miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-186-5p APC 0.445443449112564 0.185447310527704 -0.0767747610151472 0.842336162144662 miRNAWalker2_validate -0.186375765100707 0.00487494868289952 NA NA NA hsa-miR-30a-3p APC -1.22212086897848 0.167565797592104 -0.0767747610151472 0.842336162144662 MirTarget;miRNATAP -0.110308714220782 5.55003156650705e-06 NA NA NA hsa-miR-320b APC 0.20205459771295 0.727216419960509 -0.0767747610151472 0.842336162144662 miRanda -0.120780596736221 0.00135470702580849 NA NA NA hsa-miR-374b-5p APC -0.114749866169918 0.764888930049438 -0.0767747610151472 0.842336162144662 mirMAP -0.185591036709671 0.00127655314359827 NA NA NA hsa-miR-590-3p APC 2.35429565068338 2.79601879608564e-06 -0.0767747610151472 0.842336162144662 PITA;miRanda;mirMAP;miRNATAP -0.166334795891123 9.61904390448028e-05 NA NA NA hsa-miR-7-1-3p APC 1.43074343339835 0.00471215970502094 -0.0767747610151472 0.842336162144662 MirTarget -0.147209385006141 0.000605238293641448 NA NA NA hsa-miR-125a-5p APC2 -1.32352790615388 0.00714301627309467 3.13191261662562 0.00737055129114406 mirMAP -0.853096269997355 1.04500045510591e-10 NA NA NA hsa-miR-194-3p APC2 1.91743783341496 0.105383373371284 3.13191261662562 0.00737055129114406 mirMAP -0.158439963257808 0.00506903391988806 NA NA NA hsa-miR-28-5p APC2 -0.815636722979196 0.0221199948901761 3.13191261662562 0.00737055129114406 mirMAP -0.665871134811181 0.000433374657967794 NA NA NA hsa-let-7a-3p AXIN2 0.82512001802525 0.0468122405194487 -3.82407466660445 0.000332783445696398 miRNATAP -0.494045855852835 0.000853130932920837 NA NA NA hsa-let-7b-3p AXIN2 0.589364128513318 0.200507534602851 -3.82407466660445 0.000332783445696398 miRNATAP -0.497070558406417 0.000186469770166558 NA NA NA hsa-let-7f-2-3p AXIN2 1.02768112108475 0.0787293499732611 -3.82407466660445 0.000332783445696398 MirTarget -0.356438400092079 0.000841906314096363 NA NA NA hsa-miR-15a-5p AXIN2 2.0535411006904 1.91108976398046e-06 -3.82407466660445 0.000332783445696398 MirTarget;miRNATAP -0.550942102635856 8.04479638813504e-05 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 3.32329949959268 8.40210501034588e-13 -3.82407466660445 0.000332783445696398 miRTarBase;MirTarget;miRNATAP -0.467609074192871 0.00022236000942262 NA NA NA hsa-miR-16-2-3p AXIN2 3.79845098071094 1.49120139344659e-13 -3.82407466660445 0.000332783445696398 mirMAP -0.6823456604213 9.95304651839219e-10 NA NA NA hsa-miR-16-5p AXIN2 2.93575808220754 2.15436817162977e-10 -3.82407466660445 0.000332783445696398 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.695908366314422 3.93881990567234e-08 NA NA NA hsa-miR-205-5p AXIN2 8.08298115900323 3.83045179398654e-07 -3.82407466660445 0.000332783445696398 miRNATAP -0.296107118342617 9.25850565228752e-17 NA NA NA hsa-miR-221-3p AXIN2 0.94082283577318 0.174749164179978 -3.82407466660445 0.000332783445696398 miRNATAP -0.518384723281925 1.67647878628316e-09 NA NA NA hsa-miR-222-3p AXIN2 1.54730827524553 0.0223014220569407 -3.82407466660445 0.000332783445696398 miRNATAP -0.534987790682349 1.10747648966591e-09 NA NA NA hsa-miR-3614-5p AXIN2 4.50236405439456 2.75644515847367e-07 -3.82407466660445 0.000332783445696398 MirTarget;miRNATAP -0.261864275832248 0.000119330708648269 NA NA NA hsa-miR-590-3p AXIN2 2.35429565068338 2.79601879608564e-06 -3.82407466660445 0.000332783445696398 MirTarget;PITA;miRanda;miRNATAP -0.500291647228716 2.7183686924642e-05 NA NA NA hsa-miR-944 AXIN2 7.20925181386398 0.000823207457340648 -3.82407466660445 0.000332783445696398 MirTarget;PITA;miRNATAP -0.276130498452101 8.40746733798985e-17 NA NA NA hsa-let-7e-5p BTRC -0.111012524740586 0.814744515884005 -0.389242677076138 0.229517873289865 miRNAWalker2_validate -0.157958876446546 4.3321742453e-05 NA NA NA hsa-miR-125a-3p BTRC -0.0748960586927341 0.920735897434087 -0.389242677076138 0.229517873289865 miRanda -0.111382995850356 3.64944935788154e-06 NA NA NA hsa-miR-15b-5p BTRC 3.32329949959268 8.40210501034588e-13 -0.389242677076138 0.229517873289865 MirTarget;miRNATAP -0.14366136035681 0.000149866518688636 NA NA NA hsa-miR-16-5p BTRC 2.93575808220754 2.15436817162977e-10 -0.389242677076138 0.229517873289865 miRNAWalker2_validate;MirTarget;miRNATAP -0.130265266499023 0.000715839459970842 NA NA NA hsa-miR-28-5p BTRC -0.815636722979196 0.0221199948901761 -0.389242677076138 0.229517873289865 miRanda -0.236608660977103 4.38097837138535e-06 NA NA NA hsa-miR-339-5p BTRC 1.23326828594484 0.0307501214818698 -0.389242677076138 0.229517873289865 MirTarget;miRanda -0.105080246885308 0.00100529890713538 NA NA NA hsa-miR-3913-5p BTRC 0.145645056779437 0.734844256690741 -0.389242677076138 0.229517873289865 mirMAP -0.160514640592341 0.000175552950437538 NA NA NA hsa-miR-505-3p BTRC 0.58881333170866 0.226937454637888 -0.389242677076138 0.229517873289865 MirTarget -0.103932436230113 0.00591974191859582 NA NA NA hsa-miR-10a-5p CAMK2A -0.482300926520507 0.594608783320466 -4.61067365401457 0.000101073851621997 mirMAP -0.420794719642766 1.01305937838495e-08 NA NA NA hsa-miR-130b-5p CAMK2A 3.74118449312296 2.92266550966038e-10 -4.61067365401457 0.000101073851621997 mirMAP -0.55410496328163 4.56734557457472e-07 NA NA NA hsa-miR-148b-5p CAMK2A 2.80812018666078 3.97536665756679e-08 -4.61067365401457 0.000101073851621997 mirMAP -0.36341828117092 0.00552462088359509 NA NA NA hsa-miR-15b-3p CAMK2A 3.57530146629867 5.89922785773482e-11 -4.61067365401457 0.000101073851621997 mirMAP -0.371629816235669 0.00210186189548789 NA NA NA hsa-miR-19b-1-5p CAMK2A 1.51335451095424 0.0014717605268143 -4.61067365401457 0.000101073851621997 mirMAP -0.384132315859022 0.00728267982533681 NA NA NA hsa-miR-25-3p CAMK2A 1.12623030168869 0.00311079344417173 -4.61067365401457 0.000101073851621997 MirTarget -0.822145181684791 4.06664429175661e-06 NA NA NA hsa-miR-30a-5p CAMK2A -0.768430903969183 0.320487552854215 -4.61067365401457 0.000101073851621997 mirMAP -0.256941624107436 0.00344554944097223 NA NA NA hsa-miR-30d-5p CAMK2A 0.302504510257496 0.380193536606962 -4.61067365401457 0.000101073851621997 mirMAP -0.781249742477655 9.72613411407572e-05 NA NA NA hsa-miR-30e-5p CAMK2A 0.780047227271616 0.0346714425913016 -4.61067365401457 0.000101073851621997 mirMAP -0.492300827566032 0.00851183958796349 NA NA NA hsa-miR-32-5p CAMK2A 2.93035124381469 5.00149131394151e-10 -4.61067365401457 0.000101073851621997 MirTarget -0.383335742869611 0.00665637714187399 NA NA NA hsa-miR-338-3p CAMK2A 0.447551118940466 0.558485097370031 -4.61067365401457 0.000101073851621997 miRNATAP -0.265862011396483 0.002771828861227 NA NA NA hsa-miR-361-3p CAMK2A 0.805698609170807 0.0418491665498322 -4.61067365401457 0.000101073851621997 mirMAP -0.683138676080587 7.7163226253072e-05 NA NA NA hsa-miR-363-3p CAMK2A 4.27232887548977 8.53979362839458e-06 -4.61067365401457 0.000101073851621997 MirTarget -0.421857173981953 5.69198336143035e-10 NA NA NA hsa-miR-3913-5p CAMK2A 0.145645056779437 0.734844256690741 -4.61067365401457 0.000101073851621997 mirMAP -0.460766430743198 0.00399783001682156 NA NA NA hsa-miR-429 CAMK2A 6.39965293994036 1.96920201593608e-18 -4.61067365401457 0.000101073851621997 miRNATAP -0.599892636704134 1.46991676363009e-12 NA NA NA hsa-miR-616-5p CAMK2A 2.48416313933027 0.00318247475868827 -4.61067365401457 0.000101073851621997 mirMAP -0.436573204673853 1.21047015450171e-05 NA NA NA hsa-miR-625-5p CAMK2A 2.02792641909347 0.000935142379948297 -4.61067365401457 0.000101073851621997 mirMAP -0.458078810299952 3.37229664293953e-05 NA NA NA hsa-miR-7-1-3p CAMK2A 1.43074343339835 0.00471215970502094 -4.61067365401457 0.000101073851621997 MirTarget -0.370795412070839 0.00584126162476116 NA NA NA hsa-miR-92a-3p CAMK2A 1.87892405805529 1.27013821556583e-05 -4.61067365401457 0.000101073851621997 MirTarget -0.41072175784963 0.00917518238950801 NA NA NA hsa-miR-92b-3p CAMK2A 1.69303761469782 0.0103484911955574 -4.61067365401457 0.000101073851621997 MirTarget -0.455330197705722 7.54835153632853e-06 NA NA NA hsa-miR-29a-3p CAMK2B -0.638239697975974 0.251923581881716 1.67147225416157 0.24792776697611 mirMAP -0.45802934441659 0.00193384833829684 NA NA NA hsa-miR-29b-3p CAMK2B 0.666547117072858 0.234055379278093 1.67147225416157 0.24792776697611 mirMAP -0.451563574061045 0.00211633631251574 NA NA NA hsa-miR-139-5p CAMK2D -2.09475477693654 0.000382570602748311 -0.436236695859307 0.415730908577409 PITA;miRanda -0.170076594620179 0.000849556884477263 NA NA NA hsa-miR-197-3p CAMK2D 1.23723883665376 0.0073292027020411 -0.436236695859307 0.415730908577409 miRNATAP -0.198412063891944 0.00262366830550097 NA NA NA hsa-miR-217 CAMK2D -0.378397407994341 0.717408682071252 -0.436236695859307 0.415730908577409 miRanda -0.1026380481751 0.000406136865826072 NA NA NA hsa-miR-27a-3p CAMK2D 1.76094007417453 0.000216137556256765 -0.436236695859307 0.415730908577409 miRNATAP -0.183195442053396 0.0039502081301884 NA NA NA hsa-miR-30a-5p CAMK2D -0.768430903969183 0.320487552854215 -0.436236695859307 0.415730908577409 miRNATAP -0.10893303041019 0.00545078826629344 NA NA NA hsa-miR-30b-5p CAMK2D 0.0238659735605804 0.953223658270319 -0.436236695859307 0.415730908577409 miRNATAP -0.209196435811538 0.00568550193602901 NA NA NA hsa-miR-30c-5p CAMK2D 0.38723991118075 0.348605235643473 -0.436236695859307 0.415730908577409 miRNATAP -0.211788022743028 0.00440299858375001 NA NA NA hsa-miR-32-3p CAMK2D 2.20477794939766 0.0392771274032852 -0.436236695859307 0.415730908577409 mirMAP -0.204158627980238 3.79938884300681e-05 NA NA NA hsa-miR-320b CAMK2D 0.20205459771295 0.727216419960509 -0.436236695859307 0.415730908577409 miRanda -0.137284767408159 0.00910680545026566 NA NA NA hsa-miR-484 CAMK2D 1.79050445056016 0.000217287101253701 -0.436236695859307 0.415730908577409 miRNAWalker2_validate -0.185983159125907 0.00289263237335324 NA NA NA hsa-miR-582-5p CAMK2D 0.685177900016753 0.447761540297692 -0.436236695859307 0.415730908577409 mirMAP -0.215531600574554 3.79586190267961e-11 NA NA NA hsa-miR-107 CAMK2G 1.49443409571439 0.000130594521065411 -0.697211520072334 0.0283570720291188 miRNATAP -0.120868237018994 0.00894743846200391 NA NA NA hsa-miR-181a-5p CAMK2G 1.25558293560636 0.00748975499703878 -0.697211520072334 0.0283570720291188 miRNATAP -0.176433766908084 3.44432421400082e-06 NA NA NA hsa-miR-181b-5p CAMK2G 1.11397227523501 0.0273417050354018 -0.697211520072334 0.0283570720291188 miRNATAP -0.184358369729924 1.59425088906457e-07 NA NA NA hsa-miR-181c-5p CAMK2G -0.302833440762172 0.537532549455539 -0.697211520072334 0.0283570720291188 miRNATAP -0.134228962152357 0.000257447525525637 NA NA NA hsa-miR-484 CAMK2G 1.79050445056016 0.000217287101253701 -0.697211520072334 0.0283570720291188 mirMAP -0.107696026923104 0.00362026376984953 NA NA NA hsa-miR-628-5p CAMK2G 1.04832355434705 0.0252368809675445 -0.697211520072334 0.0283570720291188 MirTarget;PITA;miRNATAP -0.174490124142303 5.05586268618289e-06 NA NA NA hsa-let-7a-5p CCND1 0.148081801547773 0.645305441523746 0.153161422157864 0.87752763573474 TargetScan;miRNATAP -0.543758028087025 0.00245174452713361 NA NA NA hsa-miR-106a-5p CCND1 3.98693608217557 9.37722470816656e-07 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.430943892321887 6.82894757639655e-11 NA NA NA hsa-miR-15a-5p CCND1 2.0535411006904 1.91108976398046e-06 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.345671894500985 0.00776019225008181 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 3.32329949959268 8.40210501034588e-13 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.423468924188888 0.000292921876666624 NA NA NA hsa-miR-20b-5p CCND1 4.5662923200279 4.75238200639144e-05 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.306916825629866 1.73283870424345e-10 NA NA NA hsa-miR-34a-5p CCND1 0.830377770217786 0.0477544831885907 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;miRNATAP -0.423813778518534 0.00174350326234822 25792709;21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a ; liver cancer;breast cancer hsa-miR-497-5p CCND1 -1.44150596209372 0.0225146607606395 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.249933846887954 0.00498383887238102 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-106a-5p CCND2 3.98693608217557 9.37722470816656e-07 -2.81051675901102 0.00139983736368543 miRNATAP -0.444958981451041 2.08537025757115e-14 NA NA NA hsa-miR-106b-5p CCND2 2.80565545918114 1.14547999022566e-09 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309595760343179 0.00374413339981401 NA NA NA hsa-miR-10a-3p CCND2 0.970411431936568 0.31667483998251 -2.81051675901102 0.00139983736368543 mirMAP -0.203238239783698 0.000109626077062705 NA NA NA hsa-miR-130b-5p CCND2 3.74118449312296 2.92266550966038e-10 -2.81051675901102 0.00139983736368543 mirMAP -0.460499923117218 1.14695292180331e-08 NA NA NA hsa-miR-141-3p CCND2 7.30474126597325 1.45115996357606e-24 -2.81051675901102 0.00139983736368543 MirTarget;TargetScan -0.239696704303332 0.000205435786708848 NA NA NA hsa-miR-15b-5p CCND2 3.32329949959268 8.40210501034588e-13 -2.81051675901102 0.00139983736368543 miRNATAP -0.527059068245043 3.31921597840683e-07 NA NA NA hsa-miR-16-2-3p CCND2 3.79845098071094 1.49120139344659e-13 -2.81051675901102 0.00139983736368543 mirMAP -0.289719520581 0.00206680066165107 NA NA NA hsa-miR-182-5p CCND2 5.86988712704738 1.22411588571584e-15 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.278474368736704 1.61949004264047e-05 NA NA NA hsa-miR-183-5p CCND2 6.61903249270777 1.00958881445636e-16 -2.81051675901102 0.00139983736368543 miRNATAP -0.288028240113034 1.0097840608077e-06 NA NA NA hsa-miR-191-5p CCND2 1.58824208483839 0.000738859004053681 -2.81051675901102 0.00139983736368543 MirTarget -0.315151097931825 0.00313941450228982 NA NA NA hsa-miR-200a-3p CCND2 6.336081120041 4.024313571871e-16 -2.81051675901102 0.00139983736368543 MirTarget -0.414829241668513 2.52639559759353e-12 NA NA NA hsa-miR-20b-5p CCND2 4.5662923200279 4.75238200639144e-05 -2.81051675901102 0.00139983736368543 miRNATAP -0.295383995634395 4.37719472717441e-12 NA NA NA hsa-miR-224-3p CCND2 2.84876340814503 0.000179138399939161 -2.81051675901102 0.00139983736368543 mirMAP -0.216162489376406 0.00100829595274067 NA NA NA hsa-miR-28-5p CCND2 -0.815636722979196 0.0221199948901761 -2.81051675901102 0.00139983736368543 miRanda -0.428938814049462 0.00272604774130058 NA NA NA hsa-miR-3065-3p CCND2 1.89496019576082 0.0308154823923145 -2.81051675901102 0.00139983736368543 MirTarget;miRNATAP -0.206941274598462 0.000265009133802388 NA NA NA hsa-miR-3065-5p CCND2 2.14185373842821 0.0609400502269891 -2.81051675901102 0.00139983736368543 mirMAP -0.198616424838265 0.000257635954140166 NA NA NA hsa-miR-30d-3p CCND2 -0.0740421896025512 0.857423650167556 -2.81051675901102 0.00139983736368543 mirMAP -0.548341190913964 7.47249707616609e-06 NA NA NA hsa-miR-324-3p CCND2 1.51345381556672 0.0038447546677657 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate -0.43719832262749 4.09891269304966e-06 NA NA NA hsa-miR-33a-3p CCND2 2.06269680799532 0.00156436055383943 -2.81051675901102 0.00139983736368543 MirTarget -0.270924955791957 0.000410846654094401 NA NA NA hsa-miR-378a-3p CCND2 1.46612141870273 0.0466660641196872 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate -0.186901666998984 0.00600686499792038 NA NA NA hsa-miR-429 CCND2 6.39965293994036 1.96920201593608e-18 -2.81051675901102 0.00139983736368543 miRNATAP -0.457780562605429 2.24817157133262e-13 NA NA NA hsa-miR-497-5p CCND2 -1.44150596209372 0.0225146607606395 -2.81051675901102 0.00139983736368543 MirTarget;miRNATAP -0.272420525595686 0.000579324260115001 NA NA NA hsa-miR-550a-5p CCND2 1.21781238856895 0.0613791144699551 -2.81051675901102 0.00139983736368543 MirTarget -0.224646283844048 0.00363403467531415 NA NA NA hsa-miR-660-5p CCND2 -0.0668683798854808 0.885250178390404 -2.81051675901102 0.00139983736368543 mirMAP -0.290960137515711 0.00793054638018279 NA NA NA hsa-miR-9-3p CCND2 1.69328215716742 0.125170982657059 -2.81051675901102 0.00139983736368543 MirTarget;mirMAP;miRNATAP -0.143162485603445 0.00185116011719342 NA NA NA hsa-miR-93-5p CCND2 2.65964181833033 2.58315947526774e-08 -2.81051675901102 0.00139983736368543 miRNATAP -0.48060449639845 2.62594110203289e-06 NA NA NA hsa-miR-96-5p CCND2 5.62521466029286 1.54938806718028e-10 -2.81051675901102 0.00139983736368543 TargetScan;miRNATAP -0.24395409924335 0.000303822796805944 NA NA NA hsa-miR-27b-3p CCND3 -0.0929089601968123 0.85847352206581 -0.53759657598867 0.124370433214632 miRNAWalker2_validate -0.141758210053908 0.000190546260809965 NA NA NA hsa-miR-429 CCND3 6.39965293994036 1.96920201593608e-18 -0.53759657598867 0.124370433214632 miRNATAP -0.112877673525875 7.62633278325715e-06 NA NA NA hsa-miR-96-5p CCND3 5.62521466029286 1.54938806718028e-10 -0.53759657598867 0.124370433214632 TargetScan -0.116905111437921 9.66017245986979e-06 NA NA NA hsa-miR-582-5p CHP2 0.685177900016753 0.447761540297692 1.48109800587141 0.509563690322669 miRNATAP -0.415938249783453 0.0031281915626761 NA NA NA hsa-miR-21-3p CREBBP 3.50297439576639 6.39946844099206e-10 -0.3958302023172 0.180670093990074 MirTarget -0.1378273582574 1.08112070034993e-06 NA NA NA hsa-miR-590-3p CREBBP 2.35429565068338 2.79601879608564e-06 -0.3958302023172 0.180670093990074 PITA;miRanda;mirMAP;miRNATAP -0.100352894791816 0.00219317602458258 NA NA NA hsa-miR-186-5p CSNK1A1 0.445443449112564 0.185447310527704 0.245408374500098 0.395572169059955 miRNAWalker2_validate;miRNATAP -0.193913704202309 7.79674302869086e-05 NA NA NA hsa-miR-30a-5p CSNK1A1 -0.768430903969183 0.320487552854215 0.245408374500098 0.395572169059955 MirTarget;miRNATAP -0.135041314174073 3.59236678762335e-11 NA NA NA hsa-miR-7-1-3p CSNK1A1 1.43074343339835 0.00471215970502094 0.245408374500098 0.395572169059955 mirMAP -0.120672027161425 0.000159669158986854 NA NA NA hsa-miR-125a-5p CSNK2A1 -1.32352790615388 0.00714301627309467 0.48381180381159 0.0913360923034785 MirTarget;PITA;miRanda -0.108571262854327 0.000935806228856506 NA NA NA hsa-miR-342-3p CTBP2 1.31107714473009 0.0207211910724662 -0.534858240246571 0.121949363819826 MirTarget;PITA;miRanda;miRNATAP -0.126298130193261 0.000232764023108101 NA NA NA hsa-miR-150-5p CTNNB1 1.76769157530064 0.0593795975117846 -0.598740867811971 0.152216124887482 MirTarget -0.1161821301588 2.89988026655084e-06 NA NA NA hsa-miR-155-5p CTNNB1 2.81443182173772 7.42530504828797e-05 -0.598740867811971 0.152216124887482 miRNAWalker2_validate -0.166081896357714 3.05605612118335e-07 NA NA NA hsa-miR-221-3p CTNNB1 0.94082283577318 0.174749164179978 -0.598740867811971 0.152216124887482 miRNAWalker2_validate -0.15386110666748 5.20471332163171e-06 NA NA NA hsa-miR-330-3p CTNNB1 2.49094236945806 0.000129367003214715 -0.598740867811971 0.152216124887482 MirTarget;PITA;miRNATAP -0.113866447624475 0.00159137187547744 NA NA NA hsa-miR-590-3p CTNNB1 2.35429565068338 2.79601879608564e-06 -0.598740867811971 0.152216124887482 miRanda -0.159536768797246 0.00059253265161602 NA NA NA hsa-miR-10a-5p CTNNBIP1 -0.482300926520507 0.594608783320466 1.03005539288975 0.0177273867076639 miRNATAP -0.126697371710711 2.36218282426033e-06 NA NA NA hsa-miR-125a-3p CTNNBIP1 -0.0748960586927341 0.920735897434087 1.03005539288975 0.0177273867076639 miRanda -0.170413612828531 1.31498706666802e-07 NA NA NA hsa-miR-125a-5p CTNNBIP1 -1.32352790615388 0.00714301627309467 1.03005539288975 0.0177273867076639 mirMAP -0.187649059978902 0.00017266028748789 NA NA NA hsa-miR-192-5p CTNNBIP1 1.77716187978541 0.113485496183047 1.03005539288975 0.0177273867076639 miRNAWalker2_validate;MirTarget;miRNATAP -0.132175883814956 5.67049965084063e-10 NA NA NA hsa-miR-215-5p CTNNBIP1 3.66990923176752 0.00294614570694381 1.03005539288975 0.0177273867076639 miRNAWalker2_validate;MirTarget -0.100891368557812 2.29881480994223e-07 NA NA NA hsa-miR-335-5p CTNNBIP1 0.167216045757305 0.803897055331049 1.03005539288975 0.0177273867076639 miRNAWalker2_validate;mirMAP -0.15744834958761 1.48207299376159e-05 NA NA NA hsa-miR-505-5p CTNNBIP1 -0.548246528900629 0.331409094367131 1.03005539288975 0.0177273867076639 MirTarget -0.12792172445794 0.00351604379386236 NA NA NA hsa-miR-625-5p CTNNBIP1 2.02792641909347 0.000935142379948297 1.03005539288975 0.0177273867076639 mirMAP -0.120181043685081 0.00286205398441888 NA NA NA hsa-miR-92b-3p CTNNBIP1 1.69303761469782 0.0103484911955574 1.03005539288975 0.0177273867076639 miRNATAP -0.200586456269185 4.0720456477811e-08 NA NA NA hsa-let-7g-3p DAAM1 2.09736290930341 5.30067796437833e-05 0.276570533956138 0.675263432310241 MirTarget -0.297254323759927 2.83072967462045e-05 NA NA NA hsa-miR-125a-5p DAAM1 -1.32352790615388 0.00714301627309467 0.276570533956138 0.675263432310241 MirTarget -0.275633109591266 0.000276738430676473 NA NA NA hsa-miR-181c-5p DAAM1 -0.302833440762172 0.537532549455539 0.276570533956138 0.675263432310241 mirMAP -0.259662296598169 0.000684412511064248 NA NA NA hsa-miR-186-5p DAAM1 0.445443449112564 0.185447310527704 0.276570533956138 0.675263432310241 MirTarget;mirMAP -0.542676564610488 1.31439489133088e-06 NA NA NA hsa-miR-194-5p DAAM1 0.691219038144468 0.523143086635506 0.276570533956138 0.675263432310241 miRNATAP -0.171266373999645 4.52372161332232e-07 NA NA NA hsa-miR-29b-3p DAAM1 0.666547117072858 0.234055379278093 0.276570533956138 0.675263432310241 MirTarget;miRNATAP -0.192846740572908 0.00397875371633019 NA NA NA hsa-miR-29c-3p DAAM1 -0.414153610337085 0.529344128062017 0.276570533956138 0.675263432310241 MirTarget;miRNATAP -0.158827295076248 0.00523060177652306 NA NA NA hsa-miR-32-5p DAAM1 2.93035124381469 5.00149131394151e-10 0.276570533956138 0.675263432310241 miRNATAP -0.218491380893966 0.004856799210676 NA NA NA hsa-miR-335-5p DAAM1 0.167216045757305 0.803897055331049 0.276570533956138 0.675263432310241 miRNAWalker2_validate;MirTarget;miRNATAP -0.190183727710072 0.000600904552801714 NA NA NA hsa-miR-34a-5p DAAM1 0.830377770217786 0.0477544831885907 0.276570533956138 0.675263432310241 MirTarget;miRNATAP -0.325853056210634 0.000276123613355551 