miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-let-7b-5p	ABL1	-0.228773940533783	0.938952933213741	0.0158807082871171	0.992097260118397	miRNAWalker2_validate	-0.103500743977103	0.0037190649676014		NA	NA	NA
hsa-miR-128-3p	ABL1	-0.442192625156042	0.783886533572187	0.0158807082871171	0.992097260118397	MirTarget	-0.115184308733698	0.000418213827549692		NA	NA	NA
hsa-miR-30a-5p	ANAPC5	0.219472325612346	0.933954023293816	-0.156393707910046	0.923470786849069	miRNAWalker2_validate	-0.202139869158558	4.32073377281508e-09		NA	NA	NA
hsa-miR-324-5p	ATM	-0.50063248413014	0.537416710557032	0.191778405096067	0.864625288192543	miRanda	-0.12216548800381	0.00154765973160933		NA	NA	NA
hsa-miR-455-5p	ATM	-0.139599153671262	0.865744220236311	0.191778405096067	0.864625288192543	miRanda	-0.119520466419818	0.00128133661552861		NA	NA	NA
hsa-miR-590-5p	ATM	-0.547819833829572	0.472735645776647	0.191778405096067	0.864625288192543	mirMAP	-0.103121093611562	0.00141721793607095		NA	NA	NA
hsa-miR-139-5p	BUB1	-0.0810891026597322	0.928690377743652	-0.312631046784523	0.800804046360404	miRanda	-0.149419655380329	0.00112363111907361		NA	NA	NA
hsa-miR-199a-5p	BUB1	0.157247797504494	0.935797462797012	-0.312631046784523	0.800804046360404	miRanda	-0.222978265545006	4.99976781511025e-06		NA	NA	NA
hsa-miR-199b-5p	BUB1	-0.0396557270992508	0.977172718873203	-0.312631046784523	0.800804046360404	miRanda	-0.149557222494274	0.000501418561732459		NA	NA	NA
hsa-miR-139-5p	BUB3	-0.0810891026597322	0.928690377743652	-0.109422380413664	0.945920955070139	miRanda	-0.166339757369497	1.55090929454338e-08		NA	NA	NA
hsa-miR-130a-3p	CCNA2	0.0910074087716906	0.929098200371948	-0.311496046459293	0.814528873281056	miRNATAP	-0.170567761867125	0.00108914221992556		NA	NA	NA
hsa-miR-199a-5p	CCNA2	0.157247797504494	0.935797462797012	-0.311496046459293	0.814528873281056	miRanda	-0.266324190881128	1.44290632417647e-06		NA	NA	NA
hsa-miR-199b-5p	CCNA2	-0.0396557270992508	0.977172718873203	-0.311496046459293	0.814528873281056	miRanda	-0.157221029375264	0.00128911995270949		NA	NA	NA
hsa-miR-218-5p	CCNA2	0.233108057313884	0.810208076649842	-0.311496046459293	0.814528873281056	MirTarget	-0.289263986810766	1.78781536185659e-10		NA	NA	NA
hsa-miR-29c-3p	CCNA2	0.162451700202704	0.942720457512509	-0.311496046459293	0.814528873281056	MirTarget	-0.168242541569296	0.00117132789839678		NA	NA	NA
hsa-miR-34c-5p	CCNA2	-0.018707656771723	0.952788306178575	-0.311496046459293	0.814528873281056	miRanda	-0.248287876320509	5.48468232737822e-07		NA	NA	NA
hsa-miR-133b	CCNB1	0.392161188688359	0.560763234081075	-0.279098563483175	0.850128792274294	miRanda	-0.131334287060603	4.50924766509396e-07		NA	NA	NA
hsa-miR-139-5p	CCNB1	-0.0810891026597322	0.928690377743652	-0.279098563483175	0.850128792274294	miRanda	-0.183097769909703	0.000837427712249749		NA	NA	NA
hsa-let-7c-5p	CCNB2	-0.0629831812743404	0.974895834249241	-0.204202709262817	0.87077526103075	miRNAWalker2_validate	-0.18504849986348	3.20172665876533e-07		NA	NA	NA
hsa-miR-23b-3p	CCNB2	-0.10822254818704	0.961352920317636	-0.204202709262817	0.87077526103075	miRNAWalker2_validate	-0.330014695854348	0.000111146411555414		NA	NA	NA
hsa-miR-16-5p	CCND1	0.0135949734723564	0.994476223855607	-0.254128537418143	0.890666103231997	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.131352085119981	0.00823300401924536	23991964;22922827;18483394	At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL	;;	bladder cancer;sarcoma;lymphoma
hsa-miR-195-5p	CCND1	0.343201952346823	0.749622318650888	-0.254128537418143	0.890666103231997	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.135964440478054	0.00272099018653157	21350001;26631043;25823925	Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma	;;metastasis;poor survival	breast cancer;cervical and endocervical cancer;sarcoma
hsa-miR-29c-3p	CCND1	0.162451700202704	0.942720457512509	-0.254128537418143	0.890666103231997	mirMAP	-0.140688238276882	0.00181263740987372		NA	NA	NA
hsa-miR-125b-5p	CCNE1	0.042694645848468	0.980586836124662	-0.280205935660748	0.736508482635676	miRNAWalker2_validate	-0.153080131670566	0.000743418271995361		NA	NA	NA
hsa-miR-195-5p	CCNE1	0.343201952346823	0.749622318650888	-0.280205935660748	0.736508482635676	miRNAWalker2_validate;MirTarget;miRNATAP	-0.17512748753993	0.0030220881483402	24402230	Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively		breast cancer
hsa-miR-26a-5p	CCNE2	0.00698202897993028	0.997719986197021	-0.154004923605453	0.847304727818299	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.357013460089754	0.000842485602706472	24116110;21901171	The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression	poor survival;progression	pancreatic cancer;acute myeloid leukemia
hsa-miR-30a-5p	CCNE2	0.219472325612346	0.933954023293816	-0.154004923605453	0.847304727818299	miRNATAP	-0.438624147963128	1.0101110606114e-07		NA	NA	NA
hsa-miR-34a-5p	CCNE2	-0.50188164870224	0.742034237185732	-0.154004923605453	0.847304727818299	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.220025402098138	0.000175922127494152		NA	NA	NA
hsa-miR-34c-5p	CCNE2	-0.018707656771723	0.952788306178575	-0.154004923605453	0.847304727818299	miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP	-0.275859200004622	3.23513835152069e-07		NA	NA	NA
hsa-let-7a-3p	CDC14A	-0.215598045625677	0.85543299203799	0.0233079363277793	0.970104144635326	mirMAP	-0.151560721976898	0.00458491367698673		NA	NA	NA
hsa-miR-141-3p	CDC14A	-0.31994058840327	0.87774106909065	0.0233079363277793	0.970104144635326	TargetScan;miRNATAP	-0.125143457095599	0.00222881768605522		NA	NA	NA
hsa-miR-324-5p	CDC14A	-0.50063248413014	0.537416710557032	0.0233079363277793	0.970104144635326	miRanda	-0.134543123815743	0.00826305673573455		NA	NA	NA
hsa-miR-338-3p	CDC14A	0.49158501750012	0.788483749194189	0.0233079363277793	0.970104144635326	miRanda	-0.123736768026395	0.000534251338555472		NA	NA	NA
hsa-miR-576-5p	CDC14A	-0.506413219377403	0.417187951364173	0.0233079363277793	0.970104144635326	mirMAP	-0.133303920891091	0.0058751148333057		NA	NA	NA
hsa-miR-139-5p	CDC16	-0.0810891026597322	0.928690377743652	0.437091929813646	0.763327517028026	miRanda	-0.112455679487329	0.00565577701302578		NA	NA	NA
hsa-miR-146b-5p	CDC16	-0.402662509440887	0.837510937985091	0.437091929813646	0.763327517028026	miRanda	-0.151728226960307	0.000685057387216301		NA	NA	NA
hsa-miR-23b-3p	CDC20	-0.10822254818704	0.961352920317636	-0.25889238539639	0.85563407039011	miRNAWalker2_validate	-0.322612315799784	0.000737785099495932		NA	NA	NA
hsa-miR-30a-5p	CDC20	0.219472325612346	0.933954023293816	-0.25889238539639	0.85563407039011	miRNAWalker2_validate	-0.332970285575991	2.91489303883935e-05		NA	NA	NA
hsa-miR-125a-5p	CDC23	-0.00183986061615382	0.999158100170883	0.00294037633946687	0.998049304357663	miRanda	-0.103373588596536	0.0011708524590583		NA	NA	NA
hsa-miR-34c-5p	CDC23	-0.018707656771723	0.952788306178575	0.00294037633946687	0.998049304357663	miRanda	-0.139428621657902	4.0453185906612e-09	25064703	In addition the levels of CDC23 an important mediator in mitotic progression were suppressed following miR-34c expression and siRNAs targeting CDC23 mimicked the effect of miR-34c on G2/M arrest	progression	breast cancer
hsa-let-7c-5p	CDC25A	-0.0629831812743404	0.974895834249241	-0.284799988153742	0.784929977741311	MirTarget	-0.222448122452562	2.50285771453179e-08	25909324	MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules	progression	liver cancer
