miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-15b-3p ABCA1 3.57530146629867 5.89922785773482e-11 0.717236918567415 0.28063880259552 mirMAP -0.191104943367231 0.00432976273390409 NA NA NA hsa-miR-106b-5p ABCD2 2.80565545918114 1.14547999022566e-09 -2.81589989489524 0.00416165631465957 MirTarget -0.499795928154311 2.35544677675131e-05 NA NA NA hsa-miR-21-3p ABI2 3.50297439576639 6.39946844099206e-10 -1.23358004664041 0.00252327576208982 MirTarget -0.200481354705054 3.49895633952212e-07 NA NA NA hsa-miR-15b-3p ABL1 3.57530146629867 5.89922785773482e-11 -1.71762983287229 3.75044691377874e-07 MirTarget -0.130238515032693 0.000154491957774896 NA NA NA hsa-miR-15b-5p ABL1 3.32329949959268 8.40210501034588e-13 -1.71762983287229 3.75044691377874e-07 mirMAP -0.106769937878675 0.0085448676446359 NA NA NA hsa-miR-21-3p ACAD11 3.50297439576639 6.39946844099206e-10 -0.474476305992578 0.21913443640258 MirTarget -0.138999005840577 0.000195727594182695 NA NA NA hsa-miR-15b-3p ACADSB 3.57530146629867 5.89922785773482e-11 -1.50805803458329 0.00313886147475052 mirMAP -0.180877322942802 0.000447447305240647 NA NA NA hsa-miR-21-5p ACAT1 2.65163477806992 6.72089787690756e-16 -1.93765606032844 1.0764624977844e-05 miRNAWalker2_validate -0.335070543176052 5.90799441362287e-06 NA NA NA hsa-miR-125a-3p ACPP -0.0748960586927341 0.920735897434087 3.93166127084245 2.84153649250779e-05 MirTarget;miRanda -0.321404729456584 6.22892945434158e-06 NA NA NA hsa-miR-125a-5p ACPP -1.32352790615388 0.00714301627309467 3.93166127084245 2.84153649250779e-05 MirTarget;miRanda -0.268910451776025 0.0145960816925571 NA NA NA hsa-miR-192-5p ACPP 1.77716187978541 0.113485496183047 3.93166127084245 2.84153649250779e-05 MirTarget -0.102377503375439 0.0328374704399829 NA NA NA hsa-miR-326 ACPP 1.76645822596029 0.0367310428720192 3.93166127084245 2.84153649250779e-05 miRanda -0.127980944545669 0.0464631730834512 NA NA NA hsa-miR-491-5p ACPP 0.569358547192776 0.313310594748302 3.93166127084245 2.84153649250779e-05 miRanda -0.307942547169418 0.00154329653380245 NA NA NA hsa-miR-21-5p ACVR2A 2.65163477806992 6.72089787690756e-16 -0.445065558149398 0.276091557573621 miRNATAP -0.240840909377618 0.000401712397836834 NA NA NA hsa-miR-106b-5p ADAM19 2.80565545918114 1.14547999022566e-09 0.443738030545642 0.526293989182709 mirMAP -0.179049522716889 0.0342260618570958 NA NA NA hsa-miR-106b-5p ADAM9 2.80565545918114 1.14547999022566e-09 0.333591881509617 0.495534681387376 miRNATAP -0.131663065288231 0.0256399022118461 NA NA NA hsa-miR-15b-3p ADAMTS19 3.57530146629867 5.89922785773482e-11 -8.35671926530133 2.96366069860883e-08 MirTarget -0.762956743095221 6.87245080817417e-07 NA NA NA hsa-miR-106b-3p ADAMTS2 2.57689304590494 1.04870442173494e-07 -2.48962795672701 0.0191012480843736 miRNAWalker2_validate -0.555378132688969 5.02649647735098e-06 NA NA NA hsa-miR-106b-5p ADAMTS5 2.80565545918114 1.14547999022566e-09 -6.22026337884656 3.49544969370274e-11 miRNATAP -0.559128405312459 1.35082066372141e-06 NA NA NA hsa-miR-15b-3p ADAMTS5 3.57530146629867 5.89922785773482e-11 -6.22026337884656 3.49544969370274e-11 mirMAP -0.535996949089783 2.51543611225881e-08 NA NA NA hsa-miR-15b-5p ADAMTS5 3.32329949959268 8.40210501034588e-13 -6.22026337884656 3.49544969370274e-11 miRNATAP -0.671584191764759 2.27310045728885e-09 NA NA NA hsa-miR-15b-5p ADAMTSL3 3.32329949959268 8.40210501034588e-13 -3.54330817661613 0.0114447463693068 MirTarget -0.365809181289829 0.0283789570617763 NA NA NA hsa-miR-21-3p ADCY1 3.50297439576639 6.39946844099206e-10 -1.33967537741524 0.204457679829343 mirMAP -0.202624697561382 0.0498162394331616 NA NA NA hsa-miR-21-5p ADCY2 2.65163477806992 6.72089787690756e-16 -5.73916016086503 0.000188747903845494 MirTarget -1.02171279225299 7.98854419692751e-05 NA NA NA hsa-miR-21-3p ADCY6 3.50297439576639 6.39946844099206e-10 -0.736555257409443 0.15175401399068 mirMAP -0.161685593666513 0.00120192396706737 NA NA NA hsa-miR-106b-5p ADRA2A 2.80565545918114 1.14547999022566e-09 -3.42157988785826 0.0051196246569677 miRNATAP -0.745750173747543 3.28956526324647e-07 NA NA NA hsa-miR-15b-3p AFF2 3.57530146629867 5.89922785773482e-11 -0.503672574806179 0.771346420041901 mirMAP -0.372146940072014 0.0336790875859279 NA NA NA hsa-miR-21-3p AFF2 3.50297439576639 6.39946844099206e-10 -0.503672574806179 0.771346420041901 mirMAP -0.424058955524868 0.0121503403796552 NA NA NA hsa-miR-15b-3p AFF4 3.57530146629867 5.89922785773482e-11 -0.53581012224616 0.124162533727919 mirMAP -0.10098737152481 0.00390565125136941 NA NA NA hsa-miR-21-3p AFF4 3.50297439576639 6.39946844099206e-10 -0.53581012224616 0.124162533727919 mirMAP -0.125060075008895 0.000204044095199518 NA NA NA hsa-miR-15b-5p AGAP3 3.32329949959268 8.40210501034588e-13 -0.596013750131776 0.12107567205593 miRNATAP -0.128698773895233 0.00451907904426458 NA NA NA hsa-miR-15b-5p AGPAT4 3.32329949959268 8.40210501034588e-13 -1.7798624427314 0.0317728844501966 mirMAP -0.276942553128506 0.00482836195765911 NA NA NA hsa-miR-15b-5p AHCYL2 3.32329949959268 8.40210501034588e-13 -0.370064970000627 0.488657892788232 miRNATAP -0.132113150700352 0.0367009582231549 NA NA NA hsa-miR-106b-5p AHNAK 2.80565545918114 1.14547999022566e-09 -1.18541721981777 0.0309063330103585 miRNATAP -0.284516877299965 1.50157067998703e-05 NA NA NA hsa-miR-15b-5p AHRR 3.32329949959268 8.40210501034588e-13 -0.319653234096945 0.659582851883348 mirMAP -0.285422403765045 0.000839821920218274 NA NA NA hsa-miR-338-3p AIM2 0.447551118940466 0.558485097370031 5.33435524733157 0.0032921024297411 miRanda -0.501343566982042 0.000199736577079223 NA NA NA hsa-miR-106b-5p AKAP11 2.80565545918114 1.14547999022566e-09 -0.605654396359352 0.125082559430791 miRNAWalker2_validate -0.19142240228267 4.91737714668185e-05 NA NA NA hsa-miR-15b-5p AKAP11 3.32329949959268 8.40210501034588e-13 -0.605654396359352 0.125082559430791 MirTarget;miRNATAP -0.101330657278261 0.0299852441332561 NA NA NA hsa-miR-21-3p AKAP11 3.50297439576639 6.39946844099206e-10 -0.605654396359352 0.125082559430791 MirTarget -0.146574222458001 0.00012321638190276 NA NA NA hsa-miR-106b-5p AKAP13 2.80565545918114 1.14547999022566e-09 -1.49457219687341 0.000229778886806 MirTarget;mirMAP;miRNATAP -0.240762130006474 7.22003810236577e-07 NA NA NA hsa-miR-99a-5p AKAP2 -2.72139054000803 0.00621971944534118 -3.13025207576624 0.0403736812707877 miRNAWalker2_validate -0.193858880738224 0.0255641333265642 NA NA NA hsa-miR-21-5p AKAP6 2.65163477806992 6.72089787690756e-16 -2.96959822380312 1.29532064958258e-05 MirTarget -0.472172328194112 3.99931275079028e-05 NA NA NA hsa-miR-21-5p AKIRIN1 2.65163477806992 6.72089787690756e-16 -0.181505123249059 0.572756838957471 miRNATAP -0.136290961968689 0.0111260160371301 NA NA NA hsa-miR-106b-5p AKT3 2.80565545918114 1.14547999022566e-09 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.411504731855899 9.49650030459631e-06 NA NA NA hsa-miR-15b-5p AKT3 3.32329949959268 8.40210501034588e-13 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.254367737995205 0.00570754876367863 NA NA NA hsa-miR-125a-3p ALOX12 -0.0748960586927341 0.920735897434087 3.49817026924289 0.0213608735001513 miRanda -0.373195914296779 0.00116712640742615 NA NA NA hsa-miR-21-5p ALX1 2.65163477806992 6.72089787690756e-16 -3.17119807849084 0.0709394661114246 MirTarget;miRNATAP -1.00859310288925 0.000609514262132287 NA NA NA hsa-miR-21-3p AMOT 3.50297439576639 6.39946844099206e-10 -1.93588757754572 0.207007298744567 mirMAP -0.741770646519656 5.00153946902612e-07 NA NA NA hsa-miR-15b-5p AMOTL1 3.32329949959268 8.40210501034588e-13 -0.989320362301362 0.1813968290719 MirTarget;miRNATAP -0.27555559869551 0.00161556348476903 NA NA NA hsa-miR-106b-5p ANK2 2.80565545918114 1.14547999022566e-09 -5.409622416688 8.7040592161347e-07 MirTarget;miRNATAP -0.768321483658996 6.39119015696721e-09 NA NA NA hsa-miR-15b-5p ANK2 3.32329949959268 8.40210501034588e-13 -5.409622416688 8.7040592161347e-07 MirTarget;miRNATAP -0.625850107350274 1.74889373074692e-06 NA NA NA hsa-miR-106b-5p ANKRD12 2.80565545918114 1.14547999022566e-09 -0.494549669751143 0.188916723766922 MirTarget -0.105364134549705 0.0200592056046037 NA NA NA hsa-miR-106b-5p ANKRD29 2.80565545918114 1.14547999022566e-09 -2.36461939298396 0.0410284929716217 MirTarget -0.354517405194506 0.0113817450255806 NA NA NA hsa-miR-21-5p ANKRD46 2.65163477806992 6.72089787690756e-16 -1.14754785450864 0.00252593843371676 miRNAWalker2_validate;miRTarBase -0.359105115987052 9.72004475953457e-09 21219636 Knockdown of miR-21 significantly increased the expression of ANKRD46 at both mRNA and protein levels; ANKRD46 is newly identified as a direct target of miR-21 in BC breast cancer hsa-miR-106b-5p ANKRD50 2.80565545918114 1.14547999022566e-09 -0.0192402002625904 0.97180725350251 MirTarget;miRNATAP -0.195770416976409 0.00276683767551445 NA NA NA hsa-miR-21-5p ANKS1B 2.65163477806992 6.72089787690756e-16 -3.56781235838185 0.00191207920687717 MirTarget -0.650734730554918 0.000778663840081058 NA NA NA hsa-miR-21-5p ANO3 2.65163477806992 6.72089787690756e-16 -3.39878260922822 0.00628309903736757 mirMAP -0.506894469153622 0.0158395162572448 NA NA NA hsa-miR-106b-5p ANO6 2.80565545918114 1.14547999022566e-09 -1.41782235968527 0.000168013749385316 MirTarget -0.223663857717057 7.1333645756832e-07 NA NA NA hsa-miR-21-5p ANP32A 2.65163477806992 6.72089787690756e-16 0.42276402143963 0.142316864909488 miRNAWalker2_validate;miRTarBase -0.127867735684038 0.00776693477553484 NA NA NA hsa-miR-15b-3p ANTXR1 3.57530146629867 5.89922785773482e-11 -1.71742669200421 0.0100758428785672 mirMAP -0.311975945429299 3.01074097205197e-06 NA NA NA hsa-miR-15b-3p ANTXR2 3.57530146629867 5.89922785773482e-11 -4.24605569649035 1.4390256739405e-07 mirMAP -0.379341080370012 3.9862255918122e-06 NA NA NA hsa-miR-99a-5p AP2B1 -2.72139054000803 0.00621971944534118 -0.737170779830582 0.270549467943456 miRNAWalker2_validate -0.159200102562515 2.18745762664764e-05 NA NA NA hsa-miR-106b-5p APBB2 2.80565545918114 1.14547999022566e-09 -1.53436038486834 0.00158116861980178 MirTarget;miRNATAP -0.116593529936087 0.0482973769934343 NA NA NA hsa-miR-15b-3p APBB2 3.57530146629867 5.89922785773482e-11 -1.53436038486834 0.00158116861980178 mirMAP -0.180068490869211 0.00023822370266305 NA NA NA hsa-miR-15b-5p APLNR 3.32329949959268 8.40210501034588e-13 -1.36690949949082 0.099276209777222 MirTarget -0.422364132277513 1.4177856610984e-05 NA NA NA hsa-miR-335-5p APOC1 0.167216045757305 0.803897055331049 3.7654680180798 0.000443871549029624 miRNAWalker2_validate -0.191303675212176 0.0366181612971941 NA NA NA hsa-miR-21-5p APOLD1 2.65163477806992 6.72089787690756e-16 -3.28520772685326 4.27808480350729e-09 miRNAWalker2_validate -0.517183346225153 4.48745456469601e-08 NA NA NA hsa-miR-21-5p APPL1 2.65163477806992 6.72089787690756e-16 -0.452504992110235 0.217297948897163 miRNAWalker2_validate -0.132652939017072 0.0308133551193579 NA NA NA hsa-miR-106b-5p AR 2.80565545918114 1.14547999022566e-09 -4.5730296286837 0.00169070552929284 mirMAP -0.671565961499113 0.000135491532342244 NA NA NA hsa-miR-15b-5p AR 3.32329949959268 8.40210501034588e-13 -4.5730296286837 0.00169070552929284 mirMAP;miRNATAP -0.34206396512017 0.0494349100652306 NA NA NA hsa-miR-106b-5p ARHGAP1 2.80565545918114 1.14547999022566e-09 -0.845390174623902 0.00368789153677755 MirTarget;miRNATAP -0.179960072198765 1.84199908002859e-07 NA NA NA hsa-miR-15b-5p ARHGAP20 3.32329949959268 8.40210501034588e-13 -3.55822292741935 0.00051193912705013 MirTarget;miRNATAP -0.538544336317588 8.58244797434735e-06 NA NA NA hsa-miR-106b-5p ARHGAP23 2.80565545918114 1.14547999022566e-09 0.120248559496768 0.890848785022467 mirMAP -0.351878277982004 0.000828975758622263 NA NA NA hsa-miR-21-5p ARHGAP24 2.65163477806992 6.72089787690756e-16 -1.63851222047594 0.0630105315781721 MirTarget;miRNATAP -0.453097613923613 0.00218776533002278 NA NA NA hsa-miR-15b-3p ARHGAP28 3.57530146629867 5.89922785773482e-11 -2.52434334336667 0.0426301253491 mirMAP -0.436406288573448 0.000506140064236228 NA NA NA hsa-miR-15b-3p ARHGAP32 3.57530146629867 5.89922785773482e-11 0.909001968974111 0.12571965608352 mirMAP -0.214341934704738 0.00032390351632488 NA NA NA hsa-miR-15b-5p ARHGAP32 3.32329949959268 8.40210501034588e-13 0.909001968974111 0.12571965608352 MirTarget -0.201449520812306 0.00409065303628001 NA NA NA hsa-miR-21-3p ARHGAP6 3.50297439576639 6.39946844099206e-10 -5.44836894935852 1.96802214068867e-09 MirTarget -0.627544984214892 9.49754036807947e-13 NA NA NA hsa-miR-15b-5p ARHGEF12 3.32329949959268 8.40210501034588e-13 -0.40418218327084 0.285378223068756 MirTarget -0.119589612132673 0.00730837996487847 NA NA NA hsa-miR-106b-5p ARHGEF3 2.80565545918114 1.14547999022566e-09 -0.999832613733417 0.015997285852657 MirTarget;miRNATAP -0.16080446862227 0.00129083768876118 NA NA NA hsa-miR-106b-5p ARID4A 2.80565545918114 1.14547999022566e-09 -0.654950580434493 0.0499700168114352 MirTarget;miRNATAP -0.119214455655161 0.0029676736042986 NA NA NA hsa-miR-21-5p ARL1 2.65163477806992 6.72089787690756e-16 -0.803379630726402 0.00238543463398299 MirTarget -0.20026904318721 4.78775946940456e-06 NA NA NA hsa-miR-21-3p ARL10 3.50297439576639 6.39946844099206e-10 -0.752217820421508 0.352817357063532 mirMAP -0.236020255313003 0.00274396449530553 NA NA NA hsa-miR-21-5p ARMCX1 2.65163477806992 6.72089787690756e-16 -4.07320855928524 1.43985485971249e-06 MirTarget -0.381170125860651 0.00829063898924687 NA NA NA hsa-miR-21-5p ARMCX3 2.65163477806992 6.72089787690756e-16 -1.48050394366406 0.0235560772786038 miRNAWalker2_validate -0.368788473868043 0.000767834132393674 NA NA NA hsa-miR-21-5p ASF1A 2.65163477806992 6.72089787690756e-16 -0.0686207257767792 0.84482835129483 miRNATAP -0.219770656842356 0.000157827247025005 NA NA NA hsa-miR-106b-5p ASH1L 2.80565545918114 1.14547999022566e-09 -0.250774489152632 0.532825909303775 miRNATAP -0.103140267454784 0.0331299038503055 NA NA NA hsa-miR-106b-5p ASPA 2.80565545918114 1.14547999022566e-09 -5.52741495660231 2.88694337207019e-06 mirMAP -0.573093711551851 6.85949267742521e-05 NA NA NA hsa-miR-15b-3p ASPA 3.57530146629867 5.89922785773482e-11 -5.52741495660231 2.88694337207019e-06 mirMAP -0.58058640226492 1.22434271425287e-06 NA NA NA hsa-miR-21-5p ASPN 2.65163477806992 6.72089787690756e-16 -5.36820252042446 1.0567203513391e-07 MirTarget;miRNATAP -0.572062377418058 0.0009229497671629 NA NA NA hsa-miR-21-5p ASRGL1 2.65163477806992 6.72089787690756e-16 -0.330217227955125 0.802764269690931 miRNAWalker2_validate -0.51627390460593 0.0200884285229284 NA NA NA hsa-miR-15b-5p ASTN1 3.32329949959268 8.40210501034588e-13 -4.82302728710604 0.000398573879439014 MirTarget -0.6611852051354 4.21673058417277e-05 NA NA NA hsa-miR-106b-5p ATP1A2 2.80565545918114 1.14547999022566e-09 -6.92354323482892 1.96163751729665e-07 MirTarget;miRNATAP -0.801518859349501 7.15799712743573e-07 NA NA NA hsa-miR-21-5p ATP2B2 2.65163477806992 6.72089787690756e-16 -4.37079959161119 0.00041576016493041 mirMAP -0.858446167869897 3.70875869966008e-05 NA NA NA hsa-miR-21-5p ATP2B4 2.65163477806992 6.72089787690756e-16 -2.12650684565315 4.77795984391287e-06 miRNAWalker2_validate;MirTarget -0.250932228102742 0.00147029148179852 NA NA NA hsa-miR-15b-3p ATP9A 3.57530146629867 5.89922785773482e-11 -0.0704292689139061 0.898617184962858 mirMAP -0.122740966213983 0.0277038842029161 NA NA NA hsa-miR-21-3p ATRNL1 3.50297439576639 6.39946844099206e-10 -7.15635153091464 2.50019094340527e-06 MirTarget -0.937262373002201 1.7304908814165e-10 NA NA NA hsa-miR-21-5p ATRNL1 2.65163477806992 6.72089787690756e-16 -7.15635153091464 2.50019094340527e-06 MirTarget -1.25251776972807 1.00235796828763e-06 NA NA NA hsa-miR-15b-3p ATXN1 3.57530146629867 5.89922785773482e-11 -1.43276235653597 0.00387135474046219 mirMAP;miRNATAP -0.178760604160081 0.000351815630270804 NA NA NA hsa-miR-21-5p ATXN10 2.65163477806992 6.72089787690756e-16 -0.369889814019477 0.198368213513303 MirTarget;miRNATAP -0.139117509625361 0.00365641010943163 NA NA NA hsa-miR-15b-5p AXIN2 3.32329949959268 8.40210501034588e-13 -3.82407466660445 0.000332783445696398 miRTarBase;MirTarget;miRNATAP -0.467609074192871 0.00022236000942262 NA NA NA hsa-miR-21-5p B3GALNT1 2.65163477806992 6.72089787690756e-16 -0.844368004694122 0.157767695209817 miRNAWalker2_validate -0.292689268189727 0.0034737314674683 NA NA NA hsa-miR-15b-5p BACE1 3.32329949959268 8.40210501034588e-13 -1.40969938009949 0.000937009517390126 miRNATAP -0.186757541904847 0.000210384198085171 NA NA NA hsa-miR-21-3p BACE1 3.50297439576639 6.39946844099206e-10 -1.40969938009949 0.000937009517390126 mirMAP -0.105765534946122 0.0113658893588697 NA NA NA hsa-miR-21-5p BACE1 2.65163477806992 6.72089787690756e-16 -1.40969938009949 0.000937009517390126 mirMAP -0.170147814306482 0.0180343619048923 NA NA NA hsa-miR-106b-5p BACH1 2.80565545918114 1.14547999022566e-09 0.100474433990045 0.823421129002714 mirMAP -0.173025040951335 0.00135256475696125 NA NA NA hsa-miR-21-5p BAHD1 2.65163477806992 6.72089787690756e-16 -0.556344462119145 0.0870104617337375 miRNATAP -0.124624353172273 0.0219849891578209 NA NA NA hsa-miR-106b-5p BCAS1 2.80565545918114 1.14547999022566e-09 -0.0665462408368804 0.968352588434047 mirMAP -0.484233849774454 0.016795872494484 NA NA NA hsa-miR-15b-3p BCL2 3.57530146629867 5.89922785773482e-11 -3.06316187948847 1.08810932834372e-05 mirMAP -0.160794111441143 0.0242966623676607 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-15b-5p BCL2 3.32329949959268 8.40210501034588e-13 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase -0.184030432349379 0.0279332632156109 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-21-5p BCL2 2.65163477806992 6.72089787690756e-16 -3.06316187948847 1.08810932834372e-05 miRNAWalker2_validate;miRTarBase -0.480047476048455 4.4710057406991e-05 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-106b-5p BCL9L 2.80565545918114 1.14547999022566e-09 -0.11736751068703 0.789850704970793 mirMAP -0.171823278679521 0.00113422986654843 NA NA NA hsa-miR-21-5p BDH2 2.65163477806992 6.72089787690756e-16 -1.21274631176534 0.00769611580892331 miRNAWalker2_validate -0.161323700353417 0.0354691070932709 NA NA NA hsa-miR-15b-5p BET1L 3.32329949959268 8.40210501034588e-13 -0.896015775722471 0.00126763248313296 mirMAP -0.115565963151072 0.000414215312576108 NA NA NA hsa-miR-15b-5p BEX1 3.32329949959268 8.40210501034588e-13 -6.13359198789608 8.39878327261028e-06 miRNAWalker2_validate -0.543958001974535 0.000975169404231853 NA NA NA hsa-miR-106b-5p BHLHE41 2.80565545918114 1.14547999022566e-09 -1.21562619538201 0.217286236514577 miRNATAP -0.446117729534556 0.000161124002830534 NA NA NA hsa-miR-106b-5p BICD2 2.80565545918114 1.14547999022566e-09 0.8634095483664 0.214130449097462 MirTarget;miRNATAP -0.180865466728205 0.0312920721137561 NA NA NA hsa-miR-106b-5p BMPR2 2.80565545918114 1.14547999022566e-09 -1.12630218798609 0.00109088044133536 MirTarget;miRNATAP -0.118630186532809 0.0044306068125726 NA NA NA hsa-miR-21-5p BMPR2 2.65163477806992 6.72089787690756e-16 -1.12630218798609 0.00109088044133536 miRNAWalker2_validate;miRTarBase;MirTarget -0.1214041231959 0.0368710131324604 NA NA NA hsa-miR-15b-5p BMX 3.32329949959268 8.40210501034588e-13 -5.34044049397677 5.09580291152701e-07 MirTarget;miRNATAP -0.663490192398655 1.45577619591889e-07 NA NA NA hsa-miR-106b-5p BNC2 2.80565545918114 1.14547999022566e-09 -6.04221863045668 1.28592064404143e-10 miRNATAP -0.690712531895418 1.54632320953104e-09 NA NA NA hsa-miR-21-5p BNC2 2.65163477806992 6.72089787690756e-16 -6.04221863045668 1.28592064404143e-10 miRNATAP -0.571896734422178 0.000422181300430188 NA NA NA hsa-miR-106b-5p BNIP3L 2.80565545918114 1.14547999022566e-09 -0.636917053318284 0.0991160631896998 MirTarget -0.104724660691971 0.0244745682702688 NA NA NA hsa-miR-21-5p BOC 2.65163477806992 6.72089787690756e-16 -4.15427169536598 6.11801575520565e-05 miRNAWalker2_validate -0.595131114847178 0.000693835536037531 NA NA NA hsa-miR-15b-5p BTBD19 3.32329949959268 8.40210501034588e-13 -2.25312121959319 0.0155696140733549 mirMAP -0.537404731730452 8.42673386897823e-07 NA NA NA hsa-miR-106b-5p BTG2 2.80565545918114 1.14547999022566e-09 -1.970617860216 0.000343824755617243 miRNATAP -0.189370973102998 0.00464250292035074 NA NA NA hsa-miR-21-5p BTG2 2.65163477806992 6.72089787690756e-16 -1.970617860216 0.000343824755617243 miRNAWalker2_validate;miRTarBase;miRNATAP -0.259058355886766 0.00538159078608719 24821435 miR 21 regulates N methyl N nitro N' nitrosoguanidine induced gastric tumorigenesis by targeting FASLG and BTG2 tumorigenesis gastric cancer hsa-miR-15b-5p BTLA 3.32329949959268 8.40210501034588e-13 1.19110977769682 0.197943467347687 MirTarget;miRNATAP -0.225050763983452 0.0403518164513143 NA NA NA hsa-miR-106b-5p BTN3A3 2.80565545918114 1.14547999022566e-09 -0.65713687541009 0.354595008499866 miRNAWalker2_validate -0.202930761587413 0.0178586195610313 NA NA NA hsa-miR-15b-5p BTRC 3.32329949959268 8.40210501034588e-13 -0.389242677076138 0.229517873289865 MirTarget;miRNATAP -0.14366136035681 0.000149866518688636 NA NA NA hsa-miR-21-5p C11orf87 2.65163477806992 6.72089787690756e-16 -3.96353102190994 0.00130676712385478 mirMAP;miRNATAP -0.567768861636513 0.00646617268880696 NA NA NA hsa-miR-106b-5p C14orf28 2.80565545918114 1.14547999022566e-09 -2.36193401895578 5.91654091584767e-10 miRNATAP -0.235402788323122 4.21890392353058e-07 NA NA NA hsa-miR-15b-5p C1orf21 3.32329949959268 8.40210501034588e-13 -1.27104982677537 0.0681023123830772 mirMAP;miRNATAP -0.174776429831953 0.0345912127511354 NA NA NA hsa-miR-21-3p C22orf29 3.50297439576639 6.39946844099206e-10 0.556720505083592 0.126434008958737 mirMAP -0.111948747016955 0.00152745226165565 NA NA NA hsa-miR-106b-5p C3orf70 2.80565545918114 1.14547999022566e-09 -3.41221136965833 0.000804520816457031 miRNATAP -0.440785088632286 0.00035011507965067 NA NA NA hsa-miR-15b-5p C8orf58 3.32329949959268 8.40210501034588e-13 -0.829179773695791 0.0487365218602553 miRNATAP -0.114264520011135 0.0217933003149487 NA NA NA hsa-miR-15b-3p CA10 3.57530146629867 5.89922785773482e-11 -3.41226452763699 0.0158891591019953 MirTarget -0.397521480642876 0.0055482657669109 NA NA NA hsa-miR-15b-3p CA5B 3.57530146629867 5.89922785773482e-11 -1.38414801199368 0.000929029456795403 mirMAP -0.106058597691034 0.0124102226840017 NA NA NA hsa-miR-21-3p CACNA2D1 3.50297439576639 6.39946844099206e-10 -0.900900006170782 0.611649328760661 mirMAP -0.512935329994974 0.00299340849141089 NA NA NA hsa-miR-15b-3p CACNB4 3.57530146629867 5.89922785773482e-11 -1.43375666922255 0.136472275667574 mirMAP -0.207788894040701 0.0330046481005996 NA NA NA hsa-miR-15b-5p CADM1 3.32329949959268 8.40210501034588e-13 -1.82364278704712 0.103960712759009 miRNATAP -0.303600587874528 0.0225588497412131 NA NA NA hsa-miR-15b-3p CALCRL 3.57530146629867 5.89922785773482e-11 -3.18347032888041 2.97483282122412e-05 mirMAP -0.383666009745548 5.89353194336925e-07 NA NA NA hsa-miR-106b-5p CALD1 2.80565545918114 1.14547999022566e-09 -3.83064204238261 3.35074002836634e-08 miRNATAP -0.43314724360883 2.78744089324615e-07 NA NA NA hsa-miR-15b-3p CALN1 3.57530146629867 5.89922785773482e-11 -3.00171454319827 0.0449657208616314 mirMAP -0.617573332787302 3.98214221608945e-05 NA NA NA hsa-miR-15b-5p CALN1 3.32329949959268 8.40210501034588e-13 -3.00171454319827 0.0449657208616314 mirMAP -0.55371851558639 0.00178586815681531 NA NA NA hsa-miR-15b-3p CAMK2A 3.57530146629867 5.89922785773482e-11 -4.61067365401457 0.000101073851621997 mirMAP -0.371629816235669 0.00210186189548789 NA NA NA hsa-miR-106b-5p CAMK2N1 2.80565545918114 1.14547999022566e-09 -1.93514940503735 0.0769687819444482 miRNATAP -0.320132616855363 0.0155992743080159 NA NA NA hsa-miR-106b-5p CAMK4 2.80565545918114 1.14547999022566e-09 0.834829388674018 0.395195460931575 mirMAP -0.247980869199913 0.0366839706311348 NA NA NA hsa-miR-21-3p CAMLG 3.50297439576639 6.39946844099206e-10 -1.58349686790634 1.11319247189323e-07 MirTarget -0.106548683487602 0.000289658757900497 NA NA NA hsa-miR-106b-5p CAPN5 2.80565545918114 1.14547999022566e-09 -1.42390963014371 0.218911913701285 mirMAP -0.315254199875953 0.0243777926807155 NA NA NA hsa-miR-15b-5p CAPN6 3.32329949959268 8.40210501034588e-13 -6.18399478133357 0.000960362440551915 miRNATAP -0.703504372041634 0.00160454408268363 NA NA NA hsa-miR-106b-5p CASC4 2.80565545918114 1.14547999022566e-09 -1.30997097375232 0.00161255968789974 MirTarget -0.133594834475254 0.00792716192170263 NA NA NA hsa-miR-21-5p CASKIN1 2.65163477806992 6.72089787690756e-16 1.61205000814141 0.147106695973811 MirTarget -0.524428388342491 0.00496497205035891 NA NA NA hsa-miR-106b-5p CAV1 2.80565545918114 1.14547999022566e-09 -3.37757611205378 0.000405196149106821 miRNATAP -0.341129943778492 0.00331225826235222 NA NA NA hsa-miR-106b-5p CAV2 2.80565545918114 1.14547999022566e-09 -1.1352921921114 0.158686571017278 mirMAP -0.216502420285715 0.0262067575993425 NA NA NA hsa-miR-15b-5p CBFA2T3 3.32329949959268 8.40210501034588e-13 -1.35603549043826 0.146662983337151 MirTarget;miRNATAP -0.340867160639655 0.00202119385090004 NA NA NA hsa-miR-21-3p CBL 3.50297439576639 6.39946844099206e-10 -0.223305458230699 0.601450588204973 MirTarget;mirMAP -0.106651772538801 0.0102848077123688 NA NA NA hsa-miR-106b-5p CBX7 2.80565545918114 1.14547999022566e-09 -3.22279320931286 6.52150812440456e-10 mirMAP -0.254473010338677 7.54628206444108e-05 NA NA NA hsa-miR-106b-5p CCBE1 2.80565545918114 1.14547999022566e-09 -5.42213590917212 0.00228388763323804 mirMAP -0.44617743657552 0.0392996322508551 NA NA NA hsa-miR-21-5p CCDC121 2.65163477806992 6.72089787690756e-16 -1.29167645307986 0.0030740904256628 MirTarget -0.27350248626708 0.000181707205586379 NA NA NA hsa-miR-15b-3p CCDC144A 3.57530146629867 5.89922785773482e-11 -0.258530881680983 0.84040370669383 mirMAP -0.30955911094324 0.0169466683472752 NA NA NA hsa-miR-140-5p CCNB1 -0.634610285725923 0.126670572966239 4.13671888610199 6.20633087555822e-26 miRanda -0.133985457001611 0.0233252324590732 NA NA NA hsa-miR-15b-5p CCND1 3.32329949959268 8.40210501034588e-13 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.423468924188888 0.000292921876666624 NA NA NA hsa-miR-106b-5p CCND2 2.80565545918114 1.14547999022566e-09 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309595760343179 0.00374413339981401 NA NA NA hsa-miR-15b-5p CCND2 3.32329949959268 8.40210501034588e-13 -2.81051675901102 0.00139983736368543 miRNATAP -0.527059068245043 3.31921597840683e-07 NA NA NA hsa-miR-125b-5p CCNE1 -2.01187572101832 0.00516480893645494 3.90668327437123 7.68546937179809e-18 miRNAWalker2_validate -0.127872185036842 0.000654725383789322 NA NA NA hsa-miR-195-5p CCNE1 -1.59182537400701 0.0169128463756769 3.90668327437123 7.68546937179809e-18 miRNAWalker2_validate;MirTarget;miRNATAP -0.11514367249823 0.00470453662143774 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-26a-5p CCNE1 -0.352368463397074 0.362040749917446 3.90668327437123 7.68546937179809e-18 miRNAWalker2_validate;miRTarBase;miRNATAP -0.184731728950396 0.00988349874140469 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-497-5p CCNE1 -1.44150596209372 0.0225146607606395 3.90668327437123 7.68546937179809e-18 MirTarget;miRNATAP -0.126936185159413 0.00315358484504579 24909281;24112607;25909221 miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1;Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells ;; cervical and endocervical cancer;breast cancer;lung cancer hsa-miR-21-5p CCNG1 2.65163477806992 6.72089787690756e-16 -1.09796577928737 0.00345685886529286 miRNAWalker2_validate -0.224886774894537 0.000346214932289102 NA NA NA hsa-miR-106b-5p CCNG2 2.80565545918114 1.14547999022566e-09 -0.753666435696529 0.104711088978229 MirTarget;miRNATAP -0.13630738060934 0.0149851764247418 NA NA NA hsa-miR-15b-3p CCPG1 3.57530146629867 5.89922785773482e-11 -1.11705712304016 0.0134690968002736 mirMAP -0.116149986015807 0.011051487582763 NA NA NA hsa-miR-106b-5p CD28 2.80565545918114 1.14547999022566e-09 0.133807523923012 0.875604699380063 mirMAP -0.209314015897388 0.0426678909246157 NA NA NA hsa-miR-15b-5p CD28 3.32329949959268 8.40210501034588e-13 0.133807523923012 0.875604699380063 MirTarget;miRNATAP -0.319411925705163 0.0015293420976101 NA NA NA hsa-miR-106b-5p CD34 2.80565545918114 1.14547999022566e-09 -4.41917607739575 1.17979202728271e-13 miRNAWalker2_validate -0.360665518340368 1.07343770390538e-06 NA NA NA hsa-miR-15b-5p CD3E 3.32329949959268 8.40210501034588e-13 0.77240848195285 0.414722946133718 MirTarget -0.237373755599671 0.0344654404866693 NA NA NA hsa-miR-15b-5p CD44 3.32329949959268 8.40210501034588e-13 -0.250888546168612 0.702623967117811 miRNAWalker2_validate -0.220420909314822 0.00448920132657962 NA NA NA hsa-miR-106b-5p CD69 2.80565545918114 1.14547999022566e-09 -0.719847271902471 0.423325336770428 miRNATAP -0.408184515969657 0.000152408804964689 NA NA NA hsa-miR-15b-5p CD80 3.32329949959268 8.40210501034588e-13 1.85820500486921 0.0387588872001837 MirTarget -0.212675070259197 0.0466936690347407 NA NA NA hsa-miR-15b-3p CD84 3.57530146629867 5.89922785773482e-11 1.30558461538378 0.171851999463804 mirMAP -0.211380152025956 0.0287811399383915 NA NA NA hsa-miR-15b-3p CD93 3.57530146629867 5.89922785773482e-11 -3.21977413354098 2.23102798779067e-08 mirMAP -0.412934863263026 6.01188534096274e-13 NA NA NA hsa-miR-15b-3p CDH6 3.57530146629867 5.89922785773482e-11 -2.03558837194243 0.0725884242894861 mirMAP -0.32776820462623 0.00421433209512584 NA NA NA hsa-miR-15b-3p CDH8 3.57530146629867 5.89922785773482e-11 -0.869054860916838 0.510921112786887 mirMAP -0.302358836393288 0.0236233846363056 NA NA NA hsa-miR-106b-5p CDKN1A 2.80565545918114 1.14547999022566e-09 0.575565460455045 0.357582494899873 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.166877448389873 0.0271337540807788 NA NA NA hsa-miR-10b-5p CDKN2A -3.08172917642729 4.22675074435126e-09 7.38430007921313 1.9263072669935e-15 miRNAWalker2_validate;miRTarBase -0.3561025709733 0.00054319451875627 NA NA NA hsa-miR-125a-5p CDKN2A -1.32352790615388 0.00714301627309467 7.38430007921313 1.9263072669935e-15 miRanda -0.392381455588874 0.000480466623544498 NA NA NA hsa-miR-192-5p CDKN2A 1.77716187978541 0.113485496183047 7.38430007921313 1.9263072669935e-15 miRNAWalker2_validate -0.113946193118328 0.0205094202279951 NA NA NA hsa-miR-15b-5p CECR6 3.32329949959268 8.40210501034588e-13 -0.0854648054596273 0.898236796266066 MirTarget;miRNATAP -0.341304128713363 1.26763372715627e-05 NA NA NA hsa-miR-106b-5p CELF2 2.80565545918114 1.14547999022566e-09 -2.48163199573256 0.00126436670635573 miRNATAP -0.317339937818385 0.000660916491215456 NA NA NA hsa-miR-497-5p CEP55 -1.44150596209372 0.0225146607606395 6.53512905731735 2.41145816341579e-39 MirTarget -0.106348174517571 0.0370997172540557 NA NA NA hsa-miR-21-5p CEP68 2.65163477806992 6.72089787690756e-16 -1.77239510025922 