miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-3p ABI3BP 0.466622567891891 3.70886257943079e-07 -2.67294165600819 1.2145292807081e-35 miRNATAP -0.599375093631193 3.85940561432118e-13 NA NA NA hsa-miR-107 ABI3BP 0.678998026350662 2.56224148930538e-16 -2.67294165600819 1.2145292807081e-35 miRanda -0.424841508938404 3.28298834340301e-06 NA NA NA hsa-miR-181a-5p ABI3BP 0.635863607630183 6.72486918157744e-11 -2.67294165600819 1.2145292807081e-35 miRNATAP -0.4117887706244 1.24568291566364e-07 NA NA NA hsa-miR-181b-5p ABI3BP 1.22749257795094 1.21998198830919e-27 -2.67294165600819 1.2145292807081e-35 miRNATAP -0.505516171942284 8.4427136016198e-15 NA NA NA hsa-miR-181c-5p ABI3BP 0.574847839298605 4.51287502066478e-07 -2.67294165600819 1.2145292807081e-35 miRNATAP -0.39552672294407 2.99375159232311e-09 NA NA NA hsa-miR-32-5p ABI3BP 1.38676603945192 2.29428299685976e-34 -2.67294165600819 1.2145292807081e-35 miRNATAP -0.445644412666975 4.34885681635208e-12 NA NA NA hsa-miR-320b ABI3BP 0.412787504747938 0.00113457276903985 -2.67294165600819 1.2145292807081e-35 miRanda -0.278628397419649 4.37185865884698e-06 NA NA NA hsa-miR-338-3p ABI3BP 0.0799903526884966 0.575137668326679 -2.67294165600819 1.2145292807081e-35 miRanda -0.19516673174149 0.000291142631772571 NA NA NA hsa-miR-455-5p ABI3BP 0.284641224662773 0.0357572339594277 -2.67294165600819 1.2145292807081e-35 miRanda -0.180598454164804 0.00146036172998842 NA NA NA hsa-miR-576-5p ABI3BP 0.0649387707567879 0.588791966096287 -2.67294165600819 1.2145292807081e-35 PITA -0.197026192348086 0.00213334970228822 NA NA NA hsa-miR-590-3p ABI3BP 1.27438512890514 1.03164723481469e-23 -2.67294165600819 1.2145292807081e-35 miRanda -0.435167057405369 8.5974663097589e-13 NA NA NA hsa-miR-590-5p ABI3BP 0.746515607868274 8.51300479640125e-09 -2.67294165600819 1.2145292807081e-35 miRanda -0.468011188047892 6.39405864938427e-16 NA NA NA hsa-miR-92a-3p ABI3BP -0.342420481092807 0.000732275969501111 -2.67294165600819 1.2145292807081e-35 miRNATAP -0.437216913594176 6.59264406680261e-09 NA NA NA hsa-miR-92b-3p ABI3BP 1.30248132773644 9.42428674470985e-25 -2.67294165600819 1.2145292807081e-35 miRNATAP -0.435869147934848 6.30278801418165e-14 NA NA NA hsa-miR-484 ACTA2 0.349444060004737 0.00154491249625173 -1.56988014142593 3.09722059033362e-34 miRNAWalker2_validate -0.258305967833468 4.1927234077091e-10 NA NA NA hsa-miR-139-5p ADAM12 -3.25846663863766 2.62018989415003e-112 1.30450214121638 3.98075183367988e-15 miRanda -0.188322089006 5.05472723158868e-08 NA NA NA hsa-miR-186-5p ADAM12 -0.426987301460247 1.04129380549315e-05 1.30450214121638 3.98075183367988e-15 mirMAP -0.247632522009764 3.28123213005703e-05 NA NA NA hsa-miR-19a-3p ADAM12 0.817507952171848 3.76285090469625e-08 1.30450214121638 3.98075183367988e-15 miRNATAP -0.224970595032771 4.6059484370303e-09 NA NA NA hsa-miR-19b-3p ADAM12 0.139124391010031 0.255658553872934 1.30450214121638 3.98075183367988e-15 miRNATAP -0.349161439609259 8.37868317945161e-14 NA NA NA hsa-miR-26a-5p ADAM12 -0.481180084102235 1.82368246174758e-10 1.30450214121638 3.98075183367988e-15 mirMAP;miRNATAP -0.373906322347109 9.41212720351037e-07 NA NA NA hsa-miR-26b-5p ADAM12 -0.331527896896866 0.000551258576575092 1.30450214121638 3.98075183367988e-15 mirMAP;miRNATAP -0.222081298741474 0.000235443298457112 NA NA NA hsa-miR-29a-3p ADAM12 -0.699539666833076 1.13935003139957e-13 1.30450214121638 3.98075183367988e-15 miRNATAP -0.386606790672911 1.38845582537111e-10 25886595 ADAM12 L is a direct target of the miR 29 and miR 200 families in breast cancer breast cancer hsa-miR-29b-3p ADAM12 0.438847962603729 6.46722433236121e-05 1.30450214121638 3.98075183367988e-15 miRNAWalker2_validate;miRTarBase;miRNATAP -0.406735608867068 4.42698571657384e-15 25886595 ADAM12 L is a direct target of the miR 29 and miR 200 families in breast cancer breast cancer hsa-miR-29c-3p ADAM12 -0.0652732378039769 0.563774115756922 1.30450214121638 3.98075183367988e-15 miRNATAP -0.399680025967661 2.76932529531384e-15 NA NA NA hsa-miR-320a ADAM12 -0.287921276129346 0.00141693637596294 1.30450214121638 3.98075183367988e-15 mirMAP -0.238668746136108 0.000207000235442325 NA NA NA hsa-miR-338-3p ADAM12 0.0799903526884966 0.575137668326679 1.30450214121638 3.98075183367988e-15 miRanda -0.284658120327581 1.3312431566143e-12 NA NA NA hsa-miR-361-5p ADAM12 -0.0996867547900457 0.095428250126326 1.30450214121638 3.98075183367988e-15 miRanda -0.539199614962361 3.64040601226611e-08 NA NA NA hsa-miR-374a-5p ADAM12 -0.239709888246804 0.00309819667153627 1.30450214121638 3.98075183367988e-15 mirMAP -0.231896097763684 0.00125130667965345 NA NA NA hsa-miR-374b-5p ADAM12 -0.466781429946153 1.17238311619116e-08 1.30450214121638 3.98075183367988e-15 mirMAP -0.216721433626076 0.00216401035370454 NA NA NA hsa-miR-16-5p ANPEP 0.46835991343556 1.91125356547776e-06 -1.77724581367248 2.49549372132156e-18 miRNAWalker2_validate -0.392215566462159 4.98200117331063e-08 NA NA NA hsa-miR-96-5p ANPEP 3.24596558166606 1.92296159041707e-98 -1.77724581367248 2.49549372132156e-18 mirMAP -0.335327151231264 1.02022529938659e-16 NA NA NA hsa-miR-335-5p APLP1 -2.61355235628987 2.6462884165886e-51 1.5236861073529 2.43885608522215e-12 miRNAWalker2_validate -0.197030082438244 1.34770900138626e-06 NA NA NA hsa-miR-107 AREG 0.678998026350662 2.56224148930538e-16 -0.778303606133199 0.00739078553830674 miRanda -0.406038762215162 0.000634360053700675 NA NA NA hsa-miR-330-5p AREG 0.626063225953928 3.42215028606779e-09 -0.778303606133199 0.00739078553830674 miRanda -0.335793060377933 0.000327824351427213 NA NA NA hsa-miR-590-3p AREG 1.27438512890514 1.03164723481469e-23 -0.778303606133199 0.00739078553830674 miRanda -0.406562840780303 3.20287409706028e-07 NA NA NA hsa-miR-139-5p BASP1 -3.25846663863766 2.62018989415003e-112 1.15434272740357 5.93241359054435e-21 miRanda -0.117754399956619 5.17887138100347e-06 NA NA NA hsa-miR-142-5p BDNF 1.16509303143593 1.96641162209073e-13 -1.60102244727579 3.13378744159785e-14 mirMAP -0.203218784089295 7.99082093515086e-06 NA NA NA hsa-miR-148a-5p BDNF 0.572692271754695 2.14306251522796e-06 -1.60102244727579 3.13378744159785e-14 mirMAP -0.397766884665729 3.21732972253681e-11 NA NA NA hsa-miR-155-5p BDNF 1.09766314984151 4.55650930885814e-15 -1.60102244727579 3.13378744159785e-14 miRNATAP -0.268404245015568 1.69880913103772e-07 NA NA NA hsa-miR-15a-5p BDNF 0.812445324157528 4.50263417099822e-20 -1.60102244727579 3.13378744159785e-14 MirTarget;miRNATAP -0.270462236614116 0.000896358870417413 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC liver cancer hsa-miR-16-5p BDNF 0.46835991343556 1.91125356547776e-06 -1.60102244727579 3.13378744159785e-14 MirTarget;miRNATAP -0.207572734514068 0.0054038108129975 NA NA NA hsa-miR-182-5p BDNF 2.36408084103818 2.60011457600281e-72 -1.60102244727579 3.13378744159785e-14 MirTarget;miRNATAP -0.234588678348713 3.99165896393269e-06 NA NA NA hsa-miR-210-3p BDNF 2.38367203491819 3.73261999106754e-22 -1.60102244727579 3.13378744159785e-14 miRNAWalker2_validate;miRTarBase -0.115495455176462 6.58638340303894e-05 NA NA NA hsa-miR-30e-5p BDNF 0.293491764699475 0.000372291967271834 -1.60102244727579 3.13378744159785e-14 miRNATAP -0.400421315846613 7.13698491153316e-06 NA NA NA hsa-miR-589-3p BDNF 0.0263457630961427 0.866577983997705 -1.60102244727579 3.13378744159785e-14 MirTarget -0.125027718317622 0.00920347953748705 NA NA NA hsa-miR-589-5p BDNF 0.367182541239722 1.67804815542873e-05 -1.60102244727579 3.13378744159785e-14 miRNATAP -0.314299850428925 0.00026517944556323 NA NA NA hsa-miR-590-3p BDNF 1.27438512890514 1.03164723481469e-23 -1.60102244727579 3.13378744159785e-14 miRanda;mirMAP;miRNATAP -0.314287602443717 7.91546458232199e-08 NA NA NA hsa-miR-7-1-3p BDNF 0.686579567507582 1.20731554448806e-07 -1.60102244727579 3.13378744159785e-14 MirTarget -0.157643440663764 0.00510952033279118 NA NA NA hsa-miR-30b-3p BGN -0.536462824497982 2.41814659272548e-05 2.33977700772477 1.83447359500135e-74 mirMAP -0.304776406507502 4.14469945454881e-16 NA NA NA hsa-miR-326 BGN -1.54449030848141 1.04703417845594e-17 2.33977700772477 1.83447359500135e-74 miRanda -0.162073604323733 4.6837854888972e-10 NA NA NA hsa-miR-486-5p BGN -3.87258704301474 1.22658629378451e-80 2.33977700772477 1.83447359500135e-74 miRanda -0.212880218996298 1.3509058714132e-24 NA NA NA hsa-miR-125a-5p BMP1 -0.635694700253268 3.6703235721638e-11 0.565301253063899 6.06878861078194e-08 mirMAP -0.19840140097214 8.29887981738214e-08 NA NA NA hsa-miR-29a-3p BMP1 -0.699539666833076 1.13935003139957e-13 0.565301253063899 6.06878861078194e-08 miRNATAP -0.143073244068128 0.000152483369514701 NA NA NA hsa-miR-29b-3p BMP1 0.438847962603729 6.46722433236121e-05 0.565301253063899 6.06878861078194e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.231090106921138 9.37208555695595e-13 NA NA NA hsa-miR-29c-3p BMP1 -0.0652732378039769 0.563774115756922 0.565301253063899 6.06878861078194e-08 miRNATAP -0.280153370406156 3.64515578191117e-19 NA NA NA hsa-miR-30b-3p BMP1 -0.536462824497982 2.41814659272548e-05 0.565301253063899 6.06878861078194e-08 miRNATAP -0.243422308899919 2.5778292746612e-18 NA NA NA hsa-miR-335-5p BMP1 -2.61355235628987 2.6462884165886e-51 0.565301253063899 6.06878861078194e-08 miRNAWalker2_validate -0.115853017604082 2.21050930979131e-09 NA NA NA hsa-miR-339-5p BMP1 -0.211548290465418 0.0685885445822389 0.565301253063899 6.06878861078194e-08 miRanda -0.105002246327012 0.000724159327297652 NA NA NA hsa-miR-491-5p BMP1 -1.04307210952796 1.14586501470398e-15 0.565301253063899 6.06878861078194e-08 PITA;miRanda -0.108587291250698 7.17365242921751e-05 NA NA NA hsa-miR-15a-5p CADM1 0.812445324157528 4.50263417099822e-20 -0.0699204971408882 0.585878770512374 miRNAWalker2_validate;miRTarBase;miRNATAP -0.199087358235994 4.24758390787005e-05 NA NA NA hsa-miR-335-3p CADM1 -1.88448538773649 2.09538234398335e-32 -0.0699204971408882 0.585878770512374 mirMAP -0.120365669484336 5.40145030404634e-06 NA NA NA hsa-miR-106b-5p CALD1 1.22477789913175 2.31787213143326e-32 -0.977982331069182 1.18727276687937e-21 miRNATAP -0.240692552519683 3.57051416918414e-13 NA NA NA hsa-miR-107 CALD1 0.678998026350662 2.56224148930538e-16 -0.977982331069182 1.18727276687937e-21 miRanda -0.370223091656363 1.27875178885176e-18 NA NA NA hsa-miR-15a-5p CALD1 0.812445324157528 4.50263417099822e-20 -0.977982331069182 1.18727276687937e-21 miRNAWalker2_validate -0.386151462594154 2.88036713071324e-23 NA NA NA hsa-miR-16-2-3p CALD1 0.286355254959005 0.0256946046884474 -0.977982331069182 1.18727276687937e-21 mirMAP -0.103503336616112 0.000240520558776444 NA NA NA hsa-miR-182-5p CALD1 2.36408084103818 2.60011457600281e-72 -0.977982331069182 1.18727276687937e-21 MirTarget -0.254724657836353 8.91506681099781e-26 NA NA NA hsa-miR-20a-5p CALD1 0.44979911120222 0.000602386964327228 -0.977982331069182 1.18727276687937e-21 miRNATAP -0.125183267446611 4.51420907918682e-06 NA NA NA hsa-miR-21-5p CALD1 2.32007501846389 3.08394781855554e-137 -0.977982331069182 1.18727276687937e-21 miRNAWalker2_validate;MirTarget -0.114490339096093 0.000456521184701928 NA NA NA hsa-miR-338-3p CALD1 0.0799903526884966 0.575137668326679 -0.977982331069182 1.18727276687937e-21 miRanda -0.181903760147575 2.8216133695753e-13 NA NA NA hsa-miR-429 CALD1 2.84108892259147 3.88520896426515e-64 -0.977982331069182 1.18727276687937e-21 miRanda -0.194144719434878 1.04456800638229e-23 NA NA NA hsa-miR-590-3p CALD1 1.27438512890514 1.03164723481469e-23 -0.977982331069182 1.18727276687937e-21 miRanda;mirMAP -0.127778257999867 8.73009627456535e-06 NA NA NA hsa-miR-93-5p CALD1 1.01788600209314 1.24312921618126e-21 -0.977982331069182 1.18727276687937e-21 miRNATAP -0.233080694316896 8.65458200221473e-13 NA NA NA hsa-let-7a-5p CALU -0.210286642041636 0.0072546234707717 0.488633290599133 5.44643104443692e-09 TargetScan -0.271232602059018 1.53903882512796e-13 NA NA NA hsa-miR-103a-3p CALU 0.610673390034345 1.63113920514646e-12 0.488633290599133 5.44643104443692e-09 miRNAWalker2_validate;MirTarget -0.259446293443169 2.1531950079575e-15 NA NA NA hsa-miR-195-5p CALU -1.47508108420708 2.20685847368258e-38 0.488633290599133 5.44643104443692e-09 MirTarget -0.227817657339994 7.24119837093103e-22 NA NA NA hsa-miR-29a-3p CALU -0.699539666833076 1.13935003139957e-13 0.488633290599133 5.44643104443692e-09 MirTarget -0.178665164609573 3.17161758958381e-09 NA NA NA hsa-miR-29c-3p CALU -0.0652732378039769 0.563774115756922 0.488633290599133 5.44643104443692e-09 MirTarget -0.382077967714068 2.11201526660035e-57 NA NA NA hsa-miR-30a-5p CALU -0.392489994825279 0.00954894667761676 0.488633290599133 5.44643104443692e-09 MirTarget -0.150083685230791 1.38674246819198e-15 NA NA NA hsa-miR-30b-5p CALU -0.46540603860146 2.4709940429591e-05 0.488633290599133 5.44643104443692e-09 MirTarget -0.160560703914744 6.27552986074823e-10 NA NA NA hsa-miR-30d-5p CALU -0.247082219011045 0.00406717930063148 0.488633290599133 5.44643104443692e-09 MirTarget -0.182501508254835 5.7020489362079e-08 NA NA NA hsa-miR-374a-5p CALU -0.239709888246804 0.00309819667153627 0.488633290599133 5.44643104443692e-09 mirMAP -0.110392576047929 0.00212344385795724 NA NA NA hsa-miR-582-5p CAP2 0.201134299470983 0.149482495292227 -0.447470554769281 0.000841231621756602 PITA;miRNATAP -0.142813508732905 1.79925275741069e-05 NA NA NA hsa-miR-590-3p CAP2 1.27438512890514 1.03164723481469e-23 -0.447470554769281 0.000841231621756602 PITA;miRanda;mirMAP -0.142605768123729 0.000108297349258733 NA NA NA hsa-let-7b-5p CAPG -0.54215483448257 7.21347617597858e-08 1.28776877951361 5.17086999721969e-32 miRNAWalker2_validate -0.23764873783212 5.15452068743417e-10 NA NA NA hsa-miR-139-5p CAPG -3.25846663863766 2.62018989415003e-112 1.28776877951361 5.17086999721969e-32 miRanda -0.225502427289996 4.59130102006183e-23 NA NA NA hsa-miR-340-5p CD44 1.0857159627596 4.94471062546756e-24 0.0630593342056205 0.572406231315822 mirMAP -0.115345283763511 0.000887927550727641 NA NA NA hsa-miR-141-3p CD59 2.99777540204168 1.26370498493024e-78 -0.855467054419464 8.25618549169397e-22 mirMAP -0.10076056346922 1.11975519170288e-08 NA NA NA hsa-miR-182-5p CD59 2.36408084103818 2.60011457600281e-72 -0.855467054419464 8.25618549169397e-22 MirTarget -0.170054062793489 2.1252119909682e-15 NA NA NA hsa-miR-126-5p CDH11 -1.27745588751177 2.96000918537631e-30 1.20920163585215 4.61017150120051e-17 mirMAP -0.180242821274353 3.29443118143086e-05 NA NA NA hsa-miR-139-5p CDH11 -3.25846663863766 2.62018989415003e-112 1.20920163585215 4.61017150120051e-17 miRanda -0.199282352616151 2.70736068996111e-11 NA NA NA hsa-miR-144-5p CDH11 -2.75914786146772 1.55794225315972e-50 1.20920163585215 4.61017150120051e-17 mirMAP -0.194647789101792 1.13740168566596e-14 NA NA NA hsa-miR-16-2-3p CDH11 0.286355254959005 0.0256946046884474 1.20920163585215 4.61017150120051e-17 mirMAP -0.257052671390965 4.95521268222169e-11 NA NA NA hsa-miR-320a CDH11 -0.287921276129346 0.00141693637596294 1.20920163585215 4.61017150120051e-17 miRanda -0.234406238127129 2.71248095805276e-05 NA NA NA hsa-miR-320b CDH11 0.412787504747938 0.00113457276903985 1.20920163585215 4.61017150120051e-17 miRanda -0.110661374271191 0.00553783126894088 NA NA NA hsa-miR-335-5p CDH11 -2.61355235628987 2.6462884165886e-51 1.20920163585215 4.61017150120051e-17 miRNAWalker2_validate -0.14988313233567 3.20971284994355e-08 NA NA NA hsa-miR-500a-5p CDH11 0.209805801129289 0.119177819862398 1.20920163585215 4.61017150120051e-17 mirMAP -0.233184356058699 5.74851030987989e-10 NA NA NA hsa-miR-576-5p CDH11 0.0649387707567879 0.588791966096287 1.20920163585215 4.61017150120051e-17 PITA;mirMAP;miRNATAP -0.139410459584452 0.000903101010833768 NA NA NA hsa-miR-590-3p CDH11 1.27438512890514 1.03164723481469e-23 1.20920163585215 4.61017150120051e-17 miRanda;mirMAP -0.125373718236018 0.00188749376705719 NA NA NA hsa-miR-139-5p CDH2 -3.25846663863766 2.62018989415003e-112 1.79603953433003 3.53117483537472e-18 miRanda -0.439807325574357 1.92749263453179e-25 NA NA NA hsa-miR-218-5p CDH2 -1.02621788318234 2.9221925445771e-23 1.79603953433003 3.53117483537472e-18 miRNATAP -0.18896070803014 0.00572326307817043 24705471 ADAM9 up regulates N cadherin via miR 218 suppression in lung adenocarcinoma cells; Luciferase assays and western blot analysis showed that CDH2 is a target gene of miR-218 lung cancer hsa-miR-26a-5p CDH2 -0.481180084102235 1.82368246174758e-10 1.79603953433003 3.53117483537472e-18 miRNATAP -0.661499990013135 2.65979621763783e-12 NA NA NA hsa-miR-26b-5p CDH2 -0.331527896896866 0.000551258576575092 1.79603953433003 3.53117483537472e-18 miRNATAP -0.2730223690161 0.000296536534724819 NA NA NA hsa-miR-30a-5p CDH2 -0.392489994825279 0.00954894667761676 1.79603953433003 3.53117483537472e-18 miRNAWalker2_validate -0.289836935187057 9.17048806087909e-10 21633953 Consistent with this microRNA-30a expression was found inversely proportional to the invasive potential of various NSCLC cell lines correlating positively with E-cadherin epithelial marker and negatively with N-cadherin mesenchymal marker expression lung squamous cell cancer hsa-miR-320a CDH2 -0.287921276129346 0.00141693637596294 1.79603953433003 3.53117483537472e-18 MirTarget;PITA;miRanda;miRNATAP -0.34549902728144 1.66904576641267e-05 NA NA NA hsa-miR-361-3p CDH2 -0.0370446538644886 0.624902392829872 1.79603953433003 3.53117483537472e-18 miRNATAP -0.354994220142266 0.000228740640604513 NA NA NA hsa-miR-361-5p CDH2 -0.0996867547900457 0.095428250126326 1.79603953433003 3.53117483537472e-18 miRanda -0.418726277153716 0.000663046735636235 NA NA NA hsa-miR-452-5p CDH2 -2.48486455572568 1.24430987974325e-33 1.79603953433003 3.53117483537472e-18 miRNATAP -0.138218625809158 3.98822584108841e-05 NA NA NA hsa-miR-155-5p CDH6 1.09766314984151 4.55650930885814e-15 -0.970669875320658 5.55111886434944e-15 miRNAWalker2_validate -0.210787613858864 2.34596348831422e-12 NA NA NA hsa-miR-15b-3p CDH6 1.12898579025388 1.18050912917317e-14 -0.970669875320658 5.55111886434944e-15 mirMAP -0.175697364734614 1.18611226960217e-09 NA NA NA hsa-miR-200a-5p CDH6 2.58844508672328 1.79650654234569e-56 -0.970669875320658 5.55111886434944e-15 mirMAP -0.196448071819219 5.56177809763226e-16 NA NA NA hsa-miR-200b-3p CDH6 2.11744072703209 1.66710572104191e-43 -0.970669875320658 5.55111886434944e-15 TargetScan -0.264470815531992 3.37380877825487e-24 NA NA NA hsa-miR-20a-3p CDH6 -0.218902047543766 0.179868363625547 -0.970669875320658 5.55111886434944e-15 mirMAP -0.120535051504674 5.53075502105498e-06 NA NA NA hsa-miR-29a-5p CDH6 0.334183773952055 0.00445137265870197 -0.970669875320658 5.55111886434944e-15 mirMAP -0.159270008736301 1.56284325578039e-05 NA NA NA hsa-miR-330-3p CDH6 0.432728362037032 0.00041335506960812 -0.970669875320658 5.55111886434944e-15 miRNATAP -0.13305155998589 0.000196765105793084 NA NA NA hsa-miR-339-5p CDH6 -0.211548290465418 0.0685885445822389 -0.970669875320658 5.55111886434944e-15 miRanda -0.105554114518654 0.0047340293424813 NA NA NA hsa-miR-340-5p CDH6 1.0857159627596 4.94471062546756e-24 -0.970669875320658 5.55111886434944e-15 mirMAP -0.254756720772425 5.97174725251082e-11 NA NA NA hsa-miR-3913-5p CDH6 0.71890413546147 2.61153227160465e-13 -0.970669875320658 5.55111886434944e-15 mirMAP -0.163310124220051 0.000180229323875004 NA NA NA hsa-miR-429 CDH6 2.84108892259147 3.88520896426515e-64 -0.970669875320658 5.55111886434944e-15 miRanda;miRNATAP -0.248000893049189 1.11094096699313e-26 NA NA NA hsa-miR-501-3p CDH6 0.0448022813406874 0.711710441403614 -0.970669875320658 5.55111886434944e-15 MirTarget -0.150860360221257 2.4390215583023e-05 NA NA NA hsa-miR-502-3p CDH6 0.11461741546458 0.276553832470138 -0.970669875320658 5.55111886434944e-15 MirTarget -0.200976167431303 1.0186627127617e-06 NA NA NA hsa-miR-576-5p CDH6 0.0649387707567879 0.588791966096287 -0.970669875320658 5.55111886434944e-15 PITA;mirMAP -0.136611508336533 0.000153483828736059 NA NA NA hsa-miR-582-5p CDH6 0.201134299470983 0.149482495292227 -0.970669875320658 5.55111886434944e-15 mirMAP -0.128816094314123 3.9399785572105e-05 NA NA NA hsa-miR-590-3p CDH6 1.27438512890514 1.03164723481469e-23 -0.970669875320658 5.55111886434944e-15 miRanda -0.245380138207288 8.16385965133356e-13 NA NA NA hsa-let-7a-5p COL11A1 -0.210286642041636 0.0072546234707717 5.98557038029313 1.10741703125517e-74 TargetScan -0.701024618938809 9.34857888922153e-06 NA NA NA hsa-miR-126-5p COL11A1 -1.27745588751177 2.96000918537631e-30 5.98557038029313 1.10741703125517e-74 MirTarget;mirMAP -1.03277999455585 2.70282238590085e-23 NA NA NA hsa-miR-139-5p COL11A1 -3.25846663863766 2.62018989415003e-112 5.98557038029313 1.10741703125517e-74 miRanda -1.31747531356369 1.32600752122946e-87 NA NA NA hsa-miR-143-3p COL11A1 -1.23248181631499 4.74160976678504e-28 5.98557038029313 1.10741703125517e-74 MirTarget -0.659991155080745 4.02698262970475e-10 NA NA NA hsa-miR-195-3p COL11A1 -1.49582726452416 6.53261924105147e-40 5.98557038029313 1.10741703125517e-74 MirTarget -0.976344843857275 7.00601834796277e-22 NA NA NA hsa-miR-217 COL11A1 -0.616728851115349 8.64977119332241e-05 5.98557038029313 1.10741703125517e-74 miRanda -0.337863160384421 1.50734900536863e-05 NA NA NA hsa-miR-25-3p COL11A1 -0.00546790775985073 0.944061771389468 5.98557038029313 1.10741703125517e-74 MirTarget -0.847680937343123 9.62415000938307e-08 NA NA NA hsa-miR-26a-5p COL11A1 -0.481180084102235 1.82368246174758e-10 5.98557038029313 1.10741703125517e-74 miRNATAP -1.53480926538678 5.41371496070299e-22 NA NA NA hsa-miR-26b-5p COL11A1 -0.331527896896866 0.000551258576575092 5.98557038029313 1.10741703125517e-74 miRNATAP -0.505838237810205 8.35317058219654e-05 NA NA NA hsa-miR-29a-3p COL11A1 -0.699539666833076 1.13935003139957e-13 5.98557038029313 1.10741703125517e-74 MirTarget;miRNATAP -1.18901217731726 5.89312781020075e-21 NA NA NA hsa-miR-29c-3p COL11A1 -0.0652732378039769 0.563774115756922 5.98557038029313 1.10741703125517e-74 MirTarget;miRNATAP -0.777296203521873 6.49420765982035e-13 NA NA NA hsa-miR-335-3p COL11A1 -1.88448538773649 2.09538234398335e-32 5.98557038029313 1.10741703125517e-74 mirMAP -0.754721613563655 1.9500617458659e-25 NA NA NA hsa-miR-335-5p COL11A1 -2.61355235628987 2.6462884165886e-51 5.98557038029313 1.10741703125517e-74 miRNAWalker2_validate -0.781512756031571 4.22709692413003e-34 NA NA NA hsa-miR-361-5p COL11A1 -0.0996867547900457 0.095428250126326 5.98557038029313 1.10741703125517e-74 miRanda;miRNATAP -1.24312260976817 2.38395594263168e-09 NA NA NA hsa-miR-374a-5p COL11A1 -0.239709888246804 0.00309819667153627 5.98557038029313 1.10741703125517e-74 mirMAP -1.07008309214987 1.53537791654329e-12 NA NA NA hsa-miR-374b-5p COL11A1 -0.466781429946153 1.17238311619116e-08 5.98557038029313 1.10741703125517e-74 mirMAP -0.856296613050462 1.02278639426801e-08 NA NA NA hsa-miR-381-3p COL11A1 -1.28028930293369 1.61402949866141e-23 5.98557038029313 1.10741703125517e-74 MirTarget -0.294525533481499 0.00168730541845439 NA NA NA hsa-miR-92a-3p COL11A1 -0.342420481092807 0.000732275969501111 5.98557038029313 1.10741703125517e-74 MirTarget -0.443464226361667 0.000268693761033505 NA NA NA hsa-miR-107 COL12A1 0.678998026350662 2.56224148930538e-16 1.00034582035453 8.06545185719229e-10 miRanda -0.255892829631528 0.000137866258327884 NA NA NA hsa-miR-126-5p COL12A1 -1.27745588751177 2.96000918537631e-30 1.00034582035453 8.06545185719229e-10 mirMAP -0.214141203094137 1.04579627236741e-05 NA NA NA hsa-miR-15a-5p COL12A1 0.812445324157528 4.50263417099822e-20 1.00034582035453 8.06545185719229e-10 MirTarget;miRNATAP -0.321048560409426 2.47259045982563e-07 NA NA NA hsa-miR-15b-5p COL12A1 0.788659356634696 1.13678211092534e-11 1.00034582035453 8.06545185719229e-10 MirTarget;miRNATAP -0.129550256753951 0.00701979293356751 NA NA NA hsa-miR-17-3p COL12A1 0.721439431208839 7.95900548819742e-10 1.00034582035453 8.06545185719229e-10 MirTarget;miRNATAP -0.448946347770228 4.55929407426649e-22 NA NA NA hsa-miR-195-5p COL12A1 -1.47508108420708 2.20685847368258e-38 1.00034582035453 8.06545185719229e-10 MirTarget;miRNATAP -0.233742924507979 6.95829850827218e-07 NA NA NA hsa-miR-25-3p COL12A1 -0.00546790775985073 0.944061771389468 1.00034582035453 8.06545185719229e-10 miRNATAP -0.61901520926357 5.68987477605186e-18 NA NA NA hsa-miR-26a-5p COL12A1 -0.481180084102235 1.82368246174758e-10 1.00034582035453 8.06545185719229e-10 miRNATAP -0.531566996253368 5.2331807974705e-13 NA NA NA hsa-miR-26b-5p COL12A1 -0.331527896896866 0.000551258576575092 1.00034582035453 8.06545185719229e-10 miRNATAP -0.194290604239199 0.000960350062701581 NA NA NA hsa-miR-30a-5p COL12A1 -0.392489994825279 0.00954894667761676 1.00034582035453 8.06545185719229e-10 mirMAP -0.181500044095451 9.54570117115514e-07 NA NA NA hsa-miR-30b-5p COL12A1 -0.46540603860146 2.4709940429591e-05 1.00034582035453 8.06545185719229e-10 mirMAP -0.417337463007329 8.33708436859084e-17 NA NA NA hsa-miR-30c-5p COL12A1 -0.393222674580066 8.06961465717306e-05 1.00034582035453 8.06545185719229e-10 mirMAP -0.383163818609591 7.32388615995342e-12 NA NA NA hsa-miR-30d-3p COL12A1 0.264544633563642 0.00755023189129747 1.00034582035453 8.06545185719229e-10 miRNATAP -0.402115745875875 1.05743650053629e-12 NA NA NA hsa-miR-30d-5p COL12A1 -0.247082219011045 0.00406717930063148 1.00034582035453 8.06545185719229e-10 mirMAP -0.573271797102623 6.65614713852213e-19 NA NA NA hsa-miR-32-5p COL12A1 1.38676603945192 2.29428299685976e-34 1.00034582035453 8.06545185719229e-10 miRNATAP -0.146748418938776 0.00211393607167005 NA NA NA hsa-miR-335-3p COL12A1 -1.88448538773649 2.09538234398335e-32 1.00034582035453 8.06545185719229e-10 mirMAP -0.17304466583573 3.31684589554063e-07 NA NA NA hsa-miR-338-3p COL12A1 0.0799903526884966 0.575137668326679 1.00034582035453 8.06545185719229e-10 miRanda -0.211764051684815 7.2790651013892e-08 NA NA NA hsa-miR-502-3p COL12A1 0.11461741546458 0.276553832470138 1.00034582035453 8.06545185719229e-10 PITA -0.32602876767708 9.74257780377449e-10 NA NA NA hsa-miR-532-5p COL12A1 0.0386976222860582 0.682018574136515 1.00034582035453 8.06545185719229e-10 PITA -0.338051497147086 1.44117366176629e-08 NA NA NA hsa-miR-590-3p COL12A1 1.27438512890514 1.03164723481469e-23 1.00034582035453 8.06545185719229e-10 miRanda -0.157807079584516 0.000474102875289977 NA NA NA hsa-miR-590-5p COL12A1 0.746515607868274 8.51300479640125e-09 1.00034582035453 8.06545185719229e-10 PITA;miRanda -0.17975019427532 3.01694206751363e-05 NA NA NA hsa-miR-92a-3p COL12A1 -0.342420481092807 0.000732275969501111 1.00034582035453 8.06545185719229e-10 miRNATAP -0.440941139727372 8.38437874798664e-16 NA NA NA hsa-miR-29b-3p COL16A1 0.438847962603729 6.46722433236121e-05 0.0334366008721423 0.806791242612889 miRNATAP -0.382960834796143 3.72208491226835e-20 NA NA NA hsa-miR-491-5p COL16A1 -1.04307210952796 1.14586501470398e-15 0.0334366008721423 0.806791242612889 miRanda -0.225987650414401 1.48180234811874e-10 NA NA NA hsa-miR-590-3p COL16A1 1.27438512890514 1.03164723481469e-23 0.0334366008721423 0.806791242612889 miRanda -0.333324855706173 1.12212367836949e-19 NA NA NA hsa-let-7a-5p COL1A1 -0.210286642041636 0.0072546234707717 2.5651762209113 9.3730343879076e-47 TargetScan;miRNATAP -0.24089218391089 0.00393524214991794 NA NA NA hsa-let-7b-5p COL1A1 -0.54215483448257 7.21347617597858e-08 2.5651762209113 9.3730343879076e-47 miRNATAP -0.208318456681387 0.00118621429715631 NA NA NA hsa-let-7g-5p COL1A1 0.0200025784917734 0.791635298815256 2.5651762209113 9.3730343879076e-47 miRNATAP -0.502387292694151 5.2158427786542e-09 NA NA NA hsa-miR-126-5p COL1A1 -1.27745588751177 2.96000918537631e-30 2.5651762209113 9.3730343879076e-47 miRNATAP -0.431075814120194 6.33610324209054e-15 NA NA NA hsa-miR-17-5p COL1A1 0.599531757298529 1.07318660415906e-05 2.5651762209113 9.3730343879076e-47 mirMAP -0.279131452817333 3.18067245709467e-09 NA NA NA hsa-miR-193a-5p COL1A1 -1.1508321886378 7.11949564429669e-37 2.5651762209113 9.3730343879076e-47 PITA;TargetScan;miRNATAP -0.419754083355121 7.32652492145808e-10 NA NA NA hsa-miR-20a-5p COL1A1 0.44979911120222 0.000602386964327228 2.5651762209113 9.3730343879076e-47 mirMAP -0.264687400603912 7.34043720394447e-08 NA NA NA hsa-miR-29a-3p COL1A1 -0.699539666833076 1.13935003139957e-13 2.5651762209113 9.3730343879076e-47 miRNATAP -0.505920263846829 5.4026826839022e-14 NA NA NA hsa-miR-29b-3p COL1A1 0.438847962603729 6.46722433236121e-05 2.5651762209113 9.3730343879076e-47 miRNAWalker2_validate;miRTarBase;miRNATAP -0.42483491870975 3.19558825282899e-13 NA NA NA hsa-miR-29c-3p COL1A1 -0.0652732378039769 0.563774115756922 2.5651762209113 9.3730343879076e-47 miRNAWalker2_validate;miRTarBase;miRNATAP -0.308413017460321 7.31731652067127e-08 NA NA NA hsa-miR-30a-3p COL1A1 -1.08956435286856 1.10750674569595e-12 2.5651762209113 9.3730343879076e-47 mirMAP -0.293364132995892 1.26433028895325e-12 NA NA NA hsa-miR-30b-3p COL1A1 -0.536462824497982 2.41814659272548e-05 2.5651762209113 9.3730343879076e-47 miRNATAP -0.444357683038922 9.1689823110698e-19 NA NA NA hsa-miR-30d-3p COL1A1 0.264544633563642 0.00755023189129747 2.5651762209113 9.3730343879076e-47 mirMAP -0.429158337602994 4.53272123771336e-11 NA NA NA hsa-miR-30e-3p COL1A1 -0.708952170420973 1.05866470714978e-22 2.5651762209113 9.3730343879076e-47 mirMAP -0.766163072983284 8.35863907266093e-19 NA NA NA hsa-miR-338-3p COL1A1 0.0799903526884966 0.575137668326679 2.5651762209113 9.3730343879076e-47 miRanda;miRNATAP -0.207676895625599 4.80091970867201e-06 NA NA NA hsa-miR-361-3p COL1A1 -0.0370446538644886 0.624902392829872 2.5651762209113 9.3730343879076e-47 PITA -0.464593125962225 6.76797418412615e-08 NA NA NA hsa-miR-532-3p COL1A1 -0.395473145042459 0.00686714288452761 2.5651762209113 9.3730343879076e-47 PITA;miRNATAP -0.295814858390006 1.57092989055696e-11 NA NA NA hsa-let-7a-3p COL1A2 0.466622567891891 3.70886257943079e-07 1.52331001708955 5.43111193537147e-20 MirTarget -0.190581165353783 0.00270286404978591 NA NA NA hsa-let-7a-5p COL1A2 -0.210286642041636 0.0072546234707717 1.52331001708955 5.43111193537147e-20 MirTarget;TargetScan;miRNATAP -0.194876554818876 0.00952052671105555 NA NA NA hsa-let-7g-5p COL1A2 0.0200025784917734 0.791635298815256 1.52331001708955 5.43111193537147e-20 