NA NA NA hsa-miR-362-3p DAAM1 0.679952485897744 0.226148468488576 0.276570533956138 0.675263432310241 MirTarget;miRanda;miRNATAP -0.214862898719501 0.00131317919934595 NA NA NA hsa-miR-454-3p DAAM1 1.40269869979902 0.00366085847011367 0.276570533956138 0.675263432310241 MirTarget;miRNATAP -0.241034433328455 0.00185755336403306 NA NA NA hsa-miR-590-3p DAAM1 2.35429565068338 2.79601879608564e-06 0.276570533956138 0.675263432310241 MirTarget;miRanda;mirMAP -0.2443961632374 0.000873002406433808 NA NA NA hsa-miR-92b-3p DAAM1 1.69303761469782 0.0103484911955574 0.276570533956138 0.675263432310241 miRNATAP -0.177936379756159 0.00158344292711636 NA NA NA hsa-miR-141-5p DAAM2 7.13744624551943 4.06877058732583e-26 -4.26053553183336 8.29673298827332e-06 mirMAP -0.570696163982686 1.46055145639665e-15 NA NA NA hsa-miR-182-5p DAAM2 5.86988712704738 1.22411588571584e-15 -4.26053553183336 8.29673298827332e-06 mirMAP -0.207255779338193 0.00365677570338477 NA NA NA hsa-miR-18a-5p DAAM2 3.90770175770219 9.15298615034137e-10 -4.26053553183336 8.29673298827332e-06 miRNAWalker2_validate -0.307828697056098 0.000227514437839013 NA NA NA hsa-miR-193a-3p DAAM2 0.646392169474854 0.207134343676122 -4.26053553183336 8.29673298827332e-06 miRanda -0.49295339375629 3.95496864969965e-06 NA NA NA hsa-miR-1976 DAAM2 3.27217274919653 3.16337235854532e-12 -4.26053553183336 8.29673298827332e-06 mirMAP -0.552551233273318 8.55297658334893e-07 NA NA NA hsa-miR-205-5p DAAM2 8.08298115900323 3.83045179398654e-07 -4.26053553183336 8.29673298827332e-06 mirMAP -0.188663285143127 1.15811050103557e-08 NA NA NA hsa-miR-339-5p DAAM2 1.23326828594484 0.0307501214818698 -4.26053553183336 8.29673298827332e-06 miRanda -0.404277523636253 2.39445351225706e-05 NA NA NA hsa-miR-361-3p DAAM2 0.805698609170807 0.0418491665498322 -4.26053553183336 8.29673298827332e-06 mirMAP -0.672224247551321 1.30348412242707e-06 NA NA NA hsa-miR-429 DAAM2 6.39965293994036 1.96920201593608e-18 -4.26053553183336 8.29673298827332e-06 miRNATAP -0.231093435020544 0.00109269266179537 NA NA NA hsa-miR-590-3p DAAM2 2.35429565068338 2.79601879608564e-06 -4.26053553183336 8.29673298827332e-06 miRanda;mirMAP -0.584835747939958 3.92624647177008e-08 NA NA NA hsa-miR-193a-3p DKK2 0.646392169474854 0.207134343676122 -1.67695241592961 0.165352633703973 miRanda -0.657128532340711 7.59835105511743e-07 NA NA NA hsa-miR-221-3p DKK2 0.94082283577318 0.174749164179978 -1.67695241592961 0.165352633703973 miRNAWalker2_validate;miRTarBase -0.274741130773507 0.00550784821701667 NA NA NA hsa-miR-27a-3p DKK2 1.76094007417453 0.000216137556256765 -1.67695241592961 0.165352633703973 miRNATAP -0.673957157945868 2.11730971088654e-06 NA NA NA hsa-miR-33a-3p DKK2 2.06269680799532 0.00156436055383943 -1.67695241592961 0.165352633703973 mirMAP -0.28395098081343 0.00692346131639689 NA NA NA hsa-miR-486-5p DKK2 1.10898145177457 0.309287974401609 -1.67695241592961 0.165352633703973 miRanda;miRNATAP -0.187952045051441 0.00269369273726781 NA NA NA hsa-miR-590-5p DKK2 1.51400888103768 0.0023888567923017 -1.67695241592961 0.165352633703973 miRanda -0.434105282780938 0.00158369991842918 NA NA NA hsa-miR-944 DKK2 7.20925181386398 0.000823207457340648 -1.67695241592961 0.165352633703973 mirMAP -0.147923599569798 0.000146766558529192 NA NA NA hsa-miR-335-5p DKK4 0.167216045757305 0.803897055331049 1.37274467499535 0.386108555859798 miRNAWalker2_validate -0.622243538154658 2.47277624073016e-06 NA NA NA hsa-miR-10a-5p DVL1 -0.482300926520507 0.594608783320466 0.0930830936484925 0.802605048970877 miRNAWalker2_validate -0.11026504710669 1.40870159993299e-06 NA NA NA hsa-miR-125a-5p DVL3 -1.32352790615388 0.00714301627309467 0.712696667163076 0.0441831929271895 PITA -0.114291084779072 0.00510375398533769 NA NA NA hsa-miR-146b-3p DVL3 1.34608871980101 0.00935728391852709 0.712696667163076 0.0441831929271895 MirTarget -0.152558917031062 7.36274039601236e-05 NA NA NA hsa-miR-29b-2-5p DVL3 -0.596051745078872 0.189540844841389 0.712696667163076 0.0441831929271895 MirTarget -0.119308522306106 0.00736926175410278 NA NA NA hsa-miR-30a-3p DVL3 -1.22212086897848 0.167565797592104 0.712696667163076 0.0441831929271895 MirTarget -0.122406816743673 3.30206813290696e-08 NA NA NA hsa-miR-148a-3p EP300 1.1031350648218 0.052038169812979 0.224331914964019 0.578934208058052 miRNATAP -0.104185690998739 0.00975228544208279 NA NA NA hsa-miR-30c-5p EP300 0.38723991118075 0.348605235643473 0.224331914964019 0.578934208058052 miRNAWalker2_validate -0.18542784496307 0.000897194160521004 NA NA NA hsa-miR-339-5p EP300 1.23326828594484 0.0307501214818698 0.224331914964019 0.578934208058052 miRanda -0.199156483102611 4.47682764951844e-07 NA NA NA hsa-miR-342-3p EP300 1.31107714473009 0.0207211910724662 0.224331914964019 0.578934208058052 MirTarget;PITA;miRanda;miRNATAP -0.115722711407846 0.00406603413994019 NA NA NA hsa-miR-374b-5p EP300 -0.114749866169918 0.764888930049438 0.224331914964019 0.578934208058052 mirMAP;miRNATAP -0.159199926258203 0.00855691297646884 NA NA NA hsa-miR-590-3p EP300 2.35429565068338 2.79601879608564e-06 0.224331914964019 0.578934208058052 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.136964991854083 0.00229030845745203 NA NA NA hsa-miR-148b-3p FBXW11 1.75622244535669 8.84414356040579e-08 -0.558881503264246 0.0547787087394548 miRNAWalker2_validate -0.137834010500419 0.00589089218467001 NA NA NA hsa-miR-331-3p FBXW11 2.60769294751513 3.84318952029483e-07 -0.558881503264246 0.0547787087394548 miRNATAP -0.103415497025069 0.00100190758728944 NA NA NA hsa-miR-374b-5p FBXW11 -0.114749866169918 0.764888930049438 -0.558881503264246 0.0547787087394548 mirMAP -0.131824038103188 0.00241540705330138 NA NA NA hsa-miR-590-3p FBXW11 2.35429565068338 2.79601879608564e-06 -0.558881503264246 0.0547787087394548 mirMAP -0.101190816629317 0.00171731927469691 NA NA NA hsa-miR-34a-5p FOSL1 0.830377770217786 0.0477544831885907 2.10358791044215 0.0497968487699577 miRNAWalker2_validate;miRTarBase -0.395916583554062 0.00700648816785535 22198213;23001043 MicroRNA 34a inhibits migration and invasion of colon cancer cells via targeting to Fra 1; Here we identified Fra-1 as a new target of miR-34a and demonstrated that miR-34a inhibits Fra-1 expression at both protein and messenger RNA levels; Overexpression of miR-34a strongly inhibited colon cancer cell migration and invasion which can be partially rescued by forced expression of the Fra-1 transcript lacking the 3'-untranslated region;Moreover significant downregulation of miR-34a in metastatic breast cancer tissues was found to be inversely correlated with Fra-1 expression; Our results demonstrate that miR-34a/c functions as a metastasis suppressor to regulate breast cancer migration and invasion through targeting Fra-1 oncogene and suggest a therapeutic application of miR-34 in breast cancer cell migration;metastasis colon cancer;breast cancer hsa-miR-454-3p FOSL1 1.40269869979902 0.00366085847011367 2.10358791044215 0.0497968487699577 MirTarget -0.339122687493332 0.00737228376919168 NA NA NA hsa-miR-130a-5p FRAT1 1.58028512890005 0.024346333013728 -0.419842156082442 0.342841896838572 miRNATAP -0.100178156665785 0.00567186145941396 NA NA NA hsa-miR-22-3p FRAT2 0.845430028554782 0.0148923883819448 1.3647650151325 0.000947277064166433 miRNAWalker2_validate;MirTarget;miRNATAP -0.265227851027296 0.000107912254541356 NA NA NA hsa-miR-146b-5p FZD1 1.87569569182453 0.000737241069698886 -0.318491374654607 0.491789959368398 MirTarget;PITA;miRanda -0.12122238704442 0.00988542294343242 NA NA NA hsa-miR-29a-3p FZD1 -0.638239697975974 0.251923581881716 -0.318491374654607 0.491789959368398 mirMAP -0.171333710769929 0.00026723836872456 NA NA NA hsa-miR-29b-3p FZD1 0.666547117072858 0.234055379278093 -0.318491374654607 0.491789959368398 mirMAP -0.223781902211902 1.38655813660173e-06 NA NA NA hsa-miR-590-3p FZD1 2.35429565068338 2.79601879608564e-06 -0.318491374654607 0.491789959368398 miRanda -0.178450935504682 0.000518778693117224 NA NA NA hsa-miR-335-5p FZD10 0.167216045757305 0.803897055331049 0.817127632737711 0.546902427216764 miRNAWalker2_validate -0.32447150664636 0.0045590174989641 NA NA NA hsa-miR-92b-3p FZD10 1.69303761469782 0.0103484911955574 0.817127632737711 0.546902427216764 miRNATAP -0.408813919349178 0.000408188212271156 NA NA NA hsa-let-7b-3p FZD3 0.589364128513318 0.200507534602851 -2.2712968833062 0.0197819973302092 MirTarget;miRNATAP -0.391775229422405 0.00123397253469845 NA NA NA hsa-let-7b-5p FZD3 -0.189422992330471 0.651878220048983 -2.2712968833062 0.0197819973302092 MirTarget;miRNATAP -0.400834438580578 0.00271706179103384 NA NA NA hsa-let-7f-1-3p FZD3 1.61507869803314 0.00069342464777815 -2.2712968833062 0.0197819973302092 MirTarget -0.31298120278851 0.00751255516333369 NA NA NA hsa-miR-142-3p FZD3 4.35304505457969 3.10014573651358e-10 -2.2712968833062 0.0197819973302092 miRanda -0.335676063800471 1.33860192234743e-05 NA NA NA hsa-miR-146a-5p FZD3 2.64646698525354 0.000280611928973036 -2.2712968833062 0.0197819973302092 MirTarget -0.373068677777254 5.20415294434459e-07 NA NA NA hsa-miR-155-5p FZD3 2.81443182173772 7.42530504828797e-05 -2.2712968833062 0.0197819973302092 mirMAP -0.359934463087244 2.38470974855901e-06 NA NA NA hsa-miR-16-1-3p FZD3 2.83281226969693 7.54359864580834e-09 -2.2712968833062 0.0197819973302092 mirMAP -0.319820172643704 0.00394897878069372 NA NA NA hsa-miR-16-2-3p FZD3 3.79845098071094 1.49120139344659e-13 -2.2712968833062 0.0197819973302092 mirMAP -0.313624624836376 0.00252529278231522 NA NA NA hsa-miR-205-5p FZD3 8.08298115900323 3.83045179398654e-07 -2.2712968833062 0.0197819973302092 MirTarget -0.168834170318472 4.72789797910524e-07 25521201 Our data analysis also showed that miR-98 and miR-205 have two common predicted target genes FZD3 and RPS6KA3 which are actually genes associated with carcinoma according to the Online Mendelian Inheritance in Man OMIM database lung squamous cell cancer hsa-miR-23b-3p FZD3 -0.581135273821923 0.190478897170459 -2.2712968833062 0.0197819973302092 MirTarget -0.421924654848594 0.000798515248907007 NA NA NA hsa-miR-27b-3p FZD3 -0.0929089601968123 0.85847352206581 -2.2712968833062 0.0197819973302092 miRNATAP -0.372976594023668 0.000477589576040137 NA NA NA hsa-miR-342-3p FZD3 1.31107714473009 0.0207211910724662 -2.2712968833062 0.0197819973302092 miRanda -0.295682048421979 0.00249712798748224 NA NA NA hsa-miR-452-3p FZD3 2.97956996345436 0.000203580834647624 -2.2712968833062 0.0197819973302092 MirTarget -0.222632262971689 0.00114068931063861 NA NA NA hsa-miR-452-5p FZD3 2.45466810475361 0.00114794259949532 -2.2712968833062 0.0197819973302092 mirMAP -0.327172010172874 5.73268775022015e-06 NA NA NA hsa-miR-944 FZD3 7.20925181386398 0.000823207457340648 -2.2712968833062 0.0197819973302092 MirTarget;PITA;miRNATAP -0.201675798691389 5.69788087904236e-11 NA NA NA hsa-let-7a-3p FZD4 0.82512001802525 0.0468122405194487 -2.83886953461754 3.72732903465121e-05 mirMAP -0.289191281655542 0.00261784404358226 