miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-101-3p AKT3 0.522819989585461 0.00375627731618038 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.334857831597034 0.000597756240419548 NA NA NA hsa-miR-106a-5p AKT3 2.48882002962836 1.99757727374521e-12 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.236478824223264 6.56988295029948e-07 NA NA NA hsa-miR-106b-5p AKT3 2.46782146831112 1.36171495805632e-23 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.521755012930227 1.0756262414999e-15 NA NA NA hsa-miR-107 AKT3 1.30977326593435 1.30372468603965e-11 -1.94162990884529 4.54380296394505e-08 PITA;miRanda -0.438321009170574 6.41595199298462e-07 NA NA NA hsa-miR-15a-5p AKT3 2.34669284378787 1.69544424500258e-23 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.653282073492048 2.38693369892811e-22 NA NA NA hsa-miR-15b-5p AKT3 1.57112623124278 9.14247846750597e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.4862313443712 1.80429141906685e-10 NA NA NA hsa-miR-16-5p AKT3 1.75824877145857 1.68592440033108e-16 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.527819854451446 1.06852141480407e-11 NA NA NA hsa-miR-17-3p AKT3 2.2704817679209 1.1667437320211e-22 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.393678889428456 2.72155279297878e-08 NA NA NA hsa-miR-17-5p AKT3 3.2710598467455 9.93128340539455e-27 -1.94162990884529 4.54380296394505e-08 TargetScan;miRNATAP -0.385876321416217 1.42856705542315e-13 NA NA NA hsa-miR-181a-5p AKT3 2.29556023480783 1.8138457900616e-21 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.283343247743329 3.77571043690309e-05 NA NA NA hsa-miR-181b-5p AKT3 2.49307679431293 3.92829250217627e-20 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.273550202394616 7.65012329836386e-06 NA NA NA hsa-miR-181c-5p AKT3 1.58587920618301 1.57506918816933e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.234902996176996 0.000670085449584041 NA NA NA hsa-miR-20a-5p AKT3 3.15577933619191 4.19753346442454e-25 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.397380097014522 3.56434655429537e-14 NA NA NA hsa-miR-20b-5p AKT3 2.07706563022469 1.10107236083433e-05 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.159136097484426 1.15057100055016e-05 NA NA NA hsa-miR-22-3p AKT3 1.21545661147757 1.61670170137775e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.356198759053997 0.000637369773108939 NA NA NA hsa-miR-29b-2-5p AKT3 0.910668640983475 0.00666655585493488 -1.94162990884529 4.54380296394505e-08 mirMAP -0.413342005890553 1.74596670459023e-16 NA NA NA hsa-miR-29b-3p AKT3 1.65828197923813 1.02676780888141e-09 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.328715384299769 1.41956551647306e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.00968972577705429 0.97099586346872 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRNATAP -0.256484648428124 9.16722320814547e-05 NA NA NA hsa-miR-3065-5p AKT3 2.74629919868982 1.86846589298284e-08 -1.94162990884529 4.54380296394505e-08 mirMAP -0.196776388311872 4.09483787014971e-06 NA NA NA hsa-miR-32-3p AKT3 2.02436999565685 5.94091197945307e-09 -1.94162990884529 4.54380296394505e-08 mirMAP -0.274043726011417 8.75730973684685e-07 NA NA NA hsa-miR-320a AKT3 0.438165828017084 0.0390159073347133 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.539139659729602 3.01448987258332e-11 NA NA NA hsa-miR-320b AKT3 1.55692969039548 1.41071034251915e-08 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.376164976249955 1.04134326075959e-09 NA NA NA hsa-miR-335-3p AKT3 3.08791651139852 5.31309869723517e-12 -1.94162990884529 4.54380296394505e-08 mirMAP -0.222130607012057 2.63416728864213e-09 NA NA NA hsa-miR-33a-3p AKT3 1.72765312072219 1.51784443453521e-07 -1.94162990884529 4.54380296394505e-08 mirMAP -0.325733544419159 9.28241682908522e-09 NA NA NA hsa-miR-362-3p AKT3 2.0756816987665 3.89026064579331e-12 -1.94162990884529 4.54380296394505e-08 miRanda -0.16536843343699 0.0049777492806053 NA NA NA hsa-miR-362-5p AKT3 1.59303749908759 9.582675908797e-08 -1.94162990884529 4.54380296394505e-08 PITA;TargetScan;miRNATAP -0.201169258976553 0.000472996311050305 NA NA NA hsa-miR-374a-5p AKT3 0.484615721953736 0.0042981729815149 -1.94162990884529 4.54380296394505e-08 mirMAP -0.289501808595266 0.00547104114009117 NA NA NA hsa-miR-421 AKT3 1.17791565395543 6.78526676976629e-06 -1.94162990884529 4.54380296394505e-08 miRanda;mirMAP -0.270003673244585 4.40560995362011e-05 NA NA NA hsa-miR-501-3p AKT3 1.83132758513743 1.10971547702065e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.357094776714992 1.69773165528929e-09 NA NA NA hsa-miR-502-3p AKT3 1.50560877085049 1.2647489756373e-11 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.326505295822604 2.04961437337709e-05 NA NA NA hsa-miR-505-3p AKT3 1.45322244209148 8.86597629645867e-10 -1.94162990884529 4.54380296394505e-08 mirMAP -0.409352554521824 1.03207996907079e-08 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-769-5p AKT3 1.82023760596845 9.6815886564134e-14 -1.94162990884529 4.54380296394505e-08 PITA;miRNATAP -0.445071301297515 6.71512496875401e-11 NA NA NA hsa-miR-93-5p AKT3 3.03961860136032 1.11672209617395e-24 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.494281511913237 1.38435165024812e-20 NA NA NA hsa-miR-199a-3p CASP9 0.640600337515787 0.0380326905134914 -0.446359927280876 0.00400976702291555 mirMAP -0.146082132838509 1.00313136531724e-09 23319430 The techniques used were the MTT assay flow cytometry real-time PCR to assess miR-199a expression as also caspase-8 and caspase-9 activity in HepG2 cells treated with Propofol liver cancer hsa-miR-199b-3p CASP9 0.643923492750702 0.0371742251925406 -0.446359927280876 0.00400976702291555 mirMAP -0.146136089499986 9.60609442207656e-10 NA NA NA hsa-miR-222-5p CASP9 1.25632771414778 0.000138653440511922 -0.446359927280876 0.00400976702291555 mirMAP -0.126831808191525 1.31064720813193e-08 NA NA NA hsa-miR-143-3p HRAS -2.5789192793377 1.55518999614836e-14 0.623195449314017 0.00175543589552248 miRNAWalker2_validate;miRTarBase -0.162589208332201 3.09270971499286e-09 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-15b-5p KDR 1.57112623124278 9.14247846750597e-13 -0.809645188569233 0.00140156336172476 miRNATAP -0.155621687078152 0.0045182683141369 NA NA NA hsa-miR-16-5p KDR 1.75824877145857 1.68592440033108e-16 -0.809645188569233 0.00140156336172476 miRTarBase;miRNATAP -0.182939670656605 0.00106812366151133 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-19b-1-5p KDR 2.57951428759379 4.31576118703427e-20 -0.809645188569233 0.00140156336172476 miRNAWalker2_validate -0.229520229616341 6.75997699685035e-08 NA NA NA hsa-miR-200c-3p KDR 3.50132673580082 2.42716349086937e-15 -0.809645188569233 0.00140156336172476 miRNATAP -0.100553706909197 0.000169957263481419 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-23a-3p KDR 1.00493340843378 2.55313889288924e-08 -0.809645188569233 0.00140156336172476 mirMAP -0.286683208573693 2.23043040222106e-05 NA NA NA hsa-miR-3065-3p KDR 2.16221780121195 9.65525739884541e-09 -0.809645188569233 0.00140156336172476 miRNATAP -0.115781865974172 0.00029357167187714 NA NA NA hsa-miR-455-5p KDR 2.2582442061694 1.43472128037398e-13 -0.809645188569233 0.00140156336172476 PITA;miRanda;miRNATAP -0.148297955432885 0.000143983958437006 NA NA NA hsa-miR-590-3p KDR 2.59289455139753 1.03200520972022e-21 -0.809645188569233 0.00140156336172476 miRanda -0.18919157083552 1.89718911518431e-05 NA NA NA hsa-miR-590-5p KDR 3.18300989862077 2.06813568597893e-26 -0.809645188569233 0.00140156336172476 miRanda -0.161280644562926 4.49661990812652e-05 NA NA NA hsa-miR-101-3p MAP2K1 0.522819989585461 0.00375627731618038 0.329146605656592 0.0110879553061078 miRNAWalker2_validate -0.179174585612232 2.32589570104786e-07 NA NA NA hsa-miR-30c-5p MAP2K1 0.778774633108 0.000285599212429136 0.329146605656592 0.0110879553061078 miRNAWalker2_validate -0.1435696131991 6.86626187272449e-07 NA NA NA hsa-miR-140-3p MAPK1 0.0608890720479334 0.727716871248724 -0.300413846088826 0.0202503240217449 PITA;miRNATAP -0.126850675206772 0.000457308593536618 NA NA NA hsa-miR-30c-5p MAPK1 0.778774633108 0.000285599212429136 -0.300413846088826 0.0202503240217449 mirMAP -0.161696427374548 1.83237959021178e-08 NA NA NA hsa-miR-30e-5p MAPK1 1.23904909539663 1.35561917122157e-09 -0.300413846088826 0.0202503240217449 mirMAP -0.123981973754552 3.68994437193015e-05 NA NA NA hsa-miR-34a-5p MAPK1 1.9016323452565 1.43092834643601e-14 -0.300413846088826 0.0202503240217449 mirMAP -0.113934200811126 2.89029232507908e-06 NA NA NA hsa-let-7a-5p MAPK11 0.618599506841644 2.76973453058748e-05 -0.196415230656332 0.448327489263399 miRNAWalker2_validate -0.307003566466655 0.000342197753908208 NA NA NA hsa-miR-125a-5p MAPK12 0.599529391575274 0.0102300147180307 0.275993547616267 0.337663040254231 miRNATAP -0.20965473468004 0.000440693435433499 NA NA NA hsa-miR-125a-5p MAPK14 