6.85934034025852e-06 miRNATAP -0.259905986198645 9.24032220744375e-05 NA NA NA hsa-miR-106b-5p CES2 2.80565545918114 1.14547999022566e-09 0.442789731925628 0.447464476010293 miRNAWalker2_validate -0.221956865787622 0.00152871044854051 NA NA NA hsa-miR-15b-5p CFLAR 3.32329949959268 8.40210501034588e-13 0.10975680494869 0.785876903093292 mirMAP -0.103078703550023 0.0306697621570958 NA NA NA hsa-miR-15b-3p CFTR 3.57530146629867 5.89922785773482e-11 -1.51472084062787 0.477499972217344 mirMAP -0.504460840568581 0.019242347182204 NA NA NA hsa-miR-338-3p CHAF1A 0.447551118940466 0.558485097370031 2.7534125231313 2.22831983273606e-14 MirTarget;PITA;miRanda -0.110085613167583 6.98837459163252e-05 NA NA NA hsa-miR-21-3p CHD5 3.50297439576639 6.39946844099206e-10 -1.82064803467001 0.0717005310307627 mirMAP -0.20051675480662 0.0428604943278877 NA NA NA hsa-miR-106b-5p CHD9 2.80565545918114 1.14547999022566e-09 -0.30348060334992 0.47580418564213 MirTarget;miRNATAP -0.209991261843462 3.50897477207655e-05 NA NA NA hsa-miR-15b-3p CHD9 3.57530146629867 5.89922785773482e-11 -0.30348060334992 0.47580418564213 mirMAP -0.124179058213776 0.00367661954819268 NA NA NA hsa-miR-15b-5p CHD9 3.32329949959268 8.40210501034588e-13 -0.30348060334992 0.47580418564213 miRNATAP -0.109459094882982 0.0294713759615551 NA NA NA hsa-miR-15b-3p CHL1 3.57530146629867 5.89922785773482e-11 -0.692031507301692 0.732451044252998 MirTarget -0.578499771148309 0.0045884334125459 NA NA NA hsa-miR-21-3p CHL1 3.50297439576639 6.39946844099206e-10 -0.692031507301692 0.732451044252998 MirTarget -0.518696768079715 0.00860609385428345 NA NA NA hsa-miR-15b-3p CHRDL1 3.57530146629867 5.89922785773482e-11 -10.0047369671436 6.00614874866061e-09 mirMAP -1.19963324235022 3.52131950435296e-12 NA NA NA hsa-miR-125a-5p CKS1B -1.32352790615388 0.00714301627309467 2.11452565802279 1.03678261710844e-06 miRanda -0.174645146533404 0.000560115707961357 NA NA NA hsa-miR-542-3p CKS1B -0.376147863244659 0.438002751207043 2.11452565802279 1.03678261710844e-06 miRNATAP -0.147145341732721 0.00451069076304568 NA NA NA hsa-miR-15b-3p CLCN5 3.57530146629867 5.89922785773482e-11 -0.133221746909874 0.774832731131052 mirMAP -0.158174989801305 0.000702614525816162 NA NA NA hsa-miR-15b-5p CLCN5 3.32329949959268 8.40210501034588e-13 -0.133221746909874 0.774832731131052 miRNATAP -0.126677164846633 0.0212809842551647 NA NA NA hsa-miR-21-5p CLCN5 2.65163477806992 6.72089787690756e-16 -0.133221746909874 0.774832731131052 miRNAWalker2_validate;mirMAP -0.217506566506633 0.0052139172501231 NA NA NA hsa-miR-106b-5p CLDN16 2.80565545918114 1.14547999022566e-09 1.65821137260309 0.223595040038291 mirMAP -0.388679431724173 0.0182795088657543 NA NA NA hsa-miR-106b-5p CLIP4 2.80565545918114 1.14547999022566e-09 -0.832090029193445 0.293856213352894 MirTarget -0.266090468794336 0.0053566439597751 NA NA NA hsa-miR-15b-5p CNN1 3.32329949959268 8.40210501034588e-13 -9.05682921992195 6.20108682054346e-14 miRNATAP -0.951119054671985 5.46786451384341e-11 NA NA NA hsa-miR-15b-3p CNR1 3.57530146629867 5.89922785773482e-11 -3.84631174825019 0.00528070039898352 mirMAP -0.533977020112193 0.000123639645057616 NA NA NA hsa-miR-21-3p CNRIP1 3.50297439576639 6.39946844099206e-10 -4.74028224016036 2.69588763185347e-12 MirTarget -0.378612442482588 1.84812309802204e-08 NA NA NA hsa-miR-21-5p CNTFR 2.65163477806992 6.72089787690756e-16 -4.16050425920299 0.0242985747340731 miRNATAP -0.947196646804256 0.00229340920061741 NA NA NA hsa-miR-15b-5p CNTNAP1 3.32329949959268 8.40210501034588e-13 -2.74731383124394 4.46013426861581e-06 MirTarget -0.265343203741068 0.000207330046375049 NA NA NA hsa-miR-106b-5p CNTNAP3 2.80565545918114 1.14547999022566e-09 0.849871958613229 0.50149474795117 MirTarget -0.360881789566559 0.0181156179677663 NA NA NA hsa-miR-15b-5p COL12A1 3.32329949959268 8.40210501034588e-13 -2.1321432334 0.0346678550324686 MirTarget;miRNATAP -0.439085867699426 0.000228501077516514 NA NA NA hsa-miR-106b-5p COL1A1 2.80565545918114 1.14547999022566e-09 -1.84056354039351 0.0428283936196076 mirMAP -0.527805230776855 1.12907897624131e-06 NA NA NA hsa-miR-15b-5p COL24A1 3.32329949959268 8.40210501034588e-13 -0.499426903459549 0.576571254067978 MirTarget;miRNATAP -0.280391424041697 0.0080176208839155 NA NA NA hsa-miR-99a-5p COL4A1 -2.72139054000803 0.00621971944534118 -1.16864065099484 0.0984791802100705 miRNAWalker2_validate -0.160770833475788 5.25644974578457e-05 NA NA NA hsa-miR-106b-5p COL8A2 2.80565545918114 1.14547999022566e-09 -0.623983269806004 0.47257399462785 mirMAP -0.492298559900783 1.93801118380353e-06 NA NA NA hsa-miR-106b-5p CORO2B 2.80565545918114 1.14547999022566e-09 -3.88545511875803 0.000597353268373863 MirTarget;miRNATAP -0.517233781903589 0.000159223774108801 NA NA NA hsa-miR-15b-5p CPEB2 3.32329949959268 8.40210501034588e-13 -0.479951556707431 0.400223167504707 miRNATAP -0.254966796455561 0.000141297038373848 NA NA NA hsa-miR-106b-5p CPEB3 2.80565545918114 1.14547999022566e-09 -0.0797174742695987 0.877984240376686 miRNATAP -0.239642631873073 0.000113386921330003 NA NA NA hsa-miR-106b-5p CPEB4 2.80565545918114 1.14547999022566e-09 -0.652644997143594 0.239456702650668 mirMAP -0.288113895057141 1.35346711032713e-05 NA NA NA hsa-miR-15b-3p CPEB4 3.57530146629867 5.89922785773482e-11 -0.652644997143594 0.239456702650668 mirMAP -0.230211873526439 3.3131435587141e-05 NA NA NA hsa-miR-21-3p CPEB4 3.50297439576639 6.39946844099206e-10 -0.652644997143594 0.239456702650668 mirMAP -0.171951645056418 0.00142454464523084 NA NA NA hsa-miR-21-3p CPLX2 3.50297439576639 6.39946844099206e-10 1.70036746584175 0.269069089149135 mirMAP -0.344748076886265 0.0218630462444937 NA NA NA hsa-miR-21-3p CREBBP 3.50297439576639 6.39946844099206e-10 -0.3958302023172 0.180670093990074 MirTarget -0.1378273582574 1.08112070034993e-06 NA NA NA hsa-miR-21-3p CREBL2 3.50297439576639 6.39946844099206e-10 -1.15991367576761 8.57382303345966e-05 MirTarget -0.114005367022938 7.24943209068847e-05 NA NA NA hsa-miR-335-5p CRNN 0.167216045757305 0.803897055331049 3.51221704540483 0.219202711912428 miRNAWalker2_validate -1.43671901618552 1.10171229818971e-09 NA NA NA hsa-miR-15b-3p CROT 3.57530146629867 5.89922785773482e-11 0.547630238170151 0.345245661034959 MirTarget -0.15324382562703 0.00877945160849512 NA NA NA hsa-miR-106b-5p CRY2 2.80565545918114 1.14547999022566e-09 -2.48917667476135 3.42360307446933e-15 MirTarget;miRNATAP -0.173696648901339 1.04973963818865e-05 NA NA NA hsa-miR-106b-5p CRYBG3 2.80565545918114 1.14547999022566e-09 -0.146038201579749 0.827129531499094 MirTarget;miRNATAP -0.219216165972824 0.00648286208157718 NA NA NA hsa-miR-106b-5p CSF1 2.80565545918114 1.14547999022566e-09 -1.10144752456835 0.127316209883384 miRNATAP -0.25632446917411 0.00324390838466919 NA NA NA hsa-miR-15b-3p CSF2RB 3.57530146629867 5.89922785773482e-11 -0.531949678174437 0.52469724338113 mirMAP -0.243883163153962 0.00378871588753218 NA NA NA hsa-miR-106b-5p CSGALNACT1 2.80565545918114 1.14547999022566e-09 -1.67737689179315 0.0188631392454775 MirTarget -0.235337059342354 0.00646268228592333 NA NA NA hsa-miR-15b-5p CSRNP1 3.32329949959268 8.40210501034588e-13 -2.14104200368726 6.4034573236666e-05 MirTarget -0.171289887683105 0.00747443335076853 NA NA NA hsa-miR-106b-5p CTSK 2.80565545918114 1.14547999022566e-09 -3.31545855742212 1.17171241137898e-05 MirTarget -0.743215271252758 2.86400609817561e-17 NA NA NA hsa-miR-15b-3p CTTNBP2NL 3.57530146629867 5.89922785773482e-11 -0.106954366909613 0.76728583877006 mirMAP -0.10480771320201 0.00382830898104944 NA NA NA hsa-miR-15b-5p CX3CL1 3.32329949959268 8.40210501034588e-13 -1.10050847999087 0.320313046819658 miRNATAP -0.294012387981604 0.025099097375425 NA NA NA hsa-miR-15b-5p CXCR5 3.32329949959268 8.40210501034588e-13 0.327068054119766 0.756575512146448 MirTarget -0.289854249365792 0.0203402101040499 NA NA NA hsa-miR-106b-5p CXorf36 2.80565545918114 1.14547999022566e-09 -4.77217277501607 1.39075625665653e-14 mirMAP -0.495975026143317 7.07180108912798e-11 NA NA NA hsa-miR-106b-5p CYBRD1 2.80565545918114 1.14547999022566e-09 -3.32547276652781 1.75725006888488e-06 MirTarget -0.312762296349595 0.00023071889213984 NA NA NA hsa-miR-99a-5p CYP26B1 -2.72139054000803 0.00621971944534118 1.58563908330085 0.0886003975315947 miRNATAP -0.209014420731699 6.63366228438421e-05 NA NA NA hsa-miR-125a-3p CYP2C9 -0.0748960586927341 0.920735897434087 2.39324654560898 0.173409179209142 miRanda -0.273113403968016 0.0404361948389426 NA NA NA hsa-miR-128-3p CYP2C9 1.36248409467631 0.00408435995818078 2.39324654560898 0.173409179209142 MirTarget -0.43676907073764 0.0388732158485658 25704921 To investigate the molecular mechanisms that control CYP2C9 expression we applied integrative approaches including in silico in vitro and in vivo analyses to elucidate the role of microRNA hsa-miR-128-3p in the regulation of CYP2C9 expression and translation; RNA electrophoresis mobility shift assays demonstrated a direct interaction between hsa-miR-128-3p and its cognate target the CYP2C9 transcript; Furthermore the expression of a luciferase reporter gene containing the 3'-UTR of CYP2C9 and the endogenous expression of CYP2C9 were suppressed by transfection of hsa-miR-128-3p; Importantly chemically-induced up- or down-regulation of hsa-miR-128-3p correlated inversely with the expression of CYP2C9; Finally an association analysis revealed that the expression of hsa-miR-128-3p is inversely correlated with the expression of CYP2C9 in HCC tumor tissues; Altogether the study helped to elucidate the mechanism of CYP2C9 regulation by hsa-miR-128-3p and the inverse association in HCC liver cancer hsa-miR-106b-5p CYP2U1 2.80565545918114 1.14547999022566e-09 -2.33323445176013 8.09845264949275e-05 MirTarget -0.181715282144817 0.0118607167361987 NA NA NA hsa-miR-21-5p CYP4V2 2.65163477806992 6.72089787690756e-16 -1.38047164409651 0.0225526653420036 miRNAWalker2_validate -0.222767454259536 0.0289486070705504 NA NA NA hsa-miR-15b-5p CYS1 3.32329949959268 8.40210501034588e-13 -4.70605605004161 1.01868609989663e-06 mirMAP -0.526959158081 4.36516545808851e-06 NA NA NA hsa-miR-106b-5p DAB2 2.80565545918114 1.14547999022566e-09 -2.2782007670164 0.000510161807747919 MirTarget;miRNATAP -0.373245322528672 2.13496676489413e-06 26769181 The expression of the miR-106b target gene DAB2 in human cervical tissues and cell lines were measured by qRT-PCR western blot and immunohistochemistry; DAB2 a predicted target gene of miR-106b was inhibited by TGF-β1 partly through miR-106b and was involved in TGF-β1-induced cervical cancer cell migration; The expression of DAB2 was low in cervical cancer tissues and negatively correlated with miR-106b expression cell migration cervical and endocervical cancer hsa-miR-15b-5p DAB2IP 3.32329949959268 8.40210501034588e-13 -0.670364609002058 0.147984370136276 mirMAP -0.195682870240768 0.000328478658146725 NA NA NA hsa-miR-15b-5p DCLK1 3.32329949959268 8.40210501034588e-13 -4.71943554274166 0.000191330381389683 miRNATAP -0.698568687601026 2.98036210743714e-06 NA NA NA hsa-miR-21-3p DCP2 3.50297439576639 6.39946844099206e-10 -0.00761082715724815 0.982367942193058 mirMAP -0.12726039337278 0.000125469627379295 NA NA NA hsa-miR-21-5p DDHD2 2.65163477806992 6.72089787690756e-16 -0.76019082841759 0.0408342036153428 miRNAWalker2_validate -0.285200789522351 3.59627111706193e-06 NA NA NA hsa-miR-21-3p DDI2 3.50297439576639 6.39946844099206e-10 1.14077451702781 0.306236508161182 mirMAP -0.218667434045063 0.0449136345555179 NA NA NA hsa-miR-21-5p DDR2 2.65163477806992 6.72089787690756e-16 -4.02032633417406 0.000142582866755554 miRNAWalker2_validate -0.374861111153624 0.0370196550806301 NA NA NA hsa-miR-15b-5p DEF8 3.32329949959268 8.40210501034588e-13 -0.481142298952441 0.19293616269032 MirTarget -0.138049181499615 0.00148890197602313 NA NA NA hsa-miR-15b-5p DENND2C 3.32329949959268 8.40210501034588e-13 1.53782928713607 0.235359868563845 MirTarget -0.331424221997348 0.0311004115596642 NA NA NA hsa-miR-106b-5p DIP2C 2.80565545918114 1.14547999022566e-09 -1.7131692458382 0.000512094839806967 miRNATAP -0.143110244824223 0.017007328534692 NA NA NA hsa-miR-21-3p DISC1 3.50297439576639 6.39946844099206e-10 -0.694732672821584 0.303975860759225 MirTarget -0.377130464981487 4.84062429824119e-09 NA NA NA hsa-miR-106b-5p DIXDC1 2.80565545918114 1.14547999022566e-09 -4.24415941146719 1.24306330392779e-10 mirMAP -0.33689683528457 3.54745366071101e-05 NA NA NA hsa-miR-15b-5p DIXDC1 3.32329949959268 8.40210501034588e-13 -4.24415941146719 1.24306330392779e-10 MirTarget -0.394223191815018 6.91171383201923e-07 NA NA NA hsa-miR-106b-5p DLC1 2.80565545918114 1.14547999022566e-09 -3.66271297046991 8.65727517947362e-07 miRNATAP -0.515414375299275 8.67200275951415e-09 26223867 MicroRNA 106b promotes colorectal cancer cell migration and invasion by directly targeting DLC1; Moreover we identify DLC1 as a direct target of miR-106b reveal its expression to be inversely correlated with miR-106b in CRC samples and show that its re-introduction reverses miR-106b-induced CRC cell migration and invasion; Furthermore survival analyses showed the patients with high mi-106b/low DLC1 had shorter overall survival OS and disease-free survival DFS rates and confirmed miR-106b may be an independent prognostic factor for OS and DFS in CRC patients; Our findings indicate that miR-106b promotes CRC cell migration and invasion by targeting DLC1 cell migration;poor survival colorectal cancer hsa-miR-15b-3p DLG2 3.57530146629867 5.89922785773482e-11 -4.94038732576826 0.000231772195628754 mirMAP -0.70384249364336 1.71095901574137e-07 NA NA NA hsa-miR-21-5p DLGAP1 2.65163477806992 6.72089787690756e-16 -2.47169710306636 0.125219850554392 miRNATAP -0.772495351087024 0.00432612055747286 NA NA NA hsa-miR-15b-5p DLL4 3.32329949959268 8.40210501034588e-13 -2.40940779827278 3.55656079079277e-05 miRNATAP -0.323829778100093 2.62130613528265e-06 NA NA NA hsa-miR-106b-5p DMD 2.80565545918114 1.14547999022566e-09 -4.17977171479125 0.00037283808625733 mirMAP -0.415445241788287 0.00365007880162011 NA NA NA hsa-miR-21-5p DMD 2.65163477806992 6.72089787690756e-16 -4.17977171479125 0.00037283808625733 miRNAWalker2_validate -0.460643941183917 0.0208227117174127 NA NA NA hsa-miR-15b-3p DNM3 3.57530146629867 5.89922785773482e-11 -2.56888304303728 0.000564648070252874 mirMAP -0.403045519326868 6.20331457028984e-08 NA NA NA hsa-miR-106b-5p DOCK4 2.80565545918114 1.14547999022566e-09 -2.11104257159399 0.00042966140172098 MirTarget -0.162930199529854 0.0256962598891466 NA NA NA hsa-miR-15b-5p DOCK4 3.32329949959268 8.40210501034588e-13 -2.11104257159399 0.00042966140172098 MirTarget -0.279173473251899 8.47355582779596e-05 NA NA NA hsa-miR-21-5p DOCK7 2.65163477806992 6.72089787690756e-16 -0.454710268318871 0.270320524190951 miRNAWalker2_validate;miRTarBase -0.146845703778472 0.0337129021841693 NA NA NA hsa-miR-15b-3p DOK6 3.57530146629867 5.89922785773482e-11 -3.25968848455902 0.00030302308881009 mirMAP -0.568068619000301 2.20156882574039e-10 NA NA NA hsa-miR-21-5p DOK6 2.65163477806992 6.72089787690756e-16 -3.25968848455902 0.00030302308881009 mirMAP -0.457061470713018 0.00275269087723268 NA NA NA hsa-miR-21-3p DPY19L3 3.50297439576639 6.39946844099206e-10 -0.0204646017419998 0.976572680548987 mirMAP -0.316410690344583 2.35726746257744e-06 NA NA NA hsa-miR-106b-5p DPYD 2.80565545918114 1.14547999022566e-09 -0.298697699606986 0.707692931731332 MirTarget -0.407371560056287 1.85101794738371e-05 NA NA NA hsa-miR-15b-3p DRP2 3.57530146629867 5.89922785773482e-11 -1.91240250758769 0.00657941206731193 mirMAP -0.15662911270166 0.0284172560007959 NA NA NA hsa-miR-15b-5p DSEL 3.32329949959268 8.40210501034588e-13 -3.18367942227931 0.00165073133206986 MirTarget;miRNATAP -0.275660539045274 0.0224496493203618 NA NA NA hsa-miR-106b-5p DSTYK 2.80565545918114 1.14547999022566e-09 -0.943028883658264 0.00369105021749559 miRNATAP -0.105872959210178 0.00689745240550714 NA NA NA hsa-miR-30a-5p DTL -0.768430903969183 0.320487552854215 4.63887791906927 5.75222952375238e-35 miRNAWalker2_validate;miRTarBase -0.113208359333165 0.000230892609132112 22287560 MiR 30a 5p suppresses tumor growth in colon carcinoma by targeting DTL; Subsequent reporter gene assays confirmed the predicted miR-30a-5p binding site in the 3'untranslated region of DTL; In conclusion our data identified miR-30a-5p as a tumor-suppressing miRNA in colon cancer cells exerting its function via modulation of DTL expression which is frequently overexpressed in colorectal cancer colon cancer hsa-miR-21-3p DTNA 3.50297439576639 6.39946844099206e-10 -4.4409941444297 4.24498853318621e-05 mirMAP -0.652473252708195 4.19142191741697e-10 NA NA NA hsa-miR-21-5p DUSP8 2.65163477806992 6.72089787690756e-16 -1.69759743607935 0.0131701427362937 miRNAWalker2_validate;MirTarget -0.409307389673946 0.000362711577974833 NA NA NA hsa-miR-99a-5p DUSP9 -2.72139054000803 0.00621971944534118 6.66211743900964 3.77572698642381e-05 mirMAP -0.263227595668982 0.00449400365998385 NA NA NA hsa-miR-21-3p DYNC1I1 3.50297439576639 6.39946844099206e-10 -2.7683005768424 0.0629318850142809 MirTarget -0.65329674776564 5.66786662384428e-06 NA NA NA hsa-miR-21-3p EBF3 3.50297439576639 6.39946844099206e-10 -3.11989009230029 0.0118470599342362 mirMAP -0.470587595915544 9.62218116016044e-05 NA NA NA hsa-miR-10b-3p ECT2 -2.5229705007884 2.80982573906242e-06 3.71139743984823 5.51478891572504e-16 MirTarget -0.12626021920155 0.0117810549401996 NA NA NA hsa-miR-140-5p ECT2 -0.634610285725923 0.126670572966239 3.71139743984823 5.51478891572504e-16 miRanda -0.15856958740375 0.0172181705275976 NA NA NA hsa-miR-664a-3p ECT2 0.249882351950296 0.56171157318348 3.71139743984823 5.51478891572504e-16 MirTarget;mirMAP -0.141143550974069 0.0281577858419153 NA NA NA hsa-miR-106b-5p EDA2R 2.80565545918114 1.14547999022566e-09 -4.26507150769467 7.27212862735141e-05 MirTarget -0.518410889031604 6.97124572893278e-05 NA NA NA hsa-miR-330-5p EDN3 2.25110496739954 0.000275527655397415 -3.45907207036629 0.038887455524764 miRanda -0.612014367065887 5.49256580401491e-05 NA NA NA hsa-miR-15b-3p EDNRA 3.57530146629867 5.89922785773482e-11 -3.86396581658458 1.2253716357431e-05 mirMAP -0.52671706319015 2.56648158181141e-09 NA NA NA hsa-miR-106b-5p EEA1 2.80565545918114 1.14547999022566e-09 -0.242947212592193 0.598572122813355 MirTarget;miRNATAP -0.247391735414494 6.6244758286561e-06 NA NA NA hsa-miR-21-3p EEF2K 3.50297439576639 6.39946844099206e-10 -0.494558591034672 0.113710817692065 MirTarget -0.102900002601523 0.000663627251253142 NA NA NA hsa-miR-106b-5p EGR2 2.80565545918114 1.14547999022566e-09 -1.38884404958121 0.0932343699878996 MirTarget;miRNATAP -0.325307659007974 0.00109628586782545 NA NA NA hsa-miR-21-5p EIF1AX 2.65163477806992 6.72089787690756e-16 -0.404187198783909 0.174341270727174 miRNATAP -0.214613477780621 1.25549927763723e-05 NA NA NA hsa-miR-99a-5p EIF5A -2.72139054000803 0.00621971944534118 0.775698341437094 0.0470080068716334 miRNAWalker2_validate -0.102445875166188 2.61936443886019e-06 NA NA NA hsa-miR-106b-5p ELAVL2 2.80565545918114 1.14547999022566e-09 1.95321662505849 0.322716473884614 MirTarget;miRNATAP -0.514287032428495 0.0313319177997252 NA NA NA hsa-miR-106b-5p ELK3 2.80565545918114 1.14547999022566e-09 -0.79092498872197 0.293399668627417 miRNAWalker2_validate;MirTarget;miRNATAP -0.360393768592545 6.3656536094956e-05 NA NA NA hsa-miR-15b-5p ELL 3.32329949959268 8.40210501034588e-13 -0.517514537527021 0.0550682204855227 MirTarget;miRNATAP -0.134187536946101 1.95230327305556e-05 NA NA NA hsa-miR-21-3p ELMO1 3.50297439576639 6.39946844099206e-10 -2.10751457575866 0.00200044172161492 MirTarget -0.27629537612978 3.14522887334415e-05 NA NA NA hsa-miR-146b-5p ENDOU 1.87569569182453 0.000737241069698886 -1.70568393178367 0.28835049923699 miRanda -0.335712217344113 0.0404536293799066 NA NA NA hsa-miR-26b-3p ENDOU 0.985177548213122 0.0351427970185971 -1.70568393178367 0.28835049923699 miRNATAP -0.509445416653958 0.00942767624037868 NA NA NA hsa-miR-335-5p ENDOU 0.167216045757305 0.803897055331049 -1.70568393178367 0.28835049923699 miRNAWalker2_validate -0.630999515327444 2.50319081719523e-06 NA NA NA hsa-miR-491-5p ENDOU 0.569358547192776 0.313310594748302 -1.70568393178367 0.28835049923699 miRanda -0.442444037239516 0.00719022026224028 NA NA NA hsa-miR-106b-5p ENPP1 2.80565545918114 1.14547999022566e-09 -5.24750670802769 5.42616283464376e-06 mirMAP -0.389536712609733 0.00587451144573554 NA NA NA hsa-miR-106b-5p ENTPD1 2.80565545918114 1.14547999022566e-09 -1.65448165389233 4.89293666031054e-07 mirMAP -0.188057388462116 2.23028565961847e-06 NA NA NA hsa-miR-15b-3p ENTPD1 3.57530146629867 5.89922785773482e-11 -1.65448165389233 4.89293666031054e-07 mirMAP -0.175877992694757 1.06644180961089e-07 NA NA NA hsa-miR-15b-5p ENTPD1 3.32329949959268 8.40210501034588e-13 -1.65448165389233 4.89293666031054e-07 MirTarget -0.219745838280847 1.33019102988742e-08 NA NA NA hsa-miR-21-3p ENTPD1 3.50297439576639 6.39946844099206e-10 -1.65448165389233 4.89293666031054e-07 mirMAP -0.177860304295383 2.48954730540237e-08 NA NA NA hsa-miR-21-3p EOMES 3.50297439576639 6.39946844099206e-10 0.467169356375974 0.680327573446778 MirTarget -0.318364614335182 0.0039368499808455 NA NA NA hsa-miR-106b-5p EPB41L1 2.80565545918114 1.14547999022566e-09 0.129958087390375 0.826679476152995 mirMAP -0.229333161472311 0.0012917375000876 NA NA NA hsa-miR-15b-5p EPB41L1 3.32329949959268 8.40210501034588e-13 0.129958087390375 0.826679476152995 MirTarget -0.166198686759307 0.0178566208927437 NA NA NA hsa-miR-15b-5p EPB41L5 3.32329949959268 8.40210501034588e-13 -1.32501741875163 0.0198912428649371 MirTarget -0.207373055575847 0.00207616781519625 NA NA NA hsa-miR-21-3p EPC2 3.50297439576639 6.39946844099206e-10 -0.603752419280081 0.0600575049140006 MirTarget -0.103006502295347 0.000923876499966827 NA NA NA hsa-miR-106b-5p EPHA4 2.80565545918114 1.14547999022566e-09 -1.24015169931915 0.242903740927667 miRNATAP -0.375797154936236 0.00332897075846607 NA NA NA hsa-miR-21-5p EPHA4 2.65163477806992 6.72089787690756e-16 -1.24015169931915 0.242903740927667 miRNAWalker2_validate;miRNATAP -0.399196188203059 0.0254099925603793 NA NA NA hsa-miR-106b-5p EPHA7 2.80565545918114 1.14547999022566e-09 -3.76640291452417 0.0202651645424865 miRNATAP -0.402664064746187 0.0409455420250232 NA NA NA hsa-miR-15b-5p EPHA7 3.32329949959268 8.40210501034588e-13 -3.76640291452417 0.0202651645424865 miRNATAP -0.773557168702795 5.26177781333143e-05 NA NA NA hsa-miR-21-5p EPM2A 2.65163477806992 6.72089787690756e-16 -2.01264004583186 1.07379258510578e-07 miRNAWalker2_validate -0.247748649851439 0.000117055061460418 NA NA NA hsa-miR-21-3p EPM2AIP1 3.50297439576639 6.39946844099206e-10 -1.01020901676505 0.0314338843922967 MirTarget -0.129611565594241 0.00464067852846395 NA NA NA hsa-let-7f-1-3p ESR1 1.61507869803314 0.00069342464777815 -4.86690904031832 8.7202896036005e-05 mirMAP -0.514137094390711 0.000593004570041214 NA NA NA hsa-miR-107 ESR1 1.49443409571439 0.000130594521065411 -4.86690904031832 8.7202896036005e-05 PITA;miRanda;miRNATAP -0.485199779771291 0.00802386937321707 26033453 Estrogen-receptor negative tumors displayed higher concentrations of circulating miR-107 than their counterparts p = 0.035; However overexpression of miR-107 in MCF-7 cells did not downregulate estrogen receptor protein breast cancer hsa-miR-130b-3p ESR1 3.9204771543282 1.2714917955808e-11 -4.86690904031832 8.7202896036005e-05 miRNATAP -0.655531460812831 1.96983090557152e-08 NA NA NA hsa-miR-130b-5p ESR1 3.74118449312296 2.92266550966038e-10 -4.86690904031832 8.7202896036005e-05 mirMAP -0.455809114251492 8.36234507102764e-05 NA NA NA hsa-miR-17-5p ESR1 2.3269271449522 2.13987445663942e-05 -4.86690904031832 8.7202896036005e-05 TargetScan -0.713545986675906 1.62065827217932e-08 NA NA NA hsa-miR-181b-5p ESR1 1.11397227523501 0.0273417050354018 -4.86690904031832 8.7202896036005e-05 miRNATAP -0.309200178260973 0.0292535947006713 NA NA NA hsa-miR-188-5p ESR1 1.39111178824125 0.0251592818948912 -4.86690904031832 8.7202896036005e-05 PITA;miRNATAP -0.292264661546384 0.0111392777116078 NA NA NA hsa-miR-18a-3p ESR1 3.64944956993027 7.20156641833731e-07 -4.86690904031832 8.7202896036005e-05 miRNATAP -0.583869834391471 3.48885979705821e-10 19027010;24975878 MicroRNA 18a prevents estrogen receptor alpha expression promoting proliferation of hepatocellular carcinoma cells; The gene ESR1 which encodes the estrogen receptor-alpha ERalpha was identified as a target of miR-18a miR-18a can repress ERalpha translation by binding to its mRNA at the 3' untranslated region;Elevated p53 promotes the processing of miR 18a to decrease estrogen receptor α in female hepatocellular carcinoma; Our previous study identified that estrogen receptor alpha ERα protein is downregulated in 60% of female HCC cases via a miR-18a elevation mediated suppression of ERα translation ; liver cancer;liver cancer hsa-miR-18a-5p ESR1 3.90770175770219 9.15298615034137e-10 -4.86690904031832 8.7202896036005e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.717682404090705 8.92853586579972e-12 19027010;24975878 MicroRNA 18a prevents estrogen receptor alpha expression promoting proliferation of hepatocellular carcinoma cells; The gene ESR1 which encodes the estrogen receptor-alpha ERalpha was identified as a target of miR-18a miR-18a can repress ERalpha translation by binding to its mRNA at the 3' untranslated region;Elevated p53 promotes the processing of miR 18a to decrease estrogen receptor α in female hepatocellular carcinoma; Our previous study identified that estrogen receptor alpha ERα protein is downregulated in 60% of female HCC cases via a miR-18a elevation mediated suppression of ERα translation ; liver cancer;liver cancer hsa-miR-193a-3p ESR1 0.646392169474854 0.207134343676122 -4.86690904031832 8.7202896036005e-05 miRanda -0.511190500796144 0.000237056616525916 NA NA NA hsa-miR-193a-5p ESR1 0.511907930518603 0.239278601221583 -4.86690904031832 8.7202896036005e-05 miRNATAP -0.327513077495101 0.0483894405315943 NA NA NA hsa-miR-193b-3p ESR1 1.35015762547152 0.0874921379319504 -4.86690904031832 8.7202896036005e-05 miRNAWalker2_validate;miRTarBase -0.283864289994699 0.00155428071406592 NA NA NA hsa-miR-19a-3p ESR1 2.17020503944519 0.00122084653711062 -4.86690904031832 8.7202896036005e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.405854302370221 0.000107064903161259 26416600 We speculate that miR-19a might be co-expressed with lncRNA-DLEU1 to co-regulate the expression of ESR1 which influences the occurrence and development of breast cancer cells with different levels of ER expression breast cancer hsa-miR-19b-3p ESR1 1.67581705793313 0.000858910586302716 -4.86690904031832 8.7202896036005e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.60105380943815 1.79568017379388e-05 NA NA NA hsa-miR-21-3p ESR1 3.50297439576639 6.39946844099206e-10 -4.86690904031832 8.7202896036005e-05 mirMAP -0.480833423296416 7.65411212149843e-05 19264808;25337203;25969534;21131358 miR-21 is higher in ER alpha positive than negative tumors but no one has examined how estradiol E2 regulates miR-21 in breast cancer cells; The E2-induced reduction in miR-21 was inhibited by 4-hydroxytamoxifen 4-OHT ICI 182 780 Faslodex and siRNA ER alpha indicating that the suppression is ER alpha-mediated; ER alpha and ER beta agonists PPT and DPN inhibited and 4-OHT increased miR-21 expression; These results are the first to demonstrate that E2 represses the expression of an oncogenic miRNA miR-21 by activating estrogen receptor in MCF-7 cells;Odds ratios ORs showed that miR-21 expression was closely associated with estrogen receptor ER progesterone receptor PR lymph node metastasis histological grade Her2/neu;Dehydroepiandrosterone Activation of G protein coupled Estrogen Receptor Rapidly Stimulates MicroRNA 21 Transcription in Human Hepatocellular Carcinoma Cells;Induction of miR 21 by retinoic acid in estrogen receptor positive breast carcinoma cells: biological correlates and molecular targets ;metastasis;; breast cancer;breast cancer;liver cancer;breast cancer hsa-miR-221-3p ESR1 0.94082283577318 0.174749164179978 -4.86690904031832 8.7202896036005e-05 miRNAWalker2_validate;miRNATAP -0.302301623908009 0.00321441259886049 25483016 HBx protein induced upregulation of microRNA 221 promotes aberrant proliferation in HBV‑related hepatocellular carcinoma by targeting estrogen receptor α liver cancer hsa-miR-222-3p ESR1 1.54730827524553 0.0223014220569407 -4.86690904031832 8.7202896036005e-05 miRNAWalker2_validate;miRNATAP -0.357204786291609 0.000633267376458044 NA NA NA hsa-miR-301a-3p ESR1 1.99338115332667 0.000813358604963724 -4.86690904031832 8.7202896036005e-05 miRNATAP -0.523444440231024 8.82962389888209e-06 NA NA NA hsa-miR-31-5p ESR1 7.15600983164746 6.64190917357724e-10 -4.86690904031832 8.7202896036005e-05 mirMAP -0.189159762913274 0.00142316813494139 23162645 miR 155 and miR 31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status; The expression levels of miR-155 but not miR-31 were inversely correlated with estrogen receptor ER and progesterone receptor PR expression ER r=-0.353 P=0.003; PR r=-0.357 P=0.003 breast cancer hsa-miR-32-3p ESR1 2.20477794939766 0.0392771274032852 -4.86690904031832 8.7202896036005e-05 mirMAP -0.59817971149829 2.15750556270861e-07 NA NA NA hsa-miR-324-5p ESR1 1.31253452379847 0.0116806680545163 -4.86690904031832 8.7202896036005e-05 PITA -0.475777913868801 0.000489638440697562 NA NA NA hsa-miR-330-3p ESR1 2.49094236945806 0.000129367003214715 -4.86690904031832 8.7202896036005e-05 PITA;mirMAP;miRNATAP -0.397708600890597 0.000236939178650417 NA NA NA hsa-miR-33a-3p ESR1 2.06269680799532 0.00156436055383943 -4.86690904031832 8.7202896036005e-05 mirMAP -0.296059334227297 0.00664032513030919 NA NA NA hsa-miR-454-3p ESR1 1.40269869979902 0.00366085847011367 -4.86690904031832 8.7202896036005e-05 miRNATAP -0.516793315507578 0.000445580599137433 NA NA NA hsa-miR-589-3p ESR1 1.33205316880069 0.052632683806148 -4.86690904031832 8.7202896036005e-05 mirMAP -0.340317409332972 0.00104752602019396 NA NA NA hsa-miR-590-3p ESR1 2.35429565068338 2.79601879608564e-06 -4.86690904031832 8.7202896036005e-05 miRanda;mirMAP;miRNATAP -0.463861514380681 0.000908763868927978 NA NA NA hsa-miR-629-3p ESR1 3.48282157979573 4.9176538695908e-08 -4.86690904031832 8.7202896036005e-05 mirMAP -0.516955725298526 1.61749033557232e-06 NA NA NA hsa-miR-7-5p ESR1 3.59831747997243 0.000676336260217879 -4.86690904031832 8.7202896036005e-05 mirMAP -0.450881235625743 2.24150817461406e-08 NA NA NA hsa-miR-9-3p ESR1 1.69328215716742 0.125170982657059 -4.86690904031832 8.7202896036005e-05 mirMAP -0.241531536309251 0.000198853044511084 22723919 Higher expression of miR-9 was significantly associated with breast cancer LR in all cases as well as the