miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-708-3p APAF1 0.137785606206693 0.896980471394499 -0.173549826698829 0.88665142839701 mirMAP -0.105643259572274 0.00109765096412761 NA NA NA hsa-miR-324-5p ATM -0.50063248413014 0.537416710557032 0.191778405096067 0.864625288192543 miRanda -0.12216548800381 0.00154765973160933 NA NA NA hsa-miR-455-5p ATM -0.139599153671262 0.865744220236311 0.191778405096067 0.864625288192543 miRanda -0.119520466419818 0.00128133661552861 NA NA NA hsa-miR-590-5p ATM -0.547819833829572 0.472735645776647 0.191778405096067 0.864625288192543 mirMAP -0.103121093611562 0.00141721793607095 NA NA NA hsa-miR-30a-5p CASP3 0.219472325612346 0.933954023293816 -0.162965782047655 0.903158908366085 miRNATAP -0.203229832372977 5.73122351633379e-05 NA NA NA hsa-miR-143-3p CASP8 0.371591944134735 0.927341352649583 -0.268951646645792 0.828588317117104 MirTarget -0.109420620201972 0.000545823380266859 NA NA NA hsa-miR-133b CCNB1 0.392161188688359 0.560763234081075 -0.279098563483175 0.850128792274294 miRanda -0.131334287060603 4.50924766509396e-07 NA NA NA hsa-miR-139-5p CCNB1 -0.0810891026597322 0.928690377743652 -0.279098563483175 0.850128792274294 miRanda -0.183097769909703 0.000837427712249749 NA NA NA hsa-let-7c-5p CCNB2 -0.0629831812743404 0.974895834249241 -0.204202709262817 0.87077526103075 miRNAWalker2_validate -0.18504849986348 3.20172665876533e-07 NA NA NA hsa-miR-23b-3p CCNB2 -0.10822254818704 0.961352920317636 -0.204202709262817 0.87077526103075 miRNAWalker2_validate -0.330014695854348 0.000111146411555414 NA NA NA hsa-miR-16-5p CCND1 0.0135949734723564 0.994476223855607 -0.254128537418143 0.890666103231997 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.131352085119981 0.00823300401924536 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-195-5p CCND1 0.343201952346823 0.749622318650888 -0.254128537418143 0.890666103231997 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.135964440478054 0.00272099018653157 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-29c-3p CCND1 0.162451700202704 0.942720457512509 -0.254128537418143 0.890666103231997 mirMAP -0.140688238276882 0.00181263740987372 NA NA NA hsa-miR-125b-5p CCNE1 0.042694645848468 0.980586836124662 -0.280205935660748 0.736508482635676 miRNAWalker2_validate -0.153080131670566 0.000743418271995361 NA NA NA hsa-miR-195-5p CCNE1 0.343201952346823 0.749622318650888 -0.280205935660748 0.736508482635676 miRNAWalker2_validate;MirTarget;miRNATAP -0.17512748753993 0.0030220881483402 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-26a-5p CCNE2 0.00698202897993028 0.997719986197021 -0.154004923605453 0.847304727818299 miRNAWalker2_validate;miRTarBase;miRNATAP -0.357013460089754 0.000842485602706472 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-30a-5p CCNE2 0.219472325612346 0.933954023293816 -0.154004923605453 0.847304727818299 miRNATAP -0.438624147963128 1.0101110606114e-07 NA NA NA hsa-miR-34a-5p CCNE2 -0.50188164870224 0.742034237185732 -0.154004923605453 0.847304727818299 miRNAWalker2_validate;miRTarBase;miRNATAP -0.220025402098138 0.000175922127494152 NA NA NA hsa-miR-34c-5p CCNE2 -0.018707656771723 0.952788306178575 -0.154004923605453 0.847304727818299 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.275859200004622 3.23513835152069e-07 NA NA NA hsa-let-7c-5p CCNG1 -0.0629831812743404 0.974895834249241 -0.0175189243950067 0.991103330530897 miRNAWalker2_validate -0.111792645234037 0.00148577649834627 NA NA NA hsa-let-7e-5p CCNG1 0.211156073215582 0.922335699862928 -0.0175189243950067 0.991103330530897 miRNAWalker2_validate -0.226134919093892 0.000817619431442279 NA NA NA hsa-miR-100-5p CCNG1 0.0230258429671419 0.992818348620337 -0.0175189243950067 0.991103330530897 miRNAWalker2_validate -0.122150346233984 0.000747967078030819 NA NA NA hsa-miR-23b-3p CCNG1 -0.10822254818704 0.961352920317636 -0.0175189243950067 0.991103330530897 MirTarget;miRNATAP -0.216096235840365 0.00859618344490524 26872615 MiR 23b targets cyclin G1 and suppresses ovarian cancer tumorigenesis and progression; Dual-luciferase reporter assay and a xenograft mouse model were used to examine the expression of miR-23b and its target gene CCNG1; Dual-luciferase reporter assay showed that miR-23b bound with the 3' untranslated region of CCNG1; Furthermore miR-23b inhibited tumor growth and suppressed CCNG1 expression in vitro; Our findings show that miR-23b may inhibit ovarian cancer tumorigenesis and progression by downregulating CCNG1 and the expression of the relevant genes progression;tumorigenesis ovarian cancer hsa-miR-106a-5p CCNG2 -0.203919267842652 0.802213958426804 -0.105546505734094 0.929336484284765 MirTarget;miRNATAP -0.125268547952124 0.00133605170160376 NA NA NA hsa-miR-106b-5p CCNG2 -0.297128724729339 0.869294443540749 -0.105546505734094 0.929336484284765 MirTarget;miRNATAP -0.124660217776742 0.00599025989804996 NA NA NA hsa-miR-17-5p CCNG2 -0.175448849583061 0.934544015912731 -0.105546505734094 0.929336484284765 MirTarget;TargetScan;miRNATAP -0.147666244100562 1.51005151798703e-05 NA NA NA hsa-miR-20a-5p CCNG2 -0.179153323927949 0.928118119139752 -0.105546505734094 0.929336484284765 MirTarget;miRNATAP -0.122920339291083 0.000279760685586677 NA NA NA hsa-miR-224-5p CCNG2 -0.240425158977724 0.857351098476517 -0.105546505734094 0.929336484284765 mirMAP -0.130222420782481 4.90398207914239e-06 NA NA NA hsa-miR-29a-5p CCNG2 -0.31835175571979 0.600442757817281 -0.105546505734094 0.929336484284765 mirMAP -0.10609268143791 0.00322479920073133 NA NA NA hsa-miR-331-5p CCNG2 -0.450673082073933 0.250361590873666 -0.105546505734094 0.929336484284765 miRNATAP -0.116391205744589 0.00824303014548495 NA NA NA hsa-miR-335-3p CCNG2 -0.244830745789445 0.88450019116631 -0.105546505734094 0.929336484284765 MirTarget;mirMAP -0.156769870396619 1.03298824180011e-05 NA NA NA hsa-miR-503-5p CCNG2 0.181411121123657 0.766398160421164 -0.105546505734094 0.929336484284765 miRNAWalker2_validate -0.101717511038364 0.000273157558071928 NA NA NA hsa-miR-93-5p