miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-125b-5p	AKT1	-1.94393269763542	2.78180543229264e-58	0.675644771423915	4.31393881321574e-23	miRNAWalker2_validate;miRTarBase	-0.198341990959858	1.58124486218174e-28		NA	NA	NA
hsa-miR-143-3p	AKT1	-1.23248181631499	4.74160976678504e-28	0.675644771423915	4.31393881321574e-23	miRNAWalker2_validate	-0.113351907486334	3.74647210660112e-08		NA	NA	NA
hsa-miR-24-3p	AKT2	-0.120123317289941	0.21432376743243	-0.0243409112523851	0.696831042278932	mirMAP	-0.108581040434418	8.76204903485834e-07		NA	NA	NA
hsa-miR-30e-3p	AKT2	-0.708952170420973	1.05866470714978e-22	-0.0243409112523851	0.696831042278932	mirMAP	-0.10769217628588	0.000202699653075448		NA	NA	NA
hsa-miR-106b-5p	AKT3	1.22477789913175	2.31787213143326e-32	-1.39153139819913	1.56022353185962e-23	miRNATAP	-0.328917679851073	3.2761525214021e-13		NA	NA	NA
hsa-miR-107	AKT3	0.678998026350662	2.56224148930538e-16	-1.39153139819913	1.56022353185962e-23	PITA;miRanda	-0.322045444014362	3.05085750718847e-08		NA	NA	NA
hsa-miR-15a-5p	AKT3	0.812445324157528	4.50263417099822e-20	-1.39153139819913	1.56022353185962e-23	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.50537113863267	1.94212195956378e-21		NA	NA	NA
hsa-miR-15b-5p	AKT3	0.788659356634696	1.13678211092534e-11	-1.39153139819913	1.56022353185962e-23	miRNATAP	-0.193152993862959	3.52162993117826e-06		NA	NA	NA
hsa-miR-16-5p	AKT3	0.46835991343556	1.91125356547776e-06	-1.39153139819913	1.56022353185962e-23	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.137142128931012	0.00593844300257035		NA	NA	NA
hsa-miR-181a-5p	AKT3	0.635863607630183	6.72486918157744e-11	-1.39153139819913	1.56022353185962e-23	miRNATAP	-0.151700435123375	0.00241569058552761		NA	NA	NA
hsa-miR-181b-5p	AKT3	1.22749257795094	1.21998198830919e-27	-1.39153139819913	1.56022353185962e-23	miRNATAP	-0.228362092376509	5.2632904676588e-08		NA	NA	NA
hsa-miR-20a-5p	AKT3	0.44979911120222	0.000602386964327228	-1.39153139819913	1.56022353185962e-23	miRNATAP	-0.142287905559561	0.000137185408492637		NA	NA	NA
hsa-miR-29b-2-5p	AKT3	-0.263499971180298	0.0400001755611965	-1.39153139819913	1.56022353185962e-23	mirMAP	-0.174192327083419	4.9828909918003e-06		NA	NA	NA
hsa-miR-29b-3p	AKT3	0.438847962603729	6.46722433236121e-05	-1.39153139819913	1.56022353185962e-23	miRNATAP	-0.240095261108435	6.25012390753699e-08	26512921	MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3		ovarian cancer
hsa-miR-29c-3p	AKT3	-0.0652732378039769	0.563774115756922	-1.39153139819913	1.56022353185962e-23	miRNAWalker2_validate;miRNATAP	-0.188130633733952	1.47230271027192e-05		NA	NA	NA
hsa-miR-340-5p	AKT3	1.0857159627596	4.94471062546756e-24	-1.39153139819913	1.56022353185962e-23	mirMAP	-0.283834227072162	1.26866636163553e-10		NA	NA	NA
hsa-miR-769-5p	AKT3	0.564871766265874	8.16695101656941e-10	-1.39153139819913	1.56022353185962e-23	PITA;miRNATAP	-0.188201328225218	0.000387633821142586		NA	NA	NA
hsa-miR-93-5p	AKT3	1.01788600209314	1.24312921618126e-21	-1.39153139819913	1.56022353185962e-23	miRNATAP	-0.358774978428685	5.45504344144073e-16		NA	NA	NA
hsa-miR-127-3p	BAD	-1.02337931491694	2.9749745518131e-15	0.671335929306102	6.05368129718844e-13	miRanda;miRNATAP	-0.12231920555334	5.77371456889348e-07		NA	NA	NA
hsa-miR-326	BAD	-1.54449030848141	1.04703417845594e-17	0.671335929306102	6.05368129718844e-13	miRanda	-0.162992963378128	2.73003852781454e-21		NA	NA	NA
hsa-miR-17-5p	CASP9	0.599531757298529	1.07318660415906e-05	0.0553003248250161	0.30285132191595	TargetScan	-0.101631873053047	1.40876150138688e-14		NA	NA	NA
hsa-miR-361-5p	CDC42	-0.0996867547900457	0.095428250126326	0.173789856138974	9.56157991686127e-05	miRanda	-0.123274419160974	1.83111084046675e-06		NA	NA	NA
hsa-let-7a-5p	HRAS	-0.210286642041636	0.0072546234707717	0.871315771945202	9.54693368299171e-15	miRNAWalker2_validate;miRTarBase	-0.156144832596741	0.00194814074250424	20607356;23134218;18344688;20033209;19323605	Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA	;;;;progression	glioblastoma;lung squamous cell cancer;lung cancer;lung cancer;pancreatic cancer
hsa-let-7b-5p	HRAS	-0.54215483448257	7.21347617597858e-08	0.871315771945202	9.54693368299171e-15	miRTarBase	-0.245640732103343	1.64072414700874e-10	20607356;20881268;18344688;20033209;19323605	Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA	;drug resistance;;;progression	glioblastoma;colorectal cancer;lung cancer;lung cancer;pancreatic cancer
hsa-miR-143-3p	HRAS	-1.23248181631499	4.74160976678504e-28	0.871315771945202	9.54693368299171e-15	miRNAWalker2_validate;miRTarBase	-0.13171025180707	9.59955008801748e-05	21276449	The Evi1 microRNA 143 K Ras axis in colon cancer		colon cancer
hsa-miR-766-3p	HRAS	0.496790679032227	8.22686414022553e-05	0.871315771945202	9.54693368299171e-15	MirTarget	-0.107283016649624	0.000532542374235056		NA	NA	NA
hsa-miR-330-5p	JMJD7-PLA2G4B	0.626063225953928	3.42215028606779e-09	-0.263856973511927	0.00391874846287315	miRNATAP	-0.231724089285207	1.24674326027351e-15		NA	NA	NA
hsa-miR-15a-5p	KDR	0.812445324157528	4.50263417099822e-20	-1.26178488366313	1.81783097872036e-35	miRNATAP	-0.352492195366687	4.38886869055548e-19		NA	NA	NA
hsa-miR-15b-5p	KDR	0.788659356634696	1.13678211092534e-11	-1.26178488366313	1.81783097872036e-35	miRNATAP	-0.158920943213795	2.46798947112166e-07		NA	NA	NA
hsa-miR-19b-1-5p	KDR	0.647704962003062	3.07687667945597e-07	-1.26178488366313	1.81783097872036e-35	miRNAWalker2_validate	-0.228393316601211	4.50410521305737e-16		NA	NA	NA
hsa-miR-200b-3p	KDR	2.11744072703209	1.66710572104191e-43	-1.26178488366313	1.81783097872036e-35	miRNAWalker2_validate;miRTarBase;TargetScan	-0.262999260406618	3.87053169124588e-34		NA	NA	NA
hsa-miR-200c-3p	KDR	2.07038651806183	6.84613386286599e-51	-1.26178488366313	1.81783097872036e-35	miRNATAP	-0.289279648433676	3.71227459751374e-34	24205206	MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c		lung squamous cell cancer
hsa-miR-3065-3p	KDR	1.62787885002468	6.81477830005026e-19	-1.26178488366313	1.81783097872036e-35	miRNATAP	-0.151833949842702	1.66297752718813e-15		NA	NA	NA
hsa-miR-429	KDR	2.84108892259147	3.88520896426515e-64	-1.26178488366313	1.81783097872036e-35	PITA;miRanda;miRNATAP	-0.244793933063007	3.13570384816226e-37		NA	NA	NA
hsa-miR-455-5p	KDR	0.284641224662773	0.0357572339594277	-1.26178488366313	1.81783097872036e-35	PITA;miRanda;miRNATAP	-0.184306159980816	3.7489040476857e-12		NA	NA	NA
hsa-miR-590-3p	KDR	1.27438512890514	1.03164723481469e-23	-1.26178488366313	1.81783097872036e-35	miRanda	-0.164817675844501	1.21955605160493e-08		NA	NA	NA
