miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7c-5p ABCB9 -1.68954085858239 1.50987704188842e-08 0.991238956616335 7.88143292431032e-09 MirTarget -0.273859383833607 6.80741103254938e-11 NA NA NA hsa-let-7c-5p ABCC10 -1.68954085858239 1.50987704188842e-08 1.41108073348533 3.97527524225879e-22 MirTarget -0.301575187605271 5.72062761788124e-25 NA NA NA hsa-let-7c-5p ANKRD49 -1.68954085858239 1.50987704188842e-08 0.405334915402848 2.26922436427328e-05 MirTarget -0.100989362644086 4.78554482063786e-08 NA NA NA hsa-let-7c-5p BZW2 -1.68954085858239 1.50987704188842e-08 0.573615645641095 0.000216621422421312 MirTarget -0.203335965765395 1.43522953010322e-14 NA NA NA hsa-let-7c-5p CBX5 -1.68954085858239 1.50987704188842e-08 0.333339345822539 0.0652357128983962 MirTarget -0.117320573000309 2.65277493570271e-05 NA NA NA hsa-let-7c-5p CBX6 -1.68954085858239 1.50987704188842e-08 -0.162129724343296 0.501844673887141 miRNAWalker2_validate -0.147751255324137 0.0120748662714877 NA NA NA hsa-let-7a-5p CCNB2 -0.327051970960781 0.357019918333219 4.24605379412026 4.01464098176704e-50 miRNAWalker2_validate -0.449095168142698 0.00713886337518027 NA NA NA hsa-let-7b-5p CCNB2 -0.96802879335279 0.00373089178205533 4.24605379412026 4.01464098176704e-50 miRNAWalker2_validate -0.589177166241791 8.39990492744342e-09 NA NA NA hsa-let-7c-5p CCNB2 -1.68954085858239 1.50987704188842e-08 4.24605379412026 4.01464098176704e-50 miRNAWalker2_validate -0.85447689630769 1.64053136609545e-30 NA NA NA hsa-miR-23b-3p CCNB2 -0.515878675231489 0.0421006344635167 4.24605379412026 4.01464098176704e-50 miRNAWalker2_validate -0.641555640172717 9.69421048739327e-06 NA NA NA hsa-let-7b-3p CCNE2 -1.22692644840346 1.16019280976883e-12 2.04057960006681 2.32152736109171e-21 mirMAP -0.268569886454063 0.000212358107274223 NA NA NA hsa-miR-126-3p CCNE2 -0.645623595755538 0.0309477835610078 2.04057960006681 2.32152736109171e-21 miRNAWalker2_validate -0.385200741422764 5.31716743581417e-05 NA NA NA hsa-miR-26a-5p CCNE2 -0.974047564788773 0.00054935020591524 2.04057960006681 2.32152736109171e-21 miRNAWalker2_validate;miRTarBase;miRNATAP -0.488121351666366 3.8244940657208e-06 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-26b-5p CCNE2 -1.10581621769689 1.67573035523844e-05 2.04057960006681 2.32152736109171e-21 miRNATAP -0.579195472860141 1.12131120131545e-10 NA NA NA hsa-miR-30a-5p CCNE2 -0.650612306644446 0.0842725626929045 2.04057960006681 2.32152736109171e-21 miRNATAP -0.356376866932366 9.6729026873686e-08 NA NA NA hsa-miR-30c-5p CCNE2 -0.443393124598753 0.0803266140838542 2.04057960006681 2.32152736109171e-21 miRNATAP -0.190760531928298 0.0478037459406433 NA NA NA hsa-let-7c-5p CCNF -1.68954085858239 1.50987704188842e-08 2.18080981513094 2.87197331171141e-31 miRNAWalker2_validate;MirTarget -0.504449149504788 2.14481709469935e-28 NA NA NA hsa-let-7c-5p CDC25A -1.68954085858239 1.50987704188842e-08 1.93906279371787 1.67520037780079e-18 MirTarget -0.51524439141821 8.99192957021977e-21 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules progression liver cancer hsa-miR-122-5p CDK4 -1.16942005732046 0.00180042238458308 0.661857656453694 0.00018865319720684 miRNAWalker2_validate -0.116994239033144 4.65868213756134e-11 NA NA NA hsa-miR-145-5p CDK4 -1.50494087761311 7.70058378639819e-07 0.661857656453694 0.00018865319720684 miRNAWalker2_validate;miRTarBase -0.153089865179612 2.59222750442516e-09 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control lung squamous cell cancer hsa-miR-193b-3p CDK4 -0.157435053596259 0.478885670141978 0.661857656453694 0.00018865319720684 miRNAWalker2_validate -0.152018771778108 2.97527104247713e-06 NA NA NA hsa-miR-195-5p CDK4 -1.87601302054107 4.90688075723255e-17 0.661857656453694 0.00018865319720684 miRNAWalker2_validate;miRTarBase -0.181976803431634 3.34979886785679e-14 NA NA NA hsa-let-7c-5p CECR6 -1.68954085858239 1.50987704188842e-08 