miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106a-5p BMP2 3.98693608217557 9.37722470816656e-07 0.595740898970527 0.596139083918881 miRNATAP -0.284756722505656 0.000196543267629134 NA NA NA hsa-miR-362-3p BMP2 0.679952485897744 0.226148468488576 0.595740898970527 0.596139083918881 miRanda -0.390686913840248 0.000600723221602875 NA NA NA hsa-miR-378c BMP2 0.449601775771001 0.4993814483956 0.595740898970527 0.596139083918881 miRNATAP -0.281129605798991 0.00340183029023861 NA NA NA hsa-miR-429 BMP2 6.39965293994036 1.96920201593608e-18 0.595740898970527 0.596139083918881 miRNATAP -0.316552444908905 0.000105772353880714 NA NA NA hsa-miR-125a-3p BMP7 -0.0748960586927341 0.920735897434087 2.47007870640865 0.141831667873887 miRanda -0.602397019762289 1.60854190307016e-06 NA NA NA hsa-miR-30a-5p BMP7 -0.768430903969183 0.320487552854215 2.47007870640865 0.141831667873887 mirMAP;miRNATAP -0.837637094666436 2.22227369883976e-12 NA NA NA hsa-miR-338-3p BMP7 0.447551118940466 0.558485097370031 2.47007870640865 0.141831667873887 miRanda -0.675850252283759 3.5099234776835e-08 NA NA NA hsa-miR-150-5p CTNNB1 1.76769157530064 0.0593795975117846 -0.598740867811971 0.152216124887482 MirTarget -0.1161821301588 2.89988026655084e-06 NA NA NA hsa-miR-155-5p CTNNB1 2.81443182173772 7.42530504828797e-05 -0.598740867811971 0.152216124887482 miRNAWalker2_validate -0.166081896357714 3.05605612118335e-07 NA NA NA hsa-miR-221-3p CTNNB1 0.94082283577318 0.174749164179978 -0.598740867811971 0.152216124887482 miRNAWalker2_validate -0.15386110666748 5.20471332163171e-06 NA NA NA hsa-miR-330-3p CTNNB1 2.49094236945806 0.000129367003214715 -0.598740867811971 0.152216124887482 MirTarget;PITA;miRNATAP -0.113866447624475 0.00159137187547744 NA NA NA hsa-miR-590-3p CTNNB1 2.35429565068338 2.79601879608564e-06 -0.598740867811971 0.152216124887482 miRanda -0.159536768797246 0.00059253265161602 NA NA NA hsa-miR-15b-5p EPB41L5 3.32329949959268 8.40210501034588e-13 -1.32501741875163 0.0198912428649371 MirTarget -0.207373055575847 0.00207616781519625 NA NA NA hsa-miR-16-1-3p EPB41L5 2.83281226969693 7.54359864580834e-09 -1.32501741875163 0.0198912428649371 mirMAP -0.176479783216191 0.0064160468360107 NA NA NA hsa-miR-16-2-3p EPB41L5 3.79845098071094 1.49120139344659e-13 -1.32501741875163 0.0198912428649371 mirMAP -0.259211381599068 1.60128254041025e-05 NA NA NA hsa-miR-16-5p EPB41L5 2.93575808220754 2.15436817162977e-10 -1.32501741875163 0.0198912428649371 MirTarget -0.209728838253719 0.00212592286170757 NA NA NA hsa-miR-33b-5p EPB41L5 4.77891217497671 1.33695107675057e-08 -1.32501741875163 0.0198912428649371 mirMAP -0.137906103089663 0.000230233177754753 NA NA NA hsa-miR-192-5p FAM83D 1.77716187978541 0.113485496183047 6.15156612873872 1.01302577915699e-27 miRNAWalker2_validate -0.105775689475445 0.000633202817606027 NA NA NA hsa-miR-146b-5p FGFR2 1.87569569182453 0.000737241069698886 -1.54795077473676 0.070591459239545 miRanda -0.298378342872546 0.000592636062336762 NA NA NA hsa-miR-330-5p FGFR2 2.25110496739954 0.000275527655397415 -1.54795077473676 0.070591459239545 miRanda -0.389349119984991 4.06955034955631e-07 NA NA NA hsa-miR-338-3p FGFR2 0.447551118940466 0.558485097370031 -1.54795077473676 0.070591459239545 miRanda;miRNATAP -0.19939075618371 0.00167905513044275 NA NA NA hsa-miR-181c-5p GSK3B -0.302833440762172 0.537532549455539 0.984264794042029 0.00614784819440891 mirMAP -0.115369483842179 0.00582165998524454 NA NA NA hsa-miR-30a-3p GSK3B -1.22212086897848 0.167565797592104 0.984264794042029 0.00614784819440891 miRNATAP -0.11517576765646 3.57050461951731e-07 NA NA NA hsa-miR-30d-3p GSK3B -0.0740421896025512 0.857423650167556 0.984264794042029 0.00614784819440891 miRNATAP -0.217356687168476 1.21966436788369e-05 NA NA NA hsa-miR-320c GSK3B -0.10618808730545 0.854002814666472 0.984264794042029 0.00614784819440891 miRanda;mirMAP -0.100605875350465 0.00537879672016752 NA NA NA hsa-miR-362-5p GSK3B -1.22309034685697 0.0452665543907975 0.984264794042029 0.00614784819440891 miRNATAP -0.116235509089146 0.000473661337943669 NA NA NA hsa-let-7f-1-3p HGF 1.61507869803314 0.00069342464777815 -3.90177127926037 9.33819406271226e-05 mirMAP -0.537655519322627 7.00715676350499e-06 NA NA NA hsa-miR-141-3p HGF 7.30474126597325 1.45115996357606e-24 -3.90177127926037 9.33819406271226e-05 MirTarget;TargetScan -0.407936076663434 1.88518993661496e-08 NA NA NA hsa-miR-200a-3p HGF 6.336081120041 4.024313571871e-16 -3.90177127926037 9.33819406271226e-05 MirTarget -0.280888359064684 5.08617365666383e-05 NA NA NA hsa-miR-203a-3p HGF 6.35084246337388 7.89944323347948e-08 -3.90177127926037 9.33819406271226e-05 MirTarget -0.204595731578258 1.21386978961366e-05 NA NA NA hsa-miR-335-3p HGF 1.19503568251824 0.0938852560631551 -3.90177127926037 9.33819406271226e-05 mirMAP -0.273560280003382 0.00062323466706546 NA NA NA hsa-miR-33a-3p HGF 2.06269680799532 0.00156436055383943 -3.90177127926037 9.33819406271226e-05 mirMAP -0.326603422809417 