miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-122-5p ADAM17 -1.23907441373955 4.42181244888642e-06 0.0812315981028044 0.572253270349355 miRNAWalker2_validate;miRTarBase -0.194925453792799 3.69477572804222e-15 19296470 We further showed that one of the miR-122 targets ADAM17 a disintegrin and metalloprotease 17 is involved in metastasis; Silencing of ADAM17 resulted in a dramatic reduction of in vitro migration invasion in vivo tumorigenesis angiogenesis and local invasion in the livers of nude mice which is similar to that which occurs with the restoration of miR-122; Our study suggests that miR-122 a tumor suppressor microRNA affecting hepatocellular carcinoma intrahepatic metastasis by angiogenesis suppression exerts some of its action via regulation of ADAM17; Using the concomitant down-regulation of its targets including ADAM17 a rational therapeutic strategy based on miR-122 may prove to be beneficial for patients with hepatocellular carcinoma metastasis;tumorigenesis liver cancer hsa-miR-145-5p APH1A -1.4795885711477 6.47308361543414e-16 0.326774606842128 7.1443884106445e-06 miRNAWalker2_validate -0.104983163859547 1.37106129803436e-08 NA NA NA hsa-miR-1976 APH1A -0.431472440543166 0.00324575010550946 0.326774606842128 7.1443884106445e-06 MirTarget -0.130592679222568 5.12922997648964e-08 NA NA NA hsa-miR-2355-5p APH1A -0.233446678887995 0.157909851771338 0.326774606842128 7.1443884106445e-06 MirTarget -0.103809662672675 1.21978082908915e-06 NA NA NA hsa-miR-342-3p APH1A -0.319677314984262 0.0449813878317147 0.326774606842128 7.1443884106445e-06 miRanda -0.126260799339623 1.01147998512957e-08 NA NA NA hsa-miR-582-5p APH1A -0.680189083316822 0.00103755166534107 0.326774606842128 7.1443884106445e-06 PITA -0.123648890551193 1.28426530559178e-13 NA NA NA hsa-miR-324-3p CREBBP 0.260348469146494 0.0506141704203545 -0.198953226514463 0.0138678371438249 miRNAWalker2_validate -0.122219674872295 3.31240083157391e-05 NA NA NA hsa-miR-330-5p CREBBP 0.442231058604099 0.0053308560843808 -0.198953226514463 0.0138678371438249 miRanda -0.10760918491025 1.18364633640293e-05 NA NA NA hsa-miR-769-5p CREBBP 0.219661452072771 0.0333425465750576 -0.198953226514463 0.0138678371438249 miRNAWalker2_validate -0.128844707446474 0.00077006671697313 NA NA NA hsa-miR-146b-5p CTBP2 0.419719546795449 0.0457375823220155 -0.39317918949034 0.0225071278697855 miRanda -0.176036756804994 9.21105923068651e-06 NA NA NA hsa-miR-616-5p CTBP2 0.150569904638223 0.402836556304524 -0.39317918949034 0.0225071278697855 mirMAP -0.312610374730466 9.41444908463415e-12 NA NA NA hsa-miR-618 CTBP2 0.13539895350352 0.517145913114103 -0.39317918949034 0.0225071278697855 MirTarget;PITA -0.334800818337328 8.46589457931172e-17 NA NA NA hsa-miR-103a-3p DLL1 0.765568928457606 3.05497476509383e-12 -0.548830846531552 0.0160272291862025 miRNATAP -0.513614513410521 1.73587390060657e-07 NA NA NA hsa-miR-107 DLL1 0.241662461253461 0.0170788899505389 -0.548830846531552 0.0160272291862025 PITA;miRanda;miRNATAP -0.624807569648453 1.02631649549249e-08 NA NA NA hsa-miR-130b-3p DLL1 0.687190305027546 0.000109068658562255 -0.548830846531552 0.0160272291862025 miRNATAP -0.207363383696206 0.000847295054218825 NA NA NA hsa-miR-146b-5p DLL1 0.419719546795449 0.0457375823220155 -0.548830846531552 