0.374844820458418 0.0524552592216039 MirTarget -0.145473456803039 0.00240190908970139 NA NA NA hsa-let-7c-5p CEP135 -1.68954085858239 1.50987704188842e-08 0.251470939056949 0.0682077134507916 MirTarget -0.128226314386056 0.000108910151993848 NA NA NA hsa-let-7c-5p CERCAM -1.68954085858239 1.50987704188842e-08 -0.186186086973668 0.495133501678444 MirTarget -0.138379572621477 0.0336460392243724 NA NA NA hsa-let-7c-5p CNOT3 -1.68954085858239 1.50987704188842e-08 0.581678172762677 1.16546961972114e-05 miRNAWalker2_validate -0.137147538185394 1.56310657094192e-15 NA NA NA hsa-let-7c-5p COL24A1 -1.68954085858239 1.50987704188842e-08 2.05249239031158 5.03284577068849e-08 MirTarget -0.322074263479633 0.000715997285583281 NA NA NA hsa-miR-148a-5p CSNK1E -0.736021593009622 0.000162063386273975 0.593983531231951 0.000191743644667552 miRNATAP -0.245152102120518 4.84178312131527e-20 NA NA NA hsa-miR-195-3p CSNK1E -1.09796561152863 9.48883739731789e-09 0.593983531231951 0.000191743644667552 miRNATAP -0.104078083921822 9.86380539775099e-06 NA NA NA hsa-let-7c-5p CSNK2A1 -1.68954085858239 1.50987704188842e-08 0.30176253273244 0.0347783476169454 miRNAWalker2_validate -0.118081213291704 8.22763425873157e-10 NA NA NA hsa-let-7c-5p CYB561D1 -1.68954085858239 1.50987704188842e-08 1.34626100829999 4.43388633145036e-20 MirTarget -0.301970204704956 9.88527966067797e-19 NA NA NA hsa-let-7c-5p DAGLA -1.68954085858239 1.50987704188842e-08 1.12939076112517 2.190969547813e-05 MirTarget -0.448159334629883 3.0762615596391e-12 NA NA NA hsa-let-7c-5p DCAF15 -1.68954085858239 1.50987704188842e-08 0.442246448422951 0.000364005550600845 MirTarget -0.101335020598812 8.14528075667905e-07 NA NA NA hsa-let-7c-5p DCLRE1B -1.68954085858239 1.50987704188842e-08 0.709496503350255 2.25225566923317e-10 MirTarget -0.114154467810837 3.88086854753268e-06 NA NA NA hsa-let-7c-5p DCTN5 -1.68954085858239 1.50987704188842e-08 0.0965483764280854 0.48293773796035 miRNAWalker2_validate -0.137050765086275 4.53587636121251e-14 NA NA NA hsa-let-7c-5p DLGAP4 -1.68954085858239 1.50987704188842e-08 0.605600909975229 0.000251127369670399 MirTarget -0.178146649866821 2.96101504576869e-17 NA NA NA hsa-let-7c-5p DNAJC6 -1.68954085858239 1.50987704188842e-08 2.29462936903977 6.91672532785205e-20 miRNAWalker2_validate -0.383639320555159 2.04522452132374e-09 NA NA NA hsa-let-7c-5p DOT1L -1.68954085858239 1.50987704188842e-08 0.579927767140162 0.000333291558586964 miRNAWalker2_validate -0.149931329292625 1.58114052310453e-07 NA NA NA hsa-let-7c-5p DZIP1L -1.68954085858239 1.50987704188842e-08 -0.131770400093236 0.571473660028117 MirTarget -0.153365860262585 0.00940939013868638 NA NA NA hsa-let-7c-5p E2F2 -1.68954085858239 1.50987704188842e-08 2.82909533645535 7.27892221899994e-33 MirTarget -0.605641654221748 3.1290897462579e-23 NA NA NA hsa-let-7c-5p E2F5 -1.68954085858239 1.50987704188842e-08 0.707771265508717 0.000820753384545708 MirTarget -0.228095461415917 1.04748751614991e-05 NA NA NA hsa-let-7c-5p ELF4 -1.68954085858239 1.50987704188842e-08 -0.175364079629832 0.381485099057181 MirTarget -0.135890153838811 0.0038215332500121 NA NA NA hsa-let-7c-5p ESPL1 -1.68954085858239 1.50987704188842e-08 1.8845901248323 9.45585981305183e-13 MirTarget -0.45417008213531 3.14084416633658e-12 NA NA NA hsa-let-7c-5p FAM103A1 -1.68954085858239 1.50987704188842e-08 0.497993218221336 2.20335476122997e-05 miRNAWalker2_validate -0.146424524120768 3.23230414839587e-13 NA NA NA hsa-let-7c-5p FAM104A -1.68954085858239 1.50987704188842e-08 0.388160857459528 0.000855778955841372 MirTarget -0.10225823892978 1.28559987604419e-10 NA NA NA hsa-let-7c-5p FANCI -1.68954085858239 1.50987704188842e-08 2.59075502638745 1.99577570405368e-36 miRNAWalker2_validate -0.553264627084958 3.44910425383123e-29 NA NA NA hsa-let-7a-3p FBXO32 -0.577987669365033 0.000183975424113604 1.48279928430406 9.90971944945453e-11 mirMAP -0.38916471208738 