0.000183515930533633 NA NA NA hsa-miR-34c-5p HGF 2.64675661251039 0.0157394735757952 -3.90177127926037 9.33819406271226e-05 miRanda -0.139605145794652 0.00726083502207088 NA NA NA hsa-miR-429 HGF 6.39965293994036 1.96920201593608e-18 -3.90177127926037 9.33819406271226e-05 miRanda -0.31974260136447 1.24182213618931e-05 NA NA NA hsa-miR-590-5p HGF 1.51400888103768 0.0023888567923017 -3.90177127926037 9.33819406271226e-05 miRanda -0.299588124426935 0.00920372465137889 NA NA NA hsa-miR-651-5p HGF 2.63593644285064 2.87092871839488e-05 -3.90177127926037 9.33819406271226e-05 MirTarget -0.267594273381361 0.00293543373205292 NA NA NA hsa-miR-944 HGF 7.20925181386398 0.000823207457340648 -3.90177127926037 9.33819406271226e-05 mirMAP -0.118743424839016 0.00026536217515452 NA NA NA hsa-miR-28-5p HIF1A -0.815636722979196 0.0221199948901761 0.731047463819583 0.16939938417342 miRanda -0.252846718732826 0.00322964321035346 NA NA NA hsa-let-7a-5p HMGA2 0.148081801547773 0.645305441523746 2.92920519188411 0.111246834594589 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -1.41622765480738 1.83270984234086e-05 20949044;18413822;23073586;21598109;24612219;23134218;23700794;21412931 Since let-7 miRNAs generally play a tumor-suppressive role as targeting oncogenes such as RAS and HMGA2 our results suggest that AZ-P7a cells release let-7 miRNAs via exosomes into the extracellular environment to maintain their oncogenesis;Recent studies report that HMGA2 is negatively regulated by the let-7 microRNA miRNA family; However no studies have examined the clinical significance of HMGA2 and its relationship to the let-7 miRNA family in gastric cancer; We also did an association study comparing HMGA2 expression and let-7 miRNA family expression in gastric cancer; An inverse correlation between HMGA2 and let-7a was found in gastric cancer cell lines P = 0.08; Furthermore our findings suggest that HMGA2 is negatively regulated by the let-7 miRNA family in human gastric cancer;HMGA2 mRNA and let-7 family microRNA were detected by real time fluorescent quantitative reverse transcription polymerase chain reaction in the corresponding frozen tissues; All let-7 family members were detectable in all ovarian cancer samples and their expression were inversely correlated with HMGA2 mRNA expression r=-0.305P<0.05; The downregulation of let-7 is but not the only mechanism of HMGA2 overexpression in serous ovarian cancer;Role of microRNA let 7 and effect to HMGA2 in esophageal squamous cell carcinoma; To investigated the role of microRNA miRNA let-7 and its regulation on high mobility group A2 HMGA2 protein expression in esophageal squamous cell carcinoma ESCC; To evaluate the role of let-7 and HMGA2 cell proliferations were analyzed with synthetic let-7 mimics- or its inhibitor-transfected cells; The transcription of let-7 inversely correlated with HMGA2 protein; The present results demonstrated that let-7 and HMGA2 involved in ESCC carcinogenesis;HMGA2 is down regulated by microRNA let 7 and associated with epithelial mesenchymal transition in oesophageal squamous cell carcinomas of Kazakhs; To investigate the expression of let-7 and its regulation of high-mobility group A2 protein HMGA2 and to verify the relationship between let-7 HMGA2 and the process of epithelial-mesenchymal transition EMT in oesophageal squamous cell carcinomas OSCC of Kazakh patients; Let-7 could repress expression of HMGA2 after co-transfection with let-7 and HMGA2 P = 0.002; Moreover let-7 expression was observed less frequently P = 2.0 × 10-8 and HMGA2 expression more frequently P = 1.0 × 10-10 in OSCC than in normal adjacent tissues; and let-7 expression was observed less frequently in OSCC from Kazakh patients than in those from Han and Uygur patients P = 0.041; There was a reverse correlation between expression of let-7 and HMGA2 P = 0.018; Expression of let-7 can suppress cell proliferation by acting directly on regulation of HMGA2 in OSCC;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells;Let 7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data; The aim of our study was first to assess the role of HMGA2 expression in the pathogenesis of adipocytic tumors AT and second to seek a potential correlation between overexpression of HMGA2 and let-7 expression inhibition by analyzing a series of 56 benign and malignant AT with molecular cytogenetic data; We measured the levels of expression of HMGA2 mRNA and of eight members of the let-7 microRNA family using quantitative RT-PCR and expression of HMGA2 protein using immunohistochemistry; Although overexpression of both HMGA2 mRNA and protein in a majority of ordinary lipomas without HMGA2 structural rearrangement may have suggested a potential role for let-7 microRNAs we did not observe a significant link with let-7 inhibition in such cases ;;;tumorigenesis;;;;malignant trasformation gastric cancer;gastric cancer;ovarian cancer;esophageal cancer;esophageal cancer;lung squamous cell cancer;lung