hsa-miR-590-5p	KDR	0.746515607868274	8.51300479640125e-09	-1.26178488366313	1.81783097872036e-35	miRanda	-0.121363305137282	1.22819221367569e-05		NA	NA	NA
hsa-miR-140-3p	KRAS	-1.25844395244141	5.29222651039892e-33	0.46818988509622	3.00748217900386e-10	MirTarget	-0.245149449217664	6.89860831179258e-27		NA	NA	NA
hsa-miR-143-3p	KRAS	-1.23248181631499	4.74160976678504e-28	0.46818988509622	3.00748217900386e-10	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.124135749972866	1.80319700574441e-08	22804917;27725862;19137007;26581910;23173124;26824186;21197560	In KRAS mutated tumours increased miR-200b and decreased miR-143 expression were associated with a good PFS;The expression of miR-143 is often down-regulated and it might play an important role by targeting KRAS in colorectal cancer CRC; Dual-luciferase reporter assays were performed to validate whether KRAS was regulated by miR-143; Dual-luciferase assays indicated that KRAS was a direct target of miR-143 as subsequently demonstrated by qPCR and western blot analysis showing that infection of SW480 cells with Ad-ZD55-miR-143 resulted in the down-regulation of KRAS at both mRNA and protein levels;Role of miR 143 targeting KRAS in colorectal tumorigenesis; In particular among a panel of presumed targets generated by in silico analysis that may interact with these aberrantly expressed miRNAs KRAS oncogene has been further experimentally validated as the target of miR-143; First an inverse correlation between KRAS protein and miR-143 in vivo was found; Second KRAS expression in Lovo cells was significantly abolished by treatment with miR-143 mimic whereas miR-143 inhibitor increased KRAS protein level; Third luciferase reporter assay confirmed that miR-143 directly recognize the 3'-untranslated region of KRAS transcripts; Finally inhibition of KRAS expression by miR-143 inhibits constitutive phosphorylation of ERK1/2; Taken together the present study provides the first evidences that miR-143 is significant in suppressing colorectal cancer cell growth through inhibition of KRAS translation;MicroRNA 143 replenishment re sensitizes colorectal cancer cells harboring mutant but not wild type KRAS to paclitaxel treatment; Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS; Combination of miR-143 mimic and paclitaxel induced the onset of apoptosis and reverted in vitro metastatic properties migration and invasion in KRAS mutant tumor cells; MiR-143 thus can be used as a chemosensitizer for the treatment of KRAS mutant tumors and warrants further investigations in in vitro and pre-clinical in vivo models;In turn the level of miR-143 in CRC cells decreasing the amount of MACC1 metastasis-associated in colon cancer-1 and oncogenic KRAS protein may be utilized as a prognostic marker;Stable miR-143 or miR-145 overexpression increased cell sensitivity to cetuximab resulting in a significant increase of cetuximab-mediated ADCC independently of KRAS status;miR 143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS; The expression level of miR-143 and its target gene KRAS were measured by realtime PCR and western blotting respectively; Our results revealed an inverse correlation of expression between miR-143 and KRAS protein in prostate cancer samples Pearson's correlation scatter plots: R = -0.707 P < 0.05; These findings suggest that miR-143 plays an important role in prostate cancer proliferation migration and chemosensitivity by suppressing KRAS and subsequent inactivation of MAPK pathway which provides a potential development of a new approach for the treatment of prostate cancer	;;tumorigenesis;;metastasis;;	colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colon cancer;prostate cancer
hsa-miR-195-3p	KRAS	-1.49582726452416	6.53261924105147e-40	0.46818988509622	3.00748217900386e-10	mirMAP	-0.144084535908296	1.9114583860958e-11		NA	NA	NA
hsa-miR-30d-5p	KRAS	-0.247082219011045	0.00406717930063148	0.46818988509622	3.00748217900386e-10	mirMAP;miRNATAP	-0.13177346252977	1.09256098608436e-05		NA	NA	NA
hsa-miR-542-3p	KRAS	0.568822103820889	8.5699075257651e-07	0.46818988509622	3.00748217900386e-10	miRanda	-0.123003016716369	2.33095765684339e-08		NA	NA	NA
hsa-miR-101-3p	MAP2K1	-0.126035286271986	0.145997832808138	-0.185433389862149	0.000727711407664528	miRNAWalker2_validate	-0.158307400181186	2.0108100169932e-13		NA	NA	NA
hsa-miR-181a-5p	MAP2K1	0.635863607630183	6.72486918157744e-11	-0.185433389862149	0.000727711407664528	miRNAWalker2_validate	-0.103686555340189	5.16890556712928e-08		NA	NA	NA
hsa-miR-361-5p	MAP2K1	-0.0996867547900457	0.095428250126326	-0.185433389862149	0.000727711407664528	miRanda	-0.121080950243885	0.000149537457617663		NA	NA	NA
hsa-miR-542-3p	MAP2K1	0.568822103820889	8.5699075257651e-07	-0.185433389862149	0.000727711407664528	miRanda	-0.113613468340007	1.26995828232255e-12		NA	NA	NA
hsa-let-7b-5p	MAP2K2	-0.54215483448257	7.21347617597858e-08	0.61941089334837	7.64917587016439e-15	miRNAWalker2_validate	-0.171851964586426	2.69292025446759e-10		NA	NA	NA
hsa-miR-29c-3p	MAPK1	-0.0652732378039769	0.563774115756922	-0.282469104608855	4.85723866828359e-06	mirMAP	-0.107930467813368	8.09848447187363e-09		NA	NA	NA
hsa-miR-361-5p	MAPK1	-0.0996867547900457	0.095428250126326	-0.282469104608855	4.85723866828359e-06	PITA;miRanda;mirMAP	-0.263780179525808	1.39108568009728e-13		NA	NA	NA
hsa-miR-3913-5p	MAPK1	0.71890413546147	2.61153227160465e-13	-0.282469104608855	4.85723866828359e-06	mirMAP	-0.145979254174869	5.54224263447113e-12		NA	NA	NA
hsa-miR-660-5p	MAPK1	0.406910761707485	0.000156175371762464	-0.282469104608855	4.85723866828359e-06	mirMAP	-0.144747929471906	1.05117786154161e-13		NA	NA	NA
hsa-miR-125a-5p	MAPK12	-0.635694700253268	3.6703235721638e-11	0.115659878295223	0.383319017822158	miRNATAP	-0.202093170321227	1.58081689346245e-05		NA	NA	NA
hsa-miR-335-5p	MAPK13	-2.61355235628987	2.6462884165886e-51	1.49058465220791	9.34310856898705e-63	mirMAP	-0.153169246178821	2.74313989203629e-18		NA	NA	NA
hsa-miR-21-5p	MAPK14	2.32007501846389	3.08394781855554e-137	-0.284160448012007	6.36269794096921e-09	mirMAP	-0.113666961486213	5.43544541750221e-14		NA	NA	NA
hsa-miR-361-5p	MAPK14	-0.0996867547900457	0.095428250126326	-0.284160448012007	6.36269794096921e-09	miRanda	-0.112257209621889	8.80745814280997e-05		NA	NA	NA
hsa-miR-197-3p	MAPK3	-0.526589453596294	3.61594599437195e-06	-0.0806112580526674	0.201094437565328	miRNATAP	-0.106370513582673	1.47526386613596e-08		NA	NA	NA
