miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-125a-5p APC 0.599529391575274 0.0102300147180307 -0.603984431450045 0.000122196213200349 miRanda -0.206850857172122 1.35649172215922e-10 NA NA NA hsa-miR-148a-3p APC 1.26728238710376 2.52325607402829e-06 -0.603984431450045 0.000122196213200349 miRNAWalker2_validate -0.118159804157767 2.41472154629156e-05 NA NA NA hsa-miR-186-5p APC 1.47445398888668 3.0781726595413e-15 -0.603984431450045 0.000122196213200349 miRNAWalker2_validate -0.195857780898061 7.35879611668229e-07 NA NA NA hsa-miR-21-5p APC 2.73773305747971 1.38864982139576e-43 -0.603984431450045 0.000122196213200349 miRNAWalker2_validate -0.210735008738127 9.09045679037576e-10 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-320a APC 0.438165828017084 0.0390159073347133 -0.603984431450045 0.000122196213200349 miRanda -0.103841534148773 0.00418426564639978 NA NA NA hsa-miR-338-3p APC 0.453166438193782 0.144583389707558 -0.603984431450045 0.000122196213200349 miRanda -0.108366079373357 9.49384870738723e-06 NA NA NA hsa-miR-501-3p APC 1.83132758513743 1.10971547702065e-10 -0.603984431450045 0.000122196213200349 TargetScan -0.113665798109815 1.4428194665465e-05 NA NA NA hsa-miR-590-3p APC 2.59289455139753 1.03200520972022e-21 -0.603984431450045 0.000122196213200349 PITA;miRanda;mirMAP;miRNATAP -0.100123284836768 0.0002767508066816 NA NA NA hsa-miR-103a-3p ARHGAP5 1.44083190496858 1.53799939616416e-13 -0.633864587619228 0.000468970281617145 MirTarget -0.10039051388481 0.0234119847988447 NA NA NA hsa-miR-126-5p ARHGAP5 0.895338176458417 2.33372756450713e-05 -0.633864587619228 0.000468970281617145 mirMAP -0.132932290503205 0.00136162798664299 NA NA NA hsa-miR-128-3p ARHGAP5 1.63756041666078 6.79626586407187e-14 -0.633864587619228 0.000468970281617145 miRNAWalker2_validate -0.123948583872317 0.00159757649372734 NA NA NA hsa-miR-155-5p ARHGAP5 1.20164021433135 0.00086170622431261 -0.633864587619228 0.000468970281617145 mirMAP -0.109878141052833 5.11938749128118e-06 NA NA NA hsa-miR-15a-5p ARHGAP5 2.34669284378787 1.69544424500258e-23 -0.633864587619228 0.000468970281617145 MirTarget;miRNATAP -0.136415581157063 0.000120187342256486 NA NA NA hsa-miR-16-1-3p ARHGAP5 2.56983217111073 3.02262181237943e-20 -0.633864587619228 0.000468970281617145 MirTarget -0.101885063357298 0.00100016172229752 NA NA NA hsa-miR-16-2-3p ARHGAP5 2.31623086727196 4.29838149388188e-20 -0.633864587619228 0.000468970281617145 mirMAP -0.115365600131629 0.000538337375724232 NA NA NA hsa-miR-17-5p ARHGAP5 3.2710598467455 9.93128340539455e-27 -0.633864587619228 0.000468970281617145 miRNAWalker2_validate -0.126798958122877 2.25035983320949e-06 NA NA NA hsa-miR-181a-5p ARHGAP5 2.29556023480783 1.8138457900616e-21 -0.633864587619228 0.000468970281617145 mirMAP -0.204518285975318 2.44240598362648e-09 NA NA NA hsa-miR-181b-5p ARHGAP5 2.49307679431293 3.92829250217627e-20 -0.633864587619228 0.000468970281617145 mirMAP -0.129483067256506 2.71936961558074e-05 NA NA NA hsa-miR-181c-5p ARHGAP5 1.58587920618301 1.57506918816933e-10 -0.633864587619228 0.000468970281617145 mirMAP -0.156871764126297 5.89516703053114e-06 NA NA NA hsa-miR-186-5p ARHGAP5 1.47445398888668 3.0781726595413e-15 -0.633864587619228 0.000468970281617145 MirTarget;miRNATAP -0.242536792434313 9.53231855578356e-08 NA NA NA hsa-miR-18a-5p ARHGAP5 3.78535678765353 3.72446596213886e-26 -0.633864587619228 0.000468970281617145 MirTarget -0.133318514088219 3.15354289403671e-08 NA NA NA hsa-miR-19a-3p ARHGAP5 3.42309334186656 3.02671914353412e-28 -0.633864587619228 0.000468970281617145 miRNATAP -0.163437428194043 3.3225693711099e-10 NA NA NA hsa-miR-19b-3p ARHGAP5 2.49529833021187 1.57028265846699e-23 -0.633864587619228 0.000468970281617145 miRNATAP -0.186214496341708 1.69348057280202e-08 NA NA NA hsa-miR-218-5p ARHGAP5 -0.573801507392184 0.0551983860126703 -0.633864587619228 0.000468970281617145 miRNATAP -0.13660675398763 2.90363462337261e-06 NA NA NA hsa-miR-26b-5p ARHGAP5 0.885393662798425 3.2116297961629e-06 -0.633864587619228 0.000468970281617145 MirTarget;mirMAP -0.100108237984097 0.0309695360210526 NA NA NA hsa-miR-374a-5p ARHGAP5 0.484615721953736 0.0042981729815149 -0.633864587619228 0.000468970281617145 mirMAP -0.188952165897169 0.000308584807722271 NA NA NA hsa-miR-374b-5p ARHGAP5 0.0654362503857184 0.722673188879465 -0.633864587619228 0.000468970281617145 mirMAP;miRNATAP -0.141045991971381 0.00357439508178987 NA NA NA hsa-miR-409-5p ARHGAP5 1.56949123847358 5.91654175754272e-07 -0.633864587619228 0.000468970281617145 PITA -0.119147589501975 4.38723491908954e-05 NA NA NA hsa-miR-484 ARHGAP5 1.81844463411787 1.82951571230938e-15 -0.633864587619228 0.000468970281617145 miRNATAP -0.154245118578898 3.35326290197834e-05 NA NA NA hsa-miR-497-5p ARHGAP5 0.0257087130056286 0.918145413833358 -0.633864587619228 0.000468970281617145 MirTarget;miRNATAP -0.145753905139861 3.48835473078848e-05 NA NA NA hsa-miR-500a-5p ARHGAP5 1.72110365584658 3.0807246212659e-10 -0.633864587619228 0.000468970281617145 mirMAP -0.149787032259398 1.78433026824573e-06 NA NA NA hsa-miR-501-5p ARHGAP5 1.93654809410041 1.3779381780759e-10 -0.633864587619228 0.000468970281617145 PITA;mirMAP -0.138420337297353 2.09581200272753e-06 NA NA NA hsa-miR-576-5p ARHGAP5 2.20467023993664 3.4053475193793e-19 -0.633864587619228 0.000468970281617145 MirTarget;PITA -0.16460379173756 1.31378432763908e-06 NA NA NA hsa-miR-590-3p ARHGAP5 2.59289455139753 1.03200520972022e-21 -0.633864587619228 0.000468970281617145 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.116794291778389 0.000230588020356184 NA NA NA hsa-miR-590-5p ARHGAP5 3.18300989862077 2.06813568597893e-26 -0.633864587619228 0.000468970281617145 miRanda -0.129638484811844 4.22005603935349e-06 NA NA NA hsa-miR-655-3p ARHGAP5 0.485339318272148 0.137014658258732 -0.633864587619228 0.000468970281617145 MirTarget -0.110365359487528 5.41044962006368e-05 NA NA NA hsa-let-7a-3p AXIN2 1.42015538786275 7.03375209382654e-13 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.580881072981708 7.52786609329052e-09 NA NA NA hsa-let-7b-3p AXIN2 0.868207752019623 1.30460056774366e-05 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.466094148302635 5.47361078751581e-06 NA NA NA hsa-let-7g-3p AXIN2 3.26398061402445 3.96263126107645e-25 -1.6986287186272 5.56904404371908e-05 MirTarget -0.333037817887653 9.55083906918248e-08 NA NA NA hsa-miR-103a-3p AXIN2 1.44083190496858 1.53799939616416e-13 -1.6986287186272 5.56904404371908e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.432944543888631 2.49508578477517e-05 NA NA NA hsa-miR-107 AXIN2 1.30977326593435 1.30372468603965e-11 -1.6986287186272 5.56904404371908e-05 miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.497419239480003 1.65377519483307e-06 26191213 miR 107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2; At the molecular level our results suggested that expression of Axin2 was negatively regulated by miR-107; Our observations suggested that miR-107 could promote HCC cells proliferation via targeting Axin2 and might represent a potential therapeutic target for HCC liver cancer hsa-miR-144-3p AXIN2 0.658119849508907 0.146943823997989 -1.6986287186272 5.56904404371908e-05 MirTarget -0.271648120794949 3.48662016244501e-09 NA NA NA hsa-miR-15a-5p AXIN2 2.34669284378787 1.69544424500258e-23 -1.6986287186272 5.56904404371908e-05 MirTarget;miRNATAP -0.480955940416503 4.33519973886455e-09 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 1.57112623124278 9.14247846750597e-13 -1.6986287186272 5.56904404371908e-05 miRTarBase;MirTarget;miRNATAP -0.560514974548682 4.5066035821598e-10 NA NA NA hsa-miR-16-2-3p AXIN2 2.31623086727196 4.29838149388188e-20 -1.6986287186272 5.56904404371908e-05 mirMAP -0.591252000994373 5.59406157801316e-15 NA NA NA hsa-miR-16-5p AXIN2 1.75824877145857 1.68592440033108e-16 -1.6986287186272 5.56904404371908e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.751187601216971 8.49686809333106e-17 NA NA NA hsa-miR-205-5p AXIN2 4.1389800495524 2.05488295686453e-12 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.215833874277093 8.14436018934996e-11 NA NA NA hsa-miR-221-3p AXIN2 0.451556679024397 0.0909808299917811 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.245163690159045 0.00148170922010665 NA NA NA hsa-miR-222-3p AXIN2 0.851783756239071 0.00266783568486918 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.319516992304074 8.90127082603084e-06 NA NA NA hsa-miR-26b-3p AXIN2 2.18464160365372 2.11543189388328e-18 -1.6986287186272 5.56904404371908e-05 MirTarget -0.484074743403874 5.01575452903022e-10 NA NA NA hsa-miR-29a-5p AXIN2 1.46749674755271 3.34605004270294e-07 -1.6986287186272 5.56904404371908e-05 MirTarget -0.371370756814131 5.27889012104867e-07 NA NA NA hsa-miR-34a-5p AXIN2 1.9016323452565 1.43092834643601e-14 -1.6986287186272 5.56904404371908e-05 miRNAWalker2_validate;miRTarBase -0.316389522899683 8.52056660674017e-05 23624843 p53 regulates nuclear GSK 3 levels through miR 34 mediated Axin2 suppression in colorectal cancer cells; Exogenous miR-34a decreases Axin2 UTR-reporter activity through multiple binding sites within the 5' and 3' UTR of Axin2; Further RNA transcripts of miR-34 target were correlated with Axin2 in clinical data set of colorectal cancer patients colorectal cancer hsa-miR-3614-5p AXIN2 2.17736331059655 2.19144831318484e-08 -1.6986287186272 5.56904404371908e-05 MirTarget;miRNATAP -0.268139148154882 4.79077962415622e-07 NA NA NA hsa-miR-424-5p AXIN2 1.61930224569578 1.89642549274994e-10 -1.6986287186272 5.56904404371908e-05 MirTarget;miRNATAP -0.26417909926508 0.000864498183223041 NA NA NA hsa-miR-429 AXIN2 4.48815175680773 2.44117492218206e-17 -1.6986287186272 5.56904404371908e-05 miRanda -0.108406747689685 0.00354861851668096 NA NA NA hsa-miR-590-3p AXIN2 2.59289455139753 1.03200520972022e-21 -1.6986287186272 5.56904404371908e-05 MirTarget;PITA;miRanda;miRNATAP -0.47289600145345 8.55966813825129e-11 NA NA NA hsa-miR-592 AXIN2 1.51765968871077 0.000636335248013204 -1.6986287186272 5.56904404371908e-05 MirTarget -0.111587883837953 0.0174338833138119 NA NA NA hsa-miR-944 AXIN2 2.91186649218281 