miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106a-5p AKT3 -0.203919267842652 0.802213958426804 0.457269233600447 0.539326812115034 miRNATAP -0.549479065869633 4.88994896864722e-11 NA NA NA hsa-miR-106b-5p AKT3 -0.297128724729339 0.869294443540749 0.457269233600447 0.539326812115034 miRNATAP -0.910251258276316 1.51432008761514e-23 NA NA NA hsa-miR-107 AKT3 -0.0365118169251648 0.988364120226869 0.457269233600447 0.539326812115034 PITA;miRanda -0.551086378595188 0.000172037624489873 NA NA NA hsa-miR-1275 AKT3 -0.831342050607648 0.0803795852164229 0.457269233600447 0.539326812115034 PITA -0.265795172887599 9.47325565176386e-07 NA NA NA hsa-miR-142-3p AKT3 -0.154235241441331 0.946098054588918 0.457269233600447 0.539326812115034 miRanda -0.196043223886578 0.00627089530211866 NA NA NA hsa-miR-15a-5p AKT3 -0.0674049094129128 0.964835434214123 0.457269233600447 0.539326812115034 miRNAWalker2_validate;miRTarBase;miRNATAP -0.721206491484116 7.61586942839311e-13 NA NA NA hsa-miR-15b-5p AKT3 -0.272614787130877 0.87096541832188 0.457269233600447 0.539326812115034 miRNATAP -0.665977383717092 1.97063059627596e-12 NA NA NA hsa-miR-16-5p AKT3 0.0135949734723564 0.994476223855607 0.457269233600447 0.539326812115034 miRNAWalker2_validate;miRTarBase;miRNATAP -0.746124766270904 9.10401236853758e-16 NA NA NA hsa-miR-17-3p AKT3 0.100221625453134 0.960113387014848 0.457269233600447 0.539326812115034 miRNATAP -0.519758313376015 2.03997342351785e-09 NA NA NA hsa-miR-17-5p AKT3 -0.175448849583061 0.934544015912731 0.457269233600447 0.539326812115034 TargetScan;miRNATAP -0.626536048377156 1.11076874125702e-18 NA NA NA hsa-miR-181b-5p AKT3 0.155313039554487 0.930176779696506 0.457269233600447 0.539326812115034 miRNATAP -0.268064668813324 0.00963449049657038 NA NA NA hsa-miR-20a-5p AKT3 -0.179153323927949 0.928118119139752 0.457269233600447 0.539326812115034 miRNATAP -0.531063551395964 1.32783278364081e-13 NA NA NA hsa-miR-28-3p AKT3 -0.227916837431808 0.935350995840384 0.457269233600447 0.539326812115034 miRNATAP -0.521845591393563 0.00718630427898147 NA NA NA hsa-miR-29a-3p AKT3 0.01127474410284 0.996977020481272 0.457269233600447 0.539326812115034 miRNATAP -0.812359982380835 1.03842433672581e-13 NA NA NA hsa-miR-29b-3p AKT3 -0.104016192263954 0.958988036765397 0.457269233600447 0.539326812115034 miRNATAP -0.677276652111253 9.58518141369729e-17 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-32-3p AKT3 -0.568003960723004 0.13133163420273 0.457269233600447 0.539326812115034 mirMAP -0.563455040593992 1.29815959529041e-22 NA NA NA hsa-miR-320a AKT3 -0.416546433767628 0.840202138616422 0.457269233600447 0.539326812115034 PITA;miRanda;miRNATAP -0.333446337886203 0.00137735387479576 NA NA NA hsa-miR-320b AKT3 -0.23561798088153 0.859222532827992 0.457269233600447 0.539326812115034 PITA;miRanda;miRNATAP -0.247020375326149 0.00854841822062789 NA NA NA hsa-miR-335-3p AKT3 -0.244830745789445 0.88450019116631 0.457269233600447 0.539326812115034 mirMAP -0.579661626156677 1.71660731221086e-14 NA NA NA hsa-miR-33a-3p AKT3 -0.794543849238581 0.0105203072007922 0.457269233600447 0.539326812115034 mirMAP -0.48908545949649 5.69174183767199e-12 NA NA NA hsa-miR-340-5p AKT3 -0.00276909425328853 0.99757361161055 0.457269233600447 0.539326812115034 mirMAP -0.282303409119482 0.00600476945925659 NA NA NA hsa-miR-362-3p AKT3 -0.721040238345347 0.0345881362485733 0.457269233600447 0.539326812115034 miRanda -0.415414242264488 1.82625494243827e-09 NA NA NA hsa-miR-362-5p AKT3 -0.26647467080141 0.752024885130738 0.457269233600447 0.539326812115034 PITA;TargetScan;miRNATAP -0.516617267683569 4.2053666241316e-16 NA NA NA hsa-miR-369-3p AKT3 0.116576891957687 0.83230082995912 0.457269233600447 0.539326812115034 mirMAP -0.2347933374382 0.00901179401751285 NA NA NA hsa-miR-374a-5p AKT3 -0.343007247142618 0.766921280269271 0.457269233600447 0.539326812115034 mirMAP -0.579942468779622 2.643062323348e-06 NA NA NA hsa-miR-374b-5p AKT3 -0.285682091626878 0.83569830479965 0.457269233600447 0.539326812115034 mirMAP -0.684416910019692 6.98155817205318e-09 NA NA NA hsa-miR-421 AKT3 -0.182032017078616 0.734704500318599 0.457269233600447 0.539326812115034 miRanda;mirMAP -0.463766741666901 1.36843495165118e-08 NA NA NA hsa-miR-424-5p AKT3 0.247080963500746 0.870154571783568 0.457269233600447 0.539326812115034 miRNATAP -0.239499066096292 0.00104453067376223 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth liver cancer hsa-miR-501-3p AKT3 -0.753812576327832 0.552763280802254 0.457269233600447 0.539326812115034 miRNATAP -0.497935902986368 2.06014814106823e-10 NA NA NA hsa-miR-502-3p AKT3 -0.481234445251923 0.514301076452422 0.457269233600447 0.539326812115034 miRNATAP -0.644160673294049 1.58962279838432e-12 NA NA NA hsa-miR-502-5p AKT3 -0.708507838520586 0.0261309781860104 0.457269233600447 0.539326812115034 PITA;miRNATAP -0.409328372897747 4.31887851181114e-09 NA NA NA hsa-miR-505-3p AKT3 -0.469094267152605 0.690382680489578 0.457269233600447 0.539326812115034 mirMAP -0.774927841273818 6.77311058531751e-15 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-548o-3p AKT3 -0.191447572716994 0.517725546183501 0.457269233600447 0.539326812115034 mirMAP -0.314174287829114 7.58105126731538e-05 NA NA NA hsa-miR-577 AKT3 -1.06238199218774 0.326056761787754 0.457269233600447 0.539326812115034 mirMAP -0.383091519653111 6.42065724452006e-20 NA NA NA hsa-miR-663b AKT3 0.101100389887233 0.814989939749933 0.457269233600447 0.539326812115034 PITA -0.247711064601903 1.07528758067609e-05 NA NA NA hsa-miR-769-5p AKT3 -0.306614906942583 0.735704301598833 0.457269233600447 0.539326812115034 PITA;miRNATAP -0.8409977584726 1.11686042031466e-14 NA NA NA hsa-miR-93-5p AKT3 -0.611073677204699 0.825297877093193 0.457269233600447 0.539326812115034 miRNATAP -0.762020096686085 6.75211862260925e-18 NA NA NA hsa-miR-335-3p ANGPT1 -0.244830745789445 0.88450019116631 0.0977778089466597 0.805357495886648 mirMAP -0.384135116602422 1.01159777273493e-06 NA NA NA hsa-miR-338-5p ANGPT1 0.484769112400393 0.393961930708873 0.0977778089466597 0.805357495886648 PITA;miRNATAP -0.177740364299624 0.00518868401909091 NA NA NA hsa-miR-429 ANGPT1 -0.456485631615963 0.806240953400535 0.0977778089466597 0.805357495886648 miRanda -0.543644561703191 4.1805658622515e-17 NA NA NA hsa-miR-486-5p ANGPT1 -0.547739229538641 0.696404149927963 0.0977778089466597 0.805357495886648 miRanda -0.160538642519606 0.0064962448168831 NA NA NA hsa-miR-590-3p ANGPT1 -0.279244755376859 0.59126669933662 0.0977778089466597 0.805357495886648 PITA;miRanda;mirMAP -0.606219096542099 2.81190990033823e-19 NA NA NA hsa-miR-135b-5p ANGPT2 0.631573976263484 0.610028066417462 0.309392894337764 0.670261224109307 MirTarget -0.105051791297292 0.00265741114691333 NA NA NA hsa-miR-142-5p ANGPT2 -0.118920788314118 0.929665277963083 0.309392894337764 0.670261224109307 MirTarget -0.150339075137481 0.00359413890982174 NA NA NA hsa-miR-374b-5p ANGPT2 -0.285682091626878 0.83569830479965 0.309392894337764 0.670261224109307 mirMAP -0.265580585116253 0.00080942089212346 NA NA NA hsa-miR-429 ANGPT2 -0.456485631615963 0.806240953400535 0.309392894337764 0.670261224109307 miRanda -0.161149664784058 0.00035323349458173 NA NA NA hsa-miR-491-3p ANGPT2 -0.513850326596847 0.137836285146052 0.309392894337764 0.670261224109307 MirTarget;miRNATAP -0.161241074495523 0.000757336703134151 NA NA NA hsa-miR-590-3p ANGPT2 -0.279244755376859 0.59126669933662 0.309392894337764 0.670261224109307 miRanda -0.161585691174076 0.000702866411229349 NA NA NA hsa-let-7a-3p ATF2 -0.215598045625677 0.85543299203799 -0.200040241393686 0.834704017881278 MirTarget;mirMAP;miRNATAP -0.145456257908776 3.85637550129781e-05 NA NA NA hsa-miR-126-5p ATF2 0.0815213541035824 0.956637332055185 -0.200040241393686 0.834704017881278 mirMAP -0.181642145637599 9.06926162170161e-06 NA NA NA hsa-miR-154-3p ATF2 -0.170366170038505 0.546500133020447 -0.200040241393686 0.834704017881278 MirTarget;miRNATAP -0.105577992235569 0.000669146651960108 NA NA NA hsa-miR-15a-5p ATF2 -0.0674049094129128 0.964835434214123 -0.200040241393686 0.834704017881278 miRNAWalker2_validate -0.118857602902957 0.00217641297884977 NA NA NA hsa-miR-221-3p ATF2 0.0906940388127513 0.959121118272534 -0.200040241393686 0.834704017881278 MirTarget -0.145107508084311 0.000241689651077263 NA NA NA hsa-miR-222-3p ATF2 -0.0265849318772702 0.984005474689108 -0.200040241393686 0.834704017881278 MirTarget -0.148058599020819 2.60269631326679e-05 NA NA NA hsa-miR-26a-5p ATF2 0.00698202897993028 0.997719986197021 -0.200040241393686 0.834704017881278 MirTarget;miRNATAP -0.197558729223936 0.00157372163841153 NA NA NA hsa-miR-26b-5p ATF2 -0.0245931278499594 0.990377966314923 -0.200040241393686 0.834704017881278 MirTarget;miRNATAP -0.183301474614023 1.68583844133298e-05 21901137 Coordinated regulation of ATF2 by miR 26b in γ irradiated lung cancer cells; Concurrent analysis of time-series mRNA and microRNA profiles uncovered that expression of miR-26b was down regulated and its target activating transcription factor 2 ATF2 mRNA was up regulated in γ-irradiated H1299 cells; IR in miR-26b overexpressed H1299 cells could not induce expression of ATF2; From these results we concluded that IR-induced up-regulation of ATF2 was coordinately enhanced by suppression of miR-26b in lung cancer cells which may enhance the effect of IR in the MAPK signaling pathway lung cancer hsa-miR-29a-5p ATF2 -0.31835175571979 0.600442757817281 -0.200040241393686 0.834704017881278 MirTarget;miRNATAP -0.120323969461232 3.64182445454902e-05 NA NA NA hsa-miR-30b-5p ATF2 -0.0121430518253582 0.994622896704513 -0.200040241393686 0.834704017881278 mirMAP -0.16085794620541 2.13160957950525e-07 NA NA NA hsa-miR-30c-5p ATF2 -0.298383882401475 0.865809030482001 -0.200040241393686 0.834704017881278 mirMAP -0.202383254510825 6.22899764468817e-06 NA NA NA hsa-miR-32-3p ATF2 -0.568003960723004 0.13133163420273 -0.200040241393686 0.834704017881278 miRNATAP -0.113919762669886 6.39435255124837e-07 NA NA NA hsa-miR-369-3p ATF2 0.116576891957687 0.83230082995912 -0.200040241393686 0.834704017881278 MirTarget;PITA;miRNATAP -0.189727252765993 3.13392227089755e-09 NA NA NA hsa-miR-374b-5p ATF2 -0.285682091626878 0.83569830479965 -0.200040241393686 0.834704017881278 miRNAWalker2_validate;mirMAP;miRNATAP -0.152741878528855 0.000604480562649164 NA NA NA hsa-miR-17-5p BCL2 -0.175448849583061 0.934544015912731 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.313088312531828 1.57403483137732e-05 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-192-5p BCL2 -0.117345487848223 0.972927287653137 -0.871666186967121 0.244961397784127 miRNAWalker2_validate -0.227903685596688 0.000564938952369163 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-196b-5p BCL2 -0.0840912027031901 0.972112413910242 -0.871666186967121 0.244961397784127 miRNAWalker2_validate -0.126443433292796 0.00925777817775241 NA NA NA hsa-miR-20a-3p BCL2 0.456808229166028 0.57674056136504 -0.871666186967121 0.244961397784127 mirMAP -0.189828863199929 0.00114914427656055 NA NA NA hsa-miR-20a-5p BCL2 -0.179153323927949 0.928118119139752 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.252117244065233 0.000458303345864534 NA NA NA hsa-miR-224-3p BCL2 0.110372723153393 0.749091467231007 -0.871666186967121 0.244961397784127 mirMAP -0.178399757407561 0.00774691671641716 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-224-5p BCL2 -0.240425158977724 0.857351098476517 -0.871666186967121 0.244961397784127 mirMAP -0.301573774179688 5.62748011416914e-07 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 -0.0947200031589666 0.920155111594601 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.410993226860356 0.00011884046804375 NA NA NA hsa-miR-29a-3p BCL2 0.01127474410284 0.996977020481272 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.340900217647213 0.00193580882132839 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29a-5p BCL2 -0.31835175571979 0.600442757817281 -0.871666186967121 0.244961397784127 mirMAP -0.343932614708693 5.20598038228022e-06 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29b-3p BCL2 -0.104016192263954 0.958988036765397 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.269579801072406 0.00119448246860227 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-335-3p BCL2 -0.244830745789445 0.88450019116631 -0.871666186967121 0.244961397784127 mirMAP -0.24751331586752 0.0011768675011956 NA NA NA hsa-miR-33a-5p BCL2 -0.205788753603336 0.853314500865147 -0.871666186967121 0.244961397784127 mirMAP -0.128574385145016 0.00455510277772182 NA NA NA hsa-miR-450b-5p BCL2 -0.0136687538973108 0.983149761399849 -0.871666186967121 0.244961397784127 mirMAP -0.240978719259764 0.00585784315473669 NA NA NA hsa-miR-452-5p BCL2 -0.0504626418153507 0.973874641360401 -0.871666186967121 0.244961397784127 mirMAP -0.275409981212347 0.000609740122960845 NA NA NA hsa-miR-7-5p BCL2 0.209645143210379 0.773705612298441 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase;mirMAP -0.195234863896821 0.000177663908838853 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-let-7a-5p BCL2L1 -0.0620211756550422 0.985006886285188 0.242557541702429 0.890959530804569 TargetScan;miRNATAP -0.267237022843277 0.00149660612153832 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-miR-17-5p BCL2L11 -0.175448849583061 0.934544015912731 -0.0603716706605875 0.954972281715815 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.102312409542984 0.00238702079220161 27044389;23001407 We found that upregulated expression of miR-17 and miR-20a correlates with lack of pro-apoptotic Bim expression; Using hairpin inhibitors we showed that inhibition of miR-17 resulted in enhanced Bim expression in a BL cell line overexpressing the miR-17-92 cluster;miR 17 5p inhibitor enhances chemosensitivity to gemcitabine via upregulating Bim expression in pancreatic cancer cells; In addition miR-17-5p inhibitor upregulated Bim protein expression in a dose-dependent manner without changing the Bim mRNA level and it increased the activity of a luciferase reporter construct containing the Bim-3' untranslated region; These results prove that miR-17-5p negatively regulates Bim at the posttranscriptional level ; lymphoma;pancreatic cancer hsa-let-7a-3p BDNF -0.215598045625677 0.85543299203799 0.502522334318129 0.169334891177907 MirTarget;miRNATAP -0.244157318378319 0.00935451173762819 NA NA NA hsa-miR-15a-5p BDNF -0.0674049094129128 0.964835434214123 0.502522334318129 0.169334891177907 MirTarget;miRNATAP -0.355665776038132 0.000462651707811393 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC liver cancer hsa-miR-15b-5p BDNF -0.272614787130877 0.87096541832188 0.502522334318129 0.169334891177907 MirTarget;miRNATAP -0.321617462225248 0.000753073059525485 NA NA NA hsa-miR-16-5p BDNF 0.0135949734723564 0.994476223855607 0.502522334318129 0.169334891177907 MirTarget;miRNATAP -0.341750126964866 0.000321385062215879 NA NA NA hsa-miR-191-5p BDNF -0.482483793839469 0.815353309051705 0.502522334318129 0.169334891177907 miRNATAP -0.334294944807502 0.000226992770607199 NA NA NA hsa-miR-210-3p BDNF -0.531610638853144 0.78220772117333 0.502522334318129 0.169334891177907 miRNAWalker2_validate;miRTarBase -0.183642191494302 0.0001042604221863 NA NA NA hsa-miR-26b-3p BDNF -0.363222538866814 0.681115126930068 0.502522334318129 0.169334891177907 MirTarget -0.268475122696643 0.00218986725906013 NA NA NA hsa-miR-29b-1-5p BDNF -0.642348119412534 0.293891497238796 0.502522334318129 0.169334891177907 mirMAP -0.212902366897635 0.000389282449514205 NA NA NA hsa-miR-30b-5p BDNF -0.0121430518253582 0.994622896704513 0.502522334318129 0.169334891177907 miRNATAP -0.260284489869932 0.00172972096789126 NA NA NA hsa-miR-32-3p BDNF -0.568003960723004 0.13133163420273 0.502522334318129 0.169334891177907 miRNATAP -0.291628274452174 1.27978861287945e-06 NA NA NA hsa-miR-339-5p BDNF -0.300425087100667 0.712912847076788 0.502522334318129 0.169334891177907 miRanda -0.263405527708753 0.000132027992538123 NA NA NA hsa-miR-33a-3p BDNF -0.794543849238581 0.0105203072007922 0.502522334318129 0.169334891177907 mirMAP -0.189014402176148 0.0084884107105508 NA NA NA hsa-miR-452-3p BDNF -0.167134177977311 0.799008246175244 0.502522334318129 0.169334891177907 MirTarget -0.167787891127089 0.00525081101096434 NA NA NA hsa-miR-577 BDNF -1.06238199218774 0.326056761787754 0.502522334318129 0.169334891177907 mirMAP;miRNATAP -0.178001475560175 4.47308472492026e-05 NA NA NA hsa-miR-589-3p BDNF -0.835836305204965 0.0112001563801511 0.502522334318129 0.169334891177907 MirTarget -0.292493758312755 6.69029402753748e-06 NA NA NA hsa-miR-589-5p BDNF -0.448771545046784 0.722725226273464 0.502522334318129 0.169334891177907 miRNATAP -0.37518450820671 0.00123645876452662 NA NA NA hsa-miR-590-3p BDNF -0.279244755376859 0.59126669933662 0.502522334318129 0.169334891177907 miRanda;mirMAP;miRNATAP -0.323632810694054 3.35708815948861e-06 NA NA NA hsa-miR-7-1-3p BDNF -0.462485777435991 0.665899751398166 0.502522334318129 0.169334891177907 MirTarget -0.33546008099557 4.33647161661503e-05 NA NA NA hsa-miR-199a-5p BRCA1 0.157247797504494 0.935797462797012 -0.102764015489285 0.927953070974427 miRanda -0.148454472574801 0.00544405980134469 NA NA NA hsa-miR-34c-5p BRCA1 -0.018707656771723 0.952788306178575 -0.102764015489285 0.927953070974427 miRanda -0.210400653525301 8.89038699087871e-06 NA NA NA hsa-miR-16-5p CCND1 0.0135949734723564 0.994476223855607 -0.254128537418143 0.890666103231997 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.131352085119981 0.00823300401924536 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-195-5p CCND1 0.343201952346823 0.749622318650888 -0.254128537418143 0.890666103231997 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.135964440478054 0.00272099018653157 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-29c-3p CCND1 0.162451700202704 0.942720457512509 -0.254128537418143 0.890666103231997 mirMAP -0.140688238276882 0.00181263740987372 NA NA NA hsa-miR-125b-5p CCNE1 0.042694645848468 0.980586836124662 -0.280205935660748 0.736508482635676 miRNAWalker2_validate -0.153080131670566 0.000743418271995361 NA NA NA hsa-miR-195-5p CCNE1 0.343201952346823 0.749622318650888 -0.280205935660748 0.736508482635676 miRNAWalker2_validate;MirTarget;miRNATAP -0.17512748753993 0.0030220881483402 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-26a-5p CCNE2 0.00698202897993028 0.997719986197021 -0.154004923605453 0.847304727818299 miRNAWalker2_validate;miRTarBase;miRNATAP -0.357013460089754 0.000842485602706472 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-30a-5p CCNE2 0.219472325612346 0.933954023293816 -0.154004923605453 0.847304727818299 miRNATAP -0.438624147963128 1.0101110606114e-07 NA NA NA hsa-miR-34a-5p CCNE2 -0.50188164870224 0.742034237185732 -0.154004923605453 0.847304727818299 miRNAWalker2_validate;miRTarBase;miRNATAP -0.220025402098138 0.000175922127494152 NA NA NA hsa-miR-34c-5p CCNE2 -0.018707656771723 0.952788306178575 -0.154004923605453 0.847304727818299 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.275859200004622 3.23513835152069e-07 NA NA NA hsa-miR-23b-3p CDK2 -0.10822254818704 0.961352920317636 -0.00941560099946681 0.994105531325921 miRNAWalker2_validate -0.171002677486014 0.00275427306255561 NA NA NA hsa-miR-195-5p CDK4 0.343201952346823 0.749622318650888 -0.0555656491892718 0.974291102166537 miRNAWalker2_validate;miRTarBase -0.178739487005888 1.99144590740755e-06 NA NA NA hsa-miR-34c-5p CDK4 -0.018707656771723 0.952788306178575 -0.0555656491892718 0.974291102166537 miRNAWalker2_validate;miRTarBase -0.109354693621618 0.0030808277323941 NA NA NA hsa-miR-21-5p CDK6 -0.148920887107433 0.970240620972126 0.263751741096359 0.851495006493897 miRNAWalker2_validate;mirMAP -0.322969883377914 4.63783733839343e-05 NA NA NA hsa-miR-22-3p CDK6 0.0592693913158495 0.986564295498741 0.263751741096359 0.851495006493897 miRNAWalker2_validate -0.265335616194499 0.00120632355440899 NA NA NA hsa-let-7c-5p CDKN1A -0.0629831812743404 0.974895834249241 0.0967867865725873 0.953141906484364 MirTarget -0.152073389305065 0.0033021603310084 NA NA NA hsa-miR-101-3p CDKN1A 0.0107754887734437 0.997036362636866 0.0967867865725873 0.953141906484364 MirTarget -0.403803292172332 3.96045856328491e-05 NA NA NA hsa-miR-708-5p CDKN1A -0.0282907993048824 0.974929832201158 0.0967867865725873 0.953141906484364 MirTarget -0.137894178596668 0.00964228236869156 NA NA NA hsa-miR-139-5p CDKN1B -0.0810891026597322 0.928690377743652 -0.152387559025753 0.919619146249378 miRanda -0.128190087040829 0.00102726290927428 NA NA NA hsa-miR-342-3p CDKN1B -0.371626144515113 0.77313668985267 -0.152387559025753 0.919619146249378 miRanda -0.122445542838444 0.00143327458289343 NA NA NA hsa-miR-582-3p CDKN1B -0.2334649592375 0.897678119160318 -0.152387559025753 0.919619146249378 PITA -0.108548795204556 0.00639102913863969 NA NA NA hsa-miR-127-3p CHRM1 0.0756694410683956 0.972625730635758 -0.579836264156174 0.334419632816164 miRNATAP -0.504611612331017 0.00950820335922526 NA NA NA hsa-miR-199a-5p CHRM1 0.157247797504494 0.935797462797012 -0.579836264156174 0.334419632816164 miRanda -0.51423972939242 0.00330738901109465 NA NA NA hsa-miR-199b-5p CHRM1 -0.0396557270992508 0.977172718873203 -0.579836264156174 0.334419632816164 miRanda -0.408917003805511 0.00742981096277789 NA NA NA hsa-miR-30c-2-3p CHRM1 0.242912714924037 0.746927269997556 -0.579836264156174 0.334419632816164 mirMAP -0.719267107717877 0.000197560022158445 NA NA NA hsa-miR-10a-3p CHRM2 -0.0996469316906681 0.882902638592481 0.625556980244063 0.584480655520474 mirMAP -0.677065241197977 3.82028144584312e-05 NA NA NA hsa-miR-126-5p CHRM2 0.0815213541035824 0.956637332055185 0.625556980244063 0.584480655520474 mirMAP -1.15394759992707 1.21615322918769e-05 NA NA NA hsa-miR-142-5p CHRM2 -0.118920788314118 0.929665277963083 0.625556980244063 0.584480655520474 mirMAP -0.836277923312577 5.74164689941996e-06 NA NA NA hsa-miR-16-1-3p CHRM2 0.151694812889216 0.733736501874638 0.625556980244063 0.584480655520474 mirMAP -1.4066482545814 2.09080375862105e-16 NA NA NA hsa-miR-17-5p CHRM2 -0.175448849583061 0.934544015912731 0.625556980244063 0.584480655520474 TargetScan -1.4218942161168 5.05753777641754e-17 NA NA NA hsa-miR-186-5p CHRM2 -0.318786974828757 0.85412722938961 0.625556980244063 0.584480655520474 mirMAP -2.43829570669755 1.11939847603564e-19 NA NA NA hsa-miR-26a-1-3p CHRM2 -0.429875601809349 0.182136384322617 0.625556980244063 0.584480655520474 mirMAP -1.24246465347899 2.13459223682752e-13 NA NA NA hsa-miR-26a-2-3p CHRM2 -0.427772454814258 0.28776911697575 0.625556980244063 0.584480655520474 mirMAP -1.55295417891402 2.91799381248873e-19 NA NA NA hsa-miR-29b-1-5p CHRM2 -0.642348119412534 0.293891497238796 0.625556980244063 0.584480655520474 mirMAP -1.15003586261425 8.43029855131741e-17 NA NA NA hsa-miR-335-3p CHRM2 -0.244830745789445 0.88450019116631 0.625556980244063 0.584480655520474 mirMAP -1.32425393632817 1.83603361655778e-13 NA NA NA hsa-miR-335-5p CHRM2 -0.0284895175847679 0.973380867832231 0.625556980244063 0.584480655520474 miRNAWalker2_validate -1.24035802669494 9.98177163107868e-12 NA NA NA hsa-miR-429 CHRM2 -0.456485631615963 0.806240953400535 0.625556980244063 0.584480655520474 miRanda -1.25413654559127 3.57762921219287e-16 NA NA NA hsa-miR-501-5p CHRM2 -0.834032628506285 0.0582725160418523 0.625556980244063 0.584480655520474 mirMAP -0.703394597144782 3.70398697315992e-06 NA NA NA hsa-miR-542-3p CHRM2 0.188168046511374 0.909252939431573 0.625556980244063 0.584480655520474 miRanda -1.18195116127215 1.94861013237188e-06 NA NA NA hsa-miR-577 CHRM2 -1.06238199218774 0.326056761787754 0.625556980244063 0.584480655520474 mirMAP -0.734688463386279 9.23546459114399e-13 NA NA NA hsa-miR-590-3p CHRM2 -0.279244755376859 0.59126669933662 0.625556980244063 0.584480655520474 mirMAP -1.43845806817184 2.33218630932509e-19 NA NA NA hsa-miR-23b-3p CHUK -0.10822254818704 0.961352920317636 -0.096549775668116 0.93218060129343 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.136584882734319 0.00997084019729046 NA NA NA hsa-let-7d-5p COL1A1 -0.139747701175051 0.934164162708487 0.438435990329701 0.864292898084243 miRNATAP -0.766064785744143 1.6016817620935e-05 NA NA NA hsa-let-7f-5p COL1A1 0.048789917034723 0.987280455481631 0.438435990329701 0.864292898084243 miRNATAP -0.560329240313811 0.00103457425351064 NA NA NA hsa-let-7g-5p COL1A1 -0.200947212961157 0.922992045181955 0.438435990329701 0.864292898084243 miRNATAP -1.08805866113022 8.09265865567941e-11 NA NA NA hsa-miR-106a-5p COL1A1 -0.203919267842652 0.802213958426804 0.438435990329701 0.864292898084243 mirMAP -0.593931044858335 2.86381610600532e-08 NA NA NA hsa-miR-106b-5p COL1A1 -0.297128724729339 0.869294443540749 0.438435990329701 0.864292898084243 mirMAP -0.868848091290003 7.34471291415844e-13 NA NA NA hsa-miR-17-5p COL1A1 -0.175448849583061 0.934544015912731 0.438435990329701 0.864292898084243 mirMAP -0.614329957433093 4.150042863716e-11 NA NA NA hsa-miR-196a-5p COL1A1 -0.0569856738232488 0.973093117800687 0.438435990329701 0.864292898084243 miRNATAP -0.339199100336278 1.32445619682025e-07 NA NA NA hsa-miR-196b-5p COL1A1 -0.0840912027031901 0.972112413910242 0.438435990329701 0.864292898084243 miRNATAP -0.249368481502057 8.64610406092119e-05 NA NA NA hsa-miR-20a-5p COL1A1 -0.179153323927949 0.928118119139752 0.438435990329701 0.864292898084243 mirMAP -0.550833262704154 2.6573275393739e-09 NA NA NA hsa-miR-23a-5p COL1A1 -0.697299079757902 0.1188853327314 0.438435990329701 0.864292898084243 mirMAP -0.189710406836719 0.00786908687449384 NA NA NA hsa-miR-29a-3p COL1A1 0.01127474410284 0.996977020481272 0.438435990329701 0.864292898084243 miRNATAP -0.919778638760987 4.73987888175994e-11 NA NA NA hsa-miR-29b-3p COL1A1 -0.104016192263954 0.958988036765397 0.438435990329701 0.864292898084243 miRNAWalker2_validate;miRTarBase;miRNATAP -0.676671654044059 1.86471447534431e-10 NA NA NA hsa-miR-30b-3p COL1A1 -0.514644352757504 0.162424853398397 0.438435990329701 0.864292898084243 miRNATAP -0.550964244280372 1.61151199239072e-07 NA NA NA hsa-miR-30d-3p COL1A1 -0.123474741320298 0.814905367625791 0.438435990329701 0.864292898084243 mirMAP -0.78250759896813 4.04296550527539e-11 NA NA NA hsa-miR-30e-3p COL1A1 -0.220498559176349 0.938660731870214 0.438435990329701 0.864292898084243 mirMAP -1.09090944670785 3.89886107545339e-08 NA NA NA hsa-miR-532-3p COL1A1 -0.496590111092324 0.682889021782543 0.438435990329701 0.864292898084243 PITA;miRNATAP -0.569481338293528 3.9977206704821e-09 NA NA NA hsa-miR-577 COL1A1 -1.06238199218774 0.326056761787754 0.438435990329701 0.864292898084243 MirTarget;PITA;miRNATAP -0.375904507583292 9.1531618964867e-12 NA NA NA hsa-miR-590-3p COL1A1 -0.279244755376859 0.59126669933662 0.438435990329701 0.864292898084243 miRanda -0.562627916423983 2.79233229419961e-10 NA NA NA hsa-miR-625-5p COL1A1 -0.690759472145277 0.210306534567564 0.438435990329701 0.864292898084243 MirTarget -0.351043847306495 1.21835528637583e-05 NA NA NA hsa-miR-92a-1-5p COL1A1 -0.114476130048015 0.848528800127198 0.438435990329701 0.864292898084243 MirTarget -0.495230356675248 4.37040026104547e-09 NA NA NA hsa-miR-93-5p COL1A1 -0.611073677204699 0.825297877093193 0.438435990329701 0.864292898084243 mirMAP -0.609745129807015 2.17989574436952e-07 NA NA NA hsa-let-7a-3p COL1A2 -0.215598045625677 0.85543299203799 0.454328350754551 0.851346205358441 MirTarget -0.575582831050776 5.0312162680722e-07 NA NA NA hsa-let-7d-5p COL1A2 -0.139747701175051 0.934164162708487 0.454328350754551 0.851346205358441 MirTarget;miRNATAP -0.866662281592524 2.33557931663316e-07 NA NA NA hsa-let-7f-1-3p COL1A2 -0.31101436822914 0.693407210545374 0.454328350754551 0.851346205358441 MirTarget -0.774910161436362 7.39870649861457e-07 NA NA NA hsa-let-7f-5p COL1A2 0.048789917034723 0.987280455481631 0.454328350754551 0.851346205358441 MirTarget;miRNATAP -0.565311541742977 0.000501392779528516 NA NA NA hsa-let-7g-5p COL1A2 -0.200947212961157 0.922992045181955 0.454328350754551 0.851346205358441 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -1.15520606379076 2.19925811825158e-13 NA NA NA hsa-miR-1275 COL1A2 -0.831342050607648 0.0803795852164229 0.454328350754551 0.851346205358441 MirTarget -0.267342019012468 4.82635789352029e-05 NA NA NA hsa-miR-196a-5p COL1A2 -0.0569856738232488 0.973093117800687 0.454328350754551 0.851346205358441 MirTarget;miRNATAP -0.333230404941418 4.98598500322717e-08 NA NA NA hsa-miR-196b-5p COL1A2 -0.0840912027031901 0.972112413910242 0.454328350754551 0.851346205358441 MirTarget;miRNATAP -0.217712700837931 0.000333906925928418 NA NA NA hsa-miR-19a-3p COL1A2 -0.206793507801887 0.844637784802316 0.454328350754551 0.851346205358441 MirTarget -0.493738369466429 7.01027271034339e-09 NA NA NA hsa-miR-19b-3p COL1A2 -0.0268530183621474 0.986656783046572 0.454328350754551 0.851346205358441 MirTarget -0.680913660781536 1.30504235202314e-11 NA NA NA hsa-miR-25-3p COL1A2 -0.457540448732733 0.878574066837636 0.454328350754551 0.851346205358441 MirTarget;miRNATAP -0.795457753876812 3.8848513432899e-08 NA NA NA hsa-miR-26a-5p COL1A2 0.00698202897993028 0.997719986197021 0.454328350754551 0.851346205358441 MirTarget;miRNATAP -0.639049404853653 0.00178230252343263 NA NA NA hsa-miR-26b-5p COL1A2 -0.0245931278499594 0.990377966314923 0.454328350754551 0.851346205358441 MirTarget;miRNATAP -0.994324674331331 1.07044001873112e-13 NA NA NA hsa-miR-29a-3p COL1A2 0.01127474410284 0.996977020481272 0.454328350754551 0.851346205358441 miRNATAP -0.987215305965917 5.41134653774212e-14 NA NA NA hsa-miR-29b-3p COL1A2 -0.104016192263954 0.958988036765397 0.454328350754551 0.851346205358441 miRNATAP -0.730682126424017 2.33763175252563e-13 NA NA NA hsa-miR-30d-3p COL1A2 -0.123474741320298 0.814905367625791 0.454328350754551 0.851346205358441 MirTarget -0.809172887101712 4.59963413190695e-13 NA NA NA hsa-miR-30e-3p COL1A2 -0.220498559176349 0.938660731870214 0.454328350754551 0.851346205358441 MirTarget -1.04845921560558 2.89437162142994e-08 NA NA NA hsa-miR-32-3p COL1A2 -0.568003960723004 0.13133163420273 0.454328350754551 0.851346205358441 miRNATAP -0.520731252143186 7.79469518859106e-13 NA NA NA hsa-miR-32-5p COL1A2 -0.05993267619119 0.952975951594959 0.454328350754551 0.851346205358441 MirTarget;miRNATAP -0.662708300249598 2.08596572913046e-11 NA NA NA hsa-miR-33a-3p COL1A2 -0.794543849238581 0.0105203072007922 0.454328350754551 0.851346205358441 MirTarget -0.427843136638003 1.07364778964369e-06 NA NA NA hsa-miR-500a-5p COL1A2 -0.71978560736831 0.188073776225276 0.454328350754551 0.851346205358441 miRNATAP -0.454328125693928 2.67205055908206e-07 NA NA NA hsa-miR-552-3p COL1A2 0.172135417326455 0.893972136172394 0.454328350754551 0.851346205358441 MirTarget -0.155344020377527 0.00185404494011989 NA NA NA hsa-miR-590-3p COL1A2 -0.279244755376859 0.59126669933662 0.454328350754551 0.851346205358441 miRanda -0.613121189644527 2.30626854026007e-13 NA NA NA hsa-miR-7-1-3p COL1A2 -0.462485777435991 0.665899751398166 0.454328350754551 0.851346205358441 mirMAP -0.680794302957845 5.23410456139963e-12 NA NA NA hsa-miR-7-5p COL1A2 0.209645143210379 0.773705612298441 0.454328350754551 0.851346205358441 miRNATAP -0.265951319121316 4.66218901963704e-05 NA NA NA hsa-miR-92a-3p COL1A2 0.0278830870766349 0.993247426671713 0.454328350754551 0.851346205358441 MirTarget;miRNATAP -0.721516973154382 3.54414089044421e-12 NA NA NA hsa-miR-98-5p COL1A2 -0.168162186023221 0.898802461503524 0.454328350754551 0.851346205358441 MirTarget -0.526804311821611 0.000210154381219699 NA NA NA hsa-let-7a-3p COL4A1 -0.215598045625677 0.85543299203799 0.390705250339176 0.843526595048209 miRNATAP -0.365653907996656 1.58962960214704e-07 NA NA NA hsa-let-7g-5p COL4A1 -0.200947212961157 0.922992045181955 0.390705250339176 0.843526595048209 miRNATAP -0.481238700218733 1.30215542066056e-06 NA NA NA hsa-miR-148a-3p COL4A1 -0.101286586375016 0.976980454193186 0.390705250339176 0.843526595048209 miRNATAP -0.298011506255659 4.86405594010646e-06 NA NA NA hsa-miR-16-5p COL4A1 0.0135949734723564 0.994476223855607 0.390705250339176 0.843526595048209 miRNAWalker2_validate -0.423327973772882 1.76540449784425e-09 NA NA NA hsa-miR-17-5p COL4A1 -0.175448849583061 0.934544015912731 0.390705250339176 0.843526595048209 TargetScan -0.237574404176178 1.99964324659802e-05 NA NA NA hsa-miR-18a-3p COL4A1 -0.270443061178857 0.535291623032886 0.390705250339176 0.843526595048209 miRNAWalker2_validate -0.161296428868577 0.000538804867552811 NA NA NA hsa-miR-29a-3p COL4A1 0.01127474410284 0.996977020481272 0.390705250339176 0.843526595048209 miRNAWalker2_validate;miRTarBase;miRNATAP -0.600467231354941 6.91543223019375e-14 NA NA NA hsa-miR-29b-3p COL4A1 -0.104016192263954 0.958988036765397 0.390705250339176 0.843526595048209 miRNAWalker2_validate;miRTarBase;miRNATAP -0.370047428715388 2.56215248445765e-09 NA NA NA hsa-miR-362-3p COL4A1 -0.721040238345347 0.0345881362485733 0.390705250339176 0.843526595048209 miRanda -0.226246379104217 1.2202604409576e-05 NA NA NA hsa-miR-429 COL4A1 -0.456485631615963 0.806240953400535 0.390705250339176 0.843526595048209 miRanda;miRNATAP -0.293095697413151 2.91657614676704e-09 NA NA NA hsa-miR-590-3p COL4A1 -0.279244755376859 0.59126669933662 0.390705250339176 0.843526595048209 miRanda -0.333578163727805 1.1595686243061e-10 NA NA NA hsa-miR-590-5p COL4A1 -0.547819833829572 0.472735645776647 0.390705250339176 0.843526595048209 miRanda;miRNATAP -0.350974654929609 1.46426691589682e-10 NA NA NA hsa-miR-769-3p COL4A1 -0.725526264793959 0.0191991711154544 0.390705250339176 0.843526595048209 miRNAWalker2_validate -0.191911931847475 0.000302657512328264 NA NA NA hsa-miR-92a-3p COL4A1 0.0278830870766349 0.993247426671713 0.390705250339176 0.843526595048209 miRNAWalker2_validate -0.306157778071274 2.68449616751774e-06 NA NA NA hsa-let-7f-5p COL4A2 0.048789917034723 0.987280455481631 0.392029609275019 0.844574408150645 miRNATAP -0.297799199393874 0.00264283625525785 NA NA NA hsa-let-7g-5p COL4A2 -0.200947212961157 0.922992045181955 0.392029609275019 0.844574408150645 miRNATAP -0.576204521263209 3.7141890702929e-09 NA NA NA hsa-miR-10a-5p COL4A2 0.0740585720685925 0.983770933356406 0.392029609275019 0.844574408150645 miRNAWalker2_validate -0.351874489991799 3.509559305596e-09 NA NA NA hsa-miR-1266-5p COL4A2 -0.749998297098308 0.475802062565143 0.392029609275019 0.844574408150645 MirTarget -0.220220341683826 1.39987019332153e-06 NA NA NA hsa-miR-16-5p COL4A2 0.0135949734723564 0.994476223855607 0.392029609275019 0.844574408150645 miRNAWalker2_validate -0.460295512110166 3.32021179961754e-11 NA NA NA hsa-miR-26b-5p COL4A2 -0.0245931278499594 0.990377966314923 0.392029609275019 0.844574408150645 miRNAWalker2_validate -0.51925072907853 3.46263963767971e-10 NA NA NA hsa-miR-29a-3p COL4A2 0.01127474410284 0.996977020481272 0.392029609275019 0.844574408150645 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.573681351453564 8.65242300704714e-13 NA NA NA hsa-miR-29b-3p COL4A2 -0.104016192263954 0.958988036765397 0.392029609275019 0.844574408150645 miRTarBase;MirTarget;miRNATAP -0.377122764380551 9.77478714276408e-10 NA NA NA hsa-miR-30c-1-3p COL4A2 -0.202466672579761 0.511485842123022 0.392029609275019 0.844574408150645 MirTarget -0.248091524277076 4.94296246083895e-06 NA NA NA hsa-miR-92a-3p COL4A2 0.0278830870766349 0.993247426671713 0.392029609275019 0.844574408150645 miRNAWalker2_validate -0.384884252603365 1.70159760778301e-09 NA NA NA hsa-miR-106b-5p COL4A3 -0.297128724729339 0.869294443540749 0.484513271448509 0.580999876119749 MirTarget;miRNATAP -0.67341524065958 0.000337393168915739 NA NA NA hsa-miR-10a-5p COL4A3 0.0740585720685925 0.983770933356406 0.484513271448509 0.580999876119749 miRNAWalker2_validate -0.565097167910671 0.000310682819823591 NA NA NA hsa-miR-135b-5p COL4A3 0.631573976263484 0.610028066417462 0.484513271448509 0.580999876119749 MirTarget -0.391125438188396 8.48296199634823e-05 NA NA NA hsa-miR-15b-3p COL4A3 -0.557749208157585 0.609181305423188 0.484513271448509 0.580999876119749 mirMAP -0.510953494465974 0.00250233751228346 NA NA NA hsa-miR-17-5p COL4A3 -0.175448849583061 0.934544015912731 0.484513271448509 0.580999876119749 MirTarget;TargetScan;miRNATAP -0.441635852439645 0.0021145352808677 NA NA NA hsa-miR-193a-3p COL4A3 -0.247265785363732 0.654363581941634 0.484513271448509 0.580999876119749 miRanda -0.400201613688616 0.00964455759163031 NA NA NA hsa-miR-200c-3p COL4A3 -0.437282635857873 0.887118598436407 0.484513271448509 0.580999876119749 miRNATAP -0.558104859084108 0.000693847872500437 NA NA NA hsa-miR-29a-3p COL4A3 0.01127474410284 0.996977020481272 0.484513271448509 0.580999876119749 MirTarget;miRNATAP -0.568665013644278 0.00857188342123929 NA NA NA hsa-miR-29a-5p COL4A3 -0.31835175571979 0.600442757817281 0.484513271448509 0.580999876119749 mirMAP -0.58712669886282 8.05263724112923e-05 NA NA NA hsa-miR-29b-3p COL4A3 -0.104016192263954 0.958988036765397 0.484513271448509 0.580999876119749 MirTarget;miRNATAP -0.532650954896892 0.00109420214709942 NA NA NA hsa-miR-335-3p COL4A3 -0.244830745789445 0.88450019116631 0.484513271448509 0.580999876119749 