hsa-miR-125b-5p	MAPKAPK2	-1.94393269763542	2.78180543229264e-58	1.0251614728704	1.42861021749993e-41	MirTarget;mirMAP	-0.18586611487326	2.23783505848978e-19		NA	NA	NA
hsa-miR-495-3p	MAPKAPK2	-1.67685437612894	1.70634429769052e-34	1.0251614728704	1.42861021749993e-41	mirMAP	-0.142926123975903	4.80846007926985e-14		NA	NA	NA
hsa-miR-103a-3p	NFAT5	0.610673390034345	1.63113920514646e-12	-1.19902512228777	7.36927955059717e-50	MirTarget	-0.336653367297422	1.28063362403024e-24		NA	NA	NA
hsa-miR-106b-5p	NFAT5	1.22477789913175	2.31787213143326e-32	-1.19902512228777	7.36927955059717e-50	MirTarget;miRNATAP	-0.23715765114845	1.20613671461126e-18		NA	NA	NA
hsa-miR-107	NFAT5	0.678998026350662	2.56224148930538e-16	-1.19902512228777	7.36927955059717e-50	MirTarget	-0.295966190654869	8.65322066760854e-18		NA	NA	NA
hsa-miR-1301-3p	NFAT5	1.80754972811286	2.96809840886499e-36	-1.19902512228777	7.36927955059717e-50	MirTarget	-0.114089558751608	4.42769113606664e-09		NA	NA	NA
hsa-miR-141-3p	NFAT5	2.99777540204168	1.26370498493024e-78	-1.19902512228777	7.36927955059717e-50	mirMAP	-0.149337877858226	6.05474618072504e-20		NA	NA	NA
hsa-miR-148b-3p	NFAT5	1.0552576751879	1.6679285705231e-29	-1.19902512228777	7.36927955059717e-50	miRNATAP	-0.132221606001518	1.3758614517174e-05		NA	NA	NA
hsa-miR-155-5p	NFAT5	1.09766314984151	4.55650930885814e-15	-1.19902512228777	7.36927955059717e-50	mirMAP;miRNATAP	-0.100566120170304	1.0444676030806e-06		NA	NA	NA
hsa-miR-15a-5p	NFAT5	0.812445324157528	4.50263417099822e-20	-1.19902512228777	7.36927955059717e-50	MirTarget	-0.336948547662713	2.05581015414347e-26		NA	NA	NA
hsa-miR-16-1-3p	NFAT5	1.30142784811196	2.53343713753744e-29	-1.19902512228777	7.36927955059717e-50	mirMAP	-0.204713975377917	1.41977903192804e-15		NA	NA	NA
hsa-miR-17-3p	NFAT5	0.721439431208839	7.95900548819742e-10	-1.19902512228777	7.36927955059717e-50	mirMAP	-0.129870741981494	1.53941711137671e-07		NA	NA	NA
hsa-miR-181a-5p	NFAT5	0.635863607630183	6.72486918157744e-11	-1.19902512228777	7.36927955059717e-50	MirTarget;miRNATAP	-0.187828472037995	2.67099255156267e-10		NA	NA	NA
hsa-miR-181b-5p	NFAT5	1.22749257795094	1.21998198830919e-27	-1.19902512228777	7.36927955059717e-50	MirTarget;miRNATAP	-0.21216357383761	1.4174363007063e-17		NA	NA	NA
hsa-miR-194-5p	NFAT5	0.467781870340114	1.0386810618625e-07	-1.19902512228777	7.36927955059717e-50	miRNATAP	-0.127013805342984	0.000142318500250381		NA	NA	NA
hsa-miR-200a-3p	NFAT5	2.55218480823434	2.96135446816238e-51	-1.19902512228777	7.36927955059717e-50	mirMAP	-0.120533278835972	8.59748977733914e-14		NA	NA	NA
hsa-miR-21-3p	NFAT5	2.17476065946878	5.15299442583591e-75	-1.19902512228777	7.36927955059717e-50	MirTarget	-0.182888478641974	1.86723394339074e-16		NA	NA	NA
hsa-miR-21-5p	NFAT5	2.32007501846389	3.08394781855554e-137	-1.19902512228777	7.36927955059717e-50	miRNAWalker2_validate;mirMAP	-0.34259926440926	2.90805980799457e-41		NA	NA	NA
hsa-miR-32-5p	NFAT5	1.38676603945192	2.29428299685976e-34	-1.19902512228777	7.36927955059717e-50	miRNATAP	-0.186203151817271	3.61328449313256e-14		NA	NA	NA
hsa-miR-340-5p	NFAT5	1.0857159627596	4.94471062546756e-24	-1.19902512228777	7.36927955059717e-50	MirTarget	-0.253446045615689	2.48815325036697e-22		NA	NA	NA
hsa-miR-361-5p	NFAT5	-0.0996867547900457	0.095428250126326	-1.19902512228777	7.36927955059717e-50	MirTarget;PITA;mirMAP;miRNATAP	-0.133459394718286	0.00775411722566547		NA	NA	NA
hsa-miR-3613-5p	NFAT5	1.11067990676844	4.33424951743633e-21	-1.19902512228777	7.36927955059717e-50	miRNATAP	-0.103018827085653	2.39140009917872e-05		NA	NA	NA
hsa-miR-374a-3p	NFAT5	0.34122393953022	2.28714105382856e-05	-1.19902512228777	7.36927955059717e-50	mirMAP	-0.114187577439033	0.00184299941974274		NA	NA	NA
hsa-miR-429	NFAT5	2.84108892259147	3.88520896426515e-64	-1.19902512228777	7.36927955059717e-50	miRNATAP	-0.139784505249335	1.85265208110627e-18		NA	NA	NA
hsa-miR-590-3p	NFAT5	1.27438512890514	1.03164723481469e-23	-1.19902512228777	7.36927955059717e-50	MirTarget;miRanda;mirMAP;miRNATAP	-0.100697433581401	1.88485706745528e-05		NA	NA	NA
hsa-miR-92b-3p	NFAT5	1.30248132773644	9.42428674470985e-25	-1.19902512228777	7.36927955059717e-50	miRNATAP	-0.163288708475086	2.29328643304621e-13		NA	NA	NA
hsa-miR-93-5p	NFAT5	1.01788600209314	1.24312921618126e-21	-1.19902512228777	7.36927955059717e-50	MirTarget;miRNATAP	-0.248552951648198	4.68674105390296e-21		NA	NA	NA
hsa-miR-3127-5p	NFATC1	0.903405128081314	1.1325923598273e-12	-0.574736307447025	1.59178190713337e-08	MirTarget	-0.189661265640464	2.21630997061407e-12		NA	NA	NA
hsa-miR-182-5p	NFATC2	2.36408084103818	2.60011457600281e-72	-1.56755219359383	1.9388283538799e-13	mirMAP	-0.319993630027942	3.80744800734882e-10		NA	NA	NA
hsa-miR-185-5p	NFATC2	0.482334746589337	3.68475879959415e-09	-1.56755219359383	1.9388283538799e-13	MirTarget	-0.480154397877674	9.64194904728437e-08		NA	NA	NA
hsa-miR-19a-3p	NFATC2	0.817507952171848	3.76285090469625e-08	-1.56755219359383	1.9388283538799e-13	mirMAP	-0.325063324024532	3.38278468154619e-11		NA	NA	NA
hsa-miR-19b-3p	NFATC2	0.139124391010031	0.255658553872934	-1.56755219359383	1.9388283538799e-13	mirMAP	-0.287342497987003	2.05092326956767e-06		NA	NA	NA
hsa-miR-200b-5p	NFATC2	1.43091697052145	2.07975242866479e-22	-1.56755219359383	1.9388283538799e-13	mirMAP	-0.148120269747522	0.0033400668976821		NA	NA	NA
hsa-miR-320b	NFATC2	0.412787504747938	0.00113457276903985	-1.56755219359383	1.9388283538799e-13	MirTarget	-0.160231542240436	0.00642139736942507		NA	NA	NA
hsa-miR-340-5p	NFATC2	1.0857159627596	4.94471062546756e-24	-1.56755219359383	1.9388283538799e-13	miRNATAP	-0.377355443179726	1.70562760392822e-08		NA	NA	NA
hsa-miR-3613-5p	NFATC2	1.11067990676844	4.33424951743633e-21	-1.56755219359383	1.9388283538799e-13	mirMAP	-0.344189531636949	1.85303094879685e-08		NA	NA	NA
hsa-miR-423-5p	NFATC2	-0.0644843381453004	0.462275547464843	-1.56755219359383	1.9388283538799e-13	PITA	-0.329350686391576	0.000107038916546868		NA	NA	NA
hsa-miR-590-3p	NFATC2	1.27438512890514	1.03164723481469e-23	-1.56755219359383	1.9388283538799e-13	mirMAP	-0.207787840865524	0.000469613853353843		NA	NA	NA
hsa-miR-15a-5p	NFATC3	0.812445324157528	4.50263417099822e-20	-0.588395366455362	8.23189760727994e-21	MirTarget;miRNATAP	-0.231009103502432	3.55309483569134e-22		NA	NA	NA
hsa-miR-185-5p	NFATC3	0.482334746589337	3.68475879959415e-09	-0.588395366455362	8.23189760727994e-21	MirTarget;miRNATAP	-0.124879744848212	3.18788249333561e-06		NA	NA	NA
