miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-200c-3p	ABAT	6.44310729207051	0.0482567211582212	0.122897473992331	0.904280001904206	MirTarget	-0.176087024283366	0.00957306151711354		NA	NA	NA
hsa-miR-200c-3p	ACTC1	6.44310729207051	0.0482567211582212	-6.29485820334419	2.12370297349949e-05	MirTarget	-0.546107320999917	2.94356637771889e-06		NA	NA	NA
hsa-miR-200c-3p	ADAMTS3	6.44310729207051	0.0482567211582212	-3.41239050742556	0.0036168922023655	miRNATAP	-0.377623015524411	6.02959622939037e-05		NA	NA	NA
hsa-miR-200c-3p	ADCY2	6.44310729207051	0.0482567211582212	-6.09132337564378	3.84596403196057e-05	MirTarget;miRNATAP	-0.371982978074438	0.00505555237095131		NA	NA	NA
hsa-miR-200c-3p	AFF3	6.44310729207051	0.0482567211582212	-4.85369177740477	2.03691060022282e-07	MirTarget;miRNATAP	-0.55212265723495	3.9391188482878e-12		NA	NA	NA
hsa-miR-200c-3p	AMOTL2	6.44310729207051	0.0482567211582212	-0.848899405845526	0.574083728889471	MirTarget;miRNATAP	-0.1343557040744	0.00723410166044823		NA	NA	NA
hsa-miR-200c-3p	AP1S2	6.44310729207051	0.0482567211582212	-2.9449540267591	0.00155875653399482	MirTarget;miRNATAP	-0.329480064216835	4.3008369341744e-16		NA	NA	NA
hsa-miR-200c-3p	ARHGAP20	6.44310729207051	0.0482567211582212	-3.46396357097426	0.00118610351627329	MirTarget;miRNATAP	-0.516261457247328	2.17434195128011e-09		NA	NA	NA
hsa-miR-200c-3p	ARHGAP28	6.44310729207051	0.0482567211582212	-2.42359750996565	0.0513738366635826	MirTarget	-0.356547032207822	0.000798253720239243		NA	NA	NA
hsa-miR-200c-3p	ARHGAP6	6.44310729207051	0.0482567211582212	-5.56780093591955	8.38718919463613e-10	MirTarget	-0.509431171385338	4.910827342572e-11		NA	NA	NA
hsa-miR-200c-3p	ARHGEF17	6.44310729207051	0.0482567211582212	-2.25635449629268	0.0867087498634809	miRNATAP	-0.177995834255429	2.33933461504506e-05		NA	NA	NA
hsa-miR-200c-3p	ARL15	6.44310729207051	0.0482567211582212	-0.832361512524658	0.369403317541064	MirTarget	-0.149955520240535	0.00285758919987027		NA	NA	NA
hsa-miR-200c-3p	ARL2BP	6.44310729207051	0.0482567211582212	-0.872451549869182	0.502345164889293	miRNATAP	-0.124247276368815	1.38801634754115e-06		NA	NA	NA
hsa-miR-200c-3p	ASAP1	6.44310729207051	0.0482567211582212	-0.0612038629849829	0.961564879482836	MirTarget;miRNATAP	-0.106052957666657	0.002535587931351		NA	NA	NA
hsa-miR-200c-3p	ATP11C	6.44310729207051	0.0482567211582212	-0.880681123541884	0.450457495927429	MirTarget	-0.107430150824264	0.0148151301443591		NA	NA	NA
hsa-miR-200c-3p	ATXN1	6.44310729207051	0.0482567211582212	-1.44004935955406	0.252648644472153	MirTarget;miRNATAP	-0.179479344164765	2.07717421988575e-05		NA	NA	NA
hsa-miR-200c-3p	BASP1	6.44310729207051	0.0482567211582212	-0.813938562211783	0.547272266836444	miRNATAP	-0.291463690661245	0.00303872235672823		NA	NA	NA
hsa-miR-200c-3p	BCL2	6.44310729207051	0.0482567211582212	-3.00222034638437	0.00288703323344775	miRNAWalker2_validate;miRTarBase	-0.20320611228092	0.000726337324039896		NA	NA	NA
hsa-miR-200c-3p	BNC2	6.44310729207051	0.0482567211582212	-6.05110333558987	8.93817787746877e-10	MirTarget	-0.65280193687476	1.38699243353219e-16		NA	NA	NA
hsa-miR-200c-3p	C11orf87	6.44310729207051	0.0482567211582212	-4.00633151886511	0.0161837363084897	miRNATAP	-0.406441450283731	0.000117064165995019		NA	NA	NA
hsa-miR-200c-3p	CACNA1C	6.44310729207051	0.0482567211582212	-5.60267132645174	3.55350210390833e-09	MirTarget	-0.479623033848176	3.52519696145397e-11		NA	NA	NA
hsa-miR-200c-3p	CALU	6.44310729207051	0.0482567211582212	-0.869384315420985	0.623682475243959	MirTarget	-0.108838924612178	0.00144274968876235		NA	NA	NA
hsa-miR-200c-3p	CBL	6.44310729207051	0.0482567211582212	-0.204423887424826	0.868364762446413	MirTarget	-0.102551823392254	0.00480588017413537		NA	NA	NA
hsa-miR-200c-3p	CDK17	6.44310729207051	0.0482567211582212	-1.04278459829028	0.336894173045522	MirTarget;miRNATAP	-0.106273110517668	0.000228667988246372		NA	NA	NA
hsa-miR-200c-3p	CELF2	6.44310729207051	0.0482567211582212	-2.38167803280656	0.0190273305404551	miRNATAP	-0.269914129826243	4.00377211196354e-05		NA	NA	NA
hsa-miR-200c-3p	CEP68	6.44310729207051	0.0482567211582212	-1.72421407092376	0.106279696008149	MirTarget	-0.125803290215139	0.000205071181607758		NA	NA	NA
hsa-miR-200c-3p	CFL2	6.44310729207051	0.0482567211582212	-3.41931580342507	0.00479590598144908	MirTarget;miRNATAP	-0.214648789643005	2.10821306697854e-06	23497265	We characterized one of the target genes of miR-200c CFL2 and demonstrated that CFL2 is overexpressed in aggressive breast cancer cell lines and can be significantly down-regulated by exogenous miR-200c		breast cancer
hsa-miR-200c-3p	CHD9	6.44310729207051	0.0482567211582212	-0.244031146620716	0.848561887538967	miRNATAP	-0.10736843868053	0.00300541602750714		NA	NA	NA
hsa-miR-200c-3p	CHN2	6.44310729207051	0.0482567211582212	-2.74015971170682	0.00636411833738762	MirTarget	-0.184724590702903	0.0174623578097875		NA	NA	NA
hsa-miR-200c-3p	CHRDL1	6.44310729207051	0.0482567211582212	-10.0364657259181	1.8489281919052e-08	MirTarget	-0.925481894290808	3.10515468942422e-10		NA	NA	NA
hsa-miR-200c-3p	CHST2	6.44310729207051	0.0482567211582212	-0.313738445438171	0.782683320031062	miRNATAP	-0.202833959724376	0.0208239294825107		NA	NA	NA
hsa-miR-200c-3p	CITED2	6.44310729207051	0.0482567211582212	-2.87819832001324	0.0316336512265267	miRNATAP	-0.147426120705614	0.00238275307632587		NA	NA	NA
hsa-miR-200c-3p	CLIC4	6.44310729207051	0.0482567211582212	-1.9930238374952	0.243874902849554	MirTarget;miRNATAP	-0.195597387706071	4.82051350167941e-07		NA	NA	NA
hsa-miR-200c-3p	CLIP2	6.44310729207051	0.0482567211582212	-1.95986243088393	0.13839062742435	MirTarget;miRNATAP	-0.182968711488553	0.000630181793591354		NA	NA	NA