mirMAP -0.497554587958118 0.000875713540279387 NA NA NA hsa-miR-429 COL4A3 -0.456485631615963 0.806240953400535 0.484513271448509 0.580999876119749 miRanda;miRNATAP -0.388690396446969 0.00276676335481882 NA NA NA hsa-miR-501-3p COL4A3 -0.753812576327832 0.552763280802254 0.484513271448509 0.580999876119749 miRNATAP -0.547324602234685 0.000303733497504593 NA NA NA hsa-miR-502-3p COL4A3 -0.481234445251923 0.514301076452422 0.484513271448509 0.580999876119749 miRNATAP -0.691646919734758 0.000100074584485965 NA NA NA hsa-miR-590-3p COL4A3 -0.279244755376859 0.59126669933662 0.484513271448509 0.580999876119749 miRanda -0.409730844818665 0.00280838524176462 NA NA NA hsa-miR-625-5p COL4A3 -0.690759472145277 0.210306534567564 0.484513271448509 0.580999876119749 MirTarget -0.413935342113624 0.000573414054349347 NA NA NA hsa-miR-7-1-3p COL4A3 -0.462485777435991 0.665899751398166 0.484513271448509 0.580999876119749 MirTarget -0.464198259002116 0.00388907739556781 NA NA NA hsa-miR-93-3p COL4A3 -0.438355548962673 0.549902689385444 0.484513271448509 0.580999876119749 miRNATAP -0.611354879518677 0.000109680850107676 NA NA NA hsa-miR-93-5p COL4A3 -0.611073677204699 0.825297877093193 0.484513271448509 0.580999876119749 MirTarget;miRNATAP -0.553532415235941 0.00189148461235276 NA NA NA hsa-let-7f-1-3p COL4A4 -0.31101436822914 0.693407210545374 0.394923766106945 0.423453123981739 mirMAP -0.54654950960976 0.00571435601465069 NA NA NA hsa-miR-130b-3p COL4A4 -0.221667315324818 0.824660172394714 0.394923766106945 0.423453123981739 mirMAP -0.614458466185864 3.60712088540017e-06 NA NA NA hsa-miR-15b-3p COL4A4 -0.557749208157585 0.609181305423188 0.394923766106945 0.423453123981739 MirTarget -0.524965273429085 8.30395352004871e-05 NA NA NA hsa-miR-186-5p COL4A4 -0.318786974828757 0.85412722938961 0.394923766106945 0.423453123981739 mirMAP -0.508986074253545 0.00558904810141969 NA NA NA hsa-miR-203a-3p COL4A4 -0.265248086637561 0.931593594361942 0.394923766106945 0.423453123981739 MirTarget -0.417176147750781 1.43876210660748e-05 NA NA NA hsa-miR-224-3p COL4A4 0.110372723153393 0.749091467231007 0.394923766106945 0.423453123981739 mirMAP -0.273722359806821 0.00878932524428407 NA NA NA hsa-miR-29a-3p COL4A4 0.01127474410284 0.996977020481272 0.394923766106945 0.423453123981739 MirTarget;miRNATAP -0.454317000857327 0.00823974831032669 NA NA NA hsa-miR-29b-3p COL4A4 -0.104016192263954 0.958988036765397 0.394923766106945 0.423453123981739 MirTarget;miRNATAP -0.472643479121587 0.000256282759066483 NA NA NA hsa-miR-301a-3p COL4A4 -0.105312511901769 0.831686745977347 0.394923766106945 0.423453123981739 mirMAP -0.471041261553046 2.80162485742541e-05 NA NA NA hsa-miR-33a-3p COL4A4 -0.794543849238581 0.0105203072007922 0.394923766106945 0.423453123981739 mirMAP -0.356193822477651 0.00125117509459645 NA NA NA hsa-miR-429 COL4A4 -0.456485631615963 0.806240953400535 0.394923766106945 0.423453123981739 miRNATAP -0.323783572730036 0.00169465317026085 NA NA NA hsa-miR-454-3p COL4A4 -0.101514866328011 0.843545158256191 0.394923766106945 0.423453123981739 mirMAP -0.424888661533486 0.00657644073379633 NA NA NA hsa-miR-491-3p COL4A4 -0.513850326596847 0.137836285146052 0.394923766106945 0.423453123981739 PITA;miRNATAP -0.387824156990521 0.000371588265969949 NA NA NA hsa-miR-501-5p COL4A4 -0.834032628506285 0.0582725160418523 0.394923766106945 0.423453123981739 mirMAP -0.320177434065411 0.000945896116607046 NA NA NA hsa-miR-532-3p COL4A4 -0.496590111092324 0.682889021782543 0.394923766106945 0.423453123981739 miRNATAP -0.540497586552253 3.13437808961942e-06 NA NA NA hsa-miR-539-5p COL4A4 0.124342970087029 0.801067485473643 0.394923766106945 0.423453123981739 mirMAP -0.42757541475389 0.00287485266815677 NA NA NA hsa-miR-576-5p COL4A4 -0.506413219377403 0.417187951364173 0.394923766106945 0.423453123981739 PITA -0.457782837359412 0.000443836385131155 NA NA NA hsa-miR-577 COL4A4 -1.06238199218774 0.326056761787754 0.394923766106945 0.423453123981739 mirMAP -0.316142595386362 2.26839472422321e-06 NA NA NA hsa-miR-589-3p COL4A4 -0.835836305204965 0.0112001563801511 0.394923766106945 0.423453123981739 mirMAP -0.326884584861733 0.00125904332615455 NA NA NA hsa-miR-590-3p COL4A4 -0.279244755376859 0.59126669933662 0.394923766106945 0.423453123981739 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.423519393171059 9.09542836882477e-05 NA NA NA hsa-miR-146b-5p COL4A5 -0.402662509440887 0.837510937985091 -0.513019267798925 0.387633969020295 miRanda -0.559194668069909 0.00108656814758199 NA NA NA hsa-miR-338-5p COL4A5 0.484769112400393 0.393961930708873 -0.513019267798925 0.387633969020295 PITA;miRNATAP -0.299286478337118 0.00625619797845435 NA NA NA hsa-miR-324-5p COL6A1 -0.50063248413014 0.537416710557032 0.190011072147575 0.918296216204497 miRNAWalker2_validate -0.329228285848431 0.000189095239903577 NA NA NA hsa-miR-335-5p COL6A1 -0.0284895175847679 0.973380867832231 0.190011072147575 0.918296216204497 miRNAWalker2_validate -0.587929505579588 4.4482151717906e-16 NA NA NA hsa-miR-10a-5p COL6A2 0.0740585720685925 0.983770933356406 0.318068613062445 0.869868351100168 miRNAWalker2_validate -0.509117494269021 1.45906987251488e-10 NA NA NA hsa-miR-1226-3p COL6A3 -0.346825224699346 0.341199987121208 0.287936930688113 0.887618003460968 MirTarget -0.267170051990486 0.000964801024419401 NA NA NA hsa-miR-1254 COL6A3 -0.488929355953681 0.19551794273322 0.287936930688113 0.887618003460968 miRNATAP -0.253924166921096 0.00154461001700307 NA NA NA hsa-miR-29a-3p COL6A3 0.01127474410284 0.996977020481272 0.287936930688113 0.887618003460968 MirTarget;miRNATAP -1.02857322168935 1.25090931818389e-16 NA NA NA hsa-miR-29b-3p COL6A3 -0.104016192263954 0.958988036765397 0.287936930688113 0.887618003460968 MirTarget;miRNATAP -0.751614782105813 2.01918928009249e-15 NA NA NA hsa-miR-320a COL6A3 -0.416546433767628 0.840202138616422 0.287936930688113 0.887618003460968 miRanda -0.356791189431176 0.00305729634226602 NA NA NA hsa-miR-362-3p COL6A3 -0.721040238345347 0.0345881362485733 0.287936930688113 0.887618003460968 miRanda -0.417610356035077 2.16770282441953e-07 NA NA NA hsa-miR-429 COL6A3 -0.456485631615963 0.806240953400535 0.287936930688113 0.887618003460968 miRNATAP -0.634996874386062 1.44703562651995e-17 NA NA NA hsa-miR-590-3p COL6A3 -0.279244755376859 0.59126669933662 0.287936930688113 0.887618003460968 miRanda -0.621781690967172 5.60058968993303e-15 NA NA NA hsa-miR-877-5p COL6A3 -0.317720731672575 0.435952264022643 0.287936930688113 0.887618003460968 MirTarget;miRNATAP -0.249585375192163 0.000676674748749834 NA NA NA hsa-miR-146b-5p COL9A1 -0.402662509440887 0.837510937985091 1.11947038451616 0.119587299570099 miRanda;miRNATAP -1.38802892502361 3.96207410188797e-11 NA NA NA hsa-miR-150-3p COL9A1 -0.286685702312492 0.514273847346768 1.11947038451616 0.119587299570099 miRNATAP -0.48534720127993 6.742351137966e-05 NA NA NA hsa-miR-32-3p COL9A1 -0.568003960723004 0.13133163420273 1.11947038451616 0.119587299570099 mirMAP -0.394475791245699 0.0045441021888106 NA NA NA hsa-miR-590-3p COL9A1 -0.279244755376859 0.59126669933662 1.11947038451616 0.119587299570099 miRanda -0.477149101182542 0.00290852465903127 NA NA NA hsa-miR-7-1-3p COL9A1 -0.462485777435991 0.665899751398166 1.11947038451616 0.119587299570099 mirMAP -0.613683301492107 0.0010573771085322 NA NA NA hsa-miR-133b COL9A2 0.392161188688359 0.560763234081075 -0.148036077664798 0.863743931745095 miRanda -0.155945428402106 0.00913259704330345 NA NA NA hsa-let-7a-5p COL9A3 -0.0620211756550422 0.985006886285188 1.64347756396576 0.0688520501902136 TargetScan -0.800643033081893 0.00547798187275623 NA NA NA hsa-miR-486-5p COL9A3 -0.547739229538641 0.696404149927963 1.64347756396576 0.0688520501902136 miRanda -0.282230233965697 0.00802298207162906 NA NA NA hsa-miR-126-5p CREB1 0.0815213541035824 0.956637332055185 -0.0890235121600922 0.942769369756648 mirMAP -0.1035952859282 7.4133948008438e-06 NA NA NA hsa-miR-27a-3p CREB1 -0.123902317731458 0.958804393510999 -0.0890235121600922 0.942769369756648 MirTarget -0.139448205184029 1.13639902690819e-06 NA NA NA hsa-miR-30e-5p CREB1 -0.0657075181381011 0.979684509181941 -0.0890235121600922 0.942769369756648 MirTarget;mirMAP -0.100988124363091 0.000348172215034425 NA NA NA hsa-let-7f-5p CREB3L2 0.048789917034723 0.987280455481631 -0.189725248233904 0.900196136958275 mirMAP -0.181107323879137 0.00582828209903886 NA NA NA hsa-let-7g-5p CREB3L2 -0.200947212961157 0.922992045181955 -0.189725248233904 0.900196136958275 mirMAP -0.211859258297906 0.00144600758229778 NA NA NA hsa-miR-17-5p CREB3L2 -0.175448849583061 0.934544015912731 -0.189725248233904 0.900196136958275 mirMAP -0.112601171356512 0.00239033969676186 NA NA NA hsa-miR-181b-5p CREB3L2 0.155313039554487 0.930176779696506 -0.189725248233904 0.900196136958275 mirMAP -0.137935340809896 0.00586791627130323 NA NA NA hsa-miR-181c-5p CREB3L2 0.042951891660695 0.969159991881861 -0.189725248233904 0.900196136958275 mirMAP -0.115364412908177 0.00945580384724816 NA NA NA hsa-miR-19b-3p CREB3L2 -0.0268530183621474 0.986656783046572 -0.189725248233904 0.900196136958275 miRNAWalker2_validate -0.167744596851393 6.08983419035913e-05 NA NA NA hsa-miR-200a-3p CREB3L2 -0.367034437440907 0.851059894150266 -0.189725248233904 0.900196136958275 MirTarget -0.106674824683821 0.00231993084654069 NA NA NA hsa-miR-20a-5p CREB3L2 -0.179153323927949 0.928118119139752 -0.189725248233904 0.900196136958275 mirMAP -0.104466765325246 0.00428578468685288 NA NA NA hsa-miR-32-5p CREB3L2 -0.05993267619119 0.952975951594959 -0.189725248233904 0.900196136958275 MirTarget;miRNATAP -0.144299321428318 0.000471839895481918 NA NA NA hsa-miR-429 CREB3L2 -0.456485631615963 0.806240953400535 -0.189725248233904 0.900196136958275 miRNATAP -0.106768247847677 0.00141923733941118 NA NA NA hsa-miR-92a-3p CREB3L2 0.0278830870766349 0.993247426671713 -0.189725248233904 0.900196136958275 miRNAWalker2_validate;MirTarget;miRNATAP -0.128803948938571 0.00315610521391432 NA NA NA hsa-miR-96-5p CREB3L2 0.0854810872029343 0.923087820185031 -0.189725248233904 0.900196136958275 MirTarget;TargetScan;miRNATAP -0.128655396457868 0.000377878080895403 NA NA NA hsa-miR-98-5p CREB3L2 -0.168162186023221 0.898802461503524 -0.189725248233904 0.900196136958275 mirMAP -0.155003660072165 0.00712176553077711 NA NA NA hsa-miR-106b-5p CREB5 -0.297128724729339 0.869294443540749 0.312334189082537 0.59369034352436 MirTarget;miRNATAP -0.440387736254802 0.00013709201854506 NA NA NA hsa-miR-10a-3p CREB5 -0.0996469316906681 0.882902638592481 0.312334189082537 0.59369034352436 mirMAP -0.209124696895921 0.00996459437736248 NA NA NA hsa-miR-130b-3p CREB5 -0.221667315324818 0.824660172394714 0.312334189082537 0.59369034352436 miRNATAP -0.402854372751421 9.93303361237379e-05 NA NA NA hsa-miR-141-3p CREB5 -0.31994058840327 0.87774106909065 0.312334189082537 0.59369034352436 mirMAP -0.294997278086238 0.000569842695062087 NA NA NA hsa-miR-15a-5p CREB5 -0.0674049094129128 0.964835434214123 0.312334189082537 0.59369034352436 miRNATAP -0.365694000950227 0.00270071791819687 NA NA NA hsa-miR-15b-5p CREB5 -0.272614787130877 0.87096541832188 0.312334189082537 0.59369034352436 miRNATAP -0.417281562608091 0.000247440151397623 NA NA NA hsa-miR-16-2-3p CREB5 -0.36717860153421 0.546850726070016 0.312334189082537 0.59369034352436 mirMAP -0.350285053252546 0.000147888595096418 NA NA NA hsa-miR-16-5p CREB5 0.0135949734723564 0.994476223855607 0.312334189082537 0.59369034352436 miRNATAP -0.44789194064114 7.64683076688539e-05 NA NA NA hsa-miR-186-5p CREB5 -0.318786974828757 0.85412722938961 0.312334189082537 0.59369034352436 mirMAP -0.510944801671531 0.000303948912789361 NA NA NA hsa-miR-19a-3p CREB5 -0.206793507801887 0.844637784802316 0.312334189082537 0.59369034352436 mirMAP -0.251543120220852 0.00281019206195158 NA NA NA hsa-miR-200a-3p CREB5 -0.367034437440907 0.851059894150266 0.312334189082537 0.59369034352436 mirMAP -0.311440011556083 0.000180576533039607 NA NA NA hsa-miR-200b-3p CREB5 -0.426401948379212 0.863957108574195 0.312334189082537 0.59369034352436 TargetScan -0.36139919612791 0.000234842492854121 NA NA NA hsa-miR-26b-5p CREB5 -0.0245931278499594 0.990377966314923 0.312334189082537 0.59369034352436 mirMAP -0.434046260183765 0.00131471066736517 NA NA NA hsa-miR-30d-3p CREB5 -0.123474741320298 0.814905367625791 0.312334189082537 0.59369034352436 mirMAP -0.304665026871382 0.00698796027990033 NA NA NA hsa-miR-32-3p CREB5 -0.568003960723004 0.13133163420273 0.312334189082537 0.59369034352436 mirMAP -0.25726298333741 0.000417260308036327 NA NA NA hsa-miR-32-5p CREB5 -0.05993267619119 0.952975951594959 0.312334189082537 0.59369034352436 miRNAWalker2_validate -0.402119127087316 4.09282452686244e-05 NA NA NA hsa-miR-362-3p CREB5 -0.721040238345347 0.0345881362485733 0.312334189082537 0.59369034352436 PITA -0.24818771859261 0.00256449683559378 NA NA NA hsa-miR-362-5p CREB5 -0.26647467080141 0.752024885130738 0.312334189082537 0.59369034352436 PITA -0.210700780659323 0.0071794397206792 NA NA NA hsa-miR-429 CREB5 -0.456485631615963 0.806240953400535 0.312334189082537 0.59369034352436 PITA;miRanda;miRNATAP -0.294148791075978 0.000218629457993234 NA NA NA hsa-miR-500a-5p CREB5 -0.71978560736831 0.188073776225276 0.312334189082537 0.59369034352436 mirMAP -0.265711137896622 0.00211572346125784 NA NA NA hsa-miR-532-3p CREB5 -0.496590111092324 0.682889021782543 0.312334189082537 0.59369034352436 miRNATAP -0.26714921717147 0.00339125249993746 NA NA NA hsa-miR-576-5p CREB5 -0.506413219377403 0.417187951364173 0.312334189082537 0.59369034352436 PITA;mirMAP -0.360487681497295 0.000354957766100494 NA NA NA hsa-miR-590-3p CREB5 -0.279244755376859 0.59126669933662 0.312334189082537 0.59369034352436 PITA;mirMAP -0.219540137272947 0.00952044947097866 NA NA NA hsa-miR-590-5p CREB5 -0.547819833829572 0.472735645776647 0.312334189082537 0.59369034352436 miRNATAP -0.327383762389702 0.000228729007315894 NA NA NA hsa-miR-7-1-3p CREB5 -0.462485777435991 0.665899751398166 0.312334189082537 0.59369034352436 mirMAP -0.290456741848918 0.00334872806489483 NA NA NA hsa-miR-93-5p CREB5 -0.611073677204699 0.825297877093193 0.312334189082537 0.59369034352436 MirTarget;miRNATAP -0.302971252577292 0.00588193980507118 NA NA NA hsa-miR-106a-5p CSF1 -0.203919267842652 0.802213958426804 -0.252531366178799 0.777200619662166 miRNATAP -0.323395441681629 4.18955463178332e-06 NA NA NA hsa-miR-106b-5p CSF1 -0.297128724729339 0.869294443540749 -0.252531366178799 0.777200619662166 miRNATAP -0.608218348053118 5.66934155230753e-15 NA NA NA hsa-miR-128-3p CSF1 -0.442192625156042 0.783886533572187 -0.252531366178799 0.777200619662166 MirTarget -0.260482065672388 0.00495935713439579 22909061 By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR we identified a common target for both miR-128 and miR-152; We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro two major aspects of the metastatic potential of cancer cells; Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1 an important regulator of ovarian cancer motility ovarian cancer hsa-miR-130b-3p CSF1 -0.221667315324818 0.824660172394714 -0.252531366178799 0.777200619662166 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.469017258632817 4.47777835200458e-11 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-148a-3p CSF1 -0.101286586375016 0.976980454193186 -0.252531366178799 0.777200619662166 miRNATAP -0.38027808141193 1.42574348879762e-07 NA NA NA hsa-miR-148b-3p CSF1 -0.202106692287125 0.911884960581838 -0.252531366178799 0.777200619662166 miRNAWalker2_validate -0.331580756020697 0.00151294828294846 NA NA NA hsa-miR-15a-5p CSF1 -0.0674049094129128 0.964835434214123 -0.252531366178799 0.777200619662166 miRNATAP -0.309212803733021 0.000332690214416442 NA NA NA hsa-miR-15b-5p CSF1 -0.272614787130877 0.87096541832188 -0.252531366178799 0.777200619662166 miRNATAP -0.293109396578999 0.000289376414871647 NA NA NA hsa-miR-16-5p CSF1 0.0135949734723564 0.994476223855607 -0.252531366178799 0.777200619662166 miRNATAP -0.392458405549128 8.25923462604606e-07 NA NA NA hsa-miR-17-5p CSF1 -0.175448849583061 0.934544015912731 -0.252531366178799 0.777200619662166 TargetScan;miRNATAP -0.44082146001902 1.620425786916e-13 NA NA NA hsa-miR-20a-5p CSF1 -0.179153323927949 0.928118119139752 -0.252531366178799 0.777200619662166 miRNATAP -0.382513353413265 1.53754034472633e-10 NA NA NA hsa-miR-23a-5p CSF1 -0.697299079757902 0.1188853327314 -0.252531366178799 0.777200619662166 MirTarget -0.132006391764098 0.00436897209843804 NA NA NA hsa-miR-27a-3p CSF1 -0.123902317731458 0.958804393510999 -0.252531366178799 0.777200619662166 MirTarget;miRNATAP -0.369748973744669 0.00128394330593675 NA NA NA hsa-miR-301a-3p CSF1 -0.105312511901769 0.831686745977347 -0.252531366178799 0.777200619662166 MirTarget;miRNATAP -0.282433229783897 4.57168245268115e-06 NA NA NA hsa-miR-30b-5p CSF1 -0.0121430518253582 0.994622896704513 -0.252531366178799 0.777200619662166 miRNAWalker2_validate -0.458638412092148 1.27845700007534e-11 NA NA NA hsa-miR-30c-5p CSF1 -0.298383882401475 0.865809030482001 -0.252531366178799 0.777200619662166 miRNAWalker2_validate -0.474161022421685 1.96369136215612e-06 NA NA NA hsa-miR-335-5p CSF1 -0.0284895175847679 0.973380867832231 -0.252531366178799 0.777200619662166 miRNAWalker2_validate -0.486977097737539 4.29981931496918e-15 NA NA NA hsa-miR-423-5p CSF1 -0.140317642654 0.912448846587903 -0.252531366178799 0.777200619662166 miRNATAP -0.314514296711895 0.000276407128361644 NA NA NA hsa-miR-424-5p CSF1 0.247080963500746 0.870154571783568 -0.252531366178799 0.777200619662166 miRNATAP -0.197377996550209 0.000989167907239471 NA NA NA hsa-miR-429 CSF1 -0.456485631615963 0.806240953400535 -0.252531366178799 0.777200619662166 PITA;miRanda;miRNATAP -0.356022558690501 7.65693302761238e-11 NA NA NA hsa-miR-454-3p CSF1 -0.101514866328011 0.843545158256191 -0.252531366178799 0.777200619662166 MirTarget;miRNATAP -0.506936701110765 1.09802459391483e-09 NA NA NA hsa-miR-505-3p CSF1 -0.469094267152605 0.690382680489578 -0.252531366178799 0.777200619662166 miRNAWalker2_validate -0.368339423119592 1.65823672001737e-05 NA NA NA hsa-miR-532-3p CSF1 -0.496590111092324 0.682889021782543 -0.252531366178799 0.777200619662166 MirTarget;PITA -0.362974372426505 8.1850463876991e-09 NA NA NA hsa-miR-532-5p CSF1 -0.349665553500088 0.878948352437467 -0.252531366178799 0.777200619662166 miRNATAP -0.292494381006082 3.91823087607345e-05 NA NA NA hsa-miR-93-5p CSF1 -0.611073677204699 0.825297877093193 -0.252531366178799 0.777200619662166 miRNATAP -0.452469432502215 2.22815048830137e-09 NA NA NA hsa-miR-939-5p CSF1 -0.311196961912953 0.304447903545905 -0.252531366178799 0.777200619662166 MirTarget -0.270484446518418 1.48952032100827e-05 NA NA NA hsa-miR-940 CSF1 -0.225788347550697 0.680055767105815 -0.252531366178799 0.777200619662166 MirTarget;PITA;miRNATAP -0.239805433420129 2.16547642012011e-06 NA NA NA hsa-miR-96-5p CSF1 0.0854810872029343 0.923087820185031 -0.252531366178799 0.777200619662166 miRNATAP -0.429133319834493 2.4296675097054e-13 NA NA NA hsa-miR-1275 CSF1R -0.831342050607648 0.0803795852164229 -0.28202175069937 0.798643363749792 MirTarget -0.28098420617344 8.4192050908413e-06 NA NA NA hsa-miR-339-5p CSF1R -0.300425087100667 0.712912847076788 -0.28202175069937 0.798643363749792 miRanda -0.566751474398416 8.7294081360447e-13 NA NA NA hsa-miR-34a-5p CSF1R -0.50188164870224 0.742034237185732 -0.28202175069937 0.798643363749792 MirTarget;miRNATAP -0.284183148962691 0.00893929195617197 NA NA NA hsa-miR-30b-3p CSF3R -0.514644352757504 0.162424853398397 -0.471236404125504 0.478352750469895 MirTarget -0.5313140628677 1.80158939385715e-05 NA NA NA hsa-miR-361-5p CSF3R -0.138735309928775 0.941495130308343 -0.471236404125504 0.478352750469895 miRanda -0.618281735002952 0.00471250922014669 NA NA NA hsa-miR-429 CSF3R -0.456485631615963 0.806240953400535 -0.471236404125504 0.478352750469895 miRanda -0.514449210216783 2.67005810481134e-07 NA NA NA hsa-miR-940 CSF3R -0.225788347550697 0.680055767105815 -0.471236404125504 0.478352750469895 MirTarget -0.345115039813433 0.000168588258554028 NA NA NA hsa-miR-101-3p DDIT4 0.0107754887734437 0.997036362636866 0.405899370966925 0.807447906245303 miRNAWalker2_validate;MirTarget;miRNATAP -0.330016470287065 0.000858605408490548 NA NA NA hsa-miR-181d-5p DDIT4 0.14926527647499 0.888000971478017 0.405899370966925 0.807447906245303 MirTarget -0.150726957784208 0.0056584055591032 NA NA NA hsa-miR-217 DDIT4 0.341080669095094 0.760998144794468 0.405899370966925 0.807447906245303 miRanda -0.197615123248097 5.96261128958287e-05 NA NA NA hsa-miR-30c-2-3p EFNA1 0.242912714924037 0.746927269997556 0.261639312685932 0.866820045372497 MirTarget -0.317632550673705 9.802938660626e-08 NA NA NA hsa-miR-9-5p EFNA1 0.447601333076892 0.795015262386155 0.261639312685932 0.866820045372497 miRNAWalker2_validate;miRNATAP -0.102699435989511 0.0018786584099939 NA NA NA hsa-miR-30a-5p EFNA3 0.219472325612346 0.933954023293816 0.318286597903787 0.787986239865054 MirTarget;mirMAP;miRNATAP -0.397827293631223 0.000671423158582254 NA NA NA hsa-let-7a-3p EFNA5 -0.215598045625677 0.85543299203799 0.503344091670042 0.404435726866389 miRNATAP -0.40543498468815 0.00989547054421855 NA NA NA hsa-miR-1275 EFNA5 -0.831342050607648 0.0803795852164229 0.503344091670042 0.404435726866389 mirMAP -0.336952379729342 0.000142905613045414 NA NA NA hsa-miR-144-3p EFNA5 0.0482420655617901 0.935871997593533 0.503344091670042 0.404435726866389 miRNATAP -0.240640043897073 0.00527817303128666 NA NA NA hsa-miR-15b-3p EFNA5 -0.557749208157585 0.609181305423188 0.503344091670042 0.404435726866389 mirMAP -0.636174513488425 9.88897797844726e-06 NA NA NA hsa-miR-186-5p EFNA5 -0.318786974828757 0.85412722938961 0.503344091670042 0.404435726866389 mirMAP -0.686424203917528 0.00053173732928788 NA NA NA hsa-miR-188-3p EFNA5 -0.292769686102066 0.475019668859617 0.503344091670042 0.404435726866389 miRNATAP -0.377651870178639 9.40265990288421e-05 NA NA NA hsa-miR-19a-3p EFNA5 -0.206793507801887 0.844637784802316 0.503344091670042 0.404435726866389 miRNATAP -0.703255106639825 6.85891867099046e-10 NA NA NA hsa-miR-19b-3p EFNA5 -0.0268530183621474 0.986656783046572 0.503344091670042 0.404435726866389 miRNATAP -0.914239459613248 1.357710407562e-11 NA NA NA hsa-miR-200b-3p EFNA5 -0.426401948379212 0.863957108574195 0.503344091670042 0.404435726866389 TargetScan -0.520085660578648 0.000152482558219217 NA NA NA hsa-miR-200c-3p EFNA5 -0.437282635857873 0.887118598436407 0.503344091670042 0.404435726866389 miRNATAP -0.446832966136964 0.00165673178708209 NA NA NA hsa-miR-20a-3p EFNA5 0.456808229166028 0.57674056136504 0.503344091670042 0.404435726866389 mirMAP -0.624232248464653 5.34824307417745e-11 NA NA NA hsa-miR-21-3p EFNA5 -0.395016549347053 0.87819982773565 0.503344091670042 0.404435726866389 mirMAP -0.626482565161211 0.000184113163579591 NA NA NA hsa-miR-26a-2-3p EFNA5 -0.427772454814258 0.28776911697575 0.503344091670042 0.404435726866389 MirTarget -0.399126735290235 0.00178092281587676 NA NA NA hsa-miR-29a-3p EFNA5 0.01127474410284 0.996977020481272 0.503344091670042 0.404435726866389 miRNATAP -0.856917315728278 2.93708194215123e-06 NA NA NA hsa-miR-29b-3p EFNA5 -0.104016192263954 0.958988036765397 0.503344091670042 0.404435726866389 miRNATAP -0.819756027513277 1.97493348943382e-09 NA NA NA hsa-miR-32-3p EFNA5 -0.568003960723004 0.13133163420273 0.503344091670042 0.404435726866389 mirMAP -0.351974953685148 0.000563095148940417 NA NA NA hsa-miR-335-3p EFNA5 -0.244830745789445 0.88450019116631 0.503344091670042 0.404435726866389 mirMAP -0.892967923940506 3.85874646311541e-13 NA NA NA hsa-miR-335-5p EFNA5 -0.0284895175847679 0.973380867832231 0.503344091670042 0.404435726866389 miRNAWalker2_validate -0.632382481020738 6.92545140685037e-07 NA NA NA hsa-miR-362-3p EFNA5 -0.721040238345347 0.0345881362485733 0.503344091670042 0.404435726866389 miRanda -0.430670891465251 0.000168665031366013 NA NA NA hsa-miR-369-3p EFNA5 0.116576891957687 0.83230082995912 0.503344091670042 0.404435726866389 MirTarget;miRNATAP -0.414836438291738 0.004253651551035 NA NA NA hsa-miR-378a-3p EFNA5 -0.466787210598086 0.795055970353024 0.503344091670042 0.404435726866389 miRNATAP -0.449935303931369 0.0041586699064027 NA NA NA hsa-miR-421 EFNA5 -0.182032017078616 0.734704500318599 0.503344091670042 0.404435726866389 mirMAP -0.602549859194601 6.73004723958215e-06 NA NA NA hsa-miR-429 EFNA5 -0.456485631615963 0.806240953400535 0.503344091670042 0.404435726866389 miRNATAP -0.45771503418913 3.67519005401933e-05 NA NA NA hsa-miR-450b-5p EFNA5 -0.0136687538973108 0.983149761399849 0.503344091670042 0.404435726866389 mirMAP -0.438237343684117 0.00298313188299684 NA NA NA hsa-miR-501-5p EFNA5 -0.834032628506285 0.0582725160418523 0.503344091670042 0.404435726866389 mirMAP -0.398453225685377 0.000138428863543361 NA NA NA hsa-miR-542-3p EFNA5 0.188168046511374 0.909252939431573 0.503344091670042 0.404435726866389 miRanda;mirMAP -0.517547865646544 0.00264291637237236 NA NA NA hsa-miR-577 EFNA5 -1.06238199218774 0.326056761787754 0.503344091670042 0.404435726866389 mirMAP -0.285907558216753 9.11226925221999e-05 NA NA NA hsa-miR-590-3p EFNA5 -0.279244755376859 0.59126669933662 0.503344091670042 0.404435726866389 miRanda;mirMAP -0.44147931715964 0.000171151576566218 NA NA NA hsa-miR-592 EFNA5 -0.177670083168544 0.856226890424691 0.503344091670042 0.404435726866389 mirMAP;miRNATAP -0.238609254751356 5.3801465264549e-05 NA NA NA hsa-miR-7-1-3p EFNA5 -0.462485777435991 0.665899751398166 0.503344091670042 0.404435726866389 mirMAP -0.392759658085601 0.00460135451492935 NA NA NA hsa-miR-92a-3p EFNA5 0.0278830870766349 0.993247426671713 0.503344091670042 0.404435726866389 miRNAWalker2_validate -0.916308273683341 6.51205629747335e-11 NA NA NA hsa-miR-96-5p EFNA5 0.0854810872029343 0.923087820185031 0.503344091670042 0.404435726866389 TargetScan -0.342744854452614 0.00479691915332912 NA NA NA hsa-miR-146a-5p EGFR -0.581292803346906 0.73685134936757 -0.158757048599807 0.889536836433204 miRNAWalker2_validate -0.120342498153531 0.00926534743929207 25242818;22161865;25596948;24895573;25417703;23555954;24839931;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;progression;;;;;; pancreatic cancer;prostate cancer;breast cancer;liver cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-148b-5p EGFR -0.236618793990305 0.43925706879726 -0.158757048599807 0.889536836433204 mirMAP -0.146751875727126 0.00334551627619675 NA NA NA hsa-miR-32-3p EGFR -0.568003960723004 0.13133163420273 -0.158757048599807 0.889536836433204 mirMAP -0.127312035684583 0.00126420267436394 NA NA NA hsa-miR-501-5p EGFR -0.834032628506285 0.0582725160418523 -0.158757048599807 0.889536836433204 mirMAP -0.109121341773138 0.00737323655722487 NA NA NA hsa-miR-195-5p EIF4B 0.343201952346823 0.749622318650888 -0.0159402375365101 0.993751060153722 MirTarget;miRNATAP -0.102716243803497 0.0011333910434656 NA NA NA hsa-miR-497-5p EIF4B -0.0120217191428731 0.989147225742026 -0.0159402375365101 0.993751060153722 miRNATAP -0.143049020289145 0.000121468644640018 NA NA NA hsa-miR-130a-3p EIF4E 0.0910074087716906 0.929098200371948 -0.0188557228668431 0.987449694619988 mirMAP -0.124499666759526 0.00106249041500023 NA NA NA hsa-miR-139-5p EIF4E -0.0810891026597322 0.928690377743652 -0.0188557228668431 0.987449694619988 miRanda -0.112199428425707 0.00313716472717178 NA NA NA hsa-miR-145-5p EIF4E 0.0379358609701441 0.987582252034037 -0.0188557228668431 0.987449694619988 miRNAWalker2_validate;miRTarBase -0.127405505660348 7.71222721286519e-05 NA NA NA hsa-miR-29c-3p EIF4E 0.162451700202704 0.942720457512509 -0.0188557228668431 0.987449694619988 mirMAP -0.105127991824042 0.00551185953467407 NA NA NA hsa-miR-30a-3p EIF4E 0.250338313897394 0.917094926793447 -0.0188557228668431 0.987449694619988 mirMAP -0.13405069081027 0.00696291799899749 NA NA NA hsa-miR-485-3p EIF4E -0.078248073031686 0.840126362133974 -0.0188557228668431 0.987449694619988 MirTarget;mirMAP -0.108031007406798 0.000749086773309524 NA NA NA hsa-miR-125b-5p EIF4EBP1 0.042694645848468 0.980586836124662 -0.182459892774385 0.891518183932349 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.140179204025962 0.00143796990077998 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-miR-126-5p F2R 0.0815213541035824 0.956637332055185 -0.18353996658675 0.885264208633463 mirMAP -0.252830698175192 0.00236441525082096 NA NA NA hsa-miR-16-2-3p F2R -0.36717860153421 0.546850726070016 -0.18353996658675 0.885264208633463 mirMAP -0.422816893957661 5.90524505675099e-14 NA NA NA hsa-miR-190a-5p F2R -0.275531208543264 0.538488213403162 -0.18353996658675 0.885264208633463 MirTarget -0.232949636662075 7.21537038272168e-05 NA NA NA hsa-miR-20a-3p F2R 0.456808229166028 0.57674056136504 -0.18353996658675 0.885264208633463 MirTarget -0.288010321712105 3.27233148106949e-11 NA NA NA hsa-miR-23a-3p F2R -0.122198715333656 0.962717452143511 -0.18353996658675 0.885264208633463 MirTarget -0.388016033402894 0.0011951935188831 NA NA NA hsa-miR-29a-5p F2R -0.31835175571979 0.600442757817281 -0.18353996658675 0.885264208633463 MirTarget -0.457821794644742 1.19730486173235e-16 NA NA NA hsa-miR-335-3p F2R -0.244830745789445 0.88450019116631 -0.18353996658675 0.885264208633463 MirTarget -0.294084659421307 3.76624108985646e-07 NA NA NA hsa-miR-361-5p F2R -0.138735309928775 0.941495130308343 -0.18353996658675 0.885264208633463 miRanda -0.377439304203819 0.000547017105902457 NA NA NA hsa-miR-429 F2R -0.456485631615963 0.806240953400535 -0.18353996658675 0.885264208633463 miRanda -0.33104590980734 1.52494713186771e-11 NA NA NA hsa-miR-486-5p F2R -0.547739229538641 0.696404149927963 -0.18353996658675 0.885264208633463 miRanda -0.131761979488426 0.00243399510916119 NA NA NA hsa-miR-491-5p F2R -0.585652105321328 0.0452620602586908 -0.18353996658675 0.885264208633463 miRanda -0.159807460029832 0.00576440004331993 NA NA NA hsa-miR-577 F2R -1.06238199218774 0.326056761787754 -0.18353996658675 0.885264208633463 MirTarget;miRNATAP -0.234958426307983 1.98110478436312e-13 NA NA NA hsa-miR-582-5p F2R -0.399450205475138 0.581227478860085 -0.18353996658675 0.885264208633463 MirTarget -0.303333420476401 1.18326829360685e-05 NA NA NA hsa-miR-589-3p F2R -0.835836305204965 0.0112001563801511 -0.18353996658675 0.885264208633463 MirTarget -0.236646130832539 1.73622377951195e-06 NA NA NA hsa-miR-590-3p F2R -0.279244755376859 0.59126669933662 -0.18353996658675 0.885264208633463 miRanda;mirMAP;miRNATAP -0.380053446040983 1.24363370820044e-13 NA NA NA hsa-miR-590-5p F2R -0.547819833829572 0.472735645776647 -0.18353996658675 0.885264208633463 miRanda -0.482288097011356 4.20004367038359e-20 NA NA NA hsa-miR-452-3p FASLG -0.167134177977311 0.799008246175244 -1.01623663960814 0.0497518030689545 mirMAP -0.300498727144317 0.000506966650214745 NA NA NA hsa-miR-92a-3p FASLG 0.0278830870766349 0.993247426671713 -1.01623663960814 0.0497518030689545 miRNATAP -0.376276337966714 0.00278748481239554 NA NA NA hsa-miR-126-5p FGF1 0.0815213541035824 0.956637332055185 0.817056717165033 0.0360338129925349 mirMAP -0.385963766795316 0.00339122919028115 NA NA NA hsa-miR-1275 FGF1 -0.831342050607648 0.0803795852164229 0.817056717165033 0.0360338129925349 MirTarget -0.234426625474762 0.00025742532980694 NA NA NA hsa-miR-16-1-3p FGF1 0.151694812889216 0.733736501874638 0.817056717165033 0.0360338129925349 mirMAP -0.605586522404409 2.09972410475602e-12 NA NA NA hsa-miR-186-5p FGF1 -0.318786974828757 0.85412722938961 0.817056717165033 0.0360338129925349 mirMAP -1.0155361405459 1.0125599886581e-13 NA NA NA hsa-miR-18a-5p FGF1 -0.498318455303917 0.61264091975585 0.817056717165033 0.0360338129925349 MirTarget -0.60434160371127 3.90449003199202e-18 NA NA NA hsa-miR-18b-5p FGF1 -0.0473300652227538 0.899981261531446 0.817056717165033 0.0360338129925349 MirTarget -0.497414084504357 1.23330693858757e-12 NA NA NA hsa-miR-193a-3p FGF1 -0.247265785363732 0.654363581941634 0.817056717165033 0.0360338129925349 PITA -0.313381826112066 0.00108444554830563 NA NA NA hsa-miR-222-5p FGF1 -0.154611068970282 0.819707762805266 0.817056717165033 0.0360338129925349 MirTarget -0.535437056747217 2.28482793706673e-12 NA NA NA hsa-miR-26b-3p FGF1 -0.363222538866814 0.681115126930068 0.817056717165033 0.0360338129925349 MirTarget -0.734270844592521 3.56140435477727e-13 NA NA NA hsa-miR-29a-5p FGF1 -0.31835175571979 0.600442757817281 0.817056717165033 0.0360338129925349 mirMAP -0.700869123417915 1.6307908971127e-15 NA NA NA hsa-miR-320a FGF1 -0.416546433767628 0.840202138616422 0.817056717165033 0.0360338129925349 miRanda -0.463245151210083 0.000132662825849526 NA NA NA hsa-miR-320b FGF1 -0.23561798088153 0.859222532827992 0.817056717165033 0.0360338129925349 miRanda -0.36919906840847 0.000725718517943916 NA NA NA hsa-miR-361-5p FGF1 -0.138735309928775 0.941495130308343 0.817056717165033 0.0360338129925349 miRanda -0.574545150291662 0.00089792986324362 NA NA NA hsa-miR-374a-3p FGF1 -0.118320910531011 0.958176637009264 0.817056717165033 0.0360338129925349 mirMAP -0.501039740161645 6.25400030648256e-07 NA NA NA hsa-miR-429 FGF1 -0.456485631615963 0.806240953400535 0.817056717165033 0.0360338129925349 miRNATAP -0.672751207199376 2.21205294562789e-19 NA NA NA hsa-miR-484 FGF1 -0.179977202691249 0.886333755572375 0.817056717165033 0.0360338129925349 MirTarget;PITA;miRNATAP -0.854875358873338 2.86755681607907e-12 NA NA NA hsa-miR-532-3p FGF1 -0.496590111092324 0.682889021782543 0.817056717165033 0.0360338129925349 miRNATAP -0.579090993770955 6.93746015430313e-11 NA NA NA hsa-miR-550a-5p FGF1 -0.390865630073894 0.535659273352227 0.817056717165033 0.0360338129925349 MirTarget -0.481202126196725 6.09656439029238e-08 NA NA NA hsa-miR-576-5p FGF1 -0.506413219377403 0.417187951364173 0.817056717165033 0.0360338129925349 PITA;mirMAP -0.746010979431166 1.42643113650642e-14 NA NA NA hsa-miR-590-5p FGF1 -0.547819833829572 0.472735645776647 0.817056717165033 0.0360338129925349 MirTarget;miRanda;miRNATAP -0.763780626727086 3.98618728517647e-20 NA NA NA hsa-miR-625-5p FGF1 -0.690759472145277 0.210306534567564 0.817056717165033 0.0360338129925349 MirTarget -0.489273238427581 1.13468194544974e-11 NA NA NA hsa-miR-629-5p FGF1 -0.385679366494342 0.798536530066869 0.817056717165033 0.0360338129925349 MirTarget -0.496856100338096 7.34270954766289e-08 NA NA NA hsa-miR-7-5p FGF1 0.209645143210379 0.773705612298441 0.817056717165033 0.0360338129925349 miRNAWalker2_validate -0.339779616875168 5.53944074838168e-08 NA NA NA hsa-miR-760 FGF1 -0.669469782471462 0.0773517068284613 0.817056717165033 0.0360338129925349 MirTarget;PITA;miRNATAP -0.303186524946084 1.30784299012347e-05 NA NA NA hsa-miR-10a-5p FGF11 0.0740585720685925 0.983770933356406 -0.0753104644635859 0.828389111628698 mirMAP -0.183447717169761 0.00781424110500811 NA NA NA hsa-miR-335-5p FGF11 -0.0284895175847679 0.973380867832231 -0.0753104644635859 0.828389111628698 miRNAWalker2_validate;mirMAP -0.301314897890468 3.3865427403947e-06 NA NA NA hsa-miR-339-5p FGF11 -0.300425087100667 0.712912847076788 -0.0753104644635859 0.828389111628698 miRanda -0.15266312930966 0.0096720714062192 NA NA NA hsa-miR-532-3p FGF11 -0.496590111092324 0.682889021782543 -0.0753104644635859 0.828389111628698 mirMAP -0.193839089005114 0.00273015557871241 NA NA NA hsa-let-7a-3p FGF12 -0.215598045625677 0.85543299203799 -0.0733567813264719 0.90082041524438 MirTarget -0.31967445902099 0.000591732965496754 NA NA NA hsa-let-7f-1-3p FGF12 -0.31101436822914 0.693407210545374 -0.0733567813264719 0.90082041524438 MirTarget -0.346530348049905 0.00665542231614084 NA NA NA hsa-miR-107 FGF12 -0.0365118169251648 0.988364120226869 -0.0733567813264719 0.90082041524438 miRanda -0.449940214923557 0.00151566453905866 NA NA NA hsa-miR-17-5p FGF12 -0.175448849583061 0.934544015912731 -0.0733567813264719 0.90082041524438 TargetScan -0.312407470418788 1.8707426320976e-05 NA NA NA hsa-miR-197-3p FGF12 -0.455489147957159 0.794916582095149 -0.0733567813264719 0.90082041524438 MirTarget -0.349442074406489 0.000122775742485391 NA NA NA hsa-miR-200b-3p FGF12 -0.426401948379212 0.863957108574195 -0.0733567813264719 0.90082041524438 TargetScan -0.399263932943052 7.91026139011957e-07 NA NA NA hsa-miR-29a-5p FGF12 -0.31835175571979 0.600442757817281 -0.0733567813264719 0.90082041524438 MirTarget -0.419708837882208 2.26602339644268e-08 NA NA NA hsa-miR-32-3p FGF12 -0.568003960723004 0.13133163420273 -0.0733567813264719 0.90082041524438 mirMAP -0.238419633289351 8.17883299774707e-05 NA NA NA hsa-miR-335-3p FGF12 -0.244830745789445 0.88450019116631 -0.0733567813264719 0.90082041524438 MirTarget -0.241577032938532 0.00166504582837203 NA NA NA hsa-miR-33a-3p FGF12 -0.794543849238581 0.0105203072007922 -0.0733567813264719 0.90082041524438 mirMAP -0.28084613962831 7.33431744825372e-05 NA NA NA hsa-miR-362-3p FGF12 -0.721040238345347 0.0345881362485733 -0.0733567813264719 0.90082041524438 miRanda -0.210864640223074 0.00209390425937481 NA NA NA hsa-miR-429 FGF12 -0.456485631615963 0.806240953400535 -0.0733567813264719 0.90082041524438 miRNATAP -0.342286210060465 1.57145983452803e-07 NA NA NA hsa-miR-576-5p FGF12 -0.506413219377403 0.417187951364173 -0.0733567813264719 