hsa-miR-195-5p	CDC25A	0.343201952346823	0.749622318650888	-0.284799988153742	0.784929977741311	MirTarget;miRNATAP	-0.194925621882831	0.00028989561187956		NA	NA	NA
hsa-miR-34c-5p	CDC25A	-0.018707656771723	0.952788306178575	-0.284799988153742	0.784929977741311	miRNATAP	-0.206316875398523	6.9901455672723e-05	21321636	Ectopic expression of miR-449b and miR-34c resulted in lowered adhesion activities by 28%-34% and in cell cycle arrests with increased cell number of 15.62% and 15.71% in G1 and with decreased cell number of 15.96% and 16.56% in S Cell cycle related proteins CDK6 and CDC25A were down-regulated; The decreases of CDK6 and CDC25A by miR-449b were 39% and 22% respecyively; 49% and 32% by miR-34c respectively		ovarian cancer
hsa-miR-497-5p	CDC25A	-0.0120217191428731	0.989147225742026	-0.284799988153742	0.784929977741311	MirTarget;miRNATAP	-0.253144560020477	6.78966466364436e-05		NA	NA	NA
hsa-miR-497-5p	CDC27	-0.0120217191428731	0.989147225742026	-0.104193221734821	0.938831007374214	miRNATAP	-0.147849328726563	7.23176443743944e-07		NA	NA	NA
hsa-miR-26a-5p	CDC6	0.00698202897993028	0.997719986197021	-0.174042607745462	0.889679752711555	miRNAWalker2_validate	-0.392194630859623	0.00053597948455827	25100863;27158389	Here it is demonstrated that miR26a and miR26b inhibit replication licensing and the proliferation migration and invasion of lung cancer cells by targeting CDC6; The current study suggests that miR26a miR26b and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets;miR 26a inhibits the proliferation of ovarian cancer cells via regulating CDC6 expression; Bioinformatics analysis revealed Cdc6 was a target gene of miR-26a; dual-luciferase assay and validation assay showed miR-26a could act on the 3'UTR of Cdc6 to regulate Cdc6 expression; These findings suggest that miR-26a may act on the 3'UTR of Cdc6 to regulate Cdc6 expression which then inhibit the proliferation of ovarian cancer cells and induce their apoptosis	;	lung cancer;ovarian cancer
hsa-miR-199a-5p	CDC7	0.157247797504494	0.935797462797012	-0.500813938225864	0.531998434396492	MirTarget;miRanda	-0.243360820953683	8.44030621797175e-05		NA	NA	NA
hsa-miR-199b-5p	CDC7	-0.0396557270992508	0.977172718873203	-0.500813938225864	0.531998434396492	MirTarget;miRanda	-0.169610167387948	0.00177768565356846		NA	NA	NA
hsa-miR-34c-5p	CDC7	-0.018707656771723	0.952788306178575	-0.500813938225864	0.531998434396492	miRanda	-0.182462738752167	0.00110829990558492		NA	NA	NA
hsa-miR-23b-3p	CDK2	-0.10822254818704	0.961352920317636	-0.00941560099946681	0.994105531325921	miRNAWalker2_validate	-0.171002677486014	0.00275427306255561		NA	NA	NA
hsa-miR-195-5p	CDK4	0.343201952346823	0.749622318650888	-0.0555656491892718	0.974291102166537	miRNAWalker2_validate;miRTarBase	-0.178739487005888	1.99144590740755e-06		NA	NA	NA
hsa-miR-34c-5p	CDK4	-0.018707656771723	0.952788306178575	-0.0555656491892718	0.974291102166537	miRNAWalker2_validate;miRTarBase	-0.109354693621618	0.0030808277323941		NA	NA	NA
hsa-miR-21-5p	CDK6	-0.148920887107433	0.970240620972126	0.263751741096359	0.851495006493897	miRNAWalker2_validate;mirMAP	-0.322969883377914	4.63783733839343e-05		NA	NA	NA
hsa-miR-22-3p	CDK6	0.0592693913158495	0.986564295498741	0.263751741096359	0.851495006493897	miRNAWalker2_validate	-0.265335616194499	0.00120632355440899		NA	NA	NA
hsa-miR-139-5p	CDK7	-0.0810891026597322	0.928690377743652	-0.0694038687744483	0.950858577449365	miRanda	-0.153702484145495	0.000108810457856673		NA	NA	NA
hsa-let-7c-5p	CDKN1A	-0.0629831812743404	0.974895834249241	0.0967867865725873	0.953141906484364	MirTarget	-0.152073389305065	0.0033021603310084		NA	NA	NA
hsa-miR-101-3p	CDKN1A	0.0107754887734437	0.997036362636866	0.0967867865725873	0.953141906484364	MirTarget	-0.403803292172332	3.96045856328491e-05		NA	NA	NA
hsa-miR-708-5p	CDKN1A	-0.0282907993048824	0.974929832201158	0.0967867865725873	0.953141906484364	MirTarget	-0.137894178596668	0.00964228236869156		NA	NA	NA
hsa-miR-139-5p	CDKN1B	-0.0810891026597322	0.928690377743652	-0.152387559025753	0.919619146249378	miRanda	-0.128190087040829	0.00102726290927428		NA	NA	NA
hsa-miR-342-3p	CDKN1B	-0.371626144515113	0.77313668985267	-0.152387559025753	0.919619146249378	miRanda	-0.122445542838444	0.00143327458289343		NA	NA	NA
hsa-miR-582-3p	CDKN1B	-0.2334649592375	0.897678119160318	-0.152387559025753	0.919619146249378	PITA	-0.108548795204556	0.00639102913863969		NA	NA	NA
hsa-miR-107	CDKN1C	-0.0365118169251648	0.988364120226869	0.615008499158186	0.389426393297138	miRanda	-0.482882195423853	0.000876360917951107		NA	NA	NA
hsa-miR-25-3p	CDKN1C	-0.457540448732733	0.878574066837636	0.615008499158186	0.389426393297138	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.484592372031889	5.77646558804015e-05		NA	NA	NA
hsa-miR-335-5p	CDKN1C	-0.0284895175847679	0.973380867832231	0.615008499158186	0.389426393297138	miRNAWalker2_validate	-0.206780758085497	0.00910627585073384		NA	NA	NA
hsa-miR-429	CDKN1C	-0.456485631615963	0.806240953400535	0.615008499158186	0.389426393297138	miRNATAP	-0.23236392726296	0.00063901302897805		NA	NA	NA
hsa-miR-590-3p	CDKN1C	-0.279244755376859	0.59126669933662	0.615008499158186	0.389426393297138	miRanda	-0.328121688842812	3.88720635545832e-06		NA	NA	NA
hsa-miR-92a-3p	CDKN1C	0.0278830870766349	0.993247426671713	0.615008499158186	0.389426393297138	MirTarget;miRNATAP	-0.241818245896803	0.00659681800999508		NA	NA	NA
hsa-let-7g-5p	CDKN2A	-0.200947212961157	0.922992045181955	1.38311764888886	0.0180278819048057	miRNAWalker2_validate;miRTarBase	-0.535554308915819	0.00297017801707372		NA	NA	NA
hsa-miR-19a-3p	CDKN2B	-0.206793507801887	0.844637784802316	0.615709536731054	0.50940135954576	mirMAP	-0.413439175975935	2.07686969241033e-08		NA	NA	NA
hsa-miR-19b-3p	CDKN2B	-0.0268530183621474	0.986656783046572	0.615709536731054	0.50940135954576	mirMAP	-0.563119310667794	1.07291685469738e-10		NA	NA	NA
hsa-miR-335-3p	CDKN2B	-0.244830745789445	0.88450019116631	0.615709536731054	0.50940135954576	mirMAP	-0.495467696918815	6.74998490105792e-10		NA	NA	NA
hsa-miR-374b-5p	CDKN2B	-0.285682091626878	0.83569830479965	0.615709536731054	0.50940135954576	miRNAWalker2_validate	-0.569055517409637	4.8179561491835e-06		NA	NA	NA
hsa-miR-429	CDKN2B	-0.456485631615963	0.806240953400535	0.615709536731054	0.50940135954576	miRanda	-0.342327706112616	1.29415923787771e-06		NA	NA	NA
hsa-miR-450b-5p	CDKN2B	-0.0136687538973108	0.983149761399849	0.615709536731054	0.50940135954576	mirMAP	-0.289155171370823	0.00227044413589696		NA	NA	NA
hsa-miR-501-3p	CDKN2B	-0.753812576327832	0.552763280802254	0.615709536731054	0.50940135954576	PITA	-0.291581269663195	0.000514618770289606		NA	NA	NA
hsa-miR-501-5p	CDKN2B	-0.834032628506285	0.0582725160418523	0.615709536731054	0.50940135954576	mirMAP	-0.190045384751774	0.00497127071527415		NA	NA	NA
hsa-miR-502-3p	CDKN2B	-0.481234445251923	0.514301076452422	0.615709536731054	0.50940135954576	PITA	-0.352662677872443	0.000350724670735813		NA	NA	NA
hsa-miR-576-5p	CDKN2B	-0.506413219377403	0.417187951364173	0.615709536731054	0.50940135954576	MirTarget	-0.371727453666953	3.81871611467468e-05		NA	NA	NA
hsa-miR-671-5p	CDKN2B	-0.373754118103105	0.411207779636977	0.615709536731054	0.50940135954576	PITA	-0.267468979503672	0.00458506983043419		NA	NA	NA
hsa-miR-7-1-3p	CDKN2B	-0.462485777435991	0.665899751398166	0.615709536731054	0.50940135954576	MirTarget	-0.324151269014201	0.00024857957298821		NA	NA	NA
hsa-miR-98-5p	CDKN2B	-0.168162186023221	0.898802461503524	0.615709536731054	0.50940135954576	miRNAWalker2_validate	-0.375199473130553	0.00233908895657839		NA	NA	NA