0.000151658861853164 NA NA NA hsa-let-7a-5p FBXO32 -0.327051970960781 0.357019918333219 1.48279928430406 9.90971944945453e-11 TargetScan;miRNATAP -0.408608217233986 0.000583968456002134 NA NA NA hsa-let-7b-3p FBXO32 -1.22692644840346 1.16019280976883e-12 1.48279928430406 9.90971944945453e-11 mirMAP -0.20693354019583 0.00476775913146388 NA NA NA hsa-let-7b-5p FBXO32 -0.96802879335279 0.00373089178205533 1.48279928430406 9.90971944945453e-11 miRNATAP -0.3485130972578 2.09750759880799e-06 NA NA NA hsa-miR-101-3p FBXO32 -1.46123406387954 1.21829669234236e-05 1.48279928430406 9.90971944945453e-11 miRNATAP -0.457433236880843 8.98934153612009e-09 NA NA NA hsa-miR-139-5p FBXO32 -2.09676091714612 6.66914773036538e-19 1.48279928430406 9.90971944945453e-11 miRanda -0.248867014578252 2.84390884190769e-06 NA NA NA hsa-miR-144-3p FBXO32 -2.96007100498645 6.66721571532497e-27 1.48279928430406 9.90971944945453e-11 miRNATAP -0.123870260990645 0.00112473386271035 NA NA NA hsa-miR-192-3p FBXO32 -0.588507789732336 0.00347194985668043 1.48279928430406 9.90971944945453e-11 mirMAP -0.416011661149065 1.26508248581647e-11 NA NA NA hsa-miR-19a-3p FBXO32 1.0061601759795 2.83495198956092e-05 1.48279928430406 9.90971944945453e-11 miRNATAP -0.168246835317001 0.0023625887932764 NA NA NA hsa-miR-19b-3p FBXO32 0.594150523170887 0.0147430795009342 1.48279928430406 9.90971944945453e-11 miRNATAP -0.23913099726224 0.000520544202177325 NA NA NA hsa-miR-23b-3p FBXO32 -0.515878675231489 0.0421006344635167 1.48279928430406 9.90971944945453e-11 miRNATAP -0.328405111949567 0.00160688452755544 NA NA NA hsa-miR-26a-2-3p FBXO32 -0.571140420534787 0.000118629480819338 1.48279928430406 9.90971944945453e-11 mirMAP -0.333247401763822 2.260919464156e-05 NA NA NA hsa-miR-26a-5p FBXO32 -0.974047564788773 0.00054935020591524 1.48279928430406 9.90971944945453e-11 mirMAP -0.749573981541152 7.62418790634323e-13 NA NA NA hsa-miR-26b-5p FBXO32 -1.10581621769689 1.67573035523844e-05 1.48279928430406 9.90971944945453e-11 mirMAP -0.606502689591703 1.86714840609046e-11 NA NA NA hsa-miR-27b-3p FBXO32 -0.818409565949745 0.00285268618949836 1.48279928430406 9.90971944945453e-11 miRNATAP -0.516688019767081 9.38353902752944e-08 NA NA NA hsa-miR-3170 FBXO32 -0.470478715446345 0.0139574107770877 1.48279928430406 9.90971944945453e-11 mirMAP -0.215940283160539 0.00023072043114614 NA NA NA hsa-miR-320a FBXO32 0.320550805632269 0.200242425283382 1.48279928430406 9.90971944945453e-11 mirMAP -0.166037304867455 0.0339564133821316 NA NA NA hsa-miR-335-3p FBXO32 -0.300128876431033 0.195795452113093 1.48279928430406 9.90971944945453e-11 mirMAP -0.4095666127518 1.39124567217462e-10 NA NA NA hsa-miR-33a-3p FBXO32 -0.656068509744081 2.13977018383522e-05 1.48279928430406 9.90971944945453e-11 mirMAP -0.251503190503819 0.000398106613167281 NA NA NA hsa-miR-33a-5p FBXO32 -0.741521864085914 0.000142198514633367 1.48279928430406 9.90971944945453e-11 mirMAP -0.138776931626495 0.0278057790087512 NA NA NA hsa-miR-369-3p FBXO32 -0.721025668664511 0.0146753208941748 1.48279928430406 9.90971944945453e-11 mirMAP -0.111599478190871 0.00454380231866122 NA NA NA hsa-miR-450b-5p FBXO32 -1.36245759237135 1.86254952885994e-13 1.48279928430406 9.90971944945453e-11 mirMAP -0.269009276779683 5.72016259812758e-05 NA NA NA hsa-miR-455-3p FBXO32 -1.371435768437 4.74592694777696e-08 1.48279928430406 9.90971944945453e-11 mirMAP -0.352227247366592 2.18536409018519e-08 NA NA NA hsa-miR-590-3p FBXO32 -0.465059977165438 0.000171727547585632 1.48279928430406 9.90971944945453e-11 mirMAP -0.361384615984933 0.000307325389584702 NA NA NA hsa-miR-628-5p FBXO32 -0.702039671339761 1.1759316579478e-06 1.48279928430406 9.90971944945453e-11 miRNATAP -0.471220079072473 1.40207611609196e-08 NA NA NA hsa-miR-654-3p FBXO32 -1.74378017184668 6.53546756908015e-09 1.48279928430406 9.90971944945453e-11 mirMAP -0.139656043310257 0.00030923145150098 NA NA NA hsa-let-7c-5p