hsa-miR-200c-3p	CNN3	6.44310729207051	0.0482567211582212	-1.91322977092568	0.263170643695134	MirTarget;miRNATAP	-0.164602763860358	6.48264308341628e-05		NA	NA	NA
hsa-miR-200c-3p	CNTFR	6.44310729207051	0.0482567211582212	-3.84295336420734	0.0456805779463983	miRNATAP	-0.615684884366288	9.14142247953298e-05		NA	NA	NA
hsa-miR-200c-3p	CNTN1	6.44310729207051	0.0482567211582212	-2.59114691685987	0.163258160284073	MirTarget;miRNATAP	-0.315621149840789	0.0497185320835011		NA	NA	NA
hsa-miR-200c-3p	CNTN4	6.44310729207051	0.0482567211582212	-4.66974986718344	6.33736181279991e-05	miRNATAP	-0.471522441885607	2.59981820726047e-06		NA	NA	NA
hsa-miR-200c-3p	CREB5	6.44310729207051	0.0482567211582212	-1.84895021196819	0.146075261093573	miRNATAP	-0.2309175228535	0.0102400833474917		NA	NA	NA
hsa-miR-200c-3p	CTNND2	6.44310729207051	0.0482567211582212	-1.51065788303426	0.32135654195425	MirTarget;miRNATAP	-0.245961430961862	0.0247326605868547		NA	NA	NA
hsa-miR-200c-3p	CYP1B1	6.44310729207051	0.0482567211582212	-3.7570349151348	0.00499288321559356	miRNATAP	-0.497408205529593	2.46288631919149e-07	25860934	Loss of miR 200c up regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma; Additionally miR-200c which is significantly down-regulated in RCC regulates CYP1B1 expression and activity; An inverse association was also observed between the expression levels of miR-200c and CYP1B1 protein in RCC tissues; Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c; These results suggest that CYP1B1 up-regulation mediated by low miR-200c is one of the mechanisms underlying resistance of RCC cells to docetaxel; Therefore expression of CYP1B1 and miR-200c in RCC may be useful as a prediction for docetaxel response	drug resistance	kidney renal cell cancer
hsa-miR-200c-3p	CYTH3	6.44310729207051	0.0482567211582212	-1.4641931829368	0.220019430601819	MirTarget	-0.141835316685997	0.000226715870882542		NA	NA	NA
hsa-miR-200c-3p	DACT1	6.44310729207051	0.0482567211582212	-3.43485370324909	0.00179722932037183	miRNATAP	-0.474491739937372	6.12627091264792e-08		NA	NA	NA
hsa-miR-200c-3p	DDIT4L	6.44310729207051	0.0482567211582212	-4.71505305314779	0.000868223481831181	MirTarget	-0.292172761150777	0.021980655562321		NA	NA	NA
hsa-miR-200c-3p	DIXDC1	6.44310729207051	0.0482567211582212	-4.41472894663933	1.27934663099293e-05	MirTarget	-0.353592604761699	4.47380227953535e-10		NA	NA	NA
hsa-miR-200c-3p	DLC1	6.44310729207051	0.0482567211582212	-3.77830056173261	0.000539554583069758	miRNATAP	-0.386976097352615	9.21849256423053e-10		NA	NA	NA
hsa-miR-200c-3p	DMD	6.44310729207051	0.0482567211582212	-4.18890126197959	0.000939996170753014	miRNATAP	-0.28173848896209	0.00540254454581762		NA	NA	NA
hsa-miR-200c-3p	DNAJB5	6.44310729207051	0.0482567211582212	-2.26407218193906	0.0167385049599496	miRNATAP	-0.262201490555372	1.02025422901768e-06		NA	NA	NA
hsa-miR-200c-3p	DOCK4	6.44310729207051	0.0482567211582212	-2.04260121878603	0.0106520560224087	MirTarget	-0.331545251837473	3.77016361385232e-11		NA	NA	NA
hsa-miR-200c-3p	DTNA	6.44310729207051	0.0482567211582212	-4.61090733834351	1.74495324590552e-05	MirTarget	-0.379951492240245	4.53528811258158e-05		NA	NA	NA
hsa-miR-200c-3p	DUSP1	6.44310729207051	0.0482567211582212	-2.25347512192581	0.233582986370653	MirTarget;miRNATAP	-0.192770736593645	0.0147008681259181		NA	NA	NA
hsa-miR-200c-3p	DZIP1	6.44310729207051	0.0482567211582212	-2.66343414243464	0.0187278389095853	MirTarget	-0.311418047070293	9.05378687549317e-05		NA	NA	NA
hsa-miR-200c-3p	EDNRA	6.44310729207051	0.0482567211582212	-3.90261738708969	0.00075250813720437	miRNAWalker2_validate;miRNATAP	-0.479548188974558	1.22281107078253e-10		NA	NA	NA
hsa-miR-200c-3p	ENTPD1	6.44310729207051	0.0482567211582212	-1.62902619966225	0.206478573960647	MirTarget	-0.174364585691801	3.39368231396043e-10		NA	NA	NA
hsa-miR-200c-3p	ETS1	6.44310729207051	0.0482567211582212	-1.33209523846159	0.371782117040427	MirTarget;miRNATAP	-0.209867722791062	3.95532142095979e-05		NA	NA	NA
hsa-miR-200c-3p	ETV5	6.44310729207051	0.0482567211582212	-1.26340438834875	0.343756201279964	MirTarget;miRNATAP	-0.153736455813165	0.0399301778462555	27276064	Another study suggested that ERM expression was regulated directly by miR-200c and had a critical role in miR-200c suppressing cell migration	cell migration	breast cancer
hsa-miR-200c-3p	F2RL2	6.44310729207051	0.0482567211582212	-2.15881941658894	0.032631123443371	MirTarget	-0.342115715447424	5.70118920152878e-05		NA	NA	NA
hsa-miR-200c-3p	FAM19A2	6.44310729207051	0.0482567211582212	-2.12674128837464	0.0147752708530087	MirTarget	-0.185829536509174	0.0130187258177474		NA	NA	NA
hsa-miR-200c-3p	FAT3	6.44310729207051	0.0482567211582212	-3.4224072998101	0.0283191882635162	MirTarget;miRNATAP	-0.493080682893644	5.51987019676858e-05		NA	NA	NA
hsa-miR-200c-3p	FBLN5	6.44310729207051	0.0482567211582212	-4.98037274131345	0.000158915215215403	miRNAWalker2_validate;miRTarBase	-0.415830464291299	1.53051300969547e-09		NA	NA	NA
hsa-miR-200c-3p	FGF18	6.44310729207051	0.0482567211582212	-3.50602012195201	0.00273995134903927	miRNATAP	-0.259861479583255	0.0216691149135961		NA	NA	NA
hsa-miR-200c-3p	FHL1	6.44310729207051	0.0482567211582212	-6.4158909104408	2.99177197387409e-07	MirTarget	-0.700838731083137	1.22503641568997e-15		NA	NA	NA
hsa-miR-200c-3p	FLI1	6.44310729207051	0.0482567211582212	-2.34965249690394	0.00534299612441581	MirTarget;miRNATAP	-0.294850358848586	2.07871729673619e-07		NA	NA	NA
hsa-miR-200c-3p	FLNA	6.44310729207051	0.0482567211582212	-2.55762580734527	0.2449214533039	miRNAWalker2_validate	-0.288078196729452	1.44623491387617e-07		NA	NA	NA
