NA NA NA hsa-miR-629-3p PIK3R1 3.48282157979573 4.9176538695908e-08 -1.85375256159008 0.0127438113463991 MirTarget -0.21216292379107 0.00105654186835094 NA NA NA hsa-miR-1271-5p PIK3R3 0.212382644103427 0.742544160267329 -0.029728653396571 0.959330193755408 mirMAP -0.151933011438603 0.00299533512999816 NA NA NA hsa-miR-18a-3p PIK3R3 3.64944956993027 7.20156641833731e-07 -0.029728653396571 0.959330193755408 miRNAWalker2_validate -0.172437749406846 8.76134189601592e-05 NA NA NA hsa-miR-222-5p PIK3R3 2.52056758362407 0.00142010793166944 -0.029728653396571 0.959330193755408 mirMAP -0.169591357898129 3.80520658072856e-05 NA NA NA hsa-miR-29b-1-5p PIK3R3 0.33698032160171 0.598092174563471 -0.029728653396571 0.959330193755408 mirMAP -0.214703534793861 3.15537480066889e-05 NA NA NA hsa-miR-330-3p PIK3R3 2.49094236945806 0.000129367003214715 -0.029728653396571 0.959330193755408 MirTarget -0.191183653307302 0.000135580399986553 NA NA NA hsa-miR-330-5p PIK3R3 2.25110496739954 0.000275527655397415 -0.029728653396571 0.959330193755408 miRanda -0.158989578902319 0.00262587059425892 NA NA NA hsa-miR-365a-3p PIK3R3 0.25545896241765 0.654320504621012 -0.029728653396571 0.959330193755408 MirTarget -0.330277583325266 6.38384266733533e-09 NA NA NA hsa-miR-511-5p PIK3R3 1.10428503984162 0.179276103915417 -0.029728653396571 0.959330193755408 MirTarget -0.179185145111208 6.38466351145281e-06 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-590-5p PIK3R3 1.51400888103768 0.0023888567923017 -0.029728653396571 0.959330193755408 miRanda -0.195493025557274 0.00311783468590026 NA NA NA hsa-miR-125a-3p PIK3R5 -0.0748960586927341 0.920735897434087 0.75811064163987 0.286920846128457 miRanda -0.143772140191083 0.00747323319002246 NA NA NA hsa-miR-125a-5p PIK3R5 -1.32352790615388 0.00714301627309467 0.75811064163987 0.286920846128457 MirTarget;miRanda -0.250957855170204 0.00223286885929377 NA NA NA hsa-miR-182-5p PIK3R5 5.86988712704738 1.22411588571584e-15 0.75811064163987 0.286920846128457 MirTarget -0.25329203027594 9.2894340160784e-07 NA NA NA hsa-miR-19a-3p PRKAA1 2.17020503944519 0.00122084653711062 -0.14272062956041 0.708457800162383 miRNATAP -0.121877936085399 0.000121351742732488 NA NA NA hsa-miR-19b-3p PRKAA1 1.67581705793313 0.000858910586302716 -0.14272062956041 0.708457800162383 miRNAWalker2_validate;miRTarBase;miRNATAP -0.1436893824791 0.000755247351571621 NA NA NA hsa-miR-590-3p PRKAA1 2.35429565068338 2.79601879608564e-06 -0.14272062956041 0.708457800162383 MirTarget;miRanda;mirMAP -0.159819133040541 0.000152519009478064 NA NA NA hsa-miR-590-5p PRKAA1 1.51400888103768 0.0023888567923017 -0.14272062956041 0.708457800162383 miRanda -0.127622456320397 0.00312575183340519 NA NA NA hsa-miR-142-5p PRKAA2 3.95552531913424 1.49536283724079e-08 -1.64186892044043 0.304588246308584 mirMAP -0.733679899144415 3.28129434658743e-09 NA NA NA hsa-miR-146a-5p PRKAA2 2.64646698525354 0.000280611928973036 -1.64186892044043 0.304588246308584 MirTarget -0.510281421549701 3.0466836944546e-05 NA NA NA hsa-miR-146b-5p PRKAA2 1.87569569182453 0.000737241069698886 -1.64186892044043 0.304588246308584 MirTarget -0.677636044535875 2.66207392598239e-05 NA NA NA hsa-miR-150-3p PRKAA2 1.65258591448117 0.058477568382345 -1.64186892044043 0.304588246308584 MirTarget;miRNATAP -0.563781561577572 7.53911077950056e-08 NA NA NA hsa-miR-203a-3p PRKAA2 6.35084246337388 7.89944323347948e-08 -1.64186892044043 0.304588246308584 MirTarget -0.432436265326421 3.35611293563868e-09 NA NA NA hsa-miR-22-5p PRKAA2 2.38337850108621 1.0773503998394e-05 -1.64186892044043 0.304588246308584 mirMAP -0.470263121239052 0.00457421554834218 NA NA NA hsa-miR-23a-3p PRKAA2 0.925125296618358 0.0127293543936914 -1.64186892044043 0.304588246308584 mirMAP -0.71119737453032 0.00405550837945771 NA NA NA hsa-miR-27b-5p PRKAA2 0.213392605793392 0.71562473353293 -1.64186892044043 0.304588246308584 MirTarget;miRNATAP -0.60817407358398 8.32905119807132e-05 NA NA NA hsa-miR-342-3p PRKAA2 1.31107714473009 0.0207211910724662 -1.64186892044043 0.304588246308584 PITA -1.02655657966323 4.19058043429419e-11 NA NA NA hsa-miR-34c-3p PRKAA2 4.0411891981675 0.000195495966405666 -1.64186892044043 0.304588246308584 PITA -0.348300367275928 2.34411683541998e-05 NA NA NA hsa-miR-34c-5p PRKAA2 2.64675661251039 0.0157394735757952 -1.64186892044043 0.304588246308584 miRNATAP -0.346761506200615 2.1638696771148e-05 NA NA NA hsa-miR-590-3p PRKAA2 2.35429565068338 2.79601879608564e-06 -1.64186892044043 0.304588246308584 mirMAP;miRNATAP -0.47594243821822 0.00777370830247716 NA NA NA hsa-miR-944 PRKAA2 7.20925181386398 0.000823207457340648 -1.64186892044043 0.304588246308584 mirMAP -0.379896831337975 2.22682094114287e-14 NA NA NA hsa-miR-15b-3p RICTOR 3.57530146629867 5.89922785773482e-11 -0.245151891102313 0.522334062834239 mirMAP -0.11740177171332 0.00224919531203597 NA NA NA hsa-miR-16-1-3p RICTOR 2.83281226969693 7.54359864580834e-09 -0.245151891102313 0.522334062834239 MirTarget -0.140860525900497 0.00111056845182421 NA NA NA hsa-miR-188-5p RICTOR 1.39111178824125 0.0251592818948912 -0.245151891102313 0.522334062834239 MirTarget;PITA;miRNATAP -0.113436557582237 0.00114377309629276 NA NA NA hsa-miR-26b-3p RICTOR 0.985177548213122 0.0351427970185971 -0.245151891102313 0.522334062834239 MirTarget -0.140410757088931 0.00252166122507131 NA NA NA hsa-miR-590-3p RICTOR 2.35429565068338 2.79601879608564e-06 -0.245151891102313 0.522334062834239 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.118472016725884 0.00542901063543767 NA NA NA hsa-miR-660-5p RICTOR -0.0668683798854808 0.885250178390404 -0.245151891102313 0.522334062834239 MirTarget -0.198510445302814 2.18207380719342e-05 NA NA NA hsa-miR-1271-5p RPS6KA2 0.212382644103427 0.742544160267329 -2.65030014005572 0.000604235142902453 mirMAP -0.205729695165376 0.00268820251345792 NA NA NA hsa-miR-17-5p RPS6KA2 2.3269271449522 2.13987445663942e-05 -2.65030014005572 0.000604235142902453 TargetScan -0.277716691933536 0.000491109025542043 NA NA NA hsa-miR-193a-3p RPS6KA2 0.646392169474854 0.207134343676122 -2.65030014005572 0.000604235142902453 mirMAP -0.243071120724014 0.00506444605891364 NA NA NA hsa-miR-19b-3p RPS6KA2 1.67581705793313 0.000858910586302716 -2.65030014005572 0.000604235142902453 MirTarget -0.275239570627294 0.00167663626230614 NA NA NA hsa-miR-200c-3p RPS6KA2 6.47012025883743 2.64500707716408e-26 -2.65030014005572 0.000604235142902453 miRNATAP -0.185226101150327 0.005371700638205 NA NA NA