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.461558685623361 2.37786040489822e-09 NA NA NA hsa-miR-125a-5p COL1A2 -0.635694700253268 3.6703235721638e-11 1.52331001708955 5.43111193537147e-20 miRanda -0.21480066787771 0.0003657222089883 NA NA NA hsa-miR-19a-3p COL1A2 0.817507952171848 3.76285090469625e-08 1.52331001708955 5.43111193537147e-20 MirTarget -0.274114501964427 1.11751402004845e-12 NA NA NA hsa-miR-19b-3p COL1A2 0.139124391010031 0.255658553872934 1.52331001708955 5.43111193537147e-20 MirTarget -0.454699809629064 1.84023698280234e-22 NA NA NA hsa-miR-25-3p COL1A2 -0.00546790775985073 0.944061771389468 1.52331001708955 5.43111193537147e-20 MirTarget;miRNATAP -0.55199742436697 1.4211368225352e-13 NA NA NA hsa-miR-26a-5p COL1A2 -0.481180084102235 1.82368246174758e-10 1.52331001708955 5.43111193537147e-20 MirTarget;miRNATAP -0.442417015562675 7.96979615182122e-09 NA NA NA hsa-miR-26b-5p COL1A2 -0.331527896896866 0.000551258576575092 1.52331001708955 5.43111193537147e-20 MirTarget;miRNATAP -0.291841349110864 1.54077222441719e-06 NA NA NA hsa-miR-29a-3p COL1A2 -0.699539666833076 1.13935003139957e-13 1.52331001708955 5.43111193537147e-20 miRNATAP -0.454797163293173 5.49456065194944e-14 NA NA NA hsa-miR-29b-3p COL1A2 0.438847962603729 6.46722433236121e-05 1.52331001708955 5.43111193537147e-20 miRNATAP -0.460605295650497 8.76503901098457e-19 NA NA NA hsa-miR-29c-3p COL1A2 -0.0652732378039769 0.563774115756922 1.52331001708955 5.43111193537147e-20 miRNAWalker2_validate;miRTarBase;miRNATAP -0.366812628404496 7.65487887214513e-13 NA NA NA hsa-miR-30a-3p COL1A2 -1.08956435286856 1.10750674569595e-12 1.52331001708955 5.43111193537147e-20 MirTarget -0.196375843318247 1.53150260349314e-07 NA NA NA hsa-miR-30d-3p COL1A2 0.264544633563642 0.00755023189129747 1.52331001708955 5.43111193537147e-20 MirTarget -0.449068692307375 1.36798508181843e-14 NA NA NA hsa-miR-30e-3p COL1A2 -0.708952170420973 1.05866470714978e-22 1.52331001708955 5.43111193537147e-20 MirTarget -0.437169418077207 3.00568168055859e-08 NA NA NA hsa-miR-500a-5p COL1A2 0.209805801129289 0.119177819862398 1.52331001708955 5.43111193537147e-20 miRNATAP -0.164084171128344 0.000189697270220366 NA NA NA hsa-miR-590-3p COL1A2 1.27438512890514 1.03164723481469e-23 1.52331001708955 5.43111193537147e-20 miRanda -0.197917414728781 2.24242453532176e-05 NA NA NA hsa-miR-7-1-3p COL1A2 0.686579567507582 1.20731554448806e-07 1.52331001708955 5.43111193537147e-20 mirMAP -0.217497538560182 1.04875229508942e-06 NA NA NA hsa-miR-92a-3p COL1A2 -0.342420481092807 0.000732275969501111 1.52331001708955 5.43111193537147e-20 MirTarget;miRNATAP -0.548144739035342 1.92986468080947e-22 NA NA NA hsa-let-7g-5p COL3A1 0.0200025784917734 0.791635298815256 1.50470077229731 1.9069386527602e-18 MirTarget;miRNATAP -0.416201550739987 1.85258594096644e-07 NA NA NA hsa-miR-141-5p COL3A1 2.38411349683216 4.56310582620282e-58 1.50470077229731 1.9069386527602e-18 MirTarget -0.108970969526337 0.00383111381765932 NA NA NA hsa-miR-16-2-3p COL3A1 0.286355254959005 0.0256946046884474 1.50470077229731 1.9069386527602e-18 MirTarget -0.297124601724546 2.10453617635289e-10 NA NA NA hsa-miR-186-5p COL3A1 -0.426987301460247 1.04129380549315e-05 1.50470077229731 1.9069386527602e-18 miRNATAP -0.449204856631619 2.27441305975513e-13 NA NA NA hsa-miR-28-5p COL3A1 -0.14267073663385 0.0497619246260571 1.50470077229731 1.9069386527602e-18 miRanda -0.217177944731906 0.00939470887863092 NA NA NA hsa-miR-29a-3p COL3A1 -0.699539666833076 1.13935003139957e-13 1.50470077229731 1.9069386527602e-18 MirTarget;miRNATAP -0.462412768241059 1.17071258313939e-13 NA NA NA hsa-miR-29b-3p COL3A1 0.438847962603729 6.46722433236121e-05 1.50470077229731 1.9069386527602e-18 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.500579179803235 7.69130347139435e-21 NA NA NA hsa-miR-29c-3p COL3A1 -0.0652732378039769 0.563774115756922 1.50470077229731 1.9069386527602e-18 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.387713636052554 1.81886620410162e-13 NA NA NA hsa-miR-335-3p COL3A1 -1.88448538773649 2.09538234398335e-32 1.50470077229731 1.9069386527602e-18 mirMAP -0.135234245228995 0.000194404748529401 NA NA NA hsa-miR-335-5p COL3A1 -2.61355235628987 2.6462884165886e-51 1.50470077229731 1.9069386527602e-18 miRNAWalker2_validate -0.177478192997637 4.26024104803443e-08 NA NA NA hsa-miR-590-3p COL3A1 1.27438512890514 1.03164723481469e-23 1.50470077229731 1.9069386527602e-18 miRanda;mirMAP -0.200218931848023 3.13908325347797e-05 NA NA NA hsa-miR-590-5p COL3A1 0.746515607868274 8.51300479640125e-09 1.50470077229731 1.9069386527602e-18 miRanda -0.255885461547733 2.26377018805921e-08 NA NA NA hsa-miR-98-5p COL3A1 0.656336869298973 9.03113188590466e-15 1.50470077229731 1.9069386527602e-18 MirTarget -0.189620962837885 0.00704575109849677 NA NA NA hsa-miR-29a-3p COL4A1 -0.699539666833076 1.13935003139957e-13 -0.0605089402704468 0.561130598229782 miRNAWalker2_validate;miRTarBase;miRNATAP -0.171325582149256 4.35526768853979e-06 NA NA NA hsa-miR-29b-3p COL4A1 0.438847962603729 6.46722433236121e-05 -0.0605089402704468 0.561130598229782 miRNAWalker2_validate;miRTarBase;miRNATAP -0.109543469213696 0.000720046923468798 NA NA NA hsa-miR-29c-3p COL4A1 -0.0652732378039769 0.563774115756922 -0.0605089402704468 0.561130598229782 miRNAWalker2_validate;miRTarBase;miRNATAP -0.187629765989983 2.23164625787479e-09 NA NA NA hsa-miR-320a COL4A1 -0.287921276129346 0.00141693637596294 -0.0605089402704468 0.561130598229782 miRanda -0.125074040546733 0.00159999785396685 NA NA NA hsa-miR-429 COL4A1 2.84108892259147 3.88520896426515e-64 -0.0605089402704468 0.561130598229782 miRanda;miRNATAP -0.117661971659563 1.69676712956939e-09 NA NA NA hsa-miR-1266-5p COL4A2 0.413134124142464 0.00276117940829758 -0.27545094339531 0.00549451640901307 MirTarget -0.105238465598966 1.87945370415893e-05 NA NA NA hsa-miR-29b-3p COL4A2 0.438847962603729 6.46722433236121e-05 -0.27545094339531 0.00549451640901307 miRTarBase;MirTarget;miRNATAP -0.135282087031871 1.16484172805038e-05 NA NA NA hsa-miR-29c-3p COL4A2 -0.0652732378039769 0.563774115756922 -0.27545094339531 0.00549451640901307 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.147928470005093 8.61297436940001e-07 NA NA NA hsa-miR-25-3p COL5A1 -0.00546790775985073 0.944061771389468 1.93353253039501 6.64983059111397e-36 miRNATAP -0.452237348260802 2.02057693113336e-10 NA NA NA hsa-miR-26a-5p COL5A1 -0.481180084102235 1.82368246174758e-10 1.93353253039501 6.64983059111397e-36 miRNATAP -0.487115134937417 1.82151484491848e-11 NA NA NA hsa-miR-26b-5p COL5A1 -0.331527896896866 0.000551258576575092 1.93353253039501 6.64983059111397e-36 miRNAWalker2_validate;miRNATAP -0.299729477764447 1.89335629129481e-07 NA NA NA hsa-miR-29a-3p COL5A1 -0.699539666833076 1.13935003139957e-13 1.93353253039501 6.64983059111397e-36 MirTarget;miRNATAP -0.473223587804176 1.26009752619713e-16 NA NA NA hsa-miR-29b-3p COL5A1 0.438847962603729 6.46722433236121e-05 1.93353253039501 6.64983059111397e-36 MirTarget;miRNATAP -0.385223753514569 8.38589352524993e-15 NA NA NA hsa-miR-29c-3p COL5A1 -0.0652732378039769 0.563774115756922 1.93353253039501 6.64983059111397e-36 MirTarget;miRNATAP -0.348870497893117 6.63721556904961e-13 NA NA NA hsa-miR-3653-3p COL5A1 -0.606718869742561 9.09775440646102e-05 1.93353253039501 6.64983059111397e-36 MirTarget -0.170353449915639 1.60177426983148e-06 NA NA NA hsa-miR-7-1-3p COL5A1 0.686579567507582 1.20731554448806e-07 1.93353253039501 6.64983059111397e-36 mirMAP -0.190464125686282 6.71750766647841e-06 NA NA NA hsa-miR-744-5p COL5A1 0.114590984077262 0.312916425462546 1.93353253039501 6.64983059111397e-36 miRNAWalker2_validate -0.238246939051442 1.0092689276689e-06 NA NA NA hsa-miR-92a-3p COL5A1 -0.342420481092807 0.000732275969501111 1.93353253039501 6.64983059111397e-36 miRNATAP -0.439667012188352 3.00438310989311e-16 NA NA NA hsa-let-7a-5p COL5A2 -0.210286642041636 0.0072546234707717 1.6351443104017 5.84941071703082e-26 MirTarget;TargetScan;miRNATAP -0.218147801585752 0.00199986778072305 NA NA NA hsa-let-7g-5p COL5A2 0.0200025784917734 0.791635298815256 1.6351443104017 5.84941071703082e-26 MirTarget;miRNATAP -0.350438952141805 1.55528132256469e-06 NA NA NA hsa-miR-126-5p COL5A2 -1.27745588751177 2.96000918537631e-30 1.6351443104017 5.84941071703082e-26 mirMAP -0.24915913277234 1.28820831948867e-07 NA NA NA hsa-miR-148a-5p COL5A2 0.572692271754695 2.14306251522796e-06 1.6351443104017 5.84941071703082e-26 MirTarget -0.122397800621009 0.00686837710197163 NA NA NA hsa-miR-16-2-3p COL5A2 0.286355254959005 0.0256946046884474 1.6351443104017 5.84941071703082e-26 MirTarget;mirMAP -0.21252882706888 7.18393595381461e-07 NA NA NA hsa-miR-195-3p COL5A2 -1.49582726452416 6.53261924105147e-40 1.6351443104017 5.84941071703082e-26 MirTarget;mirMAP -0.19192303145574 3.25595029903206e-05 NA NA NA hsa-miR-29a-3p COL5A2 -0.699539666833076 1.13935003139957e-13 1.6351443104017 5.84941071703082e-26 MirTarget;miRNATAP -0.504971843422852 3.78146764873413e-19 NA NA NA hsa-miR-29b-3p COL5A2 0.438847962603729 6.46722433236121e-05 1.6351443104017 5.84941071703082e-26 MirTarget;miRNATAP -0.401791006682411 2.71091287362831e-16 NA NA NA hsa-miR-29c-3p COL5A2 -0.0652732378039769 0.563774115756922 1.6351443104017 5.84941071703082e-26 MirTarget;miRNATAP -0.400307071269254 5.93933599742525e-17 NA NA NA hsa-miR-30a-3p COL5A2 -1.08956435286856 1.10750674569595e-12 1.6351443104017 5.84941071703082e-26 mirMAP -0.19595316145604 2.43834801419701e-08 NA NA NA hsa-miR-30e-3p COL5A2 -0.708952170420973 1.05866470714978e-22 1.6351443104017 5.84941071703082e-26 mirMAP -0.371672543516349 5.6355546924336e-07 NA NA NA hsa-miR-335-3p COL5A2 -1.88448538773649 2.09538234398335e-32 1.6351443104017 5.84941071703082e-26 MirTarget -0.15219527035695 4.1306213506414e-06 NA NA NA hsa-miR-335-5p COL5A2 -2.61355235628987 2.6462884165886e-51 1.6351443104017 5.84941071703082e-26 miRNATAP -0.189745531336072 1.18936540997693e-10 NA NA NA hsa-miR-455-5p COL5A2 0.284641224662773 0.0357572339594277 1.6351443104017 5.84941071703082e-26 miRanda -0.107100787447089 0.00828741792900282 NA NA NA hsa-miR-590-3p COL5A2 1.27438512890514 1.03164723481469e-23 1.6351443104017 5.84941071703082e-26 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.117189603810622 0.00777240026785112 NA NA NA hsa-miR-29a-3p COL5A3 -0.699539666833076 1.13935003139957e-13 0.260939522601073 0.0725025833072133 MirTarget;miRNATAP -0.327474299993675 2.63968464770582e-10 NA NA NA hsa-miR-29b-3p COL5A3 0.438847962603729 6.46722433236121e-05 0.260939522601073 0.0725025833072133 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.34812428520781 6.0002065015112e-15 NA NA NA hsa-miR-29c-3p COL5A3 -0.0652732378039769 0.563774115756922 0.260939522601073 0.0725025833072133 MirTarget;miRNATAP -0.248637486949201 1.47069067292906e-08 NA NA NA hsa-miR-330-5p COL5A3 0.626063225953928 3.42215028606779e-09 0.260939522601073 0.0725025833072133 miRanda -0.219998747483673 2.28022502039993e-06 NA NA NA hsa-miR-342-3p COL5A3 1.21944481975657 6.81914373001202e-19 0.260939522601073 0.0725025833072133 miRanda -0.161541041993619 4.92947746680876e-06 NA NA NA hsa-miR-429 COL5A3 2.84108892259147 3.88520896426515e-64 0.260939522601073 0.0725025833072133 miRanda -0.143378228864796 1.60527154004706e-07 NA NA NA hsa-miR-625-5p COL5A3 0.728939236913178 5.97591217674307e-08 0.260939522601073 0.0725025833072133 mirMAP -0.150732016408126 6.98102666318634e-05 NA NA NA hsa-miR-29a-3p COL6A3 -0.699539666833076 1.13935003139957e-13 0.634653480531805 2.31261246968383e-05 MirTarget;miRNATAP -0.330831999684707 7.53633825609695e-10 NA NA NA hsa-miR-29b-3p COL6A3 0.438847962603729 6.46722433236121e-05 0.634653480531805 2.31261246968383e-05 MirTarget;miRNATAP -0.457250270399693 1.49496395063949e-23 NA NA NA hsa-miR-29c-3p COL6A3 -0.0652732378039769 0.563774115756922 0.634653480531805 2.31261246968383e-05 MirTarget;miRNATAP -0.288244757618725 2.13967705729232e-10 NA NA NA hsa-miR-320a COL6A3 -0.287921276129346 0.00141693637596294 0.634653480531805 2.31261246968383e-05 miRanda -0.201176748305143 0.000453248407381851 NA NA NA hsa-miR-320b COL6A3 0.412787504747938 0.00113457276903985 0.634653480531805 2.31261246968383e-05 miRanda -0.167413670186361 4.06185936806191e-05 NA NA NA hsa-miR-330-3p COL6A3 0.432728362037032 0.00041335506960812 0.634653480531805 2.31261246968383e-05 miRNATAP -0.133167329635563 0.00179688706587385 NA NA NA hsa-miR-429 COL6A3 2.84108892259147 3.88520896426515e-64 0.634653480531805 2.31261246968383e-05 miRNATAP -0.156049616870907 3.65967820567379e-08 NA NA NA hsa-miR-590-3p COL6A3 1.27438512890514 1.03164723481469e-23 0.634653480531805 2.31261246968383e-05 miRanda -0.243582975224293 2.98385710508217e-09 NA NA NA hsa-miR-29b-3p COL7A1 0.438847962603729 6.46722433236121e-05 -0.142091114745415 0.525023647095012 MirTarget;miRNATAP -0.542747935984921 2.44914427380192e-15 NA NA NA hsa-miR-365a-3p COL7A1 -1.45032725192851 2.37888098061118e-37 -0.142091114745415 0.525023647095012 MirTarget -0.248970439356741 0.000110988818911626 NA NA NA hsa-miR-574-3p COL7A1 -0.797230714010546 1.13016535722548e-14 -0.142091114745415 0.525023647095012 miRNATAP -0.306338539265568 2.74413004014282e-05 NA NA NA hsa-miR-106a-5p COL8A2 0.574594373206545 0.000145868284001732 0.331058696879189 0.0275530814582222 mirMAP -0.138439287940488 4.41319629811495e-05 NA NA NA hsa-miR-106b-5p COL8A2 1.22477789913175 2.31787213143326e-32 0.331058696879189 0.0275530814582222 mirMAP -0.398908814313443 2.71207201244846e-17 NA NA NA hsa-miR-17-5p COL8A2 0.599531757298529 1.07318660415906e-05 0.331058696879189 0.0275530814582222 mirMAP -0.348918445795748 2.48384063428809e-21 NA NA NA hsa-miR-185-5p COL8A2 0.482334746589337 3.68475879959415e-09 0.331058696879189 0.0275530814582222 mirMAP -0.452572541990335 3.06251207091244e-13 NA NA NA hsa-miR-197-3p COL8A2 -0.526589453596294 3.61594599437195e-06 0.331058696879189 0.0275530814582222 mirMAP -0.203728471207448 6.08162335179227e-06 NA NA NA hsa-miR-20a-5p COL8A2 0.44979911120222 0.000602386964327228 0.331058696879189 0.0275530814582222 mirMAP -0.342282397053286 5.35278333271682e-19 NA NA NA hsa-miR-3127-5p COL8A2 0.903405128081314 1.1325923598273e-12 0.331058696879189 0.0275530814582222 MirTarget -0.225218960759661 1.54626280616974e-08 NA NA NA hsa-miR-335-5p COL8A2 -2.61355235628987 2.6462884165886e-51 0.331058696879189 0.0275530814582222 miRNAWalker2_validate -0.129867965752422 3.01390660648351e-06 NA NA NA hsa-miR-361-3p COL8A2 -0.0370446538644886 0.624902392829872 0.331058696879189 0.0275530814582222 MirTarget;mirMAP -0.461687621874418 1.0826514972806e-11 NA NA NA hsa-miR-625-5p COL8A2 0.728939236913178 5.97591217674307e-08 0.331058696879189 0.0275530814582222 MirTarget -0.175405565148437 7.50020394040756e-06 NA NA NA hsa-miR-542-3p COPA 0.568822103820889 8.5699075257651e-07 0.719547566689791 7.52804288493045e-26 miRanda -0.140142793297413 1.02999239295943e-11 NA NA NA hsa-miR-342-3p CRLF1 1.21944481975657 6.81914373001202e-19 -0.419734141417057 0.0758779195829251 miRanda -0.358221439777043 3.95507164987894e-10 NA NA NA hsa-miR-375 CRLF1 2.09893673049766 1.68351780396203e-16 -0.419734141417057 0.0758779195829251 miRNAWalker2_validate -0.105784528285738 0.000686867816230096 NA NA NA hsa-miR-16-2-3p CTGF 0.286355254959005 0.0256946046884474 -0.492053877527233 0.000535095367324139 MirTarget -0.281591567371326 9.36643387330157e-14 NA NA NA hsa-miR-18a-5p CTGF 0.969066793715868 1.69069796425892e-08 -0.492053877527233 0.000535095367324139 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.119846814285957 2.0448230920207e-05 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-19a-3p CTGF 0.817507952171848 3.76285090469625e-08 -0.492053877527233 0.000535095367324139 MirTarget;miRNATAP -0.164903918611996 3.73847281655573e-07 NA NA NA hsa-miR-19b-3p CTGF 0.139124391010031 0.255658553872934 -0.492053877527233 0.000535095367324139 MirTarget;miRNATAP -0.161266734152368 5.31562756662891e-05 NA NA NA hsa-miR-330-3p CTGF 0.432728362037032 0.00041335506960812 -0.492053877527233 0.000535095367324139 MirTarget;PITA;miRNATAP -0.167622175608169 3.13598062797761e-05 NA NA NA hsa-miR-361-3p CTGF -0.0370446538644886 0.624902392829872 -0.492053877527233 0.000535095367324139 MirTarget;miRNATAP -0.185041203403867 0.0044938981231653 NA NA NA hsa-miR-375 CTGF 2.09893673049766 1.68351780396203e-16 -0.492053877527233 0.000535095367324139 miRNAWalker2_validate;miRanda -0.104861961985773 1.91267729749617e-08 NA NA NA hsa-miR-590-3p CTGF 1.27438512890514 1.03164723481469e-23 -0.492053877527233 0.000535095367324139 PITA;miRanda -0.260888567866293 1.61748443001636e-11 NA NA NA hsa-miR-7-1-3p CTGF 0.686579567507582 1.20731554448806e-07 -0.492053877527233 0.000535095367324139 MirTarget -0.267500589922773 4.43151453305981e-13 NA NA NA hsa-miR-30a-5p CTHRC1 -0.392489994825279 0.00954894667761676 2.42953191081835 3.60126977652986e-58 MirTarget -0.273708997052506 4.40513608032252e-14 NA NA NA hsa-miR-30b-5p CTHRC1 -0.46540603860146 2.4709940429591e-05 2.42953191081835 3.60126977652986e-58 MirTarget -0.378244947584172 2.78679173797243e-14 26388700 MiR-30b was down-regulated and Cthrc1 up-regulated in NSCLC tissues; Bioinformatics analysis identified Cthrc1 as a target of miR-30b and western blotting and luciferase reporter assays confirmed that miR-30b regulates Cthrc1 by directly binding to its 3'UTR; Transfection of Cthrc1 without the 3'UTR restored the miR-30b inhibiting cell invasion; Up-regulation of miR-30b or down-regulation of Cthrc1 had potential significance in the invasion and metastasis of NSCLC; MiR-30b was down-regulated and Cthrc1 up-regulated in NSCLC tissues; MiR-30b affected NSCLC cells invasion and migration by regulating Cthrc1 metastasis lung squamous cell cancer hsa-miR-30c-5p CTHRC1 -0.393222674580066 8.06961465717306e-05 2.42953191081835 3.60126977652986e-58 MirTarget -0.468955288427919 1.2650546580604e-17 NA NA NA hsa-miR-30d-5p CTHRC1 -0.247082219011045 0.00406717930063148 2.42953191081835 3.60126977652986e-58 MirTarget -0.470423546453568 2.53760348179774e-13 NA NA NA hsa-miR-30e-5p CTHRC1 0.293491764699475 0.000372291967271834 2.42953191081835 3.60126977652986e-58 MirTarget -0.283437753546492 2.85641601300976e-05 NA NA NA hsa-miR-335-3p CTHRC1 -1.88448538773649 2.09538234398335e-32 2.42953191081835 3.60126977652986e-58 MirTarget -0.198736056412729 2.74545474119923e-09 NA NA NA hsa-miR-335-5p CTHRC1 -2.61355235628987 2.6462884165886e-51 2.42953191081835 3.60126977652986e-58 miRNAWalker2_validate -0.287995884753008 1.36354630376811e-22 NA NA NA hsa-miR-141-3p CXCL12 2.99777540204168 1.26370498493024e-78 -2.12095060237474 3.84001932998671e-54 miRNATAP -0.448767864284497 1.69254754152554e-65 NA NA NA hsa-miR-16-2-3p CXCL12 0.286355254959005 0.0256946046884474 -2.12095060237474 3.84001932998671e-54 mirMAP -0.294246189269767 3.69900343948514e-14 NA NA NA hsa-miR-200a-3p CXCL12 2.55218480823434 2.96135446816238e-51 -2.12095060237474 3.84001932998671e-54 miRNATAP -0.360989618953587 4.22159254970216e-42 NA NA NA hsa-miR-301a-3p CXCL12 1.32170168375632 2.12280368957514e-15 -2.12095060237474 3.84001932998671e-54 miRNATAP -0.346200368963609 1.38031855000373e-33 NA NA NA hsa-miR-30d-5p CXCL12 -0.247082219011045 0.00406717930063148 -2.12095060237474 3.84001932998671e-54 mirMAP -0.246089821801855 2.63672409622365e-05 NA NA NA hsa-miR-320b CXCL12 0.412787504747938 0.00113457276903985 -2.12095060237474 3.84001932998671e-54 miRanda -0.243993417539567 6.20238010298801e-10 NA NA NA hsa-miR-375 CXCL12 2.09893673049766 1.68351780396203e-16 -2.12095060237474 3.84001932998671e-54 PITA;miRanda -0.130667047793173 8.04931756867824e-12 NA NA NA hsa-miR-429 CXCL12 2.84108892259147 3.88520896426515e-64 -2.12095060237474 3.84001932998671e-54 miRanda;miRNATAP -0.378344732495558 2.69106217688879e-47 NA NA NA hsa-miR-532-5p CXCL12 0.0386976222860582 0.682018574136515 -2.12095060237474 3.84001932998671e-54 PITA;miRNATAP -0.206941742761165 0.000106529095093586 NA NA NA hsa-miR-590-3p CXCL12 1.27438512890514 1.03164723481469e-23 -2.12095060237474 3.84001932998671e-54 PITA;miRanda;mirMAP -0.38652358664164 6.84901353457739e-23 NA NA NA hsa-miR-625-5p CXCL12 0.728939236913178 5.97591217674307e-08 -2.12095060237474 3.84001932998671e-54 MirTarget -0.15863740568237 3.31006578391849e-05 NA NA NA hsa-miR-629-3p CXCL12 1.25035919247365 3.91361135469024e-14 -2.12095060237474 3.84001932998671e-54 MirTarget -0.253415036671602 7.22045551434004e-17 NA NA NA hsa-miR-96-5p CXCL12 3.24596558166606 1.92296159041707e-98 -2.12095060237474 3.84001932998671e-54 mirMAP -0.443550931300625 2.61489112931284e-61 NA NA NA hsa-miR-375 CXCL6 2.09893673049766 1.68351780396203e-16 -1.94795420724642 3.10169096356284e-12 miRanda -0.300338474424163 2.80312431457939e-16 NA NA NA hsa-miR-181b-5p CYR61 1.22749257795094 1.21998198830919e-27 -1.67425963822887 4.63799641068601e-30 miRNATAP -0.18244691701637 4.77988967740503e-05 NA NA NA hsa-miR-331-5p CYR61 0.682437632502949 4.10871642662371e-11 -1.67425963822887 4.63799641068601e-30 miRNATAP -0.414468314972423 4.86306173771647e-17 NA NA NA hsa-miR-429 CYR61 2.84108892259147 3.88520896426515e-64 -1.67425963822887 4.63799641068601e-30 miRanda -0.284265619579479 4.66070827542544e-24 NA NA NA hsa-miR-106a-5p DAB2 0.574594373206545 0.000145868284001732 -1.07441706975354 3.51977408409549e-29 MirTarget;miRNATAP -0.110642498123511 7.20102599151154e-07 NA NA NA hsa-miR-106b-5p DAB2 1.22477789913175 2.31787213143326e-32 -1.07441706975354 3.51977408409549e-29 MirTarget;miRNATAP -0.372207372927903 2.25720066477648e-34 26769181 The expression of the miR-106b target gene DAB2 in human cervical tissues and cell lines were measured by qRT-PCR western blot and immunohistochemistry; DAB2 a predicted target gene of miR-106b was inhibited by TGF-β1 partly through miR-106b and was involved in TGF-β1-induced cervical cancer cell migration; The expression of DAB2 was low in cervical cancer tissues and negatively correlated with miR-106b expression cell migration cervical and endocervical cancer hsa-miR-17-5p DAB2 0.599531757298529 1.07318660415906e-05 -1.07441706975354 3.51977408409549e-29 MirTarget;TargetScan;miRNATAP -0.238915343637158 6.55283426508591e-23 NA NA NA hsa-miR-20a-5p DAB2 0.44979911120222 0.000602386964327228 -1.07441706975354 3.51977408409549e-29 MirTarget;miRNATAP -0.280150831790743 4.75523383789527e-29 NA NA NA hsa-miR-320b DAB2 0.412787504747938 0.00113457276903985 -1.07441706975354 3.51977408409549e-29 PITA;miRanda;miRNATAP -0.114447377349507 2.05227984923973e-05 NA NA NA hsa-miR-330-5p DAB2 0.626063225953928 3.42215028606779e-09 -1.07441706975354 3.51977408409549e-29 miRanda -0.134124380972254 2.51827588530605e-05 NA NA NA hsa-miR-331-5p DAB2 0.682437632502949 4.10871642662371e-11 -1.07441706975354 3.51977408409549e-29 PITA -0.209874636574808 9.52853121899901e-11 NA NA NA hsa-miR-590-3p DAB2 1.27438512890514 1.03164723481469e-23 -1.07441706975354 3.51977408409549e-29 miRanda;mirMAP -0.190638774347047 1.47503960177777e-12 NA NA NA hsa-miR-590-5p DAB2 0.746515607868274 8.51300479640125e-09 -1.07441706975354 3.51977408409549e-29 miRanda -0.176863664250741 6.68003264565568e-12 NA NA NA hsa-miR-93-5p DAB2 1.01788600209314 1.24312921618126e-21 -1.07441706975354 3.51977408409549e-29 MirTarget;miRNATAP -0.388383970265479 7.36803225019625e-39 24037530 miR 93 directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer; We next identify that microRNA miR-93 functions as a potent repressor of DAB2 expression by directly targeting the 3'UTR of the DAB2 mRNA; Using in vitro and in vivo approaches we demonstrate that miR-93 overexpression has an important role in promoting lung cancer cell growth and that its oncogenic function is primarily mediated by downregulating DAB2 expression; The correlations of both low DAB2 and high miR-93 expression levels with poor patient survival strongly support the critical role of the miR-93/DAB2 pathway in determining lung cancer progression progression;poor survival lung cancer hsa-miR-96-5p DAB2 3.24596558166606 1.92296159041707e-98 -1.07441706975354 3.51977408409549e-29 MirTarget;TargetScan -0.268148098241347 1.41302138361175e-47 NA NA NA hsa-let-7d-5p DCN 0.410958462607207 6.07808182756787e-06 -2.24189494854445 3.67472421736277e-35 MirTarget -0.402955453367597 1.36046683351098e-08 NA NA NA hsa-let-7g-5p DCN 0.0200025784917734 0.791635298815256 -2.24189494854445 3.67472421736277e-35 MirTarget -0.303726193013156 0.000445615748265266 NA NA NA hsa-miR-181a-5p DCN 0.635863607630183 6.72486918157744e-11 -2.24189494854445 3.67472421736277e-35 MirTarget -0.252752904906497 0.000128654659180327 NA NA NA hsa-miR-181b-5p DCN 1.22749257795094 1.21998198830919e-27 -2.24189494854445 3.67472421736277e-35 MirTarget -0.396219797750911 6.579807345297e-13 NA NA NA hsa-miR-181c-5p DCN 0.574847839298605 4.51287502066478e-07 -2.24189494854445 3.67472421736277e-35 MirTarget -0.293525013757079 1.96602577911095e-07 NA NA NA hsa-miR-181d-5p DCN 0.782618466877349 1.2821116358212e-09 -2.24189494854445 3.67472421736277e-35 MirTarget -0.324337485034118 5.14263997474735e-11 NA NA NA hsa-miR-186-5p DCN -0.426987301460247 1.04129380549315e-05 -2.24189494854445 3.67472421736277e-35 mirMAP -0.232351831760879 0.000515456316071472 NA NA NA hsa-miR-320b DCN 0.412787504747938 0.00113457276903985 -2.24189494854445 3.67472421736277e-35 miRanda -0.29535554536257 7.09538047060049e-09 NA NA NA hsa-miR-342-3p DCN 1.21944481975657 6.81914373001202e-19 -2.24189494854445 3.67472421736277e-35 miRanda -0.287211968356635 3.67914088909684e-10 NA NA NA hsa-miR-590-3p DCN 1.27438512890514 1.03164723481469e-23 -2.24189494854445 3.67472421736277e-35 MirTarget;PITA;miRanda;mirMAP -0.52916176505448 1.07716522597725e-25 NA NA NA hsa-miR-7-1-3p DCN 0.686579567507582 1.20731554448806e-07 -2.24189494854445 3.67472421736277e-35 mirMAP -0.417482536233104 1.14965997799617e-17 NA NA NA hsa-miR-98-5p DCN 0.656336869298973 9.03113188590466e-15 -2.24189494854445 3.67472421736277e-35 MirTarget -0.691424742968624 1.12225257396507e-20 NA NA NA hsa-miR-107 DPYSL3 0.678998026350662 2.56224148930538e-16 -0.677451473132496 4.89051442199237e-08 miRanda -0.319090236147184 3.06848137679839e-10 NA NA NA hsa-miR-141-3p DPYSL3 2.99777540204168 1.26370498493024e-78 -0.677451473132496 4.89051442199237e-08 TargetScan -0.288398873329492 3.88589665477977e-35 NA NA NA hsa-miR-141-5p DPYSL3 2.38411349683216 4.56310582620282e-58 -0.677451473132496 4.89051442199237e-08 MirTarget -0.258593507351834 5.17646165832613e-23 NA NA NA hsa-miR-25-3p DPYSL3 -0.00546790775985073 0.944061771389468 -0.677451473132496 4.89051442199237e-08 mirMAP -0.245725351765592 9.16345950359832e-06 NA NA NA hsa-miR-26b-5p DPYSL3 -0.331527896896866 0.000551258576575092 -0.677451473132496 4.89051442199237e-08 miRNAWalker2_validate -0.146476424170446 0.00106672389586539 NA NA NA hsa-miR-29b-3p DPYSL3 0.438847962603729 6.46722433236121e-05 -0.677451473132496 4.89051442199237e-08 MirTarget -0.421927937559975 4.60469636148058e-29 NA NA NA hsa-miR-29c-3p DPYSL3 -0.0652732378039769 0.563774115756922 -0.677451473132496 4.89051442199237e-08 MirTarget -0.329240104983789 1.07044837260393e-18 NA NA NA hsa-miR-320b DPYSL3 0.412787504747938 0.00113457276903985 -0.677451473132496 4.89051442199237e-08 miRNATAP -0.104553019747778 0.00208384974796728 NA NA NA hsa-miR-330-3p DPYSL3 0.432728362037032 0.00041335506960812 -0.677451473132496 4.89051442199237e-08 MirTarget;PITA;miRNATAP -0.128740176541035 0.000276662278670625 NA NA NA hsa-miR-375 DPYSL3 2.09893673049766 1.68351780396203e-16 -0.677451473132496 4.89051442199237e-08 miRNAWalker2_validate -0.142654753862139 1.11387734445944e-18 NA NA NA hsa-miR-423-3p DPYSL3 0.338351552541003 0.000947983901628776 -0.677451473132496 4.89051442199237e-08 miRNAWalker2_validate -0.199741060245155 1.75820327050661e-06 NA NA NA hsa-miR-590-3p DPYSL3 1.27438512890514 1.03164723481469e-23 -0.677451473132496 4.89051442199237e-08 miRanda;mirMAP -0.186307124010398 4.96845863639606e-08 NA NA NA hsa-let-7e-5p DST 0.261471269338985 0.00191077095550257 -2.65768728199613 1.49859497194328e-82 miRNATAP -0.233405536958562 0.000192215134190498 NA NA NA hsa-miR-106a-5p DST 0.574594373206545 0.000145868284001732 -2.65768728199613 1.49859497194328e-82 mirMAP -0.133756926227996 0.00010976449221975 NA NA NA hsa-miR-106b-5p DST 1.22477789913175 2.31787213143326e-32 -2.65768728199613 1.49859497194328e-82 mirMAP -0.622736419087497 1.13429469682054e-40 NA NA NA hsa-miR-130b-5p DST 1.0573161199584 2.55177349228739e-12 -2.65768728199613 1.49859497194328e-82 mirMAP -0.199769909583285 4.54239872002115e-09 NA NA NA hsa-miR-141-3p DST 2.99777540204168 1.26370498493024e-78 -2.65768728199613 1.49859497194328e-82 mirMAP -0.3846762141789 4.60517241267005e-42 NA NA NA hsa-miR-15b-3p DST 1.12898579025388 1.18050912917317e-14 -2.65768728199613 1.49859497194328e-82 mirMAP -0.341572771808693 3.37035543598083e-23 NA NA NA hsa-miR-16-1-3p DST 1.30142784811196 2.53343713753744e-29 -2.65768728199613 1.49859497194328e-82 mirMAP -0.489306872180699 1.6941448519829e-27 NA NA NA hsa-miR-16-2-3p DST 0.286355254959005 0.0256946046884474 -2.65768728199613 1.49859497194328e-82 mirMAP -0.223643570096341 4.82558969351406e-08 NA NA NA hsa-miR-17-3p DST 0.721439431208839 7.95900548819742e-10 -2.65768728199613 1.49859497194328e-82 mirMAP;miRNATAP -0.332147011651542 3.23703460609784e-14 NA NA NA hsa-miR-17-5p DST 0.599531757298529 1.07318660415906e-05 -2.65768728199613 1.49859497194328e-82 mirMAP -0.254460743255582 2.19748432967374e-11 NA NA NA hsa-miR-183-5p DST 2.95681814393872 1.09965777344285e-92 -2.65768728199613 1.49859497194328e-82 mirMAP -0.431912743648347 2.30351112649499e-45 NA NA NA hsa-miR-18a-5p DST 0.969066793715868 1.69069796425892e-08 -2.65768728199613 1.49859497194328e-82 mirMAP -0.253594711302634 1.70338130586849e-17 NA NA NA hsa-miR-192-5p DST 1.33366224451777 9.5116159697107e-29 -2.65768728199613 1.49859497194328e-82 miRNAWalker2_validate;mirMAP -0.346902516327788 8.1171721046008e-17 NA NA NA hsa-miR-19b-1-5p DST 0.647704962003062 3.07687667945597e-07 -2.65768728199613 1.49859497194328e-82 mirMAP -0.173052058802987 2.69350960949974e-05 NA NA NA hsa-miR-200a-3p DST 2.55218480823434 