CCNG2 -0.611073677204699 0.825297877093193 -0.105546505734094 0.929336484284765 miRNAWalker2_validate;MirTarget;miRNATAP -0.137509894680822 0.00128970345572342 NA NA NA hsa-miR-23b-3p CDK2 -0.10822254818704 0.961352920317636 -0.00941560099946681 0.994105531325921 miRNAWalker2_validate -0.171002677486014 0.00275427306255561 NA NA NA hsa-miR-195-5p CDK4 0.343201952346823 0.749622318650888 -0.0555656491892718 0.974291102166537 miRNAWalker2_validate;miRTarBase -0.178739487005888 1.99144590740755e-06 NA NA NA hsa-miR-34c-5p CDK4 -0.018707656771723 0.952788306178575 -0.0555656491892718 0.974291102166537 miRNAWalker2_validate;miRTarBase -0.109354693621618 0.0030808277323941 NA NA NA hsa-miR-21-5p CDK6 -0.148920887107433 0.970240620972126 0.263751741096359 0.851495006493897 miRNAWalker2_validate;mirMAP -0.322969883377914 4.63783733839343e-05 NA NA NA hsa-miR-22-3p CDK6 0.0592693913158495 0.986564295498741 0.263751741096359 0.851495006493897 miRNAWalker2_validate -0.265335616194499 0.00120632355440899 NA NA NA hsa-let-7c-5p CDKN1A -0.0629831812743404 0.974895834249241 0.0967867865725873 0.953141906484364 MirTarget -0.152073389305065 0.0033021603310084 NA NA NA hsa-miR-101-3p CDKN1A 0.0107754887734437 0.997036362636866 0.0967867865725873 0.953141906484364 MirTarget -0.403803292172332 3.96045856328491e-05 NA NA NA hsa-miR-708-5p CDKN1A -0.0282907993048824 0.974929832201158 0.0967867865725873 0.953141906484364 MirTarget -0.137894178596668 0.00964228236869156 NA NA NA hsa-let-7g-5p CDKN2A -0.200947212961157 0.922992045181955 1.38311764888886 0.0180278819048057 miRNAWalker2_validate;miRTarBase -0.535554308915819 0.00297017801707372 NA NA NA hsa-miR-139-5p CHEK1 -0.0810891026597322 0.928690377743652 -0.282075347316236 0.78553656972735 miRanda -0.13247727540385 0.00213446723619324 NA NA NA hsa-miR-195-5p CHEK1 0.343201952346823 0.749622318650888 -0.282075347316236 0.78553656972735 MirTarget;miRNATAP -0.157301144457684 0.000252651965237698 25840419 MiR 195 suppresses non small cell lung cancer by targeting CHEK1; We discovered that CHEK1 was a direct target of miR-195 which decreased CHEK1 expression in lung cancer cells lung squamous cell cancer hsa-miR-497-5p CHEK1 -0.0120217191428731 0.989147225742026 -0.282075347316236 0.78553656972735 MirTarget;miRNATAP -0.205994264459408 4.95603777290773e-05 24464213 Checkpoint kinase 1 is negatively regulated by miR 497 in hepatocellular carcinoma; In silico analysis showed that CHEK1 was a candidate target of miR-497 which was previously found to be downregulated in HCC by us; To test whether miR-497 could bind to 3'untranslated region 3'UTR of CHEK1 luciferase reporter assay was conducted; The result revealed that miR-497 could bind to the 3'untranslated region 3'UTR of CHEK1 mRNA; Western blot showed that ectopic expression of miR-497 suppressed the CHEK1 expression and inhibition of miR-497 led to significant upregulation of CHEK1; Finally miR-497 expression was measured in the same 30 HCC samples and the correlation between miR-497 and CHEK1 was analyzed; The results indicated that miR-497 was downregulated in HCC and had a significant negative correlation with CHEK1; Taken together these results demonstrated that CHEK1 was negatively regulated by miR-497 and the overexpressed CHEK1 was resulted from the downregulated miR-497 in HCC which provided a potential molecular target for HCC therapy liver cancer hsa-miR-139-5p CYCS -0.0810891026597322 0.928690377743652 -0.0801546909855499 0.965739955684414 miRanda -0.180455845650641 6.81104021035486e-05 NA NA NA hsa-miR-34c-3p CYCS -0.0677097368202059 0.825448151326958 -0.0801546909855499 0.965739955684414 mirMAP -0.100294994424538 0.00799698860616829 NA NA NA hsa-miR-34c-5p CYCS -0.018707656771723 0.952788306178575 -0.0801546909855499 0.965739955684414 miRanda -0.158065264009806 0.000330182557876286 NA NA NA hsa-miR-106a-5p FAS -0.203919267842652 0.802213958426804 -0.347166376396346 0.702810017457386 miRNAWalker2_validate;miRTarBase -0.309397365527179 1.69760652678533e-06 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-361-5p FAS -0.138735309928775 0.941495130308343 -0.347166376396346 0.702810017457386 miRanda -0.421714311791871 0.000155426639121472 NA NA NA hsa-miR-590-5p FAS -0.547819833829572 0.472735645776647 -0.347166376396346 0.702810017457386 miRanda -0.168205409634763 0.00402598857592482 NA NA NA hsa-miR-98-5p FAS -0.168162186023221 0.898802461503524 -0.347166376396346 0.702810017457386 miRNAWalker2_validate -0.378145247947084 2.09454221266366e-05 NA NA NA hsa-miR-324-3p GADD45B -0.424387380347173 0.661528309116338 0.524578686880012 0.613526698742649 MirTarget;miRNATAP -0.215175591383005 0.00285407658213762 NA NA NA hsa-miR-590-3p GADD45B -0.279244755376859 0.59126669933662 0.524578686880012 0.613526698742649 miRanda -0.228270935470796 2.64404491951025e-06 NA NA NA hsa-miR-181c-5p GTSE1 0.042951891660695 0.969159991881861 -0.252494926390392 0.808313293125948 MirTarget -0.197804475800146 3.59496813731752e-05 NA NA NA hsa-let-7a-3p IGF1 -0.215598045625677 0.85543299203799 0.00947737435165086 0.987467926907962 mirMAP -1.080447980324 1.8079365656541e-11 NA NA NA hsa-let-7f-1-3p IGF1 -0.31101436822914 0.693407210545374 0.00947737435165086 0.987467926907962 mirMAP -1.33703011462655 1.62041677524579e-09 NA NA NA hsa-miR-1275 IGF1 -0.831342050607648 0.0803795852164229 0.00947737435165086 0.987467926907962 MirTarget;PITA -0.38101781548121 5.45983739511041e-05 NA NA NA hsa-miR-130b-3p IGF1 -0.221667315324818 0.824660172394714 0.00947737435165086 0.987467926907962 MirTarget -1.32997411476354 1.36901225432237e-20 NA NA NA hsa-miR-148a-5p IGF1 -0.448099743845604 0.748419139652266 0.00947737435165086 0.987467926907962 mirMAP -0.731184313112099 6.87872094016325e-07 NA NA NA hsa-miR-15b-3p IGF1 -0.557749208157585 0.609181305423188 0.00947737435165086 0.987467926907962 mirMAP -1.37193595831155 3.68702917896959e-22 NA NA NA hsa-miR-16-1-3p IGF1 0.151694812889216 0.733736501874638 0.00947737435165086 0.987467926907962 mirMAP -0.870110401826923 