miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-143-3p	ABHD14A	-2.5789192793377	1.55518999614836e-14	0.118876821357783	0.605151904106821	MirTarget	-0.145965440729365	4.33634215779341e-06		NA	NA	NA
hsa-miR-143-3p	BBC3	-2.5789192793377	1.55518999614836e-14	1.11623140689651	3.60476730272011e-07	miRNATAP	-0.130165583850532	2.4105347480111e-05		NA	NA	NA
hsa-miR-143-3p	CA2	-2.5789192793377	1.55518999614836e-14	1.19907838013508	0.0114888878081156	MirTarget	-0.176719667164053	0.00779827040984465		NA	NA	NA
hsa-miR-143-3p	CCDC58	-2.5789192793377	1.55518999614836e-14	1.11363573805266	6.11976687014297e-15	MirTarget;miRNATAP	-0.127481656910178	2.5508932133643e-10		NA	NA	NA
hsa-miR-143-3p	CREBZF	-2.5789192793377	1.55518999614836e-14	0.369623242112343	0.0115899957994805	MirTarget	-0.105256164844637	1.83235554311751e-07		NA	NA	NA
hsa-miR-143-3p	CYP2C9	-2.5789192793377	1.55518999614836e-14	1.50792958679346	0.0338384149984756	MirTarget	-0.272355339344404	0.00613017080671775		NA	NA	NA
hsa-miR-143-3p	DNMT3A	-2.5789192793377	1.55518999614836e-14	0.850793143902836	1.00169897998871e-06	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.111773174433085	4.38845553262621e-06	19638978;24218337	Using in silico predictions DNA methyltranferase 3A DNMT3A was defined as a potential target of miR-143; Restoration of the miR-143 expression in colon cell lines decreased tumour cell growth and soft-agar colony formation and downregulated the DNMT3A expression in both mRNA and protein levels; DNMT3A was shown to be a direct target of miR-143 by luciferase reporter assay; Furthermore the miR-143 expression was observed to be inversely correlated with DNMT3A mRNA and protein expression in CRC tissues; Our findings suggest that miR-143 regulates DNMT3A in CRC;Ectopic expression of miR-143 inhibited proliferation and soft agar colony formation of breast cancer cells and also downregulated DNA methyltransferase 3A DNMT3A expression on both mRNA and protein levels; DNMT3A was demonstrated to be a direct target of miR-143 by luciferase reporter assay; Furthermore miR-143 expression was observed to be inversely correlated with DNMT3A mRNA and protein expression in breast cancer tissues; Our findings suggest that miR-143 regulates DNMT3A in breast cancer cells	;	colorectal cancer;breast cancer
hsa-miR-143-3p	DTNB	-2.5789192793377	1.55518999614836e-14	1.03580573857464	1.29039878426561e-05	miRNATAP	-0.162358947957343	9.50135311572608e-07		NA	NA	NA
hsa-miR-143-3p	DYRK1B	-2.5789192793377	1.55518999614836e-14	0.713985413778355	0.00159921749393038	MirTarget;miRNATAP	-0.120702933905286	0.000130697318586514		NA	NA	NA
hsa-miR-143-3p	EME1	-2.5789192793377	1.55518999614836e-14	3.12525624285343	5.37401359050463e-31	MirTarget	-0.236973099780248	3.06180530145021e-09		NA	NA	NA
hsa-miR-143-3p	ERBB4	-2.5789192793377	1.55518999614836e-14	-0.99392595585163	0.14130085734173	miRNATAP	-0.205756992255883	0.0294777260385657		NA	NA	NA
hsa-miR-143-3p	FAM111A	-2.5789192793377	1.55518999614836e-14	0.795552455122973	6.44400967052281e-07	MirTarget	-0.132902107794098	2.04449076826792e-09		NA	NA	NA
hsa-miR-143-3p	FAM60A	-2.5789192793377	1.55518999614836e-14	0.718618539288163	3.38890434858948e-05	MirTarget;miRNATAP	-0.128810209326192	8.5425266818993e-08		NA	NA	NA
hsa-miR-143-3p	FBXO46	-2.5789192793377	1.55518999614836e-14	0.836451633739176	6.35882832482893e-09	miRNATAP	-0.120777995414117	1.75846933202618e-09		NA	NA	NA
