miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-93-3p ABHD15 -0.40282112910759 0.00131324842735598 1.30485636745917 1.43347474031276e-12 MirTarget -0.188238620809142 0.0107270997278665 NA NA NA hsa-miR-93-3p ABHD2 -0.40282112910759 0.00131324842735598 1.20462139360653 3.09717296882353e-15 mirMAP -0.293247041979908 1.49596808798407e-06 NA NA NA hsa-miR-93-3p ACSL1 -0.40282112910759 0.00131324842735598 2.33415071716028 1.71568734924885e-22 miRNAWalker2_validate -0.443918008813979 5.31262500294431e-06 NA NA NA hsa-miR-93-3p ADAMTSL2 -0.40282112910759 0.00131324842735598 2.67517409842879 2.54023880196414e-15 mirMAP -0.378126026616865 0.00555500675925019 NA NA NA hsa-miR-145-5p ADM2 1.47958857114771 6.4730836154326e-16 -1.7229047600607 3.16835442282694e-11 mirMAP -0.169878628502872 0.0129484299634377 NA NA NA hsa-miR-93-3p AIF1L -0.40282112910759 0.00131324842735598 -0.760588382527055 0.000504850655733501 MirTarget -0.202278007853046 0.0182259281657484 NA NA NA hsa-miR-93-3p AKAP11 -0.40282112910759 0.00131324842735598 0.701109462996848 1.06142032029725e-10 MirTarget -0.199352298377675 3.15184486356555e-06 NA NA NA hsa-miR-145-5p ALDH3A1 1.47958857114771 6.4730836154326e-16 -1.59783536227 0.0147986570586826 miRNAWalker2_validate -0.421250352530411 0.0126242297102388 NA NA NA hsa-miR-145-5p ANGPT2 1.47958857114771 6.4730836154326e-16 -1.15268392731739 7.05586126458069e-10 MirTarget;miRNATAP -0.196630651852303 5.50134414980236e-05 24384875;27570490 miR 145 functions as tumor suppressor and targets two oncogenes ANGPT2 and NEDD9 in renal cell carcinoma; We further validated those miR-145 targets two oncogenes ANGPT2 and NEDD9 in RCC;MiR 145 functions as a tumor suppressor via regulating angiopoietin 2 in pancreatic cancer cells; The direct action of miR-145 on Ang-2 was predicted by TargetScan and confirmed by luciferase report assay; The expression level of miR-145 was significantly lower and the expression levels of Ang-2 mRNA and protein was significantly higher in the more aggressive pancreatic cancer cells MiaPaCa-2 and Panc-1 when compared to that in BxPC3 cells; Overexpression of miR-145 in the BxPC3 MiaPaCa-2 and Panc-1 cells suppressed the cell invasion and colony formation ability and the expression level of Ang-2 protein in MiaPaCa-2 and Panc-1 cells was also suppressed after pre-miR-145 transfection; Intratumoral delivery of miR-145 inhibited the growth of pancreatic cancer xenografts and angiogenesis in vivo and also suppressed the expression level of angiopoietin-2 protein; MiR-145 functions as a tumor suppressor in pancreatic cancer cells by targeting Ang-2 for translation repression and thus suppresses pancreatic cancer cell invasion and growth which suggests that restoring of miR-145 may be a potential therapeutic target for pancreatic cancer ; kidney renal cell cancer;pancreatic cancer hsa-miR-93-3p ANKFY1 -0.40282112910759 0.00131324842735598 0.584743032032303 3.59707140040291e-12 mirMAP -0.189493928416605 9.14237084584224e-09 NA NA NA hsa-miR-145-5p ANKRD52 1.47958857114771 6.4730836154326e-16 -1.45719998646575 1.7473771080511e-36 miRNATAP -0.197085056637391 5.90538468792844e-10 NA NA NA hsa-miR-93-3p AOAH -0.40282112910759 0.00131324842735598 1.15877069643171 1.47625645766644e-06 MirTarget -0.241288638504864 0.0109906588354579 NA NA NA hsa-miR-93-3p AP3S2 -0.40282112910759 0.00131324842735598 0.334623387305725 3.54194346710983e-05 mirMAP -0.138964263268752 9.47655691595486e-06 NA NA NA hsa-miR-145-5p APH1A 1.47958857114771 6.4730836154326e-16 -0.326774606842123 7.14438841064691e-06 miRNAWalker2_validate -0.104983163859547 1.37106129803436e-08 NA NA NA hsa-miR-93-3p ARID4A -0.40282112910759 0.00131324842735598 0.895975441173608 4.13512367982319e-14 MirTarget -0.118115236521417 0.0130911188572856 NA NA NA hsa-miR-93-3p ARIH1 -0.40282112910759 0.00131324842735598 0.131545607366658 0.0699251677277513 MirTarget -0.13452024028027 1.31853546876596e-06 NA NA NA hsa-miR-93-3p ARSD -0.40282112910759 0.00131324842735598 1.15703048361888 2.52321723033546e-14 mirMAP -0.258166330213402 2.05202902877612e-05 NA NA NA hsa-miR-93-3p ASB7 -0.40282112910759 0.00131324842735598 0.19973877884458 0.0092747784764421 miRNATAP -0.108729942493653 0.000248478485587407 NA NA NA hsa-miR-425-3p ATMIN 0.156722391026837 0.22372009845904 0.371002750700504 5.51678829659323e-08 miRNAWalker2_validate -0.126186997691021 1.17707698129746e-06 NA NA NA hsa-miR-93-3p ATRN -0.40282112910759 0.00131324842735598 -0.118407208623316 0.341728688804821 MirTarget -0.102469968645806 0.03432742789638 NA NA NA hsa-miR-145-5p ATXN7L3 1.47958857114771 6.4730836154326e-16 -0.698895357070852 3.23244219063132e-16 miRNATAP -0.11885837536839 1.20279951756195e-07 NA NA NA hsa-miR-93-3p BMPR2 -0.40282112910759 0.00131324842735598 0.735692104466335 2.00485450351128e-12 miRNAWalker2_validate -0.19142388334342 3.75720841597008e-06 NA NA NA hsa-miR-93-3p BNC2 -0.40282112910759 0.00131324842735598 0.388487485712339 0.089728520979817 miRNATAP -0.328820413339454 0.000212458965786495 NA NA NA hsa-miR-145-5p BNIP3 1.47958857114771 6.4730836154326e-16 0.56708142845002 7.50287944629106e-06 miRNAWalker2_validate;miRTarBase -0.102031222082163 0.00183773459195118 20332243 Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death; Analysis of prostate cancer n = 134 and benign prostate n = 83 tissue sample showed significantly decreased miR145 and increased BNIP3 expression in prostate cancer P < 0.001 particularly in those with tumor progression and both molecular changes were associated