hsa-miR-139-5p	CHEK1	-0.0810891026597322	0.928690377743652	-0.282075347316236	0.78553656972735	miRanda	-0.13247727540385	0.00213446723619324		NA	NA	NA
hsa-miR-195-5p	CHEK1	0.343201952346823	0.749622318650888	-0.282075347316236	0.78553656972735	MirTarget;miRNATAP	-0.157301144457684	0.000252651965237698	25840419	MiR 195 suppresses non small cell lung cancer by targeting CHEK1; We discovered that CHEK1 was a direct target of miR-195 which decreased CHEK1 expression in lung cancer cells		lung squamous cell cancer
hsa-miR-497-5p	CHEK1	-0.0120217191428731	0.989147225742026	-0.282075347316236	0.78553656972735	MirTarget;miRNATAP	-0.205994264459408	4.95603777290773e-05	24464213	Checkpoint kinase 1 is negatively regulated by miR 497 in hepatocellular carcinoma; In silico analysis showed that CHEK1 was a candidate target of miR-497 which was previously found to be downregulated in HCC by us; To test whether miR-497 could bind to 3'untranslated region 3'UTR of CHEK1 luciferase reporter assay was conducted; The result revealed that miR-497 could bind to the 3'untranslated region 3'UTR of CHEK1 mRNA; Western blot showed that ectopic expression of miR-497 suppressed the CHEK1 expression and inhibition of miR-497 led to significant upregulation of CHEK1; Finally miR-497 expression was measured in the same 30 HCC samples and the correlation between miR-497 and CHEK1 was analyzed; The results indicated that miR-497 was downregulated in HCC and had a significant negative correlation with CHEK1; Taken together these results demonstrated that CHEK1 was negatively regulated by miR-497 and the overexpressed CHEK1 was resulted from the downregulated miR-497 in HCC which provided a potential molecular target for HCC therapy		liver cancer
hsa-miR-493-5p	CREBBP	0.229930075372342	0.731979520100109	-0.0709718431637629	0.963143997108611	miRNATAP	-0.131589658655616	0.000363570308901921		NA	NA	NA
hsa-miR-199a-5p	DBF4	0.157247797504494	0.935797462797012	-0.131004881099642	0.901603007511309	miRanda	-0.173096961328523	0.000121605146859541		NA	NA	NA
hsa-miR-30a-5p	DBF4	0.219472325612346	0.933954023293816	-0.131004881099642	0.901603007511309	MirTarget	-0.223669607239314	0.000312620478594278		NA	NA	NA
hsa-miR-23b-3p	E2F1	-0.10822254818704	0.961352920317636	-0.0851453844258039	0.941136142122081	miRNAWalker2_validate	-0.279821230884123	0.00275454005531901		NA	NA	NA
hsa-let-7c-5p	E2F2	-0.0629831812743404	0.974895834249241	-0.407084382308647	0.65831673411391	MirTarget	-0.267016294713361	1.65643202644507e-08		NA	NA	NA
hsa-miR-125b-5p	E2F2	0.042694645848468	0.980586836124662	-0.407084382308647	0.65831673411391	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.235790107017282	1.22460526383478e-06	22999819	miR 125b regulates the proliferation of glioblastoma stem cells by targeting E2F2; This study demonstrated that miR-125b plays important roles in regulating the proliferation of GSCs by directly targeting E2F2		glioblastoma
hsa-miR-30c-2-3p	E2F2	0.242912714924037	0.746927269997556	-0.407084382308647	0.65831673411391	MirTarget	-0.284824076032081	0.000185227460467619		NA	NA	NA
hsa-miR-365a-3p	E2F2	0.0797451871548276	0.938758494058574	-0.407084382308647	0.65831673411391	MirTarget	-0.256321543493715	0.000968411292124288		NA	NA	NA
hsa-let-7b-5p	E2F3	-0.228773940533783	0.938952933213741	0.0461599707693674	0.968370289084558	miRNAWalker2_validate	-0.115378088824355	0.00569833983741018		NA	NA	NA
hsa-miR-92b-3p	E2F3	-0.569866984318692	0.689321861489779	0.0461599707693674	0.968370289084558	miRNATAP	-0.104545956087163	0.000231648986894289		NA	NA	NA
hsa-miR-23b-3p	E2F4	-0.10822254818704	0.961352920317636	0.0782145176737483	0.959517725508382	miRNAWalker2_validate	-0.168171413412203	0.000923959853055173		NA	NA	NA
hsa-let-7e-5p	E2F5	0.211156073215582	0.922335699862928	-0.157383291242298	0.864493855870243	MirTarget;miRNATAP	-0.271432560208732	0.00166942126600265		NA	NA	NA
hsa-miR-1271-5p	E2F5	-0.464440824492835	0.095633275297856	-0.157383291242298	0.864493855870243	MirTarget	-0.149836841087909	0.00563329787990665		NA	NA	NA
hsa-miR-132-3p	E2F5	-0.244143673573889	0.871752726220643	-0.157383291242298	0.864493855870243	MirTarget	-0.244768709787888	0.00572664740993965	27186275	miR 132 targeting E2F5 suppresses cell proliferation invasion migration in ovarian cancer cells; Mechanism investigation revealed that miR-132 inhibited the expression of transcription factor E2F5 by specifically targeting its mRNA 3'UTR; Moreover the expression level of E2F5 was significantly increased in ovarian cancer tissues than in the adjacent normal tissues and its expression was inversely correlated with miR-132 expression in clinical ovarian cancer tissues; Additionally silencing E2F5 was able to inhibit the proliferation colony formation migration and invasion of ovarian cancer cells parallel to the effect of miR-132 overexpression on the ovarian cancer cells; Meanwhile overexpression of E2F5 reversed the inhibition effect mediated by miR-132 overexpression; These results indicate that miR-132 suppresses the cell proliferation invasion migration in ovarian cancer cells by targeting E2F5		ovarian cancer
hsa-miR-142-3p	E2F5	-0.154235241441331	0.946098054588918	-0.157383291242298	0.864493855870243	miRanda	-0.171797963730066	0.00024380269614169		NA	NA	NA
hsa-miR-320b	E2F5	-0.23561798088153	0.859222532827992	-0.157383291242298	0.864493855870243	miRanda	-0.206365770697953	0.000783371416692188		NA	NA	NA
hsa-miR-34a-5p	E2F5	-0.50188164870224	0.742034237185732	-0.157383291242298	0.864493855870243	miRNAWalker2_validate;MirTarget;miRNATAP	-0.242296158889742	7.29030262672331e-05	26103003	MicroRNA 34a targets FMNL2 and E2F5 and suppresses the progression of colorectal cancer; FMNL2 and E2F5 were identified as direct targets of miR-34a; Reintroduction of FMNL2 or E2F5 without 3'UTR region reversed the inhibitory effects of miR-34a on cell proliferation and invasion; MiR-34a was down-regulated in CRC cells and inversely correlated with FMNL2 and E2F5 expressions; Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5 thus providing new insight into the molecular mechanisms underlying CRC progression and establishing a strong potential for the application of miR-34a as a novel therapeutic marker against CRC	progression	colorectal cancer
hsa-miR-34c-5p	E2F5	-0.018707656771723	0.952788306178575	-0.157383291242298	0.864493855870243	MirTarget;PITA;miRanda;miRNATAP	-0.150704375218674	0.00885721830953835		NA	NA	NA
hsa-miR-106b-5p	EP300	-0.297128724729339	0.869294443540749	-0.275785871935125	0.858275138267876	miRNATAP	-0.130709049655062	0.000960073772533261		NA	NA	NA
hsa-miR-26b-5p	EP300	-0.0245931278499594	0.990377966314923	-0.275785871935125	0.858275138267876	miRNAWalker2_validate;miRNATAP	-0.122462053179979	0.0081599533716202		NA	NA	NA
hsa-miR-339-5p	EP300	-0.300425087100667	0.712912847076788	-0.275785871935125	0.858275138267876	miRanda	-0.107604978422911	0.000130192205849388		NA	NA	NA
hsa-miR-369-3p	EP300	0.116576891957687	0.83230082995912	-0.275785871935125	0.858275138267876	MirTarget;PITA;miRNATAP	-0.151763068163101	1.43595410012867e-05		NA	NA	NA
hsa-let-7c-5p	ESPL1	-0.0629831812743404	0.974895834249241	-0.28042144678384	0.800650633724193	MirTarget	-0.161163278102272	1.60555678204786e-05		NA	NA	NA
hsa-miR-324-3p	GADD45B	-0.424387380347173	0.661528309116338	0.524578686880012	0.613526698742649	MirTarget;miRNATAP	-0.215175591383005	0.00285407658213762		NA	NA	NA
hsa-miR-590-3p	GADD45B	-0.279244755376859	0.59126669933662	0.524578686880012	0.613526698742649	miRanda	-0.228270935470796	2.64404491951025e-06		NA	NA	NA