hsa-miR-200c-3p	FLT1	6.44310729207051	0.0482567211582212	-2.50639861523246	0.0360764870768525	miRNAWalker2_validate;miRTarBase;MirTarget	-0.219736582761241	1.38560548333365e-05		NA	NA	NA
hsa-miR-200c-3p	FN1	6.44310729207051	0.0482567211582212	-1.23756841482652	0.563087552855619	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.527098065662119	1.20069978407088e-07		NA	NA	NA
hsa-miR-200c-3p	FOXF1	6.44310729207051	0.0482567211582212	-3.17913433973308	0.000247971779127763	MirTarget	-0.214184034897512	0.00153397000413562		NA	NA	NA
hsa-miR-200c-3p	FOXK1	6.44310729207051	0.0482567211582212	-0.359395134849994	0.792277783934752	miRNATAP	-0.105967092436231	0.00931282793767801		NA	NA	NA
hsa-miR-200c-3p	FRMD6	6.44310729207051	0.0482567211582212	-1.10160329364246	0.309828069303614	miRNATAP	-0.318497228385608	5.01705490615743e-05		NA	NA	NA
hsa-miR-200c-3p	FSTL1	6.44310729207051	0.0482567211582212	-2.23833384367357	0.240509099866307	MirTarget	-0.236502542187358	0.000315797242807464		NA	NA	NA
hsa-miR-200c-3p	FYN	6.44310729207051	0.0482567211582212	-2.6028247458249	0.0159200695043207	miRNATAP	-0.264473261620085	3.33090181572032e-06		NA	NA	NA
hsa-miR-200c-3p	GEM	6.44310729207051	0.0482567211582212	-3.78630340483655	0.00118991080814333	MirTarget;miRNATAP	-0.330688787908482	1.5445873565411e-06		NA	NA	NA
hsa-miR-200c-3p	GJC1	6.44310729207051	0.0482567211582212	-2.9280924111882	0.0117093948312718	MirTarget;miRNATAP	-0.174809064783533	0.0197720188976919		NA	NA	NA
hsa-miR-200c-3p	GLI3	6.44310729207051	0.0482567211582212	-1.47718989834118	0.130037351240238	miRNATAP	-0.439330740831604	6.22921073880638e-07		NA	NA	NA
hsa-miR-200c-3p	GLIS2	6.44310729207051	0.0482567211582212	-1.54382710080009	0.271053648570587	miRNATAP	-0.160372306430396	0.0101553466870972		NA	NA	NA
hsa-miR-200c-3p	GPM6A	6.44310729207051	0.0482567211582212	-8.90272244136849	8.53109331549644e-09	miRNATAP	-0.675314147001143	2.07599666453414e-09		NA	NA	NA
hsa-miR-200c-3p	GPR146	6.44310729207051	0.0482567211582212	-3.27971365070476	1.89641151779755e-07	miRNATAP	-0.106234807193481	0.017279723347311		NA	NA	NA
hsa-miR-200c-3p	GPRASP2	6.44310729207051	0.0482567211582212	-3.00942126264914	0.000262112466588205	MirTarget	-0.214671245767348	1.97322651540643e-05		NA	NA	NA
hsa-miR-200c-3p	GREM1	6.44310729207051	0.0482567211582212	-1.7754476657472	0.170218612415965	MirTarget	-0.405948813795272	2.47036834650093e-05		NA	NA	NA
hsa-miR-200c-3p	HCFC2	6.44310729207051	0.0482567211582212	-0.895384737078138	0.293905616205349	miRNATAP	-0.121279689918209	1.64945292614211e-05		NA	NA	NA
hsa-miR-200c-3p	HIVEP3	6.44310729207051	0.0482567211582212	1.37802161089398	0.10595986046871	miRNATAP	-0.242895016391104	0.000472939963069497		NA	NA	NA
hsa-miR-200c-3p	HLF	6.44310729207051	0.0482567211582212	-3.99614463618759	0.000727402105230808	MirTarget;miRNATAP	-0.340725404223469	0.000845497666448309		NA	NA	NA
hsa-miR-200c-3p	IRS1	6.44310729207051	0.0482567211582212	-2.42804893553438	0.0648706958514649	miRNATAP	-0.327926991247788	3.09985403660766e-06		NA	NA	NA
hsa-miR-200c-3p	ITGA1	6.44310729207051	0.0482567211582212	-1.34183857670103	0.272165507447703	MirTarget	-0.204503030574105	0.00123950956879595		NA	NA	NA
hsa-miR-200c-3p	ITPR1	6.44310729207051	0.0482567211582212	-3.64543462084327	0.000260396236925595	miRNATAP	-0.364865307181095	3.63686972563552e-11		NA	NA	NA
hsa-miR-200c-3p	ITPR2	6.44310729207051	0.0482567211582212	-0.250536085558021	0.817855843032248	MirTarget	-0.133718682464233	0.00652096509525488		NA	NA	NA
hsa-miR-200c-3p	JAG1	6.44310729207051	0.0482567211582212	0.579100047011072	0.708064501250061	miRNAWalker2_validate	-0.227366368433358	0.000148958094017213		NA	NA	NA
hsa-miR-200c-3p	JAZF1	6.44310729207051	0.0482567211582212	-3.33450240994219	0.00103064756409687	MirTarget;miRNATAP	-0.288423748176846	9.68034093913837e-09		NA	NA	NA
hsa-miR-200c-3p	JUN	6.44310729207051	0.0482567211582212	-1.33621390429592	0.494289178622199	MirTarget	-0.119095512777692	0.0217712883284784		NA	NA	NA
hsa-miR-200c-3p	KANK1	6.44310729207051	0.0482567211582212	-1.79290691270705	0.163051453145985	MirTarget	-0.210989777942739	5.67684420867331e-05		NA	NA	NA
hsa-miR-200c-3p	KCND2	6.44310729207051	0.0482567211582212	-2.70957443054184	0.0105476916693305	MirTarget;miRNATAP	-0.373883204501959	1.16137405581179e-05		NA	NA	NA
hsa-miR-200c-3p	KCTD15	6.44310729207051	0.0482567211582212	0.0819609766730141	0.946453219486064	MirTarget;miRNATAP	-0.165201135928022	0.00987793429434626		NA	NA	NA
hsa-miR-200c-3p	KDR	6.44310729207051	0.0482567211582212	-3.81719549705652	0.000212116507673073	miRNATAP	-0.382297274517525	9.67613306032587e-11	24205206	MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c		lung squamous cell cancer
hsa-miR-200c-3p	KIAA0040	6.44310729207051	0.0482567211582212	-0.719741024496817	0.593037816597232	MirTarget	-0.114078355300315	0.0125466943973234		NA	NA	NA
hsa-miR-200c-3p	KIAA1462	6.44310729207051	0.0482567211582212	-4.26082253001417	3.2091550046295e-05	MirTarget	-0.362404990740333	1.38802396781597e-09		NA	NA	NA
hsa-miR-200c-3p	KIF13A	6.44310729207051	0.0482567211582212	-0.673480306781514	0.576448998980722	miRNATAP	-0.103988661199238	0.049867636635376		NA	NA	NA
hsa-miR-200c-3p	KLF9	6.44310729207051	0.0482567211582212	-3.74328733470567	0.00312299645916023	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.24483741970432	1.64459844697795e-05		NA	NA	NA
hsa-miR-200c-3p	KLHDC1	6.44310729207051	0.0482567211582212	-2.4373965913819	0.000319760990920619	MirTarget	-0.182932970212369	0.00124743119239423		NA	NA	NA
