miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-148a-3p A4GNT -0.748702855596996 3.93313343865641e-07 -1.23788904255124 0.00041788399420954 MirTarget -0.727930454392835 1.19337356882915e-10 NA NA NA hsa-miR-148a-5p ABCB5 -0.767626696027761 1.08359477494797e-06 1.74028493510799 1.47575557539883e-05 mirMAP -0.574874959132385 3.12158779812702e-06 NA NA NA hsa-miR-148a-5p ABCC5 -0.767626696027761 1.08359477494797e-06 1.23282495059029 1.29865153692267e-30 mirMAP -0.205149749314302 3.64559577102729e-09 NA NA NA hsa-miR-148a-5p ABI2 -0.767626696027761 1.08359477494797e-06 0.140168313926931 0.173394233347582 miRNATAP -0.243936006449405 1.03837970166959e-15 NA NA NA hsa-miR-148a-3p ACHE -0.748702855596996 3.93313343865641e-07 0.0664775463470139 0.84521711408755 miRNATAP -0.644498628240824 3.7505390632337e-09 NA NA NA hsa-miR-148a-3p ACSL4 -0.748702855596996 3.93313343865641e-07 2.07128895001209 1.06074462060898e-08 miRNATAP -0.646374144431349 5.43959417232703e-08 NA NA NA hsa-miR-148a-5p ACTG1 -0.767626696027761 1.08359477494797e-06 -0.122794075175761 0.20937956377109 MirTarget;miRNATAP -0.165356696033631 1.94023291301734e-08 NA NA NA hsa-miR-148a-5p ACTR3 -0.767626696027761 1.08359477494797e-06 0.0510136297649586 0.43435255813018 mirMAP -0.118205355491735 1.26305541341443e-09 NA NA NA hsa-miR-148a-3p ACVR1 -0.748702855596996 3.93313343865641e-07 -0.436041316598948 1.42037811134341e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.127757812095218 0.000102607735840908 NA NA NA hsa-miR-148a-3p ADAM10 -0.748702855596996 3.93313343865641e-07 -0.00403457779534389 0.978295883029657 MirTarget -0.110219431820108 0.02275270707882 NA NA NA hsa-miR-148a-3p ADAM19 -0.748702855596996 3.93313343865641e-07 -0.32160702928448 0.0232139582513919 mirMAP -0.325649695504387 5.14611973715324e-13 NA NA NA hsa-miR-148a-3p ADAM22 -0.748702855596996 3.93313343865641e-07 1.16776109376783 0.000384818007613429 MirTarget;miRNATAP -0.570717351275375 9.08076638454519e-08 NA NA NA hsa-miR-148a-3p ADAM23 -0.748702855596996 3.93313343865641e-07 1.53172738337562 0.000126500167051167 MirTarget -0.471790043846003 0.000320728545434591 NA NA NA hsa-miR-148a-3p ADAMTS15 -0.748702855596996 3.93313343865641e-07 -0.880416409258241 0.00205636793456789 MirTarget;miRNATAP -0.407109521853394 1.22320303172348e-05 NA NA NA hsa-miR-148a-5p ADAMTS15 -0.767626696027761 1.08359477494797e-06 -0.880416409258241 0.00205636793456789 mirMAP -0.395833687232202 5.69496965035486e-06 NA NA NA hsa-miR-148a-3p ADAMTS18 -0.748702855596996 3.93313343865641e-07 1.43554458022524 5.55511372449862e-06 miRNATAP -0.208100007448669 0.0466744182094337 NA NA NA hsa-miR-148a-3p ADAMTS5 -0.748702855596996 3.93313343865641e-07 -0.158955986983549 0.364991157590809 miRNATAP -0.306850769456875 5.57468547782841e-08 NA NA NA hsa-miR-148a-5p ADAMTS5 -0.767626696027761 1.08359477494797e-06 -0.158955986983549 0.364991157590809 mirMAP;miRNATAP -0.308533861859732 5.26003304302314e-09 NA NA NA hsa-miR-148a-3p ADM2 -0.748702855596996 3.93313343865641e-07 1.7229047600607 3.16835442282685e-11 mirMAP -0.426317474351994 7.21843489038708e-07 NA NA NA hsa-miR-148a-3p ADPRH -0.748702855596996 3.93313343865641e-07 -0.127900064307657 0.267398619612325 MirTarget -0.246854409712485 1.81775560789359e-11 NA NA NA hsa-miR-148a-5p ADSS -0.767626696027761 1.08359477494797e-06 0.308300366809032 0.000331329135728686 MirTarget -0.107719054317478 3.98660436059003e-05 NA NA NA hsa-miR-148a-5p AGPAT4 -0.767626696027761 1.08359477494797e-06 0.868498368821504 6.97076886009297e-05 mirMAP -0.25358617166197 0.000159739432980232 NA NA NA hsa-miR-148a-3p AHDC1 -0.748702855596996 3.93313343865641e-07 -0.233452674379399 0.0262629700720901 miRNATAP -0.118432059847956 0.000531083692723168 NA NA NA hsa-miR-148a-5p ALPK3 -0.767626696027761 1.08359477494797e-06 1.31950289656162 7.07896178270265e-07 mirMAP -0.304189790935749 0.000219680744059371 NA NA NA hsa-miR-148a-3p AMZ1 -0.748702855596996 3.93313343865641e-07 -1.27523518848137 0.00014004218753246 mirMAP -0.439309250759227 6.17486486218864e-05 NA NA NA hsa-miR-148a-3p ANK2 -0.748702855596996 3.93313343865641e-07 -0.936784357118896 8.39839404737194e-05 MirTarget;miRNATAP -0.442851290420514 9.87487353462611e-09 NA NA NA hsa-miR-148a-5p ANK2 -0.767626696027761 1.08359477494797e-06 -0.936784357118896 8.39839404737194e-05 MirTarget;miRNATAP -0.299395953935553 4.26418227071263e-05 NA NA NA hsa-miR-148a-3p ANKRD27 -0.748702855596996 3.93313343865641e-07 0.900670804616695 4.42329061698872e-15 mirMAP -0.177436391740684 3.94392699827362e-06 NA NA NA hsa-miR-148a-3p ANKRD52 -0.748702855596996 3.93313343865641e-07 1.45719998646575 1.747377108051e-36 mirMAP;miRNATAP -0.254983576295231 2.94153541356069e-10 NA NA NA hsa-miR-148a-5p ANKRD52 -0.767626696027761 1.08359477494797e-06 1.45719998646575 1.747377108051e-36 miRNATAP -0.20113812107064 1.4236807347792e-07 NA NA NA hsa-miR-148a-3p ANKS6 -0.748702855596996 3.93313343865641e-07 0.759243866236994 0.0152104928778901 mirMAP -0.627092112569914 4.43139828118081e-10 NA NA NA hsa-miR-148a-3p ANXA4 -0.748702855596996 3.93313343865641e-07 -0.204045790335896 0.167003285162076 MirTarget -0.35947112824918 1.42075019192064e-14 NA NA NA hsa-miR-106b-5p APC 0.648901865047099 8.24870862047885e-09 -0.178106776451097 0.0679159506996304 miRNAWalker2_validate;miRTarBase -0.152406181389829 0.000242059519728295 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-21-5p APC 1.51084295924322 1.54551622173259e-34 -0.178106776451097 0.0679159506996304 miRNAWalker2_validate -0.170963654395431 1.15664392926358e-06 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-148a-3p ARAP2 -0.748702855596996 3.93313343865641e-07 -1.13466869294013 1.21001797842144e-11 MirTarget -0.263514528901823 2.11834622572004e-06 NA NA NA hsa-miR-148a-5p ARHGAP31 -0.767626696027761 1.08359477494797e-06 -0.423826059922046 0.00347168991806229 mirMAP -0.143131668733732 0.0012893212283231 NA NA NA hsa-miR-103a-3p ARHGAP5 0.765568928457606 3.05497476509383e-12 -0.390501975399923 8.01729872271933e-05 MirTarget -0.190378797120845 9.62393438802819e-06 NA NA NA hsa-miR-155-5p ARHGAP5 0.0108524225071784 0.95651331033505 -0.390501975399923 8.01729872271933e-05 mirMAP -0.106689067532435 1.07117354005012e-05 NA NA NA hsa-miR-15a-5p ARHGAP5 0.349521211668244 0.000770735998804736 -0.390501975399923 8.01729872271933e-05 MirTarget;miRNATAP -0.140114967228855 0.00276448285918912 NA NA NA hsa-miR-16-1-3p ARHGAP5 0.392360028038559 0.00112481918108198 -0.390501975399923 8.01729872271933e-05 MirTarget -0.10655854170515 0.00823158833704956 NA NA NA hsa-miR-17-5p ARHGAP5 0.698861147045461 2.43854106455398e-05 -0.390501975399923 8.01729872271933e-05 miRNAWalker2_validate -0.168233712468027 4.06938935137717e-09 NA NA NA hsa-miR-181a-5p ARHGAP5 0.250113435902954 0.0551933249319293 -0.390501975399923 8.01729872271933e-05 mirMAP -0.178285338979484 1.42745874554536e-06 NA NA NA hsa-miR-181b-5p ARHGAP5 0.488256489401108 0.00105321129419701 -0.390501975399923 8.01729872271933e-05 mirMAP -0.156486821983914 1.13906378427161e-06 NA NA NA hsa-miR-18a-5p ARHGAP5 0.918028187958706 1.90229510425322e-05 -0.390501975399923 8.01729872271933e-05 MirTarget -0.139657415536736 1.92972267421708e-10 NA NA NA hsa-miR-19a-3p ARHGAP5 1.01712596153672 2.57753201450625e-07 -0.390501975399923 8.01729872271933e-05 miRNATAP -0.102176278799659 2.18507337800794e-05 NA NA NA hsa-miR-19b-3p ARHGAP5 0.601279551368824 0.00016685097085251 -0.390501975399923 8.01729872271933e-05 miRNATAP -0.126249258755046 2.62351845075989e-05 NA NA NA hsa-miR-421 ARHGAP5 0.941856334694081 6.12167297054077e-08 -0.390501975399923 8.01729872271933e-05 PITA;miRanda;mirMAP;miRNATAP -0.100369042715833 0.000260906838220345 NA NA NA hsa-miR-500a-5p ARHGAP5 0.797906382969156 9.15958171084226e-08 -0.390501975399923 8.01729872271933e-05 mirMAP -0.130200028078366 4.44416835178627e-05 NA NA NA hsa-miR-501-5p ARHGAP5 1.15231083477882 2.98906150004088e-10 -0.390501975399923 8.01729872271933e-05 PITA;mirMAP -0.135613237661836 1.27605396391392e-07 NA NA NA hsa-miR-590-5p ARHGAP5 -0.103355559980404 0.310027295317092 -0.390501975399923 8.01729872271933e-05 miRanda -0.125900328591526 0.00896894861120512 NA NA NA hsa-miR-148a-3p ARHGEF17 -0.748702855596996 3.93313343865641e-07 0.063804626387558 0.699136901516712 miRNATAP -0.457419364506958 7.79553515305781e-19 NA NA NA hsa-miR-148a-5p ARHGEF18 -0.767626696027761 1.08359477494797e-06 0.502672652160577 7.857826027444e-09 MirTarget;miRNATAP -0.122633724383797 4.95833408302421e-06 NA NA NA hsa-miR-148a-5p ARID5B -0.767626696027761 1.08359477494797e-06 -0.51790455974164 0.000116493206015505 mirMAP -0.172074741936606 2.94141771373089e-05 NA NA NA hsa-miR-148a-5p ASAH1 -0.767626696027761 1.08359477494797e-06 -0.437083778793473 0.000562653662540471 MirTarget;miRNATAP -0.216670978507214 1.71574654048814e-08 NA NA NA hsa-miR-148a-3p ATG4D -0.748702855596996 3.93313343865641e-07 0.238017440609291 0.0358760810215454 MirTarget -0.177564676097827 1.28064680165471e-06 NA NA NA hsa-miR-148a-3p ATP11A -0.748702855596996 3.93313343865641e-07 0.189226775577938 0.159981440120013 MirTarget -0.168910484576989 0.000112028647058078 NA NA NA hsa-miR-148a-3p ATP2B4 -0.748702855596996 3.93313343865641e-07 0.270147249141007 0.0673602510700001 MirTarget;miRNATAP -0.111342871164415 0.0211096551467596 NA NA NA hsa-miR-148a-3p ATP7A -0.748702855596996 3.93313343865641e-07 0.251321858484382 0.0188455783467549 MirTarget;miRNATAP -0.117619391345964 0.000738334866649139 NA NA NA hsa-miR-148a-3p AURKB -0.748702855596996 3.93313343865641e-07 3.49342722879335 6.3137526890155e-40 miRNAWalker2_validate -0.529634555771283 1.73415568417495e-08 NA NA NA hsa-let-7b-3p AXIN2 -1.21979213547786 5.84575581584603e-17 0.113841868770703 0.752977397700815 miRNATAP -0.270257334726793 0.0204955473660487 NA NA NA hsa-let-7g-3p AXIN2 -1.14091000722297 8.32736018188759e-19 0.113841868770703 0.752977397700815 MirTarget -0.333163518873582 0.0112609172880632 NA NA NA hsa-miR-15b-5p AXIN2 0.230566941413564 0.0824765001857479 0.113841868770703 0.752977397700815 miRTarBase;MirTarget;miRNATAP -0.445214007102522 0.000810754926318775 NA NA NA hsa-miR-16-2-3p AXIN2 -0.0336420826463706 0.805158952566973 0.113841868770703 0.752977397700815 mirMAP -0.637896819806337 6.99346379238779e-07 NA NA NA hsa-miR-16-5p AXIN2 -0.398577235179603 0.000101598495180191 0.113841868770703 0.752977397700815 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.492511513287746 0.00421170477125135 NA NA NA hsa-miR-195-3p AXIN2 -1.09375690196245 4.70092324819807e-09 0.113841868770703 0.752977397700815 mirMAP -0.313128484413814 0.000828518151480385 NA NA NA hsa-miR-195-5p AXIN2 -1.85907534356434 1.47434041676402e-22 0.113841868770703 0.752977397700815 MirTarget;miRNATAP -0.245874041969712 0.00506110437798971 NA NA NA hsa-miR-26b-3p AXIN2 -1.25503731613309 4.45390890119649e-27 0.113841868770703 0.752977397700815 MirTarget -0.591476065389494 2.94301063245798e-05 NA NA NA hsa-miR-326 AXIN2 -1.881935132554 1.68087316863775e-21 0.113841868770703 0.752977397700815 miRanda -0.362520003418692 1.98590653589597e-05 NA NA NA hsa-miR-338-5p AXIN2 -0.221898432884726 0.252390988727086 0.113841868770703 0.752977397700815 miRNATAP -0.342154956032422 0.000172654921949776 NA NA NA hsa-miR-424-5p AXIN2 -2.62653257498508 2.38997974737991e-50 0.113841868770703 0.752977397700815 MirTarget;miRNATAP -0.191832991796132 0.0301808709524209 NA NA NA hsa-miR-497-5p AXIN2 -1.41371173021948 7.09278946477743e-17 0.113841868770703 0.752977397700815 MirTarget;miRNATAP -0.294042209891213 0.00328690230713159 NA NA NA hsa-miR-616-3p AXIN2 -0.699516741506971 1.82225985970292e-05 0.113841868770703 0.752977397700815 MirTarget -0.422833368838949 7.60561180413777e-05 NA NA NA hsa-miR-148a-3p B4GALT2 -0.748702855596996 3.93313343865641e-07 0.259508874283337 0.00786071208383262 miRNATAP -0.131729353475028 3.23468076819227e-05 NA NA NA hsa-miR-148a-3p B4GALT5 -0.748702855596996 3.93313343865641e-07 -0.523612200569853 3.66546987358603e-06 MirTarget;miRNATAP -0.326881094016732 4.65665310573306e-20 NA NA NA hsa-miR-148a-3p BAZ2A -0.748702855596996 3.93313343865641e-07 0.461073155925693 4.28128289777929e-08 mirMAP;miRNATAP -0.15432037562048 1.83068832398087e-08 NA NA NA hsa-miR-148a-3p BCL2 -0.748702855596996 3.93313343865641e-07 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.309765293468013 4.08540378699783e-10 21455217;23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a ; colorectal cancer;pancreatic cancer hsa-miR-148a-3p BCL9L -0.748702855596996 3.93313343865641e-07 0.488893976862282 7.48836967061567e-05 mirMAP -0.252714926187226 2.14292604768469e-10 NA NA NA hsa-miR-148a-5p BDNF -0.767626696027761 1.08359477494797e-06 0.0509404608382562 0.831886089502745 mirMAP -0.25723398567524 0.00044233258998089 NA NA NA hsa-miR-148a-3p BHLHE41 -0.748702855596996 3.93313343865641e-07 -0.40186061667449 0.159058094290555 MirTarget -0.822231025139073 2.60286252642047e-20 NA NA NA hsa-miR-148a-5p BICD1 -0.767626696027761 1.08359477494797e-06 0.798278862498021 0.000395688075323181 mirMAP -0.399613693074808 5.0436884353982e-09 NA NA NA hsa-let-7b-5p BIRC5 -0.959013717270803 5.95127281258643e-11 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -0.714894665750299 6.76492235439612e-11 NA NA NA hsa-miR-101-3p BIRC5 -1.48176407980989 3.98950707385704e-31 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -1.3265120823297 7.97415084582345e-32 NA NA NA hsa-miR-10a-5p BIRC5 -1.47723516092033 7.27299669108673e-16 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -0.713644309178663 4.2990229259411e-17 NA NA NA hsa-miR-203a-3p BIRC5 -1.34362479226226 8.69374456831293e-05 4.49515004999251 9.61981227851246e-50 miRTarBase -0.125858297754976 0.00935408966011575 22713668;27714672 Luciferase assays were also performed to validate BIRC5 and LASP1 as miR-203 targets; Both miR-203 and BIRC5 siRNA signicantly inhibited cell proliferation in TNBC cells; Moreover up-regulated of BIRC5 and LASP1 was able to abrogate the effects induced by transfection with the miR-203 precursor;miR 203 is a predictive biomarker for colorectal cancer and its expression is associated with BIRC5; The purpose of this study was to explore the role of miR-203 in colorectal cancer CRC and evaluate the correlation between miR-203 and BIRC5; Finally miR-203 expression was negatively associated with that of BIRC5 r = -0.8150 P < 0.05 ; breast cancer;colorectal cancer hsa-miR-218-5p BIRC5 -0.500091158894849 0.0398595700240766 4.49515004999251 9.61981227851246e-50 miRTarBase;MirTarget -0.141730591808928 0.0393259754882198 25473903;25900794;26442524 Survivin BIRC5 was subsequently identified as an important cervical cancer target of miR-218 using in silico prediction mRNA profiling and quantitative real-time PCR qRT-PCR;miR-218 binds survivin BIRC5 mRNA 3'-UTR and down-regulated reporter luciferase activity;MiR-218 promoted apoptosis inhibited cell proliferation and caused cell cycle arrest in CRC cells by suppressing BIRC5 expression; In conclusion we demonstrated that high miR-218 expression had a positive prognostic value in 5-FU-based treatments for CRC patients and discovered a novel mechanism mediated by miR-218 to promote apoptosis and to function synergistically with 5-FU to promote chemosensitivity by suppressing BIRC5 and TS in CRC ;; cervical and endocervical cancer;breast cancer;colorectal cancer hsa-miR-30c-5p BIRC5 -0.432111642767632 0.000159764714931007 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -0.45333717178008 0.00191124919706276 NA NA NA hsa-miR-335-5p BIRC5 -1.61347836513558 1.62757083289711e-19 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate;MirTarget -0.501439997555754 1.3266718457985e-08 23232114 Genetic variation in a miR 335 binding site in BIRC5 alters susceptibility to lung cancer in Chinese Han populations; In support of the postulation that the 3' UTR SNP may directly affect miRNA-binding site reporter gene assays indicated BIRC5 was a direct target of miR-335 and the rs2239680 T>C change resulted in altered regulation of BIRC5 expression; Our findings defined a 3' UTR SNP in human BIRC5 oncogene that may increase individual susceptibility to lung cancer probably by attenuating the interaction between miR-335 and BIRC5 lung cancer hsa-miR-542-3p BIRC5 -1.31351015149842 3.64642423288576e-22 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate;MirTarget;miRanda -0.82408325426437 5.64539118201001e-13 NA NA NA hsa-miR-148a-3p BMF -0.748702855596996 3.93313343865641e-07 0.478799554865222 0.0182321819658814 mirMAP -0.313554651598086 1.85985160484412e-06 NA NA NA hsa-miR-148a-3p BTBD10 -0.748702855596996 3.93313343865641e-07 0.283901647603299 2.32887164783357e-05 MirTarget;miRNATAP -0.173605296764223 2.61734389373406e-16 NA NA NA hsa-miR-148a-3p BTBD3 -0.748702855596996 3.93313343865641e-07 0.299640501202244 0.00861061458292312 miRNAWalker2_validate;miRNATAP -0.165809468768616 7.41091066221071e-06 NA NA NA hsa-miR-139-5p BUB1 -2.11299531796557 8.16407076415038e-28 4.04762666744344 9.60341711300894e-48 miRanda -0.981222586322315 6.07995380621313e-51 NA NA NA hsa-miR-199a-5p BUB1 -1.98848462405923 2.0421622713753e-11 4.04762666744344 9.60341711300894e-48 miRanda -0.291631300567174 3.71128271880203e-09 NA NA NA hsa-miR-542-3p BUB1 -1.31351015149842 3.64642423288576e-22 4.04762666744344 9.60341711300894e-48 miRanda -0.668988733252235 2.14129391171968e-10 NA NA NA hsa-miR-142-3p BUB1B -1.4243101967815 1.92609481097765e-14 3.85682830100864 2.02974032557381e-43 miRanda -0.198560838022744 0.0119274709130208 NA NA NA hsa-miR-192-5p BUB1B -0.50188499512787 0.00344713341196035 3.85682830100864 2.02974032557381e-43 miRNAWalker2_validate -0.221905021279395 0.0119217114033508 NA NA NA hsa-miR-193b-3p BUB1B -0.166697207281748 0.272022543069482 3.85682830100864 2.02974032557381e-43 miRNAWalker2_validate -0.199232903598723 0.0474370924329797 NA NA NA hsa-miR-215-5p BUB1B -0.981544773246509 3.14452272477156e-05 3.85682830100864 2.02974032557381e-43 miRNAWalker2_validate -0.164346842914509 0.0099257038268172 NA NA NA hsa-miR-22-3p BUB1B -0.628561621952407 1.33755558015523e-09 