9.48782291894495e-12 NA NA NA hsa-miR-186-5p IGF1 -0.318786974828757 0.85412722938961 0.00947737435165086 0.987467926907962 mirMAP -1.35027272960641 3.80273001614756e-11 NA NA NA hsa-miR-19a-3p IGF1 -0.206793507801887 0.844637784802316 0.00947737435165086 0.987467926907962 MirTarget -0.98551271469101 4.98535421174768e-17 NA NA NA hsa-miR-19b-1-5p IGF1 -0.0105982583216702 0.988511655226679 0.00947737435165086 0.987467926907962 mirMAP -0.955450359137311 6.7696545868365e-13 NA NA NA hsa-miR-19b-3p IGF1 -0.0268530183621474 0.986656783046572 0.00947737435165086 0.987467926907962 MirTarget -1.18511578469291 3.16855554305294e-17 NA NA NA hsa-miR-20a-3p IGF1 0.456808229166028 0.57674056136504 0.00947737435165086 0.987467926907962 mirMAP -0.828202370369737 4.46601232058444e-17 NA NA NA hsa-miR-224-3p IGF1 0.110372723153393 0.749091467231007 0.00947737435165086 0.987467926907962 mirMAP -0.323141310332858 0.00752558553987227 NA NA NA hsa-miR-26b-5p IGF1 -0.0245931278499594 0.990377966314923 0.00947737435165086 0.987467926907962 mirMAP -1.32653848815452 7.59461749262891e-12 NA NA NA hsa-miR-27a-3p IGF1 -0.123902317731458 0.958804393510999 0.00947737435165086 0.987467926907962 miRNAWalker2_validate;miRTarBase -1.33297141089179 1.59629899773494e-08 NA NA NA hsa-miR-29a-3p IGF1 0.01127474410284 0.996977020481272 0.00947737435165086 0.987467926907962 MirTarget -1.21646810613425 2.24809293601906e-10 NA NA NA hsa-miR-29b-3p IGF1 -0.104016192263954 0.958988036765397 0.00947737435165086 0.987467926907962 MirTarget -1.13478255405874 1.02581838525823e-15 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 -0.105312511901769 0.831686745977347 0.00947737435165086 0.987467926907962 MirTarget -0.72462477830808 1.53712615625093e-08 NA NA NA hsa-miR-32-3p IGF1 -0.568003960723004 0.13133163420273 0.00947737435165086 0.987467926907962 mirMAP -0.854296588628844 6.36098490896109e-17 NA NA NA hsa-miR-320a IGF1 -0.416546433767628 0.840202138616422 0.00947737435165086 0.987467926907962 miRNATAP -0.53324783195833 0.00309104675893166 NA NA NA hsa-miR-33a-3p IGF1 -0.794543849238581 0.0105203072007922 0.00947737435165086 0.987467926907962 MirTarget -0.712659254532177 1.07475387901444e-08 NA NA NA hsa-miR-361-5p IGF1 -0.138735309928775 0.941495130308343 0.00947737435165086 0.987467926907962 PITA;mirMAP -0.7571457599163 0.00312625171582628 NA NA NA hsa-miR-362-5p IGF1 -0.26647467080141 0.752024885130738 0.00947737435165086 0.987467926907962 mirMAP -0.685362314110393 1.45434246224861e-09 NA NA NA hsa-miR-369-3p IGF1 0.116576891957687 0.83230082995912 0.00947737435165086 0.987467926907962 mirMAP -0.416113550798216 0.00731803332568262 NA NA NA hsa-miR-374b-3p IGF1 -0.0542885924440247 0.860753623992354 0.00947737435165086 0.987467926907962 mirMAP -0.901177033447461 2.85340453160353e-08 NA NA NA hsa-miR-376b-3p IGF1 -0.00712550627858333 0.982426403308526 0.00947737435165086 0.987467926907962 mirMAP -0.400180241759986 0.00219046891964139 NA NA NA hsa-miR-377-3p IGF1 -0.0435868040110954 0.893514136702459 0.00947737435165086 0.987467926907962 mirMAP -0.347398016761275 0.00944572443583628 NA NA NA hsa-miR-421 IGF1 -0.182032017078616 0.734704500318599 0.00947737435165086 0.987467926907962 PITA -0.682640976463619 1.66568557959283e-06 NA NA NA hsa-miR-450b-5p IGF1 -0.0136687538973108 0.983149761399849 0.00947737435165086 0.987467926907962 MirTarget;PITA;mirMAP;miRNATAP -0.440274691286941 0.00526886632157137 NA NA NA hsa-miR-452-5p IGF1 -0.0504626418153507 0.973874641360401 0.00947737435165086 0.987467926907962 MirTarget;mirMAP -0.391677573462921 0.00721587803462884 NA NA NA hsa-miR-454-3p IGF1 -0.101514866328011 0.843545158256191 0.00947737435165086 0.987467926907962 MirTarget -1.21083489236632 2.3904507521785e-12 NA NA NA hsa-miR-486-5p IGF1 -0.547739229538641 0.696404149927963 0.00947737435165086 0.987467926907962 PITA;miRNATAP -0.27962476093108 0.00602263294023068 NA NA NA hsa-miR-576-5p IGF1 -0.506413219377403 0.417187951364173 0.00947737435165086 0.987467926907962 PITA;mirMAP;miRNATAP -1.07532866336442 7.30778925637395e-14 NA NA NA hsa-miR-577 IGF1 -1.06238199218774 0.326056761787754 0.00947737435165086 0.987467926907962 PITA -0.608739982603203 1.28953846721018e-16 NA NA NA hsa-miR-590-3p IGF1 -0.279244755376859 0.59126669933662 0.00947737435165086 0.987467926907962 MirTarget;miRanda;mirMAP;miRNATAP -0.902455239090903 4.54122052117076e-14 NA NA NA hsa-miR-592 IGF1 -0.177670083168544 0.856226890424691 0.00947737435165086 0.987467926907962 mirMAP -0.176568829642714 0.00558894888386371 NA NA NA hsa-miR-629-5p IGF1 -0.385679366494342 0.798536530066869 0.00947737435165086 0.987467926907962 mirMAP -0.580583415149519 2.61578695347913e-05 NA NA NA hsa-miR-940 IGF1 -0.225788347550697 0.680055767105815 0.00947737435165086 0.987467926907962 MirTarget;PITA;miRNATAP -0.565084064749585 9.24954782359072e-08 NA NA NA hsa-let-7a-3p IGFBP3 -0.215598045625677 0.85543299203799 0.568859949215387 0.726718119187306 miRNATAP -0.427943062808335 1.71361067788621e-07 NA NA NA hsa-miR-197-3p IGFBP3 -0.455489147957159 0.794916582095149 0.568859949215387 0.726718119187306 MirTarget;miRNATAP -0.349341296737247 1.652292428202e-05 NA NA NA hsa-miR-19a-3p IGFBP3 -0.206793507801887 0.844637784802316 0.568859949215387 0.726718119187306 MirTarget;miRNATAP -0.413863966875631 5.94955459313678e-12 NA NA NA hsa-miR-19b-3p IGFBP3 -0.0268530183621474 0.986656783046572 0.568859949215387 0.726718119187306 MirTarget;miRNATAP -0.484794054569635 1.78591235422059e-11 NA NA NA hsa-miR-224-5p IGFBP3 -0.240425158977724 0.857351098476517 0.568859949215387 0.726718119187306 MirTarget -0.302203089681158 2.07729224650049e-08 NA NA NA hsa-miR-339-5p IGFBP3 -0.300425087100667 0.712912847076788 0.568859949215387 0.726718119187306 miRanda -0.32381423148184 8.61985294739167e-08 NA NA NA hsa-miR-374a-5p IGFBP3 -0.343007247142618 0.766921280269271 0.568859949215387 0.726718119187306 MirTarget;mirMAP -0.503487080673234 2.20821370527862e-06 NA NA NA hsa-miR-374b-5p IGFBP3 -0.285682091626878 0.83569830479965 0.568859949215387 