cancer;sarcoma hsa-let-7b-3p HMGA2 0.589364128513318 0.200507534602851 2.92920519188411 0.111246834594589 mirMAP -0.697735131014097 0.00227414554511165 20949044;18413822;23073586;21598109;24612219;23700794;21412931 Since let-7 miRNAs generally play a tumor-suppressive role as targeting oncogenes such as RAS and HMGA2 our results suggest that AZ-P7a cells release let-7 miRNAs via exosomes into the extracellular environment to maintain their oncogenesis;Recent studies report that HMGA2 is negatively regulated by the let-7 microRNA miRNA family; However no studies have examined the clinical significance of HMGA2 and its relationship to the let-7 miRNA family in gastric cancer; We also did an association study comparing HMGA2 expression and let-7 miRNA family expression in gastric cancer; Furthermore our findings suggest that HMGA2 is negatively regulated by the let-7 miRNA family in human gastric cancer;HMGA2 mRNA and let-7 family microRNA were detected by real time fluorescent quantitative reverse transcription polymerase chain reaction in the corresponding frozen tissues; All let-7 family members were detectable in all ovarian cancer samples and their expression were inversely correlated with HMGA2 mRNA expression r=-0.305P<0.05; The downregulation of let-7 is but not the only mechanism of HMGA2 overexpression in serous ovarian cancer;Role of microRNA let 7 and effect to HMGA2 in esophageal squamous cell carcinoma; To investigated the role of microRNA miRNA let-7 and its regulation on high mobility group A2 HMGA2 protein expression in esophageal squamous cell carcinoma ESCC; To evaluate the role of let-7 and HMGA2 cell proliferations were analyzed with synthetic let-7 mimics- or its inhibitor-transfected cells; The transcription of let-7 inversely correlated with HMGA2 protein; The present results demonstrated that let-7 and HMGA2 involved in ESCC carcinogenesis;HMGA2 is down regulated by microRNA let 7 and associated with epithelial mesenchymal transition in oesophageal squamous cell carcinomas of Kazakhs; To investigate the expression of let-7 and its regulation of high-mobility group A2 protein HMGA2 and to verify the relationship between let-7 HMGA2 and the process of epithelial-mesenchymal transition EMT in oesophageal squamous cell carcinomas OSCC of Kazakh patients; Let-7 could repress expression of HMGA2 after co-transfection with let-7 and HMGA2 P = 0.002; Moreover let-7 expression was observed less frequently P = 2.0 × 10-8 and HMGA2 expression more frequently P = 1.0 × 10-10 in OSCC than in normal adjacent tissues; and let-7 expression was observed less frequently in OSCC from Kazakh patients than in those from Han and Uygur patients P = 0.041; There was a reverse correlation between expression of let-7 and HMGA2 P = 0.018; Expression of let-7 can suppress cell proliferation by acting directly on regulation of HMGA2 in OSCC;MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells;Let 7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data; The aim of our study was first to assess the role of HMGA2 expression in the pathogenesis of adipocytic tumors AT and second to seek a potential correlation between overexpression of HMGA2 and let-7 expression inhibition by analyzing a series of 56 benign and malignant AT with molecular cytogenetic data; We measured the levels of expression of HMGA2 mRNA and of eight members of the let-7 microRNA family using quantitative RT-PCR and expression of HMGA2 protein using immunohistochemistry; Although overexpression of both HMGA2 mRNA and protein in a majority of ordinary lipomas without HMGA2 structural rearrangement may have suggested a potential role for let-7 microRNAs we did not observe a significant link with let-7 inhibition in such cases ;;;tumorigenesis;;;malignant trasformation gastric cancer;gastric cancer;ovarian cancer;esophageal cancer;esophageal cancer;lung cancer;sarcoma hsa-let-7b-5p HMGA2 -0.189422992330471 0.651878220048983 2.92920519188411 0.111246834594589 miRNAWalker2_validate;miRTarBase;MirTarget -0.958792497057909 0.00013106070387031 20949044;18413822;23073586;21598109;24612219;23700794;21412931 Since let-7 miRNAs generally play a tumor-suppressive role as targeting oncogenes such as RAS and HMGA2 our results suggest that AZ-P7a cells release let-7 miRNAs via exosomes into the extracellular environment to maintain their oncogenesis;Recent studies report that HMGA2 is negatively regulated by the let-7 microRNA miRNA family; However no studies have examined the clinical significance of HMGA2 and its relationship to the let-7 miRNA family in gastric cancer; We also did an association study comparing HMGA2 expression and let-7 miRNA family expression in gastric cancer; Furthermore our findings suggest that HMGA2 is negatively regulated by the let-7 miRNA family in human gastric cancer;HMGA2 mRNA and let-7 family microRNA were detected by real time fluorescent quantitative reverse transcription polymerase chain reaction