FIGNL2 -1.68954085858239 1.50987704188842e-08 1.37926207117515 6.82028863420232e-07 MirTarget -0.440097760520244 1.38345498901364e-10 NA NA NA hsa-let-7c-5p FKBP10 -1.68954085858239 1.50987704188842e-08 0.115768615688021 0.661380001351676 miRNAWalker2_validate -0.199648875231396 0.00073149848136377 NA NA NA hsa-let-7c-5p GARS -1.68954085858239 1.50987704188842e-08 0.538238370953771 0.00170268242646844 miRNAWalker2_validate -0.161680244524281 2.42584352025334e-13 NA NA NA hsa-let-7c-5p GGA3 -1.68954085858239 1.50987704188842e-08 0.718612844841657 6.17912486049022e-09 MirTarget -0.172818653690179 3.02949988341581e-20 NA NA NA hsa-let-7c-5p GRPEL2 -1.68954085858239 1.50987704188842e-08 0.655326031687082 5.94690679645672e-09 MirTarget -0.166885706843202 3.33866025922138e-20 NA NA NA hsa-let-7c-5p GSK3A -1.68954085858239 1.50987704188842e-08 0.341902209204734 0.0195022102498726 miRNAWalker2_validate -0.101608466684152 2.71277295275603e-11 NA NA NA hsa-let-7c-5p HIF1AN -1.68954085858239 1.50987704188842e-08 0.594982384451582 1.34227187121991e-05 MirTarget -0.147609310389359 4.12097290603693e-12 NA NA NA hsa-let-7c-5p HMGA1 -1.68954085858239 1.50987704188842e-08 1.51110543394506 7.20352581076939e-11 MirTarget -0.517651637702838 1.10830470288536e-32 NA NA NA hsa-let-7c-5p HMGA2 -1.68954085858239 1.50987704188842e-08 1.07664720136568 0.0204312015428862 miRNAWalker2_validate;miRTarBase;MirTarget -0.682135030438129 2.57681307834063e-09 NA NA NA hsa-let-7a-2-3p HOMER1 -1.19805958982378 2.93493786900366e-08 -0.0861934913747715 0.771161348653316 MirTarget -0.253281287503719 0.000175917559555184 NA NA NA hsa-miR-139-5p HOMER1 -2.09676091714612 6.66914773036538e-19 -0.0861934913747715 0.771161348653316 miRanda -0.267156507727504 0.000114980968432196 NA NA NA hsa-miR-148a-3p HOMER1 -0.717420039165734 0.0612127441982528 -0.0861934913747715 0.771161348653316 MirTarget -0.666575262467855 1.35873064627191e-12 NA NA NA hsa-miR-22-3p HOMER1 -0.617496055386013 0.121463375636348 -0.0861934913747715 0.771161348653316 MirTarget -0.523755417860633 0.000127608919369781 NA NA NA hsa-miR-30c-1-3p HOMER1 -1.38398707165087 1.45891735127352e-16 -0.0861934913747715 0.771161348653316 MirTarget -0.187593390524113 0.0262223775681616 NA NA NA hsa-miR-30c-2-3p HOMER1 -1.40759440532577 1.12666939431108e-10 -0.0861934913747715 0.771161348653316 MirTarget -0.194705750340817 0.0129304241676584 NA NA NA hsa-miR-374a-5p HOMER1 0.023238412093459 0.882444192528889 -0.0861934913747715 0.771161348653316 MirTarget -0.417893362731193 0.00411476681675461 NA NA NA hsa-miR-374b-5p HOMER1 -0.29608886825605 0.086473312355299 -0.0861934913747715 0.771161348653316 MirTarget;mirMAP -0.303566368791152 0.0300109000858296 NA NA NA hsa-miR-548b-3p HOMER1 0.0342046829353997 0.882257542861142 -0.0861934913747715 0.771161348653316 PITA -0.338054258669289 3.73274922664469e-08 NA NA NA hsa-miR-30c-5p HSP90AA1 -0.443393124598753 0.0803266140838542 0.36559811661269 0.111912077389365 miRNAWalker2_validate -0.202157986427488 1.9883621574863e-07 NA NA NA hsa-miR-30e-5p HSP90AA1 -0.621355151567112 0.0486782567561215 0.36559811661269 0.111912077389365 miRNAWalker2_validate -0.241505661403756 4.10597516818342e-08 NA NA NA hsa-let-7c-5p IGDCC3 -1.68954085858239 1.50987704188842e-08 1.94380284142876 7.72275571919619e-06 MirTarget -0.631731378965707 2.0749328122547e-09 NA NA NA hsa-let-7c-5p IGDCC4 -1.68954085858239 1.50987704188842e-08 1.65675663209539 2.29631116863094e-06 MirTarget -0.669489234913257 2.47646431218122e-14 NA NA NA hsa-let-7c-5p IGF2BP1 -1.68954085858239 1.50987704188842e-08 4.94614385924985 2.07169653535367e-15 MirTarget -1.64306107284158 3.32791048956517e-27 NA NA NA hsa-let-7c-5p IGF2BP2 -1.68954085858239 1.50987704188842e-08 1.12766760008732 0.00468932843452932 MirTarget -0.66967665441044 5.02308301505737e-12 NA NA NA hsa-let-7c-5p IGF2BP3 -1.68954085858239 1.50987704188842e-08 2.40851259258886 