0.90082041524438 mirMAP -0.341959557719686 4.41549115389718e-05 NA NA NA hsa-miR-590-3p FGF12 -0.279244755376859 0.59126669933662 -0.0733567813264719 0.90082041524438 mirMAP -0.351420488091145 3.56594942426894e-07 NA NA NA hsa-miR-627-5p FGF12 -0.625000196758523 0.0876569242709129 -0.0733567813264719 0.90082041524438 MirTarget -0.248598270695446 1.94113453452336e-05 NA NA NA hsa-let-7a-3p FGF13 -0.215598045625677 0.85543299203799 0.520694054373788 0.23998224203533 MirTarget;miRNATAP -0.413074100574929 0.00107885043966615 NA NA NA hsa-let-7f-1-3p FGF13 -0.31101436822914 0.693407210545374 0.520694054373788 0.23998224203533 MirTarget -0.581948669375274 0.000736238594408478 NA NA NA hsa-let-7g-3p FGF13 -0.489638373791485 0.62941522205833 0.520694054373788 0.23998224203533 miRNATAP -0.33696694896657 0.000531004193754099 NA NA NA hsa-miR-141-3p FGF13 -0.31994058840327 0.87774106909065 0.520694054373788 0.23998224203533 TargetScan -0.417159688034008 1.38167745575151e-05 NA NA NA hsa-miR-142-5p FGF13 -0.118920788314118 0.929665277963083 0.520694054373788 0.23998224203533 PITA -0.292382680960941 0.00456041296807669 NA NA NA hsa-miR-200a-5p FGF13 -0.671005453811576 0.78126028567661 0.520694054373788 0.23998224203533 MirTarget;miRNATAP -0.564495834356228 3.51651879637505e-08 NA NA NA hsa-miR-200b-5p FGF13 -0.502275384207405 0.722255155236927 0.520694054373788 0.23998224203533 MirTarget -0.460602297876751 6.93130489630411e-06 NA NA NA hsa-miR-31-3p FGF13 0.199700996192121 0.762032341762692 0.520694054373788 0.23998224203533 miRNATAP -0.174024666919551 0.000702309408246688 NA NA NA hsa-miR-338-5p FGF13 0.484769112400393 0.393961930708873 0.520694054373788 0.23998224203533 PITA -0.36774029417946 7.03795092005192e-06 NA NA NA hsa-miR-429 FGF13 -0.456485631615963 0.806240953400535 0.520694054373788 0.23998224203533 miRNATAP -0.355487712048412 7.40384400340134e-05 NA NA NA hsa-miR-486-5p FGF13 -0.547739229538641 0.696404149927963 0.520694054373788 0.23998224203533 MirTarget;PITA;miRanda;miRNATAP -0.326993602223932 1.70539866789723e-05 NA NA NA hsa-miR-590-3p FGF13 -0.279244755376859 0.59126669933662 0.520694054373788 0.23998224203533 miRanda -0.459516353830251 9.69022571347246e-07 NA NA NA hsa-miR-7-1-3p FGF13 -0.462485777435991 0.665899751398166 0.520694054373788 0.23998224203533 MirTarget;mirMAP -0.56794497333139 2.1848177002488e-07 NA NA NA hsa-miR-362-3p FGF14 -0.721040238345347 0.0345881362485733 0.374536933825775 0.507146047810317 miRanda -0.430182537519489 0.000218513107489866 NA NA NA hsa-miR-421 FGF14 -0.182032017078616 0.734704500318599 0.374536933825775 0.507146047810317 miRanda -0.563420841003856 3.64961938596398e-05 NA NA NA hsa-miR-590-3p FGF14 -0.279244755376859 0.59126669933662 0.374536933825775 0.507146047810317 miRanda -0.820571422841574 7.63570407372503e-13 NA NA NA hsa-miR-96-5p FGF14 0.0854810872029343 0.923087820185031 0.374536933825775 0.507146047810317 TargetScan -0.651137820954271 6.59629769306502e-08 NA NA NA hsa-miR-107 FGF18 -0.0365118169251648 0.988364120226869 0.513929702717105 0.152144517947723 miRNATAP -0.44685632238394 0.00446346884872776 NA NA NA hsa-miR-15b-5p FGF18 -0.272614787130877 0.87096541832188 0.513929702717105 0.152144517947723 miRNATAP -0.345636147309442 0.00101388588722558 NA NA NA hsa-miR-330-5p FGF18 -0.283418953659271 0.815687101334695 0.513929702717105 0.152144517947723 PITA;miRanda;miRNATAP -0.337702816618645 0.00574604476925169 NA NA NA hsa-miR-590-3p FGF19 -0.279244755376859 0.59126669933662 2.93753615752985 0.000487871953382583 miRanda -0.570350872877377 0.00177520377476347 NA NA NA hsa-let-7a-3p FGF2 -0.215598045625677 0.85543299203799 0.0373403819942291 0.945663156310759 mirMAP -0.508812543963832 9.06476874891136e-06 NA NA NA hsa-let-7f-1-3p FGF2 -0.31101436822914 0.693407210545374 0.0373403819942291 0.945663156310759 mirMAP -0.898041596287031 5.55229359834088e-09 NA NA NA hsa-miR-103a-3p FGF2 -0.0763197091351717 0.980693102700275 0.0373403819942291 0.945663156310759 miRNAWalker2_validate;MirTarget;miRNATAP -0.555487766101954 0.000299387910834376 NA NA NA hsa-miR-107 FGF2 -0.0365118169251648 0.988364120226869 0.0373403819942291 0.945663156310759 MirTarget;PITA;miRanda;miRNATAP -0.666631439624559 0.000145161445434373 NA NA NA hsa-miR-1226-3p FGF2 -0.346825224699346 0.341199987121208 0.0373403819942291 0.945663156310759 MirTarget -0.426739098936905 2.27346551727714e-07 NA NA NA hsa-miR-126-5p FGF2 0.0815213541035824 0.956637332055185 0.0373403819942291 0.945663156310759 mirMAP -0.39861237255362 0.00311441679746807 NA NA NA hsa-miR-144-3p FGF2 0.0482420655617901 0.935871997593533 0.0373403819942291 0.945663156310759 MirTarget -0.185114796915547 0.00371893362650857 NA NA NA hsa-miR-146a-5p FGF2 -0.581292803346906 0.73685134936757 0.0373403819942291 0.945663156310759 mirMAP -0.239303659357824 0.00689738103130393 NA NA NA hsa-miR-148a-5p FGF2 -0.448099743845604 0.748419139652266 0.0373403819942291 0.945663156310759 mirMAP -0.643255342350378 1.37067115832144e-10 NA NA NA hsa-miR-15a-5p FGF2 -0.0674049094129128 0.964835434214123 0.0373403819942291 0.945663156310759 MirTarget;miRNATAP -0.810595460576908 2.34389020257957e-11 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 -0.557749208157585 0.609181305423188 0.0373403819942291 0.945663156310759 mirMAP -0.873695486287884 2.58254499447684e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 -0.272614787130877 0.87096541832188 0.0373403819942291 0.945663156310759 MirTarget;miRNATAP -0.632114726323833 4.74427142629327e-08 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 0.151694812889216 0.733736501874638 0.0373403819942291 0.945663156310759 mirMAP -0.595329456522208 1.85904394592668e-11 NA NA NA hsa-miR-16-2-3p FGF2 -0.36717860153421 0.546850726070016 0.0373403819942291 0.945663156310759 mirMAP -0.676110107115778 1.38872264287738e-13 NA NA NA hsa-miR-16-5p FGF2 0.0135949734723564 0.994476223855607 0.0373403819942291 0.945663156310759 miRNAWalker2_validate;MirTarget;miRNATAP -0.781119741978123 5.08790173078263e-12 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-186-5p FGF2 -0.318786974828757 0.85412722938961 0.0373403819942291 0.945663156310759 miRNAWalker2_validate;mirMAP -1.1396095411898 1.32095654595195e-16 NA NA NA hsa-miR-192-5p FGF2 -0.117345487848223 0.972927287653137 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.660983463822095 1.1746446867625e-17 NA NA NA hsa-miR-19b-1-5p FGF2 -0.0105982583216702 0.988511655226679 0.0373403819942291 0.945663156310759 mirMAP -0.6699845320046 3.36056715432067e-13 NA NA NA hsa-miR-200b-3p FGF2 -0.426401948379212 0.863957108574195 0.0373403819942291 0.945663156310759 mirMAP -0.764037256793823 2.14808621340383e-15 NA NA NA hsa-miR-200c-3p FGF2 -0.437282635857873 0.887118598436407 0.0373403819942291 0.945663156310759 mirMAP -0.707152104708369 2.07242913334904e-12 NA NA NA hsa-miR-20a-3p FGF2 0.456808229166028 0.57674056136504 0.0373403819942291 0.945663156310759 mirMAP -0.565021759285698 1.65191743671975e-16 NA NA NA hsa-miR-21-3p FGF2 -0.395016549347053 0.87819982773565 0.0373403819942291 0.945663156310759 mirMAP -0.525887720334036 2.03384873578629e-05 NA NA NA hsa-miR-215-5p FGF2 -0.142648109361913 0.94480931294964 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.1996191442956 0.000148824005851472 NA NA NA hsa-miR-221-3p FGF2 0.0906940388127513 0.959121118272534 0.0373403819942291 0.945663156310759 mirMAP -0.511851720649979 6.5981563407402e-05 NA NA NA hsa-miR-222-3p FGF2 -0.0265849318772702 0.984005474689108 0.0373403819942291 0.945663156310759 mirMAP -0.553734986991286 1.13582430859507e-06 NA NA NA hsa-miR-29a-5p FGF2 -0.31835175571979 0.600442757817281 0.0373403819942291 0.945663156310759 mirMAP -0.742375002118135 1.13325741058218e-16 NA NA NA hsa-miR-32-5p FGF2 -0.05993267619119 0.952975951594959 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.754687420738596 5.83016327813086e-15 NA NA NA hsa-miR-335-3p FGF2 -0.244830745789445 0.88450019116631 0.0373403819942291 0.945663156310759 mirMAP -0.623112924854523 1.0815869667606e-11 NA NA NA hsa-miR-335-5p FGF2 -0.0284895175847679 0.973380867832231 0.0373403819942291 0.945663156310759 miRNATAP -0.536967962946236 9.06296636807829e-09 NA NA NA hsa-miR-361-5p FGF2 -0.138735309928775 0.941495130308343 0.0373403819942291 0.945663156310759 mirMAP -0.78695237917696 7.1578087398883e-06 NA NA NA hsa-miR-374a-3p FGF2 -0.118320910531011 0.958176637009264 0.0373403819942291 0.945663156310759 mirMAP -0.405589678990389 9.7090927181742e-05 NA NA NA hsa-miR-374a-5p FGF2 -0.343007247142618 0.766921280269271 0.0373403819942291 0.945663156310759 mirMAP -0.615897614224652 3.39071246093852e-05 NA NA NA hsa-miR-374b-5p FGF2 -0.285682091626878 0.83569830479965 0.0373403819942291 0.945663156310759 mirMAP -0.63693950869037 9.22970111909352e-06 NA NA NA hsa-miR-424-5p FGF2 0.247080963500746 0.870154571783568 0.0373403819942291 0.945663156310759 MirTarget;miRNATAP -0.317186554824623 0.000274243410436879 NA NA NA hsa-miR-429 FGF2 -0.456485631615963 0.806240953400535 0.0373403819942291 0.945663156310759 mirMAP -0.659250932855199 1.3145598381986e-17 NA NA NA hsa-miR-450b-5p FGF2 -0.0136687538973108 0.983149761399849 0.0373403819942291 0.945663156310759 mirMAP -0.376394927184003 0.000544626699489289 NA NA NA hsa-miR-452-5p FGF2 -0.0504626418153507 0.973874641360401 0.0373403819942291 0.945663156310759 mirMAP -0.316774722550962 0.00166338629734726 NA NA NA hsa-miR-503-5p FGF2 0.181411121123657 0.766398160421164 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.242112168267636 0.00115555825657166 NA NA NA hsa-miR-548o-3p FGF2 -0.191447572716994 0.517725546183501 0.0373403819942291 0.945663156310759 mirMAP -0.405276201885792 1.87951720405162e-05 NA NA NA hsa-miR-577 FGF2 -1.06238199218774 0.326056761787754 0.0373403819942291 0.945663156310759 mirMAP -0.418499733893086 2.48828015960997e-16 NA NA NA hsa-miR-589-3p FGF2 -0.835836305204965 0.0112001563801511 0.0373403819942291 0.945663156310759 mirMAP -0.469403508103215 2.93831023020729e-09 NA NA NA hsa-miR-590-3p FGF2 -0.279244755376859 0.59126669933662 0.0373403819942291 0.945663156310759 miRanda;mirMAP -0.580439028713546 4.11374953518771e-12 NA NA NA hsa-miR-590-5p FGF2 -0.547819833829572 0.472735645776647 0.0373403819942291 0.945663156310759 miRanda;mirMAP -0.776292987315148 8.39227453533076e-20 NA NA NA hsa-miR-92a-3p FGF2 0.0278830870766349 0.993247426671713 0.0373403819942291 0.945663156310759 miRNAWalker2_validate -0.727257700170323 1.67908806653227e-12 NA NA NA hsa-miR-93-3p FGF2 -0.438355548962673 0.549902689385444 0.0373403819942291 0.945663156310759 mirMAP -0.765339743128867 1.06748038330992e-15 NA NA NA hsa-let-7a-3p FGF7 -0.215598045625677 0.85543299203799 0.117105484614997 0.84810083077581 MirTarget;miRNATAP -0.683797140192053 9.84850919759302e-09 NA NA NA hsa-let-7f-1-3p FGF7 -0.31101436822914 0.693407210545374 0.117105484614997 0.84810083077581 MirTarget -1.01161889577803 3.96642337308699e-10 NA NA NA hsa-miR-107 FGF7 -0.0365118169251648 0.988364120226869 0.117105484614997 0.84810083077581 PITA;miRanda;miRNATAP -0.735310081307788 7.03519067269405e-05 NA NA NA hsa-miR-15a-5p FGF7 -0.0674049094129128 0.964835434214123 0.117105484614997 0.84810083077581 miRTarBase;miRNATAP -0.915215726654164 5.87256834931938e-13 NA NA NA hsa-miR-15b-5p FGF7 -0.272614787130877 0.87096541832188 0.117105484614997 0.84810083077581 miRNATAP -0.898118902123496 3.56849030030929e-14 NA NA NA hsa-miR-16-1-3p FGF7 0.151694812889216 0.733736501874638 0.117105484614997 0.84810083077581 mirMAP -0.658002745075143 1.56217551778173e-12 NA NA NA hsa-miR-16-2-3p FGF7 -0.36717860153421 0.546850726070016 0.117105484614997 0.84810083077581 mirMAP -0.841611831563134 3.02322699081552e-19 NA NA NA hsa-miR-16-5p FGF7 0.0135949734723564 0.994476223855607 0.117105484614997 0.84810083077581 miRNATAP -0.996043180010876 9.83296454189259e-18 NA NA NA hsa-miR-18a-3p FGF7 -0.270443061178857 0.535291623032886 0.117105484614997 0.84810083077581 MirTarget -0.452090132240855 7.63312718888582e-09 NA NA NA hsa-miR-192-3p FGF7 -0.182835023264086 0.910241598161436 0.117105484614997 0.84810083077581 mirMAP -0.730591279287558 7.23835865583408e-16 NA NA NA hsa-miR-20a-5p FGF7 -0.179153323927949 0.928118119139752 0.117105484614997 0.84810083077581 miRNAWalker2_validate -0.671805814937027 1.227742024366e-13 NA NA NA hsa-miR-26b-5p FGF7 -0.0245931278499594 0.990377966314923 0.117105484614997 0.84810083077581 mirMAP -0.994759587889311 1.98671841899925e-12 NA NA NA hsa-miR-27a-3p FGF7 -0.123902317731458 0.958804393510999 0.117105484614997 0.84810083077581 MirTarget -0.79784830342047 5.00354716971529e-06 NA NA NA hsa-miR-30d-3p FGF7 -0.123474741320298 0.814905367625791 0.117105484614997 0.84810083077581 miRNATAP -0.848677643180664 4.97187104853254e-13 NA NA NA hsa-miR-31-5p FGF7 0.554749187802405 0.452741448126019 0.117105484614997 0.84810083077581 MirTarget -0.12713264127766 0.00816156313575643 NA NA NA hsa-miR-320a FGF7 -0.416546433767628 0.840202138616422 0.117105484614997 0.84810083077581 miRanda -0.38477547966865 0.00354239940076227 NA NA NA hsa-miR-33a-3p FGF7 -0.794543849238581 0.0105203072007922 0.117105484614997 0.84810083077581 mirMAP -0.569137001117195 3.2142782858291e-10 NA NA NA hsa-miR-361-5p FGF7 -0.138735309928775 0.941495130308343 0.117105484614997 0.84810083077581 PITA;miRanda;miRNATAP -0.817249024356749 1.02535422069167e-05 NA NA NA hsa-miR-374a-3p FGF7 -0.118320910531011 0.958176637009264 0.117105484614997 0.84810083077581 miRNATAP -0.461888146139023 2.48354867802797e-05 NA NA NA hsa-miR-376b-3p FGF7 -0.00712550627858333 0.982426403308526 0.117105484614997 0.84810083077581 mirMAP -0.25669480427003 0.00740387863393709 NA NA NA hsa-miR-421 FGF7 -0.182032017078616 0.734704500318599 0.117105484614997 0.84810083077581 miRanda -0.482726608710923 3.82945596931546e-06 NA NA NA hsa-miR-424-5p FGF7 0.247080963500746 0.870154571783568 0.117105484614997 0.84810083077581 miRNATAP -0.323271584602368 0.000450740900959982 NA NA NA hsa-miR-429 FGF7 -0.456485631615963 0.806240953400535 0.117105484614997 0.84810083077581 miRNATAP -0.774285251391027 2.36438990639667e-22 NA NA NA hsa-miR-455-3p FGF7 -0.356341681711462 0.824635754440661 0.117105484614997 0.84810083077581 PITA;miRNATAP -0.48338226161898 1.06435583592578e-07 NA NA NA hsa-miR-484 FGF7 -0.179977202691249 0.886333755572375 0.117105484614997 0.84810083077581 PITA -0.782625541153355 5.9522288202395e-09 NA NA NA hsa-miR-501-5p FGF7 -0.834032628506285 0.0582725160418523 0.117105484614997 0.84810083077581 PITA;mirMAP -0.341715472671014 2.71246634460809e-05 NA NA NA hsa-miR-577 FGF7 -1.06238199218774 0.326056761787754 0.117105484614997 0.84810083077581 PITA;mirMAP -0.491874797413476 1.17833120646792e-20 NA NA NA hsa-miR-582-3p FGF7 -0.2334649592375 0.897678119160318 0.117105484614997 0.84810083077581 PITA;miRNATAP -0.603474572580205 9.9286156151158e-08 NA NA NA hsa-miR-590-3p FGF7 -0.279244755376859 0.59126669933662 0.117105484614997 0.84810083077581 PITA;miRanda;mirMAP;miRNATAP -0.749830093913929 2.12386794213734e-18 NA NA NA hsa-miR-590-5p FGF7 -0.547819833829572 0.472735645776647 0.117105484614997 0.84810083077581 PITA;miRanda -0.83329719340048 1.49190340527621e-20 NA NA NA hsa-miR-7-1-3p FGF7 -0.462485777435991 0.665899751398166 0.117105484614997 0.84810083077581 mirMAP -0.8693351687903 5.61446758918235e-18 NA NA NA hsa-miR-16-2-3p FGF9 -0.36717860153421 0.546850726070016 1.14029297978378 0.0641126010099636 mirMAP -0.393378730749977 0.00280520232673893 NA NA NA hsa-miR-32-3p FGF9 -0.568003960723004 0.13133163420273 1.14029297978378 0.0641126010099636 mirMAP -0.350559608669684 0.000700563991493217 NA NA NA hsa-miR-369-3p FGF9 0.116576891957687 0.83230082995912 1.14029297978378 0.0641126010099636 mirMAP;miRNATAP -0.385648033163106 0.00880290404065266 NA NA NA hsa-miR-582-5p FGF9 -0.399450205475138 0.581227478860085 1.14029297978378 0.0641126010099636 miRNATAP -0.404187233255667 0.00944896090587376 NA NA NA hsa-miR-590-3p FGF9 -0.279244755376859 0.59126669933662 1.14029297978378 0.0641126010099636 miRanda;mirMAP -0.395821562370221 0.000917959517750086 NA NA NA hsa-miR-590-5p FGF9 -0.547819833829572 0.472735645776647 1.14029297978378 0.0641126010099636 miRanda -0.412960170102671 0.00107892101454606 NA NA NA hsa-miR-106a-5p FGFR1 -0.203919267842652 0.802213958426804 0.201596157808259 0.858976102109112 mirMAP -0.541320037319434 1.27089321486615e-11 NA NA NA hsa-miR-106b-5p FGFR1 -0.297128724729339 0.869294443540749 0.201596157808259 0.858976102109112 mirMAP -0.822036581006192 1.74218158243198e-20 NA NA NA hsa-miR-10a-5p FGFR1 0.0740585720685925 0.983770933356406 0.201596157808259 0.858976102109112 miRNAWalker2_validate -0.427574241021871 5.41836198534693e-08 21738581 Predicted target mRNAs FGFR1 miR-10 and MLH1 miR-155 were found downregulated pancreatic cancer hsa-miR-1262 FGFR1 -0.110067426706709 0.702946442225154 0.201596157808259 0.858976102109112 miRNATAP -0.251289067000032 0.00148412321886111 NA NA NA hsa-miR-135b-5p FGFR1 0.631573976263484 0.610028066417462 0.201596157808259 0.858976102109112 mirMAP -0.282955130702862 1.46105054047634e-08 NA NA NA hsa-miR-15a-5p FGFR1 -0.0674049094129128 0.964835434214123 0.201596157808259 0.858976102109112 miRNATAP -0.697884650841183 4.50635824486199e-13 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 -0.272614787130877 0.87096541832188 0.201596157808259 0.858976102109112 miRNATAP -0.587016769958609 1.49522035399957e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.0135949734723564 0.994476223855607 0.201596157808259 0.858976102109112 miRTarBase;miRNATAP -0.710035294277253 1.6547310603001e-15 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 -0.175448849583061 0.934544015912731 0.201596157808259 0.858976102109112 mirMAP -0.610985080987738 2.23569876237106e-19 NA NA NA hsa-miR-200a-5p FGFR1 -0.671005453811576 0.78126028567661 0.201596157808259 0.858976102109112 mirMAP -0.556564764968645 2.34312674404821e-14 NA NA NA hsa-miR-200b-5p FGFR1 -0.502275384207405 0.722255155236927 0.201596157808259 0.858976102109112 mirMAP -0.636495015609043 1.43412507645059e-19 NA NA NA hsa-miR-20a-5p FGFR1 -0.179153323927949 0.928118119139752 0.201596157808259 0.858976102109112 mirMAP -0.548264098344271 7.83526634355048e-16 NA NA NA hsa-miR-301a-3p FGFR1 -0.105312511901769 0.831686745977347 0.201596157808259 0.858976102109112 mirMAP -0.315204588952987 1.26823479410232e-05 NA NA NA hsa-miR-335-3p FGFR1 -0.244830745789445 0.88450019116631 0.201596157808259 0.858976102109112 mirMAP -0.575295661556483 1.48474905901463e-15 NA NA NA hsa-miR-361-5p FGFR1 -0.138735309928775 0.941495130308343 0.201596157808259 0.858976102109112 miRanda -0.700504879479453 5.36006547735018e-07 NA NA NA hsa-miR-424-5p FGFR1 0.247080963500746 0.870154571783568 0.201596157808259 0.858976102109112 miRNAWalker2_validate;miRTarBase;miRNATAP -0.209822150049386 0.00280762955990033 NA NA NA hsa-miR-532-5p FGFR1 -0.349665553500088 0.878948352437467 0.201596157808259 0.858976102109112 PITA -0.594965040936966 7.97089485362319e-14 NA NA NA hsa-miR-548o-3p FGFR1 -0.191447572716994 0.517725546183501 0.201596157808259 0.858976102109112 mirMAP -0.315700053957701 3.27962049891296e-05 NA NA NA hsa-miR-577 FGFR1 -1.06238199218774 0.326056761787754 0.201596157808259 0.858976102109112 PITA;mirMAP -0.325574779163253 2.46595601408019e-15 NA NA NA hsa-miR-590-3p FGFR1 -0.279244755376859 0.59126669933662 0.201596157808259 0.858976102109112 miRanda;mirMAP -0.519217394538685 4.04575525965042e-15 NA NA NA hsa-miR-93-5p FGFR1 -0.611073677204699 0.825297877093193 0.201596157808259 0.858976102109112 mirMAP -0.666292245954266 1.03850684119196e-14 NA NA NA hsa-miR-188-5p FGFR2 -0.568517670542551 0.324820848307954 -0.37581671975967 0.688774968722175 PITA -0.411925402857108 4.09722691497335e-06 NA NA NA hsa-miR-19b-1-5p FGFR2 -0.0105982583216702 0.988511655226679 -0.37581671975967 0.688774968722175 miRNAWalker2_validate;miRTarBase -0.474383008962662 2.29712590167021e-05 NA NA NA hsa-miR-369-3p FGFR2 0.116576891957687 0.83230082995912 -0.37581671975967 0.688774968722175 miRNATAP -0.32556688552856 0.00975076567041639 NA NA NA hsa-miR-542-3p FGFR2 0.188168046511374 0.909252939431573 -0.37581671975967 0.688774968722175 miRanda -0.720387475259984 9.01022691363113e-07 NA NA NA hsa-miR-940 FGFR2 -0.225788347550697 0.680055767105815 -0.37581671975967 0.688774968722175 miRNATAP -0.270065978012755 0.00207802989445929 NA NA NA hsa-miR-106a-5p FLT1 -0.203919267842652 0.802213958426804 0.335459881337518 0.769646686410767 MirTarget;miRNATAP -0.217932050508775 7.42586014642432e-05 NA NA NA hsa-miR-106b-5p FLT1 -0.297128724729339 0.869294443540749 0.335459881337518 0.769646686410767 MirTarget;miRNATAP -0.362342015309591 6.44034105699633e-09 NA NA NA hsa-miR-10a-5p FLT1 0.0740585720685925 0.983770933356406 0.335459881337518 0.769646686410767 miRNATAP -0.188059072473371 0.000422135661220862 NA NA NA hsa-miR-149-5p FLT1 -0.0341785025317569 0.961061088204977 0.335459881337518 0.769646686410767 MirTarget -0.157900287345921 0.000368536021817626 NA NA NA hsa-miR-17-5p FLT1 -0.175448849583061 0.934544015912731 0.335459881337518 0.769646686410767 MirTarget;TargetScan;miRNATAP -0.232312640570346 1.37730704537759e-06 NA NA NA hsa-miR-181b-5p FLT1 0.155313039554487 0.930176779696506 0.335459881337518 0.769646686410767 miRNATAP -0.187653050926259 0.0044509288988792 NA NA NA hsa-miR-186-5p FLT1 -0.318786974828757 0.85412722938961 0.335459881337518 0.769646686410767 mirMAP -0.270733774321563 0.000537584221831587 NA NA NA hsa-miR-19a-3p FLT1 -0.206793507801887 0.844637784802316 0.335459881337518 0.769646686410767 MirTarget -0.190391787064455 3.58230909213624e-05 NA NA NA hsa-miR-19b-3p FLT1 -0.0268530183621474 0.986656783046572 0.335459881337518 0.769646686410767 MirTarget -0.223701499996085 4.97311863992031e-05 NA NA NA hsa-miR-200b-3p FLT1 -0.426401948379212 0.863957108574195 0.335459881337518 0.769646686410767 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.266841639122542 6.33604980248532e-07 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-200c-3p FLT1 -0.437282635857873 0.887118598436407 0.335459881337518 0.769646686410767 miRNAWalker2_validate;miRTarBase;MirTarget -0.228126738051025 4.1207149994109e-05 NA NA NA hsa-miR-20a-5p FLT1 -0.179153323927949 0.928118119139752 0.335459881337518 0.769646686410767 MirTarget;miRNATAP -0.184216066996964 0.00011858416873161 NA NA NA hsa-miR-24-3p FLT1 -0.0484778924256624 0.985274054814493 0.335459881337518 0.769646686410767 miRNATAP -0.369737504231116 0.000985929131493309 NA NA NA hsa-miR-29a-5p FLT1 -0.31835175571979 0.600442757817281 0.335459881337518 0.769646686410767 MirTarget -0.25426638977066 3.81343086893255e-07 NA NA NA hsa-miR-335-3p FLT1 -0.244830745789445 0.88450019116631 0.335459881337518 0.769646686410767 mirMAP -0.19625230682989 0.000106198318564869 NA NA NA hsa-miR-339-5p FLT1 -0.300425087100667 0.712912847076788 0.335459881337518 0.769646686410767 miRanda -0.311508333463944 1.01479232416928e-12 NA NA NA hsa-miR-369-3p FLT1 0.116576891957687 0.83230082995912 0.335459881337518 0.769646686410767 MirTarget;miRNATAP -0.185436249137413 0.00117046477437708 NA NA NA hsa-miR-429 FLT1 -0.456485631615963 0.806240953400535 0.335459881337518 0.769646686410767 MirTarget;miRanda;miRNATAP -0.239587491657242 2.72032013728119e-08 NA NA NA hsa-miR-491-3p FLT1 -0.513850326596847 0.137836285146052 0.335459881337518 0.769646686410767 miRNATAP -0.177120471645147 0.000140749730219656 NA NA NA hsa-miR-501-5p FLT1 -0.834032628506285 0.0582725160418523 0.335459881337518 0.769646686410767 mirMAP -0.160650412318997 9.80457640413844e-05 NA NA NA hsa-miR-505-5p FLT1 -0.555858818875454 0.317679205488749 0.335459881337518 0.769646686410767 MirTarget -0.171852611824984 0.00192107890591474 NA NA NA hsa-miR-576-5p FLT1 -0.506413219377403 0.417187951364173 0.335459881337518 0.769646686410767 mirMAP -0.178014369696481 0.00145222641220755 NA NA NA hsa-miR-590-3p FLT1 -0.279244755376859 0.59126669933662 0.335459881337518 0.769646686410767 miRanda -0.268266566181388 3.15956947898578e-09 NA NA NA hsa-miR-629-3p FLT1 -0.495402745812008 0.333967382214384 0.335459881337518 0.769646686410767 MirTarget -0.201236032594846 5.44570231226212e-06 NA NA NA hsa-miR-93-5p FLT1 -0.611073677204699 0.825297877093193 0.335459881337518 0.769646686410767 MirTarget;miRNATAP -0.288708238581385 1.30917423548279e-06 NA NA NA hsa-miR-335-5p FLT3 -0.0284895175847679 0.973380867832231 -0.582760672328199 0.454037354535359 miRNAWalker2_validate -0.559024463620852 2.59362128018203e-06 NA NA NA hsa-miR-590-3p FLT3 -0.279244755376859 0.59126669933662 -0.582760672328199 0.454037354535359 PITA;miRanda;mirMAP;miRNATAP -0.397131408453822 0.0002854017762368 NA NA NA hsa-miR-194-3p FLT4 -0.614465699221301 0.733214497063146 0.429953978262657 0.515812907628149 mirMAP -0.438107995800777 7.41811467585558e-14 NA NA NA hsa-miR-331-3p FLT4 -0.40204226129616 0.670588911553669 0.429953978262657 0.515812907628149 miRNAWalker2_validate -0.401841710981882 3.49815729282156e-07 NA NA NA hsa-miR-374a-5p FLT4 -0.343007247142618 0.766921280269271 0.429953978262657 0.515812907628149 mirMAP -0.385992088793107 0.000289488700189213 NA NA NA hsa-miR-374b-5p FLT4 -0.285682091626878 0.83569830479965 0.429953978262657 0.515812907628149 mirMAP -0.522619192236735 2.77352074366153e-07 NA NA NA hsa-miR-429 FLT4 -0.456485631615963 0.806240953400535 0.429953978262657 0.515812907628149 miRanda;miRNATAP -0.416385057079148 1.21614490885909e-13 NA NA NA hsa-let-7g-5p FN1 -0.200947212961157 0.922992045181955 0.677683774609143 0.765794039459135 miRTarBase -1.34746451759445 6.90501376146443e-12 NA NA NA hsa-miR-144-3p FN1 0.0482420655617901 0.935871997593533 0.677683774609143 0.765794039459135 MirTarget -0.356642692589333 5.29526702047798e-06 NA NA NA hsa-miR-16-1-3p FN1 0.151694812889216 0.733736501874638 0.677683774609143 0.765794039459135 mirMAP -0.564237183554045 5.72239347170428e-07 NA NA NA hsa-miR-200b-3p FN1 -0.426401948379212 0.863957108574195 0.677683774609143 0.765794039459135 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.961856135926933 9.2538383385326e-16 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 -0.437282635857873 0.887118598436407 0.677683774609143 0.765794039459135 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.910028114795152 2.93243403007106e-13 NA NA NA hsa-miR-26b-5p FN1 -0.0245931278499594 0.990377966314923 0.677683774609143 0.765794039459135 miRNAWalker2_validate -1.18500572658731 1.10011182878386e-12 NA NA NA hsa-miR-27a-3p FN1 -0.123902317731458 0.958804393510999 0.677683774609143 0.765794039459135 MirTarget -0.577410274769463 0.0057761363935074 NA NA NA hsa-miR-27a-5p FN1 -0.199569428508425 0.850152045732979 0.677683774609143 0.765794039459135 MirTarget -0.345132760584756 0.00208685019732168 NA NA NA hsa-miR-27b-3p FN1 -0.14277121795778 0.951937409841932 0.677683774609143 0.765794039459135 MirTarget -0.78785987615705 0.00100442274557098 NA NA NA hsa-miR-320a FN1 -0.416546433767628 0.840202138616422 0.677683774609143 0.765794039459135 miRanda -0.487586323603894 0.00169442079903532 NA NA NA hsa-miR-33a-3p FN1 -0.794543849238581 0.0105203072007922 0.677683774609143 0.765794039459135 mirMAP -0.626870699017676 5.25973836081997e-09 NA NA NA hsa-miR-429 FN1 -0.456485631615963 0.806240953400535 0.677683774609143 0.765794039459135 MirTarget;PITA;miRanda;miRNATAP -0.784035417720343 5.71185615937179e-16 NA NA NA hsa-miR-590-3p FN1 -0.279244755376859 0.59126669933662 0.677683774609143 0.765794039459135 miRanda;mirMAP -0.812131517257055 2.40437777725866e-15 NA NA NA hsa-miR-96-5p FN1 0.0854810872029343 0.923087820185031 0.677683774609143 0.765794039459135 MirTarget;TargetScan -0.673056323548163 4.91783033053465e-10 NA NA NA hsa-miR-107 FOXO3 -0.0365118169251648 0.988364120226869 -0.0443411187815119 0.975886347887311 miRanda;mirMAP -0.256003877638066 0.000338502454647472 NA NA NA hsa-miR-132-3p FOXO3 -0.244143673573889 0.871752726220643 -0.0443411187815119 0.975886347887311 miRNATAP -0.269418775077881 3.23234846398086e-05 NA NA NA hsa-miR-155-5p FOXO3 -0.407235807706004 0.828669616718496 -0.0443411187815119 0.975886347887311 miRNAWalker2_validate;miRTarBase -0.14130550077605 0.000735911240838006 27596294;25480585;20371610;26398931;22027557;27107135 MiR-155 targets 3´UTR region of multiple components of the pro-oncogenic signaling cascades including FOXO3a tumor suppressor and RUNX2 transcription factor regulating metastatic potential in BC;The effect of miRNA155 on FOXO3a expression was examined by Western blotting; FOXO3a was found to be a possible target of miRNA155 as suggested by Targetscan website;MicroRNA 155 regulates cell survival growth and chemosensitivity by targeting FOXO3a in breast cancer; In this study we demonstrate the critical role of miR-155 in regulation of cell survival and chemosensitivity through down-regulation of FOXO3a in breast cancer; Further we identified FOXO3a as a direct target of miR-155; Sustained overexpression of miR-155 resulted in repression of FOXO3a protein without changing mRNA levels and knockdown of miR-155 increases FOXO3a; Finally inverse correlation between miR-155 and FOXO3a levels were observed in a panel of breast cancer cell lines and tumors; In conclusion our study reveals a molecular link between miR-155 and FOXO3a and presents evidence that miR-155 is a critical therapeutic target in breast cancer;In contrast downregulation of miR-155-5p increased sensitivity to bufalin and upregulated the expression of FOXO3A;Here we show that hypoxic conditions induce miR-155 expression in lung cancer cells and trigger a corresponding decrease in a validated target FOXO3A;Our results further revealed that forkhead box O3a FoxO3a was a miR-155 target in the heart; And miR-155 directly repressed FoxO3a whose expression was mitigated in miR-155 agomir and mimic treatment in vivo and in vitro ;;poor survival;;; breast cancer;lymphoma;breast cancer;breast cancer;lung cancer;breast cancer hsa-miR-212-3p FOXO3 -0.0224067199236484 0.973232008101458 -0.0443411187815119 0.975886347887311 miRNATAP -0.174217478240522 0.00091139636104319 NA NA NA hsa-miR-576-5p FOXO3 -0.506413219377403 0.417187951364173 -0.0443411187815119 0.975886347887311 mirMAP -0.137712980073764 0.00122231501709477 NA NA NA hsa-miR-582-3p FOXO3 -0.2334649592375 0.897678119160318 -0.0443411187815119 0.975886347887311 PITA;miRNATAP -0.175391150287109 7.29086218202542e-05 NA NA NA hsa-miR-92b-3p FOXO3 -0.569866984318692 0.689321861489779 -0.0443411187815119 0.975886347887311 mirMAP -0.191898254055173 1.88378914953521e-06 NA NA NA hsa-let-7f-5p GHR 0.048789917034723 0.987280455481631 0.570638667569632 0.245024953773014 miRNATAP -0.550957043817317 0.00307995104158157 NA NA NA hsa-let-7g-5p GHR -0.200947212961157 0.922992045181955 0.570638667569632 0.245024953773014 miRNATAP -0.548129375387392 0.00375308103747239 NA NA NA hsa-miR-142-3p GHR -0.154235241441331 0.946098054588918 0.570638667569632 0.245024953773014 MirTarget;PITA;miRanda;miRNATAP -0.25845608963523 0.00874573277743459 NA NA NA hsa-miR-15a-5p GHR -0.0674049094129128 0.964835434214123 0.570638667569632 0.245024953773014 MirTarget;miRNATAP -0.771410096762057 5.05122129996976e-08 NA NA NA hsa-miR-15b-5p GHR -0.272614787130877 0.87096541832188 0.570638667569632 0.245024953773014 MirTarget;miRNATAP -0.867389448225228 3.31080514273422e-11 NA NA NA hsa-miR-16-2-3p GHR -0.36717860153421 0.546850726070016 0.570638667569632 0.245024953773014 mirMAP -0.611850858331784 1.27046878075512e-08 NA NA NA hsa-miR-16-5p GHR 0.0135949734723564 0.994476223855607 0.570638667569632 0.245024953773014 MirTarget;miRNATAP -0.8072370172485 7.84861031393396e-10 NA NA NA hsa-miR-29a-5p GHR -0.31835175571979 0.600442757817281 0.570638667569632 0.245024953773014 mirMAP;miRNATAP -0.413065589121629 0.0001546034228248 NA NA NA hsa-miR-33a-3p GHR -0.794543849238581 0.0105203072007922 0.570638667569632 0.245024953773014 miRNATAP -0.350374540395823 0.000555682054497104 NA NA NA hsa-miR-429 GHR -0.456485631615963 0.806240953400535 0.570638667569632 0.245024953773014 miRanda;miRNATAP -0.385654617034442 4.28729865433817e-05 NA NA NA hsa-miR-590-3p GHR -0.279244755376859 0.59126669933662 0.570638667569632 0.245024953773014 mirMAP -0.659886137629109 6.90155909931775e-12 NA NA NA hsa-miR-624-5p GHR -0.348001560408561 0.190596385087429 0.570638667569632 0.245024953773014 MirTarget -0.393085612074636 0.00108743183258024 NA NA NA hsa-miR-7-1-3p GHR -0.462485777435991 0.665899751398166 0.570638667569632 0.245024953773014 MirTarget;mirMAP -0.694008690868991 1.13461523739526e-09 NA NA NA hsa-let-7a-3p GNB4 -0.215598045625677 0.85543299203799 0.150575910970852 0.870906281992549 MirTarget -0.527462288702162 1.32800230080668e-10 NA NA NA hsa-let-7f-1-3p GNB4 -0.31101436822914 0.693407210545374 0.150575910970852 0.870906281992549 MirTarget -0.725850164098216 9.21270487377611e-11 NA NA NA hsa-miR-126-5p GNB4 0.0815213541035824 0.956637332055185 0.150575910970852 0.870906281992549 mirMAP -0.296092228762981 0.00275698662241744 NA NA NA hsa-miR-1275 GNB4 -0.831342050607648 0.0803795852164229 0.150575910970852 0.870906281992549 MirTarget -0.256794511297655 5.71810884593168e-08 NA NA NA hsa-miR-16-2-3p GNB4 -0.36717860153421 0.546850726070016 0.150575910970852 0.870906281992549 mirMAP -0.551716333089633 6.00467816630765e-17 NA NA NA hsa-miR-186-5p GNB4 -0.318786974828757 0.85412722938961 0.150575910970852 0.870906281992549 MirTarget -0.689383409225049 3.1268492590221e-11 NA NA NA hsa-miR-203a-3p GNB4 -0.265248086637561 0.931593594361942 0.150575910970852 0.870906281992549 MirTarget -0.372281855373237 1.22670796920165e-11 NA NA NA hsa-miR-21-3p GNB4 -0.395016549347053 0.87819982773565 0.150575910970852 0.870906281992549 MirTarget -0.427995528370939 2.0332855968286e-06 NA NA NA hsa-miR-23a-3p GNB4 -0.122198715333656 0.962717452143511 0.150575910970852 0.870906281992549 mirMAP -0.472738699668562 0.000893155145884879 NA NA NA hsa-miR-27b-3p GNB4 -0.14277121795778 0.951937409841932 0.150575910970852 0.870906281992549 miRNAWalker2_validate -0.435880720226156 0.00204920933249677 NA NA NA hsa-miR-29a-3p GNB4 0.01127474410284 0.996977020481272 0.150575910970852 0.870906281992549 MirTarget -0.743368974633575 6.34983117847608e-15 NA NA NA hsa-miR-29b-3p GNB4 -0.104016192263954 0.958988036765397 0.150575910970852 0.870906281992549 MirTarget -0.61243623995895 7.63823968895368e-18 NA NA NA hsa-miR-33a-3p GNB4 -0.794543849238581 0.0105203072007922 0.150575910970852 0.870906281992549 MirTarget -0.403517140225735 1.29024852258078e-10 NA NA NA hsa-miR-361-5p GNB4 -0.138735309928775 0.941495130308343 0.150575910970852 0.870906281992549 miRanda;miRNATAP -0.571025704918098 9.11850229661736e-06 NA NA NA hsa-miR-376a-5p GNB4 0.0978680856849549 0.773217338913054 0.150575910970852 0.870906281992549 MirTarget -0.231791319804353 0.000534543494369469 NA NA NA hsa-miR-429 GNB4 -0.456485631615963 0.806240953400535 0.150575910970852 0.870906281992549 miRanda -0.521698904248221 8.01914817356433e-21 NA NA NA hsa-miR-452-5p GNB4 -0.0504626418153507 0.973874641360401 0.150575910970852 0.870906281992549 MirTarget -0.254078324559164 0.00057043017429811 NA NA NA hsa-miR-501-5p GNB4 -0.834032628506285 0.0582725160418523 0.150575910970852 0.870906281992549 mirMAP -0.259427355324393 4.16228772969499e-06 NA NA NA hsa-miR-548o-3p GNB4 -0.191447572716994 0.517725546183501 0.150575910970852 0.870906281992549 MirTarget -0.255354766069344 0.000258360441062798 NA NA NA hsa-miR-582-5p GNB4 -0.399450205475138 0.581227478860085 0.150575910970852 0.870906281992549 MirTarget -0.304596682684376 0.00023676420891946 NA NA NA hsa-miR-590-3p GNB4 -0.279244755376859 0.59126669933662 0.150575910970852 0.870906281992549 MirTarget;miRanda -0.481731712009225 1.49322647046165e-15 NA NA NA hsa-miR-7-1-3p GNB4 -0.462485777435991 0.665899751398166 0.150575910970852 0.870906281992549 MirTarget -0.488446835457065 1.29243217525554e-11 NA NA NA hsa-miR-877-5p GNB4 -0.317720731672575 0.435952264022643 0.150575910970852 0.870906281992549 MirTarget -0.275485690829795 5.55278046948466e-07 NA NA NA hsa-miR-93-5p GNB4 -0.611073677204699 0.825297877093193 0.150575910970852 0.870906281992549 miRNAWalker2_validate -0.570655068620063 7.46595886693956e-13 NA NA NA hsa-miR-96-5p GNB4 0.0854810872029343 0.923087820185031 0.150575910970852 0.870906281992549 MirTarget -0.508627119875564 1.77027482987553e-16 NA NA NA hsa-miR-128-3p GNB5 -0.442192625156042 0.783886533572187 -0.0649528135314408 0.938218455897553 miRNAWalker2_validate -0.275817735059449 0.000230287213313501 NA NA NA hsa-miR-130b-3p GNB5 -0.221667315324818 0.824660172394714 -0.0649528135314408 0.938218455897553 miRNAWalker2_validate -0.273482376291113 4.037374696104e-06 NA NA NA hsa-miR-148a-3p GNB5 -0.101286586375016 0.976980454193186 -0.0649528135314408 0.938218455897553 miRNAWalker2_validate -0.383298605115451 3.0389598343895e-11 NA NA NA hsa-miR-17-5p GNB5 -0.175448849583061 0.934544015912731 -0.0649528135314408 0.938218455897553 TargetScan -0.356805592068732 2.12915653285483e-13 NA NA NA hsa-miR-26b-5p GNB5 -0.0245931278499594 0.990377966314923 -0.0649528135314408 0.938218455897553 miRNAWalker2_validate -0.299348321837633 0.000113963512166663 NA NA