NA NA NA hsa-let-7b-3p FZD4 0.589364128513318 0.200507534602851 -2.83886953461754 3.72732903465121e-05 mirMAP -0.229269440598043 0.00813497276382615 NA NA NA hsa-let-7b-5p FZD4 -0.189422992330471 0.651878220048983 -2.83886953461754 3.72732903465121e-05 MirTarget;miRNATAP -0.275360310596682 0.00386154408558111 NA NA NA hsa-let-7f-1-3p FZD4 1.61507869803314 0.00069342464777815 -2.83886953461754 3.72732903465121e-05 mirMAP -0.271909202878902 0.00107897881690323 NA NA NA hsa-miR-141-3p FZD4 7.30474126597325 1.45115996357606e-24 -2.83886953461754 3.72732903465121e-05 TargetScan -0.146207262935211 0.00415064235917507 NA NA NA hsa-miR-150-5p FZD4 1.76769157530064 0.0593795975117846 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.131035747829938 0.00176171330583994 NA NA NA hsa-miR-15b-5p FZD4 3.32329949959268 8.40210501034588e-13 -2.83886953461754 3.72732903465121e-05 MirTarget -0.282999459031275 0.000569874909623984 NA NA NA hsa-miR-16-5p FZD4 2.93575808220754 2.15436817162977e-10 -2.83886953461754 3.72732903465121e-05 MirTarget -0.227505888117745 0.00647410235924482 NA NA NA hsa-miR-200b-3p FZD4 5.56167217794639 6.43540045061709e-16 -2.83886953461754 3.72732903465121e-05 mirMAP -0.238298937559481 1.05112124811421e-05 NA NA NA hsa-miR-200c-3p FZD4 6.47012025883743 2.64500707716408e-26 -2.83886953461754 3.72732903465121e-05 mirMAP -0.233220034337669 8.01322431715165e-05 NA NA NA hsa-miR-224-3p FZD4 2.84876340814503 0.000179138399939161 -2.83886953461754 3.72732903465121e-05 MirTarget -0.28225814299032 2.87859841920122e-08 NA NA NA hsa-miR-25-3p FZD4 1.12623030168869 0.00311079344417173 -2.83886953461754 3.72732903465121e-05 mirMAP -0.316761893783551 0.00247147999129914 NA NA NA hsa-miR-27a-3p FZD4 1.76094007417453 0.000216137556256765 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.261515033149759 0.00156287118774928 NA NA NA hsa-miR-27b-3p FZD4 -0.0929089601968123 0.85847352206581 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.243490119104825 0.0013959995389089 NA NA NA hsa-miR-33a-3p FZD4 2.06269680799532 0.00156436055383943 -2.83886953461754 3.72732903465121e-05 mirMAP -0.315492579937533 1.17062941143373e-07 NA NA NA hsa-miR-429 FZD4 6.39965293994036 1.96920201593608e-18 -2.83886953461754 3.72732903465121e-05 mirMAP -0.223467585312549 9.44591820899412e-06 NA NA NA hsa-miR-452-5p FZD4 2.45466810475361 0.00114794259949532 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.314911211799412 5.04643655024212e-10 NA NA NA hsa-miR-576-5p FZD4 1.30320223793746 0.00648929463912994 -2.83886953461754 3.72732903465121e-05 mirMAP -0.216830219353013 0.00885127918136263 NA NA NA hsa-miR-590-3p FZD4 2.35429565068338 2.79601879608564e-06 -2.83886953461754 3.72732903465121e-05 miRanda;mirMAP;miRNATAP -0.229697889158717 0.00314265095609673 NA NA NA hsa-miR-629-3p FZD4 3.48282157979573 4.9176538695908e-08 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.227018116324061 0.00016531596497597 NA NA NA hsa-miR-653-5p FZD4 1.43354001460259 0.0479177174923075 -2.83886953461754 3.72732903465121e-05 MirTarget -0.16470578851558 0.0027849753448391 NA NA NA hsa-miR-708-5p FZD4 1.70409736218557 0.0319538709865338 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.193141187540541 8.78652560864314e-05 NA NA NA hsa-let-7b-3p FZD5 0.589364128513318 0.200507534602851 0.640287282353737 0.297444783437361 miRNATAP -0.205895528602781 0.00696500873050967 NA NA NA hsa-miR-155-5p FZD5 2.81443182173772 7.42530504828797e-05 0.640287282353737 0.297444783437361 miRNATAP -0.211896725721244 1.00818321655591e-05 NA NA NA hsa-miR-23a-3p FZD5 0.925125296618358 0.0127293543936914 0.640287282353737 0.297444783437361 miRNATAP -0.289711657168532 0.00225871469675491 NA NA NA hsa-miR-23b-3p FZD5 -0.581135273821923 0.190478897170459 0.640287282353737 0.297444783437361 miRNATAP -0.280347016349859 0.000379321134775307 NA NA NA hsa-miR-24-3p FZD5 1.55853749533999 0.000524726461381821 0.640287282353737 0.297444783437361 miRNAWalker2_validate;miRNATAP -0.22875330448975 0.00314726074883253 NA NA NA hsa-miR-342-3p FZD5 1.31107714473009 0.0207211910724662 0.640287282353737 0.297444783437361 PITA -0.186426276738242 0.0023834988286169 NA NA NA hsa-miR-99a-5p FZD5 -2.72139054000803 0.00621971944534118 0.640287282353737 0.297444783437361 MirTarget;miRNATAP -0.125875532977723 0.000270995390359697 NA NA NA hsa-miR-194-5p FZD6 0.691219038144468 0.523143086635506 1.58130849246817 0.00919065409091848 MirTarget -0.251019560286905 1.22839454916662e-16 NA NA NA hsa-miR-142-3p FZD7 4.35304505457969 3.10014573651358e-10 -2.72325006685666 0.00150687292014913 miRanda -0.373560938656454 3.11438751908879e-08 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p cervical and endocervical cancer hsa-miR-142-5p FZD7 3.95552531913424 1.49536283724079e-08 -2.72325006685666 0.00150687292014913 MirTarget;PITA;miRNATAP -0.362955447075897 6.92115542119614e-08 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7 cervical and endocervical cancer hsa-miR-192-5p FZD7 1.77716187978541 0.113485496183047 -2.72325006685666 0.00150687292014913 miRNAWalker2_validate -0.115148199976731 0.00808053119326572 NA NA NA hsa-miR-215-5p FZD7 3.66990923176752 0.00294614570694381 -2.72325006685666 0.00150687292014913 miRNAWalker2_validate -0.128832283203823 0.00103711067552621 NA NA NA hsa-miR-330-3p FZD7 2.49094236945806 0.000129367003214715 -2.72325006685666 0.00150687292014913 mirMAP -0.278992643858465 0.000179188356936391 NA NA NA hsa-miR-338-5p FZD7 -0.108304629897487 0.894675560494607 -2.72325006685666 0.00150687292014913 MirTarget;PITA;miRNATAP -0.165566070058614 0.00594825069199063 NA NA NA hsa-miR-590-3p FZD7 2.35429565068338 2.79601879608564e-06 -2.72325006685666 0.00150687292014913 miRanda -0.403041157541026 2.56570813299877e-05 NA NA NA hsa-miR-590-3p FZD8 2.35429565068338 2.79601879608564e-06 -0.605760786756907 0.557609369330486 miRanda -0.346881927689195 0.00260365350935014 NA NA NA hsa-miR-192-5p FZD9 1.77716187978541 0.113485496183047 0.892340449420943 0.433615785945545 miRNATAP -0.269388155649398 1.93576138120715e-06 NA NA NA hsa-miR-181c-5p GSK3B -0.302833440762172 0.537532549455539 0.984264794042029 0.00614784819440891 mirMAP -0.115369483842179 0.00582165998524454 NA NA NA hsa-miR-30a-3p GSK3B -1.22212086897848 0.167565797592104 0.984264794042029 0.00614784819440891 miRNATAP -0.11517576765646 3.57050461951731e-07 NA NA NA hsa-miR-30d-3p GSK3B -0.0740421896025512 0.857423650167556 0.984264794042029 0.00614784819440891 miRNATAP -0.217356687168476 1.21966436788369e-05 NA NA NA hsa-miR-320c GSK3B -0.10618808730545 0.854002814666472 0.984264794042029 0.00614784819440891 miRanda;mirMAP -0.100605875350465 0.00537879672016752 NA NA NA hsa-miR-362-5p GSK3B -1.22309034685697 0.0452665543907975 0.984264794042029 0.00614784819440891 miRNATAP -0.116235509089146 0.000473661337943669 NA NA NA hsa-miR-141-3p JUN 7.30474126597325 1.45115996357606e-24 -1.39678224976456 0.0210065056705043 miRNATAP -0.140631808287642 0.00151406596577943 NA NA NA hsa-miR-30a-5p JUN -0.768430903969183 0.320487552854215 -1.39678224976456 0.0210065056705043 miRNAWalker2_validate -0.152843415788565 0.000559974108995951 NA NA NA hsa-miR-193b-3p LEF1 1.35015762547152 0.0874921379319504 -1.06801208642423 0.21098542163647 miRNAWalker2_validate -0.349322384823671 5.36528724241979e-09 NA NA NA hsa-miR-330-5p LEF1 2.25110496739954 0.000275527655397415 -1.06801208642423 0.21098542163647 miRanda -0.403439067915215 1.29300750911004e-07 NA NA NA hsa-miR-23b-3p LRP5 -0.581135273821923 0.190478897170459 -0.595959399367886 0.240924557326017 MirTarget;miRNATAP -0.218346439327815 0.000821970690502326 NA NA NA hsa-let-7a-3p LRP6 0.82512001802525 0.0468122405194487 -1.5108432620961 0.00142291856207554 miRNATAP -0.239522877911242 0.000250601301585231 NA NA NA hsa-let-7b-3p LRP6 0.589364128513318 0.200507534602851 -1.5108432620961 0.00142291856207554 miRNATAP -0.191745599906589 0.00115669494820718 NA NA NA hsa-miR-15a-5p LRP6 2.0535411006904 1.91108976398046e-06 -1.5108432620961 0.00142291856207554 miRNATAP -0.165773696022836 0.00773102096168767 NA NA NA hsa-miR-15b-3p LRP6 3.57530146629867 5.89922785773482e-11 -1.5108432620961 0.00142291856207554 mirMAP -0.126415824983402 0.0085095996610987 NA NA NA hsa-miR-16-1-3p LRP6 2.83281226969693 7.54359864580834e-09 -1.5108432620961 0.00142291856207554 mirMAP -0.230596673066301 1.66697104506246e-05 NA NA NA hsa-miR-16-2-3p LRP6 3.79845098071094 1.49120139344659e-13 -1.5108432620961 0.00142291856207554 mirMAP -0.226119881614063 6.32525687825393e-06 NA NA NA hsa-miR-16-5p LRP6 2.93575808220754 2.15436817162977e-10 -1.5108432620961 0.00142291856207554 miRNATAP -0.184141529083919 0.00122049498427303 NA NA NA hsa-miR-193a-3p LRP6 0.646392169474854 0.207134343676122 -1.5108432620961 0.00142291856207554 miRanda -0.196481989769693 0.000194121112974321 NA NA NA hsa-miR-205-5p LRP6 8.08298115900323 3.83045179398654e-07 -1.5108432620961 0.00142291856207554 miRNATAP -0.121996879175874 1.57174972800956e-14 NA NA NA hsa-miR-221-3p LRP6 0.94082283577318 0.174749164179978 -1.5108432620961 0.00142291856207554 miRNAWalker2_validate -0.337661590536743 2.94261432714232e-20 NA NA NA hsa-miR-224-3p LRP6 2.84876340814503 0.000179138399939161 -1.5108432620961 0.00142291856207554 mirMAP -0.135889711951014 0.000113019503836657 NA NA NA hsa-miR-29a-3p LRP6 -0.638239697975974 0.251923581881716 -1.5108432620961 0.00142291856207554 miRNATAP -0.209015898037184 1.46286019821099e-05 NA NA NA hsa-miR-29b-3p LRP6 0.666547117072858 0.234055379278093 -1.5108432620961 0.00142291856207554 miRNATAP -0.272342890317397 9.20343798939943e-09 NA NA NA hsa-miR-29c-3p LRP6 -0.414153610337085 0.529344128062017 -1.5108432620961 0.00142291856207554 miRNATAP -0.165154148934994 5.14844928361703e-05 NA NA NA hsa-miR-330-3p LRP6 2.49094236945806 0.000129367003214715 -1.5108432620961 0.00142291856207554 PITA;mirMAP;miRNATAP -0.135466896435882 0.000986178094432534 NA NA NA hsa-miR-590-3p LRP6 2.35429565068338 2.79601879608564e-06 -1.5108432620961 0.00142291856207554 PITA;miRanda;miRNATAP -0.271209115892361 2.21823124321968e-07 NA NA NA hsa-miR-29a-5p MAP3K7 0.0748295222568571 0.884125894063293 0.316391433469006 0.292968544589595 mirMAP -0.123297042652905 0.000192527325272211 NA NA NA hsa-miR-34a-5p MAP3K7 0.830377770217786 0.0477544831885907 0.316391433469006 0.292968544589595 miRNAWalker2_validate -0.115410514352201 0.00466228094371235 NA NA NA hsa-miR-664a-3p MAP3K7 0.249882351950296 0.56171157318348 0.316391433469006 0.292968544589595 MirTarget;mirMAP -0.129722952536066 0.00109384610601403 NA NA NA hsa-miR-130b-3p MAPK10 3.9204771543282 1.2714917955808e-11 -4.02861810775413 0.000455327611153647 miRNATAP -0.289477401545203 0.00852945933118219 NA NA NA hsa-miR-193a-3p MAPK10 0.646392169474854 0.207134343676122 -4.02861810775413 0.000455327611153647 miRanda;miRNATAP -0.422086807842181 0.00104846344400487 NA NA NA hsa-miR-19a-3p MAPK10 2.17020503944519 0.00122084653711062 -4.02861810775413 0.000455327611153647 