4.1465647848271e-12 MirTarget -0.792505127678787 9.55879338832913e-21 NA NA NA hsa-let-7c-5p IP6K1 -1.68954085858239 1.50987704188842e-08 0.895348813538712 2.70166444246378e-10 miRNAWalker2_validate -0.136554103095589 1.44616222053653e-11 NA NA NA hsa-miR-192-5p ITGAV -0.454202244661779 0.198724713129436 0.395748984344864 0.0694708940030567 miRNAWalker2_validate;MirTarget -0.344370980466671 1.89013250176103e-15 NA NA NA hsa-miR-32-5p ITGAV 0.0731835904837661 0.713088011613935 0.395748984344864 0.0694708940030567 miRNAWalker2_validate;MirTarget;miRNATAP -0.274975166498264 1.42681810268729e-06 NA NA NA hsa-miR-328-3p ITGAV -0.52603812078889 0.000660205613650353 0.395748984344864 0.0694708940030567 MirTarget -0.132063082039302 0.0363785445433637 NA NA NA hsa-miR-33a-3p ITGAV -0.656068509744081 2.13977018383522e-05 0.395748984344864 0.0694708940030567 MirTarget -0.155984185219414 0.00158654023964867 NA NA NA hsa-miR-374a-5p ITGAV 0.023238412093459 0.882444192528889 0.395748984344864 0.0694708940030567 mirMAP -0.174068026833335 0.0257907946480254 NA NA NA hsa-miR-92a-3p ITGAV 0.217702717296989 0.539507903859097 0.395748984344864 0.0694708940030567 MirTarget;miRNATAP -0.257814482101981 1.80305424957411e-06 NA NA NA hsa-let-7c-5p KCTD17 -1.68954085858239 1.50987704188842e-08 0.879761311687647 0.000986273834860236 MirTarget -0.481480851735286 2.15992968805401e-14 NA NA NA hsa-let-7c-5p KIAA1429 -1.68954085858239 1.50987704188842e-08 0.541262520917014 0.000194389297441795 MirTarget -0.12056072911504 1.72477615472835e-08 NA NA NA hsa-let-7c-5p KLHL31 -1.68954085858239 1.50987704188842e-08 1.25796713578689 2.27487388081402e-11 MirTarget -0.113451025803371 0.019099409616493 NA NA NA hsa-let-7c-5p LBR -1.68954085858239 1.50987704188842e-08 0.395517861277438 0.020797461548537 MirTarget -0.180026392917426 3.89595826197494e-13 NA NA NA hsa-let-7c-5p LIMD2 -1.68954085858239 1.50987704188842e-08 -0.217620482776087 0.312676139321178 MirTarget -0.218360777157729 1.04445562421957e-05 NA NA NA hsa-let-7c-5p LIMK2 -1.68954085858239 1.50987704188842e-08 0.874106626047133 6.3595111207383e-06 MirTarget -0.236593103071651 4.17089447540952e-10 NA NA NA hsa-let-7c-5p LIN28B -1.68954085858239 1.50987704188842e-08 2.3102402650782 5.04049627368145e-05 MirTarget -0.942677952234562 8.19224435516587e-12 NA NA NA hsa-let-7c-5p MDFI -1.68954085858239 1.50987704188842e-08 1.53851262770587 5.94014697043213e-07 MirTarget -0.449944709746608 5.78696252416618e-09 NA NA NA hsa-let-7c-5p MDM4 -1.68954085858239 1.50987704188842e-08 0.728344364384513 1.00708257262991e-06 MirTarget -0.16378523997819 4.65469630843185e-10 NA NA NA hsa-let-7c-5p MGAT4A -1.68954085858239 1.50987704188842e-08 0.100243209405842 0.513028079284127 MirTarget -0.139105957783091 3.9224788202799e-07 NA NA NA hsa-let-7c-5p NAP1L1 -1.68954085858239 1.50987704188842e-08 0.475502416282159 0.0214404925355764 MirTarget -0.248793874030014 2.70783118256391e-22 NA NA NA hsa-let-7c-5p NME6 -1.68954085858239 1.50987704188842e-08 0.618678061757553 1.61568442378179e-09 MirTarget -0.214598920327561 3.81766152781017e-26 NA NA NA hsa-let-7c-5p NPTX1 -1.68954085858239 1.50987704188842e-08 0.85574621052234 0.010109299977456 miRNAWalker2_validate -0.349636575478964 3.44078587361936e-05 NA NA NA hsa-let-7c-5p NRARP -1.68954085858239 1.50987704188842e-08 0.777492063872217 1.44978685584244e-05 MirTarget -0.111854005713575 0.00649160992703926 NA NA NA hsa-let-7b-5p NRAS -0.96802879335279 0.00373089178205533 0.307754633490381 0.0383887310553194 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.105903409272711 8.57245668973746e-05 20607356 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells glioblastoma hsa-miR-126-5p NRAS -0.43105584244784 0.0522578049882819 0.307754633490381 0.0383887310553194 mirMAP -0.145651073417946 0.000106824688349933 NA NA NA hsa-miR-145-5p NRAS -1.50494087761311 7.70058378639819e-07 0.307754633490381 