subset of estrogen receptor ER positive cases p = 0.02 breast cancer hsa-miR-9-5p ESR1 1.79620806707734 0.14526963042518 -4.86690904031832 8.7202896036005e-05 mirMAP;miRNATAP -0.187629221521367 0.00105945038085064 22723919 Higher expression of miR-9 was significantly associated with breast cancer LR in all cases as well as the subset of estrogen receptor ER positive cases p = 0.02 breast cancer hsa-miR-21-5p ETNK1 2.65163477806992 6.72089787690756e-16 -0.0201793236358334 0.961466913292616 miRNAWalker2_validate -0.167478423079442 0.0165590672515592 NA NA NA hsa-miR-106b-5p ETV1 2.80565545918114 1.14547999022566e-09 -1.44283594373238 0.120874836553272 MirTarget;miRNATAP -0.429090887270151 0.000121315717259993 NA NA NA hsa-miR-21-3p ETV1 3.50297439576639 6.39946844099206e-10 -1.44283594373238 0.120874836553272 MirTarget -0.359873794711494 6.57750682352509e-05 NA NA NA hsa-miR-15b-5p EXOC3L2 3.32329949959268 8.40210501034588e-13 -2.76773773437567 5.57995546279289e-06 miRNATAP -0.39117877894217 5.20748865879647e-08 NA NA NA hsa-miR-106b-5p EZH1 2.80565545918114 1.14547999022566e-09 -1.80185014950928 1.19605554233324e-09 MirTarget;miRNATAP -0.144072266166648 7.19233971276926e-05 NA NA NA hsa-miR-15b-5p EZH1 3.32329949959268 8.40210501034588e-13 -1.80185014950928 1.19605554233324e-09 MirTarget;miRNATAP -0.141954064656123 6.64330013457134e-05 NA NA NA hsa-let-7e-5p EZH2 -0.111012524740586 0.814744515884005 4.69392322060532 2.43295965973887e-27 miRNATAP -0.209849757668999 0.000228259894141986 NA NA NA hsa-miR-139-5p EZH2 -2.09475477693654 0.000382570602748311 4.69392322060532 2.43295965973887e-27 miRanda -0.150234687909385 0.000873563587418196 NA NA NA hsa-miR-15b-3p F7 3.57530146629867 5.89922785773482e-11 -1.95390648268077 0.119035224484014 mirMAP -0.36705749066892 0.00372159755905175 NA NA NA hsa-miR-106b-5p FAM102A 2.80565545918114 1.14547999022566e-09 -0.0823786931033901 0.85761257092359 miRNATAP -0.16282183367933 0.0031455017036335 NA NA NA hsa-miR-15b-5p FAM102A 3.32329949959268 8.40210501034588e-13 -0.0823786931033901 0.85761257092359 mirMAP -0.124169893540994 0.0220316270117381 NA NA NA hsa-miR-15b-3p FAM110B 3.57530146629867 5.89922785773482e-11 -4.61128879603516 2.88242304017382e-06 MirTarget -0.467839817719853 2.84986582814882e-06 NA NA NA hsa-miR-15b-5p FAM135A 3.32329949959268 8.40210501034588e-13 0.515667136006207 0.48295642683981 miRNATAP -0.212548598105376 0.0145212261597552 NA NA NA hsa-miR-15b-3p FAM26E 3.57530146629867 5.89922785773482e-11 -3.14170309093076 0.000144302221813533 mirMAP -0.27655921866623 0.00100021599828334 NA NA NA hsa-miR-21-5p FAM3C 2.65163477806992 6.72089787690756e-16 -0.673702993020597 0.120627408820581 miRNAWalker2_validate -0.245260237292652 0.000711708022898905 NA NA NA hsa-miR-15b-5p FAM84B 3.32329949959268 8.40210501034588e-13 0.25544766491217 0.611483621359066 MirTarget -0.165743882412924 0.0051990274279793 NA NA NA hsa-miR-15b-5p FAM89A 3.32329949959268 8.40210501034588e-13 -1.64159511749553 0.0809910282091131 MirTarget -0.249783047466229 0.0253105144230089 NA NA NA hsa-miR-140-3p FANCA -1.9828800596692 8.92876132959514e-08 4.779089010945 4.36708709628983e-32 miRNATAP -0.294208865847866 1.45688521143694e-05 NA NA NA hsa-miR-26a-5p FANCA -0.352368463397074 0.362040749917446 4.779089010945 4.36708709628983e-32 miRNATAP -0.13383208439448 0.0467323850698769 NA NA NA hsa-miR-505-5p FANCA -0.548246528900629 0.331409094367131 4.779089010945 4.36708709628983e-32 miRNATAP -0.111097434250053 0.0145739687732782 NA NA NA hsa-miR-542-3p FANCA -0.376147863244659 0.438002751207043 4.779089010945 4.36708709628983e-32 miRanda -0.132636661791741 0.0125368046204281 NA NA NA hsa-miR-106b-5p FAT3 2.80565545918114 1.14547999022566e-09 -3.48327918457969 0.015252000190887 mirMAP -0.631594176534061 0.000262931659197598 NA NA NA hsa-miR-21-3p FAT3 3.50297439576639 6.39946844099206e-10 -3.48327918457969 0.015252000190887 MirTarget -0.605983370461943 1.35656066022542e-05 NA NA NA hsa-miR-106b-5p FAT4 2.80565545918114 1.14547999022566e-09 -3.60080933894453 0.000120643781684891 MirTarget;miRNATAP -0.591809361471109 1.38333675964335e-07 NA NA NA hsa-miR-15b-5p FAT4 3.32329949959268 8.40210501034588e-13 -3.60080933894453 0.000120643781684891 MirTarget -0.482170360586346 1.39488665916078e-05 NA NA NA hsa-miR-106b-5p FBXL3 2.80565545918114 1.14547999022566e-09 -1.13734404331123 0.000886384155874164 miRNATAP -0.142770572692454 0.000535538087917765 NA NA NA hsa-miR-106b-5p FBXL5 2.80565545918114 1.14547999022566e-09 -0.858161835403887 0.00473828027094503 miRNATAP -0.10562843423559 0.00388235422373998 NA NA NA hsa-miR-106b-5p FBXO3 2.80565545918114 1.14547999022566e-09 -0.637895752948657 0.0643439377248326 mirMAP -0.129619274248198 0.00173455916510714 NA NA NA hsa-miR-106b-5p FCHO2 2.80565545918114 1.14547999022566e-09 -0.577391108038341 0.156564928822249 miRNATAP -0.180457272912162 0.000215951037235734 NA NA NA hsa-miR-140-5p FEN1 -0.634610285725923 0.126670572966239 3.0045784299663 2.32847027371709e-19 PITA;miRanda;miRNATAP -0.136289770586794 0.00531318425080468 NA NA NA hsa-miR-15b-5p FERMT2 3.32329949959268 8.40210501034588e-13 -4.36546024261243 6.75771952930767e-07 MirTarget;miRNATAP -0.249142594211613 0.018850073577692 NA NA NA hsa-miR-21-5p FERMT2 2.65163477806992 6.72089787690756e-16 -4.36546024261243 6.75771952930767e-07 miRNAWalker2_validate -0.575916293604471 0.000114981217480358 NA NA NA hsa-miR-106b-5p FGD5 2.80565545918114 1.14547999022566e-09 -3.68112044430381 2.69565787147413e-07 MirTarget;miRNATAP -0.451729896775841 1.86000483635221e-07 NA NA NA hsa-miR-21-5p FGF18 2.65163477806992 6.72089787690756e-16 -3.01542595781322 0.0221151767151304 miRNATAP -0.796731311488867 0.000310248371727273 NA NA NA hsa-miR-15b-3p FGF2 3.57530146629867 5.89922785773482e-11 -4.7426237294682 2.88390048531716e-06 mirMAP -0.251278988211542 0.0158237593305505 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 3.32329949959268 8.40210501034588e-13 -4.7426237294682 2.88390048531716e-06 MirTarget;miRNATAP -0.306797558152995 0.0119476747242703 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-21-5p FGF2 2.65163477806992 6.72089787690756e-16 -4.7426237294682 2.88390048531716e-06 mirMAP -0.567342076857507 0.00100450723749317 NA NA NA hsa-miR-15b-5p FGF5 3.32329949959268 8.40210501034588e-13 0.200823087926326 0.886420744796129 miRNAWalker2_validate -0.334927068379022 0.0445186854987975 NA NA NA hsa-miR-15b-5p FGF7 3.32329949959268 8.40210501034588e-13 -5.50929759175591 2.08834235862861e-09 miRNATAP -0.7640679607102 1.57490618059424e-12 NA NA NA hsa-miR-15b-5p FGF9 3.32329949959268 8.40210501034588e-13 -4.08682393789453 0.0107258337159531 miRNATAP -0.57369666067076 0.00255066397006186 NA NA NA hsa-miR-106b-5p FGFR1 2.80565545918114 1.14547999022566e-09 -3.68099244503292 0.000117634214619712 mirMAP -0.32757862591401 0.00493739743042474 NA NA NA hsa-let-7f-1-3p FGFR2 1.61507869803314 0.00069342464777815 -1.54795077473676 0.070591459239545 mirMAP -0.23351339007373 0.0231277680591286 NA NA NA hsa-miR-146b-5p FGFR2 1.87569569182453 0.000737241069698886 -1.54795077473676 0.070591459239545 miRanda -0.298378342872546 0.000592636062336762 NA NA NA hsa-miR-186-5p FGFR2 0.445443449112564 0.185447310527704 -1.54795077473676 0.070591459239545 miRNAWalker2_validate -0.37063637923109 0.0122530471665904 NA NA NA hsa-miR-324-5p FGFR2 1.31253452379847 0.0116806680545163 -1.54795077473676 0.070591459239545 miRanda -0.219083478056957 0.0194265727951803 NA NA NA hsa-miR-330-5p FGFR2 2.25110496739954 0.000275527655397415 -1.54795077473676 0.070591459239545 miRanda -0.389349119984991 4.06955034955631e-07 NA NA NA hsa-miR-338-3p FGFR2 0.447551118940466 0.558485097370031 -1.54795077473676 0.070591459239545 miRanda;miRNATAP -0.19939075618371 0.00167905513044275 NA NA NA hsa-miR-106b-5p FGL2 2.80565545918114 1.14547999022566e-09 -1.48176667348829 0.102649961954467 MirTarget -0.392557845747256 0.000322239594960604 NA NA NA hsa-miR-106b-5p FHL2 2.80565545918114 1.14547999022566e-09 -1.28411927276246 0.0905920623540858 mirMAP -0.216693012297673 0.0181896510934869 NA NA NA hsa-miR-106b-5p FIBIN 2.80565545918114 1.14547999022566e-09 -3.84663592151213 0.00528242881095334 MirTarget -0.973927931658957 2.61037145556072e-09 NA NA NA hsa-miR-21-5p FILIP1L 2.65163477806992 6.72089787690756e-16 -4.49206953928647 2.40084069376003e-08 miRNAWalker2_validate -0.276517022507981 0.0462171233577058 NA NA NA hsa-miR-106b-5p FMN1 2.80565545918114 1.14547999022566e-09 1.87225758180081 0.0759952287553139 mirMAP -0.309003951669378 0.0154956505696176 NA NA NA hsa-miR-15b-3p FMN1 3.57530146629867 5.89922785773482e-11 1.87225758180081 0.0759952287553139 mirMAP -0.218277549176617 0.0412164463256838 NA NA NA hsa-miR-15b-3p FMO2 3.57530146629867 5.89922785773482e-11 -4.06558770256733 0.0161907057847774 mirMAP -0.898916669923868 9.44332725162411e-08 NA NA NA hsa-miR-21-5p FMOD 2.65163477806992 6.72089787690756e-16 -4.02539650946723 9.51230967918598e-06 miRNAWalker2_validate;miRTarBase -0.587701206119074 0.000134387089916172 19906824;23445447 Gain-of miR-21 function in MSMC and LSMC reduced TGF-beta-induced expression of fibromodulin and TGF-beta-induced factor P < 0.05 and moderately altered the rate of cell growth and caspase-3/7 activity in these cells;Our method exhibits ultrahigh sensitivity toward miR-21 with detection limits of 10 fM at 37 °C and 1 aM at 4 °C which corresponds to nine strands of miR-21 in a 15 μL sample and it is capable of distinguishing among miRNA family members ; sarcoma;breast cancer hsa-miR-106b-5p FNBP1 2.80565545918114 1.14547999022566e-09 -2.26491435787707 3.33641560502842e-08 miRNAWalker2_validate -0.170487852655525 0.000703973195089325 NA NA NA hsa-miR-21-5p FNBP1 2.65163477806992 6.72089787690756e-16 -2.26491435787707 3.33641560502842e-08 miRNAWalker2_validate -0.179510358885078 0.0106453310986577 NA NA NA hsa-miR-106b-5p FNDC3A 2.80565545918114 1.14547999022566e-09 -1.16916980634561 0.0136584014851924 MirTarget;miRNATAP -0.147967512867246 0.00983554445662349 NA NA NA hsa-miR-106b-5p FOXN3 2.80565545918114 1.14547999022566e-09 -1.06802740812212 0.00863544351272114 miRNATAP -0.160605457328687 0.00104271411902683 NA NA NA hsa-miR-21-5p FOXN3 2.65163477806992 6.72089787690756e-16 -1.06802740812212 0.00863544351272114 miRNAWalker2_validate;mirMAP -0.143949188734831 0.0355804742634093 NA NA NA hsa-miR-106b-3p FOXO1 2.57689304590494 1.04870442173494e-07 -2.60585738485417 1.72557412066164e-08 miRNAWalker2_validate -0.191720590179611 0.000415655714873145 NA NA NA hsa-miR-21-5p FOXP2 2.65163477806992 6.72089787690756e-16 -1.88480330838752 0.302620643537055 mirMAP -0.639623900695944 0.0376539289380868 NA NA NA hsa-miR-21-5p FREM2 2.65163477806992 6.72089787690756e-16 -2.95928795484189 0.209631348873923 mirMAP -1.59427754359233 5.0411894495666e-05 NA NA NA hsa-miR-106b-5p FRMD6 2.80565545918114 1.14547999022566e-09 -1.60821237953985 0.0820702410760675 MirTarget;miRNATAP -0.432984917327778 9.61909894505862e-05 NA NA NA hsa-miR-15b-3p FRMD6 3.57530146629867 5.89922785773482e-11 -1.60821237953985 0.0820702410760675 mirMAP -0.222281717935194 0.017546187882109 NA NA NA hsa-miR-15b-5p FRY 3.32329949959268 8.40210501034588e-13 -3.47154242417698 5.20964634283419e-05 miRNATAP -0.242962110361292 0.018210817630261 NA NA NA hsa-miR-106b-5p FTO 2.80565545918114 1.14547999022566e-09 -1.07499067425097 0.000445751394298652 mirMAP -0.108893319567862 0.00323504345042622 NA NA NA hsa-miR-125a-3p FUT6 -0.0748960586927341 0.920735897434087 3.62957389763259 0.0208421150541836 MirTarget;miRanda;miRNATAP -0.352395336682088 0.00305298232451261 NA NA NA hsa-miR-2355-5p FUT6 0.418226038913005 0.502149040287915 3.62957389763259 0.0208421150541836 MirTarget -0.521070475922044 0.000275145558836349 NA NA NA hsa-miR-106b-5p FYCO1 2.80565545918114 1.14547999022566e-09 -1.6483297550543 5.91012193758592e-05 MirTarget -0.217804965825655 1.06436506055442e-05 NA NA NA hsa-miR-106b-5p FYN 2.80565545918114 1.14547999022566e-09 -2.7034719817623 4.90203255667929e-05 miRNATAP -0.17166081218377 0.0350643401222063 NA NA NA hsa-miR-15b-5p FZD4 3.32329949959268 8.40210501034588e-13 -2.83886953461754 3.72732903465121e-05 MirTarget -0.282999459031275 0.000569874909623984 NA NA NA hsa-miR-99a-5p FZD5 -2.72139054000803 0.00621971944534118 0.640287282353737 0.297444783437361 MirTarget;miRNATAP -0.125875532977723 0.000270995390359697 NA NA NA hsa-miR-106b-5p GAB1 2.80565545918114 1.14547999022566e-09 -1.62977330271772 0.000142750673779243 MirTarget;miRNATAP -0.183117199194944 0.000416117117794602 NA NA NA hsa-miR-15b-3p GAB1 3.57530146629867 5.89922785773482e-11 -1.62977330271772 0.000142750673779243 mirMAP -0.144033012305274 0.000916105760435352 NA NA NA hsa-miR-15b-5p GALNT13 3.32329949959268 8.40210501034588e-13 -4.45039573333608 0.000487469288936641 MirTarget -0.630196169119369 3.04837655216946e-05 NA NA NA hsa-miR-106b-5p GAS7 2.80565545918114 1.14547999022566e-09 -3.04844932705412 0.000206648898538204 mirMAP -0.612219322779998 3.45541588507578e-10 NA NA NA hsa-miR-21-5p GAS7 2.65163477806992 6.72089787690756e-16 -3.04844932705412 0.000206648898538204 mirMAP -0.313361421661743 0.0246736139573353 NA NA NA hsa-miR-106b-5p GBP4 2.80565545918114 1.14547999022566e-09 0.547795633745175 0.600146675214514 mirMAP -0.476474415827494 0.000142442893394529 NA NA NA hsa-miR-106b-5p GCNT4 2.80565545918114 1.14547999022566e-09 -0.700442950609293 0.438660931281286 MirTarget -0.342068655599517 0.00166919950250789 NA NA NA hsa-miR-21-3p GCOM1 3.50297439576639 6.39946844099206e-10 -3.76420502341066 0.000399006693700327 MirTarget -0.284334671762408 0.00658400902880131 NA NA NA hsa-miR-106b-5p GFRA1 2.80565545918114 1.14547999022566e-09 -6.71676086795115 2.48870271326987e-07 mirMAP -1.11955321739197 4.55471466723196e-13 NA NA NA hsa-miR-15b-3p GFRA1 3.57530146629867 5.89922785773482e-11 -6.71676086795115 2.48870271326987e-07 mirMAP -0.987230512398645 1.73107561427041e-14 NA NA NA hsa-miR-15b-5p GFRA2 3.32329949959268 8.40210501034588e-13 -3.21992440936948 0.00388521546214919 mirMAP -0.582564821281496 9.28923798082482e-06 NA NA NA hsa-miR-21-3p GFRA2 3.50297439576639 6.39946844099206e-10 -3.21992440936948 0.00388521546214919 MirTarget -0.519045707584638 1.54767561060381e-06 NA NA NA hsa-miR-15b-5p GHR 3.32329949959268 8.40210501034588e-13 -3.30441572530682 0.0133498021134927 MirTarget;miRNATAP -0.517993741994565 0.00106382975468503 NA NA NA hsa-miR-15b-3p GIPC3 3.57530146629867 5.89922785773482e-11 -2.4857623959477 0.000135954114361432 mirMAP -0.36509336805504 2.06332400313729e-08 NA NA NA hsa-miR-21-3p GJC1 3.50297439576639 6.39946844099206e-10 -2.92001163442114 0.000785414331230878 mirMAP -0.30038046443142 0.000418086209192869 NA NA NA hsa-miR-21-3p GNAZ 3.50297439576639 6.39946844099206e-10 -3.83275559415735 0.000559496423958994 MirTarget -0.41704471337586 0.000123553454731662 NA NA NA hsa-miR-106b-5p GNE 2.80565545918114 1.14547999022566e-09 -1.11263617735981 0.122646167315013 mirMAP -0.197259934089012 0.0235825182397981 NA NA NA hsa-miR-15b-3p GPC6 3.57530146629867 5.89922785773482e-11 -2.96127859952068 0.0127527917814679 MirTarget -0.554363753213998 3.24918610087747e-06 NA NA NA hsa-miR-106b-5p GPM6A 2.80565545918114 1.14547999022566e-09 -8.84059407174405 1.11545156178103e-11 miRNAWalker2_validate -0.736761351067907 4.78239765227425e-06 NA NA NA hsa-miR-106b-5p GPR137B 2.80565545918114 1.14547999022566e-09 -0.65522054587066 0.110724238475602 miRNATAP -0.172725402631192 0.00045267194481496 NA NA NA hsa-miR-15b-5p GPR153 3.32329949959268 8.40210501034588e-13 -0.28809432247998 0.700653658862604 miRNATAP -0.187101966973646 0.0350189924492071 NA NA NA hsa-miR-21-3p GPRASP2 3.50297439576639 6.39946844099206e-10 -3.06519822209201 1.39829838724573e-07 MirTarget -0.251185350569173 1.19708192916416e-05 NA NA NA hsa-miR-15b-5p GRAMD3 3.32329949959268 8.40210501034588e-13 -1.71449555143497 0.000359671526652408 MirTarget -0.20438858677213 0.000336182825995476 NA NA NA hsa-miR-15b-3p GREM1 3.57530146629867 5.89922785773482e-11 -1.90177748877488 0.0936801310258417 mirMAP -0.419947632860335 0.000232077273547984 NA NA NA hsa-miR-106b-5p GREM2 2.80565545918114 1.14547999022566e-09 -5.64729272277079 1.72451371347501e-06 mirMAP -0.686008824435792 1.64901907083761e-06 NA NA NA hsa-miR-15b-3p GREM2 3.57530146629867 5.89922785773482e-11 -5.64729272277079 1.72451371347501e-06 mirMAP -0.581261238074814 1.19294879863427e-06 NA NA NA hsa-miR-21-5p GRIK3 2.65163477806992 6.72089787690756e-16 -1.00311199889307 0.38687330274231 mirMAP -0.443031439745812 0.0229875178111535 NA NA NA hsa-miR-15b-3p GRIN2A 3.57530146629867 5.89922785773482e-11 -3.41877778367476 0.0449092732676301 mirMAP -0.431251096984001 0.0124958833677871 NA NA NA hsa-miR-21-3p GTF2A1 3.50297439576639 6.39946844099206e-10 1.31487531340527 0.135021738721304 MirTarget -0.245930305340859 0.00415061806224865 NA NA NA hsa-miR-15b-3p H6PD 3.57530146629867 5.89922785773482e-11 -1.39631579281637 0.00141412021242914 mirMAP -0.121660374785187 0.00606637753723294 NA NA NA hsa-miR-15b-5p HAPLN4 3.32329949959268 8.40210501034588e-13 -3.15623021675864 0.000735842174945665 MirTarget -0.439089225195609 7.3727500262536e-05 NA NA NA hsa-miR-106b-5p HAS2 2.80565545918114 1.14547999022566e-09 -0.872227689542701 0.541811136420738 MirTarget -0.422966112262764 0.0142705799812301 NA NA NA hsa-miR-15b-5p HAS2 3.32329949959268 8.40210501034588e-13 -0.872227689542701 0.541811136420738 MirTarget -0.601917427324423 0.000350028308442147 NA NA NA hsa-miR-21-5p HBP1 2.65163477806992 6.72089787690756e-16 -1.12609848594608 6.33680883362028e-05 miRNATAP -0.117842572375728 0.0130766767924049 26282675 MicroRNA 21 is a potential link between non alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1 p53 Srebp1c pathway; Further studies revealed that Hbp1 was a novel target of microRNA-21 and a transcriptional activator of p53 liver cancer hsa-miR-106b-5p HEG1 2.80565545918114 1.14547999022566e-09 -1.10827785583838 0.15703413197601 miRNATAP -0.488641284290082 1.47117041853097e-07 NA NA NA hsa-miR-15b-3p HEYL 3.57530146629867 5.89922785773482e-11 -3.76008965775318 8.52763734301556e-07 mirMAP -0.332287083358959 1.94225848930799e-05 NA NA NA hsa-miR-15b-3p HHIP 3.57530146629867 5.89922785773482e-11 -3.25832572720499 0.0274932440392049 mirMAP -0.383289311278139 0.0104814903202441 NA NA NA hsa-miR-21-5p HHIP 2.65163477806992 6.72089787690756e-16 -3.25832572720499 0.0274932440392049 mirMAP -0.541874116728409 0.0298094937785642 NA NA NA hsa-miR-15b-5p HHIPL1 3.32329949959268 8.40210501034588e-13 -2.48177569833478 0.0131383148382097 mirMAP -0.260685989657571 0.0286463321760609 NA NA NA hsa-miR-21-3p HIPK1 3.50297439576639 6.39946844099206e-10 0.00558773965334325 0.988024384959061 MirTarget -0.15109949460145 2.45003671406855e-05 NA NA NA hsa-miR-21-3p HIPK2 3.50297439576639 6.39946844099206e-10 -0.161532943638135 0.779163338892275 mirMAP -0.312524141744073 1.27602412143519e-08 NA NA NA hsa-miR-106b-5p HLA-DOA 2.80565545918114 1.14547999022566e-09 -1.18979259166777 0.281189206188745 mirMAP -0.352201231187504 0.00821123851604198 NA NA NA hsa-miR-106b-5p HLF 2.80565545918114 1.14547999022566e-09 -4.18397758396876 0.000426403354693301 MirTarget;miRNATAP -0.44709447714555 0.00195100493083584 NA NA NA hsa-miR-99a-5p HOXA1 -2.72139054000803 0.00621971944534118 2.61084672918287 0.00724577998548951 miRNATAP -0.278344207840366 3.1935381344845e-07 26417931 MicroRNA 99a inhibits tumor aggressive phenotypes through regulating HOXA1 in breast cancer cells; An integrated bioinformatics analysis identified HOXA1 mRNA as the direct functional target of miR-99a and this regulation was confirmed by luciferase reporter assay; Knockdown of HOXA1 significantly inhibited breast cancer cell proliferation migration and invasion and restoration of HOXA1 partially rescued the inhibitory effect of miR-99a in breast cancer cells breast cancer hsa-miR-15b-5p HPSE2 3.32329949959268 8.40210501034588e-13 -5.91831248836279 2.5665288046231e-06 MirTarget -0.603830072319784 5.9464099917135e-05 NA NA NA hsa-miR-21-3p HSD17B11 3.50297439576639 6.39946844099206e-10 -2.73969975871973 6.1922517972539e-05 MirTarget -0.207781206752996 0.0020329681554519 NA NA NA hsa-miR-15b-5p HSPG2 3.32329949959268 8.40210501034588e-13 -1.6437917679296 0.00138140880727578 MirTarget -0.191209988890728 0.00172502820897976 NA NA NA hsa-miR-324-5p IFI44 1.31253452379847 0.0116806680545163 2.00705459631233 0.0346094276858752 miRanda -0.405218258177771 8.73837019273608e-05 NA NA NA hsa-miR-589-3p IFI44 1.33205316880069 0.052632683806148 2.00705459631233 0.0346094276858752 MirTarget -0.277006715571449 0.000431238208944613 NA NA NA hsa-miR-616-5p IFI6 2.48416313933027 0.00318247475868827 1.65440445620905 0.109311921278078 MirTarget -0.21624747012529 0.0128742826381652 NA NA NA hsa-miR-106b-5p IFNAR2 2.80565545918114 1.14547999022566e-09 -0.0533929917619993 0.876582967690528 miRNAWalker2_validate -0.104660115738333 0.0111795305968606 NA NA NA hsa-miR-15b-3p IGF1 3.57530146629867 5.89922785773482e-11 -4.48455379412262 0.00149155200072234 mirMAP -0.729097685666816 2.48630408177257e-07 NA NA NA hsa-miR-99a-5p IGF1R -2.72139054000803 0.00621971944534118 -0.352375681657302 0.589588982107528 miRNAWalker2_validate;miRTarBase;miRNATAP -0.160661156530045 1.10343858783123e-05 22425712 Furthermore ectopic transfection of miR-99 family members down-regulated the expression of insulin-like growth factor 1 receptor IGF1R and mechanistic target of rapamycin mTOR genes; The deregulation of miR-99 family contributes to the tumorigenesis of HNSCC in part by targeting IGF1R and mTOR signaling pathways tumorigenesis head and neck cancer hsa-miR-15b-3p IGFBP5 3.57530146629867 5.89922785773482e-11 -4.69502357823987 0.000126115880205647 mirMAP -0.455825674226829 0.000246516975264058 NA NA NA hsa-miR-15b-5p IGSF9B 3.32329949959268 8.40210501034588e-13 -4.322107188909 0.00109522479147968 mirMAP -0.401437645541716 0.0110598363539345 NA NA NA hsa-miR-106b-5p IKZF2 2.80565545918114 1.14547999022566e-09 2.49301346714518 0.00194998757127006 mirMAP;miRNATAP -0.314606902919599 0.00124794234905414 NA NA NA hsa-miR-106b-5p IKZF4 2.80565545918114 1.14547999022566e-09 -1.1073224528622 0.00184031508635915 MirTarget;miRNATAP -0.111804684074773 0.00931956614525856 NA NA NA hsa-miR-15b-3p IL16 3.57530146629867 5.89922785773482e-11 -1.48125703851106 0.0271935365233208 mirMAP -0.268650105868008 6.64068881146462e-05 NA NA NA hsa-miR-21-3p IL17RD 3.50297439576639 6.39946844099206e-10 -3.56191756608938 5.09134923896378e-06 mirMAP -0.260880079480472 0.000713941470387151 NA NA NA hsa-miR-21-5p ING3 2.65163477806992 6.72089787690756e-16 -0.628404393558933 0.0739661690741666 MirTarget -0.253960956616503 1.3126444219696e-05 NA NA NA hsa-miR-10a-3p INHBA 0.970411431936568 0.31667483998251 0.597174749350624 0.643310167999085 mirMAP -0.228868949828328 0.00288571997624358 NA NA NA hsa-miR-10b-5p INHBA -3.08172917642729 4.22675074435126e-09 0.597174749350624 0.643310167999085 miRNAWalker2_validate -0.375135520462904 0.00596419514318865 NA NA NA hsa-miR-125b-2-3p INHBA -1.75609980210443 0.122616157214143 0.597174749350624 0.643310167999085 mirMAP -0.157944790930006 0.0138376865661889 NA NA NA hsa-miR-148b-3p INHBA 1.75622244535669 8.84414356040579e-08 0.597174749350624 0.643310167999085 miRNAWalker2_validate -0.667439513931159 0.00272176813701307 NA NA NA hsa-miR-16-2-3p INHBA 3.79845098071094 1.49120139344659e-13 0.597174749350624 0.643310167999085 mirMAP -0.460254491787022 0.000754313391824958 NA NA NA hsa-miR-181c-5p INHBA -0.302833440762172 0.537532549455539 0.597174749350624 0.643310167999085 mirMAP -0.327187664106844 0.0295723539209472 NA NA NA hsa-miR-195-3p INHBA -2.39100534119332 0.000185405399054065 0.597174749350624 0.643310167999085 mirMAP -0.359920153494247 0.00156804274458257 NA NA NA hsa-miR-200b-3p INHBA 5.56167217794639 6.43540045061709e-16 0.597174749350624 0.643310167999085 TargetScan -0.556231875088492 1.97398662453022e-08 NA NA NA hsa-miR-224-3p INHBA 2.84876340814503 0.000179138399939161 0.597174749350624 0.643310167999085 mirMAP -0.244901176503382 0.0107132106449266 NA NA NA hsa-miR-26a-5p INHBA -0.352368463397074 0.362040749917446 0.597174749350624 0.643310167999085 mirMAP -0.482333762837731 0.0121541790978987 NA NA NA hsa-miR-3065-5p INHBA 2.14185373842821 0.0609400502269891 0.597174749350624 0.643310167999085 mirMAP -0.362079017770634 4.04665334650244e-06 NA NA NA hsa-miR-30b-5p INHBA 0.0238659735605804 0.953223658270319 0.597174749350624 0.643310167999085 mirMAP -0.641790503573834 0.00040859319409002 NA NA NA hsa-miR-30c-5p INHBA 0.38723991118075 0.348605235643473 0.597174749350624 0.643310167999085 mirMAP -0.829638986336471 2.85124185439564e-06 NA NA NA hsa-miR-30d-5p INHBA 0.302504510257496 0.380193536606962 0.597174749350624 0.643310167999085 mirMAP -0.810002974024271 0.000171793130428081 NA NA NA hsa-miR-30e-5p INHBA 0.780047227271616 0.0346714425913016 0.597174749350624 0.643310167999085 mirMAP -1.27059538225699 7.92305049877725e-11 NA NA NA hsa-miR-3607-3p INHBA 1.38015131722213 0.0240067155694847 0.597174749350624 0.643310167999085 mirMAP -0.386722991000475 0.00117665769481931 NA NA NA hsa-miR-374a-5p INHBA 0.278549982012055 0.45888283715888 0.597174749350624 0.643310167999085 mirMAP -0.531291535768356 0.00725261558931535 NA NA NA hsa-miR-374b-5p INHBA -0.114749866169918 0.764888930049438 0.597174749350624 0.643310167999085 mirMAP -0.397382374555169 0.0408507665343398 NA NA NA hsa-miR-664a-3p INHBA 0.249882351950296 0.56171157318348 0.597174749350624 0.643310167999085 mirMAP -0.466978716274 0.00658510269681794 NA NA NA hsa-miR-21-3p INO80D 3.50297439576639 6.39946844099206e-10 -0.292947079359495 0.422740227731055 MirTarget;mirMAP -0.138350316408076 8.60378452390862e-05 NA NA NA hsa-miR-15b-3p INPP4B 3.57530146629867 5.89922785773482e-11 0.952191545153135 0.334038796172915 mirMAP -0.242049429925477 0.0150500521848212 NA NA NA hsa-miR-15b-3p INSR 3.57530146629867 5.89922785773482e-11 -1.82386828224005 0.000371643290248406 mirMAP -0.215002361054263 3.16844858196134e-05 NA NA NA hsa-miR-15b-5p INSR 3.32329949959268 8.40210501034588e-13 -1.82386828224005 0.000371643290248406 miRNATAP -0.171102026127446 0.00506808000233376 NA NA NA hsa-miR-21-3p IPCEF1 3.50297439576639 6.39946844099206e-10 -0.785750192736651 0.297899854406347 MirTarget -0.258284866000011 0.000423336187971955 NA NA NA hsa-miR-106b-5p IRF9 2.80565545918114 1.14547999022566e-09 0.80913160702855 0.0753057419076235 miRNAWalker2_validate -0.13196586800048 0.0162175498771098 NA NA NA hsa-miR-15b-5p ISLR 3.32329949959268 8.40210501034588e-13 -3.99979216421173 5.69938231113032e-05 MirTarget;miRNATAP -0.594375982201149 4.00070769332686e-07 NA NA NA hsa-miR-106b-5p ISM1 2.80565545918114 1.14547999022566e-09 0.00591395068092981 0.995215111634877 miRNATAP -0.5486444737223 3.00310355569704e-06 NA NA NA hsa-miR-15b-5p ITGA10 3.32329949959268 8.40210501034588e-13 -3.0324799051313 0.000349758806116683 MirTarget -0.266817813729584 0.0084426851584161 NA NA NA hsa-miR-15b-5p ITPR1 3.32329949959268 8.40210501034588e-13 -3.70425443506097 1.11561643309084e-08 MirTarget;miRNATAP -0.360209089741216 3.58064306177447e-06 NA NA NA hsa-miR-15b-3p IYD 3.57530146629867 5.89922785773482e-11 1.16726165634079 0.492839179516911 mirMAP -0.42066069671597 0.0144126695959198 NA NA NA hsa-miR-106b-5p JAK1 2.80565545918114 1.14547999022566e-09 -0.607027067000509 0.0409054602478455 miRNAWalker2_validate;MirTarget -0.175735146885168 5.72236425533004e-07 NA NA NA hsa-miR-15b-5p JAK1 3.32329949959268 8.40210501034588e-13 -0.607027067000509 0.0409054602478455 miRNAWalker2_validate -0.128316156661929 0.000225441178274573 NA NA NA hsa-miR-106b-5p JAM3 2.80565545918114 1.14547999022566e-09 -4.55716845196292 3.17924787571565e-15 mirMAP -0.52618175152572 7.29157217994588e-14 NA NA NA hsa-miR-106b-5p JAZF1 2.80565545918114 1.14547999022566e-09 -3.33129870532741 1.36253596046008e-08 MirTarget;miRNATAP -0.225075836476325 0.00186232699934903 NA NA NA hsa-miR-21-3p JMY 3.50297439576639 6.39946844099206e-10 -1.16992277613374 0.00211866453801225 mirMAP -0.185101802908978 4.52185356412885e-07 NA NA NA hsa-miR-21-5p JMY 2.65163477806992 6.72089787690756e-16 -1.16992277613374 0.00211866453801225 miRNAWalker2_validate;mirMAP -0.173881067481526 0.00663814163868082 NA NA NA hsa-miR-21-5p JPH1 2.65163477806992 6.72089787690756e-16 0.528501083765315 0.56216701409336 miRNAWalker2_validate;miRNATAP -0.38898954315518 0.0110083951623247 NA NA NA hsa-miR-15b-5p KALRN 3.32329949959268 8.40210501034588e-13 -2.55318656096969 0.00763454392675142 miRNATAP -0.497907512878256 9.87797616703048e-06 NA NA NA hsa-miR-106b-5p KANK1 2.80565545918114 1.14547999022566e-09 -1.88289008892227 0.00218127163945131 mirMAP -0.299799709453573 5.08012256008162e-05 NA NA NA hsa-miR-15b-3p KANK1 3.57530146629867 5.89922785773482e-11 -1.88289008892227 0.00218127163945131 mirMAP -0.316770545420911 2.46168851598019e-07 NA NA NA hsa-miR-106b-5p KANK2 2.80565545918114 1.14547999022566e-09 -3.73434118557143 3.92460796375949e-15 miRNAWalker2_validate;mirMAP -0.359827577694412 8.18764967576605e-10 NA NA NA hsa-miR-106b-5p KAT2B 2.80565545918114 1.14547999022566e-09 -1.07154210738308 0.0359102937350788 miRNAWalker2_validate;miRTarBase;MirTarget -0.275926867148753 6.1000129405317e-06 NA NA NA hsa-miR-106b-5p KATNAL1 2.80565545918114 1.14547999022566e-09 -1.62922362530826 0.00106670038821508 miRNAWalker2_validate;MirTarget -0.187921422927813 0.00182633005903143 NA NA NA hsa-miR-21-5p KBTBD6 2.65163477806992 6.72089787690756e-16 -0.515350676377174 0.145697180002636 miRNAWalker2_validate;MirTarget -0.190319451135947 0.00127013266829421 NA NA NA hsa-miR-15b-5p KCNA6 3.32329949959268 8.40210501034588e-13 -2.63328552000616 0.0198576857959134 MirTarget -0.558548928035879 2.7273128564129e-05 NA NA NA hsa-miR-15b-5p KCNAB1 3.32329949959268 8.40210501034588e-13 -3.14459670125505 8.11637750019704e-08 MirTarget;miRNATAP -0.146832513269661 0.0386350686895915 NA NA NA hsa-miR-106b-5p KCND3 2.80565545918114 1.14547999022566e-09 -1.60315643295605 0.248612711096669 mirMAP -0.816819641570916 7.89055787960865e-07 NA NA NA hsa-miR-106b-5p KCNE4 2.80565545918114 1.14547999022566e-09 -4.83910948018355 3.7708355761718e-08 miRNATAP -0.541405487153946 4.21462142225294e-07 NA NA NA hsa-miR-21-5p KCNK3 2.65163477806992 6.72089787690756e-16 -3.97793301665669 0.00115285553598102 mirMAP -0.449368677776262 0.0302956580318717 NA NA NA hsa-miR-106b-5p KCNMA1 2.80565545918114 1.14547999022566e-09 -6.35220438452478 7.36900019441017e-10 miRNATAP -0.703529192552177 2.1920237717933e-08 NA NA NA hsa-miR-21-3p KCNMA1 3.50297439576639 6.39946844099206e-10 -6.35220438452478 7.36900019441017e-10 MirTarget -0.541081378637279 1.09270989130188e-07 NA NA NA hsa-miR-15b-5p KDR 3.32329949959268 8.40210501034588e-13 -3.78753480302955 