3.85682830100864 2.02974032557381e-43 miRNAWalker2_validate -1.59565755962297 8.34276186949843e-33 NA NA NA hsa-miR-486-5p BUB1B -1.77766890600022 2.9071717929922e-14 3.85682830100864 2.02974032557381e-43 miRanda -0.415413021317956 1.24965935132642e-11 NA NA NA hsa-miR-148a-3p C1orf116 -0.748702855596996 3.93313343865641e-07 -1.07293974225301 0.00530380557251411 mirMAP -0.613864425757337 8.93655915053795e-07 NA NA NA hsa-miR-148a-5p C3orf14 -0.767626696027761 1.08359477494797e-06 -0.236482385252311 0.471169280353147 mirMAP -0.287783375884686 0.00416598419912574 NA NA NA hsa-miR-148a-5p C5AR1 -0.767626696027761 1.08359477494797e-06 -1.16551867305588 2.01005534320675e-11 mirMAP -0.18130113240317 0.000874146754841442 NA NA NA hsa-miR-148a-3p C5orf30 -0.748702855596996 3.93313343865641e-07 0.905488139382461 0.000488976635207195 miRNATAP -0.740736014753206 1.17959742896383e-19 NA NA NA hsa-miR-148a-5p CA12 -0.767626696027761 1.08359477494797e-06 2.34009290257016 5.88059078525048e-07 MirTarget -0.97829236650404 5.90123488929842e-12 NA NA NA hsa-miR-148a-5p CACNA1D -0.767626696027761 1.08359477494797e-06 0.0773051512884277 0.775671886109236 MirTarget;miRNATAP -0.493852630269608 1.42668490775728e-09 NA NA NA hsa-miR-148a-3p CACNA1E -0.748702855596996 3.93313343865641e-07 1.61336046300478 3.88892981462269e-05 mirMAP -0.551916698525026 1.72909128498258e-05 NA NA NA hsa-miR-148a-5p CACNA1E -0.767626696027761 1.08359477494797e-06 1.61336046300478 3.88892981462269e-05 mirMAP -0.500030282182667 3.35976169497632e-05 NA NA NA hsa-miR-148a-3p CASZ1 -0.748702855596996 3.93313343865641e-07 0.0447027176865755 0.759254760507176 miRNATAP -0.216249768226474 4.51223951061093e-06 NA NA NA hsa-miR-148a-3p CBFA2T2 -0.748702855596996 3.93313343865641e-07 1.20918131407154 1.46538376039906e-30 mirMAP -0.144699434906485 8.4503321462579e-05 NA NA NA hsa-miR-148a-5p CBFA2T2 -0.767626696027761 1.08359477494797e-06 1.20918131407154 1.46538376039906e-30 mirMAP -0.113612602047743 0.00103225167979083 NA NA NA hsa-miR-148a-3p CBX5 -0.748702855596996 3.93313343865641e-07 0.352720475583158 0.00158496538783418 mirMAP -0.154538700330372 2.1011094438904e-05 NA NA NA hsa-miR-148a-3p CCDC6 -0.748702855596996 3.93313343865641e-07 0.0486288224569229 0.487131811557696 MirTarget -0.162224288737069 1.91367643340457e-13 NA NA NA hsa-miR-148a-5p CCDC6 -0.767626696027761 1.08359477494797e-06 0.0486288224569229 0.487131811557696 MirTarget -0.133752882828886 1.40051341097525e-10 NA NA NA hsa-miR-148a-3p CCDC85A -0.748702855596996 3.93313343865641e-07 0.737521480033408 9.22662034200037e-05 miRNATAP -0.162313393513611 0.00894922650017325 NA NA NA hsa-miR-148a-5p CCDC93 -0.767626696027761 1.08359477494797e-06 1.02683291331392 1.2220077257148e-27 mirMAP -0.155068243155765 3.61335187600942e-07 NA NA NA hsa-let-7a-3p CCNA2 -0.568717557554068 1.00947202557819e-07 3.36794922367745 6.53886370047174e-43 MirTarget -0.508034164420555 3.65278492221913e-05 NA NA NA hsa-let-7b-3p CCNA2 -1.21979213547786 5.84575581584603e-17 3.36794922367745 6.53886370047174e-43 MirTarget -0.732605840868638 4.54728817669008e-18 NA NA NA hsa-let-7b-5p CCNA2 -0.959013717270803 5.95127281258643e-11 3.36794922367745 6.53886370047174e-43 miRNAWalker2_validate;miRTarBase -0.524638048172729 1.97837367658696e-09 NA NA NA hsa-let-7f-1-3p CCNA2 -0.704017923073338 7.84883628944999e-07 3.36794922367745 6.53886370047174e-43 MirTarget -0.411800166097723 9.61755775465089e-06 NA NA NA hsa-miR-130a-3p CCNA2 -1.53229181736223 2.91460363624872e-19 3.36794922367745 6.53886370047174e-43 miRNATAP -0.393381177440701 9.03577520347484e-08 NA NA NA hsa-miR-199a-5p CCNA2 -1.98848462405923 2.0421622713753e-11 3.36794922367745 6.53886370047174e-43 miRanda -0.274665722447149 1.39754779993059e-10 NA NA NA hsa-miR-22-3p CCNA2 -0.628561621952407 1.33755558015523e-09 3.36794922367745 6.53886370047174e-43 MirTarget -1.21746436700899 3.56641376559019e-24 25596928 The sequence of miR-22 which is conserved in mice rats humans and other mammalians aligns with the sequence of 3'-UTR of CCNA2; Chenodeoxycholic acid treatment and miR-22 mimics reduced CCNA2 protein and increased the number of G0/G1 Huh7 and HCT116 cells; In humans the expression levels of miR-22 and CCNA2 are inversely correlated in liver and colon cancers liver cancer hsa-miR-27b-3p CCNA2 -0.823491817819754 9.20935302746823e-14 3.36794922367745 6.53886370047174e-43 miRNATAP -0.54120082992627 3.46716161944693e-06 NA NA NA hsa-miR-29a-3p CCNA2 -0.856762511178136 4.65330336378459e-12 3.36794922367745 6.53886370047174e-43 MirTarget -0.878689289923181 3.31167697738131e-18 NA NA NA hsa-miR-29b-1-5p CCNA2 -0.538946836809295 0.00102913307251186 3.36794922367745 6.53886370047174e-43 MirTarget -0.331466426463458 3.78367154695011e-05 NA NA NA hsa-miR-29b-3p CCNA2 -0.348885528720517 0.0121441341291285 3.36794922367745 6.53886370047174e-43 MirTarget -0.589199607558879 3.67803340321416e-10 NA NA NA hsa-miR-29c-3p CCNA2 -1.4367517608807 1.61767774905781e-21 3.36794922367745 6.53886370047174e-43 MirTarget -0.922743011617596 1.63915073620724e-32 NA NA NA hsa-miR-374b-5p CCNA2 -0.307538028546424 0.0030079617545972 3.36794922367745 6.53886370047174e-43 mirMAP -0.32681314307052 0.0114301592113977 NA NA NA hsa-miR-486-5p CCNA2 -1.77766890600022 2.9071717929922e-14 3.36794922367745 6.53886370047174e-43 miRanda -0.275730733902838 4.10950790707083e-07 NA NA NA hsa-let-7b-5p CCNB1 -0.959013717270803 5.95127281258643e-11 3.15540953438863 5.73583669464518e-46 miRNAWalker2_validate -0.536702047843919 1.21768540248182e-11 NA NA NA hsa-miR-139-5p CCNB1 -2.11299531796557 8.16407076415038e-28 3.15540953438863 5.73583669464518e-46 miRanda -0.800903870286373 3.33153076219979e-55 NA NA NA hsa-miR-142-5p CCNB1 -1.44575553250033 1.18797044680592e-13 3.15540953438863 5.73583669464518e-46 MirTarget -0.146430294535015 0.0152842140616675 NA NA NA hsa-miR-148a-3p CCT6A -0.748702855596996 3.93313343865641e-07 0.807199846325453 3.99983471227829e-24 MirTarget -0.142589901920738 1.49586171325104e-07 NA NA NA hsa-miR-148a-5p CD109 -0.767626696027761 1.08359477494797e-06 1.83897478409166 1.63112992514376e-11 mirMAP -0.348687810338943 4.40625509113784e-05 NA NA NA hsa-miR-148a-5p CD2AP -0.767626696027761 1.08359477494797e-06 0.18229378199329 0.0422581902873597 mirMAP -0.13788998889424 3.69952883861619e-07 NA NA NA hsa-miR-148a-5p CD44 -0.767626696027761 1.08359477494797e-06 -0.0861213298199726 0.717927779502077 mirMAP -0.310480738209005 1.83991271476076e-05 23861222 In MHCC97H and MHCC97L cells over-expression of miR-148a blocked the EMT process attenuated the expression of CD90 and CD44 biomarkers for liver cancer stem cells and inhibited their migratory capacity liver cancer hsa-miR-148a-5p CD93 -0.767626696027761 1.08359477494797e-06 0.152893293585773 0.246481042677798 mirMAP -0.237511761345214 2.12155470159575e-09 NA NA NA hsa-miR-192-5p CDC20 -0.50188499512787 0.00344713341196035 4.43876134810924 2.33731245396441e-49 miRNAWalker2_validate -0.257887721839452 0.00747315576024174 NA NA NA hsa-miR-215-5p CDC20 -0.981544773246509 3.14452272477156e-05 4.43876134810924 2.33731245396441e-49 miRNAWalker2_validate -0.210290018213749 0.00250187708869541 NA NA NA hsa-miR-23b-3p CDC20 -0.530561587109023 5.43807206823652e-07 4.43876134810924 2.33731245396441e-49 miRNAWalker2_validate -0.727746315213922 2.45876854567768e-06 NA NA NA hsa-miR-30a-5p CDC20 -0.626257932887855 0.000108198196973765 4.43876134810924 2.33731245396441e-49 miRNAWalker2_validate -0.686824996889202 5.1373930712059e-12 NA NA NA hsa-miR-29c-3p CDC23 -1.4367517608807 1.61767774905781e-21 0.463635495366116 5.65757358389337e-10 miRNAWalker2_validate -0.137258097204054 2.34594396923131e-09 NA NA NA hsa-miR-148a-3p CDC25B -0.748702855596996 3.93313343865641e-07 0.802575978153976 1.68584041760539e-08 miRNAWalker2_validate;miRNATAP -0.29297329943429 2.56785527501486e-10 25341915 Gene CDC25B might be the target gene of miR-148a according to the results of targetscan; CDC25B may be the target gene of miR-148a that plays a role in tumor suppressor gastric cancer hsa-miR-146b-5p CDH1 0.419719546795449 0.0457375823220155 -0.925620688902025 3.54334396234e-05 miRanda -0.209827116364557 5.56204266800899e-05 NA NA NA hsa-miR-185-5p CDH1 0.480006257154717 6.35758891340152e-07 -0.925620688902025 3.54334396234e-05 MirTarget -0.447644587025903 7.92400318750844e-05 27212161;24025511 We also found that ectopic expression of miR-185 reversed EMT via the up-regulation of E-cadherin and down-regulation of vimentin in epithelial and mesenchymal HCC cells;After transfection of miR-185 inhibitor into KYSE30 the expression of E-cadherin a downstream protein of Six1 was observed under confocal microscope; After transfection of miR-185 inhibitorthe expression level of E-cadherin decreased ; liver cancer;esophageal cancer hsa-miR-186-5p CDH1 -0.060103391373687 0.535288717081205 -0.925620688902025 3.54334396234e-05 mirMAP -0.271690734682459 0.0182700262180118 NA NA NA hsa-miR-616-5p CDH1 0.150569904638223 0.402836556304524 -0.925620688902025 3.54334396234e-05 MirTarget;mirMAP -0.142138556800114 0.0208629153342258 NA NA NA hsa-miR-139-5p CDK1 -2.11299531796557 8.16407076415038e-28 3.60092865588574 2.53758251358007e-48 miRanda -0.838938956041355 1.17302084660509e-46 NA NA NA hsa-miR-193b-3p CDK1 -0.166697207281748 0.272022543069482 3.60092865588574 2.53758251358007e-48 miRNAWalker2_validate -0.247245044417844 0.00581826116259039 NA NA NA hsa-miR-195-3p CDK1 -1.09375690196245 4.70092324819807e-09 3.60092865588574 2.53758251358007e-48 MirTarget -0.373417267400659 1.70004237381144e-07 NA NA NA hsa-miR-378a-5p CDK1 -1.58667444700188 3.19640857320504e-17 3.60092865588574 2.53758251358007e-48 MirTarget -0.547488328475554 2.76743919236473e-16 NA NA NA hsa-miR-486-5p CDK1 -1.77766890600022 2.9071717929922e-14 3.60092865588574 2.53758251358007e-48 miRanda -0.358602044004862 6.63525634192938e-11 NA NA NA hsa-miR-148a-3p CDK19 -0.748702855596996 3.93313343865641e-07 0.118030592068031 0.294061978811636 miRNAWalker2_validate;MirTarget;miRNATAP -0.236428879384442 4.30907764913248e-11 NA NA NA hsa-miR-148a-3p CDK5R1 -0.748702855596996 3.93313343865641e-07 1.08475307136185 2.13782053288791e-11 MirTarget;miRNATAP -0.168450901534998 0.00186813487415298 NA NA NA hsa-miR-139-5p CDK7 -2.11299531796557 8.16407076415038e-28 0.491707717966495 7.16261478943003e-09 miRanda -0.14310504808171 4.57209013484235e-13 NA NA NA hsa-miR-542-3p CDK7 -1.31351015149842 3.64642423288576e-22 0.491707717966495 7.16261478943003e-09 miRanda -0.177460362938327 8.63098208373725e-10 NA NA NA hsa-miR-590-3p CDK7 -0.473167498047808 1.76652934637227e-05 0.491707717966495 7.16261478943003e-09 miRanda -0.178615786936345 2.1764183873582e-06 NA NA NA hsa-miR-181a-5p CDKN1B 0.250113435902954 0.0551933249319293 -0.231452033928625 0.00482071055692889 miRNAWalker2_validate;miRTarBase -0.134068475887496 1.13890102336643e-05 NA NA NA hsa-miR-221-3p CDKN1B 1.12244756358612 3.48370308238012e-13 -0.231452033928625 0.00482071055692889 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.153438831523776 5.56071406720925e-10 20146005;23637992;19953484;23939688;19126397;23967190;17569667;22992757;17721077;20461750 Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression staging;tumorigenesis;progression;;;;;;;;poor survival liver cancer;breast cancer;glioblastoma;breast cancer;melanoma;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-222-3p CDKN1B 1.08574156066353 1.76407192348131e-11 -0.231452033928625 0.00482071055692889 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.140430207935426 3.56247154847449e-09 19953484;26912358;24895988;24137356;17569667;27282281;20461750 Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;Besides microvesicle marker characterization we evidenced that miR-222 exosomal expression mostly reflected its abundance in the cells of origin correctly paralleled by repression of its target genes such as p27Kip1 and induction of the PI3K/AKT pathway thus confirming its functional implication in cancer;MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;miR 222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1; miR-222 upregulation induced an enhancement of ovarian cancer cell proliferation potential possibly by downregulating its target P27Kip1; A bioinformatic analysis showed that the 3'-UTR of the P27Kip1 mRNA contained a highly-conserved putative miR-222 binding site; Luciferase reporter assays demonstrated that P27Kip1 was a direct target of miR-222; Consistently there was an inverse correlation between the P27Kip1 and miR-222 expression levels in the ovarian cancer cell lines and tissues;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;miR 222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27kip1 expression; Immunofluorescence showed that miR-222 altered the subcellular location of p27kip1 in nucleus; The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis and arrested the cells in G1 phase accompanied by more expressions of p27kip1 especially in nucleus; Taken together the results found that miR-222 induced Adr-resistance at least in part via suppressing p27kip1 expression and altering its subcellular localization and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression ;;tumorigenesis;;;drug resistance;poor survival glioblastoma;melanoma;cervical and endocervical cancer;ovarian cancer;prostate cancer;breast cancer;ovarian cancer hsa-miR-24-3p CDKN1B -0.257825594021966 0.00689742600215061 -0.231452033928625 0.00482071055692889 miRNAWalker2_validate;miRNATAP -0.125575697425242 0.00293958904599202 26847530;26044523 The biological significance of miR-24 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets p27 CDKN1B and p16 CDK2NA was investigated;With the bioinformatic method we further identified that p27Kip1 is a direct target of miR-24-3p and its protein level was negatively regulated by miR-24-3p ; prostate cancer;breast cancer hsa-miR-98-5p CDKN1B -0.0487189107419432 0.715911066732548 -0.231452033928625 0.00482071055692889 miRNAWalker2_validate -0.150589087046664 3.98220273478164e-07 NA NA NA hsa-miR-107 CDKN2B 0.241662461253461 0.0170788899505389 1.37191742600332 3.8601745589837e-15 PITA -0.22214715039643 0.0113151536408877 NA NA NA hsa-miR-126-5p CDKN2B -0.428561469405594 6.6035585844222e-05 1.37191742600332 3.8601745589837e-15 mirMAP -0.331524443678709 4.86520309619025e-05 NA NA NA hsa-miR-144-3p CDKN2B -2.97536914478815 6.00546047309683e-28 1.37191742600332 3.8601745589837e-15 MirTarget -0.165363817374004 2.99908004062454e-08 NA NA NA hsa-miR-382-5p CDKN2B -0.71884748690977 0.00849172229801356 1.37191742600332 3.8601745589837e-15 mirMAP -0.101243601276092 0.00159366073719854 NA NA NA hsa-miR-450b-5p CDKN2B -1.34333360369432 2.68386079790462e-17 1.37191742600332 3.8601745589837e-15 mirMAP -0.177653728760579 0.000849213139863512 NA NA NA hsa-miR-451a CDKN2B -2.1025161666445 6.82555767537341e-17 1.37191742600332 3.8601745589837e-15 MirTarget -0.162386705840671 1.05027558906518e-06 NA NA NA hsa-miR-486-5p CDKN2B -1.77766890600022 2.9071717929922e-14 1.37191742600332 3.8601745589837e-15 miRanda -0.19221239071621 9.16912999787263e-08 NA NA NA hsa-miR-450b-5p CDKN2C -1.34333360369432 2.68386079790462e-17 2.08821471271675 1.38541951717446e-30 miRNATAP -0.407319031602086 4.73616061228169e-13 NA NA NA hsa-miR-542-3p CDKN2C -1.31351015149842 3.64642423288576e-22 2.08821471271675 1.38541951717446e-30 miRanda -0.51609932750582 1.59421631749972e-15 NA NA NA hsa-miR-148a-3p CDS1 -0.748702855596996 3.93313343865641e-07 -0.320537686923673 0.401665556750745 miRNATAP -0.62382426469952 4.34120367054976e-07 NA NA NA hsa-miR-148a-5p CECR6 -0.767626696027761 1.08359477494797e-06 0.392226039618319 0.0399877472539567 mirMAP -0.35870800262286 4.33825899405627e-10 NA NA NA hsa-miR-148a-3p CELSR1 -0.748702855596996 3.93313343865641e-07 0.364471201671942 0.107126693908784 MirTarget -0.208015418033919 0.00486931864679582 NA NA NA hsa-miR-148a-3p CENPP -0.748702855596996 3.93313343865641e-07 1.58562892488644 4.26649488498792e-22 mirMAP -0.152643938238212 0.00690454136350145 NA NA NA hsa-miR-148a-3p CEP55 -0.748702855596996 3.93313343865641e-07 2.874986535696 2.48808404875451e-31 MirTarget -0.761706377152175 6.27881131213199e-20 NA NA NA hsa-miR-148a-3p CHST1 -0.748702855596996 3.93313343865641e-07 0.685732737107354 0.00199386228629166 MirTarget -0.733860751670885 6.4615399196172e-27 NA NA NA hsa-miR-148a-3p CHST3 -0.748702855596996 3.93313343865641e-07 -0.197541925922359 0.301297241668114 mirMAP -0.543542392297203 7.99217300956161e-20 NA NA NA hsa-miR-15a-5p CHUK 0.349521211668244 0.000770735998804736 -0.19932080126218 0.00863163957240649 miRNAWalker2_validate;miRTarBase;MirTarget -0.122536038974783 0.000565424625908096 NA NA NA hsa-miR-15b-5p CHUK 0.230566941413564 0.0824765001857479 -0.19932080126218 0.00863163957240649 MirTarget -0.118017359725558 2.06238744655946e-05 NA NA NA hsa-miR-16-5p CHUK -0.398577235179603 0.000101598495180191 -0.19932080126218 0.00863163957240649 miRNAWalker2_validate;miRTarBase;MirTarget -0.150607357209835 2.62400382273556e-05 NA NA NA hsa-miR-23a-3p CHUK -0.178875974460574 0.135978273540604 -0.19932080126218 0.00863163957240649 MirTarget -0.100438227795724 0.00114468004476388 NA NA NA hsa-miR-339-5p CHUK 0.280589919878422 0.0355660282647215 -0.19932080126218 0.00863163957240649 miRanda -0.12221351609504 8.92727609693918e-06 NA NA NA hsa-miR-590-5p CHUK -0.103355559980404 0.310027295317092 -0.19932080126218 0.00863163957240649 miRanda -0.11766978557823 0.00128889069327197 NA NA NA hsa-miR-148a-3p CIITA -0.748702855596996 3.93313343865641e-07 0.267952742521313 0.180108388943748 mirMAP -0.264823270812163 4.50203150079269e-05 NA NA NA hsa-miR-148a-3p CIT -0.748702855596996 3.93313343865641e-07 0.474922759349472 0.00990742942099617 miRNATAP -0.151727650508733 0.0118981318787957 NA NA NA hsa-miR-148a-3p CNIH4 -0.748702855596996 3.93313343865641e-07 1.00667194671376 1.24728003967923e-20 MirTarget -0.10088285082769 0.00643146069475781 NA NA NA hsa-miR-148a-5p CNIH4 -0.767626696027761 1.08359477494797e-06 1.00667194671376 1.24728003967923e-20 mirMAP -0.107140772268116 0.0020066884543873 NA NA NA hsa-miR-148a-3p CNN1 -0.748702855596996 3.93313343865641e-07 0.406994515021795 0.0928241685509811 miRNATAP -0.497670787813982 1.39514602371003e-10 NA NA NA hsa-miR-148a-5p CNNM1 -0.767626696027761 1.08359477494797e-06 0.33952854155628 0.46753682532046 MirTarget -0.478159358921923 0.000812447775750469 NA NA NA hsa-miR-148a-3p CNTN4 -0.748702855596996 3.93313343865641e-07 -2.23654576737969 6.05144113270082e-19 miRNATAP -0.267873351717936 0.00180831931684552 NA NA NA hsa-miR-148a-3p COL4A1 -0.748702855596996 3.93313343865641e-07 1.64595918385092 3.29766696573805e-22 miRNATAP -0.506696445918838 1.45523526380931e-19 NA NA NA hsa-miR-148a-5p COL5A2 -0.767626696027761 1.08359477494797e-06 0.523957991319594 0.00488074596388077 MirTarget -0.431115785321945 7.43046788070165e-15 NA NA NA hsa-miR-148a-3p CPD -0.748702855596996 3.93313343865641e-07 0.599470550586786 4.65999718552314e-06 MirTarget;miRNATAP -0.141323955894331 0.00103892821521111 NA NA NA hsa-miR-148a-5p CPD -0.767626696027761 1.08359477494797e-06 0.599470550586786 4.65999718552314e-06 mirMAP -0.212520796545388 1.07709925097459e-07 NA NA NA hsa-miR-148a-3p CS -0.748702855596996 3.93313343865641e-07 0.630496195920363 1.14583127791941e-12 miRNATAP -0.1545115311895 1.37525350059388e-07 NA NA NA hsa-miR-148a-3p CSF1 -0.748702855596996 3.93313343865641e-07 -0.5853277886696 0.00153229238014141 miRNATAP -0.256768312227477 2.00461329540934e-05 NA NA NA hsa-miR-148a-5p CSNK1E -0.767626696027761 1.08359477494797e-06 0.608336779934033 9.56780795613581e-12 miRNATAP -0.245152102120518 4.84178312131527e-20 NA NA NA hsa-miR-148a-5p CSNK1G1 -0.767626696027761 1.08359477494797e-06 0.5242161160821 3.26619328715997e-11 mirMAP -0.109337777697705 8.15024331246006e-06 NA NA NA hsa-miR-148a-3p CSPG4 -0.748702855596996 3.93313343865641e-07 2.20938998217354 1.93186590158878e-35 miRNATAP -0.47109794771531 1.88996499141413e-14 NA NA NA hsa-miR-330-3p CTNNB1 -0.332364259424489 0.0316051913061459 0.00180452674840392 0.983564078864382 MirTarget;PITA;miRNATAP -0.128940103294471 3.76576237893285e-06 NA NA NA hsa-miR-331-3p CTNNB1 -0.283974346994635 0.0373785411053202 0.00180452674840392 0.983564078864382 miRNAWalker2_validate -0.113207881387487 0.000273720190926097 NA NA NA hsa-miR-148a-3p CTTNBP2NL -0.748702855596996 3.93313343865641e-07 0.0265420118187079 0.819395334474897 MirTarget;miRNATAP -0.400219991755329 7.16863410683787e-30 NA NA NA hsa-miR-27a-3p CUL1 -0.370807380415112 0.00875721956202713 -0.117901782494851 0.10228448838388 miRNAWalker2_validate -0.100449098638373 4.43211535246804e-05 NA NA NA hsa-miR-30b-5p CUL2 -0.54056186708617 2.44688760798341e-05 0.221493309659475 0.000775493336759859 MirTarget;mirMAP;miRNATAP -0.104130690012811 2.59410967342164e-05 NA NA NA hsa-miR-148a-5p CXorf23 -0.767626696027761 1.08359477494797e-06 0.430761186308626 9.49129189428509e-06 miRNATAP -0.109875581589136 0.000238957297451093 NA NA NA hsa-miR-148a-3p CYTH3 -0.748702855596996 3.93313343865641e-07 0.609753795487233 1.49167558303658e-06 MirTarget;miRNATAP -0.287885455378431 1.71620007242084e-12 NA NA NA hsa-miR-148a-5p CYTIP -0.767626696027761 1.08359477494797e-06 -1.30828352000163 2.48007188651946e-08 MirTarget -0.169583627577875 0.0205859728787413 NA NA NA hsa-miR-148a-5p DDR1 -0.767626696027761 1.08359477494797e-06 0.19463335306942 0.483361341487924 miRNATAP -0.674507529112087 2.00353520122618e-16 NA NA NA hsa-miR-148a-3p DMPK -0.748702855596996 3.93313343865641e-07 0.656614767219979 1.80881732624839e-07 MirTarget -0.30785961316669 2.61560071271051e-14 NA NA NA hsa-miR-148a-3p DNAJC18 -0.748702855596996 3.93313343865641e-07 0.379578184862879 0.00785785435417525 MirTarget -0.482256465265997 2.60755726904746e-28 NA NA NA hsa-miR-148a-3p DNER -0.748702855596996 3.93313343865641e-07 1.29255242782277 0.00336209766653278 MirTarget;miRNATAP -1.04467659125513 1.06494193352452e-13 NA NA NA hsa-miR-148a-5p DNM3 -0.767626696027761 1.08359477494797e-06 1.36736147579245 1.02047986055836e-15 mirMAP -0.175048186676175 0.00119599740090889 NA NA NA hsa-miR-148a-3p DNMT1 -0.748702855596996 3.93313343865641e-07 1.07072601011042 3.56408109602049e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.222357078113257 4.38571155341952e-07 25865490;26111756;25950085;22167392 miR 148a dependent apoptosis of bladder cancer cells is mediated in part by the epigenetic modifier DNMT1; We additionally show that miR-148a exerts this effect partially by attenuating expression of DNA methyltransferase 1 DNMT1;Moreover we found that miR-148a appeared to be a target of bufalin and miR-148a further regulated DNMT1 and p27 to control the stemness of OS cells;The Interplay Between miR 148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy; We discovered the expression level of miR-148a significantly decreased in pancreatic cancer tissues whereas that of DNMT1 increased; In ASPC-1 cancer cells the overexpression of miR-148a led to a decreased level of DNMT1 and reduced the proliferation and metastasis of ASPC-1 cells; Interestingly it was shown that the DNMT1 inhibition enhanced the expression of miR-148a; In vivo studies demonstrated that the tumorigenesis of ASPC-1 was significantly arrested by either the overexpression of miR-148a or the inhibition of DNMT1;Studies have shown that microRNA-148a miR-148a was proved to be silenced while DNA methyltransferase 1 DNMT1 was over-expressed in gastric cancer; But the mechanism of aberrant expression of miR-148a and DNMT1 and their relationships in gastric cancer are still unknown; The aims of this study were to investigate the expression profile of miR-148a and DNMT1 and reveal whether they have any relationships; We used reverse-transcriptase quantitative real-time PCR methylation-specific PCR and Western blot to measure the level of miR-148a expression DNA methylation level and DNMT1 expression respectively; DNMT1 was over-expressed in primary tumors and cell lines while knockdown of DNMT1 using siRNA could decrease methylation level of miR-148a promoter and restore its expression; Furthermore ectopic over-expression of miR-148a in cancer cell lines caused reduction in DNMT1 expression and inhibited cell proliferation but no obvious change was found in apoptosis rate; These results suggest that miR-148a is inactivated by DNA hypermethylation of promoter region in gastric cancer which is mediated through DNMT1 over-expression; Additionally the silence of miR-148a reduces its suppression to DNMT1 in gastric cancer and this may in turn result in over-expression of DNMT1 and promote DNA hypermethylation ;;metastasis;tumorigenesis; bladder cancer;sarcoma;pancreatic cancer;gastric cancer hsa-miR-148a-5p DNMT3A -0.767626696027761 1.08359477494797e-06 1.18820126942617 6.93286101815213e-19 mirMAP -0.120836170814468 0.00478930858196754 NA NA NA hsa-miR-148a-3p DNMT3B -0.748702855596996 3.93313343865641e-07 1.61793226634891 7.24162651287187e-19 miRNAWalker2_validate;miRTarBase -0.192692774033865 0.00195212252979673 20841507 Low ERG expressers presented with down-regulation of genes involved in the DNA-methylation machinery and up-regulation of miR-148a which targets DNMT3B acute myeloid leukemia hsa-miR-148a-3p DOCK3 -0.748702855596996 3.93313343865641e-07 1.89917396490138 8.65073654235979e-17 miRNATAP -0.283819265304344 0.000239484898895635 NA NA NA hsa-miR-148a-3p DOCK6 -0.748702855596996 3.93313343865641e-07 0.921029085267333 4.1395349862803e-24 MirTarget -0.242316323155687 1.46606073675809e-15 NA NA NA hsa-miR-148a-3p DOT1L -0.748702855596996 3.93313343865641e-07 0.585703387018246 2.71031330751421e-07 mirMAP -0.105927324502338 0.00490233486966271 NA NA NA hsa-miR-148a-3p DPP3 -0.748702855596996 3.93313343865641e-07 0.367930824003208 7.7340018984217e-06 miRNATAP -0.13173717479097 8.52306013192258e-07 NA NA NA hsa-miR-148a-3p DSTYK -0.748702855596996 3.93313343865641e-07 1.00504202460505 2.41375496861128e-19 miRNAWalker2_validate -0.200328046355734 1.06054134520476e-07 NA NA NA hsa-miR-148a-3p DTNA -0.748702855596996 3.93313343865641e-07 1.85440917822318 1.2434230849807e-10 miRNATAP -0.419016677215032 1.19731795266872e-05 NA NA NA hsa-miR-148a-5p DTNA -0.767626696027761 1.08359477494797e-06 1.85440917822318 1.2434230849807e-10 mirMAP -0.466892951975804 1.7308211469552e-07 NA NA NA hsa-miR-148a-5p DTX3 -0.767626696027761 1.08359477494797e-06 0.0814741725691028 0.674125374025254 mirMAP -0.351059453543964 1.68854367559999e-09 NA NA NA hsa-miR-148a-3p DYRK1B -0.748702855596996 3.93313343865641e-07 0.432980103635144 0.000665367161987308 miRNATAP -0.226263129684861 3.85397710195182e-08 NA NA NA hsa-miR-148a-3p E2F3 -0.748702855596996 3.93313343865641e-07 0.679179223655044 3.98775697474768e-07 miRNATAP -0.286439887340466 4.00406934916546e-11 NA NA NA hsa-miR-148a-3p E2F7 -0.748702855596996 3.93313343865641e-07 3.06815276582178 3.19808997821633e-30 miRNATAP -0.243822828282522 0.00994914998543976 NA NA NA hsa-miR-148a-5p ECT2 -0.767626696027761 1.08359477494797e-06 2.35414440886737 1.90301512891325e-30 miRNATAP -0.319241251303204 2.01886023337258e-06 NA NA NA hsa-miR-148a-5p EDA -0.767626696027761 1.08359477494797e-06 -0.451949726910863 0.1007806774962 mirMAP -0.503909826625111 1.24165699218891e-09 NA NA NA hsa-miR-148a-5p EDNRA -0.767626696027761 1.08359477494797e-06 -0.0247461473937958 0.894159315280006 mirMAP -0.455222895844288 1.06288883191444e-16 NA NA NA hsa-miR-148a-5p EFHC1 -0.767626696027761 1.08359477494797e-06 0.848078375402764 8.29240893300235e-12 mirMAP -0.230864799497127 1.68003701401744e-09 NA NA NA hsa-miR-148a-3p EFNB2 -0.748702855596996 3.93313343865641e-07 0.0997333215214327 0.477026029683948 MirTarget;miRNATAP -0.186304808477715 4.15657096208185e-05 NA NA NA hsa-miR-146a-5p EGFR -0.742958238440575 0.000765983177482633 -1.01672920195188 6.69873186671412e-07 miRNAWalker2_validate -0.224421920698198 6.22524592924969e-07 24895573;25242818;22161865;25596948;25417703;23555954;24839931;21632853 Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;;progression;;;;; liver cancer;pancreatic cancer;prostate cancer;breast cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-146b-5p EGFR 0.419719546795449 0.0457375823220155 -1.01672920195188 6.69873186671412e-07 miRNATAP -0.221138858293073 3.44879306513365e-06 NA NA NA hsa-miR-148b-5p EGFR 0.295777213389605 0.0255749859535438 -1.01672920195188 6.69873186671412e-07 mirMAP -0.233539600600063 0.00227279523782391 NA NA NA hsa-miR-155-5p EGFR 0.0108524225071784 0.95651331033505 -1.01672920195188 6.69873186671412e-07 miRNAWalker2_validate;MirTarget -0.128466970088693 0.0115801509528144 NA NA NA hsa-miR-17-5p EGFR 0.698861147045461 2.43854106455398e-05 -1.01672920195188 6.69873186671412e-07 TargetScan -0.161590563481239 0.00764134099999989 NA NA NA hsa-miR-188-5p EGFR 1.11646899351496 9.56686958408598e-11 -1.01672920195188 6.69873186671412e-07 mirMAP -0.300235014857475 1.22424681244032e-07 NA NA NA hsa-miR-21-5p EGFR 1.51084295924322 1.54551622173259e-34 -1.01672920195188 6.69873186671412e-07 miRNAWalker2_validate;miRTarBase -0.440371363258275 3.21604130567409e-09 24198203;20113523;24012640;24331411;26563758;19597153;26026961;20048743 In radically resected NSCLC patients the expression levels of miR-21 10b in patients with EGFR mutation were much higher than those without mutation;Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;Further the expression of miR-21 is regulated by EGFR via the activation of β-catenin and AP-1; These data indicate that a feedback loop exists between miR-21 and EGFR; These results clarify a novel association between miR-21 and EGFR in the regulation of cancer cell progression;MiR 21 overexpression is associated with acquired resistance of EGFR TKI in non small cell lung cancer;Higher expression levels of miR-21 AmiR-27a and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations;MiR 21 is an EGFR regulated anti apoptotic factor in lung cancer in never smokers; The changes in expression of some of these miRNAs including miR-21 were more remarkable in cases with EGFR mutations than in those without these mutations; In the never-smoker-derived lung adenocarcinoma cell line H3255 with mutant EGFR and high levels of p-EGFR and miR-21 antisense inhibition of miR-21 enhanced AG1478-induced apoptosis; In a never-smoker-derived adenocarcinoma cell line H441 with wild-type EGFR the antisense miR-21 not only showed the additive effect with AG1478 but also induced apoptosis by itself; These results suggest that aberrantly increased expression of miR-21 which is enhanced further by the activated EGFR signaling pathway plays a significant role in lung carcinogenesis in never-smokers as well as in smokers and is a potential therapeutic target in both EGFR-mutant and wild-type cases;Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR mutated lung cancer via nickel induced microRNA 21 expression;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status ;;progression;drug resistance;staging;drug resistance;tumorigenesis;; lung squamous cell cancer;glioblastoma;glioblastoma;lung squamous cell cancer;lung squamous cell cancer;lung cancer;lung cancer;glioblastoma hsa-miR-29a-5p EGFR -0.113555908626946 0.349622266470788 -1.01672920195188 6.69873186671412e-07 mirMAP -0.458889085026057 2.82252978142708e-08 27477273 Feedback Loop Regulation of SCAP/SREBP 1 by miR 29 Modulates EGFR Signaling Driven Glioblastoma Growth glioblastoma hsa-miR-32-3p EGFR 0.219109440121582 0.207217051619543 -1.01672920195188 6.69873186671412e-07 mirMAP -0.238124126347676 6.9947851263588e-05 NA NA NA hsa-miR-362-5p EGFR 0.717921690799312 1.68392734504524e-05 -1.01672920195188 6.69873186671412e-07 mirMAP -0.247853042376492 3.33470814837779e-05 NA NA NA hsa-miR-3682-3p EGFR 0.805600143458555 8.7874424633131e-06 -1.01672920195188 6.69873186671412e-07 mirMAP -0.12932547288846 0.0249956294814211 NA NA NA hsa-miR-374b-3p EGFR -0.137420230218985 0.305318192448799 -1.01672920195188 6.69873186671412e-07 mirMAP -0.202869152527087 0.00750806275200147 NA NA NA hsa-miR-455-5p EGFR -0.270546034117157 0.0581320703577731 -1.01672920195188 6.69873186671412e-07 miRanda -0.226922724788645 0.00135818927133814 NA NA NA hsa-miR-501-5p EGFR 1.15231083477882 2.98906150004088e-10 -1.01672920195188 6.69873186671412e-07 mirMAP -0.228828416518186 2.10663471825952e-05 NA NA NA hsa-miR-590-5p EGFR -0.103355559980404 0.310027295317092 -1.01672920195188 6.69873186671412e-07 miRanda;mirMAP -0.282971808483034 0.00478577902454241 NA NA NA hsa-miR-618 EGFR 0.13539895350352 0.517145913114103 -1.01672920195188 6.69873186671412e-07 mirMAP -0.104183567265845 0.0380128909987004 NA NA NA hsa-miR-769-5p EGFR 0.219661452072771 0.0333425465750576 -1.01672920195188 6.69873186671412e-07 mirMAP -0.501593765874938 2.76004531715872e-07 NA NA NA hsa-miR-877-5p EGFR 1.35669625926821 1.43008125755656e-11 -1.01672920195188 6.69873186671412e-07 mirMAP -0.247141034396675 1.1588258665615e-06 NA NA NA hsa-miR-15a-5p EGLN1 0.349521211668244 0.000770735998804736 0.0756107370151957 0.405502512247036 MirTarget -0.199232552642064 2.38498365947827e-06 NA NA NA hsa-miR-16-2-3p EGLN1 -0.0336420826463706 0.805158952566973 0.0756107370151957 0.405502512247036 mirMAP -0.154448651591541 1.62881459061765e-06 NA NA NA hsa-miR-16-5p EGLN1 -0.398577235179603 0.000101598495180191 0.0756107370151957 0.405502512247036 MirTarget -0.184906710341522 1.5638193085266e-05 NA NA NA hsa-miR-17-5p EGLN1 0.698861147045461 2.43854106455398e-05 0.0756107370151957 0.405502512247036 TargetScan -0.102696431475396 9.47932370331605e-05 NA NA NA hsa-miR-186-5p EGLN1 -0.060103391373687 0.535288717081205 0.0756107370151957 0.405502512247036 mirMAP -0.139054765598172 0.00251459263459613 NA NA NA hsa-miR-1976 EGLN1 -0.431472440543166 0.00324575010550946 0.0756107370151957 0.405502512247036 MirTarget -0.117052103230428 9.15621715743439e-05 NA NA NA hsa-miR-590-3p EGLN1 -0.473167498047808 1.76652934637227e-05 0.0756107370151957 0.405502512247036 miRanda;mirMAP -0.116534466317335 0.0035050444625743 NA NA NA hsa-miR-590-5p EGLN1 -0.103355559980404 0.310027295317092 0.0756107370151957 0.405502512247036 miRanda -0.196266966880368 6.27078388640176e-06 NA NA NA hsa-miR-148a-3p EGR3 -0.748702855596996 3.93313343865641e-07 -2.49025618015861 9.70314095894188e-25 MirTarget -0.209189146874948 0.0129875229995118 NA NA NA hsa-miR-148a-3p ELFN2 -0.748702855596996 3.93313343865641e-07 2.86706730299717 2.25493376503085e-09 mirMAP -0.483208813462652 0.00248298597422395 NA NA NA hsa-miR-148a-5p ELK3 -0.767626696027761 1.08359477494797e-06 -0.374593711821051 0.0677288387929772 MirTarget -0.212828923285768 0.000688020856067929 NA NA NA hsa-miR-148a-5p ENAH -0.767626696027761 1.08359477494797e-06 1.39629433723863 3.42757488063496e-20 mirMAP -0.281810315664061 4.21861206997964e-09 NA NA NA hsa-miR-148a-3p ENTPD1 -0.748702855596996 3.93313343865641e-07 0.548264152440102 1.02295823309827e-09 mirMAP -0.300291742240826 8.25145845724624e-27 NA NA NA hsa-miR-148a-5p ENTPD1 -0.767626696027761 1.08359477494797e-06 0.548264152440102 1.02295823309827e-09 mirMAP -0.241406294371077 2.0555930935846e-19 NA NA NA hsa-miR-148a-3p EPB41L1 -0.748702855596996 3.93313343865641e-07 0.134154503301847 0.605658196491617 MirTarget -0.302843609687242 0.000339392792749624 NA NA NA hsa-miR-148a-5p EPCAM -0.767626696027761 1.08359477494797e-06 -1.91096939830362 0.00205163213188168 miRNATAP -1.18671921832342 2.302548728128e-10 NA NA NA hsa-miR-148a-5p EPHA3 -0.767626696027761 1.08359477494797e-06 -1.75532340990487 1.13157153732929e-08 mirMAP -0.543872690787842 8.57606810003107e-09 NA NA NA hsa-miR-148a-3p EPN2 -0.748702855596996 3.93313343865641e-07 0.0353361937087526 0.693340512927564 MirTarget;miRNATAP -0.116478658095663 5.79350548452928e-05 NA NA NA hsa-miR-148a-3p ERC2 -0.748702855596996 3.93313343865641e-07 1.31841593023186 2.0512747793649e-05 MirTarget -0.310718760201474 0.00231511105017742 NA NA NA hsa-miR-148a-3p ERMP1 -0.748702855596996 3.93313343865641e-07 0.542622265078398 5.31729874404597e-06 MirTarget -0.255518323160464 3.01191040047704e-11 NA NA NA hsa-miR-10b-3p ETS1 2.77189254628215 2.26687582932628e-20 -0.888146453921594 