0.0383887310553194 miRNAWalker2_validate;MirTarget;miRNATAP -0.120395847533196 1.03194548202048e-08 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-22-3p NRAS -0.617496055386013 0.121463375636348 0.307754633490381 0.0383887310553194 MirTarget;miRNATAP -0.287363482934569 1.84836871548684e-14 NA NA NA hsa-miR-29a-3p NRAS -0.869351287663013 0.00819631513056888 0.307754633490381 0.0383887310553194 miRNATAP -0.111209986118726 0.000497462508043792 NA NA NA hsa-miR-29b-3p NRAS -0.365229530043335 0.167773189797398 0.307754633490381 0.0383887310553194 miRNATAP -0.163441778679427 1.31476396622707e-08 NA NA NA hsa-miR-29c-3p NRAS -1.43984354699383 7.978719618139e-07 0.307754633490381 0.0383887310553194 miRNATAP -0.195416271463693 3.04370398757482e-15 NA NA NA hsa-miR-664a-3p NRAS 0.484162385400165 0.0126214050719088 0.307754633490381 0.0383887310553194 MirTarget -0.123577371649095 9.58480979576424e-06 NA NA NA hsa-let-7c-5p PAG1 -1.68954085858239 1.50987704188842e-08 -0.0602256750483336 0.772875477789816 MirTarget -0.11049170694399 0.0212818061791696 NA NA NA hsa-let-7c-5p PAK4 -1.68954085858239 1.50987704188842e-08 0.318858779428986 0.0501993285931995 miRNAWalker2_validate -0.146202847790971 7.66415471826461e-10 NA NA NA hsa-let-7c-5p PARD6B -1.68954085858239 1.50987704188842e-08 -0.105170692851246 0.450506136773288 MirTarget -0.142218447562304 1.26822558335396e-06 NA NA NA hsa-let-7c-5p PCGF3 -1.68954085858239 1.50987704188842e-08 0.154045085968931 0.286503948195231 miRNAWalker2_validate;MirTarget -0.113853768613945 1.4497220623856e-08 NA NA NA hsa-let-7c-5p PLAGL2 -1.68954085858239 1.50987704188842e-08 0.334777494649288 0.0143407906488602 MirTarget -0.167081915992385 2.69511671900005e-09 NA NA NA hsa-let-7c-5p PLEKHG6 -1.68954085858239 1.50987704188842e-08 0.0348871766914134 0.899388048685362 MirTarget -0.203069992909591 0.0029441217881029 NA NA NA hsa-let-7c-5p PLXND1 -1.68954085858239 1.50987704188842e-08 0.683355737688998 0.000393044339050253 MirTarget -0.121343527002517 5.62640054248759e-05 NA NA NA hsa-let-7c-5p PRAF2 -1.68954085858239 1.50987704188842e-08 0.461092238774232 0.00160360145093861 miRNAWalker2_validate -0.114609565008073 7.36690639861184e-05 NA NA NA hsa-let-7b-3p PRKAA2 -1.22692644840346 1.16019280976883e-12 0.912177859760645 0.0142293087185336 mirMAP -0.385703556647416 0.00114946510675726 NA NA NA hsa-let-7b-5p PRKAA2 -0.96802879335279 0.00373089178205533 0.912177859760645 0.0142293087185336 miRNAWalker2_validate;MirTarget -0.399590032732691 0.000857606952583238 NA NA NA hsa-let-7c-5p PRKAA2 -1.68954085858239 1.50987704188842e-08 0.912177859760645 0.0142293087185336 MirTarget -0.323478962357034 0.000457014156060023 NA NA NA hsa-miR-125b-5p PRKAA2 -1.35495911215137 1.1424656166414e-07 0.912177859760645 0.0142293087185336 miRNATAP -0.468131740207186 2.58447444857568e-05 NA NA NA hsa-miR-126-5p PRKAA2 -0.43105584244784 0.0522578049882819 0.912177859760645 0.0142293087185336 mirMAP -0.353829124273961 0.0349255565875956 NA NA NA hsa-miR-130a-3p PRKAA2 -1.55985490062358 3.64462879913452e-12 0.912177859760645 0.0142293087185336 MirTarget -0.261650172386151 0.00937218581418371 NA NA NA hsa-miR-130b-3p PRKAA2 0.699096641799525 0.000517993008700766 0.912177859760645 0.0142293087185336 MirTarget -0.39214943725483 8.93727722972995e-05 NA NA NA hsa-miR-139-5p PRKAA2 -2.09676091714612 6.66914773036538e-19 0.912177859760645 0.0142293087185336 mirMAP -0.243840459298225 0.00500077362975578 NA NA NA hsa-miR-144-3p PRKAA2 -2.96007100498645 6.66721571532497e-27 0.912177859760645 0.0142293087185336 mirMAP -0.251212728741441 4.29127796324217e-05 NA NA NA hsa-miR-16-2-3p PRKAA2 -0.0394835026764384 0.798816363987396 0.912177859760645 0.0142293087185336 mirMAP -0.457570769127741 0.000536483503983079 NA NA NA hsa-miR-195-3p PRKAA2 -1.09796561152863 9.48883739731789e-09 0.912177859760645 0.0142293087185336 mirMAP -0.528536254111941 