hsa-miR-132-3p	GSK3B	-0.244143673573889	0.871752726220643	-0.0279273799391531	0.984168396316634	mirMAP;miRNATAP	-0.110221716663843	0.000912142142693881		NA	NA	NA
hsa-miR-146b-3p	GSK3B	-0.408862981477661	0.762520540478861	-0.0279273799391531	0.984168396316634	miRNATAP	-0.124674628963768	4.92920707796624e-08		NA	NA	NA
hsa-miR-146b-5p	GSK3B	-0.402662509440887	0.837510937985091	-0.0279273799391531	0.984168396316634	miRanda	-0.144433253868449	1.55437010316677e-09		NA	NA	NA
hsa-miR-155-5p	GSK3B	-0.407235807706004	0.828669616718496	-0.0279273799391531	0.984168396316634	miRNAWalker2_validate;miRNATAP	-0.101330604682835	1.443796438774e-06		NA	NA	NA
hsa-miR-212-3p	GSK3B	-0.0224067199236484	0.973232008101458	-0.0279273799391531	0.984168396316634	mirMAP;miRNATAP	-0.114396409575091	1.59972400030542e-05		NA	NA	NA
hsa-miR-30a-5p	HDAC1	0.219472325612346	0.933954023293816	-0.198776998046144	0.914273392133903	miRNAWalker2_validate	-0.218523563772463	8.53938199427555e-06		NA	NA	NA
hsa-miR-34c-5p	HDAC1	-0.018707656771723	0.952788306178575	-0.198776998046144	0.914273392133903	miRanda;miRNATAP	-0.139666200321477	1.38183526497912e-05		NA	NA	NA
hsa-miR-132-3p	HDAC2	-0.244143673573889	0.871752726220643	-0.0946288386348746	0.954183878424831	mirMAP	-0.171255324077529	0.000359819454736748		NA	NA	NA
hsa-miR-155-5p	HDAC2	-0.407235807706004	0.828669616718496	-0.0946288386348746	0.954183878424831	mirMAP	-0.109762222433032	0.000364165078781078	21946536	Mechanistically we found that BRCA1 epigenetically represses miR-155 expression via its association with HDAC2 which deacetylates histones H2A and H3 on the miR-155 promoter		breast cancer
hsa-miR-92b-3p	HDAC2	-0.569866984318692	0.689321861489779	-0.0946288386348746	0.954183878424831	mirMAP	-0.110474346001598	0.000227939512369046		NA	NA	NA
hsa-miR-133b	MAD2L1	0.392161188688359	0.560763234081075	-0.3197651045519	0.802438827385151	miRanda	-0.12265295195834	5.56759601974164e-07		NA	NA	NA
hsa-miR-139-5p	MAD2L1	-0.0810891026597322	0.928690377743652	-0.3197651045519	0.802438827385151	miRanda	-0.201153458982366	8.92582052788916e-05		NA	NA	NA
hsa-miR-139-5p	MCM2	-0.0810891026597322	0.928690377743652	-0.255685794568882	0.86599434971323	miRanda	-0.138768973681921	0.00136280920783438		NA	NA	NA
hsa-miR-34c-5p	MCM2	-0.018707656771723	0.952788306178575	-0.255685794568882	0.86599434971323	miRanda	-0.127214535496063	0.00246297411668181		NA	NA	NA
hsa-miR-23b-3p	MCM4	-0.10822254818704	0.961352920317636	-0.381720125974931	0.81150019678017	MirTarget	-0.303545273565781	0.00060732685581776		NA	NA	NA
hsa-miR-34a-5p	MCM4	-0.50188164870224	0.742034237185732	-0.381720125974931	0.81150019678017	miRNAWalker2_validate	-0.18722539240547	0.000316535391164078		NA	NA	NA
hsa-miR-30c-2-3p	MCM6	0.242912714924037	0.746927269997556	-0.354194615638424	0.808315062359044	MirTarget	-0.187359739660106	5.41172663705239e-05		NA	NA	NA
hsa-miR-143-3p	MDM2	0.371591944134735	0.927341352649583	-0.485742577574077	0.723491564717608	miRNAWalker2_validate	-0.16317524344501	0.00124362026384159		NA	NA	NA
hsa-miR-320b	MYC	-0.23561798088153	0.859222532827992	-0.445372871610816	0.811492365164222	miRNAWalker2_validate	-0.243607030835589	0.000321638494084035	26487644	miR 320b suppresses cell proliferation by targeting c Myc in human colorectal cancer cells; Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo while c-MYC was identified as a target gene of miR-320b in CRC; Furthermore it was found that up-regulation of c-Myc can attenuate the effects induced by miR-320b; Our identification of c-MYC as a target gene of miR-320b provides new insights into the pathophysiology of CRC proliferation and identifies miR-320b as a novel therapeutic target for the treatment of CRC		colorectal cancer
hsa-miR-217	PCNA	0.341080669095094	0.760998144794468	-0.316732469854374	0.853291996661393	miRanda;miRNATAP	-0.107170065168399	0.00291630011892968	25653720	In vitro treatment with miR-217 mimics significantly suppressed the proliferation of MCF-7 cells induced G1 phase arrest and inhibited the expression of cyclin D1; while these effects were significantly reversed by the restoration of DACH1; In MDA-MB-231 cells treatment with miR-217 inhibitors enhanced the cellular proliferation promoted cell cycle progression and upregulated the expression of cyclin D1 which were neutralized by the pre-treatment of siRNA-DACH1; In vivo inhibition of miR-217 significantly suppressed the xenografts growth and downregulated the expression of cyclin D1	progression	breast cancer
hsa-miR-30a-5p	PCNA	0.219472325612346	0.933954023293816	-0.316732469854374	0.853291996661393	miRNAWalker2_validate	-0.327847270784676	6.09402828344295e-06		NA	NA	NA
hsa-miR-100-5p	PLK1	0.0230258429671419	0.992818348620337	-0.191621931033225	0.890350191888163	miRNAWalker2_validate;miRTarBase	-0.199776940560773	1.06094561389214e-08	23151088;22246341;23842624;25537513;22120675;21636267	MicroRNA 100 is a potential molecular marker of non small cell lung cancer and functions as a tumor suppressor by targeting polo like kinase 1; By using microRNA miR target prediction algorithms we identified miR-100 that might potentially bind the 3'-untranslated region of PLK1 transcripts; The purpose of this study was to investigate the roles of miR-100 and its association with PLK1 in NSCLC development; Finally the effects of miR-100 expression on growth apoptosis and cell cycle of NSCLC cells by posttranscriptionally regulating PLK1 expression were determined; Meanwhile miR-100 mimics could significantly inhibit PLK1 mRNA and protein expression and reduce the luciferase activity of a PLK1 3' untranslated region-based reporter construct in A549 cells; Furthermore small interfering RNA siRNA-mediated PLK1 downregulation could mimic the effects of miR-100 mimics while PLK1 overexpression could partially rescue the phenotypical changes of NSCLC cells induced by miR-100 mimics; Our findings indicate that low miR-100 may be a poor prognostic factor for NSCLC patients and functions as a tumor suppressor by posttranscriptionally regulating PLK1 expression;Together these results suggest that low miR-100 expression may be an independent poor prognostic factor and miR-100 can function as a tumor suppressor by targeting PLK1 in human EOCs;In HCC tissues miR-100 expression was inversely correlated with the expression of plk1 protein r = -0.418; P = 0.029; Therefore downregulation of miR-100 was correlated with progressive pathological feature and poor prognosis in HCC patients and miR-100 could function as a tumor suppressor by targeting plk1;Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 Plk1 down-regulation;MiR 100 resensitizes docetaxel resistant human lung adenocarcinoma cells SPC A1 to docetaxel by targeting Plk1; Knock-down of Plk1 which was a direct target of miR-100 yielded similar effects as that of ectopic miR-100 expression; The inverse correlation between miR-100 and Plk1 expression was also detected in nude mice SPC-A1/DTX tumor xenografts and clinical lung adenocarcinoma tissues and was proved to be related with the in vivo response to docetaxel; Thus our results suggested that down-regulation of miR-100 could lead to Plk1 over-expression and eventually to docetaxel chemoresistance of human lung adenocarcinoma;Reduced miR 100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein; Through modulating miR-100 expression using miR-100 inhibitor or mimic in vitro cell growth cycle and apoptosis were tested separately by MTT or flow cytometry and meanwhile Polo-like kinase1 PLK1 mRNA and protein expressions were detected by qRT-PCR and immunoblotting; The expression of PLK1 in 125 cervical tissues was also examined by immunohistochemical staining and the correlation between miR-100 and PLK1 expression in the same tissues was analysed; The modulation of miR-100 expression remarkably influenced cell proliferation cycle and apoptosis as well as the level of PLK1 protein but not mRNA in vitro experiments; PLK1 expression was negatively correlated with miR-100 expression in CIN3 and cervical cancer tissues; The reduced miR-100 expression participates in the development of cervical cancer at least partly through loss of inhibition to target gene PLK1 which probably occurs in a relative late phase of carcinogenesis	;;progression;worse prognosis;;drug resistance;tumorigenesis	lung squamous cell cancer;ovarian cancer;liver cancer;breast cancer;lung cancer;cervical and endocervical cancer