0.599529391575274 0.0102300147180307 -0.303640775567793 0.00978869421579312 PITA;miRanda;miRNATAP -0.124626568360645 2.34301936142697e-07 NA NA NA hsa-miR-128-3p MAPK14 1.63756041666078 6.79626586407187e-14 -0.303640775567793 0.00978869421579312 MirTarget -0.123697475515887 8.13597348141631e-07 NA NA NA hsa-miR-185-5p MAPK14 2.34016206907488 1.17481626642022e-26 -0.303640775567793 0.00978869421579312 miRNATAP -0.102052885005283 2.68112109007415e-05 NA NA NA hsa-miR-186-5p MAPK14 1.47445398888668 3.0781726595413e-15 -0.303640775567793 0.00978869421579312 mirMAP -0.145764601926808 6.78661707873898e-07 NA NA NA hsa-miR-320a MAPK14 0.438165828017084 0.0390159073347133 -0.303640775567793 0.00978869421579312 PITA;miRanda -0.141203542311255 1.09004547156543e-07 NA NA NA hsa-miR-361-5p MAPK14 0.971859117235239 5.30236555707088e-09 -0.303640775567793 0.00978869421579312 miRanda -0.12419245062687 0.000245845933637211 NA NA NA hsa-miR-125a-5p MAPKAPK2 0.599529391575274 0.0102300147180307 -0.224125552106657 0.0644502467861093 MirTarget;mirMAP -0.101734713265786 4.60987327357687e-05 NA NA NA hsa-miR-324-3p MAPKAPK2 2.08739139768981 3.11885987067952e-13 -0.224125552106657 0.0644502467861093 MirTarget -0.111754881090397 1.08981200782298e-08 NA NA NA hsa-miR-146b-5p NFAT5 1.75587235896724 1.15724631266659e-07 -0.392833700410932 0.0377471321681522 miRanda -0.153971114303279 9.27272608710862e-09 NA NA NA hsa-miR-148a-3p NFAT5 1.26728238710376 2.52325607402829e-06 -0.392833700410932 0.0377471321681522 miRNATAP -0.102833049736599 0.0022445738911715 NA NA NA hsa-miR-155-5p NFAT5 1.20164021433135 0.00086170622431261 -0.392833700410932 0.0377471321681522 mirMAP;miRNATAP -0.132036023095404 1.17438455270541e-07 NA NA NA hsa-miR-15b-3p NFAT5 2.33847028227712 4.29662877950836e-19 -0.392833700410932 0.0377471321681522 mirMAP -0.105075014155593 0.00169123758741249 NA NA NA hsa-miR-15b-5p NFAT5 1.57112623124278 9.14247846750597e-13 -0.392833700410932 0.0377471321681522 MirTarget -0.142553701038326 0.000445429182940406 NA NA NA hsa-miR-17-3p NFAT5 2.2704817679209 1.1667437320211e-22 -0.392833700410932 0.0377471321681522 mirMAP -0.156781273910673 2.73481212608122e-05 NA NA NA hsa-miR-17-5p NFAT5 3.2710598467455 9.93128340539455e-27 -0.392833700410932 0.0377471321681522 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.130692587121015 2.70754809666796e-06 NA NA NA hsa-miR-186-5p NFAT5 1.47445398888668 3.0781726595413e-15 -0.392833700410932 0.0377471321681522 MirTarget;mirMAP -0.164781957469426 0.000548507264256057 NA NA NA hsa-miR-18a-5p NFAT5 3.78535678765353 3.72446596213886e-26 -0.392833700410932 0.0377471321681522 MirTarget;miRNATAP -0.131263409331572 1.65685429541776e-07 NA NA NA hsa-miR-193a-3p NFAT5 1.60460546928078 2.86169793322984e-07 -0.392833700410932 0.0377471321681522 miRanda -0.154805940441061 5.65348218966617e-08 NA NA NA hsa-miR-20a-5p NFAT5 3.15577933619191 4.19753346442454e-25 -0.392833700410932 0.0377471321681522 MirTarget;miRNATAP -0.130133275869658 3.48894650319326e-06 NA NA NA hsa-miR-21-3p NFAT5 2.19296355304364 4.63665722759779e-15 -0.392833700410932 0.0377471321681522 MirTarget -0.142374696456314 5.86977917811346e-06 NA NA NA hsa-miR-21-5p NFAT5 2.73773305747971 1.38864982139576e-43 -0.392833700410932 0.0377471321681522 miRNAWalker2_validate;mirMAP -0.137353463476768 0.0010230389162988 NA NA NA hsa-miR-25-3p NFAT5 1.36472605225697 4.83790725935681e-11 -0.392833700410932 0.0377471321681522 miRNATAP -0.160932569364308 0.000198217746469054 NA NA NA hsa-miR-29b-1-5p NFAT5 1.55384379072167 4.76870585070176e-05 -0.392833700410932 0.0377471321681522 MirTarget -0.108933017578416 1.32879285648522e-05 NA NA NA hsa-miR-338-5p NFAT5 -0.577691606146419 0.0472212680542825 -0.392833700410932 0.0377471321681522 MirTarget;PITA;mirMAP -0.125257085814405 7.29810204796898e-05 NA NA NA hsa-miR-340-5p NFAT5 0.30282999308409 0.157744789519131 -0.392833700410932 0.0377471321681522 MirTarget -0.151422565494268 0.000416794206059885 NA NA NA hsa-miR-361-3p NFAT5 1.07367425434318 1.73142774168958e-09 -0.392833700410932 0.0377471321681522 MirTarget;PITA;miRNATAP -0.183420224613813 0.000306310131071959 NA NA NA hsa-miR-362-5p NFAT5 1.59303749908759 9.582675908797e-08 -0.392833700410932 0.0377471321681522 mirMAP -0.15295196000171 3.09689810925579e-07 NA NA NA hsa-miR-365a-3p NFAT5 -0.0388985816963467 0.859114494267351 -0.392833700410932 0.0377471321681522 MirTarget -0.121321120716043 0.00395288593253482 NA NA NA hsa-miR-374a-3p NFAT5 0.533309330504947 0.00192918429705142 -0.392833700410932 0.0377471321681522 mirMAP -0.179441859225574 0.00082661585518594 NA NA NA hsa-miR-374b-5p NFAT5 0.0654362503857184 0.722673188879465 -0.392833700410932 0.0377471321681522 mirMAP;miRNATAP -0.138291681791848 0.00598798789718749 NA NA NA hsa-miR-500a-3p NFAT5 1.47161373123699 5.30571342631915e-09 -0.392833700410932 0.0377471321681522 MirTarget -0.194453706264052 3.59854094855025e-08 NA NA NA hsa-miR-500a-5p NFAT5 1.72110365584658 3.0807246212659e-10 -0.392833700410932 0.0377471321681522 mirMAP -0.137523536356053 2.56447700222189e-05 NA NA NA hsa-miR-511-5p NFAT5 1.04499312543772 0.00234126154508174 -0.392833700410932 0.0377471321681522 MirTarget -0.104679263781806 7.51885794085489e-05 NA NA NA hsa-miR-576-5p NFAT5 2.20467023993664 3.4053475193793e-19 -0.392833700410932 0.0377471321681522 MirTarget;PITA;mirMAP -0.125849037192384 0.000403381066087259 NA NA NA hsa-miR-589-3p NFAT5 2.51971841868825 2.39125940264107e-11 -0.392833700410932 0.0377471321681522 MirTarget -0.138187642380203 2.13896683508276e-07 NA NA NA hsa-miR-590-3p NFAT5 2.59289455139753 1.03200520972022e-21 -0.392833700410932 0.0377471321681522 MirTarget;miRanda;mirMAP;miRNATAP -0.112321248136072 0.000659914987197463 NA NA NA hsa-miR-590-5p NFAT5 3.18300989862077 2.06813568597893e-26 -0.392833700410932 0.0377471321681522 PITA;mirMAP;miRNATAP -0.113584598428477 0.000110657386354584 NA NA NA hsa-miR-7-1-3p NFAT5 1.84950311431067 1.25300363397654e-13 -0.392833700410932 0.0377471321681522 mirMAP -0.164682422606545 3.30852835931196e-06 NA NA NA hsa-miR-92a-3p NFAT5 2.06460102658973 1.44784291084757e-19 -0.392833700410932 0.0377471321681522 miRNATAP -0.170110315406311 8.64402750959781e-06 NA NA NA hsa-miR-92b-3p NFAT5 1.20409245530001 3.41055816361655e-06 -0.392833700410932 0.0377471321681522 miRNATAP -0.217775968771398 2.32261018870722e-10 NA NA NA hsa-miR-125a-5p NFATC1 0.599529391575274 0.0102300147180307 -1.85038550878621 5.2595171540405e-08 miRanda -0.271857756138489 0.000146359188361828 NA NA NA hsa-miR-3127-5p NFATC1 1.51846438737133 3.59571251672767e-07 -1.85038550878621 5.2595171540405e-08 MirTarget -0.249740036022457 5.5008583559068e-06 NA NA NA hsa-miR-421 NFATC1 1.17791565395543 6.78526676976629e-06 -1.85038550878621 5.2595171540405e-08 miRanda -0.285336719024401 6.2013105622129e-06 NA NA NA hsa-miR-940 NFATC1 3.21011374578759 2.7923171128495e-14 -1.85038550878621 5.2595171540405e-08 PITA -0.324901980633973 1.03105739407377e-15 NA NA NA hsa-miR-130b-5p NFATC2 2.9963110846538 1.98883029416455e-18 -2.09940213646525 2.77134949511158e-05 MirTarget -0.272734196833187 9.99532798497572e-05 NA NA NA hsa-miR-16-2-3p NFATC2 2.31623086727196 4.29838149388188e-20 -2.09940213646525 2.77134949511158e-05 mirMAP -0.346662368458709 0.000179256594294205 NA NA NA hsa-miR-182-5p NFATC2 3.53923166221814 5.07781258121574e-21 -2.09940213646525 2.77134949511158e-05 mirMAP -0.274974364845855 7.50815876894642e-06 NA NA NA hsa-miR-185-5p NFATC2 2.34016206907488 1.17481626642022e-26 -2.09940213646525 2.77134949511158e-05 MirTarget -0.377810783509097 0.000327278994012812 NA NA NA hsa-miR-186-5p NFATC2 1.47445398888668 3.0781726595413e-15 -2.09940213646525 2.77134949511158e-05 mirMAP -0.437555927141547 0.000604504699648039 NA NA NA hsa-miR-19a-3p NFATC2 3.42309334186656 3.02671914353412e-28 -2.09940213646525 2.77134949511158e-05 mirMAP -0.373437340706404 2.96351119749213e-07 NA NA NA hsa-miR-19b-3p NFATC2 2.49529833021187 1.57028265846699e-23 -2.09940213646525 2.77134949511158e-05 mirMAP -0.469765074696736 3.34509012953115e-07 NA NA NA hsa-miR-200b-5p NFATC2 2.54484902707822 1.59240467582976e-06 -2.09940213646525 2.77134949511158e-05 mirMAP -0.146133495085517 0.00444174699182292 NA NA NA hsa-miR-26b-3p NFATC2 2.18464160365372 2.11543189388328e-18 -2.09940213646525 2.77134949511158e-05 MirTarget -0.44806551147109 1.62954234122775e-06 NA NA NA hsa-miR-27b-5p NFATC2 0.393316367667332 0.051702301924024 -2.09940213646525 2.77134949511158e-05 mirMAP -0.365339117485442 0.00275776764973734 NA NA NA hsa-miR-29a-5p NFATC2 1.46749674755271 3.34605004270294e-07 -2.09940213646525 2.77134949511158e-05 mirMAP;miRNATAP -0.294077626911206 0.000928666235522722 NA NA NA hsa-miR-30c-5p NFATC2 0.778774633108 0.000285599212429136 -2.09940213646525 2.77134949511158e-05 MirTarget;mirMAP -0.368293366563006 0.00123567961865253 NA NA NA hsa-miR-30e-5p NFATC2 1.23904909539663 1.35561917122157e-09 -2.09940213646525 2.77134949511158e-05 MirTarget -0.336147434109482 0.00451047767094652 NA NA NA hsa-miR-320a NFATC2 0.438165828017084 0.0390159073347133 -2.09940213646525 2.77134949511158e-05 MirTarget -0.350663524320559 0.00250598418881894 NA NA NA hsa-miR-320b NFATC2 1.55692969039548 1.41071034251915e-08 -2.09940213646525 2.77134949511158e-05 MirTarget -0.249445194387165 0.00451696496700399 NA NA NA hsa-miR-34a-3p NFATC2 1.75590866103657 8.02801510630657e-09 -2.09940213646525 2.77134949511158e-05 mirMAP -0.301138281046132 0.000597201447878319 NA NA NA hsa-miR-3607-3p NFATC2 2.68532138541128 5.66716351955047e-14 -2.09940213646525 2.77134949511158e-05 MirTarget;mirMAP -0.321712713536906 1.93008019978856e-06 NA NA NA hsa-miR-3613-5p NFATC2 2.64358387329263 1.0373753017245e-24 -2.09940213646525 2.77134949511158e-05 mirMAP -0.582140424179043 1.2743589534383e-10 NA NA NA hsa-miR-484 NFATC2 1.81844463411787 1.82951571230938e-15 -2.09940213646525 2.77134949511158e-05 MirTarget -0.38479959768158 0.000202349753737943 NA NA NA hsa-miR-590-3p NFATC2 2.59289455139753 1.03200520972022e-21 -2.09940213646525 2.77134949511158e-05 mirMAP -0.321676608175333 0.000262933617887873 NA NA NA hsa-miR-7-1-3p NFATC2 1.84950311431067 1.25300363397654e-13 -2.09940213646525 2.77134949511158e-05 mirMAP -0.263604719151409 0.00578811798609279 NA NA NA hsa-miR-15a-5p NFATC3 2.34669284378787 1.69544424500258e-23 -0.344207804593337 0.00548033920348721 MirTarget;miRNATAP -0.129885441359854 5.57888748013133e-08 NA NA NA hsa-miR-222-3p NFATC3 0.851783756239071 0.00266783568486918 -0.344207804593337 0.00548033920348721 MirTarget;miRNATAP -0.110115490467549 1.25225883533778e-07 NA NA NA hsa-miR-29b-3p NFATC3 1.65828197923813 1.02676780888141e-09 -0.344207804593337 0.00548033920348721 MirTarget;miRNATAP -0.172204559034396 1.82486178909652e-16 NA NA NA hsa-miR-30c-5p NFATC3 0.778774633108 0.000285599212429136 -0.344207804593337 0.00548033920348721 MirTarget;miRNATAP -0.114740157277972 3.63344948530422e-05 NA NA NA hsa-miR-361-3p NFATC3 1.07367425434318 1.73142774168958e-09 -0.344207804593337 0.00548033920348721 miRNAWalker2_validate -0.187220216115042 1.24465306058345e-08 NA NA NA hsa-miR-130b-5p NFATC4 2.9963110846538 1.98883029416455e-18 -1.80092988307702 3.48834735342005e-10 mirMAP -0.137235836741862 0.000756045425262512 NA NA NA hsa-miR-15b-3p NFATC4 2.33847028227712 4.29662877950836e-19 -1.80092988307702 3.48834735342005e-10 mirMAP -0.42678455481147 1.50897022571625e-17 NA NA NA hsa-miR-181a-2-3p NFATC4 2.19062681262366 3.81790102612782e-13 -1.80092988307702 3.48834735342005e-10 mirMAP -0.195817485216201 1.65164425285929e-05 NA NA NA hsa-miR-181a-5p NFATC4 2.29556023480783 1.8138457900616e-21 -1.80092988307702 3.48834735342005e-10 mirMAP -0.232958279655687 3.02940033007413e-05 NA NA NA hsa-miR-181b-5p NFATC4 2.49307679431293 3.92829250217627e-20 -1.80092988307702 3.48834735342005e-10 mirMAP -0.262874063527659 1.04543846165047e-07 NA NA NA hsa-miR-185-3p NFATC4 2.3922478518806 1.3373426768452e-14 -1.80092988307702 3.48834735342005e-10 MirTarget -0.271046230259512 4.4211964130384e-10 NA NA NA hsa-miR-2355-5p NFATC4 1.32510310704724 8.25139516692683e-07 -1.80092988307702 3.48834735342005e-10 MirTarget -0.365394782747818 7.50941976584262e-13 NA NA NA hsa-miR-29b-3p NFATC4 1.65828197923813 1.02676780888141e-09 -1.80092988307702 3.48834735342005e-10 miRNATAP -0.215973494706709 2.3206094912252e-05 NA NA NA hsa-miR-320b NFATC4 1.55692969039548 1.41071034251915e-08 -1.80092988307702 3.48834735342005e-10 miRanda;mirMAP -0.260870260943582 2.24547536842287e-07 NA NA NA hsa-miR-34c-5p NFATC4 2.07190852984647 7.35776320806257e-08 -1.80092988307702 3.48834735342005e-10 miRanda -0.136831648591325 0.000394221428295672 NA NA NA hsa-miR-3607-3p NFATC4 2.68532138541128 5.66716351955047e-14 -1.80092988307702 3.48834735342005e-10 miRNATAP -0.251671136039063 8.25714813158393e-11 NA NA NA hsa-miR-361-3p NFATC4 1.07367425434318 1.73142774168958e-09 -1.80092988307702 3.48834735342005e-10 mirMAP -0.397492986056446 3.76815247508252e-07 NA NA NA hsa-miR-423-5p NFATC4 0.963563145758616 9.86109015204915e-07 -1.80092988307702 3.48834735342005e-10 miRNATAP -0.289483218215484 5.20887036793855e-05 NA NA NA hsa-miR-484 NFATC4 1.81844463411787 1.82951571230938e-15 -1.80092988307702 3.48834735342005e-10 MirTarget;miRNATAP -0.319008427014768 8.35906924043843e-08 NA NA NA hsa-miR-625-5p NFATC4 1.42540152147292 1.95797147911206e-06 -1.80092988307702 3.48834735342005e-10 mirMAP -0.255935845388402 5.19970914763295e-07 NA NA NA hsa-miR-629-3p NFATC4 2.36570947321815 1.33458201201618e-11 -1.80092988307702 3.48834735342005e-10 mirMAP -0.317779815801302 3.14548353729131e-13 NA NA NA hsa-miR-940 NFATC4 3.21011374578759 2.7923171128495e-14 -1.80092988307702 3.48834735342005e-10 miRNATAP -0.168817588938824 1.62478907216658e-06 NA NA NA hsa-miR-429 NOS3 4.48815175680773 2.44117492218206e-17 -0.878800989819862 0.000752437995889313 miRanda -0.132117856078783 4.86582987596031e-09 NA NA NA hsa-miR-29c-3p NRAS -0.00968972577705429 0.97099586346872 0.638705716882092 3.80929355945655e-05 miRNATAP -0.151007715222895 7.79757166468808e-08 NA NA NA hsa-miR-664a-3p NRAS 0.634721925861133 0.00520070178640421 0.638705716882092 3.80929355945655e-05 MirTarget -0.156789929856636 2.10592676639858e-06 NA NA NA hsa-miR-126-5p PIK3CA 0.895338176458417 2.33372756450713e-05 -0.151828236462886 0.321284398928338 mirMAP -0.103377544898631 0.00298975306098663 NA NA NA hsa-miR-186-5p PIK3CA 1.47445398888668 3.0781726595413e-15 -0.151828236462886 0.321284398928338 mirMAP -0.101671973753504 0.00842161241015832 NA NA NA hsa-miR-320a PIK3CA 0.438165828017084 0.0390159073347133 -0.151828236462886 0.321284398928338 miRanda -0.153857910084833 9.6763748473785e-06 NA NA NA hsa-miR-10b-5p PIK3CD -0.155951595811628 0.555006386998027 -0.775351667927902 0.021645534884375 miRNAWalker2_validate -0.175760207889201 0.004748835358114 NA NA NA hsa-miR-1468-5p PIK3CD 0.0469536064343461 0.881810795145912 -0.775351667927902 0.021645534884375 MirTarget -0.223784917601258 1.49208556354691e-05 NA NA NA hsa-miR-29c-3p PIK3CD -0.00968972577705429 0.97099586346872 -0.775351667927902 0.021645534884375 mirMAP -0.250794863940076 4.41169066967662e-05 NA NA NA hsa-miR-30b-3p PIK3CD 0.834142820354026 0.000972582820878813 -0.775351667927902 0.021645534884375 MirTarget -0.531045557079738 2.22640594160628e-17 NA NA NA hsa-miR-30b-5p PIK3CD 0.800822374912712 0.000133601914525413 -0.775351667927902 0.021645534884375 MirTarget -0.411457344396036 9.99002635635066e-08 NA NA NA hsa-miR-30c-5p PIK3CD 0.778774633108 0.000285599212429136 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.461850084291099 7.5210996634642e-10 NA NA NA hsa-miR-30d-5p PIK3CD 0.675423997639582 0.00270618816039773 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.733785480070449 9.30689014359708e-27 NA NA NA hsa-miR-30e-5p PIK3CD 1.23904909539663 1.35561917122157e-09 -0.775351667927902 0.021645534884375 MirTarget -0.597650735147178 7.00788139486401e-15 NA NA NA hsa-miR-320a PIK3CD 0.438165828017084 0.0390159073347133 -0.775351667927902 0.021645534884375 miRanda -0.437629854617933 1.07773535518864e-08 NA NA NA hsa-miR-320b PIK3CD 1.55692969039548 1.41071034251915e-08 -0.775351667927902 0.021645534884375 miRanda -0.282783919094812 1.19379715607107e-06 NA NA NA hsa-miR-324-5p PIK3CD 2.95683728155095 1.32960514360912e-20 -0.775351667927902 0.021645534884375 miRanda -0.265511883710764 4.30342749668002e-08 NA NA NA hsa-miR-3913-5p PIK3CD 2.44353493655328 8.95279496632448e-15 -0.775351667927902 0.021645534884375 mirMAP -0.395313104822511 3.24743386923115e-15 NA NA NA hsa-miR-421 PIK3CD 1.17791565395543 6.78526676976629e-06 -0.775351667927902 0.021645534884375 miRanda -0.235490163150307 0.000146542275873157 NA NA NA hsa-miR-484 PIK3CD 1.81844463411787 1.82951571230938e-15 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.387158078139352 1.61214627982237e-08 NA NA NA hsa-miR-148b-3p PIK3CG 1.97815018171325 6.07715327281595e-26 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.598035215538084 7.05982657783629e-10 NA NA NA hsa-miR-335-3p PIK3CG 3.08791651139852 5.31309869723517e-12 -1.04493260087656 0.00941484120426313 mirMAP -0.182751911295676 1.44284270796844e-05 NA NA NA hsa-miR-3607-3p PIK3CG 2.68532138541128 5.66716351955047e-14 -1.04493260087656 0.00941484120426313 mirMAP -0.166734433414221 0.00216182223501734 NA NA NA hsa-miR-421 PIK3CG 1.17791565395543 6.78526676976629e-06 -1.04493260087656 0.00941484120426313 miRanda -0.208294811185602 0.00505346682917229 NA NA NA hsa-miR-101-5p PIK3R1 0.782067874775122 0.00443725251526842 -1.16357283690918 1.63774086027679e-06 MirTarget -0.115568250605295 0.00948870207662742 NA NA NA hsa-miR-103a-3p PIK3R1 1.44083190496858 1.53799939616416e-13 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.175702483843164 0.00322284399016944 NA NA NA hsa-miR-106b-5p PIK3R1 2.46782146831112 1.36171495805632e-23 