1.31574753528144e-06 -1.6986287186272 5.56904404371908e-05 MirTarget;PITA;miRNATAP -0.201429219843121 4.01001036442831e-09 NA NA NA hsa-miR-101-3p BIRC5 0.522819989585461 0.00375627731618038 3.86781496994262 3.62815734924518e-31 miRNAWalker2_validate -0.215833533283252 0.026958101653947 NA NA NA hsa-miR-10a-5p BIRC5 1.15016989191194 0.00372037233992369 3.86781496994262 3.62815734924518e-31 miRNAWalker2_validate -0.122559917660219 0.00501323157348866 NA NA NA hsa-miR-139-5p BUB1 -1.52606598644743 1.20474151350665e-08 2.99497420874398 2.90503661450991e-26 miRanda -0.245529252241127 3.91470133994434e-06 NA NA NA hsa-miR-30b-5p CCNA1 0.800822374912712 0.000133601914525413 -0.799524339575412 0.295283787863684 MirTarget -0.432860978017981 0.0143351697868655 NA NA NA hsa-miR-30c-5p CCNA1 0.778774633108 0.000285599212429136 -0.799524339575412 0.295283787863684 MirTarget -0.758549977409093 9.50998783716041e-06 NA NA NA hsa-miR-30d-5p CCNA1 0.675423997639582 0.00270618816039773 -0.799524339575412 0.295283787863684 MirTarget -1.00433531983321 5.2492230769758e-10 NA NA NA hsa-miR-30e-5p CCNA1 1.23904909539663 1.35561917122157e-09 -0.799524339575412 0.295283787863684 MirTarget -0.832005732765763 2.71456932387536e-06 NA NA NA hsa-miR-320a CCNA1 0.438165828017084 0.0390159073347133 -0.799524339575412 0.295283787863684 miRanda -0.361645889379044 0.0396491980849408 NA NA NA hsa-miR-335-5p CCNA1 1.77247705492746 2.22457658872091e-06 -0.799524339575412 0.295283787863684 miRNAWalker2_validate -0.252904547371949 0.0095171880094844 NA NA NA hsa-miR-218-5p CCNA2 -0.573801507392184 0.0551983860126703 2.81251184571189 1.99970506215583e-25 MirTarget -0.145050755643329 0.00176557013722416 NA NA NA hsa-miR-29c-3p CCNA2 -0.00968972577705429 0.97099586346872 2.81251184571189 1.99970506215583e-25 MirTarget -0.340911968917063 2.88619895890886e-11 NA NA NA hsa-miR-139-5p CCNB1 -1.52606598644743 1.20474151350665e-08 2.5876663861041 1.47856299409004e-23 miRanda -0.228760920591688 2.21107834979824e-06 NA NA NA hsa-miR-23b-3p CDC20 -0.251132426825047 0.150200321210792 3.88984891303216 1.21088023421357e-31 miRNAWalker2_validate -0.444513507865143 9.49371726362108e-06 NA NA NA hsa-miR-30a-5p CDC20 -0.878357906436456 0.000509952992366057 3.88984891303216 1.21088023421357e-31 miRNAWalker2_validate -0.143618820789461 0.0368813303219935 NA NA NA hsa-miR-139-5p CDH1 -1.52606598644743 1.20474151350665e-08 2.70562342616265 1.9661369341111e-09 PITA;miRanda -0.255426475960002 0.00180924947364428 NA NA NA hsa-miR-146b-5p CDH1 1.75587235896724 1.15724631266659e-07 2.70562342616265 1.9661369341111e-09 miRanda -0.160334471060472 0.0156097318769976 NA NA NA hsa-miR-338-3p CDH1 0.453166438193782 0.144583389707558 2.70562342616265 1.9661369341111e-09 MirTarget;miRanda -0.143703854215043 0.0457714257088257 NA NA NA hsa-miR-139-5p CDK1 -1.52606598644743 1.20474151350665e-08 3.39379878049959 1.23629696548947e-37 miRanda -0.237475763302247 3.67483206781614e-06 NA NA NA hsa-miR-195-3p CDK1 -0.658653229922836 0.0142127125129199 3.39379878049959 1.23629696548947e-37 MirTarget -0.206546617532073 9.89648235471957e-05 NA NA NA hsa-miR-23b-3p CDK2 -0.251132426825047 0.150200321210792 0.937881089752417 5.53579780631165e-08 miRNAWalker2_validate -0.108170361258168 0.0284026530581814 NA NA NA hsa-miR-221-3p CDKN1B 0.451556679024397 0.0909808299917811 0.111589542072177 0.453851218822883 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.108173416521144 5.5134677794152e-05 23637992;19953484;23939688;19126397;20146005;23967190;17569667;22992757;17721077;20461750 miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression progression;;;;staging;tumorigenesis;;;;;poor survival breast cancer;glioblastoma;breast cancer;melanoma;liver cancer;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-24-3p CDKN1B 0.99989036772428 1.35595013650376e-07 0.111589542072177 0.453851218822883 miRNAWalker2_validate;miRNATAP -0.155773035071718 3.27990988982606e-05 26847530;26044523 The biological significance of miR-24 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets p27 CDKN1B and p16 CDK2NA was investigated;With the bioinformatic method we further identified that p27Kip1 is a direct target of miR-24-3p and its protein level was negatively regulated by miR-24-3p ; prostate cancer;breast cancer hsa-miR-125a-5p CDKN2B 0.599529391575274 0.0102300147180307 -0.112970149969128 0.832353274540521 miRanda -0.310089305986085 0.00518147219807009 NA NA NA hsa-miR-28-5p CDKN2B 0.230152919654905 0.0742909586754846 -0.112970149969128 0.832353274540521 miRanda -0.668331542152576 0.00118921247732729 NA NA NA hsa-miR-330-3p CDKN2B 0.876747334239085 0.00073709016089703 -0.112970149969128 0.832353274540521 mirMAP;miRNATAP -0.269857955336921 0.0065388859673795 NA NA NA hsa-miR-335-3p CDKN2B 3.08791651139852 5.31309869723517e-12 -0.112970149969128 0.832353274540521 mirMAP -0.121455967054073 0.0304992894193917 NA NA NA hsa-miR-582-5p CDKN2B 0.609226359812689 0.032988717891497 -0.112970149969128 0.832353274540521 miRNATAP -0.437780407212853 1.01848865191063e-06 NA NA NA hsa-miR-671-5p CDKN2B 2.97733652243246 1.21148452344738e-23 -0.112970149969128 0.832353274540521 PITA -0.427729850509145 6.77528914607289e-07 NA NA NA hsa-miR-944 CDKN2B 2.91186649218281 1.31574753528144e-06 -0.112970149969128 0.832353274540521 mirMAP;miRNATAP -0.216243202750685 5.52569916158531e-07 NA NA NA hsa-miR-182-5p CDKN2C 3.53923166221814 5.07781258121574e-21 0.22688212352847 0.433133415352322 MirTarget -0.132415467904401 0.00017052034340074 NA NA NA hsa-miR-34a-5p CDKN2C 1.9016323452565 1.43092834643601e-14 0.22688212352847 0.433133415352322 miRNAWalker2_validate -0.218709270480303 6.47001667111707e-05 NA NA NA hsa-miR-29b-2-5p CHUK 0.910668640983475 0.00666655585493488 -0.123960303858583 0.302722046952969 MirTarget -0.105463511044412 4.36313837727314e-10 NA NA NA hsa-miR-497-5p CHUK 0.0257087130056286 0.918145413833358 -0.123960303858583 0.302722046952969 MirTarget -0.130303574602807 1.33264117705817e-08 NA NA NA hsa-miR-197-3p COL4A6 1.75733174019505 8.88576793100499e-13 -2.86000294682833 8.37273620398162e-07 miRNAWalker2_validate -0.654832103652115 4.04778714168634e-09 NA NA NA hsa-miR-326 COL4A6 0.715313016136042 0.0610265683213359 -2.86000294682833 8.37273620398162e-07 miRanda -0.428482353854255 6.08458619098456e-09 NA NA NA hsa-miR-342-3p COL4A6 1.49115144672245 1.43879249744621e-07 -2.86000294682833 8.37273620398162e-07 miRanda -0.48884805502412 6.4676784510391e-07 NA NA NA hsa-miR-429 COL4A6 4.48815175680773 2.44117492218206e-17 -2.86000294682833 8.37273620398162e-07 miRanda;miRNATAP -0.171292420502726 0.000858134920060823 NA NA NA hsa-miR-590-3p COL4A6 2.59289455139753 1.03200520972022e-21 -2.86000294682833 8.37273620398162e-07 miRanda -0.565460375775464 2.54437761203123e-08 NA NA NA hsa-miR-96-5p COL4A6 4.89433085814374 1.92000659886961e-31 -2.86000294682833 8.37273620398162e-07 TargetScan -0.27846705536655 1.38871365657908e-05 NA NA NA hsa-miR-125a-3p CSF2RA 1.24490295132072 5.26925231010328e-06 -0.4553523853558 0.336459148012398 miRanda -0.168864337098838 0.0430562220811156 NA NA NA hsa-miR-129-5p CSF2RA -0.524170159980738 0.222582956006346 -0.4553523853558 0.336459148012398 mirMAP -0.184762146282875 0.000655202573807057 NA NA NA hsa-miR-330-5p CSF2RA 1.15100069700871 4.85551805046014e-07 -0.4553523853558 0.336459148012398 miRanda -0.250267527777727 0.011953315853783 NA NA NA hsa-miR-361-5p CSF2RA 0.971859117235239 5.30236555707088e-09 -0.4553523853558 0.336459148012398 miRanda -0.99144303897371 1.15548302893588e-13 NA NA NA hsa-miR-429 CSF2RA 4.48815175680773 2.44117492218206e-17 -0.4553523853558 0.336459148012398 miRanda -0.316749360663251 2.98906853937265e-15 NA NA NA hsa-miR-590-3p CSF2RA 2.59289455139753 1.03200520972022e-21 -0.4553523853558 0.336459148012398 mirMAP -0.170659500979583 0.0397705881080091 NA NA NA hsa-miR-28-5p CTNNB1 0.230152919654905 0.0742909586754846 -0.220922161177096 0.11826020711692 miRanda -0.182072912507331 0.000829385072717343 NA NA NA hsa-miR-125a-5p EGFR 0.599529391575274 0.0102300147180307 -0.229170429190265 0.593897211976523 mirMAP -0.455142512240812 2.58435389092739e-07 19881956;27094723;24484870 We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3;Suppression of microRNA 125a 5p upregulates the TAZ EGFR signaling pathway and promotes retinoblastoma proliferation; Moreover the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo; Finally TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation; Taken together our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma;miR 125a regulates cell cycle proliferation and apoptosis by targeting the ErbB pathway in acute myeloid leukemia; Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a; Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML ;progression;progression ovarian cancer;retinoblastoma;acute myeloid leukemia hsa-miR-128-3p EGFR 1.63756041666078 6.79626586407187e-14 -0.229170429190265 0.593897211976523 miRNAWalker2_validate;miRTarBase -0.202545235408722 0.029374382947331 NA NA NA hsa-miR-140-5p EGFR 0.844753502512594 3.73722278438606e-05 -0.229170429190265 0.593897211976523 miRanda -0.290336016621899 0.00422174515988415 NA NA NA hsa-miR-148b-5p EGFR 2.18024067300781 2.84770452413262e-14 -0.229170429190265 0.593897211976523 mirMAP -0.287604854162764 0.000103760310070035 NA NA NA hsa-miR-17-5p EGFR 3.2710598467455 9.93128340539455e-27 -0.229170429190265 0.593897211976523 TargetScan -0.128743012821673 0.0441608856474895 NA NA NA hsa-miR-186-5p EGFR 1.47445398888668 3.0781726595413e-15 -0.229170429190265 0.593897211976523 mirMAP -0.330064150409367 0.0023537398913317 NA NA NA hsa-miR-192-5p EGFR 2.69002528723195 1.22990188194432e-16 -0.229170429190265 0.593897211976523 mirMAP -0.142745422121227 0.0206689451740369 NA NA NA hsa-miR-195-3p EGFR -0.658653229922836 0.0142127125129199 -0.229170429190265 0.593897211976523 mirMAP -0.161748110776139 0.0406071095905996 24282590 Plasma levels of miR-195 and miR-122 expression were also associated with overall survival in the patients especially in those with advanced stage HR=0.23 95%CI:0.07-0.84; and HR=0.22 95%CI:0.06-0.77 and EGFR mutation HR=0.27 