0.0160272291862025 miRanda -0.175688247040319 0.000878870145815347 NA NA NA hsa-miR-15a-5p DLL1 0.349521211668244 0.000770735998804736 -0.548830846531552 0.0160272291862025 miRNATAP -0.367212146758552 0.000619658629327403 NA NA NA hsa-miR-15b-5p DLL1 0.230566941413564 0.0824765001857479 -0.548830846531552 0.0160272291862025 miRNATAP -0.348164862027142 3.18330755592305e-05 NA NA NA hsa-miR-301a-3p DLL1 0.842910511640361 1.43446467417891e-06 -0.548830846531552 0.0160272291862025 miRNATAP -0.258185613691722 3.70622789079857e-05 NA NA NA hsa-miR-423-3p DLL1 0.302157659154355 0.000669907339064765 -0.548830846531552 0.0160272291862025 PITA -0.608381370585496 1.18042502673822e-06 NA NA NA hsa-miR-454-3p DLL1 0.668749059573955 2.42670710515113e-06 -0.548830846531552 0.0160272291862025 miRNATAP -0.207582215687797 0.00765702270398649 NA NA NA hsa-miR-589-5p DLL1 1.18593770505086 1.01781241960531e-22 -0.548830846531552 0.0160272291862025 miRNATAP -0.633239756642235 1.06441461099555e-13 NA NA NA hsa-miR-29a-5p DLL4 -0.113555908626946 0.349622266470788 1.07379585219093 2.85322047024912e-15 miRNATAP -0.213977542207208 0.000159054923679029 NA NA NA hsa-miR-30c-5p DLL4 -0.432111642767632 0.000159764714931007 1.07379585219093 2.85322047024912e-15 miRNATAP -0.174410218216806 0.003592820944387 NA NA NA hsa-miR-424-5p DLL4 -2.62653257498508 2.38997974737991e-50 1.07379585219093 2.85322047024912e-15 miRNATAP -0.12760985044512 0.000195990057682133 NA NA NA hsa-miR-188-5p DTX1 1.11646899351496 9.56686958408598e-11 -2.80330867157346 1.11467029801876e-16 PITA -0.322830889472767 0.000904887310557903 NA NA NA hsa-miR-421 DTX1 0.941856334694081 6.12167297054077e-08 -2.80330867157346 1.11467029801876e-16 PITA;miRanda;miRNATAP -0.353753978603264 0.000272276767697886 NA NA NA hsa-let-7a-5p DTX2 -0.328069937201898 0.000464344093744051 0.389172276410069 4.17637328390514e-06 TargetScan;miRNATAP -0.232954789846634 1.21652641686096e-07 NA NA NA hsa-let-7b-5p DTX2 -0.959013717270803 5.95127281258643e-11 0.389172276410069 4.17637328390514e-06 miRNATAP -0.119340242909356 1.47736989684342e-05 NA NA NA hsa-let-7g-5p DTX2 -0.461294133285527 2.17210114729901e-05 0.389172276410069 4.17637328390514e-06 miRNATAP -0.203888708255469 6.21851621837624e-08 NA NA NA hsa-miR-107 DTX3 0.241662461253461 0.0170788899505389 0.0814741725691028 0.674125374025254 miRanda -0.293900908901469 0.0017098584863442 NA NA NA hsa-miR-148a-5p DTX3 -0.767626696027761 1.08359477494797e-06 0.0814741725691028 0.674125374025254 mirMAP -0.351059453543964 1.68854367559999e-09 NA NA NA hsa-miR-339-5p DTX3L 0.280589919878422 0.0355660282647215 -0.189304718971913 0.0221574409286706 miRanda -0.100218518696038 0.00089022620988631 NA NA NA hsa-miR-340-3p DTX3L -0.329393899588902 0.00329627776838916 -0.189304718971913 0.0221574409286706 MirTarget -0.107116956750092 0.00291797492965776 NA NA NA hsa-miR-140-3p DTX4 0.546012239205329 4.84578261098777e-11 -0.319800932332473 0.162707708080826 miRNATAP -0.434607443807307 0.00109602515683441 NA NA NA hsa-miR-204-5p DTX4 -0.537962150012103 0.0330895493358849 -0.319800932332473 0.162707708080826 miRNATAP -0.291482289385449 1.48824481425392e-11 NA NA NA hsa-miR-29a-5p DTX4 -0.113555908626946 0.349622266470788 -0.319800932332473 0.162707708080826 mirMAP -0.457420576918009 