miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-141-3p DTL -5.87110686537457 1.20877726722907e-85 2.69335279805375 1.08205353607758e-54 MirTarget -0.333272168796876 1.1183867833092e-37 NA NA NA hsa-miR-200a-3p DTL -1.43409013664263 2.00188483717828e-20 2.69335279805375 1.08205353607758e-54 MirTarget -0.482296945357559 4.30340271131934e-13 NA NA NA hsa-miR-217 DTL -1.32414431829977 4.20138196453017e-06 2.69335279805375 1.08205353607758e-54 miRanda -0.180465741294889 2.6406095538323e-06 NA NA NA hsa-miR-30a-3p DTL -0.955360819934585 1.97009535429185e-20 2.69335279805375 1.08205353607758e-54 MirTarget -0.847810557350194 9.56261948270899e-18 22287560 MiR 30a 5p suppresses tumor growth in colon carcinoma by targeting DTL colon cancer hsa-miR-30a-5p DTL -0.778411951775343 2.73322451127932e-16 2.69335279805375 1.08205353607758e-54 miRNAWalker2_validate;miRTarBase -0.860477302786421 4.69359470890013e-15 22287560 MiR 30a 5p suppresses tumor growth in colon carcinoma by targeting DTL; Subsequent reporter gene assays confirmed the predicted miR-30a-5p binding site in the 3'untranslated region of DTL; In conclusion our data identified miR-30a-5p as a tumor-suppressing miRNA in colon cancer cells exerting its function via modulation of DTL expression which is frequently overexpressed in colorectal cancer colon cancer hsa-miR-30d-3p DTL -0.249777194282131 0.00235356711813496 2.69335279805375 1.08205353607758e-54 MirTarget -0.671794138579104 9.83557294739525e-07 NA NA NA hsa-miR-30e-3p DTL -0.205602546270795 0.00132666419729688 2.69335279805375 1.08205353607758e-54 MirTarget -0.550938290937164 0.00214820978518375 NA NA NA hsa-miR-577 DTL -1.48881999472397 7.03080165111147e-10 2.69335279805375 1.08205353607758e-54 mirMAP -0.165845710450841 0.000285797538216374 NA NA NA hsa-miR-96-5p DTL -1.00223771166604 3.91564621567028e-06 2.69335279805375 1.08205353607758e-54 TargetScan -0.111265681912012 0.0365293128550954 NA NA NA