7.30600721510989e-10 mirMAP -0.105519293114893 1.58415058877614e-05 NA NA NA hsa-miR-1180-3p ETS1 1.13535217859875 1.17286173228245e-09 -0.888146453921594 7.30600721510989e-10 MirTarget -0.293265031973102 8.05459469251981e-16 NA NA NA hsa-miR-130b-5p ETS1 0.170599813152408 0.337611586432771 -0.888146453921594 7.30600721510989e-10 MirTarget -0.117830624648738 0.00350746127707538 NA NA NA hsa-miR-148b-5p ETS1 0.295777213389605 0.0255749859535438 -0.888146453921594 7.30600721510989e-10 MirTarget -0.14433424168597 0.00795478698949807 NA NA NA hsa-miR-16-1-3p ETS1 0.392360028038559 0.00112481918108198 -0.888146453921594 7.30600721510989e-10 MirTarget -0.14163124063757 0.0176332220270728 NA NA NA hsa-miR-186-5p ETS1 -0.060103391373687 0.535288717081205 -0.888146453921594 7.30600721510989e-10 mirMAP -0.15329403808341 0.0411464992332332 NA NA NA hsa-miR-193a-3p ETS1 -0.117675551589896 0.309391958208578 -0.888146453921594 7.30600721510989e-10 miRanda;miRNATAP -0.206450097116881 0.000921512501112203 NA NA NA hsa-miR-221-3p ETS1 1.12244756358612 3.48370308238012e-13 -0.888146453921594 7.30600721510989e-10 miRTarBase;miRNATAP -0.163620716574743 0.000282330030340872 21711453 To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions melanoma hsa-miR-222-3p ETS1 1.08574156066353 1.76407192348131e-11 -0.888146453921594 7.30600721510989e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.114027687122358 0.00860678284178252 21711453 Constitutive activation of the ETS 1 miR 222 circuitry in metastatic melanoma; We demonstrate that the proto-oncogene ETS-1 involved in the pathogenesis of cancers of different origin is a transcriptional regulator of miR-222 by direct binding to its promoter region; Differently from 293FT cells or early stage melanomas where unphosphorylated ETS-1 represses miR-222 transcription in metastatic melanoma the constitutively Thr-38 phosphorylated fraction of ETS-1 induces miR-222; To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions staging melanoma hsa-miR-30d-3p ETS1 -0.120562286038759 0.329549534782125 -0.888146453921594 7.30600721510989e-10 mirMAP -0.123711965263521 0.0344163749253352 NA NA NA hsa-miR-362-3p ETS1 0.814007335895913 2.00108618836568e-09 -0.888146453921594 7.30600721510989e-10 miRanda -0.181573270953595 0.000463194817826299 NA NA NA hsa-miR-365a-3p ETS1 0.164591326307714 0.15325084963213 -0.888146453921594 7.30600721510989e-10 MirTarget -0.267990900609134 1.68132949421869e-05 NA NA NA hsa-miR-421 ETS1 0.941856334694081 6.12167297054077e-08 -0.888146453921594 7.30600721510989e-10 miRanda;mirMAP;miRNATAP -0.204100092132273 4.23645182774089e-07 NA NA NA hsa-miR-455-5p ETS1 -0.270546034117157 0.0581320703577731 -0.888146453921594 7.30600721510989e-10 MirTarget;PITA;miRanda;miRNATAP -0.234313961624189 2.69025876931775e-06 NA NA NA hsa-miR-501-5p ETS1 1.15231083477882 2.98906150004088e-10 -0.888146453921594 7.30600721510989e-10 mirMAP -0.10302951257088 0.00734880104767461 NA NA NA hsa-miR-502-5p ETS1 0.892373335336396 1.7122694518919e-06 -0.888146453921594 7.30600721510989e-10 miRNATAP -0.110285767636931 0.00447567568456658 NA NA NA hsa-miR-532-3p ETS1 0.297601533259956 0.014632205884815 -0.888146453921594 7.30600721510989e-10 MirTarget;PITA;miRNATAP -0.287398076993315 8.8786296594351e-07 NA NA NA hsa-miR-590-5p ETS1 -0.103355559980404 0.310027295317092 -0.888146453921594 7.30600721510989e-10 miRanda -0.359124442253989 3.41545113201445e-07 NA NA NA hsa-miR-660-5p ETS1 0.989755850734071 5.69930767464937e-14 -0.888146453921594 7.30600721510989e-10 MirTarget -0.254076650434129 1.2827423637958e-06 NA NA NA hsa-miR-769-5p ETS1 0.219661452072771 0.0333425465750576 -0.888146453921594 7.30600721510989e-10 miRNATAP -0.213050530713541 0.00233319206600267 NA NA NA hsa-miR-940 ETS1 0.453020092551484 0.0177054921651997 -0.888146453921594 7.30600721510989e-10 MirTarget;miRNATAP -0.152992991185501 6.8236118996806e-05 NA NA NA hsa-miR-148a-3p ETV5 -0.748702855596996 3.93313343865641e-07 -0.145389102256725 0.355370993767523 MirTarget;miRNATAP -0.296784259819511 4.1170913506311e-09 NA NA NA hsa-miR-148a-5p EXT1 -0.767626696027761 1.08359477494797e-06 -0.116219835522597 0.337006077868152 mirMAP -0.246459687127587 9.15194289581829e-12 NA NA NA hsa-miR-148a-3p F3 -0.748702855596996 3.93313343865641e-07 -1.77735272391257 4.53941856275069e-12 MirTarget -0.587483900043743 2.87917611994749e-12 NA NA NA hsa-miR-148a-5p FAM102B -0.767626696027761 1.08359477494797e-06 -0.162374897564143 0.256009972555516 MirTarget -0.291972658832942 8.18752432960357e-12 NA NA NA hsa-miR-148a-5p FAM117B -0.767626696027761 1.08359477494797e-06 0.103695795405027 0.442637591978479 MirTarget -0.283551721578898 1.89374903618426e-12 NA NA NA hsa-miR-148a-3p FAM160B2 -0.748702855596996 3.93313343865641e-07 0.170041130884332 0.0540544370833985 mirMAP -0.161281958630114 1.22626225985271e-08 NA NA NA hsa-miR-148a-3p FAM53B -0.748702855596996 3.93313343865641e-07 0.971989850032648 4.87327424473216e-17 mirMAP -0.286212044971369 6.7551492819291e-14 NA NA NA hsa-miR-148a-3p FBXL19 -0.748702855596996 3.93313343865641e-07 1.09129763767905 3.05430880690495e-25 miRNATAP -0.383651844314371 1.41544005302887e-29 NA NA NA hsa-miR-148a-5p FBXO41 -0.767626696027761 1.08359477494797e-06 0.395728773948549 0.102434434149993 mirMAP -0.451674718188294 5.82742001415051e-10 NA NA NA hsa-miR-148a-5p FERMT1 -0.767626696027761 1.08359477494797e-06 1.14528954642755 0.00602104982484306 MirTarget;miRNATAP -0.380227254166005 0.00299964306383305 NA NA NA hsa-miR-103a-3p FGF2 0.765568928457606 3.05497476509383e-12 -1.08625533231299 0.000324809942833161 miRNAWalker2_validate;MirTarget;miRNATAP -0.333696884446656 0.0118326533065286 NA NA NA hsa-miR-15b-3p FGF2 0.238105490431193 0.0997721500357416 -1.08625533231299 0.000324809942833161 mirMAP -0.499213807743807 9.41955107470528e-07 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 0.230566941413564 0.0824765001857479 -1.08625533231299 0.000324809942833161 MirTarget;miRNATAP -0.306809751282981 0.00622064491645458 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-2-3p FGF2 -0.0336420826463706 0.805158952566973 -1.08625533231299 0.000324809942833161 mirMAP -0.422467965590387 0.000103679884556575 NA NA NA hsa-miR-181a-5p FGF2 0.250113435902954 0.0551933249319293 -1.08625533231299 0.000324809942833161 mirMAP -0.406045352280239 0.000358497143826792 NA NA NA hsa-miR-181b-5p FGF2 0.488256489401108 0.00105321129419701 -1.08625533231299 0.000324809942833161 mirMAP -0.523910277677257 9.1015168945214e-08 NA NA NA hsa-miR-19b-1-5p FGF2 -0.277804782598538 0.0783067794722916 -1.08625533231299 0.000324809942833161 mirMAP -0.529151998934904 1.16181517704286e-08 NA NA NA hsa-miR-200b-3p FGF2 -1.29335788099229 0.000268623234305059 -1.08625533231299 0.000324809942833161 mirMAP -0.168899172593471 4.11351056555817e-05 NA NA NA hsa-miR-200c-3p FGF2 -0.104675615392797 0.716957669484981 -1.08625533231299 0.000324809942833161 mirMAP -0.156084549253076 0.00233819769179705 NA NA NA hsa-miR-20a-3p FGF2 -0.318177901603857 0.0467885456739855 -1.08625533231299 0.000324809942833161 mirMAP -0.492065243098747 8.09310422865092e-08 NA NA NA hsa-miR-21-3p FGF2 -0.484219378716006 0.00299941098417659 -1.08625533231299 0.000324809942833161 mirMAP -0.240197113439825 0.00811114129230132 NA NA NA hsa-miR-21-5p FGF2 1.51084295924322 1.54551622173259e-34 -1.08625533231299 0.000324809942833161 mirMAP -0.443381765546842 5.91228766084995e-05 NA NA NA hsa-miR-215-5p FGF2 -0.981544773246509 3.14452272477156e-05 -1.08625533231299 0.000324809942833161 miRNAWalker2_validate -0.153448795618752 0.0138240489461602 NA NA NA hsa-miR-217 FGF2 1.05797297540381 0.0401026692682422 -1.08625533231299 0.000324809942833161 miRanda -0.127490520581258 7.38698652450206e-06 NA NA NA hsa-miR-222-3p FGF2 1.08574156066353 1.76407192348131e-11 -1.08625533231299 0.000324809942833161 mirMAP -0.206975558906397 0.0212088626227192 NA NA NA hsa-miR-330-3p FGF2 -0.332364259424489 0.0316051913061459 -1.08625533231299 0.000324809942833161 mirMAP -0.238733647850468 0.0151404054794887 NA NA NA hsa-miR-335-3p FGF2 -0.275199247483111 0.106629165248783 -1.08625533231299 0.000324809942833161 mirMAP -0.405107692314837 2.67658505476485e-06 NA NA NA hsa-miR-338-5p FGF2 -0.221898432884726 0.252390988727086 -1.08625533231299 0.000324809942833161 mirMAP -0.277477917380717 0.000298421894309671 NA NA NA hsa-miR-429 FGF2 -1.40262535827285 6.93982219171912e-05 -1.08625533231299 0.000324809942833161 mirMAP -0.192074793475977 4.45604159403906e-06 NA NA NA hsa-miR-452-5p FGF2 1.91544498799508 1.81995982853313e-14 -1.08625533231299 0.000324809942833161 mirMAP -0.254292038125162 7.84361502048493e-06 NA NA NA hsa-miR-589-3p FGF2 1.16846704028095 5.88525574424201e-11 -1.08625533231299 0.000324809942833161 mirMAP -0.346323302130209 2.68946343007257e-05 NA NA NA hsa-miR-590-5p FGF2 -0.103355559980404 0.310027295317092 -1.08625533231299 0.000324809942833161 miRanda;mirMAP -0.300649640419796 0.0415702477858108 NA NA NA hsa-miR-92a-3p FGF2 0.212391012518195 0.134292268089997 -1.08625533231299 0.000324809942833161 miRNAWalker2_validate -0.635934402042256 6.72536311164143e-10 NA NA NA hsa-miR-93-3p FGF2 0.402821129107592 0.00131324842735588 -1.08625533231299 0.000324809942833161 mirMAP -0.437085459323848 0.000209985380897254 NA NA NA hsa-miR-100-5p FGFR3 -0.783576782126614 0.000219958772262677 0.189024805500786 0.340204942325551 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.269596147351536 1.27205852375091e-09 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-590-3p FGFR3 -0.473167498047808 1.76652934637227e-05 0.189024805500786 0.340204942325551 miRanda -0.178376084373127 0.0416868756939642 NA NA NA hsa-miR-99a-5p FGFR3 -1.51481656384839 3.93230057259529e-14 0.189024805500786 0.340204942325551 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.302096873169716 3.68370160731018e-11 23409016;24456664;23298836 Photofrin based photodynamic therapy and miR 99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo; Further photofrin based PDT followed by miR-99a transfection dramatically increased miR-99a expression and also increased apoptosis in glioblastoma cell cultures and drastically reduced tumor growth in athymic nude mice due to down regulation of fibroblast growth factor receptor 3 FGFR3 and PI3K/Akt signaling mechanisms leading to inhibition of cell proliferation and induction of molecular mechanisms of apoptosis;miR 99a promotes proliferation targeting FGFR3 in human epithelial ovarian cancer cells; Importantly fibroblast growth factor receptor 3 FGFR3 predicted to be one target gene of miR-99a using computational algorithms was higher in expression in EOC cells; Subsequently FGFR3 was proved to be direct target of miR-99a by dual luciferase assay; Furthermore overexpression of miR-99a dramatically suppressed expression level of FGFR3 at both mRNA and protein levels proving FGFR3 to be inversely correlated with miR-99a; Finally overexpression of miR-99a could significantly inhibit EOC cell proliferation in vitro by decreasing the expression of FGFR3 which also reduced the EOC cell growth after siRNA knockdown; Conclusively miR-99a expression was remarkably downregulated in serums tissues and cell and suppresses EOC cell proliferation by targeting FGFR3 suggesting miR-99a as a prospective prognosis marker and potential tumor suppressor for EOC therapeutics;The tumorigenic FGFR3 TACC3 gene fusion escapes miR 99a regulation in glioblastoma; The fusion caused by tandem duplication on 4p16.3 led to the loss of the 3'-UTR of FGFR3 blocking gene regulation of miR-99a and enhancing expression of the fusion gene ;worse prognosis; glioblastoma;ovarian cancer;glioblastoma hsa-miR-148a-5p FKBP1A -0.767626696027761 1.08359477494797e-06 0.493789459412955 4.84860703477717e-09 miRNATAP -0.151039952056557 4.90063430174896e-09 NA NA NA hsa-miR-148a-3p FLOT2 -0.748702855596996 3.93313343865641e-07 0.174241659619787 0.0839095721996099 MirTarget -0.135661337188965 3.25812696544883e-05 NA NA NA hsa-miR-148a-5p FLRT2 -0.767626696027761 1.08359477494797e-06 -2.1592326653748 8.94227258133224e-11 mirMAP -0.489394343351018 2.30322725986671e-06 NA NA NA hsa-miR-148a-5p FMN1 -0.767626696027761 1.08359477494797e-06 -0.641575890494061 0.0277147350428254 mirMAP -0.311382281526805 0.000481937467701825 NA NA NA hsa-miR-148a-3p FMNL3 -0.748702855596996 3.93313343865641e-07 0.665131482558671 1.67762417764945e-07 miRNATAP -0.454255007976079 2.93997652908655e-31 NA NA NA hsa-miR-148a-5p FMNL3 -0.767626696027761 1.08359477494797e-06 0.665131482558671 1.67762417764945e-07 mirMAP -0.348935163544933 2.11447240070397e-20 NA NA NA hsa-miR-148a-3p FOXF1 -0.748702855596996 3.93313343865641e-07 -1.93657438569129 8.48580930399672e-18 MirTarget -0.314860376896413 3.72189697847819e-05 NA NA NA hsa-miR-148a-3p FOXK1 -0.748702855596996 3.93313343865641e-07 1.204250755958 4.1435634806038e-25 mirMAP -0.278355247713312 1.45950739758757e-12 NA NA NA hsa-miR-148a-5p FOXK1 -0.767626696027761 1.08359477494797e-06 1.204250755958 4.1435634806038e-25 mirMAP -0.199010959312438 1.00158723513795e-07 NA NA NA hsa-miR-148a-3p FOXK2 -0.748702855596996 3.93313343865641e-07 0.559422556682597 5.5934596281655e-10 miRNATAP -0.122231023757654 4.16509173410562e-05 NA NA NA hsa-miR-148a-5p FRMD6 -0.767626696027761 1.08359477494797e-06 -1.21152640864769 5.47511255884304e-11 miRNATAP -0.265946601036678 3.72552484847375e-06 NA NA NA hsa-miR-148a-5p FSTL1 -0.767626696027761 1.08359477494797e-06 -0.53295806881748 0.00292082806371731 mirMAP -0.31412274620126 6.85701583572212e-09 NA NA NA hsa-miR-148a-5p FZD3 -0.767626696027761 1.08359477494797e-06 -0.431602727356764 0.0760494397449049 mirMAP -0.211739463838664 0.00451119062120206 NA NA NA hsa-miR-101-3p FZD6 -1.48176407980989 3.98950707385704e-31 0.589500198001939 0.00374127878510925 miRNAWalker2_validate;MirTarget -0.312670748498135 1.38907823475328e-05 NA NA NA hsa-miR-139-5p FZD6 -2.11299531796557 8.16407076415038e-28 0.589500198001939 0.00374127878510925 miRanda -0.171390807110702 0.00034847427750895 NA NA NA hsa-miR-194-5p FZD6 -0.292530160992458 0.0996141384876663 0.589500198001939 0.00374127878510925 MirTarget -0.265420163621645 1.75074747054336e-06 NA NA NA hsa-miR-455-5p FZD6 -0.270546034117157 0.0581320703577731 0.589500198001939 0.00374127878510925 miRanda -0.230555626016252 0.000940179578305785 NA NA NA hsa-miR-148a-5p GAB2 -0.767626696027761 1.08359477494797e-06 0.582469424043986 4.14162511103667e-06 mirMAP -0.150112192167145 0.000116928574414138 NA NA NA hsa-miR-148a-5p GALNT10 -0.767626696027761 1.08359477494797e-06 0.831350337705815 6.36030803570338e-11 mirMAP -0.23297090178249 2.8107741512709e-09 NA NA NA hsa-miR-148a-3p GAS1 -0.748702855596996 3.93313343865641e-07 -2.01123836877249 1.00269358999977e-12 miRNAWalker2_validate -0.446935540677881 1.98427341642504e-06 NA NA NA hsa-miR-148a-3p GDF6 -0.748702855596996 3.93313343865641e-07 -2.10139054692363 1.01669881798518e-11 miRNATAP -0.327974606729441 0.00151705432220982 NA NA NA hsa-miR-148a-5p GJA1 -0.767626696027761 1.08359477494797e-06 0.506352390170207 0.00155115110748353 MirTarget;miRNATAP -0.202529950380846 3.47863671567994e-05 NA NA NA hsa-miR-148a-3p GLIPR2 -0.748702855596996 3.93313343865641e-07 -0.261246364993241 0.126523092005897 MirTarget -0.572861369908527 5.79843097207256e-28 NA NA NA hsa-miR-148a-5p GPC4 -0.767626696027761 1.08359477494797e-06 -0.913560136947943 0.0100287848448375 mirMAP -0.875665240635459 8.04458688891508e-17 NA NA NA hsa-miR-148a-3p GPRC5A -0.748702855596996 3.93313343865641e-07 -1.98790398617405 1.71576224263651e-08 MirTarget -0.64837950530788 2.02612216438666e-08 NA NA NA hsa-miR-148a-5p GRIK4 -0.767626696027761 1.08359477494797e-06 1.21698116585755 0.000489990948437745 mirMAP -0.524896010475382 8.39415904497677e-07 NA NA NA hsa-miR-148a-5p GUCY2C -0.767626696027761 1.08359477494797e-06 1.46214408388786 0.00407269207566429 MirTarget -0.345617633775577 0.027555805200227 NA NA NA hsa-miR-148a-5p H2AFY2 -0.767626696027761 1.08359477494797e-06 0.0449885281277016 0.886493569646536 miRNATAP -0.401191057294493 2.86566084977667e-05 NA NA NA hsa-miR-148a-5p HAPLN1 -0.767626696027761 1.08359477494797e-06 1.33038232891219 0.000123661512782167 mirMAP -0.281737198487764 0.00849311457934196 NA NA NA hsa-miR-148a-3p HAS3 -0.748702855596996 3.93313343865641e-07 0.499425712466684 0.000692477830824529 miRNATAP -0.169268758647117 0.000440496808434031 NA NA NA hsa-miR-148a-5p HELLS -0.767626696027761 1.08359477494797e-06 2.62327787224869 1.35869467447747e-28 mirMAP -0.205649452725597 0.00818152736505431 NA NA NA hsa-miR-107 HIF1A 0.241662461253461 0.0170788899505389 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate;miRTarBase;miRanda -0.436710343430652 2.03313957855482e-10 NA NA NA hsa-miR-17-5p HIF1A 0.698861147045461 2.43854106455398e-05 -0.366176828296648 0.0111002186054683 miRTarBase;MirTarget;TargetScan -0.207486649592262 6.73419034465465e-07 NA NA NA hsa-miR-20a-5p HIF1A 0.854326758727003 5.04256669663285e-07 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate;miRTarBase;MirTarget -0.245558453559623 9.83134714947215e-10 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-33a-5p HIF1A -0.767474460958522 1.09948756118522e-05 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate -0.107227499920455 0.00730487730363833 NA NA NA hsa-miR-616-5p HIF1A 0.150569904638223 0.402836556304524 -0.366176828296648 0.0111002186054683 MirTarget -0.124976106072862 0.00144238259369066 NA NA NA hsa-miR-660-5p HIF1A 0.989755850734071 5.69930767464937e-14 -0.366176828296648 0.0111002186054683 MirTarget -0.249870386379118 1.21860559731773e-06 NA NA NA hsa-miR-93-5p HIF1A 1.39518349670953 2.84167728726712e-25 -0.366176828296648 0.0111002186054683 MirTarget -0.173769064325932 0.000425501783480084 NA NA NA hsa-miR-148a-5p HMGA2 -0.767626696027761 1.08359477494797e-06 1.11519648679255 0.015940340984894 mirMAP -0.657849544386419 3.03990369970668e-06 NA NA NA hsa-miR-148a-3p HOMER1 -0.748702855596996 3.93313343865641e-07 -0.0763641412081514 0.796151529043688 MirTarget -0.666575262467855 1.35873064627191e-12 NA NA NA