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.24930934707311 3.35624085651532e-08 NA NA NA hsa-miR-107 PIK3R1 1.30977326593435 1.30372468603965e-11 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.201353514049413 0.000854368494298006 NA NA NA hsa-miR-127-5p PIK3R1 1.19850695520181 4.10976607177645e-05 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.164276045731973 4.35688271416755e-05 24004856 Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR 127 in human bladder cancer; These findings provide new insights into the role of miRNAs in the pathway of cancer and give us a hypothesis that miR-127 might play a similar role in regulation and control of PIK3R1 bladder cancer hsa-miR-1301-3p PIK3R1 2.54959518791507 5.26618591274892e-18 -1.16357283690918 1.63774086027679e-06 MirTarget -0.146009716288673 0.000153002833756534 NA NA NA hsa-miR-132-3p PIK3R1 0.156276992635384 0.408190812100704 -1.16357283690918 1.63774086027679e-06 MirTarget -0.197496588157407 0.00191277589406782 NA NA NA hsa-miR-15a-5p PIK3R1 2.34669284378787 1.69544424500258e-23 -1.16357283690918 1.63774086027679e-06 MirTarget -0.142181030175195 0.00308171212654804 NA NA NA hsa-miR-15b-5p PIK3R1 1.57112623124278 9.14247846750597e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203388250610072 0.000112366544945594 NA NA NA hsa-miR-16-2-3p PIK3R1 2.31623086727196 4.29838149388188e-20 -1.16357283690918 1.63774086027679e-06 MirTarget -0.207543782293348 3.49270114018875e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.75824877145857 1.68592440033108e-16 -1.16357283690918 1.63774086027679e-06 MirTarget -0.20266090985161 0.000166722510489398 NA NA NA hsa-miR-17-5p PIK3R1 3.2710598467455 9.93128340539455e-27 -1.16357283690918 1.63774086027679e-06 MirTarget;TargetScan;miRNATAP -0.194269031204595 7.03363082546611e-08 NA NA NA hsa-miR-185-5p PIK3R1 2.34016206907488 1.17481626642022e-26 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.305558512858305 1.29388513669652e-09 NA NA NA hsa-miR-186-5p PIK3R1 1.47445398888668 3.0781726595413e-15 -1.16357283690918 1.63774086027679e-06 mirMAP -0.274872917366815 8.27585129634137e-06 NA NA NA hsa-miR-188-5p PIK3R1 2.52825126596644 6.78099435999778e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.185661747772095 2.50402606338374e-07 NA NA NA hsa-miR-199a-3p PIK3R1 0.640600337515787 0.0380326905134914 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.156998919927599 4.11373421997523e-05 NA NA NA hsa-miR-199b-3p PIK3R1 0.643923492750702 0.0371742251925406 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.157124307871095 4.00275047495595e-05 NA NA NA hsa-miR-20a-5p PIK3R1 3.15577933619191 4.19753346442454e-25 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.184775072209508 3.70396511881761e-07 NA NA NA hsa-miR-21-5p PIK3R1 2.73773305747971 1.38864982139576e-43 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.344443286817705 1.08270725892964e-10 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.357878936470387 0.232446214501331 -1.16357283690918 1.63774086027679e-06 MirTarget -0.126995222417611 0.00147059810557586 NA NA NA hsa-miR-22-5p PIK3R1 1.88011544159252 1.63978222572222e-16 -1.16357283690918 1.63774086027679e-06 mirMAP -0.292552038138818 3.89552165607854e-09 NA NA NA hsa-miR-222-3p PIK3R1 0.851783756239071 0.00266783568486918 -1.16357283690918 1.63774086027679e-06 MirTarget -0.122260306324505 0.00346350093932025 NA NA NA hsa-miR-29a-3p PIK3R1 -0.35074463683376 0.161238718982428 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.197768036084372 3.04095884680599e-05 NA NA NA hsa-miR-29b-3p PIK3R1 1.65828197923813 1.02676780888141e-09 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.226570180742736 9.59427672061032e-08 NA NA NA hsa-miR-3065-5p PIK3R1 2.74629919868982 1.86846589298284e-08 -1.16357283690918 1.63774086027679e-06 MirTarget;mirMAP;miRNATAP -0.121456370441073 3.04699134862982e-05 NA NA NA hsa-miR-369-3p PIK3R1 0.946781510019564 0.00134850306966842 -1.16357283690918 1.63774086027679e-06 PITA -0.165045838001649 3.68847028364345e-05 NA NA NA hsa-miR-424-5p PIK3R1 1.61930224569578 1.89642549274994e-10 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203727044936863 7.79524954848401e-06 NA NA NA hsa-miR-450b-5p PIK3R1 1.69244418548325 1.68064054148881e-10 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.119371689321084 0.0066882062526509 NA NA NA hsa-miR-455-3p PIK3R1 3.06093594997644 3.54590649799868e-16 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.151223028806072 5.34851043578223e-07 NA NA NA hsa-miR-485-3p PIK3R1 0.442820096243914 0.166634696770945 -1.16357283690918 1.63774086027679e-06 mirMAP -0.104228852223792 0.00542492277409986 NA NA NA hsa-miR-493-5p PIK3R1 0.847772103665986 0.00528678068747754 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.141629319654 0.000286613564823519 NA NA NA hsa-miR-532-3p PIK3R1 1.96631878320218 4.53421954361695e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.183574493282594 1.45132602336302e-05 NA NA NA hsa-miR-584-5p PIK3R1 2.7326672683732 9.92677936962233e-12 -1.16357283690918 1.63774086027679e-06 mirMAP -0.136506526285572 1.76178566940588e-06 NA NA NA hsa-miR-589-3p PIK3R1 2.51971841868825 2.39125940264107e-11 -1.16357283690918 1.63774086027679e-06 mirMAP -0.146863008859422 2.43953052082368e-05 NA NA NA hsa-miR-590-3p PIK3R1 2.59289455139753 1.03200520972022e-21 -1.16357283690918 1.63774086027679e-06 miRanda;mirMAP -0.251414695908109 2.6774008322444e-09 NA NA NA hsa-miR-590-5p PIK3R1 3.18300989862077 2.06813568597893e-26 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.233958943001206 5.13569363038349e-10 NA NA NA hsa-miR-629-3p PIK3R1 2.36570947321815 1.33458201201618e-11 -1.16357283690918 1.63774086027679e-06 MirTarget -0.157530213698435 2.37486100403133e-05 NA NA NA hsa-miR-93-5p PIK3R1 3.03961860136032 1.11672209617395e-24 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.155676924698248 3.5347453293642e-05 NA NA NA hsa-miR-96-5p PIK3R1 4.89433085814374 1.92000659886961e-31 -1.16357283690918 1.63774086027679e-06 TargetScan;miRNATAP -0.102966561567807 0.000122371084822612 NA NA NA hsa-miR-1271-5p PIK3R3 0.970418832993172 0.000609742584380688 -0.627704444396048 0.00578594022892978 mirMAP -0.151257171385516 9.56593049733625e-05 NA NA NA hsa-miR-18a-3p PIK3R3 2.14813400940323 2.23460809936028e-06 -0.627704444396048 0.00578594022892978 miRNAWalker2_validate -0.10342220794232 0.000634896497880219 NA NA NA hsa-miR-19a-3p PIK3R3 3.42309334186656 3.02671914353412e-28 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.120784849374387 0.0002630092907536 NA NA NA hsa-miR-19b-3p PIK3R3 2.49529833021187 1.57028265846699e-23 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.146052627292238 0.000482454548266062 NA NA NA hsa-miR-222-5p PIK3R3 1.25632771414778 0.000138653440511922 -0.627704444396048 0.00578594022892978 mirMAP -0.146201383530692 9.47483044017924e-06 NA NA NA hsa-miR-26b-5p PIK3R3 0.885393662798425 3.2116297961629e-06 -0.627704444396048 0.00578594022892978 miRNATAP -0.184498425433638 0.00145436639404193 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.55384379072167 4.76870585070176e-05 -0.627704444396048 0.00578594022892978 mirMAP -0.182944374912975 8.7655907053222e-10 NA NA NA hsa-miR-365a-3p PIK3R3 -0.0388985816963467 0.859114494267351 -0.627704444396048 0.00578594022892978 MirTarget -0.222976439335601 9.85809729911043e-06 NA NA NA hsa-miR-511-5p PIK3R3 1.04499312543772 0.00234126154508174 -0.627704444396048 0.00578594022892978 MirTarget -0.132527709680848 3.18921565069019e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-92a-3p PIK3R3 2.06460102658973 1.44784291084757e-19 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.185970971603602 5.73870254874264e-05 NA NA NA hsa-miR-107 PIK3R5 1.30977326593435 1.30372468603965e-11 -0.990769658200862 0.00792713202187119 miRanda -0.533513362792699 4.18278914923372e-09 NA NA NA hsa-miR-125a-5p PIK3R5 0.599529391575274 0.0102300147180307 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.398754902125041 2.22481895610409e-07 NA NA NA hsa-miR-182-5p PIK3R5 3.53923166221814 5.07781258121574e-21 -0.990769658200862 0.00792713202187119 MirTarget -0.391730270801049 4.50362857100536e-19 NA NA NA hsa-miR-185-5p PIK3R5 2.34016206907488 1.17481626642022e-26 -0.990769658200862 0.00792713202187119 MirTarget -0.277336834855249 0.000367374066791577 NA NA NA hsa-miR-18a-3p PIK3R5 2.14813400940323 2.23460809936028e-06 -0.990769658200862 0.00792713202187119 MirTarget -0.132688083528877 0.0077571943603639 NA NA NA hsa-miR-330-5p PIK3R5 1.15100069700871 4.85551805046014e-07 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.220865262481851 0.00496435762424894 NA NA NA hsa-miR-944 PIK3R5 2.91186649218281 1.31574753528144e-06 -0.990769658200862 0.00792713202187119 mirMAP -0.201291119960673 1.82909637448261e-11 NA NA NA hsa-miR-140-5p PLA2G12A 0.844753502512594 