5.99812092255147e-07 NA NA NA hsa-miR-29b-3p DTX4 -0.348885528720517 0.0121441341291285 -0.319800932332473 0.162707708080826 miRNATAP -0.26207595559829 0.00108691313657373 NA NA NA hsa-miR-374a-5p DTX4 0.016390363747302 0.869784217438621 -0.319800932332473 0.162707708080826 mirMAP -0.79608985941061 4.68812615863176e-13 NA NA NA hsa-miR-374b-5p DTX4 -0.307538028546424 0.0030079617545972 -0.319800932332473 0.162707708080826 mirMAP -0.619328346804244 6.34331594875284e-09 NA NA NA hsa-miR-548b-3p DTX4 -0.0203576084717134 0.930819503166956 -0.319800932332473 0.162707708080826 PITA;mirMAP;miRNATAP -0.18802228860786 9.18181230304614e-05 NA NA NA hsa-miR-10a-5p DVL1 -1.47723516092033 7.27299669108673e-16 0.0974490868963773 0.351327376305342 miRNAWalker2_validate -0.122692252559585 3.72861974540746e-06 NA NA NA hsa-miR-27a-3p DVL2 -0.370807380415112 0.00875721956202713 0.932937814675565 4.78146420278758e-20 miRNATAP -0.102448960625914 0.00526923611599277 NA NA NA hsa-miR-27b-3p DVL2 -0.823491817819754 9.20935302746823e-14 0.932937814675565 4.78146420278758e-20 miRNATAP -0.221394297021235 1.09073127725023e-06 NA NA NA hsa-miR-125b-5p DVL3 -1.35767721102906 1.16564617395164e-18 0.609321698955873 3.59083763972193e-15 miRNATAP -0.128110031624996 8.52754629911134e-08 NA NA NA hsa-miR-26b-5p DVL3 -1.10804856399744 4.14176110314282e-22 0.609321698955873 3.59083763972193e-15 miRNAWalker2_validate -0.111951369829111 0.000527706771327525 NA NA NA hsa-miR-29b-2-5p DVL3 -0.223258653034772 0.084306146519938 0.609321698955873 3.59083763972193e-15 MirTarget -0.104468815670416 0.000526336007952701 NA NA NA hsa-miR-339-5p EP300 0.280589919878422 0.0355660282647215 -0.200382966790078 0.0704945874784134 miRanda -0.157358640254018 9.53193539159902e-05 NA NA NA hsa-miR-342-3p EP300 -0.319677314984262 0.0449813878317147 -0.200382966790078 0.0704945874784134 MirTarget;PITA;miRanda;miRNATAP -0.112632997815777 0.000853079257159957 NA NA NA hsa-miR-30a-5p HDAC1 -0.626257932887855 0.000108198196973765 0.310222809591839 0.000149745117698607 miRNAWalker2_validate -0.146313546021308 1.38072373678855e-09 NA NA NA hsa-let-7b-3p HDAC2 -1.21979213547786 5.84575581584603e-17 0.159768613336722 0.0632725636896593 mirMAP -0.122366992013411 8.0964121762738e-06 NA NA NA hsa-miR-125b-2-3p HDAC2 -1.6609436107315 5.71534047969855e-18 0.159768613336722 0.0632725636896593 mirMAP -0.102822311849734 6.33678598956499e-07 NA NA NA hsa-miR-16-1-3p JAG1 0.392360028038559 0.00112481918108198 0.284179809900906 0.0962289282729052 MirTarget -0.25864801952296 0.000175217874136401 NA NA NA hsa-miR-186-5p JAG1 -0.060103391373687 0.535288717081205 0.284179809900906 0.0962289282729052 MirTarget;miRNATAP -0.299717311456832 0.000549675971863329 NA NA NA hsa-miR-26b-3p JAG1 -1.25503731613309 4.45390890119649e-27 0.284179809900906 0.0962289282729052 miRNATAP -0.271142455365564 5.11847934567858e-05 NA NA NA hsa-miR-26b-5p JAG1 -1.10804856399744 4.14176110314282e-22 0.284179809900906 0.0962289282729052 MirTarget;miRNATAP -0.204674480756369 0.00312568843049826 NA NA NA hsa-miR-34a-5p JAG1 1.03694231790865 5.74864019540594e-14 0.284179809900906 0.0962289282729052 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.193173900876987 0.000964941592670474 NA NA NA hsa-miR-361-3p JAG1 0.275658012727111 0.00549374744374488 