95%CI:0.08-0.96; and HR=0.23 95%CI=0.06-0.81; Circulating miR-195 and miR-122 may have prognostic values in predicting the overall survival as well as predicting EGFR mutation status in non-smoking female patients with lung adenocarcinoma; Measuring plasma levels of miR-195 and miR-122 may especially be useful in EGFR mutant patients with lung adenocarcinoma staging;poor survival lung cancer hsa-miR-200a-3p EGFR 4.59434485520731 6.38952518573476e-18 -0.229170429190265 0.593897211976523 MirTarget -0.167369688006813 6.24721098372953e-06 19671845;26184032 Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells;MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion ;drug resistance;cell migration bladder cancer;lung squamous cell cancer hsa-miR-29b-2-5p EGFR 0.910668640983475 0.00666655585493488 -0.229170429190265 0.593897211976523 mirMAP -0.416042511145117 5.70054998722675e-12 NA NA NA hsa-miR-30d-3p EGFR 0.977747550180601 4.3048212205381e-05 -0.229170429190265 0.593897211976523 mirMAP -0.297777237144485 0.000583685262316395 NA NA NA hsa-miR-30e-3p EGFR -0.215663037684509 0.235375122783546 -0.229170429190265 0.593897211976523 mirMAP -0.258675937752403 0.025934094827771 NA NA NA hsa-miR-32-3p EGFR 2.02436999565685 5.94091197945307e-09 -0.229170429190265 0.593897211976523 mirMAP -0.140511240373734 0.0362137719766625 NA NA NA hsa-miR-320a EGFR 0.438165828017084 0.0390159073347133 -0.229170429190265 0.593897211976523 miRanda;mirMAP -0.237441545432742 0.0161714500455112 NA NA NA hsa-miR-335-5p EGFR 1.77247705492746 2.22457658872091e-06 -0.229170429190265 0.593897211976523 miRNAWalker2_validate -0.107777488168613 0.0497360336107625 NA NA NA hsa-miR-342-3p EGFR 1.49115144672245 1.43879249744621e-07 -0.229170429190265 0.593897211976523 miRanda -0.145868494821454 0.0444309022820605 NA NA NA hsa-miR-362-5p EGFR 1.59303749908759 9.582675908797e-08 -0.229170429190265 0.593897211976523 mirMAP -0.241167685764662 0.00042775566379085 NA NA NA hsa-miR-374a-3p EGFR 0.533309330504947 0.00192918429705142 -0.229170429190265 0.593897211976523 mirMAP -0.472580799180365 0.000102592756227524 NA NA NA hsa-miR-374b-3p EGFR 0.930487774873495 2.74420094310516e-05 -0.229170429190265 0.593897211976523 mirMAP -0.31457186042627 0.000782176493255895 NA NA NA hsa-miR-3913-5p EGFR 2.44353493655328 8.95279496632448e-15 -0.229170429190265 0.593897211976523 mirMAP -0.259753924250973 7.19865795250564e-05 NA NA NA hsa-miR-7-1-3p EGFR 1.84950311431067 1.25300363397654e-13 -0.229170429190265 0.593897211976523 mirMAP -0.211992850385644 0.00900776269242333 NA NA NA hsa-miR-769-5p EGFR 1.82023760596845 9.6815886564134e-14 -0.229170429190265 0.593897211976523 mirMAP -0.205393584719106 0.0132200012753408 NA NA NA hsa-miR-126-5p EGLN1 0.895338176458417 2.33372756450713e-05 -0.389002254751033 0.00250237629339543 mirMAP -0.122920804077538 2.57867637447396e-05 NA NA NA hsa-miR-181b-5p EGLN1 2.49307679431293 3.92829250217627e-20 -0.389002254751033 0.00250237629339543 mirMAP -0.113937317312115 1.491418900667e-07 NA NA NA hsa-miR-186-5p EGLN1 1.47445398888668 3.0781726595413e-15 -0.389002254751033 0.00250237629339543 mirMAP -0.140456140536497 1.38398464868509e-05 NA NA NA hsa-miR-24-1-5p EGLN1 0.333970971402977 0.135651278931933 -0.389002254751033 0.00250237629339543 MirTarget -0.120017223138365 1.61380752482172e-05 NA NA NA hsa-miR-1180-3p ETS1 1.89089238665533 6.0740017059558e-10 -0.699528618233348 0.00228038287696191 MirTarget -0.244121354774836 2.55157060576529e-12 NA NA NA hsa-miR-130b-5p ETS1 2.9963110846538 1.98883029416455e-18 -0.699528618233348 0.00228038287696191 MirTarget -0.197851115362848 3.09455981925009e-10 NA NA NA hsa-miR-141-3p ETS1 5.02396127982626 2.19224509139725e-24 -0.699528618233348 0.00228038287696191 mirMAP -0.136403222013607 5.63450066135883e-11 NA NA NA hsa-miR-141-5p ETS1 3.81419396518882 3.21977359736126e-18 -0.699528618233348 0.00228038287696191 mirMAP -0.123976156597553 2.49253154344744e-07 NA NA NA hsa-miR-148b-5p ETS1 2.18024067300781 2.84770452413262e-14 -0.699528618233348 0.00228038287696191 MirTarget -0.207990667795076 1.28931361643613e-07 NA NA NA hsa-miR-16-1-3p ETS1 2.56983217111073 3.02262181237943e-20 -0.699528618233348 0.00228038287696191 MirTarget -0.122165585835548 0.00181706646615353 NA NA NA hsa-miR-181c-5p ETS1 1.58587920618301 1.57506918816933e-10 -0.699528618233348 0.00228038287696191 MirTarget;miRNATAP -0.175149607451902 6.6152939086479e-05 NA NA NA hsa-miR-181d-5p ETS1 1.52204912185579 9.2693319057748e-08 -0.699528618233348 0.00228038287696191 MirTarget -0.194031987778554 3.77300921536723e-07 NA NA NA hsa-miR-186-5p ETS1 1.47445398888668 3.0781726595413e-15 -0.699528618233348 0.00228038287696191 mirMAP -0.237100721837613 4.18170175987953e-05 NA NA NA hsa-miR-193b-3p ETS1 2.25711804611899 4.1940744806631e-14 -0.699528618233348 0.00228038287696191 miRNAWalker2_validate;miRTarBase -0.116182318208838 0.00128795484233059 20655737 CCND1 and ETS1 were revealed to be regulated by miR-193b directly liver cancer hsa-miR-200a-3p ETS1 4.59434485520731 6.38952518573476e-18 -0.699528618233348 0.00228038287696191 mirMAP -0.130762918379965 2.32449200300814e-11 NA NA NA hsa-miR-200b-3p ETS1 3.78235093249346 3.18343003239465e-14 -0.699528618233348 0.00228038287696191 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.126548351947289 2.52221854075541e-09 NA NA NA hsa-miR-200c-3p ETS1 3.50132673580082 2.42716349086937e-15 -0.699528618233348 0.00228038287696191 MirTarget;miRNATAP -0.128822600745719 7.61112410894651e-08 NA NA NA hsa-miR-3065-5p ETS1 2.74629919868982 1.86846589298284e-08 -0.699528618233348 0.00228038287696191 MirTarget;miRNATAP -0.193575116122862 4.45006309422286e-13 NA NA NA hsa-miR-30d-3p ETS1 0.977747550180601 4.3048212205381e-05 -0.699528618233348 0.00228038287696191 mirMAP -0.170400392397335 0.000235272019902835 NA NA NA hsa-miR-320b ETS1 1.55692969039548 1.41071034251915e-08 -0.699528618233348 0.00228038287696191 miRanda -0.149437856303236 0.000174923330597169 NA NA NA hsa-miR-34a-3p ETS1 1.75590866103657 8.02801510630657e-09 -0.699528618233348 0.00228038287696191 MirTarget -0.130153884614291 0.00111725955210861 NA NA NA hsa-miR-421 ETS1 1.17791565395543 6.78526676976629e-06 -0.699528618233348 0.00228038287696191 miRanda;mirMAP;miRNATAP -0.172317840126905 4.29884721227258e-05 NA NA NA hsa-miR-429 ETS1 4.48815175680773 2.44117492218206e-17 -0.699528618233348 0.00228038287696191 MirTarget;PITA;miRanda;miRNATAP -0.120719223989231 1.04596955789957e-09 NA NA NA hsa-miR-491-5p ETS1 0.615770352820862 0.0418295628761654 -0.699528618233348 0.00228038287696191 miRanda -0.10782348524909 0.00633079706572199 NA NA NA hsa-miR-501-5p ETS1 1.93654809410041 1.3779381780759e-10 -0.699528618233348 0.00228038287696191 mirMAP -0.139135103900185 0.000174783639360326 NA NA NA hsa-miR-532-3p ETS1 1.96631878320218 4.53421954361695e-13 -0.699528618233348 0.00228038287696191 MirTarget;PITA;miRNATAP -0.199441489908224 4.45954107263149e-07 NA NA NA hsa-miR-576-5p ETS1 2.20467023993664 3.4053475193793e-19 -0.699528618233348 0.00228038287696191 mirMAP -0.130355258248144 0.00265911186248793 NA NA NA hsa-miR-590-3p ETS1 2.59289455139753 1.03200520972022e-21 -0.699528618233348 0.00228038287696191 PITA;miRanda;mirMAP -0.102509106812931 0.0108961648020238 NA NA NA hsa-miR-590-5p ETS1 3.18300989862077 2.06813568597893e-26 -0.699528618233348 0.00228038287696191 miRanda -0.158651775088276 8.61652325410999e-06 NA NA NA hsa-miR-660-5p ETS1 1.82692095272076 1.92040083607196e-13 -0.699528618233348 0.00228038287696191 MirTarget -0.134835635879403 0.00199931863083817 NA NA NA hsa-miR-7-1-3p ETS1 1.84950311431067 1.25300363397654e-13 -0.699528618233348 0.00228038287696191 mirMAP -0.139989009171827 0.00125234618495247 NA NA NA hsa-miR-769-5p ETS1 1.82023760596845 9.6815886564134e-14 -0.699528618233348 0.00228038287696191 miRNATAP -0.245118089805823 2.10373211221653e-08 NA NA NA hsa-miR-9-5p ETS1 1.02304182473283 0.042901377604859 -0.699528618233348 0.00228038287696191 miRNAWalker2_validate;miRTarBase;miRNATAP -0.102192436372206 2.67091472704971e-06 NA NA NA hsa-miR-940 ETS1 3.21011374578759 2.7923171128495e-14 -0.699528618233348 0.00228038287696191 MirTarget;miRNATAP -0.149836494354828 5.13213847318185e-08 NA NA NA hsa-miR-942-5p ETS1 2.35195531153712 5.45059325728841e-16 -0.699528618233348 0.00228038287696191 MirTarget -0.100342268781321 0.00675183151347448 NA NA NA hsa-let-7a-3p FGF2 1.42015538786275 7.03375209382654e-13 -3.45935256477983 3.20406041037898e-17 mirMAP -0.57039623316549 1.64408016446008e-08 NA NA NA hsa-let-7b-3p FGF2 0.868207752019623 1.30460056774366e-05 -3.45935256477983 3.20406041037898e-17 mirMAP -0.530485029047925 2.33230657638534e-07 NA NA NA hsa-let-7f-1-3p FGF2 1.55054488387679 7.31326775537952e-11 -3.45935256477983 3.20406041037898e-17 mirMAP -0.403619323347166 3.50383349222099e-06 NA NA NA hsa-miR-103a-3p FGF2 1.44083190496858 1.53799939616416e-13 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.951198901738798 5.80167380051094e-22 NA NA NA hsa-miR-107 FGF2 1.30977326593435 1.30372468603965e-11 -3.45935256477983 3.20406041037898e-17 MirTarget;PITA;miRanda;miRNATAP -0.746537045946991 3.12339725479843e-13 NA NA NA hsa-miR-10b-3p FGF2 0.77597971642517 0.00264877454133753 -3.45935256477983 3.20406041037898e-17 mirMAP -0.38765486044307 1.00531657460278e-06 NA NA NA hsa-miR-1226-3p FGF2 1.38118928579963 0.000205503474787488 -3.45935256477983 3.20406041037898e-17 MirTarget -0.406312709645584 4.86442323802081e-11 NA NA NA hsa-miR-126-5p FGF2 0.895338176458417 2.33372756450713e-05 -3.45935256477983 3.20406041037898e-17 mirMAP -0.221461498102424 0.0233691135465993 NA NA NA hsa-miR-144-3p FGF2 0.658119849508907 0.146943823997989 -3.45935256477983 3.20406041037898e-17 MirTarget -0.150660886736508 0.00130127640996876 NA NA NA hsa-miR-148a-5p FGF2 1.16173838132242 0.000148929299881612 -3.45935256477983 3.20406041037898e-17 mirMAP -0.175801486236704 0.00879070967495281 NA NA NA hsa-miR-15a-5p FGF2 2.34669284378787 1.69544424500258e-23 -3.45935256477983 3.20406041037898e-17 MirTarget;miRNATAP -0.8665754259228 1.51865052824555e-28 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 2.33847028227712 