5.10405108636238e-08 miRNATAP -0.444129453078938 7.74379928112357e-08 NA NA NA hsa-miR-106b-5p KDSR 2.80565545918114 1.14547999022566e-09 -0.722022255778804 0.0332963812692346 mirMAP -0.102193499977431 0.0123669898791772 NA NA NA hsa-miR-106b-5p KIAA0355 2.80565545918114 1.14547999022566e-09 -1.30124348911086 0.000105005996772825 mirMAP -0.117792620287422 0.00378036291574506 NA NA NA hsa-miR-21-3p KIAA0430 3.50297439576639 6.39946844099206e-10 -0.663457860690293 0.00811882076460608 MirTarget -0.129919791251099 5.27542568804359e-08 NA NA NA hsa-miR-106b-5p KIAA0513 2.80565545918114 1.14547999022566e-09 -0.307391454307007 0.603709752902539 MirTarget;miRNATAP -0.221040154022035 0.00189588162698866 NA NA NA hsa-miR-15b-3p KIAA0513 3.57530146629867 5.89922785773482e-11 -0.307391454307007 0.603709752902539 mirMAP -0.161411065379586 0.00680010153012668 NA NA NA hsa-miR-15b-5p KIAA0513 3.32329949959268 8.40210501034588e-13 -0.307391454307007 0.603709752902539 mirMAP -0.173006431192379 0.0134473790923347 NA NA NA hsa-miR-21-3p KIAA1211 3.50297439576639 6.39946844099206e-10 -2.12153302686681 0.0431423992641562 MirTarget -0.573780511836712 1.13074399840329e-08 NA NA NA hsa-miR-21-3p KIAA1462 3.50297439576639 6.39946844099206e-10 -4.21843344330322 1.46499915072858e-09 MirTarget -0.358577170367289 1.88903829780652e-07 NA NA NA hsa-miR-15b-5p KIAA1644 3.32329949959268 8.40210501034588e-13 -5.72791566907951 3.3324526907743e-07 mirMAP -0.757145826447002 1.17913673100132e-08 NA NA NA hsa-miR-15b-3p KIDINS220 3.57530146629867 5.89922785773482e-11 -0.680683096963149 0.0818083298664093 MirTarget -0.112240050262002 0.00434209284860186 NA NA NA hsa-miR-30a-5p KIF11 -0.768430903969183 0.320487552854215 4.8787830060231 1.98491188162129e-32 miRNAWalker2_validate;MirTarget -0.116349253328316 0.00049641314521609 NA NA NA hsa-miR-381-3p KIF11 -1.89657986656844 0.00522802447631986 4.8787830060231 1.98491188162129e-32 MirTarget -0.105230299739428 0.00566744937239881 NA NA NA hsa-miR-15b-5p KIF13B 3.32329949959268 8.40210501034588e-13 -0.290431626701987 0.630391308580382 mirMAP -0.189477910049836 0.00786367925179699 NA NA NA hsa-miR-15b-5p KIF1C 3.32329949959268 8.40210501034588e-13 -0.362919810974169 0.302050090389453 miRNATAP -0.150409084442428 0.000261318007283971 NA NA NA hsa-miR-129-5p KIF20A -2.66843722411409 0.00695783358331245 6.75064385414619 1.50393371231116e-37 miRanda -0.110961555519132 0.00129044674415741 NA NA NA hsa-miR-140-5p KIF20A -0.634610285725923 0.126670572966239 6.75064385414619 1.50393371231116e-37 miRanda -0.167150616304221 0.0433122871974616 NA NA NA hsa-miR-125a-5p KIF23 -1.32352790615388 0.00714301627309467 3.87048384190928 2.20232678193672e-21 miRanda -0.133352733481977 0.00815862623638879 NA NA NA hsa-miR-101-3p KIF2C -1.12421603598195 0.0200907284788457 5.27858050978094 8.36455746009661e-42 miRNAWalker2_validate -0.135590927120878 0.0101016329087681 NA NA NA hsa-miR-15b-5p KIF5A 3.32329949959268 8.40210501034588e-13 -2.87476415181423 0.0126478048111447 MirTarget;miRNATAP -0.552063005743027 4.90661351644694e-05 NA NA NA hsa-miR-21-3p KIF5C 3.50297439576639 6.39946844099206e-10 -1.16890553485052 0.190756709896642 mirMAP -0.339689443849866 8.74408857168485e-05 NA NA NA hsa-miR-21-3p KIRREL3 3.50297439576639 6.39946844099206e-10 -2.68202759618687 0.0176276214665417 MirTarget -0.22440514896834 0.0430578402511557 NA NA NA hsa-miR-15b-5p KLF6 3.32329949959268 8.40210501034588e-13 -0.875845028436705 0.120819285626917 mirMAP -0.160825597830284 0.0161395280846849 NA NA NA hsa-miR-106b-5p KLF9 2.80565545918114 1.14547999022566e-09 -3.69570385779272 1.71840900056727e-08 MirTarget;miRNATAP -0.388975618796866 1.12973798504961e-06 NA NA NA hsa-miR-21-5p KLF9 2.65163477806992 6.72089787690756e-16 -3.69570385779272 1.71840900056727e-08 miRNAWalker2_validate -0.32916604287343 0.00344377617703506 NA NA NA hsa-miR-15b-5p KLHDC8B 3.32329949959268 8.40210501034588e-13 -1.16805081782235 0.0458748569415414 MirTarget -0.236092044653493 0.000627178364735806 NA NA NA hsa-miR-15b-3p KLHL14 3.57530146629867 5.89922785773482e-11 -4.34534927912236 0.0247921917450246 miRNATAP -0.706421300825073 0.000294670144756656 NA NA NA hsa-miR-21-5p KLHL15 2.65163477806992 6.72089787690756e-16 -1.04585843267989 0.0017471745764228 miRNAWalker2_validate;miRNATAP -0.188499067386183 0.00075853693323871 NA NA NA hsa-miR-106b-5p KLHL20 2.80565545918114 1.14547999022566e-09 -0.289138336963628 0.433624923852354 MirTarget;miRNATAP -0.105331483961839 0.017661331741647 NA NA NA hsa-miR-106b-5p KLHL28 2.80565545918114 1.14547999022566e-09 -0.128869753705134 0.761151352500069 miRNATAP -0.119880411349709 0.0187769264798329 NA NA NA hsa-miR-106b-5p KLHL3 2.80565545918114 1.14547999022566e-09 -2.04135558829045 0.00444293805485006 mirMAP -0.180814729355907 0.0381426421819475 NA NA NA hsa-miR-106b-5p KLHL6 2.80565545918114 1.14547999022566e-09 0.986293732647768 0.19763061639081 mirMAP -0.210186903293353 0.0230847712444176 NA NA NA hsa-miR-15b-5p KY 3.32329949959268 8.40210501034588e-13 -4.51730039740277 0.000161855374668056 MirTarget -0.288202895528415 0.0447618770732763 NA NA NA hsa-miR-21-5p LAMA4 2.65163477806992 6.72089787690756e-16 -3.56149879705325 1.27923401133307e-06 MirTarget -0.341718185439046 0.00650238283200569 NA NA NA hsa-miR-21-5p LANCL1 2.65163477806992 6.72089787690756e-16 -0.754023109644352 0.0440716620238008 MirTarget -0.286316946299104 3.90718900764743e-06 NA NA NA hsa-miR-106b-5p LAT2 2.80565545918114 1.14547999022566e-09 0.477705192936754 0.424550320596697 mirMAP -0.20956617343275 0.00359763721747416 NA NA NA hsa-miR-15b-5p LATS2 3.32329949959268 8.40210501034588e-13 -1.64065240798514 0.000675576860801643 miRNATAP -0.202584110889233 0.000399028596231128 NA NA NA hsa-miR-106b-5p LDB3 2.80565545918114 1.14547999022566e-09 -4.98298456949931 5.31105921265114e-08 mirMAP -0.400326752131782 0.000375179394987726 NA NA NA hsa-miR-21-5p LGI2 2.65163477806992 6.72089787690756e-16 -5.12012833009034 3.21508342393231e-05 mirMAP -1.0505624507923 3.53309800627791e-07 NA NA NA hsa-miR-21-5p LIFR 2.65163477806992 6.72089787690756e-16 -4.50998571221338 7.2608759563341e-06 miRNAWalker2_validate -0.413069428741514 0.0160360423597388 NA NA NA hsa-miR-15b-3p LIN7A 3.57530146629867 5.89922785773482e-11 -4.65222042649615 5.12906307328624e-05 mirMAP -0.359618651535575 0.00214818379823233 NA NA NA hsa-miR-21-5p LMBR1 2.65163477806992 6.72089787690756e-16 -0.376146480633174 0.297072157807507 miRNAWalker2_validate -0.199353370356051 0.000905088016829187 NA NA NA hsa-miR-106b-5p LMO3 2.80565545918114 1.14547999022566e-09 -6.71985759868977 2.94970568387463e-05 MirTarget;miRNATAP -1.12083776963185 5.84363282782516e-09 NA NA NA hsa-miR-15b-3p LMTK2 3.57530146629867 5.89922785773482e-11 1.30410334714678 0.0857255607321283 miRNATAP -0.156495189811841 0.0417203350701684 NA NA NA hsa-miR-21-3p LMTK2 3.50297439576639 6.39946844099206e-10 1.30410334714678 0.0857255607321283 mirMAP -0.15565946575161 0.0360721323173395 NA NA NA hsa-miR-15b-3p LONRF2 3.57530146629867 5.89922785773482e-11 -7.74009225781095 4.99123310413264e-06 mirMAP -0.758631939357265 1.05655504971221e-05 NA NA NA hsa-miR-21-3p LONRF2 3.50297439576639 6.39946844099206e-10 -7.74009225781095 4.99123310413264e-06 mirMAP -0.834964946745615 4.62944205532168e-07 NA NA NA hsa-miR-21-5p LONRF2 2.65163477806992 6.72089787690756e-16 -7.74009225781095 4.99123310413264e-06 miRNAWalker2_validate -1.0336047631362 0.000330579359853144 NA NA NA hsa-let-7e-5p LOR -0.111012524740586 0.814744515884005 1.54018359510849 0.249509496267185 MirTarget -0.64113262184971 6.53511450725639e-05 NA NA NA hsa-miR-30b-3p LOR 0.169674321578618 0.766080356926625 1.54018359510849 0.249509496267185 MirTarget;miRNATAP -0.43428199382749 0.00119662547404268 NA NA NA hsa-miR-106b-5p LRFN5 2.80565545918114 1.14547999022566e-09 -4.63910566256184 0.000144828400416712 miRNATAP -0.958416893208203 3.38597857535304e-11 NA NA NA hsa-miR-15b-3p LRP10 3.57530146629867 5.89922785773482e-11 -0.844979977715282 0.0178141804407255 mirMAP -0.14088720850624 7.95635972587809e-05 NA NA NA hsa-miR-15b-3p LRP6 3.57530146629867 5.89922785773482e-11 -1.5108432620961 0.00142291856207554 mirMAP -0.126415824983402 0.0085095996610987 NA NA NA hsa-miR-15b-3p LRRC15 3.57530146629867 5.89922785773482e-11 -0.286008638098385 0.83843609864784 mirMAP -0.278277774923198 0.0498212744937113 NA NA NA hsa-miR-21-3p LRRC27 3.50297439576639 6.39946844099206e-10 -1.21748158993514 0.0205793210174614 mirMAP -0.176770502220806 0.000550804525373129 NA NA NA hsa-miR-15b-5p LRRK1 3.32329949959268 8.40210501034588e-13 -0.534162563079435 0.437947352319972 MirTarget -0.305636151517639 0.00015879895785246 NA NA NA hsa-miR-15b-5p LRRN3 3.32329949959268 8.40210501034588e-13 -0.713458734948297 0.447033507610619 MirTarget;miRNATAP -0.256604695056031 0.0209453722712363 NA NA NA hsa-miR-106b-5p LRRN4CL 2.80565545918114 1.14547999022566e-09 -5.99877574074961 7.73549359018349e-11 mirMAP -0.840376755201092 2.67866148469664e-14 NA NA NA hsa-miR-106b-5p LSAMP 2.80565545918114 1.14547999022566e-09 -3.10160747894937 0.00681000884985815 miRNATAP -0.636424591324108 3.62848192469271e-06 NA NA NA hsa-miR-21-5p LTV1 2.65163477806992 6.72089787690756e-16 0.0310572945531762 0.920472604121241 MirTarget -0.141981176406729 0.0061361303551934 NA NA NA hsa-miR-15b-5p LUZP1 3.32329949959268 8.40210501034588e-13 -0.297929875474872 0.49567065918059 MirTarget;miRNATAP -0.124523734132517 0.0158529341819429 NA NA NA hsa-miR-21-5p LYRM7 2.65163477806992 6.72089787690756e-16 -0.483582249385659 0.1500972231869 miRNAWalker2_validate -0.173802036993536 0.00191866220096535 NA NA NA hsa-miR-21-5p LZTFL1 2.65163477806992 6.72089787690756e-16 -0.837480628888104 0.0698898733803269 MirTarget -0.179198101665297 0.0209271424566733 NA NA NA hsa-miR-139-5p MAD2L1 -2.09475477693654 0.000382570602748311 3.3383580403537 1.18308271249632e-16 miRanda -0.101952484259931 0.0119362559491124 NA NA NA hsa-miR-106b-5p MAF 2.80565545918114 1.14547999022566e-09 -1.67642643216486 0.0648843975805926 mirMAP -0.298942014871778 0.00644212429152172 NA NA NA hsa-miR-21-3p MAGEL2 3.50297439576639 6.39946844099206e-10 -4.93948228566689 6.27026624135822e-06 MirTarget -0.703562563324355 2.17838586450765e-11 NA NA NA hsa-miR-106b-5p MAGI3 2.80565545918114 1.14547999022566e-09 0.304848308849507 0.554623394921288 MirTarget -0.18307256704567 0.00315604412013857 NA NA NA hsa-miR-15b-3p MAN1A1 3.57530146629867 5.89922785773482e-11 -1.50591991272115 0.0977557179154708 MirTarget;miRNATAP -0.420023038539946 3.76771700966321e-06 NA NA NA hsa-miR-15b-3p MAP1B 3.57530146629867 5.89922785773482e-11 -3.21089551833294 0.00228958674577565 mirMAP -0.21395134126058 0.046034209410539 NA NA NA hsa-miR-106b-5p MAP3K1 2.80565545918114 1.14547999022566e-09 0.634215972142603 0.181579485320679 miRNATAP -0.114127742480193 0.0464819422095244 NA NA NA hsa-miR-106b-5p MAP3K12 2.80565545918114 1.14547999022566e-09 -2.51383227649074 1.30414732983547e-05 MirTarget -0.198173484574605 0.00490609967217734 NA NA NA hsa-miR-106b-5p MAP3K14 2.80565545918114 1.14547999022566e-09 -0.572095255643433 0.232052277296526 MirTarget -0.147103803660124 0.0107438423053429 NA NA NA hsa-miR-106b-5p MAP3K3 2.80565545918114 1.14547999022566e-09 -1.60402819876079 1.58145535314045e-06 MirTarget;miRNATAP -0.164478465228658 4.89480997327766e-05 NA NA NA hsa-miR-15b-5p MAP3K3 3.32329949959268 8.40210501034588e-13 -1.60402819876079 1.58145535314045e-06 MirTarget;miRNATAP -0.129645780076453 0.00116299034930129 NA NA NA hsa-miR-106b-5p MAP3K5 2.80565545918114 1.14547999022566e-09 0.451793768919489 0.393484533177232 miRNATAP -0.144489588307781 0.0236418224520258 NA NA NA hsa-miR-106b-5p MAP9 2.80565545918114 1.14547999022566e-09 -3.48310470700611 0.00584984395739744 miRNATAP -0.331334193640594 0.0310292455529103 NA NA NA hsa-miR-106b-5p MAPRE2 2.80565545918114 1.14547999022566e-09 -1.36546252635453 0.024793998993571 mirMAP -0.200274296665651 0.00645357886831811 NA NA NA hsa-miR-15b-3p MARCH8 3.57530146629867 5.89922785773482e-11 -0.89580428142125 0.185515939584244 mirMAP -0.173504670594176 0.0110773979743815 NA NA NA hsa-miR-15b-5p MASP1 3.32329949959268 8.40210501034588e-13 -7.30332253078637 3.70921888514746e-08 MirTarget -0.783672423025908 7.70378997786153e-07 NA NA NA hsa-miR-21-5p MATN2 2.65163477806992 6.72089787690756e-16 -4.0786586351949 1.28807808428616e-07 miRNATAP -0.373490041239193 0.00476066152834163 NA NA NA hsa-miR-21-5p MATR3 2.65163477806992 6.72089787690756e-16 -0.494114728073118 0.0126983645766475 miRNATAP -0.119782104744179 0.000247503162539096 NA NA NA hsa-miR-15b-5p MBNL2 3.32329949959268 8.40210501034588e-13 -1.12233809482155 0.0459066411907178 MirTarget -0.211183183122816 0.00147600983793211 NA NA NA hsa-miR-21-3p MBNL3 3.50297439576639 6.39946844099206e-10 1.25666817711992 0.129657716983562 MirTarget -0.162781021565741 0.0448362034335029 NA NA NA hsa-miR-106b-5p MBOAT2 2.80565545918114 1.14547999022566e-09 1.16994587565343 0.0929695263399865 mirMAP -0.209024004173774 0.0129891281070112 NA NA NA hsa-miR-106b-5p MCC 2.80565545918114 1.14547999022566e-09 -0.677048767626195 0.467768009277233 MirTarget -0.256082562586505 0.0229667042494665 NA NA NA hsa-miR-106b-5p MCL1 2.80565545918114 1.14547999022566e-09 0.141019406304951 0.704491791982446 MirTarget;miRNATAP -0.135613391231181 0.0023369579481254 NA NA NA hsa-miR-199a-5p MCM10 -1.24888110793613 0.0747755616523728 6.99458068332381 2.17917381302409e-47 miRanda -0.142591902343834 0.00180334326094087 NA NA NA hsa-miR-199b-5p MCM10 -0.53728867775768 0.476885702455766 6.99458068332381 2.17917381302409e-47 miRanda -0.135909122761699 0.00136018223043806 NA NA NA hsa-miR-140-5p MCM4 -0.634610285725923 0.126670572966239 4.07456708888893 1.18347519121226e-20 MirTarget -0.179614469050476 0.00532928598284261 NA NA NA hsa-miR-15b-3p MDM4 3.57530146629867 5.89922785773482e-11 0.0211961799945204 0.95100073912392 mirMAP -0.16053518422057 2.65460975112255e-06 NA NA NA hsa-miR-21-3p MDM4 3.50297439576639 6.39946844099206e-10 0.0211961799945204 0.95100073912392 MirTarget -0.173114587075356 1.41406030577636e-07 NA NA NA hsa-miR-21-3p MECP2 3.50297439576639 6.39946844099206e-10 -0.959201764409396 0.0008812070498292 mirMAP -0.110504527031797 7.70198270904475e-05 NA NA NA hsa-miR-21-5p MECP2 2.65163477806992 6.72089787690756e-16 -0.959201764409396 0.0008812070498292 mirMAP -0.103092059482615 0.0336538785226441 NA NA NA hsa-miR-21-5p MED28 2.65163477806992 6.72089787690756e-16 -0.507050798408387 0.0887796771543679 MirTarget -0.20040368353845 4.88355788017623e-05 NA NA NA hsa-miR-21-5p MEF2C 2.65163477806992 6.72089787690756e-16 -3.76925742594602 1.08516088119004e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.225683820978908 0.0348242516324477 NA NA NA hsa-miR-106b-5p MEF2D 2.80565545918114 1.14547999022566e-09 -1.60022304030769 2.0684160611841e-07 mirMAP -0.10756601293868 0.00431718111899217 NA NA NA hsa-miR-181c-5p MELK -0.302833440762172 0.537532549455539 7.06668502616739 5.44301365455911e-49 MirTarget -0.191683192563866 0.00355029598257069 NA NA NA hsa-miR-181d-5p MELK -0.529098579553155 0.325262124523294 7.06668502616739 5.44301365455911e-49 MirTarget -0.175106282783865 0.00344829048264356 NA NA NA hsa-miR-15b-5p MEOX2 3.32329949959268 8.40210501034588e-13 -6.18911690837205 8.25312647316889e-08 MirTarget -0.87523732036139 1.18489821604431e-10 NA NA NA hsa-miR-106b-3p MEX3B 2.57689304590494 1.04870442173494e-07 -1.907958105692 0.0200623303361945 mirMAP -0.24073566980037 0.0113243859522719 NA NA NA hsa-miR-106b-5p MEX3B 2.80565545918114 1.14547999022566e-09 -1.907958105692 0.0200623303361945 mirMAP -0.231706179506666 0.0198159686741926 NA NA NA hsa-miR-15b-3p MFAP5 3.57530146629867 5.89922785773482e-11 -6.02112429395012 0.00031991851708567 MirTarget -0.542458835094591 0.00143097654818331 NA NA NA hsa-miR-15b-5p MFAP5 3.32329949959268 8.40210501034588e-13 -6.02112429395012 0.00031991851708567 MirTarget -0.917022483968632 3.49510777724524e-06 NA NA NA hsa-miR-21-3p MIA3 3.50297439576639 6.39946844099206e-10 -0.0506329867954367 0.861441568825815 MirTarget -0.103931901582456 0.000195625907533385 NA NA NA hsa-miR-21-5p MIB1 2.65163477806992 6.72089787690756e-16 -0.578766598664993 0.12174762843238 miRNAWalker2_validate;mirMAP -0.145038818945233 0.0206323249775761 NA NA NA hsa-miR-15b-5p MICALL1 3.32329949959268 8.40210501034588e-13 0.733539722343899 0.272087780339599 mirMAP -0.166478428122537 0.035427662363896 NA NA NA hsa-miR-15b-5p MKX 3.32329949959268 8.40210501034588e-13 -1.60951154749949 0.197380908088214 MirTarget -0.364949435541652 0.0136527288734976 NA NA NA hsa-miR-361-5p MMP1 0.00649167180664723 0.985202350239079 5.12402869798523 0.00281884054751446 miRanda -0.714759915397073 0.0125335615288654 NA NA NA hsa-miR-145-5p MMP12 -3.55505374822025 5.45525288912869e-07 4.86908154659711 0.000376456452568158 miRNAWalker2_validate -0.41916752330102 0.000100309427458533 NA NA NA hsa-miR-21-3p MMP16 3.50297439576639 6.39946844099206e-10 -2.72149028413419 0.00811088250623818 mirMAP -0.347846205367336 0.000527774545793863 NA NA NA hsa-miR-21-3p MMRN2 3.50297439576639 6.39946844099206e-10 -3.64157013517831 2.07814595195503e-10 MirTarget -0.29809486112447 1.42585741889602e-07 NA NA NA hsa-miR-21-5p MOAP1 2.65163477806992 6.72089787690756e-16 -1.50808840274716 0.000202976313252946 miRNAWalker2_validate -0.280926324758217 3.65074948937291e-05 NA NA NA hsa-miR-21-5p MOXD1 2.65163477806992 6.72089787690756e-16 -4.24750172047872 0.000476218425097882 miRNAWalker2_validate -0.73716547063514 0.000322386951962628 NA NA NA hsa-miR-15b-5p MPP1 3.32329949959268 8.40210501034588e-13 -1.58808260656771 0.0274812369785901 miRNAWalker2_validate -0.366744808600644 1.47141068880266e-05 NA NA NA hsa-miR-106b-5p MPPED2 2.80565545918114 1.14547999022566e-09 -2.44778615133919 0.158232723608989 mirMAP -0.861660751154955 3.38800371779621e-05 NA NA NA hsa-miR-21-5p MPRIP 2.65163477806992 6.72089787690756e-16 -1.56361211612266 5.52507002193216e-05 miRNATAP -0.166394294824773 0.0112857412943285 NA NA NA hsa-miR-106b-5p MR1 2.80565545918114 1.14547999022566e-09 0.683140161506681 0.232381520940423 mirMAP -0.168653793323512 0.0145163579014398 NA NA NA hsa-miR-106b-5p MSRB3 2.80565545918114 1.14547999022566e-09 -5.12134814852364 2.69870314210263e-08 mirMAP -0.618510509025407 3.05045566096555e-08 NA NA NA hsa-miR-21-5p MSX1 2.65163477806992 6.72089787690756e-16 -4.19642959068543 3.24025433167506e-05 miRNATAP -0.902353703588755 8.92992381193181e-08 NA NA NA hsa-miR-15b-5p MTHFR 3.32329949959268 8.40210501034588e-13 -0.491000290352801 0.260617556851782 MirTarget -0.174844702363003 0.000656247943315948 NA NA NA hsa-miR-21-5p MTMR12 2.65163477806992 6.72089787690756e-16 -0.708332661419828 0.102376681951115 miRNAWalker2_validate;miRNATAP -0.179000951856344 0.0138358199246457 NA NA NA hsa-miR-15b-5p MTMR6 3.32329949959268 8.40210501034588e-13 -0.843607472461996 0.0150445967798917 miRNAWalker2_validate -0.131185600630595 0.00134139509066131 NA NA NA hsa-miR-21-5p MTR 2.65163477806992 6.72089787690756e-16 -0.748955778408294 0.0204590987804726 mirMAP -0.122508649705693 0.0237737221389735 NA NA NA hsa-miR-106b-5p MUC20 2.80565545918114 1.14547999022566e-09 1.73357376272074 0.20487579905627 mirMAP -0.477409506268415 0.00379682490831023 NA NA NA hsa-miR-15b-3p MUC20 3.57530146629867 5.89922785773482e-11 1.73357376272074 0.20487579905627 mirMAP -0.281246953694697 0.0421987007782788 NA NA NA hsa-miR-21-3p MUM1L1 3.50297439576639 6.39946844099206e-10 -4.76929869076722 0.000330482507765304 MirTarget -0.421303410179568 0.00124518963769883 NA NA NA hsa-let-7d-5p MXD1 0.831142050231414 0.0126955498524287 1.61228875419633 0.0399212117540836 MirTarget;miRNATAP -0.336438662354436 0.0136899313509445 NA NA NA hsa-let-7e-5p MXD1 -0.111012524740586 0.814744515884005 1.61228875419633 0.0399212117540836 MirTarget;miRNATAP -0.587559013302685 2.16146605256358e-10 NA NA NA hsa-miR-106a-5p MXD1 3.98693608217557 9.37722470816656e-07 1.61228875419633 0.0399212117540836 mirMAP -0.229219168148047 1.72162877805808e-05 NA NA NA hsa-miR-125a-3p MXD1 -0.0748960586927341 0.920735897434087 1.61228875419633 0.0399212117540836 miRanda -0.292753051081321 5.74949751768062e-07 NA NA NA hsa-miR-148b-3p MXD1 1.75622244535669 8.84414356040579e-08 1.61228875419633 0.0399212117540836 MirTarget -0.28665741324465 0.0355142816068389 NA NA NA hsa-miR-195-3p MXD1 -2.39100534119332 0.000185405399054065 1.61228875419633 0.0399212117540836 mirMAP -0.234847533007847 0.000709931159308939 NA NA NA hsa-miR-200b-3p MXD1 5.56167217794639 6.43540045061709e-16 1.61228875419633 0.0399212117540836 mirMAP -0.225133419041334 0.00024161177171269 NA NA NA hsa-miR-20b-5p MXD1 4.5662923200279 4.75238200639144e-05 1.61228875419633 0.0399212117540836 mirMAP -0.156270423524479 5.72268346246448e-05 NA NA NA hsa-miR-217 MXD1 -0.378397407994341 0.717408682071252 1.61228875419633 0.0399212117540836 miRanda -0.123018088912916 0.00406671421184712 NA NA NA hsa-miR-30a-3p MXD1 -1.22212086897848 0.167565797592104 1.61228875419633 0.0399212117540836 mirMAP -0.35105040443082 4.35276734668279e-13 NA NA NA hsa-miR-30d-3p MXD1 -0.0740421896025512 0.857423650167556 1.61228875419633 0.0399212117540836 mirMAP -0.35309014445706 0.00125977336443334 NA NA NA hsa-miR-324-3p MXD1 1.51345381556672 0.0038447546677657 1.61228875419633 0.0399212117540836 MirTarget -0.320643963711192 0.000153442631075482 NA NA NA hsa-miR-335-5p MXD1 0.167216045757305 0.803897055331049 1.61228875419633 0.0399212117540836 miRNAWalker2_validate -0.397014339508919 8.8308001865367e-10 NA NA NA hsa-miR-3607-3p MXD1 1.38015131722213 0.0240067155694847 1.61228875419633 0.0399212117540836 mirMAP -0.210018523755284 0.00393919450511279 NA NA NA hsa-miR-3913-5p MXD1 0.145645056779437 0.734844256690741 1.61228875419633 0.0399212117540836 MirTarget -0.51005058884168 8.49688813383835e-07 NA NA NA hsa-miR-429 MXD1 6.39965293994036 1.96920201593608e-18 1.61228875419633 0.0399212117540836 mirMAP;miRNATAP -0.194535507566245 0.000687820842876837 NA NA NA hsa-miR-501-5p MXD1 1.0411896821345 0.0777206709183552 1.61228875419633 0.0399212117540836 mirMAP -0.193222342521487 0.0107511304427224 NA NA NA hsa-miR-508-3p MXD1 0.975099105064348 0.439528954969797 1.61228875419633 0.0399212117540836 miRNATAP -0.156505928939629 9.22114429949626e-06 NA NA NA hsa-miR-589-3p MXD1 1.33205316880069 0.052632683806148 1.61228875419633 0.0399212117540836 MirTarget -0.199268870961985 0.00221741353795596 NA NA NA hsa-miR-592 MXD1 2.80403350008555 0.0293520213681333 1.61228875419633 0.0399212117540836 mirMAP -0.225300480879779 6.3651532011192e-08 NA NA NA hsa-miR-625-5p MXD1 2.02792641909347 0.000935142379948297 1.61228875419633 0.0399212117540836 MirTarget -0.252665577603571 0.000511414544442067 NA NA NA hsa-miR-15b-5p MXD4 3.32329949959268 8.40210501034588e-13 -1.39016053188047 0.000613508373506407 mirMAP -0.103945526878541 0.0316257154133946 NA NA NA hsa-miR-15b-5p MYCBP2 3.32329949959268 8.40210501034588e-13 -0.110073533970725 0.834275633697262 miRNAWalker2_validate -0.194496367878017 0.00169234325944392 NA NA NA hsa-miR-21-5p MYEF2 2.65163477806992 6.72089787690756e-16 -3.12364610498451 0.0244571993324016 miRNAWalker2_validate -0.933323926355948 5.80592326962164e-05 NA NA NA hsa-miR-15b-5p MYLK 3.32329949959268 8.40210501034588e-13 -5.73620551906387 2.04578586058996e-10 MirTarget;miRNATAP -0.668563659466959 4.80371439869088e-10 NA NA NA hsa-miR-106b-5p MYO1D 2.80565545918114 1.14547999022566e-09 0.570739747697879 0.197126012253067 miRNATAP -0.123527831616557 0.0205633733770192 NA NA NA hsa-miR-106b-5p MYO5A 2.80565545918114 1.14547999022566e-09 -0.133030035892503 0.844074517488657 mirMAP -0.2651684243945 0.00109756675497822 NA NA NA hsa-miR-15b-5p MYO5A 3.32329949959268 8.40210501034588e-13 -0.133030035892503 0.844074517488657 MirTarget -0.211227912179662 0.00820836731248779 NA NA NA hsa-miR-15b-5p MYRIP 3.32329949959268 8.40210501034588e-13 -5.94811425896938 1.26857704126111e-05 MirTarget -0.417869755612615 0.0106973599123653 NA NA NA hsa-miR-15b-3p MYSM1 3.57530146629867 5.89922785773482e-11 1.11136415502036 0.0941265836143903 mirMAP -0.158615296219181 0.0181177701909103 NA NA NA hsa-miR-15b-5p N4BP1 3.32329949959268 8.40210501034588e-13 0.49508890443648 0.205063675151664 miRNATAP -0.116426021514165 0.0115502684568363 NA NA NA hsa-miR-15b-3p NALCN 3.57530146629867 5.89922785773482e-11 -2.96900446210743 0.0245973927525346 MirTarget -0.500397881589216 0.000168610589028529 NA NA NA hsa-miR-21-3p NAP1L5 3.50297439576639 6.39946844099206e-10 -2.41159783659587 0.00106634000924495 MirTarget -0.211192904641823 0.00349620884969783 NA NA NA hsa-miR-15b-3p NAV2 3.57530146629867 5.89922785773482e-11 0.385207596322868 0.611030537021824 MirTarget -0.150492655520447 0.049299155204488 NA NA NA hsa-miR-21-3p NAV3 3.50297439576639 6.39946844099206e-10 -4.15438375372593 0.000608306049628081 MirTarget -0.521554600914938 9.98813802010549e-06 25579119 We identify NAV3 as a potential target of miR-21-3p and show that knockdown of NAV3 increases resistance; Finally we use publically available transcriptomic data to demonstrate that miR-21-3p is raised while NAV3 is reduced in ovarian tumours that are resistant to platinum treatment; Our data suggest that miR-21-3p can induce cisplatin resistance in ovarian tumours potentially by targeting the NAV3 gene drug resistance ovarian cancer hsa-miR-106b-5p NBEA 2.80565545918114 1.14547999022566e-09 -4.10952230064763 0.00318502554132168 MirTarget;miRNATAP -0.482120798255212 0.00434991654007601 NA NA NA hsa-miR-21-5p NBEA 2.65163477806992 6.72089787690756e-16 -4.10952230064763 0.00318502554132168 miRNAWalker2_validate;miRNATAP -0.554508453177541 0.0186360733671344 NA NA NA hsa-miR-106b-5p NBL1 2.80565545918114 1.14547999022566e-09 -1.67185286745597 0.000603668997487049 miRNATAP -0.259217247301163 9.6958404588575e-06 NA NA NA hsa-miR-21-3p NCAM1 3.50297439576639 6.39946844099206e-10 -7.27033620647047 1.60252013841234e-13 MirTarget -0.772798524071688 6.9512113773903e-16 NA NA NA hsa-miR-15b-3p NCAM2 3.57530146629867 5.89922785773482e-11 -3.07363483903603 0.0818009748992128 mirMAP -0.727841471477443 3.99909280944858e-05 NA NA NA hsa-miR-106b-5p NCOA3 2.80565545918114 1.14547999022566e-09 0.470680586092867 0.205833378938701 MirTarget;miRNATAP -0.110393452844123 0.0136319609368238 NA NA NA hsa-miR-148b-3p NDN 1.75622244535669 8.84414356040579e-08 -5.07390710235974 1.70787649675861e-10 miRNAWalker2_validate -0.645964814327788 4.10735547602275e-06 NA NA NA hsa-miR-200b-3p NDN 5.56167217794639 6.43540045061709e-16 -5.07390710235974 1.70787649675861e-10 MirTarget;TargetScan -0.348457940780557 3.30417797669987e-08 NA NA NA hsa-miR-200c-3p NDN 6.47012025883743 2.64500707716408e-26 -5.07390710235974 1.70787649675861e-10 MirTarget;miRNATAP -0.459194559205779 1.37577730641789e-11 NA NA NA hsa-miR-330-5p NDN 2.25110496739954 0.000275527655397415 -5.07390710235974 1.70787649675861e-10 miRanda -0.215861895067735 0.0037796267233179 NA NA NA hsa-miR-33a-3p NDN 2.06269680799532 0.00156436055383943 -5.07390710235974 1.70787649675861e-10 MirTarget -0.286118334740383 5.24174864783689e-05 NA NA NA hsa-miR-3607-3p NDN 1.38015131722213 0.0240067155694847 -5.07390710235974 1.70787649675861e-10 MirTarget -0.160023959496152 0.0357261517934042 NA NA NA hsa-miR-429 NDN 6.39965293994036 1.96920201593608e-18 -5.07390710235974 1.70787649675861e-10 MirTarget;PITA;miRanda;miRNATAP -0.329802613104109 2.04359015088967e-08 NA NA NA hsa-miR-486-5p NDN 1.10898145177457 0.309287974401609 -5.07390710235974 1.70787649675861e-10 miRanda -0.142151585238152 0.000794527138043051 NA NA NA hsa-miR-15b-3p NEGR1 3.57530146629867 5.89922785773482e-11 -5.44789313937809 2.41819782942133e-07 mirMAP;miRNATAP -0.491649863446474 4.78321613087894e-06 NA NA NA hsa-miR-21-5p NEK1 2.65163477806992 6.72089787690756e-16 -1.14036805779547 0.00420144753814483 miRNAWalker2_validate -0.24357941830864 0.000258355347524743 NA NA NA hsa-miR-21-3p NEK9 3.50297439576639 6.39946844099206e-10 -1.0163727215697 0.000362328868506925 MirTarget -0.102059755274385 0.000229244416695046 NA NA NA hsa-miR-106b-5p NFASC 2.80565545918114 1.14547999022566e-09 -2.43145916830151 0.0259317090720814 mirMAP -0.598320531929362 4.67478013357884e-06 NA NA NA hsa-miR-15b-5p NFASC 3.32329949959268 8.40210501034588e-13 -2.43145916830151 0.0259317090720814 MirTarget;mirMAP -0.344781927906316 0.0078077373283001 NA NA NA hsa-miR-15b-3p NFAT5 3.57530146629867 5.89922785773482e-11 -0.873812260090285 0.0142802458392285 mirMAP -0.126013171880713 0.000433697196258896 NA NA NA hsa-miR-21-3p NFAT5 3.50297439576639 6.39946844099206e-10 -0.873812260090285 0.0142802458392285 MirTarget -0.118527852125061 0.000620164790667205 NA NA NA hsa-miR-15b-3p NFATC4 3.57530146629867 5.89922785773482e-11 -3.51227827619475 3.3529829198664e-05 mirMAP -0.332671458598109 0.000109614721294728 NA NA NA hsa-miR-106b-5p NFIA 2.80565545918114 1.14547999022566e-09 -0.821609437910618 0.18121112770223 mirMAP -0.198093420594786 0.00750746716371134 NA NA NA hsa-miR-106b-5p NHLRC3 2.80565545918114 1.14547999022566e-09 -0.205187542504956 0.592779843960441 MirTarget -0.135972340055295 0.00312618231261177 NA NA NA hsa-miR-106b-5p NID1 2.80565545918114 1.14547999022566e-09 -2.37081065229977 0.00790016363881519 miRNAWalker2_validate -0.249576945178702 0.0212499484495152 NA NA NA hsa-miR-15b-3p NID1 3.57530146629867 5.89922785773482e-11 -2.37081065229977 0.00790016363881519 MirTarget;miRNATAP -0.296432832640239 0.00101810005815655 NA NA NA hsa-miR-15b-5p NISCH 3.32329949959268 8.40210501034588e-13 -1.07981474514221 0.00157510627939152 MirTarget -0.100312030543429 0.0133543143790882 NA NA NA hsa-miR-21-5p NKIRAS1 2.65163477806992 6.72089787690756e-16 -1.17039037534768 0.00124483241332596 MirTarget -0.143039556605321 0.0192524285410873 NA NA NA hsa-miR-106b-5p NKX3-2 2.80565545918114 1.14547999022566e-09 -2.74128369133808 0.0260665690875604 miRNATAP -0.3061500981532 0.0405613739198675 NA NA NA hsa-miR-15b-3p NLGN1 3.57530146629867 5.89922785773482e-11 -4.27653598114571 0.00407990579948399 mirMAP -0.316606483301335 0.0366963560130038 NA NA NA hsa-miR-21-3p NLGN4X 3.50297439576639 6.39946844099206e-10 -3.16125360101453 0.0508118994850833 MirTarget -0.573803323267076 0.000269352925556823 NA NA NA hsa-miR-106b-5p NMUR2 2.80565545918114 1.14547999022566e-09 -1.96382284935898 0.138712929699597 MirTarget -0.318512171592645 0.0473862459263132 NA NA NA hsa-miR-15b-5p NOTCH2 3.32329949959268 8.40210501034588e-13 -0.183005214639284 0.701542660353885 MirTarget -0.159555953544984 0.0045875298736748 NA NA NA hsa-miR-15b-5p NOVA2 3.32329949959268 8.40210501034588e-13 -3.3500847019059 1.2504810193861e-07 mirMAP -0.418832573333102 2.43469378721276e-08 NA NA NA hsa-miR-106b-5p NOX5 2.80565545918114 1.14547999022566e-09 -1.66774988819366 0.179288575504511 mirMAP -0.376402804344998 0.01212725807563 NA NA NA hsa-miR-21-5p NPAS3 2.65163477806992 6.72089787690756e-16 -4.05092648109092 0.000869766745666176 miRNATAP -0.964440356730118 2.10929603419056e-06 NA NA NA hsa-miR-106b-5p NPAT 2.80565545918114 1.14547999022566e-09 0.0890079323385136 0.818861659352856 MirTarget;miRNATAP -0.120193014197495 0.0100449711572266 NA NA NA hsa-miR-99a-5p NPM3 -2.72139054000803 0.00621971944534118 0.312434595337662 0.51427422271709 miRNAWalker2_validate -0.109258693058355 4.6486506524934e-05 NA NA NA hsa-miR-21-5p NTF3 2.65163477806992 6.72089787690756e-16 -3.48574436830551 0.00527602357381811 miRTarBase;miRNATAP -0.72373377555354 0.000571440631212767 NA NA NA hsa-miR-106b-5p NTN4 2.80565545918114 1.14547999022566e-09 -1.0780266974109 0.273120743968285 MirTarget;miRNATAP -0.383953196787263 0.00117929595684482 NA NA NA hsa-miR-21-5p NTRK2 2.65163477806992 6.72089787690756e-16 -1.54248853110693 0.400878993948488 mirMAP -0.607974471929539 0.0491535696073438 NA NA NA hsa-miR-106b-5p NTRK3 2.80565545918114 1.14547999022566e-09 -6.52653079118781 1.50303250706945e-07 mirMAP -0.88176331031583 3.97934581330512e-09 NA NA NA hsa-miR-15b-3p NTRK3 3.57530146629867 5.89922785773482e-11 -6.52653079118781 1.50303250706945e-07 mirMAP -0.912868199157279 1.3462551359347e-13 NA NA NA hsa-miR-21-3p NTRK3 3.50297439576639 6.39946844099206e-10 -6.52653079118781 1.50303250706945e-07 mirMAP -0.715787073845187 3.40385687980929e-09 NA NA NA hsa-miR-21-5p NTRK3 2.65163477806992 6.72089787690756e-16 -6.52653079118781 1.50303250706945e-07 mirMAP -0.491589963911927 0.021256308001167 NA NA NA hsa-miR-106b-5p NUAK1 2.80565545918114 1.14547999022566e-09 -2.19383560772227 0.00718120809751664 mirMAP -0.236123269407239 0.0171098839382082 NA NA NA hsa-miR-21-5p OSBPL1A 2.65163477806992 6.72089787690756e-16 -2.22204969621984 7.25180325238812e-05 miRNAWalker2_validate -0.260659035013428 0.00603976968797562 NA NA NA hsa-miR-15b-5p OSCAR 3.32329949959268 8.40210501034588e-13 0.876901035454418 0.196494118717125 MirTarget -0.245859281124526 0.00216152408344545 NA NA NA hsa-miR-106b-5p OSTM1 2.80565545918114 1.14547999022566e-09 -1.02726470769602 0.0035410552805802 miRNAWalker2_validate;MirTarget -0.111771619666919 0.00862679003982747 NA NA NA hsa-miR-21-5p PALLD 2.65163477806992 6.72089787690756e-16 -2.75699193701303 1.72115589923626e-07 miRNAWalker2_validate -0.210040758947708 0.0201312557919113 NA NA NA hsa-miR-15b-5p PAM 3.32329949959268 8.40210501034588e-13 -2.0988433486132 0.000121460186299677 miRNATAP -0.24212754365733 0.00018991476213196 NA NA NA hsa-miR-15b-5p PAPPA 3.32329949959268 8.40210501034588e-13 -3.34013495865365 0.00412614758796182 MirTarget;miRNATAP -0.361298229471074 0.00916629433774555 NA NA NA hsa-miR-15b-3p PAQR8 3.57530146629867 5.89922785773482e-11 -0.958184856904654 0.154823720295722 mirMAP -0.158377833968808 0.0199629450139708 NA NA NA hsa-miR-21-3p PARD3B 3.50297439576639 6.39946844099206e-10 -2.46222644360127 0.0537543487251974 MirTarget -0.658193570227611 8.01744813457861e-08 NA NA NA hsa-miR-106b-5p PARK2 2.80565545918114 1.14547999022566e-09 -4.51700969450779 7.71026345735979e-06 mirMAP -0.539044063100138 1.07908459633829e-05 NA NA NA hsa-miR-15b-5p PARVA 3.32329949959268 8.40210501034588e-13 -2.29686044432939 3.78154752549502e-07 MirTarget -0.158554608459432 0.00354837002662064 NA NA NA hsa-miR-21-5p PBRM1 2.65163477806992 6.72089787690756e-16 -0.220396207324232 0.543958940545396 miRNAWalker2_validate -0.170157447352035 0.00499075700710246 NA NA NA hsa-miR-21-5p PBX1 2.65163477806992 6.72089787690756e-16 -2.53948207392848 0.000100369399002374 miRNAWalker2_validate -0.405027904775025 0.00023598878386137 NA NA NA hsa-miR-106b-5p PBX3 2.80565545918114 1.14547999022566e-09 -0.505558470888791 0.295123716408401 miRNATAP -0.163285858147943 0.00494182736397606 NA NA NA hsa-miR-21-5p PCBP2 2.65163477806992 6.72089787690756e-16 -0.263506905621027 0.210230472170051 MirTarget;miRNATAP -0.104936901886574 0.00251166055768691 NA NA NA hsa-miR-15b-5p PCDH17 3.32329949959268 8.40210501034588e-13 -1.8574501551694 0.00917657523721329 MirTarget;miRNATAP -0.419755789705578 4.91611009798017e-07 NA NA NA hsa-miR-21-3p PCDH19 3.50297439576639 6.39946844099206e-10 -3.2215717435108 0.0745923153529791 MirTarget -0.995918094620428 8.48601695920462e-09 NA NA NA hsa-miR-15b-5p PCDH9 3.32329949959268 8.40210501034588e-13 -3.90343983308171 0.00338391623347688 MirTarget;miRNATAP -0.561962571746415 0.000372563655942154 NA NA NA hsa-miR-15b-5p PCDHA1 3.32329949959268 8.40210501034588e-13 -3.31157559877263 0.0306569973495579 MirTarget -0.545216491572057 0.0026807459286867 NA NA NA hsa-miR-21-3p PCDHA1 3.50297439576639 6.39946844099206e-10 -3.31157559877263 0.0306569973495579 MirTarget -0.492755339525539 0.000978533158306798 NA NA NA hsa-miR-15b-5p PCDHA10 3.32329949959268 8.40210501034588e-13 -5.95036695098701 0.000255458564742171 MirTarget -0.606040670100487 0.00179814193249125 NA NA NA hsa-miR-106b-5p PCDHA11 2.80565545918114 1.14547999022566e-09 -4.11053362571764 0.0146570994937415 MirTarget -0.541689219057611 0.00795302063065142 NA NA NA hsa-miR-15b-5p PCDHA11 3.32329949959268 8.40210501034588e-13 -4.11053362571764 0.0146570994937415 MirTarget -0.550906316362348 0.00589814430337402 NA NA NA hsa-miR-21-3p PCDHA11 3.50297439576639 6.39946844099206e-10 -4.11053362571764 0.0146570994937415 MirTarget -0.550531252936229 0.000814291054663162 NA NA NA hsa-miR-21-3p PCDHA12 3.50297439576639 6.39946844099206e-10 -3.47732855946625 0.0478045254910172 MirTarget -0.419388329628342 0.0147637107066988 NA NA NA hsa-miR-15b-5p PCDHA13 3.32329949959268 8.40210501034588e-13 -1.28262052613628 0.366191940804304 MirTarget -0.40515583203572 0.0159801481368823 NA NA NA hsa-miR-21-3p PCDHA13 3.50297439576639 6.39946844099206e-10 -1.28262052613628 0.366191940804304 MirTarget -0.32875638267869 0.0177190064050753 NA NA NA hsa-miR-106b-5p PCDHA2 2.80565545918114 1.14547999022566e-09 -3.69141491032228 0.00651756170845632 MirTarget -0.389664745926092 0.0180579094413723 NA NA NA hsa-miR-15b-5p PCDHA2 3.32329949959268 8.40210501034588e-13 -3.69141491032228 0.00651756170845632 MirTarget -0.601168085150835 0.000180443279910513 NA NA NA hsa-miR-21-3p PCDHA2 3.50297439576639 6.39946844099206e-10 -3.69141491032228 0.00651756170845632 MirTarget -0.609205743716304 3.62702057994812e-06 NA NA NA hsa-miR-106b-5p PCDHA3 2.80565545918114 1.14547999022566e-09 -6.11738879554056 7.63704652665282e-06 MirTarget -0.581775924146465 0.000488240079711562 NA NA NA hsa-miR-15b-5p PCDHA3 3.32329949959268 8.40210501034588e-13 -6.11738879554056 7.63704652665282e-06 MirTarget -0.660910066950292 5.05273260885942e-05 NA NA NA hsa-miR-21-3p PCDHA3 3.50297439576639 6.39946844099206e-10 -6.11738879554056 7.63704652665282e-06 MirTarget -0.755244228247707 1.25766720480879e-08 NA NA NA hsa-miR-15b-5p PCDHA4 3.32329949959268 8.40210501034588e-13 -2.82060359051135 0.165106514935505 MirTarget -0.518742714440964 0.0315170235896019 NA NA NA hsa-miR-21-3p PCDHA4 3.50297439576639 6.39946844099206e-10 -2.82060359051135 0.165106514935505 MirTarget -0.703114606330832 0.000371810005086324 NA NA NA hsa-miR-21-3p PCDHA5 3.50297439576639 6.39946844099206e-10 -4.19166725280424 0.0046968409446967 MirTarget -0.513062923724315 0.000396697657774816 NA NA NA hsa-miR-106b-5p PCDHA6 2.80565545918114 1.14547999022566e-09 -4.04848433770912 0.00840805895856843 MirTarget;miRNATAP -0.687470200607618 0.000207369306058501 NA NA NA hsa-miR-15b-5p PCDHA6 3.32329949959268 8.40210501034588e-13 -4.04848433770912 0.00840805895856843 MirTarget;miRNATAP -0.588899157797879 0.00123101189740263 NA NA NA hsa-miR-21-3p PCDHA6 3.50297439576639 6.39946844099206e-10 -4.04848433770912 0.00840805895856843 MirTarget -0.828352806795663 2.03678322275242e-08 NA NA NA hsa-miR-15b-5p PCDHA7 3.32329949959268 8.40210501034588e-13 -3.1637016005869 0.016864191414635 MirTarget -0.360156163333155 0.0222417138898478 NA NA NA hsa-miR-21-3p PCDHA7 3.50297439576639 6.39946844099206e-10 -3.1637016005869 0.016864191414635 MirTarget -0.48335697884412 0.000177472881050158 NA NA NA hsa-miR-21-3p PCDHAC1 3.50297439576639 6.39946844099206e-10 -2.26157463901718 0.19960161209619 MirTarget -0.344796671739494 0.0457154495148199 NA NA NA hsa-miR-21-3p PCDHAC2 3.50297439576639 6.39946844099206e-10 -3.00678191313989 0.112433742438206 MirTarget -0.644569294729451 0.000469730166506764 NA NA NA hsa-miR-21-3p PCMTD2 3.50297439576639 6.39946844099206e-10 -0.934190080875945 0.0119839632541072 MirTarget -0.232166881496648 4.32889026228559e-11 NA NA NA hsa-miR-30a-5p PCNA -0.768430903969183 0.320487552854215 2.73335198670389 1.37036078211483e-12 miRNAWalker2_validate -0.111427447791644 0.000130266569415098 NA NA NA hsa-miR-106b-5p PCSK5 2.80565545918114 1.14547999022566e-09 -1.33184919204153 0.252013141396813 mirMAP -0.316221649937308 0.0244742500106381 NA NA NA hsa-miR-106b-5p PDCD1LG2 2.80565545918114 1.14547999022566e-09 -0.814281776977562 0.398629580907516 MirTarget -0.388300518043059 0.000812785897034323 NA NA NA hsa-miR-15b-5p PDCD4 3.32329949959268 8.40210501034588e-13 -1.07702911413723 0.0139352247911728 MirTarget;miRNATAP -0.160089104899182 0.00199193535583411 NA NA NA hsa-miR-21-5p PDCD4 2.65163477806992 6.72089787690756e-16 -1.07702911413723 0.0139352247911728 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.180847901531443 0.0140836670120127 19682430;25575817;25316501;22072622;22267128;22322403;19836969;22212233;23604124;25520758;23272133;25477028;26252635;25994220;25991676;22747440;23827854;23824073;24865582;24902663;24888238;24149370;20978511;17991735;22689922;27355932;19308091;24331411;26169933;22547075;20372781;23558936;23201752;20815812;17968323;25310697;21842656;23567619;20581857;23888942;23548551;19013014;21685938;26142886;24472409;25973032;26418978;24659669;22086602;26212010;25543482;25543261;23904372;27725205;23564788;25400316;26150475;21546206;19509156;27035745;23052036;22353043;19633292;25566594;21412018;19276261;21330826;26864640;22335905;21636706 MicroRNA 21 promotes cell proliferation and down regulates the expression of programmed cell death 4 PDCD4 in HeLa cervical carcinoma cells; In this study we found that the inhibition of miR-21 in HeLa cervical cancer cells caused profound suppression of cell proliferation and up-regulated the expression of the tumor suppressor gene PDCD4;We identified miR-21 was directly downregulated by RBP2 and found that miR-21 downregulated PDCD4 expression in leukemia cells;MTCs were consistently associated with miR-21 up-regulation P < .0016 and featured significant PDCD4 nuclear down-regulation; An inverse correlation emerged between miR-21 overexpression and PDCD4 down-regulation P = .0013; This study showed in MTCs that miR-21 regulates PDCD4 expression and also that the miR-21/PDCD4 pathway correlates with clinicopathological variables and prognosis;Although microRNA-21 miR-21 is emerging as an oncogene and has been shown to target several tumor suppressor genes including programmed cell death 4 PDCD4 its precise mechanism of action on cancer stem cells CSCs is unclear; Herein we report that FOLFOX-resistant HCT-116 and HT-29 cells that are enriched in CSCs show a 3- to 7-fold upregulation of pre- and mature miR-21 and downregulation of PDCD4; Likewise overexpression of miR-21 in HCT-116 cells achieved through stable transfection led to the downregulation of PDCD4 and transforming growth factor beta receptor 2 TGFβR2;Prognostic significance of PDCD4 expression and association with microRNA 21 in each Dukes' stage of colorectal cancer patients; Furthermore relationships between the PDCD4 mRNA and microRNA-21 miR-21 were evaluated; The PDCD4 mRNA was investigated by the quantitative real-time RT-PCR method and miR-21 was examined by TaqMan microRNA assays; Significant inverse correlations were demonstrated between PDCD4 and miR-21;miR 21 promotes migration and invasion by the miR 21 PDCD4 AP 1 feedback loop in human hepatocellular carcinoma; The expression level of miR-21 was inversely correlated with the protein expression level of a previously identified target gene programmed cell death 4 PDCD4;This short review will focus on our recent finding that the microRNA miR-21 posttranscriptionally regulates Pdcd4 as well as invasion intravasation and metastasis;PDCD4 expression inversely correlated with miR 21 levels in gastric cancers;HBx mediated miR 21 upregulation represses tumor suppressor function of PDCD4 in hepatocellular carcinoma; HBx downregulates PDCD4 expression at least partially through miR-21; Taken together this study reported for the first time that HBx downregulates PDCD4 and upregulates miR-21 expression; The deregulation of PDCD4 by HBx through miR-21 represents a potential novel mechanism of the downregulation of PDCD4 in HBV-related HCC and provides new insights into HCC development;MicroRNA 21 Down regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma; MicroRNA-21 miR-21 possesses the oncogenic potential to target several tumor suppressor genes including PDCD4 and regulates tumor progression and metastasis; However the mechanism of how miR-21 regulates PDCD4 is poorly understood in RB; Using the TargetScan program we identified a list of potential target genes of these miRNAs of which PDCD4 is one the targets of miR-21; In this study we focused on the regulatory mechanism of miR-21 on PDCD4 in RB; We demonstrated an inverse correlation between miR-21 and PDCD4 expression in Weri-Rb1 and Y79 cells; These data suggest that miR-21 down-regulates Rb1 by targeting PDCD4 tumor suppressor;Additionally resveratrol increased the expression of tumor suppressors PDCD4 and maspin which are negatively regulated by miR-21; Short interfering si RNA against PDCD4 attenuated resveratrol's effect on prostate cancer cells and similar effects were observed following over expression of miR-21 with pre-miR-21 oligonucleotides; MiR-21 expression in these cells appeared to be dependent on Akt as LY294002 reduced the levels of miR-21 along with a concurrent increase in PDCD4 expression; These tumor- and metastatic-suppressive effects of resveratrol were associated with reduced miR-21 and pAkt and elevated PDCD4 levels;The expression of miR-21 and PDCD4 mRNA in transfected cells was quantified by real-time polymerase chain reaction and the expression of PDCD4 protein by Western blot; Cell proliferation apoptosis migration and invasion assays were performed to determine the biological effects of miR-21 expression and PDCD4 inhibition; Co-transfection of miR-21-sponge with PDCD4 siRNA upregulated miR-21 expression in these cells; PDCD4 mRNA and protein levels were increased 2.14-fold and 2.16-fold respectively following inhibition of miR-21 expression; Depletion of PDCD4 by siRNA transfection reversed the reduction of cell proliferation migration and invasion induced by inhibition of miR-21 in A549 cells; It indicates that miR-21 is highly expressed in patients with NSCLC and inhibition of miR-21 expression reduces proliferation migration and invasion of A549 cells by upregulating PDCD4 expression; Modulation of miR-21 or PDCD4 expression may provide a potentially novel therapeutic approach for NSCLC;IL 6 Inhibits the Targeted Modulation of PDCD4 by miR 21 in Prostate Cancer; In this study we evaluated the role of IL-6 in PDCD4 gene expression and how the microRNA miR-21 regulates this process in prostate cancer cell lines PC-3 and LNCaP; The expression of PDCD4 was inhibited by IL-6 but this effect was weakened in cell lines with low expression of miR-21; These findings support the feasibility of future efforts for diagnosis and gene therapy for prostate cancer that are based on IL-6 miR-21 and PDCD4;Furthermore the absence of miR-21 increased the expression of its target gene PDCD4 and subsequently modulated nuclear factor NF-κB activation;In this study using reverse phase protein arrays RPPAs we assessed MPS1 mediated cell signaling pathways and demonstrated that inhibiting MPS1 could upregulate the expression of the tumor suppressor PDCD4 and MSH2 genes by down regulating micro RNA-21 miR-21; We also show the prognostic effect of miR21 PDCD4 and MSH2 levels to patient survival across different GBM molecular subtypes;We also analyzed the immunohistochemical expression of PDCD4 an miR-21 gene target; PDCD4 expression was significantly downregulated in MTC samples consistent with miR-21 upregulation;Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA 21 mediated programmed cell death 4 PDCD4 expression; Further AR inhibition also increased PDCD4 a putative target of miR-21 in human colon cancer cells; Collectively these results indicate that AR inhibition prevents growth factor-induced colon cancer growth by down-regulating miR-21 expression and increasing PDCD4 levels through the reactive oxygen species ROS/AMPK/mTOR/AP1/4E-BP1 pathway;Berberine could inhibit miR-21 expression and function in ovarian cancer as shown by an enhancement of its target PDCD4 an important tumor suppressor in ovarian cancer;Overexpression of miR-21 in cisplatin sensitive cells decreased PDCD4 levels and increased cell proliferation;MicroRNA 21 miR 21 post transcriptionally downregulates tumor suppressor PDCD4 and promotes cell transformation proliferation and metastasis in renal cell carcinoma; MiR-21 induces neoplastic transformation cell proliferation and metastasis and downregulates programmed cell death4 PDCD4 in some cancers; The aim of this study was to investigate the roles and interactions of PDCD4 and miR-21 in human renal cell carcinoma RCC; The expression levels of PDCD4 protein and mRNA and miR-21 were examined by Western blot analysis and by qRT-PCR and luciferase reporter assays; MiR-21 not only promoted cancer cell hyperplasia and contributed to tumor cell transformation and metastasis but also post-transcriptionally downregulated PDCD4 protein expression; PDCD4 and miR-21 expression levels potentially play an important role in renal cell cancer;Programmed cell death 4 PDCD4 is a tumor suppressor gene whose expression is directly controlled by microRNA-21 miR-21; This PDCD4 and miR-21 inverse expression was also noted in cells and exosomes from OSC peritoneal effusions compared with nonneoplastic effusions; PDCD4 and miR-21 are involved in OSC oncogenesis;Finally in a subgroup of tumor specimens ROC curve analysis performed on quantitative PCR data sets for miR-21 ITGβ4 and PDCD4 shows that the combination of high miR-21 with low ITGβ4 and PDCD4 expression is able to predict presence of metastasis; In conclusion miR-21 is a key player in oncogenic EMT its overexpression is controlled by the cooperation of genetic and epigenetic alterations and its levels along with ITGβ4 and PDCD4 expression could be exploited as a prognostic tool for CRC metastasis;Transfection of anti-miR-21 rendered HCC cells sensitive to IFN-α/5-FU and such sensitivity was weakened by transfection of siRNAs of target molecules PETN and PDCD4 miR-21 expression in clinical HCC specimens was significantly associated with the clinical response to the IFN-α/5-FU combination therapy and survival rate;Programmed cell death 4 PDCD4 is an important functional target of the microRNA miR 21 in breast cancer cells;In ZD esophagus and tongue oncogenic miR-31 and miR-21 overexpression was accompanied by down-regulation of their respective tumor-suppressor targets PPP2R2A and PDCD4;Due to inhibition of miR-21 expression of the programed cell death 4 PDCD4 gene was promoted in tumors resulting in the induction of apoptosis of tumor cells;We also demonstrated that BMP-6-induced downregulation of miR-21 modified the activity of PDCD4 3'UTR and inhibited MDA-MB-231 cell invasion;The level of miR-21 was reversely correlated with the expression of PTEN and PDCD4 and positive correlated with PI3K/Akt pathway; miR-21 is involved in acquired resistance of EGFR-TKI in NSCLC which is mediated by down-regulating PTEN and PDCD4 and activating PI3K/Akt pathway;The results indicated that the miR-21 inhibition could induce the cell cycle arrest in G1 phase upregulate the expression of Programmed Cell Death Protein 4 PDCD4 and thus active the caspase-3 apoptosis pathway;Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4;Clinicopathological and prognostic significance of PDCD4 and microRNA 21 in human gastric cancer; Recent studies have demonstrated that the novel tumor suppressor protein programmed cell death 4 PDCD4 is downregulated in several human solid cancer types and is suppressed by microRNA-21 miR-21; The objectives of this study were: i to establish the clinicopathological and prognostic significance of PDCD4 mRNA and ii to elucidate any correlation between PDCD4 mRNA and miR-21 in gastric cancer; We also performed an association study comparing PDCD4 mRNA and miR-21 in eight cell lines and 49 gastric cancers; An inverse correlation between PDCD4 mRNA and miR-21 was found in gastric cancer; Furthermore our findings suggest that PDCD4 mRNA is negatively regulated by miR-21 in gastric cancer and may serve as a target for effective therapies;Furthermore miR-21 mimic or inhibitor significantly reduced or increased the expression of PDCD4 and TPM1; MiR-21 is overexpressed in RCC tissue and modulates the growth apoptosis and cell cycle progression of RCC cells and regulates the expression of PDCD4 and TPM1;Moreover we demonstrate that oligonucleotide-mediated miR-21 silencing in U87 human GBM cells resulted in increased levels of the tumor suppressors PTEN and PDCD4 caspase 3/7 activation and decreased tumor cell proliferation;Curcumin treatment reduced miR-21 promoter activity and expression in a dose-dependent manner by inhibiting AP-1 binding to the promoter and induced the expression of the tumour suppressor Pdcd4 programmed cell death protein 4 which is a target of miR-21; Taken together this is the first paper to show that curcumin inhibits the transcriptional regulation of miR-21 via AP-1 suppresses cell proliferation tumour growth invasion and in vivo metastasis and stabilizes the expression of the tumour suppressor Pdcd4 in colorectal cancer;MicroRNA 21 miR 21 post transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion intravasation and metastasis in colorectal cancer; This is the first study to show that Pdcd4 is negatively regulated by miR-21;Inflammation and MiR 21 pathways functionally interact to downregulate PDCD4 in colorectal cancer; These findings indicate that miR-21 is a component of the COX-2 inflammation pathway and that this pathway promotes worsening of disease stage in colorectal cancer by inducing accumulation of PGE2 and increasing expression of miR-21 with consequent downregulation of the tumour suppressor gene PDCD4;The expression of miR-21 PTEN and PDCD4 were determined by Real-time PCR; Glossy ganoderma spore oil down-regulated the expression of miR-21 and up-regulated the expression of PTEN and PDCD4 significantly;Interestingly NVP-LDE-225 induced PDCD4 and apoptosis and inhibited cell viability by suppressing miR-21;PDCD4 a direct target gene of miR-21 could mediate chemoresistance to docetaxel in PC3 cells;Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR 21; The expression of miR-21 and PDCD4 was highly correlated with the degree of differentiation tumor staging local lymphatic node metastasis and remote metastasis; In addition the relative expression of PDCD4 was negatively correlated with miR-21; Thus we conclude that ROS promotes gastric carcinogenesis via upregulating miR-21 expression which in turn down-regulates the expression of PDCD4 in gastric cancer cells;Moreover knockdown of miR-21 increased PDCD4 and PTEN expression at the protein level but not at the mRNA level;MicroRNA 21 down regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G; Expression of PDCD4 protein correlates inversely with expression of miR-21 in a number of human glioblastoma cell lines such as T98G A172 U87 and U251; Inhibition of miR-21 increases endogenous levels of PDCD4 in cell line T98G and over-expression miR-21 inhibits PDCD4-dependent apoptosis;Treatment of HSC-3 cells with Nanog- and/or Stat-3-specific small interfering RNAs effectively blocks HA-mediated Nanog-Stat-3 signaling events abrogates miR-21 production and increases PDCD4 expression;Programmed cell death 4 PDCD4 is critical in mediating apoptosis in GBM and is downregulated by miR-21 which may mediate the resistance of glioblastoma cells against chemotherapy or radiation via its target genes PDCD4; This review will focus on the roles of miRNAs family members particularly miR-21 and its target gene PDCD4 in tumors like glioblastoma and new targeting strategies as examples some new targeting therapeutic methods and molecular mechanisms of signal pathways in glioblastoma therapeutics to give the reader the current trends of approach to target regulation of these miRNA and genes for future glioma therapies;Using Western blot analysis miR-21 knockdown enhanced the expression of tumor suppressor PDCD4 and attenuated apoptosis inhibitor c-IAP2;PDCD4 and PTEN expression was decreased gradually after tumor induction and negatively correlated with miR-21 expression; Our in vivo experiments further confirmed that miR-21 plays an important role in promoting the occurrence and development of HCC by regulating PDCD4 and PTEN;METHODS 3-45-dimethylthiazol-2-yl-25-diphenyltetrazolium bromide MTT assay was used to determine the effect of 5-FU on the viability of RKO cells with knockout of miR-21 or high expression of PDCD4;The protein levels of miR-21 targets PTEN and PDCD4 were estimated; In the control experiment miR-21 mimic significantly inhibited the expression of PTEN and PDCD4 proteins in the two gastric cell lines leading to an increase in cell invasion and migration; miR-21 is overexpressed in gastric cancer and its aberrant expression may have important role in gastric cancer growth and dissemination by modulating the expression of the tumor suppressors PTEN and PDCD4 as well as by modulating the pathways involved in mediating cell growth migration invasion and apoptosis;The effects were accompanied by up-regulation of tumor suppressor PDCD4 a known miR-21 target; as well as up-regulation of cofilin and profilin two key proteins involved in actin polymerization and cytoskeleton maintenance as a consequence of miR-182 down-regulation;Increased levels of miR-21 in turn downregulate the expression of the metastasis-suppressor protein programmed cell death 4 PDCD4 a validated miR-21 target;Moreover knockdown of miR-21 increased the expressions of PDCD4 and PTEN at the protein level but not at the mRNA level;In this study we analyzed the expression of miR-21 and of its target PDCD4 Programmed Cell Death 4 during normal hematopoietic differentiation and in AMLs;MiR 21 mediates the radiation resistance of glioblastoma cells by regulating PDCD4 and hMSH2; In addition miR-21 knockdown increased the expression of endogenous PDCD4 and hMSH2 which contributed to the apoptosis and G2 arrest of T98G cells; The findings suggested that miR-21 may mediate the resistance of glioblastoma cells against radiation via its target genes PDCD4 and hMSH2;The results showed that upon exposure to mUA miR-21 expression was decreased and the expression of PTEN and Pdcd4 protein was elevated;The expression of programmed cell death-4 PDCD4 was increased by I3C and reduced by miR-21 transfection; Such enhanced chemosensitivity might be explained by the increased expression of PDCD4 which is a downstream target which miR-21 negatively regulates;It has been reported that miR-21 was upregulated in most malignant cancers the proposed mechanism of which was through suppressing expression of programmed cell death 4 PDCD4; In present study it is firstly reported that miR-21 was upregulated in Kazakh's ESCC and that miR-21 played a negative role in regulating PDCD4 using in situ hybridization ISH and luciferase reporter approach;To measure levels of microRNA miR-21 and its target gene programmed cell death 4 PDCD4 in samples of human cutaneous malignant melanoma and normal non-malignant control skin; Relative levels of miR-21 and PDCD4 mRNA were measured using a quantitative real-time reverse transcription-polymerase chain reaction; Compared with normal skin samples the relative level of miR-21 was significantly higher and the relative level of PDCD4 mRNA was significantly lower in the melanoma specimens; A significant negative correlation between PDCD4 mRNA and miR-21 was demonstrated in malignant melanoma r = -0.602; Elevated miR-21 and reduced PDCD4 mRNA levels were both significantly correlated with increased tumour size a higher Clark classification level and the presence of lymph node metastases in malignant melanoma; These findings suggest that miR-21 and PDCD4 might be potential biomarkers for malignant melanoma and might provide treatment targets in the future;MicroRNA 21 and PDCD4 expression in colorectal cancer; Studies have shown that miR-21 exerts its oncogenic activity by targeting the PDCD4 tumour suppressor 3'-UTR; The purpose of this study was to delineate the interaction between PDCD4 and its oncogenic modulator miR-21 in colorectal cancer; A cohort of 48 colorectal tumours 61 normal tissues and 7 polyps were profiled for miR-21 and PDCD4 gene expression; A significant inverse relationship between miR-21 and PDCD4 gene expression p < 0.001 was identified by RT-qPCR; In addition significant reduction of PDCD4 p < 0.001 expression and reciprocal upregulation of miR-21 p = 0.005 in a progressive manner from tumour-polyp-normal mucosae was identified; This study demonstrates the inverse relationship between miR-21 and PDCD4 thus suggesting that miR-21 post-transcriptionally modulates PDCD4 via mRNA degradation;Expression patterns of miR-21 RNA and its target tumor suppressor protein PDCD4 were mutually exclusive;Exosome shuttling microRNA 21 promotes cell migration and invasion targeting PDCD4 in esophageal cancer;Fenhexamid and fludioxonil stimulated miR-21 expression in a concentration-dependent manner and reduced the expression of miR-21 target Pdcd4 protein; Antisense to miR-21 blocked the increase in Pdcd4 protein by fenhexamid and fludioxonil;The expression of programmed cell death 4 PDCD4 which is a miR-21 targeting apoptotic gene has also been enhanced by UA; And over-expression of miR-21 in U251 cells abolished the enhancement of PDCD4 protein by UA;This process leads to microRNA-21 miR-21 production and a tumor suppressor protein e.g PDCD4 program cell death 4 reduction; Transfection of MCF-7 cells with PKCepsilon or Nanog-specific small interfering RNAs effectively blocks HA-mediated PKCepsilon-Nanog signaling events abrogates miR-21 production and increases PDCD4 expression/eIF4A binding;Through dual-luciferase method it was verified