in the corresponding frozen tissues; All let-7 family members were detectable in all ovarian cancer samples and their expression were inversely correlated with HMGA2 mRNA expression r=-0.305P<0.05; The downregulation of let-7 is but not the only mechanism of HMGA2 overexpression in serous ovarian cancer;Role of microRNA let 7 and effect to HMGA2 in esophageal squamous cell carcinoma; To investigated the role of microRNA miRNA let-7 and its regulation on high mobility group A2 HMGA2 protein expression in esophageal squamous cell carcinoma ESCC; To evaluate the role of let-7 and HMGA2 cell proliferations were analyzed with synthetic let-7 mimics- or its inhibitor-transfected cells; The transcription of let-7 inversely correlated with HMGA2 protein; The present results demonstrated that let-7 and HMGA2 involved in ESCC carcinogenesis;HMGA2 is down regulated by microRNA let 7 and associated with epithelial mesenchymal transition in oesophageal squamous cell carcinomas of Kazakhs; To investigate the expression of let-7 and its regulation of high-mobility group A2 protein HMGA2 and to verify the relationship between let-7 HMGA2 and the process of epithelial-mesenchymal transition EMT in oesophageal squamous cell carcinomas OSCC of Kazakh patients; Let-7 could repress expression of HMGA2 after co-transfection with let-7 and HMGA2 P = 0.002; Moreover let-7 expression was observed less frequently P = 2.0 × 10-8 and HMGA2 expression more frequently P = 1.0 × 10-10 in OSCC than in normal adjacent tissues; and let-7 expression was observed less frequently in OSCC from Kazakh patients than in those from Han and Uygur patients P = 0.041; There was a reverse correlation between expression of let-7 and HMGA2 P = 0.018; Expression of let-7 can suppress cell proliferation by acting directly on regulation of HMGA2 in OSCC;MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells;Let 7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data; The aim of our study was first to assess the role of HMGA2 expression in the pathogenesis of adipocytic tumors AT and second to seek a potential correlation between overexpression of HMGA2 and let-7 expression inhibition by analyzing a series of 56 benign and malignant AT with molecular cytogenetic data; We measured the levels of expression of HMGA2 mRNA and of eight members of the let-7 microRNA family using quantitative RT-PCR and expression of HMGA2 protein using immunohistochemistry; Although overexpression of both HMGA2 mRNA and protein in a majority of ordinary lipomas without HMGA2 structural rearrangement may have suggested a potential role for let-7 microRNAs we did not observe a significant link with let-7 inhibition in such cases ;;;tumorigenesis;;;malignant trasformation gastric cancer;gastric cancer;ovarian cancer;esophageal cancer;esophageal cancer;lung cancer;sarcoma hsa-let-7c-5p HMGA2 -2.03831836681378 0.0228401148731997 2.92920519188411 0.111246834594589 miRNAWalker2_validate;miRTarBase;MirTarget -0.466089711085583 5.24474415264744e-05 NA NA NA hsa-miR-125b-2-3p HMGA2 -1.75609980210443 0.122616157214143 2.92920519188411 0.111246834594589 mirMAP -0.352853678809057 0.000106361419142526 NA NA NA hsa-miR-142-3p HMGA2 4.35304505457969 3.10014573651358e-10 2.92920519188411 0.111246834594589 PITA;miRanda;miRNATAP -0.437125863582589 0.00283234290280192 NA NA NA hsa-miR-195-3p HMGA2 -2.39100534119332 0.000185405399054065 2.92920519188411 0.111246834594589 mirMAP -0.457872367681466 0.00496166781373377 NA NA NA hsa-miR-23b-3p HMGA2 -0.581135273821923 0.190478897170459 2.92920519188411 0.111246834594589 mirMAP -0.672781716128392 0.00463838672519931 NA NA NA hsa-miR-29b-2-5p HMGA2 -0.596051745078872 0.189540844841389 2.92920519188411 0.111246834594589 mirMAP -0.64332971955481 0.00556853317890807 NA NA NA hsa-miR-30e-5p HMGA2 0.780047227271616 0.0346714425913016 2.92920519188411 0.111246834594589 mirMAP -1.20333981862507 2.39011774342209e-05 NA NA NA hsa-miR-342-3p HMGA2 1.31107714473009 0.0207211910724662 2.92920519188411 0.111246834594589 miRanda -0.524964070269732 0.00440654995224808 NA NA NA hsa-miR-193b-3p LEF1 1.35015762547152 0.0874921379319504 -1.06801208642423 0.21098542163647 miRNAWalker2_validate -0.349322384823671 5.36528724241979e-09 NA NA NA hsa-miR-330-5p LEF1 2.25110496739954 0.000275527655397415 -1.06801208642423 0.21098542163647 miRanda -0.403439067915215 1.29300750911004e-07 NA NA NA hsa-miR-148b-5p LIMS1 2.80812018666078 3.97536665756679e-08 0.324963887780457 0.637499158364339 MirTarget -0.201736143808551 0.00731686679940044 NA NA NA hsa-miR-192-5p LIMS1 1.77716187978541 0.113485496183047 0.324963887780457 0.637499158364339 miRNAWalker2_validate;MirTarget -0.107535803739372 0.00186505748428585 NA NA NA hsa-miR-215-5p LIMS1 3.66990923176752 0.00294614570694381 0.324963887780457 0.637499158364339 miRNAWalker2_validate;MirTarget -0.105991244659721 0.000702277407347265 NA NA NA hsa-miR-29b-3p LIMS1 0.666547117072858 0.234055379278093 