hsa-miR-29c-3p	NFATC3	-0.0652732378039769	0.563774115756922	-0.588395366455362	8.23189760727994e-21	MirTarget;miRNATAP	-0.133798476713389	4.59205597740966e-12		NA	NA	NA
hsa-miR-340-5p	NFATC3	1.0857159627596	4.94471062546756e-24	-0.588395366455362	8.23189760727994e-21	MirTarget	-0.153252771292197	7.73680776852044e-15		NA	NA	NA
hsa-miR-361-5p	NFATC3	-0.0996867547900457	0.095428250126326	-0.588395366455362	8.23189760727994e-21	miRanda	-0.178329966960041	1.80837796087919e-06		NA	NA	NA
hsa-miR-130b-5p	NFATC4	1.0573161199584	2.55177349228739e-12	0.464846681575293	0.00077326896248743	mirMAP	-0.273306003041798	2.37279973423709e-19		NA	NA	NA
hsa-miR-150-5p	NFATC4	-0.832049526091211	3.45299201139224e-05	0.464846681575293	0.00077326896248743	mirMAP	-0.127353989190525	5.08033729715864e-08		NA	NA	NA
hsa-miR-15b-3p	NFATC4	1.12898579025388	1.18050912917317e-14	0.464846681575293	0.00077326896248743	mirMAP	-0.238062507407611	4.12345167097552e-14		NA	NA	NA
hsa-miR-181a-2-3p	NFATC4	-0.0718643470098321	0.422077954889554	0.464846681575293	0.00077326896248743	mirMAP	-0.265900817473076	5.67846111588394e-07		NA	NA	NA
hsa-miR-185-3p	NFATC4	0.86591374114446	7.8790769678542e-10	0.464846681575293	0.00077326896248743	MirTarget	-0.221463917308086	4.38182247561287e-11		NA	NA	NA
hsa-miR-2355-5p	NFATC4	-0.221733044425126	0.0231054202524677	0.464846681575293	0.00077326896248743	MirTarget	-0.314673921460914	7.76236682155888e-11		NA	NA	NA
hsa-miR-29a-3p	NFATC4	-0.699539666833076	1.13935003139957e-13	0.464846681575293	0.00077326896248743	miRNATAP	-0.159424686343472	0.00138862402245239		NA	NA	NA
hsa-miR-29b-3p	NFATC4	0.438847962603729	6.46722433236121e-05	0.464846681575293	0.00077326896248743	miRNATAP	-0.122774285938033	0.00449585095871782		NA	NA	NA
hsa-miR-3607-3p	NFATC4	0.00697875745616461	0.972073275173643	0.464846681575293	0.00077326896248743	miRNATAP	-0.103148919948283	1.40847070939603e-05		NA	NA	NA
hsa-miR-361-3p	NFATC4	-0.0370446538644886	0.624902392829872	0.464846681575293	0.00077326896248743	mirMAP	-0.221299437804629	0.000469274259610322		NA	NA	NA
hsa-miR-484	NFATC4	0.349444060004737	0.00154491249625173	0.464846681575293	0.00077326896248743	MirTarget;miRNATAP	-0.195541918029345	5.21748391548856e-06		NA	NA	NA
hsa-miR-532-5p	NFATC4	0.0386976222860582	0.682018574136515	0.464846681575293	0.00077326896248743	mirMAP	-0.351153097111496	2.13922805026231e-12		NA	NA	NA
hsa-miR-629-3p	NFATC4	1.25035919247365	3.91361135469024e-14	0.464846681575293	0.00077326896248743	mirMAP	-0.222553384296637	1.10177313904365e-14		NA	NA	NA
hsa-miR-429	NOS3	2.84108892259147	3.88520896426515e-64	-0.415857403289588	4.78627333883668e-05	miRanda	-0.130650037890721	1.06798855882441e-11		NA	NA	NA
hsa-miR-26a-5p	NRAS	-0.481180084102235	1.82368246174758e-10	0.183758021967058	0.0269071454303856	mirMAP;miRNATAP	-0.171830491303475	4.57786379954293e-06	26458859	MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC		gastric cancer
hsa-miR-29a-3p	NRAS	-0.699539666833076	1.13935003139957e-13	0.183758021967058	0.0269071454303856	miRNATAP	-0.131093968344875	1.07589675767432e-05		NA	NA	NA
hsa-miR-29c-3p	NRAS	-0.0652732378039769	0.563774115756922	0.183758021967058	0.0269071454303856	miRNATAP	-0.211489064949879	1.38049039033829e-17		NA	NA	NA
hsa-miR-381-3p	NRAS	-1.28028930293369	1.61402949866141e-23	0.183758021967058	0.0269071454303856	mirMAP	-0.110038347690747	3.16999123322707e-07		NA	NA	NA
hsa-miR-146b-5p	PIK3CA	0.631041661167954	6.20366593452965e-08	-0.881957552231161	1.15529457057533e-22	mirMAP	-0.10172531442561	0.000163300940659646		NA	NA	NA
hsa-miR-148a-5p	PIK3CA	0.572692271754695	2.14306251522796e-06	-0.881957552231161	1.15529457057533e-22	mirMAP	-0.111623090383025	1.82115916734019e-05		NA	NA	NA
hsa-miR-200b-3p	PIK3CA	2.11744072703209	1.66710572104191e-43	-0.881957552231161	1.15529457057533e-22	TargetScan	-0.164394431071602	1.25931440199374e-17		NA	NA	NA
hsa-miR-361-5p	PIK3CA	-0.0996867547900457	0.095428250126326	-0.881957552231161	1.15529457057533e-22	mirMAP	-0.28523073173792	1.02307804662151e-07		NA	NA	NA
hsa-miR-96-5p	PIK3CA	3.24596558166606	1.92296159041707e-98	-0.881957552231161	1.15529457057533e-22	TargetScan	-0.158039482109614	1.06514304964241e-18		NA	NA	NA
hsa-miR-30b-3p	PIK3CD	-0.536462824497982	2.41814659272548e-05	-0.316904328019809	0.0048026997053421	MirTarget	-0.12656414985523	3.07110294580941e-05		NA	NA	NA
hsa-miR-484	PIK3CD	0.349444060004737	0.00154491249625173	-0.316904328019809	0.0048026997053421	MirTarget;miRNATAP	-0.141552727299567	4.96089022907138e-05		NA	NA	NA
hsa-miR-103a-3p	PIK3R1	0.610673390034345	1.63113920514646e-12	-1.70627489565512	1.28475917565256e-44	MirTarget;miRNATAP	-0.516011898515825	9.39970675304441e-26		NA	NA	NA
hsa-miR-106b-5p	PIK3R1	1.22477789913175	2.31787213143326e-32	-1.70627489565512	1.28475917565256e-44	MirTarget;miRNATAP	-0.458684807618424	6.41212047089543e-31		NA	NA	NA
hsa-miR-107	PIK3R1	0.678998026350662	2.56224148930538e-16	-1.70627489565512	1.28475917565256e-44	MirTarget;PITA;miRanda;miRNATAP	-0.564782368968385	1.29413413077175e-28		NA	NA	NA
hsa-miR-128-3p	PIK3R1	0.90296715955238	9.925204823863e-23	-1.70627489565512	1.28475917565256e-44	MirTarget	-0.464882086210543	2.18929508374026e-24	25962360	miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients	worse prognosis;progression	liver cancer
hsa-miR-1301-3p	PIK3R1	1.80754972811286	2.96809840886499e-36	-1.70627489565512	1.28475917565256e-44	MirTarget	-0.312737279865189	3.51588268231222e-28		NA	NA	NA
hsa-miR-15a-5p	PIK3R1	0.812445324157528	4.50263417099822e-20	-1.70627489565512	1.28475917565256e-44	MirTarget	-0.467053807879393	1.27196995879228e-22		NA	NA	NA
hsa-miR-15b-5p	PIK3R1	0.788659356634696	1.13678211092534e-11	-1.70627489565512	1.28475917565256e-44	MirTarget	-0.304923263873542	1.52536411684308e-16		NA	NA	NA
hsa-miR-16-2-3p	PIK3R1	0.286355254959005	0.0256946046884474	-1.70627489565512	1.28475917565256e-44	MirTarget	-0.187390623272605	5.18756959426033e-08		NA	NA	NA
hsa-miR-16-5p	PIK3R1	0.46835991343556	1.91125356547776e-06	-1.70627489565512	1.28475917565256e-44	MirTarget	-0.185144677288316	3.4393027748885e-05		NA	NA	NA
hsa-miR-17-5p	PIK3R1	0.599531757298529	1.07318660415906e-05	-1.70627489565512	1.28475917565256e-44	MirTarget;TargetScan;miRNATAP	-0.305623214527227	2.73465966965389e-22		NA	NA	NA
hsa-miR-182-5p	PIK3R1	2.36408084103818	2.60011457600281e-72	-1.70627489565512	1.28475917565256e-44	miRNATAP	-0.209986504782115	4.31661758321545e-12		NA	NA	NA