2.17986726272341e-08 NA NA NA hsa-miR-203a-3p PRKAA2 -1.37393518909882 0.000860575325703417 0.912177859760645 0.0142293087185336 MirTarget -0.179382015471783 0.000540688920660811 NA NA NA hsa-miR-217 PRKAA2 1.06704797642394 0.051017115707544 0.912177859760645 0.0142293087185336 mirMAP -0.174781811555677 3.64856315207684e-07 NA NA NA hsa-miR-22-5p PRKAA2 -0.660061686153562 0.000831737720196228 0.912177859760645 0.0142293087185336 mirMAP -0.407034919675641 0.000519823954254811 NA NA NA hsa-miR-26a-5p PRKAA2 -0.974047564788773 0.00054935020591524 0.912177859760645 0.0142293087185336 mirMAP -0.782511241662933 5.79168652076068e-06 NA NA NA hsa-miR-30e-3p PRKAA2 -1.19022804830372 8.67884181447538e-05 0.912177859760645 0.0142293087185336 MirTarget -0.527801395071765 0.000287963362506242 NA NA NA hsa-miR-30e-5p PRKAA2 -0.621355151567112 0.0486782567561215 0.912177859760645 0.0142293087185336 MirTarget -0.438345582649116 0.0139749918956882 NA NA NA hsa-miR-576-5p PRKAA2 -0.373089522417638 0.0200717266650249 0.912177859760645 0.0142293087185336 mirMAP -0.339109435921254 0.0119064555477781 NA NA NA hsa-miR-628-3p PRKAA2 -0.984440203422219 4.35700334946884e-08 0.912177859760645 0.0142293087185336 mirMAP -0.30159363325766 0.00298084973196401 NA NA NA hsa-let-7c-5p PRRX1 -1.68954085858239 1.50987704188842e-08 2.07119886549828 3.71005136642422e-15 MirTarget -0.352682612593982 1.66283334492681e-07 NA NA NA hsa-let-7c-5p PTGES2 -1.68954085858239 1.50987704188842e-08 0.511916678721084 0.00178476712097876 miRNAWalker2_validate -0.150018737330616 5.00669169745312e-08 NA NA NA hsa-let-7c-5p PTK2 -1.68954085858239 1.50987704188842e-08 0.59762899765019 0.000326068828692912 miRNAWalker2_validate -0.111526582483996 6.85487252665759e-06 NA NA NA hsa-let-7c-5p RAB11FIP4 -1.68954085858239 1.50987704188842e-08 1.54625231848075 7.45158055326446e-13 MirTarget -0.366743712732836 4.57221998622098e-15 NA NA NA hsa-let-7c-5p RAB34 -1.68954085858239 1.50987704188842e-08 0.365489347283576 0.207026453142142 miRNAWalker2_validate -0.284015184457008 2.48793947860605e-05 NA NA NA hsa-miR-101-3p RAC1 -1.46123406387954 1.21829669234236e-05 0.21485969874295 0.254640883592495 miRNAWalker2_validate;MirTarget -0.160619583159355 2.13421294167009e-10 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-let-7c-5p RAD18 -1.68954085858239 1.50987704188842e-08 0.740859419985891 3.84047116380844e-12 MirTarget -0.162229147179546 3.03633151346655e-12 NA NA NA hsa-let-7c-5p RAPGEFL1 -1.68954085858239 1.50987704188842e-08 0.520531026560424 0.00706057338957372 miRNAWalker2_validate -0.104672283482989 0.0263816556863234 NA NA NA hsa-let-7c-5p RFWD3 -1.68954085858239 1.50987704188842e-08 0.424314207092235 0.00110661159039305 miRNAWalker2_validate -0.125524002210606 2.35908018598628e-08 NA NA NA hsa-let-7c-5p RFX5 -1.68954085858239 1.50987704188842e-08 1.21957312797816 5.92800907717475e-15 MirTarget -0.142572635491316 1.08560294572442e-06 NA NA NA hsa-let-7c-5p RPL18A -1.68954085858239 1.50987704188842e-08 0.290959674517572 0.140304209229754 miRNAWalker2_validate -0.183702992224943 7.94319049679231e-09 NA NA NA hsa-let-7c-5p RPS13 -1.68954085858239 1.50987704188842e-08 0.0445968697703121 0.829665678989858 miRNAWalker2_validate -0.10218446432348 4.42586947280731e-05 NA NA NA hsa-let-7c-5p RPS24 -1.68954085858239 1.50987704188842e-08 0.268065999574048 0.284344378314573 miRNAWalker2_validate -0.196549606512263 3.44029551262791e-09 NA NA NA hsa-let-7c-5p SEMA3F -1.68954085858239 1.50987704188842e-08 1.45418840321867 2.08892804658125e-22 MirTarget -0.234818872817101 1.05143991596871e-14 NA NA NA hsa-let-7c-5p SEMA4F -1.68954085858239 1.50987704188842e-08 0.994996976710637 0.000121303115462673 MirTarget -0.273087481441457 1.81190606874631e-05 NA NA NA hsa-let-7c-5p SF3B4 -1.68954085858239 1.50987704188842e-08 1.03016511000509 9.28595474618259e-10 miRNAWalker2_validate -0.218936273994718 1.52946844995903e-18 