miRNATAP -0.361656353314988 0.000189541931048248 NA NA NA hsa-miR-19b-3p MAPK10 1.67581705793313 0.000858910586302716 -4.02861810775413 0.000455327611153647 miRNATAP -0.607554128693399 2.5291087868802e-06 NA NA NA hsa-miR-301a-3p MAPK10 1.99338115332667 0.000813358604963724 -4.02861810775413 0.000455327611153647 miRNATAP -0.54512724483879 4.88085213693914e-07 NA NA NA hsa-miR-454-3p MAPK10 1.40269869979902 0.00366085847011367 -4.02861810775413 0.000455327611153647 miRNATAP -0.574589535977024 2.1903057455657e-05 NA NA NA hsa-miR-582-5p MAPK10 0.685177900016753 0.447761540297692 -4.02861810775413 0.000455327611153647 PITA -0.23346088711947 0.00130125193601691 NA NA NA hsa-miR-29a-5p MAPK8 0.0748295222568571 0.884125894063293 0.782437648754587 0.218394219235169 mirMAP -0.207086809669531 0.00336154577686051 NA NA NA hsa-miR-590-3p MMP7 2.35429565068338 2.79601879608564e-06 -3.04326127961044 0.0749319303420266 miRanda -0.499481287241256 0.00907848518433902 NA NA NA hsa-miR-590-5p MMP7 1.51400888103768 0.0023888567923017 -3.04326127961044 0.0749319303420266 miRanda -0.64908021008509 0.000837452656727188 NA NA NA hsa-miR-34a-5p MYC 0.830377770217786 0.0477544831885907 -0.745260197790044 0.453852120838847 miRNAWalker2_validate;miRTarBase -0.427487830189717 0.00161403194033986 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 6.39965293994036 1.96920201593608e-18 -0.745260197790044 0.453852120838847 miRNAWalker2_validate -0.351232938868747 9.84375821791447e-07 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-148b-5p NFAT5 2.80812018666078 3.97536665756679e-08 -0.873812260090285 0.0142802458392285 MirTarget -0.100855866248161 0.00959701643950966 NA NA NA hsa-miR-15b-3p NFAT5 3.57530146629867 5.89922785773482e-11 -0.873812260090285 0.0142802458392285 mirMAP -0.126013171880713 0.000433697196258896 NA NA NA hsa-miR-16-1-3p NFAT5 2.83281226969693 7.54359864580834e-09 -0.873812260090285 0.0142802458392285 mirMAP -0.130238828931912 0.00125292308133802 NA NA NA hsa-miR-21-3p NFAT5 3.50297439576639 6.39946844099206e-10 -0.873812260090285 0.0142802458392285 MirTarget -0.118527852125061 0.000620164790667205 NA NA NA hsa-miR-25-3p NFAT5 1.12623030168869 0.00311079344417173 -0.873812260090285 0.0142802458392285 miRNATAP -0.223695548560318 2.57174109236902e-05 NA NA NA hsa-miR-27b-5p NFAT5 0.213392605793392 0.71562473353293 -0.873812260090285 0.0142802458392285 miRNATAP -0.110179611906402 0.00144077959452122 NA NA NA hsa-miR-361-3p NFAT5 0.805698609170807 0.0418491665498322 -0.873812260090285 0.0142802458392285 MirTarget;PITA;miRNATAP -0.144768979044564 0.0050756704455289 NA NA NA hsa-miR-3613-5p NFAT5 4.05007522786126 4.52786477176299e-14 -0.873812260090285 0.0142802458392285 miRNATAP -0.104413571822805 0.00388544536937255 NA NA NA hsa-miR-374a-3p NFAT5 0.465360399099794 0.305267458251279 -0.873812260090285 0.0142802458392285 mirMAP -0.129458904757358 0.00396424743551628 NA NA NA hsa-miR-16-2-3p NFATC2 3.79845098071094 1.49120139344659e-13 -0.286059700331541 0.82399568318191 mirMAP -0.505831882428398 0.000198875188682268 NA NA NA hsa-miR-182-5p NFATC2 5.86988712704738 1.22411588571584e-15 -0.286059700331541 0.82399568318191 mirMAP -0.32144165425718 0.000646026696926626 NA NA NA hsa-miR-19b-3p NFATC2 1.67581705793313 0.000858910586302716 -0.286059700331541 0.82399568318191 mirMAP -0.404387130112085 0.00521651290699105 NA NA NA hsa-miR-221-3p NFATC2 0.94082283577318 0.174749164179978 -0.286059700331541 0.82399568318191 MirTarget -0.377449174577961 0.000312614420924495 NA NA NA hsa-miR-222-3p NFATC2 1.54730827524553 0.0223014220569407 -0.286059700331541 0.82399568318191 MirTarget -0.397758818078019 0.000197967348333277 NA NA NA hsa-miR-2355-5p NFATC2 0.418226038913005 0.502149040287915 -0.286059700331541 0.82399568318191 MirTarget -0.399238734977261 0.000639415285590298 NA NA NA hsa-miR-24-3p NFATC2 1.55853749533999 0.000524726461381821 -0.286059700331541 0.82399568318191 MirTarget -0.468867821397621 0.00386071331628823 NA NA NA hsa-miR-26b-3p NFATC2 0.985177548213122 0.0351427970185971 -0.286059700331541 0.82399568318191 MirTarget -0.424161999476118 0.00685427841775268 NA NA NA hsa-miR-27b-5p NFATC2 0.213392605793392 0.71562473353293 -0.286059700331541 0.82399568318191 mirMAP -0.562887952208124 5.3203758057189e-06 NA NA NA hsa-miR-30b-5p NFATC2 0.0238659735605804 0.953223658270319 -0.286059700331541 0.82399568318191 MirTarget;mirMAP -0.701664889521975 0.000103150761633541 NA NA NA hsa-miR-335-3p NFATC2 1.19503568251824 0.0938852560631551 -0.286059700331541 0.82399568318191 mirMAP -0.275457201424799 0.00698833780307122 NA NA NA hsa-miR-33a-3p NFATC2 2.06269680799532 0.00156436055383943 -0.286059700331541 0.82399568318191 mirMAP -0.49218710815049 8.56348757093332e-06 NA NA NA hsa-miR-3607-3p NFATC2 1.38015131722213 0.0240067155694847 -0.286059700331541 0.82399568318191 MirTarget;mirMAP -0.391336207534776 0.000990733127382603 NA NA NA hsa-miR-590-3p NFATC2 2.35429565068338 2.79601879608564e-06 -0.286059700331541 0.82399568318191 mirMAP -0.384051398639096 0.00750996376662493 NA NA NA hsa-miR-9-5p NFATC2 1.79620806707734 0.14526963042518 -0.286059700331541 0.82399568318191 MirTarget -0.179640503569894 0.00223258011764884 NA NA NA hsa-miR-29a-3p NFATC3 -0.638239697975974 0.251923581881716 0.477055216934867 0.106796631983734 MirTarget;miRNATAP -0.140468120986745 2.25586419429949e-06 NA NA NA hsa-miR-30a-5p NFATC3 -0.768430903969183 0.320487552854215 0.477055216934867 0.106796631983734 MirTarget;miRNATAP -0.10800426830215 3.64017456454683e-07 NA NA NA hsa-miR-505-3p NFATC3 0.58881333170866 0.226937454637888 0.477055216934867 0.106796631983734 mirMAP -0.101422391581702 0.00323042227101925 NA NA NA hsa-miR-15b-3p NFATC4 3.57530146629867 5.89922785773482e-11 -3.51227827619475 3.3529829198664e-05 mirMAP -0.332671458598109 0.000109614721294728 NA NA NA hsa-miR-193a-3p NFATC4 0.646392169474854 0.207134343676122 -3.51227827619475 3.3529829198664e-05 miRanda -0.331963642605815 0.000483436127300785 NA NA NA hsa-miR-2355-5p NFATC4 0.418226038913005 0.502149040287915 -3.51227827619475 3.3529829198664e-05 MirTarget -0.222270601628068 0.00449762571989068 NA NA NA hsa-miR-29b-3p NFATC4 0.666547117072858 0.234055379278093 -3.51227827619475 3.3529829198664e-05 miRNATAP -0.269565814376398 0.0019545991736415 NA NA NA hsa-miR-484 NFATC4 1.79050445056016 0.000217287101253701 -3.51227827619475 3.3529829198664e-05 MirTarget;miRNATAP -0.333356851887072 0.000848337680097208 NA NA NA hsa-miR-629-3p NFATC4 3.48282157979573 4.9176538695908e-08 -3.51227827619475 3.3529829198664e-05 mirMAP -0.452159715701377 5.06669620050464e-10 NA NA NA hsa-let-7a-5p NKD1 0.148081801547773 0.645305441523746 -1.98089063442873 0.0698165327979292 TargetScan -0.5394886488876 0.0064772239484111 NA NA NA hsa-miR-200b-3p NKD1 5.56167217794639 6.43540045061709e-16 -1.98089063442873 0.0698165327979292 TargetScan -0.246261562772618 0.00407083131720379 NA NA NA hsa-miR-330-5p NKD1 2.25110496739954 0.000275527655397415 -1.98089063442873 0.0698165327979292 miRanda;miRNATAP -0.323051116539652 0.00114414069657017 NA NA NA hsa-miR-944 NKD1 7.20925181386398 0.000823207457340648 -1.98089063442873 0.0698165327979292 PITA;miRNATAP -0.104617511964737 0.00313578391544455 NA NA NA hsa-let-7b-5p NLK -0.189422992330471 0.651878220048983 0.183543839079865 0.498710830211101 miRNATAP -0.114257517524189 0.00186376055418449 NA NA NA hsa-let-7i-5p NLK 0.0473185312396307 0.869714142234765 0.183543839079865 0.498710830211101 miRNATAP -0.166463992572848 0.00230814976045761 NA NA NA hsa-miR-152-3p NLK 0.0996927696128376 0.867443498706607 0.183543839079865 0.498710830211101 MirTarget -0.100005908022808 8.57051397147721e-05 NA NA NA hsa-miR-221-3p NLK 0.94082283577318 0.174749164179978 0.183543839079865 0.498710830211101 MirTarget;miRNATAP -0.15407716283403 3.74272091558852e-13 NA NA NA hsa-miR-222-3p NLK 1.54730827524553 0.0223014220569407 0.183543839079865 0.498710830211101 MirTarget;miRNATAP -0.141074145632073 1.08276456992864e-10 NA NA NA hsa-miR-222-5p NLK 2.52056758362407 0.00142010793166944 0.183543839079865 0.498710830211101 MirTarget -0.122397786918054 5.03934994367364e-11 NA NA NA hsa-miR-23a-3p NLK 0.925125296618358 0.0127293543936914 0.183543839079865 0.498710830211101 miRNAWalker2_validate;MirTarget -0.111655445486474 0.00729490375203523 NA NA NA hsa-miR-27a-3p NLK 1.76094007417453 0.000216137556256765 0.183543839079865 0.498710830211101 miRNATAP -0.114442011738111 0.000322691345608444 NA NA NA hsa-miR-27b-3p NLK -0.0929089601968123 0.85847352206581 0.183543839079865 0.498710830211101 miRNATAP -0.105967873572703 0.000302277506931224 NA NA NA hsa-miR-342-3p NLK 1.31107714473009 0.0207211910724662 0.183543839079865 0.498710830211101 miRanda -0.124078682939925 3.10194434150662e-06 NA NA NA hsa-miR-142-3p PLCB1 4.35304505457969 3.10014573651358e-10 -1.81436884275205 0.0723908178314423 PITA;miRanda;miRNATAP -0.212315328629979 0.00837775415657827 NA NA NA hsa-miR-16-2-3p PLCB1 3.79845098071094 1.49120139344659e-13 -1.81436884275205 0.0723908178314423 mirMAP -0.319591138268826 0.00293151934803552 NA NA NA hsa-miR-19b-3p PLCB1 1.67581705793313 0.000858910586302716 -1.81436884275205 0.0723908178314423 miRNATAP -0.295421515419568 0.00957725380883961 NA NA NA hsa-miR-205-5p PLCB1 8.08298115900323 3.83045179398654e-07 -1.81436884275205 0.0723908178314423 miRNATAP -0.179652575957285 2.1239580128762e-07 NA NA NA hsa-miR-20a-5p PLCB1 2.13553469875764 0.000181201072324354 -1.81436884275205 0.0723908178314423 miRNATAP -0.26240485806214 0.00867556441357238 NA NA NA hsa-miR-590-3p PLCB1 2.35429565068338 2.79601879608564e-06 -1.81436884275205 0.0723908178314423 PITA;miRanda;mirMAP -0.294674248424645 0.00916966691382528 NA NA NA hsa-miR-9-5p PLCB1 1.79620806707734 0.14526963042518 -1.81436884275205 0.0723908178314423 mirMAP -0.176761177372917 0.000123296624676458 NA NA NA hsa-miR-944 PLCB1 7.20925181386398 0.000823207457340648 -1.81436884275205 0.0723908178314423 PITA;mirMAP -0.167328508617809 2.12356997210001e-07 NA NA NA hsa-miR-125a-5p PLCB3 -1.32352790615388 0.00714301627309467 0.800148438430191 0.0112406480827997 miRanda -0.147616652879399 4.39424570802659e-05 NA NA NA hsa-let-7b-3p PLCB4 0.589364128513318 0.200507534602851 -3.38039309710074 0.0401436033746677 mirMAP;miRNATAP -0.657857764169289 0.00132070975922559 NA NA NA hsa-let-7f-1-3p PLCB4 1.61507869803314 0.00069342464777815 -3.38039309710074 0.0401436033746677 mirMAP -0.884179425801791 6.21055620952821e-06 NA NA NA hsa-miR-16-2-3p PLCB4 3.79845098071094 1.49120139344659e-13 -3.38039309710074 0.0401436033746677 mirMAP -0.582623974128612 0.000878230710514813 NA NA NA hsa-miR-23a-3p PLCB4 0.925125296618358 0.0127293543936914 -3.38039309710074 0.0401436033746677 miRNATAP -1.56589918570536 3.30417922796892e-10 NA NA NA hsa-miR-9-5p PLCB4 1.79620806707734 0.14526963042518 -3.38039309710074 0.0401436033746677 miRNAWalker2_validate;mirMAP -0.223672340449135 0.00306945439314662 NA NA NA hsa-miR-944 PLCB4 7.20925181386398 