0.324963887780457 0.637499158364339 MirTarget;miRNATAP -0.209880098845281 0.00268684228244032 NA NA NA hsa-miR-29c-3p LIMS1 -0.414153610337085 0.529344128062017 0.324963887780457 0.637499158364339 MirTarget;miRNATAP -0.221057937525627 0.000185101642238824 NA NA NA hsa-miR-30b-5p LIMS1 0.0238659735605804 0.953223658270319 0.324963887780457 0.637499158364339 MirTarget -0.301051593654994 0.00196087990194845 NA NA NA hsa-miR-30c-5p LIMS1 0.38723991118075 0.348605235643473 0.324963887780457 0.637499158364339 MirTarget -0.247830537983224 0.00972461890692938 NA NA NA hsa-miR-30e-5p LIMS1 0.780047227271616 0.0346714425913016 0.324963887780457 0.637499158364339 MirTarget -0.42353695091713 7.14125678814287e-05 NA NA NA hsa-miR-3607-3p LIMS1 1.38015131722213 0.0240067155694847 0.324963887780457 0.637499158364339 mirMAP -0.242302537118024 0.000134742632109103 NA NA NA hsa-miR-590-3p LIMS1 2.35429565068338 2.79601879608564e-06 0.324963887780457 0.637499158364339 miRNAWalker2_validate;miRanda -0.212216807715907 0.00580703622894193 NA NA NA hsa-let-7a-5p LOXL3 0.148081801547773 0.645305441523746 -1.46523594349725 0.00299540480120979 miRNATAP -0.241259913939134 0.00718216324149377 NA NA NA hsa-let-7b-5p LOXL3 -0.189422992330471 0.651878220048983 -1.46523594349725 0.00299540480120979 miRNATAP -0.221516508712226 0.00106180218642835 NA NA NA hsa-miR-101-3p NOG -1.12421603598195 0.0200907284788457 -1.21608867705426 0.353623614382544 miRNATAP -0.588806463252439 0.000125537379245868 NA NA NA hsa-miR-142-5p NOG 3.95552531913424 1.49536283724079e-08 -1.21608867705426 0.353623614382544 miRNATAP -0.522147752334842 3.37362248010374e-07 NA NA NA hsa-miR-129-5p NOTCH1 -2.66843722411409 0.00695783358331245 0.769690137962651 0.220066774948586 miRNAWalker2_validate -0.110371326084891 0.00232253449431888 NA NA NA hsa-miR-200b-3p NOTCH1 5.56167217794639 6.43540045061709e-16 0.769690137962651 0.220066774948586 MirTarget;TargetScan -0.128510800873159 0.00896650356017729 26012256;23430952 Nobiletin inhibited hypoxia induced epithelial mesenchymal transition of lung cancer cells by inactivating of Notch 1 signaling and switching on miR 200b; Our findings suggest that downregulation of Notch-1 and reexpression of miR-200b by nobiletin might be a novel remedy for the therapy of lung cancer;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis ; lung cancer;sarcoma hsa-miR-28-5p NOTCH1 -0.815636722979196 0.0221199948901761 0.769690137962651 0.220066774948586 miRanda -0.296325329918512 0.00345365385087571 NA NA NA hsa-miR-30a-5p NOTCH1 -0.768430903969183 0.320487552854215 0.769690137962651 0.220066774948586 miRNAWalker2_validate;miRTarBase;miRNATAP -0.204280293555659 7.12369623434561e-06 NA NA NA hsa-miR-326 NOTCH1 1.76645822596029 0.0367310428720192 0.769690137962651 0.220066774948586 miRNAWalker2_validate;miRTarBase -0.125554557582319 0.00291896959861709 NA NA NA hsa-miR-34a-5p NOTCH1 0.830377770217786 0.0477544831885907 0.769690137962651 0.220066774948586 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.232172466836467 0.00672573934974206 20351093;22438124;23140286;24349627;24565525;25783790;27082152;23642368;22347519;23430952;23902763;21743299;22992310;23145211;25623761;23085450 MicroRNA 34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells; Computational miRNA target prediction suggested that Notch1 and Jagged1 were targets of miR-34a; By using functional assays miR-34a was demonstrated to bind to the 3' untranslated regions of Notch1 and Jagged1; Forced expression of miR-34a altered the expression of Notch1 and Jagged1 protein as well as Notch signaling as shown by the response of Hairy Enhancer of Split-1 protein to these treatments using western blot analysis;Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells; In our study using miRNA microarray we observed that downregulation of the Notch-1 pathway by delta-tocotrienol correlated with upregulation of miR-34a in nonsmall cell lung cancer cells NSCLC;We found that Re-expression forced expression of miR-34a inhibits cell growth and induces apoptosis with concomitant down-regulation of Notch-1 signaling pathway one of the target of miR-34a; Moreover treatment of PC cells with a natural compound genistein led to the up-regulation of miR-34a resulting in the down-regulation of Notch-1 which was correlated with inhibition of cell growth and induction of apoptosis;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed reexpression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;In addition intracellular restoration of miR-34a inhibited breast cancer cell migration via targeting Notch-1 signaling;MicroRNA 34a suppresses the breast cancer stem cell like characteristics by downregulating Notch1 pathway; In this study we verified that miR-34a directly and functionally targeted Notch1 in MCF-7 cells; We reported that miR-34a negatively regulated cell proliferation migration and invasion and breast cancer stem cell propagation by downregulating Notch1; The expression of miR-34a was negatively correlated with tumor stages metastasis and Notch1 expression in breast cancer tissues; Furthermore overexpression of miR-34a increased chemosensitivity of breast cancer cells to paclitaxel PTX by downregulating the Notch1 pathway; Taken together our results indicate that miR-34a inhibited breast cancer stemness and increased the chemosensitivity to PTX partially by downregulating the Notch1 pathway suggesting that miR-34a/Notch1 play an important role in regulating breast cancer stem cells;We showed that miR-34a as a tumor suppressor could separately reduce the stemness of BCSCs and activate the cytotoxic susceptibility of BCSCs to natural killer NK cells in vitro via down regulating the expression of Notch1 signaling molecules;Mechanistically miR-34a sequesters Notch1 mRNA to generate a sharp threshold response where a bimodal Notch signal specifies the choice between self-renewal and differentiation;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed re-expression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis;Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial mesenchymal transition EMT by miR 34a mediated suppression of Notch 1 expression in non small cell lung cancer cell lines; Indeed rhamnetin and cirsiliol increased the expression of tumor-suppressive microRNA miR-34a in a p53-dependent manner leading to inhibition of Notch-1 expression;MicroRNA 34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme; Also we identified notch1 as a direct target gene of miR-34a; Knockdown of notch1 showed similar cellular functions as overexpression of miR-34a both in vitro and in vivo; Collectively our findings show that miR-34a is downregulated in GBM cells and inhibits GBM growth by targeting notch1;The re-expression of miR-34 led to a marked reduction in the expression of its target gene Notch-1;Inactivation of AR and Notch 1 signaling by miR 34a attenuates prostate cancer aggressiveness; We found that over-expression of miR-34a led to reduced expression of AR PSA and Notch-1; These findings suggest that the loss of miR-34a is directly linked with up-regulation of AR and Notch-1 both of which are highly expressed in PCa and thus finding innovative approaches by which miR-34a expression could be up-regulated will have a huge impact on the treatment of PCa especially for the treatment of mCRPC;miR 34a may regulate sensitivity of breast cancer cells to adriamycin via targeting Notch1; To explore the influence of miR-34a on Notch1 expression in breast cancer cells and to explore the role of miR-34a in the sensitivity of breast cancer cells to Adriamycin ADR; The expression levels of Notch1 mRNA and protein in MCF-7/ADR cells transfected with miR-34a mimics were significantly up-regulated; On the contrary the expressions of Notch1 mRNA and protein in MCF-7 cells transfected with miR-34a inhibitor were down-regulated; miR-34a negatively regulates the expression of Notch1 at both mRNA and protein levels;MicroRNA 34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting Notch1; The association of miR-34a and Notch1 was analyzed by dual-luciferase reporter assay and Notch1-siRNA technology; Real-time PCR assay was performed to test the expression of miR-34a and Notch1 in 38 selective breast cancer tissue samples; MiR-34a mimic could inhibit the luciferase activity of the construct containing wild-type 3' UTR of Notch1 in MCF-7/ADR cells; Further there was an inverse association between Notch1 and miR-34a expression in breast cancer; Dysregulation of miR-34a plays critical roles in the acquired ADR resistance of breast cancer at least in part via targeting Notch1 drug resistance;;;;cell migration;staging;metastasis;;differentiation;drug resistance;;;;;;;;drug resistance cervical and endocervical cancer;lung squamous cell cancer;pancreatic cancer;prostate cancer;breast cancer;breast cancer;breast cancer;colon cancer;prostate cancer;sarcoma;lung squamous cell cancer;glioblastoma;colon cancer;prostate cancer;breast cancer;breast cancer hsa-miR-429 NOTCH1 6.39965293994036 1.96920201593608e-18 0.769690137962651 0.220066774948586 MirTarget;PITA;miRanda;miRNATAP -0.123045513294408 0.00730512228976083 NA NA NA hsa-miR-582-5p NOTCH1 0.685177900016753 0.447761540297692 0.769690137962651 0.220066774948586 PITA;miRNATAP -0.105502291679691 0.0073527830487362 NA NA NA hsa-miR-92b-3p NOTCH1 1.69303761469782 0.0103484911955574 0.769690137962651 0.220066774948586 miRNATAP -0.284108256565684 7.34752569192484e-08 NA NA NA hsa-miR-107 SNAI2 1.49443409571439 0.000130594521065411 -1.63105031719645 0.151947151729511 miRanda -0.697492767535727 2.28747541234486e-05 NA NA NA hsa-miR-148b-3p SNAI2 1.75622244535669 8.84414356040579e-08 -1.63105031719645 0.151947151729511 miRNAWalker2_validate -1.20416541853834 3.64181808017381e-10 NA NA NA hsa-miR-182-5p SNAI2 5.86988712704738 1.22411588571584e-15 -1.63105031719645 0.151947151729511 miRNAWalker2_validate;miRNATAP -0.350535353498724 