hsa-miR-185-5p	PIK3R1	0.482334746589337	3.68475879959415e-09	-1.70627489565512	1.28475917565256e-44	miRNATAP	-0.576307293918371	1.92791131730155e-28		NA	NA	NA
hsa-miR-200b-3p	PIK3R1	2.11744072703209	1.66710572104191e-43	-1.70627489565512	1.28475917565256e-44	mirMAP	-0.193888157381114	6.36921236487692e-13		NA	NA	NA
hsa-miR-200c-3p	PIK3R1	2.07038651806183	6.84613386286599e-51	-1.70627489565512	1.28475917565256e-44	mirMAP	-0.257145031020416	2.3912254219973e-18		NA	NA	NA
hsa-miR-20a-5p	PIK3R1	0.44979911120222	0.000602386964327228	-1.70627489565512	1.28475917565256e-44	MirTarget;miRNATAP	-0.329404805146422	7.47770247059783e-24		NA	NA	NA
hsa-miR-21-5p	PIK3R1	2.32007501846389	3.08394781855554e-137	-1.70627489565512	1.28475917565256e-44	miRNAWalker2_validate;MirTarget;miRNATAP	-0.442813578327247	2.68375696066295e-30	26676464	PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer	cell migration	breast cancer
hsa-miR-29b-3p	PIK3R1	0.438847962603729	6.46722433236121e-05	-1.70627489565512	1.28475917565256e-44	MirTarget;miRNATAP	-0.212535407562809	1.00431864575306e-07		NA	NA	NA
hsa-miR-320b	PIK3R1	0.412787504747938	0.00113457276903985	-1.70627489565512	1.28475917565256e-44	miRNATAP	-0.140552558146201	5.57745902628767e-05		NA	NA	NA
hsa-miR-324-3p	PIK3R1	0.404877731996915	0.000340036423920834	-1.70627489565512	1.28475917565256e-44	MirTarget;PITA;miRNATAP	-0.224592588456891	6.81384539720142e-09		NA	NA	NA
hsa-miR-330-3p	PIK3R1	0.432728362037032	0.00041335506960812	-1.70627489565512	1.28475917565256e-44	MirTarget;PITA;miRNATAP	-0.144041669892523	7.57903802651215e-05		NA	NA	NA
hsa-miR-361-5p	PIK3R1	-0.0996867547900457	0.095428250126326	-1.70627489565512	1.28475917565256e-44	MirTarget;PITA;miRanda;mirMAP;miRNATAP	-0.278078422988115	0.000207710985727821		NA	NA	NA
hsa-miR-429	PIK3R1	2.84108892259147	3.88520896426515e-64	-1.70627489565512	1.28475917565256e-44	mirMAP;miRNATAP	-0.22503499935046	3.34180951947627e-21		NA	NA	NA
hsa-miR-590-3p	PIK3R1	1.27438512890514	1.03164723481469e-23	-1.70627489565512	1.28475917565256e-44	miRanda;mirMAP	-0.239713681587516	7.2007499793076e-12		NA	NA	NA
hsa-miR-590-5p	PIK3R1	0.746515607868274	8.51300479640125e-09	-1.70627489565512	1.28475917565256e-44	MirTarget;PITA;miRanda;miRNATAP	-0.209937562895491	3.68537681569131e-10		NA	NA	NA
hsa-miR-629-3p	PIK3R1	1.25035919247365	3.91361135469024e-14	-1.70627489565512	1.28475917565256e-44	MirTarget	-0.122961236064884	5.54567297669118e-06		NA	NA	NA
hsa-miR-93-5p	PIK3R1	1.01788600209314	1.24312921618126e-21	-1.70627489565512	1.28475917565256e-44	MirTarget;miRNATAP	-0.499295395694502	3.97678732290002e-38		NA	NA	NA
hsa-miR-96-5p	PIK3R1	3.24596558166606	1.92296159041707e-98	-1.70627489565512	1.28475917565256e-44	TargetScan;miRNATAP	-0.245653154038236	3.77424010710224e-23		NA	NA	NA
hsa-miR-126-3p	PIK3R2	-1.17432628002954	1.02041618253013e-20	1.28293433832686	8.5972816204378e-73	miRNAWalker2_validate;miRTarBase	-0.169496363080053	8.52458360518473e-17	21249429;26384552;27578985;26191164;25240815	Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC;MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2	;poor survival;;progression;metastasis	breast cancer;thyroid cancer;bladder cancer;esophageal cancer;liver cancer
hsa-miR-28-5p	PIK3R2	-0.14267073663385	0.0497619246260571	1.28293433832686	8.5972816204378e-73	miRanda	-0.170225138245223	4.06181677270291e-06		NA	NA	NA
hsa-miR-30b-5p	PIK3R2	-0.46540603860146	2.4709940429591e-05	1.28293433832686	8.5972816204378e-73	miRNATAP	-0.111541133552651	3.5447180691879e-06		NA	NA	NA
hsa-miR-30c-5p	PIK3R2	-0.393222674580066	8.06961465717306e-05	1.28293433832686	8.5972816204378e-73	miRNAWalker2_validate;miRNATAP	-0.102854891876324	0.000118472431445014		NA	NA	NA
hsa-miR-30d-5p	PIK3R2	-0.247082219011045	0.00406717930063148	1.28293433832686	8.5972816204378e-73	miRNATAP	-0.135541098242265	1.30568664423737e-05		NA	NA	NA
hsa-miR-320a	PIK3R2	-0.287921276129346	0.00141693637596294	1.28293433832686	8.5972816204378e-73	miRanda	-0.151022063052727	3.16338469232646e-07		NA	NA	NA
hsa-miR-491-5p	PIK3R2	-1.04307210952796	1.14586501470398e-15	1.28293433832686	8.5972816204378e-73	miRanda	-0.116485616092769	7.44579853361516e-09		NA	NA	NA
hsa-miR-181a-5p	PIK3R3	0.635863607630183	6.72486918157744e-11	0.559172960265555	3.98014986716526e-09	MirTarget;miRNATAP	-0.146056981056209	1.20649375988888e-05		NA	NA	NA
hsa-miR-19b-3p	PIK3R3	0.139124391010031	0.255658553872934	0.559172960265555	3.98014986716526e-09	MirTarget;miRNATAP	-0.109224067759979	4.71454242795867e-05		NA	NA	NA
hsa-miR-217	PIK3R3	-0.616728851115349	8.64977119332241e-05	0.559172960265555	3.98014986716526e-09	PITA;miRanda	-0.118432783728797	1.05730160913028e-08		NA	NA	NA
hsa-miR-25-3p	PIK3R3	-0.00546790775985073	0.944061771389468	0.559172960265555	3.98014986716526e-09	MirTarget	-0.129911102729152	0.00226643466666436		NA	NA	NA
hsa-miR-26a-5p	PIK3R3	-0.481180084102235	1.82368246174758e-10	0.559172960265555	3.98014986716526e-09	miRNATAP	-0.28216506702381	5.37056936747542e-11		NA	NA	NA
hsa-miR-374a-5p	PIK3R3	-0.239709888246804	0.00309819667153627	0.559172960265555	3.98014986716526e-09	mirMAP	-0.121442827230575	0.0029020400924295		NA	NA	NA
hsa-miR-374b-5p	PIK3R3	-0.466781429946153	1.17238311619116e-08	0.559172960265555	3.98014986716526e-09	mirMAP	-0.120196538768652	0.00271578207935794		NA	NA	NA
hsa-miR-381-3p	PIK3R3	-1.28028930293369	1.61402949866141e-23	0.559172960265555	3.98014986716526e-09	mirMAP	-0.140767078074606	1.38941193259491e-08		NA	NA	NA
hsa-miR-532-5p	PIK3R3	0.0386976222860582	0.682018574136515	0.559172960265555	3.98014986716526e-09	mirMAP	-0.140279487612118	5.85354025061255e-05		NA	NA	NA
hsa-miR-92a-3p	PIK3R3	-0.342420481092807	0.000732275969501111	0.559172960265555	3.98014986716526e-09	MirTarget;miRNATAP	-0.227757876133252	1.19233380886192e-12		NA	NA	NA
hsa-miR-125a-5p	PIK3R5	-0.635694700253268	3.6703235721638e-11	0.311128035887536	0.0038375952038782	MirTarget;miRanda	-0.280593880513026	8.91996620676494e-14		NA	NA	NA
hsa-miR-182-5p	PIK3R5	2.36408084103818	2.60011457600281e-72	0.311128035887536	0.0038375952038782	MirTarget	-0.108305079676846	2.32094065834864e-05		NA	NA	NA
hsa-miR-335-5p	PLA2G10	-2.61355235628987	2.6462884165886e-51	2.58043646182214	4.92737062096255e-20	miRNAWalker2_validate	-0.240771211021386	6.4577488535009e-06		NA	NA	NA
hsa-miR-106b-5p	PLA2G12A	1.22477789913175	2.31787213143326e-32	-0.0767339324942657	0.320227624149064	mirMAP	-0.183165390972991	4.54130357375406e-14		NA	NA	NA