hsa-miR-148a-3p HOXC8 -0.748702855596996 3.93313343865641e-07 0.89168315412305 0.00741079667695049 miRNAWalker2_validate;miRNATAP -0.316760862079704 0.00368044169533115 NA NA NA hsa-miR-148a-5p HUNK -0.767626696027761 1.08359477494797e-06 -0.720733679971585 0.0531352542804175 mirMAP -0.547651372829365 1.32886704884329e-06 NA NA NA hsa-miR-148a-5p ID4 -0.767626696027761 1.08359477494797e-06 -1.27298671386794 2.11782253912459e-06 MirTarget -0.580939422209125 8.00990887130119e-13 NA NA NA hsa-miR-148a-5p IFFO2 -0.767626696027761 1.08359477494797e-06 0.3561399548351 0.00984902835621805 mirMAP -0.168491187218459 6.32120631823824e-05 NA NA NA hsa-miR-148a-3p IGDCC4 -0.748702855596996 3.93313343865641e-07 1.73062068710294 1.15353341113415e-06 miRNATAP -1.10203964346989 5.8953450678023e-23 NA NA NA hsa-miR-148a-5p IGF1R -0.767626696027761 1.08359477494797e-06 -0.704819576268303 0.00353845530141102 mirMAP -0.626014741533492 1.69198276385715e-18 NA NA NA hsa-miR-148a-5p IGFBP5 -0.767626696027761 1.08359477494797e-06 -0.795485319301285 0.00081396472061437 mirMAP -0.369109800878485 3.40958746081664e-07 NA NA NA hsa-miR-125a-5p IKBKG -0.91219969372382 1.38256246489548e-07 0.660366120199928 1.71867865546723e-06 miRanda -0.219029418282295 9.51829321882113e-09 NA NA NA hsa-miR-143-3p IKBKG -0.584123869220553 0.000907217687997436 0.660366120199928 1.71867865546723e-06 mirMAP -0.169551761758995 9.09905571393035e-06 NA NA NA hsa-miR-200a-3p IKBKG -1.49949292595657 3.18410995256133e-05 0.660366120199928 1.71867865546723e-06 mirMAP -0.100439586597671 5.62621816828972e-08 NA NA NA hsa-miR-24-3p IKBKG -0.257825594021966 0.00689742600215061 0.660366120199928 1.71867865546723e-06 mirMAP -0.287544034512102 5.8686253015948e-05 NA NA NA hsa-miR-3065-3p IKBKG -1.04244468016704 4.60743424372577e-05 0.660366120199928 1.71867865546723e-06 mirMAP -0.115721435331344 9.61381024877344e-06 NA NA NA hsa-miR-320a IKBKG 0.325285936317332 0.0221415065838824 0.660366120199928 1.71867865546723e-06 mirMAP -0.182311319218153 0.000133876392194021 NA NA NA hsa-miR-320b IKBKG 0.0919652022571331 0.607981643616945 0.660366120199928 1.71867865546723e-06 mirMAP -0.132285547849802 0.000522961413620221 NA NA NA hsa-miR-330-3p IKBKG -0.332364259424489 0.0316051913061459 0.660366120199928 1.71867865546723e-06 mirMAP -0.111083773167518 0.0137533606676294 NA NA NA hsa-miR-335-5p IKBKG -1.61347836513558 1.62757083289711e-19 0.660366120199928 1.71867865546723e-06 mirMAP -0.273399124951207 9.32430291537739e-15 NA NA NA hsa-miR-338-5p IKBKG -0.221898432884726 0.252390988727086 0.660366120199928 1.71867865546723e-06 mirMAP -0.206675822417303 2.68501101428877e-09 NA NA NA hsa-miR-376c-3p IKBKG -1.78544013329054 1.82972185127691e-10 0.660366120199928 1.71867865546723e-06 mirMAP -0.14083607992738 1.85430800686914e-09 NA NA NA hsa-miR-542-3p IKBKG -1.31351015149842 3.64642423288576e-22 0.660366120199928 1.71867865546723e-06 mirMAP -0.292142688932618 4.40119371820177e-10 NA NA NA hsa-miR-148a-3p IL15 -0.748702855596996 3.93313343865641e-07 -0.299033597604689 0.133566104518099 MirTarget -0.360950562564519 1.84990625247238e-08 NA NA NA hsa-miR-148a-3p IL17RD -0.748702855596996 3.93313343865641e-07 -0.125343297177237 0.609800523271957 miRNATAP -0.82706589585261 2.60537883515387e-28 NA NA NA hsa-miR-148a-3p IQCE -0.748702855596996 3.93313343865641e-07 1.21246761004316 4.22270897620511e-25 mirMAP -0.303477931958815 1.30626379135067e-14 NA NA NA hsa-miR-148a-3p ITGA5 -0.748702855596996 3.93313343865641e-07 0.471634888877482 5.29697754708897e-05 miRNATAP -0.307894492928595 8.35158872292536e-17 NA NA NA hsa-miR-125b-2-3p ITGA6 -1.6609436107315 5.71534047969855e-18 1.33116884445099 5.73067512733422e-21 mirMAP -0.177305489469283 7.67219603417741e-07 NA NA NA hsa-miR-199a-3p ITGA6 -2.3279328685682 1.04468066198593e-17 1.33116884445099 5.73067512733422e-21 PITA -0.166829140227348 2.64008048809431e-11 NA NA NA hsa-miR-199b-3p ITGA6 -2.33226605401203 9.51887435273314e-18 1.33116884445099 5.73067512733422e-21 PITA -0.166957893782338 2.45787733398932e-11 NA NA NA hsa-miR-335-3p ITGA6 -0.275199247483111 0.106629165248783 1.33116884445099 5.73067512733422e-21 mirMAP -0.138340364120149 0.00114101751107001 NA NA NA hsa-miR-342-3p ITGA6 -0.319677314984262 0.0449813878317147 1.33116884445099 5.73067512733422e-21 miRanda -0.124580956342346 0.00625142354926915 NA NA NA hsa-miR-192-5p ITGAV -0.50188499512787 0.00344713341196035 0.42083458357731 0.00760476174317356 miRNAWalker2_validate;MirTarget -0.344370980466671 1.89013250176103e-15 NA NA NA hsa-miR-32-5p ITGAV 0.0806126674664016 0.548984992497432 0.42083458357731 0.00760476174317356 miRNAWalker2_validate;MirTarget;miRNATAP -0.274975166498264 1.42681810268729e-06 NA NA NA hsa-miR-328-3p ITGAV -0.547466865311955 6.8359574451572e-06 0.42083458357731 0.00760476174317356 MirTarget -0.132063082039302 0.0363785445433637 NA NA NA hsa-miR-33a-3p ITGAV -0.683025859637737 1.01106097756419e-05 0.42083458357731 0.00760476174317356 MirTarget -0.155984185219414 0.00158654023964867 NA NA NA hsa-miR-374a-5p ITGAV 0.016390363747302 0.869784217438621 0.42083458357731 0.00760476174317356 mirMAP -0.174068026833335 0.0257907946480254 NA NA NA hsa-miR-92a-3p ITGAV 0.212391012518195 0.134292268089997 0.42083458357731 0.00760476174317356 MirTarget;miRNATAP -0.257814482101981 1.80305424957411e-06 NA NA NA hsa-miR-148a-3p ITGB8 -0.748702855596996 3.93313343865641e-07 -2.87006066676904 1.87352126528694e-11 miRNATAP -1.14663315826581 1.03967657771964e-16 NA NA NA hsa-miR-106b-5p JAK1 0.648901865047099 8.24870862047885e-09 -0.491502741052473 2.21647945606145e-08 miRNAWalker2_validate;MirTarget -0.274241391983959 1.386588824919e-13 NA NA NA hsa-miR-128-3p JAK1 0.289735108018712 0.0114419474207889 -0.491502741052473 2.21647945606145e-08 miRNAWalker2_validate -0.109369528499963 0.00404231658945177 NA NA NA hsa-miR-17-5p JAK1 0.698861147045461 2.43854106455398e-05 -0.491502741052473 2.21647945606145e-08 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.268052325740918 3.25515675433912e-28 NA NA NA hsa-miR-20a-5p JAK1 0.854326758727003 5.04256669663285e-07 -0.491502741052473 2.21647945606145e-08 MirTarget -0.23386116447226 1.56734608485868e-22 NA NA NA hsa-miR-30d-5p JAK1 0.718283816348023 2.47422074061352e-08 -0.491502741052473 2.21647945606145e-08 MirTarget -0.145093822003298 1.12748945024431e-05 NA NA NA hsa-miR-455-5p JAK1 -0.270546034117157 0.0581320703577731 -0.491502741052473 2.21647945606145e-08 miRanda -0.167977882302863 2.26382130466332e-08 NA NA NA hsa-miR-93-5p JAK1 1.39518349670953 2.84167728726712e-25 -0.491502741052473 2.21647945606145e-08 MirTarget;miRNATAP -0.238027881672368 6.65509610107069e-16 NA NA NA hsa-miR-148a-5p JAM2 -0.767626696027761 1.08359477494797e-06 -0.411475049759854 0.068165395262772 miRNATAP -0.164991530674779 0.0171711534816758 NA NA NA hsa-miR-148a-3p KCTD2 -0.748702855596996 3.93313343865641e-07 0.444262357803045 9.18948608129488e-08 mirMAP -0.140951745613528 2.08242607078795e-07 NA NA NA hsa-miR-148a-3p KIAA0513 -0.748702855596996 3.93313343865641e-07 0.677391070221105 4.5635483547066e-07 mirMAP -0.253703395270591 6.57401063298589e-09 NA NA NA hsa-miR-148a-5p KIAA1257 -0.767626696027761 1.08359477494797e-06 0.430040484019483 0.109863886905169 mirMAP -0.219303667681486 0.00782480542839518 NA NA NA hsa-miR-148a-3p KIAA1324L -0.748702855596996 3.93313343865641e-07 -0.50219104365772 0.0775324724611569 MirTarget;miRNATAP -0.427112379558327 3.63673905587508e-06 NA NA NA hsa-miR-148a-5p KIAA1462 -0.767626696027761 1.08359477494797e-06 1.43292602496162 9.79261879524332e-18 mirMAP -0.263530656521326 6.00839739181876e-07 NA NA NA hsa-miR-148a-5p KIAA1524 -0.767626696027761 1.08359477494797e-06 2.26353290817275 2.75002324721032e-22 MirTarget -0.262273918756031 0.000485198197378955 NA NA NA hsa-miR-148a-3p KIAA1549 -0.748702855596996 3.93313343865641e-07 0.660027387081498 0.0355851637057295 miRNAWalker2_validate -0.332119877358287 0.00120295124376642 NA NA NA hsa-miR-148a-5p KIAA1614 -0.767626696027761 1.08359477494797e-06 1.19012149096204 4.91603849396984e-08 mirMAP -0.409064157449567 8.84057067959313e-10 NA NA NA hsa-miR-148a-3p KIAA1644 -0.748702855596996 3.93313343865641e-07 -1.81284684066633 3.233194276281e-09 mirMAP -0.610055069449491 1.16426577116176e-09 NA NA NA hsa-miR-148a-3p KIF14 -0.748702855596996 3.93313343865641e-07 2.98333269436721 7.27784939820496e-37 MirTarget -0.352344124898679 2.55851993740245e-05 NA NA NA hsa-miR-148a-3p KIF21B -0.748702855596996 3.93313343865641e-07 1.1784578803772 5.28752515379585e-07 mirMAP -0.282228303711302 0.000272557559842213 NA NA NA hsa-miR-148a-3p KIF26B -0.748702855596996 3.93313343865641e-07 0.149322876930793 0.640083141858917 mirMAP -0.839423184214391 6.45316185740642e-17 NA NA NA hsa-miR-148a-5p KIFC3 -0.767626696027761 1.08359477494797e-06 0.294637755084813 0.0071663162397598 MirTarget -0.227062035406099 4.3811221432194e-12 NA NA NA hsa-miR-148a-5p KIRREL -0.767626696027761 1.08359477494797e-06 -0.920556464539881 0.00842298893942037 mirMAP -0.492530773169914 3.75609411144328e-06 NA NA NA hsa-miR-148a-3p KLC2 -0.748702855596996 3.93313343865641e-07 1.16492926016379 3.19134150923749e-23 miRNATAP -0.397394995398343 2.12082762386537e-25 NA NA NA hsa-miR-148a-3p KLF4 -0.748702855596996 3.93313343865641e-07 -1.65022485340468 8.09789885316327e-13 MirTarget;miRNATAP -0.22838478886868 0.00318884817829108 NA NA NA hsa-miR-148a-3p KLHL17 -0.748702855596996 3.93313343865641e-07 1.05691261770448 1.98597989430383e-20 MirTarget -0.16415613709474 2.35704886125403e-05 NA NA NA hsa-miR-148a-3p KLHL18 -0.748702855596996 3.93313343865641e-07 0.143407270163824 0.0265548542763812 mirMAP;miRNATAP -0.100825219689263 1.21939637109394e-06 NA NA NA hsa-miR-148a-5p KLHL4 -0.767626696027761 1.08359477494797e-06 -1.08539693977576 1.31560067160153e-06 mirMAP -0.204635659827657 0.00326400132710906 NA NA NA hsa-miR-148a-3p KLHL6 -0.748702855596996 3.93313343865641e-07 -0.339592374400176 0.0756406505671127 mirMAP -0.359369362340502 5.01732126782505e-09 NA NA NA hsa-miR-148a-5p KLHL6 -0.767626696027761 1.08359477494797e-06 -0.339592374400176 0.0756406505671127 mirMAP -0.23949662754997 3.92925549183173e-05 NA NA NA hsa-miR-140-3p KRAS 0.546012239205329 4.84578261098777e-11 -0.338081744192936 0.00043842779003105 MirTarget -0.247198429138234 9.22756583574077e-06 NA NA NA hsa-miR-16-1-3p KRAS 0.392360028038559 0.00112481918108198 -0.338081744192936 0.00043842779003105 mirMAP -0.114704330599848 0.00330327136149234 NA NA NA hsa-miR-193a-3p KRAS -0.117675551589896 0.309391958208578 -0.338081744192936 0.00043842779003105 MirTarget;miRanda;miRNATAP -0.128182356310374 0.00170700856743147 NA NA NA hsa-miR-193b-3p KRAS -0.166697207281748 0.272022543069482 -0.338081744192936 0.00043842779003105 miRNAWalker2_validate;MirTarget;miRNATAP -0.120510531869791 9.78248377856047e-05 25905463 Deregulation of the MiR 193b KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer; Mechanistically KRAS was verified as a direct effector of miR-193b through which the AKT and ERK pathways were modulated and cell growth of PDAC cells was suppressed; Taken together our findings indicate that miR-193b-mediated deregulation of the KRAS axis is involved in pancreatic carcinogenesis and suggest that miR-193b could be a potentially effective target for PDAC therapy tumorigenesis pancreatic cancer hsa-miR-30d-3p KRAS -0.120562286038759 0.329549534782125 -0.338081744192936 0.00043842779003105 MirTarget;miRNATAP -0.132565215112955 0.000512493362671086 NA NA NA hsa-miR-532-5p KRAS 1.02729546510601 9.93318913966636e-16 -0.338081744192936 0.00043842779003105 MirTarget;PITA;miRNATAP -0.137739612561571 0.000100604507963156 NA NA NA hsa-miR-148a-3p KSR2 -0.748702855596996 3.93313343865641e-07 0.506902986173332 0.110760452022147 mirMAP -0.476743808874194 3.69345752464517e-06 NA NA NA hsa-miR-148a-5p KSR2 -0.767626696027761 1.08359477494797e-06 0.506902986173332 0.110760452022147 mirMAP -0.348470380741742 0.000333111282548724 NA NA NA hsa-miR-146b-5p LAMA2 0.419719546795449 0.0457375823220155 -2.25093797189139 1.13318229560757e-08 miRanda -0.200973106106506 0.0311052794529279 NA NA NA hsa-miR-324-5p LAMB3 0.372933276649782 0.00592280066108904 0.205469745450436 0.402537496980396 miRanda -0.210911510332022 0.017049035981626 NA NA NA hsa-miR-148a-3p LENG8 -0.748702855596996 3.93313343865641e-07 0.75934588482606 9.40854812638038e-12 miRNATAP -0.17903107934032 1.24127378758558e-06 NA NA NA hsa-miR-148a-3p LMX1B -0.748702855596996 3.93313343865641e-07 0.364650040807185 0.351279745807035 mirMAP -0.833948271652518 2.48999705809489e-11 NA NA NA hsa-miR-148a-3p LONRF2 -0.748702855596996 3.93313343865641e-07 -1.03606777199417 0.00951581549876641 mirMAP -0.681330104510286 1.38533515320194e-07 NA NA NA hsa-miR-148a-5p LPL -0.767626696027761 1.08359477494797e-06 2.28010324035066 5.5045312934226e-24 mirMAP -0.262767203253367 0.000323862275627769 NA NA NA hsa-miR-148a-3p LRFN1 -0.748702855596996 3.93313343865641e-07 0.250715581306462 0.275069133493013 miRNATAP -0.511549192387535 2.7107957688765e-12 NA NA NA hsa-miR-148a-3p LRRC8B -0.748702855596996 3.93313343865641e-07 -0.654336651065766 0.000402530838893617 mirMAP -0.436351948687831 1.51375647413546e-13 NA NA NA hsa-miR-148a-5p LTBP2 -0.767626696027761 1.08359477494797e-06 0.808067937950208 0.000768224069626524 mirMAP -0.652616775425854 2.63636990065311e-20 NA NA NA hsa-miR-148a-5p LXN -0.767626696027761 1.08359477494797e-06 -0.171841699411106 0.366134985040517 MirTarget -0.452232085359032 9.03735035053219e-16 NA NA NA hsa-miR-148a-3p MAF1 -0.748702855596996 3.93313343865641e-07 0.587254598885209 1.4790557878107e-07 MirTarget;miRNATAP -0.200491523719441 3.87334746762256e-08 NA NA NA hsa-miR-148a-3p MAFG -0.748702855596996 3.93313343865641e-07 1.20304222370093 2.42633916447559e-19 MirTarget -0.167941692314853 0.000226466679423781 NA NA NA hsa-miR-148a-5p MAP1B -0.767626696027761 1.08359477494797e-06 0.751522072716614 1.33167615372873e-05 mirMAP;miRNATAP -0.425973329120733 1.29368051402806e-16 NA NA NA hsa-miR-140-3p MAP2K1 0.546012239205329 4.84578261098777e-11 -1.22814648702538 4.27448032410174e-41 PITA -0.381987666476187 3.26697824928144e-11 NA NA NA hsa-miR-34a-5p MAP2K1 1.03694231790865 5.74864019540594e-14 -1.22814648702538 4.27448032410174e-41 miRNAWalker2_validate;miRTarBase -0.229470281840033 1.32655977381036e-11 NA NA NA hsa-miR-361-5p MAP2K1 0.233202959858696 0.00961572812255327 -1.22814648702538 4.27448032410174e-41 miRanda -0.180575442044722 0.00107072926955335 NA NA NA hsa-miR-501-5p MAP2K1 1.15231083477882 2.98906150004088e-10 -1.22814648702538 4.27448032410174e-41 PITA -0.144135390798289 3.07397683406163e-08 NA NA NA hsa-miR-148a-3p MAP7D2 -0.748702855596996 3.93313343865641e-07 0.763166018662374 0.0866664092768403 MirTarget -0.466762788951956 0.00132535874257167 NA NA NA hsa-miR-148a-3p MARCH3 -0.748702855596996 3.93313343865641e-07 0.616348863709913 0.0025556726558054 MirTarget;miRNATAP -0.624353117326105 9.30331919035579e-23 NA NA NA hsa-miR-148a-5p MARCKS -0.767626696027761 1.08359477494797e-06 0.47891030020215 0.00159784808861844 MirTarget -0.333048818283666 2.18744138867785e-13 NA NA NA hsa-miR-148a-3p MATN3 -0.748702855596996 3.93313343865641e-07 2.24574154450948 1.20068691324261e-08 MirTarget -0.571507102978337 1.13120648716878e-05 NA NA NA hsa-miR-148a-3p MBP -0.748702855596996 3.93313343865641e-07 -0.401034568218827 0.00152582531127159 mirMAP -0.101868769145895 0.0140733136781751 NA NA NA hsa-miR-19b-3p MECOM 0.601279551368824 0.00016685097085251 0.959512171082984 9.09579943703071e-08 miRNATAP -0.129331453668629 0.0196315279663432 NA NA NA hsa-miR-22-3p MECOM -0.628561621952407 1.33755558015523e-09 0.959512171082984 9.09579943703071e-08 miRNATAP -0.180980334358813 0.0330564397272789 NA NA NA hsa-miR-361-5p MECOM 0.233202959858696 0.00961572812255327 0.959512171082984 9.09579943703071e-08 miRanda -0.278956690972315 0.00517024358546618 NA NA NA hsa-miR-374a-5p MECOM 0.016390363747302 0.869784217438621 0.959512171082984 9.09579943703071e-08 mirMAP -0.37178528301155 3.21945126868006e-05 NA NA NA hsa-miR-374b-5p MECOM -0.307538028546424 0.0030079617545972 0.959512171082984 9.09579943703071e-08 mirMAP -0.372614882805562 1.35293538346028e-05 NA NA NA hsa-miR-455-5p MECOM -0.270546034117157 0.0581320703577731 0.959512171082984 9.09579943703071e-08 miRanda -0.34626889403173 1.80675931190258e-08 NA NA NA hsa-miR-148a-3p MECP2 -0.748702855596996 3.93313343865641e-07 0.263893569030019 0.000429500323071978 miRNATAP -0.107629546729185 9.50479455092943e-06 NA NA NA hsa-miR-148a-3p MGAT4A -0.748702855596996 3.93313343865641e-07 0.104155687943847 0.347191347682603 MirTarget;miRNATAP -0.189467335208124 1.05295218983964e-07 NA NA NA hsa-miR-148a-5p MGAT4A -0.767626696027761 1.08359477494797e-06 0.104155687943847 0.347191347682603 mirMAP -0.174382473981691 1.84571348597822e-07 NA NA NA hsa-miR-148a-5p MGAT5 -0.767626696027761 1.08359477494797e-06 -0.048940912253241 0.86560089431757 miRNATAP -0.308203502412277 0.000478737112922363 NA NA NA hsa-miR-148a-3p MITF -0.748702855596996 3.93313343865641e-07 -0.406319701896632 0.0146105141167573 miRNATAP -0.467580582447595 3.04864215131373e-19 20644734 miR 148 regulates Mitf in melanoma cells; Furthermore miR-148 was shown to affect Mitf mRNA expression in melanoma cells through a conserved binding site in the 3'UTR sequence of mouse and human Mitf; Our data show that miR-148 and miR-137 present an additional level of regulating Mitf expression in melanocytes and melanoma cells melanoma hsa-miR-148a-3p MLLT6 -0.748702855596996 3.93313343865641e-07 0.653121837157595 1.00755151884882e-10 mirMAP -0.162803763078442 1.0554539412223e-06 NA NA NA hsa-miR-148a-3p MMD -0.748702855596996 3.93313343865641e-07 -0.0416538737688885 0.789780769629193 miRNATAP -0.372734806931057 4.84148415492915e-14 NA NA NA hsa-miR-148a-3p MMP15 -0.748702855596996 3.93313343865641e-07 -0.201202119912763 0.130626873491951 MirTarget;miRNATAP -0.120782391393074 0.00539566749823154 NA NA NA hsa-miR-148a-3p MNT -0.748702855596996 3.93313343865641e-07 0.184227791568378 0.0189335590228023 MirTarget;miRNATAP -0.134672890349733 9.4698522376505e-08 NA NA NA hsa-miR-148a-3p MOSPD1 -0.748702855596996 3.93313343865641e-07 0.488835757295254 0.000448347658243513 MirTarget;miRNATAP -0.134050229300976 0.00334048594892656 NA NA NA hsa-miR-148a-3p MPP2 -0.748702855596996 3.93313343865641e-07 0.359448868876671 0.193649765772268 mirMAP -0.576663912966332 7.06024094033857e-11 NA NA NA hsa-miR-125a-3p MSH3 -0.841683158494395 3.51202687176603e-05 -0.161343786741238 0.0575589260293181 miRanda -0.118807690934592 4.43923977822084e-09 NA NA NA hsa-miR-92b-3p MSH3 0.220374930803974 0.296187538889092 -0.161343786741238 0.0575589260293181 miRNAWalker2_validate -0.140228793554641 1.74398308418954e-13 NA NA NA hsa-miR-148a-5p MSRB3 -0.767626696027761 1.08359477494797e-06 -0.120755130016823 0.51722938086688 mirMAP -0.424689898072553 1.64996966014875e-14 NA NA NA hsa-miR-148a-5p MUC6 -0.767626696027761 1.08359477494797e-06 -5.2847961136927 6.16142142575516e-23 mirMAP -0.547183173882445 0.00160509942451245 NA NA NA hsa-miR-148a-3p MXRA7 -0.748702855596996 3.93313343865641e-07 0.0792703555372567 0.610154190820347 mirMAP -0.327411438179438 4.10632025038244e-11 NA NA NA hsa-miR-148a-3p MYBL1 -0.748702855596996 3.93313343865641e-07 1.1480718167108 4.98869165631426e-13 miRNATAP -0.223597573663347 2.53522339869195e-05 NA NA NA hsa-miR-148a-3p MYO5A -0.748702855596996 3.93313343865641e-07 0.557773632662129 0.000490007069603743 mirMAP -0.345280552201393 1.79580634840643e-11 NA NA NA hsa-miR-148a-5p MYO5A -0.767626696027761 1.08359477494797e-06 0.557773632662129 0.000490007069603743 mirMAP -0.25188348373887 2.32800189798409e-07 NA NA NA hsa-miR-148a-3p NAP1L1 -0.748702855596996 3.93313343865641e-07 0.48873822323481 4.44413744556636e-06 MirTarget -0.222421584730968 9.79324697889936e-11 NA NA NA hsa-miR-148a-3p NAT14 -0.748702855596996 3.93313343865641e-07 0.762454549118796 2.23303909352019e-05 miRNATAP -0.456270487898184 1.74702579708855e-15 NA NA NA hsa-miR-148a-3p NAT8L -0.748702855596996 3.93313343865641e-07 1.21195978404762 0.000153977148692105 MirTarget -0.624254951064272 1.68451566801213e-09 NA NA NA hsa-miR-148a-5p NAV1 -0.767626696027761 1.08359477494797e-06 0.457357293208876 0.00149629098704196 mirMAP;miRNATAP -0.313666388194297 3.43289513117875e-13 NA NA NA hsa-miR-148a-3p NBEA -0.748702855596996 3.93313343865641e-07 -0.95438160847924 0.000354673661355781 miRNATAP -0.517605225217207 2.06161972192119e-09 NA NA NA hsa-miR-148a-3p NCAM1 -0.748702855596996 3.93313343865641e-07 -3.20651653818541 4.82483086836138e-22 miRNATAP -0.269720143732448 0.0186234539799905 NA NA NA hsa-miR-148a-5p NCAPG -0.767626696027761 1.08359477494797e-06 4.24419479702984 8.5720361723705e-56 MirTarget -0.249673069123279 0.00861585582673706 NA NA NA hsa-miR-148a-3p NDOR1 -0.748702855596996 3.93313343865641e-07 1.05020501516652 5.12624788472277e-23 mirMAP -0.198297115609242 4.09966479091354e-08 NA NA NA hsa-miR-148a-3p NEBL -0.748702855596996 3.93313343865641e-07 -1.60837717002858 3.41970971707568e-05 mirMAP -0.515068828584662 5.20804366302462e-05 NA NA NA hsa-miR-148a-5p NEBL -0.767626696027761 1.08359477494797e-06 -1.60837717002858 3.41970971707568e-05 mirMAP -0.306011788463992 0.0108428478455137 NA NA NA hsa-miR-148a-3p NEURL4 -0.748702855596996 3.93313343865641e-07 0.227746874329284 0.00320954632248109 MirTarget;miRNATAP -0.112466163069294 6.8940335334216e-06 NA NA NA hsa-miR-148a-3p NFAM1 -0.748702855596996 3.93313343865641e-07 -1.5126511002004 1.93686430698698e-15 mirMAP -0.282215369366512 1.02973421453975e-05 NA NA NA hsa-miR-148a-5p NFAM1 -0.767626696027761 1.08359477494797e-06 -1.5126511002004 1.93686430698698e-15 mirMAP -0.164713874209282 0.0064311168536198 NA NA NA hsa-miR-148a-5p NFASC -0.767626696027761 1.08359477494797e-06 -0.522066844629388 0.0155574931536179 mirMAP -0.196320559200648 0.00302241742612114 25971746 NF κB induces miR 148a to sustain TGF β/Smad signaling activation in glioblastoma glioblastoma hsa-miR-15a-5p NFKB1 0.349521211668244 0.000770735998804736 -0.538916955748098 1.42993670239858e-08 miRNAWalker2_validate -0.153048958379264 0.000730484492411411 NA NA NA hsa-miR-548j-5p NFKB1 0.251239647701947 0.171361975450222 -0.538916955748098 1.42993670239858e-08 MirTarget -0.106885227436574 4.88574003092244e-05 NA NA NA hsa-miR-92a-3p NFKB1 0.212391012518195 0.134292268089997 -0.538916955748098 1.42993670239858e-08 miRNAWalker2_validate -0.147016189975437 8.47280185007855e-06 NA NA NA hsa-miR-148a-3p NHS -0.748702855596996 3.93313343865641e-07 0.0267805163013115 0.897730201737297 MirTarget;miRNATAP -0.58530039907232 2.38805824257e-19 NA NA NA hsa-miR-148a-5p NIN -0.767626696027761 1.08359477494797e-06 0.65727987135705 1.81289405977022e-08 mirMAP -0.114490270764187 0.00160111024117423 NA NA NA hsa-miR-148a-5p NIPA1 -0.767626696027761 1.08359477494797e-06 0.168444864185214 0.195838446873758 mirMAP -0.231354152376985 3.52940421414911e-09 NA NA NA hsa-miR-146b-3p NOS2 -1.20799545896423 2.19859530890688e-09 1.34188199912716 2.31721049529452e-07 MirTarget;miRNATAP -0.178469037014934 0.00416937467719295 NA NA NA hsa-miR-148a-5p NOTCH2 -0.767626696027761 1.08359477494797e-06 -0.382079512558875 0.00411077346024402 MirTarget -0.124169741301974 0.0023627624116557 NA NA NA hsa-miR-148a-3p NOVA1 -0.748702855596996 3.93313343865641e-07 -0.237953091882935 0.490244872279506 miRNATAP -0.784526571402052 8.59261064718394e-13 NA NA NA hsa-miR-148a-5p NOVA1 -0.767626696027761 1.08359477494797e-06 -0.237953091882935 0.490244872279506 miRNATAP -0.605262342898915 5.79527824900682e-09 NA NA NA hsa-miR-148a-3p NPEPL1 -0.748702855596996 3.93313343865641e-07 1.0134980247578 2.1959859851927e-21 MirTarget -0.275426794015186 8.58260763868164e-15 NA NA NA hsa-miR-148a-3p NPTX1 -0.748702855596996 3.93313343865641e-07 0.929025880461533 0.00584289763512414 miRNATAP -1.16655047743286 9.17100827578766e-30 NA NA NA hsa-miR-148a-3p NR2C2AP -0.748702855596996 3.93313343865641e-07 1.32716879157984 4.32641725625968e-31 MirTarget -0.218700998017347 3.7715743430841e-08 NA NA NA hsa-miR-148a-3p NRARP -0.748702855596996 3.93313343865641e-07 0.806873954048561 5.97890763868229e-07 MirTarget -0.408607463172978 2.94880871586574e-15 NA NA NA hsa-let-7b-5p NRAS -0.959013717270803 5.95127281258643e-11 0.301156333096785 0.000285671613438218 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.105903409272711 8.57245668973746e-05 20607356 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells glioblastoma hsa-miR-126-5p NRAS -0.428561469405594 6.6035585844222e-05 0.301156333096785 0.000285671613438218 mirMAP -0.145651073417946 0.000106824688349933 NA NA NA hsa-miR-145-5p NRAS -1.4795885711477 6.47308361543414e-16 0.301156333096785 0.000285671613438218 miRNAWalker2_validate;MirTarget;miRNATAP -0.120395847533196 1.03194548202048e-08 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-22-3p NRAS -0.628561621952407 1.33755558015523e-09 0.301156333096785 0.000285671613438218 MirTarget;miRNATAP -0.287363482934569 1.84836871548684e-14 NA NA NA hsa-miR-29a-3p NRAS -0.856762511178136 4.65330336378459e-12 0.301156333096785 0.000285671613438218 miRNATAP -0.111209986118726 0.000497462508043792 NA NA NA hsa-miR-29b-3p NRAS -0.348885528720517 0.0121441341291285 0.301156333096785 0.000285671613438218 miRNATAP -0.163441778679427 1.31476396622707e-08 NA NA NA hsa-miR-29c-3p NRAS -1.4367517608807 1.61767774905781e-21 0.301156333096785 0.000285671613438218 miRNATAP -0.195416271463693 3.04370398757482e-15 NA NA NA hsa-miR-664a-3p NRAS 0.485807855553031 0.000732553249798598 0.301156333096785 0.000285671613438218 MirTarget -0.123577371649095 9.58480979576424e-06 NA NA NA hsa-miR-148a-5p NRCAM -0.767626696027761 1.08359477494797e-06 1.19678747151501 0.00935952256234585 MirTarget -0.469689243952241 0.000883662278041652 NA NA NA hsa-miR-148a-3p NRP1 -0.748702855596996 3.93313343865641e-07 -0.0892756788072155 0.498410902584577 miRNATAP -0.18925467975584 9.1215690162959e-06 26967387 Mechanistically miR-148a appears to suppress the extravasation process of cancer cells likely by targeting two genes WNT1 and NRP1 in a cell non-autonomous manner breast cancer hsa-miR-148a-5p NTRK2 -0.767626696027761 1.08359477494797e-06 -2.30467079336051 6.66762032408277e-09 mirMAP -0.636528653670575 2.11782031176256e-07 NA NA NA hsa-miR-148a-3p OBSCN -0.748702855596996 3.93313343865641e-07 0.486867072596689 0.143711952566939 mirMAP -0.963676081304784 1.74328515884929e-20 NA NA NA hsa-miR-148a-5p OPHN1 -0.767626696027761 1.08359477494797e-06 0.532607187807659 0.00456117838675496 mirMAP -0.135104439304088 0.0193679400967582 NA NA NA hsa-miR-148a-3p ORAI2 -0.748702855596996 3.93313343865641e-07 0.147939436354318 0.336648923993268 mirMAP -0.628934430358564 3.04155769826223e-44 NA NA NA hsa-miR-148a-3p OTX1 -0.748702855596996 3.93313343865641e-07 3.02229789234294 1.88083127727288e-19 miRNATAP -0.710081313126758 2.7674669266848e-10 NA NA NA hsa-miR-148a-3p PACS2 -0.748702855596996 3.93313343865641e-07 0.778484820044494 1.37066720672879e-21 mirMAP -0.232363228345673 5.01661787042785e-18 NA NA NA hsa-miR-148a-3p PAG1 -0.748702855596996 3.93313343865641e-07 -0.0641776217701535 0.737132600565642 MirTarget -0.299690578625903 1.21889656248684e-06 NA NA NA hsa-miR-148a-3p PAN3 -0.748702855596996 3.93313343865641e-07 0.0449402615838541 0.627403000327265 miRNAWalker2_validate -0.103849251615092 0.000540183980733424 NA NA NA hsa-miR-148a-5p PBX1 -0.767626696027761 1.08359477494797e-06 -1.3362034667203 5.80856733969378e-07 mirMAP -0.187540295527125 0.0241340482844625 NA NA NA hsa-miR-148a-5p PCGF3 -0.767626696027761 1.08359477494797e-06 0.167536921370584 0.0398744101142924 MirTarget -0.142435426443568 6.0824986968797e-09 NA NA NA hsa-miR-148a-5p PDE4C -0.767626696027761 1.08359477494797e-06 1.61079470439428 1.89349843122692e-14 mirMAP -0.203096417103891 0.00227417136735443 NA NA NA hsa-miR-148a-5p PDE4D -0.767626696027761 1.08359477494797e-06 -0.666934323578114 0.000685777052439917 mirMAP -0.222582061464763 0.000222045163447661 NA NA NA hsa-miR-148a-3p PDE5A -0.748702855596996 3.93313343865641e-07 0.186921756686946 0.309659365294452 MirTarget -0.553041668936523 3.21460058912989e-22 NA NA NA hsa-miR-148a-5p PDE5A -0.767626696027761 1.08359477494797e-06 0.186921756686946 0.309659365294452 mirMAP -0.510468566332558 1.72194996760841e-21 NA NA NA hsa-miR-148a-3p PEA15 -0.748702855596996 3.93313343865641e-07 1.12311402840601 1.26777023794476e-31 MirTarget -0.164965212390181 8.2875656209855e-07 NA NA NA hsa-miR-148a-5p PHTF2 -0.767626696027761 1.08359477494797e-06 0.479833616664147 1.04897601040811e-06 MirTarget;miRNATAP -0.178384487857337 2.4363465091123e-09 NA NA NA hsa-miR-342-3p PIAS1 -0.319677314984262 0.0449813878317147 0.14110668905439 0.111009722342972 miRanda -0.127221288569843 1.97391983714843e-06 NA NA NA hsa-miR-148a-3p PIK3IP1 -0.748702855596996 3.93313343865641e-07 0.504536960127542 0.00150104183804736 MirTarget -0.412399483927594 2.45708221476412e-16 NA NA NA hsa-miR-103a-3p PIK3R1 0.765568928457606 3.05497476509383e-12 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.187692597616198 0.00702590214654354 NA NA NA hsa-miR-106b-5p PIK3R1 0.648901865047099 8.24870862047885e-09 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.369244291882445 4.59379549667075e-08 NA NA NA hsa-miR-1301-3p PIK3R1 1.12156714169769 4.22404125385203e-10 -0.891953424131491 1.38465728969785e-08 MirTarget -0.26088137729301 3.97606431390706e-10 NA NA NA hsa-miR-132-3p PIK3R1 0.323796239695997 0.00272093067935091 -0.891953424131491 1.38465728969785e-08 MirTarget -0.517351445825174 2.17222827385203e-13 NA NA NA hsa-miR-15b-5p PIK3R1 0.230566941413564 0.0824765001857479 -0.891953424131491 1.38465728969785e-08 MirTarget -0.132325827339178 0.0249531550846148 NA NA NA hsa-miR-17-5p PIK3R1 0.698861147045461 2.43854106455398e-05 -0.891953424131491 1.38465728969785e-08 MirTarget;TargetScan;miRNATAP -0.213954808771155 3.8587060059728e-06 NA NA NA hsa-miR-185-5p PIK3R1 0.480006257154717 6.35758891340152e-07 -0.891953424131491 1.38465728969785e-08 miRNATAP -0.255181123475439 0.00153792085091181 NA NA NA hsa-miR-188-5p PIK3R1 1.11646899351496 9.56686958408598e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.178093775716465 5.33015486626271e-05 NA NA NA hsa-miR-200c-3p PIK3R1 -0.104675615392797 0.716957669484981 -0.891953424131491 1.38465728969785e-08 mirMAP -0.105107802462856 9.06963579759966e-05 NA NA NA hsa-miR-20a-5p PIK3R1 0.854326758727003 5.04256669663285e-07 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.137431012149634 0.00237710222818209 NA NA NA hsa-miR-21-5p PIK3R1 1.51084295924322 1.54551622173259e-34 -0.891953424131491 1.38465728969785e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.626634426633867 6.01244523464713e-31 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.288359631986802 0.100392159518997 -0.891953424131491 1.38465728969785e-08 MirTarget -0.258090192317157 3.95293509038579e-09 NA NA NA hsa-miR-221-3p PIK3R1 1.12244756358612 3.48370308238012e-13 -0.891953424131491 1.38465728969785e-08 MirTarget -0.217914846238424 7.87055620620445e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.08574156066353 1.76407192348131e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.256619417997498 3.41697791848384e-08 NA NA NA hsa-miR-324-3p PIK3R1 0.260348469146494 0.0506141704203545 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.281792149179102 1.26555231509763e-06 NA NA NA hsa-miR-330-3p PIK3R1 -0.332364259424489 0.0316051913061459 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.212492102885122 3.44445995574159e-05 NA NA NA hsa-miR-338-5p PIK3R1 -0.221898432884726 0.252390988727086 -0.891953424131491 1.38465728969785e-08 PITA -0.143685656767977 0.000366657184559181 NA NA NA hsa-miR-409-3p PIK3R1 -0.499649792570937 0.0526751181520117 -0.891953424131491 1.38465728969785e-08 mirMAP -0.110448878014769 0.000237041711390918 NA NA NA hsa-miR-493-5p PIK3R1 -0.198321662045422 0.502870277689198 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.103739426368655 7.76271840065789e-05 NA NA NA hsa-miR-582-5p PIK3R1 -0.680189083316822 0.00103755166534107 -0.891953424131491 1.38465728969785e-08 mirMAP -0.138461163257927 0.00021364752999012 NA NA NA hsa-miR-589-3p PIK3R1 1.16846704028095 5.88525574424201e-11 -0.891953424131491 1.38465728969785e-08 mirMAP -0.21021578613876 1.13421126603334e-06 NA NA NA hsa-miR-590-5p PIK3R1 -0.103355559980404 0.310027295317092 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRanda;miRNATAP -0.299776876388425 9.9413226282672e-05 NA NA NA hsa-miR-629-3p PIK3R1 -0.315338123880353 0.119091248294946 -0.891953424131491 1.38465728969785e-08 MirTarget -0.182940394280375 3.19896248240917e-06 NA NA NA hsa-miR-93-5p PIK3R1 1.39518349670953 2.84167728726712e-25 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.319783065556515 2.89613370212511e-09 NA NA NA hsa-miR-148a-3p PITPNM3 -0.748702855596996 3.93313343865641e-07 -3.87084899319612 7.38035528475542e-40 mirMAP -0.339199491738163 0.00130873355554756 NA NA NA hsa-miR-148a-5p PLA2R1 -0.767626696027761 1.08359477494797e-06 -2.07756523384901 1.3460586411591e-12 mirMAP -0.521513336442267 1.00259551079527e-08 NA NA NA hsa-miR-148a-3p PLEKHB2 -0.748702855596996 3.93313343865641e-07 0.00560086814314076 0.957822592701461 MirTarget -0.38563730310529 6.3296530559203e-34 NA NA NA hsa-let-7b-5p PLK1 -0.959013717270803 5.95127281258643e-11 3.58200503456178 1.01936996392609e-41 miRNAWalker2_validate -0.508374715415364 7.45675351637923e-08 NA NA NA hsa-miR-100-5p PLK1 -0.783576782126614 0.000219958772262677 3.58200503456178 1.01936996392609e-41 miRNAWalker2_validate;miRTarBase -0.609428308452059 1.35398975085084e-21 23842624;23151088;22246341;25537513;22120675;21636267 In HCC tissues miR-100 expression was inversely correlated with the expression of plk1 protein r = -0.418; P = 0.029; Therefore downregulation of miR-100 was correlated with progressive pathological feature and poor prognosis in HCC patients and miR-100 could function as a tumor suppressor by targeting plk1;MicroRNA 100 is a potential molecular marker of non small cell lung cancer and functions as a tumor suppressor by targeting polo like kinase 1; By using microRNA miR target prediction algorithms we identified miR-100 that might potentially bind the 3'-untranslated region of PLK1 transcripts; The purpose of this study was to investigate the roles of miR-100 and its association with PLK1 in NSCLC development; Finally the effects of miR-100 expression on growth apoptosis and cell cycle of NSCLC cells by posttranscriptionally regulating PLK1 expression were determined; Meanwhile miR-100 mimics could significantly inhibit PLK1 mRNA and protein expression and reduce the luciferase activity of a PLK1 3' untranslated region-based reporter construct in A549 cells; Furthermore small interfering RNA siRNA-mediated PLK1 downregulation could mimic the effects of miR-100 mimics while PLK1 overexpression could partially rescue the phenotypical changes of NSCLC cells induced by miR-100 mimics; Our findings indicate that low miR-100 may be a poor prognostic factor for NSCLC patients and functions as a tumor suppressor by posttranscriptionally regulating PLK1 expression;Together these results suggest that low miR-100 expression may be an independent poor prognostic factor and miR-100 can function as a tumor suppressor by targeting PLK1 in human EOCs;Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 Plk1 down-regulation;MiR 100 resensitizes docetaxel resistant human lung adenocarcinoma cells SPC A1 to docetaxel by targeting Plk1; Knock-down of Plk1 which was a direct target of miR-100 yielded similar effects as that of ectopic miR-100 expression; The inverse correlation between miR-100 and Plk1 expression was also detected in nude mice SPC-A1/DTX tumor xenografts and clinical lung adenocarcinoma tissues and was proved to be related with the in vivo response to docetaxel; Thus our results suggested that down-regulation of miR-100 could lead to Plk1 over-expression and eventually to docetaxel chemoresistance of human lung adenocarcinoma;Reduced miR 100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein; Through