NA hsa-miR-27a-3p GNB5 -0.123902317731458 0.958804393510999 -0.0649528135314408 0.938218455897553 miRNAWalker2_validate -0.374667661574724 5.34111755135333e-05 NA NA NA hsa-miR-361-5p GNB5 -0.138735309928775 0.941495130308343 -0.0649528135314408 0.938218455897553 miRanda -0.426377614029263 1.31175910214088e-05 NA NA NA hsa-miR-425-5p GNB5 -0.354606074344121 0.845979106734409 -0.0649528135314408 0.938218455897553 miRNAWalker2_validate -0.286665566892633 4.13300378904745e-08 NA NA NA hsa-miR-429 GNB5 -0.456485631615963 0.806240953400535 -0.0649528135314408 0.938218455897553 miRanda -0.33677300920156 1.19834345545659e-14 NA NA NA hsa-miR-452-3p GNB5 -0.167134177977311 0.799008246175244 -0.0649528135314408 0.938218455897553 mirMAP -0.225516801818803 2.3903738192163e-08 NA NA NA hsa-miR-590-3p GNB5 -0.279244755376859 0.59126669933662 -0.0649528135314408 0.938218455897553 miRanda -0.140750566851599 0.00391178630566149 NA NA NA hsa-miR-126-5p GNG12 0.0815213541035824 0.956637332055185 -0.142668426794612 0.929391620324368 mirMAP -0.185177316145845 0.000122141017476559 NA NA NA hsa-miR-409-5p GNG12 0.114137352474602 0.862758126973031 -0.142668426794612 0.929391620324368 PITA -0.110560226623452 0.000614581063746225 NA NA NA hsa-miR-455-5p GNG12 -0.139599153671262 0.865744220236311 -0.142668426794612 0.929391620324368 miRanda -0.123706173617567 0.00119377079445104 NA NA NA hsa-miR-23a-3p GNG2 -0.122198715333656 0.962717452143511 0.0195340430449504 0.979278777912881 miRNATAP -0.586749326631971 1.18805552862352e-06 NA NA NA hsa-miR-29a-3p GNG2 0.01127474410284 0.996977020481272 0.0195340430449504 0.979278777912881 miRNATAP -0.521964008408501 5.4920831631013e-10 NA NA NA hsa-miR-29b-3p GNG2 -0.104016192263954 0.958988036765397 0.0195340430449504 0.979278777912881 miRNATAP -0.464301471964614 1.15162439366794e-13 NA NA NA hsa-miR-30d-3p GNG2 -0.123474741320298 0.814905367625791 0.0195340430449504 0.979278777912881 mirMAP -0.432540716773994 1.44634964537532e-09 NA NA NA hsa-miR-324-5p GNG2 -0.50063248413014 0.537416710557032 0.0195340430449504 0.979278777912881 miRanda -0.366129018316216 8.00496961037959e-08 NA NA NA hsa-miR-335-3p GNG2 -0.244830745789445 0.88450019116631 0.0195340430449504 0.979278777912881 mirMAP -0.405349421816321 2.19102607784949e-12 NA NA NA hsa-miR-429 GNG2 -0.456485631615963 0.806240953400535 0.0195340430449504 0.979278777912881 miRanda;miRNATAP -0.373755953883467 4.98629894373416e-14 NA NA NA hsa-miR-500a-5p GNG2 -0.71978560736831 0.188073776225276 0.0195340430449504 0.979278777912881 mirMAP -0.357661536606533 5.12404737407786e-11 NA NA NA hsa-miR-576-5p GNG2 -0.506413219377403 0.417187951364173 0.0195340430449504 0.979278777912881 mirMAP -0.329879268691927 3.99552599442828e-07 NA NA NA hsa-miR-577 GNG2 -1.06238199218774 0.326056761787754 0.0195340430449504 0.979278777912881 PITA;miRNATAP -0.211919490683742 1.74956879440225e-10 NA NA NA hsa-miR-590-3p GNG2 -0.279244755376859 0.59126669933662 0.0195340430449504 0.979278777912881 PITA;miRanda;mirMAP;miRNATAP -0.303311140058288 1.78060575179079e-08 NA NA NA hsa-miR-590-5p GNG2 -0.547819833829572 0.472735645776647 0.0195340430449504 0.979278777912881 miRanda;miRNATAP -0.439716839118106 1.22994799871499e-15 NA NA NA hsa-miR-107 GNG4 -0.0365118169251648 0.988364120226869 1.84581685520606 0.106830658057134 miRanda -1.27199608515578 0.000391434796021852 NA NA NA hsa-miR-326 GNG4 -0.567362118421427 0.620696901956282 1.84581685520606 0.106830658057134 mirMAP -0.591891390234571 0.00769380962383159 NA NA NA hsa-miR-92b-3p GNG4 -0.569866984318692 0.689321861489779 1.84581685520606 0.106830658057134 mirMAP -1.2700609691718 1.42912811264855e-10 NA NA NA hsa-let-7e-5p GNG5 0.211156073215582 0.922335699862928 -0.0596525576668432 0.969200086592649 miRNAWalker2_validate;MirTarget;miRNATAP -0.152599954940069 0.000935964234834591 NA NA NA hsa-miR-100-5p GNG5 0.0230258429671419 0.992818348620337 -0.0596525576668432 0.969200086592649 miRNAWalker2_validate -0.110038434475218 6.92564352999007e-06 NA NA NA hsa-miR-1254 GNG7 -0.488929355953681 0.19551794273322 0.246962625535847 0.547777583589041 miRNATAP -0.238000091347327 0.00103086348244356 NA NA NA hsa-miR-1275 GNG7 -0.831342050607648 0.0803795852164229 0.246962625535847 0.547777583589041 MirTarget -0.253274883294583 8.49390362621298e-06 NA NA NA hsa-miR-141-3p GNG7 -0.31994058840327 0.87774106909065 0.246962625535847 0.547777583589041 MirTarget;TargetScan;miRNATAP -0.426609282329358 1.71346927725291e-08 NA NA NA hsa-miR-17-3p GNG7 0.100221625453134 0.960113387014848 0.246962625535847 0.547777583589041 mirMAP -0.457795100534964 5.89732785575079e-07 NA NA NA hsa-miR-185-3p GNG7 0.100697585937245 0.856913315942984 0.246962625535847 0.547777583589041 mirMAP -0.339810106428788 0.000274824912019918 NA NA NA hsa-miR-18a-3p GNG7 -0.270443061178857 0.535291623032886 0.246962625535847 0.547777583589041 mirMAP -0.372675848820419 8.40351957213415e-09 NA NA NA hsa-miR-18a-5p GNG7 -0.498318455303917 0.61264091975585 0.246962625535847 0.547777583589041 mirMAP -0.364039130076836 2.46209226912081e-08 NA NA NA hsa-miR-18b-5p GNG7 -0.0473300652227538 0.899981261531446 0.246962625535847 0.547777583589041 mirMAP -0.29344950018203 5.72431189988229e-06 NA NA NA hsa-miR-194-3p GNG7 -0.614465699221301 0.733214497063146 0.246962625535847 0.547777583589041 mirMAP -0.410204751461776 2.53365558396796e-08 NA NA NA hsa-miR-200a-3p GNG7 -0.367034437440907 0.851059894150266 0.246962625535847 0.547777583589041 MirTarget;miRNATAP -0.270525770292695 0.000324574104520852 NA NA NA hsa-miR-224-5p GNG7 -0.240425158977724 0.857351098476517 0.246962625535847 0.547777583589041 mirMAP -0.226345207198485 0.000704216351614613 NA NA NA hsa-miR-23a-3p GNG7 -0.122198715333656 0.962717452143511 0.246962625535847 0.547777583589041 mirMAP -0.662403717203233 8.36604672470328e-05 NA NA NA hsa-miR-29b-3p GNG7 -0.104016192263954 0.958988036765397 0.246962625535847 0.547777583589041 mirMAP -0.324547807263863 0.000339788096249608 NA NA NA hsa-miR-378a-3p GNG7 -0.466787210598086 0.795055970353024 0.246962625535847 0.547777583589041 mirMAP -0.276746787489566 0.00640129635092456 NA NA NA hsa-miR-500a-3p GNG7 -0.633375813338735 0.732582832733155 0.246962625535847 0.547777583589041 mirMAP -0.454023927839378 4.92459324117066e-07 NA NA NA hsa-miR-532-3p GNG7 -0.496590111092324 0.682889021782543 0.246962625535847 0.547777583589041 mirMAP -0.354741011856059 1.32513389076964e-05 NA NA NA hsa-miR-590-3p GNG7 -0.279244755376859 0.59126669933662 0.246962625535847 0.547777583589041 PITA;miRanda;mirMAP -0.321886723997531 2.03158812402469e-05 NA NA NA hsa-miR-671-5p GNG7 -0.373754118103105 0.411207779636977 0.246962625535847 0.547777583589041 mirMAP -0.520896997203422 1.71810553995385e-08 NA NA NA hsa-miR-92a-3p GNG7 0.0278830870766349 0.993247426671713 0.246962625535847 0.547777583589041 miRNAWalker2_validate -0.521267148270826 1.29668623808043e-08 NA NA NA hsa-miR-939-5p GNG7 -0.311196961912953 0.304447903545905 0.246962625535847 0.547777583589041 mirMAP -0.360632599824294 5.47831469766152e-06 NA NA NA hsa-miR-940 GNG7 -0.225788347550697 0.680055767105815 0.246962625535847 0.547777583589041 MirTarget -0.325319226450819 4.03321988919025e-07 NA NA NA hsa-miR-96-5p GNG7 0.0854810872029343 0.923087820185031 0.246962625535847 0.547777583589041 mirMAP -0.217584414157617 0.00558972226725726 NA NA NA hsa-miR-30c-1-3p GNGT2 -0.202466672579761 0.511485842123022 -0.283259474818092 0.395401322995797 MirTarget -0.315791055608415 9.18901662482701e-07 NA NA NA hsa-miR-335-5p GNGT2 -0.0284895175847679 0.973380867832231 -0.283259474818092 0.395401322995797 miRNAWalker2_validate -0.507290035048998 1.40241268864283e-14 NA NA NA hsa-miR-132-3p GSK3B -0.244143673573889 0.871752726220643 -0.0279273799391531 0.984168396316634 mirMAP;miRNATAP -0.110221716663843 0.000912142142693881 NA NA NA hsa-miR-146b-3p GSK3B -0.408862981477661 0.762520540478861 -0.0279273799391531 0.984168396316634 miRNATAP -0.124674628963768 4.92920707796624e-08 NA NA NA hsa-miR-146b-5p GSK3B -0.402662509440887 0.837510937985091 -0.0279273799391531 0.984168396316634 miRanda -0.144433253868449 1.55437010316677e-09 NA NA NA hsa-miR-155-5p GSK3B -0.407235807706004 0.828669616718496 -0.0279273799391531 0.984168396316634 miRNAWalker2_validate;miRNATAP -0.101330604682835 1.443796438774e-06 NA NA NA hsa-miR-212-3p GSK3B -0.0224067199236484 0.973232008101458 -0.0279273799391531 0.984168396316634 mirMAP;miRNATAP -0.114396409575091 1.59972400030542e-05 NA NA NA hsa-let-7a-3p HGF -0.215598045625677 0.85543299203799 -0.215102594830841 0.643434051530302 mirMAP -0.88420347185405 1.1709285303706e-11 NA NA NA hsa-let-7f-1-3p HGF -0.31101436822914 0.693407210545374 -0.215102594830841 0.643434051530302 mirMAP -0.831761669295677 5.5433774063152e-06 NA NA NA hsa-miR-126-5p HGF 0.0815213541035824 0.956637332055185 -0.215102594830841 0.643434051530302 mirMAP -0.519453817781097 0.000972844074417936 NA NA NA hsa-miR-140-5p HGF -0.229213026275906 0.847330111738616 -0.215102594830841 0.643434051530302 miRanda -0.65487174403206 0.000253507908779553 NA NA NA hsa-miR-141-3p HGF -0.31994058840327 0.87774106909065 -0.215102594830841 0.643434051530302 MirTarget;TargetScan -0.730579886607172 1.58446647058152e-13 NA NA NA hsa-miR-200a-3p HGF -0.367034437440907 0.851059894150266 -0.215102594830841 0.643434051530302 MirTarget -0.596497453806514 1.29203788778455e-09 NA NA NA hsa-miR-203a-3p HGF -0.265248086637561 0.931593594361942 -0.215102594830841 0.643434051530302 MirTarget -0.461332142848555 2.60147483748182e-07 NA NA NA hsa-miR-26b-5p HGF -0.0245931278499594 0.990377966314923 -0.215102594830841 0.643434051530302 MirTarget;miRNATAP -1.17315397215506 4.58480300345712e-14 NA NA NA hsa-miR-29a-5p HGF -0.31835175571979 0.600442757817281 -0.215102594830841 0.643434051530302 mirMAP -0.708270081145091 5.09040194854006e-11 NA NA NA hsa-miR-30b-5p HGF -0.0121430518253582 0.994622896704513 -0.215102594830841 0.643434051530302 mirMAP -0.730375715452008 3.65541666930056e-10 NA NA NA hsa-miR-30c-5p HGF -0.298383882401475 0.865809030482001 -0.215102594830841 0.643434051530302 mirMAP -0.897019003354754 1.14472391149967e-07 NA NA NA hsa-miR-30e-5p HGF -0.0657075181381011 0.979684509181941 -0.215102594830841 0.643434051530302 mirMAP -0.58046350738056 0.00239259261354955 NA NA NA hsa-miR-335-3p HGF -0.244830745789445 0.88450019116631 -0.215102594830841 0.643434051530302 mirMAP -0.39255303662723 0.000430581302657786 NA NA NA hsa-miR-338-3p HGF 0.49158501750012 0.788483749194189 -0.215102594830841 0.643434051530302 miRanda -0.295029479608896 0.00119469331586222 NA NA NA hsa-miR-33a-3p HGF -0.794543849238581 0.0105203072007922 -0.215102594830841 0.643434051530302 mirMAP -0.485665076665164 2.0568759682243e-06 NA NA NA hsa-miR-421 HGF -0.182032017078616 0.734704500318599 -0.215102594830841 0.643434051530302 miRanda -0.35008082810766 0.00288860800589552 NA NA NA hsa-miR-429 HGF -0.456485631615963 0.806240953400535 -0.215102594830841 0.643434051530302 miRanda -0.631479963725932 1.15314842800372e-11 NA NA NA hsa-miR-582-5p HGF -0.399450205475138 0.581227478860085 -0.215102594830841 0.643434051530302 PITA -0.652283879342961 5.81074982694297e-07 NA NA NA hsa-miR-590-3p HGF -0.279244755376859 0.59126669933662 -0.215102594830841 0.643434051530302 miRanda;mirMAP -0.738231418622318 2.66582687148553e-14 NA NA NA hsa-miR-590-5p HGF -0.547819833829572 0.472735645776647 -0.215102594830841 0.643434051530302 miRanda -0.824314223851123 5.14472586927879e-16 NA NA NA hsa-miR-651-5p HGF -0.571699708815578 0.172535889612301 -0.215102594830841 0.643434051530302 MirTarget -0.452996451589744 5.92177771892613e-07 NA NA NA hsa-miR-7-1-3p HGF -0.462485777435991 0.665899751398166 -0.215102594830841 0.643434051530302 mirMAP -0.71251071506092 8.68300493786797e-10 NA NA NA hsa-miR-217 HSP90AA1 0.341080669095094 0.760998144794468 -0.134733743661558 0.954930645942692 miRanda -0.106780477092404 9.98858455741931e-05 NA NA NA hsa-miR-30c-5p HSP90AA1 -0.298383882401475 0.865809030482001 -0.134733743661558 0.954930645942692 miRNAWalker2_validate -0.150210412138148 0.00392579356598822 NA NA NA hsa-miR-30e-5p HSP90AA1 -0.0657075181381011 0.979684509181941 -0.134733743661558 0.954930645942692 miRNAWalker2_validate -0.155699918646794 0.00694124179085005 NA NA NA hsa-miR-361-5p HSP90AA1 -0.138735309928775 0.941495130308343 -0.134733743661558 0.954930645942692 MirTarget;PITA;miRanda -0.17699837374364 0.00472607299700645 NA NA NA hsa-miR-411-5p HSP90AA1 0.214386048204938 0.765265936515842 -0.134733743661558 0.954930645942692 MirTarget -0.107272058872786 0.00968599692468851 NA NA NA hsa-let-7b-3p HSP90AB1 -0.286212135502696 0.812160509578046 -0.017225379906634 0.994426352461203 miRNATAP -0.130784476189137 0.000664813698782632 NA NA NA hsa-miR-181c-5p HSP90B1 0.042951891660695 0.969159991881861 -0.381438425264037 0.869916204186928 MirTarget -0.100425081173463 0.00474436440007676 NA NA NA hsa-miR-181d-5p HSP90B1 0.14926527647499 0.888000971478017 -0.381438425264037 0.869916204186928 MirTarget -0.100159609810288 0.000301370854034308 NA NA NA hsa-miR-106b-5p IFNAR2 -0.297128724729339 0.869294443540749 0.0549290953725192 0.956270498622373 miRNAWalker2_validate -0.119924026344003 0.000258511606081136 NA NA NA hsa-let-7a-3p IGF1 -0.215598045625677 0.85543299203799 0.00947737435165086 0.987467926907962 mirMAP -1.080447980324 1.8079365656541e-11 NA NA NA hsa-let-7f-1-3p IGF1 -0.31101436822914 0.693407210545374 0.00947737435165086 0.987467926907962 mirMAP -1.33703011462655 1.62041677524579e-09 NA NA NA hsa-miR-1275 IGF1 -0.831342050607648 0.0803795852164229 0.00947737435165086 0.987467926907962 MirTarget;PITA -0.38101781548121 5.45983739511041e-05 NA NA NA hsa-miR-130b-3p IGF1 -0.221667315324818 0.824660172394714 0.00947737435165086 0.987467926907962 MirTarget -1.32997411476354 1.36901225432237e-20 NA NA NA hsa-miR-148a-5p IGF1 -0.448099743845604 0.748419139652266 0.00947737435165086 0.987467926907962 mirMAP -0.731184313112099 6.87872094016325e-07 NA NA NA hsa-miR-15b-3p IGF1 -0.557749208157585 0.609181305423188 0.00947737435165086 0.987467926907962 mirMAP -1.37193595831155 3.68702917896959e-22 NA NA NA hsa-miR-16-1-3p IGF1 0.151694812889216 0.733736501874638 0.00947737435165086 0.987467926907962 mirMAP -0.870110401826923 9.48782291894495e-12 NA NA NA hsa-miR-186-5p IGF1 -0.318786974828757 0.85412722938961 0.00947737435165086 0.987467926907962 mirMAP -1.35027272960641 3.80273001614756e-11 NA NA NA hsa-miR-19a-3p IGF1 -0.206793507801887 0.844637784802316 0.00947737435165086 0.987467926907962 MirTarget -0.98551271469101 4.98535421174768e-17 NA NA NA hsa-miR-19b-1-5p IGF1 -0.0105982583216702 0.988511655226679 0.00947737435165086 0.987467926907962 mirMAP -0.955450359137311 6.7696545868365e-13 NA NA NA hsa-miR-19b-3p IGF1 -0.0268530183621474 0.986656783046572 0.00947737435165086 0.987467926907962 MirTarget -1.18511578469291 3.16855554305294e-17 NA NA NA hsa-miR-20a-3p IGF1 0.456808229166028 0.57674056136504 0.00947737435165086 0.987467926907962 mirMAP -0.828202370369737 4.46601232058444e-17 NA NA NA hsa-miR-224-3p IGF1 0.110372723153393 0.749091467231007 0.00947737435165086 0.987467926907962 mirMAP -0.323141310332858 0.00752558553987227 NA NA NA hsa-miR-26b-5p IGF1 -0.0245931278499594 0.990377966314923 0.00947737435165086 0.987467926907962 mirMAP -1.32653848815452 7.59461749262891e-12 NA NA NA hsa-miR-27a-3p IGF1 -0.123902317731458 0.958804393510999 0.00947737435165086 0.987467926907962 miRNAWalker2_validate;miRTarBase -1.33297141089179 1.59629899773494e-08 NA NA NA hsa-miR-29a-3p IGF1 0.01127474410284 0.996977020481272 0.00947737435165086 0.987467926907962 MirTarget -1.21646810613425 2.24809293601906e-10 NA NA NA hsa-miR-29b-3p IGF1 -0.104016192263954 0.958988036765397 0.00947737435165086 0.987467926907962 MirTarget -1.13478255405874 1.02581838525823e-15 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 -0.105312511901769 0.831686745977347 0.00947737435165086 0.987467926907962 MirTarget -0.72462477830808 1.53712615625093e-08 NA NA NA hsa-miR-32-3p IGF1 -0.568003960723004 0.13133163420273 0.00947737435165086 0.987467926907962 mirMAP -0.854296588628844 6.36098490896109e-17 NA NA NA hsa-miR-320a IGF1 -0.416546433767628 0.840202138616422 0.00947737435165086 0.987467926907962 miRNATAP -0.53324783195833 0.00309104675893166 NA NA NA hsa-miR-33a-3p IGF1 -0.794543849238581 0.0105203072007922 0.00947737435165086 0.987467926907962 MirTarget -0.712659254532177 1.07475387901444e-08 NA NA NA hsa-miR-361-5p IGF1 -0.138735309928775 0.941495130308343 0.00947737435165086 0.987467926907962 PITA;mirMAP -0.7571457599163 0.00312625171582628 NA NA NA hsa-miR-362-5p IGF1 -0.26647467080141 0.752024885130738 0.00947737435165086 0.987467926907962 mirMAP -0.685362314110393 1.45434246224861e-09 NA NA NA hsa-miR-369-3p IGF1 0.116576891957687 0.83230082995912 0.00947737435165086 0.987467926907962 mirMAP -0.416113550798216 0.00731803332568262 NA NA NA hsa-miR-374b-3p IGF1 -0.0542885924440247 0.860753623992354 0.00947737435165086 0.987467926907962 mirMAP -0.901177033447461 2.85340453160353e-08 NA NA NA hsa-miR-376b-3p IGF1 -0.00712550627858333 0.982426403308526 0.00947737435165086 0.987467926907962 mirMAP -0.400180241759986 0.00219046891964139 NA NA NA hsa-miR-377-3p IGF1 -0.0435868040110954 0.893514136702459 0.00947737435165086 0.987467926907962 mirMAP -0.347398016761275 0.00944572443583628 NA NA NA hsa-miR-421 IGF1 -0.182032017078616 0.734704500318599 0.00947737435165086 0.987467926907962 PITA -0.682640976463619 1.66568557959283e-06 NA NA NA hsa-miR-450b-5p IGF1 -0.0136687538973108 0.983149761399849 0.00947737435165086 0.987467926907962 MirTarget;PITA;mirMAP;miRNATAP -0.440274691286941 0.00526886632157137 NA NA NA hsa-miR-452-5p IGF1 -0.0504626418153507 0.973874641360401 0.00947737435165086 0.987467926907962 MirTarget;mirMAP -0.391677573462921 0.00721587803462884 NA NA NA hsa-miR-454-3p IGF1 -0.101514866328011 0.843545158256191 0.00947737435165086 0.987467926907962 MirTarget -1.21083489236632 2.3904507521785e-12 NA NA NA hsa-miR-486-5p IGF1 -0.547739229538641 0.696404149927963 0.00947737435165086 0.987467926907962 PITA;miRNATAP -0.27962476093108 0.00602263294023068 NA NA NA hsa-miR-576-5p IGF1 -0.506413219377403 0.417187951364173 0.00947737435165086 0.987467926907962 PITA;mirMAP;miRNATAP -1.07532866336442 7.30778925637395e-14 NA NA NA hsa-miR-577 IGF1 -1.06238199218774 0.326056761787754 0.00947737435165086 0.987467926907962 PITA -0.608739982603203 1.28953846721018e-16 NA NA NA hsa-miR-590-3p IGF1 -0.279244755376859 0.59126669933662 0.00947737435165086 0.987467926907962 MirTarget;miRanda;mirMAP;miRNATAP -0.902455239090903 4.54122052117076e-14 NA NA NA hsa-miR-592 IGF1 -0.177670083168544 0.856226890424691 0.00947737435165086 0.987467926907962 mirMAP -0.176568829642714 0.00558894888386371 NA NA NA hsa-miR-629-5p IGF1 -0.385679366494342 0.798536530066869 0.00947737435165086 0.987467926907962 mirMAP -0.580583415149519 2.61578695347913e-05 NA NA NA hsa-miR-940 IGF1 -0.225788347550697 0.680055767105815 0.00947737435165086 0.987467926907962 MirTarget;PITA;miRNATAP -0.565084064749585 9.24954782359072e-08 NA NA NA hsa-let-7a-5p IGF1R -0.0620211756550422 0.985006886285188 -0.103803406345425 0.938733891850032 MirTarget;TargetScan;miRNATAP -0.243160250350556 0.00491064759282066 23974362 Reduced microRNA miRNA let-7a expression and the activation of insulin-like growth factor-1 receptor IGF1R signalling are both involved in prostate cancer and progression; TargetScan predicted three potential target sites T1 T2 and T3 of let-7a in the 3' untranslational region 3' UTR of IGF1R mRNA progression prostate cancer hsa-let-7f-5p IGF1R 0.048789917034723 0.987280455481631 -0.103803406345425 0.938733891850032 MirTarget;miRNATAP -0.256299916151521 0.000451131242842245 NA NA NA hsa-miR-141-5p IGF1R -0.354590233549885 0.867642456336402 -0.103803406345425 0.938733891850032 mirMAP -0.113052742477114 0.00877702512535289 27648145 Insulin-like growth factor 1 receptor IGF1R was overexpressed in AGS cells to investigate miR-141 mechanism gastric cancer hsa-miR-146b-5p IGF1R -0.402662509440887 0.837510937985091 -0.103803406345425 0.938733891850032 miRanda -0.173301214951841 0.00128805370965098 NA NA NA hsa-miR-148a-5p IGF1R -0.448099743845604 0.748419139652266 -0.103803406345425 0.938733891850032 mirMAP -0.148035854798968 0.00161166437750514 NA NA NA hsa-miR-155-5p IGF1R -0.407235807706004 0.828669616718496 -0.103803406345425 0.938733891850032 mirMAP -0.157172052561045 0.000741470115136315 NA NA NA hsa-miR-15a-5p IGF1R -0.0674049094129128 0.964835434214123 -0.103803406345425 0.938733891850032 miRNATAP -0.216892021259061 0.000131806631798513 NA NA NA hsa-miR-15b-5p IGF1R -0.272614787130877 0.87096541832188 -0.103803406345425 0.938733891850032 miRNATAP -0.162032707167887 0.00249732533293442 NA NA NA hsa-miR-16-5p IGF1R 0.0135949734723564 0.994476223855607 -0.103803406345425 0.938733891850032 miRNATAP -0.147034771165486 0.00601666576845021 23507142 Furthermore we confirmed that IGF1R is a direct target of miR-16; In clinical specimens IGF1R levels inversely correlate with miR-16 expression; Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS sarcoma hsa-miR-185-5p IGF1R -0.294432218239008 0.820591478398594 -0.103803406345425 0.938733891850032 MirTarget -0.291974153890838 9.35911241773559e-06 NA NA NA hsa-miR-186-5p IGF1R -0.318786974828757 0.85412722938961 -0.103803406345425 0.938733891850032 mirMAP -0.189895543661092 0.00437029938165362 NA NA NA hsa-miR-378a-3p IGF1R -0.466787210598086 0.795055970353024 -0.103803406345425 0.938733891850032 miRTarBase;MirTarget;miRNATAP -0.164856274068005 0.00167500175777631 24119742;25427715;24412052 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS; MiR-378a-3p over-expression in an RMS-derived cell line suppressed IGF1R expression and affected phosphorylated-Akt protein levels;Furthermore miR-378a-3p over-expression or down-regulation could inhibit or enhance insulin-like growth factor 1 receptor IGF1R expression in CRC cells; There was a significantly negative correlation between IGF1R protein expression and miR-378a-3p expression in CRC tissues ;; liver cancer;sarcoma;colorectal cancer hsa-miR-378a-5p IGF1R -0.559739196974497 0.724882066659501 -0.103803406345425 0.938733891850032 mirMAP -0.175396977324042 0.00026465398131805 24119742;25427715 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS ; liver cancer;sarcoma hsa-miR-484 IGF1R -0.179977202691249 0.886333755572375 -0.103803406345425 0.938733891850032 miRNAWalker2_validate -0.245668841067247 2.83524395118817e-05 NA NA NA hsa-miR-625-5p IGF1R -0.690759472145277 0.210306534567564 -0.103803406345425 0.938733891850032 MirTarget -0.103547661533949 0.0029191222627627 NA NA NA hsa-miR-629-3p IGF1R -0.495402745812008 0.333967382214384 -0.103803406345425 0.938733891850032 mirMAP -0.122852401902141 0.00121467574004489 NA NA NA hsa-miR-671-5p IGF1R -0.373754118103105 0.411207779636977 -0.103803406345425 0.938733891850032 mirMAP -0.127729526914725 0.0095060454236158 NA NA NA hsa-miR-7-5p IGF1R 0.209645143210379 0.773705612298441 -0.103803406345425 0.938733891850032 miRNAWalker2_validate;mirMAP -0.123016255458274 2.76809127732144e-05 22614005 Moreover the insulin-like growth factor-1 receptor IGF1R oncogene which is often mutated or amplified in human cancers and functions as an important regulator of cell growth and tumor invasion was identified as a direct target of miR-7; Silencing of IGF1R using small interefering RNA siRNA recapitulated the anti-metastatic function of miR-7 whereas restoring the IGF1R expression attenuated the function of miR-7 in GC cells; Finally analyses of miR-7 and IGF1R levels in human primary GC with matched lymph node metastasis tissue arrays revealed that miR-7 is inversely correlated with IGF1R expression metastasis gastric cancer hsa-let-7a-5p IGF2 -0.0620211756550422 0.985006886285188 0.558178390369186 0.699874555090261 miRNAWalker2_validate;miRTarBase -1.32775282562246 0.000276437161830582 NA NA NA hsa-miR-141-3p IGF2 -0.31994058840327 0.87774106909065 0.558178390369186 0.699874555090261 MirTarget;TargetScan -0.690444519894233 4.62610267953503e-05 NA NA NA hsa-miR-148a-3p IGF2 -0.101286586375016 0.976980454193186 0.558178390369186 0.699874555090261 mirMAP -0.605151946492803 0.00346322379059377 NA NA NA hsa-miR-192-5p IGF2 -0.117345487848223 0.972927287653137 0.558178390369186 0.699874555090261 mirMAP -0.665311544607333 2.50041119586102e-05 NA NA NA hsa-miR-200a-3p IGF2 -0.367034437440907 0.851059894150266 0.558178390369186 0.699874555090261 MirTarget -0.546401873597961 0.00100494917147672 NA NA NA hsa-miR-210-3p IGF2 -0.531610638853144 0.78220772117333 0.558178390369186 0.699874555090261 MirTarget -0.419493273578115 0.000199381136218303 NA NA NA hsa-miR-663b IGF2 0.101100389887233 0.814989939749933 0.558178390369186 0.699874555090261 mirMAP -0.375405545344549 0.00418142774332847 NA NA NA hsa-miR-224-3p IL2RA 0.110372723153393 0.749091467231007 -0.417788171272967 0.415377591508965 MirTarget -0.358356636913746 0.000226508715698861 NA NA NA hsa-miR-500a-3p IL2RA -0.633375813338735 0.732582832733155 -0.417788171272967 0.415377591508965 MirTarget -0.352734550527931 0.00419836632010245 NA NA NA hsa-miR-421 IL2RB -0.182032017078616 0.734704500318599 -0.861924307640201 0.313939459147822 mirMAP -0.291499452428397 0.00219078812803157 NA NA NA hsa-miR-362-3p IL3RA -0.721040238345347 0.0345881362485733 0.163928312094029 0.804758258942851 miRanda -0.169156809721412 0.00190481779053269 NA NA NA hsa-miR-335-5p IL6 -0.0284895175847679 0.973380867832231 0.0493336463322382 0.935900126013578 miRNAWalker2_validate -0.521128064809697 0.000256062993843235 NA NA NA hsa-miR-429 IL6 -0.456485631615963 0.806240953400535 0.0493336463322382 0.935900126013578 miRanda -0.46097989287392 0.000176679583532699 NA NA NA hsa-let-7g-5p IL6R -0.200947212961157 0.922992045181955 0.14029594340371 0.828138988034461 miRNATAP -0.504676085284238 0.000139207492000278 NA NA NA hsa-miR-106b-5p IL6R -0.297128724729339 0.869294443540749 0.14029594340371 0.828138988034461 mirMAP -0.414993313904555 1.66588405858962e-05 NA NA NA hsa-miR-130b-3p IL6R -0.221667315324818 0.824660172394714 0.14029594340371 0.828138988034461 mirMAP -0.37520088997967 1.41242079938231e-05 NA NA NA hsa-miR-141-3p IL6R -0.31994058840327 0.87774106909065 0.14029594340371 0.828138988034461 MirTarget -0.260278088312821 0.000281825033488117 NA NA NA hsa-miR-141-5p IL6R -0.354590233549885 0.867642456336402 0.14029594340371 0.828138988034461 MirTarget -0.223418998455398 0.00375220429656306 NA NA NA hsa-miR-148a-5p IL6R -0.448099743845604 0.748419139652266 0.14029594340371 0.828138988034461 mirMAP -0.222029065891081 0.00845183949353713 NA NA NA hsa-miR-17-5p IL6R -0.175448849583061 0.934544015912731 0.14029594340371 0.828138988034461 mirMAP -0.348432376185475 1.8700645271031e-06 NA NA NA hsa-miR-182-5p IL6R -0.104238497940557 0.973380614062243 0.14029594340371 0.828138988034461 mirMAP -0.283194457844622 0.000138166201195752 NA NA NA hsa-miR-193b-3p IL6R 0.0672068426635715 0.951480422273678 0.14029594340371 0.828138988034461 mirMAP -0.238067342254597 0.00256577376604153 NA NA NA hsa-miR-200a-3p IL6R -0.367034437440907 0.851059894150266 0.14029594340371 0.828138988034461 MirTarget -0.203072468846452 0.00380625152233845 NA NA NA hsa-miR-20a-5p IL6R -0.179153323927949 0.928118119139752 0.14029594340371 0.828138988034461 mirMAP -0.312547682443889 1.55742175867736e-05 NA NA NA hsa-miR-29a-5p IL6R -0.31835175571979 0.600442757817281 0.14029594340371 0.828138988034461 mirMAP -0.259936171679278 0.000767742491585924 NA NA NA hsa-miR-29b-1-5p IL6R -0.642348119412534 0.293891497238796 0.14029594340371 0.828138988034461 mirMAP -0.167846750014706 0.00553245052066504 NA NA NA hsa-miR-30b-5p IL6R -0.0121430518253582 0.994622896704513 0.14029594340371 0.828138988034461 mirMAP -0.261870960822981 0.00166231883367778 NA NA NA hsa-miR-30c-5p IL6R -0.298383882401475 0.865809030482001 0.14029594340371 0.828138988034461 mirMAP -0.349580599174505 0.00346490473427868 NA NA NA hsa-miR-331-3p IL6R -0.40204226129616 0.670588911553669 0.14029594340371 0.828138988034461 MirTarget -0.242281109107159 0.00805273236084106 NA NA NA hsa-miR-335-5p IL6R -0.0284895175847679 0.973380867832231 0.14029594340371 0.828138988034461 mirMAP -0.315149839964086 4.29309729140907e-05 NA NA NA hsa-miR-33a-5p IL6R -0.205788753603336 0.853314500865147 0.14029594340371 0.828138988034461 mirMAP -0.173517877899447 0.000139955248140828 NA NA NA hsa-miR-454-3p IL6R -0.101514866328011 0.843545158256191 0.14029594340371 0.828138988034461 mirMAP -0.322679864043225 0.00143735279785052 NA NA NA hsa-miR-484 IL6R -0.179977202691249 0.886333755572375 0.14029594340371 0.828138988034461 MirTarget -0.288401799761055 0.00664672938128289 NA NA NA hsa-miR-576-5p IL6R -0.506413219377403 0.417187951364173 0.14029594340371 0.828138988034461 mirMAP -0.258425586928707 0.00235230304287871 NA NA NA hsa-miR-590-5p IL6R -0.547819833829572 0.472735645776647 0.14029594340371 0.828138988034461 MirTarget;miRNATAP -0.224061981438517 0.00276804787475256 NA NA NA hsa-miR-93-5p IL6R -0.611073677204699 0.825297877093193 0.14029594340371 0.828138988034461 mirMAP -0.347827855898408 0.000144066850938172 NA NA NA hsa-miR-126-5p IL7R 0.0815213541035824 0.956637332055185 -0.627859794552579 0.295298335743483 mirMAP -0.4756907745373 0.00657032601364036 NA NA NA hsa-miR-26b-5p IL7R -0.0245931278499594 0.990377966314923 -0.627859794552579 0.295298335743483 miRNAWalker2_validate -0.870942517484309 1.07879495037811e-06 NA NA NA hsa-miR-335-3p IL7R -0.244830745789445 0.88450019116631 -0.627859794552579 0.295298335743483 mirMAP -0.442565943876017 0.000333568517152847 NA NA NA hsa-miR-501-5p IL7R -0.834032628506285 0.0582725160418523 -0.627859794552579 0.295298335743483 mirMAP -0.311813185428204 0.00199338402988381 NA NA NA hsa-miR-576-5p IL7R -0.506413219377403 0.417187951364173 -0.627859794552579 0.295298335743483 mirMAP -0.400800086526563 0.00323100563379795 NA NA NA hsa-miR-590-3p IL7R -0.279244755376859 0.59126669933662 -0.627859794552579 0.295298335743483 miRanda;mirMAP -0.456236486250003 4.92453207211017e-05 NA NA NA hsa-miR-7-1-3p IL7R -0.462485777435991 0.665899751398166 -0.627859794552579 0.295298335743483 mirMAP -0.4009588706607 0.00253474287499519 NA NA NA hsa-miR-151a-3p INSR -0.0829874640636401 0.975334671097605 -0.257802126655543 0.855679559467316 miRNATAP -0.188107675065737 0.00147636742580037 NA NA NA hsa-miR-335-3p INSR -0.244830745789445 0.88450019116631 -0.257802126655543 0.855679559467316 mirMAP -0.137501879355718 0.000193797807972045 23966614 miR 335 inhibits small cell lung cancer bone metastases via IGF IR and RANKL pathways metastasis lung squamous cell cancer hsa-let-7f-2-3p IRS1 -0.0455032713433074 0.882115725419367 -0.138887664414536 0.910081690996007 MirTarget -0.190264688883992 0.000763306300131466 NA NA NA hsa-miR-126-3p IRS1 -0.106293136341574 0.963670566555251 -0.138887664414536 0.910081690996007 miRNAWalker2_validate;miRTarBase;miRNATAP -0.231205014467248 0.00522556463353807 23981989;24312276;26893720 It has been shown that IRS1 SLC75A and TOM1 were the potential target genes of miR-126 in colon cancer;Down regulation of miR 126 is associated with colorectal cancer cells proliferation migration and invasion by targeting IRS 1 via the AKT and ERK1/2 signaling pathways; In this study we identified the potential effects of miR-126 on some important biological properties of CRC cells and clarified the regulation of insulin receptor substrate 1 IRS-1 and its possible signaling pathway by miR-126; The 3'-untranslated region 3'-UTR of IRS-1 regulated by miR-126 was analyzed by using a dual-luciferase reporter assay; We found that IRS-1 is the functional downstream target of miR-126 by directly targeting the 3'-UTR of IRS-1; Endogenous miR-126 and exogenous miR-126 mimic inhibited IRS-1 expression; Furthermore gain-of-function or loss-of-function studies showed that over-expression of miR-126 down-regulated IRS-1 suppressed AKT and ERK1/2 activation CRC cells proliferation migration invasion and caused cell cycle arrest but had no effect on cell apoptosis; Knockdown of miR-126 promoted these processes in HCT-116 cells and promoted AKT and ERK1/2 activation by up-regulating the expression of the IRS-1 protein; MiR-126 may play roles in regulation of the biological behavior of CRC cells at least in part by targeting IRS-1 via AKT and ERK1/2 signaling pathways;Molecular mechanism investigation established that insulin receptor substrate 1 IRS1 functioned as a direct miR-126 target and its expression was negatively regulated by miR-126 at a post-transcriptional level in the SKOV3 cells; Additionally the overexpression of IRS1 reversed the inhibitory effect of miR-126 overexpression on SKOV3 cell migration and invasion; In conclusion the current study demonstrated that miR-126 inhibited EC cell migration and invasion at least partially through the direct targeting of IRS1 suggesting that miR-126 may aid the treatment of EC metastasis ;;cell migration;metastasis colon cancer;colorectal cancer;endometrial cancer hsa-miR-128-3p IRS1 -0.442192625156042 0.783886533572187 -0.138887664414536 0.910081690996007 MirTarget -0.309782467364502 0.000240062013833522 26352220 In addition insulin receptor substrate 1 IRS1 a key mediator in oncogenic insulin-like growth factor IGF signaling was confirmed as a direct target of miR-128 by a luciferase reporter assay; Western blot analysis indicated that the overexpression of miR-128 significantly downregulated IRS1 expression and its downstream Akt signaling in CRC cells; Moreover miR-128 was negatively associated with IRS1 in CRC tissues compared to adjacent non-tumor tissues; Taken together these data suggested that miR-128 serves as a tumor suppressor and blocks CRC growth and metastasis by targeting IRS1 metastasis colorectal cancer hsa-miR-148a-3p IRS1 -0.101286586375016 0.976980454193186 -0.138887664414536 0.910081690996007 miRNAWalker2_validate;miRTarBase -0.393033423076638 2.04034599475325e-09 NA NA NA hsa-miR-16-1-3p IRS1 0.151694812889216 0.733736501874638 -0.138887664414536 0.910081690996007 MirTarget -0.17384783409095 0.00269395082037564 NA NA NA hsa-miR-17-3p IRS1 0.100221625453134 0.960113387014848 -0.138887664414536 0.910081690996007 MirTarget -0.273025377895073 4.07378912904837e-05 NA NA NA hsa-miR-183-5p IRS1 -0.0549974865878067 0.984855271688809 -0.138887664414536 0.910081690996007 MirTarget;miRNATAP -0.268378896331128 8.54240568080173e-07 NA NA NA hsa-miR-188-3p IRS1 -0.292769686102066 0.475019668859617 -0.138887664414536 0.910081690996007 PITA -0.118935201247173 0.00874145141176737 NA NA NA hsa-miR-200b-3p IRS1 -0.426401948379212 0.863957108574195 -0.138887664414536 0.910081690996007 TargetScan -0.309307734003318 9.57431284984917e-07 26314828 Taken together our results suggest that miR-200 may activate AKT in lung adenocarcinoma cells through a FOG2-independent mechanism involving IRS-1 lung cancer hsa-miR-200c-3p IRS1 -0.437282635857873 0.887118598436407 -0.138887664414536 0.910081690996007 miRNATAP -0.341052252673123 1.34404505054212e-07 NA NA NA hsa-miR-203a-3p IRS1 -0.265248086637561 0.931593594361942 -0.138887664414536 0.910081690996007 MirTarget -0.153832127344777 0.00166855265156521 NA NA NA hsa-miR-30b-5p IRS1 -0.0121430518253582 0.994622896704513 -0.138887664414536 0.910081690996007 MirTarget -0.203251821397175 0.00164438968329683 NA NA NA hsa-miR-30c-5p IRS1 -0.298383882401475 0.865809030482001 -0.138887664414536 0.910081690996007 MirTarget;miRNATAP -0.332495216445426 0.000313577820346467 NA NA NA hsa-miR-30d-5p IRS1 -0.168211838771867 0.95173197030375 -0.138887664414536 0.910081690996007 MirTarget;miRNATAP -0.267224606402832 0.00133536785012315 NA NA NA hsa-miR-335-3p IRS1 -0.244830745789445 0.88450019116631 -0.138887664414536 0.910081690996007 MirTarget -0.315485585988344 7.5909914201907e-08 NA NA NA hsa-miR-33a-5p IRS1 -0.205788753603336 0.853314500865147 -0.138887664414536 0.910081690996007 MirTarget -0.122223765008731 0.000561965362206957 NA NA NA hsa-miR-33b-5p IRS1 -0.161971614375297 0.737436207821109 -0.138887664414536 0.910081690996007 MirTarget -0.104911453609938 0.00788382258274473 NA NA NA hsa-miR-361-5p IRS1 -0.138735309928775 0.941495130308343 -0.138887664414536 0.910081690996007 miRanda -0.52030768468349 2.13243690127728e-06 NA NA NA hsa-miR-421 IRS1 -0.182032017078616 0.734704500318599 -0.138887664414536 0.910081690996007 PITA;miRanda;miRNATAP -0.245873976614244 8.41584945514154e-05 NA NA NA hsa-miR-429 IRS1 -0.456485631615963 0.806240953400535 -0.138887664414536 0.910081690996007 miRanda;miRNATAP -0.256957911878086 4.82876391764834e-07 NA NA NA hsa-miR-491-3p IRS1 -0.513850326596847 0.137836285146052 -0.138887664414536 0.910081690996007 PITA;miRNATAP -0.180310596846654 0.00104432377345941 NA NA NA hsa-miR-590-3p IRS1 -0.279244755376859 0.59126669933662 -0.138887664414536 0.910081690996007 PITA;miRanda;miRNATAP -0.191488844088695 0.000464000312216888 NA NA NA hsa-miR-660-5p IRS1 -0.476129334484339 0.694082832658925 -0.138887664414536 0.910081690996007 MirTarget;miRNATAP -0.350568100658578 1.18516123028506e-07 NA NA NA hsa-miR-7-5p IRS1 