NA NA NA hsa-miR-21-5p SKP2 1.4919401794027 0.000788384815490386 0.44476793319665 0.0158308925122935 miRNAWalker2_validate;MirTarget -0.199555879642397 0.00262016397392478 NA NA NA hsa-miR-30b-5p SKP2 -0.559325140138188 0.0329754757780673 0.44476793319665 0.0158308925122935 MirTarget;miRNATAP -0.240712598784266 0.000463630582388284 NA NA NA hsa-let-7c-5p SLC10A3 -1.68954085858239 1.50987704188842e-08 0.330285215361592 0.0266140349780051 miRNAWalker2_validate -0.182712057163013 5.67345250226885e-11 NA NA NA hsa-let-7c-5p SLC17A9 -1.68954085858239 1.50987704188842e-08 0.510380604851844 0.0327707978858246 MirTarget -0.198870581493571 6.13429852972486e-05 NA NA NA hsa-let-7c-5p SMARCC1 -1.68954085858239 1.50987704188842e-08 0.461459643196386 0.00216746748979469 miRNAWalker2_validate -0.12781175289705 2.68001045795896e-10 NA NA NA hsa-let-7c-5p SMARCD1 -1.68954085858239 1.50987704188842e-08 0.635148315769105 1.15161801228421e-05 miRNAWalker2_validate -0.177640467487771 1.94594245173065e-21 NA NA NA hsa-let-7c-5p SMCR8 -1.68954085858239 1.50987704188842e-08 0.451063709807108 0.000898577588914177 MirTarget -0.122565100231006 5.4902514084137e-07 NA NA NA hsa-let-7c-5p SOX13 -1.68954085858239 1.50987704188842e-08 0.723604334775274 2.24918781880739e-06 MirTarget -0.124273877815759 8.64473078600962e-07 NA NA NA hsa-let-7c-5p STX3 -1.68954085858239 1.50987704188842e-08 0.25994612249258 0.125966583133745 MirTarget -0.200597820665899 1.7582165585329e-08 NA NA NA hsa-let-7c-5p SUB1 -1.68954085858239 1.50987704188842e-08 0.587407814244546 0.00127269019438968 MirTarget -0.151812387295251 1.54400818436745e-12 NA NA NA hsa-let-7c-5p TAZ -1.68954085858239 1.50987704188842e-08 0.963465295732379 3.44215011571383e-12 miRNAWalker2_validate -0.160843910434223 3.98057075434146e-10 NA NA NA hsa-let-7c-5p TBC1D13 -1.68954085858239 1.50987704188842e-08 0.867668027214027 1.22700162968076e-08 MirTarget -0.174153765242454 1.81958533488793e-10 NA NA NA hsa-let-7c-5p TBKBP1 -1.68954085858239 1.50987704188842e-08 0.909325839079895 2.09739488358389e-08 MirTarget -0.255902300442293 6.22257358099485e-12 NA NA NA hsa-let-7c-5p TMEM165 -1.68954085858239 1.50987704188842e-08 0.56236723192802 0.000306702925963422 miRNAWalker2_validate -0.144842845795178 2.038268418118e-08 NA NA NA hsa-let-7c-5p TMEM184B -1.68954085858239 1.50987704188842e-08 0.875920522033872 3.55365375756141e-08 miRNAWalker2_validate -0.170532146688534 1.19223629021959e-11 NA NA NA hsa-let-7c-5p TRIM67 -1.68954085858239 1.50987704188842e-08 0.510698181746218 0.0336973893051137 MirTarget -0.221979298256235 0.000181660256380273 NA NA NA hsa-let-7c-5p TRIM71 -1.68954085858239 1.50987704188842e-08 1.9230280574691 5.52611947643803e-06 miRNAWalker2_validate;MirTarget -0.78785120052045 2.91205218598371e-15 NA NA NA hsa-let-7c-5p TTLL4 -1.68954085858239 1.50987704188842e-08 1.0954744416699 2.01944048908733e-08 MirTarget -0.450426278450796 7.57793283588566e-28 NA NA NA hsa-let-7c-5p UBA52 -1.68954085858239 1.50987704188842e-08 0.27931345817022 0.229286216315547 miRNAWalker2_validate -0.106594975606236 0.000134675405654401 NA NA NA hsa-let-7c-5p ZC3H3 -1.68954085858239 1.50987704188842e-08 1.06290760952576 3.83496295793674e-11 MirTarget -0.199043730435108 1.27659419619969e-11 NA NA NA hsa-let-7c-5p ZNF512B -1.68954085858239 1.50987704188842e-08 0.962783417746506 3.03525970544782e-10 MirTarget -0.178134616117144 1.43198078159576e-10 NA NA NA hsa-let-7c-5p ZNF526 -1.68954085858239 1.50987704188842e-08 0.697265832512149 8.77600309619632e-12 miRNAWalker2_validate -0.147571959257241 1.3126555892882e-15 NA NA NA hsa-let-7c-5p ZNF581 -1.68954085858239 1.50987704188842e-08 1.08385357112 5.42144478670162e-13 miRNAWalker2_validate -0.315580993313553 1.10992003321011e-23 NA NA NA hsa-let-7c-5p ZNF710 -1.68954085858239 1.50987704188842e-08 0.305585701339962 0.128703038708545 MirTarget -0.120535446215635 0.0125911174137927 NA NA NA