3.73722278438606e-05 -0.226923565397224 0.110320132886187 miRanda -0.14801862288608 8.44927388616416e-06 NA NA NA hsa-miR-142-3p PLA2G12A 2.75247908790621 1.45636065474764e-12 -0.226923565397224 0.110320132886187 miRanda -0.132479438643194 1.31230119499281e-15 NA NA NA hsa-miR-142-5p PLA2G12A 1.17581605694506 0.0018174701991234 -0.226923565397224 0.110320132886187 mirMAP -0.152006113752674 2.16543248749224e-18 NA NA NA hsa-miR-29a-5p PLA2G12A 1.46749674755271 3.34605004270294e-07 -0.226923565397224 0.110320132886187 mirMAP -0.162300143536253 2.86585419004462e-11 NA NA NA hsa-miR-361-5p PLA2G2A 0.971859117235239 5.30236555707088e-09 -3.40473736904758 6.12351716198306e-05 miRanda -1.54030311209047 2.69460491948461e-10 NA NA NA hsa-miR-491-5p PLA2G2A 0.615770352820862 0.0418295628761654 -3.40473736904758 6.12351716198306e-05 miRanda -0.808306666640749 2.54440652464924e-08 NA NA NA hsa-miR-15a-5p PLA2G2D 2.34669284378787 1.69544424500258e-23 -1.02276507955976 0.189798951526849 miRNAWalker2_validate -0.404850472000017 0.00807397819916615 NA NA NA hsa-miR-16-1-3p PLA2G2D 2.56983217111073 3.02262181237943e-20 -1.02276507955976 0.189798951526849 mirMAP -0.48415802760318 0.000261010539116146 NA NA NA hsa-miR-125b-5p PLA2G2F -1.16462950151259 0.000288900271798384 3.13177891691247 0.00146365751535567 mirMAP -0.775103233945353 1.21552641246288e-07 NA NA NA hsa-miR-18a-3p PLA2G2F 2.14813400940323 2.23460809936028e-06 3.13177891691247 0.00146365751535567 mirMAP -0.485063580878413 0.000219436625550264 NA NA NA hsa-miR-2355-5p PLA2G2F 1.32510310704724 8.25139516692683e-07 3.13177891691247 0.00146365751535567 MirTarget -0.725846284205262 3.52692947225181e-05 NA NA NA hsa-miR-1301-3p PLA2G4A 2.54959518791507 5.26618591274892e-18 -1.76911972497501 1.36780052043494e-06 MirTarget -0.271432528908166 2.86828986780574e-06 NA NA NA hsa-miR-142-3p PLA2G4A 2.75247908790621 1.45636065474764e-12 -1.76911972497501 1.36780052043494e-06 miRanda -0.13710181671413 0.00221782421174375 NA NA NA hsa-miR-146b-5p PLA2G4A 1.75587235896724 1.15724631266659e-07 -1.76911972497501 1.36780052043494e-06 miRNAWalker2_validate -0.138508703164524 0.00953802605681816 NA NA NA hsa-miR-181a-5p PLA2G4A 2.29556023480783 1.8138457900616e-21 -1.76911972497501 1.36780052043494e-06 MirTarget -0.210530558529152 0.00302794528753118 NA NA NA hsa-miR-181c-5p PLA2G4A 1.58587920618301 1.57506918816933e-10 -1.76911972497501 1.36780052043494e-06 MirTarget -0.263675364814697 0.000199093485008343 NA NA NA hsa-miR-181d-5p PLA2G4A 1.52204912185579 9.2693319057748e-08 -1.76911972497501 1.36780052043494e-06 MirTarget -0.190977664531932 0.00213336065376659 NA NA NA hsa-miR-33a-3p PLA2G4A 1.72765312072219 1.51784443453521e-07 -1.76911972497501 1.36780052043494e-06 MirTarget -0.156816958703784 0.00805830236676267 NA NA NA hsa-miR-361-5p PLA2G4A 0.971859117235239 5.30236555707088e-09 -1.76911972497501 1.36780052043494e-06 miRanda -0.44352221685407 3.38401198401618e-05 NA NA NA hsa-miR-362-3p PLA2G4A 2.0756816987665 3.89026064579331e-12 -1.76911972497501 1.36780052043494e-06 miRanda -0.344359237218545 7.62718654263185e-09 NA NA NA hsa-miR-590-3p PLA2G4A 2.59289455139753 1.03200520972022e-21 -1.76911972497501 1.36780052043494e-06 miRanda -0.330281844381331 2.6395869433225e-07 NA NA NA hsa-miR-664a-3p PLA2G4E 0.634721925861133 0.00520070178640421 -0.457051657544898 0.526340607142826 mirMAP -0.528605473505062 0.000587247707984126 NA NA NA hsa-miR-125a-5p PLA2G5 0.599529391575274 0.0102300147180307 -2.98039017984699 5.45430675918713e-08 miRanda -0.43402319502752 0.000171953535886849 NA NA NA hsa-miR-128-3p PLA2G5 1.63756041666078 6.79626586407187e-14 -2.98039017984699 5.45430675918713e-08 miRNAWalker2_validate -1.13154129122494 4.25362784424371e-23 NA NA NA hsa-miR-330-5p PLA2G5 1.15100069700871 4.85551805046014e-07 -2.98039017984699 5.45430675918713e-08 miRanda -0.87956954375258 9.6120825351781e-15 NA NA NA hsa-miR-339-5p PLA2G5 2.68710938429893 3.03134080808154e-16 -2.98039017984699 5.45430675918713e-08 miRanda -0.538476541600716 3.05043859695343e-12 NA NA NA hsa-miR-361-5p PLA2G5 0.971859117235239 5.30236555707088e-09 -2.98039017984699 5.45430675918713e-08 miRanda -1.68294189322315 8.66159008701736e-29 NA NA NA hsa-miR-429 PLA2G5 4.48815175680773 2.44117492218206e-17 -2.98039017984699 5.45430675918713e-08 miRanda -0.491944311759968 7.17164621174772e-27 NA NA NA hsa-miR-589-3p PLA2G5 2.51971841868825 2.39125940264107e-11 -2.98039017984699 5.45430675918713e-08 MirTarget -0.606412431420136 3.35739867930122e-15 NA NA NA hsa-miR-590-3p PLA2G5 2.59289455139753 1.03200520972022e-21 -2.98039017984699 5.45430675918713e-08 miRanda;miRNATAP -0.839581331965807 2.56966308437666e-19 NA NA NA hsa-miR-590-5p PLA2G5 3.18300989862077 2.06813568597893e-26 -2.98039017984699 5.45430675918713e-08 miRanda -0.832629471378237 5.18479097856289e-24 NA NA NA hsa-miR-2355-3p PLA2G6 1.2671753520641 5.70559238344897e-05 0.223163826700851 0.393344374716363 MirTarget -0.267411816628485 2.66963375924508e-11 NA NA NA hsa-miR-30a-5p PLCG1 -0.878357906436456 0.000509952992366057 0.210047767003971 0.127182592483321 miRNATAP -0.112898333505152 1.47927804909672e-05 NA NA NA hsa-miR-590-3p PLCG2 2.59289455139753 1.03200520972022e-21 -0.735903252798082 0.00875075341761775 miRanda -0.130533105835182 0.00802002106519342 NA NA NA hsa-let-7f-5p PPP3CA 0.495648727272215 0.00355972741198794 -0.281979431665802 0.0843014975757299 miRNATAP -0.145174821876866 0.00196996187493329 NA NA NA hsa-let-7g-5p PPP3CA 1.20061455355116 1.50237505511483e-12 -0.281979431665802 0.0843014975757299 miRNATAP -0.256650979931267 1.4045207283454e-08 NA NA NA hsa-miR-106a-5p PPP3CA 2.48882002962836 1.99757727374521e-12 -0.281979431665802 0.0843014975757299 miRNATAP -0.11191172835948 1.79556273427309e-07 NA NA NA hsa-miR-106b-5p PPP3CA 2.46782146831112 1.36171495805632e-23 -0.281979431665802 0.0843014975757299 miRNATAP -0.184105953911301 6.84398280050895e-10 NA NA NA hsa-miR-17-3p PPP3CA 2.2704817679209 1.1667437320211e-22 -0.281979431665802 0.0843014975757299 MirTarget -0.131133816129638 4.79999765543855e-05 NA NA NA hsa-miR-186-5p PPP3CA 1.47445398888668 3.0781726595413e-15 -0.281979431665802 0.0843014975757299 mirMAP -0.185694598107894 5.66511837519636e-06 NA NA NA hsa-miR-194-5p PPP3CA 1.8992998339217 3.76507853301977e-10 -0.281979431665802 0.0843014975757299 MirTarget -0.17070662815415 7.35898582017249e-12 NA NA NA hsa-miR-20a-5p PPP3CA 3.15577933619191 4.19753346442454e-25 -0.281979431665802 0.0843014975757299 miRNATAP -0.109419648077418 6.17460161232474e-06 NA NA NA hsa-miR-20b-5p PPP3CA 2.07706563022469 1.10107236083433e-05 -0.281979431665802 0.0843014975757299 miRNATAP -0.113387749946454 1.85473104688059e-12 NA NA NA hsa-miR-30c-5p PPP3CA 0.778774633108 0.000285599212429136 -0.281979431665802 0.0843014975757299 miRNATAP -0.212081199369466 4.85681407465908e-09 NA NA NA hsa-miR-30d-5p PPP3CA 0.675423997639582 0.00270618816039773 -0.281979431665802 0.0843014975757299 miRNATAP -0.142883121139453 4.34068465949306e-05 NA NA NA hsa-miR-501-3p PPP3CA 1.83132758513743 1.10971547702065e-10 -0.281979431665802 0.0843014975757299 MirTarget;PITA;miRNATAP -0.114452652427796 2.34298968304304e-05 NA NA NA hsa-miR-502-3p PPP3CA 1.50560877085049 1.2647489756373e-11 -0.281979431665802 0.0843014975757299 MirTarget;PITA;miRNATAP -0.15529134445823 7.08901270771209e-06 NA NA NA hsa-miR-664a-3p PPP3CA 0.634721925861133 0.00520070178640421 -0.281979431665802 0.0843014975757299 mirMAP -0.150747155909677 1.3336356409105e-05 NA NA NA hsa-miR-7-1-3p PPP3CA 1.84950311431067 1.25300363397654e-13 -0.281979431665802 0.0843014975757299 MirTarget;mirMAP -0.119727173710851 9.40140707131449e-05 NA NA NA hsa-miR-93-3p PPP3CA 2.85383869771942 5.64481766902125e-23 -0.281979431665802 0.0843014975757299 miRNATAP -0.152353546507485 2.15079066361371e-09 NA NA NA hsa-miR-93-5p PPP3CA 3.03961860136032 1.11672209617395e-24 -0.281979431665802 0.0843014975757299 miRNATAP -0.156066415468858 2.44288871078656e-10 NA NA NA hsa-miR-107 PPP3CB 1.30977326593435 1.30372468603965e-11 -1.03671584843429 6.12489584217064e-15 miRanda -0.224024061633064 1.13198598297881e-11 NA NA NA hsa-miR-15a-5p PPP3CB 2.34669284378787 1.69544424500258e-23 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.188034579267018 6.2219880807044e-13 NA NA NA hsa-miR-15b-5p PPP3CB 1.57112623124278 9.14247846750597e-13 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.245380830384666 5.15260568991425e-18 NA NA NA hsa-miR-16-5p PPP3CB 1.75824877145857 1.68592440033108e-16 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.219222038672189 7.36535140884335e-14 NA NA NA hsa-miR-20a-3p PPP3CB 2.92621109947706 2.49504904635375e-17 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.113868623377048 9.37084199962394e-10 NA NA NA hsa-miR-26b-5p PPP3CB 0.885393662798425 3.2116297961629e-06 -1.03671584843429 6.12489584217064e-15 MirTarget;miRNATAP -0.129362759155204 0.000196474595826764 