0.209645143210379 0.773705612298441 -0.138887664414536 0.910081690996007 miRNAWalker2_validate;miRTarBase;MirTarget -0.158276071403363 0.000106857196707125 NA NA NA hsa-miR-96-5p IRS1 0.0854810872029343 0.923087820185031 -0.138887664414536 0.910081690996007 MirTarget;TargetScan;miRNATAP -0.266381208100963 1.59843806601571e-06 21993544 hsa miR 96 up regulates MAP4K1 and IRS1 and may function as a promising diagnostic marker in human bladder urothelial carcinomas; Altogether these results suggest that hsa-miR-96 may affect the growth of bladder cancer cells by up-regulating IRS1 and MAP4K1 levels functioning as a promising diagnostic marker in human bladder urothelial carcinomas bladder cancer hsa-miR-126-5p ITGA1 0.0815213541035824 0.956637332055185 0.131693058718106 0.918654113149278 mirMAP -0.198471022205304 0.0049297875119626 NA NA NA hsa-miR-1304-5p ITGA1 -0.497887681787993 0.163079003594721 0.131693058718106 0.918654113149278 MirTarget -0.16956234584519 2.2244590500633e-05 NA NA NA hsa-miR-140-5p ITGA1 -0.229213026275906 0.847330111738616 0.131693058718106 0.918654113149278 miRanda -0.22429727537473 0.00531242831457915 NA NA NA hsa-miR-141-5p ITGA1 -0.354590233549885 0.867642456336402 0.131693058718106 0.918654113149278 MirTarget -0.193885648940554 8.70347907569489e-05 NA NA NA hsa-miR-186-5p ITGA1 -0.318786974828757 0.85412722938961 0.131693058718106 0.918654113149278 mirMAP -0.383394281021098 3.85427468614133e-07 NA NA NA hsa-miR-193a-3p ITGA1 -0.247265785363732 0.654363581941634 0.131693058718106 0.918654113149278 miRanda -0.250127652085288 7.51917474800755e-07 NA NA NA hsa-miR-200a-5p ITGA1 -0.671005453811576 0.78126028567661 0.131693058718106 0.918654113149278 mirMAP -0.163512326368077 0.00112182359736555 NA NA NA hsa-miR-200b-3p ITGA1 -0.426401948379212 0.863957108574195 0.131693058718106 0.918654113149278 MirTarget -0.275261239291462 1.47993860762227e-07 NA NA NA hsa-miR-200b-5p ITGA1 -0.502275384207405 0.722255155236927 0.131693058718106 0.918654113149278 mirMAP -0.276608666997058 1.12402301111606e-08 NA NA NA hsa-miR-200c-3p ITGA1 -0.437282635857873 0.887118598436407 0.131693058718106 0.918654113149278 MirTarget -0.214226197850636 8.86362401660098e-05 NA NA NA hsa-miR-30d-3p ITGA1 -0.123474741320298 0.814905367625791 0.131693058718106 0.918654113149278 MirTarget -0.344073457921498 6.90242177396638e-09 NA NA NA hsa-miR-32-3p ITGA1 -0.568003960723004 0.13133163420273 0.131693058718106 0.918654113149278 mirMAP -0.235212901335081 8.95931721500292e-10 NA NA NA hsa-miR-330-3p ITGA1 0.00298687748748416 0.994504006750491 0.131693058718106 0.918654113149278 mirMAP -0.197642521886614 0.000960066039312917 NA NA NA hsa-miR-335-3p ITGA1 -0.244830745789445 0.88450019116631 0.131693058718106 0.918654113149278 mirMAP -0.259600849905133 1.12441405491809e-07 NA NA NA hsa-miR-335-5p ITGA1 -0.0284895175847679 0.973380867832231 0.131693058718106 0.918654113149278 miRNAWalker2_validate -0.333743288336155 3.75317759680347e-12 NA NA NA hsa-miR-361-5p ITGA1 -0.138735309928775 0.941495130308343 0.131693058718106 0.918654113149278 miRanda -0.423879973829318 3.663000282654e-06 NA NA NA hsa-miR-362-3p ITGA1 -0.721040238345347 0.0345881362485733 0.131693058718106 0.918654113149278 miRanda -0.248123075623839 1.09142801775459e-08 NA NA NA hsa-miR-374a-5p ITGA1 -0.343007247142618 0.766921280269271 0.131693058718106 0.918654113149278 mirMAP -0.305854893838573 8.55491368879254e-05 NA NA NA hsa-miR-374b-5p ITGA1 -0.285682091626878 0.83569830479965 0.131693058718106 0.918654113149278 mirMAP -0.466463602099587 2.08605791171422e-10 NA NA NA hsa-miR-421 ITGA1 -0.182032017078616 0.734704500318599 0.131693058718106 0.918654113149278 miRanda -0.195849353089713 0.000174442310488391 NA NA NA hsa-miR-429 ITGA1 -0.456485631615963 0.806240953400535 0.131693058718106 0.918654113149278 MirTarget;miRanda -0.268072135894073 1.41773513352865e-10 NA NA NA hsa-miR-452-5p ITGA1 -0.0504626418153507 0.973874641360401 0.131693058718106 0.918654113149278 mirMAP -0.152876737402724 0.00377199922835083 NA NA NA hsa-miR-548o-3p ITGA1 -0.191447572716994 0.517725546183501 0.131693058718106 0.918654113149278 mirMAP -0.16466206714245 0.000980891948942476 NA NA NA hsa-miR-576-5p ITGA1 -0.506413219377403 0.417187951364173 0.131693058718106 0.918654113149278 mirMAP -0.206927519800115 0.000149478498041825 NA NA NA hsa-miR-590-3p ITGA1 -0.279244755376859 0.59126669933662 0.131693058718106 0.918654113149278 miRanda;mirMAP -0.262034943779927 3.70569149327168e-09 NA NA NA hsa-miR-590-5p ITGA1 -0.547819833829572 0.472735645776647 0.131693058718106 0.918654113149278 miRanda;mirMAP -0.332310693189912 5.68521992837634e-13 NA NA NA hsa-miR-7-1-3p ITGA1 -0.462485777435991 0.665899751398166 0.131693058718106 0.918654113149278 mirMAP -0.187600222893559 0.00044271334940281 NA NA NA hsa-let-7g-3p ITGA10 -0.489638373791485 0.62941522205833 0.150493507652074 0.698105089207825 MirTarget;miRNATAP -0.220015945772492 0.00432409183437958 NA NA NA hsa-miR-15a-5p ITGA10 -0.0674049094129128 0.964835434214123 0.150493507652074 0.698105089207825 MirTarget -0.444362384103048 3.71101970592742e-05 NA NA NA hsa-miR-15b-5p ITGA10 -0.272614787130877 0.87096541832188 0.150493507652074 0.698105089207825 MirTarget -0.445528409311144 9.96189773437968e-06 NA NA NA hsa-miR-16-5p ITGA10 0.0135949734723564 0.994476223855607 0.150493507652074 0.698105089207825 MirTarget -0.395244149609452 9.14441899285516e-05 NA NA NA hsa-miR-28-5p ITGA10 -0.106319459230459 0.940600125491369 0.150493507652074 0.698105089207825 MirTarget;miRanda -0.656803637524575 0.00658963778501527 NA NA NA hsa-miR-30d-3p ITGA10 -0.123474741320298 0.814905367625791 0.150493507652074 0.698105089207825 mirMAP -0.414912007896224 3.09236957818315e-05 NA NA NA hsa-miR-324-5p ITGA10 -0.50063248413014 0.537416710557032 0.150493507652074 0.698105089207825 miRanda;miRNATAP -0.326056011280253 0.000582194123601929 NA NA NA hsa-miR-335-5p ITGA10 -0.0284895175847679 0.973380867832231 0.150493507652074 0.698105089207825 miRNAWalker2_validate -0.398658223246609 9.31600455062945e-07 NA NA NA hsa-miR-424-5p ITGA10 0.247080963500746 0.870154571783568 0.150493507652074 0.698105089207825 MirTarget -0.250482389494333 0.000873213192563839 NA NA NA hsa-miR-429 ITGA10 -0.456485631615963 0.806240953400535 0.150493507652074 0.698105089207825 miRanda;miRNATAP -0.450774025701731 5.21050267101495e-11 NA NA NA hsa-miR-484 ITGA10 -0.179977202691249 0.886333755572375 0.150493507652074 0.698105089207825 miRNATAP -0.537259806680491 1.29644651456166e-06 NA NA NA hsa-miR-491-3p ITGA10 -0.513850326596847 0.137836285146052 0.150493507652074 0.698105089207825 miRNATAP -0.32991904482724 1.00519284242594e-05 NA NA NA hsa-miR-491-5p ITGA10 -0.585652105321328 0.0452620602586908 0.150493507652074 0.698105089207825 MirTarget;miRanda -0.229448713150526 0.00448039900173965 NA NA NA hsa-miR-940 ITGA10 -0.225788347550697 0.680055767105815 0.150493507652074 0.698105089207825 MirTarget;miRNATAP -0.281725434264211 1.00457831874334e-05 NA NA NA hsa-miR-29a-3p ITGA11 0.01127474410284 0.996977020481272 0.414661714062807 0.710572258231175 miRNAWalker2_validate;miRTarBase -1.13141403549378 3.12157494975038e-14 NA NA NA hsa-miR-421 ITGA11 -0.182032017078616 0.734704500318599 0.414661714062807 0.710572258231175 mirMAP -0.507731718465537 7.32754975243176e-06 NA NA NA hsa-miR-429 ITGA11 -0.456485631615963 0.806240953400535 0.414661714062807 0.710572258231175 miRNATAP -0.645492709101781 8.89353667777657e-13 NA NA NA hsa-miR-532-5p ITGA11 -0.349665553500088 0.878948352437467 0.414661714062807 0.710572258231175 miRNATAP -0.411495596932655 0.000557971663551192 NA NA NA hsa-miR-130a-3p ITGA2 0.0910074087716906 0.929098200371948 -0.0348041335653395 0.981953034468536 mirMAP -0.159097679600343 0.000722482688495561 NA NA NA hsa-miR-126-5p ITGA4 0.0815213541035824 0.956637332055185 0.128409168730746 0.880442812773029 mirMAP -0.324941719968245 0.00235781982082705 NA NA NA hsa-miR-140-5p ITGA4 -0.229213026275906 0.847330111738616 0.128409168730746 0.880442812773029 miRanda -0.346626260944899 0.00447675448654936 NA NA NA hsa-miR-17-5p ITGA4 -0.175448849583061 0.934544015912731 0.128409168730746 0.880442812773029 TargetScan -0.366824320885225 2.66547752599247e-07 NA NA NA hsa-miR-30c-5p ITGA4 -0.298383882401475 0.865809030482001 0.128409168730746 0.880442812773029 miRNAWalker2_validate -0.649622994366045 1.21426381271411e-08 NA NA NA hsa-miR-320a ITGA4 -0.416546433767628 0.840202138616422 0.128409168730746 0.880442812773029 miRanda -0.303436195104732 0.00217271503234991 NA NA NA hsa-miR-320b ITGA4 -0.23561798088153 0.859222532827992 0.128409168730746 0.880442812773029 miRanda -0.291196497855819 0.00103279704198143 NA NA NA hsa-miR-339-5p ITGA4 -0.300425087100667 0.712912847076788 0.128409168730746 0.880442812773029 miRanda -0.487665788397216 4.11020064236043e-14 NA NA NA hsa-miR-362-3p ITGA4 -0.721040238345347 0.0345881362485733 0.128409168730746 0.880442812773029 miRanda -0.317274653655067 1.86331719011755e-06 NA NA NA hsa-miR-590-3p ITGA4 -0.279244755376859 0.59126669933662 0.128409168730746 0.880442812773029 miRanda -0.374320056927724 3.19212467005165e-08 NA NA NA hsa-miR-107 ITGA5 -0.0365118169251648 0.988364120226869 0.509325583435441 0.726681919262334 PITA;miRanda -0.407685902065602 0.00289030311694772 NA NA NA hsa-miR-148a-3p ITGA5 -0.101286586375016 0.976980454193186 0.509325583435441 0.726681919262334 miRNATAP -0.726222229237583 1.68300988376632e-21 NA NA NA hsa-miR-148b-3p ITGA5 -0.202106692287125 0.911884960581838 0.509325583435441 0.726681919262334 miRNAWalker2_validate -0.676177008202681 4.03461825157767e-09 27328731 Notably transendothelial migration in vitro and extravasation in vivo impaired by singly alternating miR-214 or miR-148b could be overridden by overexpression of ITGA5 or ALCAM in the same tumor cells melanoma hsa-miR-183-5p ITGA5 -0.0549974865878067 0.984855271688809 0.509325583435441 0.726681919262334 miRNAWalker2_validate -0.408050462718497 7.48906740006578e-10 NA NA NA hsa-miR-185-3p ITGA5 0.100697585937245 0.856913315942984 0.509325583435441 0.726681919262334 miRNATAP -0.282531413657642 0.000675406235942772 NA NA NA hsa-miR-193a-3p ITGA5 -0.247265785363732 0.654363581941634 0.509325583435441 0.726681919262334 miRanda -0.247694374306608 0.00113403056482098 NA NA NA hsa-miR-194-3p ITGA5 -0.614465699221301 0.733214497063146 0.509325583435441 0.726681919262334 miRNATAP -0.565695031943545 4.85111146930333e-20 NA NA NA hsa-miR-25-3p ITGA5 -0.457540448732733 0.878574066837636 0.509325583435441 0.726681919262334 miRNATAP -0.712122297572831 1.00648378831927e-10 NA NA NA hsa-miR-26a-5p ITGA5 0.00698202897993028 0.997719986197021 0.509325583435441 0.726681919262334 miRNATAP -0.630898571641941 5.55451347321823e-05 25537511 Furthermore we provide experimental evidence to confirm that ITGA5 is a bona fide target of miR-26a liver cancer hsa-miR-26b-5p ITGA5 -0.0245931278499594 0.990377966314923 0.509325583435441 0.726681919262334 miRNATAP -0.726674599135761 2.59991772375398e-12 NA NA NA hsa-miR-27a-3p ITGA5 -0.123902317731458 0.958804393510999 0.509325583435441 0.726681919262334 miRNATAP -0.462452255271056 0.000354478187101769 NA NA NA hsa-miR-27b-3p ITGA5 -0.14277121795778 0.951937409841932 0.509325583435441 0.726681919262334 miRNATAP -0.5300110652713 0.000368105625243914 NA NA NA hsa-miR-30c-5p ITGA5 -0.298383882401475 0.865809030482001 0.509325583435441 0.726681919262334 miRNATAP -0.772580491811786 1.56515554081415e-12 NA NA NA hsa-miR-30d-5p ITGA5 -0.168211838771867 0.95173197030375 0.509325583435441 0.726681919262334 miRNATAP -0.678295698471406 6.20833701704071e-12 NA NA NA hsa-miR-32-5p ITGA5 -0.05993267619119 0.952975951594959 0.509325583435441 0.726681919262334 miRNATAP -0.506622738830763 3.16669837869386e-11 NA NA NA hsa-miR-429 ITGA5 -0.456485631615963 0.806240953400535 0.509325583435441 0.726681919262334 miRNATAP -0.556783177562888 2.55152119630275e-21 NA NA NA hsa-miR-484 ITGA5 -0.179977202691249 0.886333755572375 0.509325583435441 0.726681919262334 miRNAWalker2_validate -0.520640553883533 1.64727043925306e-07 NA NA NA hsa-miR-629-3p ITGA5 -0.495402745812008 0.333967382214384 0.509325583435441 0.726681919262334 miRNATAP -0.36050120664724 1.36323895171078e-08 NA NA NA hsa-miR-760 ITGA5 -0.669469782471462 0.0773517068284613 0.509325583435441 0.726681919262334 miRNATAP -0.210742690782421 0.000145236145927548 NA NA NA hsa-miR-92a-3p ITGA5 0.0278830870766349 0.993247426671713 0.509325583435441 0.726681919262334 miRNAWalker2_validate;miRTarBase;miRNATAP -0.709254724335703 2.69256357988154e-20 23499550 The level of miR-92a expression was significantly inversely correlated with ITGA5 expression in various cancer cells; miR-92a overexpression reduced the luciferase activity of the ITGA5 3'-untranslated region suggesting that ITGA5 mRNA is a direct target of miR-92a ovarian cancer hsa-miR-98-5p ITGA5 -0.168162186023221 0.898802461503524 0.509325583435441 0.726681919262334 miRNAWalker2_validate -0.441907606838556 5.22032196692007e-05 NA NA NA hsa-miR-125b-2-3p ITGA6 -0.0782435784241886 0.894638061041299 -0.435469455539751 0.829636017201425 mirMAP -0.116338403987973 8.83881106109691e-05 NA NA NA hsa-miR-199a-3p ITGA6 0.0782166873040424 0.973766909565326 -0.435469455539751 0.829636017201425 PITA -0.16969431265799 0.00168277574298345 NA NA NA hsa-miR-199b-3p ITGA6 0.0780653337513897 0.973815251150337 -0.435469455539751 0.829636017201425 PITA -0.169632534176576 0.00168939689216214 NA NA NA hsa-miR-34c-5p ITGA6 -0.018707656771723 0.952788306178575 -0.435469455539751 0.829636017201425 miRanda -0.12061126039915 0.00747027526645092 NA NA NA hsa-miR-339-5p ITGA7 -0.300425087100667 0.712912847076788 0.265797163869632 0.745891375937802 miRanda -0.35971541507926 1.5239052481768e-07 NA NA NA hsa-miR-362-3p ITGA7 -0.721040238345347 0.0345881362485733 0.265797163869632 0.745891375937802 miRanda -0.241226253313392 0.000491544136921287 NA NA NA hsa-miR-126-5p ITGA8 0.0815213541035824 0.956637332055185 -0.452723119942728 0.408945365808624 mirMAP -0.465193641287626 0.00916619859204029 NA NA NA hsa-miR-130a-3p ITGA8 0.0910074087716906 0.929098200371948 -0.452723119942728 0.408945365808624 mirMAP -0.440025921577728 0.00210050030543243 NA NA NA hsa-miR-130b-3p ITGA8 -0.221667315324818 0.824660172394714 -0.452723119942728 0.408945365808624 mirMAP -0.756199889439761 5.72961661267263e-08 NA NA NA hsa-miR-154-3p ITGA8 -0.170366170038505 0.546500133020447 -0.452723119942728 0.408945365808624 TargetScan -0.37848072863526 0.00472164957054606 NA NA NA hsa-miR-16-1-3p ITGA8 0.151694812889216 0.733736501874638 -0.452723119942728 0.408945365808624 mirMAP -0.334016672018138 0.00624276023508538 NA NA NA hsa-miR-19b-1-5p ITGA8 -0.0105982583216702 0.988511655226679 -0.452723119942728 0.408945365808624 mirMAP -0.344200083897529 0.00715368032658121 NA NA NA hsa-miR-21-5p ITGA8 -0.148920887107433 0.970240620972126 -0.452723119942728 0.408945365808624 mirMAP -0.626770981942935 0.00758617030762763 NA NA NA hsa-miR-301a-3p ITGA8 -0.105312511901769 0.831686745977347 -0.452723119942728 0.408945365808624 mirMAP -0.344968537383022 0.00418870388547581 NA NA NA hsa-miR-30b-5p ITGA8 -0.0121430518253582 0.994622896704513 -0.452723119942728 0.408945365808624 mirMAP -0.607517013778798 6.04724828502987e-06 NA NA NA hsa-miR-30c-5p ITGA8 -0.298383882401475 0.865809030482001 -0.452723119942728 0.408945365808624 mirMAP -0.551528499023078 0.00473654681312748 NA NA NA hsa-miR-32-3p ITGA8 -0.568003960723004 0.13133163420273 -0.452723119942728 0.408945365808624 mirMAP -0.48607595614251 7.81882984800651e-07 NA NA NA hsa-miR-33a-5p ITGA8 -0.205788753603336 0.853314500865147 -0.452723119942728 0.408945365808624 mirMAP -0.317289990550241 1.81755362348727e-05 NA NA NA hsa-miR-577 ITGA8 -1.06238199218774 0.326056761787754 -0.452723119942728 0.408945365808624 mirMAP -0.212261692751436 0.00319132093721934 NA NA NA hsa-miR-590-5p ITGA8 -0.547819833829572 0.472735645776647 -0.452723119942728 0.408945365808624 mirMAP -0.677049619787042 1.27534402049843e-08 NA NA NA hsa-miR-7-1-3p ITGA8 -0.462485777435991 0.665899751398166 -0.452723119942728 0.408945365808624 mirMAP -0.38208835366898 0.00481982199526212 NA NA NA hsa-let-7f-2-3p ITGA9 -0.0455032713433074 0.882115725419367 -0.0218274991958149 0.977309334481333 mirMAP -0.312788517152204 0.00108487109431174 NA NA NA hsa-miR-141-5p ITGA9 -0.354590233549885 0.867642456336402 -0.0218274991958149 0.977309334481333 MirTarget -0.589453745206928 1.82349926223433e-09 NA NA NA hsa-miR-142-5p ITGA9 -0.118920788314118 0.929665277963083 -0.0218274991958149 0.977309334481333 mirMAP -0.277305625904923 0.00574532252500656 NA NA NA hsa-miR-194-3p ITGA9 -0.614465699221301 0.733214497063146 -0.0218274991958149 0.977309334481333 MirTarget -0.339811223759602 0.000200253814534478 NA NA NA hsa-miR-194-5p ITGA9 -0.159001168846464 0.959682382557336 -0.0218274991958149 0.977309334481333 miRNAWalker2_validate;miRTarBase -0.307223984157854 0.00260217241899569 NA NA NA hsa-miR-200b-3p ITGA9 -0.426401948379212 0.863957108574195 -0.0218274991958149 0.977309334481333 mirMAP -0.472043586834816 1.10154463072643e-05 24518294;26334393 β1 integrin inhibition elicits a prometastatic switch through the TGFβ miR 200 ZEB network in E cadherin positive triple negative breast cancer;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ; breast cancer;esophageal cancer hsa-miR-29a-5p ITGA9 -0.31835175571979 0.600442757817281 -0.0218274991958149 0.977309334481333 mirMAP -0.436426866959627 1.4131752158532e-05 26903137 We found that the up-regulation of hTERT in gastric cancer cells could inhibit the expression of miR-29a and enhance the expression of Integrin β1 ITGB1 gastric cancer hsa-miR-29b-1-5p ITGA9 -0.642348119412534 0.293891497238796 -0.0218274991958149 0.977309334481333 mirMAP -0.301555128809285 0.000128681407386433 NA NA NA hsa-miR-324-5p ITGA9 -0.50063248413014 0.537416710557032 -0.0218274991958149 0.977309334481333 miRanda -0.504215559962306 1.3799479382153e-05 NA NA NA hsa-miR-338-5p ITGA9 0.484769112400393 0.393961930708873 -0.0218274991958149 0.977309334481333 mirMAP -0.324917992038127 4.90448559632606e-05 27431198 miR 338 inhibits the metastasis of lung cancer by targeting integrin β3; Furthermore we also identified a metastasis related protein integrin β3 ITGB3 as a novel target gene of miR-338 metastasis lung cancer hsa-miR-33a-3p ITGA9 -0.794543849238581 0.0105203072007922 -0.0218274991958149 0.977309334481333 mirMAP -0.424566642266326 4.96347654464904e-06 NA NA NA hsa-miR-33a-5p ITGA9 -0.205788753603336 0.853314500865147 -0.0218274991958149 0.977309334481333 mirMAP -0.221341955961329 0.000216429427725625 NA NA NA hsa-miR-33b-5p ITGA9 -0.161971614375297 0.737436207821109 -0.0218274991958149 0.977309334481333 mirMAP -0.352749794341098 6.16759102303809e-08 NA NA NA hsa-miR-340-5p ITGA9 -0.00276909425328853 0.99757361161055 -0.0218274991958149 0.977309334481333 MirTarget;mirMAP -0.383886824877255 0.00324889370689575 NA NA NA hsa-miR-429 ITGA9 -0.456485631615963 0.806240953400535 -0.0218274991958149 0.977309334481333 miRanda -0.39279444809063 6.13224720138849e-06 NA NA NA hsa-miR-484 ITGA9 -0.179977202691249 0.886333755572375 -0.0218274991958149 0.977309334481333 miRNAWalker2_validate -0.572160816812364 3.32644195770555e-05 NA NA NA hsa-miR-576-5p ITGA9 -0.506413219377403 0.417187951364173 -0.0218274991958149 0.977309334481333 mirMAP -0.546049650520046 6.1770223548685e-07 NA NA NA hsa-miR-589-3p ITGA9 -0.835836305204965 0.0112001563801511 -0.0218274991958149 0.977309334481333 mirMAP -0.257319744472036 0.00294557739407626 NA NA NA hsa-miR-590-3p ITGA9 -0.279244755376859 0.59126669933662 -0.0218274991958149 0.977309334481333 miRanda -0.523070400204031 7.13070795449953e-09 NA NA NA hsa-miR-590-5p ITGA9 -0.547819833829572 0.472735645776647 -0.0218274991958149 0.977309334481333 miRanda -0.510845992464387 1.07139255695602e-07 NA NA NA hsa-miR-877-5p ITGA9 -0.317720731672575 0.435952264022643 -0.0218274991958149 0.977309334481333 mirMAP -0.310929749649321 0.000114129755405274 NA NA NA hsa-let-7a-3p ITGAV -0.215598045625677 0.85543299203799 0.0148858503591143 0.992317033809226 MirTarget -0.277150422479031 4.02095600400644e-08 NA NA NA hsa-let-7f-1-3p ITGAV -0.31101436822914 0.693407210545374 0.0148858503591143 0.992317033809226 MirTarget -0.353814215185426 3.22655219690122e-07 NA NA NA hsa-miR-141-3p ITGAV -0.31994058840327 0.87774106909065 0.0148858503591143 0.992317033809226 MirTarget -0.280843309664538 8.31201023763691e-14 NA NA NA hsa-miR-142-3p ITGAV -0.154235241441331 0.946098054588918 0.0148858503591143 0.992317033809226 miRNAWalker2_validate;MirTarget;PITA;miRanda;miRNATAP -0.125890722928251 0.000949939281768478 26657485 Our data identify WASL ITGAV and several additional cytoskeleton-associated molecules as novel invasion-promoting targets of miR-142-3p in breast cancer breast cancer hsa-miR-142-5p ITGAV -0.118920788314118 0.929665277963083 0.0148858503591143 0.992317033809226 MirTarget;PITA -0.117368523334994 0.00531492741002919 NA NA NA hsa-miR-16-2-3p ITGAV -0.36717860153421 0.546850726070016 0.0148858503591143 0.992317033809226 mirMAP -0.292054778424655 9.16036396213963e-13 NA NA NA hsa-miR-186-5p ITGAV -0.318786974828757 0.85412722938961 0.0148858503591143 0.992317033809226 mirMAP -0.401502775875156 2.27783156453389e-10 NA NA NA hsa-miR-192-5p ITGAV -0.117345487848223 0.972927287653137 0.0148858503591143 0.992317033809226 miRNAWalker2_validate;MirTarget -0.242063654923608 8.42765922153472e-12 NA NA NA hsa-miR-196a-5p ITGAV -0.0569856738232488 0.973093117800687 0.0148858503591143 0.992317033809226 miRNAWalker2_validate -0.138534771073409 3.53022808203241e-07 NA NA NA hsa-miR-200a-3p ITGAV -0.367034437440907 0.851059894150266 0.0148858503591143 0.992317033809226 MirTarget -0.214533194277742 1.14132593463283e-08 NA NA NA hsa-miR-25-3p ITGAV -0.457540448732733 0.878574066837636 0.0148858503591143 0.992317033809226 MirTarget;miRNATAP -0.348274359635481 5.79118554259416e-08 NA NA NA hsa-miR-29a-5p ITGAV -0.31835175571979 0.600442757817281 0.0148858503591143 0.992317033809226 mirMAP -0.332494465071513 7.38213659079592e-17 NA NA NA hsa-miR-32-5p ITGAV -0.05993267619119 0.952975951594959 0.0148858503591143 0.992317033809226 miRNAWalker2_validate;MirTarget;miRNATAP -0.322652874828122 9.56867600160528e-14 NA NA NA hsa-miR-323a-3p ITGAV 0.279126405514894 0.478782330851768 0.0148858503591143 0.992317033809226 mirMAP -0.144870340775272 0.000278442121774283 NA NA NA hsa-miR-331-5p ITGAV -0.450673082073933 0.250361590873666 0.0148858503591143 0.992317033809226 PITA -0.256436888401167 5.22822290186972e-07 NA NA NA hsa-miR-335-3p ITGAV -0.244830745789445 0.88450019116631 0.0148858503591143 0.992317033809226 MirTarget -0.236445028948565 1.19921775800172e-08 NA NA NA hsa-miR-33a-3p ITGAV -0.794543849238581 0.0105203072007922 0.0148858503591143 0.992317033809226 MirTarget -0.200237846915903 2.36531637836039e-07 NA NA NA hsa-miR-361-5p ITGAV -0.138735309928775 0.941495130308343 0.0148858503591143 0.992317033809226 MirTarget;miRanda -0.334520790333812 1.9237624103795e-05 NA NA NA hsa-miR-374a-5p ITGAV -0.343007247142618 0.766921280269271 0.0148858503591143 0.992317033809226 mirMAP -0.30805464432418 2.8916778732061e-06 NA NA NA hsa-miR-374b-5p ITGAV -0.285682091626878 0.83569830479965 0.0148858503591143 0.992317033809226 mirMAP -0.447207407668446 4.21859043970012e-13 NA NA NA hsa-miR-429 ITGAV -0.456485631615963 0.806240953400535 0.0148858503591143 0.992317033809226 miRanda -0.239679561760073 1.32095307247823e-11 NA NA NA hsa-miR-450b-5p ITGAV -0.0136687538973108 0.983149761399849 0.0148858503591143 0.992317033809226 mirMAP -0.127269259772978 0.00908744775402703 NA NA NA hsa-miR-548o-3p ITGAV -0.191447572716994 0.517725546183501 0.0148858503591143 0.992317033809226 MirTarget -0.115808334402187 0.00672384306255888 NA NA NA hsa-miR-550a-3p ITGAV -0.6199901113685 0.0836206511566976 0.0148858503591143 0.992317033809226 miRNATAP -0.236528802948371 3.19395594053961e-10 NA NA NA hsa-miR-576-5p ITGAV -0.506413219377403 0.417187951364173 0.0148858503591143 0.992317033809226 PITA;mirMAP -0.283440814330508 3.6133889997514e-10 NA NA NA hsa-miR-577 ITGAV -1.06238199218774 0.326056761787754 0.0148858503591143 0.992317033809226 mirMAP -0.156722736170554 1.75742364032384e-11 NA NA NA hsa-miR-582-3p ITGAV -0.2334649592375 0.897678119160318 0.0148858503591143 0.992317033809226 MirTarget -0.170594198889684 0.00045659315943022 NA NA NA hsa-miR-589-3p ITGAV -0.835836305204965 0.0112001563801511 0.0148858503591143 0.992317033809226 MirTarget -0.146645770534158 4.59361727809769e-05 NA NA NA hsa-miR-590-3p ITGAV -0.279244755376859 0.59126669933662 0.0148858503591143 0.992317033809226 MirTarget;PITA;miRanda -0.262301969496564 1.86869456178392e-12 NA NA NA hsa-miR-7-1-3p ITGAV -0.462485777435991 0.665899751398166 0.0148858503591143 0.992317033809226 mirMAP -0.261705180845532 3.6306129347489e-09 NA NA NA hsa-miR-92a-3p ITGAV 0.0278830870766349 0.993247426671713 0.0148858503591143 0.992317033809226 MirTarget;miRNATAP -0.292470126926276 2.9721111901259e-10 NA NA NA hsa-miR-92b-3p ITGAV -0.569866984318692 0.689321861489779 0.0148858503591143 0.992317033809226 MirTarget;miRNATAP -0.118197520836349 0.00854772812024579 NA NA NA hsa-miR-16-2-3p ITGB1 -0.36717860153421 0.546850726070016 0.27085147334283 0.895418331213463 mirMAP -0.166224949415017 2.53382892987791e-08 NA NA NA hsa-miR-186-5p ITGB1 -0.318786974828757 0.85412722938961 0.27085147334283 0.895418331213463 miRNAWalker2_validate -0.264115035184275 6.54921300348029e-09 NA NA NA hsa-miR-192-5p ITGB1 -0.117345487848223 0.972927287653137 0.27085147334283 0.895418331213463 miRNAWalker2_validate -0.158568173942199 5.16723831071796e-10 NA NA NA hsa-miR-25-3p ITGB1 -0.457540448732733 0.878574066837636 0.27085147334283 0.895418331213463 miRNAWalker2_validate -0.225943888562533 9.51654122955191e-07 NA NA NA hsa-miR-29a-3p ITGB1 0.01127474410284 0.996977020481272 0.27085147334283 0.895418331213463 MirTarget;miRNATAP -0.20104901039372 3.17927373828798e-06 26903137 hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA 29a; We found that the up-regulation of hTERT in gastric cancer cells could inhibit the expression of miR-29a and enhance the expression of Integrin β1 ITGB1; Our study also found that the restoration of miR-29a suppressed the expression of ITGB1 and inhibited GC cell metastasis both in vitro and in vivo metastasis gastric cancer hsa-miR-29b-3p ITGB1 -0.104016192263954 0.958988036765397 0.27085147334283 0.895418331213463 MirTarget;miRNATAP -0.179711862499832 2.76421553803383e-08 NA NA NA hsa-miR-374b-3p ITGB1 -0.0542885924440247 0.860753623992354 0.27085147334283 0.895418331213463 MirTarget -0.138273114132644 0.000148895813512476 NA NA NA hsa-miR-429 ITGB1 -0.456485631615963 0.806240953400535 0.27085147334283 0.895418331213463 miRanda -0.157275803618924 6.93069673379481e-10 NA NA NA hsa-miR-590-3p ITGB1 -0.279244755376859 0.59126669933662 0.27085147334283 0.895418331213463 miRanda;mirMAP -0.174687382538744 6.96678096237726e-11 NA NA NA hsa-miR-590-5p ITGB1 -0.547819833829572 0.472735645776647 0.27085147334283 0.895418331213463 miRanda -0.200988563938564 7.78052779530654e-13 NA NA NA hsa-miR-7-1-3p ITGB1 -0.462485777435991 0.665899751398166 0.27085147334283 0.895418331213463 MirTarget;mirMAP -0.157220077111398 9.25170101912241e-07 NA NA NA hsa-miR-769-5p ITGB1 -0.306614906942583 0.735704301598833 0.27085147334283 0.895418331213463 miRNAWalker2_validate -0.212386094676241 8.23687939264191e-07 NA NA NA hsa-let-7d-5p ITGB3 -0.139747701175051 0.934164162708487 0.140072224496412 0.819664412887451 MirTarget -0.98862232938171 5.6523605942055e-13 NA NA NA hsa-let-7f-5p ITGB3 0.048789917034723 0.987280455481631 0.140072224496412 0.819664412887451 MirTarget;miRNATAP -0.413704245011339 0.00255864493046051 NA NA NA hsa-let-7g-5p ITGB3 -0.200947212961157 0.922992045181955 0.140072224496412 0.819664412887451 MirTarget;miRNATAP -1.06896087020234 2.73518581765126e-16 NA NA NA hsa-miR-185-5p ITGB3 -0.294432218239008 0.820591478398594 0.140072224496412 0.819664412887451 MirTarget -0.598367106582544 1.07205184786123e-06 NA NA NA hsa-miR-186-5p ITGB3 -0.318786974828757 0.85412722938961 0.140072224496412 0.819664412887451 mirMAP -0.773066581473789 1.19787855775665e-10 NA NA NA hsa-miR-18a-3p ITGB3 -0.270443061178857 0.535291623032886 0.140072224496412 0.819664412887451 miRNATAP -0.345688114385619 3.95211123736371e-08 NA NA NA hsa-miR-1976 ITGB3 -0.283448756688618 0.707004130216603 0.140072224496412 0.819664412887451 MirTarget -0.492910544921028 1.00236617339417e-06 NA NA NA hsa-miR-221-3p ITGB3 0.0906940388127513 0.959121118272534 0.140072224496412 0.819664412887451 MirTarget -0.710113255572515 1.32511378053194e-11 NA NA NA hsa-miR-222-3p ITGB3 -0.0265849318772702 0.984005474689108 0.140072224496412 0.819664412887451 MirTarget -0.688035014679129 1.37757019532422e-13 NA NA NA hsa-miR-30b-5p ITGB3 -0.0121430518253582 0.994622896704513 0.140072224496412 0.819664412887451 mirMAP -0.607092570757011 2.36661463296638e-13 20498642 Enforced constitutive expression of mir-30 in BT-ICs inhibits their self-renewal capacity by reducing Ubc9 and induces apoptosis through silencing ITGB3 breast cancer hsa-miR-30c-5p ITGB3 -0.298383882401475 0.865809030482001 0.140072224496412 0.819664412887451 miRNAWalker2_validate;mirMAP;miRNATAP -0.742347265614626 8.35342979097882e-10 NA NA NA hsa-miR-30d-5p ITGB3 -0.168211838771867 0.95173197030375 0.140072224496412 0.819664412887451 miRNATAP -0.440457646052792 7.8997230973134e-05 NA NA NA hsa-miR-320a ITGB3 -0.416546433767628 0.840202138616422 0.140072224496412 0.819664412887451 miRanda -0.298341538010099 0.00479688176688884 NA NA NA hsa-miR-425-5p ITGB3 -0.354606074344121 0.845979106734409 0.140072224496412 0.819664412887451 MirTarget -0.614251909704281 8.64762548208889e-16 NA NA NA hsa-miR-429 ITGB3 -0.456485631615963 0.806240953400535 0.140072224496412 0.819664412887451 miRanda -0.538487733291004 2.47796129694793e-16 NA NA NA hsa-miR-542-3p ITGB3 0.188168046511374 0.909252939431573 0.140072224496412 0.819664412887451 miRanda -0.311081873123525 0.00393426831035429 NA NA NA hsa-miR-589-5p ITGB3 -0.448771545046784 0.722725226273464 0.140072224496412 0.819664412887451 MirTarget -0.673136854259535 1.43148464452071e-08 NA NA NA hsa-miR-590-3p ITGB3 -0.279244755376859 0.59126669933662 0.140072224496412 0.819664412887451 PITA;miRanda -0.559076681447848 9.1145500681935e-16 NA NA NA hsa-miR-590-5p ITGB3 -0.547819833829572 0.472735645776647 0.140072224496412 0.819664412887451 miRanda -0.675408358117766 4.24435194339168e-21 NA NA NA hsa-miR-98-5p ITGB3 -0.168162186023221 0.898802461503524 0.140072224496412 0.819664412887451 miRNAWalker2_validate;MirTarget -0.511352816479394 1.71771731358453e-05 26445551 miR 98 targets ITGB3 to inhibit proliferation migration and invasion of non small cell lung cancer; Furthermore we identified that miR-98 exerted inhibitory roles by directly binding to 3'-UTR of ITGB3 mRNA thus negatively regulated the expression of ITGB3; Interestingly upon restoring the expression of ITGB3 the effect of miR-98 on cell proliferation was partially reversed; Our findings suggest that miR-98 prevents proliferation migration and invasion of lung cancer cells by directly binding to the 3'-UTR of ITGB3 mRNA and could be a promising treatment option in anticancer therapy lung squamous cell cancer hsa-miR-532-5p ITGB4 -0.349665553500088 0.878948352437467 -0.052552124533964 0.979209566189709 miRNATAP -0.144733412138723 0.0050065832119997 NA NA NA hsa-miR-335-5p ITGB5 -0.0284895175847679 0.973380867832231 0.0736049124318834 0.964149393220888 miRNAWalker2_validate -0.132258629807668 9.12135383505763e-05 NA NA NA hsa-miR-374a-3p ITGB5 -0.118320910531011 0.958176637009264 0.0736049124318834 0.964149393220888 MirTarget -0.156569435716723 2.07553584780657e-05 NA NA NA hsa-miR-378a-5p ITGB5 -0.559739196974497 0.724882066659501 0.0736049124318834 0.964149393220888 MirTarget -0.167953714096232 7.16493524241886e-06 NA NA NA hsa-miR-421 ITGB5 -0.182032017078616 0.734704500318599 0.0736049124318834 0.964149393220888 miRanda;miRNATAP -0.14156815215293 6.06784477707069e-05 NA NA NA hsa-miR-484 ITGB5 -0.179977202691249 0.886333755572375 0.0736049124318834 0.964149393220888 miRNATAP -0.16857068233902 0.000266777002161035 NA NA NA hsa-miR-126-5p ITGB6 0.0815213541035824 0.956637332055185 0.226237509608603 0.842439957019609 MirTarget -0.345947712053616 4.02186763785815e-05 NA NA NA hsa-miR-339-5p ITGB7 -0.300425087100667 0.712912847076788 -0.383846095546966 0.631134620640613 miRanda -0.308831763390915 7.07480264250024e-05 NA NA NA hsa-miR-106a-5p ITGB8 -0.203919267842652 0.802213958426804 -0.366371436501681 0.727189882588794 MirTarget;miRNATAP -0.242025604210364 0.000794278197176789 NA NA NA hsa-miR-142-3p ITGB8 -0.154235241441331 0.946098054588918 -0.366371436501681 0.727189882588794 PITA;miRanda;miRNATAP -0.275678655425037 2.70674266773544e-06 NA NA NA hsa-miR-142-5p ITGB8 -0.118920788314118 0.929665277963083 -0.366371436501681 0.727189882588794 PITA -0.234283028249167 0.000340146950696897 NA NA NA hsa-miR-17-5p ITGB8 -0.175448849583061 0.934544015912731 -0.366371436501681 0.727189882588794 MirTarget;TargetScan;miRNATAP -0.217909599099118 0.000614312680182003 NA NA NA hsa-miR-19a-3p ITGB8 -0.206793507801887 0.844637784802316 -0.366371436501681 0.727189882588794 MirTarget -0.230916047336119 0.000127908612052839 NA NA NA hsa-miR-19b-1-5p ITGB8 -0.0105982583216702 0.988511655226679 -0.366371436501681 0.727189882588794 miRNAWalker2_validate -0.295482741432885 8.77095842288879e-06 NA NA NA hsa-miR-19b-3p ITGB8 -0.0268530183621474 0.986656783046572 -0.366371436501681 0.727189882588794 MirTarget -0.219768403357465 0.00245493452577683 NA NA NA hsa-miR-20a-5p ITGB8 -0.179153323927949 0.928118119139752 -0.366371436501681 0.727189882588794 MirTarget;miRNATAP -0.231834739222809 0.000209543195981412 NA NA NA hsa-miR-338-3p ITGB8 0.49158501750012 0.788483749194189 -0.366371436501681 0.727189882588794 miRanda -0.247884088298751 3.52701577959013e-06 NA NA NA hsa-miR-576-5p ITGB8 -0.506413219377403 0.417187951364173 -0.366371436501681 0.727189882588794 PITA -0.239628507414182 0.0010135312819739 NA NA NA hsa-miR-106b-5p JAK1 -0.297128724729339 0.869294443540749 -0.160789648998376 0.924345663738973 miRNAWalker2_validate;MirTarget -0.167053872986828 2.36141799268953e-05 NA NA NA hsa-miR-17-5p JAK1 -0.175448849583061 0.934544015912731 -0.160789648998376 0.924345663738973 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.134849334407276 7.10169984665729e-06 NA NA NA hsa-miR-20a-5p JAK1 -0.179153323927949 0.928118119139752 -0.160789648998376 0.924345663738973 MirTarget -0.116475297641578 9.02100787767039e-05 NA NA NA hsa-miR-421 JAK1 -0.182032017078616 0.734704500318599 -0.160789648998376 0.924345663738973 miRanda -0.119739376769396 0.000300534389828812 NA NA NA hsa-miR-93-5p JAK1 -0.611073677204699 0.825297877093193 -0.160789648998376 0.924345663738973 MirTarget;miRNATAP -0.109587302887753 0.00369025117895739 NA NA NA hsa-miR-193a-3p JAK2 -0.247265785363732 0.654363581941634 -0.315139147716286 0.737125845139285 miRanda -0.211938768285493 7.66190655468735e-05 NA NA NA hsa-miR-335-5p JAK2 -0.0284895175847679 0.973380867832231 -0.315139147716286 0.737125845139285 miRNAWalker2_validate -0.270984786052004 1.50549710775928e-07 NA NA NA hsa-miR-337-3p JAK2 0.226996212439783 0.815575855239318 -0.315139147716286 0.737125845139285 PITA -0.227674822763369 0.000908851990873021 NA NA NA hsa-miR-374a-5p JAK2 -0.343007247142618 0.766921280269271 -0.315139147716286 0.737125845139285 mirMAP -0.398285334749025 8.53488451380717e-07 NA NA NA hsa-miR-374b-5p JAK2 -0.285682091626878 0.83569830479965 -0.315139147716286 0.737125845139285 mirMAP -0.440177014886739 1.50417600914702e-08 NA NA NA hsa-miR-335-5p JAK3 -0.0284895175847679 0.973380867832231 -0.063598471066431 0.939287138619009 miRNAWalker2_validate -0.251562484181648 2.3085400788056e-05 NA NA NA hsa-miR-339-5p JAK3 -0.300425087100667 0.712912847076788 -0.063598471066431 0.939287138619009 miRanda -0.156762150394825 0.00353052959123591 NA NA NA hsa-miR-939-5p JAK3 -0.311196961912953 0.304447903545905 -0.063598471066431 0.939287138619009 MirTarget -0.198408127454438 0.000550081343185762 NA NA NA hsa-miR-125a-3p KDR 0.14689780893708 0.724764670752407 -0.0378454433977167 0.969000712782508 miRanda -0.135037586070917 0.00574147931378875 NA NA NA hsa-miR-149-5p KDR -0.0341785025317569 0.961061088204977 -0.0378454433977167 0.969000712782508 miRNATAP -0.17679282170212 0.000285005104916724 NA NA NA hsa-miR-15a-5p KDR -0.0674049094129128 0.964835434214123 -0.0378454433977167 0.969000712782508 miRNATAP -0.247900839321602 0.000786634287471638 NA NA NA hsa-miR-15b-5p KDR -0.272614787130877 0.87096541832188 -0.0378454433977167 0.969000712782508 miRNATAP -0.332368961924666 1.15770508385152e-06 NA NA NA hsa-miR-16-5p KDR 0.0135949734723564 0.994476223855607 -0.0378454433977167 0.969000712782508 miRTarBase;miRNATAP -0.374448057849181 3.0607960906155e-08 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-200b-3p KDR -0.426401948379212 0.863957108574195 -0.0378454433977167 0.969000712782508 miRNAWalker2_validate;miRTarBase;TargetScan -0.236585472095174 7.02568520730331e-05 NA NA NA hsa-miR-200c-3p KDR -0.437282635857873 0.887118598436407 -0.0378454433977167 0.969000712782508 miRNATAP -0.237398352198661 0.000107602125893105 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-335-5p KDR -0.0284895175847679 0.973380867832231 -0.0378454433977167 0.969000712782508 miRNAWalker2_validate -0.29736800202028 6.48712589791683e-08 NA NA NA hsa-miR-429 KDR -0.456485631615963 0.806240953400535 -0.0378454433977167 0.969000712782508 PITA;miRanda;miRNATAP -0.230423787210216 1.43465883215394e-06 NA NA NA hsa-miR-590-3p KDR -0.279244755376859 0.59126669933662 -0.0378454433977167 0.969000712782508 miRanda -0.316586357786352 1.57111917265935e-10 NA NA NA hsa-miR-590-5p KDR -0.547819833829572 0.472735645776647 -0.0378454433977167 0.969000712782508 miRanda -0.328964510777447 3.46134712737495e-10 NA NA NA hsa-let-7a-3p KIT -0.215598045625677 0.85543299203799 0.457668701771759 0.496616548931543 mirMAP -0.3809217229143 0.00182630278028915 NA NA NA hsa-let-7f-1-3p KIT -0.31101436822914 0.693407210545374 0.457668701771759 0.496616548931543 mirMAP -0.482657875905786 0.00387615090443827 NA NA NA hsa-miR-128-3p KIT -0.442192625156042 0.783886533572187 0.457668701771759 0.496616548931543 MirTarget -0.59687102544161 2.27908242272046e-05 NA NA NA hsa-miR-130b-3p KIT -0.221667315324818 0.824660172394714 0.457668701771759 0.496616548931543 miRNATAP -0.651236322715464 3.80557067482672e-09 NA NA NA hsa-miR-186-5p KIT -0.318786974828757 0.85412722938961 0.457668701771759 0.496616548931543 miRNAWalker2_validate -0.643356802872238 2.81688585045994e-05 NA NA NA hsa-miR-19a-3p KIT -0.206793507801887 0.844637784802316 0.457668701771759 0.496616548931543 miRTarBase;miRNATAP -0.500657917313782 2.31587429085004e-08 NA NA NA hsa-miR-19b-3p KIT -0.0268530183621474 0.986656783046572 0.457668701771759 0.496616548931543 miRNATAP -0.546027135667705 4.14767067130833e-07 NA NA NA hsa-miR-20a-5p KIT -0.179153323927949 0.928118119139752 0.457668701771759 0.496616548931543 miRTarBase -0.43960652214484 2.80259629126038e-06 NA NA NA hsa-miR-221-3p KIT 0.0906940388127513 0.959121118272534 0.457668701771759 0.496616548931543 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.666863756385362 6.28864219420986e-07 NA NA NA hsa-miR-222-3p KIT -0.0265849318772702 0.984005474689108 0.457668701771759 0.496616548931543 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.686230651819729 7.25180673792435e-09 NA NA NA hsa-miR-301a-3p KIT -0.105312511901769 0.831686745977347 0.457668701771759 0.496616548931543 miRNATAP -0.387224289504154 4.76195927223164e-05 NA NA NA hsa-miR-335-3p KIT -0.244830745789445 0.88450019116631 0.457668701771759 0.496616548931543 mirMAP -0.343434169049267 0.00062897018563524 NA NA NA hsa-miR-335-5p KIT -0.0284895175847679 0.973380867832231 0.457668701771759 0.496616548931543 miRNAWalker2_validate -0.366587972857823 0.000271739293378917 NA NA NA hsa-miR-421 KIT -0.182032017078616 0.734704500318599 0.457668701771759 0.496616548931543 miRanda -0.382197532209103 0.000282334300402079 NA NA NA hsa-miR-429 KIT -0.456485631615963 0.806240953400535 0.457668701771759 0.496616548931543 miRNATAP -0.373983219250199 1.48812607491237e-05 NA NA NA hsa-miR-450b-5p KIT -0.0136687538973108 0.983149761399849 0.457668701771759 0.496616548931543 MirTarget -0.383849702053645 0.000829863075234057 NA NA NA hsa-miR-454-3p KIT -0.101514866328011 0.843545158256191 0.457668701771759 0.496616548931543 miRNATAP -0.553750855301317 2.25336481948067e-05 NA NA NA hsa-miR-501-5p KIT -0.834032628506285 0.0582725160418523 0.457668701771759 0.496616548931543 miRNATAP -0.304925974412707 0.000187216847600768 NA NA NA hsa-miR-505-3p KIT -0.469094267152605 0.690382680489578 0.457668701771759 0.496616548931543 MirTarget;miRNATAP -0.680318326816466 1.74165212679761e-07 NA NA NA hsa-miR-548o-3p KIT -0.191447572716994 0.517725546183501 0.457668701771759 0.496616548931543 mirMAP -0.318295299780355 0.00158677522756669 NA NA NA hsa-miR-577 KIT -1.06238199218774 0.326056761787754 0.457668701771759 0.496616548931543 mirMAP -0.280927780359713 6.31859393201618e-07 NA NA NA hsa-miR-590-3p KIT -0.279244755376859 0.59126669933662 0.457668701771759 0.496616548931543 miRanda;mirMAP -0.443054718781092 1.02016068191292e-06 NA NA NA hsa-miR-671-5p KIT -0.373754118103105 0.411207779636977 0.457668701771759 0.496616548931543 MirTarget -0.563147306056567 5.47110754532317e-07 NA NA NA hsa-miR-17-3p KITLG 0.100221625453134 0.960113387014848 -0.562487131644406 0.618033578661231 MirTarget -0.254488454266064 5.2884195868185e-05 NA NA NA hsa-miR-181c-5p KITLG 0.042951891660695 0.969159991881861 -0.562487131644406 0.618033578661231 MirTarget -0.323428614621384 4.09391985376817e-07 NA NA NA hsa-miR-181d-5p KITLG 0.14926527647499 0.888000971478017 -0.562487131644406 0.618033578661231 MirTarget -0.244523990163924 1.08913173712828e-06 NA NA NA hsa-miR-19a-3p KITLG -0.206793507801887 0.844637784802316 -0.562487131644406 0.618033578661231 mirMAP -0.179390253452666 0.000503630652542308 NA NA NA hsa-miR-19b-3p KITLG -0.0268530183621474 0.986656783046572 -0.562487131644406 0.618033578661231 mirMAP -0.33526934290987 2.83413094765762e-08 NA NA NA hsa-miR-23a-3p KITLG -0.122198715333656 0.962717452143511 -0.562487131644406 0.618033578661231 mirMAP -0.417539718738278 0.000276840145161814 NA NA NA hsa-miR-26a-5p KITLG 0.00698202897993028 0.997719986197021 -0.562487131644406 0.618033578661231 mirMAP -0.441100932004763 0.000244345083329715 NA NA NA hsa-miR-26b-5p KITLG -0.0245931278499594 0.990377966314923 -0.562487131644406 0.618033578661231 mirMAP -0.249959830995195 0.00265203197838094 NA NA NA hsa-miR-30b-5p KITLG -0.0121430518253582 0.994622896704513 -0.562487131644406 0.618033578661231 mirMAP -0.189048907875488 0.00196626029841939 NA NA NA hsa-miR-30e-5p KITLG -0.0657075181381011 0.979684509181941 -0.562487131644406 0.618033578661231 mirMAP -0.288848961135801 0.0028871061901372 NA NA NA hsa-miR-335-3p KITLG -0.244830745789445 0.88450019116631 -0.562487131644406 0.618033578661231 MirTarget -0.201041226663142 0.00037420143920281 NA NA NA hsa-miR-374a-5p KITLG -0.343007247142618 0.766921280269271 -0.562487131644406 0.618033578661231 mirMAP -0.274429035576241 0.00203557679884464 NA NA NA hsa-miR-374b-5p KITLG -0.285682091626878 0.83569830479965 -0.562487131644406 0.618033578661231 mirMAP -0.223620629672349 0.00974897839176574 NA NA NA hsa-miR-452-3p KITLG -0.167134177977311 0.799008246175244 -0.562487131644406 0.618033578661231 mirMAP -0.139985943072296 0.0014897785492864 NA NA NA hsa-miR-126-5p KRAS 0.0815213541035824 0.956637332055185 0.0789064765134055 0.953888724941783 MirTarget -0.119864203753635 0.00133135323525602 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK pancreatic cancer hsa-miR-1271-5p KRAS -0.464440824492835 0.095633275297856 0.0789064765134055 0.953888724941783 MirTarget -0.107229521880363 7.56803548098355e-05 NA NA NA hsa-miR-181c-5p KRAS 0.042951891660695 0.969159991881861 0.0789064765134055 0.953888724941783 miRNAWalker2_validate;miRTarBase -0.100747847809848 0.000902565483936579 NA NA NA hsa-miR-199a-5p KRAS 0.157247797504494 0.935797462797012 0.0789064765134055 0.953888724941783 miRanda;miRNATAP -0.106963175847596 0.000895280762960813 NA NA NA hsa-miR-199b-5p KRAS -0.0396557270992508 0.977172718873203 0.0789064765134055 0.953888724941783 miRanda;miRNATAP -0.108743582994301 9.84561646476932e-05 27517624 The miR-199b prognostic impact was particularly evident in both younger and KRAS wild-type subgroups colorectal cancer hsa-miR-30e-5p KRAS -0.0657075181381011 0.979684509181941 0.0789064765134055 0.953888724941783 mirMAP;miRNATAP -0.119414065684219 0.00856624973196858 NA NA NA hsa-miR-181d-5p LAMA1 0.14926527647499 0.888000971478017 -0.115683468884549 0.792854606088665 MirTarget -0.275030949202356 0.00272073182112714 NA NA NA hsa-miR-421 LAMA1 -0.182032017078616 0.734704500318599 -0.115683468884549 0.792854606088665 miRNATAP -0.479428301175595 5.79273675268223e-06 NA NA NA hsa-miR-590-3p LAMA2 -0.279244755376859 0.59126669933662 -0.0548517145635294 0.948684948864514 miRanda -0.608528706224928 1.34214506640233e-09 NA NA NA hsa-miR-17-5p LAMA3 -0.175448849583061 0.934544015912731 0.100372752204148 0.945459248758904 TargetScan -0.29305667129555 0.000184194427403406 NA NA NA hsa-miR-217 LAMA3 0.341080669095094 0.760998144794468 0.100372752204148 0.945459248758904 PITA;miRanda -0.228178825380623 0.000683227489837244 NA NA NA hsa-miR-26b-5p LAMA3 -0.0245931278499594 0.990377966314923 0.100372752204148 0.945459248758904 miRNAWalker2_validate -0.347842621845639 0.00389787822371063 NA NA NA hsa-miR-188-5p LAMA4 -0.568517670542551 0.324820848307954 0.262590638086719 0.850819086081269 miRNATAP -0.296293697109862 2.96314359987781e-10 NA NA NA hsa-miR-32-3p LAMA4 -0.568003960723004 0.13133163420273 0.262590638086719 0.850819086081269 MirTarget -0.377436889082966 1.91138998214973e-17 NA NA NA hsa-miR-429 LAMA4 -0.456485631615963 0.806240953400535 0.262590638086719 0.850819086081269 miRanda -0.378787318337312 1.43227308325275e-14 NA NA NA hsa-miR-590-3p LAMA4 -0.279244755376859 0.59126669933662 0.262590638086719 0.850819086081269 miRanda -0.451669613760894 6.91122889055495e-19 NA NA NA hsa-miR-590-5p LAMA4 -0.547819833829572 0.472735645776647 0.262590638086719 0.850819086081269 MirTarget;miRanda -0.468826738089498 3.92818422070141e-18 NA NA NA hsa-miR-93-3p LAMA4 -0.438355548962673 0.549902689385444 0.262590638086719 0.850819086081269 miRNAWalker2_validate -0.442456834697495 3.18592365926003e-13 NA NA NA hsa-miR-335-5p LAMA5 -0.0284895175847679 0.973380867832231 0.386923379506125 0.794455170137157 miRNAWalker2_validate -0.390875424572914 3.71597531518378e-07 NA NA NA hsa-miR-16-5p LAMB1 0.0135949734723564 0.994476223855607 0.115278583930642 0.949058639860395 miRNAWalker2_validate -0.283717768725525 8.88492996926161e-08 NA NA NA hsa-miR-335-5p LAMB1 -0.0284895175847679 0.973380867832231 0.115278583930642 0.949058639860395 miRNAWalker2_validate -0.134141240759396 0.00232332131921703 NA NA NA hsa-miR-339-5p LAMB1 -0.300425087100667 0.712912847076788 0.115278583930642 0.949058639860395 miRanda -0.126035156782417 0.00136345681493533 NA NA NA hsa-miR-196b-5p LAMB2 -0.0840912027031901 0.972112413910242 0.00825777683914719 0.995661471613861 miRNAWalker2_validate -0.127487701325811 0.000109548516712106 NA NA NA hsa-miR-29b-1-5p LAMB2 -0.642348119412534 0.293891497238796 0.00825777683914719 0.995661471613861 MirTarget -0.301757951773071 4.77893843785674e-15 NA NA NA hsa-miR-484 LAMB2 -0.179977202691249 0.886333755572375 0.00825777683914719 0.995661471613861 miRNAWalker2_validate -0.352422217940311 5.58527018545718e-07 NA NA NA hsa-miR-10a-5p LAMC1 0.0740585720685925 0.983770933356406 0.0163796217564274 0.992289494218603 miRNAWalker2_validate -0.149516679643707 0.000235066112725927 NA NA NA hsa-miR-140-5p LAMC1 -0.229213026275906 0.847330111738616 0.0163796217564274 0.992289494218603 MirTarget;PITA;miRanda;miRNATAP -0.219201292709415 0.000432229172636842 NA NA NA hsa-miR-15a-5p LAMC1 -0.0674049094129128 0.964835434214123 0.0163796217564274 0.992289494218603 MirTarget -0.365577402561057 6.30453303764445e-14 NA NA NA hsa-miR-15b-5p LAMC1 -0.272614787130877 0.87096541832188 0.0163796217564274 0.992289494218603 MirTarget -0.273761464470099 5.24108745978082e-09 NA NA NA hsa-miR-16-5p LAMC1 0.0135949734723564 0.994476223855607 0.0163796217564274 0.992289494218603 miRNAWalker2_validate;MirTarget -0.373158944516449 1.10227349122357e-16 NA NA NA hsa-miR-182-5p LAMC1 -0.104238497940557 0.973380614062243 0.0163796217564274 0.992289494218603 miRNATAP -0.129838681721585 0.000527270173799635 NA NA NA hsa-miR-186-5p LAMC1 -0.318786974828757 0.85412722938961 0.0163796217564274 0.992289494218603 mirMAP -0.378375257870949 5.23732344145001e-11 NA NA NA hsa-miR-188-5p LAMC1 -0.568517670542551 0.324820848307954 0.0163796217564274 0.992289494218603 MirTarget -0.236153089033446 1.71673342878213e-15 NA NA NA hsa-miR-193a-3p LAMC1 -0.247265785363732 0.654363581941634 0.0163796217564274 0.992289494218603 MirTarget;PITA;miRanda -0.130118289015881 0.00112824612874283 NA NA NA hsa-miR-200b-3p LAMC1 -0.426401948379212 0.863957108574195 0.0163796217564274 0.992289494218603 MirTarget;TargetScan -0.267766683325184 2.12150247608068e-11 NA NA NA hsa-miR-200c-3p LAMC1 -0.437282635857873 0.887118598436407 0.0163796217564274 0.992289494218603 MirTarget;miRNATAP -0.226416874072552 6.35950005947023e-08 NA NA NA hsa-miR-29a-3p LAMC1 0.01127474410284 0.996977020481272 0.0163796217564274 0.992289494218603 MirTarget;miRNATAP -0.379382055972075 1.31845661810196e-12 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29b-3p LAMC1 -0.104016192263954 0.958988036765397 0.0163796217564274 0.992289494218603 MirTarget;miRNATAP -0.28977137067621 8.02357898839533e-13 NA NA NA hsa-miR-338-3p LAMC1 0.49158501750012 0.788483749194189 0.0163796217564274 0.992289494218603 MirTarget;miRanda -0.122894943990431 9.45157966222332e-05 NA NA NA hsa-miR-33a-3p LAMC1 -0.794543849238581 0.0105203072007922 0.0163796217564274 0.992289494218603 mirMAP -0.150768786656187 2.46461263812222e-05 NA NA NA hsa-miR-361-5p LAMC1 -0.138735309928775 0.941495130308343 0.0163796217564274 0.992289494218603 miRanda -0.255303792129342 0.000387857953136723 NA NA NA hsa-miR-362-3p LAMC1 -0.721040238345347 0.0345881362485733 0.0163796217564274 0.992289494218603 miRanda -0.220939746603102 3.51077744960792e-11 NA NA NA hsa-miR-374a-5p LAMC1 -0.343007247142618 0.766921280269271 0.0163796217564274 0.992289494218603 mirMAP -0.324108422333693 5.45545737046054e-08 NA NA NA hsa-miR-374b-5p LAMC1 -0.285682091626878 0.83569830479965 0.0163796217564274 0.992289494218603 mirMAP -0.366333345233466 1.36017683214174e-10 NA NA NA hsa-miR-376b-3p LAMC1 -0.00712550627858333 0.982426403308526 0.0163796217564274 0.992289494218603 MirTarget -0.115275869308777 0.00174930114884864 NA NA NA hsa-miR-424-5p LAMC1 0.247080963500746 0.870154571783568 0.0163796217564274 0.992289494218603 MirTarget;miRNATAP -0.148237178973127 2.67578333531781e-05 NA NA NA hsa-miR-429 LAMC1 -0.456485631615963 0.806240953400535 0.0163796217564274 0.992289494218603 MirTarget;PITA;miRanda;miRNATAP -0.224341837841235 3.54899655090155e-12 NA NA NA hsa-miR-452-5p LAMC1 -0.0504626418153507 0.973874641360401 0.0163796217564274 0.992289494218603 MirTarget -0.129022179851454 0.00164736734434357 NA NA NA hsa-miR-577 LAMC1 -1.06238199218774 0.326056761787754 0.0163796217564274 0.992289494218603 PITA -0.136372422104127 1.83591779280658e-10 NA NA NA hsa-miR-590-3p LAMC1 -0.279244755376859 0.59126669933662 0.0163796217564274 0.992289494218603 PITA;miRanda;mirMAP -0.266944210678875 1.59712831379427e-15 NA NA NA hsa-miR-642a-5p LAMC1 0.00605485088835034 0.98806034007652 0.0163796217564274 0.992289494218603 MirTarget -0.115061536946357 3.56638849385997e-05 NA NA NA hsa-miR-7-1-3p LAMC1 -0.462485777435991 0.665899751398166 0.0163796217564274 0.992289494218603 mirMAP -0.225517984150294 3.00088890172366e-08 NA NA NA hsa-miR-92a-3p LAMC1 0.0278830870766349 0.993247426671713 0.0163796217564274 0.992289494218603 miRNAWalker2_validate -0.268569334768111 2.33219095337538e-10 NA NA NA hsa-miR-942-5p LAMC1 -0.50502396741886 0.50777904281306 0.0163796217564274 0.992289494218603 MirTarget -0.249626526491709 9.76370828110307e-14 NA NA NA hsa-miR-96-5p LAMC1 0.0854810872029343 0.923087820185031 0.0163796217564274 0.992289494218603 MirTarget;TargetScan;miRNATAP -0.221569652587064 3.6145190516014e-10 NA NA NA hsa-miR-98-5p LAMC1 -0.168162186023221 0.898802461503524 0.0163796217564274 0.992289494218603 miRNAWalker2_validate -0.254049883065039 8.73611506964667e-06 NA NA NA hsa-miR-421 LAMC2 -0.182032017078616 0.734704500318599 0.101266309680676 0.954267964962389 miRanda -0.239500562082928 0.000103488568683706 NA NA NA hsa-miR-590-5p LAMC2 -0.547819833829572 0.472735645776647 0.101266309680676 0.954267964962389 miRanda -0.159901268461205 0.0052875199716673 NA NA NA hsa-miR-660-5p LAMC2 -0.476129334484339 0.694082832658925 0.101266309680676 0.954267964962389 MirTarget -0.266323708518325 5.6846429737507e-05 NA NA NA hsa-miR-7-5p LAMC2 0.209645143210379 0.773705612298441 0.101266309680676 0.954267964962389 miRNAWalker2_validate -0.151062771183923 0.000180005397789752 NA NA NA hsa-miR-130b-3p LAMC3 -0.221667315324818 0.824660172394714 -0.311113138059067 0.52841217126036 mirMAP -0.390297993114714 0.00133097121952445 NA NA NA hsa-let-7f-1-3p LPAR1 -0.31101436822914 0.693407210545374 0.248468548222185 0.70253888432153 mirMAP -0.538128835088781 3.81586712081023e-05 NA NA NA hsa-miR-16-2-3p LPAR1 -0.36717860153421 0.546850726070016 0.248468548222185 0.70253888432153 MirTarget;mirMAP -0.25678457740096 0.00131414233610344 NA NA NA hsa-miR-188-5p LPAR1 -0.568517670542551 0.324820848307954 0.248468548222185 0.70253888432153 MirTarget -0.309837897501073 1.01338641866112e-06 NA NA NA hsa-miR-200b-3p LPAR1 -0.426401948379212 0.863957108574195 0.248468548222185 0.70253888432153 MirTarget;TargetScan -0.388893130235479 3.58413471429069e-06 NA NA NA hsa-miR-200c-3p LPAR1 -0.437282635857873 0.887118598436407 0.248468548222185 0.70253888432153 miRNAWalker2_validate;MirTarget;miRNATAP -0.41366470430554 1.59986820080516e-06 NA NA NA hsa-miR-20a-3p LPAR1 0.456808229166028 0.57674056136504 0.248468548222185 0.70253888432153 MirTarget -0.255446300513313 2.25524237986405e-05 NA NA NA hsa-miR-23a-3p LPAR1 -0.122198715333656 0.962717452143511 0.248468548222185 0.70253888432153 MirTarget;miRNATAP -0.529753131087208 0.00103304727634081 NA NA NA hsa-miR-26b-5p LPAR1 -0.0245931278499594 0.990377966314923 0.248468548222185 0.70253888432153 miRNATAP -0.355780402451559 0.00227157784661864 NA NA NA hsa-miR-32-3p LPAR1 -0.568003960723004 0.13133163420273 0.248468548222185 0.70253888432153 mirMAP -0.262659098542335 2.60513328014613e-05 NA NA NA hsa-miR-324-5p LPAR1 -0.50063248413014 0.537416710557032 0.248468548222185 0.70253888432153 miRanda -0.443531758414527 9.1306616698829e-07 NA NA NA hsa-miR-335-3p LPAR1 -0.244830745789445 0.88450019116631 0.248468548222185 0.70253888432153 mirMAP -0.373954231054767 1.80196504430466e-06 NA NA NA hsa-miR-339-5p LPAR1 -0.300425087100667 0.712912847076788 0.248468548222185 0.70253888432153 miRanda -0.347950362991192 7.20930506178312e-07 NA NA NA hsa-miR-361-5p LPAR1 -0.138735309928775 0.941495130308343 0.248468548222185 0.70253888432153 miRanda -0.443875271346448 0.00266009327646164 NA NA NA hsa-miR-374b-5p LPAR1 -0.285682091626878 0.83569830479965 0.248468548222185 0.70253888432153 MirTarget -0.464266174662141 0.000111811675119121 NA NA NA hsa-miR-421 LPAR1 -0.182032017078616 0.734704500318599 0.248468548222185 0.70253888432153 miRanda -0.373018200345766 6.02314277780491e-06 NA NA NA hsa-miR-429 LPAR1 -0.456485631615963 0.806240953400535 0.248468548222185 0.70253888432153 MirTarget;miRanda;miRNATAP -0.354384672398914 1.52919312226977e-07 NA NA NA hsa-miR-452-5p LPAR1 -0.0504626418153507 0.973874641360401 0.248468548222185 0.70253888432153 MirTarget -0.278562395451289 0.00087673063543801 NA NA NA hsa-miR-501-5p LPAR1 -0.834032628506285 0.0582725160418523 0.248468548222185 0.70253888432153 MirTarget;miRNATAP -0.254724994983656 7.4876540558711e-05 NA NA NA hsa-miR-576-5p LPAR1 -0.506413219377403 0.417187951364173 0.248468548222185 0.70253888432153 mirMAP -0.332971977522467 0.000124866243410113 NA NA NA hsa-miR-671-5p LPAR1 -0.373754118103105 0.411207779636977 0.248468548222185 0.70253888432153 MirTarget -0.340844511573604 0.000148357879764883 NA NA NA hsa-miR-7-1-3p LPAR1 -0.462485777435991 0.665899751398166 0.248468548222185 0.70253888432153 MirTarget -0.28233211661746 0.000906585389662745 NA NA NA hsa-miR-143-3p LPAR2 0.371591944134735 0.927341352649583 0.000320810073699995 0.999751392281419 miRNATAP -0.190315269910427 6.36771230241007e-07 NA NA NA hsa-miR-590-3p LPAR6 -0.279244755376859 0.59126669933662 0.318860075803941 0.707531696975123 miRanda -0.189655902717911 0.00200573297737798 NA NA NA hsa-miR-101-3p MAP2K1 0.0107754887734437 0.997036362636866 -0.0827143668416932 0.951976704641412 miRNAWalker2_validate -0.184567516398963 1.51165586105245e-05 NA NA NA hsa-miR-34c-5p MAP2K1 -0.018707656771723 0.952788306178575 -0.0827143668416932 0.951976704641412 PITA;miRanda -0.110947114920215 0.000102476815991688 NA NA NA hsa-miR-497-5p MAP2K1 -0.0120217191428731 0.989147225742026 -0.0827143668416932 0.951976704641412 miRNAWalker2_validate -0.154029164580327 9.63370868318467e-06 NA NA NA hsa-miR-106a-5p MCL1 -0.203919267842652 0.802213958426804 0.031780573638537 0.986832849533476 MirTarget;miRNATAP -0.115192461006802 0.00115373844030791 23904379 MiR 106a targets Mcl 1 to suppress cisplatin resistance of ovarian cancer A2780 cells; Real-time PCR Western blotting and luciferase reporter assay were applied to explore whether Mcl-1 was a target of miR-106a; Furthermore miR-106a inhibited cell survival and cisplatin resistance through downregulating the expression of Mcl-1; Mcl-1 was a direct target of miR-106a; These results suggest that miR-106a may provide a novel mechanism for understanding cisplatin resistance in ovarian cancer by modulating Mcl-1 drug resistance;poor survival ovarian cancer hsa-miR-106b-5p MCL1 -0.297128724729339 0.869294443540749 0.031780573638537 0.986832849533476 MirTarget;miRNATAP -0.150024160732791 0.000245227497908669 NA NA NA hsa-miR-151a-3p MCL1 -0.0829874640636401 0.975334671097605 0.031780573638537 0.986832849533476 miRNAWalker2_validate -0.154595068684777 0.00304141723372093 NA NA NA hsa-miR-17-5p MCL1 -0.175448849583061 0.934544015912731 0.031780573638537 0.986832849533476 MirTarget;TargetScan;miRNATAP -0.150824064502648 9.75163196191874e-07 NA NA NA hsa-miR-20a-5p MCL1 -0.179153323927949 0.928118119139752 0.031780573638537 0.986832849533476 MirTarget;miRNATAP -0.134204841900857 1.08514976539518e-05 23594563 Subsequent investigations revealed that miR-20a directly targeted myeloid cell leukemia sequence 1 Mcl-1 and reduced the endogenous protein level of Mcl-1 in HCC cells liver cancer hsa-miR-335-3p MCL1 -0.244830745789445 0.88450019116631 0.031780573638537 0.986832849533476 mirMAP -0.170194163719019 1.00304654750776e-07 NA NA NA hsa-miR-361-5p MCL1 -0.138735309928775 0.941495130308343 0.031780573638537 0.986832849533476 miRanda -0.221074463347132 0.00024904689705947 NA NA NA hsa-miR-93-5p MCL1 -0.611073677204699 0.825297877093193 0.031780573638537 0.986832849533476 MirTarget;miRNATAP -0.121692558062425 0.00171940187894295 NA NA NA hsa-miR-143-3p MDM2 0.371591944134735 0.927341352649583 -0.485742577574077 0.723491564717608 miRNAWalker2_validate -0.16317524344501 0.00124362026384159 NA NA NA hsa-miR-411-3p MET 0.067548244516879 0.817862200003413 -0.125950869647744 0.941487193750405 mirMAP -0.145209786605774 0.000849690466844978 NA NA NA hsa-miR-139-5p MYB -0.0810891026597322 0.928690377743652 -0.565828218697896 0.704717147712169 miRanda -0.178238981381793 0.00389025325317348 NA NA NA hsa-miR-320b MYC -0.23561798088153 0.859222532827992 -0.445372871610816 0.811492365164222 miRNAWalker2_validate -0.243607030835589 0.000321638494084035 26487644 miR 320b suppresses cell proliferation by targeting c Myc in human colorectal cancer cells; Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo while c-MYC was identified as a target gene of miR-320b in CRC; Furthermore it was found that up-regulation of c-Myc can attenuate the effects induced by miR-320b; Our identification of c-MYC as a target gene of miR-320b provides new insights into the pathophysiology of CRC proliferation and identifies miR-320b as a novel therapeutic target for the treatment of CRC colorectal cancer hsa-miR-10a-5p NGFR 0.0740585720685925 0.983770933356406 0.885325062003582 0.109115924574322 mirMAP -0.57553024334957 1.92818293620859e-05 NA NA NA hsa-miR-1275 NGFR -0.831342050607648 0.0803795852164229 0.885325062003582 0.109115924574322 mirMAP -0.287453379390587 0.00128898690353953 NA NA NA hsa-miR-148b-5p NGFR -0.236618793990305 0.43925706879726 0.885325062003582 0.109115924574322 mirMAP -0.797182921842956 2.03014337148425e-10 NA NA NA hsa-miR-15b-3p NGFR -0.557749208157585 0.609181305423188 0.885325062003582 0.109115924574322 mirMAP -1.18491650130189 2.46469294337687e-18 NA NA NA hsa-miR-185-3p NGFR 0.100697585937245 0.856913315942984 0.885325062003582 0.109115924574322 miRNATAP -0.544724292922665 0.000171239589639738 NA NA NA hsa-miR-188-3p NGFR -0.292769686102066 0.475019668859617 0.885325062003582 0.109115924574322 miRNATAP -0.287678324927274 0.00325153363678258 NA NA NA hsa-miR-194-3p NGFR -0.614465699221301 0.733214497063146 0.885325062003582 0.109115924574322 mirMAP -0.940071205248558 6.75747841363716e-18 NA NA NA hsa-miR-2110 NGFR -0.317803483266315 0.250981343062022 0.885325062003582 0.109115924574322 mirMAP -0.491241068229864 0.000339574940265899 NA NA NA hsa-miR-27a-3p NGFR -0.123902317731458 0.958804393510999 0.885325062003582 0.109115924574322 miRNATAP -1.0940953452606 9.94470304770235e-07 NA NA NA hsa-miR-27b-3p NGFR -0.14277121795778 0.951937409841932 0.885325062003582 0.109115924574322 miRNATAP -0.675601576854565 0.00993380464009985 NA NA NA hsa-miR-30b-3p NGFR -0.514644352757504 0.162424853398397 0.885325062003582 0.109115924574322 mirMAP -0.70781693831942 1.60016615876343e-07 NA NA NA hsa-miR-324-5p NGFR -0.50063248413014 0.537416710557032 0.885325062003582 0.109115924574322 miRanda -0.774531921077593 1.24999990242102e-07 NA NA NA hsa-miR-335-5p NGFR -0.0284895175847679 0.973380867832231 0.885325062003582 0.109115924574322 miRNAWalker2_validate -0.582671549958343 5.70354295101825e-06 NA NA NA hsa-miR-34a-5p NGFR -0.50188164870224 0.742034237185732 0.885325062003582 0.109115924574322 mirMAP -0.522596685783366 0.000556195990483505 NA NA NA hsa-miR-429 NGFR -0.456485631615963 0.806240953400535 0.885325062003582 0.109115924574322 miRNATAP -0.906240637466081 3.75014454803432e-18 NA NA NA hsa-miR-539-5p NGFR 0.124342970087029 0.801067485473643 0.885325062003582 0.109115924574322 mirMAP -0.529908329584141 0.000657204445329763 NA NA NA hsa-miR-625-5p NGFR -0.690759472145277 0.210306534567564 0.885325062003582 0.109115924574322 mirMAP -0.638805845344215 2.21297400348686e-10 NA NA NA hsa-miR-760 NGFR -0.669469782471462 0.0773517068284613 0.885325062003582 0.109115924574322 miRNATAP -0.329941574602725 0.000700846491603416 NA NA NA hsa-miR-429 NOS3 -0.456485631615963 0.806240953400535 0.395460306738068 0.688092154245409 miRanda -0.151439051643812 0.00309522842297632 NA NA NA hsa-let-7e-5p NRAS 0.211156073215582 0.922335699862928 -0.124828619880436 0.932579310697412 MirTarget;miRNATAP -0.13435195257722 0.00396667581188335 NA NA NA hsa-miR-221-3p NTF3 0.0906940388127513 0.959121118272534 -0.257089163862745 0.636332266772515 miRNATAP -0.610109014654345 2.67344459535098e-07 NA NA NA hsa-miR-222-3p NTF3 -0.0265849318772702 0.984005474689108 -0.257089163862745 0.636332266772515 miRNATAP -0.52313575472335 8.7686929594132e-07 NA NA NA hsa-miR-335-5p NTF3 -0.0284895175847679 0.973380867832231 -0.257089163862745 0.636332266772515 miRNAWalker2_validate -0.254297552536586 0.00467425364710777 NA NA NA hsa-miR-590-3p NTF3 -0.279244755376859 0.59126669933662 -0.257089163862745 0.636332266772515 miRanda -0.238867138855125 0.00352466395294062 NA NA NA hsa-miR-590-5p NTF3 -0.547819833829572 0.472735645776647 -0.257089163862745 0.636332266772515 PITA;miRanda;miRNATAP -0.282294314485261 0.0010790491435192 NA NA NA hsa-miR-130b-3p NTRK2 -0.221667315324818 0.824660172394714 0.713957410525928 0.344227464503002 mirMAP -0.84860306305913 3.68116891250849e-06 NA NA NA hsa-miR-130b-5p NTRK2 -0.6472141103776 0.379096015222509 0.713957410525928 0.344227464503002 mirMAP -0.818046242261116 2.04435381224772e-06 NA NA NA hsa-miR-148a-5p NTRK2 -0.448099743845604 0.748419139652266 0.713957410525928 0.344227464503002 mirMAP -0.470909045599969 0.00866907323410485 NA NA NA hsa-miR-151a-5p NTRK2 -0.416333535986492 0.695673384848773 0.713957410525928 0.344227464503002 miRNATAP -0.798069900850692 3.15200099909301e-05 NA NA NA hsa-miR-15b-3p NTRK2 -0.557749208157585 0.609181305423188 0.713957410525928 0.344227464503002 mirMAP -1.03701612899491 9.73522451080546e-09 NA NA NA hsa-miR-17-3p NTRK2 0.100221625453134 0.960113387014848 0.713957410525928 0.344227464503002 miRNATAP -0.976533297109227 5.8165830360126e-08 NA NA NA hsa-miR-185-5p NTRK2 -0.294432218239008 0.820591478398594 0.713957410525928 0.344227464503002 mirMAP -0.779623016009143 0.0021334075140637 NA NA NA hsa-miR-186-5p NTRK2 -0.318786974828757 0.85412722938961 0.713957410525928 0.344227464503002 mirMAP -0.957383701195755 0.000144839968612385 NA NA NA hsa-miR-200c-3p NTRK2 -0.437282635857873 0.887118598436407 0.713957410525928 0.344227464503002 miRNAWalker2_validate;miRTarBase -0.6199899985899 0.000602799134319623 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-20a-3p NTRK2 0.456808229166028 0.57674056136504 0.713957410525928 0.344227464503002 mirMAP -0.60033772601526 1.28938210177587e-06 NA NA NA hsa-miR-301a-3p NTRK2 -0.105312511901769 0.831686745977347 0.713957410525928 0.344227464503002 mirMAP -0.59702518092561 0.00012887559022196 NA NA NA hsa-miR-30b-5p NTRK2 -0.0121430518253582 0.994622896704513 0.713957410525928 0.344227464503002 mirMAP -0.518136651655039 0.00350366761608414 NA NA NA hsa-miR-30d-3p NTRK2 -0.123474741320298 0.814905367625791 0.713957410525928 0.344227464503002 mirMAP -0.75947148446546 0.000144661247180184 NA NA NA hsa-miR-32-3p NTRK2 -0.568003960723004 0.13133163420273 0.713957410525928 0.344227464503002 mirMAP -0.393955653385373 0.00254657240224691 NA NA NA hsa-miR-32-5p NTRK2 -0.05993267619119 0.952975951594959 0.713957410525928 0.344227464503002 mirMAP -0.593687529017976 0.00074047888176755 NA NA NA hsa-miR-335-3p NTRK2 -0.244830745789445 0.88450019116631 0.713957410525928 0.344227464503002 mirMAP -0.586164490861426 0.000350559482261675 NA NA NA hsa-miR-33a-5p NTRK2 -0.205788753603336 0.853314500865147 0.713957410525928 0.344227464503002 mirMAP -0.440166951806151 4.80538013717642e-06 NA NA NA hsa-miR-33b-5p NTRK2 -0.161971614375297 0.737436207821109 0.713957410525928 0.344227464503002 mirMAP -0.346053614022834 0.00134849656880221 NA NA NA hsa-miR-369-3p NTRK2 0.116576891957687 0.83230082995912 0.713957410525928 0.344227464503002 mirMAP -0.51441210411069 0.00545821172882658 NA NA NA hsa-miR-374a-5p NTRK2 -0.343007247142618 0.766921280269271 0.713957410525928 0.344227464503002 mirMAP -0.792957457071796 0.00213131427236809 NA NA NA hsa-miR-377-3p NTRK2 -0.0435868040110954 0.893514136702459 0.713957410525928 0.344227464503002 mirMAP -0.469186765032496 0.00325676657980703 NA NA NA hsa-miR-421 NTRK2 -0.182032017078616 0.734704500318599 0.713957410525928 0.344227464503002 mirMAP -0.745837972793792 1.27502759209042e-05 NA NA NA hsa-miR-429 NTRK2 -0.456485631615963 0.806240953400535 0.713957410525928 0.344227464503002 PITA;miRanda;miRNATAP -0.607358789765713 1.69318009529954e-05 NA NA NA hsa-miR-452-3p NTRK2 -0.167134177977311 0.799008246175244 0.713957410525928 0.344227464503002 mirMAP -0.424826514888043 0.000882386795086219 NA NA NA hsa-miR-454-3p NTRK2 -0.101514866328011 0.843545158256191 0.713957410525928 0.344227464503002 mirMAP -1.03687565563906 1.01741231251894e-06 NA NA NA hsa-miR-455-3p NTRK2 -0.356341681711462 0.824635754440661 0.713957410525928 0.344227464503002 mirMAP -0.435834708344416 0.00407925932571666 NA NA NA hsa-miR-501-5p NTRK2 -0.834032628506285 0.0582725160418523 0.713957410525928 0.344227464503002 mirMAP -0.388955969272554 0.00376398178826822 NA NA NA hsa-miR-576-5p NTRK2 -0.506413219377403 0.417187951364173 0.713957410525928 0.344227464503002 PITA;mirMAP -0.620750548380737 0.000573279730246138 NA NA NA hsa-miR-577 NTRK2 -1.06238199218774 0.326056761787754 0.713957410525928 0.344227464503002 mirMAP -0.394769227040369 2.13251966281415e-05 NA NA NA hsa-miR-590-3p NTRK2 -0.279244755376859 0.59126669933662 0.713957410525928 0.344227464503002 PITA;miRanda;mirMAP -0.650284146592079 1.26751543217643e-05 NA NA NA hsa-miR-590-5p NTRK2 -0.547819833829572 0.472735645776647 0.713957410525928 0.344227464503002 miRanda;mirMAP -0.801561087461349 2.88717365367254e-07 NA NA NA hsa-miR-760 NTRK2 -0.669469782471462 0.0773517068284613 0.713957410525928 0.344227464503002 PITA;miRNATAP -0.320637386396562 0.00994890145462774 NA NA NA hsa-miR-940 NTRK2 -0.225788347550697 0.680055767105815 0.713957410525928 0.344227464503002 PITA -0.53900674685054 2.49123954783046e-05 NA NA NA hsa-miR-320a OSM -0.416546433767628 0.840202138616422 0.103691819182827 0.857370320646043 miRanda -0.415784695239775 0.00500697105310872 NA NA NA hsa-miR-320b OSM -0.23561798088153 0.859222532827992 0.103691819182827 0.857370320646043 miRanda -0.384912126448891 0.00378887698133171 NA NA NA hsa-miR-590-5p OSM -0.547819833829572 0.472735645776647 0.103691819182827 0.857370320646043 miRanda -0.306364153276096 0.0052331892512604 NA NA NA hsa-miR-592 OSM -0.177670083168544 0.856226890424691 0.103691819182827 0.857370320646043 PITA;miRNATAP -0.237137669046186 4.18378842780268e-06 NA NA NA hsa-let-7d-5p OSMR -0.139747701175051 0.934164162708487 0.00216857550159144 0.997923739247632 miRNATAP -1.07184151663715 6.00910861679442e-10 NA NA NA hsa-let-7f-5p OSMR 0.048789917034723 0.987280455481631 0.00216857550159144 0.997923739247632 miRNATAP -0.44457171804473 0.00933859815437153 NA NA NA hsa-let-7g-5p OSMR -0.200947212961157 0.922992045181955 0.00216857550159144 0.997923739247632 miRNATAP -1.19222774082954 5.12587563574093e-13 NA NA NA hsa-miR-1254 OSMR -0.488929355953681 0.19551794273322 0.00216857550159144 0.997923739247632 MirTarget -0.243454875322682 0.00552273139839542 NA NA NA hsa-miR-140-5p OSMR -0.229213026275906 0.847330111738616 0.00216857550159144 0.997923739247632 miRanda -0.443103270757812 0.00620788358919925 NA NA NA hsa-miR-193a-3p OSMR -0.247265785363732 0.654363581941634 0.00216857550159144 0.997923739247632 MirTarget -0.462314056207244 6.02581189406899e-06 NA NA NA hsa-miR-193b-3p OSMR 0.0672068426635715 0.951480422273678 0.00216857550159144 0.997923739247632 MirTarget -0.326643136707499 0.0014350882627309 NA NA NA hsa-miR-196a-5p OSMR -0.0569856738232488 0.973093117800687 0.00216857550159144 0.997923739247632 miRNATAP -0.373031573939587 4.56224308368547e-09 NA NA NA hsa-miR-196b-5p OSMR -0.0840912027031901 0.972112413910242 0.00216857550159144 0.997923739247632 miRNATAP -0.267627808268696 2.24946543544286e-05 NA NA NA hsa-miR-200b-3p OSMR -0.426401948379212 0.863957108574195 0.00216857550159144 0.997923739247632 TargetScan -0.766740801405702 5.78056820519088e-14 NA NA NA hsa-miR-335-5p OSMR -0.0284895175847679 0.973380867832231 0.00216857550159144 0.997923739247632 miRNAWalker2_validate -0.804135889957567 1.24599716554332e-17 NA NA NA hsa-miR-362-3p OSMR -0.721040238345347 0.0345881362485733 0.00216857550159144 0.997923739247632 miRanda -0.498074042481894 1.17761277129869e-08 NA NA NA hsa-miR-374a-5p OSMR -0.343007247142618 0.766921280269271 0.00216857550159144 0.997923739247632 mirMAP -0.651406063414268 3.06926852708041e-05 NA NA NA hsa-miR-374b-5p OSMR -0.285682091626878 0.83569830479965 0.00216857550159144 0.997923739247632 mirMAP -0.903856112723366 1.06191708297857e-09 NA NA NA hsa-miR-429 OSMR -0.456485631615963 0.806240953400535 0.00216857550159144 0.997923739247632 miRanda;miRNATAP -0.689001426037846 2.34458971033647e-17 NA NA NA hsa-miR-548o-3p OSMR -0.191447572716994 0.517725546183501 0.00216857550159144 0.997923739247632 MirTarget -0.304670977491603 0.0024799725697717 NA NA NA hsa-miR-590-3p OSMR -0.279244755376859 0.59126669933662 0.00216857550159144 0.997923739247632 miRanda;mirMAP;miRNATAP -0.679900270729969 4.79037887247072e-15 NA NA NA hsa-miR-98-5p OSMR -0.168162186023221 0.898802461503524 0.00216857550159144 0.997923739247632 miRNAWalker2_validate -0.65184790597328 1.02842987099591e-05 NA NA NA hsa-miR-331-5p PDGFA -0.450673082073933 0.250361590873666 0.322821100258507 0.767865638706571 PITA;miRNATAP -0.263950239852047 0.000506838266187203 NA NA NA hsa-let-7d-5p PDGFB -0.139747701175051 0.934164162708487 0.313242927790498 0.743141773305227 miRNATAP -0.35910919131 0.000104487041240393 NA NA NA hsa-let-7f-5p PDGFB 0.048789917034723 0.987280455481631 0.313242927790498 0.743141773305227 miRNATAP -0.244280289349921 0.00604928509607363 NA NA NA hsa-let-7g-5p PDGFB -0.200947212961157 0.922992045181955 0.313242927790498 0.743141773305227 miRNATAP -0.480991322593709 4.82276901946855e-08 NA NA NA hsa-miR-17-5p PDGFB -0.175448849583061 0.934544015912731 0.313242927790498 0.743141773305227 TargetScan -0.259524570506942 1.31684333799908e-07 NA NA NA hsa-miR-18a-3p PDGFB -0.270443061178857 0.535291623032886 0.313242927790498 0.743141773305227 MirTarget -0.122279258136473 0.00341292486566504 NA NA NA hsa-miR-26b-5p PDGFB -0.0245931278499594 0.990377966314923 0.313242927790498 0.743141773305227 miRNAWalker2_validate -0.347387618826242 4.49913892640547e-06 NA NA NA hsa-miR-29a-3p PDGFB 0.01127474410284 0.996977020481272 0.313242927790498 0.743141773305227 MirTarget;miRNATAP -0.288293585647454 0.000119375011677654 NA NA NA hsa-miR-29b-3p PDGFB -0.104016192263954 0.958988036765397 0.313242927790498 0.743141773305227 MirTarget;miRNATAP -0.241085738055695 2.00161076900261e-05 