4.29662877950836e-19 -3.45935256477983 3.20406041037898e-17 mirMAP -0.698237395560323 2.98047943363042e-22 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 1.57112623124278 9.14247846750597e-13 -3.45935256477983 3.20406041037898e-17 MirTarget;miRNATAP -0.772339849603923 2.2379572945642e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 2.56983217111073 3.02262181237943e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.706717215195114 8.84760087286705e-25 NA NA NA hsa-miR-16-2-3p FGF2 2.31623086727196 4.29838149388188e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.642959805706348 1.63529117433717e-17 NA NA NA hsa-miR-16-5p FGF2 1.75824877145857 1.68592440033108e-16 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.791482784689716 1.7414135213028e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-181a-5p FGF2 2.29556023480783 1.8138457900616e-21 -3.45935256477983 3.20406041037898e-17 mirMAP -0.525450431942733 5.3421915793276e-11 NA NA NA hsa-miR-181b-5p FGF2 2.49307679431293 3.92829250217627e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.487813576366985 7.1537699850524e-12 NA NA NA hsa-miR-181c-5p FGF2 1.58587920618301 1.57506918816933e-10 -3.45935256477983 3.20406041037898e-17 mirMAP -0.402853563332211 6.66481994248428e-07 NA NA NA hsa-miR-186-5p FGF2 1.47445398888668 3.0781726595413e-15 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;mirMAP -0.865396245604199 9.71640315277788e-17 NA NA NA hsa-miR-192-5p FGF2 2.69002528723195 1.22990188194432e-16 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.55945113419736 8.27439417486679e-22 NA NA NA hsa-miR-19b-1-5p FGF2 2.57951428759379 4.31576118703427e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.684742945615863 1.47856020889472e-23 NA NA NA hsa-miR-200b-3p FGF2 3.78235093249346 3.18343003239465e-14 -3.45935256477983 3.20406041037898e-17 mirMAP -0.442848247331966 6.36624370256829e-33 NA NA NA hsa-miR-200c-3p FGF2 3.50132673580082 2.42716349086937e-15 -3.45935256477983 3.20406041037898e-17 mirMAP -0.581898672989235 1.2281612826909e-47 NA NA NA hsa-miR-20a-3p FGF2 2.92621109947706 2.49504904635375e-17 -3.45935256477983 3.20406041037898e-17 mirMAP -0.521338868643764 2.37178789361296e-20 NA NA NA hsa-miR-21-3p FGF2 2.19296355304364 4.63665722759779e-15 -3.45935256477983 3.20406041037898e-17 mirMAP -0.389762818312192 3.3064358783093e-08 NA NA NA hsa-miR-21-5p FGF2 2.73773305747971 1.38864982139576e-43 -3.45935256477983 3.20406041037898e-17 mirMAP -0.590129232102637 2.05709217680526e-10 NA NA NA hsa-miR-215-5p FGF2 2.30755467422978 2.38476032118039e-06 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.234704807386955 3.03139328926694e-08 NA NA NA hsa-miR-29a-5p FGF2 1.46749674755271 3.34605004270294e-07 -3.45935256477983 3.20406041037898e-17 mirMAP -0.184223429205561 0.0142842130111975 NA NA NA hsa-miR-32-5p FGF2 2.34056473219422 6.24134585974322e-20 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.528631961245202 2.37324737115731e-12 NA NA NA hsa-miR-330-3p FGF2 0.876747334239085 0.00073709016089703 -3.45935256477983 3.20406041037898e-17 mirMAP -0.408493425882602 1.96553818290449e-07 NA NA NA hsa-miR-335-3p FGF2 3.08791651139852 5.31309869723517e-12 -3.45935256477983 3.20406041037898e-17 mirMAP -0.283343671500426 1.16812423839489e-10 NA NA NA hsa-miR-335-5p FGF2 1.77247705492746 2.22457658872091e-06 -3.45935256477983 3.20406041037898e-17 miRNATAP -0.204481115239778 0.000164239409089154 NA NA NA hsa-miR-361-5p FGF2 0.971859117235239 5.30236555707088e-09 -3.45935256477983 3.20406041037898e-17 mirMAP -1.05676685455326 5.59900406122503e-19 NA NA NA hsa-miR-374a-3p FGF2 0.533309330504947 0.00192918429705142 -3.45935256477983 3.20406041037898e-17 mirMAP -0.25459376280057 0.0364309341812607 NA NA NA hsa-miR-424-5p FGF2 1.61930224569578 1.89642549274994e-10 -3.45935256477983 3.20406041037898e-17 MirTarget;miRNATAP -0.199023712638781 0.0127013546608619 NA NA NA hsa-miR-429 FGF2 4.48815175680773 2.44117492218206e-17 -3.45935256477983 3.20406041037898e-17 mirMAP -0.410445998774638 1.8378122494787e-32 NA NA NA hsa-miR-450b-5p FGF2 1.69244418548325 1.68064054148881e-10 -3.45935256477983 3.20406041037898e-17 mirMAP -0.300742012229277 7.83074250991869e-05 NA NA NA hsa-miR-452-5p FGF2 1.37180058737183 0.00171494843537772 -3.45935256477983 3.20406041037898e-17 mirMAP -0.212195200331281 5.19684741170909e-06 NA NA NA hsa-miR-503-5p FGF2 3.66513190181895 6.60300917645278e-21 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.407288478531313 2.50922381458507e-15 NA NA NA hsa-miR-589-3p FGF2 2.51971841868825 2.39125940264107e-11 -3.45935256477983 3.20406041037898e-17 mirMAP -0.381356804586547 1.66276905891645e-10 NA NA NA hsa-miR-590-3p FGF2 2.59289455139753 1.03200520972022e-21 -3.45935256477983 3.20406041037898e-17 miRanda;mirMAP -0.518258185319804 1.08846109843951e-12 NA NA NA hsa-miR-590-5p FGF2 3.18300989862077 2.06813568597893e-26 -3.45935256477983 3.20406041037898e-17 miRanda;mirMAP -0.632565141691195 1.29154238410301e-23 NA NA NA hsa-miR-664a-3p FGF2 0.634721925861133 0.00520070178640421 -3.45935256477983 3.20406041037898e-17 mirMAP -0.355728775133404 9.0166815375644e-05 NA NA NA hsa-miR-92a-3p FGF2 2.06460102658973 1.44784291084757e-19 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.899992154982756 2.08015519442665e-28 NA NA NA hsa-miR-93-3p FGF2 2.85383869771942 5.64481766902125e-23 -3.45935256477983 3.20406041037898e-17 mirMAP -0.750363342236745 4.93373884627099e-33 NA NA NA hsa-miR-944 FGF2 2.91186649218281 1.31574753528144e-06 -3.45935256477983 3.20406041037898e-17 MirTarget -0.33196588658737 1.10637179732889e-23 NA NA NA hsa-miR-100-5p FGFR3 -1.48442967087177 1.5610956769298e-05 1.15552976289114 0.0896174662454542 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.39236626068709 3.31966324164684e-05 23778527;25344675;26604796;26018508 Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress;MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3 poor survival;;; bladder cancer;pancreatic cancer;glioblastoma;sarcoma hsa-miR-142-3p FGFR3 2.75247908790621 1.45636065474764e-12 1.15552976289114 0.0896174662454542 miRanda -0.216798137380456 0.00854904538212289 NA NA NA hsa-miR-99a-5p FGFR3 -1.90541207788117 1.19082238183432e-05 1.15552976289114 0.0896174662454542 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.278809233789285 0.00018764039323491 23409016;24456664;23298836 Photofrin based photodynamic therapy and miR 99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo; Further photofrin based PDT followed by miR-99a transfection dramatically increased miR-99a expression and also increased apoptosis in glioblastoma cell cultures and drastically reduced tumor growth in athymic nude mice due to down regulation of fibroblast growth factor receptor 3 FGFR3 and PI3K/Akt signaling mechanisms leading to inhibition of cell proliferation and induction of molecular mechanisms of apoptosis;miR 99a promotes proliferation targeting FGFR3 in human epithelial ovarian cancer cells; Importantly fibroblast growth factor receptor 3 FGFR3 predicted to be one target gene of miR-99a using computational algorithms was higher in expression in EOC cells; Subsequently FGFR3 was proved to be direct target of miR-99a by dual luciferase assay; Furthermore overexpression of miR-99a dramatically suppressed expression level of FGFR3 at both mRNA and protein levels proving FGFR3 to be inversely correlated with miR-99a; Finally overexpression of miR-99a could significantly inhibit EOC cell proliferation in vitro by decreasing the expression of FGFR3 which also reduced the EOC cell growth after siRNA knockdown; Conclusively miR-99a expression was remarkably downregulated in serums tissues and cell and suppresses EOC cell proliferation by targeting FGFR3 suggesting miR-99a as a prospective prognosis marker and potential tumor suppressor for EOC therapeutics;The tumorigenic FGFR3 TACC3 gene fusion escapes miR 99a regulation in glioblastoma; The fusion caused by tandem duplication on 4p16.3 led to the loss of the 3'-UTR of FGFR3 blocking gene regulation of miR-99a and enhancing expression of the fusion gene ;worse prognosis; glioblastoma;ovarian cancer;glioblastoma hsa-miR-101-3p FZD6 0.522819989585461 0.00375627731618038 0.392854306882718 0.0923152139379722 miRNAWalker2_validate;MirTarget -0.149729036834899 0.0179745702090095 NA NA NA hsa-miR-139-5p FZD6 -1.52606598644743 1.20474151350665e-08 0.392854306882718 0.0923152139379722 miRanda -0.185158723711081 7.18808904187687e-06 NA NA NA hsa-miR-140-5p FZD6 0.844753502512594 3.73722278438606e-05 0.392854306882718 0.0923152139379722 MirTarget;miRanda -0.137728919670016 0.0125680010765223 NA NA NA hsa-miR-199a-5p FZD6 0.592984035153911 0.0674836634175293 0.392854306882718 0.0923152139379722 MirTarget;miRanda;miRNATAP -0.124790773147726 0.000323934870815636 25772759 FZD6 expression is negatively regulated by miR 199a 5p in human colorectal cancer; These results suggest that overexpression of FZD6 mediated by reduced expression of miR-199a-5p may play an important role in the development of CRC colorectal cancer hsa-miR-106b-3p HIF1A 1.74115042407425 7.96524575137272e-14 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate -0.115876573349366 0.01114041942823 NA NA NA hsa-miR-106b-5p HIF1A 2.46782146831112 1.36171495805632e-23 -0.0887083952652183 0.694448347585856 MirTarget -0.22506470406352 5.67731754915871e-08 NA NA NA hsa-miR-107 HIF1A 1.30977326593435 1.30372468603965e-11 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate;miRTarBase;miRanda -0.123422589068387 0.0264755744668062 NA NA NA hsa-miR-151a-3p HIF1A 1.24018761527407 1.08839919675408e-07 -0.0887083952652183 0.694448347585856 MirTarget -0.16533909856988 0.000338305910074446 NA NA NA hsa-miR-20a-5p HIF1A 3.15577933619191 4.19753346442454e-25 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate;miRTarBase;MirTarget -0.115406855575695 0.000600547799598935 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-28-5p HIF1A 0.230152919654905 0.0742909586754846 -0.0887083952652183 0.694448347585856 miRanda -0.410823482574077 2.0450455286232e-06 NA NA NA hsa-miR-330-3p HIF1A 