NA NA NA hsa-miR-30c-5p PPP3CB 0.778774633108 0.000285599212429136 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.165551300673001 5.92944884537219e-08 NA NA NA hsa-miR-30d-5p PPP3CB 0.675423997639582 0.00270618816039773 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.128345099197797 1.20380214861929e-05 NA NA NA hsa-miR-320a PPP3CB 0.438165828017084 0.0390159073347133 -1.03671584843429 6.12489584217064e-15 miRanda -0.133683103961461 1.89473747516991e-05 NA NA NA hsa-miR-320b PPP3CB 1.55692969039548 1.41071034251915e-08 -1.03671584843429 6.12489584217064e-15 miRanda -0.157984627594008 1.12882018634839e-11 NA NA NA hsa-miR-330-5p PPP3CB 1.15100069700871 4.85551805046014e-07 -1.03671584843429 6.12489584217064e-15 MirTarget;PITA;miRanda -0.122279132326624 1.90117350044819e-05 NA NA NA hsa-miR-339-5p PPP3CB 2.68710938429893 3.03134080808154e-16 -1.03671584843429 6.12489584217064e-15 miRanda -0.129274316344838 1.00359131009696e-11 NA NA NA hsa-miR-361-5p PPP3CB 0.971859117235239 5.30236555707088e-09 -1.03671584843429 6.12489584217064e-15 miRanda -0.319599472524393 7.32960352437588e-17 NA NA NA hsa-miR-421 PPP3CB 1.17791565395543 6.78526676976629e-06 -1.03671584843429 6.12489584217064e-15 miRanda -0.107753543524587 1.70411972807069e-05 NA NA NA hsa-miR-429 PPP3CB 4.48815175680773 2.44117492218206e-17 -1.03671584843429 6.12489584217064e-15 miRanda -0.104170748345545 1.10824048087982e-19 NA NA NA hsa-miR-501-5p PPP3CB 1.93654809410041 1.3779381780759e-10 -1.03671584843429 6.12489584217064e-15 PITA;miRNATAP -0.110941325807012 4.19796167603695e-07 NA NA NA hsa-miR-590-3p PPP3CB 2.59289455139753 1.03200520972022e-21 -1.03671584843429 6.12489584217064e-15 miRanda -0.160737546369274 6.57567642585996e-12 NA NA NA hsa-miR-7-1-3p PPP3CB 1.84950311431067 1.25300363397654e-13 -1.03671584843429 6.12489584217064e-15 mirMAP -0.170702158890249 1.5272735318301e-11 NA NA NA hsa-miR-361-5p PPP3CC 0.971859117235239 5.30236555707088e-09 -0.895441456978914 1.07671854464434e-07 miRanda -0.275565592476708 1.65394541713718e-08 NA NA NA hsa-miR-500a-3p PPP3CC 1.47161373123699 5.30571342631915e-09 -0.895441456978914 1.07671854464434e-07 MirTarget;miRNATAP -0.11299814981742 0.000453955248711429 NA NA NA hsa-miR-502-3p PPP3CC 1.50560877085049 1.2647489756373e-11 -0.895441456978914 1.07671854464434e-07 MirTarget;PITA;miRNATAP -0.137316418088144 0.000157963764790067 NA NA NA hsa-miR-101-3p PPP3R1 0.522819989585461 0.00375627731618038 -0.0284423401171923 0.760566460331176 miRNATAP -0.130896280595902 1.18496266678438e-07 NA NA NA hsa-miR-142-5p PRKCA 1.17581605694506 0.0018174701991234 -1.04253532292201 0.000330447904822586 mirMAP -0.155281859758494 2.83714874751982e-05 NA NA NA hsa-miR-146a-5p PRKCA 1.19829319599115 0.00157081974524452 -1.04253532292201 0.000330447904822586 mirMAP -0.131710886401928 0.000370553312736514 NA NA NA hsa-miR-146b-5p PRKCA 1.75587235896724 1.15724631266659e-07 -1.04253532292201 0.000330447904822586 mirMAP -0.178218054737334 2.01234944480139e-05 NA NA NA hsa-miR-150-5p PRKCA -0.105827294491332 0.799351458244375 -1.04253532292201 0.000330447904822586 mirMAP -0.124697814540873 0.00022848052592286 NA NA NA hsa-miR-17-3p PRKCA 2.2704817679209 1.1667437320211e-22 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.163389027302081 0.00492702694664717 NA NA NA hsa-miR-181a-5p PRKCA 2.29556023480783 1.8138457900616e-21 -1.04253532292201 0.000330447904822586 mirMAP -0.332076264197257 1.58885695452918e-09 NA NA NA hsa-miR-181b-5p PRKCA 2.49307679431293 3.92829250217627e-20 -1.04253532292201 0.000330447904822586 mirMAP -0.255352495229191 2.20407502467148e-07 NA NA NA hsa-miR-181c-5p PRKCA 1.58587920618301 1.57506918816933e-10 -1.04253532292201 0.000330447904822586 mirMAP -0.187181736198993 0.000814130560426752 NA NA NA hsa-miR-183-5p PRKCA 4.19757025992371 4.79612296318304e-26 -1.04253532292201 0.000330447904822586 miRNATAP -0.167765439348368 3.7027196892035e-07 NA NA NA hsa-miR-186-5p PRKCA 1.47445398888668 3.0781726595413e-15 -1.04253532292201 0.000330447904822586 miRNATAP -0.372737117584225 3.41129073481267e-07 NA NA NA hsa-miR-193b-3p PRKCA 2.25711804611899 4.1940744806631e-14 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.184015097403191 5.6276271806172e-05 NA NA NA hsa-miR-193b-5p PRKCA 1.59567208918739 4.89398272459427e-08 -1.04253532292201 0.000330447904822586 mirMAP -0.144499830970602 0.00240910945358069 NA NA NA hsa-miR-1976 PRKCA 2.06550563678192 7.81396978619772e-18 -1.04253532292201 0.000330447904822586 miRNATAP -0.17995688234711 0.00150164194068263 NA NA NA hsa-miR-19b-1-5p PRKCA 2.57951428759379 4.31576118703427e-20 -1.04253532292201 0.000330447904822586 mirMAP -0.172921934994649 0.000451924002079924 NA NA NA hsa-miR-200b-3p PRKCA 3.78235093249346 3.18343003239465e-14 -1.04253532292201 0.000330447904822586 TargetScan -0.114961109829389 2.45352651543255e-05 NA NA NA hsa-miR-200c-3p PRKCA 3.50132673580082 2.42716349086937e-15 -1.04253532292201 0.000330447904822586 miRNATAP -0.158977004957444 1.80034178057763e-07 NA NA NA hsa-miR-214-3p PRKCA -0.176344800034733 0.642485503428886 -1.04253532292201 0.000330447904822586 mirMAP -0.126245731078837 0.000711043186976772 NA NA NA hsa-miR-22-5p PRKCA 1.88011544159252 1.63978222572222e-16 -1.04253532292201 0.000330447904822586 mirMAP -0.258621101167742 1.45994385651039e-05 NA NA NA hsa-miR-24-2-5p PRKCA 2.07171035460647 3.15853539996136e-16 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.190869345201713 0.000384051796932142 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-339-5p PRKCA 2.68710938429893 3.03134080808154e-16 -1.04253532292201 0.000330447904822586 mirMAP -0.146901538113986 0.000377758588526939 NA NA NA hsa-miR-3607-3p PRKCA 2.68532138541128 5.66716351955047e-14 -1.04253532292201 0.000330447904822586 mirMAP -0.141547181715678 0.000312501141538225 NA NA NA hsa-miR-362-5p PRKCA 1.59303749908759 9.582675908797e-08 -1.04253532292201 0.000330447904822586 TargetScan;miRNATAP -0.155938176693359 0.000821123203239911 NA NA NA hsa-miR-369-3p PRKCA 0.946781510019564 0.00134850306966842 -1.04253532292201 0.000330447904822586 PITA;miRNATAP -0.153415665611504 0.0013232753592926 NA NA NA hsa-miR-381-3p PRKCA -0.0821432056113931 0.752465205603634 -1.04253532292201 0.000330447904822586 mirMAP -0.182718955463403 0.000792478176257635 NA NA NA hsa-miR-429 PRKCA 4.48815175680773 2.44117492218206e-17 -1.04253532292201 0.000330447904822586 miRanda;miRNATAP -0.108496235247986 1.950717922572e-05 NA NA NA hsa-miR-450b-5p PRKCA 1.69244418548325 1.68064054148881e-10 -1.04253532292201 0.000330447904822586 PITA;mirMAP;miRNATAP -0.164559118659435 0.00164963824183995 NA NA NA hsa-miR-500a-5p PRKCA 1.72110365584658 3.0807246212659e-10 -1.04253532292201 0.000330447904822586 miRNATAP -0.224298470556856 8.73025451195054e-06 NA NA NA hsa-miR-501-5p PRKCA 1.93654809410041 1.3779381780759e-10 -1.04253532292201 0.000330447904822586 miRNATAP -0.160491119587112 0.000665161220237392 NA NA NA hsa-miR-505-3p PRKCA 1.45322244209148 8.86597629645867e-10 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.17319300539973 0.00317185860747904 NA NA NA hsa-miR-505-5p PRKCA 1.89243395287645 9.82003586561819e-12 -1.04253532292201 0.000330447904822586 mirMAP -0.170760296141889 0.000583545058780229 NA NA NA hsa-miR-532-3p PRKCA 1.96631878320218 4.53421954361695e-13 -1.04253532292201 0.000330447904822586 mirMAP;miRNATAP -0.153994961004655 0.00236643084778704 NA NA NA hsa-miR-590-3p PRKCA 2.59289455139753 1.03200520972022e-21 -1.04253532292201 0.000330447904822586 PITA;miRanda;mirMAP;miRNATAP -0.257692443896068 3.43649017566933e-07 NA NA NA hsa-miR-92a-3p PRKCA 2.06460102658973 1.44784291084757e-19 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.177264968474978 0.0028853007950597 NA NA NA hsa-miR-93-3p PRKCA 2.85383869771942 5.64481766902125e-23 -1.04253532292201 0.000330447904822586 mirMAP -0.164593044407034 0.000371570157401047 NA NA NA hsa-miR-129-5p PRKCB -0.524170159980738 0.222582956006346 -3.26032077132529 1.38524824909011e-12 miRanda;mirMAP -0.174875281711081 0.00126377112961492 NA NA NA hsa-miR-141-5p PRKCB 3.81419396518882 3.21977359736126e-18 -3.26032077132529 1.38524824909011e-12 mirMAP -0.448157631252767 6.03056466923945e-21 NA NA NA hsa-miR-16-2-3p PRKCB 2.31623086727196 4.29838149388188e-20 -3.26032077132529 1.38524824909011e-12 mirMAP -0.508156111029493 2.858696818642e-09 NA NA NA hsa-miR-186-5p PRKCB 1.47445398888668 3.0781726595413e-15 -3.26032077132529 1.38524824909011e-12 mirMAP -0.79180135498475 1.36020814670637e-11 NA NA NA hsa-miR-194-5p PRKCB 1.8992998339217 3.76507853301977e-10 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.485081827287577 2.16525492854143e-11 NA NA NA hsa-miR-200b-3p PRKCB 3.78235093249346 3.18343003239465e-14 -3.26032077132529 1.38524824909011e-12 MirTarget -0.450279840251611 3.58923445938153e-27 NA NA NA hsa-miR-200c-3p PRKCB 3.50132673580082 