miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-3p ABCA1 0.101609552389411 0.646619196813319 -0.0451076055399273 0.83080167835203 mirMAP;miRNATAP -0.394383684923022 1.77995786346008e-07 NA NA NA hsa-let-7a-3p ABCC9 0.101609552389411 0.646619196813319 -0.581756315289933 0.0486956279031877 mirMAP -0.796613815830176 1.97147188651006e-12 NA NA NA hsa-let-7a-3p ABCD2 0.101609552389411 0.646619196813319 -0.208004994484089 0.523593130565674 mirMAP -0.513737031086163 4.54162334876976e-05 NA NA NA hsa-let-7a-3p ABI3BP 0.101609552389411 0.646619196813319 -0.518455253281744 0.156674806137791 miRNATAP -0.620967300885678 1.88010351647496e-05 NA NA NA hsa-let-7a-3p ACVR1 0.101609552389411 0.646619196813319 0.0136535982300794 0.920989557619491 MirTarget;miRNATAP -0.117231784088334 0.000243196209904912 NA NA NA hsa-let-7a-3p ADAM23 0.101609552389411 0.646619196813319 -0.789446988740113 0.0354908375160658 mirMAP -0.964187841730036 1.80257849942225e-11 NA NA NA hsa-let-7a-3p ADAMTS5 0.101609552389411 0.646619196813319 -0.214097632705149 0.263966043901743 mirMAP -0.356905380272848 5.05628652022576e-07 NA NA NA hsa-let-7a-3p ADAMTSL3 0.101609552389411 0.646619196813319 -0.463052703910348 0.25267439345332 MirTarget -1.13837970040903 1.17619893382785e-13 NA NA NA hsa-let-7a-3p ADCYAP1 0.101609552389411 0.646619196813319 -0.200731583844237 0.671848784723094 miRNATAP -1.11740690500738 7.77041027107581e-10 NA NA NA hsa-let-7a-3p ADD2 0.101609552389411 0.646619196813319 -0.982457516719064 0.0173527762952039 mirMAP -0.741173835817103 3.07352298879595e-06 NA NA NA hsa-let-7a-3p AFF2 0.101609552389411 0.646619196813319 -0.19438797794071 0.587217094586229 mirMAP -0.35130037178478 0.0119966997802438 NA NA NA hsa-let-7a-3p AFF3 0.101609552389411 0.646619196813319 -0.89210425092024 0.00695939321475151 MirTarget -0.459326001830164 0.000481519431358232 NA NA NA hsa-let-7a-3p AKAP12 0.101609552389411 0.646619196813319 -0.668187649412717 0.0515748917148181 miRNATAP -0.88403230439673 7.40686178733717e-12 NA NA NA hsa-miR-106a-5p AKT3 0.542051091047854 0.00782852255091914 -0.591284086515014 0.0164134975775705 miRNATAP -0.549479065869633 4.88994896864722e-11 NA NA NA hsa-miR-106b-5p AKT3 0.284551111571426 0.277367924981826 -0.591284086515014 0.0164134975775705 miRNATAP -0.910251258276316 1.51432008761514e-23 NA NA NA hsa-miR-107 AKT3 0.0279960669519728 0.920212407969573 -0.591284086515014 0.0164134975775705 PITA;miRanda -0.551086378595188 0.000172037624489873 NA NA NA hsa-miR-1275 AKT3 0.826421555845947 0.00690634946385774 -0.591284086515014 0.0164134975775705 PITA -0.265795172887599 9.47325565176386e-07 NA NA NA hsa-miR-140-5p AKT3 0.0587198104089381 0.763206723501799 -0.591284086515014 0.0164134975775705 miRanda -0.293235686594899 0.0229652780617548 NA NA NA hsa-miR-142-3p AKT3 0.138202987615315 0.672554936747315 -0.591284086515014 0.0164134975775705 miRanda -0.196043223886578 0.00627089530211866 NA NA NA hsa-miR-15a-5p AKT3 0.211823319622055 0.34754443857672 -0.591284086515014 0.0164134975775705 miRNAWalker2_validate;miRTarBase;miRNATAP -0.721206491484116 7.61586942839311e-13 NA NA NA hsa-miR-15b-5p AKT3 0.101141961851801 0.680859173657598 -0.591284086515014 0.0164134975775705 miRNATAP -0.665977383717092 1.97063059627596e-12 NA NA NA hsa-miR-16-5p AKT3 0.145487293472948 0.590284028672631 -0.591284086515014 0.0164134975775705 miRNAWalker2_validate;miRTarBase;miRNATAP -0.746124766270904 9.10401236853758e-16 NA NA NA hsa-miR-17-3p AKT3 0.426443192002077 0.112120696281136 -0.591284086515014 0.0164134975775705 miRNATAP -0.519758313376015 2.03997342351785e-09 NA NA NA hsa-miR-17-5p AKT3 0.654454113630718 0.0320922529414325 -0.591284086515014 0.0164134975775705 TargetScan;miRNATAP -0.626536048377156 1.11076874125702e-18 NA NA NA hsa-miR-181b-5p AKT3 0.114077927538188 0.649177797934569 -0.591284086515014 0.0164134975775705 miRNATAP -0.268064668813324 0.00963449049657038 NA NA NA hsa-miR-20a-5p AKT3 0.575987288988369 0.0504195522708827 -0.591284086515014 0.0164134975775705 miRNATAP -0.531063551395964 1.32783278364081e-13 NA NA NA hsa-miR-28-3p AKT3 -0.00585351979002091 0.984381267192792 -0.591284086515014 0.0164134975775705 miRNATAP -0.521845591393563 0.00718630427898147 NA NA NA hsa-miR-29a-3p AKT3 0.422455884388283 0.210846507695107 -0.591284086515014 0.0164134975775705 miRNATAP -0.812359982380835 1.03842433672581e-13 NA NA NA hsa-miR-29b-3p AKT3 0.576937416051043 0.0425757132324386 -0.591284086515014 0.0164134975775705 miRNATAP -0.677276652111253 9.58518141369729e-17 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-32-3p AKT3 0.331827826560311 0.224850265700549 -0.591284086515014 0.0164134975775705 mirMAP -0.563455040593992 1.29815959529041e-22 NA NA NA hsa-miR-320a AKT3 0.0445132408352098 0.868835492785552 -0.591284086515014 0.0164134975775705 PITA;miRanda;miRNATAP -0.333446337886203 0.00137735387479576 NA NA NA hsa-miR-320b AKT3 0.0476110968391366 0.835429263750272 -0.591284086515014 0.0164134975775705 PITA;miRanda;miRNATAP -0.247020375326149 0.00854841822062789 NA NA NA hsa-miR-320c AKT3 0.128690462181369 0.61007863583614 -0.591284086515014 0.0164134975775705 PITA;miRanda;miRNATAP -0.168706913972951 0.0152504739210101 NA NA NA hsa-miR-335-3p AKT3 0.682801908222203 0.00891090859328538 -0.591284086515014 0.0164134975775705 mirMAP -0.579661626156677 1.71660731221086e-14 NA NA NA hsa-miR-33a-3p AKT3 0.0801132536031662 0.726683004542423 -0.591284086515014 0.0164134975775705 mirMAP -0.48908545949649 5.69174183767199e-12 NA NA NA hsa-miR-340-5p AKT3 0.0370561016519786 0.847255543644633 -0.591284086515014 0.0164134975775705 mirMAP -0.282303409119482 0.00600476945925659 NA NA NA hsa-miR-362-3p AKT3 0.110321687543857 0.643792555636786 -0.591284086515014 0.0164134975775705 miRanda -0.415414242264488 1.82625494243827e-09 NA NA NA hsa-miR-362-5p AKT3 0.506367125681149 0.0511376993060576 -0.591284086515014 0.0164134975775705 PITA;TargetScan;miRNATAP -0.516617267683569 4.2053666241316e-16 NA NA NA hsa-miR-369-3p AKT3 0.135995136901538 0.499460414151147 -0.591284086515014 0.0164134975775705 mirMAP -0.2347933374382 0.00901179401751285 NA NA NA hsa-miR-374a-5p AKT3 0.319715396296898 0.0770941358748204 -0.591284086515014 0.0164134975775705 mirMAP -0.579942468779622 2.643062323348e-06 NA NA NA hsa-miR-374b-5p AKT3 0.420828077578832 0.0368215896674663 -0.591284086515014 0.0164134975775705 mirMAP -0.684416910019692 6.98155817205318e-09 NA NA NA hsa-miR-421 AKT3 0.483846282376657 0.0175641163246583 -0.591284086515014 0.0164134975775705 miRanda;mirMAP -0.463766741666901 1.36843495165118e-08 NA NA NA hsa-miR-424-5p AKT3 0.362472054054227 0.208698146989944 -0.591284086515014 0.0164134975775705 miRNATAP -0.239499066096292 0.00104453067376223 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth liver cancer hsa-miR-501-3p AKT3 0.234292195069095 0.341151928657571 -0.591284086515014 0.0164134975775705 miRNATAP -0.497935902986368 2.06014814106823e-10 NA NA NA hsa-miR-502-3p AKT3 0.215827408176194 0.267723766493589 -0.591284086515014 0.0164134975775705 miRNATAP -0.644160673294049 1.58962279838432e-12 NA NA NA hsa-miR-502-5p AKT3 0.0640287093715612 0.786573915467216 -0.591284086515014 0.0164134975775705 PITA;miRNATAP -0.409328372897747 4.31887851181114e-09 NA NA NA hsa-miR-505-3p AKT3 0.314361037806565 0.127920046999512 -0.591284086515014 0.0164134975775705 mirMAP -0.774927841273818 6.77311058531751e-15 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-539-5p AKT3 0.259593033966436 0.160500597685709 -0.591284086515014 0.0164134975775705 mirMAP;miRNATAP -0.192395187722177 0.046702748153238 NA NA NA hsa-miR-548o-3p AKT3 0.287494379071396 0.191813664384868 -0.591284086515014 0.0164134975775705 mirMAP -0.314174287829114 7.58105126731538e-05 NA NA NA hsa-miR-577 AKT3 -0.131565620416609 0.724256245908512 -0.591284086515014 0.0164134975775705 mirMAP -0.383091519653111 6.42065724452006e-20 NA NA NA hsa-miR-663b AKT3 0.416718349802096 0.176799757690699 -0.591284086515014 0.0164134975775705 PITA -0.247711064601903 1.07528758067609e-05 NA NA NA hsa-miR-769-5p AKT3 0.351503073928425 0.0459226128816148 -0.591284086515014 0.0164134975775705 PITA;miRNATAP -0.8409977584726 1.11686042031466e-14 NA NA NA hsa-miR-93-5p AKT3 0.240698477893627 0.478488479349248 -0.591284086515014 0.0164134975775705 miRNATAP -0.762020096686085 6.75211862260925e-18 NA NA NA hsa-let-7a-3p ALDH1L2 0.101609552389411 0.646619196813319 0.0456163211514098 0.871169135740043 MirTarget -0.496138863624185 3.79571907568601e-06 NA NA NA hsa-let-7a-3p AMIGO2 0.101609552389411 0.646619196813319 -0.383259617713045 0.132717159132885 MirTarget;mirMAP -0.389911459303788 4.87417185737882e-05 NA NA NA hsa-let-7a-3p AMOTL1 0.101609552389411 0.646619196813319 -0.755717609683826 0.00615452172220113 mirMAP -0.641446459128087 1.2129988456844e-09 NA NA NA hsa-let-7a-3p ANKRD50 0.101609552389411 0.646619196813319 -0.0277118042889466 0.857765139457011 mirMAP -0.185095743631623 4.16567134094576e-05 NA NA NA hsa-let-7a-3p ANO5 0.101609552389411 0.646619196813319 -0.634491138597413 0.195212293596687 mirMAP -0.585547307586012 0.0025638432261358 NA NA NA hsa-let-7a-3p ANTXR1 0.101609552389411 0.646619196813319 -0.669053066527898 0.0447872461532967 mirMAP;miRNATAP -0.790155001239989 3.73942026614096e-11 NA NA NA hsa-let-7a-3p AQP9 0.101609552389411 0.646619196813319 -0.943868177482741 0.0440989713492612 MirTarget -0.887862994777131 1.57507476611909e-06 NA NA NA hsa-let-7a-3p ARHGAP20 0.101609552389411 0.646619196813319 -0.996141861596954 0.00161742367245623 MirTarget;miRNATAP -0.605518487037414 9.70256361522864e-07 NA NA NA hsa-let-7a-3p ARHGAP28 0.101609552389411 0.646619196813319 -0.238243385655056 0.373387853316728 mirMAP -0.388117928306008 0.000254804873304825 NA NA NA hsa-let-7a-3p ARHGAP29 0.101609552389411 0.646619196813319 -0.14364560780223 0.480420815495518 mirMAP -0.265428410890195 0.000254888368223575 NA NA NA hsa-let-7a-3p ARL10 0.101609552389411 0.646619196813319 -0.126871042021234 0.631882158361632 mirMAP -0.549585114986142 4.92971421535688e-08 NA NA NA hsa-let-7a-3p ARSB 0.101609552389411 0.646619196813319 -0.605263932662853 0.000198784028322665 mirMAP -0.165675897686895 0.00257868692894442 NA NA NA hsa-let-7a-3p ASAH1 0.101609552389411 0.646619196813319 -0.21888661522447 0.2428139504747 MirTarget -0.13951925242809 0.00224639347907709 NA NA NA hsa-let-7a-3p ASAP1 0.101609552389411 0.646619196813319 0.156253385091605 0.366898098169787 mirMAP -0.187881190162935 0.000595770723275848 NA NA NA hsa-let-7a-3p ASXL2 0.101609552389411 0.646619196813319 -0.00651107258319072 0.968108536124671 mirMAP;miRNATAP -0.176965330744064 0.000809437071089838 NA NA NA hsa-let-7a-3p ATE1 0.101609552389411 0.646619196813319 0.00937720587130153 0.945130228014887 mirMAP -0.13277241632481 0.00264806848344072 NA NA NA hsa-let-7a-3p ATF2 0.101609552389411 0.646619196813319 0.0129927095217646 0.915900621867823 MirTarget;mirMAP;miRNATAP -0.145456257908776 3.85637550129781e-05 NA NA NA hsa-let-7a-3p ATP6AP2 0.101609552389411 0.646619196813319 0.146194411124014 0.444421397774445 mirMAP -0.133226021289561 0.000270371833611246 NA NA NA hsa-let-7a-3p ATRN 0.101609552389411 0.646619196813319 -0.0415214883504804 0.828334812988569 miRNATAP -0.258091788449881 8.40362356608516e-05 NA NA NA hsa-let-7a-3p ATRX 0.101609552389411 0.646619196813319 0.187079701560619 0.227706042741197 MirTarget;miRNATAP -0.130176029418471 0.000506004071240485 NA NA NA hsa-let-7a-3p B3GALNT1 0.101609552389411 0.646619196813319 -0.271118685985781 0.308271917898288 mirMAP -0.371631816187024 0.000311189455579815 NA NA NA hsa-let-7a-3p BAG4 0.101609552389411 0.646619196813319 -0.129971061928048 0.39218107904052 mirMAP -0.200722572872357 0.000210664173605654 NA NA NA hsa-let-7a-3p BASP1 0.101609552389411 0.646619196813319 -0.547509769186107 0.0317360496561156 miRNATAP -0.463601920126025 1.50117173459404e-06 NA NA NA hsa-let-7a-3p BCL6 0.101609552389411 0.646619196813319 -0.429557653860979 0.0206680078657484 miRNATAP -0.16651967562707 0.00802160056137438 NA NA NA hsa-let-7a-3p BDNF 0.101609552389411 0.646619196813319 0.0801897210075031 0.734803833476929 MirTarget;miRNATAP -0.244157318378319 0.00935451173762819 NA NA NA hsa-let-7a-3p BEND4 0.101609552389411 0.646619196813319 -0.574592674112075 0.131575850873596 mirMAP -0.412645488232398 0.00473293101194993 NA NA NA hsa-let-7a-3p BEND6 0.101609552389411 0.646619196813319 -0.572281830762722 0.0655403684969272 mirMAP -0.773159765711536 5.31963427031848e-11 NA NA NA hsa-let-7a-3p BICD2 0.101609552389411 0.646619196813319 -0.0282743734867674 0.845595827766493 mirMAP -0.104107313882164 0.00471573639215664 NA NA NA hsa-let-7a-3p BMP2K 0.101609552389411 0.646619196813319 -0.162745305060747 0.187421099958983 mirMAP -0.165827539788636 6.07822821190309e-05 NA NA NA hsa-let-7a-3p BMP3 0.101609552389411 0.646619196813319 -0.161382424731306 0.77953044546538 MirTarget;mirMAP -0.82259273975373 0.000293324712749253 NA NA NA hsa-let-7a-3p BMPR1B 0.101609552389411 0.646619196813319 -1.561402788789 0.000206654168943301 miRNATAP -0.60946605714919 0.000284017884491797 NA NA NA hsa-let-7a-3p BMPR2 0.101609552389411 0.646619196813319 -0.0768036027341985 0.648738201565609 MirTarget;miRNATAP -0.175468885071709 0.000130019756231136 NA NA NA hsa-let-7a-3p BNC2 0.101609552389411 0.646619196813319 -0.532293160805785 0.0842580878658165 mirMAP -0.769777962431435 8.56711149734912e-11 NA NA NA hsa-miR-146b-5p BRAF -0.172983582782209 0.520789483760829 0.0445938116015294 0.676551926712075 miRanda -0.118645199623624 0.00232493560804849 21874046;26883911;20406109;21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF ;;; thyroid cancer;thyroid cancer;thyroid cancer;thyroid cancer hsa-miR-199a-5p BRAF -0.205348321659653 0.454165162650392 0.0445938116015294 0.676551926712075 miRanda -0.10031453288356 0.00847963162022019 NA NA NA hsa-miR-199b-5p BRAF -0.112113355974747 0.662120164918067 0.0445938116015294 0.676551926712075 miRanda -0.122525543794023 0.00019945402288156 NA NA NA hsa-let-7a-3p BST1 0.101609552389411 0.646619196813319 -0.169734873816886 0.514581402894395 MirTarget -0.381485033338693 0.000238638114856813 NA NA NA hsa-let-7a-3p BTC 0.101609552389411 0.646619196813319 0.159950724204283 0.34141867493924 mirMAP -0.19821343513836 0.0028250929657907 NA NA NA hsa-let-7a-3p BVES 0.101609552389411 0.646619196813319 -0.680308202567824 0.00964552730844623 mirMAP -0.635380857025591 4.74059040682731e-10 NA NA NA hsa-miR-539-5p CAB39 0.259593033966436 0.160500597685709 -0.0642596041243149 0.697563987981332 mirMAP -0.114475231696282 1.104750962654e-05 NA NA NA hsa-miR-155-5p CAB39L -0.0328198973269682 0.903293156597456 0.755500931237831 0.0134270162550669 miRNAWalker2_validate -0.569358116596561 4.43070771861796e-08 NA NA NA hsa-miR-342-3p CAB39L -0.0385072509156021 0.868451741180898 0.755500931237831 0.0134270162550669 miRanda -0.348147849083205 0.00144821023548584 NA NA NA hsa-miR-582-5p CAB39L -0.228254145294111 0.237411325958129 