hsa-miR-200c-3p	KLHL3	6.44310729207051	0.0482567211582212	-1.99517647777594	0.0104557977953249	miRNATAP	-0.179777143775817	0.00349122539275336		NA	NA	NA
hsa-miR-200c-3p	LAMC1	6.44310729207051	0.0482567211582212	-1.18751578429292	0.523847855400256	MirTarget;miRNATAP	-0.105453274620074	0.0325569747442994		NA	NA	NA
hsa-miR-200c-3p	LATS2	6.44310729207051	0.0482567211582212	-1.66007440561931	0.130924599558406	miRNATAP	-0.142079684531404	0.000588434621432939		NA	NA	NA
hsa-miR-200c-3p	LCA5	6.44310729207051	0.0482567211582212	-1.91287310640488	0.0278169941796784	MirTarget	-0.12426153113947	0.0351595970979669		NA	NA	NA
hsa-miR-200c-3p	LHFP	6.44310729207051	0.0482567211582212	-3.69079544977531	0.000396921102375579	MirTarget;miRNATAP	-0.361215681088172	9.47627414095923e-11		NA	NA	NA
hsa-miR-200c-3p	LIX1L	6.44310729207051	0.0482567211582212	-2.88405704703907	0.00682507267724305	MirTarget	-0.247156418648236	5.95063808282489e-09		NA	NA	NA
hsa-miR-200c-3p	MAF	6.44310729207051	0.0482567211582212	-1.29046922843151	0.262066964356738	miRNATAP	-0.278681449219642	0.000315320615768877		NA	NA	NA
hsa-miR-200c-3p	MARCH1	6.44310729207051	0.0482567211582212	1.44158858428573	0.0271185138993181	MirTarget	-0.147583259051473	0.00829553193131831		NA	NA	NA
hsa-miR-200c-3p	MARCH8	6.44310729207051	0.0482567211582212	-0.90571076157381	0.297836641974176	MirTarget	-0.158559243057284	0.00606423758334442		NA	NA	NA
hsa-miR-200c-3p	MBNL2	6.44310729207051	0.0482567211582212	-1.06457999964772	0.433665632196849	miRNATAP	-0.118534463731954	0.0137699781800238		NA	NA	NA
hsa-miR-200c-3p	MEGF10	6.44310729207051	0.0482567211582212	-3.69860769629444	0.00230307665992553	MirTarget	-0.3725195347424	3.66886063607833e-05		NA	NA	NA
hsa-miR-200c-3p	MEX3B	6.44310729207051	0.0482567211582212	-1.95171747703929	0.038933648017338	miRNATAP	-0.230222802346263	0.00102734946698581		NA	NA	NA
hsa-miR-200c-3p	MFAP5	6.44310729207051	0.0482567211582212	-5.84282504163476	0.00044928275365155	miRNATAP	-0.544156350624235	0.000150370227131591		NA	NA	NA
hsa-miR-200c-3p	MITF	6.44310729207051	0.0482567211582212	-4.68463242910007	5.02434509077098e-05	miRNATAP	-0.299301868172581	1.75377873530351e-06		NA	NA	NA
hsa-miR-200c-3p	MPDZ	6.44310729207051	0.0482567211582212	-3.49618760883983	0.00292344590367797	MirTarget	-0.232884376823939	0.00827351781888252		NA	NA	NA
hsa-miR-200c-3p	MPRIP	6.44310729207051	0.0482567211582212	-1.58799854412794	0.3231095149577	MirTarget;miRNATAP	-0.106288230414394	0.00142879564765599		NA	NA	NA
hsa-miR-200c-3p	MRVI1	6.44310729207051	0.0482567211582212	-4.89818149559032	1.31699431077689e-06	MirTarget	-0.519672737308513	5.93447120709013e-16		NA	NA	NA
hsa-miR-200c-3p	MSN	6.44310729207051	0.0482567211582212	-0.3120638464357	0.861683444418676	miRNAWalker2_validate;miRTarBase;MirTarget	-0.321345862085297	1.54777337357093e-07		NA	NA	NA
hsa-miR-200c-3p	MTSS1L	6.44310729207051	0.0482567211582212	-0.785464405165813	0.589736768274666	miRNATAP	-0.10131072949052	0.0305765880739815		NA	NA	NA
hsa-miR-200c-3p	NALCN	6.44310729207051	0.0482567211582212	-3.05350572762765	0.0461661016570051	MirTarget	-0.400347075803386	0.000384615238056382		NA	NA	NA
hsa-miR-200c-3p	NAP1L5	6.44310729207051	0.0482567211582212	-2.45591816508151	0.00580568908924974	MirTarget;miRNATAP	-0.139583462740228	0.0280436806406965		NA	NA	NA
hsa-miR-200c-3p	NCAM1	6.44310729207051	0.0482567211582212	-7.28822757252532	3.75905069185433e-13	miRTarBase	-0.540439960575067	2.69102010482828e-10		NA	NA	NA
hsa-miR-200c-3p	NCS1	6.44310729207051	0.0482567211582212	-1.2403229693109	0.312896331595911	miRNATAP	-0.248967045963907	1.03601447860477e-06		NA	NA	NA
hsa-miR-200c-3p	NDN	6.44310729207051	0.0482567211582212	-5.08880250885539	1.87786318212312e-07	MirTarget;miRNATAP	-0.459194559205779	1.37577730641789e-11		NA	NA	NA
hsa-miR-200c-3p	NDST1	6.44310729207051	0.0482567211582212	-0.0231677835280779	0.987420450894517	miRNATAP	-0.132268148873171	0.00125077398075564		NA	NA	NA
hsa-miR-200c-3p	NEGR1	6.44310729207051	0.0482567211582212	-5.36717683409666	4.48511413987919e-07	miRNATAP	-0.514861091396306	1.12304501689442e-08		NA	NA	NA
hsa-miR-200c-3p	NEK9	6.44310729207051	0.0482567211582212	-0.994471241068355	0.493887822306524	MirTarget	-0.105193649404319	1.3377282125954e-05		NA	NA	NA
hsa-miR-200c-3p	NFASC	6.44310729207051	0.0482567211582212	-2.05245828549247	0.0412823385912844	miRNATAP	-0.464630284589045	4.68601017195164e-07	23185507	miR 200c targets a NF κB up regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer		breast cancer
hsa-miR-200c-3p	NFIA	6.44310729207051	0.0482567211582212	-0.837678854055674	0.578332256898625	MirTarget;miRNATAP	-0.124003650379887	0.0182722084696979		NA	NA	NA
hsa-miR-200c-3p	NLGN4X	6.44310729207051	0.0482567211582212	-3.23794035959112	0.045344400438381	miRNATAP	-0.478863073282079	0.00052616534710615		NA	NA	NA
hsa-miR-200c-3p	NOVA1	6.44310729207051	0.0482567211582212	-6.40336945611471	6.95319246740273e-07	MirTarget;miRNATAP	-0.688123463760265	3.52112021455275e-11		NA	NA	NA
hsa-miR-200c-3p	NR2F2	6.44310729207051	0.0482567211582212	-3.51488704233982	0.0308566659520862	miRNATAP	-0.18300083789705	0.00551217949930412		NA	NA	NA
hsa-miR-200c-3p	NR5A2	6.44310729207051	0.0482567211582212	-3.71450877301349	5.18286290039655e-06	miRNATAP	-0.293213057510647	6.2876277671e-06		NA	NA	NA
hsa-miR-200c-3p	NRIP1	6.44310729207051	0.0482567211582212	0.24890109015702	0.860475031377604	MirTarget;miRNATAP	-0.10816109965001	0.0199729851728971		NA	NA	NA
hsa-miR-200c-3p	NTF3	6.44310729207051	0.0482567211582212	-3.57202740107989	0.00707319082213258	miRNAWalker2_validate;miRNATAP	-0.267305642123698	0.0128591951961541		NA	NA	NA