modulating miR-100 expression using miR-100 inhibitor or mimic in vitro cell growth cycle and apoptosis were tested separately by MTT or flow cytometry and meanwhile Polo-like kinase1 PLK1 mRNA and protein expressions were detected by qRT-PCR and immunoblotting; The expression of PLK1 in 125 cervical tissues was also examined by immunohistochemical staining and the correlation between miR-100 and PLK1 expression in the same tissues was analysed; The modulation of miR-100 expression remarkably influenced cell proliferation cycle and apoptosis as well as the level of PLK1 protein but not mRNA in vitro experiments; PLK1 expression was negatively correlated with miR-100 expression in CIN3 and cervical cancer tissues; The reduced miR-100 expression participates in the development of cervical cancer at least partly through loss of inhibition to target gene PLK1 which probably occurs in a relative late phase of carcinogenesis progression;worse prognosis;;;;drug resistance;tumorigenesis liver cancer;lung squamous cell cancer;ovarian cancer;breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-486-5p PLK1 -1.77766890600022 2.9071717929922e-14 3.58200503456178 1.01936996392609e-41 miRanda -0.373122790226321 1.30117161322891e-10 NA NA NA hsa-miR-505-5p PLK1 -0.768282569967001 1.14662846595407e-05 3.58200503456178 1.01936996392609e-41 MirTarget -0.372253566265304 3.64975232604557e-06 NA NA NA hsa-miR-874-3p PLK1 -1.07043026298634 2.09564226589678e-07 3.58200503456178 1.01936996392609e-41 miRNAWalker2_validate -0.236755899629093 0.000522664320516165 NA NA NA hsa-miR-148a-3p PLXDC1 -0.748702855596996 3.93313343865641e-07 2.83957658613902 7.43247270561304e-40 mirMAP -0.883939730974154 2.16067872112889e-35 NA NA NA hsa-miR-148a-5p PLXNA2 -0.767626696027761 1.08359477494797e-06 0.670712916849495 3.85732284396182e-10 MirTarget;miRNATAP -0.118800773119581 0.000370534118159568 NA NA NA hsa-miR-148a-5p PNMA2 -0.767626696027761 1.08359477494797e-06 -1.85731298394428 7.34390157410046e-11 mirMAP -0.439748512660009 6.88709397980585e-07 NA NA NA hsa-miR-148a-3p PODXL -0.748702855596996 3.93313343865641e-07 1.44094860371079 1.88695975215765e-18 MirTarget -0.369390838413584 1.61834113480849e-11 NA NA NA hsa-miR-148a-3p POFUT2 -0.748702855596996 3.93313343865641e-07 0.257896779627181 0.00304062880467066 mirMAP -0.123524909535533 1.20021947046028e-05 NA NA NA hsa-miR-148a-3p PPARD -0.748702855596996 3.93313343865641e-07 0.429452867716368 0.000219062523065951 mirMAP -0.204207537151173 5.78289748261195e-08 NA NA NA hsa-miR-148a-5p PPFIBP1 -0.767626696027761 1.08359477494797e-06 -0.744896314834953 1.63767150832481e-10 MirTarget -0.164786853599679 5.2209617030806e-06 NA NA NA hsa-miR-148a-3p PPP1R12A -0.748702855596996 3.93313343865641e-07 0.0309603223785082 0.720960796133803 MirTarget;miRNATAP -0.102194619282546 0.000270364516263776 NA NA NA hsa-miR-148a-3p PPP1R9A -0.748702855596996 3.93313343865641e-07 -0.189630957451167 0.529029203320251 MirTarget -0.382420008575662 9.31566121697617e-05 NA NA NA hsa-miR-148a-3p PQLC3 -0.748702855596996 3.93313343865641e-07 -0.441550833103361 0.00124871420128405 MirTarget -0.227416925597569 2.92661541481649e-07 NA NA NA hsa-miR-148a-3p PRICKLE2 -0.748702855596996 3.93313343865641e-07 -1.36375835552812 1.67599789165395e-08 MirTarget;miRNATAP -0.361824889511995 5.66694348602003e-06 NA NA NA hsa-miR-148a-5p PRICKLE2 -0.767626696027761 1.08359477494797e-06 -1.36375835552812 1.67599789165395e-08 mirMAP -0.346057768362087 3.65630739339723e-06 NA NA NA hsa-miR-194-5p PRKCB -0.292530160992458 0.0996141384876663 -1.62067363753233 3.76201992658756e-13 miRNATAP -0.310861421038956 6.51903986219064e-07 NA NA NA hsa-miR-23b-3p PRKCB -0.530561587109023 5.43807206823652e-07 -1.62067363753233 3.76201992658756e-13 mirMAP -0.286204121948097 0.00657996649038471 NA NA NA hsa-miR-30d-5p PRKCB 0.718283816348023 2.47422074061352e-08 -1.62067363753233 3.76201992658756e-13 mirMAP -0.362125630736335 2.22146697946039e-05 NA NA NA hsa-miR-340-5p PRKCB -0.00477614531381576 0.968502722773791 -1.62067363753233 3.76201992658756e-13 mirMAP -0.225497683155663 0.0158024495898231 NA NA NA hsa-miR-361-5p PRKCB 0.233202959858696 0.00961572812255327 -1.62067363753233 3.76201992658756e-13 MirTarget;miRanda;miRNATAP -0.424918272347972 0.000711090604030861 NA NA NA hsa-miR-589-3p PRKCB 1.16846704028095 5.88525574424201e-11 -1.62067363753233 3.76201992658756e-13 mirMAP -0.228692909978861 0.000252673885842927 NA NA NA hsa-miR-589-5p PRKCB 1.18593770505086 1.01781241960531e-22 -1.62067363753233 3.76201992658756e-13 mirMAP -0.552773953594914 1.64276000301029e-10 NA NA NA hsa-miR-616-5p PRKCB 0.150569904638223 0.402836556304524 -1.62067363753233 3.76201992658756e-13 mirMAP -0.245704989615516 7.89898683278172e-05 NA NA NA hsa-miR-664a-3p PRKCB 0.485807855553031 0.000732553249798598 -1.62067363753233 3.76201992658756e-13 mirMAP -0.348212449855556 6.35284546408206e-06 NA NA NA hsa-miR-148a-5p PRKG1 -0.767626696027761 1.08359477494797e-06 -1.38853534989461 1.21422425786253e-07 mirMAP -0.279290392749617 0.000605187259153221 NA NA NA hsa-miR-148a-3p PRKX -0.748702855596996 3.93313343865641e-07 -0.240211607134995 0.240371070351319 MirTarget -0.590431480469924 2.08013051455884e-20 NA NA NA hsa-miR-148a-3p PRNP -0.748702855596996 3.93313343865641e-07 -1.31457732397415 1.33903555838973e-11 miRNAWalker2_validate;MirTarget -0.397460387082465 5.03565447558832e-10 NA NA NA hsa-miR-148a-3p PRR15 -0.748702855596996 3.93313343865641e-07 0.490966715538301 0.252618237144631 MirTarget -0.37711038705465 0.00714647584683602 NA NA NA hsa-miR-148a-5p PRTG -0.767626696027761 1.08359477494797e-06 -0.143683250081982 0.629800212088174 mirMAP -0.358601331247563 7.8418327890293e-05 NA NA NA hsa-miR-148a-3p PTPN14 -0.748702855596996 3.93313343865641e-07 0.635943426312836 0.000736881269593778 MirTarget;miRNATAP -0.430598688156951 9.08169553450041e-13 NA NA NA hsa-miR-148a-3p PTPRM -0.748702855596996 3.93313343865641e-07 0.0121830472151929 0.941670599603893 miRNATAP -0.257137605577313 1.74355883677486e-06 NA NA NA hsa-miR-148a-3p RAB10 -0.748702855596996 3.93313343865641e-07 0.283852356286084 7.31286137720053e-05 miRNAWalker2_validate -0.101607342652178 1.24328558037831e-05 NA NA NA hsa-miR-148a-3p RAB34 -0.748702855596996 3.93313343865641e-07 0.412870987704762 0.126202873299987 miRNAWalker2_validate;MirTarget;miRNATAP -0.797089078971911 2.39755456296972e-21 NA NA NA hsa-miR-148a-3p RAB35 -0.748702855596996 3.93313343865641e-07 0.223741416752273 0.000176271000804346 miRNATAP -0.103218271982733 7.43644180741036e-08 NA NA NA hsa-miR-148a-3p RAB6B -0.748702855596996 3.93313343865641e-07 1.14011669130437 2.23537791600293e-14 mirMAP -0.580164632188529 3.02823853653868e-36 NA NA NA hsa-miR-148a-5p RAB8B -0.767626696027761 1.08359477494797e-06 -0.221321521910201 0.0455526239538757 MirTarget;miRNATAP -0.12884507602876 0.000133163741597714 NA NA NA hsa-miR-19b-1-5p RALBP1 -0.277804782598538 0.0783067794722916 0.1698024329452 0.0449773531520714 mirMAP -0.107718420080393 3.35490340732313e-05 NA NA NA hsa-miR-148a-3p RALGPS1 -0.748702855596996 3.93313343865641e-07 0.376167916836608 0.081230746695397 mirMAP -0.16344418084918 0.0205836280387605 NA NA NA hsa-miR-148a-3p RANGAP1 -0.748702855596996 3.93313343865641e-07 0.368298574723631 0.00096323372819063 MirTarget -0.276509616318188 5.75616246983203e-15 NA NA NA hsa-miR-148a-5p RAP2A -0.767626696027761 1.08359477494797e-06 0.860149264838682 6.2979490616234e-12 mirMAP -0.131398199766351 0.000809454654531407 NA NA NA hsa-miR-148a-5p RAP2B -0.767626696027761 1.08359477494797e-06 0.0346031297557046 0.72839574434053 mirMAP -0.215141254273837 3.5723018566129e-13 NA NA NA hsa-miR-148a-5p RAPGEF5 -0.767626696027761 1.08359477494797e-06 -0.422807580779549 0.0037816955397449 mirMAP -0.287010528373387 6.37631922430446e-11 NA NA NA hsa-miR-146b-5p RARA 0.419719546795449 0.0457375823220155 0.26381183745838 0.00504882339445867 miRanda -0.113842988881595 1.2506902289011e-07 NA NA NA hsa-miR-148a-5p RASAL2 -0.767626696027761 1.08359477494797e-06 0.540621829902408 6.96559685302098e-05 mirMAP -0.141560911902939 0.000713336309653822 NA NA NA hsa-miR-148a-5p RASD2 -0.767626696027761 1.08359477494797e-06 2.400731696963 9.88874890802875e-33 mirMAP -0.439206443494633 1.95410385647646e-11 NA NA NA hsa-miR-148a-3p RASGRP1 -0.748702855596996 3.93313343865641e-07 -0.453717444218552 0.0529724316830882 MirTarget -0.453369512761064 1.78337663608658e-09 NA NA NA hsa-miR-148a-5p RASSF2 -0.767626696027761 1.08359477494797e-06 -0.691373209584495 1.83971460491871e-05 mirMAP -0.276888908135697 1.79681699327869e-08 NA NA NA hsa-miR-107 RASSF5 0.241662461253461 0.0170788899505389 -0.908227788377981 1.02390034106228e-08 PITA;miRanda;miRNATAP -0.284285927003021 0.000267803442305389 NA NA NA hsa-miR-421 RASSF5 0.941856334694081 6.12167297054077e-08 -0.908227788377981 1.02390034106228e-08 miRanda -0.134754778124398 0.00257128215281031 NA NA NA hsa-miR-532-5p RASSF5 1.02729546510601 9.93318913966636e-16 -0.908227788377981 1.02390034106228e-08 PITA;miRNATAP -0.217078156594971 0.000253741557038178 NA NA NA hsa-miR-148a-3p RASSF8 -0.748702855596996 3.93313343865641e-07 -0.720252468942172 0.000203633435082961 miRNAWalker2_validate;miRNATAP -0.252322899887963 6.96701184447254e-05 NA NA NA hsa-miR-148a-5p RBMS3 -0.767626696027761 1.08359477494797e-06 -1.89502188938102 2.39783861807597e-18 mirMAP -0.157236581334115 0.0236892689096956 NA NA NA hsa-miR-148a-5p RCN2 -0.767626696027761 1.08359477494797e-06 0.702225807365378 7.57876878361327e-13 MirTarget -0.101364822673593 0.000976330725902433 NA NA NA hsa-miR-148a-3p RGMA -0.748702855596996 3.93313343865641e-07 1.61034636670118 7.04556214896046e-13 miRNATAP -0.400326990300846 7.66740132539719e-08 NA NA NA hsa-miR-148a-5p RGS5 -0.767626696027761 1.08359477494797e-06 1.13782777301258 6.35983871996091e-09 mirMAP -0.251469549329447 3.53145945729302e-05 NA NA NA hsa-miR-148a-5p RIMKLB -0.767626696027761 1.08359477494797e-06 -0.389370791281358 0.0331706644700425 MirTarget -0.25396169139073 4.95996470932808e-06 NA NA NA hsa-miR-148a-5p RND3 -0.767626696027761 1.08359477494797e-06 -2.63829715019045 8.05722959113031e-42 miRNATAP -0.144133303752278 0.0297569216315857 NA NA NA hsa-miR-148a-3p RNF44 -0.748702855596996 3.93313343865641e-07 0.663587868143992 1.70848468031349e-11 miRNATAP -0.205949484265224 1.81870928982656e-10 NA NA NA hsa-miR-148a-3p ROBO1 -0.748702855596996 3.93313343865641e-07 2.32143722202073 1.044638687882e-16 MirTarget;miRNATAP -0.420616800754574 8.25510016639746e-06 NA NA NA hsa-miR-148a-3p ROBO2 -0.748702855596996 3.93313343865641e-07 -1.20081293982521 0.00234813022306189 miRNATAP -0.266203176462404 0.0402513644855282 NA NA NA hsa-miR-324-5p ROCK1 0.372933276649782 0.00592280066108904 -0.264366618624451 0.00575875249305368 MirTarget;PITA;miRanda -0.132464043588386 0.000113488217308036 NA NA NA hsa-miR-17-5p ROCK2 0.698861147045461 2.43854106455398e-05 -0.343723141838983 0.0978147147700846 TargetScan -0.230848684676223 0.000132737616833034 NA NA NA hsa-miR-148a-5p RPIA -0.767626696027761 1.08359477494797e-06 0.596191356011587 2.32659407207361e-14 miRNATAP -0.102130710046353 2.99530494309909e-05 NA NA NA hsa-miR-148a-5p RTKN2 -0.767626696027761 1.08359477494797e-06 2.57925113894623 4.76198655776531e-18 MirTarget;mirMAP -0.339187463023267 0.000355369807841797 NA NA NA hsa-miR-148a-3p RUNX2 -0.748702855596996 3.93313343865641e-07 -0.630390083285145 0.00682374266364812 miRNATAP -0.611751537093558 9.56180468519476e-17 NA NA NA hsa-miR-148a-5p RYR2 -0.767626696027761 1.08359477494797e-06 0.156714845003288 0.676631480041829 mirMAP -0.296504233407415 0.00998704725234469 NA NA NA hsa-miR-148a-3p SACS -0.748702855596996 3.93313343865641e-07 0.236568458255628 0.160647331666559 MirTarget -0.235342582834692 1.67486040913103e-05 NA NA NA hsa-miR-148a-3p SCRN1 -0.748702855596996 3.93313343865641e-07 -0.166351597402062 0.455235320666996 mirMAP -0.565993533684603 7.92544326060182e-16 25399950 A genetic variant of miR 148a binding site in the SCRN1 3' UTR is associated with susceptibility and prognosis of gastric cancer; Using bioinformatics tools we selected two SNPs SCRN1 rs6976789 and PDYN rs2235749 located in miR-148a target sites worse prognosis gastric cancer hsa-miR-148a-3p SDK2 -0.748702855596996 3.93313343865641e-07 -0.809681459593403 0.027508642080261 mirMAP -0.283099945212776 0.018670514896433 NA NA NA hsa-miR-148a-3p SEPT9 -0.748702855596996 3.93313343865641e-07 0.491611991206742 1.43369490340499e-09 mirMAP -0.217299710958597 5.96744758598083e-17 NA NA NA hsa-miR-148a-3p SERPINE1 -0.748702855596996 3.93313343865641e-07 -2.5626204615753 1.45202766560285e-19 miRNATAP -0.208585842910118 0.0317546494376279 NA NA NA hsa-miR-148a-5p SERPINE1 -0.767626696027761 1.08359477494797e-06 -2.5626204615753 1.45202766560285e-19 miRNATAP -0.260590457035894 0.00415058434081855 NA NA NA hsa-miR-148a-3p SESTD1 -0.748702855596996 3.93313343865641e-07 0.726908919315734 4.26585328930009e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.109379528086166 0.00785482875672258 NA NA NA hsa-miR-148a-5p SESTD1 -0.767626696027761 1.08359477494797e-06 0.726908919315734 4.26585328930009e-09 MirTarget -0.161265787147597 2.61106837361635e-05 NA NA NA hsa-miR-148a-5p SFMBT2 -0.767626696027761 1.08359477494797e-06 -0.653813685456887 0.0100525670943711 mirMAP -0.339074658549011 1.21140276006596e-05 NA NA NA hsa-miR-148a-5p SGCD -0.767626696027761 1.08359477494797e-06 -2.19675212080742 3.14480928648648e-10 mirMAP -0.311010361789749 0.0044610667733004 NA NA NA hsa-miR-148a-5p SGIP1 -0.767626696027761 1.08359477494797e-06 0.504143685723322 0.057817349628702 MirTarget -0.38242342254378 2.1974785302845e-06 NA NA NA hsa-miR-148a-5p SH3PXD2A -0.767626696027761 1.08359477494797e-06 0.416720664438486 0.000333370925413981 mirMAP -0.140961212404776 7.37749076329884e-05 NA NA NA hsa-miR-148a-3p SHC3 -0.748702855596996 3.93313343865641e-07 1.52510778944018 2.16327808412124e-07 MirTarget -0.266138626489331 0.00635514525014243 NA NA NA hsa-miR-148a-3p SIX4 -0.748702855596996 3.93313343865641e-07 2.61579593202535 2.3706138390953e-15 miRNATAP -0.567991524754382 2.80120759528324e-07 NA NA NA hsa-miR-148a-5p SIX4 -0.767626696027761 1.08359477494797e-06 2.61579593202535 2.3706138390953e-15 miRNATAP -0.484153220151745 3.24547124419975e-06 NA NA NA hsa-miR-148a-3p SLC16A6 -0.748702855596996 3.93313343865641e-07 -0.236488661429015 0.313225012355655 MirTarget;miRNATAP -0.276157865502067 0.00029453291851848 NA NA NA hsa-miR-148a-5p SLC16A9 -0.767626696027761 1.08359477494797e-06 -1.06090990279424 0.0194477008756128 MirTarget -0.552795126039945 6.76199443760409e-05 NA NA NA hsa-miR-148a-5p SLC22A15 -0.767626696027761 1.08359477494797e-06 1.05635935807366 0.00201382112271283 MirTarget -0.679518429474299 4.3175098685829e-11 NA NA NA hsa-miR-148a-3p SLC24A3 -0.748702855596996 3.93313343865641e-07 -1.47084747826355 6.82498530848671e-06 MirTarget;miRNATAP -0.89028739568033 1.00504027954793e-17 NA NA NA hsa-miR-148a-5p SLC26A2 -0.767626696027761 1.08359477494797e-06 1.09398018681738 4.62078215884211e-18 mirMAP -0.194173224024711 1.1638321249351e-06 NA NA NA hsa-miR-148a-3p SLC2A1 -0.748702855596996 3.93313343865641e-07 0.341472370166429 0.158776644395418 MirTarget;miRNATAP -0.348562751036544 9.14649062361368e-06 NA NA NA hsa-miR-148a-3p SLC2A3 -0.748702855596996 3.93313343865641e-07 -1.04127632515242 1.14147654600336e-07 miRNAWalker2_validate -0.190614379961144 0.00339947195751862 NA NA NA hsa-miR-148a-3p SLC39A13 -0.748702855596996 3.93313343865641e-07 0.702545531021421 5.82346425244418e-19 miRNATAP -0.222800867605752 6.15944021935761e-18 NA NA NA hsa-miR-148a-3p SLC45A4 -0.748702855596996 3.93313343865641e-07 1.20758734416733 6.6417314824029e-07 mirMAP -0.79388527746553 1.02781346364025e-25 NA NA NA hsa-miR-148a-3p SLC7A11 -0.748702855596996 3.93313343865641e-07 3.47167805920945 1.56674476751757e-19 miRNATAP -0.536459394778507 4.08618619144432e-05 NA NA NA hsa-miR-148a-5p SLC7A11 -0.767626696027761 1.08359477494797e-06 3.47167805920945 1.56674476751757e-19 mirMAP -0.45940640813052 0.000184572264383865 NA NA NA hsa-miR-148a-3p SLC8A1 -0.748702855596996 3.93313343865641e-07 -1.67234164835265 3.98185932744172e-20 MirTarget -0.196962024419765 0.00156195195265746 NA NA NA hsa-miR-148a-5p SLC8A1 -0.767626696027761 1.08359477494797e-06 -1.67234164835265 3.98185932744172e-20 MirTarget -0.138546390898164 0.0179950030763537 NA NA NA hsa-miR-148a-5p SLIT3 -0.767626696027761 1.08359477494797e-06 0.157466553388729 0.504736595264199 MirTarget;miRNATAP -0.386272237761703 6.07756382639517e-08 NA NA NA hsa-miR-148a-3p SMAD5 -0.748702855596996 3.93313343865641e-07 0.163025158576987 0.0964365530955469 MirTarget -0.118682964369505 0.000191401765007103 NA NA NA hsa-miR-148a-3p SMARCD1 -0.748702855596996 3.93313343865641e-07 0.643238619401545 1.43047276243426e-17 miRNATAP -0.179723038421978 4.85357530537153e-13 NA NA NA hsa-miR-181a-5p SMC1A 0.250113435902954 0.0551933249319293 0.0651833474337025 0.510370716253497 mirMAP -0.117542893899761 0.00146146139664929 NA NA NA hsa-miR-181c-5p SMC1A -0.00639394152050299 0.969127212255928 0.0651833474337025 0.510370716253497 mirMAP -0.102787280067137 0.000412049730773496 NA NA NA hsa-miR-193b-3p SMC3 -0.166697207281748 0.272022543069482 0.203644948628179 0.0850721957839735 miRNAWalker2_validate -0.129842117232487 0.000624818169450842 NA NA NA hsa-miR-148a-3p SMS -0.748702855596996 3.93313343865641e-07 0.164928667940139 0.0543736469004317 MirTarget;miRNATAP -0.129001086204858 3.12204121587798e-06 NA NA NA hsa-miR-148a-3p SNN -0.748702855596996 3.93313343865641e-07 0.139978056935726 0.1435877993436 MirTarget;miRNATAP -0.188024868908952 7.9924616995449e-10 NA NA NA hsa-miR-148a-3p SNPH -0.748702855596996 3.93313343865641e-07 0.669218523436135 0.00151404681785838 mirMAP;miRNATAP -0.61217632083124 2.03479411590929e-20 NA NA NA hsa-miR-148a-3p SNRPD1 -0.748702855596996 3.93313343865641e-07 0.672324466321794 7.13760714023798e-11 MirTarget -0.193675346146832 1.11177175064211e-08 NA NA NA hsa-miR-148a-3p SOX11 -0.748702855596996 3.93313343865641e-07 1.40787252269122 