0.284179809900906 0.0962289282729052 miRNATAP -0.235399843390808 0.00532784841352524 NA NA NA hsa-miR-590-5p JAG1 -0.103355559980404 0.310027295317092 0.284179809900906 0.0962289282729052 MirTarget;PITA;miRanda;miRNATAP -0.308680542890841 0.000177826911226686 NA NA NA hsa-miR-140-5p JAG2 -0.220106443070144 0.0140713197101242 1.63935349038013 5.44903322246813e-19 miRanda -0.369236440158915 0.000475964711091949 NA NA NA hsa-miR-3607-3p JAG2 -2.15518588554493 1.03390728226728e-23 1.63935349038013 5.44903322246813e-19 miRNATAP -0.236898029698969 5.5004048106838e-09 NA NA NA hsa-miR-505-3p JAG2 -1.20027021591555 1.27927500175937e-13 1.63935349038013 5.44903322246813e-19 mirMAP -0.326536073466515 3.70410554850449e-09 NA NA NA hsa-miR-342-3p KAT2A -0.319677314984262 0.0449813878317147 1.45977645209537 2.41711982967008e-35 MirTarget;miRanda -0.117874939654155 0.00264845581699324 NA NA NA hsa-miR-106a-5p KAT2B -0.464229535269236 0.009724944358047 -0.938558773689222 1.89276182546283e-10 MirTarget -0.177974942037781 1.1260418377257e-05 NA NA NA hsa-miR-106b-5p KAT2B 0.648901865047099 8.24870862047885e-09 -0.938558773689222 1.89276182546283e-10 miRNAWalker2_validate;miRTarBase;MirTarget -0.516609867095764 9.70587347026615e-17 NA NA NA hsa-miR-125a-3p KAT2B -0.841683158494395 3.51202687176603e-05 -0.938558773689222 1.89276182546283e-10 miRanda -0.149961442868622 3.79098733559111e-05 NA NA NA hsa-miR-17-5p KAT2B 0.698861147045461 2.43854106455398e-05 -0.938558773689222 1.89276182546283e-10 MirTarget;TargetScan -0.397123391532735 2.6874226483349e-21 23095762 miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of PCAF by miR-17-5p was evaluated using the luciferase reporter assay; Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; PCAF is upregulated in cultured PCa cells and upregulation of PCAF is associated with the downregulation of miR-17-5p; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells prostate cancer hsa-miR-181a-5p KAT2B 0.250113435902954 0.0551933249319293 -0.938558773689222 1.89276182546283e-10 miRNAWalker2_validate;miRTarBase;MirTarget -0.426890206635934 6.26669869314588e-15 NA NA NA hsa-miR-181b-5p KAT2B 0.488256489401108 0.00105321129419701 -0.938558773689222 1.89276182546283e-10 miRNAWalker2_validate;miRTarBase;MirTarget -0.457990357788594 9.28981291080347e-23 NA NA NA hsa-miR-181c-5p KAT2B -0.00639394152050299 0.969127212255928 -0.938558773689222 1.89276182546283e-10 MirTarget -0.266357788878104 1.18828300159497e-09 NA NA NA hsa-miR-181d-5p KAT2B 0.161600964883517 0.363806828762999 -0.938558773689222 1.89276182546283e-10 MirTarget -0.281403375774208 3.01108563113213e-12 NA NA NA hsa-miR-19a-3p KAT2B 1.01712596153672 2.57753201450625e-07 -0.938558773689222 1.89276182546283e-10 miRNAWalker2_validate -0.258008787485568 4.91547864954381e-13 NA NA NA hsa-miR-19b-3p KAT2B 0.601279551368824 0.00016685097085251 -0.938558773689222 1.89276182546283e-10 miRNAWalker2_validate -0.300580910813304 1.79295987685863e-11 NA NA NA hsa-miR-20a-3p KAT2B -0.318177901603857 0.0467885456739855 -0.938558773689222 1.89276182546283e-10 MirTarget -0.22387415848094 8.7626611878482e-07 NA NA NA hsa-miR-20a-5p KAT2B 0.854326758727003 5.04256669663285e-07 -0.938558773689222 1.89276182546283e-10 MirTarget -0.323298461721723 5.05244582669315e-15 NA