0.755500931237831 0.0134270162550669 miRNATAP -0.682112810028272 1.88859262983573e-09 NA NA NA hsa-miR-590-3p CAB39L 0.61452706068502 0.00851921195946504 0.755500931237831 0.0134270162550669 miRanda -0.333020657288162 0.000205601783804127 NA NA NA hsa-miR-590-5p CAB39L 0.310398056198485 0.187672587496216 0.755500931237831 0.0134270162550669 miRanda -0.223867651416112 0.0194072559378046 NA NA NA hsa-miR-7-1-3p CAB39L -0.0548495194389744 0.804425982450317 0.755500931237831 0.0134270162550669 mirMAP -0.352372997467818 0.000831448863098336 NA NA NA hsa-let-7a-3p CACNA1C 0.101609552389411 0.646619196813319 -0.713981403634655 0.00976076109276503 MirTarget -0.227414575044299 0.0311177968520327 NA NA NA hsa-let-7a-3p CACNA2D1 0.101609552389411 0.646619196813319 -0.851301745677301 0.0557493379505739 mirMAP -1.23589254201515 1.4930895850117e-13 NA NA NA hsa-let-7a-3p CACNG4 0.101609552389411 0.646619196813319 -0.12839481967325 0.843955216114481 MirTarget -0.553741468397336 0.0340462674110164 NA NA NA hsa-let-7a-3p CCDC102B 0.101609552389411 0.646619196813319 -0.356459475266115 0.0694686542324982 MirTarget -0.293272750556617 0.000164877890790506 NA NA NA hsa-let-7a-3p CCDC50 0.101609552389411 0.646619196813319 0.00131845994464541 0.992862628270402 miRNATAP -0.140051504836908 4.07163609496076e-06 NA NA NA hsa-let-7a-3p CCPG1 0.101609552389411 0.646619196813319 -0.390012209596301 0.0262897231582015 mirMAP -0.175144124000326 0.000156610020292179 NA NA NA hsa-let-7a-3p CD109 0.101609552389411 0.646619196813319 -1.08568743085946 0.00327094204952461 mirMAP -0.583208413750158 6.63102420231812e-05 NA NA NA hsa-let-7a-3p CD302 0.101609552389411 0.646619196813319 -0.121728456096513 0.459763249600103 mirMAP -0.169708841551481 0.00115537325166664 NA NA NA hsa-let-7a-3p CD38 0.101609552389411 0.646619196813319 -0.172474239594566 0.67186382478858 MirTarget -0.662973472806657 3.72832939802592e-05 NA NA NA hsa-let-7a-3p CDC14A 0.101609552389411 0.646619196813319 0.231301441270169 0.105601211037448 mirMAP -0.151560721976898 0.00458491367698673 NA NA NA hsa-let-7a-3p CDC42EP3 0.101609552389411 0.646619196813319 -0.0890662100545114 0.61310344122089 MirTarget;mirMAP -0.253735305226449 2.75687575139631e-05 NA NA NA hsa-let-7a-3p CDK17 0.101609552389411 0.646619196813319 -0.174447446020918 0.192076693986441 MirTarget;miRNATAP -0.120856434480799 0.000221105594142108 NA NA NA hsa-let-7a-3p CDS2 0.101609552389411 0.646619196813319 0.22073576641032 0.14006353781938 mirMAP -0.117511440085111 0.00961329526258796 NA NA NA hsa-let-7a-3p CFL2 0.101609552389411 0.646619196813319 -0.324028967097183 0.08550066683466 mirMAP -0.423188855982398 1.4619989682135e-09 NA NA NA hsa-let-7a-3p CHL1 0.101609552389411 0.646619196813319 -0.745798757509799 0.0629667965008125 MirTarget;miRNATAP -0.940270000366059 1.65583490176558e-09 NA NA NA hsa-let-7a-3p CHM 0.101609552389411 0.646619196813319 0.221527239102961 0.125559269421571 MirTarget -0.133378457997774 0.0024619518309959 NA NA NA hsa-let-7a-3p CHST2 0.101609552389411 0.646619196813319 -0.434666274818124 0.0347520942647622 MirTarget -0.301524086892135 0.000198142665526285 NA NA NA hsa-let-7a-3p CLIC4 0.101609552389411 0.646619196813319 -0.292694546315905 0.166828309726868 MirTarget -0.382439466827813 2.65495753349232e-09 NA NA NA hsa-let-7a-3p CLIP1 0.101609552389411 0.646619196813319 -0.119605964220983 0.441766107644993 miRNATAP -0.127206514000832 2.54619217250927e-05 NA NA NA hsa-let-7a-3p CLOCK 0.101609552389411 0.646619196813319 -0.234178580237464 0.136721173066281 MirTarget -0.118908374150107 0.0249788762355227 NA NA NA hsa-let-7a-3p CNR1 0.101609552389411 0.646619196813319 -0.0181037516185518 0.968234876408631 mirMAP -0.906094370652042 1.877789620643e-07 NA NA NA hsa-let-7a-3p CNTN1 0.101609552389411 0.646619196813319 -0.820962193635968 0.0941964995418074 MirTarget;miRNATAP -1.18704389515971 1.48178227033071e-10 NA NA NA hsa-let-7a-3p COL11A1 0.101609552389411 0.646619196813319 -1.03702739332837 0.0240656064975866 MirTarget;miRNATAP -0.970828416782606 3.60625978003182e-08 NA NA NA hsa-let-7a-3p COL12A1 0.101609552389411 0.646619196813319 -0.571692978552939 0.0671027107407744 miRNATAP -0.529060979448702 3.31516730177467e-07 NA NA NA hsa-let-7a-3p COL15A1 0.101609552389411 0.646619196813319 -0.634445498398479 0.0177034704064942 MirTarget -0.43632167949533 2.21690161675284e-06 NA NA NA hsa-let-7a-3p COL1A2 0.101609552389411 0.646619196813319 -0.682626426990474 0.0675012462861772 MirTarget -0.575582831050776 5.0312162680722e-07 NA NA NA hsa-let-7a-3p COL4A1 0.101609552389411 0.646619196813319 -0.463913316816226 0.0699124638353492 miRNATAP -0.365653907996656 1.58962960214704e-07 NA NA NA hsa-let-7a-3p COL9A1 0.101609552389411 0.646619196813319 0.182232304881368 0.732654788387429 mirMAP -0.487205306846043 0.0224978366733971 NA NA NA hsa-let-7a-3p CORO1C 0.101609552389411 0.646619196813319 0.0130435477189419 0.944767569972405 MirTarget;miRNATAP -0.116389693188432 0.000187030529558234 NA NA NA hsa-let-7a-3p CPEB4 0.101609552389411 0.646619196813319 -0.143789612551509 0.384356487734189 mirMAP;miRNATAP -0.201019541093449 4.65984991816081e-05 NA NA NA hsa-let-7a-3p CRISPLD1 0.101609552389411 0.646619196813319 -0.880863399074244 0.00802403055361866 MirTarget;miRNATAP -0.822643530971888 1.71176096439252e-10 NA NA NA hsa-let-7a-3p CTSC 0.101609552389411 0.646619196813319 0.104541532838937 0.620134227692048 mirMAP -0.126134023071555 0.00791940714520071 NA NA NA hsa-let-7a-3p CUL4B 0.101609552389411 0.646619196813319 0.293878235852457 0.0652184318841543 mirMAP -0.102533503984394 0.00249375242907953 NA NA NA hsa-let-7a-3p CX3CR1 0.101609552389411 0.646619196813319 -0.105973449224505 0.711899555528994 MirTarget -0.649905828022335 3.34933773211936e-09 NA NA NA hsa-let-7a-3p CXXC4 0.101609552389411 0.646619196813319 0.283161962856212 0.402771176486893 mirMAP -0.32036646653003 0.015765170146202 NA NA NA hsa-let-7a-3p CYBRD1 0.101609552389411 0.646619196813319 -0.536198936891908 0.0587653521522923 mirMAP -0.532435077049832 2.32555312531524e-07 NA NA NA hsa-let-7a-3p CYP1B1 0.101609552389411 0.646619196813319 -0.874443498386184 0.0295556509920049 mirMAP -0.944734186539498 1.71687162408751e-09 NA NA NA hsa-let-7a-3p DAAM1 0.101609552389411 0.646619196813319 -0.283094867293415 0.0458352114374411 MirTarget -0.142707913982381 0.00395938869466693 NA NA NA hsa-let-7a-3p DAB1 0.101609552389411 0.646619196813319 0.702420838323023 0.0796321785328317 mirMAP -0.401261259763842 0.010978682769177 NA NA NA hsa-let-7a-3p DACT1 0.101609552389411 0.646619196813319 -0.876761032259375 0.00156184752217564 MirTarget -0.453218462075073 1.83766330535189e-05 NA NA NA hsa-let-7a-3p DCBLD2 0.101609552389411 0.646619196813319 0.0032663993447839 0.989040299992665 miRNATAP -0.223208352674947 0.00960798150697693 NA NA NA hsa-miR-101-3p DDIT4 0.0629937163023246 0.844386980576976 -0.2186004247388 0.408020659788112 miRNAWalker2_validate;MirTarget;miRNATAP -0.330016470287065 0.000858605408490548 NA NA NA hsa-miR-181d-5p DDIT4 0.766382344176968 0.00141892473589568 -0.2186004247388 0.408020659788112 MirTarget -0.150726957784208 0.0056584055591032 NA NA NA hsa-miR-217 DDIT4 0.208705485534886 0.459292612155867 -0.2186004247388 0.408020659788112 miRanda -0.197615123248097 5.96261128958287e-05 NA NA NA hsa-miR-30d-5p DDIT4 0.0178116929398371 0.955537710927223 -0.2186004247388 0.408020659788112 MirTarget;miRNATAP -0.217113164236439 0.0100452397210576 NA NA NA hsa-miR-30e-5p DDIT4 0.158090590539706 0.584574122071174 -0.2186004247388 0.408020659788112 MirTarget -0.2246742849091 0.0305493679595544 NA NA NA hsa-let-7a-3p DENND1B 0.101609552389411 0.646619196813319 -0.0854185691280567 0.570040463140102 mirMAP -0.117362676797518 0.0457205453175245 NA NA NA hsa-let-7a-3p DIO2 0.101609552389411 0.646619196813319 -0.237418714508066 0.413748151656944 mirMAP -0.767366402841735 1.1954298663311e-12 NA NA NA hsa-let-7a-3p DKK3 0.101609552389411 0.646619196813319 -0.462303894351177 0.0483774033693995 MirTarget;miRNATAP -0.485719504384888 3.27144956762209e-10 NA NA NA hsa-let-7a-3p DNAJB5 0.101609552389411 0.646619196813319 -0.438379220553143 0.0462963340289175 miRNATAP -0.530267204733672 2.04560349993529e-10 NA NA NA hsa-let-7a-3p DNALI1 0.101609552389411 0.646619196813319 -0.590938570861718 0.110830666905857 MirTarget;miRNATAP -0.350069086156492 0.0182219012037642 NA NA NA hsa-let-7a-3p DNM3 0.101609552389411 0.646619196813319 0.410942720868102 0.141199323161637 MirTarget -0.456955952758579 3.32005123118831e-05 NA NA NA hsa-let-7a-3p DOK6 0.101609552389411 0.646619196813319 -0.345865173188974 0.178524425195227 mirMAP -0.540171536106734 5.88079721726253e-08 NA NA NA hsa-let-7a-3p DPY19L3 0.101609552389411 0.646619196813319 0.11917953718172 0.398615791292544 mirMAP -0.115100508078479 0.0143264214122913 NA NA NA hsa-let-7a-3p DZIP1 0.101609552389411 0.646619196813319 -0.4134569757207 0.0896875195393863 MirTarget;mirMAP -0.593594243366321 1.92589260327048e-10 NA NA NA hsa-let-7a-3p EBF1 0.101609552389411 0.646619196813319 -0.374486106116829 0.0924893597735265 mirMAP;miRNATAP -0.3820874200416 1.30124282598385e-05 NA NA NA hsa-let-7a-3p EBF3 0.101609552389411 0.646619196813319 -0.639414296234988 0.0241083850491241 MirTarget;miRNATAP -0.559054382060662 4.34553391173394e-07 NA NA NA hsa-let-7a-3p EDIL3 0.101609552389411 0.646619196813319 -0.396949264659136 0.186951471751117 MirTarget -0.784545268016555 1.49841720471435e-11 NA NA NA hsa-let-7a-3p EEA1 0.101609552389411 0.646619196813319 0.361128337608248 0.025973218960136 MirTarget;miRNATAP -0.12586720007566 0.00519045184768883 NA NA NA hsa-let-7a-3p EFNA5 0.101609552389411 0.646619196813319 -1.1848780117664 0.0024062724856907 miRNATAP -0.40543498468815 0.00989547054421855 NA NA NA hsa-let-7a-3p EGFL6 0.101609552389411 0.646619196813319 -0.139699870987414 0.616643538920571 MirTarget -0.336133356278777 0.0024112159471566 NA NA NA hsa-miR-195-5p EIF4B 0.151752953269865 0.486771415518022 -0.200951099141713 0.369008310842527 MirTarget;miRNATAP -0.102716243803497 0.0011333910434656 NA NA NA hsa-miR-497-5p EIF4B 0.0588593222857097 0.74974374041188 -0.200951099141713 0.369008310842527 miRNATAP -0.143049020289145 0.000121468644640018 NA NA NA hsa-miR-130a-3p EIF4E 0.026181550942697 0.906953517484668 0.211415677279353 0.211400700978689 mirMAP -0.124499666759526 0.00106249041500023 NA NA NA hsa-miR-139-5p EIF4E -0.302162382904497 0.145994625379799 0.211415677279353 0.211400700978689 miRanda -0.112199428425707 0.00313716472717178 NA NA NA hsa-miR-145-5p EIF4E -0.216093290978916 0.520765108486316 0.211415677279353 0.211400700978689 miRNAWalker2_validate;miRTarBase -0.127405505660348 7.71222721286519e-05 NA NA NA hsa-miR-29c-3p EIF4E 0.0197591608436092 0.946014399511523 0.211415677279353 0.211400700978689 mirMAP -0.105127991824042 0.00551185953467407 NA NA NA hsa-miR-30a-3p EIF4E -0.0105521458830058 0.970340882699089 0.211415677279353 0.211400700978689 mirMAP -0.13405069081027 0.00696291799899749 NA NA NA hsa-miR-485-3p EIF4E -0.305870403763477 0.163882968286279 0.211415677279353 0.211400700978689 MirTarget;mirMAP -0.108031007406798 0.000749086773309524 NA NA NA hsa-miR-125b-5p EIF4EBP1 -0.264179368065651 0.382703105610114 -0.106292995419444 0.627118019221959 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.140179204025962 0.00143796990077998 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-miR-874-3p EIF4EBP1 0.133646482406215 0.599823580645941 -0.106292995419444 0.627118019221959 MirTarget -0.10084577317316 0.0257122278604746 NA NA NA hsa-let-7a-3p ELAVL2 0.101609552389411 0.646619196813319 0.582329823444815 0.259334791473112 MirTarget;mirMAP;miRNATAP -0.421324563581095 0.041360048720939 NA NA NA hsa-let-7a-3p ELK3 0.101609552389411 0.646619196813319 -0.241520681957879 0.148412476351148 MirTarget -0.383269325024311 1.07211664536951e-10 NA NA NA hsa-let-7a-3p ELL2 0.101609552389411 0.646619196813319 -0.128187832860053 0.474635285033477 mirMAP -0.133460953353326 0.0107471630920249 NA NA NA hsa-let-7a-3p ELOVL2 0.101609552389411 0.646619196813319 -0.732320722277939 0.0190371278157978 miRNATAP -0.487850080991159 4.6881192534931e-05 NA NA NA hsa-let-7a-3p EML1 0.101609552389411 0.646619196813319 -0.236474052529879 0.353355831622058 MirTarget -0.561713294471944 1.32243125137611e-08 NA NA NA hsa-let-7a-3p ENTPD1 0.101609552389411 0.646619196813319 -0.275537478075178 0.11934907469987 mirMAP -0.272873749057761 1.35044519625476e-08 NA NA NA hsa-let-7a-3p EPHA3 0.101609552389411 0.646619196813319 -0.117213480827407 0.694717073897294 mirMAP;miRNATAP -0.781966830350823 7.57068361826318e-12 NA NA NA hsa-let-7a-3p EPHA7 0.101609552389411 0.646619196813319 -0.473053301839951 0.287532665509935 mirMAP;miRNATAP -0.583498078595759 0.000948844438079671 NA NA NA hsa-let-7a-3p ESR1 0.101609552389411 0.646619196813319 -0.7949268431828 0.0110670387631077 mirMAP -0.597157105347607 8.17321648824779e-07 20535543;21826373 Let 7 family miRNAs regulate estrogen receptor alpha signaling in estrogen receptor positive breast cancer; Next we performed bioinformatics analysis and found that let-7 miRNA sequences match sequence in the 3'-UTR of estrogen receptor alpha ER-α suggesting ER-α may be a target of let-7 which was further confirmed by a number of experimental assays including luciferase assay protein expression and mRNA expression;let 7 microRNAs induce tamoxifen sensitivity by downregulation of estrogen receptor α signaling in breast cancer ; breast cancer;breast cancer hsa-let-7a-3p EVI2A 0.101609552389411 0.646619196813319 -0.529644417524417 0.0451952274765523 MirTarget -0.628283415514803 8.50786126437153e-10 NA NA NA hsa-let-7a-3p EYA4 0.101609552389411 0.646619196813319 -0.715485412664449 0.060322848403705 miRNATAP -0.533736884249879 0.000366577785470679 NA NA NA hsa-let-7a-3p FAM126A 0.101609552389411 0.646619196813319 -0.143754759633807 0.521063971533598 MirTarget -0.422440620275407 1.00135778477825e-06 NA NA NA hsa-let-7a-3p FAM19A1 0.101609552389411 0.646619196813319 -0.746662137873913 0.0400332924494345 miRNATAP -0.666520886646331 2.84060277095394e-06 NA NA NA hsa-let-7a-3p FAM19A2 0.101609552389411 0.646619196813319 -0.210584403692219 0.425127065922363 miRNATAP -0.313227353574939 0.001985989612733 NA NA NA hsa-let-7a-3p FAM19A5 0.101609552389411 0.646619196813319 -0.466335178222526 0.0752526407490701 MirTarget;miRNATAP -0.561865619906762 2.60426764325746e-08 NA NA NA hsa-let-7a-3p FAM26E 0.101609552389411 0.646619196813319 -0.408931688857617 0.1210848220688 mirMAP -0.636326700290193 3.77046985871128e-10 NA NA NA hsa-let-7a-3p FAM63B 0.101609552389411 0.646619196813319 -0.407879394402181 0.0141345508155549 mirMAP -0.314260318760196 1.07206454797211e-06 NA NA NA hsa-let-7a-3p FAT3 0.101609552389411 0.646619196813319 -0.116313673867674 0.719455462704857 miRNATAP -0.659973336881943 1.02820078969436e-07 NA NA NA hsa-let-7a-3p FBN1 0.101609552389411 0.646619196813319 -0.640231825951681 0.0466001778262169 mirMAP -0.761447344194889 3.2096333395523e-11 NA NA NA hsa-let-7a-3p FBXO32 0.101609552389411 0.646619196813319 -0.42392674542806 0.0398945295810563 mirMAP -0.247347905616606 0.000598561589620743 NA NA NA hsa-let-7a-3p FGF12 0.101609552389411 0.646619196813319 -0.490870662609923 0.0433246939595278 MirTarget -0.31967445902099 0.000591732965496754 NA NA NA hsa-let-7a-3p FGF13 0.101609552389411 0.646619196813319 -0.0208577890974078 0.947661143286377 MirTarget;miRNATAP -0.413074100574929 0.00107885043966615 NA NA NA hsa-let-7a-3p FGF2 0.101609552389411 0.646619196813319 -0.330576739748857 0.25942353762238 mirMAP -0.508812543963832 9.06476874891136e-06 NA NA NA hsa-let-7a-3p FGF7 0.101609552389411 0.646619196813319 -0.41888320225971 0.175083247702136 MirTarget;miRNATAP -0.683797140192053 9.84850919759302e-09 NA NA NA hsa-let-7a-3p FIGN 0.101609552389411 0.646619196813319 -0.453425063791731 0.170002389000214 mirMAP -0.73644789469253 3.78173302136355e-09 NA NA NA hsa-let-7a-3p FKBP7 0.101609552389411 0.646619196813319 -0.237093805098451 0.115109867931807 mirMAP -0.211179673926529 4.78439504428086e-05 NA NA NA hsa-let-7a-3p FLRT2 0.101609552389411 0.646619196813319 -0.454613499185029 0.158020832208713 mirMAP -0.741676555845987 2.5148093772764e-09 NA NA NA hsa-let-7a-3p FNDC3B 0.101609552389411 0.646619196813319 -0.00434515231692156 0.981307045678396 MirTarget -0.124438134559055 0.00405372828812947 NA NA NA hsa-let-7a-3p FOXP2 0.101609552389411 0.646619196813319 -0.511866566024407 0.310901143397511 MirTarget;mirMAP -0.870923086669036 1.12380632065085e-05 NA NA NA hsa-let-7a-3p FREM2 0.101609552389411 0.646619196813319 2.31172822414012 0.000335162211506439 MirTarget;mirMAP -0.524865452368208 0.0458017271110444 NA NA NA hsa-let-7a-3p FRMD4A 0.101609552389411 0.646619196813319 -0.159138106014087 0.340438347485013 miRNATAP -0.170556861033641 0.00506573278096563 NA NA NA hsa-let-7a-3p FRMD6 0.101609552389411 0.646619196813319 -0.47158779787698 0.0735385958701097 MirTarget;mirMAP -0.63646027716623 8.36743043619176e-11 NA NA NA hsa-let-7a-3p FSTL1 0.101609552389411 0.646619196813319 -0.40778812047402 0.123264151157375 mirMAP -0.523542668772006 3.82904285549215e-11 NA NA NA hsa-let-7a-3p FYB 0.101609552389411 0.646619196813319 -0.389834293452517 0.163653404974817 MirTarget -0.485136734451741 9.05551305437503e-06 NA NA NA hsa-let-7a-3p FZD4 0.101609552389411 0.646619196813319 -0.547311138140124 0.00118196878002201 mirMAP -0.24235415493525 1.98163871311651e-05 NA NA NA hsa-let-7a-3p FZD6 0.101609552389411 0.646619196813319 0.126162657662249 0.467416718061878 MirTarget;mirMAP -0.115231878920242 0.0233074142014958 NA NA NA hsa-let-7a-3p GABRA2 0.101609552389411 0.646619196813319 0.0931973368704283 0.85804426326656 mirMAP -0.768036889517321 0.00019493247375222 NA NA NA hsa-let-7a-3p GABRB3 0.101609552389411 0.646619196813319 0.114376118540279 0.841011525656904 miRNATAP -0.922094274557611 3.47429664749129e-05 NA NA NA hsa-let-7a-3p GAS1 0.101609552389411 0.646619196813319 -0.963569402955913 0.0221135399061751 miRNATAP -0.868132357338781 1.46415340470527e-07 NA NA NA hsa-let-7a-3p GATA3 0.101609552389411 0.646619196813319 -0.470643349808624 0.0568485600626434 MirTarget;miRNATAP -0.351252012305017 0.000348715281871325 NA NA NA hsa-let-7a-3p GDF11 0.101609552389411 0.646619196813319 -0.0818754319048676 0.629731607223527 mirMAP -0.181806016899018 0.00389520324447588 NA NA NA hsa-let-7a-3p GFRA1 0.101609552389411 0.646619196813319 -0.543913142982878 0.205468170068542 mirMAP;miRNATAP -0.896353737518595 9.80548282608087e-08 NA NA NA hsa-let-7a-3p GFRA2 0.101609552389411 0.646619196813319 -0.624480961904537 0.0672710055189368 mirMAP -0.529804420559979 6.60536105671701e-05 NA NA NA hsa-let-7a-3p GJC1 0.101609552389411 0.646619196813319 -0.391113073152504 0.0524437688336822 mirMAP -0.443236433200303 1.00547975956862e-08 NA NA NA hsa-let-7a-3p GLIS3 0.101609552389411 0.646619196813319 -0.648556037165647 0.0221515710211939 mirMAP -0.383101414513831 0.000628452291859086 NA NA NA hsa-let-7a-3p GNB4 0.101609552389411 0.646619196813319 -0.486162762914658 0.0297854277658707 MirTarget -0.527462288702162 1.32800230080668e-10 NA NA NA hsa-let-7a-3p GPC6 0.101609552389411 0.646619196813319 -0.420659392364141 0.131232989397087 MirTarget -0.681584958240194 9.19876124078797e-11 NA NA NA hsa-let-7a-3p GPM6B 0.101609552389411 0.646619196813319 -0.2523282699042 0.339938273538966 mirMAP;miRNATAP -0.424041122374258 5.1231691525337e-05 NA NA NA hsa-let-7a-3p GREM1 0.101609552389411 0.646619196813319 -0.647300130692107 0.133863860038474 mirMAP -0.893834427289059 2.17444389636331e-08 NA NA NA hsa-let-7a-3p GRIN2A 0.101609552389411 0.646619196813319 -0.223003749481729 0.58353050514589 mirMAP -0.682673872890101 8.80479134013245e-06 NA NA NA hsa-let-7a-3p GTF2A1 0.101609552389411 0.646619196813319 -0.173873377314398 0.207690411448806 MirTarget;miRNATAP -0.180737031030294 0.000495425656136684 NA NA NA hsa-let-7a-3p GTF2I 0.101609552389411 0.646619196813319 -0.112647603678616 0.513515319961644 MirTarget -0.106563156563109 0.0102296332451555 NA NA NA hsa-let-7a-3p GULP1 0.101609552389411 0.646619196813319 -0.188233480817111 0.492525089448287 MirTarget;mirMAP -0.612870551730645 4.98402295410739e-09 NA NA NA hsa-let-7a-3p HCFC2 0.101609552389411 0.646619196813319 -0.244787798139198 0.0722450656537538 miRNATAP -0.234232618366014 1.2174608132371e-06 NA NA NA hsa-let-7a-3p HDAC9 0.101609552389411 0.646619196813319 -0.177125728502235 0.549894234758351 miRNATAP -0.417395572708732 0.000362735696464937 NA NA NA hsa-let-7a-3p HDX 0.101609552389411 0.646619196813319 0.194404269978676 0.530600597854478 mirMAP -0.414508531356488 0.000684683114507113 NA NA NA hsa-let-7a-3p HECTD2 0.101609552389411 0.646619196813319 0.0872163193233217 0.64175603609649 miRNATAP -0.427462015855406 2.90749733539747e-09 NA NA NA hsa-let-7a-3p HGF 0.101609552389411 0.646619196813319 -0.396621267941527 0.24479079196479 mirMAP -0.88420347185405 1.1709285303706e-11 NA NA NA hsa-let-7a-3p HHIP 0.101609552389411 0.646619196813319 -0.213263299604178 0.610631404564501 mirMAP -0.858795930138885 1.41232355504352e-07 NA NA NA hsa-let-7a-3p HIC1 0.101609552389411 0.646619196813319 -0.301443588715929 0.134301752205435 MirTarget -0.333832535637522 1.50370719651293e-05 NA NA NA hsa-miR-106a-5p HIF1A 0.542051091047854 0.00782852255091914 -0.344681780882448 0.0883316439642389 MirTarget -0.210533974131567 1.61663798213016e-06 NA NA NA hsa-miR-106b-3p HIF1A 0.0200215717848504 0.938723790423287 -0.344681780882448 0.0883316439642389 miRNAWalker2_validate -0.120444044559669 0.0378849050791357 NA NA NA hsa-miR-106b-5p HIF1A 0.284551111571426 0.277367924981826 -0.344681780882448 0.0883316439642389 MirTarget -0.235717194989505 3.67529452147292e-06 NA NA NA hsa-miR-143-5p HIF1A -0.165643803169066 0.495461680065083 -0.344681780882448 0.0883316439642389 MirTarget -0.164356213763891 8.60060915695144e-05 NA NA NA hsa-miR-151a-3p HIF1A 0.278266737257166 0.35554913228907 -0.344681780882448 0.0883316439642389 MirTarget -0.154693338699039 0.0186604928262686 NA NA NA hsa-miR-15b-3p HIF1A 0.253700501723044 0.258816254433513 -0.344681780882448 0.0883316439642389 MirTarget -0.100117145966502 0.031314948727488 NA NA NA hsa-miR-17-5p HIF1A 0.654454113630718 0.0320922529414325 -0.344681780882448 0.0883316439642389 miRTarBase;MirTarget;TargetScan -0.221662155977467 6.9890203833283e-09 NA NA NA hsa-miR-18a-5p HIF1A 0.681200811788969 0.0155752938583483 -0.344681780882448 0.0883316439642389 miRNAWalker2_validate;MirTarget -0.147214629397058 5.85316437926587e-06 25069832 Last clinically relevant correlations between miR-18a HIF1A hypoxia-responsive gene expression and distant metastasis-free survival DMFS were assessed using published expression array breast tumors data sets; We identified HIF1A as a direct target of miR-18a; Analysis of previously published data revealed that higher expression of HIF1A and a panel of hypoxic genes is associated with shorter DMFS interval in patients with basal-like breast tumors and that within this subtype miR-18a expression is inversely correlated with hypoxic gene expression; The results of this study reveal a novel role for miR-18a in targeting HIF1A and repressing metastasis of basal-like breast tumors metastasis;poor survival breast cancer hsa-miR-18b-5p HIF1A 0.603572755818254 0.0278111657503767 -0.344681780882448 0.0883316439642389 MirTarget -0.116293204667259 0.000288531789428482 NA NA NA hsa-miR-20a-5p HIF1A 0.575987288988369 0.0504195522708827 -0.344681780882448 0.0883316439642389 miRNAWalker2_validate;miRTarBase;MirTarget -0.186261234876526 1.02812634417279e-06 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-28-5p HIF1A 0.0604291342924528 0.724528361387472 -0.344681780882448 0.0883316439642389 miRanda -0.421346541019449 0.00043537283423571 NA NA NA hsa-miR-33a-5p HIF1A 0.746536711988929 0.0426876261010534 -0.344681780882448 0.0883316439642389 miRNAWalker2_validate -0.129858218171177 4.47012912343829e-08 NA NA NA hsa-miR-361-5p HIF1A 0.287346232931998 0.184174010002836 -0.344681780882448 0.0883316439642389 miRanda -0.359659345623 1.61482457321694e-06 NA NA NA hsa-miR-424-5p HIF1A 0.362472054054227 0.208698146989944 -0.344681780882448 0.0883316439642389 miRNAWalker2_validate;miRTarBase -0.128780347723095 0.000587955252529107 NA NA NA hsa-miR-660-5p HIF1A 0.155245961216719 0.489684774612498 -0.344681780882448 0.0883316439642389 MirTarget -0.211376442975206 3.53588347818025e-06 NA NA NA hsa-miR-93-5p HIF1A 0.240698477893627 0.478488479349248 -0.344681780882448 0.0883316439642389 MirTarget -0.137554810283225 0.00487612403744103 NA NA NA hsa-let-7a-3p HIP1 0.101609552389411 0.646619196813319 -0.0786045904081352 0.664814228717575 MirTarget;miRNATAP -0.195067738691898 0.00126000013783693 NA NA NA hsa-let-7a-3p HIPK3 0.101609552389411 0.646619196813319 -0.159892057220539 0.311266107689572 mirMAP -0.264297700399773 2.21278413162999e-07 NA NA NA hsa-let-7a-3p HIVEP2 0.101609552389411 0.646619196813319 -0.163422886709918 0.280873996575213 miRNATAP -0.120046187052893 0.00301849747253993 NA NA NA hsa-let-7a-3p HLF 0.101609552389411 0.646619196813319 0.154420887885897 0.544920698174217 mirMAP -0.28369345732238 0.0055693694008634 NA NA NA hsa-let-7a-3p HOOK3 0.101609552389411 0.646619196813319 -0.0133376515067987 0.936883355869389 MirTarget -0.142907141848588 0.00367248470160385 NA NA NA hsa-let-7a-3p HOXC8 0.101609552389411 0.646619196813319 -0.860498738629325 0.077681565886695 miRNATAP -0.413834900109151 0.0303125756855472 NA NA NA hsa-let-7a-3p IDS 0.101609552389411 0.646619196813319 0.136655986251423 0.448716775851807 mirMAP -0.257564382804785 1.4044033135798e-08 NA NA NA hsa-let-7a-3p IFIT1 0.101609552389411 0.646619196813319 0.546927415381001 0.07565415954739 MirTarget -0.39197945578924 0.00117327802200347 NA NA NA hsa-let-7a-3p IGF1 0.101609552389411 0.646619196813319 -0.305513697425213 0.466810993899486 mirMAP -1.080447980324 1.8079365656541e-11 NA NA NA hsa-let-7f-1-3p IGF1 0.0232337533686442 0.882480601364687 -0.305513697425213 0.466810993899486 mirMAP -1.33703011462655 1.62041677524579e-09 NA NA NA hsa-miR-101-5p IGF1 0.158890606517147 0.486554301807487 -0.305513697425213 0.466810993899486 mirMAP -0.320742286016842 0.0123585270262967 NA NA NA hsa-miR-1275 IGF1 0.826421555845947 0.00690634946385774 -0.305513697425213 0.466810993899486 MirTarget;PITA -0.38101781548121 5.45983739511041e-05 NA NA NA hsa-miR-130b-3p IGF1 0.426186909383556 0.0535253475456448 -0.305513697425213 0.466810993899486 MirTarget -1.32997411476354 1.36901225432237e-20 NA NA NA hsa-miR-148a-5p IGF1 -0.0350223755826597 0.885849057601304 -0.305513697425213 0.466810993899486 mirMAP -0.731184313112099 6.87872094016325e-07 NA NA NA hsa-miR-15b-3p IGF1 0.253700501723044 0.258816254433513 -0.305513697425213 0.466810993899486 mirMAP -1.37193595831155 3.68702917896959e-22 NA NA NA hsa-miR-16-1-3p IGF1 0.487307456530415 0.0245993275593527 -0.305513697425213 0.466810993899486 mirMAP -0.870110401826923 9.48782291894495e-12 NA NA NA hsa-miR-186-5p IGF1 0.0414271542658895 0.855875332337529 -0.305513697425213 0.466810993899486 mirMAP -1.35027272960641 3.80273001614756e-11 NA NA NA hsa-miR-19a-3p IGF1 0.492121782019476 0.0512469162191149 -0.305513697425213 0.466810993899486 MirTarget -0.98551271469101 4.98535421174768e-17 NA NA NA hsa-miR-19b-1-5p IGF1 0.591010763154988 0.00565243902441125 -0.305513697425213 0.466810993899486 mirMAP -0.955450359137311 6.7696545868365e-13 NA NA NA hsa-miR-19b-3p IGF1 0.54121896996679 0.0308428363133693 -0.305513697425213 0.466810993899486 MirTarget -1.18511578469291 3.16855554305294e-17 NA NA NA hsa-miR-20a-3p IGF1 0.876699550562228 0.00158288982550849 -0.305513697425213 0.466810993899486 mirMAP -0.828202370369737 4.46601232058444e-17 NA NA NA hsa-miR-224-3p IGF1 0.353739142547605 0.145676386055594 -0.305513697425213 0.466810993899486 mirMAP -0.323141310332858 0.00752558553987227 NA NA NA hsa-miR-26b-5p IGF1 0.124364243009017 0.63657079673149 -0.305513697425213 0.466810993899486 mirMAP -1.32653848815452 7.59461749262891e-12 NA NA NA hsa-miR-27a-3p IGF1 0.0134054647308091 0.962166646551862 -0.305513697425213 0.466810993899486 miRNAWalker2_validate;miRTarBase -1.33297141089179 1.59629899773494e-08 NA NA NA hsa-miR-29a-3p IGF1 0.422455884388283 0.210846507695107 -0.305513697425213 0.466810993899486 MirTarget -1.21646810613425 2.24809293601906e-10 NA NA NA hsa-miR-29b-3p IGF1 0.576937416051043 0.0425757132324386 -0.305513697425213 0.466810993899486 MirTarget -1.13478255405874 1.02581838525823e-15 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 0.350506157574251 0.119327493804133 -0.305513697425213 0.466810993899486 MirTarget -0.72462477830808 1.53712615625093e-08 NA NA NA hsa-miR-32-3p IGF1 0.331827826560311 0.224850265700549 -0.305513697425213 0.466810993899486 mirMAP -0.854296588628844 6.36098490896109e-17 NA NA NA hsa-miR-320a IGF1 0.0445132408352098 0.868835492785552 -0.305513697425213 0.466810993899486 miRNATAP -0.53324783195833 0.00309104675893166 NA NA NA hsa-miR-320b IGF1 0.0476110968391366 0.835429263750272 -0.305513697425213 0.466810993899486 miRNATAP -0.392947422881607 0.0155214206184154 NA NA NA hsa-miR-33a-3p IGF1 0.0801132536031662 0.726683004542423 -0.305513697425213 0.466810993899486 MirTarget -0.712659254532177 1.07475387901444e-08 NA NA NA hsa-miR-361-5p IGF1 0.287346232931998 0.184174010002836 -0.305513697425213 0.466810993899486 PITA;mirMAP -0.7571457599163 0.00312625171582628 NA NA NA hsa-miR-362-5p IGF1 0.506367125681149 0.0511376993060576 -0.305513697425213 0.466810993899486 mirMAP -0.685362314110393 1.45434246224861e-09 NA NA NA hsa-miR-369-3p IGF1 0.135995136901538 0.499460414151147 -0.305513697425213 0.466810993899486 mirMAP -0.416113550798216 0.00731803332568262 NA NA NA hsa-miR-374b-3p IGF1 0.321610729155931 0.0677465289018739 -0.305513697425213 0.466810993899486 mirMAP -0.901177033447461 2.85340453160353e-08 NA NA NA hsa-miR-376b-3p IGF1 