that PDCD4 and PDCD10 were real target genes of miR-21 and miR-200c respectively;miR-21 and miR-155 expression was assessed in tumor tissue and in adjacent normal tissue of 156 CRC patients by TaqMan MicroRNA assays and PDCD4 and TP53INP1 mRNA levels were measured by quantitative real-time reverse transcriptase PCR RT-PCR; Significant inverse correlations were demonstrated between miR-21 and PDCD4 mRNA and miR-155 and TP53INP1 mRNA;The aim of this study was a to determine a role of microRNA-21 in esophageal squamous cell carcinoma and b to elucidate the regulation of the programmed cell death 4 PDCD4 gene by microRNA-21; In addition the regulation of PDCD4 by microRNA-21 was elucidated to identify the mechanisms of this regulation; The PDCD4 protein levels in esophageal squamous cell carcinoma cells have an inverse correlation with microRNA-21 expression; MicroRNA-21 targets PDCD4 at the posttranscriptional level and regulates cell proliferation and invasion in esophageal squamous cell carcinoma;Maspin Pdcd4 and miR-21 expressions were evaluated by a real-time polymerase chain reaction in 20 endometrial cancer and 10 normal endometrium samples; Comparison between IA and more advanced International Federation of Gynecology and Obstetrics stages of endometrial cancer in regard to expression levels of maspin Pdcd4 and miR-21 did not reveal any significant differences;MicroRNA 21 induces 5 fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4; The proresistance effects of miR-21 were attributed to the attenuated expression of tumor suppressor genes including PTEN and PDCD4;Sequence prediction and gene expression regulation assays showed that miR-21 could reversely regulate the expression of PDCD4 P < 0.01; Suppression of miR-21 expression is associated with an elevation of Pdcd4 resulting in a significant reduction of proliferation and the apoptosis rate 2.6% was increased to 10.9%; Moreover the anti-proliferation and pro-apoptotic effect by miR-21 suppression could be reversed by PDCD4 knock down;Downregulation of Pdcd4 by mir 21 facilitates glioblastoma proliferation in vivo; We demonstrate that downregulation of mir-21 in glioblastoma-derived cell lines results in increased expression of its target programmed cell death 4 Pdcd4 a known tumor-suppressor gene; In addition our data indicate that either downregulation of mir-21 or overexpression of its target Pdcd4 in glioblastoma-derived cell lines leads to decreased proliferation increased apoptosis and decreased colony formation in soft agar; Using a glioblastoma xenograft model in immune-deficient nude mice we observe that glioblastoma-derived cell lines in which mir-21 levels are downregulated or Pdcd4 is over-expressed exhibit decreased tumor formation and growth; These critical in vivo findings demonstrate an important functional linkage between mir-21 and Pdcd4 and further elucidate the molecular mechanisms by which the known high level of mir-21 expression in glioblastoma can attribute to tumorigenesis--namely inhibition of Pdcd4 and its tumor-suppressive functions ;;worse prognosis;;staging;;metastasis;;;metastasis;progression;;;;;poor survival;;;;;metastasis;;metastasis;poor survival;drug resistance;;;;;drug resistance;;;;progression;;metastasis;metastasis;staging;;;drug resistance;staging;metastasis;differentiation;tumorigenesis;;;;drug resistance;;;;;;metastasis;;differentiation;drug resistance;;;malignant trasformation;malignant trasformation;metastasis;progression;;cell migration;;;;;;;staging;drug resistance;;tumorigenesis cervical and endocervical cancer;chronic myeloid leukemia;thyroid cancer;colon cancer;colorectal cancer;liver cancer;colon cancer;gastric cancer;liver cancer;retinoblastoma;prostate cancer;lung squamous cell cancer;prostate cancer;colorectal cancer;glioblastoma;thyroid cancer;colon cancer;ovarian cancer;ovarian cancer;kidney renal cell cancer;ovarian cancer;colorectal cancer;liver cancer;breast cancer;esophageal cancer;glioblastoma;breast cancer;lung squamous cell cancer;breast cancer;breast cancer;gastric cancer;kidney renal cell cancer;glioblastoma;colorectal cancer;colorectal cancer;colorectal cancer;lung cancer;prostate cancer;prostate cancer;gastric cancer;B cell lymphoma;glioblastoma;head and neck cancer;glioblastoma;ovarian cancer;liver cancer;colon cancer;gastric cancer;breast cancer;breast cancer;B cell lymphoma;acute myeloid leukemia;glioblastoma;prostate cancer;pancreatic cancer;esophageal cancer;melanoma;colorectal cancer;colorectal cancer;esophageal cancer;breast cancer;glioblastoma;breast cancer;breast cancer;colorectal cancer;esophageal cancer;endometrial cancer;pancreatic cancer;lung squamous cell cancer;glioblastoma hsa-miR-21-3p PDE3A 3.50297439576639 6.39946844099206e-10 -3.19583517215676 0.0450224244902953 mirMAP -0.646987208955195 2.8659394784979e-05 NA NA NA hsa-miR-106b-5p PDE7B 2.80565545918114 1.14547999022566e-09 -4.29424253758039 8.18621058906608e-08 mirMAP -0.347947590408061 0.000401484882419263 NA NA NA hsa-miR-21-5p PDGFD 2.65163477806992 6.72089787690756e-16 -3.47672449807147 2.67668711091569e-05 miRNAWalker2_validate -0.428672753870124 0.00228532529446352 NA NA NA hsa-miR-106b-5p PDGFRA 2.80565545918114 1.14547999022566e-09 -4.31615823709194 9.59580352063599e-06 MirTarget;miRNATAP -0.783177330311627 1.33145452797817e-11 NA NA NA hsa-miR-21-3p PDIK1L 3.50297439576639 6.39946844099206e-10 0.612996992128882 0.118814674886309 MirTarget -0.13755768151094 0.000299635837983411 NA NA NA hsa-miR-15b-5p PDK4 3.32329949959268 8.40210501034588e-13 -6.28288979709477 6.37804417591939e-07 MirTarget;miRNATAP -0.602396219829036 6.73135755785929e-05 NA NA NA hsa-miR-15b-5p PDLIM2 3.32329949959268 8.40210501034588e-13 -1.34462121059771 0.0315513806377373 mirMAP -0.227653280701787 0.00209338354278342 NA NA NA hsa-miR-15b-5p PDLIM5 3.32329949959268 8.40210501034588e-13 -1.71262132078673 7.73652509960697e-06 miRNATAP -0.133244974949815 0.00360749574671671 NA NA NA hsa-miR-21-3p PDP2 3.50297439576639 6.39946844099206e-10 0.0671961889612831 0.895298488910336 MirTarget -0.127832978355868 0.0100810906148867 NA NA NA hsa-miR-21-3p PDPR 3.50297439576639 6.39946844099206e-10 -0.3368707885996 0.580969849948668 mirMAP -0.244380624561412 3.37701455516355e-05 NA NA NA hsa-miR-21-3p PGPEP1 3.50297439576639 6.39946844099206e-10 -1.23689539704787 0.0577731359036174 mirMAP -0.19675799394383 0.00195292733760406 NA NA NA hsa-miR-106b-5p PGR 2.80565545918114 1.14547999022566e-09 -7.61800366113324 2.6407041334359e-07 mirMAP -1.0951431534951 7.37661332501304e-10 NA NA NA hsa-miR-21-5p PGRMC2 2.65163477806992 6.72089787690756e-16 -0.450376179015367 0.12167535480852 miRNAWalker2_validate -0.100090599945014 0.0396023820048822 NA NA NA hsa-miR-15b-3p PHACTR2 3.57530146629867 5.89922785773482e-11 -1.20309955473489 0.00845348018819827 mirMAP -0.130621106039942 0.00466967017815948 NA NA NA hsa-miR-15b-5p PHACTR2 3.32329949959268 8.40210501034588e-13 -1.20309955473489 0.00845348018819827 miRNATAP -0.108638279060157 0.0454771048206898 NA NA NA hsa-miR-21-3p PHC3 3.50297439576639 6.39946844099206e-10 0.0384175412599577 0.914125934295248 MirTarget -0.105502116887818 0.00222148449915654 NA NA NA hsa-miR-21-5p PHF14 2.65163477806992 6.72089787690756e-16 -0.0145606698902032 0.955698260564629 MirTarget -0.109361587699718 0.0120674914812976 NA NA NA hsa-miR-21-3p PHF2 3.50297439576639 6.39946844099206e-10 -0.653531219366689 0.0457778857173025 MirTarget -0.152275412005818 1.22260733325482e-06 NA NA NA hsa-miR-21-5p PHIP 2.65163477806992 6.72089787690756e-16 0.179329898414919 0.589103831920728 miRNAWalker2_validate -0.135057048466991 0.0148271040952044 NA NA NA hsa-miR-21-3p PHLPP2 3.50297439576639 6.39946844099206e-10 -1.08180409105584 0.0171506195284889 mirMAP -0.126517023286179 0.00427407826787136 NA NA NA hsa-miR-106b-5p PHYHIP 2.80565545918114 1.14547999022566e-09 -4.2606858156354 7.91054074739761e-06 miRNATAP -0.332669604693449 0.00437185866233278 NA NA NA hsa-miR-21-3p PHYHIPL 3.50297439576639 6.39946844099206e-10 -1.63199757454445 0.259180663551363 MirTarget -0.297819794419558 0.0352590923441643 NA NA NA hsa-miR-15b-3p PI15 3.57530146629867 5.89922785773482e-11 -4.89190864015848 9.82572824730675e-06 mirMAP -0.559199900061015 5.58731968637495e-07 NA NA NA hsa-miR-15b-5p PID1 3.32329949959268 8.40210501034588e-13 -4.40207517290598 4.47579673195812e-05 MirTarget;miRNATAP -0.520487351493603 4.95930489240211e-05 NA NA NA hsa-miR-21-5p PIK3C2A 2.65163477806992 6.72089787690756e-16 -0.773727815078786 0.0567725241204762 miRNAWalker2_validate -0.196586046328205 0.00384035963253757 NA NA NA hsa-miR-15b-5p PIK3C2B 3.32329949959268 8.40210501034588e-13 -0.463912022822832 0.355976678565411 miRNAWalker2_validate -0.203622535037947 0.000571332285094522 NA NA NA hsa-miR-21-5p PIK3R1 2.65163477806992 6.72089787690756e-16 -1.85375256159008 0.0127438113463991 miRNAWalker2_validate;MirTarget;miRNATAP -0.296975751298422 0.0179761051209979 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-21-5p PIKFYVE 2.65163477806992 6.72089787690756e-16 -0.444731017066681 0.267266758768259 MirTarget -0.168365949401605 0.0120914172864726 NA NA NA hsa-miR-21-5p PIP4K2B 2.65163477806992 6.72089787690756e-16 -0.9561493535699 0.000117956799826419 mirMAP -0.114226792677504 0.00615272137383702 NA NA NA hsa-miR-15b-5p PITPNM2 3.32329949959268 8.40210501034588e-13 -0.661897034941625 0.273705419886434 mirMAP -0.17445932368295 0.0147484338189364 NA NA NA hsa-miR-106b-5p PKD2 2.80565545918114 1.14547999022566e-09 -3.09768440647572 1.62717413226486e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.284419980848781 4.82859211702389e-07 NA NA NA hsa-miR-21-5p PKD2 2.65163477806992 6.72089787690756e-16 -3.09768440647572 1.62717413226486e-11 miRNAWalker2_validate -0.291070086720838 0.000245127759902737 NA NA NA hsa-miR-21-5p PLAG1 2.65163477806992 6.72089787690756e-16 -1.06158200230821 0.323427290944095 MirTarget;miRNATAP -0.402706999026214 0.0258859102773682 NA NA NA hsa-miR-21-3p PLCXD3 3.50297439576639 6.39946844099206e-10 -7.04776862392773 1.33665946282138e-07 mirMAP -0.936479805303534 3.00074908379368e-13 NA NA NA hsa-miR-106b-5p PLEKHA2 2.80565545918114 1.14547999022566e-09 -0.221418309377464 0.55897442997387 mirMAP -0.148091617501348 0.00109777321744728 NA NA NA hsa-miR-106b-5p PLEKHO2 2.80565545918114 1.14547999022566e-09 -1.67685658120932 2.63983249620034e-05 MirTarget;miRNATAP -0.264310686982395 3.00483577070338e-08 NA NA NA hsa-miR-21-3p PLGLB2 3.50297439576639 6.39946844099206e-10 0.496108809526647 0.348204314478411 MirTarget -0.111434069953883 0.0307591941216316 NA NA NA hsa-miR-106b-5p PLSCR4 2.80565545918114 1.14547999022566e-09 -2.23323587217554 0.00932106500691384 MirTarget -0.448770302114451 1.34142519391011e-05 NA NA NA hsa-miR-15b-5p PLXDC1 3.32329949959268 8.40210501034588e-13 -2.1823580186372 0.00118215514722911 mirMAP -0.457167329918885 5.6308970939774e-09 NA NA NA hsa-miR-15b-3p PLXNA2 3.57530146629867 5.89922785773482e-11 0.483563803401337 0.468236564156601 mirMAP -0.201931254505265 0.00261206475695662 NA NA NA hsa-miR-15b-5p PLXNA2 3.32329949959268 8.40210501034588e-13 0.483563803401337 0.468236564156601 MirTarget;miRNATAP -0.214080542270469 0.00656800012109935 NA NA NA hsa-miR-15b-5p PLXNC1 3.32329949959268 8.40210501034588e-13 -0.705833742044138 0.545902978988465 miRNATAP -0.494828202451276 0.000322770454869734 NA NA NA hsa-miR-21-5p PM20D2 2.65163477806992 6.72089787690756e-16 -0.195061142211067 0.706724167844137 miRNAWalker2_validate;MirTarget -0.292819860230947 0.000708610309667216 NA NA NA hsa-miR-15b-5p PMEPA1 3.32329949959268 8.40210501034588e-13 -0.442358517847733 0.562223736384141 mirMAP -0.287387323845076 0.00140613777638125 NA NA NA hsa-miR-15b-5p PNPLA6 3.32329949959268 8.40210501034588e-13 0.0063763993572783 0.984565837739391 MirTarget;miRNATAP -0.10506203136989 0.00668771917567522 NA NA NA hsa-miR-21-5p POLR3B 2.65163477806992 6.72089787690756e-16 0.479657540715836 0.124326366937993 miRNAWalker2_validate -0.114161206756552 0.0287412832362611 NA NA NA hsa-miR-15b-3p POU2F2 3.57530146629867 5.89922785773482e-11 0.118131373643654 0.86884454178052 miRNATAP -0.177317967020281 0.0139893080552522 NA NA NA hsa-miR-21-3p PPARGC1A 3.50297439576639 6.39946844099206e-10 -2.2640615933856 0.188718863271766 mirMAP -0.557358675737418 0.000884964316993151 NA NA NA hsa-miR-15b-5p PPM1K 3.32329949959268 8.40210501034588e-13 -3.21217087045589 7.67572055014218e-07 MirTarget -0.290272388789972 0.000192465710489332 NA NA NA hsa-miR-106b-5p PPM1L 2.80565545918114 1.14547999022566e-09 -0.144856452694688 0.874611356206177 mirMAP -0.253607670593155 0.022100659474786 NA NA NA hsa-miR-21-5p PPM1L 2.65163477806992 6.72089787690756e-16 -0.144856452694688 0.874611356206177 miRNAWalker2_validate -0.48706582026337 0.0015132433594985 NA NA NA hsa-miR-21-3p PPP1R1A 3.50297439576639 6.39946844099206e-10 -4.71558493294227 0.000879695410574919 MirTarget -0.895212065373902 3.79169899552151e-11 NA NA NA hsa-miR-125a-5p PRC1 -1.32352790615388 0.00714301627309467 3.91155027439105 1.96830343810997e-20 miRNAWalker2_validate -0.151589208240685 0.00354672882879816 NA NA NA hsa-miR-106b-5p PRELP 2.80565545918114 1.14547999022566e-09 -5.61626675274356 1.70477383130157e-06 mirMAP -1.06059814366123 1.72277068768246e-14 NA NA NA hsa-miR-21-5p PREPL 2.65163477806992 6.72089787690756e-16 -0.537976987735386 0.130418508525177 miRNAWalker2_validate -0.167254531485487 0.00489083736313936 NA NA NA hsa-miR-15b-3p PRICKLE2 3.57530146629867 5.89922785773482e-11 -3.45141746786942 2.23819194762863e-06 mirMAP -0.305418579191281 3.91799008722286e-05 NA NA NA hsa-miR-21-5p PRICKLE2 2.65163477806992 6.72089787690756e-16 -3.45141746786942 2.23819194762863e-06 miRNAWalker2_validate;MirTarget -0.411551709864877 0.000912823366410808 NA NA NA hsa-miR-21-3p PRKD1 3.50297439576639 6.39946844099206e-10 -3.37242340184957 0.00251240808884675 MirTarget -0.522419261354413 1.36202932164783e-06 NA NA NA hsa-miR-15b-5p PRKG1 3.32329949959268 8.40210501034588e-13 -4.14478022055911 0.000346396361233345 miRNATAP -0.764672975169752 1.7418280413163e-08 NA NA NA hsa-miR-21-5p PRKG1 2.65163477806992 6.72089787690756e-16 -4.14478022055911 0.000346396361233345 mirMAP -0.479858931147941 0.0146034138703031 NA NA NA hsa-miR-15b-3p PRLR 3.57530146629867 5.89922785773482e-11 -5.28037380437679 0.000876404303480571 mirMAP -0.593478840866584 0.000220832631914752 NA NA NA hsa-miR-106b-5p PRR16 2.80565545918114 1.14547999022566e-09 -4.04917337840301 2.01422228485691e-05 MirTarget;miRNATAP -0.524305599317863 5.0318880291958e-06 NA NA NA hsa-miR-106b-5p PRRG1 2.80565545918114 1.14547999022566e-09 -1.16357225512338 0.247530240845941 miRNAWalker2_validate;MirTarget;miRNATAP -0.442036450747656 0.000253336191553637 NA NA NA hsa-miR-106b-5p PRRX1 2.80565545918114 1.14547999022566e-09 -3.33510569764646 0.000414916352278086 MirTarget;miRNATAP -0.612664647732965 5.84890865892898e-08 26617763 Down regualtion of miR 106b induces epithelial mesenchymal transition but suppresses metastatic colonization by targeting Prrx1 in colorectal cancer; We identified Prrx1 was a direct target of miR-106b through using target prediction algorithms and dual-Luciferase reporter assay; Moreover Moreover we also found TGF-β1 could down-regulate miR-106b and simultaneously miR-106b also influences the expression of TGF-β1 establishing a negative feedback loop to regulate the expression of Prrx1 together colorectal cancer hsa-miR-15b-5p PRTG 3.32329949959268 8.40210501034588e-13 -4.74035707383511 5.79013562364823e-05 MirTarget -0.571329959762041 4.56715836964039e-05 NA NA NA hsa-miR-106b-5p PSD 2.80565545918114 1.14547999022566e-09 -5.74231777343125 1.61055314975589e-12 miRNATAP -0.50235461528356 5.74509411840385e-07 NA NA NA hsa-miR-15b-5p PSKH1 3.32329949959268 8.40210501034588e-13 -0.788180879660378 0.0203990517430694 MirTarget;miRNATAP -0.130230625465221 0.0011419416485677 NA NA NA hsa-miR-106b-5p PTAR1 2.80565545918114 1.14547999022566e-09 -0.0286289735840786 0.937885175925161 mirMAP -0.113145745306085 0.0103122922177133 NA NA NA hsa-miR-21-5p PTCH1 2.65163477806992 6.72089787690756e-16 -1.43647576717798 0.0689948350033021 mirMAP -0.544287680087243 3.58242516288919e-05 NA NA NA hsa-miR-21-5p PTCHD1 2.65163477806992 6.72089787690756e-16 -6.21824008232208 1.21492452024049e-05 mirMAP -0.87113192332544 0.000300212323731731 NA NA NA hsa-miR-106b-5p PTEN 2.80565545918114 1.14547999022566e-09 -0.848820542036926 0.0698463061072717 miRNAWalker2_validate;miRTarBase;miRNATAP -0.111776315347317 0.0482864718495211 24842611;26238857;26722252 MicroRNA 106b in cancer associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN;We further identified PTEN and p21 as novel direct targets of miR-106b by using target prediction algorithms and a luciferase assay; Overexpression of miR-106b reduced the expression of PTEN and p21 and increased the expression of p-AKT which is a downstream of PTEN; Restoring the expression of PTEN or p21 in stably miR-106b-overexpressed cells could rescue the effect of miR-106b on cell radioresistance; These observations illustrated that miR-106b could induce cell radioresistance by directly targeting PTEN and p21 this process was accompanied by tumour-initiating cell capacity enhancement which is universally confirmed to be associated with radioresistance;Cantharidin modulates the E2F1/MCM7 miR 106b 93/p21 PTEN signaling axis in MCF 7 breast cancer cells cell migration;drug resistance; gastric cancer;colorectal cancer;breast cancer hsa-miR-15b-3p PTEN 3.57530146629867 5.89922785773482e-11 -0.848820542036926 0.0698463061072717 mirMAP -0.101678639528678 0.0316428561568647 NA NA NA hsa-miR-106b-5p PTGER3 2.80565545918114 1.14547999022566e-09 -7.71022137673056 1.01969009459303e-10 miRNATAP -1.1058566140927 8.55681904771861e-15 NA NA NA hsa-miR-15b-5p PTGFR 3.32329949959268 8.40210501034588e-13 -6.50302143663014 1.92016408183424e-07 miRNATAP -0.567232465228045 0.000157031618754661 NA NA NA hsa-miR-21-5p PTGFR 2.65163477806992 6.72089787690756e-16 -6.50302143663014 1.92016408183424e-07 miRNAWalker2_validate -0.639542237512608 0.00277599180321486 NA NA NA hsa-miR-106b-5p PTK2B 2.80565545918114 1.14547999022566e-09 0.346445373946276 0.492450806116328 mirMAP -0.125993941508409 0.0384995977153383 NA NA NA hsa-miR-15b-3p PTPRB 3.57530146629867 5.89922785773482e-11 -3.09101383757408 1.46270121148268e-05 mirMAP -0.440735589550813 5.83820256424105e-10 NA NA NA hsa-miR-106b-5p PTPRD 2.80565545918114 1.14547999022566e-09 -5.46044460487346 0.00016227548373706 miRNATAP -0.680310482727165 0.000105801780230962 NA NA NA hsa-miR-15b-5p PTPRD 3.32329949959268 8.40210501034588e-13 -5.46044460487346 0.00016227548373706 miRNATAP -0.86253419842423 4.31520235733501e-07 NA NA NA hsa-miR-106b-5p PTPRO 2.80565545918114 1.14547999022566e-09 -1.7048647523145 0.0515032888281842 miRNATAP -0.210742376610214 0.0470370429065716 NA NA NA hsa-miR-106b-5p PTRF 2.80565545918114 1.14547999022566e-09 -3.15408357641829 1.9784743552567e-05 mirMAP -0.249092726144721 0.00582394720688903 NA NA NA hsa-miR-21-5p PTX3 2.65163477806992 6.72089787690756e-16 -3.81681259494014 0.00481153739370009 miRNAWalker2_validate -0.76855516104286 0.000739646725779168 NA NA NA hsa-miR-21-3p PYGO1 3.50297439576639 6.39946844099206e-10 -2.44710213372309 0.0639646847724574 mirMAP -0.376959970229135 0.00347175054943963 NA NA NA hsa-miR-15b-5p RAB11FIP2 3.32329949959268 8.40210501034588e-13 -2.40383301883775 2.3729959132263e-11 MirTarget;miRNATAP -0.181666257897228 3.00273831670653e-05 NA NA NA hsa-miR-21-5p RAB11FIP2 2.65163477806992 6.72089787690756e-16 -2.40383301883775 2.3729959132263e-11 miRNAWalker2_validate -0.31451482716201 2.88831181698551e-07 NA NA NA hsa-miR-106b-5p RAB12 2.80565545918114 1.14547999022566e-09 -0.66215570133917 0.09118044326922 miRNATAP -0.107070521365396 0.0234743284142118 NA NA NA hsa-miR-106b-5p RAB27A 2.80565545918114 1.14547999022566e-09 -0.0690192057185266 0.860681907257594 mirMAP -0.124546357971649 0.00836858210238279 NA NA NA hsa-miR-15b-3p RAB30 3.57530146629867 5.89922785773482e-11 -1.03892493142443 0.0893122492342257 mirMAP -0.131126782682456 0.0340342479018789 NA NA NA hsa-miR-15b-5p RAB37 3.32329949959268 8.40210501034588e-13 -0.647533124239443 0.389030970818419 mirMAP -0.22376280579454 0.0118714079706813 NA NA NA hsa-miR-106b-5p RAB5B 2.80565545918114 1.14547999022566e-09 -0.621411154842082 0.00442298316012775 miRNATAP -0.106665562810097 3.86966759234361e-05 NA NA NA hsa-miR-21-5p RAB6A 2.65163477806992 6.72089787690756e-16 -0.164410898799484 0.618024808019916 miRNAWalker2_validate;miRNATAP -0.126878791015417 0.0212172928475651 NA NA NA hsa-miR-21-5p RAB6C 2.65163477806992 6.72089787690756e-16 -1.04097362986983 0.0224221050761607 miRNAWalker2_validate -0.422205000085532 1.87103306636785e-08 NA NA NA hsa-miR-106b-5p RAB8B 2.80565545918114 1.14547999022566e-09 -1.19782846334847 0.00146439299102655 miRNATAP -0.13037805824536 0.00418682678124802 NA NA NA hsa-miR-106b-5p RABGAP1L 2.80565545918114 1.14547999022566e-09 -0.590976755070293 0.12030069636445 mirMAP -0.119076439699846 0.00928214527533343 NA NA NA hsa-miR-125a-5p RACGAP1 -1.32352790615388 0.00714301627309467 3.58899122370829 2.26548917621428e-26 miRanda -0.1997555578726 1.86966142257946e-06 NA NA NA hsa-miR-106b-5p RAP2C 2.80565545918114 1.14547999022566e-09 -0.963123560669377 0.0108848030318949 MirTarget;miRNATAP -0.165238091962027 0.000274771741514003 NA NA NA hsa-miR-15b-5p RAP2C 3.32329949959268 8.40210501034588e-13 -0.963123560669377 0.0108848030318949 MirTarget;miRNATAP -0.136004842131881 0.00233986199307681 NA NA NA hsa-miR-15b-5p RAPGEF1 3.32329949959268 8.40210501034588e-13 -0.560370378742237 0.0772885691467389 miRNATAP -0.102049711948545 0.0062947001454453 NA NA NA hsa-miR-15b-5p RAPGEF2 3.32329949959268 8.40210501034588e-13 -0.848933745143619 0.030186097225232 miRNATAP -0.136586353763295 0.003139307182147 NA NA NA hsa-miR-106b-5p RAPGEFL1 2.80565545918114 1.14547999022566e-09 3.81096361376763 6.28933645623364e-05 miRNATAP -0.266193552219878 0.0222781236053573 NA NA NA hsa-miR-106b-5p RARB 2.80565545918114 1.14547999022566e-09 -1.23106790781811 0.2496278765764 miRNATAP -0.540176799290085 2.41915984245989e-05 NA NA NA hsa-miR-99a-5p RARS -2.72139054000803 0.00621971944534118 0.419528183347368 0.113636476928365 miRNAWalker2_validate -0.10312555402285 7.05593159067932e-13 NA NA NA hsa-miR-15b-5p RASA4 3.32329949959268 8.40210501034588e-13 -3.32083384454286 9.20729082060652e-09 mirMAP -0.177466651546412 0.0113875059348426 NA NA NA hsa-miR-106b-5p RASGRF2 2.80565545918114 1.14547999022566e-09 -2.9068173867099 5.9508387011546e-05 MirTarget -0.425105775462409 1.08336004178415e-06 NA NA NA hsa-miR-106b-5p RASL11B 2.80565545918114 1.14547999022566e-09 -2.71123020565522 0.00371289531238615 MirTarget;miRNATAP -0.237410065272185 0.0367124117233548 NA NA NA hsa-miR-15b-5p RASL12 3.32329949959268 8.40210501034588e-13 -5.24291332615962 1.84272778907522e-11 miRNATAP -0.470158767507815 6.10705097918816e-07 NA NA NA hsa-miR-106b-5p RASSF2 2.80565545918114 1.14547999022566e-09 -1.84693151665047 0.00526283577521879 MirTarget;miRNATAP -0.290754900776342 0.000269850011562453 NA NA NA hsa-miR-15b-5p RASSF2 3.32329949959268 8.40210501034588e-13 -1.84693151665047 0.00526283577521879 MirTarget -0.209613913181874 0.00771586955197143 NA NA NA hsa-miR-15b-3p RASSF4 3.57530146629867 5.89922785773482e-11 0.339946166144012 0.612664991108858 mirMAP -0.143463297707842 0.0343687060914967 NA NA NA hsa-miR-15b-3p RASSF8 3.57530146629867 5.89922785773482e-11 -3.1188523283351 0.000151262443971379 mirMAP -0.236937545165028 0.00473305777199923 NA NA NA hsa-miR-106b-5p RB1 2.80565545918114 1.14547999022566e-09 0.829018740404748 0.105390264359777 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.16042317732856 0.00937327175309839 NA NA NA hsa-miR-106b-5p RBL2 2.80565545918114 1.14547999022566e-09 -0.290362042828854 0.459600981952894 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.152134757968797 0.00122146155020016 NA NA NA hsa-miR-106b-5p RBM43 2.80565545918114 1.14547999022566e-09 -1.19503267308595 0.0197859558419652 mirMAP -0.206736681758668 0.00081635095207556 NA NA NA hsa-miR-106b-5p RBMS1 2.80565545918114 1.14547999022566e-09 -1.25516158530751 0.00212730095365255 miRNATAP -0.136558931642869 0.00574578306536734 NA NA NA hsa-miR-21-5p RBPJ 2.65163477806992 6.72089787690756e-16 -1.04357398831524 0.00423390245598247 MirTarget;miRNATAP -0.148411841643255 0.0156077371658711 NA NA NA hsa-miR-21-3p RCBTB1 3.50297439576639 6.39946844099206e-10 -0.397047308455567 0.413626298872103 MirTarget -0.16190465757427 0.000582177518004166 NA NA NA hsa-miR-21-5p RDH11 2.65163477806992 6.72089787690756e-16 0.00197685238107503 0.995289908579342 miRNAWalker2_validate -0.1550093487824 0.0054867649734336 NA NA NA hsa-miR-15b-5p RECK 3.32329949959268 8.40210501034588e-13 -4.28782478538832 5.46316347444686e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.489210935831811 1.91019296285358e-07 NA NA NA hsa-miR-21-5p RECK 2.65163477806992 6.72089787690756e-16 -4.28782478538832 5.46316347444686e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.271840383510751 0.0452346712011242 19730150;20480266;22642976;18794849;25720799 Protein levels of tumor suppressor targets of the miRNAs were increased by antisense to miR-21 PTEN and RECK and miR-221 p27;Furthermore we identified that RECK reversion-inducing-cysteine-rich protein with kazal motifs a tumor suppressor gene was a direct target of miR-21; Our results suggest that miR-21 expression has a key role in regulating cellular processes in osteosarcoma likely through regulating RECK and may serve as a therapeutic target;miR 21 may acts as an oncomir by targeting RECK a matrix metalloproteinase regulator in prostate cancer; The micro RNA miRNA mir-21 has been shown to regulate invasiveness in cancer through translational repression of the Metaloproteinase MMP inhibitor RECK; Our aim is to investigate the levels of expression of RECK and miR-21 in PCa comparing with classical prognostic factors and disease outcome and also test if RECK is a target of miR-21 in in vitro study using PCa cell line; To determine if RECK is a target of miR-21 in prostate cancer we performed an in vitro assay with PCa cell line DU-145 transfected with pre-miR-21 and anti-miR-21; To determine miR-21 and RECK expression levels in PCa samples we performed quantitative real-time polymerase chain reaction qRT-PCR; From men who presented the second profile miR-21 overexpression and RECK underexpression 91.7% were staged pT3; Our results demonstrate RECK as a target of miR-21; We believe that miR-21 may be important in PCa progression through its regulation of RECK a known regulator of tumor cell invasion;Finally we showed that RECK a known tumor suppressor in gastric cancer is a bona fide target of miR-21; Taken together miR-21 may be important in the initiation and progression of gastric cancers as an oncomiR likely through regulating RECK; Our findings suggest a potential regulatory pathway in which H pylori infection upregulates expression of miR-21 which in turn downregulates RECK and then leads to the development of gastric cancer;We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression ;;staging;progression;progression;metastasis;progression pancreatic cancer;sarcoma;prostate cancer;gastric cancer;liver cancer hsa-miR-21-3p REEP1 3.50297439576639 6.39946844099206e-10 -3.42812600753263 0.00234602913694785 MirTarget -0.362059306193603 0.00103069050420878 NA NA NA hsa-miR-15b-5p RELN 3.32329949959268 8.40210501034588e-13 -4.56675081618191 0.00128745672091879 MirTarget;miRNATAP -0.492629692327408 0.00356060731431605 NA NA NA hsa-miR-106b-5p RERE 2.80565545918114 1.14547999022566e-09 -1.87900769034776 3.25524973250962e-07 mirMAP -0.103391781901408 0.0220578721235002 NA NA NA hsa-miR-15b-3p RERG 3.57530146629867 5.89922785773482e-11 -5.92571903501595 4.19260816241464e-08 miRNATAP -0.563754775798887 2.93415433774535e-07 NA NA NA hsa-miR-21-5p REV3L 2.65163477806992 6.72089787690756e-16 -2.45829622399505 1.0769322076255e-06 miRNAWalker2_validate -0.381769727488417 7.23631600710186e-06 NA NA NA hsa-miR-106b-5p RGL1 2.80565545918114 1.14547999022566e-09 -2.1168474173652 0.000359383480276991 MirTarget;miRNATAP -0.175543754690136 0.015090126817996 NA NA NA hsa-miR-106b-5p RGMA 2.80565545918114 1.14547999022566e-09 -2.0431677178752 0.0628046174629442 miRNATAP -0.332567813915233 0.012306090250388 NA NA NA hsa-miR-15b-3p RGS5 3.57530146629867 5.89922785773482e-11 -3.13321263597217 3.01852167943865e-05 mirMAP -0.426140743278814 1.47141411811054e-08 NA NA NA hsa-miR-21-3p RHBDD1 3.50297439576639 6.39946844099206e-10 -0.623225243399799 0.0726636859893767 mirMAP -0.110220226354924 0.00105684749800738 NA NA NA hsa-miR-21-5p RHOQ 2.65163477806992 6.72089787690756e-16 -1.63682590926236 4.60509064261765e-05 miRNAWalker2_validate -0.222383142313771 0.00104334755088047 NA NA NA hsa-miR-15b-3p RICTOR 3.57530146629867 5.89922785773482e-11 -0.245151891102313 0.522334062834239 mirMAP -0.11740177171332 0.00224919531203597 NA NA NA hsa-miR-21-5p RMND5A 2.65163477806992 6.72089787690756e-16 0.196874990139229 0.498606848633289 miRNAWalker2_validate;MirTarget;miRNATAP -0.116938883344294 0.0158845531595362 NA NA NA hsa-miR-106b-5p RNASEL 2.80565545918114 1.14547999022566e-09 -0.00231728523625208 0.996433462391688 MirTarget -0.270675912014521 1.17450245937137e-05 NA NA NA hsa-miR-21-5p RNF103 2.65163477806992 6.72089787690756e-16 -1.43753069876742 8.86415904210193e-05 MirTarget -0.14927209108122 0.0161646670183468 NA NA NA hsa-miR-21-5p RNF11 2.65163477806992 6.72089787690756e-16 -0.847612615043476 0.0124662426019983 miRNAWalker2_validate -0.120311704189045 0.0347773868438718 NA NA NA hsa-miR-15b-5p RNF125 3.32329949959268 8.40210501034588e-13 -2.01893904580971 0.000742432495008456 miRNATAP -0.228273402426173 0.00133285951776046 NA NA NA hsa-miR-21-3p RNF144A 3.50297439576639 6.39946844099206e-10 -2.22361638200378 0.000139521556917527 mirMAP -0.306271912491005 5.80638984252503e-08 NA NA NA hsa-miR-21-3p RNF146 3.50297439576639 6.39946844099206e-10 -1.29162769455589 3.33488568514936e-06 MirTarget -0.130985560633429 1.19171210131646e-06 NA NA NA hsa-miR-15b-3p RNF169 3.57530146629867 5.89922785773482e-11 0.0503986282261613 0.92782963105779 mirMAP -0.116261514164529 0.0383956853632182 NA NA NA hsa-miR-106b-5p RNF213 2.80565545918114 1.14547999022566e-09 1.56015463594484 0.00388824200130438 mirMAP -0.136916243917762 0.0369370454701 NA NA NA hsa-miR-15b-5p ROR1 3.32329949959268 8.40210501034588e-13 -3.09678254019376 0.0070930664769625 miRNATAP -0.285360657949757 0.0374151970682117 NA NA NA hsa-miR-21-5p ROR1 2.65163477806992 6.72089787690756e-16 -3.09678254019376 0.0070930664769625 miRNATAP -0.518937323446099 0.00748455613354674 