0.000823207457340648 -3.38039309710074 0.0401436033746677 mirMAP -0.501409266104758 5.5378576748897e-24 NA NA NA hsa-miR-194-3p PPARD 1.91743783341496 0.105383373371284 0.419455821740777 0.283177127294337 MirTarget -0.104075771818383 1.47684555551408e-08 NA NA NA hsa-miR-28-5p PPARD -0.815636722979196 0.0221199948901761 0.419455821740777 0.283177127294337 mirMAP -0.192602555264515 0.00218745384817617 NA NA NA hsa-miR-497-5p PPARD -1.44150596209372 0.0225146607606395 0.419455821740777 0.283177127294337 mirMAP -0.104197870658577 0.00280618926025624 NA NA NA hsa-miR-425-5p PPP2CB 3.15197291080781 3.16652350906107e-07 -1.25447828974493 1.05312923428955e-05 miRNAWalker2_validate -0.110681790089799 1.64448494638146e-05 NA NA NA hsa-miR-590-3p PPP2CB 2.35429565068338 2.79601879608564e-06 -1.25447828974493 1.05312923428955e-05 miRanda -0.128757858804767 5.16847568396067e-05 NA NA NA hsa-miR-125a-5p PPP2R1B -1.32352790615388 0.00714301627309467 0.535943295428266 0.162251997298493 PITA;miRanda -0.114930033410317 0.00930190483964423 NA NA NA hsa-miR-452-5p PPP2R1B 2.45466810475361 0.00114794259949532 0.535943295428266 0.162251997298493 MirTarget -0.106017919286185 0.000183245518742969 NA NA NA hsa-miR-107 PPP2R5A 1.49443409571439 0.000130594521065411 -0.140489073340774 0.671690982688938 miRanda -0.144398642769006 0.00260012205894746 NA NA NA hsa-miR-186-5p PPP2R5C 0.445443449112564 0.185447310527704 -0.316038762242836 0.26720752514426 mirMAP;miRNATAP -0.180523874486163 0.000196249408190972 NA NA NA hsa-miR-101-5p PPP2R5E -1.41522721523565 0.0166784131265028 0.535525914733393 0.120928926594593 MirTarget -0.180690176030252 2.46208790792195e-08 NA NA NA hsa-miR-125a-5p PPP2R5E -1.32352790615388 0.00714301627309467 0.535525914733393 0.120928926594593 miRNAWalker2_validate -0.179165818069827 5.17839779064056e-06 NA NA NA hsa-miR-181c-5p PPP2R5E -0.302833440762172 0.537532549455539 0.535525914733393 0.120928926594593 MirTarget;mirMAP -0.16820871881031 2.25744067324159e-05 NA NA NA hsa-miR-195-3p PPP2R5E -2.39100534119332 0.000185405399054065 0.535525914733393 0.120928926594593 mirMAP -0.121161783375062 6.09529627319605e-05 NA NA NA hsa-miR-29b-2-5p PPP2R5E -0.596051745078872 0.189540844841389 0.535525914733393 0.120928926594593 mirMAP -0.240263449414642 1.5497933709251e-08 NA NA NA hsa-miR-30a-5p PPP2R5E -0.768430903969183 0.320487552854215 0.535525914733393 0.120928926594593 mirMAP -0.111068835600136 8.55978751796861e-06 NA NA NA hsa-miR-30b-5p PPP2R5E 0.0238659735605804 0.953223658270319 0.535525914733393 0.120928926594593 mirMAP -0.149474692025846 0.00208479541033403 NA NA NA hsa-miR-30d-3p PPP2R5E -0.0740421896025512 0.857423650167556 0.535525914733393 0.120928926594593 MirTarget -0.144308649360449 0.00260698547448653 NA NA NA hsa-miR-30e-3p PPP2R5E -0.0362193022195196 0.932577027239525 0.535525914733393 0.120928926594593 MirTarget -0.119486384973344 0.00965259842012976 NA NA NA hsa-miR-30e-5p PPP2R5E 0.780047227271616 0.0346714425913016 0.535525914733393 0.120928926594593 mirMAP -0.190433556521116 0.000361265009878909 NA NA NA hsa-miR-3607-3p PPP2R5E 1.38015131722213 0.0240067155694847 0.535525914733393 0.120928926594593 mirMAP;miRNATAP -0.102503532433218 0.00126886534770206 NA NA NA hsa-miR-374b-5p PPP2R5E -0.114749866169918 0.764888930049438 0.535525914733393 0.120928926594593 mirMAP -0.141522657991467 0.00619666437031856 NA NA NA hsa-let-7g-5p PPP3CA 0.857251702023746 0.00647597344297273 -0.0994691469518081 0.767527156115313 miRNATAP -0.161347150543761 0.00879795113322894 NA NA NA hsa-miR-141-3p PRICKLE1 7.30474126597325 1.45115996357606e-24 -3.02552871002129 0.00131232153959817 TargetScan -0.398898827959149 4.4175751955465e-09 NA NA NA hsa-miR-17-5p PRICKLE1 2.3269271449522 2.13987445663942e-05 -3.02552871002129 0.00131232153959817 miRNAWalker2_validate -0.271468501852006 0.00529473692424031 NA NA NA hsa-miR-192-5p PRICKLE1 1.77716187978541 0.113485496183047 -3.02552871002129 0.00131232153959817 miRNAWalker2_validate -0.257468457622056 3.84362272784163e-08 NA NA NA hsa-miR-215-5p PRICKLE1 3.66990923176752 0.00294614570694381 -3.02552871002129 0.00131232153959817 miRNAWalker2_validate -0.255545939161005 1.42291724246968e-09 NA NA NA hsa-miR-3065-5p PRICKLE1 2.14185373842821 0.0609400502269891 -3.02552871002129 0.00131232153959817 mirMAP -0.152694399920415 0.00903665256532244 NA NA NA hsa-miR-30b-5p PRICKLE1 0.0238659735605804 0.953223658270319 -3.02552871002129 0.00131232153959817 mirMAP -0.376398378671489 0.00500957386454352 NA NA NA hsa-miR-338-3p PRICKLE1 0.447551118940466 0.558485097370031 -3.02552871002129 0.00131232153959817 miRanda -0.220142690785802 0.0017159550637653 NA NA NA hsa-miR-582-5p PRICKLE1 0.685177900016753 0.447761540297692 -3.02552871002129 0.00131232153959817 miRNATAP -0.232483699486703 8.43679696263967e-05 NA NA NA hsa-let-7b-3p PRICKLE2 0.589364128513318 0.200507534602851 -3.45141746786942 2.23819194762863e-06 mirMAP -0.246312978579838 0.00756229568470298 NA NA NA hsa-let-7f-1-3p PRICKLE2 1.61507869803314 0.00069342464777815 -3.45141746786942 2.23819194762863e-06 mirMAP -0.308078106997812 0.000495101004435929 NA NA NA hsa-miR-146a-5p PRICKLE2 2.64646698525354 0.000280611928973036 -3.45141746786942 2.23819194762863e-06 mirMAP -0.160745001027756 0.00493178107285413 NA NA NA hsa-miR-148b-3p PRICKLE2 1.75622244535669 8.84414356040579e-08 -3.45141746786942 2.23819194762863e-06 MirTarget;miRNATAP -0.428977213345021 0.000796450369894216 NA NA NA hsa-miR-150-5p PRICKLE2 1.76769157530064 0.0593795975117846 -3.45141746786942 2.23819194762863e-06 MirTarget -0.130596972874792 0.00344135932488411 NA NA NA hsa-miR-15b-3p PRICKLE2 3.57530146629867 5.89922785773482e-11 -3.45141746786942 2.23819194762863e-06 mirMAP -0.305418579191281 3.91799008722286e-05 NA NA NA hsa-miR-16-2-3p PRICKLE2 3.79845098071094 1.49120139344659e-13 -3.45141746786942 2.23819194762863e-06 mirMAP -0.394528740870726 3.82910940604498e-07 NA NA NA hsa-miR-18a-5p PRICKLE2 3.90770175770219 9.15298615034137e-10 -3.45141746786942 2.23819194762863e-06 MirTarget -0.186919696461069 0.00354397953056611 NA NA NA hsa-miR-203a-3p PRICKLE2 6.35084246337388 7.89944323347948e-08 -3.45141746786942 2.23819194762863e-06 MirTarget -0.143413825673005 3.04290466636865e-05 NA NA NA hsa-miR-21-5p PRICKLE2 2.65163477806992 6.72089787690756e-16 -3.45141746786942 2.23819194762863e-06 miRNAWalker2_validate;MirTarget -0.411551709864877 0.000912823366410808 NA NA NA hsa-miR-221-5p PRICKLE2 2.07459535854377 0.0757339015356929 -3.45141746786942 2.23819194762863e-06 MirTarget -0.112767891096494 0.00182590919526375 NA NA NA hsa-miR-330-3p PRICKLE2 2.49094236945806 0.000129367003214715 -3.45141746786942 2.23819194762863e-06 MirTarget -0.242408684206499 0.000148397852684028 NA NA NA hsa-miR-330-5p PRICKLE2 2.25110496739954 0.000275527655397415 -3.45141746786942 2.23819194762863e-06 miRanda;miRNATAP -0.304068403465464 5.24453460154095e-06 NA NA NA hsa-miR-33a-3p PRICKLE2 2.06269680799532 0.00156436055383943 -3.45141746786942 2.23819194762863e-06 mirMAP -0.169610144531884 0.00853422264620373 NA NA NA hsa-miR-33a-5p PRICKLE2 2.60046838991599 0.000472459723448608 -3.45141746786942 2.23819194762863e-06 MirTarget -0.208858942311621 0.000179412583116712 NA NA NA hsa-miR-33b-5p PRICKLE2 4.77891217497671 1.33695107675057e-08 -3.45141746786942 2.23819194762863e-06 MirTarget -0.308295499263836 9.41436315322474e-11 NA NA NA hsa-miR-429 PRICKLE2 6.39965293994036 1.96920201593608e-18 -3.45141746786942 2.23819194762863e-06 miRNATAP -0.192564785179246 0.000363170475329292 NA NA NA hsa-miR-484 PRICKLE2 1.79050445056016 0.000217287101253701 -3.45141746786942 2.23819194762863e-06 miRNATAP -0.261502761906927 0.00251914112807643 NA NA NA hsa-miR-590-3p PRICKLE2 2.35429565068338 2.79601879608564e-06 -3.45141746786942 2.23819194762863e-06 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.280024083689801 0.00069950432111314 NA NA NA hsa-miR-592 PRICKLE2 2.80403350008555 0.0293520213681333 -3.45141746786942 2.23819194762863e-06 mirMAP -0.124045316601949 0.00188888312343625 NA NA NA hsa-miR-629-3p PRICKLE2 3.48282157979573 4.9176538695908e-08 -3.45141746786942 2.23819194762863e-06 MirTarget -0.289397005386756 5.78872525645679e-06 NA NA NA hsa-miR-7-1-3p PRICKLE2 1.43074343339835 0.00471215970502094 -3.45141746786942 2.23819194762863e-06 MirTarget -0.317376129149821 0.000124131315390086 NA NA NA hsa-let-7a-3p PRKACB 0.82512001802525 0.0468122405194487 -1.46896806095161 0.00691161548744777 MirTarget;mirMAP;miRNATAP -0.212227756129949 0.00484060334729975 NA NA NA hsa-miR-141-3p PRKACB 7.30474126597325 1.45115996357606e-24 -1.46896806095161 0.00691161548744777 MirTarget;TargetScan;miRNATAP -0.179713976485568 5.50509722074074e-06 NA NA NA hsa-miR-16-2-3p PRKACB 3.79845098071094 1.49120139344659e-13 -1.46896806095161 0.00691161548744777 mirMAP -0.256987391063205 7.64721558586313e-06 NA NA NA hsa-miR-17-5p PRKACB 2.3269271449522 2.13987445663942e-05 -1.46896806095161 0.00691161548744777 TargetScan -0.147030961972885 0.00870649595844882 NA NA NA hsa-miR-182-5p PRKACB 5.86988712704738 1.22411588571584e-15 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.137741652786639 0.000572629355125557 NA NA NA hsa-miR-183-5p PRKACB 6.61903249270777 1.00958881445636e-16 -1.46896806095161 0.00691161548744777 MirTarget -0.125680903296988 0.000602029705127091 NA NA NA hsa-miR-18a-5p PRKACB 3.90770175770219 9.15298615034137e-10 -1.46896806095161 0.00691161548744777 miRNATAP -0.147626596716624 0.00172397395444837 NA NA NA hsa-miR-193a-3p PRKACB 0.646392169474854 0.207134343676122 -1.46896806095161 0.00691161548744777 miRanda -0.257394862253127 1.9252355211219e-05 NA NA NA hsa-miR-19a-3p PRKACB 2.17020503944519 0.00122084653711062 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.131490327577289 0.0040920531186784 NA NA NA hsa-miR-19b-3p PRKACB 1.67581705793313 0.000858910586302716 -1.46896806095161 0.00691161548744777 miRNAWalker2_validate;MirTarget;miRNATAP -0.191193316637283 0.00183404785527112 NA NA NA hsa-miR-200a-3p PRKACB 6.336081120041 4.024313571871e-16 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.104144124001908 0.00576356163422443 NA NA NA hsa-miR-200c-3p PRKACB 6.47012025883743 2.64500707716408e-26 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.145130591541329 0.00181365494045828 NA NA NA hsa-miR-3065-5p PRKACB 2.14185373842821 0.0609400502269891 -1.46896806095161 0.00691161548744777 MirTarget -0.128827162641901 0.000116356569225078 NA NA NA hsa-miR-429 PRKACB 6.39965293994036 1.96920201593608e-18 -1.46896806095161 0.00691161548744777 MirTarget;PITA;miRanda;miRNATAP -0.108770954611392 0.00641118010678973 NA NA NA hsa-miR-93-5p PRKACB 2.65964181833033 2.58315947526774e-08 -1.46896806095161 0.00691161548744777 miRNAWalker2_validate -0.1828758599464 0.00409856289818273 NA NA NA hsa-miR-96-5p PRKACB 5.62521466029286 1.54938806718028e-10 -1.46896806095161 0.00691161548744777 miRNATAP -0.17033105097326 3.99524226143001e-05 NA NA NA hsa-miR-142-5p PRKCA 3.95552531913424 