with unfavorable outcome progression prostate cancer hsa-miR-145-5p BRWD3 1.47958857114771 6.4730836154326e-16 -0.0973893435145354 0.536703137535809 miRNATAP -0.113245543675398 0.00503839188312108 NA NA NA hsa-miR-145-5p BSN 1.47958857114771 6.4730836154326e-16 -0.943588815475765 2.35563209281755e-05 miRNATAP -0.271542646074543 2.15319194909084e-06 NA NA NA hsa-miR-93-3p C17orf51 -0.40282112910759 0.00131324842735598 0.666308125870991 0.00164334391334099 mirMAP -0.215886861077979 0.00908390676689397 NA NA NA hsa-miR-93-3p CACNA1C -0.40282112910759 0.00131324842735598 -0.946440250430891 1.06436399202532e-05 mirMAP -0.346247715057671 3.74998541285938e-05 NA NA NA hsa-miR-93-3p CACNB2 -0.40282112910759 0.00131324842735598 0.29382108956174 0.151148181646887 MirTarget;miRNATAP -0.194886056315352 0.0144586707594477 NA NA NA hsa-miR-93-3p CAMK1D -0.40282112910759 0.00131324842735598 0.401457997700563 0.123544927768405 mirMAP -0.447500462566269 8.84794026120713e-06 NA NA NA hsa-miR-93-3p CBR1 -0.40282112910759 0.00131324842735598 0.129648584005807 0.462231455904603 miRNAWalker2_validate -0.292896238515056 1.68133081772684e-05 NA NA NA hsa-miR-93-3p CCDC113 -0.40282112910759 0.00131324842735598 0.246871340455217 0.303122188278182 mirMAP -0.274790526981281 0.00317728596070854 NA NA NA hsa-miR-93-3p CCDC69 -0.40282112910759 0.00131324842735598 0.782491490067007 2.74271120883877e-06 mirMAP -0.2444529028704 0.000185562822541332 NA NA NA hsa-miR-145-5p CDK4 1.47958857114771 6.4730836154326e-16 -0.667631464196616 2.00897661385612e-11 miRNAWalker2_validate;miRTarBase -0.153089865179612 2.59222750442516e-09 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control lung squamous cell cancer hsa-miR-145-5p CEP78 1.47958857114771 6.4730836154326e-16 -0.348753889923127 0.00103957272277991 mirMAP -0.107147503186646 8.35016545422898e-05 NA NA NA hsa-miR-93-3p CGNL1 -0.40282112910759 0.00131324842735598 0.689721441130922 0.000385211746522735 mirMAP -0.208800604972498 0.00603227843046705 NA NA NA hsa-miR-93-3p CLN8 -0.40282112910759 0.00131324842735598 0.897397341277568 2.6962794902644e-12 mirMAP -0.115988161558893 0.0238338336453903 NA NA NA hsa-miR-93-3p COL4A3BP -0.40282112910759 0.00131324842735598 0.613641621350789 2.25554083957475e-14 MirTarget -0.172077938937991 5.98026595484597e-08 NA NA NA hsa-miR-145-5p COMMD5 1.47958857114771 6.4730836154326e-16 -0.838104876299822 1.81629659072031e-13 MirTarget -0.158374405731816 9.69916467666398e-08 NA NA NA hsa-miR-145-5p COMMD9 1.47958857114771 6.4730836154326e-16 -0.249145378307769 0.00304963862513739 MirTarget -0.102676427844162 1.55463217892546e-06 NA NA NA hsa-miR-93-3p CPEB2 -0.40282112910759 0.00131324842735598 0.777113534730001 2.25740559168515e-08 miRNATAP -0.205944892931299 0.000168185251910523 NA NA NA hsa-miR-93-3p CPNE8 -0.40282112910759 0.00131324842735598 0.764323108203913 3.17718650291343e-08 MirTarget;miRNATAP -0.214107085174137 8.16345090916968e-05 NA NA NA hsa-miR-93-3p CPS1 -0.40282112910759 0.00131324842735598 2.84602081185042 1.57139356169637e-08 MirTarget -1.14129708425276 6.16286326965482e-09 NA NA NA hsa-miR-93-3p CREB3L3 -0.40282112910759 0.00131324842735598 1.30003732784553 1.11329047056976e-05 mirMAP -0.302525304679396 0.0093345004910047 NA NA NA hsa-miR-93-3p CUX1 -0.40282112910759 0.00131324842735598 0.187927348104613 0.0398134377996086 mirMAP -0.13988733104399 7.41861077393268e-05 NA NA NA hsa-miR-93-3p CXorf23 -0.40282112910759 0.00131324842735598 -0.430761186308625 9.49129189428522e-06 miRNATAP -0.133248088123045 0.000455320201730869 NA NA NA hsa-miR-93-3p DCAF8 -0.40282112910759 0.00131324842735598 0.0265942497922635 0.751662897530472 MirTarget -0.152628463028504 2.16331144014422e-06 NA NA NA hsa-miR-93-3p DDI2 -0.40282112910759 0.00131324842735598 1.53096229477393 2.81259482387215e-06 MirTarget -0.300832141535694 0.0195757064776843 NA NA NA hsa-miR-93-3p DLG2 -0.40282112910759 0.00131324842735598 1.94736926226419 3.34813832074829e-14 MirTarget;miRNATAP -0.545495539293013 8.74222185854571e-08 NA NA NA hsa-miR-145-5p DNAJB11 1.47958857114771 6.4730836154326e-16 -0.853927523668175 2.13811491659019e-21 miRNATAP -0.144186737048418 1.37168338108303e-09 NA NA NA hsa-miR-93-3p DNAJC27 -0.40282112910759 0.00131324842735598 0.350802101061358 0.000255703839327473 MirTarget -0.146919618561162 8.08685018898981e-05 NA NA NA hsa-miR-145-5p DNMT3B 1.47958857114771 6.4730836154326e-16 -1.61793226634891 7.24162651287182e-19 MirTarget -0.229217111222152 2.31179911359625e-06 24071015;25749421 In univariate analysis the combination of DNMT3B overexpression and miR-145 or miR-143 down-regulation was more powerful in predicting shorter survival P < .05 than use of the biomarkers individually P > .05; DNMT3B might be a potential target of miR-145 and miR-143 in ECs; Furthermore the combined miR-145 or miR-143 and DNMT3B status may have a prognostic impact on ECs;It was found that miR-145 upregulates while DNMT3b downregulates in PC3 cells; Responses of the miR-145 and DNMT3b to irradiation are a negative correlation; We also found that either overexpression of miR-145 or knockdown of DNMT3b sensitized prostate cancer cells to X-ray radiation poor survival;drug resistance endometrial cancer;prostate cancer hsa-miR-425-3p DUSP1 0.156722391026837 0.22372009845904 2.0215708216874 6.14519109294446e-23 MirTarget -0.32709277907136 6.7075970426446e-05 NA NA NA hsa-miR-145-5p EFNA3 1.47958857114771 6.4730836154326e-16 -1.74857523726189 1.89670377349905e-17 miRNATAP -0.27893442549449 2.94867753331604e-07 