hsa-miR-200c-3p	NTRK2	6.44310729207051	0.0482567211582212	-1.16120587403287	0.515007480907086	miRNAWalker2_validate;miRTarBase	-0.454168801324507	0.00376453070732347	23209748;23074172	miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis	;drug resistance	breast cancer;ovarian cancer
hsa-miR-200c-3p	OSR1	6.44310729207051	0.0482567211582212	-3.86599765764029	0.00122160741903772	miRNATAP	-0.224486579018349	0.0278001675181878		NA	NA	NA
hsa-miR-200c-3p	OSTM1	6.44310729207051	0.0482567211582212	-0.979282633542716	0.391526258505954	MirTarget	-0.144381606754637	1.198982675558e-06		NA	NA	NA
hsa-miR-200c-3p	PALM2-AKAP2	6.44310729207051	0.0482567211582212	-3.08604310663124	0.0110238714958075	miRNATAP	-0.305842896114956	4.32607367167947e-08		NA	NA	NA
hsa-miR-200c-3p	PAM	6.44310729207051	0.0482567211582212	-2.22384395506325	0.224351635716404	miRNATAP	-0.14437512345728	0.00213670660943815		NA	NA	NA
hsa-miR-200c-3p	PCDH10	6.44310729207051	0.0482567211582212	-3.99701147286586	0.0105031933215657	MirTarget	-0.410999079753371	0.000240004532448457		NA	NA	NA
hsa-miR-200c-3p	PCDH8	6.44310729207051	0.0482567211582212	-1.80241745734445	0.381377803018098	miRNATAP	-0.481458307755227	0.000876420044990663		NA	NA	NA
hsa-miR-200c-3p	PCSK2	6.44310729207051	0.0482567211582212	-5.075232274683	0.00497446212690878	miRNATAP	-0.373089250480723	0.00171146815001149		NA	NA	NA
hsa-miR-200c-3p	PDE5A	6.44310729207051	0.0482567211582212	-2.54937482469107	0.0280264992975346	miRNATAP	-0.127332734914728	0.0365372802959883		NA	NA	NA
hsa-miR-200c-3p	PDE7B	6.44310729207051	0.0482567211582212	-4.3741973244199	1.62590497611775e-07	miRNATAP	-0.399850828912745	5.10690424888699e-09		NA	NA	NA
hsa-miR-200c-3p	PHACTR2	6.44310729207051	0.0482567211582212	-1.2714673791555	0.303740770104581	MirTarget;miRNATAP	-0.11831560677707	0.0024499121729224		NA	NA	NA
hsa-miR-200c-3p	PHEX	6.44310729207051	0.0482567211582212	-0.685769851650329	0.582294587585492	MirTarget	-0.25717822870116	0.0087890860685634		NA	NA	NA
hsa-miR-200c-3p	PHF21B	6.44310729207051	0.0482567211582212	-5.1833819291196	0.000152229867451558	MirTarget	-0.43353705324965	0.000113802315046582		NA	NA	NA
hsa-miR-200c-3p	PHLDB1	6.44310729207051	0.0482567211582212	-2.33620878957758	0.120158539658468	MirTarget;miRNATAP	-0.184663998295304	0.000452798835540723		NA	NA	NA
hsa-miR-200c-3p	PLCL1	6.44310729207051	0.0482567211582212	-4.15855328804462	2.8646979990244e-08	MirTarget	-0.497191096741011	4.83484210319897e-15		NA	NA	NA
hsa-miR-200c-3p	PLK2	6.44310729207051	0.0482567211582212	-0.165012808408171	0.907954428536636	miRNATAP	-0.180778621931832	0.0111658865295401		NA	NA	NA
hsa-miR-200c-3p	PLXNA4	6.44310729207051	0.0482567211582212	-4.15899789450024	0.000409468863699991	miRNATAP	-0.414126746697103	4.6232387427979e-05		NA	NA	NA
hsa-miR-200c-3p	PLXNC1	6.44310729207051	0.0482567211582212	-0.576670364446784	0.620340470714626	miRNATAP	-0.410325846976838	3.41260168180489e-05		NA	NA	NA
hsa-miR-200c-3p	PPM1F	6.44310729207051	0.0482567211582212	-1.09110235586082	0.354326670668235	miRNAWalker2_validate;MirTarget;miRNATAP	-0.217495124057734	4.38139349340462e-10	22144583	MicroRNA 200c represses migration and invasion of breast cancer cells by targeting actin regulatory proteins FHOD1 and PPM1F; We identified FHOD1 and PPM1F direct regulators of the actin cytoskeleton as novel targets of miR-200c; Remarkably expression levels of FHOD1 and PPM1F were inversely correlated with the level of miR-200c in breast cancer cell lines breast cancer patient samples and 58 cancer cell lines of various origins		breast cancer
hsa-miR-200c-3p	PPP2R2C	6.44310729207051	0.0482567211582212	-2.14970441894246	0.210302815670326	miRNATAP	-0.449989786928302	0.00282829298525296		NA	NA	NA
hsa-miR-200c-3p	PRDM1	6.44310729207051	0.0482567211582212	0.312871554588676	0.777121439024955	miRNATAP	-0.111957378771612	0.0464423792788125		NA	NA	NA
hsa-miR-200c-3p	PRKACB	6.44310729207051	0.0482567211582212	-1.43102246091501	0.224302971547832	MirTarget;miRNATAP	-0.145130591541329	0.00181365494045828		NA	NA	NA
hsa-miR-200c-3p	PRKAR2B	6.44310729207051	0.0482567211582212	-2.80949804746439	0.00824186817866949	miRNATAP	-0.232410940316261	0.00356398855766406		NA	NA	NA
hsa-miR-200c-3p	PRKCA	6.44310729207051	0.0482567211582212	-2.70939199323931	0.0466975830024901	miRNATAP	-0.227644911192639	0.000134967313056447		NA	NA	NA
hsa-miR-200c-3p	PRKCB	6.44310729207051	0.0482567211582212	-1.27852944454343	0.184280567208117	MirTarget;miRNATAP	-0.348745791831867	4.59454351785762e-06		NA	NA	NA
hsa-miR-200c-3p	PRKG1	6.44310729207051	0.0482567211582212	-4.24702684719048	0.000473938099582743	miRNATAP	-0.60078601717453	7.15419754813599e-10		NA	NA	NA
hsa-miR-200c-3p	PRTG	6.44310729207051	0.0482567211582212	-4.92194219404244	5.55440590865805e-05	miRNATAP	-0.492626275884265	9.734227497189e-07		NA	NA	NA
hsa-miR-200c-3p	PSD3	6.44310729207051	0.0482567211582212	-0.631558160090656	0.61052850074852	MirTarget;miRNATAP	-0.179645280009827	0.00370906342563686		NA	NA	NA
hsa-miR-200c-3p	PTPN13	6.44310729207051	0.0482567211582212	0.588348451288237	0.673457170832136	miRNAWalker2_validate;miRTarBase	-0.157780087828871	0.037667455919745		NA	NA	NA
hsa-miR-200c-3p	PTPN21	6.44310729207051	0.0482567211582212	-1.42106916457383	0.19107456597673	miRNATAP	-0.118289246395182	0.00191504152753466		NA	NA	NA
hsa-miR-200c-3p	PTPRD	6.44310729207051	0.0482567211582212	-5.58984062412554	0.000109443549183627	miRNAWalker2_validate	-0.635354452318971	2.46190452346783e-07		NA	NA	NA
hsa-miR-200c-3p	RAB11FIP2	6.44310729207051	0.0482567211582212	-2.43242195941095	0.00931530006020529	MirTarget;miRNATAP	-0.172798485882263	2.74230270085168e-08		NA	NA	NA