hsa-miR-140-5p	PLA2G12A	-0.755971041589807	9.68060922934542e-14	-0.0767339324942657	0.320227624149064	miRanda	-0.111542024637763	1.35365987147148e-05		NA	NA	NA
hsa-miR-142-5p	PLA2G12A	1.16509303143593	1.96641162209073e-13	-0.0767339324942657	0.320227624149064	mirMAP	-0.164913109247326	4.6875674436803e-25		NA	NA	NA
hsa-miR-150-5p	PLA2G12A	-0.832049526091211	3.45299201139224e-05	-0.0767339324942657	0.320227624149064	mirMAP	-0.111662148908207	3.06157352459707e-18		NA	NA	NA
hsa-miR-17-3p	PLA2G12A	0.721439431208839	7.95900548819742e-10	-0.0767339324942657	0.320227624149064	mirMAP	-0.253144933851736	4.89224736100484e-32		NA	NA	NA
hsa-miR-17-5p	PLA2G12A	0.599531757298529	1.07318660415906e-05	-0.0767339324942657	0.320227624149064	mirMAP	-0.127012977325803	3.04058434715778e-11		NA	NA	NA
hsa-miR-181a-5p	PLA2G12A	0.635863607630183	6.72486918157744e-11	-0.0767339324942657	0.320227624149064	mirMAP	-0.134430081680054	5.19065518814422e-07		NA	NA	NA
hsa-miR-181b-5p	PLA2G12A	1.22749257795094	1.21998198830919e-27	-0.0767339324942657	0.320227624149064	mirMAP	-0.120036146387448	1.07543463907263e-07		NA	NA	NA
hsa-miR-181c-5p	PLA2G12A	0.574847839298605	4.51287502066478e-07	-0.0767339324942657	0.320227624149064	mirMAP	-0.100247651965663	1.33006792327325e-05		NA	NA	NA
hsa-miR-20a-5p	PLA2G12A	0.44979911120222	0.000602386964327228	-0.0767339324942657	0.320227624149064	mirMAP	-0.175197436263123	6.04261955331153e-19		NA	NA	NA
hsa-miR-340-5p	PLA2G12A	1.0857159627596	4.94471062546756e-24	-0.0767339324942657	0.320227624149064	mirMAP	-0.150943983546617	2.10910414124104e-10		NA	NA	NA
hsa-miR-374a-3p	PLA2G12A	0.34122393953022	2.28714105382856e-05	-0.0767339324942657	0.320227624149064	mirMAP	-0.186349201857001	1.16022667976458e-08		NA	NA	NA
hsa-miR-590-3p	PLA2G12A	1.27438512890514	1.03164723481469e-23	-0.0767339324942657	0.320227624149064	PITA;miRanda;miRNATAP	-0.102840132884099	1.06330234376856e-06		NA	NA	NA
hsa-miR-93-5p	PLA2G12A	1.01788600209314	1.24312921618126e-21	-0.0767339324942657	0.320227624149064	mirMAP	-0.16549588295931	4.93444853641411e-12		NA	NA	NA
hsa-miR-338-3p	PLA2G2D	0.0799903526884966	0.575137668326679	0.903280745620558	0.00272639495429831	mirMAP	-0.305823183035727	2.42881736158958e-05		NA	NA	NA
hsa-miR-491-5p	PLA2G2D	-1.04307210952796	1.14586501470398e-15	0.903280745620558	0.00272639495429831	miRanda	-0.303164177428281	0.000114708849288704		NA	NA	NA
hsa-let-7d-5p	PLA2G3	0.410958462607207	6.07808182756787e-06	-0.0228531479929619	0.949949867171402	MirTarget	-0.390954081984527	0.00443149825913952		NA	NA	NA
hsa-miR-98-5p	PLA2G3	0.656336869298973	9.03113188590466e-15	-0.0228531479929619	0.949949867171402	MirTarget	-0.648796955398098	8.08248391006914e-06		NA	NA	NA
hsa-miR-1301-3p	PLA2G4A	1.80754972811286	2.96809840886499e-36	-2.53505849018895	2.47040724186526e-47	MirTarget	-0.203345804091857	1.5174493413245e-06		NA	NA	NA
hsa-miR-181b-5p	PLA2G4A	1.22749257795094	1.21998198830919e-27	-2.53505849018895	2.47040724186526e-47	MirTarget	-0.153639845367177	0.00515313352093704		NA	NA	NA
hsa-miR-181c-5p	PLA2G4A	0.574847839298605	4.51287502066478e-07	-2.53505849018895	2.47040724186526e-47	MirTarget	-0.154311584569564	0.00569702831812597		NA	NA	NA
hsa-miR-128-3p	PLA2G5	0.90296715955238	9.925204823863e-23	-1.74013770344495	1.68659762319176e-24	miRNAWalker2_validate	-0.343165736360574	6.67242916325325e-08		NA	NA	NA
hsa-miR-330-5p	PLA2G5	0.626063225953928	3.42215028606779e-09	-1.74013770344495	1.68659762319176e-24	miRanda	-0.327612442041135	4.95284334111594e-09		NA	NA	NA
hsa-miR-429	PLA2G5	2.84108892259147	3.88520896426515e-64	-1.74013770344495	1.68659762319176e-24	miRanda	-0.333900447814793	4.56777352167666e-25		NA	NA	NA
hsa-miR-590-3p	PLA2G5	1.27438512890514	1.03164723481469e-23	-1.74013770344495	1.68659762319176e-24	miRanda;miRNATAP	-0.259835376156245	5.88331349780208e-08		NA	NA	NA
hsa-miR-590-5p	PLA2G5	0.746515607868274	8.51300479640125e-09	-1.74013770344495	1.68659762319176e-24	miRanda	-0.191992596578893	2.94285112416766e-05		NA	NA	NA
hsa-let-7f-5p	PPP3CA	0.12216148416417	0.221351291433294	-0.544246415257643	5.77237427579346e-09	miRNATAP	-0.102194254433793	0.00165189815382032		NA	NA	NA
hsa-miR-106b-5p	PPP3CA	1.22477789913175	2.31787213143326e-32	-0.544246415257643	5.77237427579346e-09	miRNATAP	-0.163746270795427	4.48730421523751e-08		NA	NA	NA
hsa-miR-17-3p	PPP3CA	0.721439431208839	7.95900548819742e-10	-0.544246415257643	5.77237427579346e-09	MirTarget	-0.124078923715287	5.08318296663462e-06		NA	NA	NA
hsa-miR-194-5p	PPP3CA	0.467781870340114	1.0386810618625e-07	-0.544246415257643	5.77237427579346e-09	MirTarget	-0.132376274530416	0.000303144003211118		NA	NA	NA
hsa-miR-20a-5p	PPP3CA	0.44979911120222	0.000602386964327228	-0.544246415257643	5.77237427579346e-09	miRNATAP	-0.110326267376209	6.81988772591416e-06		NA	NA	NA
hsa-miR-21-5p	PPP3CA	2.32007501846389	3.08394781855554e-137	-0.544246415257643	5.77237427579346e-09	miRNATAP	-0.171857455775929	3.70280677648987e-09		NA	NA	NA
hsa-miR-340-5p	PPP3CA	1.0857159627596	4.94471062546756e-24	-0.544246415257643	5.77237427579346e-09	mirMAP	-0.176067551771713	1.43168876315375e-09		NA	NA	NA
hsa-miR-361-5p	PPP3CA	-0.0996867547900457	0.095428250126326	-0.544246415257643	5.77237427579346e-09	miRanda	-0.244052441662145	8.38230854446672e-06		NA	NA	NA
hsa-miR-93-5p	PPP3CA	1.01788600209314	1.24312921618126e-21	-0.544246415257643	5.77237427579346e-09	miRNATAP	-0.162948227314112	3.15959129159339e-08		NA	NA	NA
hsa-miR-107	PPP3CB	0.678998026350662	2.56224148930538e-16	-0.507852474824067	3.82558012937129e-19	miRanda	-0.128823034238509	4.39638835494672e-08		NA	NA	NA
hsa-miR-146b-5p	PPP3CB	0.631041661167954	6.20366593452965e-08	-0.507852474824067	3.82558012937129e-19	miRanda	-0.171198371090796	2.36585494803099e-25		NA	NA	NA
hsa-miR-15a-5p	PPP3CB	0.812445324157528	4.50263417099822e-20	-0.507852474824067	3.82558012937129e-19	miRNATAP	-0.126089090631579	8.14069089424982e-09		NA	NA	NA
hsa-miR-340-5p	PPP3CB	1.0857159627596	4.94471062546756e-24	-0.507852474824067	3.82558012937129e-19	MirTarget	-0.156446625862705	8.32036945224755e-19		NA	NA	NA
hsa-miR-361-5p	PPP3CB	-0.0996867547900457	0.095428250126326	-0.507852474824067	3.82558012937129e-19	miRanda	-0.218861370922051	6.00579314883281e-11		NA	NA	NA
hsa-miR-101-3p	PPP3R1	-0.126035286271986	0.145997832808138	-0.297052041419911	9.95522907099635e-08	miRNATAP	-0.187171459954337	1.17776284425277e-17		NA	NA	NA
hsa-miR-181c-5p	PPP3R1	0.574847839298605	4.51287502066478e-07	-0.297052041419911	9.95522907099635e-08	MirTarget;miRNATAP	-0.125950184238424	2.66954355100233e-14		NA	NA	NA