hsa-miR-30e-5p RPS6KA2 0.780047227271616 0.0346714425913016 -2.65030014005572 0.000604235142902453 MirTarget -0.487113159267505 5.36366592420531e-05 NA NA NA hsa-miR-378a-3p RPS6KA2 1.46612141870273 0.0466660641196872 -2.65030014005572 0.000604235142902453 MirTarget -0.251494688876595 2.23223122446489e-05 NA NA NA hsa-miR-378c RPS6KA2 0.449601775771001 0.4993814483956 -2.65030014005572 0.000604235142902453 MirTarget -0.194068395078508 0.00355016245964441 NA NA NA hsa-miR-9-3p RPS6KA2 1.69328215716742 0.125170982657059 -2.65030014005572 0.000604235142902453 MirTarget -0.173109404251115 1.61584766530112e-05 NA NA NA hsa-miR-9-5p RPS6KA2 1.79620806707734 0.14526963042518 -2.65030014005572 0.000604235142902453 miRNATAP -0.179360056481064 3.30496459020001e-07 NA NA NA hsa-miR-141-3p RPS6KA6 7.30474126597325 1.45115996357606e-24 -4.01589146007697 0.00361422176832556 MirTarget -0.30702156340192 0.00250736247952691 NA NA NA hsa-miR-15b-5p RPS6KA6 3.32329949959268 8.40210501034588e-13 -4.01589146007697 0.00361422176832556 MirTarget -0.630779583352634 0.000112057448754317 NA NA NA hsa-miR-16-5p RPS6KA6 2.93575808220754 2.15436817162977e-10 -4.01589146007697 0.00361422176832556 MirTarget -0.757078300034172 4.28813440897308e-06 NA NA NA hsa-miR-17-5p RPS6KA6 2.3269271449522 2.13987445663942e-05 -4.01589146007697 0.00361422176832556 TargetScan -0.429125605520815 0.00257843057134291 NA NA NA hsa-miR-19b-3p RPS6KA6 1.67581705793313 0.000858910586302716 -4.01589146007697 0.00361422176832556 MirTarget -0.408003865579579 0.00914510270200835 NA NA NA hsa-miR-20a-3p RPS6KA6 1.9920766549842 0.000624458530894697 -4.01589146007697 0.00361422176832556 MirTarget -0.367180983126307 0.00636307573029767 NA NA NA hsa-miR-107 RPS6KB1 1.49443409571439 0.000130594521065411 0.147277461109991 0.600506468158798 PITA;miRanda -0.111469431880308 0.00608626394063609 NA NA NA hsa-miR-186-5p RPS6KB1 0.445443449112564 0.185447310527704 0.147277461109991 0.600506468158798 MirTarget;miRNATAP -0.188202471127657 8.10651969496359e-05 NA NA NA hsa-miR-125a-5p RPS6KB2 -1.32352790615388 0.00714301627309467 0.879028619054892 0.0118268028070626 miRanda -0.169895564703728 2.13927288529754e-05 NA NA NA hsa-miR-330-3p STK11 2.49094236945806 0.000129367003214715 -0.26276893218333 0.64145996974596 mirMAP -0.180754893902168 0.000195158543898518 NA NA NA hsa-miR-330-5p STK11 2.25110496739954 0.000275527655397415 -0.26276893218333 0.64145996974596 miRanda -0.228906258010212 6.30285088801753e-06 NA NA NA hsa-miR-186-5p STRADA 0.445443449112564 0.185447310527704 -0.229766308318079 0.397238663370525 mirMAP -0.121596994850888 0.00876934553024345 NA NA NA hsa-miR-28-3p TSC1 -0.992446114847535 0.0188188359018203 -0.164264744382803 0.558456176869371 PITA -0.163451002258092 1.1903394911001e-05 NA NA NA hsa-miR-29a-5p TSC1 0.0748295222568571 0.884125894063293 -0.164264744382803 0.558456176869371 mirMAP -0.105441022835942 0.000632720914912164 NA NA NA hsa-miR-320b ULK1 0.20205459771295 0.727216419960509 -0.266708882363476 0.443031293812383 miRNATAP -0.108910810166154 0.00132925139550834 NA NA NA hsa-miR-338-5p ULK1 -0.108304629897487 0.894675560494607 -0.266708882363476 0.443031293812383 PITA -0.112202073160501 2.4272733560777e-06 NA NA NA