hsa-miR-200c-3p	RAB8B	6.44310729207051	0.0482567211582212	-1.13851632779934	0.281821359003741	miRNATAP	-0.159269333832142	5.51207964557748e-07		NA	NA	NA
hsa-miR-200c-3p	RAP2C	6.44310729207051	0.0482567211582212	-0.895391734777341	0.489996924846462	MirTarget;miRNATAP	-0.155545642776566	1.07715117890767e-06		NA	NA	NA
hsa-miR-200c-3p	RASSF2	6.44310729207051	0.0482567211582212	-1.88540702834194	0.0927929383475591	miRNAWalker2_validate	-0.328761284266132	3.24608790353016e-09		NA	NA	NA
hsa-miR-200c-3p	RASSF8	6.44310729207051	0.0482567211582212	-3.16818876391636	0.0041886046178264	miRNATAP	-0.146330480422942	0.0399611001191934		NA	NA	NA
hsa-miR-200c-3p	RBM20	6.44310729207051	0.0482567211582212	-2.08818568133697	0.0956304093909354	MirTarget	-0.238594838707177	0.0221061153744374		NA	NA	NA
hsa-miR-200c-3p	RECK	6.44310729207051	0.0482567211582212	-4.22025906667793	5.62448088064888e-07	miRNATAP	-0.536671939774126	3.22939236580011e-16	27574450;24647918	MiR 200c promotes bladder cancer cell migration and invasion by directly targeting RECK; The luciferase reporter assay showed that RECK was a direct target of miR-200c;Finally we demonstrated that expression of miR-200c in H460 cells suppressed cell growth by targeting RECK followed by activation of the JNK signaling pathway and ER stress; Collectively these data show that miR-200c expression sensitizes H460 cells to RESV and this is likely due to RECK expression	cell migration;	bladder cancer;lung cancer
hsa-miR-200c-3p	RELN	6.44310729207051	0.0482567211582212	-4.79522839957135	0.000734989259451473	MirTarget	-0.467982105834413	0.000116086212043485		NA	NA	NA
hsa-miR-200c-3p	RFTN2	6.44310729207051	0.0482567211582212	-2.98860479294138	3.86590341288018e-06	MirTarget	-0.273199280087174	3.60266549875008e-07		NA	NA	NA
hsa-miR-200c-3p	RGL1	6.44310729207051	0.0482567211582212	-2.11199072379308	0.0443530773291477	MirTarget;miRNATAP	-0.266088067783328	1.18774605161995e-07		NA	NA	NA
hsa-miR-200c-3p	RIN2	6.44310729207051	0.0482567211582212	-0.192774538245745	0.892797852961463	miRNAWalker2_validate	-0.120781816392807	0.00167875088084308		NA	NA	NA
hsa-miR-200c-3p	RNF38	6.44310729207051	0.0482567211582212	-1.25524687211555	0.308856989219259	MirTarget;miRNATAP	-0.109244794425757	4.71288657514708e-05		NA	NA	NA
hsa-miR-200c-3p	RPS6KA2	6.44310729207051	0.0482567211582212	-2.78044980661611	0.0445053977647349	miRNATAP	-0.185226101150327	0.005371700638205		NA	NA	NA
hsa-miR-200c-3p	RUSC2	6.44310729207051	0.0482567211582212	-2.35121856069337	0.0437192308469714	miRNATAP	-0.172975788829819	2.64011161796328e-05		NA	NA	NA
hsa-miR-200c-3p	SASH1	6.44310729207051	0.0482567211582212	-1.00586032844365	0.433786231473321	MirTarget	-0.103547128326134	0.0250528217783149		NA	NA	NA
hsa-miR-200c-3p	SCN2A	6.44310729207051	0.0482567211582212	-1.37481154644645	0.463812422709766	MirTarget;miRNATAP	-0.362316939864991	0.0219963858357387		NA	NA	NA
hsa-miR-200c-3p	SCN5A	6.44310729207051	0.0482567211582212	-2.53789478300071	0.0226578670202977	miRNATAP	-0.26133629689935	0.00373590019450882		NA	NA	NA
hsa-miR-200c-3p	SDC2	6.44310729207051	0.0482567211582212	-3.55722756060255	0.0113102383373118	miRNATAP	-0.350366467118006	1.04074763024558e-05		NA	NA	NA
hsa-miR-200c-3p	SEC23A	6.44310729207051	0.0482567211582212	-1.07753939086866	0.425948248584201	MirTarget;miRNATAP	-0.155899677760209	9.61657475797632e-07	21593139	A computational analysis predicted the 3'-UTR of the SEC23A gene as a potential target for both miR-375 and miR-200c; Here we show that the 3'-UTR of SEC23A mRNA is indeed a target for miR-375 and miR-200c and that both miRNAs downregulate Sec23A protein expression when ectopically expressed in human 293T cells; In primary samples of CaP we found a direct correlation between reduction of SEC23A mRNA and overexpression of miR-375 but not of miR-200c		prostate cancer
hsa-miR-200c-3p	SEMA6D	6.44310729207051	0.0482567211582212	-1.98500480537177	0.117871830802107	miRNATAP	-0.318278406212089	0.00373481127298918		NA	NA	NA
hsa-miR-200c-3p	SEPT7	6.44310729207051	0.0482567211582212	-0.864084722381038	0.603782137070473	miRNAWalker2_validate	-0.101190664212694	5.21354197876974e-06		NA	NA	NA
hsa-miR-200c-3p	SERINC1	6.44310729207051	0.0482567211582212	-1.80427380410435	0.291344660096508	MirTarget;miRNATAP	-0.103316287900782	0.000123941961070085		NA	NA	NA
hsa-miR-200c-3p	SESN1	6.44310729207051	0.0482567211582212	-1.72450656181121	0.105705089905641	MirTarget;miRNATAP	-0.112372276298621	0.00331320290805762	24791940	We found that miR-200c overexpression increased cellular radiosensitivity by direct regulation of the oxidative stress response genes PRDX2 GAPB/Nrf2 and SESN1 in ways that inhibits DNA double-strand breaks repair increase levels of reactive oxygen species and upregulate p21	drug resistance	lung cancer
hsa-miR-200c-3p	SESN3	6.44310729207051	0.0482567211582212	-0.10502647433173	0.909984852408186	MirTarget	-0.222251723022918	0.00801686722592441		NA	NA	NA
hsa-miR-200c-3p	SGIP1	6.44310729207051	0.0482567211582212	-2.21433213315124	0.00849096905479303	MirTarget	-0.3895640785862	1.4943288496287e-08		NA	NA	NA
hsa-miR-200c-3p	SGPP1	6.44310729207051	0.0482567211582212	-0.909857418535486	0.410916396656922	MirTarget	-0.141617727006824	0.0359212305000563		NA	NA	NA
hsa-miR-200c-3p	SHC1	6.44310729207051	0.0482567211582212	0.013077514456274	0.993731444270879	miRNAWalker2_validate;miRNATAP	-0.11196651448805	0.00101570662036496		NA	NA	NA
hsa-miR-200c-3p	SIRPA	6.44310729207051	0.0482567211582212	-0.00916174027588745	0.994303981836023	MirTarget	-0.227251060736523	0.000269469610375052		NA	NA	NA