NA NA NA hsa-miR-106b-5p RORA 2.80565545918114 1.14547999022566e-09 -1.24412204731139 0.114009602795648 miRNAWalker2_validate;MirTarget;miRNATAP -0.328961560274129 0.000510801803215018 NA NA NA hsa-miR-15b-5p RORA 3.32329949959268 8.40210501034588e-13 -1.24412204731139 0.114009602795648 MirTarget;miRNATAP -0.207454474667774 0.0263131379215873 NA NA NA hsa-miR-21-3p RORA 3.50297439576639 6.39946844099206e-10 -1.24412204731139 0.114009602795648 mirMAP -0.208798132828436 0.00656795117598209 NA NA NA hsa-miR-99a-5p RPL36A -2.72139054000803 0.00621971944534118 1.71065430121314 0.00720276823930281 miRNAWalker2_validate -0.159307070950916 8.58872032473229e-06 NA NA NA hsa-miR-21-3p RPS6KA2 3.50297439576639 6.39946844099206e-10 -2.65030014005572 0.000604235142902453 MirTarget -0.163609468058562 0.0316623495188542 NA NA NA hsa-miR-15b-5p RPS6KA6 3.32329949959268 8.40210501034588e-13 -4.01589146007697 0.00361422176832556 MirTarget -0.630779583352634 0.000112057448754317 NA NA NA hsa-miR-21-5p RPS7 2.65163477806992 6.72089787690756e-16 -0.192858147463898 0.626167485999006 miRNAWalker2_validate;miRTarBase -0.152940142589525 0.0209715417946672 NA NA NA hsa-miR-21-3p RRAGB 3.50297439576639 6.39946844099206e-10 -1.32370782273036 0.00123450772806318 MirTarget -0.129691656091277 0.00119256773593983 NA NA NA hsa-miR-21-5p RSBN1 2.65163477806992 6.72089787690756e-16 -0.854878826262855 0.0160043309694689 miRNATAP -0.209126371735897 0.000416269477720493 NA NA NA hsa-miR-15b-5p RSPO3 3.32329949959268 8.40210501034588e-13 -6.16736458384708 1.06567414591182e-05 MirTarget -0.849226529318684 2.9573838689247e-07 NA NA NA hsa-miR-15b-5p RUNDC3B 3.32329949959268 8.40210501034588e-13 -4.91667656639446 1.92145647334424e-09 MirTarget -0.467561207269934 2.00978987129334e-06 NA NA NA hsa-miR-106b-5p RUNX1T1 2.80565545918114 1.14547999022566e-09 -4.6090415326702 3.8910513010392e-05 miRNAWalker2_validate -0.792419567573294 3.24520529586357e-09 NA NA NA hsa-miR-15b-3p RUNX1T1 3.57530146629867 5.89922785773482e-11 -4.6090415326702 3.8910513010392e-05 mirMAP;miRNATAP -0.874954125146482 1.3071119421107e-15 NA NA NA hsa-miR-15b-5p RUNX1T1 3.32329949959268 8.40210501034588e-13 -4.6090415326702 3.8910513010392e-05 miRNATAP -0.891011640911484 7.36477958179822e-12 NA NA NA hsa-miR-106b-5p RUNX2 2.80565545918114 1.14547999022566e-09 0.934699578619514 0.1928528894044 mirMAP -0.302896417112355 0.000443173412616767 NA NA NA hsa-miR-15b-3p RYR2 3.57530146629867 5.89922785773482e-11 -3.32245795273437 0.00330096979617608 mirMAP -0.474480767351325 3.09602219830998e-05 NA NA NA hsa-miR-106b-5p S1PR1 2.80565545918114 1.14547999022566e-09 -4.01418630144884 5.44196300572006e-10 MirTarget;miRNATAP -0.486822052080037 5.14837730515171e-10 NA NA NA hsa-miR-21-5p SACM1L 2.65163477806992 6.72089787690756e-16 -0.477218671114569 0.0933675955085362 miRNAWalker2_validate -0.12959204029696 0.00627150531472577 NA NA NA hsa-miR-106b-5p SALL1 2.80565545918114 1.14547999022566e-09 -4.47159449003311 0.00029519349507519 MirTarget;miRNATAP -0.631621321168755 2.3118647222081e-05 NA NA NA hsa-miR-15b-5p SALL1 3.32329949959268 8.40210501034588e-13 -4.47159449003311 0.00029519349507519 MirTarget;miRNATAP -0.667110364616245 4.90367299734403e-06 NA NA NA hsa-miR-106b-3p SALL2 2.57689304590494 1.04870442173494e-07 -2.8786702594338 0.0061535708889588 miRNAWalker2_validate -0.277102293001234 0.0232516321125735 NA NA NA hsa-miR-15b-5p SAMD4A 3.32329949959268 8.40210501034588e-13 -3.02274280716444 5.18320042685348e-05 MirTarget -0.380213178433542 1.78085734673387e-05 NA NA NA hsa-miR-106b-5p SAMD5 2.80565545918114 1.14547999022566e-09 -3.52010966528043 0.00165842062860753 mirMAP -0.288435149479585 0.0343289704758176 NA NA NA hsa-miR-21-5p SAMD5 2.65163477806992 6.72089787690756e-16 -3.52010966528043 0.00165842062860753 miRNAWalker2_validate -0.389132524011839 0.0401795439152209 NA NA NA hsa-miR-106b-5p SAMHD1 2.80565545918114 1.14547999022566e-09 1.22240252141231 0.0841510171544413 mirMAP -0.239306688139475 0.00508434874572392 NA NA NA hsa-miR-106b-5p SASH1 2.80565545918114 1.14547999022566e-09 -1.00561553511658 0.0624707747380935 MirTarget;miRNATAP -0.30381678870723 2.34266457290166e-06 NA NA NA hsa-miR-15b-3p SATB1 3.57530146629867 5.89922785773482e-11 -1.40849219503093 0.100619172764777 mirMAP -0.324878334423022 0.000163139751915406 NA NA NA hsa-miR-21-3p SBNO1 3.50297439576639 6.39946844099206e-10 1.43133210042125 0.0991240752574181 mirMAP -0.170209028801483 0.0451440180492277 NA NA NA hsa-miR-21-3p SCAI 3.50297439576639 6.39946844099206e-10 -0.222244430635824 0.522964020858186 MirTarget -0.140987647745019 2.50778710177624e-05 NA NA NA hsa-miR-21-3p SCAMP1 3.50297439576639 6.39946844099206e-10 -0.605834463987607 0.0506290893974263 MirTarget -0.111402248947396 0.000198424564050331 NA NA NA hsa-miR-21-5p SCML2 2.65163477806992 6.72089787690756e-16 -0.577003833519651 0.487499828084718 MirTarget;miRNATAP -0.660184272599965 1.60084509365113e-06 NA NA NA hsa-miR-106b-5p SCN1B 2.80565545918114 1.14547999022566e-09 -2.81702368890277 0.000395392249103292 mirMAP -0.248552833560897 0.0102552240937094 NA NA NA hsa-miR-15b-5p SCN2A 3.32329949959268 8.40210501034588e-13 -1.67698295494461 0.364163960938173 MirTarget -0.506521133899583 0.0207565431281819 NA NA NA hsa-miR-106b-5p SCN2B 2.80565545918114 1.14547999022566e-09 -6.08346532190498 3.4500499981209e-07 MirTarget -0.64698798094458 8.65535469829602e-06 NA NA NA hsa-miR-15b-5p SCN2B 3.32329949959268 8.40210501034588e-13 -6.08346532190498 3.4500499981209e-07 mirMAP -0.7228639682515 3.53048553711536e-07 NA NA NA hsa-miR-106b-5p SCN3A 2.80565545918114 1.14547999022566e-09 -3.01591468571821 0.00670485854462323 MirTarget -0.512111490743886 0.000134044806824845 NA NA NA hsa-miR-15b-3p SCN3A 3.57530146629867 5.89922785773482e-11 -3.01591468571821 0.00670485854462323 mirMAP -0.658894236599973 2.30466956962416e-09 NA NA NA hsa-miR-15b-5p SCN3A 3.32329949959268 8.40210501034588e-13 -3.01591468571821 0.00670485854462323 MirTarget -0.659635204707347 4.18455888811649e-07 NA NA NA hsa-miR-106b-5p SCN3B 2.80565545918114 1.14547999022566e-09 -3.06176127627563 0.00852381009637453 mirMAP -0.674546906877173 1.27459805979066e-06 NA NA NA hsa-miR-15b-5p SCN4B 3.32329949959268 8.40210501034588e-13 -4.17296390827586 3.10514975792868e-05 miRNATAP -0.397138923969091 0.000909769935843236 NA NA NA hsa-miR-21-3p SDC2 3.50297439576639 6.39946844099206e-10 -3.48496703171104 0.000178061797352628 MirTarget -0.50837089083717 1.50690806653497e-08 NA NA NA hsa-miR-106b-5p SDCBP 2.80565545918114 1.14547999022566e-09 -1.20749407833929 0.000685659867755695 miRNATAP -0.11838981602054 0.005963031797362 NA NA NA hsa-miR-21-5p SEC14L5 2.65163477806992 6.72089787690756e-16 -1.21482779770722 0.177107576013509 mirMAP -0.607145722188163 5.17221423643809e-05 NA NA NA hsa-miR-21-5p SEC62 2.65163477806992 6.72089787690756e-16 -0.82566540442722 0.0118361956846936 mirMAP -0.171940289641161 0.00172198464982555 NA NA NA hsa-miR-15b-3p SEMA3C 3.57530146629867 5.89922785773482e-11 -1.73161285045103 0.0200288038927353 MirTarget -0.350565669238059 2.49039046197843e-06 NA NA NA hsa-miR-15b-5p SEMA3D 3.32329949959268 8.40210501034588e-13 -4.15035983593079 0.00509507453017577 MirTarget;miRNATAP -0.349303868412535 0.0482203980487868 NA NA NA hsa-miR-106b-5p SEMA4B 2.80565545918114 1.14547999022566e-09 2.49234388986505 9.2826040446808e-05 MirTarget -0.160240902927903 0.0397543691742629 NA NA NA hsa-miR-15b-3p SEMA5A 3.57530146629867 5.89922785773482e-11 -2.54162658339127 0.0125315674439115 mirMAP -0.534029644434997 1.41467365282273e-07 NA NA NA hsa-miR-15b-5p SEMA5A 3.32329949959268 8.40210501034588e-13 -2.54162658339127 0.0125315674439115 mirMAP -0.453767831183143 0.000161205793680836 NA NA NA hsa-miR-21-3p SEMA6A 3.50297439576639 6.39946844099206e-10 -2.29385393167564 0.0649090465042581 MirTarget -0.485305404471809 5.69923067600246e-05 NA NA NA hsa-miR-106b-5p SEMA7A 2.80565545918114 1.14547999022566e-09 1.25356315133488 0.0777822421960975 MirTarget;miRNATAP -0.191780587279304 0.0257236651530393 NA NA NA hsa-miR-15b-5p SEMA7A 3.32329949959268 8.40210501034588e-13 1.25356315133488 0.0777822421960975 mirMAP -0.192150653336061 0.0226716604303168 NA NA NA hsa-miR-15b-3p SEPSECS 3.57530146629867 5.89922785773482e-11 -0.0594230577150539 0.87153067911955 mirMAP -0.10433718566775 0.00464684841950501 NA NA NA hsa-miR-106b-5p SEPT11 2.80565545918114 1.14547999022566e-09 -0.562439194179026 0.196692162784416 mirMAP -0.117238059712903 0.0256058053589065 NA NA NA hsa-miR-21-5p SERAC1 2.65163477806992 6.72089787690756e-16 -0.409040957060423 0.341849206128473 miRNAWalker2_validate -0.15611844189751 0.0304518505750852 NA NA NA hsa-miR-99a-5p SERPINE1 -2.72139054000803 0.00621971944534118 0.617692230647947 0.572474588134307 miRNAWalker2_validate -0.208155381578803 0.000740541769690584 NA NA NA hsa-miR-21-5p SERPINI1 2.65163477806992 6.72089787690756e-16 -1.67075782450042 0.0357027927024642 miRNAWalker2_validate -0.46209152898316 0.000526501044863073 22464652 MicroRNA 21 inhibits Serpini1 a gene with novel tumour suppressive effects in gastric cancer; Molecular techniques include microRNA microarrays cDNA microarrays qRT-PCR for miR and mRNA expression transfection of MKN28 with miR-21 inhibitor or Serpini1 followed by Western blotting cell cycle analysis by flow cytometry and luciferase reporter assay; This search identified Serpini1 as a putative miR-21 target; Luciferase assays demonstrated direct interaction between miR-21 and Serpini1 3'UTR miR-21 and Serpini1 expression levels were inversely correlated in a subgroup of gastric cancers suggesting a regulatory mechanism that included both of these molecules; Taken together these data suggest that in a subgroup of gastric cancers miR-21 is upregulated inducing downregulation of Serpini1 which in turn releases the G1-S transition checkpoint with the end result being increased tumour growth gastric cancer hsa-miR-15b-5p SESN1 3.32329949959268 8.40210501034588e-13 -1.78011230018704 6.12493041347409e-05 MirTarget;miRNATAP -0.216447875967851 3.9110601969145e-05 NA NA NA hsa-miR-106b-5p SETD7 2.80565545918114 1.14547999022566e-09 -1.43322977203362 0.00158498784933718 mirMAP -0.143886645414768 0.00890325793603945 NA NA NA hsa-miR-15b-5p SGCA 3.32329949959268 8.40210501034588e-13 -7.02243640299791 7.72874213498076e-11 MirTarget -0.79720524362673 5.94917904022001e-10 NA NA NA hsa-miR-21-5p SGCB 2.65163477806992 6.72089787690756e-16 -2.01454769878579 0.000173106453387292 miRNAWalker2_validate -0.397230826099528 9.99796069408326e-06 NA NA NA hsa-miR-106b-5p SGCD 2.80565545918114 1.14547999022566e-09 -4.54262936780335 0.000169922663050445 mirMAP -0.700526030964996 1.45945964872867e-06 NA NA NA hsa-miR-15b-5p SGCD 3.32329949959268 8.40210501034588e-13 -4.54262936780335 0.000169922663050445 miRNATAP -0.528898941754897 0.000234001524213351 NA NA NA hsa-miR-21-3p SGCD 3.50297439576639 6.39946844099206e-10 -4.54262936780335 0.000169922663050445 mirMAP -0.70817699994157 1.12370757115623e-09 NA NA NA hsa-miR-15b-3p SGIP1 3.57530146629867 5.89922785773482e-11 -2.18475545881069 0.00755388449061642 mirMAP -0.535160855290852 2.9318075819247e-11 NA NA NA hsa-miR-21-5p SGTB 2.65163477806992 6.72089787690756e-16 -1.67670607214554 2.7309023271491e-05 mirMAP -0.16492566778664 0.0150105533781489 NA NA NA hsa-miR-106b-5p SH2B3 2.80565545918114 1.14547999022566e-09 -1.47178277178044 0.00115664713257855 MirTarget -0.197911009962818 0.000293522804578337 NA NA NA hsa-miR-21-5p SH3BGRL2 2.65163477806992 6.72089787690756e-16 -2.07264686502094 0.0490585863284241 mirMAP -0.496177131152308 0.00507349418120322 NA NA NA hsa-miR-15b-5p SH3BP2 3.32329949959268 8.40210501034588e-13 0.869196065277001 0.0322975614217993 MirTarget -0.108779960521896 0.0237034107315004 NA NA NA hsa-miR-106b-5p SH3PXD2A 2.80565545918114 1.14547999022566e-09 -0.789218360034056 0.0781848118396428 MirTarget;miRNATAP -0.169774623842181 0.00162687359696445 NA NA NA hsa-miR-15b-5p SH3PXD2B 3.32329949959268 8.40210501034588e-13 -0.936740579544854 0.050176794226959 mirMAP -0.11533175199582 0.0420527410942705 NA NA NA hsa-miR-15b-5p SHE 3.32329949959268 8.40210501034588e-13 -3.680365549955 0.000191992406750442 mirMAP -0.27837973177016 0.0184553134385183 NA NA NA hsa-miR-106b-5p SHOC2 2.80565545918114 1.14547999022566e-09 -0.481464618233717 0.0618789686319316 MirTarget;miRNATAP -0.107646393346148 0.000462237027508004 NA NA NA hsa-miR-15b-3p SHPRH 3.57530146629867 5.89922785773482e-11 -0.0649717605136879 0.94155617898992 MirTarget -0.196565181744938 0.0280894633251372 NA NA NA hsa-miR-21-3p SHPRH 3.50297439576639 6.39946844099206e-10 -0.0649717605136879 0.94155617898992 MirTarget -0.278882631357204 0.00120094542084717 NA NA NA hsa-miR-106b-5p SHROOM4 2.80565545918114 1.14547999022566e-09 -2.05440419969342 0.0148757283652817 mirMAP -0.39446308173163 0.000101593290892102 NA NA NA hsa-miR-15b-5p SHROOM4 3.32329949959268 8.40210501034588e-13 -2.05440419969342 0.0148757283652817 miRNATAP -0.368658601808827 0.000216001900954166 NA NA NA hsa-miR-15b-5p SIDT2 3.32329949959268 8.40210501034588e-13 -1.83969244123932 3.72275181005798e-07 miRNATAP -0.290223310758478 5.50551760806984e-12 NA NA NA hsa-miR-15b-3p SKI 3.57530146629867 5.89922785773482e-11 -1.15284648081887 0.00256963187587249 mirMAP -0.174957184636122 4.79840370315297e-06 NA NA NA hsa-miR-15b-5p SKI 3.32329949959268 8.40210501034588e-13 -1.15284648081887 0.00256963187587249 MirTarget;miRNATAP -0.115814230190988 0.0107078628043426 NA NA NA hsa-miR-342-3p SLC15A1 1.31107714473009 0.0207211910724662 0.705365276407446 0.669391047838896 miRanda -0.694592749612796 2.26994690427712e-05 NA NA NA hsa-miR-590-3p SLC15A1 2.35429565068338 2.79601879608564e-06 0.705365276407446 0.669391047838896 miRanda -0.364216184405025 0.0490539446366066 NA NA NA hsa-miR-15b-5p SLC15A4 3.32329949959268 8.40210501034588e-13 -0.685684526102496 0.0450218546931546 MirTarget -0.128876726491397 0.00136948260546759 NA NA NA hsa-miR-106b-5p SLC16A6 2.80565545918114 1.14547999022566e-09 1.58147075645052 0.0729879579748508 MirTarget;miRNATAP -0.219137269778789 0.0402564609746841 NA NA NA hsa-miR-21-5p SLC17A5 2.65163477806992 6.72089787690756e-16 -0.933515763507666 0.0382547987827557 miRNAWalker2_validate -0.204786132454697 0.00674586969035043 NA NA NA hsa-miR-21-3p SLC1A2 3.50297439576639 6.39946844099206e-10 -1.36619804746756 0.219059854633584 mirMAP -0.559086419504248 1.61029944810577e-07 NA NA NA hsa-miR-15b-3p SLC22A15 3.57530146629867 5.89922785773482e-11 1.06029563295729 0.168397066489504 mirMAP -0.205651300516553 0.00813566426549732 NA NA NA hsa-miR-15b-5p SLC24A3 3.32329949959268 8.40210501034588e-13 -4.24726943656412 0.00045106557149803 miRNATAP -0.504933988229813 0.000453462364613652 NA NA NA hsa-miR-21-5p SLC26A2 2.65163477806992 6.72089787690756e-16 -0.903907649923581 0.165595054325195 miRNAWalker2_validate;mirMAP -0.228654295838815 0.0370185646027478 NA NA NA hsa-miR-106b-5p SLC2A3 2.80565545918114 1.14547999022566e-09 -1.81608639562832 0.0147764966199509 mirMAP -0.184580508441316 0.0411747883399765 NA NA NA hsa-miR-15b-5p SLC2A3 3.32329949959268 8.40210501034588e-13 -1.81608639562832 0.0147764966199509 miRNATAP -0.231319136782462 0.00893176859119204 NA NA NA hsa-miR-106b-5p SLC2A4 2.80565545918114 1.14547999022566e-09 -4.7710170541568 2.08003307764473e-07 miRNATAP -0.263016645611148 0.0203167361849308 NA NA NA hsa-miR-15b-5p SLC39A13 3.32329949959268 8.40210501034588e-13 -1.66286689271519 1.92481845077218e-05 mirMAP -0.151349967870936 0.00110073091245747 NA NA NA hsa-miR-106b-5p SLC40A1 2.80565545918114 1.14547999022566e-09 -2.61288792968051 0.00821222607930735 miRNATAP -0.297043836034225 0.0132577288962813 NA NA NA hsa-miR-106b-5p SLC46A3 2.80565545918114 1.14547999022566e-09 -1.36326120201467 0.0804860029652149 MirTarget -0.450949974930392 1.23107930370536e-06 NA NA NA hsa-miR-106b-5p SLFN5 2.80565545918114 1.14547999022566e-09 0.426735607991628 0.518108143193961 mirMAP -0.183408259041269 0.0213308155421875 NA NA NA hsa-miR-106b-5p SLITRK2 2.80565545918114 1.14547999022566e-09 -4.46262104965477 0.000225056074200622 MirTarget -0.498343921709858 0.000695272642558607 NA NA NA hsa-miR-106b-5p SLITRK4 2.80565545918114 1.14547999022566e-09 -3.01623362091086 0.0556329502638095 miRNATAP -0.733577337194881 0.000107456148435529 NA NA NA hsa-miR-15b-3p SLITRK4 3.57530146629867 5.89922785773482e-11 -3.01623362091086 0.0556329502638095 mirMAP -0.869453591506081 2.71805494756324e-08 NA NA NA hsa-miR-106b-5p SLMAP 2.80565545918114 1.14547999022566e-09 -1.87796144729804 3.28223296827071e-07 mirMAP -0.175699681285374 8.72035600850268e-05 NA NA NA hsa-miR-21-3p SMAD4 3.50297439576639 6.39946844099206e-10 -1.1222647897474 0.00638923144286853 mirMAP -0.112729088104479 0.00502861854832022 NA NA NA hsa-miR-106b-5p SMAD7 2.80565545918114 1.14547999022566e-09 -0.95880969992043 0.0366992059513236 miRNATAP -0.153866006306842 0.00543882440686572 27619676;25286029;22286770 MiR 106b promotes migration and invasion through enhancing EMT via downregulation of Smad 7 in Kazakh's esophageal squamous cell carcinoma; To understand the regulation between miR-106b and Smad 7 qRT-PCR and western blot were performed; Smad 7 was confirmed as a downstream target of miR-106b in our experimental setting; Our results indicated that miR-106b can promote migration and invasion of ESCC cells through enhancing EMT process via downregulation of Smad 7 suggesting that miR-106b can be a potential molecular phenotype in ESCC metastases;Smad7 which inhibits transforming growth factor-β TGF-β/Smad signaling as a target of the miR-106b family was downregulated in CD44+ cells;The miR 106b 25 cluster targets Smad7 activates TGF β signaling and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer metastasis;; esophageal cancer;gastric cancer;breast cancer hsa-miR-15b-5p SMAD7 3.32329949959268 8.40210501034588e-13 -0.95880969992043 0.0366992059513236 miRNAWalker2_validate;MirTarget;miRNATAP -0.12276933574354 0.0240265474350386 NA NA NA hsa-miR-106b-5p SMOC2 2.80565545918114 1.14547999022566e-09 -6.42424873467302 1.34048949738702e-09 miRNATAP -0.73041251070928 1.47648670113768e-08 NA NA NA hsa-miR-21-5p SNED1 2.65163477806992 6.72089787690756e-16 -3.58613528222197 1.68014709826689e-06 miRNATAP -0.262381230173583 0.040634849595494 NA NA NA hsa-miR-15b-5p SNRK 3.32329949959268 8.40210501034588e-13 -1.24751941303867 0.000191494181615894 MirTarget;miRNATAP -0.163230851963526 3.51222515580463e-05 NA NA NA hsa-miR-21-3p SNTB1 3.50297439576639 6.39946844099206e-10 -0.868927807592812 0.316425657480102 mirMAP -0.358403064487645 1.9001874416882e-05 NA NA NA hsa-miR-192-5p SNX10 1.77716187978541 0.113485496183047 0.371421666812941 0.615603195465232 miRNAWalker2_validate -0.115701248373661 0.00180883043391197 NA NA NA hsa-miR-429 SNX10 6.39965293994036 1.96920201593608e-18 0.371421666812941 0.615603195465232 miRanda -0.341803603517843 7.65284640301576e-11 NA NA NA hsa-miR-106b-5p SNX16 2.80565545918114 1.14547999022566e-09 -0.459882875430995 0.326232769372022 MirTarget;miRNATAP -0.197126647533815 0.000445387445583766 NA NA NA hsa-miR-15b-5p SNX21 3.32329949959268 8.40210501034588e-13 -2.17996697832349 1.70827415073847e-07 mirMAP -0.169112719566097 0.000728876307097698 NA NA NA hsa-miR-21-5p SOCS5 2.65163477806992 6.72089787690756e-16 -1.13398715696047 0.000287928413880305 miRNAWalker2_validate -0.193685843333829 0.000218350167881486 NA NA NA hsa-miR-21-5p SOD3 2.65163477806992 6.72089787690756e-16 -4.34086617002263 1.34327820353508e-07 miRNAWalker2_validate;miRTarBase -0.466070662875393 0.000923787329131103 NA NA NA hsa-miR-106b-5p SORBS2 2.80565545918114 1.14547999022566e-09 -2.6641327162882 0.0576278285134523 MirTarget -0.37287380742321 0.0283067006275443 NA NA NA hsa-miR-21-3p SORCS1 3.50297439576639 6.39946844099206e-10 -4.74873786164687 0.000348414160792994 MirTarget -0.733477679115292 1.02929274731697e-08 NA NA NA hsa-miR-21-5p SOX5 2.65163477806992 6.72089787690756e-16 -3.64313222083632 0.00325808126091727 miRNAWalker2_validate;miRTarBase;miRNATAP -1.13619484780852 3.07838648949423e-08 NA NA NA hsa-miR-21-5p SOX6 2.65163477806992 6.72089787690756e-16 0.0539154805282649 0.966530730321982 MirTarget;miRNATAP -0.434070731940246 0.0445414974824877 NA NA NA hsa-miR-21-3p SP4 3.50297439576639 6.39946844099206e-10 -0.613074478786744 0.204711209190005 MirTarget -0.246894017803002 9.43062588108695e-08 NA NA NA hsa-miR-21-5p SPATA18 2.65163477806992 6.72089787690756e-16 -0.00643579797851546 0.993510702130891 mirMAP -0.280939327770294 0.0345533009313849 NA NA NA hsa-miR-21-5p SPEF2 2.65163477806992 6.72089787690756e-16 -3.6676120132626 0.0037840868745513 MirTarget -0.49376767332467 0.0211631793447036 NA NA NA hsa-miR-21-5p SPIN1 2.65163477806992 6.72089787690756e-16 -0.752720704381733 0.0300774324488204 miRNAWalker2_validate;miRNATAP -0.123252095225349 0.0343391292555945 NA NA NA hsa-miR-99a-5p SPIRE1 -2.72139054000803 0.00621971944534118 -0.909897428574929 0.201851106358037 miRNAWalker2_validate -0.122475727580902 0.00235427482978103 NA NA NA hsa-miR-21-5p SPOCK1 2.65163477806992 6.72089787690756e-16 -3.14469859711893 0.0072981104184964 MirTarget -0.596817766125623 0.00250096401613531 NA NA NA hsa-miR-106b-5p SPRED1 2.80565545918114 1.14547999022566e-09 -1.20771019802783 0.00430481333608872 miRNATAP -0.118278333355742 0.0209945636855123 NA NA NA hsa-miR-125a-5p SPRR3 -1.32352790615388 0.00714301627309467 5.69889277416237 0.0503817303119048 miRanda -2.33531539669061 7.61140587576985e-13 NA NA NA hsa-miR-335-5p SPRR3 0.167216045757305 0.803897055331049 5.69889277416237 0.0503817303119048 miRNAWalker2_validate -1.65624570750217 3.83554686500038e-12 NA NA NA hsa-miR-338-3p SPRR3 0.447551118940466 0.558485097370031 5.69889277416237 0.0503817303119048 miRanda -1.20561854504556 1.35975749339322e-08 NA NA NA hsa-miR-21-5p SPRY1 2.65163477806992 6.72089787690756e-16 -3.2710013892746 9.11497674299647e-06 miRNATAP -0.54085988562774 1.3604058677687e-05 24155920 Functional studies showed that miR-21 over-expression in GICs induced comparable cell differentiation features and targeted SPRY1 mRNA which encodes for a negative regulator of neural stem-cell differentiation differentiation glioblastoma hsa-miR-21-5p SPRY2 2.65163477806992 6.72089787690756e-16 -1.84053927439631 0.0157145497129286 miRNAWalker2_validate;miRTarBase;miRNATAP -0.46955875121018 0.000234633397177895 22322462 Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon tumorigenesis colon cancer hsa-miR-15b-3p SPRY3 3.57530146629867 5.89922785773482e-11 -0.618370143930133 0.359933803484397 mirMAP -0.178828419864989 0.00865010491618416 NA NA NA hsa-miR-21-3p SPRY3 3.50297439576639 6.39946844099206e-10 -0.618370143930133 0.359933803484397 mirMAP -0.351514935845698 5.36411571136968e-08 NA NA NA hsa-miR-15b-5p SPRY4 3.32329949959268 8.40210501034588e-13 -1.47925433496862 0.0430344985688012 miRNATAP -0.172871276981684 0.0466430399076407 NA NA NA hsa-miR-15b-5p SPRYD3 3.32329949959268 8.40210501034588e-13 -1.6702200600354 1.87780089875261e-08 MirTarget;miRNATAP -0.242981936018156 2.12441762514604e-12 NA NA NA hsa-miR-15b-5p SRC 3.32329949959268 8.40210501034588e-13 0.102375024620883 0.79702294660252 mirMAP -0.127054959100803 0.00672196853750947 NA NA NA hsa-miR-21-3p SRCIN1 3.50297439576639 6.39946844099206e-10 1.00597430749328 0.285142652933759 MirTarget -0.24192985261871 0.00841069247592699 NA NA NA hsa-miR-106b-5p SRL 2.80565545918114 1.14547999022566e-09 -4.71138173093858 1.38398870153932e-06 mirMAP -0.456776155414823 0.000126156587472607 NA NA NA hsa-miR-106b-5p SSBP2 2.80565545918114 1.14547999022566e-09 -1.51535320313589 0.0249815831142916 mirMAP -0.292465974187728 0.000325235687400327 NA NA NA hsa-miR-15b-3p SSBP2 3.57530146629867 5.89922785773482e-11 -1.51535320313589 0.0249815831142916 miRNATAP -0.153923828070318 0.0246336391793183 NA NA NA hsa-miR-15b-5p SSH1 3.32329949959268 8.40210501034588e-13 -0.419190007686638 0.258299199520312 mirMAP -0.118254408537716 0.00679467174156008 NA NA NA hsa-miR-21-3p SSPN 3.50297439576639 6.39946844099206e-10 -3.53387575911126 7.65231439695826e-06 MirTarget -0.289101972852773 0.000200911696037558 NA NA NA hsa-miR-106b-5p ST3GAL1 2.80565545918114 1.14547999022566e-09 -0.57392392965691 0.399077937645315 miRNATAP -0.225471582882208 0.00596236149842941 NA NA NA hsa-miR-15b-3p ST6GAL2 3.57530146629867 5.89922785773482e-11 -2.257605369786 0.0781882276295061 mirMAP -0.555344134044338 1.52327298722562e-05 NA NA NA hsa-miR-106b-5p ST6GALNAC3 2.80565545918114 1.14547999022566e-09 -4.70303406781754 1.3779426961271e-09 MirTarget -0.305113908710338 0.00150028742425234 NA NA NA hsa-miR-15b-3p ST6GALNAC3 3.57530146629867 5.89922785773482e-11 -4.70303406781754 1.3779426961271e-09 MirTarget -0.426281792535902 7.28430233855581e-08 NA NA NA hsa-miR-106b-5p ST6GALNAC6 2.80565545918114 1.14547999022566e-09 -1.93440076673466 3.64571751264529e-08 MirTarget;miRNATAP -0.14975786915282 0.000497666900553172 NA NA NA hsa-miR-106b-5p STAT3 2.80565545918114 1.14547999022566e-09 0.0160861395507963 0.957262386811393 miRNATAP -0.109483404039862 0.00226965981619241 27325313 We also found that EMMPRIN could down-regulate miR-106a and miR-106b expression in breast cancer cells which led to activating STAT3 and enhancing HIF-1α expression breast cancer hsa-miR-21-3p STAT5B 3.50297439576639 6.39946844099206e-10 -2.15100735109765 1.31811971048943e-10 MirTarget -0.123689092056195 0.000210151932233511 NA NA NA hsa-miR-99a-5p STEAP4 -2.72139054000803 0.00621971944534118 -0.895741342414595 0.533510825353429 miRNAWalker2_validate -0.166053747396002 0.0418448046896754 NA NA NA hsa-miR-15b-5p STIM1 3.32329949959268 8.40210501034588e-13 -0.592074966652905 0.103135374045345 MirTarget -0.189952755498468 7.45644139864273e-06 NA NA NA hsa-miR-21-5p STK40 2.65163477806992 6.72089787690756e-16 -0.808967915673855 0.00954765874262384 MirTarget;miRNATAP -0.181525025807584 0.000490969602635549 NA NA NA hsa-miR-106b-5p STOM 2.80565545918114 1.14547999022566e-09 -0.781277922526849 0.145871553962122 MirTarget -0.274465698511443 1.89734516469008e-05 NA NA NA hsa-miR-106b-5p STX12 2.80565545918114 1.14547999022566e-09 -0.912163617902765 0.00093261878366677 miRNAWalker2_validate -0.170590971087345 1.82125655997785e-07 NA NA NA hsa-miR-106b-5p STX1B 2.80565545918114 1.14547999022566e-09 -2.34344378683189 0.0065048363022665 mirMAP -0.296977376740438 0.00441907762381101 NA NA NA hsa-miR-21-3p STX1B 3.50297439576639 6.39946844099206e-10 -2.34344378683189 0.0065048363022665 mirMAP -0.178778760343888 0.0345615550561243 NA NA NA hsa-miR-15b-3p STXBP5L 3.57530146629867 5.89922785773482e-11 -4.82440839935231 0.000407136166985305 mirMAP;miRNATAP -0.461945277223592 0.000858351661463302 NA NA NA hsa-miR-15b-5p SUFU 3.32329949959268 8.40210501034588e-13 -0.5527380661751 0.0760053691606687 mirMAP -0.103010226586304 0.00495953553034903 NA NA NA hsa-miR-106b-5p SV2B 2.80565545918114 1.14547999022566e-09 -2.05886345743427 0.106689040731223 MirTarget;mirMAP -0.463621060348777 0.00260182747415463 NA NA NA hsa-miR-21-3p SV2B 3.50297439576639 6.39946844099206e-10 -2.05886345743427 0.106689040731223 mirMAP -0.559366731804446 5.72977081510417e-06 NA NA NA hsa-miR-217 SYCP2 -0.378397407994341 0.717408682071252 4.92682575432827 0.000879508610516831 MirTarget;miRanda -0.300654701175972 0.000204520907150708 NA NA NA hsa-miR-421 SYCP2 1.97624148591545 0.000915838012451138 4.92682575432827 0.000879508610516831 miRanda -0.354598457980488 0.012528973014644 NA NA NA hsa-miR-15b-5p SYDE1 3.32329949959268 8.40210501034588e-13 -2.73422804199318 0.000797548057676696 miRNATAP -0.500232774006971 1.70160209066239e-07 NA NA NA hsa-miR-106b-5p SYNE1 2.80565545918114 1.14547999022566e-09 -3.83488735412043 2.88145611550563e-08 MirTarget -0.480980375459367 8.64860011989173e-09 NA NA NA hsa-miR-15b-5p SYNE1 3.32329949959268 8.40210501034588e-13 -3.83488735412043 2.88145611550563e-08 MirTarget -0.455868752484371 2.83044718162137e-08 NA NA NA hsa-miR-106b-5p SYNPO 2.80565545918114 1.14547999022566e-09 -1.43431011609041 0.0258950704849837 mirMAP -0.297339486059045 0.000121398074623481 NA NA NA hsa-miR-15b-5p SYNPO 3.32329949959268 8.40210501034588e-13 -1.43431011609041 0.0258950704849837 mirMAP -0.237442438182633 0.00183005930471307 NA NA NA hsa-miR-106b-5p TACC1 2.80565545918114 1.14547999022566e-09 -2.887195149877 5.78630125029611e-09 MirTarget -0.346552268727451 7.72588603354511e-09 NA NA NA hsa-miR-15b-3p TACC1 3.57530146629867 5.89922785773482e-11 -2.887195149877 5.78630125029611e-09 mirMAP -0.268710290500673 9.73759837008592e-08 NA NA NA hsa-miR-15b-5p TACC1 3.32329949959268 8.40210501034588e-13 -2.887195149877 5.78630125029611e-09 MirTarget -0.244182345084757 4.24981678987494e-05 NA NA NA hsa-miR-21-5p TAF5 2.65163477806992 6.72089787690756e-16 0.438091697032009 0.1447684352778 miRNAWalker2_validate;miRNATAP -0.163781656194661 0.00104573380348084 NA NA NA hsa-miR-15b-5p TAL1 3.32329949959268 8.40210501034588e-13 -3.89540697095207 6.45138215770759e-09 mirMAP -0.42807329606406 8.91931108139162e-08 NA NA NA hsa-miR-106b-5p TAOK3 2.80565545918114 1.14547999022566e-09 0.114043662398584 0.775639161459909 MirTarget -0.172769690590989 0.000303902543696555 NA NA NA hsa-miR-21-3p TBC1D24 3.50297439576639 6.39946844099206e-10 1.55158382048432 0.000155139853004878 MirTarget -0.105121204691545 0.00911695668080066 NA NA NA hsa-miR-21-3p TBC1D4 3.50297439576639 6.39946844099206e-10 -0.429871520793351 0.457107343997304 MirTarget -0.114371953064197 0.0426483912190882 NA NA NA hsa-miR-106b-5p TBC1D8B 2.80565545918114 1.14547999022566e-09 -0.193367964368804 0.778568226560982 MirTarget -0.280499426460965 0.000678102208907385 NA NA NA hsa-miR-106b-5p TBC1D9 2.80565545918114 1.14547999022566e-09 -0.14702743407163 0.789708133510869 miRNAWalker2_validate;miRNATAP -0.188171842682042 0.00454025806559184 NA NA NA hsa-miR-106b-5p TBCEL 2.80565545918114 1.14547999022566e-09 -0.905991999959654 0.0526960941673488 MirTarget -0.175031034057022 0.00187323819446946 NA NA NA hsa-miR-106b-5p TBX3 2.80565545918114 1.14547999022566e-09 -2.28656195964015 0.00770123000954135 miRNATAP -0.353992257555507 0.000634796373873901 NA NA NA hsa-miR-106b-5p TCEAL1 2.80565545918114 1.14547999022566e-09 -3.51341768981975 8.06608935828474e-15 miRNAWalker2_validate;miRTarBase -0.245469771993841 1.41600028487666e-05 NA NA NA hsa-miR-15b-3p TCF12 3.57530146629867 5.89922785773482e-11 -0.64144102181344 0.129741633906277 mirMAP -0.106399001206432 0.0126353864319277 NA NA NA hsa-miR-106b-5p TCF21 2.80565545918114 1.14547999022566e-09 -7.33832795552009 1.01491937742661e-07 mirMAP -1.07051125446932 9.51450077019856e-11 NA NA NA hsa-miR-21-5p TCF21 2.65163477806992 6.72089787690756e-16 -7.33832795552009 1.01491937742661e-07 miRNAWalker2_validate -0.716115225486907 0.00242485631156879 NA NA