2.96135446816238e-51 -2.65768728199613 1.49859497194328e-82 mirMAP -0.289656110108089 2.18967385872587e-24 NA NA NA hsa-miR-200b-3p DST 2.11744072703209 1.66710572104191e-43 -2.65768728199613 1.49859497194328e-82 mirMAP -0.293585785496736 2.54473459359641e-20 NA NA NA hsa-miR-200c-3p DST 2.07038651806183 6.84613386286599e-51 -2.65768728199613 1.49859497194328e-82 mirMAP -0.367710964272576 2.86982979480575e-26 NA NA NA hsa-miR-20a-5p DST 0.44979911120222 0.000602386964327228 -2.65768728199613 1.49859497194328e-82 mirMAP -0.24098441718992 1.26540616707325e-09 NA NA NA hsa-miR-20b-5p DST 0.78236583455125 8.7938334801223e-05 -2.65768728199613 1.49859497194328e-82 mirMAP -0.114249110877242 1.24976060131441e-05 NA NA NA hsa-miR-21-5p DST 2.32007501846389 3.08394781855554e-137 -2.65768728199613 1.49859497194328e-82 mirMAP -0.658195712040471 2.03281374044393e-48 22403704 While the EDCs and estrogen similarly altered the expression of multiple microRNAs in MCF-7 cells including miR-21 differential patterns of microRNA expression were induced by DDT and BPA compared to estrogen breast cancer hsa-miR-25-3p DST -0.00546790775985073 0.944061771389468 -2.65768728199613 1.49859497194328e-82 mirMAP -0.309709625789615 4.97714432198926e-06 NA NA NA hsa-miR-27a-3p DST 0.388496361379095 1.42373532086331e-05 -2.65768728199613 1.49859497194328e-82 mirMAP -0.25278382805404 1.60468962891302e-05 NA NA NA hsa-miR-3065-3p DST 1.62787885002468 6.81477830005026e-19 -2.65768728199613 1.49859497194328e-82 mirMAP -0.148851958667732 8.99709650045668e-08 NA NA NA hsa-miR-30d-3p DST 0.264544633563642 0.00755023189129747 -2.65768728199613 1.49859497194328e-82 mirMAP -0.181218018476373 0.0006607319821749 NA NA NA hsa-miR-3127-5p DST 0.903405128081314 1.1325923598273e-12 -2.65768728199613 1.49859497194328e-82 mirMAP -0.342040269611558 1.53570166680379e-17 NA NA NA hsa-miR-32-5p DST 1.38676603945192 2.29428299685976e-34 -2.65768728199613 1.49859497194328e-82 miRNAWalker2_validate;mirMAP -0.471792872423766 6.41826512474014e-28 NA NA NA hsa-miR-320b DST 0.412787504747938 0.00113457276903985 -2.65768728199613 1.49859497194328e-82 mirMAP -0.183682351471898 9.5308402368832e-06 NA NA NA hsa-miR-330-3p DST 0.432728362037032 0.00041335506960812 -2.65768728199613 1.49859497194328e-82 mirMAP -0.229360476522829 1.08569427330416e-07 NA NA NA hsa-miR-330-5p DST 0.626063225953928 3.42215028606779e-09 -2.65768728199613 1.49859497194328e-82 miRanda;mirMAP -0.331826848273591 1.00755401760864e-11 NA NA NA hsa-miR-33a-5p DST 1.35185127289399 9.80509199125785e-12 -2.65768728199613 1.49859497194328e-82 mirMAP -0.175908747927284 2.48538188753248e-11 NA NA NA hsa-miR-345-5p DST 0.639728356429512 0.00013070715719672 -2.65768728199613 1.49859497194328e-82 mirMAP -0.134298466086887 1.68432675129012e-05 NA NA NA hsa-miR-361-5p DST -0.0996867547900457 0.095428250126326 -2.65768728199613 1.49859497194328e-82 mirMAP -0.231866087247584 0.00953550628531308 NA NA NA hsa-miR-362-5p DST -0.248676340901797 0.0726089851456282 -2.65768728199613 1.49859497194328e-82 TargetScan;mirMAP -0.159333984205102 2.57197521802183e-05 NA NA NA hsa-miR-429 DST 2.84108892259147 3.88520896426515e-64 -2.65768728199613 1.49859497194328e-82 miRanda;mirMAP;miRNATAP -0.335369004875444 2.7974997525439e-33 NA NA NA hsa-miR-484 DST 0.349444060004737 0.00154491249625173 -2.65768728199613 1.49859497194328e-82 miRNAWalker2_validate -0.302140350456737 1.53474678087428e-10 NA NA NA hsa-miR-500a-3p DST 0.139523673241448 0.185528510741158 -2.65768728199613 1.49859497194328e-82 mirMAP -0.246066796073583 7.84211474793576e-07 NA NA NA hsa-miR-532-5p DST 0.0386976222860582 0.682018574136515 -2.65768728199613 1.49859497194328e-82 mirMAP -0.183860189146139 0.00100984091990921 NA NA NA hsa-miR-590-3p DST 1.27438512890514 1.03164723481469e-23 -2.65768728199613 1.49859497194328e-82 PITA;miRanda;mirMAP -0.362948210353927 1.45993733309567e-18 NA NA NA hsa-miR-590-5p DST 0.746515607868274 8.51300479640125e-09 -2.65768728199613 1.49859497194328e-82 mirMAP -0.244920414501756 8.39611228797819e-10 NA NA NA hsa-miR-615-3p DST 0.659240580933614 0.000360214386152507 -2.65768728199613 1.49859497194328e-82 miRNAWalker2_validate -0.149671586544779 1.11967077864293e-07 NA NA NA hsa-miR-629-3p DST 1.25035919247365 3.91361135469024e-14 -2.65768728199613 1.49859497194328e-82 mirMAP -0.172021580319008 8.7806448271034e-08 NA NA NA hsa-miR-629-5p DST 0.42411327890895 2.46262300605706e-05 -2.65768728199613 1.49859497194328e-82 mirMAP -0.227798253742312 1.22153438217008e-05 NA NA NA hsa-miR-708-3p DST 0.478640655706813 2.13865852505288e-05 -2.65768728199613 1.49859497194328e-82 MirTarget -0.16059795022082 0.000557124113032931 NA NA NA hsa-miR-92b-3p DST 1.30248132773644 9.42428674470985e-25 -2.65768728199613 1.49859497194328e-82 mirMAP -0.343669996061883 3.24959422287383e-18 NA NA NA hsa-miR-93-5p DST 1.01788600209314 1.24312921618126e-21 -2.65768728199613 1.49859497194328e-82 mirMAP -0.592813484593144 6.74203529223573e-38 NA NA NA hsa-miR-99b-3p DST 0.617175730947012 6.04327581183627e-09 -2.65768728199613 1.49859497194328e-82 mirMAP -0.303149257395589 5.21462489014948e-10 NA NA NA hsa-miR-140-5p ECM1 -0.755971041589807 9.68060922934542e-14 1.09554661761308 1.23280400578586e-08 miRanda -0.309330823683822 1.61390609676957e-06 NA NA NA hsa-miR-142-3p ECM2 1.53951237846104 2.06769936282034e-17 -2.56935678145274 1.55041125018358e-60 miRanda;miRNATAP -0.167318896987274 7.45758286875347e-08 NA NA NA hsa-miR-16-2-3p ECM2 0.286355254959005 0.0256946046884474 -2.56935678145274 1.55041125018358e-60 mirMAP -0.326456393593709 3.46485520066163e-13 NA NA NA hsa-miR-30d-3p ECM2 0.264544633563642 0.00755023189129747 -2.56935678145274 1.55041125018358e-60 MirTarget -0.491120246288752 1.56821667636385e-17 NA NA NA hsa-miR-320b ECM2 0.412787504747938 0.00113457276903985 -2.56935678145274 1.55041125018358e-60 miRanda -0.263371267884043 7.40339768147384e-09 NA NA NA hsa-miR-331-5p ECM2 0.682437632502949 4.10871642662371e-11 -2.56935678145274 1.55041125018358e-60 MirTarget -0.430879090540797 4.14435978073395e-15 NA NA NA hsa-miR-340-5p ECM2 1.0857159627596 4.94471062546756e-24 -2.56935678145274 1.55041125018358e-60 mirMAP -0.459645600129004 4.59636346820296e-19 NA NA NA hsa-miR-342-3p ECM2 1.21944481975657 6.81914373001202e-19 -2.56935678145274 1.55041125018358e-60 miRanda -0.277722624847942 1.03422404254714e-11 NA NA NA hsa-miR-590-3p ECM2 1.27438512890514 1.03164723481469e-23 -2.56935678145274 1.55041125018358e-60 MirTarget;miRanda;miRNATAP -0.537040434808036 2.37807621984613e-33 NA NA NA hsa-miR-590-5p ECM2 0.746515607868274 8.51300479640125e-09 -2.56935678145274 1.55041125018358e-60 miRanda -0.461956199041912 6.62098792236303e-27 NA NA NA hsa-miR-7-1-3p ECM2 0.686579567507582 1.20731554448806e-07 -2.56935678145274 1.55041125018358e-60 MirTarget -0.298762803892047 1.00424233103104e-11 NA NA NA hsa-miR-98-5p ECM2 0.656336869298973 9.03113188590466e-15 -2.56935678145274 1.55041125018358e-60 miRNAWalker2_validate -0.65097794705528 6.07561495920155e-23 NA NA NA hsa-miR-107 EDIL3 0.678998026350662 2.56224148930538e-16 -0.548013396950836 0.0239358726421537 miRanda -0.779670015001692 1.4557512037148e-15 NA NA NA hsa-miR-16-2-3p EDIL3 0.286355254959005 0.0256946046884474 -0.548013396950836 0.0239358726421537 mirMAP -0.326535381683094 5.10847010770929e-07 NA NA NA hsa-miR-182-5p EDIL3 2.36408084103818 2.60011457600281e-72 -0.548013396950836 0.0239358726421537 MirTarget -0.154224143674225 0.00772099786995928 NA NA NA hsa-miR-335-3p EDIL3 -1.88448538773649 2.09538234398335e-32 -0.548013396950836 0.0239358726421537 MirTarget -0.148697364224326 0.00312084730869356 NA NA NA hsa-miR-340-5p EDIL3 1.0857159627596 4.94471062546756e-24 -0.548013396950836 0.0239358726421537 mirMAP -0.655205713554836 9.12106478093677e-19 NA NA NA hsa-miR-361-5p EDIL3 -0.0996867547900457 0.095428250126326 -0.548013396950836 0.0239358726421537 MirTarget;miRanda -1.11694351435345 1.09991414441357e-15 NA NA NA hsa-miR-374a-3p EDIL3 0.34122393953022 2.28714105382856e-05 -0.548013396950836 0.0239358726421537 MirTarget -0.413540447315725 6.42075691011419e-05 NA NA NA hsa-miR-374a-5p EDIL3 -0.239709888246804 0.00309819667153627 -0.548013396950836 0.0239358726421537 mirMAP -0.599347091072491 5.15477199328869e-09 NA NA NA hsa-miR-374b-5p EDIL3 -0.466781429946153 1.17238311619116e-08 -0.548013396950836 0.0239358726421537 mirMAP -0.35988474771887 0.000391527245180108 NA NA NA hsa-miR-425-5p EDIL3 0.719898949241718 6.01079610190374e-08 -0.548013396950836 0.0239358726421537 MirTarget -0.197202616972325 0.00152921240086566 NA NA NA hsa-miR-590-3p EDIL3 1.27438512890514 1.03164723481469e-23 -0.548013396950836 0.0239358726421537 miRanda;mirMAP -0.435076043230119 4.51363688228842e-11 NA NA NA hsa-miR-590-5p EDIL3 0.746515607868274 8.51300479640125e-09 -0.548013396950836 0.0239358726421537 MirTarget;miRNATAP -0.323009912323896 3.57062763458166e-07 NA NA NA hsa-miR-128-3p EFEMP2 0.90296715955238 9.925204823863e-23 -0.523529763383355 6.87459497602457e-07 miRNAWalker2_validate -0.207472285444795 6.6322832841084e-08 NA NA NA hsa-miR-324-3p EFEMP2 0.404877731996915 0.000340036423920834 -0.523529763383355 6.87459497602457e-07 MirTarget -0.293256527548864 1.06304227419235e-20 NA NA NA hsa-miR-330-5p EFEMP2 0.626063225953928 3.42215028606779e-09 -0.523529763383355 6.87459497602457e-07 miRanda -0.288616289734109 6.40351014372744e-18 NA NA NA hsa-miR-629-3p EFEMP2 1.25035919247365 3.91361135469024e-14 -0.523529763383355 6.87459497602457e-07 MirTarget -0.247071146664913 2.58377020996576e-30 NA NA NA hsa-miR-29b-3p ELN 0.438847962603729 6.46722433236121e-05 -0.310025781931611 0.132934884857683 MirTarget;miRNATAP -0.60230437226549 8.36950794742073e-22 NA NA NA hsa-miR-331-3p ELN 0.74441480542886 1.17071235477799e-07 -0.310025781931611 0.132934884857683 MirTarget;PITA -0.526165037693724 1.67665459811601e-27 NA NA NA hsa-miR-361-3p ELN -0.0370446538644886 0.624902392829872 -0.310025781931611 0.132934884857683 PITA;mirMAP -0.304427880497247 0.00123715129452102 NA NA NA hsa-miR-423-5p ELN -0.0644843381453004 0.462275547464843 -0.310025781931611 0.132934884857683 MirTarget -0.337096412769453 3.14332101144679e-05 NA NA NA hsa-miR-429 ELN 2.84108892259147 3.88520896426515e-64 -0.310025781931611 0.132934884857683 miRNATAP -0.258833056070117 2.14430384622947e-11 NA NA NA hsa-miR-491-5p ELN -1.04307210952796 1.14586501470398e-15 -0.310025781931611 0.132934884857683 MirTarget;miRanda;miRNATAP -0.190492410533128 0.000391853904339962 NA NA NA hsa-miR-615-3p ELN 0.659240580933614 0.000360214386152507 -0.310025781931611 0.132934884857683 miRanda -0.143685445938281 0.000163759587330653 NA NA NA hsa-miR-30a-5p FAP -0.392489994825279 0.00954894667761676 1.52100689631992 2.08563548734999e-23 miRNATAP -0.245817385335432 2.39698848382924e-12 NA NA NA hsa-miR-30c-5p FAP -0.393222674580066 8.06961465717306e-05 1.52100689631992 2.08563548734999e-23 miRNATAP -0.498091347484859 3.31925640788605e-21 NA NA NA hsa-miR-30d-5p FAP -0.247082219011045 0.00406717930063148 1.52100689631992 2.08563548734999e-23 miRNATAP -0.554145203845262 2.17388616033825e-19 NA NA NA hsa-let-7a-5p FAS -0.210286642041636 0.0072546234707717 -0.759637724162876 2.18688041634812e-12 TargetScan -0.147010045095826 0.00234531576557678 NA NA NA hsa-miR-338-3p FAS 0.0799903526884966 0.575137668326679 -0.759637724162876 2.18688041634812e-12 miRanda -0.16768795837118 1.3473835302647e-10 NA NA NA hsa-miR-98-5p FAS 0.656336869298973 9.03113188590466e-15 -0.759637724162876 2.18688041634812e-12 miRNAWalker2_validate -0.147800482737569 0.000760862411963529 NA NA NA hsa-miR-107 FBLN1 0.678998026350662 2.56224148930538e-16 -0.991321928153263 4.17334822650844e-13 miRanda -0.227264385573648 5.9062363730165e-05 NA NA NA hsa-miR-193a-3p FBLN1 0.310617999804917 0.00477640270974957 -0.991321928153263 4.17334822650844e-13 miRanda -0.224900244459198 1.71934114915188e-07 NA NA NA hsa-miR-330-5p FBLN1 0.626063225953928 3.42215028606779e-09 -0.991321928153263 4.17334822650844e-13 miRanda -0.311245315640924 1.6550446113892e-12 NA NA NA hsa-miR-429 FBLN1 2.84108892259147 3.88520896426515e-64 -0.991321928153263 4.17334822650844e-13 miRanda -0.263785640996207 4.95897402728283e-25 NA NA NA hsa-miR-128-3p FBLN2 0.90296715955238 9.925204823863e-23 -1.18887604366734 7.14759250936838e-14 MirTarget -0.274467972787357 2.76453829032226e-06 NA NA NA hsa-miR-744-5p FBLN2 0.114590984077262 0.312916425462546 -1.18887604366734 7.14759250936838e-14 MirTarget -0.353594955374468 2.22276848293573e-13 NA NA NA hsa-miR-200c-3p FBLN5 2.07038651806183 6.84613386286599e-51 -2.08643289665163 1.31128583188143e-54 miRNAWalker2_validate;miRTarBase -0.431582532539337 7.04635991309229e-42 NA NA NA hsa-miR-330-3p FBLN5 0.432728362037032 0.00041335506960812 -2.08643289665163 1.31128583188143e-54 miRNATAP -0.175916177952615 1.44916507462297e-05 NA NA NA hsa-miR-429 FBLN5 2.84108892259147 3.88520896426515e-64 -2.08643289665163 1.31128583188143e-54 miRanda;miRNATAP -0.332874799545084 1.53710744952646e-37 NA NA NA hsa-miR-769-5p FBLN5 0.564871766265874 8.16695101656941e-10 -2.08643289665163 1.31128583188143e-54 PITA -0.440613977684543 3.61869769894262e-17 NA NA NA hsa-let-7a-3p FBN1 0.466622567891891 3.70886257943079e-07 -0.638584226140373 7.0335453791039e-05 mirMAP -0.247039942400931 3.82075966588535e-05 NA NA NA hsa-miR-16-2-3p FBN1 0.286355254959005 0.0256946046884474 -0.638584226140373 7.0335453791039e-05 mirMAP -0.220047043632757 3.41576700371951e-07 NA NA NA hsa-miR-182-5p FBN1 2.36408084103818 2.60011457600281e-72 -0.638584226140373 7.0335453791039e-05 miRNATAP -0.227607365082274 2.34110453365045e-09 NA NA NA hsa-miR-192-5p FBN1 1.33366224451777 9.5116159697107e-29 -0.638584226140373 7.0335453791039e-05 miRNAWalker2_validate -0.234776889127393 1.19518362778755e-07 NA NA NA hsa-miR-19b-1-5p FBN1 0.647704962003062 3.07687667945597e-07 -0.638584226140373 7.0335453791039e-05 mirMAP -0.406748669754672 9.16604267557924e-22 NA NA NA hsa-miR-25-3p FBN1 -0.00546790775985073 0.944061771389468 -0.638584226140373 7.0335453791039e-05 mirMAP -0.559427512001055 2.06485745783674e-15 NA NA NA hsa-miR-29b-3p FBN1 0.438847962603729 6.46722433236121e-05 -0.638584226140373 7.0335453791039e-05 miRNATAP -0.433863260140539 1.2979682185639e-18 NA NA NA hsa-miR-29c-3p FBN1 -0.0652732378039769 0.563774115756922 -0.638584226140373 7.0335453791039e-05 miRNAWalker2_validate;miRTarBase -0.3258579629785 1.8804044310973e-11 NA NA NA hsa-miR-30a-5p FBN1 -0.392489994825279 0.00954894667761676 -0.638584226140373 7.0335453791039e-05 miRNAWalker2_validate -0.184707864839378 3.56648146536204e-07 NA NA NA hsa-miR-361-5p FBN1 -0.0996867547900457 0.095428250126326 -0.638584226140373 7.0335453791039e-05 mirMAP -0.48639328579658 1.98948935239576e-07 NA NA NA hsa-miR-374a-5p FBN1 -0.239709888246804 0.00309819667153627 -0.638584226140373 7.0335453791039e-05 mirMAP -0.204777001548154 0.00284223728645302 NA NA NA hsa-miR-429 FBN1 2.84108892259147 3.88520896426515e-64 -0.638584226140373 7.0335453791039e-05 miRNATAP -0.312500240287817 5.3468432970057e-26 NA NA NA hsa-miR-576-5p FBN1 0.0649387707567879 0.588791966096287 -0.638584226140373 7.0335453791039e-05 mirMAP -0.154024172622585 0.000836609498484188 NA NA NA hsa-miR-590-3p FBN1 1.27438512890514 1.03164723481469e-23 -0.638584226140373 7.0335453791039e-05 miRanda;mirMAP -0.322962980755762 1.48650955331962e-13 NA NA NA hsa-miR-92a-3p FBN1 -0.342420481092807 0.000732275969501111 -0.638584226140373 7.0335453791039e-05 mirMAP -0.408646687084083 3.11411207486486e-14 NA NA NA hsa-miR-101-3p FBN2 -0.126035286271986 0.145997832808138 2.86126193436058 1.17556247261121e-35 miRNAWalker2_validate;MirTarget;miRNATAP -0.448886240157524 2.39188245535088e-06 NA NA NA hsa-miR-126-5p FBN2 -1.27745588751177 2.96000918537631e-30 2.86126193436058 1.17556247261121e-35 mirMAP -0.459263630598206 6.89232380784409e-11 NA NA NA hsa-miR-139-5p FBN2 -3.25846663863766 2.62018989415003e-112 2.86126193436058 1.17556247261121e-35 MirTarget;PITA;miRanda;miRNATAP -0.563936158585124 1.80898032753337e-32 NA NA NA hsa-miR-140-3p FBN2 -1.25844395244141 5.29222651039892e-33 2.86126193436058 1.17556247261121e-35 PITA -0.328802169864446 1.20402526607313e-05 NA NA NA hsa-miR-218-5p FBN2 -1.02621788318234 2.9221925445771e-23 2.86126193436058 1.17556247261121e-35 MirTarget;miRNATAP -0.237306085627427 0.00226206351713997 NA NA NA hsa-miR-320a FBN2 -0.287921276129346 0.00141693637596294 2.86126193436058 1.17556247261121e-35 miRanda -0.345387340344757 0.000156655103539894 NA NA NA hsa-miR-335-5p FBN2 -2.61355235628987 2.6462884165886e-51 2.86126193436058 1.17556247261121e-35 miRNAWalker2_validate -0.33833937437666 1.32186374111528e-14 NA NA NA hsa-miR-103a-3p FERMT2 0.610673390034345 1.63113920514646e-12 -1.85633940208907 3.36734523172304e-65 MirTarget -0.475034200465442 6.74324708114109e-26 NA NA NA hsa-miR-107 FERMT2 0.678998026350662 2.56224148930538e-16 -1.85633940208907 3.36734523172304e-65 MirTarget;miRanda;miRNATAP -0.421108139793699 5.64248355005928e-19 NA NA NA hsa-miR-146b-5p FERMT2 0.631041661167954 6.20366593452965e-08 -1.85633940208907 3.36734523172304e-65 miRanda -0.121023628734604 0.000455675193522226 NA NA NA hsa-miR-15a-5p FERMT2 0.812445324157528 4.50263417099822e-20 -1.85633940208907 3.36734523172304e-65 MirTarget;miRNATAP -0.397653920622506 1.56115879674925e-19 NA NA NA hsa-miR-15b-5p FERMT2 0.788659356634696 1.13678211092534e-11 -1.85633940208907 3.36734523172304e-65 MirTarget;miRNATAP -0.200914179234583 4.45575255264162e-09 NA NA NA hsa-miR-16-5p FERMT2 0.46835991343556 1.91125356547776e-06 -1.85633940208907 3.36734523172304e-65 MirTarget;miRNATAP -0.155886573982567 0.00014704342261767 NA NA NA hsa-miR-200b-3p FERMT2 2.11744072703209 1.66710572104191e-43 -1.85633940208907 3.36734523172304e-65 TargetScan -0.385571245951135 5.50529908068042e-62 23483548;24064224;26334393 Here we report that Kindlin 2 markedly downregulates the expression of miR-200 family by inducing CpG island hypermethylation; Our data indicate that Kindlin 2 plays a novel role in epigenetic repression of miR-200 family a mechanism that promotes breast cancer invasion;miR 200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin 2; Quantitative mass spectrometry identified 57 putative miR-200b targets including Kindlin-2 previously implicated in the regulation of tumor invasiveness and actin cytoskeleton in other cell types; Enforced expression of miR-200b mimic in ESCC cells led to a decrease of Kindlin-2 expression whereas transfection of miR-200b inhibitor induced Kindlin-2 expression; Furthermore transfection of miR-200b mimic or knockdown of Kindlin-2 in ESCC cells decreased cell protrusion and focal adhesion FA formation reduced cell spreading and invasiveness/migration; Enforced expression of Kindlin-2 largely abrogated the inhibitory effects of miR-200b on ESCC cell invasiveness; The tumor suppressor effects of miR-200b may be due to its suppression of Kindlin-2 a novel target of miR-200b that modulates actin cytoskeleton FA formation and the migratory/invasiveness properties of ESCC;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ;; breast cancer;esophageal cancer;esophageal cancer hsa-miR-21-5p FERMT2 2.32007501846389 3.08394781855554e-137 -1.85633940208907 3.36734523172304e-65 miRNAWalker2_validate -0.395121625605477 1.35565362055128e-28 NA NA NA hsa-miR-29b-3p FERMT2 0.438847962603729 6.46722433236121e-05 -1.85633940208907 3.36734523172304e-65 MirTarget;miRNATAP -0.310438060175932 8.89430856404995e-18 NA NA NA hsa-miR-29c-3p FERMT2 -0.0652732378039769 0.563774115756922 -1.85633940208907 3.36734523172304e-65 MirTarget;miRNATAP -0.254598460054529 7.39974158447735e-13 NA NA NA hsa-miR-338-3p FERMT2 0.0799903526884966 0.575137668326679 -1.85633940208907 3.36734523172304e-65 miRanda -0.16631976882273 3.72373557342636e-09 NA NA NA hsa-miR-429 FERMT2 2.84108892259147 3.88520896426515e-64 -1.85633940208907 3.36734523172304e-65 miRanda;miRNATAP -0.347643412445339 2.23250122715493e-63 NA NA NA hsa-miR-454-3p FERMT2 1.28177672191095 6.84024979484587e-21 -1.85633940208907 3.36734523172304e-65 miRNATAP -0.219562490260226 1.98820427368722e-14 NA NA NA hsa-miR-590-3p FERMT2 1.27438512890514 1.03164723481469e-23 -1.85633940208907 3.36734523172304e-65 MirTarget;miRanda;mirMAP;miRNATAP -0.286778843790189 1.8512235778103e-19 NA NA NA hsa-miR-590-5p FERMT2 0.746515607868274 8.51300479640125e-09 -1.85633940208907 3.36734523172304e-65 miRanda -0.17711786758587 8.99265789038438e-09 NA NA NA hsa-miR-7-1-3p FERMT2 0.686579567507582 1.20731554448806e-07 -1.85633940208907 3.36734523172304e-65 mirMAP -0.227439721754917 1.09951047515289e-13 NA NA NA hsa-let-7a-3p FGF2 0.466622567891891 3.70886257943079e-07 -3.62110997961421 1.11252046868458e-69 mirMAP -0.291818855316242 0.000475924803881402 NA NA NA hsa-let-7f-1-3p FGF2 0.37532726250321 0.00156021688753682 -3.62110997961421 1.11252046868458e-69 mirMAP -0.20077854516594 0.00221318919252559 NA NA NA hsa-miR-103a-3p FGF2 0.610673390034345 1.63113920514646e-12 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate;MirTarget;miRNATAP -0.723924551136195 6.60361690701997e-17 NA NA NA hsa-miR-107 FGF2 0.678998026350662 2.56224148930538e-16 -3.62110997961421 1.11252046868458e-69 MirTarget;PITA;miRanda;miRNATAP -0.796465331145451 7.23286562379616e-19 NA NA NA hsa-miR-142-3p FGF2 1.53951237846104 2.06769936282034e-17 -3.62110997961421 1.11252046868458e-69 miRanda -0.17283302588329 2.98031372863511e-05 NA NA NA hsa-miR-155-5p FGF2 1.09766314984151 4.55650930885814e-15 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate;mirMAP -0.14901722637598 0.00579079439331683 NA NA NA hsa-miR-15a-5p FGF2 0.812445324157528 4.50263417099822e-20 -3.62110997961421 1.11252046868458e-69 MirTarget;miRNATAP -0.693907136905669 1.18654679034038e-16 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 1.12898579025388 1.18050912917317e-14 -3.62110997961421 1.11252046868458e-69 mirMAP -0.416639852881488 2.41684465169063e-16 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 0.788659356634696 1.13678211092534e-11 -3.62110997961421 1.11252046868458e-69 MirTarget;miRNATAP -0.416542064799323 1.32439928134663e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.30142784811196 2.53343713753744e-29 -3.62110997961421 1.11252046868458e-69 mirMAP -0.618895974599859 1.26519964172122e-20 NA NA NA hsa-miR-16-2-3p FGF2 0.286355254959005 0.0256946046884474 -3.62110997961421 1.11252046868458e-69 mirMAP -0.190718116559883 0.00155781442617599 NA NA NA hsa-miR-16-5p FGF2 0.46835991343556 1.91125356547776e-06 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate;MirTarget;miRNATAP -0.334764026766057 1.68868207410758e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-181a-5p FGF2 0.635863607630183 6.72486918157744e-11 -3.62110997961421 1.11252046868458e-69 mirMAP -0.445820481795785 9.84329484201549e-09 NA NA NA hsa-miR-181b-5p FGF2 1.22749257795094 1.21998198830919e-27 -3.62110997961421 1.11252046868458e-69 mirMAP -0.542719617785167 6.40042754935602e-17 NA NA NA hsa-miR-181c-5p FGF2 0.574847839298605 4.51287502066478e-07 -3.62110997961421 1.11252046868458e-69 mirMAP -0.226227363468224 0.00075162633624824 NA NA NA hsa-miR-192-5p FGF2 1.33366224451777 9.5116159697107e-29 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate -0.492571390734632 6.64406170620692e-16 NA NA NA hsa-miR-19b-1-5p FGF2 0.647704962003062 3.07687667945597e-07 -3.62110997961421 1.11252046868458e-69 mirMAP -0.220669191860133 0.000256708213140997 NA NA NA hsa-miR-200b-3p FGF2 2.11744072703209 1.66710572104191e-43 -3.62110997961421 1.11252046868458e-69 mirMAP -0.474105291344653 1.09246839719196e-24 NA NA NA hsa-miR-200c-3p FGF2 2.07038651806183 6.84613386286599e-51 -3.62110997961421 1.11252046868458e-69 mirMAP -0.615252170517975 1.40903756446366e-34 NA NA NA hsa-miR-21-3p FGF2 2.17476065946878 5.15299442583591e-75 -3.62110997961421 1.11252046868458e-69 mirMAP -0.712905950790447 1.55737305852276e-36 NA NA NA hsa-miR-21-5p FGF2 2.32007501846389 3.08394781855554e-137 -3.62110997961421 1.11252046868458e-69 mirMAP -1.0007316696677 9.45001605861665e-53 NA NA NA hsa-miR-32-5p FGF2 1.38676603945192 2.29428299685976e-34 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate -0.601478209606274 2.96886796474821e-21 NA NA NA hsa-miR-330-3p FGF2 0.432728362037032 0.00041335506960812 -3.62110997961421 1.11252046868458e-69 mirMAP -0.190108192654775 0.00276026518304351 NA NA NA hsa-miR-429 FGF2 2.84108892259147 3.88520896426515e-64 -3.62110997961421 1.11252046868458e-69 mirMAP -0.50658475327409 1.36690059845309e-35 NA NA NA hsa-miR-503-5p FGF2 1.89861508626371 8.64468509978193e-28 -3.62110997961421 1.11252046868458e-69 miRNAWalker2_validate -0.318786957596351 2.28520886786229e-13 NA NA NA hsa-miR-590-3p FGF2 1.27438512890514 1.03164723481469e-23 -3.62110997961421 1.11252046868458e-69 miRanda;mirMAP -0.434908422832851 8.74942691621125e-13 NA NA NA hsa-miR-590-5p FGF2 0.746515607868274 8.51300479640125e-09 -3.62110997961421 1.11252046868458e-69 miRanda;mirMAP -0.340101326786598 5.86637073853323e-09 NA NA NA hsa-miR-93-3p FGF2 0.627759242044891 3.62527588304617e-06 -3.62110997961421 1.11252046868458e-69 mirMAP -0.374363069604572 2.04134280501924e-11 NA NA NA hsa-miR-149-5p FLNA 0.218233101703391 0.261629158371175 -0.588648086634478 1.12488656429227e-08 miRNAWalker2_validate -0.104936764513895 7.86778756479402e-09 NA NA NA hsa-miR-16-5p FLNA 0.46835991343556 1.91125356547776e-06 -0.588648086634478 1.12488656429227e-08 miRNAWalker2_validate -0.172916693939482 1.57998325738482e-06 NA NA NA hsa-miR-200c-3p FLNA 2.07038651806183 6.84613386286599e-51 -0.588648086634478 1.12488656429227e-08 miRNAWalker2_validate -0.200293197507804 3.85868552345297e-17 NA NA NA hsa-miR-125a-3p FMOD -0.176412960953959 0.10108079286419 -1.5830220066125 1.49258819797672e-21 MirTarget;miRanda -0.208256259003663 0.000131422229746125 NA NA NA hsa-miR-1266-5p FMOD 0.413134124142464 0.00276117940829758 -1.5830220066125 1.49258819797672e-21 MirTarget -0.141344703547634 0.000831136272331554 NA NA NA hsa-miR-185-3p FMOD 0.86591374114446 7.8790769678542e-10 -1.5830220066125 1.49258819797672e-21 MirTarget -0.376314797461949 2.92642326562804e-20 NA NA NA hsa-miR-21-5p FMOD 2.32007501846389 3.08394781855554e-137 -1.5830220066125 1.49258819797672e-21 miRNAWalker2_validate;miRTarBase -0.391125968145743 7.97182814844372e-14 23445447;19906824 Our method exhibits ultrahigh sensitivity toward miR-21 with detection limits of 10 fM at 37 °C and 1 aM at 4 °C which corresponds to nine strands of miR-21 in a 15 μL sample and it is capable of distinguishing among miRNA family members;Gain-of miR-21 function in MSMC and LSMC reduced TGF-beta-induced expression of fibromodulin and TGF-beta-induced factor P < 0.05 and moderately altered the rate of cell growth and caspase-3/7 activity in these cells ; breast cancer;sarcoma hsa-miR-330-5p FMOD 0.626063225953928 3.42215028606779e-09 -1.5830220066125 1.49258819797672e-21 miRanda -0.495259487483314 2.34776881665496e-20 NA NA NA hsa-miR-340-5p FMOD 1.0857159627596 4.94471062546756e-24 -1.5830220066125 1.49258819797672e-21 MirTarget -0.290992993195457 3.32136436950448e-08 NA NA NA hsa-miR-429 FMOD 2.84108892259147 3.88520896426515e-64 -1.5830220066125 1.49258819797672e-21 miRNATAP -0.329630400497878 6.4012072914873e-26 NA NA NA hsa-miR-505-5p FMOD -0.842640534241897 4.43022473091907e-09 -1.5830220066125 1.49258819797672e-21 MirTarget -0.173862498113073 1.6172778856963e-05 NA NA NA hsa-miR-590-5p FMOD 0.746515607868274 8.51300479640125e-09 -1.5830220066125 1.49258819797672e-21 miRanda -0.426306741203089 1.417924339406e-22 NA NA NA hsa-miR-7-1-3p FMOD 0.686579567507582 1.20731554448806e-07 -1.5830220066125 1.49258819797672e-21 mirMAP -0.27230637908464 8.31897074788991e-10 NA NA NA hsa-let-7g-5p FN1 0.0200025784917734 0.791635298815256 2.70001074183699 2.543883061007e-54 miRTarBase -0.225052184089239 0.0083113477930263 NA NA NA hsa-miR-1-3p FN1 -1.92761220689044 2.14541307073875e-29 2.70001074183699 2.543883061007e-54 miRTarBase;MirTarget -0.1494579156962 3.5893984502932e-05 NA NA NA hsa-miR-139-5p FN1 -3.25846663863766 2.62018989415003e-112 2.70001074183699 2.543883061007e-54 miRanda -0.510579303686055 6.29670431922458e-45 NA NA NA hsa-miR-193a-5p FN1 -1.1508321886378 7.11949564429669e-37 2.70001074183699 2.543883061007e-54 miRNATAP -0.201454473655291 0.00288108647203586 NA NA NA hsa-miR-217 FN1 -0.616728851115349 8.64977119332241e-05 2.70001074183699 2.543883061007e-54 MirTarget;PITA;miRanda -0.127242963083369 0.00168826238282668 NA NA NA hsa-miR-26b-5p FN1 -0.331527896896866 0.000551258576575092 2.70001074183699 2.543883061007e-54 miRNAWalker2_validate -0.298684140290862 7.00186998284315e-06 NA NA NA hsa-miR-27a-5p FN1 -1.23847974615121 1.26367431345318e-19 2.70001074183699 2.543883061007e-54 MirTarget -0.220835464335831 1.24127004151762e-06 NA NA NA hsa-miR-320a FN1 -0.287921276129346 0.00141693637596294 2.70001074183699 2.543883061007e-54 miRanda -0.339258614542988 1.62507196664897e-06 NA NA NA hsa-miR-511-5p FN1 -2.27545475897362 3.84085514050558e-36 2.70001074183699 2.543883061007e-54 MirTarget -0.10476429635028 0.00200343663280643 NA NA NA hsa-let-7a-3p FSTL1 0.466622567891891 3.70886257943079e-07 -1.28139008179553 1.01404950224375e-26 mirMAP -0.243225685297484 1.13489122527577e-07 NA NA NA hsa-miR-148a-5p FSTL1 0.572692271754695 2.14306251522796e-06 -1.28139008179553 1.01404950224375e-26 mirMAP -0.160555155131206 4.01411745780556e-06 NA NA NA hsa-miR-181a-5p FSTL1 0.635863607630183 6.72486918157744e-11 -1.28139008179553 1.01404950224375e-26 mirMAP -0.116486114159974 0.00703703243943183 NA NA NA hsa-miR-181b-5p FSTL1 1.22749257795094 1.21998198830919e-27 -1.28139008179553 1.01404950224375e-26 mirMAP -0.181901127855477 5.40024964867815e-07 NA NA NA hsa-miR-181c-5p FSTL1 0.574847839298605 4.51287502066478e-07 -1.28139008179553 1.01404950224375e-26 mirMAP -0.235766027160168 1.33875637171908e-10 NA NA NA hsa-miR-200b-3p FSTL1 2.11744072703209 1.66710572104191e-43 -1.28139008179553 1.01404950224375e-26 MirTarget;TargetScan -0.360497287154624 3.72936436031533e-48 NA NA NA hsa-miR-200c-3p FSTL1 2.07038651806183 6.84613386286599e-51 -1.28139008179553 