1.49536283724079e-08 -2.51484065178579 0.000301846026330391 mirMAP -0.157985182568495 0.00450284307697346 NA NA NA hsa-miR-183-5p PRKCA 6.61903249270777 1.00958881445636e-16 -2.51484065178579 0.000301846026330391 miRNATAP -0.195964689338451 2.96312561009603e-05 NA NA NA hsa-miR-200c-3p PRKCA 6.47012025883743 2.64500707716408e-26 -2.51484065178579 0.000301846026330391 miRNATAP -0.227644911192639 0.000134967313056447 NA NA NA hsa-miR-30e-3p PRKCA -0.0362193022195196 0.932577027239525 -2.51484065178579 0.000301846026330391 mirMAP -0.330264937460595 0.000431865199778726 NA NA NA hsa-miR-330-3p PRKCA 2.49094236945806 0.000129367003214715 -2.51484065178579 0.000301846026330391 mirMAP -0.173880498227238 0.0042321147753766 NA NA NA hsa-miR-340-5p PRKCA 1.41210478721579 0.00958612942879818 -2.51484065178579 0.000301846026330391 mirMAP -0.247780249808726 0.000683356782218492 NA NA NA hsa-miR-374a-3p PRKCA 0.465360399099794 0.305267458251279 -2.51484065178579 0.000301846026330391 mirMAP -0.324087022951615 0.000236966482552477 NA NA NA hsa-miR-374a-5p PRKCA 0.278549982012055 0.45888283715888 -2.51484065178579 0.000301846026330391 mirMAP -0.315860192203564 0.00334938709870334 NA NA NA hsa-miR-590-3p PRKCA 2.35429565068338 2.79601879608564e-06 -2.51484065178579 0.000301846026330391 PITA;miRanda;mirMAP;miRNATAP -0.344157378397527 9.41463074505618e-06 NA NA NA hsa-miR-9-5p PRKCA 1.79620806707734 0.14526963042518 -2.51484065178579 0.000301846026330391 miRNATAP -0.102263861653536 0.00143068318206041 NA NA NA hsa-miR-944 PRKCA 7.20925181386398 0.000823207457340648 -2.51484065178579 0.000301846026330391 PITA;miRNATAP -0.163061119524878 9.18211721568101e-14 NA NA NA hsa-miR-129-5p PRKCB -2.66843722411409 0.00695783358331245 -1.37779465994896 0.125783325051528 miRanda;mirMAP -0.148528580809065 0.00435751368999719 NA NA NA hsa-miR-130a-5p PRKCB 1.58028512890005 0.024346333013728 -1.37779465994896 0.125783325051528 mirMAP -0.212100504604163 0.00409650973476373 NA NA NA hsa-miR-141-5p PRKCB 7.13744624551943 4.06877058732583e-26 -1.37779465994896 0.125783325051528 mirMAP -0.19239678572128 0.00558256661173632 NA NA NA hsa-miR-200b-3p PRKCB 5.56167217794639 6.43540045061709e-16 -1.37779465994896 0.125783325051528 MirTarget -0.301150868895001 1.67192981795653e-05 NA NA NA hsa-miR-200c-3p PRKCB 6.47012025883743 2.64500707716408e-26 -1.37779465994896 0.125783325051528 MirTarget;miRNATAP -0.348745791831867 4.59454351785762e-06 NA NA NA hsa-miR-24-3p PRKCB 1.55853749533999 0.000524726461381821 -1.37779465994896 0.125783325051528 miRNATAP -0.348466036252195 0.00216084517312112 NA NA NA hsa-miR-30d-3p PRKCB -0.0740421896025512 0.857423650167556 -1.37779465994896 0.125783325051528 mirMAP -0.466704414757516 0.000189785701017437 NA NA NA hsa-miR-335-3p PRKCB 1.19503568251824 0.0938852560631551 -1.37779465994896 0.125783325051528 mirMAP -0.319943845988664 6.21148850866805e-06 NA NA NA hsa-miR-335-5p PRKCB 0.167216045757305 0.803897055331049 -1.37779465994896 0.125783325051528 mirMAP -0.264751633170281 0.000471558920124749 NA NA NA hsa-miR-429 PRKCB 6.39965293994036 1.96920201593608e-18 -1.37779465994896 0.125783325051528 MirTarget;miRanda;miRNATAP -0.361917851736747 2.11441310702277e-08 NA NA NA hsa-miR-589-3p PRKCB 1.33205316880069 0.052632683806148 -1.37779465994896 0.125783325051528 mirMAP -0.256370688506043 0.000574321239976677 NA NA NA hsa-miR-590-5p PRKCB 1.51400888103768 0.0023888567923017 -1.37779465994896 0.125783325051528 miRanda -0.299520538968311 0.00345339662465929 NA NA NA hsa-miR-9-3p PRKCB 1.69328215716742 0.125170982657059 -1.37779465994896 0.125783325051528 mirMAP -0.175906285304137 0.000158783736278398 NA NA NA hsa-miR-130a-5p PRKX 1.58028512890005 0.024346333013728 2.17507999383594 0.000704686070863552 mirMAP -0.187730727746443 0.00038419514315305 NA NA NA hsa-miR-148b-3p PRKX 1.75622244535669 8.84414356040579e-08 2.17507999383594 0.000704686070863552 MirTarget -0.306982570800927 0.00606517379097925 NA NA NA hsa-miR-335-3p PRKX 1.19503568251824 0.0938852560631551 2.17507999383594 0.000704686070863552 mirMAP -0.162862473837577 0.00148982890472507 NA NA NA hsa-miR-186-5p PSEN1 0.445443449112564 0.185447310527704 0.368661147327623 0.170605556176267 mirMAP -0.185745049339955 4.75468410670268e-05 NA NA NA hsa-miR-374a-5p RAC1 0.278549982012055 0.45888283715888 0.0440982372971011 0.900045954349393 mirMAP -0.140356402054542 0.00882655342567711 NA NA NA hsa-miR-450b-5p RAC1 0.445103105471153 0.416021465008949 0.0440982372971011 0.900045954349393 mirMAP -0.108599310907085 0.00278942668689792 NA NA NA hsa-miR-129-5p RAC2 -2.66843722411409 0.00695783358331245 1.63571810371488 0.0215946836435966 miRanda -0.123304880787715 0.00280670600839041 NA NA NA hsa-let-7a-3p ROCK2 0.82512001802525 0.0468122405194487 -0.982794429557542 0.144534846884159 mirMAP -0.287135080994927 0.00198598698276818 NA NA NA hsa-miR-142-3p ROCK2 4.35304505457969 3.10014573651358e-10 -0.982794429557542 0.144534846884159 PITA;miRanda;miRNATAP -0.159877164823284 0.00282210588614417 NA NA NA hsa-miR-224-3p ROCK2 2.84876340814503 0.000179138399939161 -0.982794429557542 0.144534846884159 mirMAP -0.138248944552857 0.00579163824403207 NA NA NA hsa-miR-3607-3p ROCK2 1.38015131722213 0.0240067155694847 -0.982794429557542 0.144534846884159 mirMAP -0.228150377670738 0.000240782728860781 NA NA NA hsa-miR-590-3p ROCK2 2.35429565068338 2.79601879608564e-06 -0.982794429557542 0.144534846884159 miRanda;mirMAP -0.284800877986152 0.000141234831462107 NA NA NA hsa-miR-16-1-3p SFRP1 2.83281226969693 7.54359864580834e-09 -4.05099494825295 0.00788885256174047 MirTarget -0.549041537326192 0.00156963680356568 NA NA NA hsa-miR-182-5p SFRP1 5.86988712704738 1.22411588571584e-15 -4.05099494825295 0.00788885256174047 mirMAP -0.37114475228972 0.000961641414082013 NA NA NA hsa-miR-19b-1-5p SFRP1 1.51335451095424 0.0014717605268143 -4.05099494825295 0.00788885256174047 MirTarget -0.505630617444352 0.00568002812072431 NA NA NA hsa-miR-203a-3p SFRP1 6.35084246337388 7.89944323347948e-08 -4.05099494825295 0.00788885256174047 MirTarget -0.346403144409134 9.53807015666787e-07 NA NA NA hsa-miR-33a-3p SFRP1 2.06269680799532 0.00156436055383943 -4.05099494825295 0.00788885256174047 MirTarget -0.687662787724045 1.5419508092046e-07 NA NA NA hsa-miR-429 SFRP1 6.39965293994036 1.96920201593608e-18 -4.05099494825295 0.00788885256174047 miRNATAP -0.634291762958993 7.50057649683851e-09 NA NA NA hsa-miR-501-5p SFRP1 1.0411896821345 0.0777206709183552 -4.05099494825295 0.00788885256174047 mirMAP -0.396225021182035 0.00725128386303335 NA NA NA hsa-miR-940 SFRP1 3.78496690968119 4.75227557809023e-05 -4.05099494825295 0.00788885256174047 MirTarget -0.304584104323152 0.00701763875280759 NA NA NA hsa-miR-96-5p SFRP1 5.62521466029286 1.54938806718028e-10 -4.05099494825295 0.00788885256174047 mirMAP -0.392815384619956 0.000786676354596085 NA NA NA hsa-miR-582-5p SFRP2 0.685177900016753 0.447761540297692 1.32453723410308 0.331501794222753 miRNATAP -0.242546911407179 0.00458427423019383 NA NA NA hsa-miR-144-5p SFRP4 1.01673279814999 0.403344913421629 -5.17574172449817 0.00555408538544092 MirTarget -0.359839289193151 3.20171457086971e-05 NA NA NA hsa-let-7g-3p SMAD3 2.09736290930341 5.30067796437833e-05 0.160014583572917 0.778517282766047 mirMAP -0.257984897034794 2.44423650375142e-05 NA NA NA hsa-miR-17-5p SMAD3 2.3269271449522 2.13987445663942e-05 0.160014583572917 0.778517282766047 miRNAWalker2_validate -0.165009353618131 0.00461261808419179 NA NA NA hsa-miR-186-5p SMAD3 0.445443449112564 0.185447310527704 0.160014583572917 0.778517282766047 mirMAP -0.742764319550064 2.12349457043014e-15 NA NA NA hsa-miR-188-5p SMAD3 1.39111178824125 0.0251592818948912 0.160014583572917 0.778517282766047 PITA -0.238758119317103 3.46346507109757e-06 NA NA NA hsa-miR-28-5p SMAD3 -0.815636722979196 0.0221199948901761 0.160014583572917 0.778517282766047 miRNATAP -0.238288702750939 0.00948140473131226 NA NA NA hsa-miR-29b-2-5p SMAD3 -0.596051745078872 0.189540844841389 0.160014583572917 0.778517282766047 mirMAP -0.33018047859631 3.00181288669247e-06 NA NA NA hsa-miR-30a-3p SMAD3 -1.22212086897848 0.167565797592104 0.160014583572917 0.778517282766047 mirMAP -0.125743455849957 0.000500972339732145 NA NA NA hsa-miR-30d-3p SMAD3 -0.0740421896025512 0.857423650167556 0.160014583572917 0.778517282766047 mirMAP -0.265215856067837 0.000784444342632096 NA NA NA hsa-miR-32-3p SMAD3 2.20477794939766 0.0392771274032852 0.160014583572917 0.778517282766047 mirMAP -0.139443193805526 0.00854369021916498 NA NA NA hsa-miR-335-3p SMAD3 1.19503568251824 0.0938852560631551 0.160014583572917 0.778517282766047 mirMAP -0.150203529209219 0.000833797912476475 NA NA NA hsa-miR-335-5p SMAD3 0.167216045757305 0.803897055331049 0.160014583572917 0.778517282766047 miRNAWalker2_validate -0.170051000133026 0.000363968836124472 NA NA NA hsa-miR-345-5p SMAD3 2.77314563304336 4.34343702412489e-05 0.160014583572917 0.778517282766047 mirMAP -0.193422457386819 3.24971867546412e-05 NA NA NA hsa-miR-501-5p SMAD3 1.0411896821345 0.0777206709183552 0.160014583572917 0.778517282766047 mirMAP -0.280514332977103 1.82290826802372e-07 NA NA NA hsa-miR-589-3p SMAD3 1.33205316880069 0.052632683806148 0.160014583572917 0.778517282766047 mirMAP -0.202014876353946 1.49389042617214e-05 NA NA NA hsa-miR-616-5p SMAD3 2.48416313933027 0.00318247475868827 0.160014583572917 0.778517282766047 mirMAP -0.241397292057418 2.69938790277874e-07 NA NA NA hsa-miR-671-5p SMAD3 1.48527046124636 0.00686722328347111 0.160014583572917 0.778517282766047 MirTarget -0.193412590030654 0.000928749665735432 NA NA NA hsa-miR-7-1-3p SMAD3 1.43074343339835 0.00471215970502094 0.160014583572917 0.778517282766047 mirMAP -0.168365832898427 0.00819700709319524 NA NA NA hsa-miR-769-5p SMAD3 0.41777775802937 0.343089124193569 0.160014583572917 0.778517282766047 miRNATAP -0.366412732630904 4.82674495052425e-07 NA NA NA hsa-miR-21-3p SMAD4 3.50297439576639 6.39946844099206e-10 -1.1222647897474 0.00638923144286853 mirMAP -0.112729088104479 0.00502861854832022 NA NA NA hsa-miR-27a-3p SMAD4 1.76094007417453 0.000216137556256765 -1.1222647897474 0.00638923144286853 MirTarget -0.132335336531126 0.00695151522053189 NA NA NA hsa-miR-330-5p SOX17 2.25110496739954 0.000275527655397415 -4.63134297267781 0.000312264433803198 miRanda -0.471495211507339 5.74811025406178e-05 NA NA NA hsa-miR-142-3p TBL1X 4.35304505457969 3.10014573651358e-10 -2.18091245523924 4.00427713003879e-05 MirTarget;PITA;miRanda;miRNATAP -0.164381176345582 0.00010822877011412 NA NA NA hsa-miR-484 TBL1X 1.79050445056016 0.000217287101253701 -2.18091245523924 4.00427713003879e-05 PITA -0.231411278192992 0.000209247258351217 NA NA NA hsa-miR-181a-5p TBL1XR1 1.25558293560636 0.00748975499703878 0.860959882206589 0.0161483647891579 mirMAP -0.127758983298776 0.00318260973301241 NA NA NA hsa-miR-181c-5p TBL1XR1 -0.302833440762172 0.537532549455539 0.860959882206589 0.0161483647891579 MirTarget;mirMAP -0.121585763845284 0.00346013270504262 