0.0962331370146978 0.684715238977878 -0.305513697425213 0.466810993899486 mirMAP -0.400180241759986 0.00219046891964139 NA NA NA hsa-miR-377-3p IGF1 0.19330495703325 0.39915950351112 -0.305513697425213 0.466810993899486 mirMAP -0.347398016761275 0.00944572443583628 NA NA NA hsa-miR-421 IGF1 0.483846282376657 0.0175641163246583 -0.305513697425213 0.466810993899486 PITA -0.682640976463619 1.66568557959283e-06 NA NA NA hsa-miR-450b-5p IGF1 0.00436780818154059 0.982506709891873 -0.305513697425213 0.466810993899486 MirTarget;PITA;mirMAP;miRNATAP -0.440274691286941 0.00526886632157137 NA NA NA hsa-miR-452-5p IGF1 0.411009568588075 0.11464943261481 -0.305513697425213 0.466810993899486 MirTarget;mirMAP -0.391677573462921 0.00721587803462884 NA NA NA hsa-miR-454-3p IGF1 0.493936490517753 0.00397224628288767 -0.305513697425213 0.466810993899486 MirTarget -1.21083489236632 2.3904507521785e-12 NA NA NA hsa-miR-486-5p IGF1 -0.423622845821328 0.173008139942845 -0.305513697425213 0.466810993899486 PITA;miRNATAP -0.27962476093108 0.00602263294023068 NA NA NA hsa-miR-576-5p IGF1 -0.0646836612801551 0.749193541371544 -0.305513697425213 0.466810993899486 PITA;mirMAP;miRNATAP -1.07532866336442 7.30778925637395e-14 NA NA NA hsa-miR-577 IGF1 -0.131565620416609 0.724256245908512 -0.305513697425213 0.466810993899486 PITA -0.608739982603203 1.28953846721018e-16 NA NA NA hsa-miR-590-3p IGF1 0.61452706068502 0.00851921195946504 -0.305513697425213 0.466810993899486 MirTarget;miRanda;mirMAP;miRNATAP -0.902455239090903 4.54122052117076e-14 NA NA NA hsa-miR-592 IGF1 1.86717823603616 2.16983885695828e-05 -0.305513697425213 0.466810993899486 mirMAP -0.176568829642714 0.00558894888386371 NA NA NA hsa-miR-629-5p IGF1 0.460654946207789 0.0737631204363581 -0.305513697425213 0.466810993899486 mirMAP -0.580583415149519 2.61578695347913e-05 NA NA NA hsa-miR-940 IGF1 0.679629459432135 0.0112736412614729 -0.305513697425213 0.466810993899486 MirTarget;PITA;miRNATAP -0.565084064749585 9.24954782359072e-08 NA NA NA hsa-let-7a-3p IGFBP3 0.101609552389411 0.646619196813319 -0.327367301717631 0.211843744495959 miRNATAP -0.427943062808335 1.71361067788621e-07 NA NA NA hsa-let-7a-3p IL6ST 0.101609552389411 0.646619196813319 -0.318032259655175 0.142855934958276 mirMAP -0.462380603035303 1.58090637221431e-08 NA NA NA hsa-let-7a-3p IPMK 0.101609552389411 0.646619196813319 0.222907256074214 0.155664264034885 mirMAP -0.141777827524199 0.0212061280796338 NA NA NA hsa-let-7a-3p ITGAV 0.101609552389411 0.646619196813319 -0.258782816952357 0.185834558813929 MirTarget -0.277150422479031 4.02095600400644e-08 NA NA NA hsa-let-7a-3p JAG1 0.101609552389411 0.646619196813319 -0.0532830868462275 0.790825242750594 MirTarget;miRNATAP -0.123995296282957 0.0347215471551958 NA NA NA hsa-let-7a-3p KCNJ15 0.101609552389411 0.646619196813319 -0.762274635713846 0.0326774787569916 MirTarget -0.756608284385165 5.18752796366538e-08 NA NA NA hsa-let-7a-3p KCTD12 0.101609552389411 0.646619196813319 -0.96694500634699 0.00100758506944431 MirTarget -0.44705454065704 2.44414686577257e-05 NA NA NA hsa-let-7a-3p KCTD15 0.101609552389411 0.646619196813319 -0.737612937163547 0.00136915901352694 miRNATAP -0.277863622377142 0.0013208347140948 NA NA NA hsa-let-7a-3p KIAA0408 0.101609552389411 0.646619196813319 -0.588482440732982 0.25702071647445 MirTarget -0.648887511918315 0.00118313058758307 NA NA NA hsa-let-7a-3p KIAA2022 0.101609552389411 0.646619196813319 -0.471298913236709 0.243318135736701 MirTarget;mirMAP -1.0134723822977 1.16098383913344e-11 NA NA NA hsa-let-7a-3p KIF5C 0.101609552389411 0.646619196813319 -0.541165621908689 0.0274763097910457 miRNATAP -0.244696177529361 0.0127359727333551 NA NA NA hsa-let-7a-3p KIT 0.101609552389411 0.646619196813319 -0.565938334943255 0.0721395880370137 mirMAP -0.3809217229143 0.00182630278028915 NA NA NA hsa-let-7a-3p KLF12 0.101609552389411 0.646619196813319 -0.196347096956982 0.435271598204268 MirTarget -0.243767405183734 0.0137811475173317 NA NA NA hsa-let-7a-3p KLF7 0.101609552389411 0.646619196813319 -0.00227391938146759 0.991924646461907 miRNATAP -0.260480268831857 0.00399934229946505 NA NA NA hsa-let-7a-3p KLF8 0.101609552389411 0.646619196813319 -0.310411485729106 0.173526503760284 mirMAP -0.482446483385725 6.98231469266266e-08 NA NA NA hsa-let-7a-3p KLHL20 0.101609552389411 0.646619196813319 -0.031414394919473 0.787694727299978 MirTarget -0.119351441620932 0.000228566189795446 NA NA NA hsa-let-7a-3p KLHL4 0.101609552389411 0.646619196813319 -0.579078618849239 0.0818283426135454 mirMAP -0.799272292300742 3.08517454874839e-10 NA NA NA hsa-let-7a-3p KPNA5 0.101609552389411 0.646619196813319 0.190965256598594 0.260994503738174 mirMAP -0.154341847554917 0.0240009751459629 NA NA NA hsa-let-7a-3p LAMP2 0.101609552389411 0.646619196813319 0.4032888837331 0.0370767267806702 mirMAP;miRNATAP -0.116853592876946 0.00637030084647504 NA NA NA hsa-let-7a-3p LATS1 0.101609552389411 0.646619196813319 -0.151051313151983 0.253690362151588 MirTarget;mirMAP -0.117427799621448 0.0108454612093953 NA NA NA hsa-let-7a-3p LCOR 0.101609552389411 0.646619196813319 0.0596003188407503 0.727090246044248 mirMAP;miRNATAP -0.182032382696032 0.00515621686626681 NA NA NA hsa-let-7a-3p LEF1 0.101609552389411 0.646619196813319 -0.442086957318583 0.0633774210215325 miRNATAP -0.376892958550269 4.01542672003822e-05 NA NA NA hsa-let-7a-3p LEPR 0.101609552389411 0.646619196813319 -0.266741162479507 0.190176205109952 mirMAP -0.222152295467266 0.00453719470781161 NA NA NA hsa-let-7a-3p LIFR 0.101609552389411 0.646619196813319 -0.488610892370218 0.108924027114687 mirMAP -0.672277431183378 1.66141312929081e-08 NA NA NA hsa-let-7a-3p LIMS1 0.101609552389411 0.646619196813319 -0.164029707694973 0.241270639412611 mirMAP -0.281477201884279 1.8895448002623e-10 NA NA NA hsa-let-7a-3p LIMS3 0.101609552389411 0.646619196813319 -0.573864515943775 0.0651818351048709 MirTarget -0.362058744286417 0.00250804034193844 NA NA NA hsa-let-7a-3p LIN7A 0.101609552389411 0.646619196813319 0.451609716140359 0.293629138018724 mirMAP -0.470725411984581 0.0060751985466822 NA NA NA hsa-let-7a-3p LMO3 0.101609552389411 0.646619196813319 -0.667875105335942 0.183002991956854 MirTarget -1.31720632812077 6.58525679826344e-12 NA NA NA hsa-let-7a-3p LRCH3 0.101609552389411 0.646619196813319 -0.117887537542894 0.276539168467229 mirMAP -0.140740536744936 6.69674504856347e-05 NA NA NA hsa-let-7a-3p LRRC32 0.101609552389411 0.646619196813319 -0.261606624802423 0.242927646769264 MirTarget;miRNATAP -0.427118098222409 2.37050602903931e-08 NA NA NA hsa-let-7a-3p LRRC4 0.101609552389411 0.646619196813319 -0.0624013195088226 0.82578006165323 miRNATAP -0.400037615695035 0.000354211844721839 NA NA NA hsa-let-7a-3p LRRC8C 0.101609552389411 0.646619196813319 -0.493041029006842 0.00443430958520347 mirMAP -0.28962358850819 9.30069894549611e-06 NA NA NA hsa-let-7a-3p LRRK2 0.101609552389411 0.646619196813319 -0.433809623346755 0.212950415780758 mirMAP -0.854943086038784 2.27507965632339e-10 NA NA NA hsa-let-7a-3p LSP1 0.101609552389411 0.646619196813319 -0.679453397330219 0.00508062250758552 MirTarget -0.360972523147935 4.80786809193223e-05 NA NA NA hsa-let-7a-3p MAFB 0.101609552389411 0.646619196813319 -0.769738980963414 0.00421860189805291 miRNATAP -0.582328354287651 1.26443244826702e-08 NA NA NA hsa-let-7a-3p MALT1 0.101609552389411 0.646619196813319 -0.100416810086815 0.517802903249872 MirTarget -0.100967794066316 0.0259426032137535 NA NA NA hsa-let-7a-3p MAN1A1 0.101609552389411 0.646619196813319 -0.475617613638559 0.0250346294470204 MirTarget -0.165394175457017 0.0270660277910747 NA NA NA hsa-let-7a-3p MAP1B 0.101609552389411 0.646619196813319 -0.531951371388073 0.0276436424804887 mirMAP -0.551920209635696 1.84168643146647e-09 NA NA NA hsa-let-7a-3p MAP2 0.101609552389411 0.646619196813319 -0.490960464348299 0.0802129585493038 MirTarget;miRNATAP -0.618358819954705 1.44808333013156e-08 NA NA NA hsa-let-7a-3p MAP9 0.101609552389411 0.646619196813319 -0.279601068241779 0.372855272228674 mirMAP -0.720358811340553 2.6339264668964e-09 NA NA NA hsa-let-7a-3p MARCH1 0.101609552389411 0.646619196813319 -0.380017621180691 0.0633960801750136 miRNATAP -0.367746412330056 5.30556900735131e-06 NA NA NA hsa-let-7a-3p MAST4 0.101609552389411 0.646619196813319 -0.123674123019577 0.499243419256216 miRNATAP -0.231053452897492 0.00143172473764831 NA NA NA hsa-let-7a-3p MBNL3 0.101609552389411 0.646619196813319 -0.223851079647948 0.241470411998574 mirMAP;miRNATAP -0.206480344455515 0.00709988290303339 NA NA NA hsa-let-7a-3p MDFIC 0.101609552389411 0.646619196813319 -0.590854071564773 0.0140866629140655 MirTarget -0.326537816031061 0.000390628085805528 NA NA NA hsa-let-7a-3p MEF2A 0.101609552389411 0.646619196813319 -0.195791267567762 0.155370563865291 mirMAP -0.103322051099513 0.00171123607812761 NA NA NA hsa-let-7a-3p MEF2C 0.101609552389411 0.646619196813319 -0.349221246125389 0.10502131732148 MirTarget;miRNATAP -0.444495121511938 2.38223100299587e-08 NA NA NA hsa-let-7a-3p MEX3B 0.101609552389411 0.646619196813319 -0.382586100960063 0.0519363010545436 miRNATAP -0.426479850375075 2.15872435242819e-08 NA NA NA hsa-let-7a-3p MFAP3L 0.101609552389411 0.646619196813319 0.609766775212742 0.032295412542237 mirMAP -0.237450951910968 0.0332582685373011 NA NA NA hsa-let-7a-3p MGAT5 0.101609552389411 0.646619196813319 0.225686616395513 0.271236010209356 mirMAP -0.172469479098789 0.0203017005254976 NA NA NA hsa-let-7a-3p MITF 0.101609552389411 0.646619196813319 -0.672375010688566 0.0119303857098657 MirTarget;miRNATAP -0.627542324270645 1.05620850068141e-09 NA NA NA hsa-let-7a-3p MSRB3 0.101609552389411 0.646619196813319 -0.607277696567456 0.0377001112777501 miRNATAP -0.846954699893699 4.06459966851557e-15 NA NA NA hsa-let-7a-3p MTMR9 0.101609552389411 0.646619196813319 -0.113672312650744 0.394830683118186 mirMAP -0.136638639697206 0.00196435926484329 NA NA NA hsa-let-7a-3p MYCBP2 0.101609552389411 0.646619196813319 0.0631909628974858 0.715539932506466 MirTarget;miRNATAP -0.10905335040602 0.024833920584512 NA NA NA hsa-let-7a-3p MYLK 0.101609552389411 0.646619196813319 -0.430568788907556 0.154452735593713 mirMAP -0.830839649170453 7.14260540967775e-15 NA NA NA hsa-let-7a-3p MYO9A 0.101609552389411 0.646619196813319 -0.102645138075478 0.489459233427615 mirMAP -0.224737685178797 4.60047039667553e-05 NA NA NA hsa-let-7a-3p N4BP2 0.101609552389411 0.646619196813319 -0.373555962690204 0.0233295850289228 mirMAP -0.258825289334365 4.38665170506086e-05 NA NA NA hsa-let-7a-3p NALCN 0.101609552389411 0.646619196813319 -0.63977069301101 0.154768232331673 MirTarget -1.02575666908749 2.9906002423697e-09 NA NA NA hsa-let-7a-3p NAV1 0.101609552389411 0.646619196813319 -0.0158798174755166 0.94147266647775 miRNATAP -0.268610957463315 0.000603529536705886 NA NA NA hsa-let-7a-3p NBEA 0.101609552389411 0.646619196813319 -1.00128413284071 0.00672006078318685 MirTarget;miRNATAP -0.613257467969188 3.05077219560266e-05 NA NA NA hsa-let-7a-3p NCAM1 0.101609552389411 0.646619196813319 -0.211076048597993 0.535340977623261 miRNATAP -0.609340379030434 5.46665932846602e-06 NA NA NA hsa-let-7a-3p NECAB1 0.101609552389411 0.646619196813319 -0.540722662100603 0.044670956538922 MirTarget;miRNATAP -0.705695427095752 5.64826223962848e-12 NA NA NA hsa-let-7a-3p NEDD4 0.101609552389411 0.646619196813319 0.621367743960735 0.000688617498729233 mirMAP -0.178051103060118 0.00479882828862927 NA NA NA hsa-let-7a-3p NEK7 0.101609552389411 0.646619196813319 -0.023742795907272 0.885863545264543 mirMAP -0.127336180301948 0.00186058242584064 NA NA NA hsa-let-7a-3p NFASC 0.101609552389411 0.646619196813319 -0.0558333602961598 0.843443378029976 miRNATAP -0.381670905529763 0.000606558848701117 NA NA NA hsa-let-7a-3p NFIC 0.101609552389411 0.646619196813319 -0.415962973407169 0.0237327291321855 miRNATAP -0.145053153749338 0.0242803535160173 NA NA NA hsa-let-7a-3p NLGN1 0.101609552389411 0.646619196813319 -0.968049704831492 0.0260376960589066 MirTarget;miRNATAP -0.998736412512457 3.34920193715702e-10 NA NA NA hsa-let-7a-3p NOVA1 0.101609552389411 0.646619196813319 -0.68631962750184 0.0863393640001367 miRNATAP -0.579514042843343 0.000212566285912952 NA NA NA hsa-let-7a-3p NPR3 0.101609552389411 0.646619196813319 -0.962297072093226 0.0364746261537283 MirTarget;miRNATAP -0.994012113925742 1.97867017777095e-08 NA NA NA hsa-let-7a-3p NPY1R 0.101609552389411 0.646619196813319 0.272404918196811 0.575288997665912 miRNATAP -0.483651095498001 0.0124516950113744 NA NA NA hsa-let-7a-3p NR3C1 0.101609552389411 0.646619196813319 -0.635847836907233 0.00672924087351273 miRNATAP -0.505663275611618 7.45995353938247e-09 NA NA NA hsa-let-7a-3p NR4A3 0.101609552389411 0.646619196813319 -0.227518666679225 0.46744510318868 mirMAP -0.393965430664077 0.00133750983452919 NA NA NA hsa-let-7a-3p NRP1 0.101609552389411 0.646619196813319 -0.578987852770826 0.0121680377725486 miRNATAP -0.469192021502807 4.76146272015568e-09 NA NA NA hsa-let-7a-3p NRP2 0.101609552389411 0.646619196813319 -0.505877122994509 0.0510882277736963 miRNATAP -0.588403944571623 1.85499682046752e-10 NA NA NA hsa-let-7a-3p NRXN1 0.101609552389411 0.646619196813319 -0.699147396056496 0.171752034214891 MirTarget;miRNATAP -1.18923071949819 5.29554085336768e-10 NA NA NA hsa-let-7a-3p NTN4 0.101609552389411 0.646619196813319 -0.503196474342153 0.0152160064565671 MirTarget -0.165943659394208 0.0319335680143832 NA NA NA hsa-let-7a-3p NTRK3 0.101609552389411 0.646619196813319 -0.0427330401773474 0.91242513287602 mirMAP -0.769711898091584 2.05674928401949e-07 NA NA NA hsa-let-7a-3p OLFML2B 0.101609552389411 0.646619196813319 -0.466119908625237 0.0767330115496027 MirTarget;miRNATAP -0.588552633292754 9.10416222275103e-10 NA NA NA hsa-let-7a-3p OSBPL8 0.101609552389411 0.646619196813319 -0.231836824746721 0.158164796155622 mirMAP;miRNATAP -0.129490865707288 0.00134964936357086 NA NA NA hsa-let-7a-3p OXR1 0.101609552389411 0.646619196813319 0.280481632622279 0.1005398666169 MirTarget;miRNATAP -0.133246372649334 0.00557193352620917 NA NA NA hsa-let-7a-3p PAFAH1B2 0.101609552389411 0.646619196813319 -0.0872222814097938 0.537190554994653 mirMAP -0.171554825132389 6.13823332693532e-05 NA NA NA hsa-let-7a-3p PCDH17 0.101609552389411 0.646619196813319 -0.399945475564735 0.05748852604357 miRNATAP -0.385803158347146 1.38014101436631e-06 NA NA NA hsa-let-7a-3p PCDH19 0.101609552389411 0.646619196813319 0.413009510963433 0.363744681468748 miRNATAP -0.423595138615953 0.0199405807093135 NA NA NA hsa-let-7a-3p PCDH7 0.101609552389411 0.646619196813319 -0.65020828800841 0.0286626186435334 mirMAP -0.726548432439984 1.39349595292317e-10 NA NA NA hsa-let-7a-3p PCSK2 0.101609552389411 0.646619196813319 -0.558894889393825 0.198191667422379 miRNATAP -0.676842079277183 3.30938759975244e-05 NA NA NA hsa-let-7a-3p PDE10A 0.101609552389411 0.646619196813319 -1.36229692682905 3.42278838405342e-06 mirMAP -0.315874872276348 0.00821215713619813 NA NA NA hsa-let-7a-3p