hsa-miR-92b-3p ULK1 1.69303761469782 0.0103484911955574 -0.266708882363476 0.443031293812383 miRNATAP -0.113736844338434 0.000111525465678901 NA NA NA hsa-let-7f-1-3p ULK2 1.61507869803314 0.00069342464777815 -0.929270538277041 0.0276534978763457 MirTarget -0.169070136832637 0.000783570124708853 NA NA NA hsa-miR-223-3p ULK2 2.27436751816553 0.00779697425178179 -0.929270538277041 0.0276534978763457 MirTarget -0.110637001615717 6.20860268153876e-05 NA NA NA hsa-miR-590-3p ULK2 2.35429565068338 2.79601879608564e-06 -0.929270538277041 0.0276534978763457 mirMAP -0.131449068842525 0.0052852077242265 NA NA NA hsa-miR-101-3p VEGFA -1.12421603598195 0.0200907284788457 -0.606702191559893 0.316325541201332 miRNAWalker2_validate -0.44049017437003 2.14988554587478e-10 NA NA NA hsa-miR-140-5p VEGFA -0.634610285725923 0.126670572966239 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.25107167892515 0.00261330338296037 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-145-5p VEGFA -3.55505374822025 5.45525288912869e-07 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase -0.128423755259373 0.00677881518234136 24781864;24966896;22472569 Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically metastasis;; thyroid cancer;bladder cancer;sarcoma hsa-miR-150-5p VEGFA 1.76769157530064 0.0593795975117846 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase -0.190454559321715 1.05415152205695e-07 NA NA NA hsa-miR-195-5p VEGFA -1.59182537400701 0.0169128463756769 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase;MirTarget -0.181624543409355 0.000381561947949573 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA -1.24888110793613 0.0747755616523728 -0.606702191559893 0.316325541201332 miRanda;miRNATAP -0.137846678781097 0.00478526288616186 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA -0.53728867775768 0.476885702455766 -0.606702191559893 0.316325541201332 miRanda -0.179432408970336 6.95568617152433e-05 NA NA NA hsa-miR-29a-3p VEGFA -0.638239697975974 0.251923581881716 -0.606702191559893 0.316325541201332 MirTarget -0.17079026405468 0.00573296636369365 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29b-2-5p VEGFA -0.596051745078872 0.189540844841389 -0.606702191559893 0.316325541201332 MirTarget -0.280821422267245 0.000211600516233879 NA NA NA hsa-miR-29b-3p VEGFA 0.666547117072858 0.234055379278093 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase;MirTarget -0.16053544503029 0.00905921871447091 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-29c-3p VEGFA -0.414153610337085 0.529344128062017 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;MirTarget -0.264648504422189 2.62132710063096e-07 NA NA NA hsa-miR-342-3p VEGFA 1.31107714473009 0.0207211910724662 -0.606702191559893 0.316325541201332 miRanda;miRNATAP -0.189890193502324 0.00167517321250592 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-497-5p VEGFA -1.44150596209372 0.0225146607606395 -0.606702191559893 0.316325541201332 MirTarget -0.20501977308518 0.000143045715274148 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer hsa-miR-16-2-3p VEGFC 3.79845098071094 1.49120139344659e-13 -2.61199123014623 0.00786293959867815 MirTarget -0.523426860787708 4.20594096318382e-07 NA NA NA