0.726718119187306 MirTarget -0.544272281788339 1.08163089699587e-07 NA NA NA hsa-miR-375 IGFBP3 -0.690952835064582 0.831716365337668 0.568859949215387 0.726718119187306 miRNAWalker2_validate -0.167059107556288 0.000458496903519815 NA NA NA hsa-miR-590-3p IGFBP3 -0.279244755376859 0.59126669933662 0.568859949215387 0.726718119187306 miRanda -0.334718487778461 5.3661116506107e-08 NA NA NA hsa-miR-590-5p IGFBP3 -0.547819833829572 0.472735645776647 0.568859949215387 0.726718119187306 miRanda -0.416847919531482 8.25393683151095e-11 NA NA NA hsa-miR-143-3p MDM2 0.371591944134735 0.927341352649583 -0.485742577574077 0.723491564717608 miRNAWalker2_validate -0.16317524344501 0.00124362026384159 NA NA NA hsa-let-7b-5p MDM4 -0.228773940533783 0.938952933213741 0.247515732034583 0.823180116354759 miRNAWalker2_validate;MirTarget -0.144698302584545 0.0044438028833445 NA NA NA hsa-miR-150-5p PERP -0.380115629777847 0.838788934042507 0.228909067758977 0.911265370362317 MirTarget -0.168580306893967 3.01817997740684e-06 NA NA NA hsa-miR-629-3p PERP -0.495402745812008 0.333967382214384 0.228909067758977 0.911265370362317 MirTarget -0.12160568922243 0.00543013951132401 NA NA NA hsa-miR-200b-3p PMAIP1 -0.426401948379212 0.863957108574195 0.0221713690343401 0.980321069097491 MirTarget;TargetScan -0.151563048354964 0.00941366494234733 NA NA NA hsa-miR-195-5p PPM1D 0.343201952346823 0.749622318650888 -0.188334095341044 0.83465151453017 MirTarget;miRNATAP -0.101767389075739 0.00097111293592588 NA NA NA hsa-miR-26b-5p PPM1D -0.0245931278499594 0.990377966314923 -0.188334095341044 0.83465151453017 miRNAWalker2_validate -0.12055985100275 0.0026345476659274 NA NA NA hsa-miR-29a-3p PPM1D 0.01127474410284 0.996977020481272 -0.188334095341044 0.83465151453017 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.157901298228283 5.2861829298238e-05 NA NA NA hsa-miR-29b-3p PPM1D -0.104016192263954 0.958988036765397 -0.188334095341044 0.83465151453017 MirTarget;miRNATAP -0.111868701934817 0.000161382626807274 NA NA NA hsa-miR-106a-5p PTEN -0.203919267842652 0.802213958426804 -0.271908314083064 0.8445980026244 miRNATAP -0.135133363016591 0.00145239050346874 26097565;26318586 miR 106a promotes growth and metastasis of non small cell lung cancer by targeting PTEN; Furthermore the presence of miR-106a was inversely correlated with PTEN in NSCLC tissues; Overall this study suggested that miR-106a inhibited the growth and metastasis of NSCLC cells by decreasing PTEN expression;Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo metastasis; lung squamous cell cancer;prostate cancer hsa-miR-188-5p PTEN -0.568517670542551 0.324820848307954 -0.271908314083064 0.8445980026244 MirTarget;PITA;miRNATAP -0.101903000516257 0.0012689580885123 NA NA NA hsa-miR-29b-3p PTEN -0.104016192263954 0.958988036765397 -0.271908314083064 0.8445980026244 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.118521083357978 0.00549994580612497 26471361;23179556;26063204;21359530 Mechanistically ATDC exerted its oncogenic effects by suppressing miR-29 and subsequent upregulation of DNMT3A leading to DNA methylation and silencing of the tumor suppressor PTEN;Anticancer role of MUC1 aptamer miR 29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation; Our study indicated that Chi-29b chimera can effectively exert antitumor effect through specific delivery of miR-29b into OVCAR-3 tumor cells subsequently reexpressing PTEN gene and inducing cell apoptosis;Furthermore the dual-luciferase reporter assay demonstrated that miR-29b inhibited the expression of the luciferase gene containing the 3'-UTRs of MMP2 and PTEN mRNA;In contrast enhanced miR-29b expression by transfection with pre-miR-29b decreased the expression of PTEN and impaired apoptosis increasing tumor cell migration and invasion; Moreover PTEN was shown to be a direct target of miR-29b and was also shown to contribute to the miR-29b-mediated effects on cell invasion; Modulation of miR-29b altered the role of PTEN involved in cell migration and invasion; Aberrant expression of miR-29b which modulates PTEN expression can contribute to migration invasion and anti-apoptosis ;;;cell migration bladder cancer;ovarian cancer;lung squamous cell cancer;breast cancer hsa-miR-146b-5p RFWD2 -0.402662509440887 0.837510937985091 0.128329167645872 0.923542666239354 miRNATAP -0.123351611061266 3.500712466915e-05 NA NA NA hsa-miR-338-3p RPRM 0.49158501750012 0.788483749194189 0.526784039775591 0.54343511201096 miRanda -0.361826296726167 0.00289486121587046 NA NA NA hsa-miR-375 RPRM -0.690952835064582 0.831716365337668 0.526784039775591 0.54343511201096 miRanda -0.497763379379546 1.02883407530703e-06 NA NA NA hsa-miR-501-3p RPRM -0.753812576327832 0.552763280802254 0.526784039775591 0.54343511201096 miRNATAP -0.620102662416824 3.5669668316071e-05 NA NA NA hsa-miR-100-5p RRM2 0.0230258429671419 0.992818348620337 -0.250742317309673 0.87456231901039 miRNAWalker2_validate -0.249955735053857 1.22960891536388e-09 NA NA NA hsa-miR-125a-5p RRM2 -0.00183986061615382 0.999158100170883 -0.250742317309673 0.87456231901039 miRanda -0.266698830744831 9.40818883718848e-05 NA NA NA hsa-miR-199a-5p RRM2 0.157247797504494 0.935797462797012 -0.250742317309673 0.87456231901039 miRanda -0.236869154309022 4.43039475625009e-05 NA NA NA hsa-miR-199b-5p RRM2 -0.0396557270992508 0.977172718873203 -0.250742317309673 0.87456231901039 miRanda -0.150253297387943 0.0032114636153773 NA NA NA hsa-miR-217 RRM2 0.341080669095094 0.760998144794468 -0.250742317309673 0.87456231901039 miRanda -0.201464372299675 1.84349016615563e-07 NA NA NA hsa-miR-26a-5p RRM2 0.00698202897993028 0.997719986197021 -0.250742317309673 0.87456231901039 miRNAWalker2_validate -0.42099143830562 3.34298190980887e-05 NA NA NA hsa-miR-30a-5p RRM2 0.219472325612346 0.933954023293816 -0.250742317309673 0.87456231901039 miRNAWalker2_validate -0.502911958028424 8.65396043586857e-11 NA NA NA hsa-miR-140-5p RRM2B -0.229213026275906 0.847330111738616 -0.416751393249413 0.72245152441626 miRanda -0.175854996580872 