hsa-miR-200c-3p	SLC14A1	6.44310729207051	0.0482567211582212	-2.37039680226772	0.0415839944551325	miRNATAP	-0.235455107164791	0.0204564330988927		NA	NA	NA
hsa-miR-200c-3p	SLC16A2	6.44310729207051	0.0482567211582212	-2.26276891772423	0.0298329176243689	miRNATAP	-0.476186910895051	3.16592313947576e-08		NA	NA	NA
hsa-miR-200c-3p	SLC23A2	6.44310729207051	0.0482567211582212	-0.895012846783366	0.459978750894018	miRNATAP	-0.122792951402979	0.00100323010234348		NA	NA	NA
hsa-miR-200c-3p	SLC35B4	6.44310729207051	0.0482567211582212	-0.538503063075182	0.582044591876548	MirTarget	-0.131257885360482	2.75496707690194e-06		NA	NA	NA
hsa-miR-200c-3p	SLC38A4	6.44310729207051	0.0482567211582212	-1.8097833242263	0.232417439593608	miRNATAP	-0.54123427052395	8.8422888836581e-06		NA	NA	NA
hsa-miR-200c-3p	SLC6A1	6.44310729207051	0.0482567211582212	-3.02435257479891	0.00374380337215481	MirTarget;miRNATAP	-0.440288717648609	3.58903270906144e-09		NA	NA	NA
hsa-miR-200c-3p	SNAI2	6.44310729207051	0.0482567211582212	-1.02584401122761	0.271071580756427	miRNATAP	-0.366231228387546	0.000154734539121361		NA	NA	NA
hsa-miR-200c-3p	SNAP25	6.44310729207051	0.0482567211582212	-4.17840044090383	0.00254500342991685	MirTarget;miRNATAP	-0.354062506410651	0.00238187873896826		NA	NA	NA
hsa-miR-200c-3p	SPRED1	6.44310729207051	0.0482567211582212	-1.25861751555157	0.320744800979621	miRNATAP	-0.151820076292416	2.37878276088673e-05		NA	NA	NA
hsa-miR-200c-3p	ST3GAL2	6.44310729207051	0.0482567211582212	-1.8673907596323	0.0788357050341252	MirTarget;miRNATAP	-0.216701199628863	1.81964890021464e-09		NA	NA	NA
hsa-miR-200c-3p	SULF1	6.44310729207051	0.0482567211582212	-1.18930543974369	0.466392747934695	MirTarget;miRNATAP	-0.360488305548038	1.09842699234066e-05		NA	NA	NA
hsa-miR-200c-3p	SYDE1	6.44310729207051	0.0482567211582212	-2.57581772371894	0.0121491721740433	MirTarget;miRNATAP	-0.33750733799032	1.10556010223901e-06		NA	NA	NA
hsa-miR-200c-3p	SYNC	6.44310729207051	0.0482567211582212	-2.24548270961013	0.111119347483887	MirTarget	-0.288661481387845	0.0070112376600782		NA	NA	NA
hsa-miR-200c-3p	SYT1	6.44310729207051	0.0482567211582212	-4.9979883905504	0.00227814853668419	MirTarget;miRNATAP	-0.344569585272886	0.0128067567180787		NA	NA	NA
hsa-miR-200c-3p	TBX18	6.44310729207051	0.0482567211582212	-1.70567413195557	0.420444910786116	MirTarget	-0.412320828282902	0.02066773595821		NA	NA	NA
hsa-miR-200c-3p	TCF4	6.44310729207051	0.0482567211582212	-2.16917898839348	0.105758965590781	miRNATAP	-0.25143745636959	4.36153655385987e-05		NA	NA	NA
hsa-miR-200c-3p	TCP11L1	6.44310729207051	0.0482567211582212	-0.195438750549478	0.804340077428867	MirTarget	-0.107640384613073	0.0112041109554204		NA	NA	NA
hsa-miR-200c-3p	TFEC	6.44310729207051	0.0482567211582212	1.48655557453868	0.0846031561210134	MirTarget	-0.245108964025473	0.00133548298273867		NA	NA	NA
hsa-miR-200c-3p	TFPI	6.44310729207051	0.0482567211582212	-2.98540839705942	0.0248914684767339	MirTarget	-0.215777673306079	0.0240549902876771		NA	NA	NA
hsa-miR-200c-3p	TIMP2	6.44310729207051	0.0482567211582212	-3.66967954912634	0.0556506707959173	miRTarBase	-0.407824446555903	3.01880203041024e-12		NA	NA	NA
hsa-miR-200c-3p	TLN1	6.44310729207051	0.0482567211582212	-1.66474324734484	0.380472539130071	miRNATAP	-0.184119439610688	6.81566389819943e-12		NA	NA	NA
hsa-miR-200c-3p	TLN2	6.44310729207051	0.0482567211582212	-1.64316647929482	0.196356768962796	miRNATAP	-0.136336028166196	0.0273891480236767		NA	NA	NA
hsa-miR-200c-3p	TMEM43	6.44310729207051	0.0482567211582212	-1.25087877474337	0.419379792438811	MirTarget	-0.152920322721576	4.49861698325332e-07		NA	NA	NA
hsa-miR-200c-3p	TRAM1L1	6.44310729207051	0.0482567211582212	-3.67031323921676	0.00173312860324242	MirTarget;miRNATAP	-0.349873012293866	0.000374939693579546		NA	NA	NA
hsa-miR-200c-3p	TRHDE	6.44310729207051	0.0482567211582212	-5.440533212701	0.00109890436959175	MirTarget	-0.649760772399373	6.47732689225381e-07		NA	NA	NA
hsa-miR-200c-3p	TRIL	6.44310729207051	0.0482567211582212	-1.96710195319349	0.106785262977764	MirTarget	-0.41608331302924	2.60594849492216e-05		NA	NA	NA
hsa-miR-200c-3p	VASH1	6.44310729207051	0.0482567211582212	-0.894193078380903	0.415969648098732	MirTarget;miRNATAP	-0.253443755810345	4.26019022502806e-08		NA	NA	NA
hsa-miR-200c-3p	VAT1L	6.44310729207051	0.0482567211582212	-3.22025751762841	0.0130087299241357	MirTarget;miRNATAP	-0.486096476957685	8.0103781622939e-07		NA	NA	NA
hsa-miR-200c-3p	WASF3	6.44310729207051	0.0482567211582212	-2.72988228233946	0.0165070769730743	miRNATAP	-0.419645019455589	9.18056415535885e-06		NA	NA	NA
hsa-miR-200c-3p	WDR91	6.44310729207051	0.0482567211582212	0.988859402218083	0.385573962577763	MirTarget	-0.107533271819569	0.0300925575769533		NA	NA	NA
hsa-miR-200c-3p	WIPF1	6.44310729207051	0.0482567211582212	-1.22265225716919	0.338259180670603	MirTarget;miRNATAP	-0.270239604564852	1.57518771534792e-06		NA	NA	NA
hsa-miR-200c-3p	XKR6	6.44310729207051	0.0482567211582212	0.347305380726526	0.783131473506836	miRNATAP	-0.306177625628666	0.00160486748808227		NA	NA	NA
hsa-miR-200c-3p	YAP1	6.44310729207051	0.0482567211582212	-0.627891668173223	0.723771353015186	MirTarget	-0.138813416618053	0.0389104444590292		NA	NA	NA
hsa-miR-200c-3p	ZC3H6	6.44310729207051	0.0482567211582212	-1.40888365206518	0.0954295897822841	MirTarget;miRNATAP	-0.110298435957103	0.00331750488395284		NA	NA	NA
hsa-miR-200c-3p	ZCCHC24	6.44310729207051	0.0482567211582212	-4.232799645244	2.91943319846833e-05	MirTarget;miRNATAP	-0.450120821010846	1.34321524927686e-20		NA	NA	NA