2.42716349086937e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.48715771688849 5.01263551249731e-25 NA NA NA hsa-miR-23a-3p PRKCB 1.00493340843378 2.55313889288924e-08 -3.26032077132529 1.38524824909011e-12 mirMAP -0.422834753714352 0.000810959402297788 NA NA NA hsa-miR-24-3p PRKCB 0.99989036772428 1.35595013650376e-07 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.496540154032259 3.34685620532722e-05 NA NA NA hsa-miR-26b-5p PRKCB 0.885393662798425 3.2116297961629e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.316938073060502 0.0085744560045255 NA NA NA hsa-miR-29b-2-5p PRKCB 0.910668640983475 0.00666655585493488 -3.26032077132529 1.38524824909011e-12 mirMAP -0.34510237827648 3.08410596869229e-07 NA NA NA hsa-miR-30b-5p PRKCB 0.800822374912712 0.000133601914525413 -3.26032077132529 1.38524824909011e-12 mirMAP -0.425134820547528 9.53655468608799e-05 NA NA NA hsa-miR-30c-5p PRKCB 0.778774633108 0.000285599212429136 -3.26032077132529 1.38524824909011e-12 mirMAP -0.468954366973799 1.00031056614682e-05 NA NA NA hsa-miR-30d-3p PRKCB 0.977747550180601 4.3048212205381e-05 -3.26032077132529 1.38524824909011e-12 mirMAP -0.529262539307465 2.03079793114812e-08 NA NA NA hsa-miR-30d-5p PRKCB 0.675423997639582 0.00270618816039773 -3.26032077132529 1.38524824909011e-12 mirMAP -0.603674275615055 1.78624617709124e-09 NA NA NA hsa-miR-330-5p PRKCB 1.15100069700871 4.85551805046014e-07 -3.26032077132529 1.38524824909011e-12 miRanda -0.265696306996962 0.00757029049385514 NA NA NA hsa-miR-335-3p PRKCB 3.08791651139852 5.31309869723517e-12 -3.26032077132529 1.38524824909011e-12 mirMAP -0.330098295724148 1.15037296640229e-11 NA NA NA hsa-miR-335-5p PRKCB 1.77247705492746 2.22457658872091e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.231797522536577 0.000116559468268159 NA NA NA hsa-miR-3607-3p PRKCB 2.68532138541128 5.66716351955047e-14 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.309871089079837 9.51108883796167e-07 NA NA NA hsa-miR-361-5p PRKCB 0.971859117235239 5.30236555707088e-09 -3.26032077132529 1.38524824909011e-12 MirTarget;miRanda;miRNATAP -1.08630383105364 2.58179254217249e-16 NA NA NA hsa-miR-429 PRKCB 4.48815175680773 2.44117492218206e-17 -3.26032077132529 1.38524824909011e-12 MirTarget;miRanda;miRNATAP -0.42521096062837 6.46582126393278e-28 NA NA NA hsa-miR-450b-5p PRKCB 1.69244418548325 1.68064054148881e-10 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.300053601902219 0.00039020696289519 NA NA NA hsa-miR-452-3p PRKCB 2.42521958420768 4.08754552781156e-07 -3.26032077132529 1.38524824909011e-12 mirMAP -0.174939955360914 0.000207028768427815 NA NA NA hsa-miR-484 PRKCB 1.81844463411787 1.82951571230938e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.703163397284051 1.07982697132474e-13 NA NA NA hsa-miR-491-5p PRKCB 0.615770352820862 0.0418295628761654 -3.26032077132529 1.38524824909011e-12 miRanda -0.381404660757775 2.20068611106109e-06 NA NA NA hsa-miR-589-3p PRKCB 2.51971841868825 2.39125940264107e-11 -3.26032077132529 1.38524824909011e-12 mirMAP -0.452218517865859 7.06052991667871e-12 NA NA NA hsa-miR-589-5p PRKCB 1.71990116752371 8.310889042056e-14 -3.26032077132529 1.38524824909011e-12 mirMAP -0.544486942502154 1.22125132593852e-08 NA NA NA hsa-miR-590-3p PRKCB 2.59289455139753 1.03200520972022e-21 -3.26032077132529 1.38524824909011e-12 mirMAP -0.388404821887359 2.22817064825303e-06 NA NA NA hsa-miR-590-5p PRKCB 3.18300989862077 2.06813568597893e-26 -3.26032077132529 1.38524824909011e-12 miRanda -0.553979313426607 1.10231423603006e-14 NA NA NA hsa-miR-7-1-3p PRKCB 1.84950311431067 1.25300363397654e-13 -3.26032077132529 1.38524824909011e-12 mirMAP -0.468511892026853 1.14425525890782e-07 NA NA NA hsa-miR-7-5p PRKCB 2.28980165299999 1.5131097560452e-07 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.171892302839442 0.00201428643670522 NA NA NA hsa-miR-944 PRKCB 2.91186649218281 1.31574753528144e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.173419280691746 6.46731956750453e-06 NA NA NA hsa-let-7a-5p PTGS2 0.618599506841644 2.76973453058748e-05 -2.90239684568393 1.42525690641941e-08 miRNAWalker2_validate -0.601512439487288 0.000499737295101569 NA NA NA hsa-miR-101-3p PTGS2 0.522819989585461 0.00375627731618038 -2.90239684568393 1.42525690641941e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.546453997716925 0.000101495351594311 25109742;26530100;21430074;24759835;26556718;24289600;23644120;24958470;26617722;19133256;24528073;23013439 Enforced expression of miR 101 enhances cisplatin sensitivity in human bladder cancer cells by modulating the cyclooxygenase 2 pathway;Luciferase assay revealed that COX-2 was a direct target for miR-101-3p and overexpression of miR-101-3p decreased cellular COX-2 protein expression; Finally downregulation of miR-101-3p expression and upregulation of COX-2 was found in ESCC specimens from patients with smoking history; Taken together our findings revealed a new post-transcriptional mechanism by which CSE regulated COX-2 expression to favor cancer cell proliferation suggesting miR-101-3p as a potential biomarker and therapeutic target for smoke-related ESCC;Enforced expression of miR 101 inhibits prostate cancer cell growth by modulating the COX 2 pathway in vivo; In this study we investigated the mechanism of microRNA-101 miR-101-regulated COX-2 expression and the therapeutic potential of exogenous miR-101 for COX-2-associated cancer; We found that miR-101 inhibited COX-2 posttranscriptional expression by directly binding to the 3'-untranslated region 3'-UTR of COX-2 mRNA; In conclusion COX-2 is a direct target in miR-101 regulation of posttranscription; These data suggest that exogenous miR-101 may provide a new cancer therapy by directly inhibiting COX-2 expression;MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels;Cyclooxygenase 2 a Potential Therapeutic Target Is Regulated by miR 101 in Esophageal Squamous Cell Carcinoma; This study investigated the effect of miR-101 on ESCC through modulating COX-2 expression in ESCC; The luciferase reporter assay was used to verify COX-2 as a direct target of miR-101; Furthermore COX-2 was shown to be a target of miR-101;The expression of COX-2 in Hela cell was also examined by immunohistochemical staining and the correlation with miR-101 expression was analysed; Thus reduced miR-101 expression could participate in the development of cervical cancer at least partly through loss of inhibition of target gene COX-2 which probably occurs in a relative late phase of carcinogenesis;Expressions of COX 2 PKC α and miR 101 in gastric cancer and their correlations; To investigate the expressions of miR-101 protein kinase C-α PKC-α and cyclooxygenase-2 COX-2 in gastric cancer GC tissue and their correlations; RT-qPCR was used to examine miR-101 expression and Western blotting employed to detect PKC-α and COX-2 expressions in 57 cases of gastric cancer tissues and paired normal gastric mucosal tissues; The gastric cancer tissues showed a significantly lower miR-101 expression Z=6.102 P<0.05 but significantly higher expressions of COX-2 Z=14.436 P<0.05 and PKC-α Z=6.955 P<0.05 than the normal gastric tissues; PKC-α expression was positively correlated r=0.531 P<0.05 and miR-101 expression negatively correlated r=-0.627 P<0.05 with COX-2 expression in gastric cancer tissues; miR-101 PKC-α and COX-2 all play a role in the tumorigenesis and progression of gastric cancer; miR-101 and PKC-α might be new potential therapeutic targets for inhibiting COX-2 in gastric cancer;Interestingly cyclooxygenase-2 inhibition by aspirin or celecoxib abrogated IL-1β-mediated repression of miR-101 and IL-1β-mediated activation of Lin28B along with their stimulatory effects on NSCLC cell proliferation and migration;Immunohistochemistry was performed to assess protein expression of the miR-101 target gene COX-2; Overexpression of miR-101 decreased expression of its target gene Cox-2 and inhibited proliferation and invasion and promoted apoptosis to suppress tumorigenicity;MiR 101 downregulation is involved in cyclooxygenase 2 overexpression in human colon cancer cells; In this paper we report the inverse correlation between COX-2 and miR-101 expression in colon cancer cell lines and we demonstrated in vitro the direct inhibition of COX-2 mRNA translation mediated by miR-101; These findings provide a novel molecular insight in the modulation of COX-2 at post-transcriptional level by miR-101 and strengthen the observation that miRNAs are highly implicated in the control of gene expression; An impairment of miR-101 levels could represent one of the leading causes of COX-2 overexpression in colon cancer cells;Roles of MiR 101 and its target gene Cox 2 in early diagnosis of cervical cancer in Uygur women; Use of down-regulation of miR-101 and up-regulation of Cox-2 as markers may play a role in early diagnosis of cervical cancer in Uygur women;Downregulation of miR 101 in gastric cancer correlates