hsa-let-7b-3p	RAD21	-0.286212135502696	0.812160509578046	-0.0128121574752367	0.994507937216366	miRNATAP	-0.134601765064404	0.00477991843886365		NA	NA	NA
hsa-miR-126-5p	RAD21	0.0815213541035824	0.956637332055185	-0.0128121574752367	0.994507937216366	mirMAP	-0.129901066377247	0.00331417731845178		NA	NA	NA
hsa-miR-139-5p	RAD21	-0.0810891026597322	0.928690377743652	-0.0128121574752367	0.994507937216366	miRanda	-0.10768011248092	0.00235181592721979		NA	NA	NA
hsa-miR-142-5p	RAD21	-0.118920788314118	0.929665277963083	-0.0128121574752367	0.994507937216366	PITA	-0.105637226150747	0.000618333145740294		NA	NA	NA
hsa-miR-195-3p	RAD21	0.122473158217745	0.691917127032363	-0.0128121574752367	0.994507937216366	MirTarget;miRNATAP	-0.105280468035585	0.000798200118599613		NA	NA	NA
hsa-miR-199a-5p	RAD21	0.157247797504494	0.935797462797012	-0.0128121574752367	0.994507937216366	miRanda	-0.152355375838207	5.66190072518288e-05		NA	NA	NA
hsa-miR-199b-5p	RAD21	-0.0396557270992508	0.977172718873203	-0.0128121574752367	0.994507937216366	miRanda	-0.124068260231913	0.000173488540574779		NA	NA	NA
hsa-miR-299-5p	RAD21	-0.320370661718649	0.435352070725171	-0.0128121574752367	0.994507937216366	MirTarget;PITA;miRNATAP	-0.13271369795021	2.51702255214787e-05		NA	NA	NA
hsa-miR-320a	RAD21	-0.416546433767628	0.840202138616422	-0.0128121574752367	0.994507937216366	MirTarget;PITA;miRanda;miRNATAP	-0.118897863685584	0.00372252038289061		NA	NA	NA
hsa-miR-320b	RAD21	-0.23561798088153	0.859222532827992	-0.0128121574752367	0.994507937216366	MirTarget;PITA;miRanda;miRNATAP	-0.120144032688151	0.00106441330595646		NA	NA	NA
hsa-miR-433-3p	RAD21	-0.0334146718980423	0.905273137999843	-0.0128121574752367	0.994507937216366	MirTarget	-0.103805300977959	0.00136063112285217		NA	NA	NA
hsa-miR-493-5p	RAD21	0.229930075372342	0.731979520100109	-0.0128121574752367	0.994507937216366	miRNATAP	-0.137500652116927	0.00113467057879011		NA	NA	NA
hsa-miR-126-5p	RBL2	0.0815213541035824	0.956637332055185	-0.0691935411360998	0.961846430981863	MirTarget	-0.103091093417419	0.00636693014727537		NA	NA	NA
hsa-miR-1287-5p	RBL2	-0.39196072316876	0.643886814937723	-0.0691935411360998	0.961846430981863	MirTarget	-0.109189265531776	0.00463215553698131		NA	NA	NA
hsa-miR-130a-3p	SKP1	0.0910074087716906	0.929098200371948	0.0785624221664962	0.964224893360423	MirTarget	-0.108880313437338	0.000189665521401675		NA	NA	NA
hsa-miR-152-3p	SKP1	0.203532896690202	0.90975730233375	0.0785624221664962	0.964224893360423	MirTarget	-0.149618810294814	0.00237149821646277		NA	NA	NA
hsa-miR-26a-5p	SKP2	0.00698202897993028	0.997719986197021	-0.320524862899464	0.726959009655121	MirTarget	-0.354542846504322	6.889594133759e-05		NA	NA	NA
hsa-miR-30a-5p	SKP2	0.219472325612346	0.933954023293816	-0.320524862899464	0.726959009655121	MirTarget;miRNATAP	-0.340592615734323	8.91222474891312e-07		NA	NA	NA
hsa-miR-30b-5p	SKP2	-0.0121430518253582	0.994622896704513	-0.320524862899464	0.726959009655121	MirTarget;miRNATAP	-0.117474084147428	0.00985457997830105		NA	NA	NA
hsa-miR-224-5p	SMAD2	-0.240425158977724	0.857351098476517	-0.341385137878995	0.80352777577035	mirMAP	-0.144946896100267	2.28330730309658e-06		NA	NA	NA
hsa-miR-335-3p	SMAD2	-0.244830745789445	0.88450019116631	-0.341385137878995	0.80352777577035	mirMAP	-0.183748416593897	1.45959723247652e-06		NA	NA	NA
hsa-miR-361-5p	SMAD2	-0.138735309928775	0.941495130308343	-0.341385137878995	0.80352777577035	MirTarget	-0.259356843450004	0.000295254093149791		NA	NA	NA
hsa-miR-362-5p	SMAD2	-0.26647467080141	0.752024885130738	-0.341385137878995	0.80352777577035	mirMAP	-0.136859171316736	2.57672906518625e-05		NA	NA	NA
hsa-miR-374a-5p	SMAD2	-0.343007247142618	0.766921280269271	-0.341385137878995	0.80352777577035	MirTarget	-0.253649660447609	2.52056689655766e-05		NA	NA	NA
hsa-miR-374b-5p	SMAD2	-0.285682091626878	0.83569830479965	-0.341385137878995	0.80352777577035	MirTarget	-0.229429865423688	8.85252457736708e-05		NA	NA	NA
hsa-miR-421	SMAD2	-0.182032017078616	0.734704500318599	-0.341385137878995	0.80352777577035	miRanda	-0.145020546518494	0.000344143197074529		NA	NA	NA
hsa-miR-532-5p	SMAD2	-0.349665553500088	0.878948352437467	-0.341385137878995	0.80352777577035	MirTarget	-0.161763384526726	0.000125286468937968		NA	NA	NA
hsa-miR-106a-5p	SMAD4	-0.203919267842652	0.802213958426804	-0.473107439957935	0.714784528258547	mirMAP;miRNATAP	-0.131559182838557	0.00285404554218347		NA	NA	NA
hsa-miR-126-5p	SMAD4	0.0815213541035824	0.956637332055185	-0.473107439957935	0.714784528258547	mirMAP	-0.17020815706545	0.00292610435147629		NA	NA	NA
hsa-miR-130a-3p	SMAD4	0.0910074087716906	0.929098200371948	-0.473107439957935	0.714784528258547	miRNAWalker2_validate;miRNATAP	-0.184401339431379	5.24541105443445e-05		NA	NA	NA
hsa-miR-17-5p	SMAD4	-0.175448849583061	0.934544015912731	-0.473107439957935	0.714784528258547	miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP	-0.156039110852489	5.25398949950574e-05		NA	NA	NA
hsa-miR-188-5p	SMAD4	-0.568517670542551	0.324820848307954	-0.473107439957935	0.714784528258547	mirMAP	-0.155102827964383	1.62558980704385e-06		NA	NA	NA
hsa-miR-18a-5p	SMAD4	-0.498318455303917	0.61264091975585	-0.473107439957935	0.714784528258547	miRNAWalker2_validate	-0.114726944873734	0.000401136839426702		NA	NA	NA
hsa-miR-19a-3p	SMAD4	-0.206793507801887	0.844637784802316	-0.473107439957935	0.714784528258547	miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP	-0.128678500941526	0.000480832222870715		NA	NA	NA
hsa-miR-19b-1-5p	SMAD4	-0.0105982583216702	0.988511655226679	-0.473107439957935	0.714784528258547	mirMAP	-0.114973355211667	0.00512532740693421		NA	NA	NA
hsa-miR-19b-3p	SMAD4	-0.0268530183621474	0.986656783046572	-0.473107439957935	0.714784528258547	miRNAWalker2_validate;mirMAP;miRNATAP	-0.168993961293221	0.000120795994186259		NA	NA	NA
hsa-miR-20a-3p	SMAD4	0.456808229166028	0.57674056136504	-0.473107439957935	0.714784528258547	mirMAP	-0.10577777067313	0.000632028096974473	27286257	MicroRNA 20a 5p promotes colorectal cancer invasion and metastasis by downregulating Smad4	metastasis	colorectal cancer