NA NA NA hsa-miR-335-5p PDGFB -0.0284895175847679 0.973380867832231 0.313242927790498 0.743141773305227 mirMAP -0.290025221620047 1.51950551363649e-08 NA NA NA hsa-miR-362-3p PDGFB -0.721040238345347 0.0345881362485733 0.313242927790498 0.743141773305227 miRanda -0.15824200229485 0.000678732510299074 NA NA NA hsa-miR-590-3p PDGFB -0.279244755376859 0.59126669933662 0.313242927790498 0.743141773305227 PITA;miRanda;miRNATAP -0.253879073321591 5.92294321424903e-08 NA NA NA hsa-let-7a-3p PDGFC -0.215598045625677 0.85543299203799 0.414252063165922 0.616833473868723 mirMAP -0.560183588702006 8.86071239448277e-09 NA NA NA hsa-let-7f-1-3p PDGFC -0.31101436822914 0.693407210545374 0.414252063165922 0.616833473868723 mirMAP -0.703978074740073 1.42987121597363e-07 NA NA NA hsa-miR-142-5p PDGFC -0.118920788314118 0.929665277963083 0.414252063165922 0.616833473868723 PITA -0.305943205742333 0.000155995351628435 NA NA NA hsa-miR-16-2-3p PDGFC -0.36717860153421 0.546850726070016 0.414252063165922 0.616833473868723 mirMAP -0.645615500315815 8.74884490838483e-17 NA NA NA hsa-miR-335-3p PDGFC -0.244830745789445 0.88450019116631 0.414252063165922 0.616833473868723 mirMAP -0.427906675686462 1.13976939151158e-07 NA NA NA hsa-miR-340-5p PDGFC -0.00276909425328853 0.99757361161055 0.414252063165922 0.616833473868723 mirMAP -0.317325095486823 0.00272400287013771 NA NA NA hsa-miR-361-5p PDGFC -0.138735309928775 0.941495130308343 0.414252063165922 0.616833473868723 miRanda -0.400399039684502 0.00909721956142468 NA NA NA hsa-miR-374a-3p PDGFC -0.118320910531011 0.958176637009264 0.414252063165922 0.616833473868723 mirMAP -0.298503375227624 0.000932648117099459 NA NA NA hsa-miR-375 PDGFC -0.690952835064582 0.831716365337668 0.414252063165922 0.616833473868723 miRNAWalker2_validate;miRanda -0.245562483628609 1.4753224001304e-05 NA NA NA hsa-miR-421 PDGFC -0.182032017078616 0.734704500318599 0.414252063165922 0.616833473868723 miRanda -0.371118134754982 1.45046027428591e-05 NA NA NA hsa-miR-486-5p PDGFC -0.547739229538641 0.696404149927963 0.414252063165922 0.616833473868723 miRanda -0.212861950777362 0.000436948085668591 NA NA NA hsa-miR-582-3p PDGFC -0.2334649592375 0.897678119160318 0.414252063165922 0.616833473868723 PITA -0.419807549483108 6.92645904555322e-06 NA NA NA hsa-miR-590-3p PDGFC -0.279244755376859 0.59126669933662 0.414252063165922 0.616833473868723 PITA;miRanda;mirMAP -0.622498782062005 4.5648477200687e-19 NA NA NA hsa-miR-7-1-3p PDGFC -0.462485777435991 0.665899751398166 0.414252063165922 0.616833473868723 mirMAP -0.683487588802839 1.48003343394682e-16 NA NA NA hsa-miR-7-5p PDGFC 0.209645143210379 0.773705612298441 0.414252063165922 0.616833473868723 miRNAWalker2_validate -0.355404199624497 6.53479001104984e-11 NA NA NA hsa-miR-125a-3p PDGFD 0.14689780893708 0.724764670752407 0.373704891557837 0.506977322141266 miRanda -0.301240683905164 3.81965160075026e-06 NA NA NA hsa-miR-19b-1-5p PDGFD -0.0105982583216702 0.988511655226679 0.373704891557837 0.506977322141266 MirTarget -0.345717271489925 5.0328296726647e-06 NA NA NA hsa-miR-203a-3p PDGFD -0.265248086637561 0.931593594361942 0.373704891557837 0.506977322141266 MirTarget -0.189899712371588 0.00217128481212937 NA NA NA hsa-miR-320b PDGFD -0.23561798088153 0.859222532827992 0.373704891557837 0.506977322141266 miRanda -0.281894373378923 0.00152966341011458 NA NA NA hsa-miR-331-5p PDGFD -0.450673082073933 0.250361590873666 0.373704891557837 0.506977322141266 MirTarget -0.45954324857632 4.49931356687149e-07 NA NA NA hsa-miR-374b-5p PDGFD -0.285682091626878 0.83569830479965 0.373704891557837 0.506977322141266 MirTarget;mirMAP -0.319164107426016 0.00577840952856108 NA NA NA hsa-miR-590-3p PDGFD -0.279244755376859 0.59126669933662 0.373704891557837 0.506977322141266 miRanda;mirMAP;miRNATAP -0.385624849353768 1.19268414995478e-08 NA NA NA hsa-miR-590-5p PDGFD -0.547819833829572 0.472735645776647 0.373704891557837 0.506977322141266 miRanda -0.481631209595548 7.86360288880717e-12 NA NA NA hsa-miR-7-1-3p PDGFD -0.462485777435991 0.665899751398166 0.373704891557837 0.506977322141266 mirMAP -0.439118502606612 3.23826516590321e-08 NA NA NA hsa-let-7a-3p PDGFRA -0.215598045625677 0.85543299203799 -0.145858107393819 0.902950557320272 mirMAP -0.46804730928802 1.13954952980613e-05 NA NA NA hsa-let-7f-1-3p PDGFRA -0.31101436822914 0.693407210545374 -0.145858107393819 0.902950557320272 mirMAP -0.516833762443087 0.000428514669277019 NA NA NA hsa-let-7g-3p PDGFRA -0.489638373791485 0.62941522205833 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.448281873669985 3.34960551496113e-08 NA NA NA hsa-miR-106a-5p PDGFRA -0.203919267842652 0.802213958426804 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.461331612749808 1.21459582544494e-06 NA NA NA hsa-miR-106b-5p PDGFRA -0.297128724729339 0.869294443540749 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.788405389096865 1.19973361815904e-13 NA NA NA hsa-miR-130b-3p PDGFRA -0.221667315324818 0.824660172394714 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.713055953049172 6.98352333830201e-14 NA NA NA hsa-miR-140-5p PDGFRA -0.229213026275906 0.847330111738616 -0.145858107393819 0.902950557320272 miRNAWalker2_validate;miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.378645948787408 0.00817849787504184 26297547 miR 140 5p inhibits ovarian cancer growth partially by repression of PDGFRA; Additionally PDGFRA was predicted the target gene of miR-140-5p; PDGFRA was inversely correlated with the expression of miR-140-5p in ovarian cancer cells ovarian cancer hsa-miR-141-3p PDGFRA -0.31994058840327 0.87774106909065 -0.145858107393819 0.902950557320272 MirTarget -0.558254342811311 1.59735147532957e-12 NA NA NA hsa-miR-16-1-3p PDGFRA 0.151694812889216 0.733736501874638 -0.145858107393819 0.902950557320272 MirTarget -0.391474995802884 3.72447068651333e-06 NA NA NA hsa-miR-17-5p PDGFRA -0.175448849583061 0.934544015912731 -0.145858107393819 0.902950557320272 MirTarget;TargetScan;miRNATAP -0.500899724208041 1.35275307087739e-09 NA NA NA hsa-miR-182-5p PDGFRA -0.104238497940557 0.973380614062243 -0.145858107393819 0.902950557320272 miRNATAP -0.351343598684222 3.64495302642716e-05 NA NA NA hsa-miR-186-5p PDGFRA -0.318786974828757 0.85412722938961 -0.145858107393819 0.902950557320272 MirTarget -0.680532199603127 4.02581457439773e-07 NA NA NA hsa-miR-193a-3p PDGFRA -0.247265785363732 0.654363581941634 -0.145858107393819 0.902950557320272 miRanda -0.308129712347872 0.000729810331533374 NA NA NA hsa-miR-196a-5p PDGFRA -0.0569856738232488 0.973093117800687 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.226717073924458 7.8971760883461e-05 NA NA NA hsa-miR-200a-3p PDGFRA -0.367034437440907 0.851059894150266 -0.145858107393819 0.902950557320272 MirTarget -0.414102446036165 1.51743336403368e-07 NA NA NA hsa-miR-20a-5p PDGFRA -0.179153323927949 0.928118119139752 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.403163295382866 1.05772983131811e-06 NA NA NA hsa-miR-2110 PDGFRA -0.317803483266315 0.250981343062022 -0.145858107393819 0.902950557320272 MirTarget -0.366181032284536 9.44460298164708e-05 NA NA NA hsa-miR-26b-5p PDGFRA -0.0245931278499594 0.990377966314923 -0.145858107393819 0.902950557320272 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.76554214258799 1.34342011356511e-09 NA NA NA hsa-miR-27a-3p PDGFRA -0.123902317731458 0.958804393510999 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.516042216303154 0.000914778337518972 NA NA NA hsa-miR-29a-3p PDGFRA 0.01127474410284 0.996977020481272 -0.145858107393819 0.902950557320272 MirTarget -0.809568799779591 4.96242330696496e-11 NA NA NA hsa-miR-29b-1-5p PDGFRA -0.642348119412534 0.293891497238796 -0.145858107393819 0.902950557320272 mirMAP -0.425193514964668 2.19115837746288e-10 NA NA NA hsa-miR-29b-3p PDGFRA -0.104016192263954 0.958988036765397 -0.145858107393819 0.902950557320272 MirTarget -0.70477380352231 1.49237333469501e-14 NA NA NA hsa-miR-301a-3p PDGFRA -0.105312511901769 0.831686745977347 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.397818747734378 1.84518884433226e-06 NA NA NA hsa-miR-320b PDGFRA -0.23561798088153 0.859222532827992 -0.145858107393819 0.902950557320272 miRanda -0.271817768499418 0.00931638762599068 NA NA NA hsa-miR-335-3p PDGFRA -0.244830745789445 0.88450019116631 -0.145858107393819 0.902950557320272 mirMAP -0.35160587390058 6.70186373595121e-05 NA NA NA hsa-miR-339-5p PDGFRA -0.300425087100667 0.712912847076788 -0.145858107393819 0.902950557320272 miRanda -0.457485269989944 3.66341806935034e-09 NA NA NA hsa-miR-33a-5p PDGFRA -0.205788753603336 0.853314500865147 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.272405442549699 1.25878366881518e-07 NA NA NA hsa-miR-33b-5p PDGFRA -0.161971614375297 0.737436207821109 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.351193123166394 4.89573526569498e-10 NA NA NA hsa-miR-34a-5p PDGFRA -0.50188164870224 0.742034237185732 -0.145858107393819 0.902950557320272 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.293946617803388 0.00483203526840856 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-362-3p PDGFRA -0.721040238345347 0.0345881362485733 -0.145858107393819 0.902950557320272 miRanda -0.331137641396915 2.44365531587286e-05 NA NA NA hsa-miR-374b-5p PDGFRA -0.285682091626878 0.83569830479965 -0.145858107393819 0.902950557320272 mirMAP -0.489332532273884 0.000275322473260306 NA NA NA hsa-miR-421 PDGFRA -0.182032017078616 0.734704500318599 -0.145858107393819 0.902950557320272 PITA;miRanda;miRNATAP -0.331972101032041 0.000352331324069819 NA NA NA hsa-miR-429 PDGFRA -0.456485631615963 0.806240953400535 -0.145858107393819 0.902950557320272 miRanda;miRNATAP -0.427308243384876 1.22907424761067e-08 NA NA NA hsa-miR-454-3p PDGFRA -0.101514866328011 0.843545158256191 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.526182378920795 4.63430277666318e-06 NA NA NA hsa-miR-550a-5p PDGFRA -0.390865630073894 0.535659273352227 -0.145858107393819 0.902950557320272 MirTarget -0.303957080101116 0.000421501403265132 NA NA NA hsa-miR-576-5p PDGFRA -0.506413219377403 0.417187951364173 -0.145858107393819 0.902950557320272 mirMAP -0.53161391653101 2.34508916321778e-08 NA NA NA hsa-miR-589-3p PDGFRA -0.835836305204965 0.0112001563801511 -0.145858107393819 0.902950557320272 mirMAP -0.324416945059502 1.4854980540892e-05 NA NA NA hsa-miR-590-3p PDGFRA -0.279244755376859 0.59126669933662 -0.145858107393819 0.902950557320272 miRanda;mirMAP -0.505584545520693 1.12850394310824e-10 NA NA NA hsa-miR-590-5p PDGFRA -0.547819833829572 0.472735645776647 -0.145858107393819 0.902950557320272 miRanda -0.618116353853085 3.24347610137224e-14 NA NA NA hsa-miR-642a-5p PDGFRA 0.00605485088835034 0.98806034007652 -0.145858107393819 0.902950557320272 MirTarget -0.215832054890106 0.000746473138697964 NA NA NA hsa-miR-7-1-3p PDGFRA -0.462485777435991 0.665899751398166 -0.145858107393819 0.902950557320272 mirMAP -0.523812035758304 1.699078163408e-08 NA NA NA hsa-miR-93-5p PDGFRA -0.611073677204699 0.825297877093193 -0.145858107393819 0.902950557320272 MirTarget;miRNATAP -0.562179024434523 5.29517125454282e-08 NA NA NA hsa-miR-96-5p PDGFRA 0.0854810872029343 0.923087820185031 -0.145858107393819 0.902950557320272 TargetScan;miRNATAP -0.531895407762512 3.58063096797815e-11 NA NA NA hsa-miR-224-5p PDGFRB -0.240425158977724 0.857351098476517 0.269735385981489 0.859643412257275 miRNAWalker2_validate -0.167596299133301 0.00451959282563429 NA NA NA hsa-miR-24-3p PDGFRB -0.0484778924256624 0.985274054814493 0.269735385981489 0.859643412257275 MirTarget -0.497348994016324 0.00212455415626555 NA NA NA hsa-miR-29a-3p PDGFRB 0.01127474410284 0.996977020481272 0.269735385981489 0.859643412257275 miRNATAP -0.749182849370106 8.28046458679609e-14 NA NA NA hsa-miR-29b-3p PDGFRB -0.104016192263954 0.958988036765397 0.269735385981489 0.859643412257275 miRNATAP -0.585510495081087 9.96403642896333e-15 NA NA NA hsa-miR-421 PDGFRB -0.182032017078616 0.734704500318599 0.269735385981489 0.859643412257275 miRanda -0.362666739511917 1.74841862274672e-06 NA NA NA hsa-miR-484 PDGFRB -0.179977202691249 0.886333755572375 0.269735385981489 0.859643412257275 mirMAP -0.538053678604706 4.36179283359931e-08 NA NA NA hsa-miR-22-5p PDPK1 -0.0785922550675187 0.93169760098231 -0.00199665299108798 0.998927104341219 miRNATAP -0.11021672261126 0.00107500585415004 NA NA NA hsa-miR-429 PGF -0.456485631615963 0.806240953400535 0.246821616713936 0.742062581671624 miRNATAP -0.157730468642131 0.00280494441192971 NA NA NA hsa-let-7f-2-3p PIK3AP1 -0.0455032713433074 0.882115725419367 -0.312761671336713 0.778595688722594 MirTarget -0.197646416391677 0.00524920362167149 NA NA NA hsa-miR-106b-5p PIK3AP1 -0.297128724729339 0.869294443540749 -0.312761671336713 0.778595688722594 miRNAWalker2_validate -0.280549092172088 0.00291892649752682 NA NA NA hsa-miR-1275 PIK3AP1 -0.831342050607648 0.0803795852164229 -0.312761671336713 0.778595688722594 MirTarget -0.226605621138803 9.06842688307649e-06 NA NA NA hsa-miR-29a-5p PIK3AP1 -0.31835175571979 0.600442757817281 -0.312761671336713 0.778595688722594 mirMAP -0.228985703859489 0.0022370610473049 NA NA NA hsa-miR-374a-5p PIK3AP1 -0.343007247142618 0.766921280269271 -0.312761671336713 0.778595688722594 mirMAP -0.39357760475163 0.000778730263086164 NA NA NA hsa-miR-374b-5p PIK3AP1 -0.285682091626878 0.83569830479965 -0.312761671336713 0.778595688722594 mirMAP -0.435066907575843 0.000119745513276458 NA NA NA hsa-miR-421 PIK3AP1 -0.182032017078616 0.734704500318599 -0.312761671336713 0.778595688722594 miRanda -0.339334982230573 1.25456717459154e-05 NA NA NA hsa-miR-92a-3p PIK3AP1 0.0278830870766349 0.993247426671713 -0.312761671336713 0.778595688722594 MirTarget -0.375203127660061 6.80942589534186e-06 NA NA NA hsa-miR-940 PIK3AP1 -0.225788347550697 0.680055767105815 -0.312761671336713 0.778595688722594 MirTarget -0.182829194353304 0.00182868967719601 NA NA NA hsa-let-7f-1-3p PIK3CA -0.31101436822914 0.693407210545374 0.0225357621933919 0.979422693316883 mirMAP -0.118501081655342 0.0064771514178073 NA NA NA hsa-miR-148a-5p PIK3CA -0.448099743845604 0.748419139652266 0.0225357621933919 0.979422693316883 mirMAP -0.112357517651492 7.06215647986463e-05 NA NA NA hsa-miR-148b-3p PIK3CA -0.202106692287125 0.911884960581838 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.117892096365902 0.00490902202717801 NA NA NA hsa-miR-16-2-3p PIK3CA -0.36717860153421 0.546850726070016 0.0225357621933919 0.979422693316883 mirMAP -0.10245614796563 9.13897985797286e-05 NA NA NA hsa-miR-17-5p PIK3CA -0.175448849583061 0.934544015912731 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.115705723770344 3.03228335548689e-06 NA NA NA hsa-miR-186-5p PIK3CA -0.318786974828757 0.85412722938961 0.0225357621933919 0.979422693316883 mirMAP -0.146329134056921 0.000268937701971312 NA NA NA hsa-miR-32-3p PIK3CA -0.568003960723004 0.13133163420273 0.0225357621933919 0.979422693316883 mirMAP -0.112972746252127 2.51225612643757e-08 NA NA NA hsa-miR-335-5p PIK3CA -0.0284895175847679 0.973380867832231 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.10180509768488 9.82755134026126e-05 NA NA NA hsa-miR-339-5p PIK3CA -0.300425087100667 0.712912847076788 0.0225357621933919 0.979422693316883 miRanda -0.103587269763801 8.44655068921029e-06 NA NA NA hsa-miR-374b-5p PIK3CA -0.285682091626878 0.83569830479965 0.0225357621933919 0.979422693316883 mirMAP -0.142766383581644 0.00032150800529493 NA NA NA hsa-miR-501-5p PIK3CA -0.834032628506285 0.0582725160418523 0.0225357621933919 0.979422693316883 mirMAP -0.110757579310586 1.16330645525834e-07 NA NA NA hsa-miR-576-5p PIK3CA -0.506413219377403 0.417187951364173 0.0225357621933919 0.979422693316883 PITA -0.113974010997229 6.59094941020168e-05 NA NA NA hsa-miR-582-3p PIK3CA -0.2334649592375 0.897678119160318 0.0225357621933919 0.979422693316883 miRNATAP -0.140113361530972 2.23178585157338e-06 NA NA NA hsa-miR-590-3p PIK3CA -0.279244755376859 0.59126669933662 0.0225357621933919 0.979422693316883 miRanda;mirMAP -0.123897140594567 1.31301452772078e-07 NA NA NA hsa-miR-590-5p PIK3CA -0.547819833829572 0.472735645776647 0.0225357621933919 0.979422693316883 miRanda -0.140125048782077 1.41706046141534e-08 NA NA NA hsa-miR-96-5p PIK3CA 0.0854810872029343 0.923087820185031 0.0225357621933919 0.979422693316883 TargetScan -0.128475980855667 9.81905908048452e-08 NA NA NA hsa-miR-1468-5p PIK3CD -0.200868572236891 0.688408103178562 -0.0499659666229988 0.947033498136668 MirTarget -0.293090508926218 0.000248785469894942 NA NA NA hsa-miR-29a-3p PIK3CD 0.01127474410284 0.996977020481272 -0.0499659666229988 0.947033498136668 mirMAP -0.351166771873915 0.00243536234086878 NA NA NA hsa-miR-29b-3p PIK3CD -0.104016192263954 0.958988036765397 -0.0499659666229988 0.947033498136668 mirMAP -0.263613715224296 0.00266331795083224 NA NA NA hsa-miR-30b-5p PIK3CD -0.0121430518253582 0.994622896704513 -0.0499659666229988 0.947033498136668 MirTarget -0.395682674717868 3.65190942130723e-06 NA NA NA hsa-miR-30c-5p PIK3CD -0.298383882401475 0.865809030482001 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.419452305097446 0.000712699686404817 NA NA NA hsa-miR-30d-5p PIK3CD -0.168211838771867 0.95173197030375 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.360885227262785 0.00123008895505406 NA NA NA hsa-miR-421 PIK3CD -0.182032017078616 0.734704500318599 -0.0499659666229988 0.947033498136668 miRanda -0.48895286723391 2.44692621373687e-09 NA NA NA hsa-miR-484 PIK3CD -0.179977202691249 0.886333755572375 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.351057480112147 0.00143452196121959 NA NA NA hsa-miR-7-5p PIK3CD 0.209645143210379 0.773705612298441 -0.0499659666229988 0.947033498136668 miRTarBase;MirTarget;miRNATAP -0.196228010352377 0.000352590199023202 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-942-5p PIK3CD -0.50502396741886 0.50777904281306 -0.0499659666229988 0.947033498136668 MirTarget -0.192312219113083 0.0086308226579878 NA NA NA hsa-miR-126-3p PIK3CG -0.106293136341574 0.963670566555251 -0.358088978987777 0.469718116584845 miRTarBase -0.534372493039168 0.000484031176443627 NA NA NA hsa-miR-26b-5p PIK3CG -0.0245931278499594 0.990377966314923 -0.358088978987777 0.469718116584845 miRNAWalker2_validate -0.795245028298382 7.45064172731532e-07 NA NA NA hsa-miR-29b-3p PIK3CG -0.104016192263954 0.958988036765397 -0.358088978987777 0.469718116584845 miRTarBase -0.666133284835925 1.9528746633095e-08 NA NA NA hsa-miR-335-3p PIK3CG -0.244830745789445 0.88450019116631 -0.358088978987777 0.469718116584845 mirMAP -0.563949149516835 2.51672261116185e-07 NA NA NA hsa-miR-421 PIK3CG -0.182032017078616 0.734704500318599 -0.358088978987777 0.469718116584845 miRanda -0.444524915857051 0.000133233454665448 NA NA NA hsa-miR-502-5p PIK3CG -0.708507838520586 0.0261309781860104 -0.358088978987777 0.469718116584845 miRNATAP -0.340480467784473 0.000652722824953133 26163264 Phosphoinositide 3-kinase catalytic subunit gamma PIK3CG was identified as a direct downstream target of miR-502 in HCC cells; Notably overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells liver cancer hsa-miR-590-3p PIK3CG -0.279244755376859 0.59126669933662 -0.358088978987777 0.469718116584845 miRanda -0.438492197588501 1.39596666922937e-05 NA NA NA hsa-miR-132-3p PIK3R1 -0.244143673573889 0.871752726220643 -0.107670470040419 0.937523599303491 MirTarget -0.191363026291576 0.00729852053203983 NA NA NA hsa-miR-15a-5p PIK3R1 -0.0674049094129128 0.964835434214123 -0.107670470040419 0.937523599303491 MirTarget -0.217108462406312 8.91731617861317e-05 NA NA NA hsa-miR-15b-5p PIK3R1 -0.272614787130877 0.87096541832188 -0.107670470040419 0.937523599303491 MirTarget -0.14300320532504 0.00643583854060318 NA NA NA hsa-miR-16-5p PIK3R1 0.0135949734723564 0.994476223855607 -0.107670470040419 0.937523599303491 MirTarget -0.189731088951203 0.0002621971143127 NA NA NA hsa-miR-185-5p PIK3R1 -0.294432218239008 0.820591478398594 -0.107670470040419 0.937523599303491 miRNATAP -0.23627908813405 0.00027005032337405 NA NA NA hsa-miR-21-5p PIK3R1 -0.148920887107433 0.970240620972126 -0.107670470040419 0.937523599303491 miRNAWalker2_validate;MirTarget;miRNATAP -0.32048586087571 3.69693869528844e-05 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.0224067199236484 0.973232008101458 -0.107670470040419 0.937523599303491 MirTarget -0.229364822725893 5.39528810633945e-05 NA NA NA hsa-miR-22-5p PIK3R1 -0.0785922550675187 0.93169760098231 -0.107670470040419 0.937523599303491 mirMAP -0.186145388676108 2.66965799007355e-05 NA NA NA hsa-miR-221-3p PIK3R1 0.0906940388127513 0.959121118272534 -0.107670470040419 0.937523599303491 MirTarget -0.197435928682178 0.000527618156345501 NA NA NA hsa-miR-222-3p PIK3R1 -0.0265849318772702 0.984005474689108 -0.107670470040419 0.937523599303491 MirTarget -0.202803725155249 6.41878654683067e-05 NA NA NA hsa-miR-369-3p PIK3R1 0.116576891957687 0.83230082995912 -0.107670470040419 0.937523599303491 PITA -0.167895129809982 0.000380018195201003 NA NA NA hsa-miR-424-5p PIK3R1 0.247080963500746 0.870154571783568 -0.107670470040419 0.937523599303491 MirTarget -0.119382000204097 0.00203768025896863 NA NA NA hsa-miR-450b-5p PIK3R1 -0.0136687538973108 0.983149761399849 -0.107670470040419 0.937523599303491 miRNATAP -0.190787246019265 6.82791616588e-05 NA NA NA hsa-miR-542-3p PIK3R1 0.188168046511374 0.909252939431573 -0.107670470040419 0.937523599303491 MirTarget;PITA;miRanda -0.150969723974234 0.00748950466389255 NA NA NA hsa-miR-582-5p PIK3R1 -0.399450205475138 0.581227478860085 -0.107670470040419 0.937523599303491 mirMAP -0.142451077115944 0.0045721005781701 NA NA NA hsa-miR-590-3p PIK3R1 -0.279244755376859 0.59126669933662 -0.107670470040419 0.937523599303491 miRanda;mirMAP -0.146401290926594 0.000138874186663878 NA NA NA hsa-miR-590-5p PIK3R1 -0.547819833829572 0.472735645776647 -0.107670470040419 0.937523599303491 MirTarget;PITA;miRanda;miRNATAP -0.15721405103923 0.000108223764424085 NA NA NA hsa-miR-30a-5p PIK3R2 0.219472325612346 0.933954023293816 -0.297680606771329 0.850152230341952 miRNATAP -0.205862820761505 5.83465711487357e-06 NA NA NA hsa-miR-181c-5p PIK3R3 0.042951891660695 0.969159991881861 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.166375015135553 0.00307339705460455 NA NA NA hsa-miR-181d-5p PIK3R3 0.14926527647499 0.888000971478017 -0.276772749610974 0.793454902449853 MirTarget -0.160008098502222 0.000261018045617695 NA NA NA hsa-miR-19a-3p PIK3R3 -0.206793507801887 0.844637784802316 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.116147528359031 0.00952170048888319 NA NA NA hsa-miR-19b-3p PIK3R3 -0.0268530183621474 0.986656783046572 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.194729521448902 0.000250390771046988 NA NA NA hsa-miR-32-5p PIK3R3 -0.05993267619119 0.952975951594959 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.138065839958076 0.00869251602983598 NA NA NA hsa-miR-335-3p PIK3R3 -0.244830745789445 0.88450019116631 -0.276772749610974 0.793454902449853 mirMAP -0.200911178812086 3.4951167686824e-05 NA NA NA hsa-miR-339-5p PIK3R3 -0.300425087100667 0.712912847076788 -0.276772749610974 0.793454902449853 MirTarget;miRanda -0.114440753951127 0.00949514702310638 NA NA NA hsa-miR-454-3p PIK3R3 -0.101514866328011 0.843545158256191 -0.276772749610974 0.793454902449853 mirMAP -0.183582040707033 0.00426750044797469 NA NA NA hsa-miR-92a-3p PIK3R3 0.0278830870766349 0.993247426671713 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.264671393069774 1.12229021521678e-06 NA NA NA hsa-miR-182-5p PIK3R5 -0.104238497940557 0.973380614062243 -0.266913830275555 0.638823741545427 MirTarget -0.335738588315792 0.000137422868989864 NA NA NA hsa-miR-18a-3p PIK3R5 -0.270443061178857 0.535291623032886 -0.266913830275555 0.638823741545427 MirTarget -0.247792416366587 0.000674544930154222 NA NA NA hsa-miR-194-3p PIK3R6 -0.614465699221301 0.733214497063146 0.251044378972685 0.477545675191093 MirTarget -0.415084690893287 1.4548193662006e-08 NA NA NA hsa-miR-30c-1-3p PIK3R6 -0.202466672579761 0.511485842123022 0.251044378972685 0.477545675191093 MirTarget -0.369003047666068 1.70241081416621e-06 NA NA NA hsa-miR-939-5p PIK3R6 -0.311196961912953 0.304447903545905 0.251044378972685 0.477545675191093 MirTarget -0.309643353614919 9.84325419312431e-05 NA NA NA hsa-let-7e-5p PKN2 0.211156073215582 0.922335699862928 -0.321550735714936 0.81208067440962 miRNATAP -0.131637215048464 0.00428384749241685 NA NA NA hsa-miR-127-3p PKN2 0.0756694410683956 0.972625730635758 -0.321550735714936 0.81208067440962 MirTarget;miRanda -0.112641224821791 0.00285042813341658 NA NA NA hsa-miR-143-3p PKN2 0.371591944134735 0.927341352649583 -0.321550735714936 0.81208067440962 MirTarget -0.104329181163214 0.00260526776854106 NA NA NA hsa-miR-199a-5p PKN2 0.157247797504494 0.935797462797012 -0.321550735714936 0.81208067440962 miRNATAP -0.118163107010666 0.000493602094676074 NA NA NA hsa-miR-218-5p PKN2 0.233108057313884 0.810208076649842 -0.321550735714936 0.81208067440962 MirTarget -0.132951894924257 2.1350986134221e-06 NA NA NA hsa-miR-1275 PKN3 -0.831342050607648 0.0803795852164229 0.191781949958727 0.822075629554107 MirTarget -0.162752155100642 2.17623493154638e-06 NA NA NA hsa-miR-143-5p PPP2CA 0.10589969923845 0.933358732923556 0.0356851568486913 0.982479603446852 MirTarget -0.113970843387226 3.04336029101809e-06 NA NA NA hsa-miR-30a-5p PPP2CA 0.219472325612346 0.933954023293816 0.0356851568486913 0.982479603446852 mirMAP -0.120297904871551 0.00285198820090026 NA NA NA hsa-miR-101-3p PPP2R2A 0.0107754887734437 0.997036362636866 -0.376525611168588 0.774872061631308 miRNATAP -0.247478465945909 0.000327833824337307 NA NA NA hsa-miR-199a-3p PPP2R2A 0.0782166873040424 0.973766909565326 -0.376525611168588 0.774872061631308 MirTarget;PITA;miRNATAP -0.15806723526116 0.00441008332805935 NA NA NA hsa-miR-199b-3p PPP2R2A 0.0780653337513897 0.973815251150337 -0.376525611168588 0.774872061631308 MirTarget;PITA;miRNATAP -0.158025899752298 0.00442035878651086 NA NA NA hsa-miR-218-5p PPP2R2A 0.233108057313884 0.810208076649842 -0.376525611168588 0.774872061631308 MirTarget;miRNATAP -0.199095945321522 2.54425439749271e-06 NA NA NA hsa-miR-30a-5p PPP2R2A 0.219472325612346 0.933954023293816 -0.376525611168588 0.774872061631308 miRNAWalker2_validate -0.306219230383086 1.13520790952282e-05 NA NA NA hsa-miR-107 PPP2R2B -0.0365118169251648 0.988364120226869 0.48175285133409 0.37897262455103 miRanda -0.882121899062359 1.43582656319098e-06 NA NA NA hsa-miR-10a-3p PPP2R2B -0.0996469316906681 0.882902638592481 0.48175285133409 0.37897262455103 mirMAP -0.494479845981588 8.6744588461004e-09 NA NA NA hsa-miR-126-5p PPP2R2B 0.0815213541035824 0.956637332055185 0.48175285133409 0.37897262455103 MirTarget -0.388681959529858 0.00628697449291432 NA NA NA hsa-miR-141-3p PPP2R2B -0.31994058840327 0.87774106909065 0.48175285133409 0.37897262455103 TargetScan -0.865846686159716 9.7342080343568e-25 NA NA NA hsa-miR-30e-3p PPP2R2B -0.220498559176349 0.938660731870214 0.48175285133409 0.37897262455103 miRNAWalker2_validate -0.913213187104777 5.10426300284459e-06 NA NA NA hsa-miR-361-5p PPP2R2B -0.138735309928775 0.941495130308343 0.48175285133409 0.37897262455103 miRanda -1.09857495867709 1.35994862616829e-09 NA NA NA hsa-miR-486-5p PPP2R2B -0.547739229538641 0.696404149927963 0.48175285133409 0.37897262455103 miRanda -0.231594990506113 0.00178770066287725 NA NA NA hsa-miR-7-1-3p PPP2R2B -0.462485777435991 0.665899751398166 0.48175285133409 0.37897262455103 mirMAP -0.739779925226521 6.61705711547172e-13 NA NA NA hsa-miR-939-5p PPP2R2B -0.311196961912953 0.304447903545905 0.48175285133409 0.37897262455103 MirTarget -0.62595294865228 1.85978367305245e-11 NA NA NA hsa-miR-625-5p PPP2R2C -0.690759472145277 0.210306534567564 1.5608588105306 0.0250320787195977 MirTarget -0.370350061915735 0.00602063143019348 NA NA NA hsa-miR-106a-5p PPP2R3A -0.203919267842652 0.802213958426804 -0.0608485254124691 0.927882334992608 mirMAP -0.265721889929827 1.41364540802916e-05 NA NA NA hsa-miR-106b-5p PPP2R3A -0.297128724729339 0.869294443540749 -0.0608485254124691 0.927882334992608 mirMAP -0.29877539369307 2.55050583413908e-05 NA NA NA hsa-miR-128-3p PPP2R3A -0.442192625156042 0.783886533572187 -0.0608485254124691 0.927882334992608 MirTarget -0.355349397611267 7.68383560135924e-06 NA NA NA hsa-miR-1304-5p PPP2R3A -0.497887681787993 0.163079003594721 -0.0608485254124691 0.927882334992608 MirTarget -0.231587320826006 2.80963349497649e-07 NA NA NA hsa-miR-148b-3p PPP2R3A -0.202106692287125 0.911884960581838 -0.0608485254124691 0.927882334992608 miRNAWalker2_validate -0.34179601503823 0.000155077410757064 NA NA NA hsa-miR-17-5p PPP2R3A -0.175448849583061 0.934544015912731 -0.0608485254124691 0.927882334992608 mirMAP -0.25544002466112 2.03182659318753e-06 NA NA NA hsa-miR-181b-5p PPP2R3A 0.155313039554487 0.930176779696506 -0.0608485254124691 0.927882334992608 MirTarget -0.223697884813998 0.00236299682222327 NA NA NA hsa-miR-186-5p PPP2R3A -0.318786974828757 0.85412722938961 -0.0608485254124691 0.927882334992608 MirTarget;mirMAP -0.279684312162077 0.00139492534649192 NA NA NA hsa-miR-20a-5p PPP2R3A -0.179153323927949 0.928118119139752 -0.0608485254124691 0.927882334992608 mirMAP -0.224514831309879 2.49849765708693e-05 NA NA NA hsa-miR-26a-2-3p PPP2R3A -0.427772454814258 0.28776911697575 -0.0608485254124691 0.927882334992608 mirMAP -0.16757961975701 0.00294852828127891 NA NA NA hsa-miR-26b-5p PPP2R3A -0.0245931278499594 0.990377966314923 -0.0608485254124691 0.927882334992608 miRNATAP -0.221994391770086 0.00794064942371029 NA NA NA hsa-miR-429 PPP2R3A -0.456485631615963 0.806240953400535 -0.0608485254124691 0.927882334992608 miRanda -0.144730943807048 0.00336419322107732 NA NA NA hsa-miR-502-5p PPP2R3A -0.708507838520586 0.0261309781860104 -0.0608485254124691 0.927882334992608 miRNATAP -0.176001564468532 0.00055182597660085 NA NA NA hsa-miR-576-5p PPP2R3A -0.506413219377403 0.417187951364173 -0.0608485254124691 0.927882334992608 PITA;mirMAP -0.211227506556358 0.000702652101421923 NA NA NA hsa-miR-577 PPP2R3A -1.06238199218774 0.326056761787754 -0.0608485254124691 0.927882334992608 MirTarget -0.13453176071046 2.81801107133807e-05 NA NA NA hsa-miR-589-5p PPP2R3A -0.448771545046784 0.722725226273464 -0.0608485254124691 0.927882334992608 MirTarget -0.322918341224638 0.00015226432501685 NA NA NA hsa-miR-590-3p PPP2R3A -0.279244755376859 0.59126669933662 -0.0608485254124691 0.927882334992608 MirTarget;PITA;miRanda -0.265787304113019 1.90164805847033e-07 NA NA NA hsa-miR-93-5p PPP2R3A -0.611073677204699 0.825297877093193 -0.0608485254124691 0.927882334992608 mirMAP -0.230967257741471 0.000624508486982437 NA NA NA hsa-miR-361-5p PPP2R3C -0.138735309928775 0.941495130308343 0.088892941838763 0.92663780521344 miRanda -0.1384748157348 0.00275797639682729 NA NA NA hsa-miR-125a-5p PPP2R5C -0.00183986061615382 0.999158100170883 -0.0416764418339968 0.979060666938948 MirTarget;PITA;miRanda -0.128116734610181 0.000513753699682629 NA NA NA hsa-miR-132-3p PPP2R5C -0.244143673573889 0.871752726220643 -0.0416764418339968 0.979060666938948 miRNATAP -0.125263910265897 0.00408623818705044 NA NA NA hsa-miR-125a-5p PPP2R5E -0.00183986061615382 0.999158100170883 -0.315676038449801 0.782415509075426 miRNAWalker2_validate -0.206654538213536 2.85766790777101e-07 NA NA NA hsa-miR-130a-3p PPP2R5E 0.0910074087716906 0.929098200371948 -0.315676038449801 0.782415509075426 mirMAP -0.162786000810969 3.40039221813072e-07 NA NA NA hsa-miR-181a-5p PPP2R5E 0.0295101956318291 0.989325168350125 -0.315676038449801 0.782415509075426 MirTarget;mirMAP -0.127362411490184 0.000820389638518227 NA NA NA hsa-miR-181b-5p PPP2R5E 0.155313039554487 0.930176779696506 -0.315676038449801 0.782415509075426 MirTarget;mirMAP -0.119994528183826 0.00120115585852406 NA NA NA hsa-miR-199a-3p PPP2R5E 0.0782166873040424 0.973766909565326 -0.315676038449801 0.782415509075426 MirTarget;PITA -0.142900049123088 0.000138668354582098 NA NA NA hsa-miR-199b-3p PPP2R5E 0.0780653337513897 0.973815251150337 -0.315676038449801 0.782415509075426 MirTarget;PITA;miRNATAP -0.142871028193333 0.000139104402673137 NA NA NA hsa-miR-224-3p PPP2R5E 0.110372723153393 0.749091467231007 -0.315676038449801 0.782415509075426 mirMAP -0.106273069320977 1.89725476200205e-05 NA NA NA hsa-miR-23a-3p PPP2R5E -0.122198715333656 0.962717452143511 -0.315676038449801 0.782415509075426 MirTarget -0.278139919171475 1.27767565860005e-06 24997345 Downregulation of PPP2R5E expression by miR 23a suppresses apoptosis to facilitate the growth of gastric cancer cells; Here we declare that PPP2R5E is downregulated by miR-23a and induces cell growth inhibition and apoptosis in gastric cancer cells; PPP2R5E is identified as a new target of miR-23a; Moreover overexpression of PPP2R5E reversed the negative effects of miR-23a; We highlight the significance of miR-23a and PPP2R5E in the proliferation and apoptosis of gastric cancer cells gastric cancer hsa-miR-323a-3p PPP2R5E 0.279126405514894 0.478782330851768 -0.315676038449801 0.782415509075426 mirMAP -0.107447923933299 6.00091439116037e-05 NA NA NA hsa-miR-361-5p PPP2R5E -0.138735309928775 0.941495130308343 -0.315676038449801 0.782415509075426 miRanda -0.204044613003842 0.000116825054008582 NA NA NA hsa-miR-365a-3p PPP2R5E 0.0797451871548276 0.938758494058574 -0.315676038449801 0.782415509075426 miRNAWalker2_validate -0.11656185008126 0.00310912775237505 NA NA NA hsa-miR-374b-5p PPP2R5E -0.285682091626878 0.83569830479965 -0.315676038449801 0.782415509075426 mirMAP -0.151025762980418 0.000517777925342188 NA NA NA hsa-miR-101-3p PRKAA1 0.0107754887734437 0.997036362636866 -0.165446802004539 0.911017838702257 MirTarget;miRNATAP -0.16917213844282 0.000159540976904725 NA NA NA hsa-miR-126-5p PRKAA1 0.0815213541035824 0.956637332055185 -0.165446802004539 0.911017838702257 mirMAP -0.182966892379109 1.6097058628994e-06 NA NA NA hsa-miR-130a-3p PRKAA1 0.0910074087716906 0.929098200371948 -0.165446802004539 0.911017838702257 MirTarget;miRNATAP -0.175002779933657 7.72068997440457e-09 NA NA NA hsa-miR-142-5p PRKAA1 -0.118920788314118 0.929665277963083 -0.165446802004539 0.911017838702257 PITA;mirMAP -0.101476180651905 0.000168308839474968 NA NA NA hsa-miR-146b-3p PRKAA1 -0.408862981477661 0.762520540478861 -0.165446802004539 0.911017838702257 MirTarget;PITA;miRNATAP -0.10166543186724 0.00175087926243424 NA NA NA hsa-miR-152-3p PRKAA1 0.203532896690202 0.90975730233375 -0.165446802004539 0.911017838702257 MirTarget -0.195684681215086 0.000166794973895574 NA NA NA hsa-miR-154-3p PRKAA1 -0.170366170038505 0.546500133020447 -0.165446802004539 0.911017838702257 MirTarget -0.137022353605923 1.74925797229127e-06 NA NA NA hsa-miR-30a-5p PRKAA1 0.219472325612346 0.933954023293816 -0.165446802004539 0.911017838702257 miRNAWalker2_validate -0.161862346655212 0.000407673853300811 NA NA NA hsa-miR-495-3p PRKAA1 0.00168200867117596 0.997533662527025 -0.165446802004539 0.911017838702257 mirMAP -0.134239921630036 0.000389251864412267 NA NA NA hsa-miR-497-5p PRKAA1 -0.0120217191428731 0.989147225742026 -0.165446802004539 0.911017838702257 MirTarget -0.129214261225063 0.000426095257692293 NA NA NA hsa-let-7a-5p PRKAA2 -0.0620211756550422 0.985006886285188 1.3524018076496 0.0611671965688077 MirTarget;TargetScan -1.3774349277681 4.40575800230604e-05 NA NA NA hsa-let-7b-3p PRKAA2 -0.286212135502696 0.812160509578046 1.3524018076496 0.0611671965688077 mirMAP -0.681359549278188 0.00864082451249208 NA NA NA hsa-let-7d-5p PRKAA2 -0.139747701175051 0.934164162708487 1.3524018076496 0.0611671965688077 MirTarget -1.0808124464292 0.000340967407233226 NA NA NA hsa-let-7f-1-3p PRKAA2 -0.31101436822914 0.693407210545374 1.3524018076496 0.0611671965688077 mirMAP -1.04475655583997 0.000198126659587119 NA NA NA hsa-let-7f-5p PRKAA2 0.048789917034723 0.987280455481631 1.3524018076496 0.0611671965688077 MirTarget -1.25748553533529 1.06108331603952e-05 NA NA NA hsa-let-7g-5p PRKAA2 -0.200947212961157 0.922992045181955 1.3524018076496 0.0611671965688077 MirTarget -1.48951694235668 2.21507457470249e-07 NA NA NA hsa-miR-106b-5p PRKAA2 -0.297128724729339 0.869294443540749 1.3524018076496 0.0611671965688077 mirMAP -0.749379041166482 0.00045170381035773 NA NA NA hsa-miR-10a-5p PRKAA2 0.0740585720685925 0.983770933356406 1.3524018076496 0.0611671965688077 MirTarget -0.485307367052801 0.0067774444725377 NA NA NA hsa-miR-130b-3p PRKAA2 -0.221667315324818 0.824660172394714 1.3524018076496 0.0611671965688077 MirTarget -0.588519017811155 0.00220222230221989 NA NA NA hsa-miR-141-3p PRKAA2 -0.31994058840327 0.87774106909065 1.3524018076496 0.0611671965688077 mirMAP -0.7237523018411 3.63348108517845e-06 NA NA NA hsa-miR-146a-5p PRKAA2 -0.581292803346906 0.73685134936757 1.3524018076496 0.0611671965688077 MirTarget -0.879161706521282 9.81298624966043e-09 NA NA NA hsa-miR-15b-3p PRKAA2 -0.557749208157585 0.609181305423188 1.3524018076496 0.0611671965688077 mirMAP -0.952477585223996 4.39269041503324e-07 NA NA NA hsa-miR-16-2-3p PRKAA2 -0.36717860153421 0.546850726070016 1.3524018076496 0.0611671965688077 mirMAP -0.849296279638287 4.44189322821268e-07 NA NA NA hsa-miR-17-5p PRKAA2 -0.175448849583061 0.934544015912731 1.3524018076496 