hsa-miR-143-3p	FHIT	-2.5789192793377	1.55518999614836e-14	-0.651649067614083	0.116560961884213	miRNAWalker2_validate;miRTarBase;MirTarget	-0.136631447087173	0.0185754415170146		NA	NA	NA
hsa-miR-143-3p	GNL3	-2.5789192793377	1.55518999614836e-14	0.583677704642714	0.00135999575131434	MirTarget	-0.14203373266355	1.61100002548446e-08		NA	NA	NA
hsa-miR-143-3p	GRHL2	-2.5789192793377	1.55518999614836e-14	2.79562705012351	7.97545074500909e-10	MirTarget;miRNATAP	-0.218102606575244	0.000749424041670115		NA	NA	NA
hsa-miR-143-3p	HK2	-2.5789192793377	1.55518999614836e-14	0.979120567552045	0.000248360562508928	miRNAWalker2_validate;miRTarBase	-0.157591468356014	2.38746201397272e-05	25322940;27574783;23376635;22691140;26269764;24033605	Furthermore knockdown of ATG2B and hexokinase 2 a key enzyme in glycolysis and another target of miR-143 co-ordinated to inhibit the proliferation of H1299 cells;We previously identified hexokinase 2 the major glycolytic enzyme as a target gene of miR-143 in TNBC;We show that miR-143 is significantly down-regulated in glioma tissues and glioblastoma stem-like cells GSLCs while miR-143 over-expression inhibits glycolysis by directly targeting hexokinase 2 and promotes differentiation of GSLCs;MicroRNA 143 down regulates Hexokinase 2 in colon cancer cells; Here we report the identification of Hexokinase 2 HK2 as a direct target of miR-143; We have identified and validated HK2 as a miR-143 target; Furthermore our results indicate that miR-143 mediated down-regulation of HK2 affects glucose metabolism in colon cancer cells;MicroRNA 143 acts as a tumor suppressor by targeting hexokinase 2 in human prostate cancer; Furthermore we identified hexokinase 2 HK2 a metabolic enzyme that executes the first step of aerobic glycolysis as a target of miR-143 in prostate cancer; Knockdown of HK2 recapitulated the effects of miR-143 and accompanied with decreased glucose metabolism;Luciferase reporter assays showed that both miR-143 and miR-145 directly regulated HK2	;;differentiation;;;	lung squamous cell cancer;breast cancer;glioblastoma;colon cancer;prostate cancer;kidney renal cell cancer
hsa-miR-143-3p	HMGA1	-2.5789192793377	1.55518999614836e-14	1.72815855416782	1.05455033865356e-12	miRNATAP	-0.134752061136185	0.000100915602175292		NA	NA	NA
hsa-miR-143-3p	HOXA5	-2.5789192793377	1.55518999614836e-14	0.189757288716074	0.583395904525936	miRNATAP	-0.126684229284999	0.00865707540503008		NA	NA	NA
hsa-miR-143-3p	HRAS	-2.5789192793377	1.55518999614836e-14	0.623195449314017	0.00175543589552248	miRNAWalker2_validate;miRTarBase	-0.162589208332201	3.09270971499286e-09	21276449	The Evi1 microRNA 143 K Ras axis in colon cancer		colon cancer
hsa-miR-143-3p	LIMD1	-2.5789192793377	1.55518999614836e-14	0.487304759021365	0.00435961861280182	mirMAP	-0.107766742915083	5.44163804930862e-06		NA	NA	NA
hsa-miR-143-3p	LPAR2	-2.5789192793377	1.55518999614836e-14	2.09195803325664	2.37447910992728e-18	miRNATAP	-0.279346101272712	9.91112750776813e-17		NA	NA	NA
hsa-miR-143-3p	MOGS	-2.5789192793377	1.55518999614836e-14	1.3085502464	1.15159115292941e-24	MirTarget	-0.138539573825495	3.54096867736373e-14		NA	NA	NA