hsa-miR-20a-5p	SMAD4	-0.179153323927949	0.928118119139752	-0.473107439957935	0.714784528258547	miRNAWalker2_validate;mirMAP;miRNATAP	-0.135068597650963	0.000403680215106847	27286257	MicroRNA 20a 5p promotes colorectal cancer invasion and metastasis by downregulating Smad4; miR-20a-5p negatively regulated Smad4 by directly targeting its 3'UTR in human colorectal cancer cells; miR-20a-5p not only promoted CRC cells aggression capacity in vitro and liver metastasis in vivo but also promoted the epithelial-to-mesenchymal transition process by downregulating Smad4 expression; Luciferase reporter assay and transfection technique were used to validate the correlation between miR-20a-5p and Smad4 in CRC; Wound healing transwell and tumorigenesis assays were used to explore the function of miR-20a-5p and Smad4 in CRC progression in vitro and in vivo; miR-20a-5p as an onco-miRNA promoted the invasion and metastasis ability by suppressing Smad4 expression in CRC cells and high miR-20a-5p predicted poor prognosis for CRC patients providing a novel and promising therapeutic target in human colorectal cancer	metastasis;progression;tumorigenesis;worse prognosis	colorectal cancer
hsa-miR-214-5p	SMAD4	0.056229650193357	0.945594330093021	-0.473107439957935	0.714784528258547	MirTarget	-0.147056148842957	0.000874920355644155		NA	NA	NA
hsa-miR-224-3p	SMAD4	0.110372723153393	0.749091467231007	-0.473107439957935	0.714784528258547	mirMAP	-0.15203159741221	1.47510559860259e-05	24817781;24152489;26187928;23913306;25804630;26307684	Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels and inhibited the formation of actin filaments;In addition the regulation of SMAD4 by miR-224 was evaluated by qRT-PCR Western blotting and luciferase reporter assays; Furthermore the over-expression of miR-224 in CRC cell lines decreased SMAD4 expression at the translational level and decreased SMAD4-driven luciferase-reporter activity;Increased miR-224 expression promotes cell migration invasion and proliferation by directly targeting the tumor suppressors TNFα-induced protein 1 TNFAIP1 and SMAD4; Up-regulated miR-224 thus facilitates tumor progression by shifting the equilibrium of the partially antagonist functions of SMAD4 and TNFAIP1 toward enhanced invasion and growth in NSCLC;Our in vitro study demonstrated that miR-224 played an oncogenic role in hepatoma cell migration and tumor formation through silencing its target gene Smad4; A noncanonical pathway links autophagy miR-224 Smad4 and HBV-associated HCC;We identified SMAD4 as a miR-224 target and observed negative correlation Spearman Rs=-0.44 p<0.0001 between SMAD4 and miR-224 expression in clinical samples; In the TCGA set combined analysis of miR-224 with SMAD4 expression enhanced correlation with survival HR 4.12 95% CI 1.1 to 15.41 p=0.0175; MiR-224 promotes CRC metastasis at least in part through the regulation of SMAD4;We further demonstrated that miR-224 functions as an oncogene in NSCLC by directly targeting TNFAIP1 and SMAD4	;;cell migration;progression;cell migration;poor survival;metastasis;	colorectal cancer;colorectal cancer;lung squamous cell cancer;liver cancer;colorectal cancer;lung cancer
hsa-miR-224-5p	SMAD4	-0.240425158977724	0.857351098476517	-0.473107439957935	0.714784528258547	miRNAWalker2_validate;miRTarBase;MirTarget	-0.161750410504916	4.20843705349202e-07	24817781;24152489;26187928;23913306;25804630;26307684	Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels and inhibited the formation of actin filaments;In addition the regulation of SMAD4 by miR-224 was evaluated by qRT-PCR Western blotting and luciferase reporter assays; Furthermore the over-expression of miR-224 in CRC cell lines decreased SMAD4 expression at the translational level and decreased SMAD4-driven luciferase-reporter activity;Increased miR-224 expression promotes cell migration invasion and proliferation by directly targeting the tumor suppressors TNFα-induced protein 1 TNFAIP1 and SMAD4; Up-regulated miR-224 thus facilitates tumor progression by shifting the equilibrium of the partially antagonist functions of SMAD4 and TNFAIP1 toward enhanced invasion and growth in NSCLC;Our in vitro study demonstrated that miR-224 played an oncogenic role in hepatoma cell migration and tumor formation through silencing its target gene Smad4; A noncanonical pathway links autophagy miR-224 Smad4 and HBV-associated HCC;We identified SMAD4 as a miR-224 target and observed negative correlation Spearman Rs=-0.44 p<0.0001 between SMAD4 and miR-224 expression in clinical samples; In the TCGA set combined analysis of miR-224 with SMAD4 expression enhanced correlation with survival HR 4.12 95% CI 1.1 to 15.41 p=0.0175; MiR-224 promotes CRC metastasis at least in part through the regulation of SMAD4;We further demonstrated that miR-224 functions as an oncogene in NSCLC by directly targeting TNFAIP1 and SMAD4	;;cell migration;progression;cell migration;poor survival;metastasis;	colorectal cancer;colorectal cancer;lung squamous cell cancer;liver cancer;colorectal cancer;lung cancer
hsa-miR-30c-5p	SMAD4	-0.298383882401475	0.865809030482001	-0.473107439957935	0.714784528258547	mirMAP	-0.161864241902982	0.00997017208528321		NA	NA	NA
hsa-miR-335-3p	SMAD4	-0.244830745789445	0.88450019116631	-0.473107439957935	0.714784528258547	mirMAP	-0.152108913902534	0.000161782003808618		NA	NA	NA
hsa-miR-361-5p	SMAD4	-0.138735309928775	0.941495130308343	-0.473107439957935	0.714784528258547	mirMAP	-0.25694604812623	0.000622808366001207		NA	NA	NA
hsa-miR-369-3p	SMAD4	0.116576891957687	0.83230082995912	-0.473107439957935	0.714784528258547	mirMAP	-0.129702032821106	0.00443370777607746		NA	NA	NA
hsa-miR-374a-5p	SMAD4	-0.343007247142618	0.766921280269271	-0.473107439957935	0.714784528258547	mirMAP	-0.172312563460398	0.00687195386161141		NA	NA	NA
hsa-miR-374b-5p	SMAD4	-0.285682091626878	0.83569830479965	-0.473107439957935	0.714784528258547	mirMAP	-0.199204180191632	0.00121736577828174		NA	NA	NA
hsa-miR-377-3p	SMAD4	-0.0435868040110954	0.893514136702459	-0.473107439957935	0.714784528258547	MirTarget	-0.101669454382718	0.00980370784502512		NA	NA	NA
hsa-miR-425-5p	SMAD4	-0.354606074344121	0.845979106734409	-0.473107439957935	0.714784528258547	mirMAP	-0.130531407894903	0.00133502406681675		NA	NA	NA
hsa-miR-450b-5p	SMAD4	-0.0136687538973108	0.983149761399849	-0.473107439957935	0.714784528258547	mirMAP	-0.196219534294055	1.87736804832562e-05		NA	NA	NA
hsa-miR-454-3p	SMAD4	-0.101514866328011	0.843545158256191	-0.473107439957935	0.714784528258547	miRNAWalker2_validate;miRNATAP	-0.168274939805476	0.00152054988480945		NA	NA	NA
hsa-miR-500a-5p	SMAD4	-0.71978560736831	0.188073776225276	-0.473107439957935	0.714784528258547	mirMAP	-0.121458878900978	0.00137356923942353		NA	NA	NA
hsa-miR-539-5p	SMAD4	0.124342970087029	0.801067485473643	-0.473107439957935	0.714784528258547	mirMAP	-0.180979731505977	0.000193930709263202		NA	NA	NA
hsa-miR-92a-3p	SMAD4	0.0278830870766349	0.993247426671713	-0.473107439957935	0.714784528258547	miRNAWalker2_validate;mirMAP	-0.174217160676192	0.000127132683719261		NA	NA	NA
hsa-miR-181c-5p	SMC1A	0.042951891660695	0.969159991881861	-0.260713364920104	0.879877764068273	mirMAP	-0.124602020060787	0.00196682172618536		NA	NA	NA
hsa-miR-218-5p	SMC1A	0.233108057313884	0.810208076649842	-0.260713364920104	0.879877764068273	mirMAP	-0.12126722691003	0.000671739467734475		NA	NA	NA
hsa-miR-664a-3p	SMC1A	-0.00395670341813714	0.996119749372707	-0.260713364920104	0.879877764068273	mirMAP	-0.173203282587533	0.000305705063141742		NA	NA	NA
hsa-miR-140-5p	STAG1	-0.229213026275906	0.847330111738616	-0.178740138560687	0.878030723610316	miRanda	-0.137819139133958	0.00144922515425366		NA	NA	NA
hsa-miR-26b-5p	STAG1	-0.0245931278499594	0.990377966314923	-0.178740138560687	0.878030723610316	miRNAWalker2_validate	-0.150478802722378	0.000126997143447127		NA	NA	NA
hsa-miR-27a-3p	STAG1	-0.123902317731458	0.958804393510999	-0.178740138560687	0.878030723610316	MirTarget;miRNATAP	-0.193967053350934	3.52052584368954e-05		NA	NA	NA