1.01404950224375e-26 MirTarget -0.453998296697041 2.3449872421462e-65 NA NA NA hsa-miR-29a-5p FSTL1 0.334183773952055 0.00445137265870197 -1.28139008179553 1.01404950224375e-26 mirMAP -0.107266664768102 0.00304744364905081 NA NA NA hsa-miR-320b FSTL1 0.412787504747938 0.00113457276903985 -1.28139008179553 1.01404950224375e-26 miRanda -0.126659586345734 0.000158075702141383 NA NA NA hsa-miR-330-3p FSTL1 0.432728362037032 0.00041335506960812 -1.28139008179553 1.01404950224375e-26 mirMAP -0.138524625932451 7.44855715267788e-05 NA NA NA hsa-miR-429 FSTL1 2.84108892259147 3.88520896426515e-64 -1.28139008179553 1.01404950224375e-26 MirTarget;PITA;miRanda -0.295290167774316 5.67693174134047e-40 NA NA NA hsa-miR-590-3p FSTL1 1.27438512890514 1.03164723481469e-23 -1.28139008179553 1.01404950224375e-26 miRanda;mirMAP -0.253871425305642 3.49547610633251e-14 NA NA NA hsa-miR-7-1-3p FSTL1 0.686579567507582 1.20731554448806e-07 -1.28139008179553 1.01404950224375e-26 MirTarget -0.23067294025264 6.38569011613633e-13 NA NA NA hsa-miR-132-5p FSTL3 0.00856969271207952 0.943939962700181 -0.079932861869441 0.54304837070268 MirTarget -0.180011836259243 1.69973409378323e-06 NA NA NA hsa-miR-185-3p FSTL3 0.86591374114446 7.8790769678542e-10 -0.079932861869441 0.54304837070268 MirTarget -0.178140471131649 2.4747829526341e-08 NA NA NA hsa-miR-20a-3p FSTL3 -0.218902047543766 0.179868363625547 -0.079932861869441 0.54304837070268 mirMAP -0.292796206668169 8.25453473412079e-28 NA NA NA hsa-miR-491-5p FSTL3 -1.04307210952796 1.14586501470398e-15 -0.079932861869441 0.54304837070268 miRanda -0.107453038878017 0.00168880458589141 NA NA NA hsa-miR-766-3p FSTL3 0.496790679032227 8.22686414022553e-05 -0.079932861869441 0.54304837070268 mirMAP -0.314746233462925 1.66775253915131e-19 NA NA NA hsa-miR-9-5p FSTL3 0.734772328078424 0.00261982843636383 -0.079932861869441 0.54304837070268 miRNAWalker2_validate -0.167362195361962 1.13341264546396e-20 NA NA NA hsa-miR-361-5p FUCA1 -0.0996867547900457 0.095428250126326 0.109044210054368 0.185977765142224 miRanda -0.175985158570516 0.000241812952646412 NA NA NA hsa-miR-324-5p FZD8 0.211552647440779 0.139408130311654 -0.451402348278936 0.00210719128371962 miRanda -0.112580820578128 0.00139833151556216 NA NA NA hsa-miR-590-3p FZD8 1.27438512890514 1.03164723481469e-23 -0.451402348278936 0.00210719128371962 miRanda -0.187080083941158 3.36973671342903e-06 NA NA NA hsa-miR-7-1-3p FZD8 0.686579567507582 1.20731554448806e-07 -0.451402348278936 0.00210719128371962 MirTarget -0.285864089758394 6.15672183615667e-14 NA NA NA hsa-miR-99b-5p FZD8 0.286053025104474 0.0059164652978285 -0.451402348278936 0.00210719128371962 MirTarget -0.27167361740119 1.84979575053296e-08 NA NA NA hsa-miR-148b-3p GADD45A 1.0552576751879 1.6679285705231e-29 -0.208892067351644 0.0348101740051854 MirTarget -0.231496451348305 2.77073546077852e-11 NA NA NA hsa-miR-331-5p GADD45A 0.682437632502949 4.10871642662371e-11 -0.208892067351644 0.0348101740051854 PITA;miRNATAP -0.123517623290777 0.000150251086827537 NA NA NA hsa-miR-1976 GADD45B 0.289190368864725 0.00167092758216584 0.00189543029343842 0.986264142476403 miRNATAP -0.184077522593828 6.9983734252811e-06 NA NA NA hsa-miR-324-3p GADD45B 0.404877731996915 0.000340036423920834 0.00189543029343842 0.986264142476403 MirTarget;miRNATAP -0.272759607730261 8.22009676059255e-17 NA NA NA hsa-miR-590-3p GADD45B 1.27438512890514 1.03164723481469e-23 0.00189543029343842 0.986264142476403 miRanda -0.144434950089762 1.57603896644092e-06 NA NA NA hsa-let-7a-3p GAS1 0.466622567891891 3.70886257943079e-07 -1.65871668287995 1.94471293963436e-27 miRNATAP -0.302009963199178 2.59083006697777e-07 NA NA NA hsa-miR-130b-3p GAS1 1.38122163823846 1.00932179737836e-26 -1.65871668287995 1.94471293963436e-27 miRNAWalker2_validate -0.155462838569581 0.000141325580824666 NA NA NA hsa-miR-148a-3p GAS1 0.706969798912638 5.52538085480485e-09 -1.65871668287995 1.94471293963436e-27 miRNAWalker2_validate -0.178507927429249 5.50218154850598e-05 NA NA NA hsa-miR-183-5p GAS1 2.95681814393872 1.09965777344285e-92 -1.65871668287995 1.94471293963436e-27 miRNAWalker2_validate -0.419009244085051 8.34367517774905e-40 NA NA NA hsa-miR-193a-3p GAS1 0.310617999804917 0.00477640270974957 -1.65871668287995 1.94471293963436e-27 miRanda -0.241042574271965 8.97190960614992e-07 NA NA NA hsa-miR-33a-5p GAS1 1.35185127289399 9.80509199125785e-12 -1.65871668287995 1.94471293963436e-27 miRNATAP -0.142782362932409 1.71625141501421e-07 NA NA NA hsa-miR-625-5p GAS1 0.728939236913178 5.97591217674307e-08 -1.65871668287995 1.94471293963436e-27 MirTarget -0.320952346796682 2.98472195935842e-15 NA NA NA hsa-miR-141-3p GEM 2.99777540204168 1.26370498493024e-78 -1.31064474948309 3.35918949026588e-21 MirTarget -0.348552712353379 5.36878261091719e-40 NA NA NA hsa-miR-200a-3p GEM 2.55218480823434 2.96135446816238e-51 -1.31064474948309 3.35918949026588e-21 MirTarget -0.272868820275543 3.85481987191298e-25 NA NA NA hsa-miR-200b-3p GEM 2.11744072703209 1.66710572104191e-43 -1.31064474948309 3.35918949026588e-21 MirTarget -0.252352371736365 1.51025792341624e-17 NA NA NA hsa-miR-200c-3p GEM 2.07038651806183 6.84613386286599e-51 -1.31064474948309 3.35918949026588e-21 MirTarget;miRNATAP -0.335050212119271 2.44070410189031e-25 NA NA NA hsa-miR-429 GEM 2.84108892259147 3.88520896426515e-64 -1.31064474948309 3.35918949026588e-21 MirTarget;PITA;miRanda;miRNATAP -0.275192747833231 6.37478984026231e-26 NA NA NA hsa-miR-590-3p GEM 1.27438512890514 1.03164723481469e-23 -1.31064474948309 3.35918949026588e-21 miRanda -0.347226457548073 1.0789314936593e-19 NA NA NA hsa-miR-625-5p GEM 0.728939236913178 5.97591217674307e-08 -1.31064474948309 3.35918949026588e-21 MirTarget -0.162873532956131 1.10830204272588e-05 NA NA NA hsa-miR-130b-3p GJA1 1.38122163823846 1.00932179737836e-26 -0.194519922996644 0.269525778730357 MirTarget;miRNATAP -0.238621957319642 1.41329336820346e-07 NA NA NA hsa-miR-148a-5p GJA1 0.572692271754695 2.14306251522796e-06 -0.194519922996644 0.269525778730357 MirTarget;miRNATAP -0.138163624084416 0.0055107328924815 NA NA NA hsa-miR-17-5p GJA1 0.599531757298529 1.07318660415906e-05 -0.194519922996644 0.269525778730357 TargetScan -0.351682120604421 5.46480514907797e-16 NA NA NA hsa-miR-185-5p GJA1 0.482334746589337 3.68475879959415e-09 -0.194519922996644 0.269525778730357 MirTarget -0.397125823411858 5.84178037037683e-08 NA NA NA hsa-miR-186-5p GJA1 -0.426987301460247 1.04129380549315e-05 -0.194519922996644 0.269525778730357 MirTarget;miRNATAP -0.222252947787994 0.000354868900539435 NA NA NA hsa-miR-19a-3p GJA1 0.817507952171848 3.76285090469625e-08 -0.194519922996644 0.269525778730357 MirTarget;miRNATAP -0.280236129460921 1.9800173219761e-12 NA NA NA hsa-miR-19b-3p GJA1 0.139124391010031 0.255658553872934 -0.194519922996644 0.269525778730357 MirTarget;miRNATAP -0.311626473450612 1.97430883525218e-10 NA NA NA hsa-miR-301a-3p GJA1 1.32170168375632 2.12280368957514e-15 -0.194519922996644 0.269525778730357 MirTarget;miRNATAP -0.195311640602657 4.17560967627632e-08 NA NA NA hsa-miR-30d-3p GJA1 0.264544633563642 0.00755023189129747 -0.194519922996644 0.269525778730357 MirTarget -0.235751929896872 0.000113282620467275 NA NA NA hsa-miR-30d-5p GJA1 -0.247082219011045 0.00406717930063148 -0.194519922996644 0.269525778730357 MirTarget;mirMAP;miRNATAP -0.301458683465555 1.82056810341137e-05 NA NA NA hsa-miR-30e-5p GJA1 0.293491764699475 0.000372291967271834 -0.194519922996644 0.269525778730357 MirTarget -0.372557262609786 3.53423275353575e-07 NA NA NA hsa-miR-429 GJA1 2.84108892259147 3.88520896426515e-64 -0.194519922996644 0.269525778730357 miRanda;miRNATAP -0.13974473350262 2.64824504894479e-05 NA NA NA hsa-miR-454-3p GJA1 1.28177672191095 6.84024979484587e-21 -0.194519922996644 0.269525778730357 MirTarget;miRNATAP -0.155781613967644 0.000324429845168819 NA NA NA hsa-miR-455-5p GJA1 0.284641224662773 0.0357572339594277 -0.194519922996644 0.269525778730357 miRanda -0.159220787965387 0.000349015091067566 NA NA NA hsa-miR-576-5p GJA1 0.0649387707567879 0.588791966096287 -0.194519922996644 0.269525778730357 PITA;mirMAP -0.194494100441147 0.000110197419866725 NA NA NA hsa-miR-590-3p GJA1 1.27438512890514 1.03164723481469e-23 -0.194519922996644 0.269525778730357 PITA;miRanda -0.277015994273967 8.06917516240837e-09 NA NA NA hsa-miR-7-1-3p GJA1 0.686579567507582 1.20731554448806e-07 -0.194519922996644 0.269525778730357 mirMAP -0.138594120506321 0.00272628990646283 NA NA NA hsa-miR-107 GLIPR1 0.678998026350662 2.56224148930538e-16 -0.538944187501849 5.34994386945633e-08 miRanda -0.176884087584726 1.36747211251129e-05 NA NA NA hsa-miR-149-5p GLIPR1 0.218233101703391 0.261629158371175 -0.538944187501849 5.34994386945633e-08 MirTarget -0.116465318274217 2.19427568524189e-11 NA NA NA hsa-miR-30d-3p GLIPR1 0.264544633563642 0.00755023189129747 -0.538944187501849 5.34994386945633e-08 mirMAP -0.155146817742852 7.14205504878676e-06 NA NA NA hsa-miR-338-3p GLIPR1 0.0799903526884966 0.575137668326679 -0.538944187501849 5.34994386945633e-08 PITA;miRanda -0.131863941433941 3.22156201173289e-08 NA NA NA hsa-miR-324-3p GPC1 0.404877731996915 0.000340036423920834 0.71453412518615 8.91398991658802e-11 MirTarget -0.19231197967632 9.88633038528142e-09 NA NA NA hsa-miR-326 GPC1 -1.54449030848141 1.04703417845594e-17 0.71453412518615 8.91398991658802e-11 mirMAP -0.181075070669763 5.55218962927119e-19 NA NA NA hsa-miR-330-5p GPC1 0.626063225953928 3.42215028606779e-09 0.71453412518615 8.91398991658802e-11 mirMAP -0.189261285918291 1.08499820316535e-07 NA NA NA hsa-miR-339-5p GPC1 -0.211548290465418 0.0685885445822389 0.71453412518615 8.91398991658802e-11 mirMAP -0.111081192154153 0.00074168072088133 NA NA NA hsa-miR-484 GPC1 0.349444060004737 0.00154491249625173 0.71453412518615 8.91398991658802e-11 mirMAP -0.153708872214093 8.47019295949954e-06 NA NA NA hsa-let-7a-5p GPX7 -0.210286642041636 0.0072546234707717 0.120838177466512 0.294218647757274 miRNATAP -0.208978240416225 3.65111489353645e-05 NA NA NA hsa-let-7b-5p GPX7 -0.54215483448257 7.21347617597858e-08 0.120838177466512 0.294218647757274 miRNAWalker2_validate;miRNATAP -0.122667062880486 0.00167575740691661 NA NA NA hsa-miR-29b-3p GPX7 0.438847962603729 6.46722433236121e-05 0.120838177466512 0.294218647757274 MirTarget;miRNATAP -0.207346884213842 5.84025305757627e-09 NA NA NA hsa-miR-29c-3p GPX7 -0.0652732378039769 0.563774115756922 0.120838177466512 0.294218647757274 MirTarget;miRNATAP -0.322477139597712 4.08472190744314e-21 NA NA NA hsa-let-7a-3p GREM1 0.466622567891891 3.70886257943079e-07 0.931037098913743 4.48110163194541e-06 mirMAP -0.269393513108956 0.000393934611051038 NA NA NA hsa-miR-107 GREM1 0.678998026350662 2.56224148930538e-16 0.931037098913743 4.48110163194541e-06 miRanda -0.22709240993063 0.00649924406364985 NA NA NA hsa-miR-139-5p GREM1 -3.25846663863766 2.62018989415003e-112 0.931037098913743 4.48110163194541e-06 miRanda -0.232142309930125 2.63788130403564e-08 NA NA NA hsa-miR-186-5p GREM1 -0.426987301460247 1.04129380549315e-05 0.931037098913743 4.48110163194541e-06 mirMAP -0.237286486264099 0.00100652804870007 NA NA NA hsa-miR-30a-3p GREM1 -1.08956435286856 1.10750674569595e-12 0.931037098913743 4.48110163194541e-06 MirTarget -0.19803125761448 1.03877306124263e-05 NA NA NA hsa-miR-30d-3p GREM1 0.264544633563642 0.00755023189129747 0.931037098913743 4.48110163194541e-06 MirTarget -0.375049372911174 1.03484907095245e-07 NA NA NA hsa-miR-374a-5p GREM1 -0.239709888246804 0.00309819667153627 0.931037098913743 4.48110163194541e-06 mirMAP -0.240698616075552 0.00558840302059989 NA NA NA hsa-miR-664a-3p GREM1 -0.237699857923843 0.0197071390183375 0.931037098913743 4.48110163194541e-06 mirMAP -0.37727943609123 3.46728908893252e-08 NA NA NA hsa-miR-155-5p HTRA1 1.09766314984151 4.55650930885814e-15 -0.233343689265631 0.0665552050085431 miRNAWalker2_validate -0.146551179040103 1.53939177664393e-06 NA NA NA hsa-miR-16-5p HTRA1 0.46835991343556 1.91125356547776e-06 -0.233343689265631 0.0665552050085431 miRNAWalker2_validate -0.422013843013049 1.36740981509019e-22 NA NA NA hsa-miR-126-3p IGFBP2 -1.17432628002954 1.02041618253013e-20 0.596935721060786 0.00109631938043027 miRNAWalker2_validate;miRTarBase -0.239999056960138 7.76989976268351e-07 NA NA NA hsa-miR-130b-5p IGFBP2 1.0573161199584 2.55177349228739e-12 0.596935721060786 0.00109631938043027 MirTarget;miRNATAP -0.231289821474843 1.39834888370243e-08 NA NA NA hsa-miR-140-5p IGFBP2 -0.755971041589807 9.68060922934542e-14 0.596935721060786 0.00109631938043027 miRanda -0.406733662323868 1.79767000222464e-11 NA NA NA hsa-miR-326 IGFBP2 -1.54449030848141 1.04703417845594e-17 0.596935721060786 0.00109631938043027 miRanda -0.162441580565577 1.80363588568712e-06 NA NA NA hsa-miR-423-3p IGFBP2 0.338351552541003 0.000947983901628776 0.596935721060786 0.00109631938043027 PITA -0.162730045956905 0.00814522005984096 NA NA NA hsa-let-7a-3p IGFBP3 0.466622567891891 3.70886257943079e-07 -0.740251117224754 7.69399599791541e-12 miRNATAP -0.107092706207436 0.00877058958447313 NA NA NA hsa-miR-375 IGFBP3 2.09893673049766 1.68351780396203e-16 -0.740251117224754 7.69399599791541e-12 miRNAWalker2_validate -0.125007540214907 9.99564454514586e-19 NA NA NA hsa-miR-330-5p IGFBP4 0.626063225953928 3.42215028606779e-09 -0.178606757761465 0.137792555378636 MirTarget;miRanda -0.263961719934138 5.14042599641524e-12 NA NA NA hsa-miR-532-3p IGFBP4 -0.395473145042459 0.00686714288452761 -0.178606757761465 0.137792555378636 miRNATAP -0.298249125380108 7.37042770476075e-28 NA NA NA hsa-miR-582-3p IGFBP4 0.126152488945932 0.333088461939587 -0.178606757761465 0.137792555378636 PITA;miRNATAP -0.20885673667284 2.75365802625844e-11 NA NA NA hsa-miR-107 IL6 0.678998026350662 2.56224148930538e-16 -3.07751927232311 9.9131162785608e-32 miRanda -0.335195787804263 0.00267549740903922 NA NA NA hsa-miR-429 IL6 2.84108892259147 3.88520896426515e-64 -3.07751927232311 9.9131162785608e-32 miRanda -0.424185146928772 6.81793191441461e-17 NA NA NA hsa-miR-10b-5p INHBA -2.10996264627796 7.36811595736367e-72 2.92269165168259 7.0734436456195e-54 miRNAWalker2_validate -0.315991143995102 3.56059166646068e-09 NA NA NA hsa-miR-125b-2-3p INHBA -1.92374904783012 2.30779527653582e-38 2.92269165168259 7.0734436456195e-54 mirMAP -0.192569276917189 1.45917212337729e-05 NA NA NA hsa-miR-126-5p INHBA -1.27745588751177 2.96000918537631e-30 2.92269165168259 7.0734436456195e-54 mirMAP -0.365446042383557 8.00635434475456e-10 NA NA NA hsa-miR-195-3p INHBA -1.49582726452416 6.53261924105147e-40 2.92269165168259 7.0734436456195e-54 mirMAP -0.457507775640633 2.0024779119854e-15 NA NA NA hsa-miR-26a-5p INHBA -0.481180084102235 1.82368246174758e-10 2.92269165168259 7.0734436456195e-54 mirMAP -0.806583685372971 2.83412051156283e-19 NA NA NA hsa-miR-26b-5p INHBA -0.331527896896866 0.000551258576575092 2.92269165168259 7.0734436456195e-54 mirMAP -0.386714706799185 7.94265255522648e-08 NA NA NA hsa-miR-30a-5p INHBA -0.392489994825279 0.00954894667761676 2.92269165168259 7.0734436456195e-54 mirMAP -0.339337086240446 5.62802453652228e-14 NA NA NA hsa-miR-30b-5p INHBA -0.46540603860146 2.4709940429591e-05 2.92269165168259 7.0734436456195e-54 mirMAP -0.488363240944963 2.76553416939545e-15 NA NA NA hsa-miR-30c-5p INHBA -0.393222674580066 8.06961465717306e-05 2.92269165168259 7.0734436456195e-54 mirMAP -0.554034099183663 5.80415262756076e-16 NA NA NA hsa-miR-30d-5p INHBA -0.247082219011045 0.00406717930063148 2.92269165168259 7.0734436456195e-54 mirMAP -0.560261794318746 2.73850414996811e-12 NA NA NA hsa-miR-335-3p INHBA -1.88448538773649 2.09538234398335e-32 2.92269165168259 7.0734436456195e-54 mirMAP -0.358331308407745 2.90058922815416e-18 NA NA NA hsa-miR-374a-5p INHBA -0.239709888246804 0.00309819667153627 2.92269165168259 7.0734436456195e-54 mirMAP -0.501460291948885 4.49896836409766e-09 NA NA NA hsa-miR-374b-5p INHBA -0.466781429946153 1.17238311619116e-08 2.92269165168259 7.0734436456195e-54 mirMAP -0.423669398924089 4.99022706092223e-07 NA NA NA hsa-miR-664a-3p INHBA -0.237699857923843 0.0197071390183375 2.92269165168259 7.0734436456195e-54 mirMAP -0.329267118225509 1.28384451198929e-06 NA NA NA hsa-miR-103a-3p ITGA2 0.610673390034345 1.63113920514646e-12 -0.578073454534045 0.000245362336210971 miRNAWalker2_validate;MirTarget;miRNATAP -0.518553557094713 2.0689176307065e-17 NA NA NA hsa-miR-107 ITGA2 0.678998026350662 2.56224148930538e-16 -0.578073454534045 0.000245362336210971 MirTarget;miRanda;miRNATAP -0.578298559534823 5.92643308700432e-20 NA NA NA hsa-miR-130b-3p ITGA2 1.38122163823846 1.00932179737836e-26 -0.578073454534045 0.000245362336210971 mirMAP -0.290892177898957 6.18833747120119e-13 NA NA NA hsa-miR-15a-5p ITGA2 0.812445324157528 4.50263417099822e-20 -0.578073454534045 0.000245362336210971 MirTarget;miRNATAP -0.571710856591226 1.80311916315964e-22 NA NA NA hsa-miR-15b-5p ITGA2 0.788659356634696 1.13678211092534e-11 -0.578073454534045 0.000245362336210971 MirTarget;miRNATAP -0.380913533105479 4.41835184495374e-17 NA NA NA hsa-miR-16-5p ITGA2 0.46835991343556 1.91125356547776e-06 -0.578073454534045 0.000245362336210971 miRNAWalker2_validate;MirTarget;miRNATAP -0.242009742873415 1.02794727566796e-05 NA NA NA hsa-miR-181a-5p ITGA2 0.635863607630183 6.72486918157744e-11 -0.578073454534045 0.000245362336210971 MirTarget -0.205880789895555 0.000189169212142989 NA NA NA hsa-miR-181b-5p ITGA2 1.22749257795094 1.21998198830919e-27 -0.578073454534045 0.000245362336210971 MirTarget -0.22966433200823 7.49310977501828e-07 NA NA NA hsa-miR-185-5p ITGA2 0.482334746589337 3.68475879959415e-09 -0.578073454534045 0.000245362336210971 miRNATAP -0.711126708939395 1.04319804229734e-28 NA NA NA hsa-miR-18a-5p ITGA2 0.969066793715868 1.69069796425892e-08 -0.578073454534045 0.000245362336210971 MirTarget -0.277288585922338 1.4587093955565e-19 NA NA NA hsa-miR-19a-3p ITGA2 0.817507952171848 3.76285090469625e-08 -0.578073454534045 0.000245362336210971 MirTarget -0.183101395943965 3.69579697317755e-07 NA NA NA hsa-miR-19b-3p ITGA2 0.139124391010031 0.255658553872934 -0.578073454534045 0.000245362336210971 MirTarget -0.158712773707016 0.00034384673625258 NA NA NA hsa-miR-27a-3p ITGA2 0.388496361379095 1.42373532086331e-05 -0.578073454534045 0.000245362336210971 miRNATAP -0.191806915756419 0.00155051571375338 NA NA NA hsa-miR-301a-3p ITGA2 1.32170168375632 2.12280368957514e-15 -0.578073454534045 0.000245362336210971 mirMAP -0.166685535121401 1.92153514631417e-07 NA NA NA hsa-miR-30e-5p ITGA2 0.293491764699475 0.000372291967271834 -0.578073454534045 0.000245362336210971 mirMAP -0.174823441914395 0.00813656907618175 NA NA NA hsa-miR-324-5p ITGA2 0.211552647440779 0.139408130311654 -0.578073454534045 0.000245362336210971 miRanda -0.136513885303923 0.000310229032135042 NA NA NA hsa-miR-330-5p ITGA2 0.626063225953928 3.42215028606779e-09 -0.578073454534045 0.000245362336210971 PITA -0.136903008445456 0.0071300294329751 NA NA NA hsa-miR-340-5p ITGA2 1.0857159627596 4.94471062546756e-24 -0.578073454534045 0.000245362336210971 mirMAP -0.398174029476505 1.84496145385471e-16 NA NA NA hsa-miR-374a-5p ITGA2 -0.239709888246804 0.00309819667153627 -0.578073454534045 0.000245362336210971 MirTarget -0.315553562871544 2.50089061582709e-06 NA NA NA hsa-miR-374b-5p ITGA2 -0.466781429946153 1.17238311619116e-08 -0.578073454534045 0.000245362336210971 MirTarget -0.273064428324435 3.50223913512016e-05 NA NA NA hsa-miR-454-3p ITGA2 1.28177672191095 6.84024979484587e-21 -0.578073454534045 0.000245362336210971 mirMAP -0.188214261131704 1.22159793880003e-06 NA NA NA hsa-miR-532-5p ITGA2 0.0386976222860582 0.682018574136515 -0.578073454534045 0.000245362336210971 MirTarget -0.308713851602447 7.4391196813151e-08 NA NA NA hsa-miR-590-3p ITGA2 1.27438512890514 1.03164723481469e-23 -0.578073454534045 0.000245362336210971 MirTarget;miRanda;mirMAP -0.266166940907233 6.42250404215377e-10 NA NA NA hsa-miR-590-5p ITGA2 0.746515607868274 8.51300479640125e-09 -0.578073454534045 0.000245362336210971 miRanda -0.245731794950449 2.43759428268426e-09 NA NA NA hsa-miR-93-3p ITGA2 0.627759242044891 3.62527588304617e-06 -0.578073454534045 0.000245362336210971 MirTarget -0.122698897518948 0.00205245997033807 NA NA NA hsa-miR-148b-3p ITGA5 1.0552576751879 1.6679285705231e-29 0.258471542303731 0.00349408854059877 miRNAWalker2_validate -0.122356058603336 9.68208950992594e-05 27328731 Notably transendothelial migration in vitro and extravasation in vivo impaired by singly alternating miR-214 or miR-148b could be overridden by overexpression of ITGA5 or ALCAM in the same tumor cells melanoma hsa-miR-25-3p ITGA5 -0.00546790775985073 0.944061771389468 0.258471542303731 0.00349408854059877 miRNATAP -0.133075462333109 0.000708776724292318 NA NA NA hsa-miR-26a-5p ITGA5 -0.481180084102235 1.82368246174758e-10 0.258471542303731 0.00349408854059877 miRNATAP -0.131306000973994 0.0010672095572809 25537511 Furthermore we provide experimental evidence to confirm that ITGA5 is a bona fide target of miR-26a liver cancer hsa-miR-26b-5p ITGA5 -0.331527896896866 0.000551258576575092 0.258471542303731 0.00349408854059877 miRNATAP -0.104503299205837 0.000970956331959348 NA NA NA hsa-miR-30a-5p ITGA5 -0.392489994825279 0.00954894667761676 0.258471542303731 0.00349408854059877 miRNATAP -0.126371446171278 1.90284369217649e-10 NA NA NA hsa-miR-30c-5p ITGA5 -0.393222674580066 8.06961465717306e-05 0.258471542303731 0.00349408854059877 miRNATAP -0.222941024449013 1.1526773250089e-13 NA NA NA hsa-miR-30d-5p ITGA5 -0.247082219011045 0.00406717930063148 0.258471542303731 0.00349408854059877 miRNATAP -0.329430073488982 1.88892816446792e-21 NA NA NA hsa-miR-92a-3p ITGA5 -0.342420481092807 0.000732275969501111 0.258471542303731 0.00349408854059877 miRNAWalker2_validate;miRTarBase;miRNATAP -0.14127429191828 2.23941319844575e-06 23499550 The level of miR-92a expression was significantly inversely correlated with ITGA5 expression in various cancer cells; miR-92a overexpression reduced the luciferase activity of the ITGA5 3'-untranslated region suggesting that ITGA5 mRNA is a direct target of miR-92a ovarian cancer hsa-miR-141-3p ITGAV 2.99777540204168 1.26370498493024e-78 -0.0515028444394998 0.572303431365019 MirTarget -0.108251623223024 6.82325620061394e-10 NA NA NA hsa-miR-146b-5p ITGAV 0.631041661167954 6.20366593452965e-08 -0.0515028444394998 0.572303431365019 miRNATAP -0.130383265663822 8.70537168422505e-07 NA NA NA hsa-miR-16-2-3p ITGAV 0.286355254959005 0.0256946046884474 -0.0515028444394998 0.572303431365019 mirMAP -0.114151130652451 2.89132415975006e-06 NA NA NA hsa-miR-200a-3p ITGAV 2.55218480823434 2.96135446816238e-51 -0.0515028444394998 0.572303431365019 MirTarget -0.10013577528264 6.24202667621143e-09 NA NA NA hsa-miR-25-3p ITGAV -0.00546790775985073 0.944061771389468 -0.0515028444394998 0.572303431365019 MirTarget;miRNATAP -0.370376073430225 7.01243332686135e-21 NA NA NA hsa-miR-32-5p ITGAV 1.38676603945192 2.29428299685976e-34 -0.0515028444394998 0.572303431365019 miRNAWalker2_validate;MirTarget;miRNATAP -0.156084602649262 2.65782272596475e-09 NA NA NA hsa-miR-340-5p ITGAV 1.0857159627596 4.94471062546756e-24 -0.0515028444394998 0.572303431365019 MirTarget -0.200546887202324 7.77472998675104e-13 NA NA NA hsa-miR-361-5p ITGAV -0.0996867547900457 0.095428250126326 -0.0515028444394998 0.572303431365019 MirTarget;miRanda -0.446958137818793 9.60789577977041e-18 NA NA NA hsa-miR-374a-5p ITGAV -0.239709888246804 0.00309819667153627 -0.0515028444394998 0.572303431365019 mirMAP -0.196885558896755 3.2752597700007e-07 NA NA NA hsa-miR-374b-5p ITGAV -0.466781429946153 1.17238311619116e-08 -0.0515028444394998 0.572303431365019 mirMAP -0.170952398660091 6.70571303305635e-06 NA NA NA hsa-miR-429 ITGAV 2.84108892259147 3.88520896426515e-64 -0.0515028444394998 0.572303431365019 miRanda -0.104635159336959 9.38637410830064e-10 NA NA NA hsa-miR-590-3p ITGAV 1.27438512890514 1.03164723481469e-23 -0.0515028444394998 0.572303431365019 MirTarget;PITA;miRanda -0.119529282212692 1.60610663897823e-06 NA NA NA hsa-miR-92a-3p ITGAV -0.342420481092807 0.000732275969501111 -0.0515028444394998 0.572303431365019 MirTarget;miRNATAP -0.195743851357691 1.45632172375267e-10 NA NA NA hsa-miR-29b-3p ITGB1 0.438847962603729 6.46722433236121e-05 -0.678317106156189 5.66194666134702e-21 MirTarget;miRNATAP -0.152257153554482 2.41999128688943e-11 NA NA NA hsa-miR-29c-3p ITGB1 -0.0652732378039769 0.563774115756922 -0.678317106156189 5.66194666134702e-21 MirTarget;miRNATAP -0.247090129124282 4.86511208246984e-30 26766915 MiR 29c inhibits cell growth invasion and migration of pancreatic cancer by targeting ITGB1; Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c and knockdown of ITGB1 inhibited the proliferation migration and invasion of PC cells which was similar to the effects of overexpression of miR-29c pancreatic cancer hsa-miR-429 ITGB1 2.84108892259147 3.88520896426515e-64 -0.678317106156189 5.66194666134702e-21 miRanda -0.133174997661172 1.66767130152533e-22 NA NA NA hsa-let-7d-5p ITGB3 0.410958462607207 6.07808182756787e-06 -1.34505322338581 2.68734688128446e-18 MirTarget -0.226787731014433 0.00013304304139482 NA NA NA hsa-miR-146b-5p ITGB3 0.631041661167954 6.20366593452965e-08 -1.34505322338581 2.68734688128446e-18 miRanda -0.153799435346728 0.000833490792102149 NA NA NA hsa-miR-185-5p ITGB3 0.482334746589337 3.68475879959415e-09 -1.34505322338581 2.68734688128446e-18 MirTarget -0.304965495253094 3.39457628789725e-06 NA NA NA hsa-miR-30b-5p ITGB3 -0.46540603860146 2.4709940429591e-05 -1.34505322338581 2.68734688128446e-18 mirMAP -0.204346006917438 2.74563362212737e-05 20498642 Enforced constitutive expression of mir-30 in BT-ICs inhibits their self-renewal capacity by reducing Ubc9 and induces apoptosis through silencing ITGB3 breast cancer hsa-miR-30d-5p ITGB3 -0.247082219011045 0.00406717930063148 -1.34505322338581 2.68734688128446e-18 miRNATAP -0.250653743046726 6.86760348205262e-05 NA NA NA hsa-miR-320b ITGB3 0.412787504747938 0.00113457276903985 -1.34505322338581 2.68734688128446e-18 miRanda -0.153816296240077 0.000316895415818085 NA NA NA hsa-miR-425-5p ITGB3 0.719898949241718 6.01079610190374e-08 -1.34505322338581 2.68734688128446e-18 MirTarget -0.161987450170202 5.78628325273088e-05 NA NA NA hsa-miR-429 ITGB3 2.84108892259147 3.88520896426515e-64 -1.34505322338581 2.68734688128446e-18 miRanda -0.310603398492102 6.39753034365381e-27 NA NA NA hsa-miR-589-5p ITGB3 0.367182541239722 1.67804815542873e-05 -1.34505322338581 2.68734688128446e-18 MirTarget -0.276791248608563 1.19994930769854e-05 NA NA NA hsa-miR-590-3p ITGB3 1.27438512890514 1.03164723481469e-23 -1.34505322338581 2.68734688128446e-18 PITA;miRanda -0.288689456241701 1.55218406303079e-11 NA NA NA hsa-miR-590-5p ITGB3 0.746515607868274 8.51300479640125e-09 -1.34505322338581 2.68734688128446e-18 miRanda -0.246206813772265 1.96120756746322e-09 NA NA NA hsa-miR-98-5p ITGB3 0.656336869298973 9.03113188590466e-15 -1.34505322338581 2.68734688128446e-18 miRNAWalker2_validate;MirTarget -0.411301106439792 4.66935458245862e-11 26445551 miR 98 targets ITGB3 to inhibit proliferation migration and invasion of non small cell lung cancer; Furthermore we identified that miR-98 exerted inhibitory roles by directly binding to 3'-UTR of ITGB3 mRNA thus negatively regulated the expression of ITGB3; Interestingly upon restoring the expression of ITGB3 the effect of miR-98 on cell proliferation was partially reversed; Our findings suggest that miR-98 prevents proliferation migration and invasion of lung cancer cells by directly binding to the 3'-UTR of ITGB3 mRNA and could be a promising treatment option in anticancer therapy lung squamous cell cancer hsa-miR-155-5p ITGB5 1.09766314984151 4.55650930885814e-15 0.194292620009985 0.0495928541847793 miRNAWalker2_validate -0.22825351522107 8.103079189556e-23 NA NA NA hsa-miR-361-5p ITGB5 -0.0996867547900457 0.095428250126326 0.194292620009985 0.0495928541847793 miRanda -0.1559317416226 0.00689088652431586 NA NA NA hsa-miR-378a-5p ITGB5 -2.43173551693523 1.44932837789175e-68 0.194292620009985 0.0495928541847793 MirTarget -0.136596769908688 7.57897389611419e-10 NA NA NA hsa-miR-484 ITGB5 0.349444060004737 0.00154491249625173 0.194292620009985 0.0495928541847793 miRNATAP -0.21252315870238 2.65861108593946e-12 NA NA NA hsa-miR-141-3p JUN 2.99777540204168 1.26370498493024e-78 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.26513026030347 4.33514873445987e-29 NA NA NA hsa-miR-155-5p JUN 1.09766314984151 4.55650930885814e-15 -1.36309173493779 4.05020743854001e-29 miRNAWalker2_validate;miRTarBase -0.151050894850655 5.76726631886013e-07 23693020 In the present study we demonstrated for the first time that activation of RAGE by S100P regulates oncogenic microRNA-155 miR-155 expression through Activator Protein-1 AP-1 stimulation in colon cancer cells colon cancer hsa-miR-16-5p JUN 0.46835991343556 1.91125356547776e-06 -1.36309173493779 4.05020743854001e-29 miRNAWalker2_validate -0.336111932326481 7.47849859844435e-15 NA NA NA hsa-miR-200a-3p JUN 2.55218480823434 2.96135446816238e-51 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.179081800592841 4.16743748553287e-14 NA NA NA hsa-miR-200b-3p JUN 2.11744072703209 1.66710572104191e-43 -1.36309173493779 4.05020743854001e-29 MirTarget;TargetScan -0.16460620647419 5.28647088864828e-10 NA NA NA hsa-miR-200c-3p JUN 2.07038651806183 6.84613386286599e-51 -1.36309173493779 4.05020743854001e-29 MirTarget -0.273188681953389 1.78966606345752e-21 NA NA NA hsa-miR-32-5p JUN 1.38676603945192 2.29428299685976e-34 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.263951179853313 2.73587232573327e-13 NA NA NA hsa-miR-342-3p JUN 1.21944481975657 6.81914373001202e-19 -1.36309173493779 4.05020743854001e-29 miRNAWalker2_validate -0.199604605467411 5.91888161762324e-11 NA NA NA hsa-miR-429 JUN 2.84108892259147 3.88520896426515e-64 -1.36309173493779 4.05020743854001e-29 MirTarget;PITA;miRanda;miRNATAP -0.17100165827497 4.02284319393828e-13 NA NA NA hsa-miR-455-3p JUN 0.678392920628872 0.000327758844555877 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.147720631567845 5.98195601818343e-11 NA NA NA hsa-miR-590-3p JUN 1.27438512890514 1.03164723481469e-23 -1.36309173493779 4.05020743854001e-29 miRanda -0.306481168731635 1.59764946185952e-19 NA NA NA hsa-miR-92a-3p JUN -0.342420481092807 0.000732275969501111 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.138285339206201 0.00119119178853874 NA NA NA hsa-miR-92b-3p JUN 1.30248132773644 9.42428674470985e-25 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.135248670230231 4.27496884553493e-05 NA NA NA hsa-miR-93-5p JUN 1.01788600209314 1.24312921618126e-21 -1.36309173493779 4.05020743854001e-29 miRNAWalker2_validate -0.216264935663652 4.08318210776355e-08 NA NA NA hsa-miR-342-3p LAMA1 1.21944481975657 6.81914373001202e-19 -1.41719202732824 1.99645859303e-12 miRanda -0.373365420839019 3.17298377107165e-14 NA NA NA hsa-miR-146b-5p LAMA2 0.631041661167954 6.20366593452965e-08 -2.16756236589159 1.88679943487983e-31 miRanda -0.179973081651138 0.00143455201383938 NA NA NA hsa-miR-375 LAMA2 2.09893673049766 1.68351780396203e-16 -2.16756236589159 1.88679943487983e-31 miRanda -0.141366224796711 2.30583404419529e-08 NA NA NA hsa-miR-590-3p LAMA2 1.27438512890514 1.03164723481469e-23 -2.16756236589159 1.88679943487983e-31 miRanda -0.585831805457993 2.67005129674139e-30 NA NA NA hsa-miR-17-5p LAMA3 0.599531757298529 1.07318660415906e-05 -2.53251208906831 2.18425216006227e-32 TargetScan -0.410037720264012 9.13613581227756e-14 NA NA NA hsa-miR-181a-5p LAMA3 0.635863607630183 6.72486918157744e-11 -2.53251208906831 2.18425216006227e-32 miRNAWalker2_validate -0.515885630770767 1.96293779720287e-11 NA NA NA hsa-miR-590-3p LAMA3 1.27438512890514 1.03164723481469e-23 -2.53251208906831 2.18425216006227e-32 miRanda -0.514039700190172 1.03861305236823e-17 NA NA NA hsa-miR-107 LAMC1 0.678998026350662 2.56224148930538e-16 -1.22673201326814 1.35102621663939e-35 miRanda -0.257698330142802 6.41811392129414e-10 NA NA NA hsa-miR-15a-5p LAMC1 0.812445324157528 4.50263417099822e-20 -1.22673201326814 1.35102621663939e-35 MirTarget -0.326629832851419 1.81370836508136e-17 NA NA NA hsa-miR-15b-5p LAMC1 0.788659356634696 1.13678211092534e-11 -1.22673201326814 1.35102621663939e-35 MirTarget -0.106501584548076 0.000387350984312645 NA NA NA hsa-miR-182-5p LAMC1 2.36408084103818 2.60011457600281e-72 -1.22673201326814 1.35102621663939e-35 miRNATAP -0.279210293932062 2.59063689304366e-32 NA NA NA hsa-miR-193a-3p LAMC1 0.310617999804917 0.00477640270974957 -1.22673201326814 1.35102621663939e-35 MirTarget;PITA;miRanda -0.114858064497944 0.000338849778603983 NA NA NA hsa-miR-200b-3p LAMC1 2.11744072703209 1.66710572104191e-43 -1.22673201326814 1.35102621663939e-35 MirTarget;TargetScan -0.289967230006364 9.75181041203852e-45 NA NA NA hsa-miR-200c-3p LAMC1 2.07038651806183 6.84613386286599e-51 -1.22673201326814 1.35102621663939e-35 MirTarget;miRNATAP -0.329360689529761 5.25538223517216e-48 NA NA NA hsa-miR-29b-3p LAMC1 0.438847962603729 6.46722433236121e-05 -1.22673201326814 1.35102621663939e-35 MirTarget;miRNATAP -0.26005932104654 1.6052896437976e-16 NA NA NA hsa-miR-29c-3p LAMC1 -0.0652732378039769 0.563774115756922 -1.22673201326814 1.35102621663939e-35 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.293087073092568 8.3737259345595e-22 NA NA NA hsa-miR-338-3p LAMC1 0.0799903526884966 0.575137668326679 -1.22673201326814 1.35102621663939e-35 MirTarget;miRanda -0.109223045761013 9.54907872319034e-06 NA NA NA hsa-miR-429 LAMC1 2.84108892259147 3.88520896426515e-64 -1.22673201326814 1.35102621663939e-35 MirTarget;PITA;miRanda;miRNATAP -0.250412580267939 1.24821064577774e-41 NA NA NA hsa-miR-590-3p LAMC1 1.27438512890514 1.03164723481469e-23 -1.22673201326814 1.35102621663939e-35 PITA;miRanda;mirMAP -0.173527924429224 5.97096955178295e-10 NA NA NA hsa-miR-96-5p LAMC1 3.24596558166606 1.92296159041707e-98 -1.22673201326814 1.35102621663939e-35 MirTarget;TargetScan;miRNATAP -0.258001814246817 1.73137300974635e-40 NA NA NA hsa-miR-98-5p LAMC1 0.656336869298973 9.03113188590466e-15 -1.22673201326814 1.35102621663939e-35 miRNAWalker2_validate -0.166984209258336 4.95571574796494e-05 NA NA NA hsa-miR-148b-3p LAMC2 1.0552576751879 1.6679285705231e-29 -1.62034326586173 2.05014148904585e-12 miRNAWalker2_validate -0.468080437420498 1.33999489210089e-08 NA NA NA hsa-miR-193a-3p LAMC2 0.310617999804917 0.00477640270974957 -1.62034326586173 2.05014148904585e-12 MirTarget;PITA;miRanda;miRNATAP -0.373136854988213 2.63946875891495e-07 NA NA NA hsa-miR-193b-3p LAMC2 -0.0550374855074773 0.65382485898551 -1.62034326586173 2.05014148904585e-12 MirTarget;miRNATAP -0.210485711342769 0.00129019619433589 NA NA NA hsa-miR-3065-3p LAMC2 1.62787885002468 6.81477830005026e-19 -1.62034326586173 2.05014148904585e-12 miRNATAP -0.126910675281551 0.00295289352008255 NA NA NA hsa-miR-338-3p LAMC2 0.0799903526884966 0.575137668326679 -1.62034326586173 2.05014148904585e-12 miRanda -0.191701598436574 0.000640679213604702 NA NA NA hsa-miR-342-3p LAMC2 1.21944481975657 6.81914373001202e-19 -1.62034326586173 2.05014148904585e-12 miRanda -0.273518493093315 1.49370659196398e-06 NA NA NA hsa-miR-375 LAMC2 2.09893673049766 1.68351780396203e-16 -1.62034326586173 2.05014148904585e-12 miRanda -0.225853976513003 1.07683110051097e-13 NA NA NA hsa-miR-107 LOX 0.678998026350662 2.56224148930538e-16 -0.342212996476533 0.0205578562983786 miRanda -0.311413855445394 2.21649668329811e-07 NA NA NA hsa-miR-181c-5p LOX 0.574847839298605 4.51287502066478e-07 -0.342212996476533 0.0205578562983786 miRNATAP -0.210908776404495 1.75135974961981e-06 NA NA NA hsa-miR-200b-3p LOX 2.11744072703209 1.66710572104191e-43 -0.342212996476533 0.0205578562983786 TargetScan -0.302299111361363 4.30683884623164e-23 NA NA NA hsa-miR-26a-5p LOX -0.481180084102235 1.82368246174758e-10 -0.342212996476533 0.0205578562983786 mirMAP -0.247703063019446 0.000214954846725891 NA NA NA hsa-miR-26b-5p LOX -0.331527896896866 0.000551258576575092 -0.342212996476533 0.0205578562983786 mirMAP -0.196176845475276 0.000205194308284124 NA NA NA hsa-miR-29a-3p LOX -0.699539666833076 1.13935003139957e-13 -0.342212996476533 0.0205578562983786 miRNATAP -0.194040534406761 0.000261828253281154 25153510 Second the direct interaction between one of the upregulated mRNA target the LOX gene which is an EMT key player and a downregulated miRNA the miR-29a was experimentally validated by a luciferase assay in HEK cell thyroid cancer hsa-miR-29b-3p LOX 0.438847962603729 6.46722433236121e-05 -0.342212996476533 0.0205578562983786 miRNATAP -0.45727722629628 1.97078782249483e-24 NA NA NA hsa-miR-29c-3p LOX -0.0652732378039769 0.563774115756922 -0.342212996476533 0.0205578562983786 miRNATAP -0.501491729796723 6.17341757637409e-31 NA NA NA hsa-miR-3065-3p LOX 1.62787885002468 6.81477830005026e-19 -0.342212996476533 0.0205578562983786 miRNATAP -0.176641057355417 3.94027128029485e-11 NA NA NA hsa-miR-30a-5p LOX -0.392489994825279 0.00954894667761676 -0.342212996476533 0.0205578562983786 miRNATAP -0.228474636102838 4.77976842693527e-12 NA NA NA hsa-miR-30c-5p LOX -0.393222674580066 8.06961465717306e-05 -0.342212996476533 0.0205578562983786 miRNATAP -0.331276969727424 4.59513320140804e-11 NA NA NA hsa-miR-30d-5p LOX -0.247082219011045 0.00406717930063148 -0.342212996476533 0.0205578562983786 miRNATAP -0.444905989841719 2.50338385132741e-14 NA NA NA hsa-miR-361-5p LOX -0.0996867547900457 0.095428250126326 -0.342212996476533 0.0205578562983786 miRanda;mirMAP -0.272717528809285 0.00155562487093774 NA NA NA hsa-miR-429 LOX 2.84108892259147 3.88520896426515e-64 -0.342212996476533 0.0205578562983786 miRanda;miRNATAP -0.222414643156444 6.65145132416868e-16 NA NA NA hsa-miR-590-3p LOX 1.27438512890514 1.03164723481469e-23 -0.342212996476533 0.0205578562983786 miRanda;mirMAP -0.169316428924958 2.93298636407417e-05 NA NA NA hsa-miR-664a-3p LOX -0.237699857923843 0.0197071390183375 -0.342212996476533 0.0205578562983786 mirMAP -0.231352664479899 3.21993588576158e-06 NA NA NA hsa-miR-125a-5p LOXL1 -0.635694700253268 3.6703235721638e-11 1.49728597567933 5.44851508051121e-34 PITA;miRanda;miRNATAP -0.257835924138673 1.14989628185356e-08 NA NA NA hsa-miR-132-3p LOXL1 -0.0365213889238607 0.668598301088667 1.49728597567933 5.44851508051121e-34 miRNAWalker2_validate -0.143121659688974 0.00594006063295867 NA NA NA hsa-miR-148b-3p LOXL1 1.0552576751879 1.6679285705231e-29 1.49728597567933 5.44851508051121e-34 miRNAWalker2_validate -0.186939744095812 3.98392737863584e-05 NA NA NA hsa-miR-335-5p LOXL1 -2.61355235628987 2.6462884165886e-51 1.49728597567933 5.44851508051121e-34 miRNAWalker2_validate -0.190396935804745 4.84447831217183e-16 NA NA NA hsa-miR-93-5p LOXL1 1.01788600209314 1.24312921618126e-21 1.49728597567933 5.44851508051121e-34 miRNAWalker2_validate -0.107749530846955 0.00769124817706178 NA NA NA hsa-miR-338-3p LOXL2 0.0799903526884966 0.575137668326679 0.452633522905841 0.00016238170789729 miRanda -0.126431466949616 1.18626595870113e-05 NA NA NA hsa-miR-107 LRP1 0.678998026350662 2.56224148930538e-16 -1.59623069924697 7.26581692175772e-39 PITA;miRNATAP -0.384781740071983 1.1000097853188e-13 NA NA NA hsa-miR-185-3p LRP1 0.86591374114446 7.8790769678542e-10 -1.59623069924697 7.26581692175772e-39 MirTarget -0.189841218797099 1.18110391941839e-09 NA NA NA hsa-miR-200b-3p LRP1 2.11744072703209 1.66710572104191e-43 -1.59623069924697 7.26581692175772e-39 TargetScan -0.390913060990931 5.87625867888281e-53 NA NA NA hsa-miR-324-5p LRP1 0.211552647440779 0.139408130311654 -1.59623069924697 7.26581692175772e-39 miRanda -0.221897143907922 2.83430871997104e-13 NA NA NA hsa-miR-339-5p LRP1 -0.211548290465418 0.0685885445822389 -1.59623069924697 7.26581692175772e-39 miRanda -0.195328595269352 2.35885565520623e-07 NA NA NA hsa-miR-342-3p LRP1 1.21944481975657 6.81914373001202e-19 -1.59623069924697 7.26581692175772e-39 miRanda -0.274836758894351 3.78967010501527e-19 NA NA NA hsa-miR-429 LRP1 2.84108892259147 3.88520896426515e-64 -1.59623069924697 7.26581692175772e-39 PITA;miRanda;miRNATAP -0.354221946366701 1.0201391252e-54 NA NA NA hsa-miR-590-3p LRP1 1.27438512890514 1.03164723481469e-23 -1.59623069924697 7.26581692175772e-39 PITA;miRanda;miRNATAP -0.427630964673263 9.61017626678564e-37 NA NA NA hsa-miR-590-5p LRP1 0.746515607868274 8.51300479640125e-09 -1.59623069924697 7.26581692175772e-39 miRanda -0.378699723419783 2.26371149323376e-31 NA NA NA hsa-miR-9-5p LRP1 0.734772328078424 0.00261982843636383 -1.59623069924697 7.26581692175772e-39 miRNAWalker2_validate -0.124757469565155 2.13706736496441e-12 NA NA NA hsa-miR-140-5p LRRC15 -0.755971041589807 9.68060922934542e-14 3.53392343171925 7.8456170163519e-53 miRanda -0.340745929925161 3.40278741694763e-05 NA NA NA hsa-miR-17-3p LRRC15 0.721439431208839 7.95900548819742e-10 3.53392343171925 7.8456170163519e-53 mirMAP -0.353226723476824 7.02867579662182e-07 NA NA NA hsa-miR-224-5p LRRC15 -2.22249420723892 1.07787949391113e-18 3.53392343171925 7.8456170163519e-53 mirMAP -0.169795004694771 2.01025878841557e-07 NA NA NA hsa-miR-30a-5p LRRC15 -0.392489994825279 0.00954894667761676 3.53392343171925 7.8456170163519e-53 mirMAP -0.302304417697272 5.15116287115859e-08 NA NA NA hsa-miR-30b-5p LRRC15 -0.46540603860146 2.4709940429591e-05 3.53392343171925 7.8456170163519e-53 mirMAP -0.658224938569325 1.84545796376392e-18 NA NA NA hsa-miR-30c-5p LRRC15 -0.393222674580066 8.06961465717306e-05 3.53392343171925 7.8456170163519e-53 mirMAP -0.665667958618889 1.63296093066273e-15 NA NA NA hsa-miR-30d-5p LRRC15 -0.247082219011045 0.00406717930063148 3.53392343171925 7.8456170163519e-53 mirMAP -0.834527435851159 8.08431685644038e-18 NA NA NA hsa-miR-30e-5p LRRC15 0.293491764699475 0.000372291967271834 3.53392343171925 7.8456170163519e-53 mirMAP -0.471047451931101 4.55791978866943e-06 NA NA NA hsa-miR-374a-5p LRRC15 -0.239709888246804 0.00309819667153627 3.53392343171925 7.8456170163519e-53 mirMAP -0.55593673133992 1.03629082419154e-07 NA NA NA hsa-miR-374b-5p LRRC15 -0.466781429946153 1.17238311619116e-08 3.53392343171925 7.8456170163519e-53 mirMAP -0.619924104906752 1.45356425657533e-09 NA NA NA hsa-miR-16-2-3p LUM 0.286355254959005 0.0256946046884474 0.297428675203928 0.0702771383772814 mirMAP -0.315006466079763 5.28773564829486e-13 NA NA NA hsa-miR-590-3p LUM 1.27438512890514 1.03164723481469e-23 0.297428675203928 0.0702771383772814 miRanda;mirMAP -0.223271286048763 6.75779337393335e-07 NA NA NA hsa-miR-590-5p LUM 0.746515607868274 8.51300479640125e-09 0.297428675203928 0.0702771383772814 MirTarget;PITA;miRanda -0.266966217117055 4.3064554524157e-10 NA NA NA hsa-miR-7-1-3p LUM 0.686579567507582 1.20731554448806e-07 0.297428675203928 0.0702771383772814 mirMAP -0.206074836115016 1.62727670420061e-06 NA NA NA hsa-miR-146b-5p MAGEE1 0.631041661167954 6.20366593452965e-08 -0.203861589999967 0.0328652866912518 miRanda -0.203151656472214 1.68610093958929e-13 NA NA NA hsa-miR-485-3p MAGEE1 -0.866822427729628 4.5194665263492e-11 -0.203861589999967 0.0328652866912518 MirTarget -0.101576808009675 4.23807805787773e-05 NA NA NA hsa-miR-590-3p MAGEE1 1.27438512890514 1.03164723481469e-23 -0.203861589999967 0.0328652866912518 miRanda -0.124186419458619 2.02069321048242e-06 NA NA NA hsa-miR-671-5p MAGEE1 1.55248047544015 7.7377784125886e-33 -0.203861589999967 0.0328652866912518 MirTarget -0.106354280627715 1.53862496586795e-05 NA NA NA hsa-miR-21-5p MATN2 2.32007501846389 3.08394781855554e-137 -3.29740104225744 3.25541820206151e-67 miRNATAP -0.768197434664512 2.45662210651958e-35 NA NA NA hsa-miR-375 MATN2 2.09893673049766 1.68351780396203e-16 -3.29740104225744 3.25541820206151e-67 miRanda -0.227583597666673 2.21902441570678e-17 NA NA NA hsa-miR-590-3p MATN2 1.27438512890514 1.03164723481469e-23 -3.29740104225744 3.25541820206151e-67 miRanda;mirMAP;miRNATAP -0.467319394997235 6.66736612020705e-17 NA NA NA hsa-miR-590-5p MATN2 0.746515607868274 8.51300479640125e-09 -3.29740104225744 3.25541820206151e-67 PITA;miRanda;miRNATAP -0.373584253002543 3.82565531696959e-12 NA NA NA hsa-miR-125a-3p MATN3 -0.176412960953959 0.10108079286419 2.47660697819003 7.61520279276486e-36 miRanda -0.262445108069216 7.40856951611363e-05 NA NA NA hsa-miR-126-5p MATN3 -1.27745588751177 2.96000918537631e-30 2.47660697819003 7.61520279276486e-36 mirMAP;miRNATAP -0.345283376172068 1.48761939177923e-08 NA NA NA hsa-miR-130a-3p MATN3 -1.15024914519431 6.51290317952496e-19 2.47660697819003 7.61520279276486e-36 MirTarget -0.271852028112413 3.64670016790451e-07 NA NA NA hsa-miR-130b-3p MATN3 1.38122163823846 1.00932179737836e-26 2.47660697819003 7.61520279276486e-36 MirTarget -0.210239567660092 8.6096764103482e-05 NA NA NA hsa-miR-19a-3p MATN3 0.817507952171848 3.76285090469625e-08 2.47660697819003 7.61520279276486e-36 MirTarget -0.367152499431167 3.77994043324715e-15 NA NA NA hsa-miR-19b-3p MATN3 0.139124391010031 0.255658553872934 2.47660697819003 7.61520279276486e-36 MirTarget -0.534276618628321 5.34786560410426e-21 NA NA NA hsa-miR-24-3p MATN3 -0.120123317289941 0.21432376743243 2.47660697819003 7.61520279276486e-36 miRNATAP -0.519771416443144 9.9535706175374e-13 NA NA NA hsa-miR-27a-3p MATN3 0.388496361379095 1.42373532086331e-05 2.47660697819003 7.61520279276486e-36 MirTarget;miRNATAP -0.221973591458689 0.0052166084630059 NA NA NA hsa-miR-584-5p MATN3 -1.75458362433615 2.80754771470968e-33 2.47660697819003 7.61520279276486e-36 MirTarget -0.621815083754273 6.68785494612692e-45 NA NA NA hsa-miR-590-3p MATN3 1.27438512890514 1.03164723481469e-23 2.47660697819003 7.61520279276486e-36 miRanda;mirMAP -0.286347587257234 4.31434001212043e-07 NA NA NA hsa-let-7b-5p MCM7 -0.54215483448257 7.21347617597858e-08 0.68267767406409 5.54088787186384e-14 miRNAWalker2_validate -0.24631747761265 1.17772037587033e-15 NA NA NA hsa-miR-107 MEST 0.678998026350662 2.56224148930538e-16 -1.87820766081128 3.91503997331289e-33 miRanda -0.186104212629461 0.0052816855441434 NA NA NA hsa-miR-155-5p MEST 1.09766314984151 4.55650930885814e-15 -1.87820766081128 3.91503997331289e-33 miRNAWalker2_validate -0.13630668023442 0.00051579188377208 NA NA NA hsa-miR-29b-3p MEST 0.438847962603729 6.46722433236121e-05 -1.87820766081128 3.91503997331289e-33 MirTarget;miRNATAP -0.256825828533309 3.90234132668466e-07 NA NA NA hsa-miR-3065-3p MEST 1.62787885002468 6.81477830005026e-19 -1.87820766081128 3.91503997331289e-33 MirTarget;miRNATAP -0.157347982800913 1.10837382706802e-07 NA NA NA hsa-miR-330-5p MEST 0.626063225953928 3.42215028606779e-09 -1.87820766081128 3.91503997331289e-33 miRanda;miRNATAP -0.162260075189317 0.00198472592530244 NA NA NA hsa-miR-429 MEST 2.84108892259147 3.88520896426515e-64 -1.87820766081128 3.91503997331289e-33 miRanda;miRNATAP -0.269458655818472 5.4521430595406e-19 NA NA NA hsa-miR-455-5p MEST 0.284641224662773 0.0357572339594277 -1.87820766081128 3.91503997331289e-33 miRanda -0.172534728048054 2.82020262909635e-05 NA NA NA hsa-miR-590-3p MEST 1.27438512890514 1.03164723481469e-23 -1.87820766081128 3.91503997331289e-33 PITA;miRanda -0.178969355135805 6.32401777826943e-05 NA NA NA hsa-miR-15a-5p MFAP5 0.812445324157528 4.50263417099822e-20 -1.7372996699481 1.15820603382006e-18 MirTarget -0.553006034014218 2.53128117033741e-13 NA NA NA hsa-miR-15b-5p MFAP5 0.788659356634696 1.13678211092534e-11 -1.7372996699481 1.15820603382006e-18 MirTarget -0.255439067919961 1.31902656032592e-05 NA NA NA hsa-miR-200b-3p MFAP5 2.11744072703209 1.66710572104191e-43 -1.7372996699481 1.15820603382006e-18 TargetScan -0.416640331285456 1.23444205417206e-23 NA NA NA hsa-miR-200c-3p MFAP5 2.07038651806183 6.84613386286599e-51 -1.7372996699481 1.15820603382006e-18 miRNATAP -0.504700300707793 1.08619258765981e-28 NA NA NA hsa-miR-320b MFAP5 0.412787504747938 0.00113457276903985 -1.7372996699481 1.15820603382006e-18 miRanda -0.153737987084261 0.00494116044855495 NA NA NA hsa-miR-361-5p MFAP5 -0.0996867547900457 0.095428250126326 -1.7372996699481 1.15820603382006e-18 miRanda -0.472200194963825 5.5911691834756e-05 NA NA NA hsa-miR-429 MFAP5 2.84108892259147 3.88520896426515e-64 -1.7372996699481 1.15820603382006e-18 miRanda;miRNATAP -0.362088653325579 2.10248513316363e-22 NA NA NA hsa-miR-590-3p MFAP5 1.27438512890514 1.03164723481469e-23 -1.7372996699481 1.15820603382006e-18 miRanda;mirMAP -0.286800933293875 1.8764047768299e-07 NA NA NA hsa-miR-145-5p MMP1 -2.62703571936687 7.64402900188551e-88 6.06794406171332 1.97080965138208e-60 miRNAWalker2_validate -0.776560200165228 1.4991690670364e-17 NA NA NA hsa-miR-361-5p MMP1 -0.0996867547900457 0.095428250126326 6.06794406171332 1.97080965138208e-60 miRanda -0.642409660244435 0.00584964323015371 NA NA NA hsa-miR-125a-5p MMP14 -0.635694700253268 3.6703235721638e-11 1.17709675366481 4.88698053995378e-22 mirMAP -0.228069262745624 2.33168902402985e-07 NA NA NA hsa-miR-145-5p MMP14 -2.62703571936687 7.64402900188551e-88 1.17709675366481 4.88698053995378e-22 miRNAWalker2_validate -0.100472607295886 0.00054272881478419 NA NA NA hsa-miR-26a-5p MMP14 -0.481180084102235 1.82368246174758e-10 1.17709675366481 4.88698053995378e-22 miRNATAP -0.37891915943683 1.49265787066053e-11 NA NA NA hsa-miR-26b-5p MMP14 -0.331527896896866 0.000551258576575092 1.17709675366481 4.88698053995378e-22 miRNATAP -0.325679401433157 1.76103199160772e-13 NA NA NA hsa-miR-29b-2-5p MMP14 -0.263499971180298 0.0400001755611965 1.17709675366481 4.88698053995378e-22 mirMAP -0.335108350461695 7.24529744983042e-25 NA NA NA hsa-miR-335-5p MMP14 -2.61355235628987 2.6462884165886e-51 1.17709675366481 4.88698053995378e-22 miRNAWalker2_validate -0.209036899933566 3.86604363416133e-20 NA NA NA hsa-miR-361-3p MMP14 -0.0370446538644886 0.624902392829872 1.17709675366481 4.88698053995378e-22 mirMAP -0.1791783083358 0.00173381225130026 NA NA NA hsa-miR-625-5p MMP14 0.728939236913178 5.97591217674307e-08 1.17709675366481 4.88698053995378e-22 mirMAP -0.128736781151779 8.0995218297369e-05 NA NA NA hsa-miR-125a-5p MMP2 -0.635694700253268 3.6703235721638e-11 -0.242139147715788 0.0918764978170719 miRanda -0.170087179816706 0.000820316003488761 NA NA NA hsa-miR-17-5p MMP2 0.599531757298529 1.07318660415906e-05 -0.242139147715788 0.0918764978170719 miRNAWalker2_validate;TargetScan -0.350519936812557 1.55537121347669e-23 NA NA NA hsa-miR-29b-3p MMP2 0.438847962603729 6.46722433236121e-05 -0.242139147715788 0.0918764978170719 miRNAWalker2_validate;miRTarBase;miRNATAP -0.457073823772732 7.32941173306703e-26 26155940;20657750;25866219;24130681;24130168;26063204 In this study we found that only miR-29b inhibited tumor cell migration and invasion by reducing MMP-2 activity via phospho-AKT/β-catenin signaling and stimulated a more epithelial-like morphology;Further a novel target with potential implications for invasion and metastasis matrix metallopeptidase-2 MMP-2 was identified and confirmed to be a miR-29b target in prostate cancer cells;miR 29b inhibits the progression of esophageal squamous cell carcinoma by targeting MMP 2; The impact of overexpression of miR-29b on putative target MMP-2 were subsequently confirmed via Western blot; Overexpression of miR-29b significantly decreased p<0.05 the protein level of MMP-2 which has previously been identified as a direct target of miR-29b; Thus our study demonstrated that overexpression of miR-29b inhibits tumor growth in part by targeting MMP-2;Since miR-29b plays a role in regulating the migration of cancer cells we hypothesized that HAG induces miR-29b expression to target matrix metalloproteinase-2 MMP-2 thereby suppressing the migration of colon cancer cells; Our study supports the understanding that targeting MMP-2 by miR-29b is a mechanism by which HAG suppresses the migration of colon cancer cells;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC;Furthermore the dual-luciferase reporter assay demonstrated that miR-29b inhibited the expression of the luciferase gene containing the 3'-UTRs of MMP2 and PTEN mRNA; Western blotting and quantitative RT-PCR indicated that miR-29b down-regulated the expression of MMP2 at the protein and mRNA levels; Taken together our results demonstrate that miR-29b serves as a tumor metastasis suppressor which suppresses NSCLC cell metastasis by directly inhibiting MMP2 expression cell migration;metastasis;progression;;;metastasis glioblastoma;prostate cancer;esophageal cancer;colon cancer;gastric cancer;lung squamous cell cancer hsa-miR-29c-3p MMP2 -0.0652732378039769 0.563774115756922 -0.242139147715788 0.0918764978170719 miRNATAP -0.240334589632784 3.08320771048653e-08 23936390;25863127 Furthermore the dual-luciferase reporter assay demonstrated that miR-29c inhibited the expression of the luciferase gene containing the 3'-UTRs of integrin β1 and MMP2 mRNA; Western blotting indicated that miR-29c downregulated the expression of integrin β1 and MMP2 at the protein level; Gelatin zymography analysis further confirmed that miR-29c decreased MMP2 enzyme activity;miR-29c suppresses cell migration and invasion by targeting the MMP2 3'UTR; miR-29c plays an important role in mediating pancreatic cancer metastasis to the liver by targeting MMP2 ;cell migration;metastasis lung cancer;pancreatic cancer hsa-miR-3065-3p MMP2 1.62787885002468 6.81477830005026e-19 -0.242139147715788 0.0918764978170719 miRNATAP -0.166637463866081 1.45048524162274e-10 NA NA NA hsa-miR-330-3p MMP2 0.432728362037032 0.00041335506960812 -0.242139147715788 0.0918764978170719 miRNATAP -0.186233595999659 4.36346021182179e-06 NA NA NA hsa-miR-338-3p MMP2 0.0799903526884966 0.575137668326679 -0.242139147715788 0.0918764978170719 miRNAWalker2_validate -0.244191536578136 8.22673144530474e-13 NA NA NA hsa-miR-17-5p MMP3 0.599531757298529 1.07318660415906e-05 2.51988325716288 1.51511806597889e-20 MirTarget -0.184697578648555 0.00806978222817155 NA NA NA hsa-miR-20a-5p MMP3 0.44979911120222 0.000602386964327228 2.51988325716288 1.51511806597889e-20 MirTarget -0.194328870244658 0.007437720219106 NA NA NA hsa-miR-21-5p MSX1 2.32007501846389 3.08394781855554e-137 -0.862768844272717 2.12249217087809e-12 miRNATAP -0.103509234308864 0.00763262040296447 NA NA NA hsa-miR-590-3p MSX1 1.27438512890514 1.03164723481469e-23 -0.862768844272717 2.12249217087809e-12 miRanda -0.244222101416861 4.66108038564072e-13 NA NA NA hsa-miR-590-5p MSX1 0.746515607868274 8.51300479640125e-09 -0.862768844272717 2.12249217087809e-12 miRanda;miRNATAP -0.227388835203913 1.87764413279199e-12 NA NA NA hsa-miR-101-3p MXRA5 -0.126035286271986 0.145997832808138 0.858602981221213 1.15597151175191e-09 miRNATAP -0.312476684242103 2.93244890194577e-08 NA NA NA hsa-miR-139-5p MXRA5 -3.25846663863766 2.62018989415003e-112 0.858602981221213 1.15597151175191e-09 miRanda -0.16134676472261 3.0596149295001e-08 NA NA NA hsa-miR-185-5p MXRA5 0.482334746589337 3.68475879959415e-09 0.858602981221213 1.15597151175191e-09 MirTarget -0.271779570704394 4.74032652942802e-06 NA NA NA hsa-miR-30a-5p MXRA5 -0.392489994825279 0.00954894667761676 0.858602981221213 1.15597151175191e-09 miRNATAP -0.202271854370552 2.35901850909144e-10 NA NA NA hsa-miR-30c-2-3p MXRA5 -0.793306601708467 2.88673428932496e-07 0.858602981221213 1.15597151175191e-09 MirTarget -0.198461663136751 1.7047349721383e-10 NA NA NA hsa-miR-30d-5p MXRA5 -0.247082219011045 0.00406717930063148 0.858602981221213 1.15597151175191e-09 miRNATAP -0.412944631042553 2.27125374682456e-13 NA NA NA hsa-miR-335-3p MXRA5 -1.88448538773649 2.09538234398335e-32 0.858602981221213 1.15597151175191e-09 MirTarget -0.116668050009186 7.45196953677672e-05 NA NA NA hsa-miR-590-3p MXRA5 1.27438512890514 1.03164723481469e-23 0.858602981221213 1.15597151175191e-09 MirTarget;PITA;miRanda -0.101490664901601 0.00957023780973862 NA NA NA hsa-miR-330-5p MYL9 0.626063225953928 3.42215028606779e-09 -1.44061917021777 7.12558251178902e-34 MirTarget;miRanda -0.296330916307387 4.38915210939392e-14 NA NA NA hsa-let-7a-3p MYLK 0.466622567891891 3.70886257943079e-07 -2.468210552686 9.30073457733719e-63 mirMAP -0.201102417857029 0.000732841839560927 NA NA NA hsa-miR-107 MYLK 0.678998026350662 2.56224148930538e-16 -2.468210552686 9.30073457733719e-63 miRanda -0.727441031317099 7.55254848021747e-31 NA NA NA hsa-miR-142-3p MYLK 1.53951237846104 2.06769936282034e-17 -2.468210552686 9.30073457733719e-63 PITA;miRanda -0.109303156504941 0.000215677439149484 NA NA NA hsa-miR-142-5p MYLK 1.16509303143593 1.96641162209073e-13 -2.468210552686 9.30073457733719e-63 mirMAP -0.111648331619493 0.00103415496364014 NA NA NA hsa-miR-15a-5p MYLK 0.812445324157528 4.50263417099822e-20 -2.468210552686 9.30073457733719e-63 MirTarget;miRNATAP -0.743003329521289 1.84671570815489e-37 NA NA NA hsa-miR-15b-5p MYLK 0.788659356634696 1.13678211092534e-11 -2.468210552686 9.30073457733719e-63 MirTarget;miRNATAP -0.420267831335879 3.27608321136071e-20 NA NA NA hsa-miR-16-2-3p MYLK 0.286355254959005 0.0256946046884474 -2.468210552686 9.30073457733719e-63 mirMAP -0.267488974977824 3.40977165184367e-10 NA NA NA hsa-miR-16-5p MYLK 0.46835991343556 1.91125356547776e-06 -2.468210552686 9.30073457733719e-63 MirTarget;miRNATAP -0.386648645982304 1.99154564341007e-12 NA NA NA hsa-miR-193a-3p MYLK 0.310617999804917 0.00477640270974957 -2.468210552686 9.30073457733719e-63 miRanda -0.183797302313369 0.000221311854270132 NA NA NA hsa-miR-200b-3p MYLK 2.11744072703209 1.66710572104191e-43 -2.468210552686 9.30073457733719e-63 TargetScan -0.309913441680872 8.09237031263242e-21 NA NA NA hsa-miR-320b MYLK 0.412787504747938 0.00113457276903985 -2.468210552686 9.30073457733719e-63 miRanda -0.146562676450802 0.000723733397528372 NA NA NA hsa-miR-340-5p MYLK 1.0857159627596 4.94471062546756e-24 -2.468210552686 9.30073457733719e-63 MirTarget;mirMAP -0.423652824268149 3.77106743930004e-18 NA NA NA hsa-miR-429 MYLK 2.84108892259147 3.88520896426515e-64 -2.468210552686 9.30073457733719e-63 PITA;miRanda;miRNATAP -0.336023519715106 1.14874203218121e-30 NA NA NA hsa-miR-590-3p MYLK 1.27438512890514 1.03164723481469e-23 -2.468210552686 9.30073457733719e-63 MirTarget;miRanda;mirMAP -0.319629509007646 1.61044526555788e-13 NA NA NA hsa-miR-590-5p MYLK 0.746515607868274 8.51300479640125e-09 -2.468210552686 9.30073457733719e-63 miRanda -0.207142520900471 7.06320969717734e-07 NA NA NA hsa-miR-101-3p NID2 -0.126035286271986 0.145997832808138 0.369657776320535 0.00325891227612303 miRNATAP -0.35738916792756 4.91199615823436e-13 NA NA NA hsa-miR-181d-5p NID2 0.782618466877349 1.2821116358212e-09 0.369657776320535 0.00325891227612303 miRNAWalker2_validate -0.189435395345092 8.734018135097e-09 NA NA NA hsa-miR-30a-5p NID2 -0.392489994825279 0.00954894667761676 0.369657776320535 0.00325891227612303 miRNATAP -0.213022578586841 3.07408747103877e-14 NA NA NA hsa-miR-30c-5p NID2 -0.393222674580066 8.06961465717306e-05 0.369657776320535 0.00325891227612303 miRNATAP -0.383047956901651 1.47236261592227e-19 NA NA NA hsa-miR-30d-5p NID2 -0.247082219011045 0.00406717930063148 0.369657776320535 0.00325891227612303 miRNATAP -0.441633503672466 3.62415437290673e-19 NA NA NA hsa-miR-361-5p NID2 -0.0996867547900457 0.095428250126326 0.369657776320535 0.00325891227612303 miRanda -0.435952491698067 2.1080023359267e-09 NA NA NA hsa-miR-590-3p NID2 1.27438512890514 1.03164723481469e-23 0.369657776320535 0.00325891227612303 miRanda;mirMAP -0.107536048890623 0.00186113064345138 NA NA NA hsa-miR-590-5p NID2 0.746515607868274 8.51300479640125e-09 0.369657776320535 0.00325891227612303 miRanda -0.107182534631482 0.00116985190023622 NA NA NA hsa-miR-98-5p NNMT 0.656336869298973 9.03113188590466e-15 -0.58374331490313 6.16865987304583e-06 miRNAWalker2_validate -0.18723111175966 0.000313285045290708 NA NA NA hsa-miR-103a-3p NOTCH2 0.610673390034345 1.63113920514646e-12 -0.56663957212087 4.13195343694927e-10 MirTarget -0.393489735620895 1.21744228897107e-29 NA NA NA hsa-miR-107 NOTCH2 0.678998026350662 2.56224148930538e-16 -0.56663957212087 4.13195343694927e-10 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.295064220944387 1.12205879906685e-15 NA NA NA hsa-miR-15a-5p NOTCH2 0.812445324157528 4.50263417099822e-20 -0.56663957212087 4.13195343694927e-10 MirTarget -0.336096048813986 3.78944707422762e-23 NA NA NA hsa-miR-16-1-3p NOTCH2 1.30142784811196 2.53343713753744e-29 -0.56663957212087 4.13195343694927e-10 mirMAP -0.117221830255969 2.31872395352777e-05 NA NA NA hsa-miR-181a-5p NOTCH2 0.635863607630183 6.72486918157744e-11 -0.56663957212087 4.13195343694927e-10 