NA hsa-miR-106b-5p TCF4 2.80565545918114 1.14547999022566e-09 -2.23433165372064 0.00194262002575201 miRNATAP -0.335619614859467 0.000114215246338324 NA NA NA hsa-miR-15b-3p TCF4 3.57530146629867 5.89922785773482e-11 -2.23433165372064 0.00194262002575201 mirMAP -0.236109725399629 0.00122376087993195 NA NA NA hsa-miR-21-3p TEF 3.50297439576639 6.39946844099206e-10 -1.65345931588579 0.00309485334315252 MirTarget -0.186170417777418 0.000646564594925482 NA NA NA hsa-miR-21-5p TET1 2.65163477806992 6.72089787690756e-16 -1.1952500612559 0.220389914669266 miRNAWalker2_validate -0.686999087136622 2.31163426135523e-05 NA NA NA hsa-miR-106b-5p TGFBR2 2.80565545918114 1.14547999022566e-09 -2.73335386207413 1.90521047769449e-05 miRNATAP -0.322471465860215 3.16067025691578e-05 NA NA NA hsa-miR-15a-5p TGFBR3 2.0535411006904 1.91108976398046e-06 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.398252051497784 0.000579622324303971 NA NA NA hsa-miR-15b-5p TGFBR3 3.32329949959268 8.40210501034588e-13 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.308598579670601 0.00329766225446434 NA NA NA hsa-miR-16-2-3p TGFBR3 3.79845098071094 1.49120139344659e-13 -4.8172798831592 2.83698243439907e-08 mirMAP -0.510816849440913 3.63317831108554e-08 NA NA NA hsa-miR-16-5p TGFBR3 2.93575808220754 2.15436817162977e-10 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.398826844441648 0.000167618497525506 NA NA NA hsa-miR-18a-3p TGFBR3 3.64944956993027 7.20156641833731e-07 -4.8172798831592 2.83698243439907e-08 MirTarget -0.276229137548183 3.81281614466793e-05 NA NA NA hsa-miR-18a-5p TGFBR3 3.90770175770219 9.15298615034137e-10 -4.8172798831592 2.83698243439907e-08 MirTarget -0.313514148171929 3.94123087172394e-05 NA NA NA hsa-miR-193a-3p TGFBR3 0.646392169474854 0.207134343676122 -4.8172798831592 2.83698243439907e-08 MirTarget;miRanda;miRNATAP -0.215716666155859 0.0296006045254786 NA NA NA hsa-miR-193b-3p TGFBR3 1.35015762547152 0.0874921379319504 -4.8172798831592 2.83698243439907e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.155998259134538 0.0143564220097533 NA NA NA hsa-miR-21-5p TGFBR3 2.65163477806992 6.72089787690756e-16 -4.8172798831592 2.83698243439907e-08 miRNAWalker2_validate -0.67212333147917 5.19481182016835e-06 NA NA NA hsa-miR-222-5p TGFBR3 2.52056758362407 0.00142010793166944 -4.8172798831592 2.83698243439907e-08 MirTarget -0.352823463780761 1.35483244347225e-08 NA NA NA hsa-miR-27a-3p TGFBR3 1.76094007417453 0.000216137556256765 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.352585790116035 0.000816843585172177 NA NA NA hsa-miR-27b-3p TGFBR3 -0.0929089601968123 0.85847352206581 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.287369611968484 0.00313932913796485 NA NA NA hsa-miR-33a-3p TGFBR3 2.06269680799532 0.00156436055383943 -4.8172798831592 2.83698243439907e-08 mirMAP -0.24065182722194 0.00179364317738789 NA NA NA hsa-miR-484 TGFBR3 1.79050445056016 0.000217287101253701 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.315397888660127 0.00235031958258578 NA NA NA hsa-miR-590-3p TGFBR3 2.35429565068338 2.79601879608564e-06 -4.8172798831592 2.83698243439907e-08 MirTarget;miRanda;mirMAP -0.285337459789671 0.00402891046812002 NA NA NA hsa-miR-590-5p TGFBR3 1.51400888103768 0.0023888567923017 -4.8172798831592 2.83698243439907e-08 miRanda -0.252632750733014 0.0125811995597262 NA NA NA hsa-miR-627-5p TGFBR3 1.68461263902065 0.00697075274507733 -4.8172798831592 2.83698243439907e-08 MirTarget -0.254442023518234 0.0016844231918282 NA NA NA hsa-miR-944 TGFBR3 7.20925181386398 0.000823207457340648 -4.8172798831592 2.83698243439907e-08 mirMAP -0.130912091086309 4.23191284323791e-06 NA NA NA hsa-miR-106b-5p TGM2 2.80565545918114 1.14547999022566e-09 -3.1811826378625 0.00352731383378931 MirTarget -0.6435182857967 8.22271104435605e-07 NA NA NA hsa-miR-106b-5p THBS2 2.80565545918114 1.14547999022566e-09 -2.62795619060355 0.00635907547670508 MirTarget -0.754072944240837 2.88430240077148e-11 NA NA NA hsa-miR-15b-5p THRA 3.32329949959268 8.40210501034588e-13 -2.81473866933756 1.85535002449113e-09 miRNAWalker2_validate -0.126370824517499 0.0265401765697274 NA NA NA hsa-miR-106b-5p THSD4 2.80565545918114 1.14547999022566e-09 -2.54781480628833 0.0103516297336666 mirMAP -0.364282964269995 0.00244599498014174 NA NA NA hsa-miR-15b-5p THSD4 3.32329949959268 8.40210501034588e-13 -2.54781480628833 0.0103516297336666 MirTarget -0.301138790875806 0.0108241536581837 NA NA NA hsa-miR-106b-5p TIAM1 2.80565545918114 1.14547999022566e-09 -0.301678277646937 0.688259432821498 MirTarget;miRNATAP -0.376927369307084 2.71968335511411e-05 NA NA NA hsa-miR-106b-5p TIMP2 2.80565545918114 1.14547999022566e-09 -3.59794494522838 2.10429352476442e-07 miRNATAP -0.495099073808881 2.94951754008007e-09 NA NA NA hsa-miR-15b-3p TIMP2 3.57530146629867 5.89922785773482e-11 -3.59794494522838 2.10429352476442e-07 MirTarget -0.344501668970755 9.9794978433679e-07 NA NA NA hsa-miR-106b-5p TIMP3 2.80565545918114 1.14547999022566e-09 -4.5244412907566 3.61006423790288e-06 miRNATAP -0.683923114467903 5.3734627495312e-09 NA NA NA hsa-miR-15b-5p TLL1 3.32329949959268 8.40210501034588e-13 -3.32547247487436 0.0110908170301251 miRNATAP -0.407181780420537 0.00891219054979299 NA NA NA hsa-miR-106b-5p TMCC3 2.80565545918114 1.14547999022566e-09 -0.269963715814735 0.740318362950827 miRNATAP -0.299680845493275 0.00222488332005463 NA NA NA hsa-miR-21-3p TMEFF1 3.50297439576639 6.39946844099206e-10 -0.576201765093648 0.402191436031652 MirTarget -0.193628151775475 0.00382557137464228 NA NA NA hsa-miR-15b-5p TMEM100 3.32329949959268 8.40210501034588e-13 -4.85132923899393 0.000514110649937023 MirTarget -0.397138428771751 0.0174055983285761 NA NA NA hsa-miR-15b-5p TMEM108 3.32329949959268 8.40210501034588e-13 -4.43528701331025 0.000246845664311724 mirMAP -0.556327215866925 0.000108507564421913 NA NA NA hsa-miR-106b-5p TMEM130 2.80565545918114 1.14547999022566e-09 -3.4516648419652 0.00494436357179222 mirMAP -0.839923059891723 8.62424155871178e-09 NA NA NA hsa-miR-15b-5p TMEM130 3.32329949959268 8.40210501034588e-13 -3.4516648419652 0.00494436357179222 mirMAP -0.716094549302288 6.70364729337654e-07 NA NA NA hsa-miR-15b-5p TMEM135 3.32329949959268 8.40210501034588e-13 -0.181395428831006 0.661915991955555 MirTarget -0.100124640525299 0.0410397799268117 NA NA NA hsa-miR-21-5p TMEM170B 2.65163477806992 6.72089787690756e-16 -2.18294059191507 0.00216562049032245 mirMAP -0.503277943311044 2.40608807326274e-05 NA NA NA hsa-miR-15b-5p TMEM198 3.32329949959268 8.40210501034588e-13 -1.30275918023503 0.0582454156454248 MirTarget -0.193564957212877 0.017685036690134 NA NA NA hsa-miR-15b-5p TMEM43 3.32329949959268 8.40210501034588e-13 -1.33845768171733 0.000183832694314726 miRNAWalker2_validate;MirTarget -0.170026646159003 5.78283621394678e-05 NA NA NA hsa-miR-15b-3p TMEM47 3.57530146629867 5.89922785773482e-11 -4.55580373424323 8.95296387773798e-06 MirTarget;miRNATAP -0.313817376388518 0.00278722014317615 NA NA NA hsa-miR-21-3p TMEM47 3.50297439576639 6.39946844099206e-10 -4.55580373424323 8.95296387773798e-06 MirTarget -0.324042916077492 0.00138300582385579 NA NA NA hsa-miR-15b-5p TMEM55A 3.32329949959268 8.40210501034588e-13 -3.05359818310335 3.43096750146305e-05 MirTarget -0.216056293718228 0.0145117469673228 NA NA NA hsa-miR-106b-5p TMOD2 2.80565545918114 1.14547999022566e-09 -1.55872706933157 0.0221432294070425 mirMAP -0.341706165797283 2.89727422802382e-05 NA NA NA hsa-miR-106b-5p TMOD3 2.80565545918114 1.14547999022566e-09 0.935595180098963 0.0322846945401796 mirMAP -0.140999169742613 0.00748531280276784 NA NA NA hsa-miR-106b-5p TNFAIP8L3 2.80565545918114 1.14547999022566e-09 -5.12415185649202 4.47519817305142e-07 mirMAP -0.537364370405432 1.40582655802257e-05 NA NA NA hsa-miR-15b-5p TNFAIP8L3 3.32329949959268 8.40210501034588e-13 -5.12415185649202 4.47519817305142e-07 MirTarget -0.404611985765572 0.000922952357796564 NA NA NA hsa-miR-15b-3p TNKS 3.57530146629867 5.89922785773482e-11 -0.460429001414743 0.212125578165966 mirMAP -0.103579397179255 0.00520489061709678 NA NA NA hsa-miR-21-3p TNRC6B 3.50297439576639 6.39946844099206e-10 -0.253746674677191 0.452320328040706 mirMAP -0.134406274406481 3.49377124236821e-05 NA NA NA hsa-miR-106b-3p TNRC6C 2.57689304590494 1.04870442173494e-07 -1.7285591979257 0.000175248956743303 miRNATAP -0.149308014504897 0.00531290348296489 NA NA NA hsa-miR-21-3p TNRC6C 3.50297439576639 6.39946844099206e-10 -1.7285591979257 0.000175248956743303 mirMAP -0.289321126335221 4.82618516164697e-11 NA NA NA hsa-miR-15b-5p TNS3 3.32329949959268 8.40210501034588e-13 -1.50902990570292 0.0188002383403864 mirMAP -0.214908338735369 0.0047686840593257 NA NA NA hsa-miR-106b-5p TOLLIP 2.80565545918114 1.14547999022566e-09 -0.0565714251904401 0.887847982134862 MirTarget -0.119729014775001 0.0130264211185298 NA NA NA hsa-miR-15b-5p TOM1L2 3.32329949959268 8.40210501034588e-13 -0.464280047034929 0.406868170320627 mirMAP -0.149337057620643 0.0241323925367817 NA NA NA hsa-miR-106b-5p TP53INP2 2.80565545918114 1.14547999022566e-09 -1.3567977154572 0.0407498178846371 MirTarget;miRNATAP -0.245753301624335 0.00212332680307506 NA NA NA hsa-miR-21-5p TPM1 2.65163477806992 6.72089787690756e-16 -3.85847267907588 1.11233400104492e-06 miRNAWalker2_validate;miRTarBase -0.273357839556409 0.0439482804838394 20952761;23558936 These two miRNAs have previously been identified as being overexpressed in MCF-7 breast cancer cells with miR-21 specifically implicated in down-regulating the tumor suppressor gene tropomyosin-1;Furthermore miR-21 mimic or inhibitor significantly reduced or increased the expression of PDCD4 and TPM1; MiR-21 is overexpressed in RCC tissue and modulates the growth apoptosis and cell cycle progression of RCC cells and regulates the expression of PDCD4 and TPM1 ;progression breast cancer;kidney renal cell cancer hsa-miR-15b-5p TPM2 3.32329949959268 8.40210501034588e-13 -4.41920599687158 4.0638739076821e-08 MirTarget -0.232687807057556 0.0171374579046231 NA NA NA hsa-miR-21-5p TPRG1L 2.65163477806992 6.72089787690756e-16 -1.04574916436371 0.00967604124151036 miRNAWalker2_validate;MirTarget -0.14590846569762 0.0320185768036449 NA NA NA hsa-miR-15b-5p TRANK1 3.32329949959268 8.40210501034588e-13 -0.693678262784126 0.227977477992206 MirTarget;miRNATAP -0.21242148020261 0.00174703592873349 NA NA NA hsa-miR-21-5p TRAPPC2 2.65163477806992 6.72089787690756e-16 -0.295785498751062 0.363852400664171 miRNAWalker2_validate -0.117913890433964 0.030338573005651 NA NA NA hsa-miR-106b-5p TRERF1 2.80565545918114 1.14547999022566e-09 0.0839502090137945 0.900476732581205 mirMAP -0.269007513785903 0.000843791604916891 NA NA NA hsa-miR-21-5p TRIM2 2.65163477806992 6.72089787690756e-16 -0.881955199412192 0.377712461906717 miRNAWalker2_validate;mirMAP;miRNATAP -0.610064165432885 0.000257251797962065 NA NA NA hsa-miR-21-5p TRIM33 2.65163477806992 6.72089787690756e-16 0.135342722521718 0.642257723898512 miRNAWalker2_validate;miRNATAP -0.10698727261632 0.0276704021459775 NA NA NA hsa-miR-21-3p TRIM66 3.50297439576639 6.39946844099206e-10 -0.00555275864204363 0.990678199154217 mirMAP -0.18458751768108 5.71194873056745e-05 NA NA NA hsa-miR-106b-5p TRIOBP 2.80565545918114 1.14547999022566e-09 -0.770711166379448 0.022546456237445 mirMAP -0.161676909629777 6.25965356866681e-05 NA NA NA hsa-miR-106b-5p TRIP10 2.80565545918114 1.14547999022566e-09 -0.259911837310717 0.528795845648471 miRNATAP -0.195520267205346 7.17894131298176e-05 NA NA NA hsa-miR-15b-5p TRIP10 3.32329949959268 8.40210501034588e-13 -0.259911837310717 0.528795845648471 miRNATAP -0.153436683883745 0.00156656654686786 NA NA NA hsa-miR-15b-5p TSC22D3 3.32329949959268 8.40210501034588e-13 -2.19623478335286 0.00105481803029302 miRNATAP -0.162986602277225 0.0418437200505702 NA NA NA hsa-miR-21-5p TSHZ1 2.65163477806992 6.72089787690756e-16 -1.1244499691137 0.0323315271785929 miRNATAP -0.2692787074674 0.00224137014995987 NA NA NA hsa-miR-106b-5p TSHZ3 2.80565545918114 1.14547999022566e-09 -3.16568181185487 0.000170463582155262 MirTarget;miRNATAP -0.41655156442112 4.319872108299e-05 NA NA NA hsa-miR-21-5p TSNAX 2.65163477806992 6.72089787690756e-16 -0.247489601220529 0.351350829439706 miRNAWalker2_validate -0.153162575029091 0.000495978986325268 NA NA NA hsa-miR-106b-5p TSPAN5 2.80565545918114 1.14547999022566e-09 -0.975385967333399 0.344219429992479 mirMAP -0.368332979312114 0.00302854742129933 NA NA NA hsa-miR-15b-5p TSPAN5 3.32329949959268 8.40210501034588e-13 -0.975385967333399 0.344219429992479 MirTarget;miRNATAP -0.344031200970034 0.00477759695394481 NA NA NA hsa-miR-106b-5p TSPAN9 2.80565545918114 1.14547999022566e-09 -1.27701951417754 0.00771150702435207 MirTarget;miRNATAP -0.131845968294429 0.0231732836097915 NA NA NA hsa-miR-106b-5p TSPYL5 2.80565545918114 1.14547999022566e-09 -4.28827645202997 9.9713229622099e-05 mirMAP -0.618459307827884 3.27446067301705e-06 NA NA NA hsa-miR-21-5p TTC33 2.65163477806992 6.72089787690756e-16 -1.17841172976318 0.00122542336971668 miRNAWalker2_validate -0.158817153146563 0.00968073740513819 NA NA NA hsa-miR-106b-5p TTC9 2.80565545918114 1.14547999022566e-09 2.66493998507301 0.0035557233495781 miRNATAP -0.252165284532631 0.0232546253875691 NA NA NA hsa-miR-140-5p TTK -0.634610285725923 0.126670572966239 6.17200809754619 1.02416279686047e-42 miRanda;miRNATAP -0.196596686586982 0.00610350815034159 NA NA NA hsa-miR-106b-5p TTLL7 2.80565545918114 1.14547999022566e-09 -1.21179952611193 0.380245236976177 mirMAP -0.476634774265182 0.00419907996069515 NA NA NA hsa-miR-15b-5p TUBA1A 3.32329949959268 8.40210501034588e-13 -2.89269929629878 3.14200909792898e-08 MirTarget;miRNATAP -0.146404065217204 0.0207851363913716 NA NA NA hsa-miR-106b-5p TXNIP 2.80565545918114 1.14547999022566e-09 -2.57627281923689 0.000174676475402869 MirTarget -0.345968905636241 3.02661827893705e-05 NA NA NA hsa-miR-106b-5p UACA 2.80565545918114 1.14547999022566e-09 -0.592116558720316 0.138247010996636 mirMAP -0.11687353558596 0.0151264129550935 NA NA NA hsa-miR-15b-5p UACA 3.32329949959268 8.40210501034588e-13 -0.592116558720316 0.138247010996636 miRNAWalker2_validate -0.123556533611446 0.0087746617769343 NA NA NA hsa-miR-15b-3p UBE2QL1 3.57530146629867 5.89922785773482e-11 -2.02004116645282 0.0467740689884088 mirMAP -0.280359619626323 0.00635781311334075 NA NA NA hsa-miR-15b-5p UBE4A 3.32329949959268 8.40210501034588e-13 -0.294309663519086 0.327007234422356 MirTarget -0.141145960364182 5.56302274669041e-05 NA NA NA hsa-miR-21-3p UBE4B 3.50297439576639 6.39946844099206e-10 -0.073459454633638 0.838597920181733 MirTarget -0.109206395814879 0.00175776900465791 NA NA NA hsa-miR-15b-5p UBL3 3.32329949959268 8.40210501034588e-13 -1.80359427205349 1.37857879455126e-05 MirTarget -0.138748578970518 0.00516524379997966 NA NA NA hsa-miR-21-5p UBR3 2.65163477806992 6.72089787690756e-16 -0.371039991204636 0.227747850916614 miRNAWalker2_validate;MirTarget;miRNATAP -0.153436954235561 0.00274149790166264 NA NA NA hsa-miR-106b-5p USP31 2.80565545918114 1.14547999022566e-09 -0.678837940286817 0.134901889034998 MirTarget;miRNATAP -0.125544201698936 0.0218963118410243 NA NA NA hsa-miR-21-3p USP44 3.50297439576639 6.39946844099206e-10 -2.56853309558035 0.0737487135634757 MirTarget -0.391413734562425 0.00527902805282985 NA NA NA hsa-miR-21-3p USP46 3.50297439576639 6.39946844099206e-10 0.119607155283224 0.759937239225902 MirTarget -0.137450137616583 0.000278205789013994 NA NA NA hsa-miR-21-5p USP47 2.65163477806992 6.72089787690756e-16 -0.781858010153612 0.00289656565024053 miRNAWalker2_validate -0.170832300888402 9.03585792967657e-05 NA NA NA hsa-miR-21-3p USP51 3.50297439576639 6.39946844099206e-10 -1.15308180466928 0.229639113438818 MirTarget -0.676518168928393 5.64752024058115e-14 NA NA NA hsa-miR-106b-5p UTP14C 2.80565545918114 1.14547999022566e-09 -0.527468605561612 0.159426011592721 MirTarget -0.119934097842016 0.00779463221966963 NA NA NA hsa-miR-21-5p VASH2 2.65163477806992 6.72089787690756e-16 -0.298537865169998 0.75615306742915 miRNAWalker2_validate -0.645379480545345 5.50486089869963e-05 NA NA NA hsa-miR-15b-5p VAT1 3.32329949959268 8.40210501034588e-13 -1.53645875557473 2.00668340308621e-05 MirTarget;miRNATAP -0.160041815541496 0.000184214191347888 NA NA NA hsa-miR-21-5p VEZF1 2.65163477806992 6.72089787690756e-16 -0.988942415107107 0.00580650823261927 mirMAP -0.12958379547762 0.0317228716071858 NA NA NA hsa-miR-106b-5p VGLL3 2.80565545918114 1.14547999022566e-09 -3.67857910192456 0.00250435275558057 mirMAP -0.532008778357146 0.000298562975327557 NA NA NA hsa-miR-106b-5p VLDLR 2.80565545918114 1.14547999022566e-09 -0.496825111317726 0.556906696166297 MirTarget;miRNATAP -0.240919872289619 0.0182684212584893 NA NA NA hsa-miR-15b-5p VPS13B 3.32329949959268 8.40210501034588e-13 -0.690050511824246 0.0691926675014511 mirMAP -0.127151456426471 0.00453420940374746 NA NA NA hsa-miR-106b-5p VPS13C 2.80565545918114 1.14547999022566e-09 -0.902635302113003 0.0732106668702377 MirTarget -0.119883427989843 0.0491227675822936 NA NA NA hsa-miR-21-5p VPS54 2.65163477806992 6.72089787690756e-16 -0.0571083596206243 0.84117485962005 miRNAWalker2_validate -0.101932725019505 0.0319207540593606 NA NA NA hsa-miR-15b-5p VWF 3.32329949959268 8.40210501034588e-13 -3.42077216872826 7.3563996629188e-08 mirMAP -0.481328940304442 1.19557042925501e-10 NA NA NA hsa-miR-21-3p WASF3 3.50297439576639 6.39946844099206e-10 -2.83975078195081 0.0107635104996704 mirMAP -0.343713185427188 0.00158994127925795 NA NA NA hsa-miR-106b-5p WDFY3 2.80565545918114 1.14547999022566e-09 -0.583630892684813 0.139349880452974 MirTarget;miRNATAP -0.102231707988765 0.0317244703071824 NA NA NA hsa-miR-21-5p WFS1 2.65163477806992 6.72089787690756e-16 -2.82041783767624 7.52646548580149e-09 miRNAWalker2_validate -0.309911301393807 0.000203903828629456 NA NA NA hsa-miR-15b-5p WISP1 3.32329949959268 8.40210501034588e-13 -1.74294289428193 0.0475614603552572 MirTarget -0.455301211177607 1.0410561187271e-05 NA NA NA hsa-miR-106b-3p WNK1 2.57689304590494 1.04870442173494e-07 0.225279658220879 0.62839966029964 miRNAWalker2_validate -0.120586279226851 0.0245710260275173 NA NA NA hsa-miR-106b-5p WNK1 2.80565545918114 1.14547999022566e-09 0.225279658220879 0.62839966029964 miRNATAP -0.162544473593707 0.00365240412416874 NA NA NA hsa-miR-15b-3p WNT5A 3.57530146629867 5.89922785773482e-11 -0.335254267155151 0.714960765245992 mirMAP -0.24311589972858 0.00863820879774156 NA NA NA hsa-miR-15b-5p WNT7A 3.32329949959268 8.40210501034588e-13 1.99490211423871 0.283859716193086 MirTarget -0.65869802593554 0.00275936276249016 27195958 WNT7A Regulation by miR 15b in Ovarian Cancer; In the present study we report that WNT7A is a direct target of miR-15b in ovarian cancer; We showed that a luciferase reporter containing the putative binding site of miR-15b in the WNT7A 3'-UTR was significantly repressed by miR-15b; Mutation of the putative binding site of miR-15b in the WNT7A 3'-UTR restored luciferase activity; Furthermore miR-15b was able to repress increased levels of TOPFLASH activity by WNT7A but not those induced by S33Y; Additionally miR-15b dose-dependently decreased WNT7A expression; When we evaluated the prognostic impact of WNT7A and miR-15b expression using TCGA datasets a significant inverse correlation in which high-expression of WNT7A and low-expression of miR-15b was associated with reduced survival rates of ovarian cancer patients; These results suggest that WNT7A is post-transcriptionally regulated by miR-15b which could be down-regulated by promoter hypermethylation potentially via DNMT1 in ovarian cancer poor survival ovarian cancer hsa-miR-15b-5p WTIP 3.32329949959268 8.40210501034588e-13 -2.28702770726066 0.00408409230581306 mirMAP -0.212948719645637 0.0248556679062974 NA NA NA hsa-miR-106b-5p XRN1 2.80565545918114 1.14547999022566e-09 0.812766704331495 0.0482566415012292 MirTarget;miRNATAP -0.11212920873159 0.023994658690817 NA NA NA hsa-miR-106b-5p XYLT1 2.80565545918114 1.14547999022566e-09 -1.12818083225192 0.230679101009796 mirMAP -0.378391332113604 0.00083069371589042 NA NA NA hsa-miR-106b-5p YPEL2 2.80565545918114 1.14547999022566e-09 -1.47592182224331 0.00332117792525623 miRNATAP -0.300265804034333 5.64270694277285e-07 NA NA NA hsa-miR-106b-5p YPEL4 2.80565545918114 1.14547999022566e-09 -3.76000513753502 9.10701077224552e-08 MirTarget;miRNATAP -0.422430592686606 7.85389812271296e-07 NA NA NA hsa-miR-106b-5p ZBTB4 2.80565545918114 1.14547999022566e-09 -1.6354372701126 7.3529948879252e-07 MirTarget;miRNATAP -0.13738608331624 0.000639338424468288 NA NA NA hsa-miR-106b-5p ZBTB44 2.80565545918114 1.14547999022566e-09 -0.291431148166603 0.416897347016163 miRNATAP -0.119527862737112 0.00552154607073092 NA NA NA hsa-miR-15b-5p ZBTB46 3.32329949959268 8.40210501034588e-13 -2.41250735520314 0.000211131803481525 MirTarget -0.162996685636919 0.0364928767008244 NA NA NA hsa-miR-106b-5p ZBTB47 2.80565545918114 1.14547999022566e-09 -2.37545009960728 1.18663865199439e-09 MirTarget -0.214327659201832 7.39694507131909e-06 NA NA NA hsa-miR-106b-5p ZBTB7A 2.80565545918114 1.14547999022566e-09 0.0144059173078572 0.964659355741043 MirTarget;miRNATAP -0.138884605681593 0.00034228824385304 NA NA NA hsa-miR-21-5p ZBTB8A 2.65163477806992 6.72089787690756e-16 -1.01561461414937 0.000220878107435328 miRNAWalker2_validate -0.184521121128711 5.80070269097887e-05 NA NA NA hsa-miR-15b-3p ZC3H12B 3.57530146629867 5.89922785773482e-11 -3.5557136877298 1.55525144024858e-08 mirMAP -0.299090428411341 3.20588753419448e-06 NA NA NA hsa-miR-15b-5p ZC3H12B 3.32329949959268 8.40210501034588e-13 -3.5557136877298 1.55525144024858e-08 miRNATAP -0.22032284001681 0.00379614330657064 NA NA NA hsa-miR-15b-5p ZC3H6 3.32329949959268 8.40210501034588e-13 -1.39996693247178 0.0013964734780245 miRNATAP -0.103841544536682 0.046714990090899 NA NA NA hsa-miR-15b-5p ZDHHC15 3.32329949959268 8.40210501034588e-13 -4.93284359218268 0.000429826485965628 MirTarget -0.636816419306293 0.000128880109097493 NA NA NA hsa-miR-21-5p ZDHHC17 2.65163477806992 6.72089787690756e-16 -1.31128911038434 8.98249605689345e-06 miRNATAP -0.146590126009409 0.00330675037545971 NA NA NA hsa-miR-15b-3p ZFC3H1 3.57530146629867 5.89922785773482e-11 0.59656630181242 0.120519774533462 MirTarget -0.123282316763232 0.00139096083178741 NA NA NA hsa-miR-21-3p ZFHX3 3.50297439576639 6.39946844099206e-10 -1.01872991597482 0.0576587409447774 MirTarget -0.155601167354413 0.00292186772059346 NA NA NA hsa-miR-15b-5p ZFHX4 3.32329949959268 8.40210501034588e-13 -3.24470875467541 0.0166841002561569 MirTarget;miRNATAP -0.636577928514356 6.87659881259647e-05 NA NA NA hsa-miR-15b-3p ZFP30 3.57530146629867 5.89922785773482e-11 -0.735350395964987 0.357692387760878 mirMAP -0.205033693354557 0.0110453591741704 NA NA NA hsa-miR-106b-5p ZFPM2 2.80565545918114 1.14547999022566e-09 -4.98416670049111 3.64077996689347e-05 miRNATAP -0.566448899075379 0.000111862837338405 NA NA NA hsa-miR-21-3p ZFX 3.50297439576639 6.39946844099206e-10 -0.24812373338618 0.512115640771897 mirMAP -0.108968780369388 0.00298184878008917 NA NA NA hsa-miR-106b-5p ZFYVE21 2.80565545918114 1.14547999022566e-09 -1.22760169852189 0.000135271171060945 miRNATAP -0.125531604568457 0.00124981335090504 NA NA NA hsa-miR-106b-5p ZFYVE26 2.80565545918114 1.14547999022566e-09 0.348405057425081 0.244043082816309 MirTarget;miRNATAP -0.10416928287312 0.00361550936339287 NA NA NA hsa-miR-106b-5p ZHX2 2.80565545918114 1.14547999022566e-09 -1.10028616857542 0.00263511734608508 MirTarget;miRNATAP -0.176013030108887 6.11305857139986e-05 NA NA NA hsa-miR-106b-5p ZHX3 2.80565545918114 1.14547999022566e-09 -1.38921487884578 0.000335309419918514 mirMAP -0.124346382720044 0.00816083299003739 NA NA NA hsa-miR-15b-3p ZHX3 3.57530146629867 5.89922785773482e-11 -1.38921487884578 0.000335309419918514 mirMAP -0.120676583919531 0.00210283586416413 NA NA NA hsa-miR-21-3p ZHX3 3.50297439576639 6.39946844099206e-10 -1.38921487884578 0.000335309419918514 mirMAP -0.122448658311191 0.00123226295062415 NA NA NA hsa-miR-15b-3p ZIK1 3.57530146629867 5.89922785773482e-11 -3.1474919145676 0.000131796457800744 mirMAP -0.410857835554706 6.9595024228681e-07 NA NA NA hsa-miR-106b-5p ZMAT3 2.80565545918114 1.14547999022566e-09 -0.0572615713923394 0.923643721266638 mirMAP -0.231862038028038 0.00122840610622987 NA NA NA hsa-miR-15b-5p ZMIZ1 3.32329949959268 8.40210501034588e-13 -1.06818778537931 0.0115800720894118 mirMAP -0.117316320187292 0.0194137434815021 NA NA NA hsa-miR-15b-3p ZNF10 3.57530146629867 5.89922785773482e-11 -0.60339349247019 0.192840039375185 mirMAP -0.130807703120178 0.00503673699255796 NA NA NA hsa-miR-21-5p ZNF208 2.65163477806992 6.72089787690756e-16 -4.81678757597312 2.84677827799915e-06 mirMAP -0.418931638502308 0.0171851422525005 NA NA NA hsa-miR-21-3p ZNF217 3.50297439576639 6.39946844099206e-10 0.893889605523533 0.0523440275681692 MirTarget -0.140778295419804 0.00168302210520221 NA NA NA hsa-miR-15b-3p ZNF225 3.57530146629867 5.89922785773482e-11 -0.187240860268796 0.699349330530548 mirMAP -0.132053024479479 0.00678029174194693 NA NA NA hsa-miR-21-5p ZNF24 2.65163477806992 6.72089787690756e-16 -0.205310120383931 0.376971111089432 mirMAP -0.108829957941523 0.00469283789675044 NA NA NA hsa-miR-15b-3p ZNF248 3.57530146629867 5.89922785773482e-11 -1.17649177796295 0.000205495913168282 mirMAP -0.143196955264276 6.59793133094174e-06 NA NA NA hsa-miR-21-3p ZNF248 3.50297439576639 6.39946844099206e-10 -1.17649177796295 0.000205495913168282 MirTarget -0.233326640922977 4.09318973620157e-15 NA NA NA hsa-miR-106b-5p ZNF25 2.80565545918114 1.14547999022566e-09 -2.43850769102706 1.39867733021263e-12 miRNATAP -0.205056661560501 1.34449037679844e-06 NA NA NA hsa-miR-15b-3p ZNF268 3.57530146629867 5.89922785773482e-11 -0.649002122561196 0.465180083532507 mirMAP -0.238773474054855 0.00771920600649501 NA NA NA hsa-miR-21-5p ZNF280D 2.65163477806992 6.72089787690756e-16 -1.10230107773107 0.000567626645738733 mirMAP -0.147284338022593 0.00619638095782037 NA NA NA hsa-miR-21-5p ZNF292 2.65163477806992 6.72089787690756e-16 -0.0517446292592965 0.892823972162823 miRNAWalker2_validate -0.128005426200445 0.0465415591784301 NA NA NA hsa-miR-106b-5p ZNF333 2.80565545918114 1.14547999022566e-09 -1.54787547301119 3.37376375487998e-05 mirMAP -0.108647715662822 0.0169205231752793 NA NA NA hsa-miR-15b-5p ZNF423 3.32329949959268 8.40210501034588e-13 -4.44330743732874 5.41130570683002e-06 miRNATAP -0.487813052859711 2.80175697898744e-05 NA NA NA hsa-miR-15b-5p ZNF449 3.32329949959268 8.40210501034588e-13 -0.617388049511533 0.0871076483199239 MirTarget;miRNATAP -0.134782822807806 0.001503928590435 NA NA NA hsa-miR-21-5p ZNF451 2.65163477806992 6.72089787690756e-16 -0.562134303883099 0.044814908633505 mirMAP -0.113547696463513 0.0152576836946386 NA NA NA hsa-miR-106b-5p ZNF470 2.80565545918114 1.14547999022566e-09 -2.6600857696884 0.00972486419041173 mirMAP -0.340393865717794 0.00632576765735203 NA NA NA hsa-miR-21-3p ZNF518A 3.50297439576639 6.39946844099206e-10 0.00151897063764839 0.997545199480392 MirTarget -0.158867140638315 0.00090156427500685 NA NA NA hsa-miR-106b-5p ZNF532 2.80565545918114 1.14547999022566e-09 -0.649960825484786 0.183521921069682 MirTarget -0.176407500796251 0.00268714602651028 NA NA NA hsa-miR-106b-5p ZNF561 2.80565545918114 1.14547999022566e-09 -0.555316803343846 0.164053839627157 mirMAP -0.170407301246463 0.000362511761041652 NA NA NA hsa-miR-15b-3p ZNF585B 3.57530146629867 5.89922785773482e-11 -1.11778647699861 0.234686469676017 mirMAP -0.281663191585593 0.00297058968103764 NA NA NA hsa-miR-21-3p ZNF652 3.50297439576639 6.39946844099206e-10 -0.430383932287781 0.191780331412849 MirTarget -0.142384091144836 6.86049847639162e-06 NA NA NA hsa-miR-15b-3p ZNF655 3.57530146629867 5.89922785773482e-11 -0.0736267378225479 0.84850821588209 mirMAP -0.123411328489442 0.00139338369380172 NA NA NA hsa-miR-15b-5p ZNF662 3.32329949959268 8.40210501034588e-13 -2.51592638809253 0.0467228011042057 MirTarget -0.365974433234484 0.0148421902176789 NA NA NA hsa-miR-21-5p ZNF667 2.65163477806992 6.72089787690756e-16 -3.55271263946821 0.011581039332447 miRNAWalker2_validate -0.759573357816391 0.00132943745016121 NA NA NA hsa-miR-15b-3p ZNF69 3.57530146629867 5.89922785773482e-11 -1.62820701629485 0.167830776227049 mirMAP -0.306395675052313 0.0102165974423152 NA NA NA hsa-miR-21-3p ZNF701 3.50297439576639 6.39946844099206e-10 -0.81175706573161 0.332110180980995 mirMAP -0.269116853873981 0.000939106388438263 NA NA NA hsa-miR-106b-5p ZNF704 2.80565545918114 1.14547999022566e-09 -2.29222962410485 0.0336148591878364 miRNATAP -0.501382878073386 0.000110981575929926 NA NA NA hsa-miR-15b-5p ZNF704 3.32329949959268 8.40210501034588e-13 -2.29222962410485 0.0336148591878364 MirTarget -0.378664155699029 0.00306024669240779 NA NA NA hsa-miR-21-5p ZNF704 2.65163477806992 6.72089787690756e-16 -2.29222962410485 0.0336148591878364 MirTarget;miRNATAP -0.489519291693527 0.0070175082296569 NA NA NA hsa-miR-21-3p ZNF772 3.50297439576639 6.39946844099206e-10 -2.60657405066085 0.0328229507958995 mirMAP -0.366500171424649 0.00211837756726251 NA NA NA hsa-miR-21-3p ZNF780B 3.50297439576639 6.39946844099206e-10 -0.870975541153797 0.073459979900563 mirMAP -0.234779421909053 5.10496184299725e-07 NA NA NA hsa-miR-106b-5p ZNF793 2.80565545918114 1.14547999022566e-09 -1.73900980947631 0.193665589907251 mirMAP -0.338998338709287 0.0362783898788075 NA NA NA hsa-miR-15b-3p ZNF793 3.57530146629867 5.89922785773482e-11 -1.73900980947631 0.193665589907251 mirMAP -0.487044429527429 0.000292466154305746 NA NA NA hsa-miR-15b-3p ZNF829 3.57530146629867 5.89922785773482e-11 -1.81930859872404 0.103591493888184 mirMAP -0.343944978057925 0.00228668990019248 NA NA NA hsa-miR-106b-5p ZNFX1 2.80565545918114 1.14547999022566e-09 -0.00478819624707061 0.989752994472624 MirTarget;miRNATAP -0.139610435321954 0.00176852725149154 NA NA NA hsa-miR-21-5p ZRANB1 2.65163477806992 6.72089787690756e-16 -1.01723103993304 0.000184538636978557 miRNAWalker2_validate -0.155941567832394 0.000622322668050664 NA NA NA hsa-miR-193a-3p ZSCAN18 0.646392169474854 0.207134343676122 -4.64396358940115 1.99946820424845e-06 miRanda -0.523881381331355 1.64248225931937e-06 NA NA NA hsa-miR-106b-5p ZSWIM4 2.80565545918114 1.14547999022566e-09 1.15774661104344 0.0141383449699791 mirMAP -0.184842247687574 0.0011504034676976 NA NA NA hsa-miR-21-3p ZYG11B 3.50297439576639 6.39946844099206e-10 -0.887188648993942 0.00135598411624428 MirTarget -0.126378501804011 2.12113665767143e-06 NA NA NA hsa-miR-21-5p ZYG11B 2.65163477806992 6.72089787690756e-16 -0.887188648993942 0.00135598411624428 miRNAWalker2_validate;mirMAP -0.128427811387905 0.00566070016453908 NA NA NA hsa-miR-15b-5p ZYX 3.32329949959268 8.40210501034588e-13 -2.27513839126864 2.49269395045846e-07 miRNATAP -0.293007838621638 1.85148476533578e-08 NA NA NA