0.00211117543150878 NA NA NA hsa-miR-142-3p RRM2B -0.154235241441331 0.946098054588918 -0.416751393249413 0.72245152441626 miRNAWalker2_validate;miRanda -0.148950435377419 2.15666356407577e-06 NA NA NA hsa-miR-30e-5p RRM2B -0.0657075181381011 0.979684509181941 -0.416751393249413 0.72245152441626 mirMAP -0.185956887742994 0.00222873385796031 NA NA NA hsa-miR-369-3p RRM2B 0.116576891957687 0.83230082995912 -0.416751393249413 0.72245152441626 mirMAP -0.106780726844911 0.00769408203496214 NA NA NA hsa-miR-495-3p RRM2B 0.00168200867117596 0.997533662527025 -0.416751393249413 0.72245152441626 mirMAP -0.170842386112516 0.000498062362394788 NA NA NA hsa-miR-7-1-3p RRM2B -0.462485777435991 0.665899751398166 -0.416751393249413 0.72245152441626 mirMAP -0.164252360895858 1.35618072549855e-05 NA NA NA hsa-miR-335-5p SERPINB5 -0.0284895175847679 0.973380867832231 0.997378164577824 0.445912083904007 miRNAWalker2_validate -0.584662932712155 0.000115176833978713 NA NA NA hsa-miR-148a-3p SERPINE1 -0.101286586375016 0.976980454193186 0.96681951287161 0.431832134223424 miRNATAP -0.632556271552535 5.26029254260156e-10 NA NA NA hsa-miR-148a-5p SERPINE1 -0.448099743845604 0.748419139652266 0.96681951287161 0.431832134223424 miRNATAP -0.48504282951706 1.21612122671234e-06 NA NA NA hsa-miR-2110 SERPINE1 -0.317803483266315 0.250981343062022 0.96681951287161 0.431832134223424 miRNATAP -0.26348450340175 0.0081373992329162 NA NA NA hsa-miR-301a-3p SERPINE1 -0.105312511901769 0.831686745977347 0.96681951287161 0.431832134223424 miRNAWalker2_validate;miRTarBase -0.396018779464475 6.73615174336987e-06 NA NA NA hsa-miR-30b-5p SERPINE1 -0.0121430518253582 0.994622896704513 0.96681951287161 0.431832134223424 MirTarget -0.507157165902896 2.79773286100547e-07 25170877 miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells gastric cancer hsa-miR-30c-5p SERPINE1 -0.298383882401475 0.865809030482001 0.96681951287161 0.431832134223424 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.661867842175139 3.31961148001324e-06 NA NA NA hsa-miR-30d-5p SERPINE1 -0.168211838771867 0.95173197030375 0.96681951287161 0.431832134223424 miRNATAP -0.62115706519577 1.17628403754594e-06 NA NA NA hsa-miR-378a-5p SERPINE1 -0.559739196974497 0.724882066659501 0.96681951287161 0.431832134223424 MirTarget -0.554403270226226 5.62890560277356e-08 NA NA NA hsa-miR-421 SERPINE1 -0.182032017078616 0.734704500318599 0.96681951287161 0.431832134223424 miRanda -0.4187949705305 1.59873183496775e-05 NA NA NA hsa-miR-425-5p SERPINE1 -0.354606074344121 0.845979106734409 0.96681951287161 0.431832134223424 MirTarget;miRNATAP -0.539837029629402 3.22785867994715e-09 NA NA NA hsa-miR-452-3p SERPINE1 -0.167134177977311 0.799008246175244 0.96681951287161 0.431832134223424 mirMAP -0.387349978711447 4.9007015177797e-08 NA NA NA hsa-miR-514a-3p SERPINE1 0.225565546021878 0.698230923597728 0.96681951287161 0.431832134223424 MirTarget -0.136017329312072 0.00373053289515343 NA NA NA hsa-miR-590-3p SERPINE1 -0.279244755376859 0.59126669933662 0.96681951287161 0.431832134223424 miRanda -0.427705635848324 3.44299867200292e-07 NA NA NA hsa-miR-629-3p SERPINE1 -0.495402745812008 0.333967382214384 0.96681951287161 0.431832134223424 MirTarget -0.279203313822867 0.000661797194416096 NA NA NA hsa-miR-769-5p SERPINE1 -0.306614906942583 0.735704301598833 0.96681951287161 0.431832134223424 MirTarget;miRNATAP -0.599789409744915 6.57783342157547e-06 NA NA NA hsa-miR-942-5p SERPINE1 -0.50502396741886 0.50777904281306 0.96681951287161 0.431832134223424 MirTarget -0.446343175645108 7.50374419944024e-08 NA NA NA hsa-miR-146b-5p SESN1 -0.402662509440887 0.837510937985091 0.233081514361436 0.85650788259054 miRanda -0.494287415832993 4.97191204406314e-07 NA NA NA hsa-miR-15b-5p SESN1 -0.272614787130877 0.87096541832188 0.233081514361436 0.85650788259054 MirTarget;miRNATAP -0.274474033608082 0.0059011542161044 NA NA NA hsa-miR-21-5p SESN1 -0.148920887107433 0.970240620972126 0.233081514361436 0.85650788259054 miRNAWalker2_validate -0.426316288222365 0.00423772914878729 NA NA NA hsa-miR-22-3p SESN1 0.0592693913158495 0.986564295498741 0.233081514361436 0.85650788259054 MirTarget -0.692022487210637 4.4570009516396e-06 NA NA NA hsa-miR-106b-5p SESN3 -0.297128724729339 0.869294443540749 -0.0161909643475273 0.975036894001187 MirTarget -0.530972009307934 2.79273261746928e-05 NA NA NA hsa-miR-126-5p SESN3 0.0815213541035824 0.956637332055185 -0.0161909643475273 0.975036894001187 mirMAP -0.392089437702571 0.00631716723995253 NA NA NA hsa-miR-130b-3p SESN3 -0.221667315324818 0.824660172394714 -0.0161909643475273 0.975036894001187 mirMAP -0.490386963086529 1.56082640687247e-05 NA NA NA hsa-miR-144-3p SESN3 0.0482420655617901 0.935871997593533 -0.0161909643475273 0.975036894001187 mirMAP -0.224589627115245 0.000899801191014795 NA NA NA hsa-miR-146b-5p SESN3 -0.402662509440887 0.837510937985091 -0.0161909643475273 0.975036894001187 PITA;miRanda;miRNATAP -0.331647532665844 0.00906947763155007 NA NA NA hsa-miR-16-2-3p SESN3 -0.36717860153421 0.546850726070016 -0.0161909643475273 0.975036894001187 mirMAP -0.444757570943187 1.08185517170781e-05 NA NA NA hsa-miR-17-5p SESN3 -0.175448849583061 0.934544015912731 -0.0161909643475273 0.975036894001187 MirTarget;TargetScan -0.255812194593363 0.0088622714014861 NA NA NA hsa-miR-186-5p SESN3 -0.318786974828757 0.85412722938961 -0.0161909643475273 0.975036894001187 MirTarget -0.516576622918176 0.000938055989595024 NA NA NA hsa-miR-192-3p SESN3 -0.182835023264086 0.910241598161436 -0.0161909643475273 0.975036894001187 MirTarget -0.284155828224591 0.00343710542997279 NA NA NA hsa-miR-19b-1-5p SESN3 -0.0105982583216702 0.988511655226679 -0.0161909643475273 0.975036894001187 MirTarget -0.302504255163024 0.00326501567347918 NA NA NA hsa-miR-200b-5p SESN3 -0.502275384207405 0.722255155236927 -0.0161909643475273 0.975036894001187 mirMAP -0.268378741262424 0.00809523584172894 NA NA NA hsa-miR-20a-3p SESN3 0.456808229166028 0.57674056136504 -0.0161909643475273 0.975036894001187 mirMAP -0.208999194653067 0.00734292788928639 NA NA NA hsa-miR-222-5p SESN3 -0.154611068970282 0.819707762805266 -0.0161909643475273 0.975036894001187 MirTarget -0.399601044768741 3.07959441962721e-06 NA NA NA hsa-miR-25-3p SESN3 -0.457540448732733 0.878574066837636 -0.0161909643475273 0.975036894001187 MirTarget;miRNATAP -0.575770284273164 0.000222376608250099 NA NA NA hsa-miR-26b-3p SESN3 -0.363222538866814 0.681115126930068 -0.0161909643475273 0.975036894001187 MirTarget -0.417618091478911 0.000278148891547251 NA NA NA hsa-miR-29a-5p SESN3 -0.31835175571979 0.600442757817281 -0.0161909643475273 0.975036894001187 MirTarget;mirMAP -0.301556198489906 0.00304599760776391 NA NA NA hsa-miR-29b-1-5p SESN3 -0.642348119412534 0.293891497238796 -0.0161909643475273 0.975036894001187 mirMAP -0.248879530963947 0.00169046201953462 NA NA NA hsa-miR-301a-3p SESN3 -0.105312511901769 0.831686745977347 -0.0161909643475273 0.975036894001187 mirMAP -0.286507226250219 0.00310925434055328 NA NA NA hsa-miR-30d-3p SESN3 -0.123474741320298 0.814905367625791 -0.0161909643475273 0.975036894001187 mirMAP -0.32764543884289 0.00845217626606183 NA NA NA hsa-miR-32-3p SESN3 -0.568003960723004 0.13133163420273 -0.0161909643475273 0.975036894001187 mirMAP -0.396526826939468 5.42228032690503e-07 NA NA NA hsa-miR-32-5p SESN3 -0.05993267619119 0.952975951594959 -0.0161909643475273 0.975036894001187 MirTarget;miRNATAP -0.32706033276695 0.0026700669080443 NA NA NA hsa-miR-338-5p SESN3 0.484769112400393 0.393961930708873 -0.0161909643475273 0.975036894001187 mirMAP -0.212765253624106 0.00860597700811531 NA NA NA hsa-miR-33a-3p SESN3 -0.794543849238581 0.0105203072007922 -0.0161909643475273 0.975036894001187 MirTarget;mirMAP -0.353809064956217 0.00016114959144834 NA NA NA hsa-miR-33a-5p SESN3 -0.205788753603336 0.853314500865147 -0.0161909643475273 0.975036894001187 mirMAP -0.196080841045318 0.00110499327005922 NA NA NA hsa-miR-33b-5p SESN3 -0.161971614375297 0.737436207821109 -0.0161909643475273 0.975036894001187 mirMAP -0.288500973359987 1.2251724504974e-05 NA NA NA hsa-miR-340-5p SESN3 -0.00276909425328853 0.99757361161055 -0.0161909643475273 0.975036894001187 mirMAP -0.452267962242985 0.000506163818650938 NA NA NA hsa-miR-421 SESN3 -0.182032017078616 0.734704500318599 -0.0161909643475273 0.975036894001187 mirMAP -0.303686743451552 0.00446233214881383 NA NA NA hsa-miR-429 SESN3 -0.456485631615963 0.806240953400535 -0.0161909643475273 0.975036894001187 MirTarget -0.274846787324155 0.00179129645055099 NA NA NA hsa-miR-500a-5p SESN3 -0.71978560736831 0.188073776225276 -0.0161909643475273 0.975036894001187 mirMAP -0.299283755820103 0.00165801193870946 NA NA NA hsa-miR-576-5p SESN3 -0.506413219377403 0.417187951364173 -0.0161909643475273 0.975036894001187 mirMAP -0.413094366096179 0.000198093328221462 NA NA NA hsa-miR-577 SESN3 -1.06238199218774 0.326056761787754 -0.0161909643475273 0.975036894001187 mirMAP -0.22779324013097 7.40083034616389e-05 NA NA NA hsa-miR-582-5p SESN3 -0.399450205475138 0.581227478860085 -0.0161909643475273 0.975036894001187 MirTarget -0.56308586501485 2.1685400629668e-06 NA NA NA hsa-miR-589-3p SESN3 -0.835836305204965 0.0112001563801511 -0.0161909643475273 0.975036894001187 MirTarget;mirMAP -0.321312902249781 0.000191076326695886 NA NA NA hsa-miR-589-5p SESN3 -0.448771545046784 0.722725226273464 -0.0161909643475273 0.975036894001187 MirTarget -0.725716962434467 1.47385915320833e-06 NA NA NA hsa-miR-590-3p SESN3 -0.279244755376859 0.59126669933662 -0.0161909643475273 0.975036894001187 miRNAWalker2_validate;MirTarget;miRanda -0.462065496187817 4.12825165112282e-07 NA NA NA hsa-miR-625-3p SESN3 -0.977871291091597 0.62432866948939 -0.0161909643475273 0.975036894001187 mirMAP -0.367675359443485 6.2021530990782e-06 NA NA NA hsa-miR-625-5p SESN3 -0.690759472145277 0.210306534567564 -0.0161909643475273 0.975036894001187 MirTarget -0.384037137562736 1.84838211851288e-06 NA NA NA hsa-miR-7-1-3p SESN3 -0.462485777435991 0.665899751398166 -0.0161909643475273 0.975036894001187 MirTarget;mirMAP -0.544194172931168 3.57317362133861e-07 NA NA NA hsa-miR-877-5p SESN3 -0.317720731672575 0.435952264022643 -0.0161909643475273 0.975036894001187 mirMAP -0.338700469956172 2.52661954032281e-05 NA NA NA hsa-miR-142-3p SIAH1 -0.154235241441331 0.946098054588918 0.054033606017696 0.961532813193172 miRanda -0.10765334580304 3.68881036481584e-07 NA NA NA hsa-let-7a-3p THBS1 -0.215598045625677 0.85543299203799 0.37603535083018 0.836094799366458 mirMAP -0.41118832969956 1.17692621132587e-05 NA NA NA hsa-let-7d-5p THBS1 -0.139747701175051 0.934164162708487 0.37603535083018 0.836094799366458 miRNAWalker2_validate -0.719338910529418 1.28583403501255e-07 NA NA NA hsa-let-7f-1-3p THBS1 -0.31101436822914 0.693407210545374 0.37603535083018 0.836094799366458 mirMAP -0.463711142054319 0.00032640810606793 NA NA NA hsa-miR-1304-5p THBS1 -0.497887681787993 0.163079003594721 0.37603535083018 0.836094799366458 MirTarget -0.290009661016067 3.21252145412814e-06 NA NA NA hsa-miR-151a-3p THBS1 -0.0829874640636401 0.975334671097605 0.37603535083018 0.836094799366458 MirTarget -0.595363062195978 1.26067921863967e-06 NA NA NA hsa-miR-16-1-3p THBS1 0.151694812889216 0.733736501874638 0.37603535083018 0.836094799366458 MirTarget -0.331707770084304 8.70940308366408e-06 NA NA NA hsa-miR-17-5p THBS1 -0.175448849583061 0.934544015912731 0.37603535083018 0.836094799366458 miRNAWalker2_validate -0.542287170978251 2.21455240955436e-14 NA NA NA hsa-miR-182-5p THBS1 -0.104238497940557 0.973380614062243 0.37603535083018 0.836094799366458 MirTarget -0.440739082912491 1.8073484994174e-09 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 -0.318786974828757 0.85412722938961 0.37603535083018 0.836094799366458 mirMAP -0.608952798433662 2.47915506371775e-07 NA NA NA hsa-miR-18a-5p THBS1 -0.498318455303917 0.61264091975585 0.37603535083018 0.836094799366458 MirTarget -0.385312140125092 2.00045829060915e-10 NA NA NA hsa-miR-18b-5p THBS1 -0.0473300652227538 0.899981261531446 0.37603535083018 0.836094799366458 