miRNAWalker2_validate;MirTarget;mirMAP -0.131467724390005 3.78506969785607e-05 NA NA NA hsa-miR-181b-5p NOTCH2 1.22749257795094 1.21998198830919e-27 -0.56663957212087 4.13195343694927e-10 MirTarget;mirMAP -0.134438102680875 5.65413228477333e-07 NA NA NA hsa-miR-181c-5p NOTCH2 0.574847839298605 4.51287502066478e-07 -0.56663957212087 4.13195343694927e-10 miRNAWalker2_validate;MirTarget -0.144428010158692 1.1989367673789e-07 26983574;25494473 This is supported by the depletion of CTCF in glioblastoma cells affecting the expression levels of NOTCH2 as a target of miR-181c;Finally investigation of the mechanism defined Notch2 a key molecular of Notch signaling as the functional downstream target of miR-181c; An inverse correlation was found between miR-181c and Notch2 in glioma cells and verified in fresh glioma samples; miR-181c acts as a tumor suppressor that attenuates proliferation invasion and self-renewal capacities by downregulation of Notch2 in glioma cells ; glioblastoma;glioblastoma hsa-miR-181d-5p NOTCH2 0.782618466877349 1.2821116358212e-09 -0.56663957212087 4.13195343694927e-10 MirTarget -0.113330370423903 2.42203716084369e-06 NA NA NA hsa-miR-185-5p NOTCH2 0.482334746589337 3.68475879959415e-09 -0.56663957212087 4.13195343694927e-10 MirTarget -0.264656556620792 2.73432150118289e-12 NA NA NA hsa-miR-25-3p NOTCH2 -0.00546790775985073 0.944061771389468 -0.56663957212087 4.13195343694927e-10 miRNAWalker2_validate -0.156141333521494 0.000119795226054369 NA NA NA hsa-miR-29c-3p NOTCH2 -0.0652732378039769 0.563774115756922 -0.56663957212087 4.13195343694927e-10 MirTarget -0.206837949620811 5.00356369591601e-14 NA NA NA hsa-miR-340-5p NOTCH2 1.0857159627596 4.94471062546756e-24 -0.56663957212087 4.13195343694927e-10 mirMAP -0.200925164274976 9.46541690035449e-13 NA NA NA hsa-miR-34a-5p NOTCH2 0.129201805242403 0.133261654068224 -0.56663957212087 4.13195343694927e-10 miRNAWalker2_validate;miRNATAP -0.108914801108399 0.00301789969264899 NA NA NA hsa-miR-423-5p NOTCH2 -0.0644843381453004 0.462275547464843 -0.56663957212087 4.13195343694927e-10 MirTarget -0.125312605385814 0.000498899203823204 NA NA NA hsa-miR-148a-5p NT5E 0.572692271754695 2.14306251522796e-06 -1.39120942119135 6.04701380515517e-27 miRNATAP -0.161853143979952 1.7478233507858e-05 NA NA NA hsa-miR-30a-5p NT5E -0.392489994825279 0.00954894667761676 -1.39120942119135 6.04701380515517e-27 miRNAWalker2_validate;miRNATAP -0.164576604552941 4.35448536782974e-08 NA NA NA hsa-miR-30c-5p NT5E -0.393222674580066 8.06961465717306e-05 -1.39120942119135 6.04701380515517e-27 miRNATAP -0.169570686471524 0.000221417926430919 NA NA NA hsa-miR-30d-5p NT5E -0.247082219011045 0.00406717930063148 -1.39120942119135 6.04701380515517e-27 miRNATAP -0.237814360880141 8.43665394425386e-06 NA NA NA hsa-miR-590-3p NT5E 1.27438512890514 1.03164723481469e-23 -1.39120942119135 6.04701380515517e-27 PITA;miRanda -0.103022642441023 0.00506307187255707 NA NA NA hsa-miR-30a-5p NTM -0.392489994825279 0.00954894667761676 0.221487289190883 0.123560204043128 miRNATAP -0.20183994495154 3.76839127535762e-10 NA NA NA hsa-miR-30b-3p NTM -0.536462824497982 2.41814659272548e-05 0.221487289190883 0.123560204043128 MirTarget -0.102817670323971 0.00826237233021248 NA NA NA hsa-miR-30c-5p NTM -0.393222674580066 8.06961465717306e-05 0.221487289190883 0.123560204043128 miRNATAP -0.383169893903739 3.45592088959484e-15 NA NA NA hsa-miR-30d-5p NTM -0.247082219011045 0.00406717930063148 0.221487289190883 0.123560204043128 miRNATAP -0.368958188169536 9.88507357650264e-11 NA NA NA hsa-miR-361-5p NTM -0.0996867547900457 0.095428250126326 0.221487289190883 0.123560204043128 MirTarget;miRanda;miRNATAP -0.400722946124754 1.5925257419292e-06 NA NA NA hsa-miR-374b-5p NTM -0.466781429946153 1.17238311619116e-08 0.221487289190883 0.123560204043128 miRNATAP -0.186908545541069 0.00188272194787225 NA NA NA hsa-miR-429 NTM 2.84108892259147 3.88520896426515e-64 0.221487289190883 0.123560204043128 miRanda;miRNATAP -0.116202019495312 1.87021588467903e-05 NA NA NA hsa-miR-942-5p NTM 0.0274758353801279 0.842368857038259 0.221487289190883 0.123560204043128 MirTarget -0.182675436251697 2.97158819428497e-07 NA NA NA hsa-miR-29b-3p OXTR 0.438847962603729 6.46722433236121e-05 -4.04712904491628 1.48672631195987e-66 miRNATAP -0.435399946655863 3.8045498783701e-08 NA NA NA hsa-miR-590-3p OXTR 1.27438512890514 1.03164723481469e-23 -4.04712904491628 1.48672631195987e-66 mirMAP -0.588866126780031 1.26607175649504e-17 NA NA NA hsa-miR-590-5p OXTR 0.746515607868274 8.51300479640125e-09 -4.04712904491628 1.48672631195987e-66 miRanda -0.399071341493331 2.02844254873861e-09 NA NA NA hsa-miR-130b-5p PCOLCE2 1.0573161199584 2.55177349228739e-12 -5.34447065684793 3.25334281900878e-61 MirTarget -0.23578238083524 0.00262301911153533 NA NA NA hsa-miR-182-5p PCOLCE2 2.36408084103818 2.60011457600281e-72 -5.34447065684793 3.25334281900878e-61 miRNAWalker2_validate -1.11108386331257 4.95592616347093e-45 NA NA NA hsa-miR-192-5p PCOLCE2 1.33366224451777 9.5116159697107e-29 -5.34447065684793 3.25334281900878e-61 miRNAWalker2_validate -0.667189201290073 3.05707018161735e-12 NA NA NA hsa-miR-32-5p PCOLCE2 1.38676603945192 2.29428299685976e-34 -5.34447065684793 3.25334281900878e-61 MirTarget -0.57459700604009 1.22481328284014e-08 NA NA NA hsa-miR-342-3p PCOLCE2 1.21944481975657 6.81914373001202e-19 -5.34447065684793 3.25334281900878e-61 miRanda -0.799629325489688 9.25043003060431e-22 NA NA NA hsa-miR-508-3p PCOLCE2 0.260698649973977 0.189926238144551 -5.34447065684793 3.25334281900878e-61 PITA -0.205809678615259 0.000697442372783433 NA NA NA hsa-miR-590-3p PCOLCE2 1.27438512890514 1.03164723481469e-23 -5.34447065684793 3.25334281900878e-61 MirTarget;miRanda -0.379554325879054 7.63269367268395e-05 NA NA NA hsa-miR-92b-3p PCOLCE2 1.30248132773644 9.42428674470985e-25 -5.34447065684793 3.25334281900878e-61 MirTarget -0.460196195635653 4.91257183628433e-07 NA NA NA hsa-miR-29a-3p PDGFRB -0.699539666833076 1.13935003139957e-13 -0.363053423609744 0.000930448280520273 miRNATAP -0.173489965488495 1.08203138499797e-05 NA NA NA hsa-miR-29b-3p PDGFRB 0.438847962603729 6.46722433236121e-05 -0.363053423609744 0.000930448280520273 miRNATAP -0.37404884670886 1.21864334087282e-29 NA NA NA hsa-miR-29c-3p PDGFRB -0.0652732378039769 0.563774115756922 -0.363053423609744 0.000930448280520273 miRNATAP -0.131693600188518 7.8570505856864e-05 NA NA NA hsa-miR-3127-5p PDGFRB 0.903405128081314 1.1325923598273e-12 -0.363053423609744 0.000930448280520273 mirMAP -0.190856341471899 4.71469241759899e-11 NA NA NA hsa-miR-338-3p PDGFRB 0.0799903526884966 0.575137668326679 -0.363053423609744 0.000930448280520273 miRanda -0.135507787608143 2.53645768220537e-07 NA NA NA hsa-miR-342-3p PDGFRB 1.21944481975657 6.81914373001202e-19 -0.363053423609744 0.000930448280520273 miRanda -0.120554527834238 6.56852598546147e-06 NA NA NA hsa-miR-361-3p PDGFRB -0.0370446538644886 0.624902392829872 -0.363053423609744 0.000930448280520273 MirTarget -0.332024100699143 2.34711270011442e-11 NA NA NA hsa-miR-484 PDGFRB 0.349444060004737 0.00154491249625173 -0.363053423609744 0.000930448280520273 mirMAP -0.17421282482312 2.9286066688125e-07 NA NA NA hsa-miR-664a-3p PDGFRB -0.237699857923843 0.0197071390183375 -0.363053423609744 0.000930448280520273 MirTarget -0.173222382702463 2.70287047774181e-06 NA NA NA hsa-miR-193a-3p PDLIM4 0.310617999804917 0.00477640270974957 -0.992486129913858 3.30458803152663e-10 miRanda -0.276427224585698 2.27918921280265e-08 NA NA NA hsa-miR-320b PDLIM4 0.412787504747938 0.00113457276903985 -0.992486129913858 3.30458803152663e-10 mirMAP -0.12773209641215 0.00321145736298762 NA NA NA hsa-miR-324-5p PDLIM4 0.211552647440779 0.139408130311654 -0.992486129913858 3.30458803152663e-10 miRanda -0.276613543018339 2.38371503379475e-13 NA NA NA hsa-miR-326 PDLIM4 -1.54449030848141 1.04703417845594e-17 -0.992486129913858 3.30458803152663e-10 miRanda -0.1630863673959 3.4827124107787e-08 NA NA NA hsa-miR-330-5p PDLIM4 0.626063225953928 3.42215028606779e-09 -0.992486129913858 3.30458803152663e-10 miRanda -0.373778466548125 1.60725740890947e-13 NA NA NA hsa-miR-100-5p PFN2 -1.89453309391092 5.00588682382388e-51 0.388809973780238 0.00142879654721462 miRNAWalker2_validate -0.105459057354451 0.000713881050397803 NA NA NA hsa-miR-139-5p PFN2 -3.25846663863766 2.62018989415003e-112 0.388809973780238 0.00142879654721462 MirTarget;PITA;miRanda -0.172948171730637 3.40038209204324e-12 NA NA NA hsa-miR-218-5p PFN2 -1.02621788318234 2.9221925445771e-23 0.388809973780238 0.00142879654721462 miRNATAP -0.180847970902793 4.47357144366746e-06 NA NA NA hsa-miR-30a-5p PFN2 -0.392489994825279 0.00954894667761676 0.388809973780238 0.00142879654721462 MirTarget;miRNATAP -0.114887256448409 3.05352990462793e-05 NA NA NA hsa-miR-139-5p PLAUR -3.25846663863766 2.62018989415003e-112 1.72201143929991 8.4340887072744e-43 miRanda -0.35194053096789 4.85749810589543e-42 NA NA NA hsa-miR-143-3p PLAUR -1.23248181631499 4.74160976678504e-28 1.72201143929991 8.4340887072744e-43 miRNATAP -0.101588354654431 0.00958055588827153 NA NA NA hsa-miR-195-3p PLAUR -1.49582726452416 6.53261924105147e-40 1.72201143929991 8.4340887072744e-43 MirTarget -0.349871631355842 8.94796848892484e-21 NA NA NA hsa-let-7a-5p PLOD1 -0.210286642041636 0.0072546234707717 0.521002840675697 3.31989407116238e-09 miRNAWalker2_validate -0.228569663407947 4.08323462876395e-09 NA NA NA hsa-miR-149-5p PLOD1 0.218233101703391 0.261629158371175 0.521002840675697 3.31989407116238e-09 miRNAWalker2_validate -0.100498304293261 9.0221384811447e-11 NA NA NA hsa-miR-335-5p PLOD1 -2.61355235628987 2.6462884165886e-51 0.521002840675697 3.31989407116238e-09 MirTarget -0.125991145228986 9.01329780519339e-15 NA NA NA hsa-miR-34c-5p PLOD1 -0.0896438810345765 0.557016551646841 0.521002840675697 3.31989407116238e-09 MirTarget;miRanda;miRNATAP -0.102555885316783 2.70976570274218e-07 NA NA NA hsa-miR-182-5p PLOD2 2.36408084103818 2.60011457600281e-72 -0.195188455576747 0.156394291495433 miRNATAP -0.262093222925603 4.37016004664184e-16 NA NA NA hsa-miR-183-5p PLOD2 2.95681814393872 1.09965777344285e-92 -0.195188455576747 0.156394291495433 miRNAWalker2_validate -0.118606450069159 4.14678296067971e-05 NA NA NA hsa-miR-26a-5p PLOD2 -0.481180084102235 1.82368246174758e-10 -0.195188455576747 0.156394291495433 MirTarget;miRNATAP -0.290056334802037 3.07787236962718e-06 26983694;27310702 Thus our data showed that two genes promoting metastasis LOXL2 and PLOD2 were epigenetically regulated by tumor-suppressive microRNAs miR-26a and miR-26b providing important insights into the molecular mechanisms of RCC metastasis;The gene encoding procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 PLOD2 a collagen crosslinking enzyme was directly regulated by miR-26a-5p and miR-26b-5p; PLOD2 which is associated with the stiffness of the extracellular matrix was directly regulated by miR-26a-5p and miR-26b-5p and may be a good prognostic marker in patients with BC metastasis; kidney renal cell cancer;bladder cancer hsa-miR-429 PLOD2 2.84108892259147 3.88520896426515e-64 -0.195188455576747 0.156394291495433 miRanda -0.108354265284 3.08396822995437e-05 NA NA NA hsa-miR-96-5p PLOD2 3.24596558166606 1.92296159041707e-98 -0.195188455576747 0.156394291495433 MirTarget;TargetScan;miRNATAP -0.15706241240377 6.06497617923989e-09 NA NA NA hsa-miR-491-5p PLOD3 -1.04307210952796 1.14586501470398e-15 0.712781019678456 9.77344493742769e-17 miRanda -0.14208193931182 3.11623031628221e-10 NA NA NA hsa-miR-103a-3p PMEPA1 0.610673390034345 1.63113920514646e-12 0.240695099994048 0.0254456342142221 mirMAP -0.181795144347679 1.70204727566039e-05 NA NA NA hsa-miR-107 PMEPA1 0.678998026350662 2.56224148930538e-16 0.240695099994048 0.0254456342142221 mirMAP -0.17672849449829 5.76523124155326e-05 NA NA NA hsa-miR-16-5p PMEPA1 0.46835991343556 1.91125356547776e-06 0.240695099994048 0.0254456342142221 mirMAP -0.125037240229957 0.000846263730904869 NA NA NA hsa-miR-19a-3p PMEPA1 0.817507952171848 3.76285090469625e-08 0.240695099994048 0.0254456342142221 MirTarget;miRNATAP -0.108455051465864 1.02440074829635e-05 NA NA NA hsa-miR-19b-3p PMEPA1 0.139124391010031 0.255658553872934 0.240695099994048 0.0254456342142221 MirTarget;miRNATAP -0.179588178165817 2.14706582868765e-09 NA NA NA hsa-miR-338-3p PMEPA1 0.0799903526884966 0.575137668326679 0.240695099994048 0.0254456342142221 miRanda -0.147972826151141 8.81364276439147e-09 NA NA NA hsa-miR-625-5p PMEPA1 0.728939236913178 5.97591217674307e-08 0.240695099994048 0.0254456342142221 MirTarget -0.120297401658117 1.83584455628996e-05 NA NA NA hsa-miR-7-1-3p PMEPA1 0.686579567507582 1.20731554448806e-07 0.240695099994048 0.0254456342142221 mirMAP -0.149925083573625 9.81845416606314e-08 NA NA NA hsa-miR-92a-3p PMEPA1 -0.342420481092807 0.000732275969501111 0.240695099994048 0.0254456342142221 miRNATAP -0.223789790166875 6.03250777324371e-10 NA NA NA hsa-miR-29b-3p PMP22 0.438847962603729 6.46722433236121e-05 -0.846523884939232 4.48556003485439e-15 MirTarget;miRNATAP -0.192914472540884 1.38489245510422e-08 NA NA NA hsa-miR-429 PMP22 2.84108892259147 3.88520896426515e-64 -0.846523884939232 4.48556003485439e-15 PITA;miRanda;miRNATAP -0.172480701659585 2.89926476849474e-17 NA NA NA hsa-miR-505-3p PMP22 -0.530462599544864 7.71645736541597e-05 -0.846523884939232 4.48556003485439e-15 MirTarget;miRNATAP -0.10022890314187 0.000333228769228489 NA NA NA hsa-miR-590-3p PMP22 1.27438512890514 1.03164723481469e-23 -0.846523884939232 4.48556003485439e-15 miRanda -0.251925998668243 1.74935449497755e-17 NA NA NA hsa-miR-9-5p PMP22 0.734772328078424 0.00261982843636383 -0.846523884939232 4.48556003485439e-15 MirTarget;miRNATAP -0.111718459141346 1.67969254692813e-13 NA NA NA hsa-miR-139-5p POSTN -3.25846663863766 2.62018989415003e-112 1.95056974229455 5.25551662563458e-27 miRanda -0.292091721092793 1.49042827053157e-14 NA NA NA hsa-miR-140-5p POSTN -0.755971041589807 9.68060922934542e-14 1.95056974229455 5.25551662563458e-27 miRanda -0.211802642642831 0.000697652787214553 NA NA NA hsa-miR-185-5p POSTN 0.482334746589337 3.68475879959415e-09 1.95056974229455 5.25551662563458e-27 MirTarget -0.364976168545916 2.94525010788348e-06 NA NA NA hsa-miR-335-3p POSTN -1.88448538773649 2.09538234398335e-32 1.95056974229455 5.25551662563458e-27 mirMAP -0.187048115524178 1.29177348001135e-06 NA NA NA hsa-miR-590-3p POSTN 1.27438512890514 1.03164723481469e-23 1.95056974229455 5.25551662563458e-27 mirMAP -0.166265774002467 0.00123099534610339 NA NA NA hsa-miR-106b-5p PRRX1 1.22477789913175 2.31787213143326e-32 -0.415469707652431 0.00171921310151227 MirTarget;miRNATAP -0.316342908289087 3.97649267959954e-14 26617763 Down regualtion of miR 106b induces epithelial mesenchymal transition but suppresses metastatic colonization by targeting Prrx1 in colorectal cancer; We identified Prrx1 was a direct target of miR-106b through using target prediction algorithms and dual-Luciferase reporter assay; Moreover Moreover we also found TGF-β1 could down-regulate miR-106b and simultaneously miR-106b also influences the expression of TGF-β1 establishing a negative feedback loop to regulate the expression of Prrx1 together colorectal cancer hsa-miR-16-2-3p PRRX1 0.286355254959005 0.0256946046884474 -0.415469707652431 0.00171921310151227 MirTarget -0.154118445061967 1.50502463168221e-05 NA NA NA hsa-miR-17-5p PRRX1 0.599531757298529 1.07318660415906e-05 -0.415469707652431 0.00171921310151227 MirTarget;TargetScan;miRNATAP -0.222972732214737 1.26744826198333e-11 NA NA NA hsa-miR-200b-5p PRRX1 1.43091697052145 2.07975242866479e-22 -0.415469707652431 0.00171921310151227 mirMAP -0.244393361814474 1.02536306767999e-15 NA NA NA hsa-miR-20a-5p PRRX1 0.44979911120222 0.000602386964327228 -0.415469707652431 0.00171921310151227 MirTarget;miRNATAP -0.296274857215432 2.84582161229866e-18 NA NA NA hsa-miR-330-3p PRRX1 0.432728362037032 0.00041335506960812 -0.415469707652431 0.00171921310151227 PITA;miRNATAP -0.127636867051166 0.000684028724737224 NA NA NA hsa-miR-338-3p PRRX1 0.0799903526884966 0.575137668326679 -0.415469707652431 0.00171921310151227 miRanda -0.229480754346934 3.33775705633109e-13 NA NA NA hsa-miR-340-5p PRRX1 1.0857159627596 4.94471062546756e-24 -0.415469707652431 0.00171921310151227 mirMAP -0.145275577191413 0.000432962342555427 NA NA NA hsa-miR-361-3p PRRX1 -0.0370446538644886 0.624902392829872 -0.415469707652431 0.00171921310151227 PITA -0.292047436811502 1.34147372279503e-06 NA NA NA hsa-miR-590-3p PRRX1 1.27438512890514 1.03164723481469e-23 -0.415469707652431 0.00171921310151227 miRanda;mirMAP;miRNATAP -0.188200713313823 2.14209341815917e-07 NA NA NA hsa-miR-664a-3p PRRX1 -0.237699857923843 0.0197071390183375 -0.415469707652431 0.00171921310151227 mirMAP -0.196407891351673 1.08814597189777e-05 NA NA NA hsa-miR-7-1-3p PRRX1 0.686579567507582 1.20731554448806e-07 -0.415469707652431 0.00171921310151227 mirMAP -0.186728386067344 7.16381508502727e-08 NA NA NA hsa-miR-93-5p PRRX1 1.01788600209314 1.24312921618126e-21 -0.415469707652431 0.00171921310151227 MirTarget;miRNATAP -0.321539979307038 5.34973959823624e-15 NA NA NA hsa-miR-96-5p PRRX1 3.24596558166606 1.92296159041707e-98 -0.415469707652431 0.00171921310151227 MirTarget;TargetScan -0.220128703693586 1.25892229082806e-17 NA NA NA hsa-miR-98-5p PRRX1 0.656336869298973 9.03113188590466e-15 -0.415469707652431 0.00171921310151227 MirTarget -0.198508611346513 0.000187165346283254 NA NA NA hsa-miR-106a-5p PTHLH 0.574594373206545 0.000145868284001732 -1.44742776852114 2.01207752809059e-10 MirTarget;miRNATAP -0.158399320061103 0.00232025774239299 NA NA NA hsa-miR-106b-5p PTHLH 1.22477789913175 2.31787213143326e-32 -1.44742776852114 2.01207752809059e-10 MirTarget -0.531247883774562 2.50562748706036e-13 NA NA NA hsa-miR-107 PTHLH 0.678998026350662 2.56224148930538e-16 -1.44742776852114 2.01207752809059e-10 miRanda -0.645230964737793 3.95294485472285e-12 NA NA NA hsa-miR-15a-5p PTHLH 0.812445324157528 4.50263417099822e-20 -1.44742776852114 2.01207752809059e-10 MirTarget -0.412431133648548 2.22189941123445e-06 NA NA NA hsa-miR-15b-5p PTHLH 0.788659356634696 1.13678211092534e-11 -1.44742776852114 2.01207752809059e-10 MirTarget -0.382395880978935 9.97566678219408e-09 NA NA NA hsa-miR-16-2-3p PTHLH 0.286355254959005 0.0256946046884474 -1.44742776852114 2.01207752809059e-10 mirMAP -0.31316079186682 3.68945185362324e-07 NA NA NA hsa-miR-16-5p PTHLH 0.46835991343556 1.91125356547776e-06 -1.44742776852114 2.01207752809059e-10 MirTarget -0.464500897577237 5.14076887902518e-09 NA NA NA hsa-miR-17-5p PTHLH 0.599531757298529 1.07318660415906e-05 -1.44742776852114 2.01207752809059e-10 MirTarget;TargetScan -0.282741957563029 8.5177284330751e-07 NA NA NA hsa-miR-182-5p PTHLH 2.36408084103818 2.60011457600281e-72 -1.44742776852114 2.01207752809059e-10 MirTarget -0.151853692872458 0.00562453787143307 NA NA NA hsa-miR-200b-3p PTHLH 2.11744072703209 1.66710572104191e-43 -1.44742776852114 2.01207752809059e-10 MirTarget;TargetScan -0.160626397844438 0.000990186901529906 NA NA NA hsa-miR-200c-3p PTHLH 2.07038651806183 6.84613386286599e-51 -1.44742776852114 2.01207752809059e-10 MirTarget -0.21000719036726 8.82486626068071e-05 NA NA NA hsa-miR-20a-5p PTHLH 0.44979911120222 0.000602386964327228 -1.44742776852114 2.01207752809059e-10 MirTarget -0.212466024924017 0.000399904634188589 NA NA NA hsa-miR-20b-5p PTHLH 0.78236583455125 8.7938334801223e-05 -1.44742776852114 2.01207752809059e-10 MirTarget -0.110828395041034 0.0049010239123901 NA NA NA hsa-miR-29b-3p PTHLH 0.438847962603729 6.46722433236121e-05 -1.44742776852114 2.01207752809059e-10 MirTarget -0.309281346135463 1.53816080133893e-05 NA NA NA hsa-miR-3065-3p PTHLH 1.62787885002468 6.81477830005026e-19 -1.44742776852114 2.01207752809059e-10 MirTarget;miRNATAP -0.18532609559024 9.8021261924121e-06 NA NA NA hsa-miR-33a-5p PTHLH 1.35185127289399 9.80509199125785e-12 -1.44742776852114 2.01207752809059e-10 miRNAWalker2_validate -0.212310888125595 9.2817139243987e-08 23458685 We have found that miR-33a which is downregulated in lung cancer cells directly targets PTHrP parathyroid hormone-related protein a potent stimulator of osteoclastic bone resorption leading to decreased osteolytic bone metastasis; We also found that miR-33a levels are inversely correlated with PTHrP expression between human normal bronchial cell line and lung cancer cell lines; These findings have led us to conclude that miR-33a may be a potent tumor suppressor which inhibits direct and indirect osteoclastogenesis through repression of PTHrP miR-33a may even predict a poor prognosis for lung cancer patients metastasis;worse prognosis lung cancer hsa-miR-429 PTHLH 2.84108892259147 3.88520896426515e-64 -1.44742776852114 2.01207752809059e-10 MirTarget;PITA;miRanda -0.192550728734971 9.31406934091461e-06 NA NA NA hsa-miR-576-5p PTHLH 0.0649387707567879 0.588791966096287 -1.44742776852114 2.01207752809059e-10 MirTarget;PITA -0.220133050465357 0.000822314197465255 NA NA NA hsa-miR-590-3p PTHLH 1.27438512890514 1.03164723481469e-23 -1.44742776852114 2.01207752809059e-10 miRanda -0.363319074599778 7.12976802384573e-09 NA NA NA hsa-miR-93-5p PTHLH 1.01788600209314 1.24312921618126e-21 -1.44742776852114 2.01207752809059e-10 MirTarget -0.434301704102916 1.45838498159837e-09 NA NA NA hsa-miR-193a-3p PTX3 0.310617999804917 0.00477640270974957 -2.78450381423429 2.94811759736246e-26 miRanda -0.341733878479359 5.14349021307217e-05 NA NA NA hsa-miR-21-5p PTX3 2.32007501846389 3.08394781855554e-137 -2.78450381423429 2.94811759736246e-26 miRNAWalker2_validate -0.495263579161642 3.54088043602359e-09 NA NA NA hsa-miR-29b-3p PTX3 0.438847962603729 6.46722433236121e-05 -2.78450381423429 2.94811759736246e-26 MirTarget -0.372189737135672 1.01073897656363e-05 NA NA NA hsa-miR-29c-3p PTX3 -0.0652732378039769 0.563774115756922 -2.78450381423429 2.94811759736246e-26 MirTarget -0.433009159776025 1.30856192080426e-07 NA NA NA hsa-miR-330-5p PTX3 0.626063225953928 3.42215028606779e-09 -2.78450381423429 2.94811759736246e-26 miRanda -0.316131628982214 0.000285328861761222 NA NA NA hsa-miR-7-1-3p PTX3 0.686579567507582 1.20731554448806e-07 -2.78450381423429 2.94811759736246e-26 mirMAP -0.463623114019574 4.89024436882388e-11 NA NA NA hsa-let-7b-5p PVR -0.54215483448257 7.21347617597858e-08 0.0787930755688979 0.427345838606977 miRNAWalker2_validate -0.187763035570869 1.90638035016353e-08 NA NA NA hsa-miR-218-5p PVR -1.02621788318234 2.9221925445771e-23 0.0787930755688979 0.427345838606977 mirMAP -0.104772634614801 0.00109362051464013 NA NA NA hsa-miR-34c-5p PVR -0.0896438810345765 0.557016551646841 0.0787930755688979 0.427345838606977 miRanda -0.178165843964702 5.57824709054958e-16 NA NA NA hsa-miR-126-5p QSOX1 -1.27745588751177 2.96000918537631e-30 0.60255748274154 3.62670004110163e-08 mirMAP -0.128854962807061 7.70057796420114e-05 NA NA NA hsa-miR-1271-5p QSOX1 -1.08290983583835 3.85149976357318e-12 0.60255748274154 3.62670004110163e-08 mirMAP -0.117988947749921 9.09699767876162e-07 NA NA NA hsa-miR-142-5p QSOX1 1.16509303143593 1.96641162209073e-13 0.60255748274154 3.62670004110163e-08 mirMAP -0.13539415544689 6.32631291315318e-09 NA NA NA hsa-miR-145-3p QSOX1 -1.74929358701764 6.43728092481753e-62 0.60255748274154 3.62670004110163e-08 mirMAP -0.117952603683783 0.000385800651372884 NA NA NA hsa-miR-150-5p QSOX1 -0.832049526091211 3.45299201139224e-05 0.60255748274154 3.62670004110163e-08 MirTarget -0.130248783205533 1.83244847850503e-12 NA NA NA hsa-miR-193a-5p QSOX1 -1.1508321886378 7.11949564429669e-37 0.60255748274154 3.62670004110163e-08 mirMAP -0.152825748411482 0.000129081741521399 NA NA NA hsa-miR-193b-3p QSOX1 -0.0550374855074773 0.65382485898551 0.60255748274154 3.62670004110163e-08 mirMAP -0.176427216137015 8.57238839574206e-09 NA NA NA hsa-miR-196b-5p QSOX1 -0.302231359742807 0.0833893928085868 0.60255748274154 3.62670004110163e-08 mirMAP -0.116532231984905 5.97285849741674e-08 NA NA NA hsa-miR-20a-3p QSOX1 -0.218902047543766 0.179868363625547 0.60255748274154 3.62670004110163e-08 mirMAP -0.118935735237668 2.64672544172535e-07 NA NA NA hsa-miR-23a-3p QSOX1 -0.217176729033818 0.00962615056202409 0.60255748274154 3.62670004110163e-08 mirMAP -0.217050861847041 1.50649917922337e-06 NA NA NA hsa-miR-23b-3p QSOX1 -0.363202401123049 0.000265305319764878 0.60255748274154 3.62670004110163e-08 mirMAP -0.190348402821462 4.75428222988694e-07 NA NA NA hsa-miR-24-3p QSOX1 -0.120123317289941 0.21432376743243 0.60255748274154 3.62670004110163e-08 MirTarget;mirMAP -0.285992393883525 1.53705687117329e-13 NA NA NA hsa-miR-26a-2-3p QSOX1 -0.142260029503591 0.178539001804738 0.60255748274154 3.62670004110163e-08 mirMAP -0.119267289954462 0.000968820707322421 NA NA NA hsa-miR-28-5p QSOX1 -0.14267073663385 0.0497619246260571 0.60255748274154 3.62670004110163e-08 miRanda -0.152628390389117 0.00364426402193613 NA NA NA hsa-miR-29a-3p QSOX1 -0.699539666833076 1.13935003139957e-13 0.60255748274154 3.62670004110163e-08 mirMAP -0.158341291356019 6.36827186753577e-05 NA NA NA hsa-miR-335-3p QSOX1 -1.88448538773649 2.09538234398335e-32 0.60255748274154 3.62670004110163e-08 mirMAP -0.121239128678486 9.23669302212538e-08 NA NA NA hsa-miR-365a-3p QSOX1 -1.45032725192851 2.37888098061118e-37 0.60255748274154 3.62670004110163e-08 mirMAP -0.163691715855161 2.3554511440414e-07 NA NA NA hsa-miR-378a-3p QSOX1 -1.79882978380301 1.05005373951733e-38 0.60255748274154 3.62670004110163e-08 mirMAP -0.176669397176539 7.13893979595842e-12 NA NA NA hsa-miR-378a-5p QSOX1 -2.43173551693523 1.44932837789175e-68 0.60255748274154 3.62670004110163e-08 mirMAP -0.214841922746055 1.55730998754006e-18 NA NA NA hsa-miR-378c QSOX1 -1.79697571999492 1.07363220292403e-41 0.60255748274154 3.62670004110163e-08 mirMAP -0.215372989540612 6.33369151166999e-16 NA NA NA hsa-miR-423-5p QSOX1 -0.0644843381453004 0.462275547464843 0.60255748274154 3.62670004110163e-08 mirMAP -0.165158957074247 0.000136586425790955 NA NA NA hsa-miR-452-5p QSOX1 -2.48486455572568 1.24430987974325e-33 0.60255748274154 3.62670004110163e-08 mirMAP -0.118738757983793 9.2685056037116e-12 NA NA NA hsa-miR-92a-3p QSOX1 -0.342420481092807 0.000732275969501111 0.60255748274154 3.62670004110163e-08 mirMAP -0.176913050822556 1.93632922632886e-06 NA NA NA hsa-miR-16-2-3p RGS4 0.286355254959005 0.0256946046884474 1.5186584496616 1.05908506042622e-18 MirTarget;mirMAP -0.199924080738451 2.2534117558526e-05 NA NA NA hsa-miR-17-5p RGS4 0.599531757298529 1.07318660415906e-05 1.5186584496616 1.05908506042622e-18 TargetScan -0.189894834864198 1.55859856692056e-05 NA NA NA hsa-miR-193a-5p RGS4 -1.1508321886378 7.11949564429669e-37 1.5186584496616 1.05908506042622e-18 PITA -0.18331632061893 0.00406533037183788 NA NA NA hsa-miR-195-3p RGS4 -1.49582726452416 6.53261924105147e-40 1.5186584496616 1.05908506042622e-18 MirTarget;miRNATAP -0.167523550683284 0.000977864030581061 NA NA NA hsa-miR-26a-5p RGS4 -0.481180084102235 1.82368246174758e-10 1.5186584496616 1.05908506042622e-18 MirTarget;miRNATAP -0.315980371589533 7.13282750132729e-05 NA NA NA hsa-miR-26b-5p RGS4 -0.331527896896866 0.000551258576575092 1.5186584496616 1.05908506042622e-18 MirTarget;miRNATAP -0.233731885001425 0.000199855912764281 NA NA NA hsa-miR-30b-3p RGS4 -0.536462824497982 2.41814659272548e-05 1.5186584496616 1.05908506042622e-18 MirTarget -0.13388603475201 0.00490910603880683 NA NA NA hsa-miR-374b-5p RGS4 -0.466781429946153 1.17238311619116e-08 1.5186584496616 1.05908506042622e-18 MirTarget -0.214965295847644 0.00347843225163845 NA NA NA hsa-miR-455-5p RGS4 0.284641224662773 0.0357572339594277 1.5186584496616 1.05908506042622e-18 PITA;miRanda -0.158895643972944 0.000352098418724479 NA NA NA hsa-miR-486-5p RGS4 -3.87258704301474 1.22658629378451e-80 1.5186584496616 1.05908506042622e-18 PITA;miRanda -0.169974898920676 1.31452936466623e-10 NA NA NA hsa-miR-664a-3p RGS4 -0.237699857923843 0.0197071390183375 1.5186584496616 1.05908506042622e-18 mirMAP -0.195410493845631 0.000979653108329263 NA NA NA hsa-miR-146b-5p RHOB 0.631041661167954 6.20366593452965e-08 -0.173913833425914 0.148250631072104 miRanda -0.275810618183473 1.5519836587237e-15 NA NA NA hsa-miR-19a-3p RHOB 0.817507952171848 3.76285090469625e-08 -0.173913833425914 0.148250631072104 MirTarget;miRNATAP -0.303149520102348 3.60461141738588e-30 26041879 Ras homolog family member B RHOB was identified as a direct target of miR-19a pancreatic cancer hsa-miR-19b-3p RHOB 0.139124391010031 0.255658553872934 -0.173913833425914 0.148250631072104 MirTarget;miRNATAP -0.344690705991017 6.80009411073262e-26 NA NA NA hsa-miR-223-3p RHOB -0.966406159689943 7.90612601654887e-12 -0.173913833425914 0.148250631072104 miRNAWalker2_validate;miRTarBase;MirTarget -0.119176738495152 3.38023083702322e-05 NA NA NA hsa-miR-2355-5p RHOB -0.221733044425126 0.0231054202524677 -0.173913833425914 0.148250631072104 MirTarget -0.262530135773787 4.11207971101164e-10 NA NA NA hsa-miR-330-3p RHOB 0.432728362037032 0.00041335506960812 -0.173913833425914 0.148250631072104 MirTarget;miRNATAP -0.140724022209186 3.44592178174672e-05 NA NA NA hsa-miR-590-3p RHOB 1.27438512890514 1.03164723481469e-23 -0.173913833425914 0.148250631072104 PITA;miRanda -0.349206469459444 9.41202707453476e-28 NA NA NA hsa-miR-590-5p RHOB 0.746515607868274 8.51300479640125e-09 -0.173913833425914 0.148250631072104 PITA;miRanda;miRNATAP -0.374324694692422 3.95389743882122e-35 NA NA NA hsa-miR-629-3p RHOB 1.25035919247365 3.91361135469024e-14 -0.173913833425914 0.148250631072104 mirMAP -0.205754919556506 1.52460633161263e-16 NA NA NA hsa-miR-744-3p RHOB -0.00965764791535539 0.955204760097016 -0.173913833425914 0.148250631072104 MirTarget -0.237632931848451 2.20516093695793e-24 NA NA NA hsa-miR-139-5p SCG2 -3.25846663863766 2.62018989415003e-112 1.91907745779374 2.47137768211596e-21 miRanda -0.134674702058716 0.00161679062975327 NA NA NA hsa-miR-30b-3p SCG2 -0.536462824497982 2.41814659272548e-05 1.91907745779374 2.47137768211596e-21 MirTarget -0.214091217400446 0.000134991437196548 NA NA NA hsa-miR-486-5p SCG2 -3.87258704301474 1.22658629378451e-80 1.91907745779374 2.47137768211596e-21 miRanda;miRNATAP -0.117519522758293 0.000189612052071907 NA NA NA hsa-miR-505-3p