PDE1C 0.101609552389411 0.646619196813319 -0.389060973951137 0.213183416840764 mirMAP -0.390199495667006 0.00119771506029023 NA NA NA hsa-let-7a-3p PDE4B 0.101609552389411 0.646619196813319 -0.85067305202513 0.0010310986002441 mirMAP -0.305530135278685 0.00243742055743648 NA NA NA hsa-let-7a-3p PDE5A 0.101609552389411 0.646619196813319 -0.920136461750414 2.65262618427252e-05 MirTarget -0.249267642957443 0.00241508410636153 NA NA NA hsa-let-7a-3p PDGFC 0.101609552389411 0.646619196813319 -0.627442138868547 0.0143652192767315 mirMAP -0.560183588702006 8.86071239448277e-09 NA NA NA hsa-let-7a-3p PDGFRA 0.101609552389411 0.646619196813319 -0.395810852325636 0.172422170010915 mirMAP -0.46804730928802 1.13954952980613e-05 NA NA NA hsa-miR-22-5p PDPK1 -0.125203579828934 0.58138479571056 0.324765736063808 0.0665375777538798 miRNATAP -0.11021672261126 0.00107500585415004 NA NA NA hsa-miR-493-5p PDPK1 -0.198709255175787 0.261271982501049 0.324765736063808 0.0665375777538798 miRNATAP -0.109752935305635 0.0110031211146919 NA NA NA hsa-let-7a-3p PDZRN3 0.101609552389411 0.646619196813319 -0.434677060113417 0.0977789820368795 miRNATAP -0.348332403637459 0.000447014170045025 NA NA NA hsa-let-7a-3p PEG10 0.101609552389411 0.646619196813319 -1.44536631308877 0.00179293055150136 mirMAP -0.520314464992891 0.00532082958672564 NA NA NA hsa-let-7a-3p PFKFB3 0.101609552389411 0.646619196813319 -0.311221199636625 0.106113200096157 MirTarget;miRNATAP -0.113814500352109 0.0258200081232623 NA NA NA hsa-miR-429 PGF 0.229346217598988 0.464802955959168 -0.311441869122028 0.116095544400189 miRNATAP -0.157730468642131 0.00280494441192971 NA NA NA hsa-let-7a-3p PGM2L1 0.101609552389411 0.646619196813319 -0.0956091551013207 0.623863202883761 mirMAP -0.173772274870734 0.0115823419416568 NA NA NA hsa-let-7a-3p PHLDB2 0.101609552389411 0.646619196813319 -0.697984789151926 0.0116893432534967 mirMAP -0.695794910477307 3.29681309455157e-11 NA NA NA hsa-let-7a-3p PI15 0.101609552389411 0.646619196813319 -0.085356193306625 0.825028292863788 MirTarget -0.438432944968582 0.00444793207113499 NA NA NA hsa-let-7f-1-3p PIK3CA 0.0232337533686442 0.882480601364687 -0.13997208465004 0.205783698813739 mirMAP -0.118501081655342 0.0064771514178073 NA NA NA hsa-miR-148a-5p PIK3CA -0.0350223755826597 0.885849057601304 -0.13997208465004 0.205783698813739 mirMAP -0.112357517651492 7.06215647986463e-05 NA NA NA hsa-miR-148b-3p PIK3CA 0.0651435695165503 0.780897929982862 -0.13997208465004 0.205783698813739 miRNAWalker2_validate -0.117892096365902 0.00490902202717801 NA NA NA hsa-miR-16-2-3p PIK3CA 0.153726329181235 0.482682863515283 -0.13997208465004 0.205783698813739 mirMAP -0.10245614796563 9.13897985797286e-05 NA NA NA hsa-miR-17-5p PIK3CA 0.654454113630718 0.0320922529414325 -0.13997208465004 0.205783698813739 miRNAWalker2_validate -0.115705723770344 3.03228335548689e-06 NA NA NA hsa-miR-186-5p PIK3CA 0.0414271542658895 0.855875332337529 -0.13997208465004 0.205783698813739 mirMAP -0.146329134056921 0.000268937701971312 NA NA NA hsa-miR-32-3p PIK3CA 0.331827826560311 0.224850265700549 -0.13997208465004 0.205783698813739 mirMAP -0.112972746252127 2.51225612643757e-08 NA NA NA hsa-miR-335-5p PIK3CA 0.677684729560542 0.00250537394966771 -0.13997208465004 0.205783698813739 miRNAWalker2_validate -0.10180509768488 9.82755134026126e-05 NA NA NA hsa-miR-339-5p PIK3CA 0.365698388272866 0.141984768333942 -0.13997208465004 0.205783698813739 miRanda -0.103587269763801 8.44655068921029e-06 NA NA NA hsa-miR-374b-5p PIK3CA 0.420828077578832 0.0368215896674663 -0.13997208465004 0.205783698813739 mirMAP -0.142766383581644 0.00032150800529493 NA NA NA hsa-miR-501-5p PIK3CA 0.384505305961809 0.132614546832124 -0.13997208465004 0.205783698813739 mirMAP -0.110757579310586 1.16330645525834e-07 NA NA NA hsa-miR-576-5p PIK3CA -0.0646836612801551 0.749193541371544 -0.13997208465004 0.205783698813739 PITA -0.113974010997229 6.59094941020168e-05 NA NA NA hsa-miR-582-3p PIK3CA -0.121819873244138 0.644524724853263 -0.13997208465004 0.205783698813739 miRNATAP -0.140113361530972 2.23178585157338e-06 NA NA NA hsa-miR-590-3p PIK3CA 0.61452706068502 0.00851921195946504 -0.13997208465004 0.205783698813739 miRanda;mirMAP -0.123897140594567 1.31301452772078e-07 NA NA NA hsa-miR-590-5p PIK3CA 0.310398056198485 0.187672587496216 -0.13997208465004 0.205783698813739 miRanda -0.140125048782077 1.41706046141534e-08 NA NA NA hsa-miR-96-5p PIK3CA 0.278190818912657 0.237980325123386 -0.13997208465004 0.205783698813739 TargetScan -0.128475980855667 9.81905908048452e-08 NA NA NA hsa-miR-1468-5p PIK3CD 0.508947387825943 0.0139364814384118 -0.51649151508193 0.0364450400507832 MirTarget -0.293090508926218 0.000248785469894942 NA NA NA hsa-miR-29a-3p PIK3CD 0.422455884388283 0.210846507695107 -0.51649151508193 0.0364450400507832 mirMAP -0.351166771873915 0.00243536234086878 NA NA NA hsa-miR-29b-3p PIK3CD 0.576937416051043 0.0425757132324386 -0.51649151508193 0.0364450400507832 mirMAP -0.263613715224296 0.00266331795083224 NA NA NA hsa-miR-30b-3p PIK3CD -0.0768471506024466 0.699454152876203 -0.51649151508193 0.0364450400507832 MirTarget -0.194812090288003 0.0235152186170438 NA NA NA hsa-miR-30b-5p PIK3CD 0.159947883339023 0.566120765663465 -0.51649151508193 0.0364450400507832 MirTarget -0.395682674717868 3.65190942130723e-06 NA NA NA hsa-miR-30c-5p PIK3CD 0.124629392123455 0.596633172133938 -0.51649151508193 0.0364450400507832 MirTarget;miRNATAP -0.419452305097446 0.000712699686404817 NA NA NA hsa-miR-30d-5p PIK3CD 0.0178116929398371 0.955537710927223 -0.51649151508193 0.0364450400507832 MirTarget;miRNATAP -0.360885227262785 0.00123008895505406 NA NA NA hsa-miR-324-5p PIK3CD 0.057242254542023 0.783617053528212 -0.51649151508193 0.0364450400507832 miRanda -0.19400350900327 0.0378875481163709 NA NA NA hsa-miR-421 PIK3CD 0.483846282376657 0.0175641163246583 -0.51649151508193 0.0364450400507832 miRanda -0.48895286723391 2.44692621373687e-09 NA NA NA hsa-miR-484 PIK3CD 0.11519428416634 0.591863978478611 -0.51649151508193 0.0364450400507832 MirTarget;miRNATAP -0.351057480112147 0.00143452196121959 NA NA NA hsa-miR-7-5p PIK3CD 0.569681462078775 0.0643718059199626 -0.51649151508193 0.0364450400507832 miRTarBase;MirTarget;miRNATAP -0.196228010352377 0.000352590199023202 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-942-5p PIK3CD 0.218353306237975 0.366221556065113 -0.51649151508193 0.0364450400507832 MirTarget -0.192312219113083 0.0086308226579878 NA NA NA hsa-miR-126-3p PIK3CG -0.012397987398181 0.966936805337043 -0.508925657665325 0.131657023717449 miRTarBase -0.534372493039168 0.000484031176443627 NA NA NA hsa-miR-26b-5p PIK3CG 0.124364243009017 0.63657079673149 -0.508925657665325 0.131657023717449 miRNAWalker2_validate -0.795245028298382 7.45064172731532e-07 NA NA NA hsa-miR-29b-3p PIK3CG 0.576937416051043 0.0425757132324386 -0.508925657665325 0.131657023717449 miRTarBase -0.666133284835925 1.9528746633095e-08 NA NA NA hsa-miR-335-3p PIK3CG 0.682801908222203 0.00891090859328538 -0.508925657665325 0.131657023717449 mirMAP -0.563949149516835 2.51672261116185e-07 NA NA NA hsa-miR-421 PIK3CG 0.483846282376657 0.0175641163246583 -0.508925657665325 0.131657023717449 miRanda -0.444524915857051 0.000133233454665448 NA NA NA hsa-miR-502-5p PIK3CG 0.0640287093715612 0.786573915467216 -0.508925657665325 0.131657023717449 miRNATAP -0.340480467784473 0.000652722824953133 26163264 Phosphoinositide 3-kinase catalytic subunit gamma PIK3CG was identified as a direct downstream target of miR-502 in HCC cells; Notably overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells liver cancer hsa-miR-590-3p PIK3CG 0.61452706068502 0.00851921195946504 -0.508925657665325 0.131657023717449 miRanda -0.438492197588501 1.39596666922937e-05 NA NA NA hsa-miR-107 PIK3R1 0.0279960669519728 0.920212407969573 0.00821710793606378 0.963821253916958 MirTarget;PITA;miRanda;miRNATAP -0.159578315724103 0.0420240332899534 NA NA NA hsa-miR-132-3p PIK3R1 -0.172232001969051 0.395197692768507 0.00821710793606378 0.963821253916958 MirTarget -0.191363026291576 0.00729852053203983 NA NA NA hsa-miR-15a-5p PIK3R1 0.211823319622055 0.34754443857672 0.00821710793606378 0.963821253916958 MirTarget -0.217108462406312 8.91731617861317e-05 NA NA NA hsa-miR-15b-5p PIK3R1 0.101141961851801 0.680859173657598 0.00821710793606378 0.963821253916958 MirTarget -0.14300320532504 0.00643583854060318 NA NA NA hsa-miR-16-5p PIK3R1 0.145487293472948 0.590284028672631 0.00821710793606378 0.963821253916958 MirTarget -0.189731088951203 0.0002621971143127 NA NA NA hsa-miR-185-5p PIK3R1 -0.0751971031831333 0.701935318001601 0.00821710793606378 0.963821253916958 miRNATAP -0.23627908813405 0.00027005032337405 NA NA NA hsa-miR-199a-3p PIK3R1 -0.0160303466656302 0.958287982173013 0.00821710793606378 0.963821253916958 miRNATAP -0.114702369631033 0.0400244018594487 NA NA NA hsa-miR-199b-3p PIK3R1 -0.0162230733501865 0.957783927951859 0.00821710793606378 0.963821253916958 miRNATAP -0.114742586941786 0.0399527963725661 NA NA NA hsa-miR-21-5p PIK3R1 -0.0799831466796448 0.848619631369434 0.00821710793606378 0.963821253916958 miRNAWalker2_validate;MirTarget;miRNATAP -0.32048586087571 3.69693869528844e-05 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.0183627935055273 0.916715705666675 0.00821710793606378 0.963821253916958 MirTarget -0.229364822725893 5.39528810633945e-05 NA NA NA hsa-miR-22-5p PIK3R1 -0.125203579828934 0.58138479571056 0.00821710793606378 0.963821253916958 mirMAP -0.186145388676108 2.66965799007355e-05 NA NA NA hsa-miR-221-3p PIK3R1 0.534505400399477 0.0267387070367555 0.00821710793606378 0.963821253916958 MirTarget -0.197435928682178 0.000527618156345501 NA NA NA hsa-miR-222-3p PIK3R1 0.439345927129621 0.0506051179685588 0.00821710793606378 0.963821253916958 MirTarget -0.202803725155249 6.41878654683067e-05 NA NA NA hsa-miR-369-3p PIK3R1 0.135995136901538 0.499460414151147 0.00821710793606378 0.963821253916958 PITA -0.167895129809982 0.000380018195201003 NA NA NA hsa-miR-424-5p PIK3R1 0.362472054054227 0.208698146989944 0.00821710793606378 0.963821253916958 MirTarget -0.119382000204097 0.00203768025896863 NA NA NA hsa-miR-450b-5p PIK3R1 0.00436780818154059 0.982506709891873 0.00821710793606378 0.963821253916958 miRNATAP -0.190787246019265 6.82791616588e-05 NA NA NA hsa-miR-542-3p PIK3R1 0.127210989834333 0.600058785518928 0.00821710793606378 0.963821253916958 MirTarget;PITA;miRanda -0.150969723974234 0.00748950466389255 NA NA NA hsa-miR-548o-3p PIK3R1 0.287494379071396 0.191813664384868 0.00821710793606378 0.963821253916958 mirMAP -0.106039985326561 0.0124895472954661 NA NA NA hsa-miR-582-5p PIK3R1 -0.228254145294111 0.237411325958129 0.00821710793606378 0.963821253916958 mirMAP -0.142451077115944 0.0045721005781701 NA NA NA hsa-miR-590-3p PIK3R1 0.61452706068502 0.00851921195946504 0.00821710793606378 0.963821253916958 miRanda;mirMAP -0.146401290926594 0.000138874186663878 NA NA NA hsa-miR-590-5p PIK3R1 0.310398056198485 0.187672587496216 0.00821710793606378 0.963821253916958 MirTarget;PITA;miRanda;miRNATAP -0.15721405103923 0.000108223764424085 NA NA NA hsa-miR-30a-5p PIK3R2 -0.045302777291603 0.880974166508925 0.14811360638475 0.416122517480467 miRNATAP -0.205862820761505 5.83465711487357e-06 NA NA NA hsa-miR-181c-5p PIK3R3 0.31948559060922 0.126696663734917 -0.183017556622773 0.326624551945699 MirTarget;miRNATAP -0.166375015135553 0.00307339705460455 NA NA NA hsa-miR-181d-5p PIK3R3 0.766382344176968 0.00141892473589568 -0.183017556622773 0.326624551945699 MirTarget -0.160008098502222 0.000261018045617695 NA NA NA hsa-miR-19a-3p PIK3R3 0.492121782019476 0.0512469162191149 -0.183017556622773 0.326624551945699 MirTarget;miRNATAP -0.116147528359031 0.00952170048888319 NA NA NA hsa-miR-19b-3p PIK3R3 0.54121896996679 0.0308428363133693 -0.183017556622773 0.326624551945699 MirTarget;miRNATAP -0.194729521448902 0.000250390771046988 NA NA NA hsa-miR-32-5p PIK3R3 0.39311392840132 0.0808851684771013 -0.183017556622773 0.326624551945699 MirTarget;miRNATAP -0.138065839958076 0.00869251602983598 NA NA NA hsa-miR-335-3p PIK3R3 0.682801908222203 0.00891090859328538 -0.183017556622773 0.326624551945699 mirMAP -0.200911178812086 3.4951167686824e-05 NA NA NA hsa-miR-339-5p PIK3R3 0.365698388272866 0.141984768333942 -0.183017556622773 0.326624551945699 MirTarget;miRanda -0.114440753951127 0.00949514702310638 NA NA NA hsa-miR-454-3p PIK3R3 0.493936490517753 0.00397224628288767 -0.183017556622773 0.326624551945699 mirMAP -0.183582040707033 0.00426750044797469 NA NA NA hsa-miR-590-5p PIK3R3 0.310398056198485 0.187672587496216 -0.183017556622773 0.326624551945699 miRanda -0.117849359871163 0.0132046234736956 NA NA NA hsa-miR-92a-3p PIK3R3 0.672816611409429 0.0718964206294189 -0.183017556622773 0.326624551945699 MirTarget;miRNATAP -0.264671393069774 1.12229021521678e-06 NA NA NA hsa-miR-182-5p PIK3R5 0.21979085714211 0.550790825020532 -0.734718113926991 0.00817976158333349 MirTarget -0.335738588315792 0.000137422868989864 NA NA NA hsa-miR-18a-3p PIK3R5 0.537097022881074 0.0391294371382267 -0.734718113926991 0.00817976158333349 MirTarget -0.247792416366587 0.000674544930154222 NA NA NA hsa-let-7a-3p PJA2 0.101609552389411 0.646619196813319 -0.0327011088084408 0.853995695136466 MirTarget;mirMAP -0.178462987095895 3.42605793795789e-05 NA NA NA hsa-let-7a-3p PLA2R1 0.101609552389411 0.646619196813319 0.315180397137874 0.196657490794191 mirMAP -0.19721378029766 0.0361205241459697 NA NA NA hsa-let-7a-3p PLCL1 0.101609552389411 0.646619196813319 -0.274397853659629 0.147934389095087 mirMAP -0.441531564239423 1.75776315087487e-09 NA NA NA hsa-let-7a-3p PLXDC1 0.101609552389411 0.646619196813319 -0.276507516020107 0.15282460935903 mirMAP -0.353676295490288 7.40749147743929e-07 NA NA NA hsa-let-7a-3p PLXNA4 0.101609552389411 0.646619196813319 -0.802953713681785 0.0310863662339689 miRNATAP -0.895125888135038 5.76001265551055e-10 NA NA NA hsa-let-7a-3p POLK 0.101609552389411 0.646619196813319 0.091011630146161 0.456601383457971 MirTarget -0.122480793478035 0.000107261754731944 NA NA NA hsa-let-7a-3p PPM1K 0.101609552389411 0.646619196813319 -0.288467070385875 0.110871804146258 MirTarget -0.211349638742289 0.00323721678058101 NA NA NA hsa-let-7a-3p PPP1R12A 0.101609552389411 0.646619196813319 -0.092995231343326 0.541693673624803 mirMAP;miRNATAP -0.112334081980534 0.000143326741796444 NA NA NA hsa-let-7a-3p PPP1R3F 0.101609552389411 0.646619196813319 0.222929149007445 0.255659303905747 MirTarget;miRNATAP -0.193174870934325 0.0128110532450715 NA NA NA hsa-let-7a-3p PRDM1 0.101609552389411 0.646619196813319 -0.24384351959073 0.245699548714685 mirMAP -0.168109530894074 0.0180307506803804 20651244 Data obtained from expression analysis luciferase reporter assays and transfection experiments support a role of targeting of PRDM1 by microRNA let-7 family in mediating this down-regulation B cell lymphoma hsa-let-7a-3p PRICKLE2 0.101609552389411 0.646619196813319 -0.124409793749501 0.599882968689728 mirMAP -0.486808759656843 6.22651748439903e-08 NA NA NA hsa-miR-101-3p PRKAA1 0.0629937163023246 0.844386980576976 0.0475537408513969 0.785439080590329 MirTarget;miRNATAP -0.16917213844282 0.000159540976904725 NA NA NA hsa-miR-126-5p PRKAA1 -0.145191729940198 0.522781436391604 0.0475537408513969 0.785439080590329 mirMAP -0.182966892379109 1.6097058628994e-06 NA NA NA hsa-miR-130a-3p PRKAA1 0.026181550942697 0.906953517484668 0.0475537408513969 0.785439080590329 MirTarget;miRNATAP -0.175002779933657 7.72068997440457e-09 NA NA NA hsa-miR-142-5p PRKAA1 0.0206835709056703 0.935321422316443 0.0475537408513969 0.785439080590329 PITA;mirMAP -0.101476180651905 0.000168308839474968 NA NA NA hsa-miR-146b-3p PRKAA1 -0.319493995064978 0.163980882060085 0.0475537408513969 0.785439080590329 MirTarget;PITA;miRNATAP -0.10166543186724 0.00175087926243424 NA NA NA hsa-miR-152-3p PRKAA1 -0.139722053542437 0.54041139794059 0.0475537408513969 0.785439080590329 MirTarget -0.195684681215086 0.000166794973895574 NA NA NA hsa-miR-154-3p PRKAA1 -0.154959161031151 0.456222338450225 0.0475537408513969 0.785439080590329 MirTarget -0.137022353605923 1.74925797229127e-06 NA NA NA hsa-miR-30a-5p PRKAA1 -0.045302777291603 0.880974166508925 0.0475537408513969 0.785439080590329 miRNAWalker2_validate -0.161862346655212 0.000407673853300811 NA NA NA hsa-miR-495-3p PRKAA1 -0.120132958670248 0.475560073783891 0.0475537408513969 0.785439080590329 mirMAP -0.134239921630036 0.000389251864412267 NA NA NA hsa-miR-497-5p PRKAA1 0.0588593222857097 0.74974374041188 0.0475537408513969 0.785439080590329 MirTarget -0.129214261225063 0.000426095257692293 NA NA NA hsa-let-7a-3p PRKAA2 0.101609552389411 0.646619196813319 -0.64825721324167 0.210200033487094 mirMAP -0.507574456403945 0.0144169189688624 NA NA NA hsa-let-7a-5p PRKAA2 -0.027295465689507 0.936065233950454 -0.64825721324167 0.210200033487094 MirTarget;TargetScan -1.3774349277681 4.40575800230604e-05 NA NA NA hsa-let-7b-3p PRKAA2 -0.108588843151252 0.563943167467051 -0.64825721324167 0.210200033487094 mirMAP -0.681359549278188 0.00864082451249208 NA NA NA hsa-let-7d-5p PRKAA2 0.180687618914645 0.407153023455971 -0.64825721324167 0.210200033487094 MirTarget -1.0808124464292 0.000340967407233226 NA NA NA hsa-let-7f-1-3p PRKAA2 0.0232337533686442 0.882480601364687 -0.64825721324167 0.210200033487094 mirMAP -1.04475655583997 0.000198126659587119 NA NA NA hsa-let-7f-5p PRKAA2 0.298975996701252 0.358142291880245 -0.64825721324167 0.210200033487094 MirTarget -1.25748553533529 1.06108331603952e-05 NA NA NA hsa-let-7g-5p PRKAA2 0.277737429324977 0.265837688072841 -0.64825721324167 0.210200033487094 MirTarget -1.48951694235668 2.21507457470249e-07 NA NA NA hsa-miR-106b-5p PRKAA2 0.284551111571426 0.277367924981826 -0.64825721324167 0.210200033487094 mirMAP -0.749379041166482 0.00045170381035773 NA NA NA hsa-miR-10a-5p PRKAA2 0.263348367388893 0.529788179364853 -0.64825721324167 0.210200033487094 MirTarget -0.485307367052801 0.0067774444725377 NA NA NA hsa-miR-130b-3p PRKAA2 0.426186909383556 0.0535253475456448 -0.64825721324167 0.210200033487094 MirTarget -0.588519017811155 0.00220222230221989 NA NA NA hsa-miR-141-3p PRKAA2 0.375303508996668 0.23369759511523 -0.64825721324167 0.210200033487094 mirMAP -0.7237523018411 3.63348108517845e-06 NA NA NA hsa-miR-142-5p PRKAA2 0.0206835709056703 0.935321422316443 -0.64825721324167 0.210200033487094 mirMAP -0.339346197170225 0.0447757487556072 NA NA NA hsa-miR-144-3p PRKAA2 -0.142730993896132 0.649187086987658 -0.64825721324167 0.210200033487094 mirMAP -0.282691605367235 0.0131329800749971 NA NA NA hsa-miR-146a-5p PRKAA2 0.272429077688215 0.354588868257395 -0.64825721324167 0.210200033487094 MirTarget -0.879161706521282 9.81298624966043e-09 NA NA NA hsa-miR-146b-5p PRKAA2 -0.172983582782209 0.520789483760829 -0.64825721324167 0.210200033487094 MirTarget -0.424197105515651 0.04711315472271 NA NA NA hsa-miR-150-3p PRKAA2 -0.345022190620201 0.254787378658924 -0.64825721324167 0.210200033487094 MirTarget;miRNATAP -0.279507143123438 0.0196914419064455 NA NA NA hsa-miR-15b-3p PRKAA2 0.253700501723044 0.258816254433513 -0.64825721324167 0.210200033487094 mirMAP -0.952477585223996 4.39269041503324e-07 NA NA NA hsa-miR-16-2-3p PRKAA2 0.153726329181235 0.482682863515283 -0.64825721324167 0.210200033487094 mirMAP -0.849296279638287 4.44189322821268e-07 NA NA NA hsa-miR-17-5p PRKAA2 0.654454113630718 0.0320922529414325 -0.64825721324167 0.210200033487094 mirMAP -0.560187125590358 0.000582130294131559 NA NA NA hsa-miR-181a-2-3p PRKAA2 -0.012214802083232 0.962259436543774 -0.64825721324167 0.210200033487094 mirMAP -0.493301127620791 0.0272582398785297 NA NA NA hsa-miR-182-5p PRKAA2 0.21979085714211 0.550790825020532 -0.64825721324167 0.210200033487094 miRNAWalker2_validate;MirTarget;mirMAP -0.662775728142482 4.86187881504762e-05 NA NA NA hsa-miR-186-5p PRKAA2 0.0414271542658895 0.855875332337529 -0.64825721324167 0.210200033487094 MirTarget -1.22340801207465 2.16812724466492e-06 NA NA NA hsa-miR-192-5p PRKAA2 0.645545829765007 0.1251330842899 -0.64825721324167 0.210200033487094 miRNAWalker2_validate -0.733473079800383 4.27906815146448e-07 NA NA NA hsa-miR-19a-3p PRKAA2 0.492121782019476 0.0512469162191149 -0.64825721324167 0.210200033487094 mirMAP -0.46168551044351 0.00296159285257802 NA NA NA hsa-miR-19b-3p PRKAA2 0.54121896996679 0.0308428363133693 -0.64825721324167 0.210200033487094 mirMAP -0.418519903176696 0.0249338993973771 NA NA NA hsa-miR-200a-3p PRKAA2 0.0859962582412201 0.779813959770487 -0.64825721324167 0.210200033487094 mirMAP -0.482675549448898 0.00174597157504641 NA NA NA hsa-miR-200b-3p PRKAA2 0.155726849405916 0.625900255789875 -0.64825721324167 0.210200033487094 MirTarget -0.798327128385879 9.24163890589522e-06 NA NA NA hsa-miR-200c-3p PRKAA2 0.312679230647506 0.396034062318706 -0.64825721324167 0.210200033487094 MirTarget -0.869431098545426 2.52925399045918e-06 NA NA NA hsa-miR-203a-3p PRKAA2 0.401351277657477 0.308555610867652 -0.64825721324167 0.210200033487094 MirTarget -0.527289239158294 0.000135284378990592 NA NA NA hsa-miR-20a-5p PRKAA2 0.575987288988369 0.0504195522708827 -0.64825721324167 0.210200033487094 mirMAP -0.529658710106026 0.000975267278142125 NA NA NA hsa-miR-21-3p PRKAA2 0.0611954235279129 0.844344100715466 -0.64825721324167 0.210200033487094 mirMAP -1.03899726703384 2.04856179048105e-06 NA NA NA hsa-miR-23a-3p PRKAA2 0.0793483791702947 0.782251726363025 -0.64825721324167 0.210200033487094 mirMAP -1.04156287853583 0.00263446744436447 NA NA NA hsa-miR-26a-1-3p PRKAA2 0.148378165983399 0.5428772192612 -0.64825721324167 0.210200033487094 mirMAP -0.831931348543817 1.11599255200588e-07 NA NA NA hsa-miR-26a-2-3p PRKAA2 0.600599658178176 0.00466561488298205 -0.64825721324167 0.210200033487094 mirMAP -0.621925972203779 0.000208611065818212 NA NA NA hsa-miR-26b-5p PRKAA2 0.124364243009017 0.63657079673149 -0.64825721324167 0.210200033487094 mirMAP -0.877919448261694 0.000414963955029203 NA NA NA hsa-miR-30c-5p PRKAA2 0.124629392123455 0.596633172133938 -0.64825721324167 0.210200033487094 MirTarget -0.558651346330939 0.0346225455412429 NA NA NA hsa-miR-30e-3p PRKAA2 0.085752496440028 0.77719439827986 -0.64825721324167 0.210200033487094 MirTarget -1.53784464149708 5.63409730084565e-06 NA NA NA hsa-miR-30e-5p PRKAA2 0.158090590539706 0.584574122071174 -0.64825721324167 0.210200033487094 MirTarget -0.773980270542683 0.00794921376751559 NA NA NA hsa-miR-32-3p PRKAA2 0.331827826560311 0.224850265700549 -0.64825721324167 0.210200033487094 MirTarget -0.481495573207177 0.000342223690957318 NA NA NA hsa-miR-331-3p PRKAA2 -0.0885650120017627 0.673797290031959 -0.64825721324167 0.210200033487094 MirTarget -0.559581244175645 0.005382842440452 NA NA NA hsa-miR-335-3p PRKAA2 0.682801908222203 0.00891090859328538 -0.64825721324167 0.210200033487094 MirTarget -0.475040463884501 0.00535237454693503 NA NA NA hsa-miR-338-5p PRKAA2 -0.273779892203874 0.300287346243028 -0.64825721324167 0.210200033487094 mirMAP -0.436365295570795 0.00124419268010689 NA NA NA hsa-miR-33a-3p PRKAA2 0.0801132536031662 0.726683004542423 -0.64825721324167 0.210200033487094 mirMAP -0.78140196136191 4.75819311035266e-07 NA NA NA hsa-miR-340-5p PRKAA2 0.0370561016519786 0.847255543644633 -0.64825721324167 0.210200033487094 MirTarget -0.803611072578256 0.000220849274859537 NA NA NA hsa-miR-34a-5p PRKAA2 0.0429690664173119 0.863416991446736 -0.64825721324167 0.210200033487094 miRNATAP -0.680721001282327 0.00062567886812767 NA NA NA hsa-miR-374a-3p PRKAA2 0.470782121977866 0.115478461254988 -0.64825721324167 0.210200033487094 mirMAP -0.470760399439363 0.0119461388556633 NA NA NA hsa-miR-429 PRKAA2 0.229346217598988 0.464802955959168 -0.64825721324167 0.210200033487094 MirTarget;miRNATAP -0.451648244320967 0.0022054440219677 NA NA NA hsa-miR-500a-5p PRKAA2 0.337308544937691 0.141131366250697 -0.64825721324167 0.210200033487094 mirMAP -0.525095995468797 0.00097684748463756 NA NA NA hsa-miR-576-5p PRKAA2 -0.0646836612801551 0.749193541371544 -0.64825721324167 0.210200033487094 mirMAP -0.958548116562417 1.67327435907317e-07 NA NA NA hsa-miR-577 PRKAA2 -0.131565620416609 0.724256245908512 -0.64825721324167 0.210200033487094 MirTarget;PITA;miRNATAP -0.409987394244555 1.96607711933672e-05 NA NA NA hsa-miR-582-5p PRKAA2 -0.228254145294111 0.237411325958129 -0.64825721324167 0.210200033487094 mirMAP -0.704031452597596 0.000475991710003507 NA NA NA hsa-miR-589-5p PRKAA2 0.0783585826497797 0.689867541769585 -0.64825721324167 0.210200033487094 MirTarget -1.28590342765677 3.25819586564613e-07 NA NA NA hsa-miR-590-3p PRKAA2 0.61452706068502 0.00851921195946504 -0.64825721324167 0.210200033487094 mirMAP;miRNATAP -0.666306737006168 1.53913852506846e-05 NA NA NA hsa-miR-7-1-3p PRKAA2 -0.0548495194389744 0.804425982450317 -0.64825721324167 0.210200033487094 MirTarget;mirMAP -0.986105071845591 3.13495463371211e-08 NA NA NA hsa-miR-93-5p PRKAA2 0.240698477893627 0.478488479349248 -0.64825721324167 0.210200033487094 mirMAP -0.860546653362638 1.76855487703335e-05 NA NA NA hsa-miR-96-5p PRKAA2 0.278190818912657 0.237980325123386 -0.64825721324167 0.210200033487094 TargetScan -0.620424271055102 9.49537216168755e-05 NA NA NA hsa-miR-98-5p PRKAA2 0.383145783111506 0.0578745473335408 -0.64825721324167 0.210200033487094 miRNAWalker2_validate;MirTarget -0.521747265198128 0.0404493729890205 NA NA NA hsa-let-7a-3p PRKAR2A 0.101609552389411 0.646619196813319 0.213866021526698 0.206302497359457 mirMAP -0.145915448238501 0.0139295907063592 NA NA NA hsa-let-7a-3p PRKAR2B 0.101609552389411 0.646619196813319 -0.652197286075325 0.0301280994460668 mirMAP -0.321301677507322 0.00677085783389006 NA NA NA hsa-let-7a-3p PSD3 0.101609552389411 0.646619196813319 -0.293972749469185 0.137723716230162 MirTarget;miRNATAP -0.17228385509562 0.0133993656020313 NA NA NA hsa-let-7a-3p PTCH1 0.101609552389411 0.646619196813319 0.176531274165615 0.419579669107736 MirTarget;miRNATAP -0.167705355197575 0.0281677741866561 NA NA NA hsa-let-7a-3p PTPRB 0.101609552389411 0.646619196813319 -0.128167305316314 0.41603929288401 mirMAP -0.102797964816708 0.0225017479596649 NA NA NA hsa-let-7a-3p QKI 0.101609552389411 0.646619196813319 -0.478944595576066 0.0296760862329705 mirMAP -0.509767980450145 5.19639338318079e-11 NA NA NA hsa-let-7a-3p RAB11FIP2 0.101609552389411 0.646619196813319 0.320689445688254 0.0282012104833732 MirTarget;miRNATAP -0.103182666262478 0.0269469410966921 NA NA NA hsa-let-7a-3p RAB23 0.101609552389411 0.646619196813319 -0.102472484076903 0.521472607228999 mirMAP -0.268446840071255 2.22659706281036e-07 NA NA NA hsa-let-7a-3p RAB31 0.101609552389411 0.646619196813319 -0.62045944928514 0.0263310460949734 mirMAP -0.609338819826707 9.92611983432597e-10 NA NA NA hsa-let-7a-3p RAB33A 0.101609552389411 0.646619196813319 -0.339828219539324 0.0699527839304794 MirTarget;miRNATAP -0.293072114898934 5.38976163933812e-05 NA NA NA hsa-let-7a-3p RAB6B 0.101609552389411 0.646619196813319 -0.584109011906771 0.00844924330193063 miRNATAP -0.219824543105481 0.0121361341265997 NA NA NA hsa-let-7a-3p RAB8B 0.101609552389411 0.646619196813319 -0.251500751703371 0.0884855552254756 mirMAP -0.172877174339944 0.000183708230543847 NA NA NA hsa-let-7a-3p RASGRF2 0.101609552389411 0.646619196813319 -0.345779327739062 0.156539267393684 mirMAP -0.28208123010843 0.00318414737558839 NA NA NA hsa-let-7a-3p RBMS3 0.101609552389411 0.646619196813319 -0.306767816618671 0.27378487250439 MirTarget -0.668266281480713 2.64894709044835e-10 NA NA NA hsa-let-7a-3p RCAN2 0.101609552389411 0.646619196813319 -0.409191349663661 0.0506992495102579 miRNATAP -0.376492942341688 2.75067242193582e-06 NA NA NA hsa-let-7a-3p REST 0.101609552389411 0.646619196813319 -0.0755706948704442 0.606813080496091 mirMAP -0.22812336132548 1.9821952237143e-05 NA NA NA hsa-miR-142-3p RHEB 0.138202987615315 0.672554936747315 0.241447235010256 0.169826775389578 MirTarget;PITA;miRanda;miRNATAP -0.100218439588093 0.000176553474997339 NA NA NA hsa-miR-155-5p RHEB -0.0328198973269682 0.903293156597456 0.241447235010256 0.169826775389578 miRNAWalker2_validate;miRNATAP -0.117250793253776 0.000276574591106519 NA NA NA hsa-miR-330-3p RHEB -0.136919655814893 0.449679388202067 0.241447235010256 0.169826775389578 MirTarget -0.119171087374429 0.0008998989811971 NA NA NA hsa-miR-744-5p RHEB -0.271687520435997 0.173115204197425 0.241447235010256 0.169826775389578 miRNAWalker2_validate -0.141429247323005 0.000155814698761217 NA NA NA hsa-let-7a-3p RIC3 0.101609552389411 0.646619196813319 -0.0892884796347939 0.829594724859863 mirMAP -0.984079207110811 1.60289180186838e-10 NA NA NA hsa-miR-185-5p RICTOR -0.0751971031831333 0.701935318001601 0.0274129811366963 0.837013642514516 MirTarget -0.142788598767934 0.000260516081204663 NA NA NA hsa-let-7a-3p RIMKLB 0.101609552389411 0.646619196813319 -0.443578235599559 0.0658995859777382 MirTarget -0.408368222260354 1.52776513038736e-05 NA NA NA hsa-let-7a-3p RNF144A 0.101609552389411 0.646619196813319 -0.317835917147621 0.110667052591424 MirTarget;miRNATAP -0.205790467835725 0.00568167500358189 NA NA NA hsa-let-7a-3p ROCK1 0.101609552389411 0.646619196813319 -0.347948311397225 0.019293854891205 MirTarget -0.109897922952036 0.00727315012848761 NA NA NA hsa-let-7a-3p ROCK2 0.101609552389411 0.646619196813319 0.23348099784084 0.209854016194067 mirMAP -0.126136801448212 0.0129350218758083 NA NA NA hsa-let-7a-3p ROR1 0.101609552389411 0.646619196813319 -0.33952617818524 0.350635623203192 MirTarget -0.601907005323522 2.71543200071067e-05 NA NA NA hsa-let-7a-3p RORA 0.101609552389411 0.646619196813319 -0.222024609231557 0.331708478664029 MirTarget;mirMAP;miRNATAP -0.473632490078204 4.16603006656984e-08 NA NA NA hsa-miR-125b-5p RPS6KA1 -0.264179368065651 0.382703105610114 -0.111929579770313 0.598502710879241 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.104692452263428 0.00316337364320319 NA NA NA hsa-miR-130b-5p