hsa-miR-30b-5p	STAG1	-0.0121430518253582	0.994622896704513	-0.178740138560687	0.878030723610316	MirTarget	-0.124133552105336	1.54933924310989e-05		NA	NA	NA
hsa-miR-30c-5p	STAG1	-0.298383882401475	0.865809030482001	-0.178740138560687	0.878030723610316	MirTarget	-0.147501663893835	0.000375387078877926		NA	NA	NA
hsa-miR-495-3p	STAG1	0.00168200867117596	0.997533662527025	-0.178740138560687	0.878030723610316	mirMAP	-0.118560635670858	0.00145096865010031		NA	NA	NA
hsa-let-7i-3p	STAG2	-0.130677137887039	0.91387666391029	-0.05920190313274	0.97062484648949	MirTarget;miRNATAP	-0.162044255045653	5.42912109007539e-05		NA	NA	NA
hsa-miR-140-3p	STAG2	-0.369894078407761	0.864762211761539	-0.05920190313274	0.97062484648949	MirTarget;PITA;miRNATAP	-0.161891818292137	0.00936280655717545		NA	NA	NA
hsa-miR-155-5p	STAG2	-0.407235807706004	0.828669616718496	-0.05920190313274	0.97062484648949	miRNAWalker2_validate	-0.118067483796486	0.000704542795487221		NA	NA	NA
hsa-miR-22-3p	STAG2	0.0592693913158495	0.986564295498741	-0.05920190313274	0.97062484648949	MirTarget;miRNATAP	-0.26429495236797	1.43055144473093e-05		NA	NA	NA
hsa-miR-342-3p	STAG2	-0.371626144515113	0.77313668985267	-0.05920190313274	0.97062484648949	miRanda	-0.140978846263452	7.63951876613859e-05		NA	NA	NA
hsa-miR-34a-5p	STAG2	-0.50188164870224	0.742034237185732	-0.05920190313274	0.97062484648949	miRNAWalker2_validate;miRNATAP	-0.125256017842076	0.000929456419971783		NA	NA	NA
hsa-miR-495-3p	STAG2	0.00168200867117596	0.997533662527025	-0.05920190313274	0.97062484648949	MirTarget	-0.146337079249724	0.0010440565859246		NA	NA	NA
hsa-miR-92b-3p	STAG2	-0.569866984318692	0.689321861489779	-0.05920190313274	0.97062484648949	miRNATAP	-0.122929959913709	0.000286834883919113		NA	NA	NA
hsa-miR-30a-3p	TFDP1	0.250338313897394	0.917094926793447	0.240147693075618	0.888071721161161	MirTarget;miRNATAP	-0.195966466244305	0.000164898942060846		NA	NA	NA
hsa-miR-30a-5p	TFDP1	0.219472325612346	0.933954023293816	0.240147693075618	0.888071721161161	MirTarget;miRNATAP	-0.22202849781438	0.00016809674512808		NA	NA	NA
hsa-miR-365a-3p	TFDP1	0.0797451871548276	0.938758494058574	0.240147693075618	0.888071721161161	MirTarget	-0.158707050726629	0.00109754628430878		NA	NA	NA
hsa-miR-132-3p	TFDP2	-0.244143673573889	0.871752726220643	-0.169243917554684	0.854518222809419	mirMAP	-0.227530913740762	4.68303499924743e-05		NA	NA	NA
hsa-miR-146b-5p	TFDP2	-0.402662509440887	0.837510937985091	-0.169243917554684	0.854518222809419	MirTarget	-0.121762916100863	0.0035565565594526		NA	NA	NA
hsa-miR-212-3p	TFDP2	-0.0224067199236484	0.973232008101458	-0.169243917554684	0.854518222809419	mirMAP	-0.173932740473629	0.000113349496498478		NA	NA	NA
hsa-miR-22-5p	TFDP2	-0.0785922550675187	0.93169760098231	-0.169243917554684	0.854518222809419	mirMAP	-0.102006154967435	0.00403569697998392		NA	NA	NA
hsa-miR-29c-3p	TFDP2	0.162451700202704	0.942720457512509	-0.169243917554684	0.854518222809419	mirMAP	-0.11250301787163	0.00281111360465848		NA	NA	NA
hsa-miR-342-3p	TFDP2	-0.371626144515113	0.77313668985267	-0.169243917554684	0.854518222809419	miRNATAP	-0.112520120479651	0.00245588118537526		NA	NA	NA
hsa-miR-432-5p	TFDP2	0.207020069577775	0.751190124672628	-0.169243917554684	0.854518222809419	mirMAP	-0.129351172943431	0.00191631817791197		NA	NA	NA
hsa-miR-654-3p	TFDP2	0.0699248385448739	0.946997748280675	-0.169243917554684	0.854518222809419	mirMAP	-0.111497650718318	0.00595647738050231		NA	NA	NA
hsa-miR-92b-3p	TFDP2	-0.569866984318692	0.689321861489779	-0.169243917554684	0.854518222809419	MirTarget;miRNATAP	-0.137943808414635	8.01321010305913e-05		NA	NA	NA
hsa-miR-144-3p	TGFB1	0.0482420655617901	0.935871997593533	0.20606591055844	0.864135148758689	miRTarBase	-0.158176126715838	0.000455981186321274		NA	NA	NA
hsa-miR-29b-3p	TGFB1	-0.104016192263954	0.958988036765397	0.20606591055844	0.864135148758689	miRTarBase	-0.418904079644804	5.97577996681149e-09		NA	NA	NA
hsa-let-7a-3p	TGFB2	-0.215598045625677	0.85543299203799	0.566877582921754	0.302981050441313	miRNATAP	-0.509553196595548	1.6994890144512e-07		NA	NA	NA
hsa-miR-130b-3p	TGFB2	-0.221667315324818	0.824660172394714	0.566877582921754	0.302981050441313	MirTarget;miRNATAP	-0.484051596294314	8.89145164465726e-08		NA	NA	NA
hsa-miR-141-3p	TGFB2	-0.31994058840327	0.87774106909065	0.566877582921754	0.302981050441313	miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP	-0.453055156957619	8.49592670640955e-10		NA	NA	NA
hsa-miR-142-3p	TGFB2	-0.154235241441331	0.946098054588918	0.566877582921754	0.302981050441313	miRNATAP	-0.232355282039217	0.00153966616658786		NA	NA	NA
hsa-miR-142-5p	TGFB2	-0.118920788314118	0.929665277963083	0.566877582921754	0.302981050441313	mirMAP	-0.219369115404822	0.00680504214547402		NA	NA	NA
hsa-miR-148a-3p	TGFB2	-0.101286586375016	0.976980454193186	0.566877582921754	0.302981050441313	MirTarget;miRNATAP	-0.46318701252785	3.10804606849136e-07		NA	NA	NA
hsa-miR-148b-3p	TGFB2	-0.202106692287125	0.911884960581838	0.566877582921754	0.302981050441313	MirTarget	-0.55651714764531	1.71955467385875e-05		NA	NA	NA
hsa-miR-186-5p	TGFB2	-0.318786974828757	0.85412722938961	0.566877582921754	0.302981050441313	mirMAP	-0.658763474863498	9.43232781346235e-08		NA	NA	NA
hsa-miR-193a-3p	TGFB2	-0.247265785363732	0.654363581941634	0.566877582921754	0.302981050441313	MirTarget;miRanda;miRNATAP	-0.240773694665901	0.00434002606348744		NA	NA	NA
hsa-miR-200a-3p	TGFB2	-0.367034437440907	0.851059894150266	0.566877582921754	0.302981050441313	MirTarget;miRNATAP	-0.393177791645403	6.04013393821491e-08	25813153	Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC		kidney renal cell cancer
hsa-miR-203a-3p	TGFB2	-0.265248086637561	0.931593594361942	0.566877582921754	0.302981050441313	MirTarget	-0.346567340811647	1.20313347637985e-07		NA	NA	NA
hsa-miR-29a-3p	TGFB2	0.01127474410284	0.996977020481272	0.566877582921754	0.302981050441313	MirTarget;miRNATAP	-0.575630664666141	6.88773528918933e-07		NA	NA	NA
hsa-miR-29b-3p	TGFB2	-0.104016192263954	0.958988036765397	0.566877582921754	0.302981050441313	miRTarBase;MirTarget;miRNATAP	-0.520150522000126	1.98301663290379e-09		NA	NA	NA
hsa-miR-301a-3p	TGFB2	-0.105312511901769	0.831686745977347	0.566877582921754	0.302981050441313	MirTarget;miRNATAP	-0.27612545445948	0.000385597686723549		NA	NA	NA
hsa-miR-32-3p	TGFB2	-0.568003960723004	0.13133163420273	0.566877582921754	0.302981050441313	mirMAP	-0.411501778912108	4.65513477983269e-11		NA	NA	NA
hsa-miR-324-5p	TGFB2	-0.50063248413014	0.537416710557032	0.566877582921754	0.302981050441313	miRanda	-0.336340102670961	0.000359923455444418		NA	NA	NA
hsa-miR-331-5p	TGFB2	-0.450673082073933	0.250361590873666	0.566877582921754	0.302981050441313	miRNATAP	-0.389505552306975	8.94731124077219e-05		NA	NA	NA
hsa-miR-335-3p	TGFB2	-0.244830745789445	0.88450019116631	0.566877582921754	0.302981050441313	mirMAP	-0.413154502843607	2.72697980713492e-07		NA	NA	NA
hsa-miR-335-5p	TGFB2	-0.0284895175847679	0.973380867832231	0.566877582921754	0.302981050441313	miRNAWalker2_validate	-0.409411679068793	3.98124076510825e-07		NA	NA	NA
hsa-miR-33a-3p	TGFB2	-0.794543849238581	0.0105203072007922	0.566877582921754	0.302981050441313	MirTarget;mirMAP	-0.408250076739687	3.84332035251976e-08		NA	NA	NA
hsa-miR-362-3p	TGFB2	-0.721040238345347	0.0345881362485733	0.566877582921754	0.302981050441313	miRanda	-0.355323991152597	7.48809298588997e-07		NA	NA	NA