NA NA NA hsa-miR-93-3p EML1 -0.40282112910759 0.00131324842735598 0.628864626308181 0.000194859905761291 MirTarget -0.245222803674677 0.000195715401316781 NA NA NA hsa-miR-93-3p EMP2 -0.40282112910759 0.00131324842735598 0.296192757013701 0.0244099527389391 mirMAP -0.161365302762962 0.00160340389510766 NA NA NA hsa-miR-93-3p EPHA3 -0.40282112910759 0.00131324842735598 1.75532340990487 1.13157153732927e-08 MirTarget -0.572903086308206 2.08493358777909e-06 NA NA NA hsa-miR-145-5p ERF 1.47958857114771 6.4730836154326e-16 -0.136389282321138 0.14928452616067 MirTarget;miRNATAP -0.111839765842692 3.1225859006542e-06 NA NA NA hsa-miR-145-5p ESCO2 1.47958857114771 6.4730836154326e-16 -1.79795026822267 1.40192339916997e-14 MirTarget -0.350922169188005 9.21748412277187e-09 NA NA NA hsa-miR-145-5p FAM104A 1.47958857114771 6.4730836154326e-16 -0.382548867340033 2.14628142056207e-09 MirTarget -0.135312338302984 2.50383248700923e-17 NA NA NA hsa-miR-145-5p FAM134A 1.47958857114771 6.4730836154326e-16 -0.312419862710707 6.33121602143631e-06 MirTarget -0.106729178144281 1.11245752196109e-09 NA NA NA hsa-miR-145-5p FAM49B 1.47958857114771 6.4730836154326e-16 -0.70628378339655 6.55052138725191e-10 MirTarget -0.110874561653967 0.000199701932460406 NA NA NA hsa-miR-93-3p FETUB -0.40282112910759 0.00131324842735598 2.79762076873662 4.63943625565446e-10 MirTarget -0.490455972451486 0.00603326461949916 NA NA NA hsa-miR-93-3p FGF2 -0.40282112910759 0.00131324842735598 1.08625533231299 0.000324809942833159 mirMAP -0.437085459323848 0.000209985380897254 NA NA NA hsa-miR-93-3p FKBP5 -0.40282112910759 0.00131324842735598 0.232073250029762 0.194203332017952 miRNAWalker2_validate -0.222855675903197 0.00131733257137818 NA NA NA hsa-miR-145-5p FLRT1 1.47958857114771 6.4730836154326e-16 -1.04778256475981 1.23585074123515e-06 MirTarget -0.171014510051033 0.00230060297365636 NA NA NA hsa-miR-93-3p FOSL2 -0.40282112910759 0.00131324842735598 0.435467547734664 0.00385233400608026 mirMAP -0.172113266868538 0.00339256015185962 NA NA NA hsa-miR-93-3p FTO -0.40282112910759 0.00131324842735598 0.232812028117052 0.00922973083936809 mirMAP -0.178458252553844 2.04046112261211e-07 NA NA NA hsa-miR-93-3p FYN -0.40282112910759 0.00131324842735598 1.05543942235431 1.10191754676925e-15 miRNAWalker2_validate -0.289456631335079 3.21118215920667e-08 NA NA NA hsa-miR-93-3p GAB3 -0.40282112910759 0.00131324842735598 0.33894064434514 0.0197446260921706 MirTarget -0.21414683263157 0.00014585554050311 NA NA NA hsa-miR-425-3p GABPB2 0.156722391026837 0.22372009845904 -0.8104559893402 3.81209247158571e-10 miRNAWalker2_validate -0.116522262262922 0.0206185810143317 NA NA NA hsa-miR-145-5p GATC 1.47958857114771 6.4730836154326e-16 -0.0603112190540133 0.626598180192356 MirTarget -0.115253801141523 0.00026725465713453 NA NA NA hsa-miR-93-3p GCAT -0.40282112910759 0.00131324842735598 0.890075815629737 2.3052355261354e-05 miRNAWalker2_validate -0.18621657526883 0.0243165570447074 NA NA NA hsa-miR-93-3p GDF2 -0.40282112910759 0.00131324842735598 8.69657411537159 1.29312595933194e-70 MirTarget -0.78289493960907 0.000546869173007837 NA NA NA hsa-miR-93-3p GFOD1 -0.40282112910759 0.00131324842735598 0.739136473829969 1.5414433660947e-06 mirMAP -0.307570861037763 2.77067427874983e-07 NA NA NA hsa-miR-145-5p GGT7 1.47958857114771 6.4730836154326e-16 -0.0215459775862454 0.846767823094601 MirTarget;miRNATAP -0.105884657657048 0.000193581797365303 NA NA NA hsa-miR-93-3p GIMAP1 -0.40282112910759 0.00131324842735598 0.323612806589388 0.0243616911333046 mirMAP -0.300960017842499 5.03994475201924e-08 NA NA NA hsa-miR-93-3p GIPC3 -0.40282112910759 0.00131324842735598 -0.206459172969287 0.115516845743804 mirMAP -0.268091497307539 1.00666630737964e-07 NA NA NA hsa-miR-93-3p GLUD1 -0.40282112910759 0.00131324842735598 1.37160912989457 3.12853087299215e-16 miRNAWalker2_validate -0.172707825239591 0.0109352698248146 NA NA NA hsa-miR-93-3p GNAO1 -0.40282112910759 0.00131324842735598 3.67315176204714 3.16748155044873e-21 mirMAP -0.586587880723669 0.000215507669428987 NA NA NA hsa-miR-93-3p GOT2 -0.40282112910759 0.00131324842735598 1.21668251154194 1.85435926286412e-17 miRNAWalker2_validate -0.346271056064403 1.20254487758613e-09 NA NA NA hsa-miR-93-3p GPD1 -0.40282112910759 0.00131324842735598 2.61322405001312 1.93177757503559e-15 miRNATAP -0.504238932809296 0.000135498143117631 NA NA NA hsa-miR-145-5p GPD2 1.47958857114771 6.4730836154326e-16 -0.40456731808886 0.00037434440323501 miRNATAP -0.103572173689072 0.000393560251461817 NA NA NA hsa-miR-145-5p H2AFX 1.47958857114771 6.4730836154326e-16 -1.27255391641287 1.24796507414313e-17 MirTarget;miRNATAP -0.247226192426532 2.41220424161681e-10 NA NA NA hsa-miR-93-3p H6PD -0.40282112910759 0.00131324842735598 0.159284401461313 0.269264574065668 mirMAP -0.126499549173036 0.0240956145079998 NA NA NA hsa-miR-93-3p HACL1 -0.40282112910759 0.00131324842735598 0.460987768415968 0.000123393454275912 miRNAWalker2_validate -0.126848239402547 0.00693816092535651 NA NA NA hsa-miR-93-3p HDX -0.40282112910759 0.00131324842735598 0.72710745748536 0.00193923996731703 MirTarget -0.271339738075962 0.00305768020775425 NA NA NA hsa-miR-93-3p HEG1 -0.40282112910759 0.00131324842735598 -0.175697577625919 0.209861547402421 mirMAP -0.162966951551391 0.00272821667379635 NA NA NA hsa-miR-93-3p HHIPL1 -0.40282112910759 0.00131324842735598 0.6627728247093 0.00091593565977199 mirMAP -0.160478817368478 0.0404833203325848 NA NA NA hsa-miR-145-5p HIC2 1.47958857114771 6.4730836154326e-16 -0.940776893137957 