with cyclooxygenase 2 overexpression and tumor growth; Here we characterize miR-101 expression and its role in the regulation of COX-2 expression which in turn will provide us with additional insights into the potential therapeutic benefits of exogenous miR-101 for treatment of gastric cancer; We also found an inverse correlation between miR-101 and COX-2 expression in both gastric cancer specimens and cell lines; One possible mechanism of interaction is that miR-101 inhibited COX-2 expression by directly binding to the 3'-UTR of COX-2 mRNA; These results collectively indicate that miR-101 may function as a tumor suppressor in gastric cancer with COX-2 as a direct target ;;;;;tumorigenesis;progression;tumorigenesis;;;;; bladder cancer;esophageal cancer;prostate cancer;liver cancer;esophageal cancer;cervical and endocervical cancer;gastric cancer;lung cancer;cervical and endocervical cancer;colon cancer;cervical and endocervical cancer;gastric cancer hsa-miR-128-3p PTGS2 1.63756041666078 6.79626586407187e-14 -2.90239684568393 1.42525690641941e-08 miRNAWalker2_validate -0.578050829406664 2.09770018104606e-07 NA NA NA hsa-miR-16-2-3p PTGS2 2.31623086727196 4.29838149388188e-20 -2.90239684568393 1.42525690641941e-08 mirMAP -0.46791999347385 7.95786077904086e-07 NA NA NA hsa-miR-16-5p PTGS2 1.75824877145857 1.68592440033108e-16 -2.90239684568393 1.42525690641941e-08 miRNAWalker2_validate;miRTarBase -0.554848165642294 1.04010485470405e-06 25196524;24759835 Artesunate induces apoptosis of bladder cancer cells by miR 16 regulation of COX 2 expression; Cyclooxygenase-2 COX-2 and miR-16 expression levels were determined with real-time PCR; ART efficiently inhibited orthotopic tumor growth in the bladder cancer rat which is accompanied with an increase of miR-16 expression and a decrease of COX-2 expression; ART significantly increased miR-16 expression and decreased the expression of COX-2 and the production of PGE2; More importantly down-regulation of miR-16 expression could reverse the effect of ART on apoptosis and COX-2 expression in bladder cells; In conclusion ART can elicit an anti-tumor effect against bladder cancer by up-regulation of miR-16 expression which resulted in the decrease of COX-2 expression and PGE2 production;MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels ; bladder cancer;liver cancer hsa-miR-17-5p PTGS2 3.2710598467455 9.93128340539455e-27 -2.90239684568393 1.42525690641941e-08 miRNAWalker2_validate -0.439002346001654 8.79363659893768e-09 NA NA NA hsa-miR-3065-5p PTGS2 2.74629919868982 1.86846589298284e-08 -2.90239684568393 1.42525690641941e-08 mirMAP -0.19694785405148 0.00151389583849892 NA NA NA hsa-miR-32-3p PTGS2 2.02436999565685 5.94091197945307e-09 -2.90239684568393 1.42525690641941e-08 mirMAP -0.416074131865064 2.2338056662955e-07 NA NA NA hsa-miR-34a-3p PTGS2 1.75590866103657 8.02801510630657e-09 -2.90239684568393 1.42525690641941e-08 MirTarget -0.269119883838932 0.00296530834428862 23349340 Furthermore restoration of miR-34a indirectly reduced cyclooxygenase-2 COX-2 expression lung squamous cell cancer hsa-miR-362-3p PTGS2 2.0756816987665 3.89026064579331e-12 -2.90239684568393 1.42525690641941e-08 miRanda -0.418318326271494 6.73102985152392e-07 NA NA NA hsa-miR-374a-5p PTGS2 0.484615721953736 0.0042981729815149 -2.90239684568393 1.42525690641941e-08 mirMAP -0.484847743904815 0.00125076246708935 NA NA NA hsa-miR-429 PTGS2 4.48815175680773 2.44117492218206e-17 -2.90239684568393 1.42525690641941e-08 miRanda;miRNATAP -0.167040017835344 0.000237599042747652 NA NA NA hsa-miR-450b-5p PTGS2 1.69244418548325 1.68064054148881e-10 -2.90239684568393 1.42525690641941e-08 mirMAP -0.301882283798367 0.00120683021351569 NA NA NA hsa-miR-576-5p PTGS2 2.20467023993664 3.4053475193793e-19 -2.90239684568393 1.42525690641941e-08 mirMAP -0.438530428113169 7.0958786253322e-06 NA NA NA hsa-miR-624-5p PTGS2 1.47043111118159 8.25080691741182e-09 -2.90239684568393 1.42525690641941e-08 MirTarget -0.478116819514548 1.92135381652596e-06 NA NA NA hsa-miR-652-3p PTGS2 2.16948080686801 4.80670949499399e-18 -2.90239684568393 1.42525690641941e-08 miRNAWalker2_validate -0.41075486053674 2.00218153721365e-05 NA NA NA hsa-miR-7-1-3p PTGS2 1.84950311431067 1.25300363397654e-13 -2.90239684568393 1.42525690641941e-08 MirTarget -0.474224364910237 1.1603900406246e-06 NA NA NA hsa-miR-708-5p PTGS2 3.38051631555486 5.12590198690777e-18 -2.90239684568393 1.42525690641941e-08 MirTarget -0.219131957644256 0.000378564332135072 NA NA NA hsa-miR-744-5p PTGS2 1.48254348878737 3.23019501613577e-09 -2.90239684568393 1.42525690641941e-08 miRNAWalker2_validate -0.455798059476578 3.65200078533447e-06 NA NA NA hsa-let-7c-5p PTK2 -2.07847142524506 5.51224567263294e-09 0.31431677285734 0.0476564958514266 miRNAWalker2_validate -0.113450604453773 5.21892454913942e-08 NA NA NA hsa-miR-193a-3p PTK2 1.60460546928078 2.86169793322984e-07 0.31431677285734 0.0476564958514266 miRNAWalker2_validate;miRanda -0.109883142484797 4.78130386152767e-06 NA NA NA hsa-miR-374b-5p RAC1 0.0654362503857184 0.722673188879465 0.221936454340431 0.051549220692643 mirMAP -0.101573831955509 0.000746852128506454 NA NA NA hsa-miR-375 RAC2 1.13910305294079 0.0512283522214186 0.0225400305534329 0.947191555182511 miRanda -0.111974015284125 5.98476138848745e-05 NA NA NA hsa-miR-186-5p SHC2 1.47445398888668 3.0781726595413e-15 -1.55018578792841 2.19238221574848e-05 miRNAWalker2_validate -0.486338062930925 1.3091161584858e-07 NA NA NA hsa-miR-330-3p SPHK1 0.876747334239085 0.00073709016089703 0.88272290531505 0.0549040779437606 miRNATAP -0.580272187401296 4.02055527589273e-12 NA NA NA hsa-miR-484 SPHK1 1.81844463411787 1.82951571230938e-15 0.88272290531505 0.0549040779437606 miRNAWalker2_validate -0.315664190371172 0.000829712011380627 NA NA NA hsa-miR-130a-3p SRC 2.02021855058359 1.26427102520415e-11 0.570460331165611 0.0110129276753055 mirMAP -0.142068870145428 6.08308617638817e-05 NA NA NA hsa-miR-132-5p SRC 0.0013490685505323 0.995763495755809 0.570460331165611 0.0110129276753055 MirTarget -0.220312723053475 6.86379054233987e-07 NA NA NA hsa-miR-193a-3p SRC 1.60460546928078 2.86169793322984e-07 0.570460331165611 0.0110129276753055 mirMAP -0.17664648706064 1.96273303635261e-07 NA NA NA hsa-miR-221-5p SRC -0.745357436702497 0.081887809839391 0.570460331165611 0.0110129276753055 MirTarget -0.114257533151616 8.97086699137357e-06 NA NA NA hsa-miR-2355-5p SRC 1.32510310704724 8.25139516692683e-07 0.570460331165611 0.0110129276753055 mirMAP -0.172520855037043 1.46783203304486e-05 NA NA NA hsa-miR-338-5p SRC -0.577691606146419 0.0472212680542825 0.570460331165611 0.0110129276753055 PITA;miRNATAP -0.195583102051808 1.56647881831225e-07 NA NA NA hsa-miR-1-3p VEGFA -3.48370702447685 1.98579484008516e-13 0.471653090802802 0.0989904385682923 MirTarget -0.202978528176548 1.57292170658149e-13 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-133a-3p VEGFA -3.38501431117712 1.32336729742128e-13 0.471653090802802 0.0989904385682923 miRNAWalker2_validate -0.190996958246616 2.70660605752725e-11 NA NA NA hsa-miR-134-5p VEGFA 0.141163006984518 0.655334296084178 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase;MirTarget -0.180227374251871 3.58435465670397e-05 NA NA NA hsa-miR-145-5p VEGFA -1.55259331973517 9.97889123247165e-07 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase -0.277645238248207 4.72205041776188e-11 24966896;24781864;22472569 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically ;metastasis; bladder cancer;thyroid cancer;sarcoma hsa-miR-150-5p VEGFA -0.105827294491332 0.799351458244375 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase -0.164137084593398 6.0374913950269e-07 NA NA NA hsa-miR-195-5p VEGFA -1.44753678070504 8.70594292149271e-09 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase;MirTarget -0.21863878149299 5.11037236008283e-05 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA 0.592984035153911 0.0674836634175293 0.471653090802802 0.0989904385682923 miRanda;miRNATAP -0.205612739501636 1.1489897892283e-06 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA 0.218704279044827 0.519493319158441 0.471653090802802 0.0989904385682923 miRanda -0.175899050515122 1.43171320791549e-05 NA NA NA hsa-miR-29a-3p VEGFA -0.35074463683376 0.161238718982428 0.471653090802802 0.0989904385682923 MirTarget -0.313847513848792 9.68544057650496e-09 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-342-3p VEGFA 1.49115144672245 1.43879249744621e-07 0.471653090802802 0.0989904385682923 miRanda;miRNATAP -0.166390639835536 0.000539599594707828 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-374b-5p VEGFA 0.0654362503857184 0.722673188879465 0.471653090802802 0.0989904385682923 MirTarget -0.254824056474554 0.000792850845311603 NA NA NA hsa-miR-655-3p VEGFA 0.485339318272148 0.137014658258732 0.471653090802802 0.0989904385682923 MirTarget -0.164823030617487 0.000126415331270495 NA NA NA