hsa-miR-362-5p	TGFB2	-0.26647467080141	0.752024885130738	0.566877582921754	0.302981050441313	MirTarget	-0.370650102758948	4.63810708635457e-08		NA	NA	NA
hsa-miR-374a-5p	TGFB2	-0.343007247142618	0.766921280269271	0.566877582921754	0.302981050441313	mirMAP	-0.590082040242667	3.21665468463847e-06		NA	NA	NA
hsa-miR-374b-5p	TGFB2	-0.285682091626878	0.83569830479965	0.566877582921754	0.302981050441313	mirMAP	-0.56445539974881	4.40383710254309e-06		NA	NA	NA
hsa-miR-375	TGFB2	-0.690952835064582	0.831716365337668	0.566877582921754	0.302981050441313	miRNAWalker2_validate	-0.202181245010158	0.00036513230561127		NA	NA	NA
hsa-miR-429	TGFB2	-0.456485631615963	0.806240953400535	0.566877582921754	0.302981050441313	miRNATAP	-0.403453846611381	5.10568073154813e-09		NA	NA	NA
hsa-miR-454-3p	TGFB2	-0.101514866328011	0.843545158256191	0.566877582921754	0.302981050441313	MirTarget;miRNATAP	-0.415241866764752	9.8183646229735e-05		NA	NA	NA
hsa-miR-500a-5p	TGFB2	-0.71978560736831	0.188073776225276	0.566877582921754	0.302981050441313	mirMAP	-0.337502696848928	8.62687089622154e-06		NA	NA	NA
hsa-miR-589-3p	TGFB2	-0.835836305204965	0.0112001563801511	0.566877582921754	0.302981050441313	MirTarget	-0.31190425828218	6.04695289795267e-06		NA	NA	NA
hsa-miR-590-3p	TGFB2	-0.279244755376859	0.59126669933662	0.566877582921754	0.302981050441313	mirMAP	-0.534073821286711	5.92202924180913e-14		NA	NA	NA
hsa-miR-590-5p	TGFB2	-0.547819833829572	0.472735645776647	0.566877582921754	0.302981050441313	miRanda;miRNATAP	-0.517762991776137	9.79723846830351e-12		NA	NA	NA
hsa-miR-7-5p	TGFB2	0.209645143210379	0.773705612298441	0.566877582921754	0.302981050441313	MirTarget	-0.223152315293427	6.21523733835928e-05		NA	NA	NA
hsa-let-7a-3p	TGFB3	-0.215598045625677	0.85543299203799	0.290973928352888	0.724980713991104	MirTarget	-0.683864247335398	2.32084912745715e-08		NA	NA	NA
hsa-let-7f-1-3p	TGFB3	-0.31101436822914	0.693407210545374	0.290973928352888	0.724980713991104	MirTarget	-0.920550529071741	3.76931882500923e-08		NA	NA	NA
hsa-miR-10a-5p	TGFB3	0.0740585720685925	0.983770933356406	0.290973928352888	0.724980713991104	miRNAWalker2_validate	-0.598760473914115	1.53805553632417e-08		NA	NA	NA
hsa-miR-151a-5p	TGFB3	-0.416333535986492	0.695673384848773	0.290973928352888	0.724980713991104	MirTarget	-0.80897372667275	3.51594518430166e-12		NA	NA	NA
hsa-miR-26b-3p	TGFB3	-0.363222538866814	0.681115126930068	0.290973928352888	0.724980713991104	MirTarget	-0.634118114736644	3.1640342294488e-08		NA	NA	NA
hsa-miR-29a-3p	TGFB3	0.01127474410284	0.996977020481272	0.290973928352888	0.724980713991104	miRNAWalker2_validate	-0.97578042792513	8.18301076737461e-12		NA	NA	NA
hsa-miR-29b-3p	TGFB3	-0.104016192263954	0.958988036765397	0.290973928352888	0.724980713991104	miRTarBase	-0.778433510463803	4.28162839239473e-13		NA	NA	NA
hsa-miR-590-3p	TGFB3	-0.279244755376859	0.59126669933662	0.290973928352888	0.724980713991104	miRanda	-0.694919331770113	7.31980174905473e-15		NA	NA	NA
hsa-miR-629-3p	TGFB3	-0.495402745812008	0.333967382214384	0.290973928352888	0.724980713991104	MirTarget	-0.463502025717243	1.99571609951234e-07		NA	NA	NA
hsa-miR-139-5p	TTK	-0.0810891026597322	0.928690377743652	-0.193630520009775	0.851785919419224	miRanda	-0.182065898080716	0.000104524125584368		NA	NA	NA
hsa-miR-146b-5p	WEE1	-0.402662509440887	0.837510937985091	-0.233999490620905	0.855668020281583	miRanda	-0.12452735216635	0.00389357996161025		NA	NA	NA
hsa-miR-338-3p	WEE1	0.49158501750012	0.788483749194189	-0.233999490620905	0.855668020281583	miRanda	-0.101321001175907	0.000301065118814514		NA	NA	NA
hsa-miR-132-3p	YWHAB	-0.244143673573889	0.871752726220643	0.268492923780645	0.897700515695515	MirTarget	-0.18806375055171	0.00189416692640873		NA	NA	NA
hsa-miR-330-3p	YWHAB	0.00298687748748416	0.994504006750491	0.268492923780645	0.897700515695515	MirTarget;PITA	-0.117570493699089	0.00654102490230821		NA	NA	NA
hsa-miR-100-5p	YWHAE	0.0230258429671419	0.992818348620337	-0.138575101196187	0.946623595756686	miRNAWalker2_validate	-0.120562901672456	8.58625884415223e-06		NA	NA	NA
hsa-miR-199a-3p	YWHAE	0.0782166873040424	0.973766909565326	-0.138575101196187	0.946623595756686	MirTarget;PITA;miRNATAP	-0.109292308891936	0.00757704489929994		NA	NA	NA
hsa-miR-199a-5p	YWHAE	0.157247797504494	0.935797462797012	-0.138575101196187	0.946623595756686	miRanda	-0.12397348360088	0.00101562574044864		NA	NA	NA
hsa-miR-199b-3p	YWHAE	0.0780653337513897	0.973815251150337	-0.138575101196187	0.946623595756686	MirTarget;PITA;miRNATAP	-0.109211349134326	0.00762217119708688		NA	NA	NA
hsa-miR-30a-3p	YWHAE	0.250338313897394	0.917094926793447	-0.138575101196187	0.946623595756686	miRNAWalker2_validate;MirTarget;miRNATAP	-0.176312896763582	0.000106750398372577		NA	NA	NA
hsa-miR-30a-5p	YWHAE	0.219472325612346	0.933954023293816	-0.138575101196187	0.946623595756686	miRNAWalker2_validate	-0.227892668616782	9.06521083943401e-06		NA	NA	NA
hsa-miR-23b-3p	YWHAG	-0.10822254818704	0.961352920317636	-0.0391520245774739	0.983081423028695	MirTarget;miRNATAP	-0.115715051130517	0.00775699813228171		NA	NA	NA
hsa-miR-30e-5p	YWHAG	-0.0657075181381011	0.979684509181941	-0.0391520245774739	0.983081423028695	miRNATAP	-0.15442784470344	2.71338646255962e-05		NA	NA	NA
hsa-miR-139-5p	YWHAQ	-0.0810891026597322	0.928690377743652	0.0826476345455838	0.965635074886716	MirTarget;PITA;miRanda;miRNATAP	-0.102836765005167	0.00026663023384852		NA	NA	NA
hsa-miR-140-5p	YWHAQ	-0.229213026275906	0.847330111738616	0.0826476345455838	0.965635074886716	miRanda	-0.131618682474264	0.00107757909343137		NA	NA	NA
hsa-miR-145-3p	YWHAQ	0.134827892912136	0.913156302847575	0.0826476345455838	0.965635074886716	MirTarget;miRNATAP	-0.127870021749012	9.64101490771534e-05		NA	NA	NA
hsa-miR-27a-3p	YWHAQ	-0.123902317731458	0.958804393510999	0.0826476345455838	0.965635074886716	MirTarget	-0.121677680598632	0.00581404335298484		NA	NA	NA
hsa-miR-27b-3p	YWHAQ	-0.14277121795778	0.951937409841932	0.0826476345455838	0.965635074886716	MirTarget	-0.186553804415952	0.000211073817991096		NA	NA	NA
hsa-miR-328-3p	YWHAQ	-0.27090542057371	0.758001839490036	0.0826476345455838	0.965635074886716	miRNAWalker2_validate	-0.142782029703957	1.81063391745289e-06		NA	NA	NA
hsa-miR-497-5p	YWHAQ	-0.0120217191428731	0.989147225742026	0.0826476345455838	0.965635074886716	MirTarget;miRNATAP	-0.187258093691752	1.06417785486781e-08		NA	NA	NA
hsa-miR-199a-3p	YWHAZ	0.0782166873040424	0.973766909565326	-0.0576420671060323	0.980589660363914	MirTarget	-0.114139275111848	0.00473898120199714		NA	NA	NA
hsa-miR-199a-5p	YWHAZ	0.157247797504494	0.935797462797012	-0.0576420671060323	0.980589660363914	miRanda	-0.120463700457026	0.00124102929646691		NA	NA	NA
hsa-miR-199b-3p	YWHAZ	0.0780653337513897	0.973815251150337	-0.0576420671060323	0.980589660363914	MirTarget	-0.114089745391343	0.00475721105978957		NA	NA	NA
hsa-miR-22-3p	YWHAZ	0.0592693913158495	0.986564295498741	-0.0576420671060323	0.980589660363914	MirTarget	-0.160711801138276	0.0060701669558579		NA	NA	NA
hsa-miR-30e-5p	YWHAZ	-0.0657075181381011	0.979684509181941	-0.0576420671060323	0.980589660363914	MirTarget;miRNATAP	-0.140789168239452	0.00739940560791832		NA	NA	NA
hsa-miR-328-3p	YWHAZ	-0.27090542057371	0.758001839490036	-0.0576420671060323	0.980589660363914	MirTarget	-0.1359967552498	0.000235753753264675		NA	NA	NA
hsa-miR-34c-5p	YWHAZ	-0.018707656771723	0.952788306178575	-0.0576420671060323	0.980589660363914	miRanda	-0.10452079235571	0.00184231244437824		NA	NA	NA
hsa-miR-708-3p	YWHAZ	0.137785606206693	0.896980471394499	-0.0576420671060323	0.980589660363914	mirMAP	-0.102981853394496	0.00113142770330167		NA	NA	NA