1.13853242912301e-05 miRNATAP -1.07091287526546 4.31008991786723e-27 NA NA NA hsa-miR-148a-5p SPAG1 -0.767626696027761 1.08359477494797e-06 -0.19328984154616 0.240342040643324 MirTarget -0.289957379545726 4.97351325571963e-09 NA NA NA hsa-miR-148a-5p SPOCK1 -0.767626696027761 1.08359477494797e-06 2.53504187150893 2.13962835594159e-10 mirMAP -0.637315071847255 2.59258456535903e-07 NA NA NA hsa-miR-148a-5p SPRY4 -0.767626696027761 1.08359477494797e-06 -0.334402157998528 0.0123258475801913 mirMAP -0.267843808321516 2.35629523962814e-11 NA NA NA hsa-miR-148a-5p SRI -0.767626696027761 1.08359477494797e-06 0.0924236664470337 0.553975286176287 MirTarget -0.20758793207056 1.20033451964383e-05 NA NA NA hsa-miR-148a-3p SRRM3 -0.748702855596996 3.93313343865641e-07 1.37120942849299 0.000135491162818506 mirMAP -0.705228453146128 1.29888212423459e-09 NA NA NA hsa-miR-148a-3p SSBP2 -0.748702855596996 3.93313343865641e-07 -0.124114637043314 0.588013472488598 MirTarget -0.630106222214928 1.58562698769295e-18 NA NA NA hsa-miR-148a-5p SSH2 -0.767626696027761 1.08359477494797e-06 0.308455324497014 0.00122785737698821 mirMAP -0.199627445491238 2.80984313511262e-12 NA NA NA hsa-miR-30b-5p STAG1 -0.54056186708617 2.44688760798341e-05 -0.178198619776885 0.243967920887864 MirTarget -0.20850853639894 0.00030033116479739 NA NA NA hsa-miR-30d-5p STAG1 0.718283816348023 2.47422074061352e-08 -0.178198619776885 0.243967920887864 MirTarget;mirMAP -0.140033891643882 0.0142456491944109 NA NA NA hsa-miR-148a-5p STIL -0.767626696027761 1.08359477494797e-06 2.27606240799083 3.73674028972289e-36 MirTarget -0.173703465713217 0.00422850984035576 NA NA NA hsa-miR-148a-5p STK17A -0.767626696027761 1.08359477494797e-06 0.314638333063388 0.00523777429321398 MirTarget -0.207129826952483 1.06295023987549e-09 NA NA NA hsa-miR-148a-3p STK24 -0.748702855596996 3.93313343865641e-07 0.19247054896382 0.0273376591701568 mirMAP -0.171740620181524 7.53809919687189e-10 NA NA NA hsa-miR-148a-3p STK38L -0.748702855596996 3.93313343865641e-07 -0.426911630799545 7.77556827907282e-05 MirTarget -0.167682651806632 1.85608742152544e-06 NA NA NA hsa-miR-148a-3p SULF1 -0.748702855596996 3.93313343865641e-07 0.197109789821601 0.550013822507954 miRNATAP -1.08819294190457 4.5465214196856e-27 NA NA NA hsa-miR-148a-5p SULF1 -0.767626696027761 1.08359477494797e-06 0.197109789821601 0.550013822507954 mirMAP -0.924538757436748 6.02980730087493e-22 NA NA NA hsa-miR-148a-3p SYNC -0.748702855596996 3.93313343865641e-07 0.753263996165908 0.0787951206130033 MirTarget -0.607317552921147 1.27523918840447e-05 NA NA NA hsa-miR-148a-5p SYNM -0.767626696027761 1.08359477494797e-06 0.428208488873809 0.0200702605791222 MirTarget -0.125822056926078 0.0262069455720667 NA NA NA hsa-miR-148a-5p SYT11 -0.767626696027761 1.08359477494797e-06 0.0846108163814832 0.585251586091851 mirMAP -0.294888079632295 2.25531094365205e-10 NA NA NA hsa-miR-148a-3p TAF4B -0.748702855596996 3.93313343865641e-07 -0.601598142975973 0.0171657841614686 MirTarget -0.581392909704103 5.01906359473338e-13 NA NA NA hsa-miR-148a-3p TANC2 -0.748702855596996 3.93313343865641e-07 -0.0777608116505228 0.723192087672004 mirMAP -0.620627143687002 1.35989055902964e-19 NA NA NA hsa-miR-148a-5p TCF21 -0.767626696027761 1.08359477494797e-06 -2.50041580080969 5.23151011651186e-23 mirMAP -0.232662760589155 0.00454740071549428 NA NA NA hsa-miR-148a-3p TCF4 -0.748702855596996 3.93313343865641e-07 -0.131793886763984 0.355169273660664 MirTarget;miRNATAP -0.199055475462496 1.6155869003118e-05 NA NA NA hsa-miR-148a-3p TFCP2L1 -0.748702855596996 3.93313343865641e-07 0.0691205247491691 0.814888444830697 mirMAP -0.700020888321756 7.52810321140122e-14 NA NA NA hsa-miR-148a-5p TFCP2L1 -0.767626696027761 1.08359477494797e-06 0.0691205247491691 0.814888444830697 mirMAP -0.565854308791003 1.68492823522161e-10 NA NA NA hsa-miR-148a-3p TFEB -0.748702855596996 3.93313343865641e-07 -0.0772531299287356 0.585189118739078 miRNATAP -0.129311975896433 0.0050431934936616 NA NA NA hsa-miR-148a-5p TFEC -0.767626696027761 1.08359477494797e-06 -0.739164907989905 0.000422788833204394 mirMAP -0.232570035074804 0.000304929976796017 NA NA NA hsa-miR-148a-3p TFRC -0.748702855596996 3.93313343865641e-07 0.937052448042543 3.46645820917872e-11 miRNATAP -0.216653819308525 3.86635919504837e-06 NA NA NA hsa-miR-148a-3p TGFA -0.748702855596996 3.93313343865641e-07 -2.03762583735332 1.70833612877746e-11 miRNATAP -0.794888513212377 5.2082388955199e-16 NA NA NA hsa-miR-148a-3p TGFB2 -0.748702855596996 3.93313343865641e-07 0.529934214584709 0.036730862150581 MirTarget;miRNATAP -0.661431979951743 1.43220896593668e-16 NA NA NA hsa-miR-106b-5p TGFBR2 0.648901865047099 8.24870862047885e-09 -0.522706741081292 3.47206054315007e-05 miRNATAP -0.368277930860382 4.29748674542316e-12 NA NA NA hsa-miR-130b-3p TGFBR2 0.687190305027546 0.000109068658562255 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.131252693120461 0.000144540113312326 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 0.698861147045461 2.43854106455398e-05 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.203186001893041 2.94531720390227e-08 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 0.918028187958706 1.90229510425322e-05 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate -0.192780882131928 5.02272007870357e-12 NA NA NA hsa-miR-19a-3p TGFBR2 1.01712596153672 2.57753201450625e-07 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.149425406079401 1.09582904607366e-06 NA NA NA hsa-miR-19b-3p TGFBR2 0.601279551368824 0.00016685097085251 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.16137896859351 2.62064707293945e-05 NA NA NA hsa-miR-20a-5p TGFBR2 0.854326758727003 5.04256669663285e-07 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.177394018081005 6.48951647363697e-07 NA NA NA hsa-miR-21-5p TGFBR2 1.51084295924322 1.54551622173259e-34 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.236840105633096 2.41705180023436e-07 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-301a-3p TGFBR2 0.842910511640361 1.43446467417891e-06 -0.522706741081292 3.47206054315007e-05 miRNATAP -0.183722985598573 1.11942744399345e-07 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-454-3p TGFBR2 0.668749059573955 2.42670710515113e-06 -0.522706741081292 3.47206054315007e-05 miRNATAP -0.109462345848673 0.0115970871562665 NA NA NA hsa-miR-501-3p TGFBR2 0.999540908940094 2.77358485581974e-11 -0.522706741081292 3.47206054315007e-05 TargetScan -0.116887889145825 0.0037841236086272 NA NA NA hsa-miR-590-5p TGFBR2 -0.103355559980404 0.310027295317092 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.253149374960949 3.5308611333711e-05 NA NA NA hsa-miR-92a-3p TGFBR2 0.212391012518195 0.134292268089997 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate -0.17351362748106 7.02401539230513e-05 NA NA NA hsa-miR-93-5p TGFBR2 1.39518349670953 2.84167728726712e-25 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.263677361634044 7.09611188180981e-10 NA NA NA hsa-miR-148a-3p TGIF2 -0.748702855596996 3.93313343865641e-07 0.183370689181392 0.147188585278003 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.247629083555228 9.91349025355731e-10 26638007 Down Regulation of miR 148a Promotes Metastasis by DNA Methylation and is Associated with Prognosis of Skin Cancer by Targeting TGIF2; The purpose of this study was to investigate the methylation status of miR-148a and its effects on the metastasis and prognosis of skin cancer as well as the interaction with TGIF2 gene; Luciferase reporter assay found that TGIF2 gene was a target gene and its expression was suppressed by miR-148a in skin cancer; CONCLUSIONS Taken together the expression of miR-148a was regulated by DNA methylation and targeted by TGIF2 metastasis;worse prognosis sarcoma hsa-miR-148a-5p TIFAB -0.767626696027761 1.08359477494797e-06 0.964028681294563 0.000554081418971492 mirMAP -0.204818101428451 0.0174208177857467 NA NA NA hsa-miR-148a-5p TMC7 -0.767626696027761 1.08359477494797e-06 2.03760714579858 4.07529066351364e-21 mirMAP -0.56579736053508 3.30415473864888e-17 NA NA NA hsa-miR-148a-3p TMCC3 -0.748702855596996 3.93313343865641e-07 0.117668394353186 0.425707008413695 MirTarget -0.155039139325215 0.00125905353152064 NA NA NA hsa-miR-148a-5p TMEM108 -0.767626696027761 1.08359477494797e-06 0.99389223387558 4.11528829750623e-05 mirMAP -0.485054102748095 3.67293887425082e-11 NA NA NA hsa-miR-148a-3p TMEM120B -0.748702855596996 3.93313343865641e-07 1.34193310296135 3.11902100235044e-43 mirMAP -0.172599931857059 8.02056011224422e-07 NA NA NA hsa-miR-148a-5p TMEM164 -0.767626696027761 1.08359477494797e-06 1.2706908651988 7.63591092247221e-16 mirMAP -0.232679487331266 2.78676389432874e-06 NA NA NA hsa-miR-148a-3p TMEM54 -0.748702855596996 3.93313343865641e-07 0.339956153918932 0.165699757140974 MirTarget -0.55222112886462 1.54566938175757e-12 NA NA NA hsa-miR-148a-5p TMEM86A -0.767626696027761 1.08359477494797e-06 -0.317170199070764 0.0163079984467626 mirMAP -0.10436678589645 0.00997424808459655 NA NA NA hsa-miR-148a-3p TMEM9B -0.748702855596996 3.93313343865641e-07 0.0287463993115633 0.684276222499031 miRNAWalker2_validate;miRNATAP -0.115744129064157 3.2275770465905e-07 NA NA NA hsa-miR-148a-5p TMOD2 -0.767626696027761 1.08359477494797e-06 0.273439557141349 0.0664976053061536 mirMAP -0.275653680837853 7.75394578618351e-10 NA NA NA hsa-miR-148a-3p TMSB10 -0.748702855596996 3.93313343865641e-07 0.855988582085651 2.64785852790295e-05 miRNATAP -0.801496222431267 2.12040705537655e-39 NA NA NA hsa-miR-148a-5p TNIK -0.767626696027761 1.08359477494797e-06 -1.30698718080542 2.11831969644423e-06 mirMAP -0.343581232598475 5.33741176102067e-05 NA NA NA hsa-miR-148a-3p TNIP2 -0.748702855596996 3.93313343865641e-07 0.335021770072243 5.14349905101051e-05 MirTarget -0.153853270059096 8.46593726591456e-09 NA NA NA hsa-miR-148a-5p TOX -0.767626696027761 1.08359477494797e-06 -0.725976975588079 0.0301887887319555 MirTarget -0.329087096760083 0.0013432664074863 NA NA NA hsa-miR-148a-3p TPCN1 -0.748702855596996 3.93313343865641e-07 0.601482422409012 3.05338746481423e-08 mirMAP -0.175550226951548 8.36740565092831e-07 NA NA NA hsa-miR-26b-5p TRAF1 -1.10804856399744 4.14176110314282e-22 0.712897834079886 6.33601713412082e-09 miRNAWalker2_validate -0.146366230286123 0.00384999561270946 NA NA NA hsa-miR-30e-3p TRAF1 -1.20845647373031 3.10263633528203e-25 0.712897834079886 6.33601713412082e-09 mirMAP -0.220388103763073 7.10147510001104e-06 NA NA NA hsa-miR-378a-3p TRAF1 -1.1920055906972 3.23538871733634e-10 0.712897834079886 6.33601713412082e-09 miRNAWalker2_validate -0.124374707900819 6.92942238884749e-05 NA NA NA hsa-miR-148a-3p TRAK1 -0.748702855596996 3.93313343865641e-07 0.112414901890156 0.161096546776779 miRNATAP -0.138439950489541 7.44379860540538e-08 NA NA NA hsa-miR-148a-3p TRAK2 -0.748702855596996 3.93313343865641e-07 -0.134753128051574 0.118953684351514 MirTarget;miRNATAP -0.138259168259446 6.72843502340937e-07 NA NA NA hsa-miR-148a-3p TRIM59 -0.748702855596996 3.93313343865641e-07 1.7356935499647 4.96522875209022e-19 miRNAWalker2_validate;MirTarget -0.530631145085023 1.38548428892168e-16 NA NA NA hsa-miR-148a-3p TRPS1 -0.748702855596996 3.93313343865641e-07 0.234327311753334 0.28887714546093 miRNATAP -0.232765974533109 0.00122300098269749 NA NA NA hsa-miR-148a-5p TTC39A -0.767626696027761 1.08359477494797e-06 2.64467452765163 1.3333642353103e-14 mirMAP -0.874111214316927 8.05305470528201e-17 NA NA NA hsa-miR-139-5p TTK -2.11299531796557 8.16407076415038e-28 4.46695225538541 3.90954998066403e-48 miRanda -1.02753150497536 5.11914670343957e-45 NA NA NA hsa-miR-215-5p TTK -0.981544773246509 3.14452272477156e-05 4.46695225538541 3.90954998066403e-48 miRNAWalker2_validate -0.154558614985227 0.0292381161076613 NA NA NA hsa-miR-455-3p TTK -1.3998033821095 5.72010709806871e-17 4.46695225538541 3.90954998066403e-48 miRNATAP -0.457661482122706 1.91508543926432e-06 NA NA NA hsa-miR-148a-3p TTYH3 -0.748702855596996 3.93313343865641e-07 0.770555614902691 1.06180020960171e-06 mirMAP -0.336909304109069 4.30253872401559e-11 NA NA NA hsa-miR-148a-3p UBASH3B -0.748702855596996 3.93313343865641e-07 -0.366176880641331 0.0811617780784009 MirTarget -0.844727394486042 1.96609914042261e-42 NA NA NA hsa-miR-148a-3p UBE2D1 -0.748702855596996 3.93313343865641e-07 0.0779402641757883 0.369347660871645 MirTarget;miRNATAP -0.171046474154817 6.65939304887809e-10 NA NA NA hsa-miR-148a-3p UCP3 -0.748702855596996 3.93313343865641e-07 0.738404617511284 2.64780777542046e-07 MirTarget;miRNATAP -0.159569280850398 0.000757623579332943 NA NA NA hsa-miR-148a-3p UNC13A -0.748702855596996 3.93313343865641e-07 1.88006027872507 4.70766140336401e-08 mirMAP -0.737009176311451 4.54389881051152e-11 NA NA NA hsa-miR-148a-3p VANGL1 -0.748702855596996 3.93313343865641e-07 0.205997711038247 0.0305684838094997 mirMAP -0.147424701729889 1.65338009649548e-06 NA NA NA hsa-miR-148a-3p VASH1 -0.748702855596996 3.93313343865641e-07 0.376667961316505 0.00837588570446168 mirMAP -0.483186841432644 2.09378989906879e-28 NA NA NA hsa-miR-148a-5p VASH2 -0.767626696027761 1.08359477494797e-06 1.99409120294188 1.83824386478745e-12 MirTarget -0.247568847603436 0.00550226408025736 NA NA NA hsa-miR-148a-5p VEPH1 -0.767626696027761 1.08359477494797e-06 -1.68830506563898 3.41017192020284e-05 MirTarget -0.840106607505025 8.81252286790049e-12 NA NA NA hsa-miR-148a-5p VGLL3 -0.767626696027761 1.08359477494797e-06 -0.294230399406651 0.235396784808845 MirTarget;miRNATAP -0.460226026777192 6.7571612444397e-10 NA NA NA hsa-miR-148a-3p VSIG1 -0.748702855596996 3.93313343865641e-07 1.90287436342957 8.4567956200768e-06 MirTarget -1.08529741673112 1.88037146106369e-15 NA NA NA hsa-miR-148a-3p VSIG10 -0.748702855596996 3.93313343865641e-07 0.873850880690775 6.42061314499011e-13 MirTarget -0.233949805248073 5.70720661265099e-09 NA NA NA hsa-miR-148a-5p WDFY3 -0.767626696027761 1.08359477494797e-06 -0.56665445395217 1.30950023006267e-05 mirMAP -0.152669643520289 0.000135358240078614 NA NA NA hsa-miR-148a-5p WDFY4 -0.767626696027761 1.08359477494797e-06 -0.772515998360695 0.00122387279638213 mirMAP -0.294925124037632 5.57607226222924e-05 NA NA NA hsa-miR-148a-3p WNK2 -0.748702855596996 3.93313343865641e-07 -1.89518323977929 0.000316140316980393 mirMAP -1.46012560842666 1.47894869196561e-18 NA NA NA hsa-miR-10b-5p WNT7B 2.86931593037303 6.97409423207806e-23 -2.49986156980565 3.55477150766295e-09 mirMAP -0.274981207829556 5.13137898629338e-05 NA NA NA hsa-miR-34a-5p WNT7B 1.03694231790865 5.74864019540594e-14 -2.49986156980565 3.55477150766295e-09 mirMAP -0.871435014929295 2.29802092991709e-09 NA NA NA hsa-miR-505-3p WNT7B -1.20027021591555 1.27927500175937e-13 -2.49986156980565 3.55477150766295e-09 miRNATAP -0.343304152336908 0.00653008300029439 NA NA NA hsa-miR-664a-5p WNT7B -0.0738022124558593 0.597681758599428 -2.49986156980565 3.55477150766295e-09 MirTarget -0.350084715832488 0.0208450119464205 NA NA NA hsa-miR-148a-3p XYLT1 -0.748702855596996 3.93313343865641e-07 -0.33071246838403 0.0992663538586554 mirMAP -0.574785330152198 4.45980178241601e-20 NA NA NA hsa-miR-148a-5p XYLT1 -0.767626696027761 1.08359477494797e-06 -0.33071246838403 0.0992663538586554 mirMAP -0.466461462283832 4.70816583336705e-15 NA NA NA hsa-miR-148a-3p YWHAB -0.748702855596996 3.93313343865641e-07 0.173432047741129 0.000884243127746855 MirTarget;miRNATAP -0.132820922282045 4.13292521804208e-16 NA NA NA hsa-miR-148a-3p ZBED4 -0.748702855596996 3.93313343865641e-07 0.53235542847144 2.61984249684361e-08 miRNATAP -0.143825624792037 4.72475716954346e-06 NA NA NA hsa-miR-148a-5p ZBTB34 -0.767626696027761 1.08359477494797e-06 0.377013703257521 0.000168925671855812 mirMAP -0.10888694251576 0.000397113080523626 NA NA NA hsa-miR-148a-3p ZBTB46 -0.748702855596996 3.93313343865641e-07 0.368572640104064 0.00472649256163026 mirMAP -0.261027892187004 4.71083373690452e-10 NA NA NA hsa-miR-148a-3p ZDHHC23 -0.748702855596996 3.93313343865641e-07 0.31113543845786 0.027353194603354 MirTarget -0.193066199183344 2.48865332154847e-05 NA NA NA hsa-miR-148a-3p ZDHHC7 -0.748702855596996 3.93313343865641e-07 0.0927070329222683 0.321096181728645 MirTarget;miRNATAP -0.348656796446493 6.48216350335255e-36 NA NA NA hsa-miR-148a-5p ZEB2 -0.767626696027761 1.08359477494797e-06 -1.50896689448163 2.21480558222559e-19 miRNATAP -0.197498228144374 0.000226841317066931 NA NA NA hsa-miR-148a-3p ZFPM2 -0.748702855596996 3.93313343865641e-07 -2.22408950189141 1.94401967403455e-22 miRNATAP -0.168857556123059 0.0322360782737704 NA NA NA hsa-miR-148a-5p ZNF280B -0.767626696027761 1.08359477494797e-06 -0.561022604309022 0.0472865300264828 mirMAP -0.348245555275097 5.45410818305399e-05 NA NA NA hsa-miR-148a-5p ZNF292 -0.767626696027761 1.08359477494797e-06 0.0215859460095364 0.87155801883766 MirTarget -0.192467962347987 1.92564227206117e-06 NA NA NA hsa-miR-148a-5p ZNF391 -0.767626696027761 1.08359477494797e-06 0.60089310269016 0.0488756297254734 mirMAP -0.277308886875746 0.00302249001852534 NA NA NA hsa-miR-148a-5p ZNF423 -0.767626696027761 1.08359477494797e-06 -0.0193608514881518 0.924397085233393 mirMAP -0.238897318587614 0.000120804395605443 NA NA NA hsa-miR-148a-3p ZNF587 -0.748702855596996 3.93313343865641e-07 0.416605076067025 0.000245987062294619 mirMAP -0.132400344546222 0.000367574330535695 NA NA NA hsa-miR-148a-3p ZNF618 -0.748702855596996 3.93313343865641e-07 0.943831859691578 2.40047580237559e-12 miRNATAP -0.390230443941614 1.78915488594973e-19 NA NA NA hsa-miR-148a-3p ZNF665 -0.748702855596996 3.93313343865641e-07 -0.0424406995812787 0.875598989998811 MirTarget -0.24526069818326 0.00555092355538439 NA NA NA hsa-miR-148a-3p ZNF821 -0.748702855596996 3.93313343865641e-07 0.740296522200471 1.06023377674518e-11 miRNATAP -0.137566867283079 0.00014914298275068 NA NA NA hsa-miR-148a-5p ZNF827 -0.767626696027761 1.08359477494797e-06 -1.01635412446374 0.000468183081986259 mirMAP -0.406311331865048 4.80847282837678e-06 NA NA NA hsa-miR-148a-3p ZPLD1 -0.748702855596996 3.93313343865641e-07 -1.71908463654629 7.12931687350314e-05 MirTarget -0.890083843046829 1.93662188896187e-10 NA NA NA