MirTarget -0.339766615395865 1.37777042193251e-08 NA NA NA hsa-miR-19a-3p THBS1 -0.206793507801887 0.844637784802316 0.37603535083018 0.836094799366458 MirTarget;mirMAP -0.393321940396923 1.51728383944411e-08 NA NA NA hsa-miR-19b-3p THBS1 -0.0268530183621474 0.986656783046572 0.37603535083018 0.836094799366458 MirTarget;mirMAP -0.500532481435115 1.42800824280983e-09 NA NA NA hsa-miR-200a-5p THBS1 -0.671005453811576 0.78126028567661 0.37603535083018 0.836094799366458 MirTarget -0.522682977399615 3.8018258765331e-12 NA NA NA hsa-miR-200b-5p THBS1 -0.502275384207405 0.722255155236927 0.37603535083018 0.836094799366458 MirTarget -0.585054033537504 1.31516173644716e-15 NA NA NA hsa-miR-20a-5p THBS1 -0.179153323927949 0.928118119139752 0.37603535083018 0.836094799366458 miRNAWalker2_validate -0.470580652824932 3.57671741010858e-11 NA NA NA hsa-miR-29b-1-5p THBS1 -0.642348119412534 0.293891497238796 0.37603535083018 0.836094799366458 mirMAP -0.369904190544962 3.6333073142916e-10 NA NA NA hsa-miR-32-5p THBS1 -0.05993267619119 0.952975951594959 0.37603535083018 0.836094799366458 mirMAP -0.488625825442418 1.82876859746085e-09 NA NA NA hsa-miR-335-3p THBS1 -0.244830745789445 0.88450019116631 0.37603535083018 0.836094799366458 mirMAP -0.400957216960711 1.65646707648448e-07 NA NA NA hsa-miR-33a-3p THBS1 -0.794543849238581 0.0105203072007922 0.37603535083018 0.836094799366458 MirTarget;mirMAP -0.229718231056134 0.0015302648509945 NA NA NA hsa-miR-375 THBS1 -0.690952835064582 0.831716365337668 0.37603535083018 0.836094799366458 miRanda -0.238796936612876 8.72515902203638e-06 NA NA NA hsa-miR-421 THBS1 -0.182032017078616 0.734704500318599 0.37603535083018 0.836094799366458 miRanda -0.366836315247693 5.97643249097868e-06 NA NA NA hsa-miR-500a-5p THBS1 -0.71978560736831 0.188073776225276 0.37603535083018 0.836094799366458 mirMAP -0.361271149320601 5.14215756637248e-07 NA NA NA hsa-miR-576-5p THBS1 -0.506413219377403 0.417187951364173 0.37603535083018 0.836094799366458 mirMAP -0.445801292946502 1.13145649504503e-07 NA NA NA hsa-miR-577 THBS1 -1.06238199218774 0.326056761787754 0.37603535083018 0.836094799366458 mirMAP -0.320712203502624 2.98965890278874e-14 NA NA NA hsa-miR-589-3p THBS1 -0.835836305204965 0.0112001563801511 0.37603535083018 0.836094799366458 mirMAP -0.244790151703082 0.00022198427277421 NA NA NA hsa-miR-590-3p THBS1 -0.279244755376859 0.59126669933662 0.37603535083018 0.836094799366458 miRanda -0.425999295779669 7.7644420709461e-10 NA NA NA hsa-miR-590-5p THBS1 -0.547819833829572 0.472735645776647 0.37603535083018 0.836094799366458 miRanda;mirMAP -0.499886795402802 5.25392011734012e-12 NA NA NA hsa-miR-629-3p THBS1 -0.495402745812008 0.333967382214384 0.37603535083018 0.836094799366458 MirTarget -0.294242028378809 1.53263223284399e-05 NA NA NA hsa-miR-671-5p THBS1 -0.373754118103105 0.411207779636977 0.37603535083018 0.836094799366458 MirTarget -0.367576368626689 2.96555063023917e-05 NA NA NA hsa-miR-7-1-3p THBS1 -0.462485777435991 0.665899751398166 0.37603535083018 0.836094799366458 MirTarget;mirMAP -0.430026468156785 1.63430969689822e-07 NA NA NA hsa-miR-92a-3p THBS1 0.0278830870766349 0.993247426671713 0.37603535083018 0.836094799366458 miRNAWalker2_validate -0.558155146051118 4.90135167178647e-11 NA NA NA hsa-miR-940 THBS1 -0.225788347550697 0.680055767105815 0.37603535083018 0.836094799366458 MirTarget -0.23198243446538 0.000141164521779727 NA NA NA hsa-miR-98-5p THBS1 -0.168162186023221 0.898802461503524 0.37603535083018 0.836094799366458 miRNAWalker2_validate -0.47060302964344 4.45298152570222e-05 NA NA NA hsa-miR-30a-5p TNFRSF10B 0.219472325612346 0.933954023293816 -0.383201678231656 0.799628854665791 miRNAWalker2_validate -0.290874641193986 0.000283561036834234 NA NA NA hsa-miR-296-5p TP73 0.457771815193432 0.288152432255385 -1.03320293702288 0.0416948309985013 mirMAP -0.216519309360074 0.00182544697699113 NA NA NA hsa-miR-335-5p TP73 -0.0284895175847679 0.973380867832231 -1.03320293702288 0.0416948309985013 mirMAP -0.263088700886482 0.00961892519512495 NA NA NA hsa-let-7a-3p ZMAT3 -0.215598045625677 0.85543299203799 -0.325283318095946 0.503935903211143 mirMAP -0.340319811934054 2.22466728931602e-06 NA NA NA hsa-let-7f-1-3p ZMAT3 -0.31101436822914 0.693407210545374 -0.325283318095946 0.503935903211143 mirMAP -0.290548412064039 0.00358581546454502 NA NA NA hsa-miR-106a-5p ZMAT3 -0.203919267842652 0.802213958426804 -0.325283318095946 0.503935903211143 mirMAP -0.269301835490528 3.22981535812791e-05 NA NA NA hsa-miR-106b-5p ZMAT3 -0.297128724729339 0.869294443540749 -0.325283318095946 0.503935903211143 mirMAP -0.517528839498258 7.79014355526204e-13 NA NA NA hsa-miR-126-5p ZMAT3 0.0815213541035824 0.956637332055185 -0.325283318095946 0.503935903211143 mirMAP -0.307212619695659 0.000273462285845791 NA NA NA hsa-miR-130a-3p ZMAT3 0.0910074087716906 0.929098200371948 -0.325283318095946 0.503935903211143 MirTarget -0.208876190142419 0.00217860835244575 NA NA NA hsa-miR-130b-3p ZMAT3 -0.221667315324818 0.824660172394714 -0.325283318095946 0.503935903211143 MirTarget -0.398601946420125 1.41409850423191e-09 NA NA NA hsa-miR-148a-3p ZMAT3 -0.101286586375016 0.976980454193186 -0.325283318095946 0.503935903211143 MirTarget -0.219553063061511 0.00116871744467873 NA NA NA hsa-miR-148b-5p ZMAT3 -0.236618793990305 0.43925706879726 -0.325283318095946 0.503935903211143 MirTarget -0.252396942933299 2.34825147760321e-05 NA NA NA hsa-miR-15a-5p ZMAT3 -0.0674049094129128 0.964835434214123 -0.325283318095946 0.503935903211143 MirTarget -0.332297503873563 2.38818010074891e-05 NA NA NA hsa-miR-15b-3p ZMAT3 -0.557749208157585 0.609181305423188 -0.325283318095946 0.503935903211143 mirMAP -0.317841839118737 1.96500686627198e-06 NA NA NA hsa-miR-15b-5p ZMAT3 -0.272614787130877 0.87096541832188 -0.325283318095946 0.503935903211143 MirTarget -0.26256698279685 0.000407895791162403 NA NA NA hsa-miR-16-5p ZMAT3 0.0135949734723564 0.994476223855607 -0.325283318095946 0.503935903211143 MirTarget -0.396845149044195 4.649567809806e-08 NA NA NA