0.876747334239085 0.00073709016089703 -0.0887083952652183 0.694448347585856 MirTarget;PITA -0.100136266436928 0.0170482873133228 NA NA NA hsa-miR-361-5p HIF1A 0.971859117235239 5.30236555707088e-09 -0.0887083952652183 0.694448347585856 miRanda -0.240248110278126 0.00022502129165918 NA NA NA hsa-miR-660-5p HIF1A 1.82692095272076 1.92040083607196e-13 -0.0887083952652183 0.694448347585856 MirTarget -0.138381785632354 0.00119715434144136 NA NA NA hsa-miR-93-5p HIF1A 3.03961860136032 1.11672209617395e-24 -0.0887083952652183 0.694448347585856 MirTarget -0.194707893705988 1.28811205175096e-08 NA NA NA hsa-miR-32-3p ITGA6 2.02436999565685 5.94091197945307e-09 -0.212335333681905 0.54809812089726 mirMAP -0.125053790799562 0.0233466106155737 NA NA NA hsa-miR-32-5p ITGA6 2.34056473219422 6.24134585974322e-20 -0.212335333681905 0.54809812089726 miRNAWalker2_validate -0.12876015171195 0.0444432225615113 NA NA NA hsa-miR-10b-3p ITGAV 0.77597971642517 0.00264877454133753 -0.0552493406333632 0.795714969238101 MirTarget -0.158358641589343 6.69225270139789e-05 NA NA NA hsa-miR-141-3p ITGAV 5.02396127982626 2.19224509139725e-24 -0.0552493406333632 0.795714969238101 MirTarget -0.125634945314397 7.01655633438231e-11 NA NA NA hsa-miR-16-2-3p ITGAV 2.31623086727196 4.29838149388188e-20 -0.0552493406333632 0.795714969238101 mirMAP -0.199617274846503 2.43792627503413e-07 NA NA NA hsa-miR-186-5p ITGAV 1.47445398888668 3.0781726595413e-15 -0.0552493406333632 0.795714969238101 mirMAP -0.359656849104508 8.23776291207508e-12 NA NA NA hsa-miR-192-5p ITGAV 2.69002528723195 1.22990188194432e-16 -0.0552493406333632 0.795714969238101 miRNAWalker2_validate;MirTarget -0.190974902652764 1.81642812826116e-10 NA NA NA hsa-miR-200a-3p ITGAV 4.59434485520731 6.38952518573476e-18 -0.0552493406333632 0.795714969238101 MirTarget -0.131709203257402 2.633117959538e-13 NA NA NA hsa-miR-25-3p ITGAV 1.36472605225697 4.83790725935681e-11 -0.0552493406333632 0.795714969238101 MirTarget;miRNATAP -0.393852941867199 6.6348888648572e-17 NA NA NA hsa-miR-30e-3p ITGAV -0.215663037684509 0.235375122783546 -0.0552493406333632 0.795714969238101 mirMAP -0.339795441635055 1.84221609877849e-09 NA NA NA hsa-miR-32-5p ITGAV 2.34056473219422 6.24134585974322e-20 -0.0552493406333632 0.795714969238101 miRNAWalker2_validate;MirTarget;miRNATAP -0.21813171757581 9.13747743396107e-09 NA NA NA hsa-miR-328-3p ITGAV 0.596804159297544 0.013858523511843 -0.0552493406333632 0.795714969238101 MirTarget -0.184239805543996 1.34681288230083e-05 NA NA NA hsa-miR-331-5p ITGAV 2.17414714166315 1.54547681391888e-18 -0.0552493406333632 0.795714969238101 PITA -0.200744994858149 8.42791176390003e-07 NA NA NA hsa-miR-33a-3p ITGAV 1.72765312072219 1.51784443453521e-07 -0.0552493406333632 0.795714969238101 MirTarget -0.20605161346585 6.47893191633007e-10 NA NA NA hsa-miR-361-5p ITGAV 0.971859117235239 5.30236555707088e-09 -0.0552493406333632 0.795714969238101 MirTarget;miRanda -0.428107639008486 1.15708286730063e-12 NA NA NA hsa-miR-363-3p ITGAV 1.50575300026701 0.00020976164678918 -0.0552493406333632 0.795714969238101 MirTarget -0.108742654034656 1.39301773890387e-05 NA NA NA hsa-miR-374a-5p ITGAV 0.484615721953736 0.0042981729815149 -0.0552493406333632 0.795714969238101 mirMAP -0.234655511836942 0.000126489523100171 NA NA NA hsa-miR-374b-5p ITGAV 0.0654362503857184 0.722673188879465 -0.0552493406333632 0.795714969238101 mirMAP -0.168523506852159 0.00292302259316201 NA NA NA hsa-miR-429 ITGAV 4.48815175680773 2.44117492218206e-17 -0.0552493406333632 0.795714969238101 miRanda -0.127193818759143 2.65456116358475e-12 NA NA NA hsa-miR-576-5p ITGAV 2.20467023993664 3.4053475193793e-19 -0.0552493406333632 0.795714969238101 PITA;mirMAP -0.196724599850144 7.64027152189049e-07 NA NA NA hsa-miR-582-3p ITGAV 0.00876844181512659 0.977126166214707 -0.0552493406333632 0.795714969238101 MirTarget -0.126654225661071 0.00016778168578043 NA NA NA hsa-miR-589-3p ITGAV 2.51971841868825 2.39125940264107e-11 -0.0552493406333632 0.795714969238101 MirTarget -0.126299636648124 2.84553241173989e-05 NA NA NA hsa-miR-590-3p ITGAV 2.59289455139753 1.03200520972022e-21 -0.0552493406333632 0.795714969238101 MirTarget;PITA;miRanda -0.192092523174197 1.80193428945462e-07 NA NA NA hsa-miR-7-1-3p ITGAV 1.84950311431067 1.25300363397654e-13 -0.0552493406333632 0.795714969238101 mirMAP -0.236895615730496 2.11030326941029e-09 NA NA NA hsa-miR-92a-3p ITGAV 2.06460102658973 1.44784291084757e-19 -0.0552493406333632 0.795714969238101 MirTarget;miRNATAP -0.311573118807097 1.56062452922841e-13 NA NA NA hsa-let-7g-3p JAK1 3.26398061402445 3.96263126107645e-25 -0.647144039203939 3.25551149817466e-06 MirTarget -0.160173599472765 1.98343469212566e-15 NA NA NA hsa-miR-106a-5p JAK1 2.48882002962836 1.99757727374521e-12 -0.647144039203939 3.25551149817466e-06 MirTarget -0.133261991596329 2.08270266659009e-13 NA NA NA hsa-miR-106b-5p JAK1 2.46782146831112 1.36171495805632e-23 -0.647144039203939 3.25551149817466e-06 miRNAWalker2_validate;MirTarget -0.270448677438555 1.81937362986755e-28 NA NA NA hsa-miR-128-3p JAK1 1.63756041666078 6.79626586407187e-14 -0.647144039203939 3.25551149817466e-06 miRNAWalker2_validate -0.23450814388999 1.21522000897489e-15 NA NA NA hsa-miR-15b-5p JAK1 1.57112623124278 9.14247846750597e-13 -0.647144039203939 3.25551149817466e-06 miRNAWalker2_validate -0.202388635992569 6.7540767380457e-12 NA NA NA hsa-miR-17-5p JAK1 3.2710598467455 9.93128340539455e-27 -0.647144039203939 3.25551149817466e-06 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.190095912387356 9.24241683512841e-22 NA NA NA hsa-miR-20a-5p JAK1 3.15577933619191 4.19753346442454e-25 -0.647144039203939 3.25551149817466e-06 MirTarget -0.19658594535312 5.11615429760049e-23 NA NA NA hsa-miR-28-5p JAK1 0.230152919654905 0.0742909586754846 -0.647144039203939 3.25551149817466e-06 miRanda;miRNATAP -0.170979664648501 0.00160634337684464 NA NA NA hsa-miR-30b-5p JAK1 0.800822374912712 0.000133601914525413 -0.647144039203939 3.25551149817466e-06 MirTarget -0.161576536892966 4.64284555422181e-07 NA NA NA hsa-miR-30c-5p JAK1 0.778774633108 0.000285599212429136 -0.647144039203939 3.25551149817466e-06 MirTarget -0.201102336728054 8.89538183624433e-11 NA NA NA hsa-miR-30d-5p JAK1 0.675423997639582 0.00270618816039773 -0.647144039203939 3.25551149817466e-06 MirTarget -0.154865436420283 2.14924883319783e-07 NA NA NA hsa-miR-30e-5p JAK1 1.23904909539663 1.35561917122157e-09 -0.647144039203939 3.25551149817466e-06 MirTarget -0.230082866037824 6.16026755354551e-13 NA NA NA hsa-miR-421 JAK1 1.17791565395543 6.78526676976629e-06 -0.647144039203939 3.25551149817466e-06 miRanda -0.147691711558544 6.10849726240234e-09 NA NA NA hsa-miR-93-5p JAK1 3.03961860136032 1.11672209617395e-24 -0.647144039203939 3.25551149817466e-06 MirTarget;miRNATAP -0.231847990523344 8.3596082797108e-31 NA NA NA hsa-miR-590-3p LAMA2 2.59289455139753 1.03200520972022e-21 -2.83761923067566 3.05345389505506e-15 miRanda -0.567223566221854 9.61700716671867e-20 NA NA NA hsa-miR-218-5p LAMB3 -0.573801507392184 0.0551983860126703 1.04442552777857 0.0544713405047334 miRNAWalker2_validate;miRTarBase -0.319152266391447 0.000275496727879032 25337271;20163849;23320911;23159910;17998940 The aim of this study was to investigate whether polymorphisms in miR-218 LAMB3 pathway were associated with the risk and prognosis of esophageal squamous cell carcinoma ESCC;Polymorphisms involved in the miR 218 LAMB3 pathway and susceptibility of cervical cancer a case control study in Chinese women; MicroRNA-218 miR-218 can target laminin-5 beta3 LAMB3 but suppressed by HPV-16 E6 protein;However this association was not observed for the miR-218 binding site SNP rs2566 on LAMB3;Furthermore we focused on LAMB3 which has a miR-218 target site and gene expression studies and luciferase reporter assays showed that LAMB3 was directly regulated by miR-218;We also demonstrate that the epithelial cell-specific marker LAMB3 is a target of miR-218; We also show that LAMB3 expression is increased in the presence of the HPV-16 E6 oncogene and this effect is mediated through miR-218 worse prognosis;;;; esophageal cancer;cervical and endocervical cancer;cervical and endocervical cancer;head and neck cancer;cervical and endocervical cancer hsa-miR-101-3p MAP2K1 0.522819989585461 0.00375627731618038 0.329146605656592 0.0110879553061078 miRNAWalker2_validate -0.179174585612232 2.32589570104786e-07 NA NA NA hsa-miR-30c-5p MAP2K1 0.778774633108 0.000285599212429136 0.329146605656592 0.0110879553061078 miRNAWalker2_validate -0.1435696131991 6.86626187272449e-07 NA NA NA hsa-miR-132-3p MECOM 0.156276992635384 0.408190812100704 -0.109766204398782 0.777087697908525 miRNATAP -0.551498616022579 2.64142523081905e-08 NA NA NA hsa-miR-142-5p MECOM 1.17581605694506 0.0018174701991234 -0.109766204398782 0.777087697908525 mirMAP -0.31278909669877 1.11068062239882e-10 NA NA NA hsa-miR-19a-3p MECOM 3.42309334186656 3.02671914353412e-28 -0.109766204398782 0.777087697908525 miRNATAP -0.117894864409727 0.0370200160466719 NA NA NA hsa-miR-212-3p MECOM 0.357878936470387 0.232446214501331 -0.109766204398782 0.777087697908525 miRNATAP -0.383981079864799 5.6860663822736e-10 NA NA NA hsa-miR-338-3p MECOM 0.453166438193782 0.144583389707558 -0.109766204398782 0.777087697908525 miRanda;miRNATAP -0.313178724017969 1.57594597494315e-07 NA NA NA hsa-miR-338-5p MECOM -0.577691606146419 0.0472212680542825 -0.109766204398782 0.777087697908525 miRNATAP -0.402401413958955 2.85690530112099e-10 NA NA NA hsa-miR-362-3p MECOM 2.0756816987665 3.89026064579331e-12 -0.109766204398782 0.777087697908525 miRanda -0.157578301938422 0.0127220218870796 NA NA NA hsa-miR-455-5p MECOM 2.2582442061694 1.43472128037398e-13 -0.109766204398782 0.777087697908525 miRanda -0.161778635177407 0.00665472877781778 NA NA NA hsa-miR-493-5p MECOM 0.847772103665986 0.00528678068747754 -0.109766204398782 0.777087697908525 miRNATAP -0.198214098341916 0.0013139872245572 NA NA NA hsa-miR-450b-5p NFKB1 1.69244418548325 1.68064054148881e-10 -0.64818153460532 4.948433163113e-05 MirTarget;PITA -0.124463449584444 1.35101416784659e-05 NA NA NA hsa-miR-92a-3p NFKB1 2.06460102658973 1.44784291084757e-19 -0.64818153460532 4.948433163113e-05 miRNAWalker2_validate -0.146602812476967 6.42472618908431e-06 NA NA NA hsa-miR-29c-3p NRAS -0.00968972577705429 0.97099586346872 0.638705716882092 3.80929355945655e-05 miRNATAP -0.151007715222895 7.79757166468808e-08 NA NA NA hsa-miR-664a-3p NRAS 0.634721925861133 0.00520070178640421 0.638705716882092 3.80929355945655e-05 MirTarget -0.156789929856636 2.10592676639858e-06 NA NA NA hsa-miR-320a PIAS1 0.438165828017084 0.0390159073347133 -0.418729293611933 0.00292984750388141 miRanda -0.121903226298068 0.000153288911124725 NA NA NA hsa-miR-342-3p PIAS1 1.49115144672245 1.43879249744621e-07 -0.418729293611933 0.00292984750388141 miRanda -0.133923012065101 1.03123868615213e-08 NA NA NA hsa-miR-590-3p PIAS1 2.59289455139753 1.03200520972022e-21 -0.418729293611933 0.00292984750388141 miRanda -0.106634579542964 1.30275464980239e-05 NA NA NA hsa-miR-148b-3p PIK3CG 1.97815018171325 6.07715327281595e-26 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.598035215538084 7.05982657783629e-10 NA NA NA hsa-miR-26b-5p PIK3CG 0.885393662798425 3.2116297961629e-06 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.252635166842034 0.0140326902426817 NA NA NA hsa-miR-335-3p PIK3CG 3.08791651139852 5.31309869723517e-12 -1.04493260087656 0.00941484120426313 mirMAP -0.182751911295676 1.44284270796844e-05 NA NA NA hsa-miR-3607-3p PIK3CG 2.68532138541128 5.66716351955047e-14 -1.04493260087656 0.00941484120426313 mirMAP -0.166734433414221 0.00216182223501734 NA NA NA hsa-miR-421 PIK3CG 1.17791565395543 6.78526676976629e-06 -1.04493260087656 0.00941484120426313 miRanda -0.208294811185602 0.00505346682917229 NA NA NA hsa-miR-590-3p PIK3CG 2.59289455139753 1.03200520972022e-21 -1.04493260087656 0.00941484120426313 miRanda -0.160421801003692 0.0232620908281926 NA NA NA hsa-miR-101-5p PIK3R1 0.782067874775122 0.00443725251526842 -1.16357283690918 1.63774086027679e-06 MirTarget -0.115568250605295 0.00948870207662742 NA NA NA hsa-miR-103a-3p PIK3R1 1.44083190496858 1.53799939616416e-13 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.175702483843164 0.00322284399016944 NA NA NA hsa-miR-106b-5p PIK3R1 2.46782146831112 1.36171495805632e-23 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.24930934707311 3.35624085651532e-08 NA NA NA hsa-miR-107 PIK3R1 1.30977326593435 1.30372468603965e-11 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.201353514049413 0.000854368494298006 NA NA NA hsa-miR-127-5p PIK3R1 1.19850695520181 4.10976607177645e-05 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.164276045731973 4.35688271416755e-05 24004856 Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR 127 in human bladder cancer; These findings provide new insights into the role of miRNAs in the pathway of cancer and give us a hypothesis that miR-127 might play a similar role in regulation and control of PIK3R1 bladder cancer hsa-miR-128-3p PIK3R1 1.63756041666078 6.79626586407187e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.134770050316621 0.0111594593028352 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 2.54959518791507 5.26618591274892e-18 -1.16357283690918 1.63774086027679e-06 MirTarget -0.146009716288673 0.000153002833756534 NA NA NA hsa-miR-132-3p PIK3R1 0.156276992635384 0.408190812100704 -1.16357283690918 1.63774086027679e-06 MirTarget -0.197496588157407 0.00191277589406782 NA NA NA hsa-miR-15a-5p PIK3R1 2.34669284378787 1.69544424500258e-23 -1.16357283690918 1.63774086027679e-06 MirTarget -0.142181030175195 0.00308171212654804 NA NA NA hsa-miR-15b-5p PIK3R1 1.57112623124278 9.14247846750597e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203388250610072 0.000112366544945594 NA NA NA hsa-miR-16-2-3p PIK3R1 2.31623086727196 4.29838149388188e-20 -1.16357283690918 1.63774086027679e-06 MirTarget -0.207543782293348 3.49270114018875e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.75824877145857 1.68592440033108e-16 -1.16357283690918 1.63774086027679e-06 MirTarget -0.20266090985161 0.000166722510489398 NA NA NA hsa-miR-17-5p PIK3R1 3.2710598467455 9.93128340539455e-27 -1.16357283690918 1.63774086027679e-06 MirTarget;TargetScan;miRNATAP -0.194269031204595 7.03363082546611e-08 NA NA NA hsa-miR-185-5p PIK3R1 2.34016206907488 1.17481626642022e-26 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.305558512858305 1.29388513669652e-09 NA NA NA hsa-miR-186-5p PIK3R1 1.47445398888668 3.0781726595413e-15 -1.16357283690918 1.63774086027679e-06 mirMAP -0.274872917366815 8.27585129634137e-06 NA NA NA hsa-miR-188-5p PIK3R1 2.52825126596644 6.78099435999778e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.185661747772095 2.50402606338374e-07 NA NA NA hsa-miR-199a-3p PIK3R1 0.640600337515787 0.0380326905134914 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.156998919927599 4.11373421997523e-05 NA NA NA hsa-miR-199b-3p PIK3R1 0.643923492750702 0.0371742251925406 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.157124307871095 4.00275047495595e-05 NA NA NA hsa-miR-20a-5p PIK3R1 3.15577933619191 4.19753346442454e-25 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.184775072209508 3.70396511881761e-07 NA NA NA hsa-miR-21-5p PIK3R1 2.73773305747971 1.38864982139576e-43 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.344443286817705 1.08270725892964e-10 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.357878936470387 0.232446214501331 -1.16357283690918 1.63774086027679e-06 MirTarget -0.126995222417611 0.00147059810557586 NA NA NA hsa-miR-22-5p PIK3R1 1.88011544159252 1.63978222572222e-16 -1.16357283690918 1.63774086027679e-06 mirMAP -0.292552038138818 3.89552165607854e-09 NA NA NA hsa-miR-221-3p PIK3R1 0.451556679024397 0.0909808299917811 -1.16357283690918 1.63774086027679e-06 MirTarget -0.108240747635063 0.015387314456947 NA NA NA hsa-miR-222-3p PIK3R1 0.851783756239071 0.00266783568486918 -1.16357283690918 1.63774086027679e-06 MirTarget -0.122260306324505 0.00346350093932025 NA NA NA hsa-miR-29a-3p PIK3R1 -0.35074463683376 0.161238718982428 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.197768036084372 3.04095884680599e-05 NA NA NA hsa-miR-29b-3p PIK3R1 1.65828197923813 1.02676780888141e-09 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.226570180742736 9.59427672061032e-08 NA NA NA hsa-miR-3065-5p PIK3R1 2.74629919868982 1.86846589298284e-08 -1.16357283690918 1.63774086027679e-06 MirTarget;mirMAP;miRNATAP -0.121456370441073 3.04699134862982e-05 NA NA NA hsa-miR-369-3p PIK3R1 0.946781510019564 0.00134850306966842 -1.16357283690918 1.63774086027679e-06 PITA -0.165045838001649 3.68847028364345e-05 NA NA NA hsa-miR-409-3p PIK3R1 0.877551657794358 0.00171210686733898 -1.16357283690918 1.63774086027679e-06 mirMAP -0.105859697586648 0.0126015776971144 NA NA NA hsa-miR-424-5p PIK3R1 1.61930224569578 1.89642549274994e-10 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203727044936863 7.79524954848401e-06 NA NA NA hsa-miR-450b-5p PIK3R1 1.69244418548325 1.68064054148881e-10 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.119371689321084 0.0066882062526509 NA NA NA hsa-miR-455-3p PIK3R1 3.06093594997644 3.54590649799868e-16 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.151223028806072 5.34851043578223e-07 NA NA NA hsa-miR-485-3p PIK3R1 0.442820096243914 0.166634696770945 -1.16357283690918 1.63774086027679e-06 mirMAP -0.104228852223792 0.00542492277409986 NA NA NA hsa-miR-493-5p PIK3R1 0.847772103665986 0.00528678068747754 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.141629319654 0.000286613564823519 NA NA NA hsa-miR-532-3p PIK3R1 1.96631878320218 4.53421954361695e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.183574493282594 1.45132602336302e-05 NA NA NA hsa-miR-584-5p PIK3R1 2.7326672683732 9.92677936962233e-12 -1.16357283690918 1.63774086027679e-06 mirMAP -0.136506526285572 1.76178566940588e-06 NA NA NA hsa-miR-589-3p PIK3R1 2.51971841868825 2.39125940264107e-11 -1.16357283690918 1.63774086027679e-06 mirMAP -0.146863008859422 2.43953052082368e-05 NA NA NA hsa-miR-590-3p PIK3R1 2.59289455139753 1.03200520972022e-21 -1.16357283690918 1.63774086027679e-06 miRanda;mirMAP -0.251414695908109 2.6774008322444e-09 NA NA NA hsa-miR-590-5p PIK3R1 3.18300989862077 2.06813568597893e-26 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.233958943001206 5.13569363038349e-10 NA NA NA hsa-miR-629-3p PIK3R1 2.36570947321815 1.33458201201618e-11 -1.16357283690918 1.63774086027679e-06 MirTarget -0.157530213698435 2.37486100403133e-05 NA NA NA hsa-miR-93-5p PIK3R1 3.03961860136032 1.11672209617395e-24 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.155676924698248 3.5347453293642e-05 NA NA NA hsa-miR-96-5p PIK3R1 4.89433085814374 1.92000659886961e-31 -1.16357283690918 1.63774086027679e-06 TargetScan;miRNATAP -0.102966561567807 0.000122371084822612 NA NA NA hsa-miR-129-5p PRKCB -0.524170159980738 0.222582956006346 -3.26032077132529 1.38524824909011e-12 miRanda;mirMAP -0.174875281711081 0.00126377112961492 NA NA NA hsa-miR-141-5p PRKCB 3.81419396518882 3.21977359736126e-18 -3.26032077132529 1.38524824909011e-12 mirMAP -0.448157631252767 6.03056466923945e-21 NA NA NA hsa-miR-16-2-3p PRKCB 2.31623086727196 4.29838149388188e-20 -3.26032077132529 1.38524824909011e-12 mirMAP -0.508156111029493 2.858696818642e-09 NA NA NA hsa-miR-186-5p PRKCB 1.47445398888668 3.0781726595413e-15 -3.26032077132529 1.38524824909011e-12 mirMAP -0.79180135498475 1.36020814670637e-11 NA NA NA hsa-miR-194-5p PRKCB 1.8992998339217 3.76507853301977e-10 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.485081827287577 2.16525492854143e-11 NA NA NA hsa-miR-200b-3p PRKCB 3.78235093249346 3.18343003239465e-14 -3.26032077132529 1.38524824909011e-12 MirTarget -0.450279840251611 3.58923445938153e-27 NA NA NA hsa-miR-200c-3p PRKCB 3.50132673580082 2.42716349086937e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.48715771688849 5.01263551249731e-25 NA NA NA hsa-miR-23a-3p PRKCB 1.00493340843378 2.55313889288924e-08 -3.26032077132529 1.38524824909011e-12 mirMAP -0.422834753714352 0.000810959402297788 NA NA NA hsa-miR-24-3p PRKCB 0.99989036772428 1.35595013650376e-07 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.496540154032259 