NA NA hsa-miR-20b-5p KAT2B 0.457668023910379 0.0285865211936156 -0.938558773689222 1.89276182546283e-10 MirTarget -0.113158413426819 0.00122118573242313 NA NA NA hsa-miR-25-3p KAT2B 0.633062563556379 3.68686354834328e-10 -0.938558773689222 1.89276182546283e-10 miRNAWalker2_validate;miRTarBase;MirTarget -0.26315834694088 0.000234459458633812 NA NA NA hsa-miR-330-3p KAT2B -0.332364259424489 0.0316051913061459 -0.938558773689222 1.89276182546283e-10 MirTarget -0.273076621148565 1.18029885690117e-08 NA NA NA hsa-miR-338-5p KAT2B -0.221898432884726 0.252390988727086 -0.938558773689222 1.89276182546283e-10 MirTarget;miRNATAP -0.150468534557013 7.23998844367366e-05 NA NA NA hsa-miR-342-3p KAT2B -0.319677314984262 0.0449813878317147 -0.938558773689222 1.89276182546283e-10 miRanda -0.182145473520516 7.12764210940437e-05 NA NA NA hsa-miR-363-3p KAT2B -0.173737427255147 0.375186188765181 -0.938558773689222 1.89276182546283e-10 MirTarget -0.10241917641335 0.00632876905612432 NA NA NA hsa-miR-429 KAT2B -1.40262535827285 6.93982219171912e-05 -0.938558773689222 1.89276182546283e-10 miRanda -0.126975505385946 5.96195481912027e-10 NA NA NA hsa-miR-590-5p KAT2B -0.103355559980404 0.310027295317092 -0.938558773689222 1.89276182546283e-10 miRanda -0.257419834100684 0.000396387524632938 NA NA NA hsa-miR-92a-3p KAT2B 0.212391012518195 0.134292268089997 -0.938558773689222 1.89276182546283e-10 miRNAWalker2_validate;MirTarget -0.347457157937997 7.47334920381898e-12 NA NA NA hsa-miR-92b-3p KAT2B 0.220374930803974 0.296187538889092 -0.938558773689222 1.89276182546283e-10 MirTarget -0.225978769790196 3.27927891292608e-11 NA NA NA hsa-miR-93-5p KAT2B 1.39518349670953 2.84167728726712e-25 -0.938558773689222 1.89276182546283e-10 miRNAWalker2_validate;miRTarBase;MirTarget -0.378141581227996 4.36815875562486e-14 NA NA NA hsa-miR-107 LFNG 0.241662461253461 0.0170788899505389 0.263237340884778 0.140168628016056 miRanda -0.358835051243939 3.01060855803723e-05 NA NA NA hsa-miR-365a-3p LFNG 0.164591326307714 0.15325084963213 0.263237340884778 0.140168628016056 mirMAP -0.450007777059662 1.69813517060278e-09 NA NA NA hsa-miR-219a-5p MFNG 0.17600389823009 0.322694100196276 -0.413020228579263 0.00140029415130185 MirTarget -0.138272536986089 0.000117116928126542 NA NA NA hsa-miR-28-5p MFNG -0.430964830599964 2.67367257252925e-06 -0.413020228579263 0.00140029415130185 miRanda -0.247210505182092 0.000322085864242091 NA NA NA hsa-miR-29a-3p NCOR2 -0.856762511178136 4.65330336378459e-12 0.534673791894968 2.12570475503387e-10 miRNATAP -0.14967828357666 4.86491747621956e-06 NA NA NA hsa-miR-29b-3p NCOR2 -0.348885528720517 0.0121441341291285 0.534673791894968 2.12570475503387e-10 miRNATAP -0.133044806035329 8.35898121735485e-06 NA NA NA hsa-miR-29c-3p NCOR2 -1.4367517608807 1.61767774905781e-21 0.534673791894968 2.12570475503387e-10 miRNATAP -0.156976806568187 1.39279933464e-09 NA NA NA hsa-miR-3607-3p NCOR2 -2.15518588554493 1.03390728226728e-23 0.534673791894968 2.12570475503387e-10 miRNATAP -0.14388760189026 5.14277401033427e-16 NA NA NA hsa-miR-101-3p NOTCH1 -1.48176407980989 3.98950707385704e-31 -0.0333826274090256 0.795560724559869 MirTarget -0.125967613612003 0.00574754801726533 NA NA NA hsa-miR-34a-5p NOTCH1 1.03694231790865 5.74864019540594e-14 -0.0333826274090256 0.795560724559869 