0.0611671965688077 mirMAP -0.560187125590358 0.000582130294131559 NA NA NA hsa-miR-182-5p PRKAA2 -0.104238497940557 0.973380614062243 1.3524018076496 0.0611671965688077 miRNAWalker2_validate;MirTarget;mirMAP -0.662775728142482 4.86187881504762e-05 NA NA NA hsa-miR-186-5p PRKAA2 -0.318786974828757 0.85412722938961 1.3524018076496 0.0611671965688077 MirTarget -1.22340801207465 2.16812724466492e-06 NA NA NA hsa-miR-192-5p PRKAA2 -0.117345487848223 0.972927287653137 1.3524018076496 0.0611671965688077 miRNAWalker2_validate -0.733473079800383 4.27906815146448e-07 NA NA NA hsa-miR-19a-3p PRKAA2 -0.206793507801887 0.844637784802316 1.3524018076496 0.0611671965688077 mirMAP -0.46168551044351 0.00296159285257802 NA NA NA hsa-miR-200a-3p PRKAA2 -0.367034437440907 0.851059894150266 1.3524018076496 0.0611671965688077 mirMAP -0.482675549448898 0.00174597157504641 NA NA NA hsa-miR-200b-3p PRKAA2 -0.426401948379212 0.863957108574195 1.3524018076496 0.0611671965688077 MirTarget -0.798327128385879 9.24163890589522e-06 NA NA NA hsa-miR-200c-3p PRKAA2 -0.437282635857873 0.887118598436407 1.3524018076496 0.0611671965688077 MirTarget -0.869431098545426 2.52925399045918e-06 NA NA NA hsa-miR-203a-3p PRKAA2 -0.265248086637561 0.931593594361942 1.3524018076496 0.0611671965688077 MirTarget -0.527289239158294 0.000135284378990592 NA NA NA hsa-miR-20a-5p PRKAA2 -0.179153323927949 0.928118119139752 1.3524018076496 0.0611671965688077 mirMAP -0.529658710106026 0.000975267278142125 NA NA NA hsa-miR-21-3p PRKAA2 -0.395016549347053 0.87819982773565 1.3524018076496 0.0611671965688077 mirMAP -1.03899726703384 2.04856179048105e-06 NA NA NA hsa-miR-23a-3p PRKAA2 -0.122198715333656 0.962717452143511 1.3524018076496 0.0611671965688077 mirMAP -1.04156287853583 0.00263446744436447 NA NA NA hsa-miR-26a-1-3p PRKAA2 -0.429875601809349 0.182136384322617 1.3524018076496 0.0611671965688077 mirMAP -0.831931348543817 1.11599255200588e-07 NA NA NA hsa-miR-26a-2-3p PRKAA2 -0.427772454814258 0.28776911697575 1.3524018076496 0.0611671965688077 mirMAP -0.621925972203779 0.000208611065818212 NA NA NA hsa-miR-26b-5p PRKAA2 -0.0245931278499594 0.990377966314923 1.3524018076496 0.0611671965688077 mirMAP -0.877919448261694 0.000414963955029203 NA NA NA hsa-miR-30e-3p PRKAA2 -0.220498559176349 0.938660731870214 1.3524018076496 0.0611671965688077 MirTarget -1.53784464149708 5.63409730084565e-06 NA NA NA hsa-miR-30e-5p PRKAA2 -0.0657075181381011 0.979684509181941 1.3524018076496 0.0611671965688077 MirTarget -0.773980270542683 0.00794921376751559 NA NA NA hsa-miR-32-3p PRKAA2 -0.568003960723004 0.13133163420273 1.3524018076496 0.0611671965688077 MirTarget -0.481495573207177 0.000342223690957318 NA NA NA hsa-miR-331-3p PRKAA2 -0.40204226129616 0.670588911553669 1.3524018076496 0.0611671965688077 MirTarget -0.559581244175645 0.005382842440452 NA NA NA hsa-miR-335-3p PRKAA2 -0.244830745789445 0.88450019116631 1.3524018076496 0.0611671965688077 MirTarget -0.475040463884501 0.00535237454693503 NA NA NA hsa-miR-338-5p PRKAA2 0.484769112400393 0.393961930708873 1.3524018076496 0.0611671965688077 mirMAP -0.436365295570795 0.00124419268010689 NA NA NA hsa-miR-33a-3p PRKAA2 -0.794543849238581 0.0105203072007922 1.3524018076496 0.0611671965688077 mirMAP -0.78140196136191 4.75819311035266e-07 NA NA NA hsa-miR-340-5p PRKAA2 -0.00276909425328853 0.99757361161055 1.3524018076496 0.0611671965688077 MirTarget -0.803611072578256 0.000220849274859537 NA NA NA hsa-miR-34a-5p PRKAA2 -0.50188164870224 0.742034237185732 1.3524018076496 0.0611671965688077 miRNATAP -0.680721001282327 0.00062567886812767 NA NA NA hsa-miR-429 PRKAA2 -0.456485631615963 0.806240953400535 1.3524018076496 0.0611671965688077 MirTarget;miRNATAP -0.451648244320967 0.0022054440219677 NA NA NA hsa-miR-500a-5p PRKAA2 -0.71978560736831 0.188073776225276 1.3524018076496 0.0611671965688077 mirMAP -0.525095995468797 0.00097684748463756 NA NA NA hsa-miR-576-5p PRKAA2 -0.506413219377403 0.417187951364173 1.3524018076496 0.0611671965688077 mirMAP -0.958548116562417 1.67327435907317e-07 NA NA NA hsa-miR-577 PRKAA2 -1.06238199218774 0.326056761787754 1.3524018076496 0.0611671965688077 MirTarget;PITA;miRNATAP -0.409987394244555 1.96607711933672e-05 NA NA NA hsa-miR-582-5p PRKAA2 -0.399450205475138 0.581227478860085 1.3524018076496 0.0611671965688077 mirMAP -0.704031452597596 0.000475991710003507 NA NA NA hsa-miR-589-5p PRKAA2 -0.448771545046784 0.722725226273464 1.3524018076496 0.0611671965688077 MirTarget -1.28590342765677 3.25819586564613e-07 NA NA NA hsa-miR-590-3p PRKAA2 -0.279244755376859 0.59126669933662 1.3524018076496 0.0611671965688077 mirMAP;miRNATAP -0.666306737006168 1.53913852506846e-05 NA NA NA hsa-miR-7-1-3p PRKAA2 -0.462485777435991 0.665899751398166 1.3524018076496 0.0611671965688077 MirTarget;mirMAP -0.986105071845591 3.13495463371211e-08 NA NA NA hsa-miR-93-5p PRKAA2 -0.611073677204699 0.825297877093193 1.3524018076496 0.0611671965688077 mirMAP -0.860546653362638 1.76855487703335e-05 NA NA NA hsa-miR-96-5p PRKAA2 0.0854810872029343 0.923087820185031 1.3524018076496 0.0611671965688077 TargetScan -0.620424271055102 9.49537216168755e-05 NA NA NA hsa-miR-29a-5p PRKCA -0.31835175571979 0.600442757817281 0.0560239871270882 0.96439442241644 mirMAP -0.131495002018621 0.00519611005738431 NA NA NA hsa-miR-450b-5p PRKCA -0.0136687538973108 0.983149761399849 0.0560239871270882 0.96439442241644 PITA;mirMAP;miRNATAP -0.165403673620787 0.00202940790109251 NA NA NA hsa-let-7i-5p PRLR -0.200792135853451 0.922018647874073 0.130677603725213 0.899460261123997 miRNATAP -0.749086546015199 7.28886173382936e-05 NA NA NA hsa-miR-146b-5p PRLR -0.402662509440887 0.837510937985091 0.130677603725213 0.899460261123997 mirMAP -0.620798089288789 1.01733730833539e-07 NA NA NA hsa-miR-455-5p PRLR -0.139599153671262 0.865744220236311 0.130677603725213 0.899460261123997 miRanda -0.286241336399817 0.00715002502062815 NA NA NA hsa-miR-106a-5p PTEN -0.203919267842652 0.802213958426804 -0.271908314083064 0.8445980026244 miRNATAP -0.135133363016591 0.00145239050346874 26097565;26318586 miR 106a promotes growth and metastasis of non small cell lung cancer by targeting PTEN; Furthermore the presence of miR-106a was inversely correlated with PTEN in NSCLC tissues; Overall this study suggested that miR-106a inhibited the growth and metastasis of NSCLC cells by decreasing PTEN expression;Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo metastasis; lung squamous cell cancer;prostate cancer hsa-miR-188-5p PTEN -0.568517670542551 0.324820848307954 -0.271908314083064 0.8445980026244 MirTarget;PITA;miRNATAP -0.101903000516257 0.0012689580885123 NA NA NA hsa-miR-29b-3p PTEN -0.104016192263954 0.958988036765397 -0.271908314083064 0.8445980026244 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.118521083357978 0.00549994580612497 26471361;23179556;26063204;21359530 Mechanistically ATDC exerted its oncogenic effects by suppressing miR-29 and subsequent upregulation of DNMT3A leading to DNA methylation and silencing of the tumor suppressor PTEN;Anticancer role of MUC1 aptamer miR 29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation; Our study indicated that Chi-29b chimera can effectively exert antitumor effect through specific delivery of miR-29b into OVCAR-3 tumor cells subsequently reexpressing PTEN gene and inducing cell apoptosis;Furthermore the dual-luciferase reporter assay demonstrated that miR-29b inhibited the expression of the luciferase gene containing the 3'-UTRs of MMP2 and PTEN mRNA;In contrast enhanced miR-29b expression by transfection with pre-miR-29b decreased the expression of PTEN and impaired apoptosis increasing tumor cell migration and invasion; Moreover PTEN was shown to be a direct target of miR-29b and was also shown to contribute to the miR-29b-mediated effects on cell invasion; Modulation of miR-29b altered the role of PTEN involved in cell migration and invasion; Aberrant expression of miR-29b which modulates PTEN expression can contribute to migration invasion and anti-apoptosis ;;;cell migration bladder cancer;ovarian cancer;lung squamous cell cancer;breast cancer hsa-miR-140-5p PTK2 -0.229213026275906 0.847330111738616 0.102201149107646 0.948719505868637 miRanda -0.164830686913929 0.000652694875898043 NA NA NA hsa-miR-379-5p PTK2 0.22044968689524 0.920989389913242 0.102201149107646 0.948719505868637 MirTarget -0.156184628259149 0.000770710925066684 26944318 Moreover miR-379-5p exerted this function by directly targeting focal adhesion kinase FAK 3'-UTR and repressing FAK expression thus leading to suppression of AKT signaling; Furthermore the tumor suppressive effects of miR-379-5p in HCC cells were reversed by activating AKT signaling or restoring FAK expression; In clinical samples of HCC miR-379-5p negatively correlated with FAK which was up-regulated in HCC liver cancer hsa-miR-495-3p PTK2 0.00168200867117596 0.997533662527025 0.102201149107646 0.948719505868637 MirTarget -0.159974281809344 0.00011359084660588 NA NA NA hsa-miR-92b-3p PTK2 -0.569866984318692 0.689321861489779 0.102201149107646 0.948719505868637 miRNATAP -0.129779310920389 3.75554743138018e-05 NA NA NA hsa-miR-126-5p RBL2 0.0815213541035824 0.956637332055185 -0.0691935411360998 0.961846430981863 MirTarget -0.103091093417419 0.00636693014727537 NA NA NA hsa-miR-1287-5p RBL2 -0.39196072316876 0.643886814937723 -0.0691935411360998 0.961846430981863 MirTarget -0.109189265531776 0.00463215553698131 NA NA NA hsa-miR-107 RELN -0.0365118169251648 0.988364120226869 -0.319906539503935 0.643086664812656 miRanda -1.00214569228492 0.000468356629475075 NA NA NA hsa-miR-10a-5p RELN 0.0740585720685925 0.983770933356406 -0.319906539503935 0.643086664812656 miRNAWalker2_validate -0.725376266055571 7.04400916464155e-06 NA NA NA hsa-miR-128-3p RELN -0.442192625156042 0.783886533572187 -0.319906539503935 0.643086664812656 miRNAWalker2_validate;miRTarBase;MirTarget -1.43563215115495 1.00555245577159e-11 NA NA NA hsa-miR-142-3p RELN -0.154235241441331 0.946098054588918 -0.319906539503935 0.643086664812656 miRanda -0.371842730083688 0.00783646411516357 NA NA NA hsa-miR-144-5p RELN -0.300173463942009 0.809668168233345 -0.319906539503935 0.643086664812656 MirTarget -0.477351818539564 5.4757794740366e-05 NA NA NA hsa-miR-15a-5p RELN -0.0674049094129128 0.964835434214123 -0.319906539503935 0.643086664812656 MirTarget;miRNATAP -1.40033186834808 9.45158881833185e-13 NA NA NA hsa-miR-15b-5p RELN -0.272614787130877 0.87096541832188 -0.319906539503935 0.643086664812656 MirTarget;miRNATAP -1.27786122008453 4.67155621475996e-12 NA NA NA hsa-miR-16-5p RELN 0.0135949734723564 0.994476223855607 -0.319906539503935 0.643086664812656 MirTarget;miRNATAP -1.48454606478382 1.78591275906843e-16 NA NA NA hsa-miR-200b-3p RELN -0.426401948379212 0.863957108574195 -0.319906539503935 0.643086664812656 MirTarget;TargetScan -1.16705121199114 1.70108692791797e-13 NA NA NA hsa-miR-200c-3p RELN -0.437282635857873 0.887118598436407 -0.319906539503935 0.643086664812656 MirTarget -1.26416666170967 5.46799020853592e-15 NA NA NA hsa-miR-224-5p RELN -0.240425158977724 0.857351098476517 -0.319906539503935 0.643086664812656 MirTarget -0.409941016275808 0.00101869689236483 NA NA NA hsa-miR-27a-3p RELN -0.123902317731458 0.958804393510999 -0.319906539503935 0.643086664812656 MirTarget;miRNATAP -1.28011275358024 1.95694661578509e-06 NA NA NA hsa-miR-27a-5p RELN -0.199569428508425 0.850152045732979 -0.319906539503935 0.643086664812656 miRNATAP -0.425542448985846 0.00376698603797566 NA NA NA hsa-miR-331-5p RELN -0.450673082073933 0.250361590873666 -0.319906539503935 0.643086664812656 MirTarget;miRNATAP -1.18799009078185 9.16784920886004e-11 NA NA NA hsa-miR-34a-5p RELN -0.50188164870224 0.742034237185732 -0.319906539503935 0.643086664812656 miRNATAP -0.58267751706946 0.00138616747357772 NA NA NA hsa-miR-361-5p RELN -0.138735309928775 0.941495130308343 -0.319906539503935 0.643086664812656 MirTarget;PITA;miRanda -1.04155103708458 0.000295575956493074 NA NA NA hsa-miR-421 RELN -0.182032017078616 0.734704500318599 -0.319906539503935 0.643086664812656 miRanda -0.749931175270235 3.23396658339147e-06 NA NA NA hsa-miR-424-5p RELN 0.247080963500746 0.870154571783568 -0.319906539503935 0.643086664812656 MirTarget;miRNATAP -0.548095523307677 0.000109671624562731 NA NA NA hsa-miR-429 RELN -0.456485631615963 0.806240953400535 -0.319906539503935 0.643086664812656 MirTarget;PITA;miRanda;miRNATAP -1.00214439080369 3.27604631495233e-15 NA NA NA hsa-miR-452-5p RELN -0.0504626418153507 0.973874641360401 -0.319906539503935 0.643086664812656 MirTarget -0.450523787317888 0.00616892854412279 NA NA NA hsa-miR-455-3p RELN -0.356341681711462 0.824635754440661 -0.319906539503935 0.643086664812656 PITA -0.786200779962386 1.84118138022862e-08 NA NA NA hsa-miR-582-5p RELN -0.399450205475138 0.581227478860085 -0.319906539503935 0.643086664812656 MirTarget;PITA -0.776177885538975 2.21746847448747e-05 NA NA NA hsa-miR-589-3p RELN -0.835836305204965 0.0112001563801511 -0.319906539503935 0.643086664812656 MirTarget -0.704984333295977 5.36137535737162e-08 NA NA NA hsa-miR-590-3p RELN -0.279244755376859 0.59126669933662 -0.319906539503935 0.643086664812656 miRanda;miRNATAP -1.17665335148893 4.12414163908289e-19 NA NA NA hsa-miR-935 RELN 0.0536667023984385 0.939418255464024 -0.319906539503935 0.643086664812656 MirTarget;PITA;miRNATAP -0.266144775455592 0.00024937150072216 NA NA NA hsa-miR-142-3p RHEB -0.154235241441331 0.946098054588918 0.106843351921338 0.940209768628131 MirTarget;PITA;miRanda;miRNATAP -0.100218439588093 0.000176553474997339 NA NA NA hsa-miR-155-5p RHEB -0.407235807706004 0.828669616718496 0.106843351921338 0.940209768628131 miRNAWalker2_validate;miRNATAP -0.117250793253776 0.000276574591106519 NA NA NA hsa-miR-330-3p RHEB 0.00298687748748416 0.994504006750491 0.106843351921338 0.940209768628131 MirTarget -0.119171087374429 0.0008998989811971 NA NA NA hsa-miR-744-5p RHEB -0.53616420856114 0.593323569743084 0.106843351921338 0.940209768628131 miRNAWalker2_validate -0.141429247323005 0.000155814698761217 NA NA NA hsa-miR-181c-5p RPS6KB1 0.042951891660695 0.969159991881861 -0.0923775363192672 0.935872394288502 MirTarget;miRNATAP -0.105699068327426 8.16023080416683e-05 NA NA NA hsa-miR-30a-5p RPS6KB1 0.219472325612346 0.933954023293816 -0.0923775363192672 0.935872394288502 mirMAP;miRNATAP -0.128600939153832 0.00108269533119504 NA NA NA hsa-miR-361-5p SGK1 -0.138735309928775 0.941495130308343 0.0754602827738058 0.949070082699575 miRanda -0.430487871254978 0.000329880054660055 NA NA NA hsa-miR-330-5p SGK2 -0.283418953659271 0.815687101334695 0.322609139436482 0.734013031404795 miRanda -0.501620274041876 0.00134399229359652 NA NA NA hsa-miR-126-5p SGK3 0.0815213541035824 0.956637332055185 0.0481879393366924 0.960110255418107 mirMAP -0.157216543321108 0.00383913702903554 NA NA NA hsa-miR-142-5p SGK3 -0.118920788314118 0.929665277963083 0.0481879393366924 0.960110255418107 mirMAP -0.118276949705292 0.00186246740479207 NA NA NA hsa-miR-27a-3p SOS1 -0.123902317731458 0.958804393510999 -0.133663949462885 0.918709253182528 MirTarget;miRNATAP -0.128294784600539 0.000637917145382412 NA NA NA hsa-miR-369-3p SOS1 0.116576891957687 0.83230082995912 -0.133663949462885 0.918709253182528 miRNATAP -0.135959090885724 6.65395075102377e-09 NA NA NA hsa-miR-381-3p SOS1 0.0562600264188893 0.966895219811624 -0.133663949462885 0.918709253182528 MirTarget -0.100940916746464 0.00276528516676685 NA NA NA hsa-miR-130a-3p SOS2 0.0910074087716906 0.929098200371948 -0.0380982568268919 0.974772477648122 miRNATAP -0.106710417537474 0.00163707990890625 NA NA NA hsa-miR-146b-5p SOS2 -0.402662509440887 0.837510937985091 -0.0380982568268919 0.974772477648122 miRanda -0.166193413119417 6.48354241761314e-06 NA NA NA hsa-miR-154-5p SOS2 -0.058936877201993 0.864854818862396 -0.0380982568268919 0.974772477648122 miRNATAP -0.116649989146456 0.00011300613484555 NA NA NA hsa-miR-493-5p SOS2 0.229930075372342 0.731979520100109 -0.0380982568268919 0.974772477648122 miRNATAP -0.128957133953108 0.00138950642379943 NA NA NA hsa-miR-146a-5p SPP1 -0.581292803346906 0.73685134936757 0.669246062123371 0.66257678869958 miRNAWalker2_validate -0.729812417749298 1.0020470353058e-06 NA NA NA hsa-miR-335-5p SPP1 -0.0284895175847679 0.973380867832231 0.669246062123371 0.66257678869958 miRNAWalker2_validate -1.06246538934 1.89142868365329e-11 NA NA NA hsa-miR-362-3p SPP1 -0.721040238345347 0.0345881362485733 0.669246062123371 0.66257678869958 miRanda -0.583244197005426 5.85579288872276e-05 NA NA NA hsa-miR-577 SPP1 -1.06238199218774 0.326056761787754 0.669246062123371 0.66257678869958 miRNATAP -0.375429798045949 5.14611773010192e-05 NA NA NA hsa-miR-590-3p SPP1 -0.279244755376859 0.59126669933662 0.669246062123371 0.66257678869958 miRanda -0.792675598607045 6.61380515722821e-08 NA NA NA hsa-miR-92b-3p SYK -0.569866984318692 0.689321861489779 0.101461041607251 0.94708690104375 mirMAP -0.130593601755731 0.000571061508172303 NA NA NA hsa-miR-29b-3p TCL1A -0.104016192263954 0.958988036765397 -0.290695873494629 0.783981681003283 miRNAWalker2_validate;miRTarBase -0.569097061724499 0.00535668159893605 NA NA NA hsa-miR-940 TCL1A -0.225788347550697 0.680055767105815 -0.290695873494629 0.783981681003283 miRNATAP -0.443033823819949 0.00253167252085642 NA NA NA hsa-miR-126-3p TEK -0.106293136341574 0.963670566555251 -0.0316898392412814 0.959248838487476 miRNAWalker2_validate;miRTarBase -0.324851412197732 0.00279806594030343 NA NA NA hsa-miR-421 TEK -0.182032017078616 0.734704500318599 -0.0316898392412814 0.959248838487476 miRanda -0.384088160282768 2.49335939254388e-06 NA NA NA hsa-miR-491-3p TEK -0.513850326596847 0.137836285146052 -0.0316898392412814 0.959248838487476 PITA -0.352185084466575 7.51731532906315e-07 NA NA NA hsa-let-7a-3p THBS1 -0.215598045625677 0.85543299203799 0.37603535083018 0.836094799366458 mirMAP -0.41118832969956 1.17692621132587e-05 NA NA NA hsa-let-7d-5p THBS1 -0.139747701175051 0.934164162708487 0.37603535083018 0.836094799366458 miRNAWalker2_validate -0.719338910529418 1.28583403501255e-07 NA NA NA hsa-let-7f-1-3p THBS1 -0.31101436822914 0.693407210545374 0.37603535083018 0.836094799366458 mirMAP -0.463711142054319 0.00032640810606793 NA NA NA hsa-miR-1304-5p THBS1 -0.497887681787993 0.163079003594721 0.37603535083018 0.836094799366458 MirTarget -0.290009661016067 3.21252145412814e-06 NA NA NA hsa-miR-151a-3p THBS1 -0.0829874640636401 0.975334671097605 0.37603535083018 0.836094799366458 MirTarget -0.595363062195978 1.26067921863967e-06 NA NA NA hsa-miR-16-1-3p THBS1 0.151694812889216 0.733736501874638 0.37603535083018 0.836094799366458 MirTarget -0.331707770084304 8.70940308366408e-06 NA NA NA hsa-miR-17-5p THBS1 -0.175448849583061 0.934544015912731 0.37603535083018 0.836094799366458 miRNAWalker2_validate -0.542287170978251 2.21455240955436e-14 NA NA NA hsa-miR-182-5p THBS1 -0.104238497940557 0.973380614062243 0.37603535083018 0.836094799366458 MirTarget -0.440739082912491 1.8073484994174e-09 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 -0.318786974828757 0.85412722938961 0.37603535083018 0.836094799366458 mirMAP -0.608952798433662 2.47915506371775e-07 NA NA NA hsa-miR-18a-5p THBS1 -0.498318455303917 0.61264091975585 0.37603535083018 0.836094799366458 MirTarget -0.385312140125092 2.00045829060915e-10 NA NA NA hsa-miR-18b-5p THBS1 -0.0473300652227538 0.899981261531446 0.37603535083018 0.836094799366458 MirTarget -0.339766615395865 1.37777042193251e-08 NA NA NA hsa-miR-19a-3p THBS1 -0.206793507801887 0.844637784802316 0.37603535083018 0.836094799366458 MirTarget;mirMAP -0.393321940396923 1.51728383944411e-08 NA NA NA hsa-miR-19b-3p THBS1 -0.0268530183621474 0.986656783046572 0.37603535083018 0.836094799366458 MirTarget;mirMAP -0.500532481435115 1.42800824280983e-09 NA NA NA hsa-miR-200a-5p THBS1 -0.671005453811576 0.78126028567661 0.37603535083018 0.836094799366458 MirTarget -0.522682977399615 3.8018258765331e-12 NA NA NA hsa-miR-200b-5p THBS1 -0.502275384207405 0.722255155236927 0.37603535083018 0.836094799366458 MirTarget -0.585054033537504 1.31516173644716e-15 NA NA NA hsa-miR-20a-5p THBS1 -0.179153323927949 0.928118119139752 0.37603535083018 0.836094799366458 miRNAWalker2_validate -0.470580652824932 3.57671741010858e-11 NA NA NA hsa-miR-29b-1-5p THBS1 -0.642348119412534 0.293891497238796 0.37603535083018 0.836094799366458 mirMAP -0.369904190544962 3.6333073142916e-10 NA NA NA hsa-miR-32-5p THBS1 -0.05993267619119 0.952975951594959 0.37603535083018 0.836094799366458 mirMAP -0.488625825442418 1.82876859746085e-09 NA NA NA hsa-miR-335-3p THBS1 -0.244830745789445 0.88450019116631 0.37603535083018 0.836094799366458 mirMAP -0.400957216960711 1.65646707648448e-07 NA NA NA hsa-miR-33a-3p THBS1 -0.794543849238581 0.0105203072007922 0.37603535083018 0.836094799366458 MirTarget;mirMAP -0.229718231056134 0.0015302648509945 NA NA NA hsa-miR-375 THBS1 -0.690952835064582 0.831716365337668 0.37603535083018 0.836094799366458 miRanda -0.238796936612876 8.72515902203638e-06 NA NA NA hsa-miR-421 THBS1 -0.182032017078616 0.734704500318599 0.37603535083018 0.836094799366458 miRanda -0.366836315247693 5.97643249097868e-06 NA NA NA hsa-miR-500a-5p THBS1 -0.71978560736831 0.188073776225276 0.37603535083018 0.836094799366458 mirMAP -0.361271149320601 5.14215756637248e-07 NA NA NA hsa-miR-576-5p THBS1 -0.506413219377403 0.417187951364173 0.37603535083018 0.836094799366458 mirMAP -0.445801292946502 1.13145649504503e-07 NA NA NA hsa-miR-577 THBS1 -1.06238199218774 0.326056761787754 0.37603535083018 0.836094799366458 mirMAP -0.320712203502624 2.98965890278874e-14 NA NA NA hsa-miR-589-3p THBS1 -0.835836305204965 0.0112001563801511 0.37603535083018 0.836094799366458 mirMAP -0.244790151703082 0.00022198427277421 NA NA NA hsa-miR-590-3p THBS1 -0.279244755376859 0.59126669933662 0.37603535083018 0.836094799366458 miRanda -0.425999295779669 7.7644420709461e-10 NA NA NA hsa-miR-590-5p THBS1 -0.547819833829572 0.472735645776647 0.37603535083018 0.836094799366458 miRanda;mirMAP -0.499886795402802 5.25392011734012e-12 NA NA NA hsa-miR-629-3p THBS1 -0.495402745812008 0.333967382214384 0.37603535083018 0.836094799366458 MirTarget -0.294242028378809 1.53263223284399e-05 NA NA NA hsa-miR-671-5p THBS1 -0.373754118103105 0.411207779636977 0.37603535083018 0.836094799366458 MirTarget -0.367576368626689 2.96555063023917e-05 NA NA NA hsa-miR-7-1-3p THBS1 -0.462485777435991 0.665899751398166 0.37603535083018 0.836094799366458 MirTarget;mirMAP -0.430026468156785 1.63430969689822e-07 NA NA NA hsa-miR-92a-3p THBS1 0.0278830870766349 0.993247426671713 0.37603535083018 0.836094799366458 miRNAWalker2_validate -0.558155146051118 4.90135167178647e-11 NA NA NA hsa-miR-940 THBS1 -0.225788347550697 0.680055767105815 0.37603535083018 0.836094799366458 MirTarget -0.23198243446538 0.000141164521779727 NA NA NA hsa-miR-98-5p THBS1 -0.168162186023221 0.898802461503524 0.37603535083018 0.836094799366458 miRNAWalker2_validate -0.47060302964344 4.45298152570222e-05 NA NA NA hsa-miR-106a-5p THBS2 -0.203919267842652 0.802213958426804 0.512973725842095 0.747624438837408 MirTarget -0.851654146469256 7.99248680269072e-10 NA NA NA hsa-miR-106b-5p THBS2 -0.297128724729339 0.869294443540749 0.512973725842095 0.747624438837408 MirTarget -1.31065064830243 2.29643442187507e-17 NA NA NA hsa-miR-16-2-3p THBS2 -0.36717860153421 0.546850726070016 0.512973725842095 0.747624438837408 mirMAP -0.890780906333485 1.98480833071713e-12 NA NA NA hsa-miR-17-5p THBS2 -0.175448849583061 0.934544015912731 0.512973725842095 0.747624438837408 MirTarget;TargetScan -0.787511112093001 9.83722799272829e-11 NA NA NA hsa-miR-182-5p THBS2 -0.104238497940557 0.973380614062243 0.512973725842095 0.747624438837408 MirTarget;miRNATAP -0.642538580791181 2.57451760948422e-07 NA NA NA hsa-miR-20a-5p THBS2 -0.179153323927949 0.928118119139752 0.512973725842095 0.747624438837408 MirTarget -0.673455171264225 2.91261086457628e-08 NA NA NA hsa-miR-29a-3p THBS2 0.01127474410284 0.996977020481272 0.512973725842095 0.747624438837408 MirTarget -1.18129443893629 1.02247283192754e-10 NA NA NA hsa-miR-29b-3p THBS2 -0.104016192263954 0.958988036765397 0.512973725842095 0.747624438837408 MirTarget -0.909499440644144 4.62769211289439e-11 NA NA NA hsa-miR-32-3p THBS2 -0.568003960723004 0.13133163420273 0.512973725842095 0.747624438837408 miRNATAP -0.786486825619221 1.1398385290571e-15 NA NA NA hsa-miR-320a THBS2 -0.416546433767628 0.840202138616422 0.512973725842095 0.747624438837408 mirMAP -0.571379046653204 0.00087003518708632 NA NA NA hsa-miR-320b THBS2 -0.23561798088153 0.859222532827992 0.512973725842095 0.747624438837408 mirMAP -0.471961507021475 0.00223735071513856 NA NA NA hsa-miR-335-3p THBS2 -0.244830745789445 0.88450019116631 0.512973725842095 0.747624438837408 MirTarget;mirMAP -0.703746972360779 4.43972411067165e-08 NA NA NA hsa-miR-582-3p THBS2 -0.2334649592375 0.897678119160318 0.512973725842095 0.747624438837408 miRNATAP -0.656690063746532 1.08413842236148e-05 NA NA NA hsa-miR-590-3p THBS2 -0.279244755376859 0.59126669933662 0.512973725842095 0.747624438837408 miRanda;mirMAP -0.900199337088959 2.09842897436902e-15 NA NA NA hsa-miR-590-5p THBS2 -0.547819833829572 0.472735645776647 0.512973725842095 0.747624438837408 miRanda -0.88884040137609 2.20379084859741e-13 NA NA NA hsa-miR-7-1-3p THBS2 -0.462485777435991 0.665899751398166 0.512973725842095 0.747624438837408 MirTarget;mirMAP -1.00049947584379 8.15766069112558e-14 NA NA NA hsa-miR-93-5p THBS2 -0.611073677204699 0.825297877093193 0.512973725842095 0.747624438837408 MirTarget -0.891994984700629 4.66098494257318e-09 NA NA NA hsa-miR-96-5p THBS2 0.0854810872029343 0.923087820185031 0.512973725842095 0.747624438837408 TargetScan;miRNATAP -0.865547827377968 1.90076948358082e-13 NA NA NA hsa-miR-335-5p THBS3 -0.0284895175847679 0.973380867832231 0.34753150858589 0.715668820853316 miRNAWalker2_validate -0.191375500230702 5.59757339988889e-05 NA NA NA hsa-miR-550a-5p THBS3 -0.390865630073894 0.535659273352227 0.34753150858589 0.715668820853316 MirTarget -0.187184804477319 4.78131254437415e-05 NA NA NA hsa-miR-142-3p THBS4 -0.154235241441331 0.946098054588918 1.17780911963164 0.211096888976341 miRanda -0.726139570798281 0.000407777196818855 NA NA NA hsa-miR-320a THBS4 -0.416546433767628 0.840202138616422 1.17780911963164 0.211096888976341 miRanda -1.15551249685449 0.000108861527322511 NA NA NA hsa-miR-320b THBS4 -0.23561798088153 0.859222532827992 1.17780911963164 0.211096888976341 miRanda -0.71078130063873 0.00861626608480447 NA NA NA hsa-miR-30a-5p THEM4 0.219472325612346 0.933954023293816 0.00651656143347834 0.994012395071284 miRNAWalker2_validate -0.185973902864249 0.00367871125407665 NA NA NA hsa-miR-106b-5p TLR2 -0.297128724729339 0.869294443540749 -0.0237538182702957 0.97201516064894 miRNAWalker2_validate -0.519474049637736 1.19177606646925e-09 NA NA NA hsa-miR-19a-3p TLR2 -0.206793507801887 0.844637784802316 -0.0237538182702957 0.97201516064894 miRNAWalker2_validate;miRTarBase -0.255495094490081 5.47762426738395e-05 NA NA NA hsa-miR-19b-3p TLR2 -0.0268530183621474 0.986656783046572 -0.0237538182702957 0.97201516064894 miRNAWalker2_validate;miRTarBase -0.318211727164326 2.58245470937521e-05 NA NA NA hsa-miR-320a TLR2 -0.416546433767628 0.840202138616422 -0.0237538182702957 0.97201516064894 miRanda -0.282844755416561 0.0019746731628007 NA NA NA hsa-miR-320b TLR2 -0.23561798088153 0.859222532827992 -0.0237538182702957 0.97201516064894 miRanda -0.218981961357049 0.00780990959013083 NA NA NA hsa-miR-335-5p TLR2 -0.0284895175847679 0.973380867832231 -0.0237538182702957 0.97201516064894 miRNAWalker2_validate -0.414206968877669 1.20598233042981e-09 NA NA NA hsa-miR-590-3p TLR2 -0.279244755376859 0.59126669933662 -0.0237538182702957 0.97201516064894 miRanda -0.310863645461667 7.90594538317416e-07 NA NA NA hsa-let-7f-2-3p TLR4 -0.0455032713433074 0.882115725419367 -0.11559353759217 0.911736407512477 MirTarget -0.268689212966683 0.00129118885494541 NA NA NA hsa-miR-17-5p TLR4 -0.175448849583061 0.934544015912731 -0.11559353759217 0.911736407512477 TargetScan -0.244584272088849 0.00400804150622252 NA NA NA hsa-miR-369-3p TLR4 0.116576891957687 0.83230082995912 -0.11559353759217 0.911736407512477 miRNATAP -0.257312303020864 0.00982295433675632 NA NA NA hsa-miR-590-3p TLR4 -0.279244755376859 0.59126669933662 -0.11559353759217 0.911736407512477 miRanda;mirMAP -0.343555076589139 1.81560793431496e-05 NA NA NA hsa-miR-590-5p TLR4 -0.547819833829572 0.472735645776647 -0.11559353759217 0.911736407512477 miRanda -0.44045258830693 1.51341026785016e-07 NA NA NA hsa-miR-7-5p TLR4 0.209645143210379 0.773705612298441 -0.11559353759217 0.911736407512477 MirTarget -0.292365199686125 9.57598739326274e-07 24004462 Our recent evidence showed that Toll like receptor 9 TLR9 signaling could enhance the growth and metastatic potential of human lung cancer cells through repressing microRNA-7 miR-7 expression lung cancer hsa-miR-335-5p TNC -0.0284895175847679 0.973380867832231 0.41660135919619 0.7854957806632 miRNAWalker2_validate;miRTarBase -1.00869915967278 2.93761596900861e-21 NA NA NA hsa-miR-425-5p TNC -0.354606074344121 0.845979106734409 0.41660135919619 0.7854957806632 MirTarget -0.850714410407433 1.10857894452288e-14 NA NA NA hsa-miR-501-5p TNC -0.834032628506285 0.0582725160418523 0.41660135919619 0.7854957806632 miRNATAP -0.382555611629365 4.42705502348279e-05 NA NA NA hsa-miR-505-5p TNC -0.555858818875454 0.317679205488749 0.41660135919619 0.7854957806632 MirTarget -0.522194209750158 2.91395016538233e-05 NA NA NA hsa-miR-590-3p TNC -0.279244755376859 0.59126669933662 0.41660135919619 0.7854957806632 miRanda -0.733783219639293 3.83724424122451e-13 NA NA NA hsa-miR-140-5p TNN -0.229213026275906 0.847330111738616 0.410795177435694 0.50408039720452 PITA;miRanda -0.535148804233633 0.00103791458854402 NA NA NA hsa-miR-491-3p TNN -0.513850326596847 0.137836285146052 0.410795177435694 0.50408039720452 miRNATAP -0.312722146991161 0.000790383901768409 NA NA NA hsa-miR-30b-5p TNXB -0.0121430518253582 0.994622896704513 -0.0367987296844681 0.965522103704427 mirMAP -0.634217897218171 1.48182481652565e-07 NA NA NA hsa-miR-30c-5p TNXB -0.298383882401475 0.865809030482001 -0.0367987296844681 0.965522103704427 mirMAP -0.617252352332955 0.000455733905351202 NA NA NA hsa-miR-1-3p VEGFA 0.743297777604706 0.502740755603748 0.44291481761107 0.794175304752332 MirTarget -0.116378239250321 6.72225230732928e-05 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-129-5p VEGFA 0.268577986151378 0.553351908525147 0.44291481761107 0.794175304752332 miRanda -0.105916187808699 0.00205982654647779 NA NA NA hsa-miR-150-5p VEGFA -0.380115629777847 0.838788934042507 0.44291481761107 0.794175304752332 miRNAWalker2_validate;miRTarBase -0.105332454174453 0.00212185781504366 NA NA NA hsa-miR-195-5p VEGFA 0.343201952346823 0.749622318650888 0.44291481761107 0.794175304752332 miRNAWalker2_validate;miRTarBase;MirTarget -0.17069720152047 0.00113687245030063 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-342-3p VEGFA -0.371626144515113 0.77313668985267 0.44291481761107 0.794175304752332 miRanda;miRNATAP -0.180071200249696 0.000461735316514135 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-642a-5p VEGFB 0.00605485088835034 0.98806034007652 0.186752095884063 0.879413489616489 MirTarget -0.110252259736901 4.41057201692337e-05 NA NA NA hsa-miR-128-3p VEGFC -0.442192625156042 0.783886533572187 0.47579727228228 0.306081464218048 miRNAWalker2_validate;MirTarget -0.703841140515502 1.79431671849186e-11 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC -0.36717860153421 0.546850726070016 0.47579727228228 0.306081464218048 MirTarget -0.577975043513837 2.82952367749584e-15 NA NA NA hsa-miR-27a-3p VEGFC -0.123902317731458 0.958804393510999 0.47579727228228 0.306081464218048 MirTarget -0.506585140692086 0.000168779320063404 NA NA NA hsa-miR-374a-5p VEGFC -0.343007247142618 0.766921280269271 0.47579727228228 0.306081464218048 MirTarget -0.563100644665433 2.34179983517396e-06 NA NA NA hsa-miR-374b-5p VEGFC -0.285682091626878 0.83569830479965 0.47579727228228 0.306081464218048 MirTarget -0.605816787637354 1.34969594387806e-07 NA NA NA hsa-miR-590-3p VEGFC -0.279244755376859 0.59126669933662 0.47579727228228 0.306081464218048 miRanda -0.48851698816486 3.73378001214407e-13 NA NA NA hsa-miR-335-5p VTN -0.0284895175847679 0.973380867832231 -0.410847324082984 0.613423028620475 miRNAWalker2_validate -0.55108595556061 1.25425497666892e-06 NA NA NA hsa-miR-15a-5p VWF -0.0674049094129128 0.964835434214123 0.193838783141403 0.899738199682257 mirMAP -0.435268094268183 8.320872333978e-06 NA NA NA hsa-miR-15b-5p VWF -0.272614787130877 0.87096541832188 0.193838783141403 0.899738199682257 mirMAP -0.427486400098434 2.96600940384562e-06 NA NA NA hsa-miR-16-5p VWF 0.0135949734723564 0.994476223855607 0.193838783141403 0.899738199682257 mirMAP -0.521688410050237 6.81079672150147e-09 NA NA NA hsa-miR-424-5p VWF 0.247080963500746 0.870154571783568 0.193838783141403 0.899738199682257 mirMAP -0.274131847002817 5.60846108221197e-05 NA NA NA hsa-miR-429 VWF -0.456485631615963 0.806240953400535 0.193838783141403 0.899738199682257 miRNATAP -0.409856953182843 5.28304401174033e-11 NA NA NA hsa-miR-132-3p YWHAB -0.244143673573889 0.871752726220643 0.268492923780645 0.897700515695515 MirTarget -0.18806375055171 0.00189416692640873 NA NA NA hsa-miR-330-3p YWHAB 0.00298687748748416 0.994504006750491 0.268492923780645 0.897700515695515 MirTarget;PITA -0.117570493699089 0.00654102490230821 NA NA NA hsa-miR-100-5p YWHAE 0.0230258429671419 0.992818348620337 -0.138575101196187 0.946623595756686 miRNAWalker2_validate -0.120562901672456 8.58625884415223e-06 NA NA NA hsa-miR-199a-3p YWHAE 0.0782166873040424 0.973766909565326 -0.138575101196187 0.946623595756686 MirTarget;PITA;miRNATAP -0.109292308891936 0.00757704489929994 NA NA NA hsa-miR-199a-5p YWHAE 0.157247797504494 0.935797462797012 -0.138575101196187 0.946623595756686 miRanda -0.12397348360088 0.00101562574044864 NA NA NA hsa-miR-199b-3p YWHAE 0.0780653337513897 0.973815251150337 -0.138575101196187 0.946623595756686 MirTarget;PITA;miRNATAP -0.109211349134326 0.00762217119708688 NA NA NA hsa-miR-30a-3p YWHAE 0.250338313897394 0.917094926793447 -0.138575101196187 0.946623595756686 miRNAWalker2_validate;MirTarget;miRNATAP -0.176312896763582 0.000106750398372577 NA NA NA hsa-miR-30a-5p YWHAE 0.219472325612346 0.933954023293816 -0.138575101196187 0.946623595756686 miRNAWalker2_validate -0.227892668616782 9.06521083943401e-06 NA NA NA hsa-miR-23b-3p YWHAG -0.10822254818704 0.961352920317636 -0.0391520245774739 0.983081423028695 MirTarget;miRNATAP -0.115715051130517 0.00775699813228171 NA NA NA hsa-miR-30e-5p YWHAG -0.0657075181381011 0.979684509181941 -0.0391520245774739 0.983081423028695 miRNATAP -0.15442784470344 2.71338646255962e-05 NA NA NA hsa-miR-139-5p YWHAQ -0.0810891026597322 0.928690377743652 0.0826476345455838 0.965635074886716 MirTarget;PITA;miRanda;miRNATAP -0.102836765005167 0.00026663023384852 NA NA NA hsa-miR-140-5p YWHAQ -0.229213026275906 0.847330111738616 0.0826476345455838 0.965635074886716 miRanda -0.131618682474264 0.00107757909343137 NA NA NA hsa-miR-145-3p YWHAQ 0.134827892912136 0.913156302847575 0.0826476345455838 0.965635074886716 MirTarget;miRNATAP -0.127870021749012 9.64101490771534e-05 NA NA NA hsa-miR-27a-3p YWHAQ -0.123902317731458 0.958804393510999 0.0826476345455838 0.965635074886716 MirTarget -0.121677680598632 0.00581404335298484 NA NA NA hsa-miR-27b-3p YWHAQ -0.14277121795778 0.951937409841932 0.0826476345455838 0.965635074886716 MirTarget -0.186553804415952 0.000211073817991096 NA NA NA hsa-miR-328-3p YWHAQ -0.27090542057371 0.758001839490036 0.0826476345455838 0.965635074886716 miRNAWalker2_validate -0.142782029703957 1.81063391745289e-06 NA NA NA hsa-miR-497-5p YWHAQ -0.0120217191428731 0.989147225742026 0.0826476345455838 0.965635074886716 MirTarget;miRNATAP -0.187258093691752 1.06417785486781e-08 NA NA NA hsa-miR-199a-3p YWHAZ 0.0782166873040424 0.973766909565326 -0.0576420671060323 0.980589660363914 MirTarget -0.114139275111848 0.00473898120199714 NA NA NA hsa-miR-199a-5p YWHAZ 0.157247797504494 0.935797462797012 -0.0576420671060323 0.980589660363914 miRanda -0.120463700457026 0.00124102929646691 NA NA NA hsa-miR-199b-3p YWHAZ 0.0780653337513897 0.973815251150337 -0.0576420671060323 0.980589660363914 MirTarget -0.114089745391343 0.00475721105978957 NA NA NA hsa-miR-22-3p YWHAZ 0.0592693913158495 0.986564295498741 -0.0576420671060323 0.980589660363914 MirTarget -0.160711801138276 0.0060701669558579 NA NA NA hsa-miR-30e-5p YWHAZ -0.0657075181381011 0.979684509181941 -0.0576420671060323 0.980589660363914 MirTarget;miRNATAP -0.140789168239452 0.00739940560791832 NA NA NA hsa-miR-328-3p YWHAZ -0.27090542057371 0.758001839490036 -0.0576420671060323 0.980589660363914 MirTarget -0.1359967552498 0.000235753753264675 NA NA NA hsa-miR-34c-5p YWHAZ -0.018707656771723 0.952788306178575 -0.0576420671060323 0.980589660363914 miRanda -0.10452079235571 0.00184231244437824 NA NA NA hsa-miR-708-3p YWHAZ 0.137785606206693 0.896980471394499 -0.0576420671060323 0.980589660363914 mirMAP -0.102981853394496 0.00113142770330167 NA NA NA