NA NA NA hsa-miR-142-5p TCF7L1 3.95552531913424 1.49536283724079e-08 -2.01358509693913 0.0134449848880761 PITA -0.212267103740507 0.00102071148741226 NA NA NA hsa-miR-200a-3p TCF7L1 6.336081120041 4.024313571871e-16 -2.01358509693913 0.0134449848880761 miRNAWalker2_validate -0.203461925521664 0.000299485175056615 NA NA NA hsa-miR-200b-3p TCF7L1 5.56167217794639 6.43540045061709e-16 -2.01358509693913 0.0134449848880761 miRNAWalker2_validate -0.213878073046112 0.000814272240549089 NA NA NA hsa-miR-155-5p TCF7L2 2.81443182173772 7.42530504828797e-05 -1.23546095022525 0.000440438934902147 MirTarget;miRNATAP -0.104046086417659 0.000174591712156132 NA NA NA hsa-miR-193a-3p TCF7L2 0.646392169474854 0.207134343676122 -1.23546095022525 0.000440438934902147 miRanda -0.157722671038068 5.3142399209646e-05 NA NA NA hsa-miR-942-5p TCF7L2 3.36242661558642 1.89848306955335e-10 -1.23546095022525 0.000440438934902147 MirTarget -0.146878706302034 6.24208059630175e-05 NA NA NA hsa-miR-148a-3p VANGL1 1.1031350648218 0.052038169812979 1.13984796839351 0.000569278893221097 mirMAP -0.126007552197972 0.000135485224544635 NA NA NA hsa-miR-26a-5p VANGL1 -0.352368463397074 0.362040749917446 1.13984796839351 0.000569278893221097 mirMAP -0.163235502722612 0.000936038031106047 NA NA NA hsa-miR-29a-5p VANGL1 0.0748295222568571 0.884125894063293 1.13984796839351 0.000569278893221097 mirMAP -0.100073965894972 0.00672264355888395 NA NA NA hsa-miR-374a-3p VANGL1 0.465360399099794 0.305267458251279 1.13984796839351 0.000569278893221097 mirMAP -0.129036105786491 0.00202204519960015 NA NA NA hsa-miR-590-3p VANGL1 2.35429565068338 2.79601879608564e-06 1.13984796839351 0.000569278893221097 miRanda -0.107912071602501 0.00358015608999926 NA NA NA hsa-miR-186-5p VANGL2 0.445443449112564 0.185447310527704 0.992854229029871 0.242960635033609 mirMAP -0.39410517411477 0.00719264293797182 NA NA NA hsa-miR-30a-5p VANGL2 -0.768430903969183 0.320487552854215 0.992854229029871 0.242960635033609 mirMAP -0.238856634940204 0.000115346457577537 NA NA NA hsa-miR-582-3p VANGL2 0.280903327757368 0.772626550200977 0.992854229029871 0.242960635033609 mirMAP -0.152108361860204 0.00209454847984174 NA NA NA hsa-miR-582-5p VANGL2 0.685177900016753 0.447761540297692 0.992854229029871 0.242960635033609 PITA;miRNATAP -0.175470012023391 0.000973319706525932 NA NA NA hsa-miR-589-3p VANGL2 1.33205316880069 0.052632683806148 0.992854229029871 0.242960635033609 mirMAP -0.203355021483621 0.00391238641397579 NA NA NA hsa-miR-589-5p VANGL2 1.55790780760302 0.000326340665093671 0.992854229029871 0.242960635033609 mirMAP -0.326311110039648 0.00337063244243347 NA NA NA hsa-miR-96-5p VANGL2 5.62521466029286 1.54938806718028e-10 0.992854229029871 0.242960635033609 TargetScan -0.180079366190349 0.00566800729841227 NA NA NA hsa-miR-330-3p WIF1 2.49094236945806 0.000129367003214715 -3.0008918844809 0.103713979441329 PITA;miRNATAP -0.468999434893068 0.00335514436899957 NA NA NA hsa-miR-330-5p WIF1 2.25110496739954 0.000275527655397415 -3.0008918844809 0.103713979441329 miRanda -0.595586503986047 0.000372749451536107 NA NA NA hsa-miR-342-3p WIF1 1.31107714473009 0.0207211910724662 -3.0008918844809 0.103713979441329 miRanda -0.646060279165219 0.000454416850868616 NA NA NA hsa-miR-664a-3p WNT10A 0.249882351950296 0.56171157318348 4.50187444135611 0.000590394273747734 mirMAP -0.487836890480239 0.00563420427073706 NA NA NA hsa-miR-590-3p WNT11 2.35429565068338 2.79601879608564e-06 -1.12002304030541 0.399603501707316 miRanda -0.529097966959972 0.000347687911762461 NA NA NA hsa-miR-146b-3p WNT16 1.34608871980101 0.00935728391852709 0.34788001398837 0.748349917696045 MirTarget -0.37742443073334 0.00145623124068643 NA NA NA hsa-miR-338-3p WNT16 0.447551118940466 0.558485097370031 0.34788001398837 0.748349917696045 miRanda -0.226165128589222 0.00487183921721476 NA NA NA hsa-miR-339-5p WNT16 1.23326828594484 0.0307501214818698 0.34788001398837 0.748349917696045 miRanda -0.331104236072021 0.00208818597534857 NA NA NA hsa-let-7f-2-3p WNT2 1.02768112108475 0.0787293499732611 -3.299390730363 0.00348976107203057 MirTarget -0.299782609265936 0.00806308209760041 NA NA NA hsa-miR-324-5p WNT2 1.31253452379847 0.0116806680545163 -3.299390730363 0.00348976107203057 miRanda -0.36189140777637 0.00350229441341699 NA NA NA hsa-miR-335-3p WNT2 1.19503568251824 0.0938852560631551 -3.299390730363 0.00348976107203057 mirMAP -0.35269768882803 8.41491455046423e-05 NA NA NA hsa-miR-944 WNT2 7.20925181386398 0.000823207457340648 -3.299390730363 0.00348976107203057 mirMAP -0.146635065441429 6.02984984638211e-05 NA NA NA hsa-miR-125a-3p WNT2B -0.0748960586927341 0.920735897434087 -0.856171452484765 0.502995562863325 miRanda -0.504617595226248 1.05618585936844e-07 NA NA NA hsa-miR-186-5p WNT2B 0.445443449112564 0.185447310527704 -0.856171452484765 0.502995562863325 mirMAP -0.83839518234891 0.000129537010945903 NA NA NA hsa-miR-301a-3p WNT2B 1.99338115332667 0.000813358604963724 -0.856171452484765 0.502995562863325 MirTarget -0.342895282405635 0.00462467447879055 NA NA NA hsa-miR-616-5p WNT2B 2.48416313933027 0.00318247475868827 -0.856171452484765 0.502995562863325 mirMAP -0.509721719846027 1.50040236285173e-06 NA NA NA hsa-miR-192-5p WNT3 1.77716187978541 0.113485496183047 3.00467776067193 0.00323304601055451 miRNAWalker2_validate -0.152954353312327 0.00301888019712671 NA NA NA hsa-miR-107 WNT4 1.49443409571439 0.000130594521065411 0.346156151965651 0.759005168873886 PITA;miRNATAP -0.706595074754511 1.43378256348642e-05 NA NA NA hsa-miR-141-3p WNT5A 7.30474126597325 1.45115996357606e-24 -0.335254267155151 0.714960765245992 TargetScan -0.185678372077036 0.00570301174175726 NA NA NA hsa-miR-15b-3p WNT5A 3.57530146629867 5.89922785773482e-11 -0.335254267155151 0.714960765245992 mirMAP -0.24311589972858 0.00863820879774156 NA NA NA hsa-miR-16-2-3p WNT5A 3.79845098071094 1.49120139344659e-13 -0.335254267155151 0.714960765245992 MirTarget;mirMAP -0.311764225567874 0.00135279684345927 NA NA NA hsa-miR-16-5p WNT5A 2.93575808220754 2.15436817162977e-10 -0.335254267155151 0.714960765245992 miRNAWalker2_validate -0.290441753916783 0.00829455186858816 NA NA NA hsa-miR-2110 WNT5A 1.8070969695103 0.00137196847440523 -0.335254267155151 0.714960765245992 MirTarget -0.30255767867938 0.00122728628679992 NA NA NA hsa-miR-30c-5p WNT5A 0.38723991118075 0.348605235643473 -0.335254267155151 0.714960765245992 mirMAP -0.369350346658232 0.00376556464462393 NA NA NA hsa-miR-30d-3p WNT5A -0.0740421896025512 0.857423650167556 -0.335254267155151 0.714960765245992 mirMAP -0.440328526023165 0.000555223243909098 NA NA NA hsa-miR-30d-5p WNT5A 0.302504510257496 0.380193536606962 -0.335254267155151 0.714960765245992 mirMAP -0.416582436731857 0.00691722632235903 NA NA NA hsa-miR-30e-5p WNT5A 0.780047227271616 0.0346714425913016 -0.335254267155151 0.714960765245992 mirMAP -0.392965061384389 0.00598951520393619 NA NA NA hsa-miR-330-5p WNT5A 2.25110496739954 0.000275527655397415 -0.335254267155151 0.714960765245992 miRanda -0.317182601686914 0.00013146381356929 NA NA NA hsa-miR-582-5p WNT5A 0.685177900016753 0.447761540297692 -0.335254267155151 0.714960765245992 miRNATAP -0.175734719122522 0.00222477334080145 NA NA NA hsa-miR-616-5p WNT5A 2.48416313933027 0.00318247475868827 -0.335254267155151 0.714960765245992 mirMAP -0.276707442691596 0.000306684343847227 NA NA NA hsa-miR-92a-3p WNT5A 1.87892405805529 1.27013821556583e-05 -0.335254267155151 0.714960765245992 miRNAWalker2_validate -0.492024474546178 3.85220646721685e-05 NA NA NA hsa-miR-103a-3p WNT7A 0.990919087251708 0.00468308601422847 1.99490211423871 0.283859716193086 MirTarget -1.32781551331516 1.1801181900249e-05 NA NA NA hsa-miR-107 WNT7A 1.49443409571439 0.000130594521065411 1.99490211423871 0.283859716193086 MirTarget;miRanda -0.773176469447409 0.00437990373456198 NA NA NA hsa-miR-15b-5p WNT7A 3.32329949959268 8.40210501034588e-13 1.99490211423871 0.283859716193086 MirTarget -0.65869802593554 0.00275936276249016 27195958 WNT7A Regulation by miR 15b in Ovarian Cancer; In the present study we report that WNT7A is a direct target of miR-15b in ovarian cancer; We showed that a luciferase reporter containing the putative binding site of miR-15b in the WNT7A 3'-UTR was significantly repressed by miR-15b; Mutation of the putative binding site of miR-15b in the WNT7A 3'-UTR restored luciferase activity; Furthermore miR-15b was able to repress increased levels of TOPFLASH activity by WNT7A but not those induced by S33Y; Additionally miR-15b dose-dependently decreased WNT7A expression; When we evaluated the prognostic impact of WNT7A and miR-15b expression using TCGA datasets a significant inverse correlation in which high-expression of WNT7A and low-expression of miR-15b was associated with reduced survival rates of ovarian cancer patients; These results suggest that WNT7A is post-transcriptionally regulated by miR-15b which could be down-regulated by promoter hypermethylation potentially via DNMT1 in ovarian cancer poor survival ovarian cancer hsa-miR-361-5p WNT7A 0.00649167180664723 0.985202350239079 1.99490211423871 0.283859716193086 MirTarget;PITA;miRanda -1.43618972738794 2.43966057288788e-06 NA NA NA hsa-miR-592 WNT7A 2.80403350008555 0.0293520213681333 1.99490211423871 0.283859716193086 mirMAP -0.379438925337118 0.000144596464812367 NA NA NA hsa-miR-10a-5p WNT7B -0.482300926520507 0.594608783320466 6.45833028681074 1.2743062072308e-11 mirMAP -0.22213369773385 0.000303981788598836 NA NA NA hsa-miR-10b-5p WNT7B -3.08172917642729 4.22675074435126e-09 6.45833028681074 1.2743062072308e-11 mirMAP -0.465142626600515 7.06702462289464e-06 NA NA NA hsa-miR-491-5p WNT7B 0.569358547192776 0.313310594748302 6.45833028681074 1.2743062072308e-11 mirMAP -0.330184477241142 0.00107310673487806 NA NA NA hsa-miR-505-3p WNT7B 0.58881333170866 0.226937454637888 6.45833028681074 1.2743062072308e-11 miRNATAP -0.344371689601171 0.00293288321292057 NA NA NA hsa-miR-148a-3p WNT9A 1.1031350648218 0.052038169812979 -1.18407404695739 0.266101963440536 mirMAP -0.432898371967406 4.26603455945752e-05 NA NA NA hsa-miR-148b-3p WNT9A 1.75622244535669 8.84414356040579e-08 -1.18407404695739 0.266101963440536 mirMAP -0.87883765663712 1.34304427585441e-06 NA NA NA hsa-miR-32-5p WNT9A 2.93035124381469 5.00149131394151e-10 -1.18407404695739 0.266101963440536 mirMAP -0.363977517670086 0.00367377284132333 NA NA NA hsa-miR-331-3p WNT9A 2.60769294751513 3.84318952029483e-07 -1.18407404695739 0.266101963440536 mirMAP -0.356933157833057 0.00205063036870332 NA NA NA hsa-miR-335-5p WNT9A 0.167216045757305 0.803897055331049 -1.18407404695739 0.266101963440536 miRNAWalker2_validate -0.317725285709137 0.000385124583476028 NA NA NA hsa-miR-589-3p WNT9A 1.33205316880069 0.052632683806148 -1.18407404695739 0.266101963440536 mirMAP -0.360413992507261 3.93582105522619e-05 NA NA NA hsa-miR-96-5p WNT9A 5.62521466029286 1.54938806718028e-10 -1.18407404695739 0.266101963440536 mirMAP -0.234533115491296 0.00400004958215225 NA NA NA