6.46839631810609e-09 miRNATAP -0.201910123438837 1.50163181272437e-06 NA NA NA hsa-miR-145-5p HLTF 1.47958857114771 6.4730836154326e-16 -0.436017063558851 0.000150608395187145 miRNAWalker2_validate -0.128421100653523 1.3235123890904e-05 25666710 We show that miR-145 targets the DNA damage repair-associated gene Helicase-like transcription factor HLTF which is involved in radio-resistance drug resistance cervical and endocervical cancer hsa-miR-93-3p HSPG2 -0.40282112910759 0.00131324842735598 -0.547232003403171 0.000340016191663106 mirMAP -0.144537249360934 0.0156675413826462 NA NA NA hsa-miR-93-3p IKZF1 -0.40282112910759 0.00131324842735598 0.973272492309266 4.90450525854252e-07 mirMAP -0.220776206987876 0.00379146618148337 NA NA NA hsa-miR-93-3p IKZF2 -0.40282112910759 0.00131324842735598 0.832526663086802 1.47171329778731e-05 MirTarget;miRNATAP -0.177280922881689 0.0189720257351178 NA NA NA hsa-miR-93-3p IL6ST -0.40282112910759 0.00131324842735598 1.91925864959166 1.59476897276323e-08 MirTarget -0.544072709623523 4.78743772126621e-05 NA NA NA hsa-miR-145-5p IRS1 1.47958857114771 6.4730836154326e-16 0.22138394823895 0.137544848662308 miRNAWalker2_validate;miRTarBase;MirTarget -0.14713831440926 0.000110683183121748 22431718;24690171;24762580 Luciferase reporter assay further verified direct target association of miR-145 to specific sites of the IRS1 and IRS2 3'-untranslated regions;MicroRNA 145 suppresses hepatocellular carcinoma by targeting IRS1 and its downstream Akt signaling; We verified IRS1 as a direct target of miR-145 using Western blotting and luciferase reporter assay; Further the restoration of miR-145 in HCC cell lines suppressed cancer cell growth owing to down-regulated IRS1 expression and its downstream Akt/FOXO1 signaling; Our results demonstrated that miR-145 could inhibit HCC through targeting IRS1 and its downstream signaling implicating the loss of miR-145 regulation may be a potential molecular mechanism causing aberrant oncogenic signaling in HCC;IRS-1 was identified as a potential target of miR-145 by dual luciferase reporter assay; Knocking down of IRS-1 had similar effect as overexpression of miR-145 miR-145 might act as a tumor suppressor in uveal melanoma and downregulation of the target IRS-1 might be a potential mechanism ;; liver cancer;liver cancer;melanoma hsa-miR-93-3p ITPRIP -0.40282112910759 0.00131324842735598 0.927133985910503 1.56065524462961e-11 miRNAWalker2_validate -0.398833370017486 7.03292446270067e-14 NA NA NA hsa-miR-93-3p ITSN1 -0.40282112910759 0.00131324842735598 0.745784549212655 1.16990524702221e-11 mirMAP -0.132014412380117 0.00255165714631976 NA NA NA hsa-miR-93-3p KCTD15 -0.40282112910759 0.00131324842735598 0.0430097733946191 0.834208685250742 mirMAP -0.163106916626354 0.0414421549063885 NA NA NA hsa-miR-93-3p KIAA1644 -0.40282112910759 0.00131324842735598 1.81284684066633 3.23319427628108e-09 mirMAP -0.514749983989385 2.02222498596534e-05 NA NA NA hsa-miR-93-3p KIAA1671 -0.40282112910759 0.00131324842735598 0.839733934948399 1.10952867050443e-11 miRNAWalker2_validate -0.286668946073289 3.38928226037678e-09 NA NA NA hsa-miR-93-3p KIRREL -0.40282112910759 0.00131324842735598 0.920556464539881 0.00842298893942037 mirMAP -0.350874377056737 0.0101297297974783 NA NA NA hsa-miR-93-3p KLF12 -0.40282112910759 0.00131324842735598 0.863221902725631 5.41423508072649e-09 MirTarget;mirMAP -0.187623839557976 0.001343396765116 NA NA NA hsa-miR-93-3p KLF9 -0.40282112910759 0.00131324842735598 1.35905833834713 1.22932810880226e-12 miRNATAP -0.533454217493069 8.80424276171002e-13 NA NA NA hsa-miR-425-3p KLHL15 0.156722391026837 0.22372009845904 1.43616317329618 4.62856180062131e-29 miRNAWalker2_validate -0.113377731784612 0.0307721295073287 NA NA NA hsa-miR-93-3p KLHL2 -0.40282112910759 0.00131324842735598 1.16669881935719 4.68056312110121e-18 miRNATAP -0.290251652503751 7.42322657278603e-08 NA NA NA hsa-miR-93-3p KLHL30 -0.40282112910759 0.00131324842735598 -0.895949587241132 0.00134548195866904 mirMAP -0.248756476281748 0.0230111437822837 NA NA NA hsa-miR-93-3p KLRD1 -0.40282112910759 0.00131324842735598 1.83144193603113 1.51189909857633e-14 MirTarget -0.391746286420777 3.97270084503783e-05 NA NA NA hsa-miR-93-3p LAX1 -0.40282112910759 0.00131324842735598 0.861666859265147 0.000234679054557368 MirTarget -0.185586108447077 0.0435484757337766 NA NA NA hsa-miR-93-3p LCOR -0.40282112910759 0.00131324842735598 0.828225234134718 0.000381975258357081 miRNATAP -0.269976888039832 0.00307727343589214 NA NA NA hsa-miR-93-3p LRBA -0.40282112910759 0.00131324842735598 0.505199459574334 1.1773549213128e-06 miRNAWalker2_validate -0.105384885613626 0.00993598891577419 NA NA NA hsa-miR-93-3p LRRC27 -0.40282112910759 0.00131324842735598 -0.176229303358834 0.0993499250075712 mirMAP -0.106207772575605 0.0105547741478183 NA NA NA hsa-miR-93-3p LRRC34 -0.40282112910759 0.00131324842735598 0.1319499010402 0.228811025945286 miRNAWalker2_validate -0.104911710677329 0.0137302526083782 NA NA NA hsa-miR-93-3p LYRM7 -0.40282112910759 0.00131324842735598 0.285114105890551 0.000746869763807209 mirMAP -0.100178789366833 0.00232442118023086 NA NA NA hsa-miR-145-5p MAGOHB 1.47958857114771 6.4730836154326e-16 -0.39509058223687 1.17195156112121e-05 MirTarget -0.106370939048142 4.11350109311863e-06 NA NA NA hsa-miR-93-3p MAN1C1 -0.40282112910759 0.00131324842735598 2.43169678885209 2.06495307195247e-21 MirTarget -0.544345470219828 1.49303603579671e-07 NA NA NA hsa-miR-145-5p MAP2K6 1.47958857114771 6.4730836154326e-16 -0.144298636980367 0.551123536879766 miRNAWalker2_validate -0.148422069176077 0.0169211009425297 NA NA NA hsa-miR-93-3p MAP9 -0.40282112910759 0.00131324842735598 1.37818477884312 4.17865186099978e-07 MirTarget -0.309186460363641 0.00399557287004076 NA NA NA hsa-miR-145-5p MBNL3 1.47958857114771 6.4730836154326e-16 0.597245834128656 0.014237987148395 miRNATAP -0.194260062903799 0.00191805665901708 NA NA NA hsa-miR-425-3p MDH2 0.156722391026837 0.22372009845904 -0.0705623377515803 0.507538609177707 miRNAWalker2_validate -0.126735523788599 0.00166757070903881 NA NA NA hsa-miR-93-3p MID2 -0.40282112910759 0.00131324842735598 -0.0174599820031887 0.916108111203449 MirTarget -0.333591500143212 1.5607733252131e-07 NA NA NA hsa-miR-93-3p MKL2 -0.40282112910759 0.00131324842735598 -0.0186170121960809 0.857399442963323 MirTarget -0.154041318149283 0.000116245311162576 NA NA NA hsa-miR-145-5p MMP1 1.47958857114771 6.4730836154326e-16 -1.71035043682945 7.54233897842311e-06 miRNAWalker2_validate -0.212014152453586 0.0327763086187393 NA NA NA hsa-miR-93-3p MOCS1 -0.40282112910759 0.00131324842735598 0.555657989620141 3.0914054039319e-05 miRNATAP -0.222075355937603 1.91240176913684e-05 NA NA NA hsa-miR-93-3p MON1B -0.40282112910759 0.00131324842735598 0.094371224994676 0.255339014596275 miRNAWalker2_validate -0.117709993927734 0.000233902382678733 NA NA NA hsa-miR-93-3p MPP5 -0.40282112910759 0.00131324842735598 0.288077654324145 0.00156212311296757 miRNAWalker2_validate -0.100313323845415 0.00466661098709339 NA NA NA hsa-miR-93-3p MPPED2 -0.40282112910759 0.00131324842735598 -0.656713801192978 0.0163326393553169 mirMAP -0.301337313230053 0.00470775638837253 NA NA NA hsa-miR-93-3p MTUS2 -0.40282112910759 0.00131324842735598 3.87506735751049 7.90907575593226e-24 miRNATAP -0.398555235825774 0.0121481136233516 NA NA NA hsa-miR-93-3p N4BP2L1 -0.40282112910759 0.00131324842735598 1.71399858767708 1.05172316331637e-27 MirTarget -0.299823640470702 3.78762242064963e-06 NA NA NA hsa-miR-93-3p NCOA1 -0.40282112910759 0.00131324842735598 0.411504065902961 3.78760215023854e-07 MirTarget;miRNATAP -0.129622454259351 4.17534612404641e-05 NA NA NA hsa-miR-93-3p NCOA4 -0.40282112910759 0.00131324842735598 0.700242506346023 3.72202231354768e-11 miRNAWalker2_validate -0.175081646417812 2.87860940208021e-05 NA NA NA hsa-miR-145-5p NEDD4L 1.47958857114771 6.4730836154326e-16 -0.864887679249783 8.63340597856728e-11 miRNATAP -0.226798274128155 3.48443162842019e-11 NA NA NA hsa-miR-93-3p NFAM1 -0.40282112910759 0.00131324842735598 1.5126511002004 1.93686430698692e-15 mirMAP -0.156137612844024 0.0423577223273634 NA NA NA hsa-miR-93-3p NFASC -0.40282112910759 0.00131324842735598 0.522066844629387 0.0155574931536181 MirTarget;miRNATAP -0.365744110201298 1.20154414356971e-05 NA NA NA hsa-miR-93-3p NFIA -0.40282112910759 0.00131324842735598 0.924685216157228 2.60745966246995e-13 miRNATAP -0.246790515298364 8.50899951857583e-07 NA NA NA hsa-miR-93-3p NFIC -0.40282112910759 0.00131324842735598 0.577436174020044 0.00748919731318249 mirMAP -0.325309139976327 0.00010499930500842 NA NA NA hsa-miR-425-3p NFIX 0.156722391026837 0.22372009845904 0.0507190853125863 0.707056383209165 mirMAP -0.365332502366734 2.29062720144819e-13 NA NA NA hsa-miR-93-3p NIT1 -0.40282112910759 0.00131324842735598 0.0254711807591299 0.791479149249332 miRNATAP -0.138650804102208 0.000191100302908308 NA NA NA hsa-miR-93-3p NLGN4X -0.40282112910759 0.00131324842735598 1.2760138670071 0.000397120705032195 MirTarget;miRNATAP -0.306361219198643 0.0301751842661988 NA NA NA hsa-miR-93-3p NPTXR -0.40282112910759 0.00131324842735598 0.560890830244133 0.097454187100738 mirMAP -0.334943730510752 0.0110732047559012 NA NA NA hsa-miR-145-5p NRAS 1.47958857114771 6.4730836154326e-16 -0.301156333096781 0.000285671613438277 miRNAWalker2_validate;MirTarget;miRNATAP -0.120395847533196 1.03194548202048e-08 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-145-5p NUDT1 1.47958857114771 6.4730836154326e-16 -1.54647799393357 9.79342763313015e-22 miRTarBase -0.230048769240889 9.45867065612913e-08 21289483 MiR 145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1; The mRNA expressions of EGFR and NUDT1 were significantly downregulated after miR-145 transfection in human lung adenocarcinoma cells; Our results demonstrated miR-145 in the negative regulation of EGFR and NUDT1 expressions at both mRNA and protein levels; Upregulation of miR-145 appeared to be an important gene regulation mechanism for the proliferation of lung adenocarcinoma cells and it correlated strongly with the downregulation of EGFR and NUDT1; Our findings provided new insight into the complex regulating pathway comprising of miR-145 EGFR NUDT1 and other unknown factors which function in cell proliferation but not in apoptosis lung cancer hsa-miR-93-3p OCIAD1 -0.40282112910759 0.00131324842735598 0.363945364154923 2.88737977727406e-07 miRNATAP -0.115357063883693 3.01773360384704e-05 NA NA NA hsa-miR-145-5p ONECUT2 1.47958857114771 6.4730836154326e-16 -0.120890541524139 0.551384233388773 mirMAP;miRNATAP -0.24786103208335 1.51819604606623e-06 NA NA NA hsa-miR-93-3p PAFAH1B1 -0.40282112910759 0.00131324842735598 0.434065106493071 1.9305396142455e-10 MirTarget;miRNATAP -0.15593811518163 4.06292567514066e-09 NA NA NA hsa-miR-145-5p PAK4 1.47958857114771 6.4730836154326e-16 -0.332066945941023 0.000554855795687723 miRNAWalker2_validate;miRTarBase -0.118651468400972 1.29791519135524e-06 23499891 We further demonstrated that miR-145 directly targeted catenin δ-1 