hsa-miR-200c-3p	ZDHHC15	6.44310729207051	0.0482567211582212	-5.03016207364914	0.000595578125505624	MirTarget	-0.482200261962873	5.83026879096635e-05		NA	NA	NA
hsa-miR-200c-3p	ZEB1	6.44310729207051	0.0482567211582212	-4.178776434472	5.14390995559402e-05	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.480321526877672	3.14204853907128e-17	27666124;24710933;23754305;24615544;24424572;24186205;21682933;22407310;27717206;23626803	miR 200c regulates crizotinib resistant ALK positive lung cancer cells by reversing epithelial mesenchymal transition via targeting ZEB1;miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;Overexpression of miR-200c in SN12-PM6 and 786-0 cells was concurrent with downregulation of ZEB1 and upregulation of E-cadherin mRNA and protein; Thus our study demonstrated that miR-200c decreases the metastatic ability of renal carcinoma cells by upregulating E-cadherin through ZEB1 and that modulating the expression of miR-200c could influence Akt protein levels;MiR 200c suppresses TGF β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer; MiR-200c which was the most significantly downregulated miRNA in trastuzumab-resistant cells restored trastuzumab sensitivity and suppressed invasion of breast cancer cells by concurrently targeting ZNF217 a transcriptional activator of TGF-β and ZEB1 a known mediator of TGF-β signaling; Given the reported backward inhibition of miR-200c by ZEB1 ZNF217 also exerts a feedback suppression of miR-200c via TGF-β/ZEB1 signaling; Restoration of miR-200c silencing of ZEB1 or ZNF217 or blockade of TGF-β signaling increased trastuzumab sensitivity and suppressed invasiveness of breast cancer cells;Accordingly the enforced expression of miR-200c and mir-141 resulted in a significant upregulation in E-cadherin expression contrary to the significant downregulation in ZEB1 expression in 3 cell lines UTSCC-24A UTSCC-24B and UTSCC-6A cells;Furthermore miR-200c was found to be important in modulating ZEB1 upregulation by ERG;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;miR 200c inhibits invasion and migration in human colon cancer cells SW480/620 by targeting ZEB1; Among those dysregulated microRNAs miR-200c was speculated to inhibit metastasis by targeting ZEB1; Overexpression of miR-200c was concurrent with downregulation of ZEB1 mRNA and protein; Taken together our study demonstrated that miR-200c inhibits metastatic ability by targeting ZEB1 in colon cancer cells SW480/620 and suggested that modulation of miR-200c could serve as therapeutic tool for inhibiting metastasis in colorectal cancer;Epigenetic Silencing of miR 200c in Breast Cancer Is Associated with Aggressiveness and Is Modulated by ZEB1;Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition	;metastasis;;metastasis;drug resistance;;;;metastasis;;	lung cancer;breast cancer;kidney renal cell cancer;breast cancer;head and neck cancer;prostate cancer;breast cancer;colon cancer;breast cancer;breast cancer
hsa-miR-200c-3p	ZEB2	6.44310729207051	0.0482567211582212	-2.37903880179133	0.00922460764014952	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.432652376485522	5.29696777085928e-18	24710933;26935975;21682933;25052237;18925646;24885194	miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;MicroRNA 200c inhibits the metastasis of non small cell lung cancer cells by targeting ZEB2 an epithelial mesenchymal transition regulator;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;miR 200c modulates ovarian cancer cell metastasis potential by targeting zinc finger E box binding homeobox 2 ZEB2 expression; Luciferase reporter assay confirmed the target of miR-200c as ZEB2; Furthermore miR-200c expression inhibited ovarian cancer cell ES-2 migration and invasion capacity by suppression of ZEB2 expression p < 0.01; Thus targeting of miR-200c or ZEB2 may serve as a potential therapeutic strategy for control of ovarian cancer;We established by quantitative RT-PCR that in CCCs in which miR-141 and miR-200c were down-regulated ZFHX1B a transcriptional repressor for CDH1/E-cadherin tended to be up-regulated; On the basis of these findings we suggest that down-regulation of miR-141 and miR-200c in CCCs might be involved in suppression of CDH1/E-cadherin transcription via up-regulation of ZFHX1B;Two gastric cancer cell lines were treated with IGF-I to induce EMT and levels of transcription factor ZEB2 and microRNA-200c miR-200c were measured; Furthermore both Akt/ERK inhibitors and knockdown of Akt/ERK gene reversed IGF-I-induced ZEB2 up-regulation and EMT through up-regulation of miR-200c suggesting the involvement of an Akt/ERK-miR-200c-ZEB2 axis in IGF-I-induced EMT	metastasis;metastasis;;metastasis;;	breast cancer;lung squamous cell cancer;breast cancer;ovarian cancer;kidney renal cell cancer;gastric cancer
hsa-miR-200c-3p	ZFHX4	6.44310729207051	0.0482567211582212	-3.2638506757484	0.016210300922743	miRNATAP	-0.487540868543922	2.3495154787838e-05		NA	NA	NA
hsa-miR-200c-3p	ZFPM2	6.44310729207051	0.0482567211582212	-5.0871378945091	2.46286403227162e-05	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.459353569317028	8.95829339403547e-06		NA	NA	NA
hsa-miR-200c-3p	ZNF423	6.44310729207051	0.0482567211582212	-4.62452801956953	2.92300329012354e-06	MirTarget	-0.454565123100415	4.77817606270741e-08		NA	NA	NA
hsa-miR-200c-3p	ZNF516	6.44310729207051	0.0482567211582212	-2.4275023878898	0.0251315335794902	miRNATAP	-0.121290659459521	0.0318743283873794		NA	NA	NA
hsa-miR-200c-3p	ZNF532	6.44310729207051	0.0482567211582212	-0.483701140383291	0.722712342035945	MirTarget;miRNATAP	-0.152166841555222	0.000243551639900262		NA	NA	NA