3.34685620532722e-05 NA NA NA hsa-miR-26b-5p PRKCB 0.885393662798425 3.2116297961629e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.316938073060502 0.0085744560045255 NA NA NA hsa-miR-27a-3p PRKCB 1.66542180327138 4.93775737894805e-13 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.232202797991253 0.016976866126181 NA NA NA hsa-miR-29b-2-5p PRKCB 0.910668640983475 0.00666655585493488 -3.26032077132529 1.38524824909011e-12 mirMAP -0.34510237827648 3.08410596869229e-07 NA NA NA hsa-miR-30b-5p PRKCB 0.800822374912712 0.000133601914525413 -3.26032077132529 1.38524824909011e-12 mirMAP -0.425134820547528 9.53655468608799e-05 NA NA NA hsa-miR-30c-5p PRKCB 0.778774633108 0.000285599212429136 -3.26032077132529 1.38524824909011e-12 mirMAP -0.468954366973799 1.00031056614682e-05 NA NA NA hsa-miR-30d-3p PRKCB 0.977747550180601 4.3048212205381e-05 -3.26032077132529 1.38524824909011e-12 mirMAP -0.529262539307465 2.03079793114812e-08 NA NA NA hsa-miR-30d-5p PRKCB 0.675423997639582 0.00270618816039773 -3.26032077132529 1.38524824909011e-12 mirMAP -0.603674275615055 1.78624617709124e-09 NA NA NA hsa-miR-330-5p PRKCB 1.15100069700871 4.85551805046014e-07 -3.26032077132529 1.38524824909011e-12 miRanda -0.265696306996962 0.00757029049385514 NA NA NA hsa-miR-335-3p PRKCB 3.08791651139852 5.31309869723517e-12 -3.26032077132529 1.38524824909011e-12 mirMAP -0.330098295724148 1.15037296640229e-11 NA NA NA hsa-miR-335-5p PRKCB 1.77247705492746 2.22457658872091e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.231797522536577 0.000116559468268159 NA NA NA hsa-miR-3607-3p PRKCB 2.68532138541128 5.66716351955047e-14 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.309871089079837 9.51108883796167e-07 NA NA NA hsa-miR-361-5p PRKCB 0.971859117235239 5.30236555707088e-09 -3.26032077132529 1.38524824909011e-12 MirTarget;miRanda;miRNATAP -1.08630383105364 2.58179254217249e-16 NA NA NA hsa-miR-429 PRKCB 4.48815175680773 2.44117492218206e-17 -3.26032077132529 1.38524824909011e-12 MirTarget;miRanda;miRNATAP -0.42521096062837 6.46582126393278e-28 NA NA NA hsa-miR-450b-5p PRKCB 1.69244418548325 1.68064054148881e-10 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.300053601902219 0.00039020696289519 NA NA NA hsa-miR-452-3p PRKCB 2.42521958420768 4.08754552781156e-07 -3.26032077132529 1.38524824909011e-12 mirMAP -0.174939955360914 0.000207028768427815 NA NA NA hsa-miR-484 PRKCB 1.81844463411787 1.82951571230938e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.703163397284051 1.07982697132474e-13 NA NA NA hsa-miR-491-5p PRKCB 0.615770352820862 0.0418295628761654 -3.26032077132529 1.38524824909011e-12 miRanda -0.381404660757775 2.20068611106109e-06 NA NA NA hsa-miR-539-5p PRKCB 0.95216780650456 0.00284373332122135 -3.26032077132529 1.38524824909011e-12 mirMAP -0.145994158707678 0.0431444523519716 NA NA NA hsa-miR-589-3p PRKCB 2.51971841868825 2.39125940264107e-11 -3.26032077132529 1.38524824909011e-12 mirMAP -0.452218517865859 7.06052991667871e-12 NA NA NA hsa-miR-589-5p PRKCB 1.71990116752371 8.310889042056e-14 -3.26032077132529 1.38524824909011e-12 mirMAP -0.544486942502154 1.22125132593852e-08 NA NA NA hsa-miR-590-3p PRKCB 2.59289455139753 1.03200520972022e-21 -3.26032077132529 1.38524824909011e-12 mirMAP -0.388404821887359 2.22817064825303e-06 NA NA NA hsa-miR-590-5p PRKCB 3.18300989862077 2.06813568597893e-26 -3.26032077132529 1.38524824909011e-12 miRanda -0.553979313426607 1.10231423603006e-14 NA NA NA hsa-miR-7-1-3p PRKCB 1.84950311431067 1.25300363397654e-13 -3.26032077132529 1.38524824909011e-12 mirMAP -0.468511892026853 1.14425525890782e-07 NA NA NA hsa-miR-7-5p PRKCB 2.28980165299999 1.5131097560452e-07 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.171892302839442 0.00201428643670522 NA NA NA hsa-miR-944 PRKCB 2.91186649218281 1.31574753528144e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.173419280691746 6.46731956750453e-06 NA NA NA hsa-miR-135b-5p RALBP1 3.62510365056501 1.09148980810091e-10 0.406788131900375 0.126272070955269 MirTarget -0.145897738406072 3.52096577209254e-10 NA NA NA hsa-miR-217 RALBP1 0.608024397387488 0.199352491710517 0.406788131900375 0.126272070955269 PITA;miRanda -0.113030093250863 4.64500952576653e-05 NA NA NA hsa-miR-29a-5p RALBP1 1.46749674755271 3.34605004270294e-07 0.406788131900375 0.126272070955269 MirTarget;miRNATAP -0.152379489454174 0.00110811101629667 NA NA NA hsa-miR-107 RASSF5 1.30977326593435 1.30372468603965e-11 -0.459521846409834 0.057079929584638 PITA;miRanda;miRNATAP -0.125081238080756 0.035952796694623 NA NA NA hsa-miR-193b-3p RASSF5 2.25711804611899 4.1940744806631e-14 -0.459521846409834 0.057079929584638 miRNAWalker2_validate -0.107559281956556 0.00459789104354504 NA NA NA hsa-miR-339-5p RASSF5 2.68710938429893 3.03134080808154e-16 -0.459521846409834 0.057079929584638 miRanda -0.107050841152186 0.00175826341436271 NA NA NA hsa-miR-421 RASSF5 1.17791565395543 6.78526676976629e-06 -0.459521846409834 0.057079929584638 miRanda -0.240601388925521 4.19227001924012e-08 NA NA NA hsa-miR-450b-5p RASSF5 1.69244418548325 1.68064054148881e-10 -0.459521846409834 0.057079929584638 PITA -0.204968708939115 1.77651408873061e-06 NA NA NA hsa-miR-532-5p RASSF5 1.55697650978597 1.57884735535196e-11 -0.459521846409834 0.057079929584638 PITA;miRNATAP -0.104221854293184 0.0361521858515376 NA NA NA hsa-miR-542-3p RASSF5 1.18832665895751 1.98700670691565e-07 -0.459521846409834 0.057079929584638 miRanda -0.200729563421751 7.04676072523812e-05 NA NA NA hsa-let-7a-3p ROCK1 1.42015538786275 7.03375209382654e-13 -1.02661670614902 1.94754524728051e-09 MirTarget -0.16003331936042 0.000120540876738803 NA NA NA hsa-let-7g-3p ROCK1 3.26398061402445 3.96263126107645e-25 -1.02661670614902 1.94754524728051e-09 MirTarget -0.15581302459487 8.95130786544619e-10 NA NA NA hsa-miR-107 ROCK1 1.30977326593435 1.30372468603965e-11 -1.02661670614902 1.94754524728051e-09 miRanda -0.119087364388625 0.00550312830212256 NA NA NA hsa-miR-126-5p ROCK1 0.895338176458417 2.33372756450713e-05 -1.02661670614902 1.94754524728051e-09 mirMAP -0.172464120027516 1.27104399703317e-05 27108693 MicroRNA 126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma metastasis kidney renal cell cancer hsa-miR-148b-3p ROCK1 1.97815018171325 6.07715327281595e-26 -1.02661670614902 1.94754524728051e-09 miRNAWalker2_validate -0.279081182346667 2.14015194986577e-11 NA NA NA hsa-miR-16-1-3p ROCK1 2.56983217111073 3.02262181237943e-20 -1.02661670614902 1.94754524728051e-09 MirTarget -0.207917435482076 6.59320429139509e-13 NA NA NA hsa-miR-182-5p ROCK1 3.53923166221814 5.07781258121574e-21 -1.02661670614902 1.94754524728051e-09 MirTarget -0.129367164013929 6.18056517206253e-10 NA NA NA hsa-miR-190a-5p ROCK1 0.762748400660219 0.0035950590410453 -1.02661670614902 1.94754524728051e-09 MirTarget -0.112852694205429 0.000456951035558202 NA NA NA hsa-miR-196b-5p ROCK1 1.71646270856386 4.37735885910369e-09 -1.02661670614902 1.94754524728051e-09 MirTarget -0.105631135385179 0.000182173962330639 NA NA NA hsa-miR-199b-5p ROCK1 0.218704279044827 0.519493319158441 -1.02661670614902 1.94754524728051e-09 miRanda -0.105786266749066 1.83517740907298e-05 NA NA NA hsa-miR-320a ROCK1 0.438165828017084 0.0390159073347133 -1.02661670614902 1.94754524728051e-09 miRanda -0.23831134413994 1.32756646387868e-09 NA NA NA hsa-miR-320b ROCK1 1.55692969039548 1.41071034251915e-08 -1.02661670614902 1.94754524728051e-09 miRanda -0.159130778995994 1.01124713873982e-07 NA NA NA hsa-miR-324-5p ROCK1 2.95683728155095 1.32960514360912e-20 -1.02661670614902 1.94754524728051e-09 MirTarget;PITA;miRanda -0.118431313766168 2.2910613914641e-06 NA NA NA hsa-miR-582-5p ROCK1 0.609226359812689 0.032988717891497 -1.02661670614902 1.94754524728051e-09 PITA -0.11645225372736 7.38340442690333e-05 NA NA NA hsa-miR-664a-3p ROCK1 0.634721925861133 0.00520070178640421 -1.02661670614902 1.94754524728051e-09 mirMAP -0.244809843386458 1.76957821323578e-11 NA NA NA hsa-let-7a-3p ROCK2 1.42015538786275 7.03375209382654e-13 -1.27631616742797 8.42580604068128e-07 mirMAP -0.210808918216694 0.000797703640371582 NA NA NA hsa-miR-126-5p ROCK2 0.895338176458417 2.33372756450713e-05 -1.27631616742797 8.42580604068128e-07 mirMAP -0.189029821054627 0.00159176807510824 NA NA NA hsa-miR-127-5p ROCK2 1.19850695520181 4.10976607177645e-05 -1.27631616742797 8.42580604068128e-07 PITA -0.147350589855343 0.000623699318629899 NA NA NA hsa-miR-142-3p ROCK2 2.75247908790621 1.45636065474764e-12 -1.27631616742797 8.42580604068128e-07 PITA;miRanda;miRNATAP -0.106911050458868 0.000733555550863697 NA NA NA hsa-miR-17-5p ROCK2 3.2710598467455 9.93128340539455e-27 -1.27631616742797 8.42580604068128e-07 TargetScan -0.215326836171022 2.16038147723404e-08 NA NA NA hsa-miR-3607-3p ROCK2 2.68532138541128 5.66716351955047e-14 -1.27631616742797 8.42580604068128e-07 mirMAP -0.182162248755882 1.90545088147527e-07 NA NA NA hsa-miR-369-3p ROCK2 0.946781510019564 0.00134850306966842 -1.27631616742797 8.42580604068128e-07 PITA -0.129098178306128 0.00264599376211178 NA NA NA hsa-miR-500a-5p ROCK2 1.72110365584658 3.0807246212659e-10 -1.27631616742797 8.42580604068128e-07 mirMAP -0.154970725822778 0.000663866430657911 NA NA NA hsa-miR-539-5p ROCK2 0.95216780650456 0.00284373332122135 -1.27631616742797 8.42580604068128e-07 mirMAP -0.115978170349612 0.00365972634311164 NA NA NA hsa-miR-582-5p ROCK2 0.609226359812689 0.032988717891497 -1.27631616742797 8.42580604068128e-07 mirMAP -0.134198928299352 0.00253763920219959 NA NA NA hsa-miR-589-3p ROCK2 2.51971841868825 2.39125940264107e-11 -1.27631616742797 8.42580604068128e-07 mirMAP -0.122788727749752 0.0010074207494257 NA NA NA hsa-miR-590-3p ROCK2 2.59289455139753 1.03200520972022e-21 -1.27631616742797 8.42580604068128e-07 miRanda;mirMAP -0.185591580714152 4.79951683893355e-05 NA NA NA hsa-let-7g-5p SMC1A 1.20061455355116 1.50237505511483e-12 0.043831182387617 0.773298330936153 MirTarget -0.134829863013372 0.00155102065006135 NA NA NA hsa-miR-101-3p SMC1A 0.522819989585461 0.00375627731618038 0.043831182387617 0.773298330936153 mirMAP -0.236768801940013 4.64533901439356e-09 NA NA NA hsa-miR-181c-5p SMC1A 