2.46839505266114e-05 NA NA NA hsa-miR-200b-3p SNAI2 5.56167217794639 6.43540045061709e-16 -1.63105031719645 0.151947151729511 TargetScan -0.649397403907546 3.78497809111695e-14 NA NA NA hsa-miR-200c-3p SNAI2 6.47012025883743 2.64500707716408e-26 -1.63105031719645 0.151947151729511 miRNATAP -0.366231228387546 0.000154734539121361 NA NA NA hsa-miR-375 SNAI2 3.3784490463318 0.0449946294355695 -1.63105031719645 0.151947151729511 miRanda -0.405761563211418 3.15055753376226e-32 NA NA NA hsa-miR-429 SNAI2 6.39965293994036 1.96920201593608e-18 -1.63105031719645 0.151947151729511 PITA;miRanda;miRNATAP -0.555621837620757 5.73431212612017e-12 NA NA NA hsa-miR-532-5p SNAI2 -0.297424983759107 0.503934707453099 -1.63105031719645 0.151947151729511 PITA -0.961387727223608 1.45748468588014e-11 NA NA NA hsa-miR-96-5p SNAI2 5.62521466029286 1.54938806718028e-10 -1.63105031719645 0.151947151729511 miRNATAP -0.459083416473505 8.67842804706358e-08 NA NA NA hsa-miR-342-3p SOX9 1.31107714473009 0.0207211910724662 3.97100906038777 1.64864907596943e-05 miRanda -0.360998147729631 0.000104076096934726 NA NA NA hsa-miR-9-3p SOX9 1.69328215716742 0.125170982657059 3.97100906038777 1.64864907596943e-05 miRNATAP -0.152740146119417 0.00163878199820838 NA NA NA hsa-miR-141-3p TGFB2 7.30474126597325 1.45115996357606e-24 -1.43663821995393 0.208151431685717 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.215624739416799 0.00999464963415708 NA NA NA hsa-miR-142-3p TGFB2 4.35304505457969 3.10014573651358e-10 -1.43663821995393 0.208151431685717 miRNATAP -0.239982637825598 0.00829657759355293 NA NA NA hsa-miR-148b-3p TGFB2 1.75622244535669 8.84414356040579e-08 -1.43663821995393 0.208151431685717 MirTarget -0.652112155639784 0.000929853930431754 NA NA NA hsa-miR-200a-3p TGFB2 6.336081120041 4.024313571871e-16 -1.43663821995393 0.208151431685717 MirTarget;miRNATAP -0.351128170275698 7.00885632360109e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 6.35084246337388 7.89944323347948e-08 -1.43663821995393 0.208151431685717 MirTarget -0.267521839692763 3.62940840958117e-07 NA NA NA hsa-miR-2277-5p TGFB2 3.02139935290539 0.0134629626930938 -1.43663821995393 0.208151431685717 MirTarget -0.249573719882911 0.00777879243940924 NA NA NA hsa-miR-362-5p TGFB2 -1.22309034685697 0.0452665543907975 -1.43663821995393 0.208151431685717 MirTarget -0.314690950040788 0.00297612558507577 NA NA NA hsa-miR-375 TGFB2 3.3784490463318 0.0449946294355695 -1.43663821995393 0.208151431685717 miRNAWalker2_validate -0.113027113272895 0.00302877404950613 NA NA NA hsa-miR-429 TGFB2 6.39965293994036 1.96920201593608e-18 -1.43663821995393 0.208151431685717 miRNATAP -0.317868138018968 0.000128726503171991 NA NA NA hsa-miR-500a-5p TGFB2 0.0170829425378565 0.973960207660626 -1.43663821995393 0.208151431685717 mirMAP -0.329451267369997 0.00832586461531593 NA NA NA hsa-miR-500b-5p TGFB2 0.0167434146432646 0.974498641907253 -1.43663821995393 0.208151431685717 MirTarget -0.327405186316064 0.00868447231417683 NA NA NA hsa-let-7b-5p TGFBR1 -0.189422992330471 0.651878220048983 -0.505713612135208 0.324744061078335 miRNATAP -0.242601587479934 0.000517890990887836 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC; In luciferase assays the risk-associated allele for rs868 was associated with half the luciferase expression in the presence of miRNA let-7b-5p compared with protective allele suggesting more binding of let-7b-5p and less TGFBR1 expression colorectal cancer hsa-let-7c-5p TGFBR1 -2.03831836681378 0.0228401148731997 -0.505713612135208 0.324744061078335 miRNAWalker2_validate;miRTarBase -0.141642653096274 9.4282969596595e-06 NA NA NA hsa-let-7g-5p TGFBR1 0.857251702023746 0.00647597344297273 -0.505713612135208 0.324744061078335 miRNATAP -0.267873123242374 0.00450205280436413 NA NA NA hsa-miR-101-3p TGFBR1 -1.12421603598195 0.0200907284788457 -0.505713612135208 0.324744061078335 miRNAWalker2_validate;miRNATAP -0.25766117737473 1.65614003073399e-05 NA NA NA hsa-miR-101-5p TGFBR1 -1.41522721523565 0.0166784131265028 -0.505713612135208 0.324744061078335 mirMAP -0.147066901987004 0.00277627040116552 NA NA NA hsa-miR-128-3p TGFBR1 1.36248409467631 0.00408435995818078 -0.505713612135208 0.324744061078335 miRNAWalker2_validate;miRTarBase -0.218506283449698 0.000352839376558225 NA NA NA hsa-miR-200b-3p TGFBR1 5.56167217794639 6.43540045061709e-16 -0.505713612135208 0.324744061078335 mirMAP -0.254716587127543 6.86106889972148e-11 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-3065-5p TGFBR1 2.14185373842821 0.0609400502269891 -0.505713612135208 0.324744061078335 mirMAP -0.111612566907259 0.000387470900601915 NA NA NA hsa-miR-361-5p TGFBR1 0.00649167180664723 0.985202350239079 -0.505713612135208 0.324744061078335 miRanda;mirMAP;miRNATAP -0.236124496506177 0.00538272648027843 NA NA NA hsa-miR-374a-5p TGFBR1 0.278549982012055 0.45888283715888 -0.505713612135208 0.324744061078335 mirMAP -0.235099661936825 0.0027662227971746 NA NA NA hsa-miR-429 TGFBR1 