SCG2 -0.530462599544864 7.71645736541597e-05 1.91907745779374 2.47137768211596e-21 MirTarget -0.236295239879281 7.37841307917154e-06 NA NA NA hsa-miR-10b-5p SDC1 -2.10996264627796 7.36811595736367e-72 2.40368042487631 4.37964429167287e-49 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.400756246291133 9.49557290109306e-19 22573479 In breast cancer overexpression of the transmembrane heparan sulfate proteoglycan syndecan-1 a predicted target of the oncomiR miR-10b correlates with poor clinical outcome; To investigate the potential functional relationship of miR-10b and syndecan-1 MDA-MB-231 and MCF-7 breast cancer cells were transiently transfected with pre-miR-10b syndecan-1 siRNA or control reagents respectively; miR-10b overexpression induced post-transcriptional downregulation of syndecan-1 as demonstrated by quantitative real-time PCR qPCR flow cytometry and 3'UTR luciferase assays resulting in increased cancer cell migration and matrigel invasiveness; We conclude that syndecan-1 is a novel target of the oncomiR miR-10b cell migration breast cancer hsa-miR-125a-5p SDC1 -0.635694700253268 3.6703235721638e-11 2.40368042487631 4.37964429167287e-49 mirMAP -0.257497428061822 2.69263717629505e-05 NA NA NA hsa-miR-338-3p SDC1 0.0799903526884966 0.575137668326679 2.40368042487631 4.37964429167287e-49 miRanda -0.214375651226656 2.46642565158765e-07 NA NA NA hsa-miR-339-5p SDC1 -0.211548290465418 0.0685885445822389 2.40368042487631 4.37964429167287e-49 miRanda -0.161324383433201 0.0016746938448849 NA NA NA hsa-miR-486-5p SDC1 -3.87258704301474 1.22658629378451e-80 2.40368042487631 4.37964429167287e-49 miRanda -0.368421700706251 6.65137792846804e-50 NA NA NA hsa-miR-491-5p SDC1 -1.04307210952796 1.14586501470398e-15 2.40368042487631 4.37964429167287e-49 miRanda -0.266012535218907 3.18139062569872e-09 NA NA NA hsa-miR-130a-3p SDC4 -1.15024914519431 6.51290317952496e-19 0.338332926801772 0.000350382576050452 MirTarget -0.129401870016198 1.20279834772162e-07 NA NA NA hsa-miR-130b-3p SDC4 1.38122163823846 1.00932179737836e-26 0.338332926801772 0.000350382576050452 MirTarget -0.110137350286151 6.77360403200533e-06 NA NA NA hsa-miR-140-3p SDC4 -1.25844395244141 5.29222651039892e-33 0.338332926801772 0.000350382576050452 MirTarget -0.100038975113085 0.000773377900187619 NA NA NA hsa-miR-18a-5p SDC4 0.969066793715868 1.69069796425892e-08 0.338332926801772 0.000350382576050452 MirTarget -0.13009744301677 2.38243911448905e-12 NA NA NA hsa-miR-224-5p SDC4 -2.22249420723892 1.07787949391113e-18 0.338332926801772 0.000350382576050452 MirTarget -0.100112838718792 6.96775647086021e-16 NA NA NA hsa-miR-495-3p SDC4 -1.67685437612894 1.70634429769052e-34 0.338332926801772 0.000350382576050452 MirTarget -0.128087460274191 1.64693962845494e-08 NA NA NA hsa-miR-942-5p SDC4 0.0274758353801279 0.842368857038259 0.338332926801772 0.000350382576050452 MirTarget -0.153474186304945 5.37732746880237e-11 NA NA NA hsa-miR-30a-5p SERPINE1 -0.392489994825279 0.00954894667761676 1.12049888044954 7.60138805308414e-13 miRNATAP -0.145922595645178 4.52059974009477e-05 NA NA NA hsa-miR-30b-5p SERPINE1 -0.46540603860146 2.4709940429591e-05 1.12049888044954 7.60138805308414e-13 MirTarget -0.308253693084862 2.51129673053519e-10 25170877 miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells gastric cancer hsa-miR-30c-5p SERPINE1 -0.393222674580066 8.06961465717306e-05 1.12049888044954 7.60138805308414e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.300227762852185 2.96907430143248e-08 NA NA NA hsa-miR-30d-5p SERPINE1 -0.247082219011045 0.00406717930063148 1.12049888044954 7.60138805308414e-13 miRNATAP -0.37317010013897 3.19444120977288e-09 NA NA NA hsa-miR-30a-5p SERPINE2 -0.392489994825279 0.00954894667761676 0.48938030507455 0.000759798537006942 miRNAWalker2_validate -0.102920150225952 0.00178003825429059 NA NA NA hsa-miR-342-3p SERPINE2 1.21944481975657 6.81914373001202e-19 0.48938030507455 0.000759798537006942 miRanda -0.159241561346099 7.14025404592503e-06 NA NA NA hsa-miR-625-5p SERPINE2 0.728939236913178 5.97591217674307e-08 0.48938030507455 0.000759798537006942 MirTarget -0.110167373960008 0.00382396603754863 NA NA NA hsa-miR-26b-5p SERPINH1 -0.331527896896866 0.000551258576575092 0.883778128269425 2.63254644470443e-18 miRNAWalker2_validate -0.195361843910013 1.10599684108504e-07 NA NA NA hsa-miR-29a-3p SERPINH1 -0.699539666833076 1.13935003139957e-13 0.883778128269425 2.63254644470443e-18 miRNATAP -0.179407269560858 1.29884665074801e-06 27488440 Regulation of LOXL2 and SERPINH1 by antitumor microRNA 29a in lung cancer with idiopathic pulmonary fibrosis; Downregulation of miR-29a caused overexpression of LOXL2 and SERPINH1 in lung cancer and IPF suggesting that these genes are involved in the pathogenesis of these two diseases.Journal of Human Genetics advance online publication 4 August 2016; doi:10.1038/jhg.2016.99 staging lung cancer hsa-miR-29b-3p SERPINH1 0.438847962603729 6.46722433236121e-05 0.883778128269425 2.63254644470443e-18 miRNATAP -0.230034691731052 4.95207222090207e-13 NA NA NA hsa-miR-29c-3p SERPINH1 -0.0652732378039769 0.563774115756922 0.883778128269425 2.63254644470443e-18 miRNATAP -0.358074025516633 2.81491856609759e-32 NA NA NA hsa-miR-1301-3p SFRP1 1.80754972811286 2.96809840886499e-36 -4.57542964080819 4.43759637848337e-44 MirTarget -0.627568666111828 8.02299635565225e-16 NA NA NA hsa-miR-16-1-3p SFRP1 1.30142784811196 2.53343713753744e-29 -4.57542964080819 4.43759637848337e-44 MirTarget -0.711103027959144 8.81693153322732e-12 NA NA NA hsa-miR-182-5p SFRP1 2.36408084103818 2.60011457600281e-72 -4.57542964080819 4.43759637848337e-44 mirMAP -0.967266087949178 4.26592739938163e-34 NA NA NA hsa-miR-429 SFRP1 2.84108892259147 3.88520896426515e-64 -4.57542964080819 4.43759637848337e-44 miRNATAP -0.482539995817486 1.02848505471575e-13 NA NA NA hsa-miR-484 SFRP1 0.349444060004737 0.00154491249625173 -4.57542964080819 4.43759637848337e-44 MirTarget -0.736652971526416 5.14194951874832e-12 NA NA NA hsa-miR-625-5p SFRP1 0.728939236913178 5.97591217674307e-08 -4.57542964080819 4.43759637848337e-44 MirTarget -0.628996046116407 2.3830320131247e-12 NA NA NA hsa-miR-7-1-3p SFRP1 0.686579567507582 1.20731554448806e-07 -4.57542964080819 4.43759637848337e-44 MirTarget;mirMAP -0.630150561051086 2.75485010272039e-12 NA NA NA hsa-miR-96-5p SFRP1 3.24596558166606 1.92296159041707e-98 -4.57542964080819 4.43759637848337e-44 mirMAP -0.844516363711542 6.21667681893678e-38 NA NA NA hsa-miR-3607-3p SFRP4 0.00697875745616461 0.972073275173643 -0.600105446413612 0.00305552026524159 MirTarget -0.118981576120521 0.000643377135339091 NA NA NA hsa-miR-429 SFRP4 2.84108892259147 3.88520896426515e-64 -0.600105446413612 0.00305552026524159 miRanda -0.313049201490686 1.13859376562001e-16 NA NA NA hsa-miR-532-5p SFRP4 0.0386976222860582 0.682018574136515 -0.600105446413612 0.00305552026524159 MirTarget -0.348327615827745 2.35831438297707e-06 NA NA NA hsa-miR-155-5p SGCB 1.09766314984151 4.55650930885814e-15 -1.13558235438512 3.11926576951198e-34 miRNATAP -0.148212195360535 1.52527856885001e-10 NA NA NA hsa-miR-182-5p SGCB 2.36408084103818 2.60011457600281e-72 -1.13558235438512 3.11926576951198e-34 mirMAP -0.213074481062613 3.87855822890513e-21 NA NA NA hsa-miR-21-5p SGCB 2.32007501846389 3.08394781855554e-137 -1.13558235438512 3.11926576951198e-34 miRNAWalker2_validate -0.380361072104493 9.14013099981249e-40 NA NA NA hsa-miR-32-5p SGCB 1.38676603945192 2.29428299685976e-34 -1.13558235438512 3.11926576951198e-34 mirMAP -0.140503794625686 5.39668332756944e-07 24348862 microRNA 32 inhibits the proliferation and invasion of the SGC 7901 gastric cancer cell line in vitro gastric cancer hsa-miR-429 SGCB 2.84108892259147 3.88520896426515e-64 -1.13558235438512 3.11926576951198e-34 miRanda;miRNATAP -0.166562587898924 1.84530161414e-20 NA NA NA hsa-miR-590-3p SGCB 1.27438512890514 1.03164723481469e-23 -1.13558235438512 3.11926576951198e-34 miRNAWalker2_validate;miRanda;mirMAP -0.116119139773766 1.2533322296895e-05 NA NA NA hsa-let-7d-5p SGCD 0.410958462607207 6.07808182756787e-06 -1.03490447383629 2.87494382883947e-10 miRNATAP -0.36912761416062 2.85169522103717e-09 NA NA NA hsa-let-7g-5p SGCD 0.0200025784917734 0.791635298815256 -1.03490447383629 2.87494382883947e-10 miRNATAP -0.370530747346917 9.36955162806493e-07 NA NA NA hsa-miR-103a-3p SGCD 0.610673390034345 1.63113920514646e-12 -1.03490447383629 2.87494382883947e-10 mirMAP -0.564862781268354 1.05885612091173e-18 NA NA NA hsa-miR-106a-5p SGCD 0.574594373206545 0.000145868284001732 -1.03490447383629 2.87494382883947e-10 mirMAP -0.230947716517431 5.19331902860737e-10 NA NA NA hsa-miR-106b-5p SGCD 1.22477789913175 2.31787213143326e-32 -1.03490447383629 2.87494382883947e-10 mirMAP -0.688579980031158 1.43263463042611e-42 NA NA NA hsa-miR-107 SGCD 0.678998026350662 2.56224148930538e-16 -1.03490447383629 2.87494382883947e-10 mirMAP -0.602559950439126 1.10105969887212e-19 NA NA NA hsa-miR-130b-5p SGCD 1.0573161199584 2.55177349228739e-12 -1.03490447383629 2.87494382883947e-10 mirMAP -0.206522962036673 2.20837956218943e-08 NA NA NA hsa-miR-142-5p SGCD 1.16509303143593 1.96641162209073e-13 -1.03490447383629 2.87494382883947e-10 miRNATAP -0.207388543579804 3.37372447580184e-09 NA NA NA hsa-miR-146a-5p SGCD 0.102405752365098 0.486975378688068 -1.03490447383629 2.87494382883947e-10 mirMAP -0.204897149257882 9.69565920592112e-08 NA NA NA hsa-miR-146b-5p SGCD 0.631041661167954 6.20366593452965e-08 -1.03490447383629 2.87494382883947e-10 mirMAP -0.277406957274555 8.46722870452066e-09 NA NA NA hsa-miR-148a-5p SGCD 0.572692271754695 2.14306251522796e-06 -1.03490447383629 2.87494382883947e-10 mirMAP -0.296834149803238 1.65056239792116e-10 NA NA NA hsa-miR-15a-5p SGCD 0.812445324157528 4.50263417099822e-20 -1.03490447383629 2.87494382883947e-10 miRNATAP -0.593127870063114 5.63081086119932e-22 NA NA NA hsa-miR-15b-5p SGCD 0.788659356634696 1.13678211092534e-11 -1.03490447383629 2.87494382883947e-10 miRNATAP -0.407815348110974 9.51839210998922e-18 NA NA NA hsa-miR-16-2-3p SGCD 0.286355254959005 0.0256946046884474 -1.03490447383629 2.87494382883947e-10 mirMAP -0.415152863620702 1.59806481817468e-21 NA NA NA hsa-miR-16-5p SGCD 0.46835991343556 1.91125356547776e-06 -1.03490447383629 2.87494382883947e-10 miRNATAP -0.415521462248694 3.10142051340814e-13 NA NA NA hsa-miR-17-5p SGCD 0.599531757298529 1.07318660415906e-05 -1.03490447383629 2.87494382883947e-10 mirMAP -0.501129749961428 2.57993646636158e-36 NA NA NA hsa-miR-19a-3p SGCD 0.817507952171848 3.76285090469625e-08 -1.03490447383629 2.87494382883947e-10 mirMAP -0.448555757138211 7.83755360777823e-35 NA NA NA hsa-miR-19b-3p SGCD 0.139124391010031 0.255658553872934 -1.03490447383629 2.87494382883947e-10 mirMAP -0.469111352920789 3.50190654314722e-25 NA NA NA hsa-miR-200b-3p SGCD 2.11744072703209 1.66710572104191e-43 -1.03490447383629 2.87494382883947e-10 mirMAP -0.34826142665604 2.52588558152801e-24 NA NA NA hsa-miR-200c-3p SGCD 2.07038651806183 6.84613386286599e-51 -1.03490447383629 2.87494382883947e-10 mirMAP -0.428620938419301 1.60025150088249e-30 NA NA NA hsa-miR-20a-5p SGCD 0.44979911120222 0.000602386964327228 -1.03490447383629 2.87494382883947e-10 mirMAP -0.544990555239578 8.59429838985871e-40 NA NA NA hsa-miR-20b-5p SGCD 0.78236583455125 8.7938334801223e-05 -1.03490447383629 2.87494382883947e-10 mirMAP -0.13357151865193 2.32111607786799e-06 NA NA NA hsa-miR-21-3p SGCD 2.17476065946878 5.15299442583591e-75 -1.03490447383629 2.87494382883947e-10 mirMAP -0.124901327450751 0.00423892545819726 NA NA NA hsa-miR-25-3p SGCD -0.00546790775985073 0.944061771389468 -1.03490447383629 2.87494382883947e-10 mirMAP -0.666661257309335 2.16772821760806e-20 NA NA NA hsa-miR-29a-5p SGCD 0.334183773952055 0.00445137265870197 -1.03490447383629 2.87494382883947e-10 mirMAP -0.254807326197304 1.32024612849983e-07 NA NA NA hsa-miR-29b-1-5p SGCD 0.0164831140865254 0.909727358526678 -1.03490447383629 2.87494382883947e-10 mirMAP -0.110319354602869 0.00510258216906872 NA NA NA hsa-miR-30d-3p SGCD 0.264544633563642 0.00755023189129747 -1.03490447383629 2.87494382883947e-10 mirMAP -0.407416233995784 8.30085551482544e-13 NA NA NA hsa-miR-32-5p SGCD 1.38676603945192 2.29428299685976e-34 -1.03490447383629 2.87494382883947e-10 mirMAP -0.436982506640723 1.67647316855048e-20 NA NA NA hsa-miR-331-5p SGCD 0.682437632502949 4.10871642662371e-11 -1.03490447383629 2.87494382883947e-10 mirMAP -0.389911400034772 5.35466547347595e-13 NA NA NA hsa-miR-339-5p SGCD -0.211548290465418 0.0685885445822389 -1.03490447383629 2.87494382883947e-10 PITA;miRNATAP -0.236765832744237 1.25902732277366e-06 NA NA NA hsa-miR-33a-5p SGCD 1.35185127289399 9.80509199125785e-12 -1.03490447383629 2.87494382883947e-10 mirMAP;miRNATAP -0.200682313665503 1.85419342248083e-12 NA NA NA hsa-miR-361-5p SGCD -0.0996867547900457 0.095428250126326 -1.03490447383629 2.87494382883947e-10 miRNATAP -0.458845568184863 1.91978933082544e-06 NA NA NA hsa-miR-429 SGCD 2.84108892259147 3.88520896426515e-64 -1.03490447383629 2.87494382883947e-10 mirMAP -0.318206488597772 1.84039361156199e-25 NA NA NA hsa-miR-500a-5p SGCD 0.209805801129289 0.119177819862398 -1.03490447383629 2.87494382883947e-10 mirMAP -0.352919664865515 5.24688686481856e-17 NA NA NA hsa-miR-532-5p SGCD 0.0386976222860582 0.682018574136515 -1.03490447383629 2.87494382883947e-10 PITA -0.475398220421397 1.50256821176779e-15 NA NA NA hsa-miR-576-5p SGCD 0.0649387707567879 0.588791966096287 -1.03490447383629 2.87494382883947e-10 mirMAP -0.299151208032467 2.01748089836749e-10 NA NA NA hsa-miR-589-3p SGCD 0.0263457630961427 0.866577983997705 -1.03490447383629 2.87494382883947e-10 mirMAP -0.13278740615385 0.000344670145413074 NA NA NA hsa-miR-590-3p SGCD 1.27438512890514 1.03164723481469e-23 -1.03490447383629 2.87494382883947e-10 PITA;miRanda;mirMAP;miRNATAP -0.462850191307795 1.37315225697568e-25 NA NA NA hsa-miR-590-5p SGCD 0.746515607868274 8.51300479640125e-09 -1.03490447383629 2.87494382883947e-10 miRanda -0.414382482482561 1.74332250019249e-22 NA NA NA hsa-miR-625-3p SGCD 0.0779480073849017 0.444334811113011 -1.03490447383629 2.87494382883947e-10 mirMAP -0.145351947975835 0.00957213556768311 NA NA NA hsa-miR-7-1-3p SGCD 0.686579567507582 1.20731554448806e-07 -1.03490447383629 2.87494382883947e-10 mirMAP -0.24177104886905 2.33466257839842e-08 NA NA NA hsa-miR-9-5p SGCD 0.734772328078424 0.00261982843636383 -1.03490447383629 2.87494382883947e-10 mirMAP;miRNATAP -0.153998869234431 2.00625419014492e-11 NA NA NA hsa-miR-92a-3p SGCD -0.342420481092807 0.000732275969501111 -1.03490447383629 2.87494382883947e-10 mirMAP -0.516828141210068 4.57248560684236e-21 NA NA NA hsa-miR-93-5p SGCD 1.01788600209314 1.24312921618126e-21 -1.03490447383629 2.87494382883947e-10 mirMAP -0.685689528668329 1.17294845087635e-43 NA NA NA hsa-miR-590-3p SGCG 1.27438512890514 1.03164723481469e-23 -4.30592633336607 7.81091892407564e-53 miRanda -0.667322515236336 2.19449908203286e-16 NA NA NA hsa-miR-590-5p SGCG 0.746515607868274 8.51300479640125e-09 -4.30592633336607 7.81091892407564e-53 miRanda -0.601352687982167 1.11600831627453e-14 NA NA NA hsa-miR-218-5p SLC6A8 -1.02621788318234 2.9221925445771e-23 0.330454417813347 0.00437492077011121 mirMAP -0.216004007605428 7.15110904620379e-09 NA NA NA hsa-miR-654-3p SLC6A8 -1.20494927978695 4.07682448923698e-16 0.330454417813347 0.00437492077011121 PITA -0.101242960497948 0.000122387226391454 NA NA NA hsa-miR-200b-3p SLIT2 2.11744072703209 1.66710572104191e-43 -1.96479460453985 2.09695722427889e-22 TargetScan -0.431271705406123 6.75929574300841e-24 NA NA NA hsa-miR-330-3p SLIT2 0.432728362037032 0.00041335506960812 -1.96479460453985 2.09695722427889e-22 miRNAWalker2_validate -0.25389733209477 1.45307145719117e-05 NA NA NA hsa-miR-576-5p SLIT2 0.0649387707567879 0.588791966096287 -1.96479460453985 2.09695722427889e-22 mirMAP -0.178282643172975 0.00265074852649693 NA NA NA hsa-miR-590-3p SLIT2 1.27438512890514 1.03164723481469e-23 -1.96479460453985 2.09695722427889e-22 miRanda -0.489728797678989 1.76391274587599e-18 NA NA NA hsa-miR-664a-3p SLIT2 -0.237699857923843 0.0197071390183375 -1.96479460453985 2.09695722427889e-22 mirMAP -0.200048652311614 0.00423563381740349 NA NA NA hsa-miR-130b-3p SLIT3 1.38122163823846 1.00932179737836e-26 -2.26432098697292 2.92136586837965e-51 mirMAP -0.426031790641379 3.8924043940584e-26 NA NA NA hsa-miR-130b-5p SLIT3 1.0573161199584 2.55177349228739e-12 -2.26432098697292 2.92136586837965e-51 mirMAP -0.295591000591932 5.30852067369309e-17 NA NA NA hsa-miR-148a-5p SLIT3 0.572692271754695 2.14306251522796e-06 -2.26432098697292 2.92136586837965e-51 MirTarget;miRNATAP -0.268689175620955 2.28947194201368e-09 NA NA NA hsa-miR-16-2-3p SLIT3 0.286355254959005 0.0256946046884474 -2.26432098697292 2.92136586837965e-51 mirMAP -0.338580874592402 1.50948387189921e-15 NA NA NA hsa-miR-192-5p SLIT3 1.33366224451777 9.5116159697107e-29 -2.26432098697292 2.92136586837965e-51 mirMAP -0.485177385583589 9.64247368949977e-30 NA NA NA hsa-miR-1976 SLIT3 0.289190368864725 0.00167092758216584 -2.26432098697292 2.92136586837965e-51 mirMAP -0.270643641754147 5.89735183123883e-06 NA NA NA hsa-miR-200c-5p SLIT3 1.72523090857052 4.04399802119594e-33 -2.26432098697292 2.92136586837965e-51 mirMAP -0.480724035054558 1.10092212226544e-40 NA NA NA hsa-miR-301a-3p SLIT3 1.32170168375632 2.12280368957514e-15 -2.26432098697292 2.92136586837965e-51 mirMAP -0.358049576171984 6.59847190887378e-30 NA NA NA hsa-miR-330-3p SLIT3 0.432728362037032 0.00041335506960812 -2.26432098697292 2.92136586837965e-51 mirMAP -0.221864397039064 9.33623668748779e-07 NA NA NA hsa-miR-330-5p SLIT3 0.626063225953928 3.42215028606779e-09 -2.26432098697292 2.92136586837965e-51 miRanda;mirMAP -0.373850486103042 2.05859090886874e-13 NA NA NA hsa-miR-362-5p SLIT3 -0.248676340901797 0.0726089851456282 -2.26432098697292 2.92136586837965e-51 TargetScan -0.167353349401651 2.38858539069731e-05 NA NA NA hsa-miR-3913-5p SLIT3 0.71890413546147 2.61153227160465e-13 -2.26432098697292 2.92136586837965e-51 mirMAP -0.243834358039105 1.02468382041708e-05 NA NA NA hsa-miR-429 SLIT3 2.84108892259147 3.88520896426515e-64 -2.26432098697292 2.92136586837965e-51 miRNATAP -0.412659633647214 5.82358018683184e-47 NA NA NA hsa-miR-454-3p SLIT3 1.28177672191095 6.84024979484587e-21 -2.26432098697292 2.92136586837965e-51 mirMAP -0.425391555171681 8.55395908218195e-29 NA NA NA hsa-miR-500a-5p SLIT3 0.209805801129289 0.119177819862398 -2.26432098697292 2.92136586837965e-51 mirMAP -0.249351910899481 1.30679823631919e-09 NA NA NA hsa-miR-590-3p SLIT3 1.27438512890514 1.03164723481469e-23 -2.26432098697292 2.92136586837965e-51 miRanda;mirMAP -0.528597525756374 5.46215889593109e-36 NA NA NA hsa-miR-590-5p SLIT3 0.746515607868274 8.51300479640125e-09 -2.26432098697292 2.92136586837965e-51 miRanda -0.477978043456429 4.36387222890957e-32 NA NA NA hsa-miR-625-5p SLIT3 0.728939236913178 5.97591217674307e-08 -2.26432098697292 2.92136586837965e-51 mirMAP -0.232933522013029 2.22946641399951e-08 NA NA NA hsa-miR-9-5p SLIT3 0.734772328078424 0.00261982843636383 -2.26432098697292 2.92136586837965e-51 mirMAP -0.176488453856042 1.29788226038472e-15 NA NA NA hsa-miR-96-5p SLIT3 3.24596558166606 1.92296159041707e-98 -2.26432098697292 2.92136586837965e-51 TargetScan -0.441828765991714 1.19052500151293e-49 NA NA NA hsa-miR-99b-3p SLIT3 0.617175730947012 6.04327581183627e-09 -2.26432098697292 2.92136586837965e-51 mirMAP -0.292198918392787 1.10661748568894e-08 NA NA NA hsa-miR-107 SNAI2 0.678998026350662 2.56224148930538e-16 -0.929098872578741 6.81961748391463e-14 miRanda -0.375468335579203 1.4407813113722e-13 NA NA NA hsa-miR-148b-3p SNAI2 1.0552576751879 1.6679285705231e-29 -0.929098872578741 6.81961748391463e-14 miRNAWalker2_validate -0.35950918837567 2.88411069877523e-16 NA NA NA hsa-miR-182-5p SNAI2 2.36408084103818 2.60011457600281e-72 -0.929098872578741 6.81961748391463e-14 miRNAWalker2_validate;miRNATAP -0.310945077672776 1.14998297831868e-26 NA NA NA hsa-miR-200b-3p SNAI2 2.11744072703209 1.66710572104191e-43 -0.929098872578741 6.81961748391463e-14 TargetScan -0.244585452671317 7.0648050194561e-21 NA NA NA hsa-miR-200c-3p SNAI2 2.07038651806183 6.84613386286599e-51 -0.929098872578741 6.81961748391463e-14 miRNATAP -0.286974732040298 1.03468820627389e-23 NA NA NA hsa-miR-330-3p SNAI2 0.432728362037032 0.00041335506960812 -0.929098872578741 6.81961748391463e-14 PITA -0.131931156476665 0.000213082977743384 NA NA NA hsa-miR-375 SNAI2 2.09893673049766 1.68351780396203e-16 -0.929098872578741 6.81961748391463e-14 miRanda -0.147761834840226 9.62714562907298e-20 NA NA NA hsa-miR-429 SNAI2 2.84108892259147 3.88520896426515e-64 -0.929098872578741 6.81961748391463e-14 PITA;miRanda;miRNATAP -0.220374529254888 3.02724246604925e-21 NA NA NA hsa-miR-590-3p SNAI2 1.27438512890514 1.03164723481469e-23 -0.929098872578741 6.81961748391463e-14 PITA;miRanda;mirMAP -0.184741712755568 7.85062670862328e-08 NA NA NA hsa-miR-96-5p SNAI2 3.24596558166606 1.92296159041707e-98 -0.929098872578741 6.81961748391463e-14 miRNATAP -0.280366193015972 1.4231591750163e-31 NA NA NA hsa-miR-664a-3p SNTB1 -0.237699857923843 0.0197071390183375 -0.903174462743841 4.56397465776127e-16 MirTarget -0.100815210299407 0.00833416973116649 NA NA NA hsa-miR-192-5p SPARC 1.33366224451777 9.5116159697107e-29 0.260111874990256 0.034213916848521 miRNAWalker2_validate -0.202574324774803 1.85477739788663e-09 NA NA NA hsa-miR-19a-3p SPARC 0.817507952171848 3.76285090469625e-08 0.260111874990256 0.034213916848521 mirMAP -0.268118147024138 1.38098125523909e-22 NA NA NA hsa-miR-29a-3p SPARC -0.699539666833076 1.13935003139957e-13 0.260111874990256 0.034213916848521 miRNAWalker2_validate;miRTarBase;miRNATAP -0.276490711012334 2.81122571776633e-10 23023935 microRNA 29a suppresses cell proliferation by targeting SPARC in hepatocellular carcinoma; Dual-luciferase reporter assays indicated that the SPARC mRNA 3'UTR was directly targeted by miR-29a since the mutated 3'UTR was not affected; Silencing SPARC expression by RNAi knockdown resulted in a similar effect as miR-29a overexpression on hepatocellular carcinoma HCC cell growth regulation liver cancer hsa-miR-29b-3p SPARC 0.438847962603729 6.46722433236121e-05 0.260111874990256 0.034213916848521 miRNATAP -0.384395891622451 5.30382002722721e-25 NA NA NA hsa-miR-29c-3p SPARC -0.0652732378039769 0.563774115756922 0.260111874990256 0.034213916848521 miRNAWalker2_validate;miRTarBase;miRNATAP -0.236782195478602 1.58903743028344e-10 NA NA NA hsa-miR-345-5p SPARC 0.639728356429512 0.00013070715719672 0.260111874990256 0.034213916848521 MirTarget -0.101607814735139 4.91473064761054e-05 NA NA NA hsa-miR-361-5p SPARC -0.0996867547900457 0.095428250126326 0.260111874990256 0.034213916848521 MirTarget -0.206927045407168 0.00387884924849876 NA NA NA hsa-miR-362-5p SPARC -0.248676340901797 0.0726089851456282 0.260111874990256 0.034213916848521 TargetScan -0.168291539744716 2.57990725792833e-08 NA NA NA hsa-miR-532-3p SPARC -0.395473145042459 0.00686714288452761 0.260111874990256 0.034213916848521 miRNATAP -0.158714718071779 2.78550881091772e-08 NA NA NA hsa-miR-625-5p SPARC 0.728939236913178 5.97591217674307e-08 0.260111874990256 0.034213916848521 MirTarget -0.125075683930636 9.54189593529796e-05 NA NA NA hsa-miR-7-1-3p SPARC 0.686579567507582 1.20731554448806e-07 0.260111874990256 0.034213916848521 mirMAP -0.205409383764211 1.29686490246239e-10 NA NA NA hsa-let-7a-3p SPOCK1 0.466622567891891 3.70886257943079e-07 0.314214907825931 0.0640142664939813 mirMAP -0.172170233538025 0.00653410564867866 NA NA NA hsa-miR-148a-5p SPOCK1 0.572692271754695 2.14306251522796e-06 0.314214907825931 0.0640142664939813 mirMAP -0.252456105188833 1.19206724490914e-07 NA NA NA hsa-miR-16-1-3p SPOCK1 1.30142784811196 2.53343713753744e-29 0.314214907825931 0.0640142664939813 MirTarget -0.233318347783166 5.39117511783295e-06 NA NA NA hsa-miR-19a-3p SPOCK1 0.817507952171848 3.76285090469625e-08 0.314214907825931 0.0640142664939813 MirTarget -0.342062924203204 2.37143128997412e-19 NA NA NA hsa-miR-19b-3p SPOCK1 0.139124391010031 0.255658553872934 0.314214907825931 0.0640142664939813 MirTarget -0.450972911293736 2.79718342356724e-22 NA NA NA hsa-miR-26a-5p SPOCK1 -0.481180084102235 1.82368246174758e-10 0.314214907825931 0.0640142664939813 mirMAP -0.286063266936653 0.000195949263685073 NA NA NA hsa-miR-301a-3p SPOCK1 1.32170168375632 2.12280368957514e-15 0.314214907825931 0.0640142664939813 MirTarget -0.134531525861579 9.52483460549975e-05 NA NA NA hsa-miR-30d-3p SPOCK1 0.264544633563642 0.00755023189129747 0.314214907825931 0.0640142664939813 mirMAP -0.4118480202134 1.53962685537638e-12 NA NA NA hsa-miR-429 SPOCK1 2.84108892259147 3.88520896426515e-64 0.314214907825931 0.0640142664939813 miRNATAP -0.172376870667441 6.78229635149319e-08 NA NA NA hsa-miR-454-3p SPOCK1 1.28177672191095 6.84024979484587e-21 0.314214907825931 0.0640142664939813 MirTarget -0.150122278793399 0.000324181129254843 NA NA NA hsa-miR-501-3p SPOCK1 0.0448022813406874 0.711710441403614 0.314214907825931 0.0640142664939813 PITA;TargetScan;miRNATAP -0.166625552216923 0.000531372280603243 NA NA NA hsa-miR-502-3p SPOCK1 0.11461741546458 0.276553832470138 0.314214907825931 0.0640142664939813 PITA;miRNATAP -0.301354114785672 4.59705942691526e-08 NA NA NA hsa-miR-590-3p SPOCK1 1.27438512890514 1.03164723481469e-23 0.314214907825931 0.0640142664939813 PITA;miRanda;mirMAP -0.286463476661966 5.70968300034788e-10 NA NA NA hsa-miR-590-5p SPOCK1 0.746515607868274 8.51300479640125e-09 0.314214907825931 0.0640142664939813 MirTarget;miRanda;mirMAP -0.286552317916135 8.29050732471913e-11 NA NA NA hsa-miR-625-5p SPOCK1 0.728939236913178 5.97591217674307e-08 0.314214907825931 0.0640142664939813 MirTarget -0.140956794202996 0.00147781409273436 NA NA NA hsa-miR-671-5p SPOCK1 1.55248047544015 7.7377784125886e-33 0.314214907825931 0.0640142664939813 MirTarget;PITA -0.245164003071068 1.79060180602905e-08 NA NA NA hsa-miR-769-5p SPOCK1 0.564871766265874 8.16695101656941e-10 0.314214907825931 0.0640142664939813 PITA -0.27642965244483 1.05137921586764e-05 NA NA NA hsa-miR-139-5p SPP1 -3.25846663863766 2.62018989415003e-112 2.26670631164277 1.22530665713086e-25 miRanda -0.500352860676903 2.02284408020613e-29 NA NA NA hsa-miR-335-5p SPP1 -2.61355235628987 2.6462884165886e-51 2.26670631164277 1.22530665713086e-25 miRNAWalker2_validate -0.324190847145869 2.06671050183243e-15 NA NA NA hsa-miR-34c-5p SPP1 -0.0896438810345765 0.557016551646841 2.26670631164277 1.22530665713086e-25 miRanda -0.285906011260852 1.12986821005389e-08 NA NA NA hsa-miR-128-3p TAGLN 0.90296715955238 9.925204823863e-23 -1.31903092970368 6.33534119713488e-23 miRNAWalker2_validate -0.380608984042769 1.25859375645886e-14 NA NA NA hsa-miR-193a-3p TAGLN 0.310617999804917 0.00477640270974957 -1.31903092970368 6.33534119713488e-23 miRanda -0.150118980447698 0.000457994555635169 NA NA NA hsa-miR-625-5p TAGLN 0.728939236913178 5.97591217674307e-08 -1.31903092970368 6.33534119713488e-23 mirMAP -0.301568462790841 1.24454593879789e-17 NA NA NA hsa-miR-106b-5p TFPI2 1.22477789913175 2.31787213143326e-32 -2.32786537348743 2.64841359848798e-14 miRNATAP -0.325446410421939 0.00104380519659222 NA NA NA hsa-miR-23a-3p TFPI2 -0.217176729033818 0.00962615056202409 -2.32786537348743 2.64841359848798e-14 MirTarget;miRNATAP -0.333211805921178 0.00914447010341885 NA NA NA hsa-miR-590-3p TFPI2 1.27438512890514 1.03164723481469e-23 -2.32786537348743 2.64841359848798e-14 miRanda -0.340257963205482 6.51954782076355e-05 NA NA NA hsa-miR-744-5p TGFB1 0.114590984077262 0.312916425462546 0.9572932995293 2.60884198670166e-26 miRNAWalker2_validate;miRNATAP -0.166126823806423 2.82828117413693e-09 NA NA NA hsa-miR-30a-5p TGFBI -0.392489994825279 0.00954894667761676 0.214907485511032 0.0754790062082685 miRNAWalker2_validate -0.231893521338086 5.16615908849822e-18 NA NA NA hsa-miR-34c-5p TGFBI -0.0896438810345765 0.557016551646841 0.214907485511032 0.0754790062082685 miRanda -0.103967093711939 0.000134447333002647 NA NA NA hsa-let-7d-5p TGFBR3 0.410958462607207 6.07808182756787e-06 -3.32389218515653 1.82193869897655e-62 MirTarget -0.439198520543151 5.72224800725762e-08 NA NA NA hsa-miR-103a-3p TGFBR3 0.610673390034345 1.63113920514646e-12 -3.32389218515653 1.82193869897655e-62 MirTarget;miRNATAP -0.569527730200402 1.17017523386274e-11 NA NA NA hsa-miR-107 TGFBR3 0.678998026350662 2.56224148930538e-16 -3.32389218515653 1.82193869897655e-62 MirTarget;PITA;miRanda;miRNATAP -0.734117556175882 2.20770569279332e-17 NA NA NA hsa-miR-15a-5p TGFBR3 0.812445324157528 4.50263417099822e-20 -3.32389218515653 1.82193869897655e-62 MirTarget;miRNATAP -0.561713083527093 4.2526158408029e-12 NA NA NA hsa-miR-15b-5p TGFBR3 0.788659356634696 1.13678211092534e-11 -3.32389218515653 1.82193869897655e-62 MirTarget;miRNATAP -0.403302389743106 1.00440113335679e-10 NA NA NA hsa-miR-16-2-3p TGFBR3 0.286355254959005 0.0256946046884474 -3.32389218515653 1.82193869897655e-62 mirMAP -0.253439824775358 1.17767191884621e-05 NA NA NA hsa-miR-16-5p TGFBR3 0.46835991343556 1.91125356547776e-06 -3.32389218515653 1.82193869897655e-62 MirTarget;miRNATAP -0.274012468065407 0.000257252125639833 NA NA NA hsa-miR-181a-5p TGFBR3 0.635863607630183 6.72486918157744e-11 -3.32389218515653 1.82193869897655e-62 miRNAWalker2_validate;mirMAP;miRNATAP -0.522295766789695 2.29656875506993e-12 NA NA NA hsa-miR-181b-5p TGFBR3 1.22749257795094 1.21998198830919e-27 -3.32389218515653 1.82193869897655e-62 mirMAP -0.58784175092072 2.9816417655165e-21 NA NA NA hsa-miR-181c-5p TGFBR3 0.574847839298605 4.51287502066478e-07 -3.32389218515653 1.82193869897655e-62 mirMAP;miRNATAP -0.187604205923213 0.00370461029768357 NA NA NA hsa-miR-182-5p TGFBR3 2.36408084103818 2.60011457600281e-72 -3.32389218515653 1.82193869897655e-62 miRNATAP -0.483801057258478 4.85727221592697e-22 NA NA NA hsa-miR-185-3p TGFBR3 0.86591374114446 7.8790769678542e-10 -3.32389218515653 1.82193869897655e-62 MirTarget;miRNATAP -0.435274237521705 4.94095394537297e-17 NA NA NA hsa-miR-18a-5p TGFBR3 0.969066793715868 1.69069796425892e-08 -3.32389218515653 1.82193869897655e-62 MirTarget -0.374834046066299 3.17870910707835e-19 NA NA NA