contributing to the aberrant translocation of β-catenin through impaired nuclear shuttling with p21-activated kinase 4 PAK4 colon cancer hsa-miR-93-3p PAMR1 -0.40282112910759 0.00131324842735598 2.87061788123775 5.98608474034552e-37 miRNAWalker2_validate -0.421984073656612 1.0448336022796e-05 NA NA NA hsa-miR-145-5p PAN2 1.47958857114771 6.4730836154326e-16 0.124303685559882 0.245125336020723 MirTarget;miRNATAP -0.123876289466467 5.05781336675732e-06 NA NA NA hsa-miR-145-5p PAQR9 1.47958857114771 6.4730836154326e-16 -0.136400501110992 0.512160863858603 MirTarget -0.200402389306194 0.000162310204296034 NA NA NA hsa-miR-93-3p PDLIM2 -0.40282112910759 0.00131324842735598 0.897556099359773 5.80962825020712e-13 mirMAP -0.185245783015617 0.000190319498245776 NA NA NA hsa-miR-145-5p PIGF 1.47958857114771 6.4730836154326e-16 -0.461843025560524 5.00720811835561e-10 miRNAWalker2_validate;MirTarget -0.122104310407385 1.24852987743285e-10 NA NA NA hsa-miR-93-3p PITPNA -0.40282112910759 0.00131324842735598 0.561422250138187 5.84350967535687e-12 mirMAP;miRNATAP -0.125489922012667 0.000101959353142566 NA NA NA hsa-miR-93-3p PLIN4 -0.40282112910759 0.00131324842735598 0.620639263168915 0.00737541247376377 mirMAP -0.258742178808353 0.00418703390475527 NA NA NA hsa-miR-93-3p PLXNA4 -0.40282112910759 0.00131324842735598 2.32968209214848 9.44050955139234e-10 miRNATAP -0.41140825977975 0.00656016537695858 NA NA NA hsa-miR-93-3p PODXL -0.40282112910759 0.00131324842735598 -1.44094860371079 1.88695975215801e-18 mirMAP -0.192588730435613 0.00392055642768628 NA NA NA hsa-miR-145-5p POU5F1 1.47958857114771 6.4730836154326e-16 -1.70826814451959 3.08759036385533e-10 miRNAWalker2_validate -0.28116277943052 7.30785404553878e-05 NA NA NA hsa-miR-425-3p PPARGC1A 0.156722391026837 0.22372009845904 1.91181447721978 1.53762022606375e-08 miRNAWalker2_validate -0.512460197382103 8.40656682857814e-05 NA NA NA hsa-miR-93-3p PPM1B -0.40282112910759 0.00131324842735598 0.275687173108444 0.000442253436356126 miRNATAP -0.143333737128232 2.20453008395152e-06 NA NA NA hsa-miR-93-3p PPP1R12B -0.40282112910759 0.00131324842735598 0.400775560101387 0.000211934336132351 mirMAP -0.252090217638757 1.2996804692573e-09 NA NA NA hsa-miR-93-3p PPP1R16B -0.40282112910759 0.00131324842735598 0.425828485523823 0.0160600622452052 MirTarget;miRNATAP -0.264542353280661 0.000115824587968982 NA NA NA hsa-miR-93-3p PPP3CA -0.40282112910759 0.00131324842735598 0.536165287387851 2.77787023947602e-11 miRNATAP -0.143288165599429 6.27730698290466e-06 NA NA NA hsa-miR-93-3p PSD3 -0.40282112910759 0.00131324842735598 1.20252145080478 1.1986832201197e-09 MirTarget -0.431332299167826 2.54630544879055e-08 NA NA NA hsa-miR-93-3p PTAFR -0.40282112910759 0.00131324842735598 1.09310705134362 5.89106187451208e-06 mirMAP -0.218134577717151 0.0217226256214237 NA NA NA hsa-miR-145-5p RAB11FIP4 1.47958857114771 6.4730836154326e-16 -1.54437373311846 7.02562100479356e-17 MirTarget -0.186591780130354 0.000149212740508188 NA NA NA hsa-miR-93-3p RAPGEF3 -0.40282112910759 0.00131324842735598 -0.817125994246766 4.45573187890566e-08 mirMAP -0.221355298684382 0.000165822435634208 NA NA NA hsa-miR-93-3p RBM47 -0.40282112910759 0.00131324842735598 0.580007397723856 2.64624683422125e-07 MirTarget -0.136561438656198 0.00206654876829265 NA NA NA hsa-miR-145-5p RNF207 1.47958857114771 6.4730836154326e-16 -0.828705825765606 2.83913644607006e-10 MirTarget -0.142373370880354 3.20402601721353e-05 NA NA NA hsa-miR-145-5p RNF216 1.47958857114771 6.4730836154326e-16 -0.524262170688949 6.99637163968206e-13 MirTarget;miRNATAP -0.121520852924876 1.01351446484376e-10 NA NA NA hsa-miR-93-3p RPS6KA2 -0.40282112910759 0.00131324842735598 0.429936688183555 0.00940192295734165 MirTarget -0.482383363283909 1.2839051401815e-14 NA NA NA hsa-miR-145-5p RPS6KB1 1.47958857114771 6.4730836154326e-16 -0.0405513114293417 0.579068505304808 MirTarget;miRNATAP -0.109724019103871 2.07298188703538e-09 24157791 MiR 145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1; MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3'UTRs; Importantly the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145 respectively; Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1 functioning as a tumor suppressor ovarian cancer hsa-miR-93-3p RUNDC3B -0.40282112910759 0.00131324842735598 1.77231643639114 1.97430239448798e-11 miRNAWalker2_validate -0.594862473111533 1.02424262174519e-08 NA NA NA hsa-miR-93-3p S1PR1 -0.40282112910759 0.00131324842735598 0.723869489322339 1.31811287279397e-06 MirTarget -0.354423740055155 9.07066007551751e-10 NA NA NA hsa-miR-145-5p SCAMP3 1.47958857114771 6.4730836154326e-16 -1.20056451579603 1.63329457117055e-29 MirTarget;miRNATAP -0.180821092204003 3.2493487591107e-10 NA NA NA hsa-miR-425-3p SEC31B 0.156722391026837 0.22372009845904 -0.577332943434117 0.00108506114985335 MirTarget -0.16049149461876 0.0176191172806467 NA NA NA hsa-miR-93-3p SEPSECS -0.40282112910759 0.00131324842735598 1.01697472631098 3.968743631321e-15 miRNATAP -0.28907265498365 1.80470088554843e-08 NA NA NA hsa-miR-93-3p SEPT11 -0.40282112910759 0.00131324842735598 0.271094902751821 0.00551196246724909 miRNATAP -0.108820254376268 0.00417634820824244 NA NA NA hsa-miR-93-3p SESN2 -0.40282112910759 0.00131324842735598 0.101007611720756 0.366158583982965 mirMAP -0.111257557760681 0.0103170716591193 NA NA NA hsa-miR-93-3p SETD7 -0.40282112910759 0.00131324842735598 0.645690628283924 3.04188071973914e-07 mirMAP -0.258524318447016 1.39009296618876e-07 NA NA NA hsa-miR-93-3p SFMBT2 -0.40282112910759 0.00131324842735598 0.653813685456886 0.0100525670943713 mirMAP -0.391354675513688 7.22786609296618e-05 NA NA NA hsa-miR-93-3p SH3RF3 -0.40282112910759 0.00131324842735598 -0.372077452583573 0.136814784242837 mirMAP -0.31977374421831 0.000992739550387853 NA NA NA hsa-miR-93-3p SIDT1 -0.40282112910759 0.00131324842735598 0.422483661613941 0.034150906727357 MirTarget -0.23558970003201 0.00239962325166096 NA NA NA hsa-miR-93-3p SLC1A2 -0.40282112910759 0.00131324842735598 2.05184743338734 5.07102901300139e-06 mirMAP;miRNATAP -0.712459514184956 5.21545924710996e-05 NA NA NA hsa-miR-145-5p SLC1A4 1.47958857114771 6.4730836154326e-16 -0.587017438973824 1.9059945976071e-05 MirTarget -0.221974664122985 1.8846965246477e-10 NA NA NA hsa-miR-93-3p SLC23A2 -0.40282112910759 0.00131324842735598 0.584703803315866 0.00102364040800048 miRNATAP -0.487375462212601 6.53052031164871e-13 NA NA NA hsa-miR-93-3p SLC25A23 -0.40282112910759 0.00131324842735598 0.0461797159631994 0.675271292742885 miRNAWalker2_validate -0.210726358325911 6.28377777929612e-07 NA NA NA hsa-miR-93-3p SLC9A3R2 -0.40282112910759 0.00131324842735598 0.895960756907259 1.34323434090931e-08 miRNATAP -0.257952221971799 3.23161992531284e-05 NA NA NA hsa-miR-93-3p SMPD3 -0.40282112910759 0.00131324842735598 2.39946548240761 3.07239513004396e-30 mirMAP -0.239843031000054 0.00643908011980701 NA NA NA hsa-miR-93-3p SNRK -0.40282112910759 0.00131324842735598 0.852628008928751 3.46352510534418e-18 miRNATAP -0.230050552729963 3.94941844947383e-09 NA NA NA hsa-miR-145-5p SNX15 1.47958857114771 6.4730836154326e-16 -0.572778806079485 3.12079483726911e-10 miRNATAP -0.15245259718236 6.11625813661806e-11 NA NA NA hsa-miR-145-5p SNX27 1.47958857114771 6.4730836154326e-16 -0.701282370576235 4.48665293424894e-15 MirTarget;miRNATAP -0.118723174339915 4.0542136039993e-07 NA NA NA hsa-miR-145-5p SOCS7 1.47958857114771 6.4730836154326e-16 -1.23630045260618 2.28814323600527e-14 miRNAWalker2_validate -0.201080343209046 2.31433808114246e-06 23392170 socs7 a target gene of microRNA 145 regulates interferon β induction through STAT3 nuclear translocation in bladder cancer cells; Then we focused on the suppressor of cytokine signaling 7 socs7 whose expression level was upregulated in bladder cancer cells compared with its level in normal human urothelial cells as a putative target gene involved in IFN-β induction by miR-145; Expectedly exogenous miR-145 decreased the expression level of SOCS7 and socs7-silencing enhanced IFN-β induction by transfection with a TLR3 ligand polyinosinic acid-polycytidylic acid PIC; The results of a luciferase reporter assay revealed that miR-145 targeted socs7; In conclusion the machinery of IFN-β induction through the regulation of SOCS7 by miR-145 was closely associated with the induction of apoptosis; Moreover exogenous miR-145 promoted IFN-β induction by targeting socs7 which resulted in the nuclear translocation of STAT3 bladder cancer hsa-miR-93-3p SORBS2 -0.40282112910759 0.00131324842735598 1.05178871500438 1.28000308624202e-08 MirTarget -0.430053201492821 2.31723391529441e-09 NA NA NA hsa-miR-145-5p SOX2 1.47958857114771 6.4730836154326e-16 -0.957482238879069 0.017078375832613 miRNAWalker2_validate;miRTarBase -0.232281038843592 0.0247688875246843 20382729;21211035;22098779;25951106;22835608 Finally we provide evidence that EWS-FLI-1 and miRNA-145 function in a mutually repressive feedback loop and identify their common target gene SOX2 in addition to miRNA145 itself as key players in ESFT cell differentiation and tumorigenicity;We also show that miR-145 and SOX2 form a double negative feedback loop in GBM cells potentially creating a bistable system in GBM cells;In this study our miRNA/mRNA-microarray and RT-PCR analysis showed that the expression of miR145 a tumor-suppressive miRNA is inversely correlated with the levels of Oct4 and Sox2 in GBM-CD133+ cells and malignant glioma specimens; We demonstrated that miR145 negatively regulates GBM tumorigenesis by targeting Oct4 and Sox2 in GBM-CD133+;Overexpression of miR 145 5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression; We proposed that miR-145-5p being an important regulator of SOX2 carries a crucial role in PCa tumorigenesis;miR-145 regulates SOX2 and OCT4 translation and p53 regulates miR-145 expression differentiation;;malignant trasformation;tumorigenesis;tumorigenesis; sarcoma;glioblastoma;glioblastoma;prostate cancer;lung squamous cell cancer hsa-miR-145-5p SPATS2 1.47958857114771 6.4730836154326e-16 -1.59671382425823 4.98846564542915e-42 MirTarget -0.250785060922859 1.06397318915935e-14 NA NA NA hsa-miR-145-5p SRGAP2 1.47958857114771 6.4730836154326e-16 -0.771567831540349 3.52407714516952e-11 MirTarget -0.121484336463963 6.57611803895429e-05 NA NA NA hsa-miR-93-3p ST3GAL1 -0.40282112910759 0.00131324842735598 0.767532914178662 6.27233158530235e-05 mirMAP -0.304755152632093 4.61367849576802e-05 NA NA NA hsa-miR-93-3p ST6GAL2 -0.40282112910759 0.00131324842735598 3.94296495109759 1.34875955382261e-24 MirTarget -0.566875085692784 0.000353901783862961 NA NA NA hsa-miR-93-3p STARD5 -0.40282112910759 0.00131324842735598 1.8318305227509 8.268739712357e-21 mirMAP -0.623051506391935 8.30248785924505e-16 NA NA NA hsa-miR-93-3p STAT5B -0.40282112910759 0.00131324842735598 0.206850819374263 0.00628123935114929 miRNAWalker2_validate -0.108667710764145 0.000204211018959862 NA NA NA hsa-miR-93-3p SUCLA2 -0.40282112910759 0.00131324842735598 0.54480261165811 3.83448884164253e-09 miRNAWalker2_validate -0.12347614421225 0.000708686683514907 NA NA NA hsa-miR-93-3p SYNGR1 -0.40282112910759 0.00131324842735598 0.0467874970365392 0.881901328445337 mirMAP -0.269265164383272 0.0280844977733164 NA NA NA hsa-miR-93-3p SYNPO -0.40282112910759 0.00131324842735598 0.386933601330886 0.00147471464510152 mirMAP -0.284481971034935 1.07521139287926e-09 NA NA NA hsa-miR-145-5p TBC1D16 1.47958857114771 6.4730836154326e-16 -1.09783247128336 3.62886274987029e-17 mirMAP -0.173524018120598 4.61025704137037e-07 NA NA NA hsa-miR-93-3p TBC1D2B -0.40282112910759 0.00131324842735598 0.40005905011814 0.00112893124682921 mirMAP -0.202160961611818 2.21473182827113e-05 NA NA NA hsa-miR-93-3p TEF -0.40282112910759 0.00131324842735598 -0.525410771213849 0.000338359038626352 mirMAP -0.121730651165025 0.0340817600486605 NA NA NA hsa-miR-93-3p THSD4 -0.40282112910759 0.00131324842735598 1.03249520260707 2.68769926118395e-05 MirTarget -0.339604780343891 0.000420308969962416 NA NA NA hsa-miR-93-3p TIAM1 -0.40282112910759 0.00131324842735598 1.56411477781397 6.0286681179833e-13 miRNAWalker2_validate -0.516252745636723 1.59336478577884e-09 NA NA NA hsa-miR-93-3p TK2 -0.40282112910759 0.00131324842735598 0.656683086732083 2.72821191142875e-11 mirMAP -0.248386946484398 1.01306861967756e-10 NA NA NA hsa-miR-93-3p TM2D2 -0.40282112910759 0.00131324842735598 0.658110740005189 1.44619249421986e-09 MirTarget -0.101335554539139 0.0188307142477687 NA NA NA hsa-miR-93-3p TMEM47 -0.40282112910759 0.00131324842735598 1.62158562289561 1.2627497019032e-13 MirTarget;miRNATAP -0.534990993638914 5.48604954239662e-10 NA NA NA hsa-miR-93-3p TMOD2 -0.40282112910759 0.00131324842735598 -0.273439557141348 0.0664976053061546 miRNATAP -0.315929810996551 3.26954237495657e-08 NA NA NA hsa-miR-93-3p TOM1L2 -0.40282112910759 0.00131324842735598 -0.409072452599839 6.18452585812562e-05 mirMAP -0.105552452108452 0.00825636211473601 NA NA NA hsa-miR-93-3p TOR1AIP2 -0.40282112910759 0.00131324842735598 0.337836449293361 0.0591267564574744 MirTarget -0.299202683020417 1.53719119131312e-05 NA NA NA hsa-miR-93-3p TPPP -0.40282112910759 0.00131324842735598 0.469611426280088 0.0675897589786412 mirMAP -0.435953465759037 1.14310463597684e-05 NA NA NA hsa-miR-145-5p TPR 1.47958857114771 6.4730836154326e-16 -0.602347702749361 6.08762705780914e-11 MirTarget -0.118223482098123 7.41247555205619e-07 NA NA NA hsa-miR-93-3p TSPAN18 -0.40282112910759 0.00131324842735598 -0.0414923398388818 0.79000240154948 mirMAP -0.260181850067542 1.49003551543161e-05 NA NA NA hsa-miR-93-3p UBE2D3 -0.40282112910759 0.00131324842735598 0.546454726317387 9.53324910574043e-17 MirTarget;miRNATAP -0.146156806529741 1.99180964889057e-08 NA NA NA hsa-miR-93-3p UBXN4 -0.40282112910759 0.00131324842735598 0.229924117793642 0.0102920698207314 MirTarget -0.102803358396284 0.00312855196510355 NA NA NA hsa-miR-145-5p UNC119B 1.47958857114771 6.4730836154326e-16 -1.21392832041535 7.88210718787247e-18 MirTarget -0.139980838221639 0.000197568905468616 NA NA NA hsa-miR-145-5p USP31 1.47958857114771 6.4730836154326e-16 -0.3853853894618 0.000159436643509766 MirTarget;miRNATAP -0.104143045184037 6.96150209574054e-05 NA NA NA hsa-miR-93-3p UST -0.40282112910759 0.00131324842735598 1.2216044001009 3.6877446325326e-05 MirTarget -0.517455177838149 7.28229149093867e-06 NA NA NA hsa-miR-93-3p UTP14C -0.40282112910759 0.00131324842735598 0.575445216555037 4.33492390124088e-08 miRNAWalker2_validate -0.173624260670893 2.50643754831351e-05 NA NA NA hsa-miR-145-5p UXS1 1.47958857114771 6.4730836154326e-16 -0.887384557297848 4.09760300351934e-24 miRNATAP -0.129682072826299 3.13796219786214e-08 NA NA NA hsa-miR-93-3p VGLL3 -0.40282112910759 0.00131324842735598 0.294230399406651 0.235396784808846 miRNATAP -0.308238874166218 0.00136734440188337 NA NA NA hsa-miR-145-5p VPS54 1.47958857114771 6.4730836154326e-16 -0.34928091355539 5.72682991929996e-05 MirTarget;miRNATAP -0.130123190450618 3.38745609792403e-09 NA NA NA hsa-miR-93-3p WDR45 -0.40282112910759 0.00131324842735598 -0.0846905826021329 0.306795251835328 MirTarget -0.101166514725881 0.00157979667332772 NA NA NA hsa-miR-93-3p WNK3 -0.40282112910759 0.00131324842735598 0.836532944570787 0.00785592148273514 miRNATAP -0.407385944012096 0.000888718444404638 NA NA NA hsa-miR-93-3p WWTR1 -0.40282112910759 0.00131324842735598 0.430971920019912 0.0167931197420981 MirTarget -0.183073368213084 0.00917815677234016 NA NA NA hsa-miR-145-5p ZBTB40 1.47958857114771 6.4730836154326e-16 -1.05248854418574 1.34458961008978e-27 mirMAP -0.143256143261436 4.19703951997417e-08 NA NA NA hsa-miR-145-5p ZC3H3 1.47958857114771 6.4730836154326e-16 -1.06127307078329 1.57569638197049e-20 MirTarget -0.210122970635626 2.51228172607063e-12 NA NA NA hsa-miR-93-3p ZDHHC15 -0.40282112910759 0.00131324842735598 1.05212931450714 4.19710859293853e-05 MirTarget;miRNATAP -0.234066999133796 0.0204064137630502 NA NA NA hsa-miR-145-5p ZDHHC9 1.47958857114771 6.4730836154326e-16 -0.26404710423503 0.0103896324528527 MirTarget;miRNATAP -0.109858992637807 2.92505556026386e-05 NA NA NA hsa-miR-425-3p ZNF703 0.156722391026837 0.22372009845904 -0.452841191628427 0.104223161427226 miRNAWalker2_validate -0.22932608974446 0.0309643580081956 NA NA NA hsa-miR-93-3p ZNFX1 -0.40282112910759 0.00131324842735598 0.0810183940261631 0.387805109153777 miRNAWalker2_validate -0.215649726265789 1.56419008806279e-09 NA NA NA hsa-miR-145-5p ZRANB3 1.47958857114771 6.4730836154326e-16 -0.122975016052876 0.435049944476467 MirTarget -0.100278372504392 0.0130630192379254 NA NA NA