6.39965293994036 1.96920201593608e-18 -0.505713612135208 0.324744061078335 miRanda;miRNATAP -0.219958031472476 1.89353165194703e-09 NA NA NA hsa-miR-452-5p TGFBR1 2.45466810475361 0.00114794259949532 -0.505713612135208 0.324744061078335 mirMAP -0.12029641667783 0.00160222545222133 NA NA NA hsa-miR-15a-5p TGFBR3 2.0535411006904 1.91108976398046e-06 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.398252051497784 0.000579622324303971 NA NA NA hsa-miR-15b-5p TGFBR3 3.32329949959268 8.40210501034588e-13 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.308598579670601 0.00329766225446434 NA NA NA hsa-miR-16-2-3p TGFBR3 3.79845098071094 1.49120139344659e-13 -4.8172798831592 2.83698243439907e-08 mirMAP -0.510816849440913 3.63317831108554e-08 NA NA NA hsa-miR-16-5p TGFBR3 2.93575808220754 2.15436817162977e-10 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.398826844441648 0.000167618497525506 NA NA NA hsa-miR-18a-3p TGFBR3 3.64944956993027 7.20156641833731e-07 -4.8172798831592 2.83698243439907e-08 MirTarget -0.276229137548183 3.81281614466793e-05 NA NA NA hsa-miR-18a-5p TGFBR3 3.90770175770219 9.15298615034137e-10 -4.8172798831592 2.83698243439907e-08 MirTarget -0.313514148171929 3.94123087172394e-05 NA NA NA hsa-miR-21-5p TGFBR3 2.65163477806992 6.72089787690756e-16 -4.8172798831592 2.83698243439907e-08 miRNAWalker2_validate -0.67212333147917 5.19481182016835e-06 NA NA NA hsa-miR-222-5p TGFBR3 2.52056758362407 0.00142010793166944 -4.8172798831592 2.83698243439907e-08 MirTarget -0.352823463780761 1.35483244347225e-08 NA NA NA hsa-miR-27a-3p TGFBR3 1.76094007417453 0.000216137556256765 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.352585790116035 0.000816843585172177 NA NA NA hsa-miR-27b-3p TGFBR3 -0.0929089601968123 0.85847352206581 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.287369611968484 0.00313932913796485 NA NA NA hsa-miR-33a-3p TGFBR3 2.06269680799532 0.00156436055383943 -4.8172798831592 2.83698243439907e-08 mirMAP -0.24065182722194 0.00179364317738789 NA NA NA hsa-miR-484 TGFBR3 1.79050445056016 0.000217287101253701 -4.8172798831592 2.83698243439907e-08 MirTarget;miRNATAP -0.315397888660127 0.00235031958258578 NA NA NA hsa-miR-590-3p TGFBR3 2.35429565068338 2.79601879608564e-06 -4.8172798831592 2.83698243439907e-08 MirTarget;miRanda;mirMAP -0.285337459789671 0.00402891046812002 NA NA NA hsa-miR-627-5p TGFBR3 1.68461263902065 0.00697075274507733 -4.8172798831592 2.83698243439907e-08 MirTarget -0.254442023518234 0.0016844231918282 NA NA NA hsa-miR-944 TGFBR3 7.20925181386398 0.000823207457340648 -4.8172798831592 2.83698243439907e-08 mirMAP -0.130912091086309 4.23191284323791e-06 NA NA NA hsa-miR-590-3p WNT11 2.35429565068338 2.79601879608564e-06 -1.12002304030541 0.399603501707316 miRanda -0.529097966959972 0.000347687911762461 NA NA NA hsa-miR-107 WNT4 1.49443409571439 0.000130594521065411 0.346156151965651 0.759005168873886 PITA;miRNATAP -0.706595074754511 1.43378256348642e-05 NA NA NA hsa-miR-141-3p WNT5A 7.30474126597325 1.45115996357606e-24 -0.335254267155151 0.714960765245992 TargetScan -0.185678372077036 0.00570301174175726 NA NA NA hsa-miR-15b-3p WNT5A 3.57530146629867 5.89922785773482e-11 -0.335254267155151 0.714960765245992 mirMAP -0.24311589972858 0.00863820879774156 NA NA NA hsa-miR-16-2-3p WNT5A 3.79845098071094 1.49120139344659e-13 -0.335254267155151 0.714960765245992 MirTarget;mirMAP -0.311764225567874 0.00135279684345927 NA NA NA hsa-miR-16-5p WNT5A 2.93575808220754 2.15436817162977e-10 -0.335254267155151 0.714960765245992 miRNAWalker2_validate -0.290441753916783 0.00829455186858816 NA NA NA hsa-miR-2110 WNT5A 1.8070969695103 0.00137196847440523 -0.335254267155151 0.714960765245992 MirTarget -0.30255767867938 0.00122728628679992 NA NA NA hsa-miR-30c-5p WNT5A 0.38723991118075 0.348605235643473 -0.335254267155151 0.714960765245992 mirMAP -0.369350346658232 0.00376556464462393 NA NA NA hsa-miR-30d-3p WNT5A -0.0740421896025512 0.857423650167556 -0.335254267155151 0.714960765245992 mirMAP -0.440328526023165 0.000555223243909098 NA NA NA hsa-miR-30d-5p WNT5A 0.302504510257496 0.380193536606962 -0.335254267155151 0.714960765245992 mirMAP -0.416582436731857 0.00691722632235903 NA NA NA hsa-miR-30e-5p WNT5A 0.780047227271616 0.0346714425913016 -0.335254267155151 0.714960765245992 mirMAP -0.392965061384389 0.00598951520393619 NA NA NA hsa-miR-330-5p WNT5A 2.25110496739954 0.000275527655397415 -0.335254267155151 0.714960765245992 miRanda -0.317182601686914 0.00013146381356929 NA NA NA hsa-miR-582-5p WNT5A 0.685177900016753 0.447761540297692 -0.335254267155151 0.714960765245992 miRNATAP -0.175734719122522 0.00222477334080145 NA NA NA hsa-miR-616-5p WNT5A 2.48416313933027 0.00318247475868827 -0.335254267155151 0.714960765245992 mirMAP -0.276707442691596 0.000306684343847227 NA NA NA hsa-miR-92a-3p WNT5A 1.87892405805529 1.27013821556583e-05 -0.335254267155151 0.714960765245992 miRNAWalker2_validate -0.492024474546178 3.85220646721685e-05 NA NA NA