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.239301431096606 3.83055699888448e-08 22438124;23140286;24349627;24565525;25783790;20351093;27082152;23642368;22347519;23430952;23902763;21743299;22992310;23145211;25623761;23085450 Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells; In our study using miRNA microarray we observed that downregulation of the Notch-1 pathway by delta-tocotrienol correlated with upregulation of miR-34a in nonsmall cell lung cancer cells NSCLC;We found that Re-expression forced expression of miR-34a inhibits cell growth and induces apoptosis with concomitant down-regulation of Notch-1 signaling pathway one of the target of miR-34a; Moreover treatment of PC cells with a natural compound genistein led to the up-regulation of miR-34a resulting in the down-regulation of Notch-1 which was correlated with inhibition of cell growth and induction of apoptosis;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed reexpression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;In addition intracellular restoration of miR-34a inhibited breast cancer cell migration via targeting Notch-1 signaling;MicroRNA 34a suppresses the breast cancer stem cell like characteristics by downregulating Notch1 pathway; In this study we verified that miR-34a directly and functionally targeted Notch1 in MCF-7 cells; We reported that miR-34a negatively regulated cell proliferation migration and invasion and breast cancer stem cell propagation by downregulating Notch1; The expression of miR-34a was negatively correlated with tumor stages metastasis and Notch1 expression in breast cancer tissues; Furthermore overexpression of miR-34a increased chemosensitivity of breast cancer cells to paclitaxel PTX by downregulating the Notch1 pathway; Taken together our results indicate that miR-34a inhibited breast cancer stemness and increased the chemosensitivity to PTX partially by downregulating the Notch1 pathway suggesting that miR-34a/Notch1 play an important role in regulating breast cancer stem cells;MicroRNA 34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells; Computational miRNA target prediction suggested that Notch1 and Jagged1 were targets of miR-34a; By using functional assays miR-34a was demonstrated to bind to the 3' untranslated regions of Notch1 and Jagged1; Forced expression of miR-34a altered the expression of Notch1 and Jagged1 protein as well as Notch signaling as shown by the response of Hairy Enhancer of Split-1 protein to these treatments using western blot analysis;We showed that miR-34a as a tumor suppressor could separately reduce the stemness of BCSCs and activate the cytotoxic susceptibility of BCSCs to natural killer NK cells in vitro via down regulating the expression of Notch1 signaling molecules;Mechanistically miR-34a sequesters Notch1 mRNA to generate a sharp threshold response where a bimodal Notch signal specifies the choice between self-renewal and differentiation;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed re-expression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis;Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial mesenchymal transition EMT by miR 34a mediated suppression of Notch 1 expression in non small cell lung cancer cell lines; Indeed rhamnetin and