RPS6KA2 0.243646141917986 0.256354237638098 -0.617250894123295 0.00158970832816556 mirMAP -0.237129844458253 4.28134622117221e-05 NA NA NA hsa-miR-17-5p RPS6KA2 0.654454113630718 0.0320922529414325 -0.617250894123295 0.00158970832816556 TargetScan -0.322091991246309 2.68236808023537e-10 NA NA NA hsa-miR-192-3p RPS6KA2 0.562339332069419 0.0364908843891984 -0.617250894123295 0.00158970832816556 mirMAP -0.21084870860232 5.23989178637473e-05 NA NA NA hsa-miR-19a-3p RPS6KA2 0.492121782019476 0.0512469162191149 -0.617250894123295 0.00158970832816556 MirTarget -0.219108480961429 9.99020555334909e-06 NA NA NA hsa-miR-19b-3p RPS6KA2 0.54121896996679 0.0308428363133693 -0.617250894123295 0.00158970832816556 MirTarget -0.23593272770493 7.51165325179059e-05 NA NA NA hsa-miR-200b-3p RPS6KA2 0.155726849405916 0.625900255789875 -0.617250894123295 0.00158970832816556 TargetScan -0.194019240910741 0.000960143019653143 NA NA NA hsa-miR-200c-3p RPS6KA2 0.312679230647506 0.396034062318706 -0.617250894123295 0.00158970832816556 miRNATAP -0.282574345530705 2.19834143913116e-06 NA NA NA hsa-miR-21-3p RPS6KA2 0.0611954235279129 0.844344100715466 -0.617250894123295 0.00158970832816556 MirTarget -0.198665091022652 0.00573225230895362 NA NA NA hsa-miR-26b-5p RPS6KA2 0.124364243009017 0.63657079673149 -0.617250894123295 0.00158970832816556 miRNATAP -0.239424054062088 0.00300670275952105 NA NA NA hsa-miR-30b-5p RPS6KA2 0.159947883339023 0.566120765663465 -0.617250894123295 0.00158970832816556 MirTarget -0.123760057280884 0.0378463626758033 NA NA NA hsa-miR-30d-5p RPS6KA2 0.0178116929398371 0.955537710927223 -0.617250894123295 0.00158970832816556 MirTarget;miRNATAP -0.191826172114112 0.0124401716690486 NA NA NA hsa-miR-335-5p RPS6KA2 0.677684729560542 0.00250537394966771 -0.617250894123295 0.00158970832816556 miRNAWalker2_validate -0.234060431596672 1.8691081521659e-05 NA NA NA hsa-miR-378a-3p RPS6KA2 0.239256639521686 0.336579015916978 -0.617250894123295 0.00158970832816556 MirTarget -0.178789803986197 0.00761323264211398 NA NA NA hsa-miR-429 RPS6KA2 0.229346217598988 0.464802955959168 -0.617250894123295 0.00158970832816556 miRanda;miRNATAP -0.206097726708926 1.23988984742847e-05 NA NA NA hsa-miR-532-3p RPS6KA2 0.168579225608838 0.494753373369712 -0.617250894123295 0.00158970832816556 MirTarget;mirMAP -0.197693517146467 0.000256173580681376 NA NA NA hsa-miR-589-5p RPS6KA2 0.0783585826497797 0.689867541769585 -0.617250894123295 0.00158970832816556 mirMAP -0.382143397432093 2.9387875425604e-06 NA NA NA hsa-miR-592 RPS6KA2 1.86717823603616 2.16983885695828e-05 -0.617250894123295 0.00158970832816556 mirMAP -0.138240930675091 2.37329786569536e-08 NA NA NA hsa-miR-760 RPS6KA2 0.246485338481877 0.379052094504744 -0.617250894123295 0.00158970832816556 MirTarget -0.165249753535965 5.87948360312009e-05 NA NA NA hsa-miR-93-3p RPS6KA2 0.137729603708961 0.520300877886587 -0.617250894123295 0.00158970832816556 MirTarget -0.166388356178872 0.00445122133838709 NA NA NA hsa-let-7b-5p RPS6KA3 -0.070402569509616 0.831170990756357 0.172322385426185 0.363981729108367 miRNATAP -0.113587616864783 0.0341410769709952 NA NA NA hsa-let-7e-5p RPS6KA3 -0.154600397322309 0.544003735687883 0.172322385426185 0.363981729108367 miRNATAP -0.220355153590709 0.000102788838680634 NA NA NA hsa-let-7i-5p RPS6KA3 -0.0507931764168728 0.836792334788736 0.172322385426185 0.363981729108367 miRNATAP -0.199518724584192 0.00392315137047489 NA NA NA hsa-miR-125a-3p RPS6KA3 0.176962424592259 0.470664422494846 0.172322385426185 0.363981729108367 MirTarget;PITA;miRanda;miRNATAP -0.10120710222421 0.000787089789432113 NA NA NA hsa-miR-146b-3p RPS6KA3 -0.319493995064978 0.163980882060085 0.172322385426185 0.363981729108367 PITA;miRNATAP -0.191905867063606 2.08615645935529e-06 NA NA NA hsa-miR-181a-5p RPS6KA3 0.0500140102175894 0.858002548083348 0.172322385426185 0.363981729108367 MirTarget;mirMAP;miRNATAP -0.130560589538182 0.00470625225436748 NA NA NA hsa-miR-181b-5p RPS6KA3 0.114077927538188 0.649177797934569 0.172322385426185 0.363981729108367 MirTarget;mirMAP;miRNATAP -0.135367016219692 0.00255263774172863 NA NA NA hsa-miR-21-5p RPS6KA3 -0.0799831466796448 0.848619631369434 0.172322385426185 0.363981729108367 miRNAWalker2_validate;mirMAP;miRNATAP -0.143401299186282 0.0266217124842545 NA NA NA hsa-miR-330-5p RPS6KA3 -0.208237370447446 0.294261001891667 0.172322385426185 0.363981729108367 PITA;miRanda;miRNATAP -0.176751040863203 0.000369813323194387 NA NA NA hsa-miR-15b-5p RPS6KA6 0.101141961851801 0.680859173657598 1.26224692479417 0.0263183415826187 MirTarget -0.811160863135549 0.000449723382487955 NA NA NA hsa-miR-16-5p RPS6KA6 0.145487293472948 0.590284028672631 1.26224692479417 0.0263183415826187 MirTarget -0.643861771198276 0.00545292888494857 NA NA NA hsa-miR-26b-5p RPS6KA6 0.124364243009017 0.63657079673149 1.26224692479417 0.0263183415826187 miRNAWalker2_validate;MirTarget -0.658424655831347 0.0168046237933103 NA NA NA hsa-miR-590-3p RPS6KA6 0.61452706068502 0.00851921195946504 1.26224692479417 0.0263183415826187 MirTarget;miRanda;mirMAP;miRNATAP -0.459330490563038 0.00743580331786831 NA NA NA hsa-miR-181c-5p RPS6KB1 0.31948559060922 0.126696663734917 0.0850993908917577 0.524882653759531 MirTarget;miRNATAP -0.105699068327426 8.16023080416683e-05 NA NA NA hsa-miR-27b-3p RPS6KB1 -0.185080190423129 0.492088030771146 0.0850993908917577 0.524882653759531 MirTarget;miRNATAP -0.106197424161292 0.026159748983879 NA NA NA hsa-miR-30a-5p RPS6KB1 -0.045302777291603 0.880974166508925 0.0850993908917577 0.524882653759531 mirMAP;miRNATAP -0.128600939153832 0.00108269533119504 NA NA NA hsa-let-7a-3p RSPO2 0.101609552389411 0.646619196813319 -0.523989063641546 0.211485200821416 MirTarget -0.762635763692952 2.61820243660221e-06 NA NA NA hsa-let-7a-3p RSPO3 0.101609552389411 0.646619196813319 -0.48989311693143 0.211111794249111 MirTarget -0.800681607647926 1.42716840449831e-07 NA NA NA hsa-let-7a-3p RTN1 0.101609552389411 0.646619196813319 -0.36087286116786 0.275935267564428 miRNATAP -0.580766687237098 7.91131427942045e-06 NA NA NA hsa-let-7a-3p SAMD4A 0.101609552389411 0.646619196813319 -0.330925488435857 0.100126258514626 miRNATAP -0.37521463410034 4.30307179842972e-07 NA NA NA hsa-let-7a-3p SASH1 0.101609552389411 0.646619196813319 -0.453620797572915 0.00412158762988481 mirMAP -0.116088033522894 0.015872353904294 NA NA NA hsa-let-7a-3p SBNO1 0.101609552389411 0.646619196813319 -0.141232698465835 0.330946151364158 mirMAP;miRNATAP -0.147666412153496 0.000618876570716609 NA NA NA hsa-let-7a-3p SCARF1 0.101609552389411 0.646619196813319 -0.391569815352873 0.0178278882550597 MirTarget -0.279713097595108 9.84742805362985e-06 NA NA NA hsa-let-7a-3p SCN2A 0.101609552389411 0.646619196813319 -0.315741296043596 0.444682138003498 mirMAP;miRNATAP -0.500231659831465 0.00161336761313887 NA NA NA hsa-let-7a-3p SCN2B 0.101609552389411 0.646619196813319 -0.605556011441914 0.184806597210046 mirMAP -1.16908893514724 7.45018564788298e-12 NA NA NA hsa-let-7a-3p SCN3A 0.101609552389411 0.646619196813319 0.0499909918573918 0.887019071270192 mirMAP -0.605204530813437 8.94086897529347e-06 NA NA NA hsa-let-7a-3p SCN7A 0.101609552389411 0.646619196813319 -0.805390072688001 0.146417769328769 mirMAP -1.46177023488104 1.69731487701596e-12 NA NA NA hsa-let-7a-3p SCN9A 0.101609552389411 0.646619196813319 -0.774119849046608 0.0303864331401518 mirMAP -0.946034934685484 4.41979857022062e-12 NA NA NA hsa-let-7a-3p SDC2 0.101609552389411 0.646619196813319 -0.365184122317518 0.115670022418363 MirTarget -0.537387285704146 6.69136121653752e-12 NA NA NA hsa-let-7a-3p SDK1 0.101609552389411 0.646619196813319 -1.08677905528251 0.00141106093627149 mirMAP -0.340691420638116 0.0129061181996169 NA NA NA hsa-let-7a-3p SEC23A 0.101609552389411 0.646619196813319 0.0893941683672619 0.600385334730295 MirTarget;mirMAP;miRNATAP -0.129720891756095 0.00133879198263458 NA NA NA hsa-let-7a-3p SECISBP2L 0.101609552389411 0.646619196813319 -0.161470982392608 0.265219329147002 mirMAP -0.121305539658678 0.00183872046024442 NA NA NA hsa-let-7a-3p SELE 0.101609552389411 0.646619196813319 -0.224731492124032 0.547827449487326 MirTarget -0.802433056664213 4.27968481047355e-08 NA NA NA hsa-let-7a-3p SEMA3D 0.101609552389411 0.646619196813319 -0.736715125004849 0.0954317236980503 mirMAP -0.901939031032647 1.46931323314417e-07 NA NA NA hsa-let-7a-3p SENP7 0.101609552389411 0.646619196813319 0.112481868263183 0.360017455930356 miRNAWalker2_validate -0.122359693499163 0.00270844182567183 NA NA NA hsa-let-7a-3p SFRP2 0.101609552389411 0.646619196813319 -0.765588989890337 0.218902166752436 miRNATAP -1.19419982770431 8.44331763953112e-07 NA NA NA hsa-let-7a-3p SGIP1 0.101609552389411 0.646619196813319 -0.257108155832705 0.27271366415971 mirMAP -0.533562629541931 3.42331578137799e-09 NA NA NA hsa-let-7a-3p SGTB 0.101609552389411 0.646619196813319 -0.112104504725788 0.413042445394498 MirTarget;miRNATAP -0.179952674149317 0.000244799084844391 NA NA NA hsa-let-7a-3p SIX4 0.101609552389411 0.646619196813319 -0.540081005496813 0.0880665286122603 mirMAP -0.458038759009518 0.000269118586046217 NA NA NA hsa-let-7a-3p SKIL 0.101609552389411 0.646619196813319 0.289249546539627 0.119184180645933 mirMAP;miRNATAP -0.145226576258629 0.0208180680422029 NA NA NA hsa-let-7a-3p SLC18A2 0.101609552389411 0.646619196813319 -0.253662240400246 0.336151574449564 MirTarget;miRNATAP -0.397815079982185 8.02557362366609e-05 NA NA NA hsa-let-7a-3p SLC1A2 0.101609552389411 0.646619196813319 -0.349729619589463 0.219202910696059 miRNATAP -0.260528750461597 0.0173724424721969 NA NA NA hsa-let-7a-3p SLC6A17 0.101609552389411 0.646619196813319 -0.991740424266146 0.00207091708509519 miRNATAP -0.512332473733683 3.75891754937166e-05 NA NA NA hsa-let-7a-3p SLC7A2 0.101609552389411 0.646619196813319 -1.69565991601911 1.76461147208063e-06 MirTarget -0.465078079201533 0.00130142250465309 NA NA NA hsa-let-7a-3p SLITRK3 0.101609552389411 0.646619196813319 -0.646048950915006 0.174191258367063 miRNATAP -1.36003563551113 3.81062916330363e-15 NA NA NA hsa-let-7a-3p SMAD9 0.101609552389411 0.646619196813319 -0.895165397134496 0.015487267625782 mirMAP -0.316094009167273 0.0338943587613516 NA NA NA hsa-let-7a-3p SMO 0.101609552389411 0.646619196813319 -0.00549094329614652 0.984298793899408 MirTarget;miRNATAP -0.290079801348381 0.0068681168303185 NA NA NA hsa-let-7a-3p SNAI1 0.101609552389411 0.646619196813319 -0.0136637171995857 0.939937811735657 miRNATAP -0.240033025786024 0.000285142877263354 NA NA NA hsa-let-7a-3p SNCA 0.101609552389411 0.646619196813319 -1.32922474839944 6.09128410052158e-05 mirMAP -0.720385331302896 3.67042774595845e-08 NA NA NA hsa-let-7a-3p SNX10 0.101609552389411 0.646619196813319 0.0893914566534759 0.641585024864024 mirMAP -0.171449218400762 0.011327645539396 NA NA NA hsa-let-7a-3p SOAT1 0.101609552389411 0.646619196813319 -0.285873376368211 0.180477322443318 mirMAP -0.242494696468343 0.00127274817252281 NA NA NA hsa-let-7a-3p SORBS1 0.101609552389411 0.646619196813319 0.0307072298768833 0.912402770623845 miRNATAP -0.549759923997115 1.41757214894194e-08 NA NA NA hsa-let-7a-3p SOX11 0.101609552389411 0.646619196813319 -0.674898135621396 0.0320885324343876 miRNATAP -0.45397440057564 0.00029648452617381 NA NA NA hsa-let-7a-3p SOX5 0.101609552389411 0.646619196813319 -0.0725229066092661 0.810203101239272 mirMAP -0.603979215157227 1.58623925623023e-07 NA NA NA hsa-let-7a-3p SPAG9 0.101609552389411 0.646619196813319 0.216803482201313 0.222718357244182 mirMAP -0.105534351892329 0.00992592970433298 NA NA NA hsa-let-7a-3p SPATA13 0.101609552389411 0.646619196813319 0.399565394036859 0.0397805091725104 MirTarget -0.199544859185589 0.0052453142028302 NA NA NA hsa-let-7a-3p SPOCK1 0.101609552389411 0.646619196813319 -0.841170197563365 0.0525343277853061 mirMAP -0.969593863431252 6.30406465475896e-09 NA NA NA hsa-let-7a-3p ST6GAL2 0.101609552389411 0.646619196813319 0.401149993438883 0.430043324392108 miRNATAP -0.786309258799329 9.17029512306906e-05 NA NA NA hsa-let-7a-3p ST6GALNAC3 0.101609552389411 0.646619196813319 -0.0755557927966555 0.74860502323581 MirTarget -0.189762184851356 0.0438332840491062 NA NA NA hsa-let-7a-3p STOX2 0.101609552389411 0.646619196813319 -0.37397340399006 0.239553758643988 mirMAP -0.600813458487328 2.87391336549032e-07 NA NA NA hsa-let-7a-3p STRN 0.101609552389411 0.646619196813319 0.113368959027916 0.425400168364719 mirMAP -0.126098855208663 0.00584351725303666 NA NA NA hsa-let-7a-3p SV2B 0.101609552389411 0.646619196813319 -0.614274183808465 0.10527107872275 MirTarget;mirMAP -0.851499761862744 5.19032449474897e-09 NA NA NA hsa-let-7a-3p SWAP70 0.101609552389411 0.646619196813319 -0.333853749253932 0.0240764077282573 MirTarget -0.107913504269791 0.00502025658568432 NA NA NA hsa-let-7a-3p SYNGR1 0.101609552389411 0.646619196813319 -0.756914433659544 0.0132929399022594 miRNATAP -0.413981356621858 0.000741262075253495 NA NA NA hsa-let-7a-3p SYNJ1 0.101609552389411 0.646619196813319 -0.0503855283610348 0.679078957390028 mirMAP -0.103886225479171 0.006824677407815 NA NA NA hsa-let-7a-3p TACC1 0.101609552389411 0.646619196813319 -0.45118584632688 0.0438468724564795 MirTarget;mirMAP -0.161509215240318 0.0127804368541417 NA NA NA hsa-let-7a-3p TANC2 0.101609552389411 0.646619196813319 -0.73425674716755 0.00374312031521896 miRNATAP -0.316356949763268 0.00136839751467035 NA NA NA hsa-let-7a-3p TAOK1 0.101609552389411 0.646619196813319 0.0437193652925081 0.797640513798119 MirTarget;miRNATAP -0.289186206275419 5.69874760925919e-06 NA NA NA hsa-let-7a-3p TBC1D2B 0.101609552389411 0.646619196813319 -0.122489539139516 0.467719780609203 MirTarget -0.141556969391109 0.000677700801648851 NA NA NA hsa-let-7a-3p TBCEL 0.101609552389411 0.646619196813319 0.0413468357513516 0.800915721412533 mirMAP -0.262157472929308 1.13526525457887e-05 NA NA NA hsa-let-7a-3p TCF4 0.101609552389411 0.646619196813319 -0.504392263024168 0.0245362081510131 mirMAP;miRNATAP -0.485159264019734 1.23111192976066e-09 NA NA NA hsa-let-7a-3p TGFB2 0.101609552389411 0.646619196813319 -0.166255097659906 0.508825840433749 miRNATAP -0.509553196595548 1.6994890144512e-07 NA NA NA hsa-let-7a-3p TGFB3 0.101609552389411 0.646619196813319 -0.711704664766704 0.0253331701340187 MirTarget -0.683864247335398 2.32084912745715e-08 NA NA NA hsa-let-7a-3p THBS1 0.101609552389411 0.646619196813319 -0.260704299193492 0.366348081057966 mirMAP -0.41118832969956 1.17692621132587e-05 NA NA NA hsa-let-7a-3p THRB 0.101609552389411 0.646619196813319 0.434639196212682 0.283483780141635 MirTarget;miRNATAP -0.400415971983236 0.0123572935862353 NA NA NA hsa-let-7a-3p TIGD7 0.101609552389411 0.646619196813319 0.110075218879903 0.524740497865994 MirTarget -0.134676015029932 0.0457749902014921 NA NA NA hsa-let-7a-3p TIMP3 0.101609552389411 0.646619196813319 -0.283680514316952 0.366504399357236 mirMAP;miRNATAP -0.563983933485885 3.38295067591527e-08 NA NA NA hsa-let-7a-3p TMEM117 0.101609552389411 