1.58587920618301 1.57506918816933e-10 0.043831182387617 0.773298330936153 mirMAP -0.111613137924956 0.000114342301365384 NA NA NA hsa-miR-218-5p SMC1A -0.573801507392184 0.0551983860126703 0.043831182387617 0.773298330936153 mirMAP -0.105234255044029 1.56648133305133e-05 NA NA NA hsa-miR-23b-3p SMC1A -0.251132426825047 0.150200321210792 0.043831182387617 0.773298330936153 mirMAP -0.133582876541337 0.00171021635432851 NA NA NA hsa-miR-320a SMC1A 0.438165828017084 0.0390159073347133 0.043831182387617 0.773298330936153 miRNAWalker2_validate -0.123748010459244 0.000360165063457412 NA NA NA hsa-miR-664a-3p SMC1A 0.634721925861133 0.00520070178640421 0.043831182387617 0.773298330936153 mirMAP -0.212742904131529 1.89458201251213e-11 NA NA NA hsa-miR-28-5p SMC3 0.230152919654905 0.0742909586754846 0.188489087089271 0.252993138933612 miRanda -0.152850866516808 0.0164864207131967 NA NA NA hsa-miR-140-5p STAG1 0.844753502512594 3.73722278438606e-05 -0.245728256557948 0.202447685081763 miRanda -0.140589583336782 0.00196969431862876 NA NA NA hsa-miR-181a-5p STAG1 2.29556023480783 1.8138457900616e-21 -0.245728256557948 0.202447685081763 miRNATAP -0.192745786220098 1.20678724733294e-07 NA NA NA hsa-miR-181b-5p STAG1 2.49307679431293 3.92829250217627e-20 -0.245728256557948 0.202447685081763 miRNATAP -0.13252553009663 4.94978411132215e-05 NA NA NA hsa-miR-181c-5p STAG1 1.58587920618301 1.57506918816933e-10 -0.245728256557948 0.202447685081763 miRNATAP -0.167008337103045 5.08668923082694e-06 NA NA NA hsa-miR-186-5p STAG1 1.47445398888668 3.0781726595413e-15 -0.245728256557948 0.202447685081763 mirMAP -0.129074901029091 0.00801940221455764 NA NA NA hsa-miR-199a-5p STAG1 0.592984035153911 0.0674836634175293 -0.245728256557948 0.202447685081763 miRanda -0.100125528610105 0.000472484658614487 NA NA NA hsa-miR-199b-5p STAG1 0.218704279044827 0.519493319158441 -0.245728256557948 0.202447685081763 miRanda -0.133034156616684 1.00550560273833e-06 NA NA NA hsa-miR-26b-5p STAG1 0.885393662798425 3.2116297961629e-06 -0.245728256557948 0.202447685081763 miRNAWalker2_validate -0.171395587122058 0.000450364078328837 NA NA NA hsa-miR-30a-5p STAG1 -0.878357906436456 0.000509952992366057 -0.245728256557948 0.202447685081763 MirTarget -0.121027156231127 0.000983318474982777 NA NA NA hsa-miR-30b-5p STAG1 0.800822374912712 0.000133601914525413 -0.245728256557948 0.202447685081763 MirTarget -0.173916893740682 8.56438860947271e-05 NA NA NA hsa-miR-30c-5p STAG1 0.778774633108 0.000285599212429136 -0.245728256557948 0.202447685081763 MirTarget -0.260508785613256 1.05881604466486e-09 NA NA NA hsa-miR-30e-5p STAG1 1.23904909539663 1.35561917122157e-09 -0.245728256557948 0.202447685081763 MirTarget -0.181994541574127 4.88636592618739e-05 NA NA NA hsa-miR-320a STAG1 0.438165828017084 0.0390159073347133 -0.245728256557948 0.202447685081763 miRanda -0.131709119880455 0.00285372055906094 NA NA NA hsa-miR-495-3p STAG1 -0.0847115949846082 0.763475496144456 -0.245728256557948 0.202447685081763 mirMAP -0.106383912355682 0.00137299902541505 NA NA NA hsa-miR-106a-5p TGFBR2 2.48882002962836 1.99757727374521e-12 -1.5612933795263 2.09571393414153e-11 miRTarBase;miRNATAP -0.174237668172683 2.7024970040951e-08 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 2.46782146831112 1.36171495805632e-23 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.446340567749987 1.4640429348369e-26 NA NA NA hsa-miR-107 TGFBR2 1.30977326593435 1.30372468603965e-11 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.33082940368913 1.15759545655126e-08 NA NA NA hsa-miR-130a-3p TGFBR2 2.02021855058359 1.26427102520415e-11 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.187222356261558 5.74404160623046e-07 NA NA NA hsa-miR-130b-3p TGFBR2 3.5350292994509 1.73934183852569e-27 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.279678154840768 1.9762101701233e-18 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 3.2710598467455 9.93128340539455e-27 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.302277707820119 6.79145607037112e-19 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-186-5p TGFBR2 1.47445398888668 3.0781726595413e-15 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.383453901935314 9.23917606419292e-11 NA NA NA hsa-miR-18a-5p TGFBR2 3.78535678765353 3.72446596213886e-26 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.25381972833671 2.41323249210829e-16 NA NA NA hsa-miR-19a-3p TGFBR2 3.42309334186656 3.02671914353412e-28 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.277232207383645 1.48488496649533e-16 NA NA NA hsa-miR-19b-3p TGFBR2 2.49529833021187 1.57028265846699e-23 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.351923320676886 1.03809079896527e-16 NA NA NA hsa-miR-20a-5p TGFBR2 3.15577933619191 4.19753346442454e-25 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.29433840605417 1.11976352607645e-17 NA NA NA hsa-miR-20b-5p TGFBR2 2.07706563022469 1.10107236083433e-05 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.105991731825053 9.98951097559816e-06 NA NA NA hsa-miR-21-5p TGFBR2 2.73773305747971 1.38864982139576e-43 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.1959869038848 0.000202473977886908 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-23a-3p TGFBR2 1.00493340843378 2.55313889288924e-08 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.150743460056457 0.0183024849464915 NA NA NA hsa-miR-29b-2-5p TGFBR2 0.910668640983475 0.00666655585493488 -1.5612933795263 2.09571393414153e-11 mirMAP -0.106614907621936 0.00190433915326164 NA NA NA hsa-miR-301a-3p TGFBR2 2.81024345929638 2.29784847962242e-17 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.303245579782603 4.36341401740489e-19 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-320a TGFBR2 0.438165828017084 0.0390159073347133 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.147256255771787 0.0072521693939925 NA NA NA hsa-miR-320b TGFBR2 1.55692969039548 1.41071034251915e-08 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.259785049714809 1.72104577406335e-10 NA NA NA hsa-miR-335-3p TGFBR2 3.08791651139852 5.31309869723517e-12 -1.5612933795263 2.09571393414153e-11 mirMAP -0.116451466105744 2.86501897855708e-06 NA NA NA hsa-miR-335-5p TGFBR2 1.77247705492746 2.22457658872091e-06 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.108328975461909 0.000362366652132911 NA NA NA hsa-miR-33a-3p TGFBR2 1.72765312072219 1.51784443453521e-07 -1.5612933795263 2.09571393414153e-11 mirMAP -0.218324746449326 5.80693592871469e-09 NA NA NA hsa-miR-429 TGFBR2 4.48815175680773 2.44117492218206e-17 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.182453703283022 7.13137317316041e-20 NA NA NA hsa-miR-454-3p TGFBR2 2.47234127820054 1.12878018736016e-21 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.334757039971147 2.96928366293251e-15 NA NA NA hsa-miR-501-3p TGFBR2 1.83132758513743 1.10971547702065e-10 -1.5612933795263 2.09571393414153e-11 TargetScan -0.239042838968307 1.06476001924321e-09 NA NA NA hsa-miR-508-3p TGFBR2 1.05493034310846 0.0393857095042515 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.119214194503115 1.55583026735658e-07 NA NA NA hsa-miR-590-3p TGFBR2 2.59289455139753 1.03200520972022e-21 -1.5612933795263 2.09571393414153e-11 miRanda -0.298641027773627 2.0141780556407e-13 NA NA NA hsa-miR-590-5p TGFBR2 3.18300989862077 2.06813568597893e-26 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.294796030766598 2.66958610835318e-16 NA NA NA hsa-miR-9-5p TGFBR2 1.02304182473283 0.042901377604859 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.120425377888386 8.76751437160767e-08 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 2.06460102658973 1.44784291084757e-19 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.402171657787311 8.61853387794715e-18 NA NA NA hsa-miR-93-5p TGFBR2 3.03961860136032 1.11672209617395e-24 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.345215781740609 4.92958365930485e-23 NA NA NA hsa-miR-125a-3p TRAF1 1.24490295132072 5.26925231010328e-06 -0.835440570648295 0.00151986646728419 miRanda -0.156281903972346 0.000762788031494013 NA NA NA hsa-miR-16-1-3p TRAF1 2.56983217111073 3.02262181237943e-20 -0.835440570648295 0.00151986646728419 mirMAP -0.136074471447549 0.00253509826116251 NA NA NA hsa-miR-17-3p TRAF1 2.2704817679209 1.1667437320211e-22 -0.835440570648295 0.00151986646728419 mirMAP -0.156988777448915 0.00283591981834349 NA NA NA hsa-miR-181a-2-3p TRAF1 2.19062681262366 3.81790102612782e-13 -0.835440570648295 0.00151986646728419 MirTarget -0.122488731013416 0.00298603101881274 NA NA NA hsa-miR-205-5p TRAF1 4.1389800495524 2.05488295686453e-12 -0.835440570648295 0.00151986646728419 mirMAP -0.105108191256799 4.79749863721771e-07 NA NA NA hsa-miR-30e-3p TRAF1 -0.215663037684509 0.235375122783546 -0.835440570648295 0.00151986646728419 mirMAP -0.153987730674285 0.031421434592002 NA NA NA hsa-miR-33a-3p TRAF1 1.72765312072219 1.51784443453521e-07 -0.835440570648295 0.00151986646728419 mirMAP -0.212770955455953 3.4515098574243e-07 NA NA NA hsa-miR-378a-3p TRAF1 -0.10995720000828 0.716188270032681 -0.835440570648295 0.00151986646728419 miRNAWalker2_validate -0.194254502043979 3.98876612443481e-06 NA NA NA hsa-miR-452-3p TRAF1 2.42521958420768 4.08754552781156e-07 -0.835440570648295 0.00151986646728419 mirMAP -0.1187988346955 5.99982331419692e-06 NA NA NA hsa-miR-582-3p TRAF1 0.00876844181512659 0.977126166214707 -0.835440570648295 0.00151986646728419 mirMAP -0.131362462970754 0.0017330701193284 NA NA NA hsa-miR-93-3p TRAF1 2.85383869771942 5.64481766902125e-23 -0.835440570648295 0.00151986646728419 MirTarget -0.246475373078285 2.43654004750686e-09 NA NA NA hsa-miR-940 TRAF1 3.21011374578759 2.7923171128495e-14 -0.835440570648295 0.00151986646728419 MirTarget -0.261437473921741 2.51331620492513e-17 NA NA NA hsa-miR-98-5p TRAF1 1.11154309866014 1.24143909012085e-08 -0.835440570648295 0.00151986646728419 miRNAWalker2_validate -0.433309812917729 1.00240267770758e-11 NA NA NA hsa-miR-139-5p TTK -1.52606598644743 1.20474151350665e-08 3.83401829505147 1.45533766759469e-34 miRanda -0.333191205312856 2.54094089002305e-08 NA NA NA