cirsiliol increased the expression of tumor-suppressive microRNA miR-34a in a p53-dependent manner leading to inhibition of Notch-1 expression;MicroRNA 34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme; Also we identified notch1 as a direct target gene of miR-34a; Knockdown of notch1 showed similar cellular functions as overexpression of miR-34a both in vitro and in vivo; Collectively our findings show that miR-34a is downregulated in GBM cells and inhibits GBM growth by targeting notch1;The re-expression of miR-34 led to a marked reduction in the expression of its target gene Notch-1;Inactivation of AR and Notch 1 signaling by miR 34a attenuates prostate cancer aggressiveness; We found that over-expression of miR-34a led to reduced expression of AR PSA and Notch-1; These findings suggest that the loss of miR-34a is directly linked with up-regulation of AR and Notch-1 both of which are highly expressed in PCa and thus finding innovative approaches by which miR-34a expression could be up-regulated will have a huge impact on the treatment of PCa especially for the treatment of mCRPC;miR 34a may regulate sensitivity of breast cancer cells to adriamycin via targeting Notch1; To explore the influence of miR-34a on Notch1 expression in breast cancer cells and to explore the role of miR-34a in the sensitivity of breast cancer cells to Adriamycin ADR; The expression levels of Notch1 mRNA and protein in MCF-7/ADR cells transfected with miR-34a mimics were significantly up-regulated; On the contrary the expressions of Notch1 mRNA and protein in MCF-7 cells transfected with miR-34a inhibitor were down-regulated; miR-34a negatively regulates the expression of Notch1 at both mRNA and protein levels;MicroRNA 34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting Notch1; The association of miR-34a and Notch1 was analyzed by dual-luciferase reporter assay and Notch1-siRNA technology; Real-time PCR assay was performed to test the expression of miR-34a and Notch1 in 38 selective breast cancer tissue samples; MiR-34a mimic could inhibit the luciferase activity of the construct containing wild-type 3' UTR of Notch1 in MCF-7/ADR cells; Further there was an inverse association between Notch1 and miR-34a expression in breast cancer; Dysregulation of miR-34a plays critical roles in the acquired ADR resistance of breast cancer at least in part via targeting Notch1 ;;;cell migration;staging;metastasis;drug resistance;;differentiation;drug resistance;;;;;;;;drug resistance lung squamous cell cancer;pancreatic cancer;prostate cancer;breast cancer;breast cancer;cervical and endocervical cancer;breast cancer;colon cancer;prostate cancer;sarcoma;lung squamous cell cancer;glioblastoma;colon cancer;prostate cancer;breast cancer;breast cancer hsa-miR-103a-3p NOTCH2 0.765568928457606 3.05497476509383e-12 -0.382079512558875 0.00411077346024402 MirTarget -0.200140216686413 0.000554161926768542 NA NA NA hsa-miR-107 NOTCH2 0.241662461253461 0.0170788899505389 -0.382079512558875 0.00411077346024402 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.212584678659513 0.000997936326855663 NA NA NA hsa-miR-146b-5p NOTCH2 0.419719546795449 0.0457375823220155 -0.382079512558875 0.00411077346024402 miRanda -0.13767547742131 7.26853497786302e-06 NA NA NA hsa-miR-148a-5p