0.646619196813319 0.0458660946063172 0.746715546778494 MirTarget -0.100519492361723 0.0368637962813297 NA NA NA hsa-let-7a-3p TMEM132B 0.101609552389411 0.646619196813319 -0.597239414981721 0.0586276413545882 MirTarget;mirMAP -0.254945344153406 0.0409725279334021 NA NA NA hsa-let-7a-3p TMEM170B 0.101609552389411 0.646619196813319 -0.0469208505943701 0.843998720906007 mirMAP -0.250384584704787 0.00833089284383446 NA NA NA hsa-let-7a-3p TMEM55A 0.101609552389411 0.646619196813319 0.667238281947202 0.000649701988017484 mirMAP -0.264708609367674 0.000364895268581335 NA NA NA hsa-let-7a-3p TMEM67 0.101609552389411 0.646619196813319 0.357334198459424 0.0225610920029515 mirMAP -0.141331834638967 0.0153204522639449 NA NA NA hsa-let-7a-3p TMOD2 0.101609552389411 0.646619196813319 0.252885579279249 0.261718134909717 mirMAP -0.266207433424316 0.00207876822599063 NA NA NA hsa-let-7a-3p TMTC1 0.101609552389411 0.646619196813319 -0.56006626762215 0.0301377693829985 mirMAP -0.533559295310267 1.09388046356749e-07 NA NA NA hsa-let-7a-3p TNFSF4 0.101609552389411 0.646619196813319 -0.563091608123985 0.0309151967132287 mirMAP -0.6031567130705 1.98374132385316e-09 NA NA NA hsa-let-7a-3p TNS3 0.101609552389411 0.646619196813319 0.0611627491093234 0.757586798598257 MirTarget;miRNATAP -0.182528797969579 0.000133674800820745 NA NA NA hsa-let-7a-3p TP53INP1 0.101609552389411 0.646619196813319 -0.227490235135824 0.171701579562071 mirMAP -0.169031080495452 0.00302201494963528 NA NA NA hsa-let-7a-3p TPM1 0.101609552389411 0.646619196813319 -0.434255962616668 0.0641927101361525 miRNATAP -0.11201705669995 0.0425223987585866 NA NA NA hsa-let-7a-3p TRIM23 0.101609552389411 0.646619196813319 0.00781579047042102 0.945311411144535 mirMAP -0.118501029903296 0.000702279606183227 NA NA NA hsa-let-7a-3p TRIM6 0.101609552389411 0.646619196813319 -0.0749682907102462 0.743049168048087 MirTarget -0.411820384024677 4.39281463602545e-06 NA NA NA hsa-let-7a-3p TSHZ3 0.101609552389411 0.646619196813319 -0.627094917868234 0.0072567055655391 MirTarget;miRNATAP -0.526063836522617 4.16978571271738e-09 NA NA NA hsa-let-7a-3p TSLP 0.101609552389411 0.646619196813319 -0.578187670528533 0.0500713194946082 MirTarget -0.262798462419184 0.0222441996565428 NA NA NA hsa-let-7a-3p TSPAN2 0.101609552389411 0.646619196813319 -0.323858716448032 0.271664223720261 MirTarget;mirMAP -0.717468335534669 8.96447798532594e-11 NA NA NA hsa-let-7a-3p TTC30A 0.101609552389411 0.646619196813319 0.0236883228834794 0.887295736318307 MirTarget;mirMAP -0.147584979486919 0.0216971619930343 NA NA NA hsa-let-7a-3p TWIST1 0.101609552389411 0.646619196813319 -0.436701382637772 0.134465840643491 MirTarget;miRNATAP -0.391095138990491 0.000702044457713798 21352471 Knocking down IL-6 and Twist in HSCs significantly reduced let-7 and miR-181 expression and subsequently inhibited chemoresistance and cell invasion drug resistance liver cancer hsa-let-7a-3p TXLNG 0.101609552389411 0.646619196813319 0.471876954698196 0.00313588976719839 miRNATAP -0.165775727515694 0.00359007667292489 NA NA NA hsa-let-7a-3p UBE2Q2 0.101609552389411 0.646619196813319 -0.160080245388533 0.287396966222618 MirTarget -0.132437117047085 0.00357275548358816 NA NA NA hsa-let-7a-3p UHMK1 0.101609552389411 0.646619196813319 0.000695874325551404 0.996997200171511 MirTarget;mirMAP -0.220061554496429 0.00133827679658503 NA NA NA hsa-miR-17-5p ULK1 0.654454113630718 0.0320922529414325 -0.216855010717355 0.176761374867682 TargetScan;miRNATAP -0.10505296704403 0.000252592861382422 NA NA NA hsa-miR-20a-5p ULK1 0.575987288988369 0.0504195522708827 -0.216855010717355 0.176761374867682 miRNATAP -0.119241371835733 2.25463894753358e-05 NA NA NA hsa-let-7d-5p ULK2 0.180687618914645 0.407153023455971 -0.346185458119852 0.0669257599843554 MirTarget -0.272394837278321 0.00905032837187636 NA NA NA hsa-let-7f-1-3p ULK2 0.0232337533686442 0.882480601364687 -0.346185458119852 0.0669257599843554 MirTarget -0.225075524598732 0.02080912587492 NA NA NA hsa-let-7f-5p ULK2 0.298975996701252 0.358142291880245 -0.346185458119852 0.0669257599843554 MirTarget -0.206454704144807 0.0385215969324238 NA NA NA hsa-let-7g-5p ULK2 0.277737429324977 0.265837688072841 -0.346185458119852 0.0669257599843554 MirTarget -0.340071802366301 0.000714900104650657 NA NA NA hsa-miR-1266-5p ULK2 0.0149671662717612 0.957649617975798 -0.346185458119852 0.0669257599843554 MirTarget -0.137407693998952 0.00311552148006114 NA NA NA hsa-miR-130b-3p ULK2 0.426186909383556 0.0535253475456448 -0.346185458119852 0.0669257599843554 MirTarget -0.19651002103566 0.00293826317925917 NA NA NA hsa-miR-141-3p ULK2 0.375303508996668 0.23369759511523 -0.346185458119852 0.0669257599843554 MirTarget;TargetScan -0.180413821274483 0.00089546304968732 NA NA NA hsa-miR-186-5p ULK2 0.0414271542658895 0.855875332337529 -0.346185458119852 0.0669257599843554 MirTarget -0.364058463805975 4.5657364187977e-05 NA NA NA hsa-miR-200a-3p ULK2 0.0859962582412201 0.779813959770487 -0.346185458119852 0.0669257599843554 MirTarget -0.183209084940938 0.000524935886553644 NA NA NA hsa-miR-200b-3p ULK2 0.155726849405916 0.625900255789875 -0.346185458119852 0.0669257599843554 MirTarget;TargetScan -0.205983814862157 0.000974852636579237 NA NA NA hsa-miR-200c-3p ULK2 0.312679230647506 0.396034062318706 -0.346185458119852 0.0669257599843554 MirTarget -0.172589395502469 0.00750414552160509 NA NA NA hsa-miR-301a-3p ULK2 0.350506157574251 0.119327493804133 -0.346185458119852 0.0669257599843554 MirTarget -0.114363253620784 0.0413827460824872 NA NA NA hsa-miR-421 ULK2 0.483846282376657 0.0175641163246583 -0.346185458119852 0.0669257599843554 miRanda;mirMAP -0.171589042660235 0.00526794740276995 NA NA NA hsa-miR-429 ULK2 0.229346217598988 0.464802955959168 -0.346185458119852 0.0669257599843554 MirTarget;PITA;miRanda;miRNATAP -0.142791226816057 0.00491370237562058 NA NA NA hsa-miR-454-3p ULK2 0.493936490517753 0.00397224628288767 -0.346185458119852 0.0669257599843554 MirTarget -0.180334625112546 0.0191029137521148 NA NA NA hsa-miR-576-5p ULK2 -0.0646836612801551 0.749193541371544 -0.346185458119852 0.0669257599843554 mirMAP -0.221316730192355 0.000547764185054711 NA NA NA hsa-miR-577 ULK2 -0.131565620416609 0.724256245908512 -0.346185458119852 0.0669257599843554 MirTarget;PITA;miRNATAP -0.130163352172481 8.38954651935983e-05 NA NA NA hsa-miR-582-5p ULK2 -0.228254145294111 0.237411325958129 -0.346185458119852 0.0669257599843554 miRNATAP -0.161976520602095 0.0202317175719431 NA NA NA hsa-miR-590-3p ULK2 0.61452706068502 0.00851921195946504 -0.346185458119852 0.0669257599843554 mirMAP -0.173150023795783 0.00119456696049665 NA NA NA hsa-miR-7-1-3p ULK2 -0.0548495194389744 0.804425982450317 -0.346185458119852 0.0669257599843554 MirTarget;mirMAP -0.155988794392772 0.0131805917519539 NA NA NA hsa-let-7a-3p UNC5C 0.101609552389411 0.646619196813319 -0.314900216311029 0.355359385800892 MirTarget -0.577848896779087 1.14966666159459e-05 NA NA NA hsa-let-7a-3p USP12 0.101609552389411 0.646619196813319 0.296075956954441 0.0877333066494892 MirTarget;mirMAP;miRNATAP -0.191377132639697 0.0013327442535865 NA NA NA hsa-let-7a-3p UTRN 0.101609552389411 0.646619196813319 -0.200633863518032 0.313380544999758 mirMAP;miRNATAP -0.13255439345061 0.0382389294911218 NA NA NA hsa-let-7a-3p VCAM1 0.101609552389411 0.646619196813319 -0.581589245106624 0.0228487678586693 MirTarget -0.565513015032381 6.46540861917718e-09 NA NA NA hsa-let-7a-3p VCAN 0.101609552389411 0.646619196813319 -0.525012593355268 0.0868639383305266 MirTarget -0.66133735766405 6.15130939932976e-10 NA NA NA hsa-miR-1-3p VEGFA -0.172123943095182 0.609948092856277 0.28869407424182 0.216205511342876 MirTarget -0.116378239250321 6.72225230732928e-05 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-129-5p VEGFA 0.0615759188429279 0.828873218115354 0.28869407424182 0.216205511342876 miRanda -0.105916187808699 0.00205982654647779 NA NA NA hsa-miR-145-5p VEGFA -0.216093290978916 0.520765108486316 0.28869407424182 0.216205511342876 miRNAWalker2_validate;miRTarBase -0.104175207076633 0.0208584086032839 24781864;24966896;22472569 Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically metastasis;; thyroid cancer;bladder cancer;sarcoma hsa-miR-150-5p VEGFA 0.136242141255115 0.6808433920543 0.28869407424182 0.216205511342876 miRNAWalker2_validate;miRTarBase -0.105332454174453 0.00212185781504366 NA NA NA hsa-miR-195-5p VEGFA 0.151752953269865 0.486771415518022 0.28869407424182 0.216205511342876 miRNAWalker2_validate;miRTarBase;MirTarget -0.17069720152047 0.00113687245030063 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-29c-3p VEGFA 0.0197591608436092 0.946014399511523 0.28869407424182 0.216205511342876 miRNAWalker2_validate;MirTarget -0.106127581348752 0.0435930024323741 NA NA NA hsa-miR-342-3p VEGFA -0.0385072509156021 0.868451741180898 0.28869407424182 0.216205511342876 miRanda;miRNATAP -0.180071200249696 0.000461735316514135 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-497-5p VEGFA 0.0588593222857097 0.74974374041188 0.28869407424182 0.216205511342876 MirTarget -0.132299612451853 0.0345691660015173 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer hsa-miR-642a-5p VEGFB -0.211544989209442 0.47198318126413 0.108635186076791 0.513297960899353 MirTarget -0.110252259736901 4.41057201692337e-05 NA NA NA hsa-miR-128-3p VEGFC 0.0881018421156554 0.698935281700046 -0.450342203634744 0.0567703452318221 miRNAWalker2_validate;MirTarget -0.703841140515502 1.79431671849186e-11 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC 0.153726329181235 0.482682863515283 -0.450342203634744 0.0567703452318221 MirTarget -0.577975043513837 2.82952367749584e-15 NA NA NA hsa-miR-27a-3p VEGFC 0.0134054647308091 0.962166646551862 -0.450342203634744 0.0567703452318221 MirTarget -0.506585140692086 0.000168779320063404 NA NA NA hsa-miR-27b-3p VEGFC -0.185080190423129 0.492088030771146 -0.450342203634744 0.0567703452318221 MirTarget -0.353484303399941 0.0237751488321994 23593282 We identified vascular endothelial growth factor C VEGFC as a novel target gene of miR-27b and determined that miR-27b functioned as an inhibitor of tumor progression and angiogenesis through targeting VEGFC in CRC; In summary an anti-tumor role for miR-27b and its novel target VEGFC in vivo could lead to tumor necrosis and provide a rationale for developing miR-27b as a therapeutic agent progression colorectal cancer hsa-miR-374a-5p VEGFC 0.319715396296898 0.0770941358748204 -0.450342203634744 0.0567703452318221 MirTarget -0.563100644665433 2.34179983517396e-06 NA NA NA hsa-miR-374b-5p VEGFC 0.420828077578832 0.0368215896674663 -0.450342203634744 0.0567703452318221 MirTarget -0.605816787637354 1.34969594387806e-07 NA NA NA hsa-miR-590-3p VEGFC 0.61452706068502 0.00851921195946504 -0.450342203634744 0.0567703452318221 miRanda -0.48851698816486 3.73378001214407e-13 NA NA NA hsa-let-7a-3p VGLL3 0.101609552389411 0.646619196813319 -0.694697361027304 0.026315297920998 mirMAP -0.701491053872918 7.20353470099627e-09 NA NA NA hsa-let-7a-3p VPS13B 0.101609552389411 0.646619196813319 0.149082716346839 0.327383072143097 mirMAP -0.144493231992925 0.00131898873216244 NA NA NA hsa-let-7a-3p WASF3 0.101609552389411 0.646619196813319 0.249224703614594 0.528298780480492 miRNATAP -0.636332770829483 4.48877831221663e-05 NA NA NA hsa-let-7a-3p WDFY3 0.101609552389411 0.646619196813319 0.0136173708488192 0.918722240067148 mirMAP;miRNATAP -0.143439986169561 3.35597865117766e-05 NA NA NA hsa-let-7a-3p WDR44 0.101609552389411 0.646619196813319 -0.0872388677772982 0.518229063684826 mirMAP -0.102987187259596 0.0143440786006533 NA NA NA hsa-let-7a-3p WDR47 0.101609552389411 0.646619196813319 0.0151625135304356 0.897262991549263 mirMAP -0.140022638552815 3.96076742297845e-05 NA NA NA hsa-let-7a-3p WNT5A 0.101609552389411 0.646619196813319 -0.171890931960973 0.516689456799177 miRNATAP -0.232925679293252 0.0170186134518784 NA NA NA hsa-let-7a-3p WNT9A 0.101609552389411 0.646619196813319 -1.28154485242369 0.000101890057401842 mirMAP -0.60525455253825 2.36092027856041e-06 NA NA NA hsa-let-7a-3p WWC2 0.101609552389411 0.646619196813319 0.31507481185406 0.19978346068921 MirTarget;mirMAP -0.403741294087971 8.842283255666e-06 NA NA NA hsa-let-7a-3p WWC3 0.101609552389411 0.646619196813319 0.110344452928514 0.533702418065843 mirMAP;miRNATAP -0.131448511223817 0.0112558361401624 NA NA NA hsa-let-7a-3p YAP1 0.101609552389411 0.646619196813319 0.381133851840728 0.051274912998195 mirMAP -0.106604091569295 0.0140318250567238 NA NA NA hsa-let-7a-3p ZBTB33 0.101609552389411 0.646619196813319 0.265203887495969 0.0669045588319557 mirMAP -0.104867805390396 0.00476169534845874 NA NA NA hsa-let-7a-3p ZDHHC20 0.101609552389411 0.646619196813319 0.227291581421501 0.205728168769643 MirTarget -0.233972836014403 0.000283904456581389 NA NA NA hsa-let-7a-3p ZFHX4 0.101609552389411 0.646619196813319 -0.954771312261074 0.0178649717463083 MirTarget;mirMAP;miRNATAP -0.966204959970826 6.73087920040218e-10 NA NA NA hsa-let-7a-3p ZFP37 0.101609552389411 0.646619196813319 -0.262447239900276 0.295958723737069 MirTarget;mirMAP -0.215414685083716 0.0316846597320217 NA NA NA hsa-let-7a-3p ZFPM2 0.101609552389411 0.646619196813319 -0.541754608703053 0.0685238105408334 miRNATAP -0.774062071253718 1.03403848304052e-11 NA NA NA hsa-let-7a-3p ZMAT3 0.101609552389411 0.646619196813319 -0.301066106462844 0.0987342255011039 mirMAP -0.340319811934054 2.22466728931602e-06 NA NA NA hsa-let-7a-3p ZNF304 0.101609552389411 0.646619196813319 -0.370298427953893 0.198744189894071 miRNATAP -0.329490447415152 0.00413244775039895 NA NA NA hsa-let-7a-3p ZNF415 0.101609552389411 0.646619196813319 0.383813862630543 0.225898605463997 MirTarget -0.371890350126686 0.00320975913772423 NA NA NA hsa-let-7a-3p ZNF43 0.101609552389411 0.646619196813319 0.357360301593091 0.33353863971706 MirTarget -0.35304798470617 0.0172391610861445 NA NA NA hsa-let-7a-3p ZNF430 0.101609552389411 0.646619196813319 0.11623861669329 0.291220000994251 MirTarget -0.11490738772109 0.00277100172306204 NA NA NA hsa-let-7a-3p ZNF521 0.101609552389411 0.646619196813319 -0.604087697295191 0.0178588247105248 miRNATAP -0.626984515237434 1.6953693929401e-10 NA NA NA hsa-let-7a-3p ZNF532 0.101609552389411 0.646619196813319 -0.121377466278485 0.566762253201846 MirTarget;miRNATAP -0.410727464288442 4.20596503789465e-08 NA NA NA hsa-let-7a-3p ZNF569 0.101609552389411 0.646619196813319 0.0221457071122086 0.928106096153233 MirTarget -0.201769095645988 0.0393120848556083 NA NA NA hsa-let-7a-3p ZNF791 0.101609552389411 0.646619196813319 0.0436189220381982 0.697738896160021 mirMAP -0.112693099798969 0.00120677770149597 NA NA NA hsa-let-7a-3p ZNF831 0.101609552389411 0.646619196813319 -0.162928535968515 0.639200579672107 mirMAP -0.451126745423381 0.000990557107904353 NA NA NA hsa-let-7a-3p ZSCAN12 0.101609552389411 0.646619196813319 0.19759180932615 0.197504722430719 mirMAP -0.166693562077404 0.00588391664976962 NA NA NA