hsa-miR-17-5p ZMAT3 -0.175448849583061 0.934544015912731 -0.325283318095946 0.503935903211143 mirMAP -0.285186188627848 4.79322019781295e-07 NA NA NA hsa-miR-186-5p ZMAT3 -0.318786974828757 0.85412722938961 -0.325283318095946 0.503935903211143 MirTarget -0.273075257221368 0.00320275043367972 NA NA NA hsa-miR-18a-3p ZMAT3 -0.270443061178857 0.535291623032886 -0.325283318095946 0.503935903211143 MirTarget -0.197894496636808 3.08561044641327e-05 NA NA NA hsa-miR-192-5p ZMAT3 -0.117345487848223 0.972927287653137 -0.325283318095946 0.503935903211143 miRNAWalker2_validate;MirTarget -0.195215339792154 0.000168934970033073 NA NA NA hsa-miR-193a-3p ZMAT3 -0.247265785363732 0.654363581941634 -0.325283318095946 0.503935903211143 MirTarget -0.224687683704772 0.000264691379373392 NA NA NA hsa-miR-193b-3p ZMAT3 0.0672068426635715 0.951480422273678 -0.325283318095946 0.503935903211143 MirTarget -0.174451225569246 0.00451887148169876 NA NA NA hsa-miR-19a-3p ZMAT3 -0.206793507801887 0.844637784802316 -0.325283318095946 0.503935903211143 MirTarget -0.283687825934435 1.27385785677516e-07 NA NA NA hsa-miR-19b-3p ZMAT3 -0.0268530183621474 0.986656783046572 -0.325283318095946 0.503935903211143 MirTarget -0.314837503478028 1.06717457283946e-06 NA NA NA hsa-miR-20a-5p ZMAT3 -0.179153323927949 0.928118119139752 -0.325283318095946 0.503935903211143 mirMAP -0.240040244786558 1.98473507762e-05 NA NA NA hsa-miR-22-5p ZMAT3 -0.0785922550675187 0.93169760098231 -0.325283318095946 0.503935903211143 mirMAP -0.233182277201073 0.000234103201888079 NA NA NA hsa-miR-27a-3p ZMAT3 -0.123902317731458 0.958804393510999 -0.325283318095946 0.503935903211143 MirTarget;miRNATAP -0.356189373028324 0.000716559401231237 NA NA NA hsa-miR-29b-1-5p ZMAT3 -0.642348119412534 0.293891497238796 -0.325283318095946 0.503935903211143 mirMAP -0.171091881411953 0.000250411959356552 NA NA NA hsa-miR-301a-3p ZMAT3 -0.105312511901769 0.831686745977347 -0.325283318095946 0.503935903211143 MirTarget -0.201219251875654 0.000426085923021998 NA NA NA hsa-miR-32-3p ZMAT3 -0.568003960723004 0.13133163420273 -0.325283318095946 0.503935903211143 mirMAP -0.236966451144809 4.13568227988992e-07 NA NA NA hsa-miR-33a-3p ZMAT3 -0.794543849238581 0.0105203072007922 -0.325283318095946 0.503935903211143 mirMAP -0.150546421152039 0.00711637969389338 NA NA NA hsa-miR-362-3p ZMAT3 -0.721040238345347 0.0345881362485733 -0.325283318095946 0.503935903211143 MirTarget -0.292037657898756 2.37510751848372e-08 NA NA NA hsa-miR-362-5p ZMAT3 -0.26647467080141 0.752024885130738 -0.325283318095946 0.503935903211143 mirMAP -0.292287022915692 3.55640579342169e-09 NA NA NA hsa-miR-369-3p ZMAT3 0.116576891957687 0.83230082995912 -0.325283318095946 0.503935903211143 mirMAP -0.280336537877248 2.7674636603168e-05 NA NA NA hsa-miR-374a-3p ZMAT3 -0.118320910531011 0.958176637009264 -0.325283318095946 0.503935903211143 MirTarget;miRNATAP -0.235092538874321 0.000342719354267392 NA NA NA hsa-miR-374a-5p ZMAT3 -0.343007247142618 0.766921280269271 -0.325283318095946 0.503935903211143 mirMAP -0.446182282904888 1.55287698039036e-06 NA NA NA hsa-miR-374b-5p ZMAT3 -0.285682091626878 0.83569830479965 -0.325283318095946 0.503935903211143 mirMAP -0.477463071563325 9.5500762834284e-08 NA NA NA hsa-miR-421 ZMAT3 -0.182032017078616 0.734704500318599 -0.325283318095946 0.503935903211143 mirMAP;miRNATAP -0.274734757268515 1.07014426536972e-05 NA NA NA hsa-miR-424-5p ZMAT3 0.247080963500746 0.870154571783568 -0.325283318095946 0.503935903211143 MirTarget -0.235208480745054 1.60469767707012e-05 NA NA NA hsa-miR-425-5p ZMAT3 -0.354606074344121 0.845979106734409 -0.325283318095946 0.503935903211143 MirTarget -0.271424474292441 5.32072386787997e-06 NA NA NA hsa-miR-429 ZMAT3 -0.456485631615963 0.806240953400535 -0.325283318095946 0.503935903211143 MirTarget;miRNATAP -0.210577171032804 4.61772532642581e-05 NA NA NA hsa-miR-452-5p ZMAT3 -0.0504626418153507 0.973874641360401 -0.325283318095946 0.503935903211143 MirTarget;mirMAP -0.250204332020823 7.0827105851476e-05 NA NA NA hsa-miR-454-3p ZMAT3 -0.101514866328011 0.843545158256191 -0.325283318095946 0.503935903211143 MirTarget -0.345545894196049 9.06267999853756e-06 NA NA NA hsa-miR-501-5p ZMAT3 -0.834032628506285 0.0582725160418523 -0.325283318095946 0.503935903211143 MirTarget;mirMAP -0.193628600724202 6.83883323899516e-05 NA NA NA hsa-miR-550a-3p ZMAT3 -0.6199901113685 0.0836206511566976 -0.325283318095946 0.503935903211143 mirMAP -0.199378030719258 0.000267781961096038 NA NA NA hsa-miR-576-5p ZMAT3 -0.506413219377403 0.417187951364173 -0.325283318095946 0.503935903211143 MirTarget -0.220188676355536 0.000833336514990389 NA NA NA hsa-miR-577 ZMAT3 -1.06238199218774 0.326056761787754 -0.325283318095946 0.503935903211143 MirTarget;mirMAP;miRNATAP -0.107674418617055 0.00166429416766914 NA NA NA hsa-miR-590-3p ZMAT3 -0.279244755376859 0.59126669933662 -0.325283318095946 0.503935903211143 mirMAP;miRNATAP -0.298575411270305 2.686982908743e-08 NA NA NA hsa-miR-590-5p ZMAT3 -0.547819833829572 0.472735645776647 -0.325283318095946 0.503935903211143 miRanda -0.376591231252673 1.57822646739763e-11 NA NA NA hsa-miR-660-5p ZMAT3 -0.476129334484339 0.694082832658925 -0.325283318095946 0.503935903211143 mirMAP -0.298026095853651 8.60255989985654e-06 NA NA NA hsa-miR-671-5p ZMAT3 -0.373754118103105 0.411207779636977 -0.325283318095946 0.503935903211143 MirTarget -0.256387964846985 0.000161116577019596 NA NA NA hsa-miR-7-5p ZMAT3 0.209645143210379 0.773705612298441 -0.325283318095946 0.503935903211143 MirTarget -0.233339338608314 5.88587794193318e-09 NA NA NA hsa-miR-93-5p ZMAT3 -0.611073677204699 0.825297877093193 -0.325283318095946 0.503935903211143 mirMAP -0.277110992402198 9.64802217742588e-05 NA NA NA hsa-miR-940 ZMAT3 -0.225788347550697 0.680055767105815 -0.325283318095946 0.503935903211143 MirTarget;miRNATAP -0.233408503115004 4.64714955106832e-07 NA NA NA hsa-miR-942-5p ZMAT3 -0.50502396741886 0.50777904281306 -0.325283318095946 0.503935903211143 MirTarget -0.210519623085215 0.000103848577100616 NA NA NA