hsa-miR-193a-3p TGFBR3 0.310617999804917 0.00477640270974957 -3.32389218515653 1.82193869897655e-62 MirTarget;miRanda;miRNATAP -0.374767586437559 2.03287587677141e-08 NA NA NA hsa-miR-193b-3p TGFBR3 -0.0550374855074773 0.65382485898551 -3.32389218515653 1.82193869897655e-62 miRNAWalker2_validate;MirTarget;miRNATAP -0.186820875842115 0.0019766522871598 NA NA NA hsa-miR-21-5p TGFBR3 2.32007501846389 3.08394781855554e-137 -3.32389218515653 1.82193869897655e-62 miRNAWalker2_validate -0.991051228961082 2.79000222280721e-56 NA NA NA hsa-miR-27a-3p TGFBR3 0.388496361379095 1.42373532086331e-05 -3.32389218515653 1.82193869897655e-62 MirTarget;miRNATAP -0.496255147155376 1.44393344498262e-09 NA NA NA hsa-miR-340-5p TGFBR3 1.0857159627596 4.94471062546756e-24 -3.32389218515653 1.82193869897655e-62 mirMAP -0.42416250121787 1.79630806311485e-10 NA NA NA hsa-miR-34a-5p TGFBR3 0.129201805242403 0.133261654068224 -3.32389218515653 1.82193869897655e-62 miRNATAP -0.3386975349782 8.74095048637456e-05 NA NA NA hsa-miR-429 TGFBR3 2.84108892259147 3.88520896426515e-64 -3.32389218515653 1.82193869897655e-62 miRanda -0.442656446217992 3.4698799235337e-29 NA NA NA hsa-miR-484 TGFBR3 0.349444060004737 0.00154491249625173 -3.32389218515653 1.82193869897655e-62 MirTarget;miRNATAP -0.298872428283614 7.72104729838216e-06 NA NA NA hsa-miR-501-3p TGFBR3 0.0448022813406874 0.711710441403614 -3.32389218515653 1.82193869897655e-62 TargetScan;miRNATAP -0.199474094731473 0.00110848452768603 NA NA NA hsa-miR-589-3p TGFBR3 0.0263457630961427 0.866577983997705 -3.32389218515653 1.82193869897655e-62 MirTarget -0.219795417797521 4.92067980964908e-06 NA NA NA hsa-miR-590-3p TGFBR3 1.27438512890514 1.03164723481469e-23 -3.32389218515653 1.82193869897655e-62 MirTarget;miRanda;mirMAP -0.499383945875221 8.78045761639286e-18 NA NA NA hsa-miR-590-5p TGFBR3 0.746515607868274 8.51300479640125e-09 -3.32389218515653 1.82193869897655e-62 miRanda -0.428706295757895 1.56025636054314e-14 NA NA NA hsa-miR-625-5p TGFBR3 0.728939236913178 5.97591217674307e-08 -3.32389218515653 1.82193869897655e-62 MirTarget -0.186632777718756 0.000925749967151901 NA NA NA hsa-miR-7-1-3p TGFBR3 0.686579567507582 1.20731554448806e-07 -3.32389218515653 1.82193869897655e-62 mirMAP -0.297071055351894 1.33643484389629e-07 NA NA NA hsa-miR-98-5p TGFBR3 0.656336869298973 9.03113188590466e-15 -3.32389218515653 1.82193869897655e-62 MirTarget -0.625439938777484 2.29058045414307e-13 NA NA NA hsa-miR-30a-5p TGM2 -0.392489994825279 0.00954894667761676 0.564607323806141 7.49840910453432e-06 miRNAWalker2_validate -0.112891507360612 7.84310035553134e-05 NA NA NA hsa-miR-30b-3p TGM2 -0.536462824497982 2.41814659272548e-05 0.564607323806141 7.49840910453432e-06 mirMAP -0.106393826109775 0.00190329779638534 NA NA NA hsa-miR-155-5p THBS1 1.09766314984151 4.55650930885814e-15 -0.0614785645873859 0.62138763262321 miRNAWalker2_validate;mirMAP -0.133542323510001 7.64645600006924e-06 NA NA NA hsa-miR-16-1-3p THBS1 1.30142784811196 2.53343713753744e-29 -0.0614785645873859 0.62138763262321 MirTarget -0.140131478293771 0.000198601030104097 NA NA NA hsa-miR-17-5p THBS1 0.599531757298529 1.07318660415906e-05 -0.0614785645873859 0.62138763262321 miRNAWalker2_validate -0.211166755871651 7.35327505985432e-12 NA NA NA hsa-miR-181a-5p THBS1 0.635863607630183 6.72486918157744e-11 -0.0614785645873859 0.62138763262321 mirMAP -0.150019822568732 0.000545990600769292 NA NA NA hsa-miR-181b-5p THBS1 1.22749257795094 1.21998198830919e-27 -0.0614785645873859 0.62138763262321 mirMAP -0.1533233095909 2.76267327611462e-05 NA NA NA hsa-miR-181c-5p THBS1 0.574847839298605 4.51287502066478e-07 -0.0614785645873859 0.62138763262321 mirMAP -0.147290024790751 7.4630964763336e-05 NA NA NA hsa-miR-18a-5p THBS1 0.969066793715868 1.69069796425892e-08 -0.0614785645873859 0.62138763262321 MirTarget -0.181152396860618 8.69562380186631e-14 NA NA NA hsa-miR-19a-3p THBS1 0.817507952171848 3.76285090469625e-08 -0.0614785645873859 0.62138763262321 MirTarget;mirMAP -0.214042484472341 2.35179044480412e-14 NA NA NA hsa-miR-19b-3p THBS1 0.139124391010031 0.255658553872934 -0.0614785645873859 0.62138763262321 MirTarget;mirMAP -0.25361005913269 1.79395476818e-13 NA NA NA hsa-miR-20a-5p THBS1 0.44979911120222 0.000602386964327228 -0.0614785645873859 0.62138763262321 miRNAWalker2_validate -0.30952947364433 1.36418642869234e-22 NA NA NA hsa-miR-32-5p THBS1 1.38676603945192 2.29428299685976e-34 -0.0614785645873859 0.62138763262321 mirMAP -0.19932792247749 2.72222895176776e-08 NA NA NA hsa-miR-455-5p THBS1 0.284641224662773 0.0357572339594277 -0.0614785645873859 0.62138763262321 miRanda -0.181790591068211 5.96114242364848e-09 NA NA NA hsa-miR-500a-5p THBS1 0.209805801129289 0.119177819862398 -0.0614785645873859 0.62138763262321 mirMAP -0.167786316949011 1.51589228334337e-07 NA NA NA hsa-miR-590-3p THBS1 1.27438512890514 1.03164723481469e-23 -0.0614785645873859 0.62138763262321 miRanda -0.175386342682792 2.46112499417128e-07 NA NA NA hsa-miR-590-5p THBS1 0.746515607868274 8.51300479640125e-09 -0.0614785645873859 0.62138763262321 miRanda;mirMAP -0.167667995453039 2.43506908893591e-07 NA NA NA hsa-miR-671-5p THBS1 1.55248047544015 7.7377784125886e-33 -0.0614785645873859 0.62138763262321 MirTarget -0.149992236442967 2.76078556306308e-06 NA NA NA hsa-miR-92a-3p THBS1 -0.342420481092807 0.000732275969501111 -0.0614785645873859 0.62138763262321 miRNAWalker2_validate -0.236223996163107 1.60863345703223e-08 NA NA NA hsa-miR-98-5p THBS1 0.656336869298973 9.03113188590466e-15 -0.0614785645873859 0.62138763262321 miRNAWalker2_validate -0.196108417985267 8.06107193430326e-05 NA NA NA hsa-miR-106b-5p THBS2 1.22477789913175 2.31787213143326e-32 0.769808163205687 9.78636441866493e-07 MirTarget -0.302711566656831 1.58196287774772e-09 NA NA NA hsa-miR-139-5p THBS2 -3.25846663863766 2.62018989415003e-112 0.769808163205687 9.78636441866493e-07 miRanda -0.18351393710485 1.38608699702018e-08 NA NA NA hsa-miR-16-2-3p THBS2 0.286355254959005 0.0256946046884474 0.769808163205687 9.78636441866493e-07 mirMAP -0.266853998218325 2.47345099228546e-10 NA NA NA hsa-miR-17-5p THBS2 0.599531757298529 1.07318660415906e-05 0.769808163205687 9.78636441866493e-07 MirTarget;TargetScan -0.253625690199161 1.06814941199192e-10 NA NA NA hsa-miR-20a-5p THBS2 0.44979911120222 0.000602386964327228 0.769808163205687 9.78636441866493e-07 MirTarget -0.342590656166951 2.95705202030977e-17 NA NA NA hsa-miR-29a-3p THBS2 -0.699539666833076 1.13935003139957e-13 0.769808163205687 9.78636441866493e-07 MirTarget -0.330180674500405 5.19990176669046e-09 NA NA NA hsa-miR-29b-3p THBS2 0.438847962603729 6.46722433236121e-05 0.769808163205687 9.78636441866493e-07 MirTarget -0.440296132980001 7.26973369809758e-20 NA NA NA hsa-miR-29c-3p THBS2 -0.0652732378039769 0.563774115756922 0.769808163205687 9.78636441866493e-07 MirTarget -0.431990941588527 4.39914608500664e-20 NA NA NA hsa-miR-320a THBS2 -0.287921276129346 0.00141693637596294 0.769808163205687 9.78636441866493e-07 mirMAP -0.208219274662831 0.000550427836846861 NA NA NA hsa-miR-320b THBS2 0.412787504747938 0.00113457276903985 0.769808163205687 9.78636441866493e-07 mirMAP -0.124670374856683 0.00370734965981903 NA NA NA hsa-miR-335-3p THBS2 -1.88448538773649 2.09538234398335e-32 0.769808163205687 9.78636441866493e-07 MirTarget;mirMAP -0.104434722339321 0.00143160463399029 NA NA NA hsa-miR-590-3p THBS2 1.27438512890514 1.03164723481469e-23 0.769808163205687 9.78636441866493e-07 miRanda;mirMAP -0.165183001603145 0.000140989548326802 NA NA NA hsa-miR-590-5p THBS2 0.746515607868274 8.51300479640125e-09 0.769808163205687 9.78636441866493e-07 miRanda -0.184580610139702 8.27333563753023e-06 NA NA NA hsa-miR-7-1-3p THBS2 0.686579567507582 1.20731554448806e-07 0.769808163205687 9.78636441866493e-07 MirTarget;mirMAP -0.1868408017881 6.41716930046462e-06 NA NA NA hsa-miR-93-5p THBS2 1.01788600209314 1.24312921618126e-21 0.769808163205687 9.78636441866493e-07 MirTarget -0.273544363928753 3.16076912551438e-08 NA NA NA hsa-miR-125a-5p THY1 -0.635694700253268 3.6703235721638e-11 1.12483375361649 5.15475858791086e-23 miRanda -0.236450886745784 9.12994970140631e-09 NA NA NA hsa-miR-423-5p THY1 -0.0644843381453004 0.462275547464843 1.12483375361649 5.15475858791086e-23 MirTarget -0.180714928285774 8.40726508911408e-05 NA NA NA hsa-miR-744-5p THY1 0.114590984077262 0.312916425462546 1.12483375361649 5.15475858791086e-23 MirTarget -0.149425751799755 2.35435563893423e-05 NA NA NA hsa-let-7a-3p TIMP3 0.466622567891891 3.70886257943079e-07 -1.20767978742507 3.47571209381163e-18 mirMAP;miRNATAP -0.168553480085612 0.00143634561718317 NA NA NA hsa-miR-101-3p TIMP3 -0.126035286271986 0.145997832808138 -1.20767978742507 3.47571209381163e-18 miRNATAP -0.156155990378636 0.00570526518501161 NA NA NA hsa-miR-103a-3p TIMP3 0.610673390034345 1.63113920514646e-12 -1.20767978742507 3.47571209381163e-18 miRNAWalker2_validate;miRTarBase -0.40071216263977 3.55788635648772e-13 22783422 miR-103 inhibitor transfection increased the activity of the luciferase reporter assay containing the TIMP-3 3'-untranslated region UTR construct and increased the levels of the TIMP-3 protein but not its mRNA in endometrial cancer cell lines; Our data suggested that miR-103 post-transcriptionally downregulates the expression of the tumor suppressor TIMP-3 and stimulates growth and invasion in endometrial cancer cell lines endometrial cancer hsa-miR-106a-5p TIMP3 0.574594373206545 0.000145868284001732 -1.20767978742507 3.47571209381163e-18 miRNATAP -0.210647702615358 3.17059523803541e-11 NA NA NA hsa-miR-106b-5p TIMP3 1.22477789913175 2.31787213143326e-32 -1.20767978742507 3.47571209381163e-18 miRNATAP -0.585883213107748 3.99680028776433e-42 NA NA NA hsa-miR-148a-5p TIMP3 0.572692271754695 2.14306251522796e-06 -1.20767978742507 3.47571209381163e-18 mirMAP -0.377843383363986 4.41338374384476e-22 NA NA NA hsa-miR-16-1-3p TIMP3 1.30142784811196 2.53343713753744e-29 -1.20767978742507 3.47571209381163e-18 mirMAP -0.354431693839631 5.00772865266842e-17 NA NA NA hsa-miR-16-5p TIMP3 0.46835991343556 1.91125356547776e-06 -1.20767978742507 3.47571209381163e-18 miRNAWalker2_validate -0.253181989632359 2.54332103060107e-07 NA NA NA hsa-miR-181a-5p TIMP3 0.635863607630183 6.72486918157744e-11 -1.20767978742507 3.47571209381163e-18 MirTarget;miRNATAP -0.180921292940942 0.000256378364331641 NA NA NA hsa-miR-181b-5p TIMP3 1.22749257795094 1.21998198830919e-27 -1.20767978742507 3.47571209381163e-18 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.30160920404524 2.7820931137347e-13 27383203 Moreover miR-181b was found to directly target the 3' untranslated region 3'UTR of Timp3 mRNA affecting TGF-β-induced EMT gastric cancer hsa-miR-181c-5p TIMP3 0.574847839298605 4.51287502066478e-07 -1.20767978742507 3.47571209381163e-18 MirTarget;miRNATAP -0.221631478390199 1.5859420100296e-07 NA NA NA hsa-miR-181d-5p TIMP3 0.782618466877349 1.2821116358212e-09 -1.20767978742507 3.47571209381163e-18 MirTarget -0.224979236998219 1.30506551518645e-09 NA NA NA hsa-miR-20a-5p TIMP3 0.44979911120222 0.000602386964327228 -1.20767978742507 3.47571209381163e-18 miRNATAP -0.421515308652983 2.93085280341629e-32 NA NA NA hsa-miR-21-5p TIMP3 2.32007501846389 3.08394781855554e-137 -1.20767978742507 3.47571209381163e-18 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.194696613681374 9.95965481820086e-06 23936642;20346171;21820586;25720799;25587717 Genetic heterogeneity of breast cancer metastasis may be related to miR 21 regulation of TIMP 3 in translation; The aim of this study is to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis promoted breast cancer metastasis by regulating the tissue inhibitor of metalloproteinase 3 TIMP-3 gene; Correlation analysis was performed between miR-21 and TIMP-3; There was significantly inverse correlation between miR-21 and TIMP-3 extracted from tissue;The aim of this study was to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis impacts breast cancer invasion by regulating the tissue inhibitor of metalloproteinase 3 TIMP3 gene; In addition the regulation of tissue inhibitor of metalloproteinase 3 TIMP3 by miR-21 was evaluated by western blotting and luciferase assays; Evaluation of TIMP3 protein levels a peptidase involved in extarcellular matrix degredation inversely correlated with miR-21 expression; As knockdown of miR-21 increased TIMP3 protein expression and luciferase reporter activity our data suggests that miR-21 could promote invasion in breast cancer cells via its regulation of TIMP3;The effect of TIMP3 on miR-21-induced cell survival was determined by transfection with TIMP3 lacking 3' untranslated region and miR-21;We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression;It was previously shown by our group that miR-21 a potential regulator of TIMP3 is over-expressed in cutaneous melanoma; It was therefore hypothesized that increased levels of miR-21 expression would lead to decreased expression of TIMP3 and thereby enhance the invasiveness of melanoma cells; Reduced expression of TIMP3 was achieved by siRNA knockdown and significantly enhanced invasion of melanoma cell lines mimicking the effects of miR-21 over-expression; Treatment of tumor cells with a linked nucleic acid antagomir to miR-21 inhibited tumor growth and increased tumor expression of TIMP3 in vivo in 01B74 Athymic NCr-nu/nu mice; This data shows that increased expression of miR-21 enhanced the invasive potential of melanoma cell lines through TIMP3 inhibition metastasis;tumorigenesis;tumorigenesis;poor survival;metastasis;progression; breast cancer;breast cancer;kidney renal cell cancer;liver cancer;melanoma hsa-miR-221-3p TIMP3 -0.317970198201501 0.00910855267413448 -1.20767978742507 3.47571209381163e-18 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.110686937473618 0.00556740269321551 27077469 MiR 221 Exacerbate Cell Proliferation and Invasion by Targeting TIMP3 in Papillary Thyroid Carcinoma; The results indicated that miR-221 exacerbated PTC by downregulating the expression of TIMP3; The effects of miR-221 and TIMP3 in vivo were also confirmed by human PTC-bearing mice models which suggest consistent results with those in vitro studies thyroid cancer hsa-miR-30c-5p TIMP3 -0.393222674580066 8.06961465717306e-05 -1.20767978742507 3.47571209381163e-18 miRNATAP -0.140889011923866 0.00387575441830359 NA NA NA hsa-miR-30d-5p TIMP3 -0.247082219011045 0.00406717930063148 -1.20767978742507 3.47571209381163e-18 miRNATAP -0.146942025171535 0.00976336713251717 NA NA NA hsa-miR-330-3p TIMP3 0.432728362037032 0.00041335506960812 -1.20767978742507 3.47571209381163e-18 mirMAP -0.172033729081031 1.76705460156215e-05 NA NA NA hsa-miR-450b-5p TIMP3 0.781564228875267 3.90462514315383e-11 -1.20767978742507 3.47571209381163e-18 MirTarget;PITA;miRNATAP -0.122099392439636 0.00270528071108957 NA NA NA hsa-miR-505-3p TIMP3 -0.530462599544864 7.71645736541597e-05 -1.20767978742507 3.47571209381163e-18 mirMAP -0.16418911041208 5.13787208395773e-06 NA NA NA hsa-miR-590-3p TIMP3 1.27438512890514 1.03164723481469e-23 -1.20767978742507 3.47571209381163e-18 PITA;miRanda;miRNATAP -0.387543056711321 1.53246188379646e-24 NA NA NA hsa-miR-590-5p TIMP3 0.746515607868274 8.51300479640125e-09 -1.20767978742507 3.47571209381163e-18 MirTarget;PITA;miRanda;miRNATAP -0.318548384160019 2.72493683028999e-18 NA NA NA hsa-miR-660-5p TIMP3 0.406910761707485 0.000156175371762464 -1.20767978742507 3.47571209381163e-18 miRNATAP -0.430729797516085 1.37821903550253e-22 NA NA NA hsa-miR-7-1-3p TIMP3 0.686579567507582 1.20731554448806e-07 -1.20767978742507 3.47571209381163e-18 mirMAP -0.17286834955872 3.20195487653772e-06 NA NA NA hsa-miR-365a-3p TNC -1.45032725192851 2.37888098061118e-37 -0.13661350853256 0.448221214380957 MirTarget -0.138940803738652 0.00756635738729108 NA NA NA hsa-let-7e-5p TNFAIP3 0.261471269338985 0.00191077095550257 -0.384684183147111 0.000748234816409438 miRNATAP -0.191802534283467 3.92788576759362e-05 NA NA NA hsa-miR-125a-5p TNFAIP3 -0.635694700253268 3.6703235721638e-11 -0.384684183147111 0.000748234816409438 miRNAWalker2_validate;miRTarBase;miRanda -0.228989880960537 1.24180093107371e-08 NA NA NA hsa-miR-141-3p TNFAIP3 2.99777540204168 1.26370498493024e-78 -0.384684183147111 0.000748234816409438 TargetScan -0.132297814865696 1.95395162655108e-09 NA NA NA hsa-miR-429 TNFAIP3 2.84108892259147 3.88520896426515e-64 -0.384684183147111 0.000748234816409438 miRanda -0.102281354730575 2.1073153578897e-06 NA NA NA hsa-miR-181a-5p TNFRSF11B 0.635863607630183 6.72486918157744e-11 -0.837140585338879 5.84752838227966e-05 miRNATAP -0.219750716201695 0.0026283444717998 NA NA NA hsa-miR-181b-5p TNFRSF11B 1.22749257795094 1.21998198830919e-27 -0.837140585338879 5.84752838227966e-05 miRNATAP -0.22628194948355 0.000238786739997597 NA NA NA hsa-miR-200c-3p TNFRSF11B 2.07038651806183 6.84613386286599e-51 -0.837140585338879 5.84752838227966e-05 miRNATAP -0.223884434938994 4.07830474922777e-06 NA NA NA hsa-miR-21-5p TNFRSF11B 2.32007501846389 3.08394781855554e-137 -0.837140585338879 5.84752838227966e-05 miRNAWalker2_validate -0.242363243955373 0.000195848073067522 NA NA NA hsa-miR-338-3p TNFRSF11B 0.0799903526884966 0.575137668326679 -0.837140585338879 5.84752838227966e-05 miRanda -0.151187600710885 0.00264972612931679 NA NA NA hsa-miR-429 TNFRSF11B 2.84108892259147 3.88520896426515e-64 -0.837140585338879 5.84752838227966e-05 PITA;miRanda;miRNATAP -0.144379336160906 0.000261883302871321 NA NA NA hsa-miR-590-3p TNFRSF11B 1.27438512890514 1.03164723481469e-23 -0.837140585338879 5.84752838227966e-05 miRanda -0.202087674585756 0.00043077230557141 NA NA NA hsa-miR-590-5p TNFRSF11B 0.746515607868274 8.51300479640125e-09 -0.837140585338879 5.84752838227966e-05 PITA;miRanda;miRNATAP -0.205138299325131 0.000183057836722806 NA NA NA hsa-miR-16-5p TNFRSF12A 0.46835991343556 1.91125356547776e-06 1.43887307463566 6.67829109764312e-24 miRNAWalker2_validate -0.243240145563974 1.77443086986374e-06 NA NA NA hsa-miR-107 TPM1 0.678998026350662 2.56224148930538e-16 -0.358555613222972 8.37561162299271e-05 PITA;miRanda -0.304918640323759 9.93076440058766e-17 NA NA NA hsa-miR-29b-3p TPM1 0.438847962603729 6.46722433236121e-05 -0.358555613222972 8.37561162299271e-05 miRNATAP -0.119407459221293 2.66207850987115e-05 NA NA NA hsa-miR-338-3p TPM1 0.0799903526884966 0.575137668326679 -0.358555613222972 8.37561162299271e-05 miRanda -0.111279697492265 3.64370344209894e-07 NA NA NA hsa-miR-590-3p TPM1 1.27438512890514 1.03164723481469e-23 -0.358555613222972 8.37561162299271e-05 miRanda -0.11239730409644 7.12272884528486e-06 NA NA NA hsa-miR-15b-5p TPM2 0.788659356634696 1.13678211092534e-11 -0.936136387975656 8.20735781654983e-11 MirTarget -0.20621404637837 1.13382583106289e-06 NA NA NA hsa-miR-16-5p TPM2 0.46835991343556 1.91125356547776e-06 -0.936136387975656 8.20735781654983e-11 MirTarget -0.437785509868519 1.29865810646732e-18 NA NA NA hsa-miR-193a-3p TPM2 0.310617999804917 0.00477640270974957 -0.936136387975656 8.20735781654983e-11 miRanda -0.155265181341407 0.000628459160172712 NA NA NA hsa-miR-339-5p TPM2 -0.211548290465418 0.0685885445822389 -0.936136387975656 8.20735781654983e-11 miRanda -0.237982602413766 2.74265644744406e-08 NA NA NA hsa-miR-423-5p TPM2 -0.0644843381453004 0.462275547464843 -0.936136387975656 8.20735781654983e-11 miRNATAP -0.175382903029511 0.00222438836133611 NA NA NA hsa-miR-491-5p TPM2 -1.04307210952796 1.14586501470398e-15 -0.936136387975656 8.20735781654983e-11 miRanda -0.111495899585606 0.0033460286679869 NA NA NA hsa-miR-96-5p TPM2 3.24596558166606 1.92296159041707e-98 -0.936136387975656 8.20735781654983e-11 TargetScan -0.246143596727655 2.93702965075941e-18 NA NA NA hsa-miR-30d-5p TPM4 -0.247082219011045 0.00406717930063148 0.263220477756478 0.00014580922142895 miRNATAP -0.153057457337519 3.02070896322183e-08 NA NA NA hsa-miR-200a-3p VCAM1 2.55218480823434 2.96135446816238e-51 -0.422080444805657 0.00361929851720551 miRNAWalker2_validate -0.192217611764734 2.18432689837879e-12 NA NA NA hsa-miR-101-3p VCAN -0.126035286271986 0.145997832808138 1.40978286772495 4.56459858126373e-18 miRNATAP -0.37840867173635 8.35537816817371e-09 NA NA NA hsa-miR-103a-3p VCAN 0.610673390034345 1.63113920514646e-12 1.40978286772495 4.56459858126373e-18 MirTarget;miRNATAP -0.361545441851795 2.6323682790337e-08 NA NA NA hsa-miR-107 VCAN 0.678998026350662 2.56224148930538e-16 1.40978286772495 4.56459858126373e-18 MirTarget;miRanda;miRNATAP -0.189022403580585 0.00541107416209722 NA NA NA hsa-miR-16-2-3p VCAN 0.286355254959005 0.0256946046884474 1.40978286772495 4.56459858126373e-18 mirMAP -0.195430097964376 1.15996639945755e-05 NA NA NA hsa-miR-186-5p VCAN -0.426987301460247 1.04129380549315e-05 1.40978286772495 4.56459858126373e-18 MirTarget;miRNATAP -0.217399942115825 0.000213438871536315 NA NA NA hsa-miR-195-3p VCAN -1.49582726452416 6.53261924105147e-40 1.40978286772495 4.56459858126373e-18 mirMAP -0.131903512220943 0.00607391978709596 NA NA NA hsa-miR-200a-3p VCAN 2.55218480823434 2.96135446816238e-51 1.40978286772495 4.56459858126373e-18 MirTarget;miRNATAP -0.114795253898198 0.000286385738872126 NA NA NA hsa-miR-361-3p VCAN -0.0370446538644886 0.624902392829872 1.40978286772495 4.56459858126373e-18 miRNATAP -0.553320106360825 1.54531757124416e-13 NA NA NA hsa-miR-455-5p VCAN 0.284641224662773 0.0357572339594277 1.40978286772495 4.56459858126373e-18 miRanda;miRNATAP -0.138814785507525 0.000962243578613013 NA NA NA hsa-miR-664a-3p VCAN -0.237699857923843 0.0197071390183375 1.40978286772495 4.56459858126373e-18 mirMAP -0.254191822867036 5.36714909149029e-06 NA NA NA hsa-miR-101-3p VEGFA -0.126035286271986 0.145997832808138 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate -0.244521682678937 1.84891665047835e-09 NA NA NA hsa-miR-134-5p VEGFA -0.943054080774898 1.50079821035544e-12 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.167128564426745 1.10726961805336e-10 NA NA NA hsa-miR-150-5p VEGFA -0.832049526091211 3.45299201139224e-05 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate;miRTarBase -0.151371862718652 1.00198904514709e-18 NA NA NA hsa-miR-195-5p VEGFA -1.47508108420708 2.20685847368258e-38 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.218575701645509 7.55403373439709e-14 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA -0.314703593105081 0.00909304983051124 0.558196398264416 4.82412858140541e-08 miRanda;miRNATAP -0.179279483927549 6.72134651164296e-10 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA -1.37022396448377 3.25758057539223e-26 0.558196398264416 4.82412858140541e-08 miRanda -0.228409524155996 1.33793206666423e-18 NA NA NA hsa-miR-29a-3p VEGFA -0.699539666833076 1.13935003139957e-13 0.558196398264416 4.82412858140541e-08 MirTarget -0.114785243382774 0.00196474782587542 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29c-3p VEGFA -0.0652732378039769 0.563774115756922 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate;MirTarget -0.126355371943564 5.32172855437951e-05 NA NA NA hsa-miR-335-5p VEGFA -2.61355235628987 2.6462884165886e-51 0.558196398264416 4.82412858140541e-08 miRNAWalker2_validate -0.103950468396491 4.59347799365143e-08 NA NA NA hsa-miR-497-5p VEGFA -1.4667331575679 5.49909921822638e-36 0.558196398264416 4.82412858140541e-08 MirTarget -0.126722638387264 1.08881401780323e-05 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer hsa-miR-128-3p VEGFC 0.90296715955238 9.925204823863e-23 -0.815181679329146 2.46618490633351e-18 miRNAWalker2_validate;MirTarget -0.277923499247748 3.92415081523196e-16 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC 0.286355254959005 0.0256946046884474 -0.815181679329146 2.46618490633351e-18 MirTarget -0.165282903433736 7.39907917672124e-11 NA NA NA hsa-miR-590-3p VEGFC 1.27438512890514 1.03164723481469e-23 -0.815181679329146 2.46618490633351e-18 miRanda -0.194896362906364 4.34747156563496e-14 NA NA NA hsa-miR-1301-3p VIM 1.80754972811286 2.96809840886499e-36 -1.30982487912465 2.09755819189575e-37 miRNAWalker2_validate -0.193140305610759 1.04417529783299e-15 NA NA NA hsa-miR-16-5p VIM 0.46835991343556 1.91125356547776e-06 -1.30982487912465 2.09755819189575e-37 miRNAWalker2_validate -0.16029141705436 1.67854210053056e-05 NA NA NA hsa-miR-30d-5p VIM -0.247082219011045 0.00406717930063148 -1.30982487912465 2.09755819189575e-37 miRNATAP -0.177805685272395 3.37586282927736e-05 NA NA NA hsa-miR-590-3p VIM 1.27438512890514 1.03164723481469e-23 -1.30982487912465 2.09755819189575e-37 mirMAP -0.144866652800669 7.98271783488902e-07 NA NA NA hsa-miR-141-3p WIPF1 2.99777540204168 1.26370498493024e-78 -0.259862115966063 0.00927399244683076 MirTarget;TargetScan;miRNATAP -0.182826846335189 4.90344827226961e-22 NA NA NA hsa-miR-15a-5p WIPF1 0.812445324157528 4.50263417099822e-20 -0.259862115966063 0.00927399244683076 miRNAWalker2_validate -0.145169445953807 0.000129538271430198 NA NA NA hsa-miR-182-5p WIPF1 2.36408084103818 2.60011457600281e-72 -0.259862115966063 0.00927399244683076 MirTarget;miRNATAP -0.204600499940618 1.81098457609361e-18 NA NA NA hsa-miR-200a-3p WIPF1 2.55218480823434 2.96135446816238e-51 -0.259862115966063 0.00927399244683076 MirTarget;miRNATAP -0.168234298344575 1.8780051849382e-19 NA NA NA hsa-miR-200b-3p WIPF1 2.11744072703209 1.66710572104191e-43 -0.259862115966063 0.00927399244683076 MirTarget;TargetScan -0.191286536551454 2.66416174733952e-20 NA NA NA hsa-miR-200c-3p WIPF1 2.07038651806183 6.84613386286599e-51 -0.259862115966063 0.00927399244683076 MirTarget;miRNATAP -0.214983608550577 3.51466280882004e-21 NA NA NA hsa-miR-30a-5p WIPF1 -0.392489994825279 0.00954894667761676 -0.259862115966063 0.00927399244683076 MirTarget;miRNATAP -0.15690331044701 2.11443718308364e-12 NA NA NA hsa-miR-30b-5p WIPF1 -0.46540603860146 2.4709940429591e-05 -0.259862115966063 0.00927399244683076 MirTarget -0.183173061109685 2.57119735455151e-09 NA NA NA hsa-miR-30c-5p WIPF1 -0.393222674580066 8.06961465717306e-05 -0.259862115966063 0.00927399244683076 MirTarget;miRNATAP -0.244972204148147 5.12248040297844e-13 NA NA NA hsa-miR-30d-5p WIPF1 -0.247082219011045 0.00406717930063148 -0.259862115966063 0.00927399244683076 MirTarget;miRNATAP -0.235903545606817 2.85510095553717e-09 NA NA NA hsa-miR-338-3p WIPF1 0.0799903526884966 0.575137668326679 -0.259862115966063 0.00927399244683076 miRanda -0.155086708314558 7.1669430132896e-11 NA NA NA hsa-miR-429 WIPF1 2.84108892259147 3.88520896426515e-64 -0.259862115966063 0.00927399244683076 MirTarget;PITA;miRanda;miRNATAP -0.149155676053519 1.12977711919918e-15 NA NA NA hsa-miR-664a-3p WIPF1 -0.237699857923843 0.0197071390183375 -0.259862115966063 0.00927399244683076 MirTarget -0.192651343850069 8.59085702460848e-09 NA NA NA hsa-miR-664a-5p WIPF1 -0.292101258420761 0.00739803623640728 -0.259862115966063 0.00927399244683076 MirTarget -0.109997944496074 0.000490888985528819 NA NA NA hsa-miR-96-5p WIPF1 3.24596558166606 1.92296159041707e-98 -0.259862115966063 0.00927399244683076 miRNATAP -0.17727693941722 4.4720669610493e-20 NA NA NA hsa-let-7a-3p WNT5A 0.466622567891891 3.70886257943079e-07 -0.0987969676790623 0.559050375624812 miRNATAP -0.22117753231769 0.000441970481202632 NA NA NA hsa-miR-141-3p WNT5A 2.99777540204168 1.26370498493024e-78 -0.0987969676790623 0.559050375624812 TargetScan -0.139214845204003 2.12785375749739e-05 NA NA NA hsa-miR-144-5p WNT5A -2.75914786146772 1.55794225315972e-50 -0.0987969676790623 0.559050375624812 mirMAP -0.108189974261664 0.000232182868580216 NA NA NA hsa-miR-15b-3p WNT5A 1.12898579025388 1.18050912917317e-14 -0.0987969676790623 0.559050375624812 mirMAP -0.282465371884018 2.03011972026487e-13 NA NA NA hsa-miR-16-2-3p WNT5A 0.286355254959005 0.0256946046884474 -0.0987969676790623 0.559050375624812 MirTarget;mirMAP -0.339885804294178 3.30301649240528e-14 NA NA NA hsa-miR-16-5p WNT5A 0.46835991343556 1.91125356547776e-06 -0.0987969676790623 0.559050375624812 miRNAWalker2_validate -0.443371863255678 2.01154967356747e-14 NA NA NA hsa-miR-186-5p WNT5A -0.426987301460247 1.04129380549315e-05 -0.0987969676790623 0.559050375624812 miRNAWalker2_validate;mirMAP;miRNATAP -0.302944959464288 3.52342706593741e-07 NA NA NA hsa-miR-29a-5p WNT5A 0.334183773952055 0.00445137265870197 -0.0987969676790623 0.559050375624812 mirMAP -0.173390051712273 0.000449511750498096 NA NA NA hsa-miR-30b-5p WNT5A -0.46540603860146 2.4709940429591e-05 -0.0987969676790623 0.559050375624812 mirMAP -0.221268990849156 2.30222342732902e-05 NA NA NA hsa-miR-30c-5p WNT5A -0.393222674580066 8.06961465717306e-05 -0.0987969676790623 0.559050375624812 mirMAP -0.153444255475845 0.00829557687465555 NA NA NA hsa-miR-30d-3p WNT5A 0.264544633563642 0.00755023189129747 -0.0987969676790623 0.559050375624812 mirMAP -0.328486161205366 1.77036516167105e-08 NA NA NA hsa-miR-30d-5p WNT5A -0.247082219011045 0.00406717930063148 -0.0987969676790623 0.559050375624812 mirMAP -0.395918928140374 3.76530346593888e-09 NA NA NA hsa-miR-30e-5p WNT5A 0.293491764699475 0.000372291967271834 -0.0987969676790623 0.559050375624812 mirMAP -0.355937424695316 3.98104999357833e-07 NA NA NA hsa-miR-330-5p WNT5A 0.626063225953928 3.42215028606779e-09 -0.0987969676790623 0.559050375624812 miRanda -0.254694138871707 2.53849290717674e-06 NA NA NA hsa-miR-340-5p WNT5A 1.0857159627596 4.94471062546756e-24 -0.0987969676790623 0.559050375624812 miRNATAP -0.151352324882194 0.00401003633166406 NA NA NA hsa-miR-374b-5p WNT5A -0.466781429946153 1.17238311619116e-08 -0.0987969676790623 0.559050375624812 MirTarget;miRNATAP -0.20398183143879 0.00391173355873326 NA NA NA hsa-miR-576-5p WNT5A 0.0649387707567879 0.588791966096287 -0.0987969676790623 0.559050375624812 mirMAP -0.219900857430154 5.01514505641987e-06 NA NA NA hsa-miR-590-3p WNT5A 1.27438512890514 1.03164723481469e-23 -0.0987969676790623 0.559050375624812 miRanda;mirMAP;miRNATAP -0.276206250056969 2.00878373474974e-09 NA NA NA hsa-miR-7-1-3p WNT5A 0.686579567507582 1.20731554448806e-07 -0.0987969676790623 0.559050375624812 mirMAP -0.228321533184529 2.31205663077237e-07 NA NA NA hsa-miR-92a-3p WNT5A -0.342420481092807 0.000732275969501111 -0.0987969676790623 0.559050375624812 miRNAWalker2_validate -0.456191278985706 5.11502285589708e-16 NA NA NA