hsa-miR-143-3p	MYO6	-2.5789192793377	1.55518999614836e-14	0.447732292238672	0.033989651113651	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.105394984401393	0.000334691060131013	20353999	A computational search indicated the 3'-untranslated region UTR of the mRNA for myosin VI MYO6 as a potential target for both miR-143 and miR-145 the expression of which was reduced in the tumor tissues; In luciferase reporter analysis we find a significant negative regulatory effect on the MYO6 3'UTR by both miR-143 and miR-145; Mutation of the potential binding sites for miR-143 and miR-145 in the MYO6 3'UTR resulted in a loss of responsiveness to the corresponding miRNA; Our data indicate that miR-143 and miR-145 are involved in the regulation of MYO6 expression and possibly in the development of prostate cancer		prostate cancer
hsa-miR-143-3p	NFXL1	-2.5789192793377	1.55518999614836e-14	0.687673671782941	5.38173045930639e-05	MirTarget	-0.107118231491788	6.35471457495707e-06		NA	NA	NA
hsa-miR-143-3p	ONECUT2	-2.5789192793377	1.55518999614836e-14	2.28779793944805	0.000665995858924987	mirMAP;miRNATAP	-0.337675558342298	0.000332561865737873		NA	NA	NA
hsa-miR-143-3p	PACRG	-2.5789192793377	1.55518999614836e-14	-2.3566345998251	0.000542537929139886	miRNATAP	-0.241824663161273	0.01155982495509		NA	NA	NA
hsa-miR-143-3p	RAB11FIP4	-2.5789192793377	1.55518999614836e-14	1.84684484894314	1.35843950264268e-08	MirTarget	-0.209017682145975	5.11190865747781e-06		NA	NA	NA
hsa-miR-143-3p	RALGPS1	-2.5789192793377	1.55518999614836e-14	-0.476860374410031	0.133170705908628	mirMAP	-0.103555879104582	0.0195979554071881		NA	NA	NA
hsa-miR-143-3p	SAMD12	-2.5789192793377	1.55518999614836e-14	-0.167501629138361	0.692218309710102	mirMAP	-0.135041317922143	0.0222749895504476		NA	NA	NA
hsa-miR-143-3p	SEC14L4	-2.5789192793377	1.55518999614836e-14	0.859969952030269	0.204206781257997	MirTarget	-0.211135913793745	0.0257732212022257		NA	NA	NA
hsa-miR-143-3p	SIX4	-2.5789192793377	1.55518999614836e-14	1.73242497054724	7.49612549039834e-11	miRNATAP	-0.175806977544877	3.08952500687795e-06		NA	NA	NA
hsa-miR-143-3p	SP6	-2.5789192793377	1.55518999614836e-14	1.94379121291738	2.84531504234265e-05	mirMAP	-0.169213168110245	0.00973699306614178		NA	NA	NA
hsa-miR-143-3p	SRCIN1	-2.5789192793377	1.55518999614836e-14	1.21320494002451	0.0190825630394152	MirTarget	-0.447522558626953	3.01241380151252e-10		NA	NA	NA
hsa-miR-143-3p	TANC2	-2.5789192793377	1.55518999614836e-14	1.16934011511191	8.73048160340949e-07	miRNATAP	-0.111531705141276	0.000876037640928255		NA	NA	NA
hsa-miR-143-3p	TIGD5	-2.5789192793377	1.55518999614836e-14	1.09197695425063	1.92990997073421e-11	MirTarget	-0.167889018850467	1.06285632679735e-13		NA	NA	NA
hsa-miR-143-3p	TMEM105	-2.5789192793377	1.55518999614836e-14	0.898018128360463	0.0985424895304888	mirMAP	-0.185296391597417	0.0147635873927499		NA	NA	NA
hsa-miR-143-3p	TMEM69	-2.5789192793377	1.55518999614836e-14	0.827565556189882	1.08527094658589e-11	MirTarget	-0.107668118844772	2.55690695910021e-10		NA	NA	NA
hsa-miR-143-3p	TOR2A	-2.5789192793377	1.55518999614836e-14	1.13867925227755	1.30654147011355e-15	mirMAP	-0.12292810503416	1.12882933453203e-09		NA	NA	NA
hsa-miR-143-3p	TSPAN13	-2.5789192793377	1.55518999614836e-14	0.696393145196957	0.00280343349182658	miRNATAP	-0.126676487805664	9.59202494529478e-05		NA	NA	NA
hsa-miR-143-3p	ZDHHC23	-2.5789192793377	1.55518999614836e-14	1.38573954815051	1.46092390923618e-08	MirTarget	-0.195981721139595	1.00201088721191e-08		NA	NA	NA
hsa-miR-143-3p	ZNF182	-2.5789192793377	1.55518999614836e-14	0.507061842225121	0.00171338650578026	MirTarget	-0.109518384295874	1.00364149680462e-06		NA	NA	NA
hsa-miR-143-3p	ZNF514	-2.5789192793377	1.55518999614836e-14	0.494784023658716	0.0137577081300454	MirTarget	-0.122101660509757	1.1738752543494e-05		NA	NA	NA