hsa-miR-26a-5p	PPP3R1	-0.481180084102235	1.82368246174758e-10	-0.297052041419911	9.95522907099635e-08	MirTarget;miRNATAP	-0.15120972679612	1.94023722332139e-09		NA	NA	NA
hsa-miR-30a-5p	PPP3R1	-0.392489994825279	0.00954894667761676	-0.297052041419911	9.95522907099635e-08	miRNAWalker2_validate;MirTarget;miRNATAP	-0.13382780475557	1.01801426792285e-27		NA	NA	NA
hsa-miR-181b-5p	PRKCA	1.22749257795094	1.21998198830919e-27	-1.70723657875247	1.7688165305473e-34	mirMAP	-0.11742885805708	0.0062191009662321		NA	NA	NA
hsa-miR-181c-5p	PRKCA	0.574847839298605	4.51287502066478e-07	-1.70723657875247	1.7688165305473e-34	mirMAP	-0.151937361609795	0.00048559417186175		NA	NA	NA
hsa-miR-183-5p	PRKCA	2.95681814393872	1.09965777344285e-92	-1.70723657875247	1.7688165305473e-34	miRNATAP	-0.382401275003301	4.39521361355191e-39		NA	NA	NA
hsa-miR-193b-3p	PRKCA	-0.0550374855074773	0.65382485898551	-1.70723657875247	1.7688165305473e-34	miRNAWalker2_validate	-0.158591304154604	9.61914010087921e-05		NA	NA	NA
hsa-miR-194-5p	PRKCA	0.467781870340114	1.0386810618625e-07	-1.70723657875247	1.7688165305473e-34	mirMAP	-0.194734764385864	0.000579018161354159		NA	NA	NA
hsa-miR-200b-3p	PRKCA	2.11744072703209	1.66710572104191e-43	-1.70723657875247	1.7688165305473e-34	TargetScan	-0.338107140907763	7.43601898887161e-30		NA	NA	NA
hsa-miR-200c-3p	PRKCA	2.07038651806183	6.84613386286599e-51	-1.70723657875247	1.7688165305473e-34	miRNATAP	-0.384868851727468	4.79014422420278e-32		NA	NA	NA
hsa-miR-29b-2-5p	PRKCA	-0.263499971180298	0.0400001755611965	-1.70723657875247	1.7688165305473e-34	mirMAP	-0.365220324605892	6.60788568306249e-22		NA	NA	NA
hsa-miR-30d-3p	PRKCA	0.264544633563642	0.00755023189129747	-1.70723657875247	1.7688165305473e-34	mirMAP	-0.185045137833304	0.000246654172160224		NA	NA	NA
hsa-miR-339-5p	PRKCA	-0.211548290465418	0.0685885445822389	-1.70723657875247	1.7688165305473e-34	mirMAP	-0.116903398908303	0.00661066095178211		NA	NA	NA
hsa-miR-340-5p	PRKCA	1.0857159627596	4.94471062546756e-24	-1.70723657875247	1.7688165305473e-34	mirMAP	-0.157880969288124	0.000482930053726641		NA	NA	NA
hsa-miR-375	PRKCA	2.09893673049766	1.68351780396203e-16	-1.70723657875247	1.7688165305473e-34	miRNAWalker2_validate	-0.240131861837491	2.29799527522168e-39		NA	NA	NA
hsa-miR-429	PRKCA	2.84108892259147	3.88520896426515e-64	-1.70723657875247	1.7688165305473e-34	miRanda;miRNATAP	-0.302006017947741	7.14515269636082e-30		NA	NA	NA
hsa-miR-141-5p	PRKCB	2.38411349683216	4.56310582620282e-58	-0.447147877250759	0.0168049140120418	mirMAP	-0.127187131565152	0.00154757873879663		NA	NA	NA
hsa-miR-200b-3p	PRKCB	2.11744072703209	1.66710572104191e-43	-0.447147877250759	0.0168049140120418	MirTarget	-0.185811618752792	2.61023291805883e-06		NA	NA	NA
hsa-miR-200c-3p	PRKCB	2.07038651806183	6.84613386286599e-51	-0.447147877250759	0.0168049140120418	MirTarget;miRNATAP	-0.190171510726694	1.24294313881003e-05		NA	NA	NA
hsa-miR-29b-2-5p	PRKCB	-0.263499971180298	0.0400001755611965	-0.447147877250759	0.0168049140120418	mirMAP	-0.248738713275143	5.96583916655133e-07		NA	NA	NA
hsa-miR-30b-5p	PRKCB	-0.46540603860146	2.4709940429591e-05	-0.447147877250759	0.0168049140120418	mirMAP	-0.181899501701348	0.00172429854651836		NA	NA	NA
hsa-miR-30c-5p	PRKCB	-0.393222674580066	8.06961465717306e-05	-0.447147877250759	0.0168049140120418	mirMAP	-0.266676621567604	3.26692465594906e-05		NA	NA	NA
hsa-miR-30d-3p	PRKCB	0.264544633563642	0.00755023189129747	-0.447147877250759	0.0168049140120418	mirMAP	-0.176195796338334	0.00676988213351706		NA	NA	NA
hsa-miR-338-3p	PRKCB	0.0799903526884966	0.575137668326679	-0.447147877250759	0.0168049140120418	miRanda	-0.216031823790678	1.44429456470486e-06		NA	NA	NA
hsa-miR-429	PRKCB	2.84108892259147	3.88520896426515e-64	-0.447147877250759	0.0168049140120418	MirTarget;miRanda;miRNATAP	-0.177108211107202	5.14864677602474e-07		NA	NA	NA
hsa-miR-664a-3p	PRKCB	-0.237699857923843	0.0197071390183375	-0.447147877250759	0.0168049140120418	mirMAP	-0.30918523276408	8.70938453871888e-07		NA	NA	NA
hsa-let-7a-3p	PTGS2	0.466622567891891	3.70886257943079e-07	-3.06633598017193	1.49322904633926e-36	mirMAP	-0.337477755412216	0.000364798399722517		NA	NA	NA
hsa-miR-128-3p	PTGS2	0.90296715955238	9.925204823863e-23	-3.06633598017193	1.49322904633926e-36	miRNAWalker2_validate	-0.419594716339365	5.45785222232396e-06		NA	NA	NA
hsa-miR-16-5p	PTGS2	0.46835991343556	1.91125356547776e-06	-3.06633598017193	1.49322904633926e-36	miRNAWalker2_validate;miRTarBase	-0.310458714358359	0.00044330945828749	24759835;25196524	MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels;Artesunate induces apoptosis of bladder cancer cells by miR 16 regulation of COX 2 expression; Cyclooxygenase-2 COX-2 and miR-16 expression levels were determined with real-time PCR; ART efficiently inhibited orthotopic tumor growth in the bladder cancer rat which is accompanied with an increase of miR-16 expression and a decrease of COX-2 expression; ART significantly increased miR-16 expression and decreased the expression of COX-2 and the production of PGE2; More importantly down-regulation of miR-16 expression could reverse the effect of ART on apoptosis and COX-2 expression in bladder cells; In conclusion ART can elicit an anti-tumor effect against bladder cancer by up-regulation of miR-16 expression which resulted in the decrease of COX-2 expression and PGE2 production	;	liver cancer;bladder cancer
hsa-miR-181a-5p	PTGS2	0.635863607630183	6.72486918157744e-11	-3.06633598017193	1.49322904633926e-36	miRNAWalker2_validate	-0.259582591672132	0.00346310822015656		NA	NA	NA
hsa-miR-429	PTGS2	2.84108892259147	3.88520896426515e-64	-3.06633598017193	1.49322904633926e-36	miRanda;miRNATAP	-0.404133193488026	1.1658704706728e-17		NA	NA	NA
hsa-miR-7-1-3p	PTGS2	0.686579567507582	1.20731554448806e-07	-3.06633598017193	1.49322904633926e-36	MirTarget	-0.408411656292787	6.78920408572214e-10		NA	NA	NA
hsa-let-7c-5p	PTK2	-1.9415540533505	9.55250745007793e-48	0.34551403513174	7.59893035573032e-07	miRNAWalker2_validate	-0.145523582147357	2.05630494198177e-18		NA	NA	NA
hsa-miR-139-5p	PTK2	-3.25846663863766	2.62018989415003e-112	0.34551403513174	7.59893035573032e-07	miRanda	-0.109205234931847	1.69268288863156e-14		NA	NA	NA
hsa-miR-199a-5p	PTK2	-0.314703593105081	0.00909304983051124	0.34551403513174	7.59893035573032e-07	miRanda	-0.117208700092394	3.25513954280803e-09		NA	NA	NA
hsa-miR-199b-5p	PTK2	-1.37022396448377	3.25758057539223e-26	0.34551403513174	7.59893035573032e-07	miRanda	-0.147263766750288	9.5558677434372e-17		NA	NA	NA