NOTCH2 -0.767626696027761 1.08359477494797e-06 -0.382079512558875 0.00411077346024402 MirTarget -0.124169741301974 0.0023627624116557 NA NA NA hsa-miR-15a-5p NOTCH2 0.349521211668244 0.000770735998804736 -0.382079512558875 0.00411077346024402 MirTarget -0.211011609000242 0.000764396919128515 NA NA NA hsa-miR-16-1-3p NOTCH2 0.392360028038559 0.00112481918108198 -0.382079512558875 0.00411077346024402 mirMAP -0.165851721677464 0.00213283435133142 NA NA NA hsa-miR-17-5p NOTCH2 0.698861147045461 2.43854106455398e-05 -0.382079512558875 0.00411077346024402 miRNAWalker2_validate -0.105084570695141 0.00703883528774371 NA NA NA hsa-miR-29b-3p NOTCH2 -0.348885528720517 0.0121441341291285 -0.382079512558875 0.00411077346024402 MirTarget -0.174961937874285 0.000176008140506499 NA NA NA hsa-miR-34a-5p NOTCH2 1.03694231790865 5.74864019540594e-14 -0.382079512558875 0.00411077346024402 miRNAWalker2_validate;miRNATAP -0.209801751186156 3.89799565892934e-06 NA NA NA hsa-miR-374a-5p NOTCH2 0.016390363747302 0.869784217438621 -0.382079512558875 0.00411077346024402 mirMAP -0.17868161171818 0.00665715296333492 NA NA NA hsa-miR-324-5p NOTCH4 0.372933276649782 0.00592280066108904 0.457393929366218 0.00011628571269746 miRanda -0.17670223894327 3.54714090286095e-05 NA NA NA hsa-miR-421 NOTCH4 0.941856334694081 6.12167297054077e-08 0.457393929366218 0.00011628571269746 miRanda -0.137917639696252 2.7493693494245e-05 NA NA NA hsa-miR-330-5p NUMB 0.442231058604099 0.0053308560843808 -0.370859953517826 8.47166471600254e-07 miRanda -0.100655660286513 1.33527235384531e-05 NA NA NA hsa-miR-339-5p NUMB 0.280589919878422 0.0355660282647215 -0.370859953517826 8.47166471600254e-07 miRanda -0.134356539729992 1.05070262039705e-06 NA NA NA hsa-miR-589-5p NUMB 1.18593770505086 1.01781241960531e-22 -0.370859953517826 8.47166471600254e-07 miRNATAP -0.109616748608625 0.000156708123874888 NA NA NA hsa-miR-590-5p NUMB -0.103355559980404 0.310027295317092 -0.370859953517826 8.47166471600254e-07 miRanda -0.114813361941571 0.00174255631916842 NA NA NA hsa-miR-122-5p NUMBL -1.23907441373955 4.42181244888642e-06 0.394364764618436 0.0036579584719516 miRNAWalker2_validate;miRTarBase -0.212094536904372 5.98957471128912e-20 NA NA NA hsa-miR-194-3p NUMBL -0.772747277805343 2.9537465170191e-05 0.394364764618436 0.0036579584719516 MirTarget -0.287674952090824 4.42711713824645e-17 NA NA NA hsa-miR-374b-5p NUMBL -0.307538028546424 0.0030079617545972 0.394364764618436 0.0036579584719516 miRNATAP -0.169447557547689 0.00845942582806411 NA NA NA hsa-miR-30c-5p PSEN2 -0.432111642767632 0.000159764714931007 0.387153271232775 0.000693917785616684 miRNATAP -0.188330531569865 0.000105139735356388 NA NA NA hsa-miR-421 PSEN2 0.941856334694081 6.12167297054077e-08 0.387153271232775 0.000693917785616684 miRanda -0.108519834300232 0.000611280907823636 NA NA NA hsa-miR-576-5p RBPJ -0.377452008285847 0.00470735657343984 0.0751185265478251 0.474038384860477 mirMAP -0.160144563271589 2.45790161889113e-05 NA NA NA hsa-miR-616-5p RBPJ 0.150569904638223 0.402836556304524 0.0751185265478251 0.474038384860477 MirTarget -0.13577621610522 1.44489090682626e-06 NA NA NA hsa-miR-664a-3p RBPJ 0.485807855553031 0.000732553249798598 0.0751185265478251 0.474038384860477 mirMAP -0.153572662989111 1.21488994120983e-05 NA NA NA