hsa-miR-379-5p	PTK2	-1.29872802686271	5.33844249801446e-22	0.34551403513174	7.59893035573032e-07	MirTarget	-0.128620655965672	6.92581265300639e-14	26944318	Moreover miR-379-5p exerted this function by directly targeting focal adhesion kinase FAK 3'-UTR and repressing FAK expression thus leading to suppression of AKT signaling; Furthermore the tumor suppressive effects of miR-379-5p in HCC cells were reversed by activating AKT signaling or restoring FAK expression; In clinical samples of HCC miR-379-5p negatively correlated with FAK which was up-regulated in HCC		liver cancer
hsa-miR-92a-3p	PXN	-0.342420481092807	0.000732275969501111	-0.431317792115143	2.28707775521156e-12	miRNAWalker2_validate	-0.12544049433046	1.88780385971249e-09		NA	NA	NA
hsa-miR-101-3p	RAC1	-0.126035286271986	0.145997832808138	0.176628662773421	0.000153658997491136	miRNAWalker2_validate;MirTarget	-0.139972978942608	1.93650351223228e-14	25202416;24649082;25057058	In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR	cell migration;;	thyroid cancer;thyroid cancer;colorectal cancer
hsa-miR-193b-3p	RAC2	-0.0550374855074773	0.65382485898551	0.739175691283857	1.48014827234175e-09	miRNAWalker2_validate	-0.163439972898065	2.05534635731132e-06		NA	NA	NA
hsa-miR-491-5p	RAC2	-1.04307210952796	1.14586501470398e-15	0.739175691283857	1.48014827234175e-09	miRanda	-0.170510866222564	9.84222871672058e-08		NA	NA	NA
hsa-miR-125a-5p	RAC3	-0.635694700253268	3.6703235721638e-11	1.34875128530309	1.88353993751843e-24	PITA	-0.214154670070607	8.31103753734932e-06		NA	NA	NA
hsa-miR-195-5p	SH2D2A	-1.47508108420708	2.20685847368258e-38	1.40365434187352	6.08296701454048e-15	MirTarget	-0.161140054572113	0.00220271801926292		NA	NA	NA
hsa-miR-497-5p	SH2D2A	-1.4667331575679	5.49909921822638e-36	1.40365434187352	6.08296701454048e-15	MirTarget	-0.213388319757551	3.07844058713593e-05		NA	NA	NA
hsa-miR-186-5p	SHC2	-0.426987301460247	1.04129380549315e-05	-0.181909094931012	0.296045257869179	miRNAWalker2_validate	-0.756804640103008	6.86430966643839e-38		NA	NA	NA
hsa-miR-484	SPHK1	0.349444060004737	0.00154491249625173	0.753422591953572	8.59725157968045e-08	miRNAWalker2_validate	-0.15427858145266	0.000457016288320566		NA	NA	NA
hsa-miR-16-5p	SPHK2	0.46835991343556	1.91125356547776e-06	0.706094211869426	4.02352204528931e-17	mirMAP	-0.175357613478155	2.91068209903702e-09		NA	NA	NA
hsa-miR-28-5p	SPHK2	-0.14267073663385	0.0497619246260571	0.706094211869426	4.02352204528931e-17	mirMAP	-0.232571634666738	8.87397180654698e-09		NA	NA	NA
hsa-miR-324-3p	SPHK2	0.404877731996915	0.000340036423920834	0.706094211869426	4.02352204528931e-17	PITA;miRNATAP	-0.147080139335765	1.12471367351561e-08		NA	NA	NA
hsa-miR-324-5p	SPHK2	0.211552647440779	0.139408130311654	0.706094211869426	4.02352204528931e-17	miRanda;mirMAP;miRNATAP	-0.100585871533664	8.25900147764136e-07		NA	NA	NA
hsa-miR-326	SPHK2	-1.54449030848141	1.04703417845594e-17	0.706094211869426	4.02352204528931e-17	mirMAP	-0.193423765659583	7.59033228444339e-37		NA	NA	NA
hsa-miR-424-5p	SPHK2	0.420789584199235	0.00480101660479489	0.706094211869426	4.02352204528931e-17	mirMAP	-0.149323131188234	1.13684802055569e-14		NA	NA	NA
hsa-miR-455-3p	SPHK2	0.678392920628872	0.000327758844555877	0.706094211869426	4.02352204528931e-17	mirMAP	-0.106262175106562	3.63146680905758e-12		NA	NA	NA
hsa-miR-484	SPHK2	0.349444060004737	0.00154491249625173	0.706094211869426	4.02352204528931e-17	miRNATAP	-0.159814794127736	1.35228568705932e-09		NA	NA	NA
hsa-miR-509-3p	SPHK2	-0.297640677606955	0.0918863554685451	0.706094211869426	4.02352204528931e-17	miRNATAP	-0.139818427079598	1.90435649664879e-17		NA	NA	NA
hsa-miR-708-5p	SPHK2	0.638386255192461	1.19735143565146e-06	0.706094211869426	4.02352204528931e-17	mirMAP	-0.122744322667054	2.59377578006766e-08		NA	NA	NA
hsa-miR-10b-3p	SRC	-1.58463104907636	1.17335119858099e-46	0.921384178248314	6.35594493285215e-29	MirTarget	-0.210081744996226	1.4103117868264e-17		NA	NA	NA
hsa-miR-195-5p	SRC	-1.47508108420708	2.20685847368258e-38	0.921384178248314	6.35594493285215e-29	mirMAP	-0.19322159585392	1.3606593553799e-15		NA	NA	NA
hsa-miR-491-5p	SRC	-1.04307210952796	1.14586501470398e-15	0.921384178248314	6.35594493285215e-29	MirTarget;miRanda	-0.139499539652282	2.61956398673257e-10		NA	NA	NA
hsa-miR-101-3p	VEGFA	-0.126035286271986	0.145997832808138	0.558196398264416	4.82412858140541e-08	miRNAWalker2_validate	-0.244521682678937	1.84891665047835e-09		NA	NA	NA
hsa-miR-134-5p	VEGFA	-0.943054080774898	1.50079821035544e-12	0.558196398264416	4.82412858140541e-08	miRNAWalker2_validate;miRTarBase;MirTarget	-0.167128564426745	1.10726961805336e-10		NA	NA	NA
hsa-miR-150-5p	VEGFA	-0.832049526091211	3.45299201139224e-05	0.558196398264416	4.82412858140541e-08	miRNAWalker2_validate;miRTarBase	-0.151371862718652	1.00198904514709e-18		NA	NA	NA
hsa-miR-195-5p	VEGFA	-1.47508108420708	2.20685847368258e-38	0.558196398264416	4.82412858140541e-08	miRNAWalker2_validate;miRTarBase;MirTarget	-0.218575701645509	7.55403373439709e-14	27574422;23468064;26823724	In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC	;;metastasis	liver cancer;liver cancer;liver cancer
hsa-miR-199a-5p	VEGFA	-0.314703593105081	0.00909304983051124	0.558196398264416	4.82412858140541e-08	miRanda;miRNATAP	-0.179279483927549	6.72134651164296e-10	25444917	In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo		sarcoma
hsa-miR-199b-5p	VEGFA	-1.37022396448377	3.25758057539223e-26	0.558196398264416	4.82412858140541e-08	miRanda	-0.228409524155996	1.33793206666423e-18		NA	NA	NA
hsa-miR-29a-3p	VEGFA	-0.699539666833076	1.13935003139957e-13	0.558196398264416	4.82412858140541e-08	MirTarget	-0.114785243382774	0.00196474782587542	24209632	miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A		gastric cancer
hsa-miR-29c-3p	VEGFA	-0.0652732378039769	0.563774115756922	0.558196398264416	4.82412858140541e-08	miRNAWalker2_validate;MirTarget	-0.126355371943564	5.32172855437951e-05		NA	NA	NA
hsa-miR-335-5p	VEGFA	-2.61355235628987	2.6462884165886e-51	0.558196398264416	4.82412858140541e-08	miRNAWalker2_validate	-0.103950468396491	4.59347799365143e-08		NA	NA	NA
hsa-miR-497-5p	VEGFA	-1.4667331575679	5.49909921822638e-36	0.558196398264416	4.82412858140541e-08	MirTarget	-0.126722638387264	1.08881401780323e-05	26718330;26485685;26336827;26202364;27015364;25176450;26840372	Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497	;;metastasis;;;;	breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer