miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106b-5p APC 1.47447672652218 1.32004094930462e-13 -0.81362334855622 2.34409310508842e-09 miRNAWalker2_validate;miRTarBase -0.160151734491997 2.27862007699814e-07 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-142-3p APC 3.98476449801341 1.56256182021111e-35 -0.81362334855622 2.34409310508842e-09 MirTarget;PITA;miRanda;miRNATAP -0.129581416245212 5.1300823863087e-13 NA NA NA hsa-miR-182-5p APC 3.21839823004635 5.13049145201115e-39 -0.81362334855622 2.34409310508842e-09 MirTarget -0.121845418493389 2.17323154862301e-07 NA NA NA hsa-miR-186-5p APC 0.852175445703945 6.88885738584309e-10 -0.81362334855622 2.34409310508842e-09 miRNAWalker2_validate -0.232136880640038 3.271825543298e-07 NA NA NA hsa-miR-193a-3p APC 0.549173467360291 0.0319030569365466 -0.81362334855622 2.34409310508842e-09 miRanda -0.120903071477339 6.68461456828318e-06 NA NA NA hsa-miR-21-5p APC 4.38165933891779 1.52536633902505e-92 -0.81362334855622 2.34409310508842e-09 miRNAWalker2_validate -0.144937162471473 1.26897892677296e-09 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-210-3p APC 4.89285936864822 4.81769290932762e-28 -0.81362334855622 2.34409310508842e-09 miRNAWalker2_validate -0.110530227622043 1.49305331878995e-17 NA NA NA hsa-miR-450b-5p APC 1.69248953402469 1.96052058003353e-07 -0.81362334855622 2.34409310508842e-09 miRNATAP -0.131524767664808 6.18647514096151e-10 NA NA NA hsa-miR-589-3p APC 1.34253876396688 1.84935927493927e-05 -0.81362334855622 2.34409310508842e-09 MirTarget -0.107516350519092 1.76806883201475e-07 NA NA NA hsa-miR-590-3p APC 0.83851360565783 0.00129224433453587 -0.81362334855622 2.34409310508842e-09 PITA;miRanda;mirMAP;miRNATAP -0.206678927804611 4.70677024968128e-13 NA NA NA hsa-miR-7-1-3p APC 2.61364240402652 1.98959237815786e-32 -0.81362334855622 2.34409310508842e-09 MirTarget -0.110663740061812 9.37432693363158e-05 NA NA NA hsa-let-7a-5p APC2 -1.37014061604018 3.11451492971224e-14 1.13734300868111 0.000124925970306742 TargetScan -0.464919515060219 2.14185938273543e-10 NA NA NA hsa-miR-2110 APC2 -1.92124860612475 1.1464887721828e-12 1.13734300868111 0.000124925970306742 MirTarget;miRNATAP -0.179829115815386 0.000321446020349742 NA NA NA hsa-miR-221-5p APC2 -2.2173523967387 1.8954728277084e-09 1.13734300868111 0.000124925970306742 mirMAP -0.100180944873868 0.00794329184829682 NA NA NA hsa-miR-664a-5p APC2 -0.0936480603578111 0.662274905077117 1.13734300868111 0.000124925970306742 mirMAP -0.184305709745507 0.00537252679600084 NA NA NA hsa-miR-335-5p AXIN1 -0.466533891325811 0.0676987038122831 0.529388216277775 2.72687033050374e-05 miRNAWalker2_validate -0.118760864503714 3.03238519983658e-06 NA NA NA hsa-let-7g-3p AXIN2 2.38336858943031 4.8771148585792e-17 -1.4952232670323 9.5322330602006e-08 MirTarget -0.114428501062786 0.0101214806434388 NA NA NA hsa-miR-15a-5p AXIN2 1.62575353599172 1.55312121019827e-19 -1.4952232670323 9.5322330602006e-08 MirTarget;miRNATAP -0.217041543063005 0.00198973394153194 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-16-2-3p AXIN2 0.503964803530872 0.0263648405197492 -1.4952232670323 9.5322330602006e-08 mirMAP -0.137750843587701 0.028341150477739 NA NA NA hsa-miR-16-5p AXIN2 0.749619098384047 4.11649450706988e-06 -1.4952232670323 9.5322330602006e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.200486504280819 0.0126683953593233 NA NA NA hsa-miR-221-3p AXIN2 -0.0986794612964683 0.654454148658401 -1.4952232670323 9.5322330602006e-08 miRNATAP -0.192459747047839 0.00122885278253862 NA NA NA hsa-miR-222-3p AXIN2 0.0327210697409583 0.881937768109611 -1.4952232670323 9.5322330602006e-08 miRNATAP -0.248218141503819 2.9034801887089e-05 NA NA NA hsa-miR-29a-5p AXIN2 1.89519956688438 1.03453349363915e-11 -1.4952232670323 9.5322330602006e-08 MirTarget -0.133336967418569 0.0153824320015045 NA NA NA hsa-miR-424-5p AXIN2 1.26485330287919 6.1498991028257e-06 -1.4952232670323 9.5322330602006e-08 MirTarget;miRNATAP -0.197607378372592 1.81497593184144e-05 NA NA NA hsa-miR-590-3p AXIN2 0.83851360565783 0.00129224433453587 -1.4952232670323 9.5322330602006e-08 MirTarget;PITA;miRanda;miRNATAP -0.263625743981492 1.01810938870619e-05 NA NA NA hsa-miR-103a-3p BTRC 0.538497806383155 1.88134691850591e-05 0.0480417791180399 0.622827696093888 MirTarget;miRNATAP -0.113248753589541 0.00155888979006598 NA NA NA hsa-miR-16-5p BTRC 0.749619098384047 4.11649450706988e-06 0.0480417791180399 0.622827696093888 miRNAWalker2_validate;MirTarget;miRNATAP -0.107405552913543 8.38188422898451e-05 NA NA NA hsa-miR-342-3p BTRC -0.128691966564961 0.561034080130801 0.0480417791180399 0.622827696093888 mirMAP -0.136089179349028 6.98648472032989e-12 NA NA NA hsa-miR-195-3p CACYBP -1.33068822339418 6.65427393047357e-09 0.791565361368688 9.64825586974023e-09 mirMAP -0.220516523952641 2.60239199366134e-16 NA NA NA hsa-miR-30a-3p CACYBP -2.54042202792785 2.9111625410859e-18 0.791565361368688 9.64825586974023e-09 MirTarget -0.160894558878934 7.25748249407963e-15 NA NA NA hsa-miR-320a CACYBP -0.961144925954715 1.62478794429204e-08 0.791565361368688 9.64825586974023e-09 miRanda -0.224979010070152 1.19014895828257e-09 NA NA NA hsa-miR-130b-5p CAMK2A 1.53645187062942 1.10498816261505e-08 -1.98450244020379 1.79267707874172e-10 mirMAP -0.249529328474107 2.6951403846001e-06 NA NA NA hsa-miR-148b-5p CAMK2A 1.39335695292409 2.13220380550073e-07 -1.98450244020379 1.79267707874172e-10 mirMAP -0.282914973757321 1.06096270828889e-05 NA NA NA hsa-miR-15b-3p CAMK2A 0.804736041893915 0.000400279611457186 -1.98450244020379 1.79267707874172e-10 mirMAP -0.328424579288596 9.92187913064475e-07 NA NA NA hsa-miR-19b-1-5p CAMK2A 1.71217036351784 3.28561659177495e-12 -1.98450244020379 1.79267707874172e-10 mirMAP -0.342392712947742 2.74781586124706e-07 NA NA NA hsa-miR-21-3p CAMK2A 2.54206008030157 1.11598785398763e-30 -1.98450244020379 1.79267707874172e-10 MirTarget -0.324653187186303 1.25884069603633e-07 NA NA NA hsa-miR-25-3p CAMK2A 0.361927330834176 0.0163670566170988 -1.98450244020379 1.79267707874172e-10 MirTarget -0.431018251677991 9.57991045458072e-06 NA NA NA hsa-miR-331-3p CAMK2A 0.648841966086413 0.00576420872256978 -1.98450244020379 1.79267707874172e-10 MirTarget -0.156192127017353 0.0121281335990064 NA NA NA hsa-miR-429 CAMK2A 2.3794516574089 1.72813419703734e-13 -1.98450244020379 1.79267707874172e-10 miRNATAP -0.197000677489517 3.43288481731808e-05 NA NA NA hsa-miR-582-3p CAMK2A 1.70881364237226 1.26508456000083e-06 -1.98450244020379 1.79267707874172e-10 mirMAP -0.125824585974862 0.00211118483675127 NA NA NA hsa-miR-625-5p CAMK2A 1.38208523187596 6.28473801440755e-07 -1.98450244020379 1.79267707874172e-10 mirMAP -0.178916439089146 0.00214748454110243 NA NA NA hsa-miR-7-1-3p CAMK2A 2.61364240402652 1.98959237815786e-32 -1.98450244020379 1.79267707874172e-10 MirTarget -0.321459504611602 6.82264507997045e-07 NA NA NA hsa-miR-92a-3p CAMK2A -0.136362762339122 0.493412263619364 -1.98450244020379 1.79267707874172e-10 MirTarget -0.255396586802194 0.000533601187550464 NA NA NA hsa-miR-92b-3p CAMK2A 0.0478787637665503 0.831716894621477 -1.98450244020379 1.79267707874172e-10 MirTarget -0.210822693788893 0.00120251365209552 NA NA NA hsa-miR-24-3p CAMK2B -0.0357874587555003 0.785865078836504 1.36872036948597 0.01479821016335 MirTarget -0.416437345149369 0.0381047524953316 NA NA NA hsa-miR-29a-3p CAMK2B 0.101650412194573 0.573201097011668 1.36872036948597 0.01479821016335 mirMAP -0.56719932512718 8.45582460317295e-05 NA NA NA hsa-miR-185-5p CAMK2D 1.14291034858482 2.95777119743491e-13 -0.0925103709748827 0.592532241871341 miRNATAP -0.147713514689931 0.0030330941127861 NA NA NA hsa-miR-197-3p CAMK2D -1.2979654860824 1.79649132641813e-07 -0.0925103709748827 0.592532241871341 miRNATAP -0.123098308888499 9.0478478122662e-05 NA NA NA hsa-miR-27a-3p CAMK2D 0.433402568013802 0.00737164631768323 -0.0925103709748827 0.592532241871341 miRNATAP -0.192414655713063 9.36146270486912e-05 NA NA NA hsa-miR-320b CAMK2D 0.226640952564488 0.378818692487242 -0.0925103709748827 0.592532241871341 miRanda -0.114060959724978 0.000213926434734232 NA NA NA hsa-miR-342-3p CAMK2D -0.128691966564961 0.561034080130801 -0.0925103709748827 0.592532241871341 miRanda -0.171438694927923 1.61176050466419e-06 NA NA NA hsa-miR-484 CAMK2D -0.228576985124486 0.244112867390855 -0.0925103709748827 0.592532241871341 miRNAWalker2_validate -0.132887201871556 0.00107690362512265 NA NA NA hsa-miR-582-5p CAMK2D 1.08286181406653 0.00149040450161757 -0.0925103709748827 0.592532241871341 mirMAP -0.160421826572603 5.66795867474856e-12 NA NA NA hsa-miR-590-3p CAMK2D 0.83851360565783 0.00129224433453587 -0.0925103709748827 0.592532241871341 miRanda;mirMAP -0.128986833028759 0.000392008636157636 NA NA NA hsa-miR-708-3p CAMK2D 3.43841959417743 4.40027692981683e-28 -0.0925103709748827 0.592532241871341 mirMAP -0.108800716220179 4.15668797368357e-05 NA NA NA hsa-miR-193a-5p CAMK2G -1.15938257046946 2.61709321247277e-08 0.0793958703286402 0.517802682824221 miRNATAP -0.108006937809376 4.88499177473994e-05 NA NA NA hsa-miR-106a-5p CCND1 1.3902608059488 6.07931522284525e-05 -0.295767629587253 0.255400743295204 MirTarget;miRNATAP -0.247441760563832 4.58943715400631e-11 NA NA NA hsa-miR-106b-5p CCND1 1.47447672652218 1.32004094930462e-13 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.261384817974007 7.4979419817232e-06 NA NA NA hsa-miR-142-3p CCND1 3.98476449801341 1.56256182021111e-35 -0.295767629587253 0.255400743295204 miRanda -0.119299030581201 0.000532277158339159 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-15a-5p CCND1 1.62575353599172 1.55312121019827e-19 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.199069637483131 0.0019294787514794 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 -1.25935038177398 1.83460220856901e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.303824360423629 3.25741318048184e-06 NA NA NA hsa-miR-16-1-3p CCND1 1.50034693398929 6.63958242991125e-10 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.249107447749185 3.23141967346606e-05 22922827;18483394 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ; sarcoma;lymphoma hsa-miR-16-5p CCND1 0.749619098384047 4.11649450706988e-06 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.371885624299403 3.21606546730418e-07 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-17-5p CCND1 2.07078488653279 2.77403038572568e-19 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.313758634258834 1.59321495552009e-10 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-183-5p CCND1 2.39247234736657 3.92444525331999e-21 -0.295767629587253 0.255400743295204 miRNAWalker2_validate -0.106624472349674 0.0183817725314783 NA NA NA hsa-miR-186-5p CCND1 0.852175445703945 6.88885738584309e-10 -0.295767629587253 0.255400743295204 mirMAP -0.377477028673122 1.06268066352005e-05 NA NA NA hsa-miR-193a-3p CCND1 0.549173467360291 0.0319030569365466 -0.295767629587253 0.255400743295204 MirTarget;PITA;miRanda -0.190950932146342 0.000161171890671323 NA NA NA hsa-miR-193b-3p CCND1 1.10444771306846 0.000822888533401377 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget -0.147999411883792 3.70620495015026e-05 27071318;20655737;20304954;21893020;26129688 MicroRNA 193b inhibits the proliferation migration and invasion of gastric cancer cells via targeting cyclin D1; Further mechanism study indicated that CCND1 was a direct target of miR-193b in GC;CCND1 and ETS1 were revealed to be regulated by miR-193b directly;MicroRNA 193b represses cell proliferation and regulates cyclin D1 in melanoma; Overexpression of miR-193b in Malme-3M cells down-regulated CCND1 mRNA and protein by > or = 50%; A luciferase reporter assay confirmed that miR-193b directly regulates CCND1 by binding to the 3'untranslated region of CCND1 mRNA; These studies indicate that miR-193b represses cell proliferation and regulates CCND1 expression and suggest that dysregulation of miR-193b may play an important role in melanoma development;In a previous study we reported that miR-193b represses cell proliferation and regulates cyclin D1 in melanoma cells suggesting that miR-193b could act as a tumor suppressor;Epigenetically altered miR 193b targets cyclin D1 in prostate cancer; It has been suggested that miR-193b targets cyclin D1 in several malignancies; Here our aim was to determine if miR-193b targets cyclin D1 in prostate cancer; Furthermore the PC cell lines 22Rv1 and VCaP which express low levels of miR-193b and high levels of CCND1 showed significant growth retardation when treated with a CDK4/6 inhibitor; In contrast the inhibitor had no effect on the growth of PC-3 and DU145 cells with high miR-193b and low CCND1 expression; Taken together our data demonstrate that miR-193b targets cyclin D1 in prostate cancer ;;;; gastric cancer;liver cancer;melanoma;melanoma;prostate cancer hsa-miR-19a-3p CCND1 2.11776595911517 7.07663078397156e-10 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;miRNATAP -0.21539529985992 9.86203433305448e-08 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 1.71217036351784 3.28561659177495e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.301713494105536 2.89182846291565e-08 NA NA NA hsa-miR-19b-3p CCND1 2.10868505662119 5.40846613768389e-17 -0.295767629587253 0.255400743295204 miRNATAP -0.179773518063806 0.000197856717032667 NA NA NA hsa-miR-20a-5p CCND1 2.64649625616975 5.1469418982085e-27 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.237160136465301 1.84669386058676e-07 NA NA NA hsa-miR-20b-5p CCND1 1.35770573270947 0.00260808530013016 -0.295767629587253 0.255400743295204 MirTarget;miRNATAP -0.179107595068828 5.65966117118738e-11 NA NA NA hsa-miR-340-5p CCND1 -0.668005790839634 0.018612920432186 -0.295767629587253 0.255400743295204 mirMAP -0.109708554855455 0.0244642233491157 NA NA NA hsa-miR-365a-3p CCND1 0.0132777124336201 0.953597412537431 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.193166924738263 0.000234492957903034 NA NA NA hsa-miR-374a-5p CCND1 -0.197027254874826 0.298080902192861 -0.295767629587253 0.255400743295204 MirTarget -0.313785702713176 9.54081268797886e-06 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression progression colon cancer hsa-miR-374b-5p CCND1 0.474691035780475 0.0109217471394203 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget -0.26116225100222 0.00011561978488339 NA NA NA hsa-miR-425-5p CCND1 1.21659524959201 8.01126418494715e-09 -0.295767629587253 0.255400743295204 miRNAWalker2_validate -0.245575402525843 1.03844251357893e-05 NA NA NA hsa-miR-589-3p CCND1 1.34253876396688 1.84935927493927e-05 -0.295767629587253 0.255400743295204 MirTarget -0.130907472589194 0.000793150025378685 NA NA NA hsa-miR-590-3p CCND1 0.83851360565783 0.00129224433453587 -0.295767629587253 0.255400743295204 mirMAP -0.182941292569374 0.000856336828554768 NA NA NA hsa-miR-7-1-3p CCND1 2.61364240402652 1.98959237815786e-32 -0.295767629587253 0.255400743295204 mirMAP -0.126631989614995 0.0179507478544937 NA NA NA hsa-miR-769-3p CCND1 0.452126659761753 0.0748150639143322 -0.295767629587253 0.255400743295204 mirMAP -0.142316943866129 0.00276805281261241 NA NA NA hsa-miR-92a-3p CCND1 -0.136362762339122 0.493412263619364 -0.295767629587253 0.255400743295204 miRNAWalker2_validate -0.337251172229938 1.62058605849004e-08 NA NA NA hsa-miR-93-5p CCND1 1.50844106515467 1.83836866996875e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget;miRNATAP -0.320397820083252 2.84014735439528e-09 NA NA NA hsa-miR-942-5p CCND1 -0.0372813055050076 0.870631058767894 -0.295767629587253 0.255400743295204 MirTarget -0.177314558661089 0.000979800060419363 NA NA NA hsa-miR-106a-5p CCND2 1.3902608059488 6.07931522284525e-05 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.149132151233025 1.88464236882735e-05 NA NA NA hsa-miR-106b-5p CCND2 1.47447672652218 1.32004094930462e-13 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.383655587509124 2.65429916887189e-13 NA NA NA hsa-miR-130b-5p CCND2 1.53645187062942 1.10498816261505e-08 -1.64140990579885 1.49666938681079e-12 mirMAP -0.268032769997331 9.22343432530747e-12 NA NA NA hsa-miR-141-3p CCND2 3.36993755486106 5.42939251147195e-32 -1.64140990579885 1.49666938681079e-12 MirTarget;TargetScan -0.239914655059016 6.4654039095017e-12 NA NA NA hsa-miR-151a-3p CCND2 0.665271883054405 0.000281673348137154 -1.64140990579885 1.49666938681079e-12 mirMAP -0.279142680983949 2.60564778780149e-06 NA NA NA hsa-miR-15a-5p CCND2 1.62575353599172 1.55312121019827e-19 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.158338209854594 0.00711668272045409 NA NA NA hsa-miR-16-5p CCND2 0.749619098384047 4.11649450706988e-06 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRNATAP -0.135197503151631 0.0448488951166271 NA NA NA hsa-miR-17-5p CCND2 2.07078488653279 2.77403038572568e-19 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.365048259055278 1.61934056872758e-16 NA NA NA hsa-miR-182-5p CCND2 3.21839823004635 5.13049145201115e-39 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.373145719566719 1.32597677460149e-21 NA NA NA hsa-miR-183-5p CCND2 2.39247234736657 3.92444525331999e-21 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.410520271082553 1.11291256348519e-25 NA NA NA hsa-miR-185-5p CCND2 1.14291034858482 2.95777119743491e-13 -1.64140990579885 1.49666938681079e-12 MirTarget;miRNATAP -0.23940712387784 0.000484175543966546 NA NA NA hsa-miR-186-5p CCND2 0.852175445703945 6.88885738584309e-10 -1.64140990579885 1.49666938681079e-12 mirMAP;miRNATAP -0.357370184588874 5.14493635358813e-06 NA NA NA hsa-miR-191-5p CCND2 0.343645878547116 0.0668114086143391 -1.64140990579885 1.49666938681079e-12 MirTarget -0.19767765908675 0.000750401585158583 NA NA NA hsa-miR-19a-3p CCND2 2.11776595911517 7.07663078397156e-10 -1.64140990579885 1.49666938681079e-12 MirTarget;miRNATAP -0.167455065978335 6.56621464464812e-06 NA NA NA hsa-miR-19b-3p CCND2 2.10868505662119 5.40846613768389e-17 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.19157786848984 1.39328108679414e-05 NA NA NA hsa-miR-200a-3p CCND2 3.14766878548496 1.32850889777422e-21 -1.64140990579885 1.49666938681079e-12 MirTarget -0.173744823500602 6.53232158053391e-08 NA NA NA hsa-miR-20a-5p CCND2 2.64649625616975 5.1469418982085e-27 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.28367508352758 5.6750334332974e-12 NA NA NA hsa-miR-21-3p CCND2 2.54206008030157 1.11598785398763e-30 -1.64140990579885 1.49666938681079e-12 mirMAP -0.212907340098529 4.00646631535515e-06 NA NA NA hsa-miR-2355-3p CCND2 1.10676344164715 6.24068383465151e-06 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.221166273655799 1.96123873319489e-06 NA NA NA hsa-miR-28-5p CCND2 1.19639196514745 4.59365801666536e-18 -1.64140990579885 1.49666938681079e-12 miRanda -0.289410618824274 0.00017592467355866 NA NA NA hsa-miR-301a-3p CCND2 2.70198002906399 1.56420889710984e-14 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.265639128307335 3.9945374923581e-13 NA NA NA hsa-miR-320b CCND2 0.226640952564488 0.378818692487242 -1.64140990579885 1.49666938681079e-12 mirMAP;miRNATAP -0.123605256651271 0.00373003525561283 NA NA NA hsa-miR-324-3p CCND2 -0.0774700133118458 0.689226297032231 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.276159423764137 9.9462768745637e-07 NA NA NA hsa-miR-331-5p CCND2 0.578237334664505 0.00131211239210882 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.275952758002927 9.36107182529594e-06 NA NA NA hsa-miR-429 CCND2 2.3794516574089 1.72813419703734e-13 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.209322906628109 2.95963655497587e-09 NA NA NA hsa-miR-450b-5p CCND2 1.69248953402469 1.96052058003353e-07 -1.64140990579885 1.49666938681079e-12 MirTarget;PITA;miRNATAP -0.145422700655101 8.53356735526403e-05 NA NA NA hsa-miR-501-5p CCND2 0.411357595674671 0.10435288464149 -1.64140990579885 1.49666938681079e-12 PITA;mirMAP;miRNATAP -0.144149908130612 0.000856140982438327 NA NA NA hsa-miR-503-5p CCND2 1.97129438815516 2.1704434283035e-09 -1.64140990579885 1.49666938681079e-12 MirTarget -0.132569636435255 4.69239346000773e-05 25860935 We then identified two targets of miR-503 CCND2 and CCND3 breast cancer hsa-miR-550a-5p CCND2 0.59977150019756 0.0314775340172755 -1.64140990579885 1.49666938681079e-12 MirTarget -0.220699899618513 1.33146855439522e-08 NA NA NA hsa-miR-589-3p CCND2 1.34253876396688 1.84935927493927e-05 -1.64140990579885 1.49666938681079e-12 mirMAP -0.194613807523332 3.68596504229146e-08 NA NA NA hsa-miR-590-3p CCND2 0.83851360565783 0.00129224433453587 -1.64140990579885 1.49666938681079e-12 miRanda;mirMAP -0.133052154455084 0.00820830741469702 NA NA NA hsa-miR-590-5p CCND2 2.07441240363458 4.95240551694843e-14 -1.64140990579885 1.49666938681079e-12 mirMAP -0.258740782004531 5.16823341358779e-08 NA NA NA hsa-miR-660-5p CCND2 2.04875198906126 1.08269480928897e-17 -1.64140990579885 1.49666938681079e-12 mirMAP -0.145565210932688 0.00131443056428649 NA NA NA hsa-miR-7-1-3p CCND2 2.61364240402652 1.98959237815786e-32 -1.64140990579885 1.49666938681079e-12 mirMAP -0.259792711431322 7.83559584811719e-08 NA NA NA hsa-miR-877-5p CCND2 -0.370234513208225 0.20670834111988 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.150269749089241 5.7135351515868e-05 NA NA NA hsa-miR-93-5p CCND2 1.50844106515467 1.83836866996875e-12 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.414585687663892 1.04746846150745e-17 NA NA NA hsa-miR-96-5p CCND2 3.0381097138467 4.40362891630201e-24 -1.64140990579885 1.49666938681079e-12 TargetScan;miRNATAP -0.357833634781266 1.13611538125112e-20 NA NA NA hsa-miR-320b CCND3 0.226640952564488 0.378818692487242 -0.858556164090156 9.93688486289821e-06 miRanda -0.106740567141186 0.00235090988932412 NA NA NA hsa-miR-421 CCND3 0.170525317701774 0.535277026680289 -0.858556164090156 9.93688486289821e-06 PITA;miRanda -0.120402813664522 0.000730915299268324 NA NA NA hsa-miR-96-5p CCND3 3.0381097138467 4.40362891630201e-24 -0.858556164090156 9.93688486289821e-06 TargetScan -0.12470872406597 0.000146574618288945 NA NA NA hsa-miR-140-5p CHD8 0.669142684153918 0.000335928403032308 0.131298838238113 0.252328006459643 miRanda -0.121256711789669 2.5284767348966e-05 NA NA NA hsa-miR-106b-5p CHP2 1.47447672652218 1.32004094930462e-13 -0.698246795377642 0.27546655425478 MirTarget -0.289307563984085 0.046059718658527 NA NA NA hsa-miR-582-5p CHP2 1.08286181406653 0.00149040450161757 -0.698246795377642 0.27546655425478 miRNATAP -0.174545230260245 0.0486087191670937 NA NA NA hsa-miR-26b-5p CREBBP 0.72362441215247 4.7794659748036e-05 -0.117888962254313 0.332704389567094 miRNATAP -0.107061826766823 0.00062047995861088 NA NA NA hsa-miR-590-3p CREBBP 0.83851360565783 0.00129224433453587 -0.117888962254313 0.332704389567094 PITA;miRanda;mirMAP;miRNATAP -0.141497558961106 2.26793984615809e-08 NA NA NA hsa-miR-186-5p CSNK1A1 0.852175445703945 6.88885738584309e-10 0.0966954351176312 0.354046679595029 miRNAWalker2_validate;miRNATAP -0.103455885230007 0.00262909567122314 NA NA NA hsa-miR-576-5p CSNK1A1 1.02693643167056 1.14846964470173e-06 0.0966954351176312 0.354046679595029 mirMAP -0.117350057473981 1.28052416619253e-07 NA NA NA hsa-miR-30a-3p CSNK1E -2.54042202792785 2.9111625410859e-18 0.278381360256052 0.0363387376050516 miRNATAP -0.101232623060726 4.11541018280741e-07 NA NA NA hsa-miR-125a-5p CSNK2A1 -1.04824536696301 3.97386082850476e-07 0.422788469903178 0.000505331179706292 MirTarget;PITA;miRanda -0.135860875013588 3.41368106598432e-07 NA NA NA hsa-miR-146b-5p CSNK2A1 1.0922867893808 5.63754607494775e-06 0.422788469903178 0.000505331179706292 miRanda -0.14964531833654 4.29705541584207e-11 NA NA NA hsa-miR-362-3p CSNK2A1 0.194097672030785 0.52808475179225 0.422788469903178 0.000505331179706292 miRanda;miRNATAP -0.10052396748648 9.34639988809708e-06 NA NA NA hsa-miR-186-5p CSNK2A2 0.852175445703945 6.88885738584309e-10 -0.191143312307237 0.0642504209246657 mirMAP -0.141401229692606 3.1005720168366e-05 NA NA NA hsa-miR-342-3p CTBP2 -0.128691966564961 0.561034080130801 0.395304525688879 0.000338165082027985 MirTarget;PITA;miRanda;miRNATAP -0.162664857415699 5.24584435415366e-13 NA NA NA hsa-miR-532-3p CTNNB1 -0.677758187385834 0.0147557885796065 -0.0107290862071228 0.94149303042168 miRNAWalker2_validate -0.10624268556781 9.19755717985264e-06 NA NA NA hsa-miR-421 CTNNBIP1 0.170525317701774 0.535277026680289 -0.641585550939618 5.33181666741139e-05 miRanda;mirMAP -0.137858062597277 1.80980018764289e-06 NA NA NA hsa-miR-130a-3p CXXC4 0.881660100597014 0.000158893668519248 0.0566167029048437 0.898573597373873 miRNATAP -0.246236651361005 0.00475991187141915 NA NA NA hsa-miR-140-5p CXXC4 0.669142684153918 0.000335928403032308 0.0566167029048437 0.898573597373873 miRanda -0.23699955465444 0.035519231617032 NA NA NA hsa-miR-146a-5p CXXC4 0.684701497250824 0.0105316554224149 0.0566167029048437 0.898573597373873 MirTarget -0.350377108448351 6.59996056360575e-06 NA NA NA hsa-miR-146b-5p CXXC4 1.0922867893808 5.63754607494775e-06 0.0566167029048437 0.898573597373873 MirTarget;miRNATAP -0.464894280317033 2.37210568003522e-08 NA NA NA hsa-miR-21-5p CXXC4 4.38165933891779 1.52536633902505e-92 0.0566167029048437 0.898573597373873 mirMAP -0.222609684776617 0.00421427334204567 NA NA NA hsa-miR-223-3p CXXC4 -0.51475567451355 0.0609181549839239 0.0566167029048437 0.898573597373873 MirTarget -0.169541719989879 0.0229369336773297 NA NA NA hsa-miR-224-3p CXXC4 0.921090817288022 0.010010047721564 0.0566167029048437 0.898573597373873 mirMAP -0.172692107964404 0.00361996394190705 NA NA NA hsa-miR-224-5p CXXC4 1.9183903633152 3.22216766330296e-06 0.0566167029048437 0.898573597373873 MirTarget -0.195390915573877 6.24254533550801e-05 NA NA NA hsa-miR-450b-5p CXXC4 1.69248953402469 1.96052058003353e-07 0.0566167029048437 0.898573597373873 MirTarget;miRNATAP -0.230143526812173 0.000886674081729542 NA NA NA hsa-miR-452-5p CXXC4 0.637123950346362 0.0458173998136196 0.0566167029048437 0.898573597373873 miRNATAP -0.170167338151004 0.00785702730565741 NA NA NA hsa-miR-493-3p CXXC4 0.922332129618693 0.00676412545337527 0.0566167029048437 0.898573597373873 miRNATAP -0.125122311622931 0.0428073659672667 NA NA NA hsa-miR-589-5p CXXC4 0.233778899379261 0.228477190986199 0.0566167029048437 0.898573597373873 MirTarget;miRNATAP -0.254560663838753 0.016384111737639 NA NA NA hsa-miR-590-5p CXXC4 2.07441240363458 4.95240551694843e-14 0.0566167029048437 0.898573597373873 mirMAP -0.207463250607686 0.0209062660780443 NA NA NA hsa-miR-186-5p DAAM1 0.852175445703945 6.88885738584309e-10 -0.443372789601526 0.00894104001985379 MirTarget;mirMAP -0.178013177254362 0.00155844320236484 NA NA NA hsa-miR-19a-3p DAAM1 2.11776595911517 7.07663078397156e-10 -0.443372789601526 0.00894104001985379 miRNATAP -0.136771547246657 2.26664003733956e-07 NA NA NA hsa-miR-19b-3p DAAM1 2.10868505662119 5.40846613768389e-17 -0.443372789601526 0.00894104001985379 miRNATAP -0.13843795187779 1.08049500701948e-05 NA NA NA hsa-miR-21-5p DAAM1 4.38165933891779 1.52536633902505e-92 -0.443372789601526 0.00894104001985379 miRNAWalker2_validate -0.129454053636255 1.20464740084572e-05 NA NA NA hsa-miR-27a-3p DAAM1 0.433402568013802 0.00737164631768323 -0.443372789601526 0.00894104001985379 miRNATAP -0.110902300131825 0.0229126953711878 NA NA NA hsa-miR-29a-3p DAAM1 0.101650412194573 0.573201097011668 -0.443372789601526 0.00894104001985379 MirTarget;miRNATAP -0.148399800485558 0.000663602325761267 NA NA NA hsa-miR-29b-3p DAAM1 3.10527711861309 3.01242507282711e-32 -0.443372789601526 0.00894104001985379 MirTarget;miRNATAP -0.197635650909295 2.92835157971138e-13 NA NA NA hsa-miR-32-5p DAAM1 0.876853679269853 6.04859399018691e-05 -0.443372789601526 0.00894104001985379 miRNATAP -0.13202603926667 0.000626914181734615 NA NA NA hsa-miR-34a-5p DAAM1 1.40588612517769 8.60097477768592e-12 -0.443372789601526 0.00894104001985379 MirTarget;miRNATAP -0.167986294777519 5.61543699814513e-06 NA NA NA hsa-miR-454-3p DAAM1 1.49453641052169 4.46235742871434e-09 -0.443372789601526 0.00894104001985379 MirTarget;miRNATAP -0.167445040259422 3.13319881786422e-06 NA NA NA hsa-miR-576-5p DAAM1 1.02693643167056 1.14846964470173e-06 -0.443372789601526 0.00894104001985379 mirMAP -0.141950666434397 0.000106055211990343 NA NA NA hsa-miR-590-3p DAAM1 0.83851360565783 0.00129224433453587 -0.443372789601526 0.00894104001985379 MirTarget;miRanda;mirMAP -0.112786159858888 0.00166354668147797 NA NA NA hsa-miR-141-5p DAAM2 3.02575703771074 1.54385222591327e-32 -1.63575002900602 1.24411166382277e-06 mirMAP -0.195902123036508 0.000638646135818486 NA NA NA hsa-miR-182-5p DAAM2 3.21839823004635 5.13049145201115e-39 -1.63575002900602 1.24411166382277e-06 mirMAP -0.2134621459447 0.000258210088052591 NA NA NA hsa-miR-18a-5p DAAM2 1.37435209536521 9.2173853686829e-06 -1.63575002900602 1.24411166382277e-06 miRNAWalker2_validate -0.280726649865462 1.97624309445775e-07 NA NA NA hsa-miR-193a-3p DAAM2 0.549173467360291 0.0319030569365466 -1.63575002900602 1.24411166382277e-06 miRanda -0.317681153766389 1.56668678202965e-06 NA NA NA hsa-miR-421 DAAM2 0.170525317701774 0.535277026680289 -1.63575002900602 1.24411166382277e-06 PITA;miRanda -0.387712827165418 2.29641218162031e-10 NA NA NA hsa-miR-589-3p DAAM2 1.34253876396688 1.84935927493927e-05 -1.63575002900602 1.24411166382277e-06 mirMAP -0.159768694756752 0.0018360731150501 NA NA NA hsa-miR-590-3p DAAM2 0.83851360565783 0.00129224433453587 -1.63575002900602 1.24411166382277e-06 miRanda;mirMAP -0.390226552899291 4.51082807556656e-08 NA NA NA hsa-miR-9-5p DAAM2 4.99250901331516 2.59132733422801e-19 -1.63575002900602 1.24411166382277e-06 mirMAP -0.18157565420421 7.57446997110491e-12 NA NA NA hsa-miR-107 DKK1 0.658676029898313 5.11480446318819e-07 -0.0815673137799189 0.909078250428523 miRanda -0.582390412703647 0.0208905949250658 NA NA NA hsa-miR-29a-3p DKK1 0.101650412194573 0.573201097011668 -0.0815673137799189 0.909078250428523 miRNAWalker2_validate;miRTarBase -0.378546789859455 0.0397038059007469 NA NA NA hsa-miR-142-3p DKK2 3.98476449801341 1.56256182021111e-35 -2.4633236718169 1.11856969198376e-14 miRanda -0.110484093526306 0.0114595029672955 NA NA NA hsa-miR-193a-3p DKK2 0.549173467360291 0.0319030569365466 -2.4633236718169 1.11856969198376e-14 miRanda -0.148132833584836 0.0212858326289384 NA NA NA hsa-miR-324-5p DKK2 1.06955541886548 5.39722006604758e-05 -2.4633236718169 1.11856969198376e-14 miRanda -0.321969995987594 9.18543779254221e-09 NA NA NA hsa-miR-361-5p DKK2 0.21454431962475 0.0800957579368424 -2.4633236718169 1.11856969198376e-14 miRanda -0.284829463811501 0.0239528138675794 NA NA NA hsa-miR-576-5p DKK2 1.02693643167056 1.14846964470173e-06 -2.4633236718169 1.11856969198376e-14 mirMAP -0.298738798616952 2.4574406886439e-05 NA NA NA hsa-miR-590-3p DKK2 0.83851360565783 0.00129224433453587 -2.4633236718169 1.11856969198376e-14 miRanda;mirMAP;miRNATAP -0.200386665702777 0.00394572317570996 NA NA NA hsa-miR-590-5p DKK2 2.07441240363458 4.95240551694843e-14 -2.4633236718169 1.11856969198376e-14 miRanda -0.428331735408766 5.06502656501701e-11 NA NA NA hsa-miR-664a-3p DKK2 0.443077463053857 0.0214248925850984 -2.4633236718169 1.11856969198376e-14 mirMAP -0.18771172943595 0.017527824971062 NA NA NA hsa-miR-10a-5p DVL1 0.790595816051606 0.000593731378445468 0.537116741650716 0.00278581195143785 miRNAWalker2_validate -0.189413502532476 9.88413912627841e-08 NA NA NA hsa-miR-378a-3p DVL1 -2.0140903990983 1.146745431034e-18 0.537116741650716 0.00278581195143785 miRNAWalker2_validate -0.149505366560106 1.73014077594512e-05 NA NA NA hsa-miR-221-3p DVL2 -0.0986794612964683 0.654454148658401 0.153977175010176 0.173455299106473 miRNAWalker2_validate -0.151498096790727 6.50854487638767e-11 21487968 MiR 221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2; We also suggest that miR-221 may control the migration of AIPC cells through DVL2 working as a key regulator in advanced CaP staging prostate cancer hsa-miR-27a-3p DVL2 0.433402568013802 0.00737164631768323 0.153977175010176 0.173455299106473 miRNATAP -0.131356980312861 4.36386056136407e-05 NA NA NA hsa-miR-27b-3p DVL2 0.236438984240408 0.12263510345883 0.153977175010176 0.173455299106473 miRNATAP -0.110422616929709 0.00124237687721228 NA NA NA hsa-let-7a-5p DVL3 -1.37014061604018 3.11451492971224e-14 0.469598709675249 5.08889848281915e-05 TargetScan -0.196140360872535 5.12757954456713e-12 NA NA NA hsa-miR-26b-5p DVL3 0.72362441215247 4.7794659748036e-05 0.469598709675249 5.08889848281915e-05 miRNAWalker2_validate -0.105711667021789 0.000428610590238721 NA NA NA hsa-miR-30a-3p DVL3 -2.54042202792785 2.9111625410859e-18 0.469598709675249 5.08889848281915e-05 MirTarget -0.112956661058372 7.70147345102754e-11 NA NA NA hsa-miR-30d-3p DVL3 0.00396376345349925 0.986457040013182 0.469598709675249 5.08889848281915e-05 MirTarget -0.102036980859097 7.20837596129398e-05 NA NA NA hsa-miR-30e-3p DVL3 -0.104420043859122 0.526240453209293 0.469598709675249 5.08889848281915e-05 MirTarget -0.133644394662235 4.34952118264702e-05 NA NA NA hsa-miR-140-5p EP300 0.669142684153918 0.000335928403032308 -0.24151027236021 0.0464135090934499 miRNAWalker2_validate -0.132228422733875 1.433084313638e-05 NA NA NA hsa-miR-142-5p EP300 1.29672439149353 4.0768822158894e-06 -0.24151027236021 0.0464135090934499 PITA;mirMAP;miRNATAP -0.121097424575162 7.94195192122639e-09 23342264 In contrast to the mouse p300 gene the human p300 gene was not found to be a target for miR-142-5p B cell lymphoma hsa-miR-26b-5p EP300 0.72362441215247 4.7794659748036e-05 -0.24151027236021 0.0464135090934499 miRNAWalker2_validate;miRNATAP -0.189576310673603 7.38860268524093e-10 NA NA NA hsa-miR-342-3p EP300 -0.128691966564961 0.561034080130801 -0.24151027236021 0.0464135090934499 MirTarget;PITA;miRanda;miRNATAP -0.163349604222849 4.45040401044694e-11 NA NA NA hsa-miR-590-3p EP300 0.83851360565783 0.00129224433453587 -0.24151027236021 0.0464135090934499 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.131033799746553 2.28041521831593e-07 NA NA NA hsa-miR-96-5p EP300 3.0381097138467 4.40362891630201e-24 -0.24151027236021 0.0464135090934499 TargetScan;miRNATAP -0.111815289027979 2.63317047880807e-08 NA NA NA hsa-miR-106b-5p FBXW11 1.47447672652218 1.32004094930462e-13 -0.304254731329676 0.0102183490252362 miRNATAP -0.126298023858063 1.9170408960343e-06 NA NA NA hsa-miR-130b-3p FBXW11 1.83046548750752 5.04753914574694e-13 -0.304254731329676 0.0102183490252362 MirTarget -0.122718315806876 1.91282443061689e-08 NA NA NA hsa-miR-148b-3p FBXW11 0.483970528590224 0.0026495409465901 -0.304254731329676 0.0102183490252362 miRNAWalker2_validate -0.103348505983789 0.00237906115080139 NA NA NA hsa-miR-17-5p FBXW11 2.07078488653279 2.77403038572568e-19 -0.304254731329676 0.0102183490252362 TargetScan;miRNATAP -0.167027938373327 4.52313762859858e-14 NA NA NA hsa-miR-186-5p FBXW11 0.852175445703945 6.88885738584309e-10 -0.304254731329676 0.0102183490252362 mirMAP -0.175750885983245 6.55467779816094e-06 NA NA NA hsa-miR-19a-3p FBXW11 2.11776595911517 7.07663078397156e-10 -0.304254731329676 0.0102183490252362 MirTarget -0.143452154166452 1.98044424581938e-15 NA NA NA hsa-miR-19b-3p FBXW11 2.10868505662119 5.40846613768389e-17 -0.304254731329676 0.0102183490252362 MirTarget -0.119924843906287 3.73194704106557e-08 NA NA NA hsa-miR-20a-5p FBXW11 2.64649625616975 5.1469418982085e-27 -0.304254731329676 0.0102183490252362 miRNATAP -0.143416317717865 2.39931189775028e-12 NA NA NA hsa-miR-454-3p FBXW11 1.49453641052169 4.46235742871434e-09 -0.304254731329676 0.0102183490252362 MirTarget -0.169952238371185 5.80951107599515e-12 NA NA NA hsa-miR-590-3p FBXW11 0.83851360565783 0.00129224433453587 -0.304254731329676 0.0102183490252362 mirMAP -0.149942542187609 1.14712601574015e-09 NA NA NA hsa-miR-93-5p FBXW11 1.50844106515467 1.83836866996875e-12 -0.304254731329676 0.0102183490252362 miRNATAP -0.176311222713498 4.21086569405097e-13 NA NA NA hsa-miR-942-5p FBXW11 -0.0372813055050076 0.870631058767894 -0.304254731329676 0.0102183490252362 MirTarget -0.158672486621794 4.2670769473323e-11 NA NA NA hsa-miR-96-5p FBXW11 3.0381097138467 4.40362891630201e-24 -0.304254731329676 0.0102183490252362 MirTarget;TargetScan;miRNATAP -0.106705593230835 5.80920933501703e-08 NA NA NA hsa-miR-326 FOSL1 -0.992397386750901 0.00335173765975096 -0.165525066118656 0.701922388976116 miRanda -0.291348800212481 5.20731560118242e-07 NA NA NA hsa-miR-330-5p FOSL1 0.168520831101569 0.336433937906706 -0.165525066118656 0.701922388976116 miRanda -0.26421740175311 0.0211964232572022 NA NA NA hsa-miR-429 FOSL1 2.3794516574089 1.72813419703734e-13 -0.165525066118656 0.701922388976116 miRanda;miRNATAP -0.302054339689753 2.8810504206678e-06 NA NA NA hsa-miR-454-3p FOSL1 1.49453641052169 4.46235742871434e-09 -0.165525066118656 0.701922388976116 MirTarget -0.181392742977264 0.0494423896999152 NA NA NA hsa-miR-222-3p FRAT2 0.0327210697409583 0.881937768109611 0.110290777391879 0.501834492901992 miRNATAP -0.255148885576675 2.58095746291772e-14 NA NA NA hsa-miR-148b-5p FZD1 1.39335695292409 2.13220380550073e-07 -0.364780801849827 0.099789866871212 MirTarget -0.238991392112307 8.35167122011463e-08 NA NA NA hsa-miR-186-5p FZD1 0.852175445703945 6.88885738584309e-10 -0.364780801849827 0.099789866871212 mirMAP -0.332559523219329 5.26187654799382e-06 NA NA NA hsa-miR-192-5p FZD1 2.03412119423736 1.6357945826287e-05 -0.364780801849827 0.099789866871212 miRNAWalker2_validate -0.134725053543569 1.43082682392726e-10 NA NA NA hsa-miR-215-5p FZD1 0.116505586532384 0.8384722675454 -0.364780801849827 0.099789866871212 miRNAWalker2_validate -0.126505888779909 4.3842973814988e-10 NA NA NA hsa-miR-29b-3p FZD1 3.10527711861309 3.01242507282711e-32 -0.364780801849827 0.099789866871212 mirMAP -0.125446746266628 0.000515999817396821 NA NA NA hsa-miR-590-3p FZD1 0.83851360565783 0.00129224433453587 -0.364780801849827 0.099789866871212 miRanda -0.281562569488381 1.0442149250625e-09 NA NA NA hsa-miR-15a-5p FZD10 1.62575353599172 1.55312121019827e-19 -0.800967933189888 0.147514926192675 miRNATAP -0.343502762001818 0.0121179296311688 NA NA NA hsa-let-7b-3p FZD3 -1.81889978084306 6.9913416210266e-19 0.792931453624831 0.000876919876092158 MirTarget;miRNATAP -0.184263488630064 0.000370143171579705 NA NA NA hsa-let-7i-5p FZD3 0.605080599172936 1.48406814653206e-06 0.792931453624831 0.000876919876092158 MirTarget;miRNATAP -0.179778623358443 0.0422542571350521 NA NA NA hsa-miR-139-5p FZD3 -2.26625553116965 7.22375119369519e-16 0.792931453624831 0.000876919876092158 PITA;miRanda -0.182797349433905 1.21442125223431e-06 NA NA NA hsa-miR-140-5p FZD3 0.669142684153918 0.000335928403032308 0.792931453624831 0.000876919876092158 miRanda -0.130261861889003 0.0321062623355833 NA NA NA hsa-miR-145-5p FZD3 -1.34926078156437 2.63526538800669e-07 0.792931453624831 0.000876919876092158 mirMAP -0.107037921312479 0.0100780404504179 NA NA NA hsa-miR-146a-5p FZD3 0.684701497250824 0.0105316554224149 0.792931453624831 0.000876919876092158 MirTarget -0.252145897493699 1.30661327817041e-09 NA NA NA hsa-miR-146b-5p FZD3 1.0922867893808 5.63754607494775e-06 0.792931453624831 0.000876919876092158 MirTarget;miRanda -0.28376896499448 2.15744686260845e-10 NA NA NA hsa-miR-155-5p FZD3 0.813513839059142 0.000608282725633232 0.792931453624831 0.000876919876092158 mirMAP -0.25323142773147 3.14655446022872e-08 NA NA NA hsa-miR-16-1-3p FZD3 1.50034693398929 6.63958242991125e-10 0.792931453624831 0.000876919876092158 mirMAP -0.150111062531523 0.00682825760263687 NA NA NA hsa-miR-181a-5p FZD3 -0.375429731222937 0.0562142867129802 0.792931453624831 0.000876919876092158 mirMAP -0.283840803685511 3.60722875994079e-07 NA NA NA hsa-miR-181b-5p FZD3 0.668793269169928 0.000239998092406404 0.792931453624831 0.000876919876092158 mirMAP -0.204834760757476 0.000705023554890027 NA NA NA hsa-miR-195-3p FZD3 -1.33068822339418 6.65427393047357e-09 0.792931453624831 0.000876919876092158 mirMAP -0.219580538095868 3.263591395444e-06 NA NA NA hsa-miR-197-3p FZD3 -1.2979654860824 1.79649132641813e-07 0.792931453624831 0.000876919876092158 MirTarget -0.144882143155394 0.000927101347232451 NA NA NA hsa-miR-199a-5p FZD3 1.3057193856884 2.38429382751645e-08 0.792931453624831 0.000876919876092158 miRanda -0.131239488498703 0.00478414336244651 NA NA NA hsa-miR-23a-3p FZD3 0.111958289789488 0.393086414480463 0.792931453624831 0.000876919876092158 MirTarget -0.347104426876378 4.62727121014698e-05 NA NA NA hsa-miR-27a-3p FZD3 0.433402568013802 0.00737164631768323 0.792931453624831 0.000876919876092158 miRNATAP -0.206725703152599 0.00257984967214742 NA NA NA hsa-miR-28-3p FZD3 0.387144500601444 0.00777919765254534 0.792931453624831 0.000876919876092158 mirMAP -0.219519505791961 0.00413988794328123 NA NA NA hsa-miR-29a-5p FZD3 1.89519956688438 1.03453349363915e-11 0.792931453624831 0.000876919876092158 mirMAP -0.142497038330642 0.0020659140986233 NA NA NA hsa-miR-30a-3p FZD3 -2.54042202792785 2.9111625410859e-18 0.792931453624831 0.000876919876092158 mirMAP -0.168028482901559 3.29027671651236e-06 NA NA NA hsa-miR-30a-5p FZD3 -0.924084264430689 0.000762030454634728 0.792931453624831 0.000876919876092158 MirTarget;miRNATAP -0.205215429689742 2.17849168944962e-07 NA NA NA hsa-miR-30c-5p FZD3 -0.327319105755825 0.123595832152687 0.792931453624831 0.000876919876092158 MirTarget;miRNATAP -0.231892280936853 7.34583171020351e-06 NA NA NA hsa-miR-30e-3p FZD3 -0.104420043859122 0.526240453209293 0.792931453624831 0.000876919876092158 mirMAP -0.198022417413322 0.00338144912718026 NA NA NA hsa-miR-342-3p FZD3 -0.128691966564961 0.561034080130801 0.792931453624831 0.000876919876092158 miRanda -0.187582992310138 0.000167550892750097 NA NA NA hsa-miR-361-5p FZD3 0.21454431962475 0.0800957579368424 0.792931453624831 0.000876919876092158 miRanda;miRNATAP -0.342058727896923 0.000182482143740012 NA NA NA hsa-miR-374a-5p FZD3 -0.197027254874826 0.298080902192861 0.792931453624831 0.000876919876092158 mirMAP -0.156256970812173 0.0175002475972072 NA NA NA hsa-miR-452-3p FZD3 0.477736876273128 0.22218404598603 0.792931453624831 0.000876919876092158 MirTarget -0.176344829529581 5.18462285335831e-08 NA NA NA hsa-miR-452-5p FZD3 0.637123950346362 0.0458173998136196 0.792931453624831 0.000876919876092158 mirMAP -0.178690042878829 1.67111604415628e-07 NA NA NA hsa-let-7i-5p FZD4 0.605080599172936 1.48406814653206e-06 -1.78542446608909 5.91969949280441e-18 MirTarget;miRNATAP -0.182576780309454 0.0213809344127049 NA NA NA hsa-miR-106b-5p FZD4 1.47447672652218 1.32004094930462e-13 -1.78542446608909 5.91969949280441e-18 miRNATAP -0.168446192536686 0.000502251662804167 NA NA NA hsa-miR-130b-3p FZD4 1.83046548750752 5.04753914574694e-13 -1.78542446608909 5.91969949280441e-18 mirMAP -0.147162792947595 0.000235559318288284 NA NA NA hsa-miR-141-3p FZD4 3.36993755486106 5.42939251147195e-32 -1.78542446608909 5.91969949280441e-18 TargetScan -0.185058884280311 5.54410805480532e-09 NA NA NA hsa-miR-15a-5p FZD4 1.62575353599172 1.55312121019827e-19 -1.78542446608909 5.91969949280441e-18 MirTarget -0.223007699123252 2.4021699884549e-05 NA NA NA hsa-miR-16-5p FZD4 0.749619098384047 4.11649450706988e-06 -1.78542446608909 5.91969949280441e-18 MirTarget -0.144766448178282 0.0172105177944577 NA NA NA hsa-miR-17-3p FZD4 1.36706429551147 4.60388403547821e-13 -1.78542446608909 5.91969949280441e-18 MirTarget -0.104260680511523 0.0423793246861717 NA NA NA hsa-miR-17-5p FZD4 2.07078488653279 2.77403038572568e-19 -1.78542446608909 5.91969949280441e-18 TargetScan -0.129489421531414 0.00166997430902038 NA NA NA hsa-miR-185-5p FZD4 1.14291034858482 2.95777119743491e-13 -1.78542446608909 5.91969949280441e-18 MirTarget -0.193616027867278 0.00179184266973846 NA NA NA hsa-miR-200c-3p FZD4 0.380533388300368 0.0842181838538353 -1.78542446608909 5.91969949280441e-18 mirMAP -0.124610785675869 0.00562310667443679 NA NA NA hsa-miR-20a-5p FZD4 2.64649625616975 5.1469418982085e-27 -1.78542446608909 5.91969949280441e-18 miRNATAP -0.129564434466346 0.000625869837775908 NA NA NA hsa-miR-21-5p FZD4 4.38165933891779 1.52536633902505e-92 -1.78542446608909 5.91969949280441e-18 mirMAP -0.290057279466341 2.0794512089728e-15 NA NA NA hsa-miR-22-5p FZD4 1.71436244278242 9.85038001236064e-15 -1.78542446608909 5.91969949280441e-18 mirMAP -0.118299378985615 0.00647964972242759 NA NA NA hsa-miR-301a-3p FZD4 2.70198002906399 1.56420889710984e-14 -1.78542446608909 5.91969949280441e-18 mirMAP -0.119699842207105 0.000390249364993268 NA NA NA hsa-miR-3127-5p FZD4 0.382717393698386 0.11535780874721 -1.78542446608909 5.91969949280441e-18 MirTarget -0.136235829435325 0.00081187616650683 NA NA NA hsa-miR-361-5p FZD4 0.21454431962475 0.0800957579368424 -1.78542446608909 5.91969949280441e-18 mirMAP -0.188374462333648 0.0221964935777489 NA NA NA hsa-miR-424-5p FZD4 1.26485330287919 6.1498991028257e-06 -1.78542446608909 5.91969949280441e-18 MirTarget -0.108389004937805 0.00194952577602808 NA NA NA hsa-miR-429 FZD4 2.3794516574089 1.72813419703734e-13 -1.78542446608909 5.91969949280441e-18 mirMAP -0.14020480629482 1.26422902483956e-05 NA NA NA hsa-miR-452-5p FZD4 0.637123950346362 0.0458173998136196 -1.78542446608909 5.91969949280441e-18 miRNATAP -0.102142755118398 0.000946827382301665 NA NA NA hsa-miR-542-3p FZD4 1.62226640768239 2.6427102465476e-10 -1.78542446608909 5.91969949280441e-18 mirMAP;miRNATAP -0.173071737031192 3.99942378374425e-06 NA NA NA hsa-miR-590-3p FZD4 0.83851360565783 0.00129224433453587 -1.78542446608909 5.91969949280441e-18 miRanda;mirMAP;miRNATAP -0.125164665887518 0.00584820326674969 NA NA NA hsa-miR-590-5p FZD4 2.07441240363458 4.95240551694843e-14 -1.78542446608909 5.91969949280441e-18 mirMAP -0.184657349030045 1.86727859822008e-05 NA NA NA hsa-miR-7-1-3p FZD4 2.61364240402652 1.98959237815786e-32 -1.78542446608909 5.91969949280441e-18 mirMAP -0.185757427372638 2.33266926699486e-05 NA NA NA hsa-miR-708-5p FZD4 3.04047795672813 3.01085192850869e-20 -1.78542446608909 5.91969949280441e-18 miRNATAP -0.109647717679213 0.000615279688227838 NA NA NA hsa-miR-98-5p FZD4 1.170602085804 1.09900501665229e-08 -1.78542446608909 5.91969949280441e-18 MirTarget -0.19236058291101 7.98426929301211e-05 NA NA NA hsa-let-7a-3p FZD5 0.167285443861993 0.431834813181487 -0.705926982163628 0.000105007898539503 miRNATAP -0.115040442140511 0.00992055050107584 NA NA NA hsa-miR-100-5p FZD5 0.423440403609931 0.104072937074013 -0.705926982163628 0.000105007898539503 MirTarget;miRNATAP -0.103599747968345 0.00136344793062504 NA NA NA hsa-miR-142-5p FZD5 1.29672439149353 4.0768822158894e-06 -0.705926982163628 0.000105007898539503 mirMAP -0.202548530400874 1.53436002794766e-10 NA NA NA hsa-miR-155-5p FZD5 0.813513839059142 0.000608282725633232 -0.705926982163628 0.000105007898539503 miRNATAP -0.268794133777123 5.99765164934705e-15 NA NA NA hsa-miR-186-5p FZD5 0.852175445703945 6.88885738584309e-10 -0.705926982163628 0.000105007898539503 mirMAP -0.128732270055807 0.0343773221454371 NA NA NA hsa-miR-191-5p FZD5 0.343645878547116 0.0668114086143391 -0.705926982163628 0.000105007898539503 miRNATAP -0.120521800227365 0.00771147788637244 NA NA NA hsa-miR-22-5p FZD5 1.71436244278242 9.85038001236064e-15 -0.705926982163628 0.000105007898539503 mirMAP -0.188436559704749 2.77750440904441e-07 NA NA NA hsa-miR-23a-3p FZD5 0.111958289789488 0.393086414480463 -0.705926982163628 0.000105007898539503 miRNATAP -0.254562167715161 9.45722420510268e-05 NA NA NA hsa-miR-342-3p FZD5 -0.128691966564961 0.561034080130801 -0.705926982163628 0.000105007898539503 PITA -0.23768020919403 2.58235345026286e-10 NA NA NA hsa-miR-409-3p FZD5 0.476201525793412 0.182989887810807 -0.705926982163628 0.000105007898539503 mirMAP -0.120279985399845 2.48814905463711e-07 NA NA NA hsa-miR-450b-5p FZD5 1.69248953402469 1.96052058003353e-07 -0.705926982163628 0.000105007898539503 mirMAP -0.152206586253227 7.34002441589538e-08 NA NA NA hsa-miR-493-5p FZD5 0.491314139739658 0.134743813669005 -0.705926982163628 0.000105007898539503 mirMAP -0.128674633229396 4.07693171229115e-07 NA NA NA hsa-miR-590-3p FZD5 0.83851360565783 0.00129224433453587 -0.705926982163628 0.000105007898539503 miRanda -0.145384661603229 0.000164475405289106 NA NA NA hsa-miR-19b-3p FZD6 2.10868505662119 5.40846613768389e-17 -0.48976932567242 0.00666897711463193 MirTarget -0.109318379651282 0.001165413337554 NA NA NA hsa-miR-342-3p FZD6 -0.128691966564961 0.561034080130801 -0.48976932567242 0.00666897711463193 miRanda -0.106705130249982 0.00473208370808566 NA NA NA hsa-miR-106b-5p FZD7 1.47447672652218 1.32004094930462e-13 -0.805873120798978 0.000200127022595004 miRNATAP -0.146269360972519 0.00296533184264331 NA NA NA hsa-miR-130b-5p FZD7 1.53645187062942 1.10498816261505e-08 -0.805873120798978 0.000200127022595004 mirMAP -0.16451251495499 6.6387497439697e-06 NA NA NA hsa-miR-142-3p FZD7 3.98476449801341 1.56256182021111e-35 -0.805873120798978 0.000200127022595004 miRanda -0.101123750615978 0.000461409281641207 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p cervical and endocervical cancer hsa-miR-186-5p FZD7 0.852175445703945 6.88885738584309e-10 -0.805873120798978 0.000200127022595004 mirMAP -0.229921225466784 0.00145584804153626 NA NA NA hsa-miR-20a-5p FZD7 2.64649625616975 5.1469418982085e-27 -0.805873120798978 0.000200127022595004 miRNATAP -0.112486804586343 0.00349764834916661 NA NA NA hsa-miR-2355-5p FZD7 1.86174980095465 3.47492783095613e-13 -0.805873120798978 0.000200127022595004 MirTarget -0.130245339966042 0.00167912388768476 NA NA NA hsa-miR-335-3p FZD7 1.51116383169018 6.88553098788624e-13 -0.805873120798978 0.000200127022595004 mirMAP -0.174687541232076 0.000171920205098716 NA NA NA hsa-miR-532-5p FZD7 0.576620898517708 0.0023245812680956 -0.805873120798978 0.000200127022595004 PITA;miRNATAP -0.120726838151912 0.0232466727152554 NA NA NA hsa-miR-590-3p FZD7 0.83851360565783 0.00129224433453587 -0.805873120798978 0.000200127022595004 miRanda -0.151266288868364 0.00101249610871224 NA NA NA hsa-miR-100-5p FZD8 0.423440403609931 0.104072937074013 -0.671875080608357 0.00760811728424741 MirTarget -0.15045328970468 0.000737292478688576 NA NA NA hsa-miR-590-3p FZD8 0.83851360565783 0.00129224433453587 -0.671875080608357 0.00760811728424741 miRanda -0.118955268702082 0.0260589049484398 NA NA NA hsa-miR-7-1-3p FZD8 2.61364240402652 1.98959237815786e-32 -0.671875080608357 0.00760811728424741 MirTarget -0.109355741880558 0.0354167704694647 NA NA NA hsa-miR-192-5p FZD9 2.03412119423736 1.6357945826287e-05 0.900936731866829 0.109819964845664 miRNATAP -0.257658573611763 1.82050748836927e-06 NA NA NA hsa-miR-146b-5p GSK3B 1.0922867893808 5.63754607494775e-06 -0.319504109269896 0.00509554373726706 miRanda -0.120312213108812 1.7975506993317e-08 NA NA NA hsa-miR-181a-5p GSK3B -0.375429731222937 0.0562142867129802 -0.319504109269896 0.00509554373726706 mirMAP -0.132846513131072 5.69040547461192e-07 NA NA NA hsa-miR-181b-5p GSK3B 0.668793269169928 0.000239998092406404 -0.319504109269896 0.00509554373726706 mirMAP -0.140685251831582 8.58107584485064e-07 NA NA NA hsa-miR-199a-5p GSK3B 1.3057193856884 2.38429382751645e-08 -0.319504109269896 0.00509554373726706 PITA;miRanda;miRNATAP -0.121841478766833 2.53412001096022e-08 NA NA NA hsa-miR-199b-5p GSK3B 2.13822205171062 4.56262988762436e-15 -0.319504109269896 0.00509554373726706 PITA;miRanda;miRNATAP -0.100321514688164 5.34622168763933e-08 NA NA NA hsa-miR-26b-5p GSK3B 0.72362441215247 4.7794659748036e-05 -0.319504109269896 0.00509554373726706 miRNATAP -0.157953924331919 5.91797033962096e-08 NA NA NA hsa-miR-29a-3p GSK3B 0.101650412194573 0.573201097011668 -0.319504109269896 0.00509554373726706 miRNATAP -0.116338386401065 6.72434775060363e-05 NA NA NA hsa-miR-29b-3p GSK3B 3.10527711861309 3.01242507282711e-32 -0.319504109269896 0.00509554373726706 miRTarBase;miRNATAP -0.120996712920378 3.47881082150066e-11 NA NA NA hsa-miR-342-3p GSK3B -0.128691966564961 0.561034080130801 -0.319504109269896 0.00509554373726706 miRanda -0.118246314250764 5.34302901573344e-07 NA NA NA hsa-miR-664a-3p GSK3B 0.443077463053857 0.0214248925850984 -0.319504109269896 0.00509554373726706 mirMAP -0.143789851437302 1.0690658876804e-07 NA NA NA hsa-miR-141-3p JUN 3.36993755486106 5.42939251147195e-32 -0.999359590084937 1.13112331580714e-06 miRNATAP -0.117569383056825 0.000149604234896854 NA NA NA hsa-miR-148a-5p JUN 1.45633512586855 1.81792463521257e-08 -0.999359590084937 1.13112331580714e-06 miRNATAP -0.104130733311401 0.00423603987630484 NA NA NA hsa-miR-200c-3p JUN 0.380533388300368 0.0842181838538353 -0.999359590084937 1.13112331580714e-06 MirTarget -0.111918164578752 0.0101351366823974 NA NA NA hsa-miR-107 LEF1 0.658676029898313 5.11480446318819e-07 0.588024418569192 0.00773878613348744 miRanda -0.262842866172606 0.000738685814950871 NA NA NA hsa-miR-26b-5p LEF1 0.72362441215247 4.7794659748036e-05 0.588024418569192 0.00773878613348744 miRNATAP -0.139368195747163 0.0149967116356259 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression colon cancer hsa-miR-3065-3p LEF1 0.381740717819351 0.30795546546997 0.588024418569192 0.00773878613348744 miRNATAP -0.11840997118237 1.18212026315203e-05 NA NA NA hsa-miR-3065-5p LEF1 0.653308707552535 0.0999497219778851 0.588024418569192 0.00773878613348744 miRNATAP -0.130781255877128 2.27551750259261e-06 NA NA NA hsa-miR-335-3p LEF1 1.51116383169018 6.88553098788624e-13 0.588024418569192 0.00773878613348744 mirMAP -0.105266359692155 0.026487337390556 NA NA NA hsa-miR-15a-5p LRP6 1.62575353599172 1.55312121019827e-19 -0.330500567304233 0.0478105745633487 miRNATAP -0.110166820753875 0.007614432890487 NA NA NA hsa-miR-16-5p LRP6 0.749619098384047 4.11649450706988e-06 -0.330500567304233 0.0478105745633487 miRNATAP -0.128840552259652 0.00633835808300635 NA NA NA hsa-miR-193a-3p LRP6 0.549173467360291 0.0319030569365466 -0.330500567304233 0.0478105745633487 miRanda -0.165172391469128 3.14064330608101e-07 NA NA NA hsa-miR-221-3p LRP6 -0.0986794612964683 0.654454148658401 -0.330500567304233 0.0478105745633487 miRNAWalker2_validate -0.112677510453746 0.00127320955265033 NA NA NA hsa-miR-424-5p LRP6 1.26485330287919 6.1498991028257e-06 -0.330500567304233 0.0478105745633487 miRNATAP -0.150168490214087 2.34298176795828e-08 NA NA NA hsa-miR-450b-5p LRP6 1.69248953402469 1.96052058003353e-07 -0.330500567304233 0.0478105745633487 PITA;mirMAP;miRNATAP -0.135428598467453 1.53267522186453e-07 NA NA NA hsa-miR-505-3p LRP6 0.239188197517314 0.273992679374017 -0.330500567304233 0.0478105745633487 mirMAP -0.101313558630688 0.00409157500196212 NA NA NA hsa-miR-590-3p LRP6 0.83851360565783 0.00129224433453587 -0.330500567304233 0.0478105745633487 PITA;miRanda;miRNATAP -0.21468576232976 6.37798792623999e-10 NA NA NA hsa-miR-590-5p LRP6 2.07441240363458 4.95240551694843e-14 -0.330500567304233 0.0478105745633487 PITA;miRanda;miRNATAP -0.162768972090662 1.13320150296887e-06 NA NA NA hsa-miR-671-5p LRP6 2.24156654191798 2.10433241567652e-14 -0.330500567304233 0.0478105745633487 PITA -0.130584474469196 1.61653256577978e-05 NA NA NA hsa-miR-181a-5p MAP3K7 -0.375429731222937 0.0562142867129802 0.116252164339675 0.274405047174939 MirTarget -0.111698155657412 6.22522745685755e-06 NA NA NA hsa-miR-181c-5p MAP3K7 0.529875814537156 0.0125885822998008 0.116252164339675 0.274405047174939 MirTarget -0.129190904013072 1.22677438228686e-08 NA NA NA hsa-miR-200a-3p MAP3K7 3.14766878548496 1.32850889777422e-21 0.116252164339675 0.274405047174939 miRNATAP -0.102466967282915 3.97764933743127e-13 NA NA NA hsa-miR-30d-3p MAP3K7 0.00396376345349925 0.986457040013182 0.116252164339675 0.274405047174939 MirTarget -0.118805888412381 3.21288737812328e-07 NA NA NA hsa-miR-34a-5p MAP3K7 1.40588612517769 8.60097477768592e-12 0.116252164339675 0.274405047174939 miRNAWalker2_validate -0.120284247295212 1.63104067360889e-07 NA NA NA hsa-miR-664a-3p MAP3K7 0.443077463053857 0.0214248925850984 0.116252164339675 0.274405047174939 MirTarget;mirMAP -0.176609609279063 1.12063711674263e-12 NA NA NA hsa-miR-130b-3p MAPK10 1.83046548750752 5.04753914574694e-13 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.537034366335229 2.86966630336949e-16 NA NA NA hsa-miR-193a-3p MAPK10 0.549173467360291 0.0319030569365466 -1.84555409354538 2.44653235090281e-07 miRanda;miRNATAP -0.208049144667707 0.0032825904748623 NA NA NA hsa-miR-19a-3p MAPK10 2.11776595911517 7.07663078397156e-10 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.265750080258195 2.59683060133796e-06 NA NA NA hsa-miR-19b-3p MAPK10 2.10868505662119 5.40846613768389e-17 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.189921398261328 0.00493497607488942 NA NA NA hsa-miR-29b-3p MAPK10 3.10527711861309 3.01242507282711e-32 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.171823093280894 0.0036980764764073 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 2.70198002906399 1.56420889710984e-14 -1.84555409354538 2.44653235090281e-07 miRNATAP -0.174017260988062 0.00229185658757323 NA NA NA hsa-miR-450b-5p MAPK10 1.69248953402469 1.96052058003353e-07 -1.84555409354538 2.44653235090281e-07 mirMAP -0.186795960249825 0.000949224747958845 NA NA NA hsa-miR-582-5p MAPK10 1.08286181406653 0.00149040450161757 -1.84555409354538 2.44653235090281e-07 PITA -0.23826284159421 1.53674093759886e-06 NA NA NA hsa-miR-590-3p MAPK10 0.83851360565783 0.00129224433453587 -1.84555409354538 2.44653235090281e-07 miRanda;mirMAP -0.487483452887983 9.33422066806689e-11 NA NA NA hsa-miR-590-5p MAPK10 2.07441240363458 4.95240551694843e-14 -1.84555409354538 2.44653235090281e-07 PITA;miRanda;miRNATAP -0.563200566282606 2.40959066969729e-15 NA NA NA hsa-miR-940 MAPK10 0.011138136211269 0.974925352379525 -1.84555409354538 2.44653235090281e-07 PITA;miRNATAP -0.159477320006351 0.00256734578442865 NA NA NA hsa-let-7a-3p MAPK8 0.167285443861993 0.431834813181487 0.0632162214250305 0.668341664440464 mirMAP -0.157930246462243 9.14454944313728e-06 NA NA NA hsa-miR-125a-5p MAPK8 -1.04824536696301 3.97386082850476e-07 0.0632162214250305 0.668341664440464 miRNAWalker2_validate -0.15184015518388 2.49402331215943e-06 NA NA NA hsa-miR-140-3p MAPK8 -1.11373309124537 8.35257079443689e-14 0.0632162214250305 0.668341664440464 miRNAWalker2_validate -0.229670226577472 2.02179196215716e-07 NA NA NA hsa-miR-195-3p MAPK8 -1.33068822339418 6.65427393047357e-09 0.0632162214250305 0.668341664440464 mirMAP -0.164652345751543 1.11399258189077e-08 NA NA NA hsa-miR-214-3p MAPK8 -1.1136198715556 3.52054933799089e-05 0.0632162214250305 0.668341664440464 miRNAWalker2_validate -0.129072885991343 1.85416115952081e-07 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-22-5p MAPK8 1.71436244278242 9.85038001236064e-15 0.0632162214250305 0.668341664440464 mirMAP -0.167203909807138 1.25459746890825e-08 NA NA NA hsa-miR-29a-5p MAPK8 1.89519956688438 1.03453349363915e-11 0.0632162214250305 0.668341664440464 mirMAP -0.109660256227403 0.000108946728883364 NA NA NA hsa-miR-30a-5p MAPK8 -0.924084264430689 0.000762030454634728 0.0632162214250305 0.668341664440464 mirMAP -0.132224175920583 5.22028416854406e-08 NA NA NA hsa-miR-30b-5p MAPK8 0.358144314839612 0.138026229059594 0.0632162214250305 0.668341664440464 mirMAP -0.189225193682518 6.26006883961534e-12 NA NA NA hsa-miR-30c-5p MAPK8 -0.327319105755825 0.123595832152687 0.0632162214250305 0.668341664440464 mirMAP -0.293359915087209 9.16213981476922e-22 NA NA NA hsa-miR-30e-5p MAPK8 1.60414100786743 3.78951090573667e-19 0.0632162214250305 0.668341664440464 mirMAP -0.114539805431751 0.00167549358780215 NA NA NA hsa-miR-590-5p MAPK9 2.07441240363458 4.95240551694843e-14 -0.0267974823319514 0.832365388512273 miRanda -0.113762314687669 6.92148479015732e-06 NA NA NA hsa-miR-93-5p MAPK9 1.50844106515467 1.83836866996875e-12 -0.0267974823319514 0.832365388512273 miRNAWalker2_validate;miRNATAP -0.122466377512421 3.34521997692581e-06 NA NA NA hsa-miR-129-5p MMP7 -0.405735314747643 0.341485636033577 0.944562872842405 0.0772865625159451 miRanda -0.129918497608154 0.0254207494464336 NA NA NA hsa-miR-34a-5p MYC 1.40588612517769 8.60097477768592e-12 -0.594211476201249 0.0196490384548933 miRNAWalker2_validate;miRTarBase -0.160523406918217 0.0041257772904121 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 2.3794516574089 1.72813419703734e-13 -0.594211476201249 0.0196490384548933 miRNAWalker2_validate -0.178099724014789 2.94573429210347e-06 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-130b-5p NFAT5 1.53645187062942 1.10498816261505e-08 -0.409853693095821 0.00241772915052018 MirTarget;miRNATAP -0.108561642446117 1.60834322577139e-06 NA NA NA hsa-miR-132-3p NFAT5 0.0122601212105202 0.934032846062939 -0.409853693095821 0.00241772915052018 miRNATAP -0.12963519248744 0.00233856127647591 NA NA NA hsa-miR-148b-3p NFAT5 0.483970528590224 0.0026495409465901 -0.409853693095821 0.00241772915052018 miRNATAP -0.112577222828241 0.0038126543774256 NA NA NA hsa-miR-27b-5p NFAT5 1.03511957999268 7.86187917705303e-11 -0.409853693095821 0.00241772915052018 miRNATAP -0.16192960419066 2.57829034468637e-05 NA NA NA hsa-miR-590-3p NFAT5 0.83851360565783 0.00129224433453587 -0.409853693095821 0.00241772915052018 MirTarget;miRanda;mirMAP;miRNATAP -0.115936168805103 4.65917004279092e-05 NA NA NA hsa-miR-590-5p NFAT5 2.07441240363458 4.95240551694843e-14 -0.409853693095821 0.00241772915052018 PITA;mirMAP;miRNATAP -0.125507198595402 3.73504850114134e-06 NA NA NA hsa-miR-93-5p NFAT5 1.50844106515467 1.83836866996875e-12 -0.409853693095821 0.00241772915052018 MirTarget;miRNATAP -0.118263351694996 2.99203468201362e-05 NA NA NA hsa-miR-3127-5p NFATC1 0.382717393698386 0.11535780874721 -1.1375752288108 4.2403023117592e-09 MirTarget -0.111363856377225 0.00286268272528884 NA NA NA hsa-miR-421 NFATC1 0.170525317701774 0.535277026680289 -1.1375752288108 4.2403023117592e-09 miRanda -0.27250878649941 5.59172029209645e-15 NA NA NA hsa-miR-130b-5p NFATC2 1.53645187062942 1.10498816261505e-08 -1.17929519652878 0.000402858371584528 MirTarget -0.172861973245698 0.00221822037960357 NA NA NA hsa-miR-16-2-3p NFATC2 0.503964803530872 0.0263648405197492 -1.17929519652878 0.000402858371584528 mirMAP -0.178407692112819 0.0160148740478749 NA NA NA hsa-miR-182-5p NFATC2 3.21839823004635 5.13049145201115e-39 -1.17929519652878 0.000402858371584528 mirMAP -0.180422957533554 0.00169761028088969 NA NA NA hsa-miR-185-5p NFATC2 1.14291034858482 2.95777119743491e-13 -1.17929519652878 0.000402858371584528 MirTarget -0.360674698099435 0.00018867412489729 NA NA NA hsa-miR-186-5p NFATC2 0.852175445703945 6.88885738584309e-10 -1.17929519652878 0.000402858371584528 mirMAP -0.343079979359603 0.00202223937894896 NA NA NA hsa-miR-193b-5p NFATC2 0.179695858885499 0.55521472494233 -1.17929519652878 0.000402858371584528 MirTarget -0.117977647957471 0.0203484714641141 NA NA NA hsa-miR-19a-3p NFATC2 2.11776595911517 7.07663078397156e-10 -1.17929519652878 0.000402858371584528 mirMAP -0.336569537886002 7.83772096103092e-11 NA NA NA hsa-miR-19b-3p NFATC2 2.10868505662119 5.40846613768389e-17 -1.17929519652878 0.000402858371584528 mirMAP -0.37856857138205 7.5498987798628e-10 NA NA NA hsa-miR-2355-3p NFATC2 1.10676344164715 6.24068383465151e-06 -1.17929519652878 0.000402858371584528 mirMAP -0.219356663156956 0.000875934214021124 NA NA NA hsa-miR-2355-5p NFATC2 1.86174980095465 3.47492783095613e-13 -1.17929519652878 0.000402858371584528 MirTarget -0.126259768387679 0.048425095193218 NA NA NA hsa-miR-24-3p NFATC2 -0.0357874587555003 0.785865078836504 -1.17929519652878 0.000402858371584528 MirTarget -0.294004659472517 0.0138398550638032 NA NA NA hsa-miR-29a-5p NFATC2 1.89519956688438 1.03453349363915e-11 -1.17929519652878 0.000402858371584528 mirMAP;miRNATAP -0.177982407502831 0.00605902966456155 NA NA NA hsa-miR-30b-5p NFATC2 0.358144314839612 0.138026229059594 -1.17929519652878 0.000402858371584528 MirTarget;mirMAP -0.200783588972738 0.00170730601229697 NA NA NA hsa-miR-30e-5p NFATC2 1.60414100786743 3.78951090573667e-19 -1.17929519652878 0.000402858371584528 MirTarget -0.193712402291355 0.0200156921807788 NA NA NA hsa-miR-320b NFATC2 0.226640952564488 0.378818692487242 -1.17929519652878 0.000402858371584528 MirTarget -0.136739507087094 0.0230483252413662 NA NA NA hsa-miR-335-3p NFATC2 1.51116383169018 6.88553098788624e-13 -1.17929519652878 0.000402858371584528 mirMAP -0.153264362499494 0.0330110805376744 NA NA NA hsa-miR-3613-5p NFATC2 0.0237159233591191 0.934730899070298 -1.17929519652878 0.000402858371584528 mirMAP -0.24336416775385 0.000133096294572765 NA NA NA hsa-miR-590-3p NFATC2 0.83851360565783 0.00129224433453587 -1.17929519652878 0.000402858371584528 mirMAP -0.264991647100287 0.000176914211247844 NA NA NA hsa-miR-9-5p NFATC2 4.99250901331516 2.59132733422801e-19 -1.17929519652878 0.000402858371584528 MirTarget -0.105804655043001 6.44752588454657e-05 NA NA NA hsa-miR-15a-5p NFATC3 1.62575353599172 1.55312121019827e-19 -0.775339809160321 2.42596775036985e-09 MirTarget;miRNATAP -0.194760431797607 1.31515520866454e-09 NA NA NA hsa-miR-185-5p NFATC3 1.14291034858482 2.95777119743491e-13 -0.775339809160321 2.42596775036985e-09 MirTarget;miRNATAP -0.243443371940348 7.87569812717632e-11 NA NA NA hsa-miR-21-3p NFATC3 2.54206008030157 1.11598785398763e-30 -0.775339809160321 2.42596775036985e-09 MirTarget -0.144436369277164 1.38631470692728e-08 NA NA NA hsa-miR-29b-3p NFATC3 3.10527711861309 3.01242507282711e-32 -0.775339809160321 2.42596775036985e-09 MirTarget;miRNATAP -0.113008786184003 1.1536763111009e-07 NA NA NA hsa-miR-335-3p NFATC3 1.51116383169018 6.88553098788624e-13 -0.775339809160321 2.42596775036985e-09 mirMAP -0.104848301816004 0.000194709438293604 NA NA NA hsa-miR-589-3p NFATC3 1.34253876396688 1.84935927493927e-05 -0.775339809160321 2.42596775036985e-09 mirMAP -0.123021593670604 2.81638805309194e-10 NA NA NA hsa-miR-590-3p NFATC3 0.83851360565783 0.00129224433453587 -0.775339809160321 2.42596775036985e-09 miRanda -0.142048821132892 2.6995336752082e-07 NA NA NA hsa-miR-185-3p NFATC4 -0.377490365509078 0.093653288903368 0.936688963651323 2.59723598381625e-05 MirTarget -0.154954243253114 0.00074408877001007 NA NA NA hsa-miR-423-5p NFATC4 -1.80309342242719 1.34791344187441e-19 0.936688963651323 2.59723598381625e-05 miRNATAP -0.21075464541514 2.27046521867108e-05 NA NA NA hsa-miR-21-5p NKD1 4.38165933891779 1.52536633902505e-92 -1.734580414771 4.24665289948679e-06 mirMAP -0.393412938012472 2.27374130691586e-09 NA NA NA hsa-miR-185-3p NKD2 -0.377490365509078 0.093653288903368 -1.56364471046616 7.9279851691292e-07 miRNATAP -0.174968332894569 0.0078022130893923 NA NA NA hsa-let-7a-5p NLK -1.37014061604018 3.11451492971224e-14 0.200178958380761 0.0535794568700787 TargetScan;miRNATAP -0.103621418358745 5.33089533473749e-05 NA NA NA hsa-let-7i-5p NLK 0.605080599172936 1.48406814653206e-06 0.200178958380761 0.0535794568700787 miRNATAP -0.112522534494759 0.00313058994702316 NA NA NA hsa-miR-140-5p NLK 0.669142684153918 0.000335928403032308 0.200178958380761 0.0535794568700787 MirTarget;PITA;miRanda;miRNATAP -0.112541275204177 1.52265042518288e-05 NA NA NA hsa-miR-181a-5p NLK -0.375429731222937 0.0562142867129802 0.200178958380761 0.0535794568700787 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.107008850019333 9.28298383191624e-06 NA NA NA hsa-miR-221-3p NLK -0.0986794612964683 0.654454148658401 0.200178958380761 0.0535794568700787 MirTarget;miRNATAP -0.115643852898254 6.68410917475072e-08 NA NA NA hsa-miR-222-3p NLK 0.0327210697409583 0.881937768109611 0.200178958380761 0.0535794568700787 MirTarget;miRNATAP -0.102916697650006 1.70487392395318e-06 NA NA NA hsa-miR-23a-3p NLK 0.111958289789488 0.393086414480463 0.200178958380761 0.0535794568700787 miRNAWalker2_validate;MirTarget -0.191900459374887 1.50088805987341e-07 NA NA NA hsa-miR-23b-3p NLK -0.070273068040148 0.620585267977425 0.200178958380761 0.0535794568700787 MirTarget -0.112998955682267 0.000870007705681694 NA NA NA hsa-miR-24-3p NLK -0.0357874587555003 0.785865078836504 0.200178958380761 0.0535794568700787 miRNATAP -0.122312627889454 0.000856037623694819 NA NA NA hsa-miR-26a-5p NLK -0.126411409001078 0.440028840408711 0.200178958380761 0.0535794568700787 miRNATAP -0.110559225376151 0.000156249291102499 NA NA NA hsa-miR-27a-3p NLK 0.433402568013802 0.00737164631768323 0.200178958380761 0.0535794568700787 miRNATAP -0.141087739477666 1.54945037774992e-06 NA NA NA hsa-miR-27b-3p NLK 0.236438984240408 0.12263510345883 0.200178958380761 0.0535794568700787 miRNATAP -0.117627767819408 0.000170454257441477 NA NA NA hsa-miR-125b-5p PLCB1 -0.548859243919575 0.0107224406584463 0.158764231657558 0.604491663416039 miRNATAP -0.230419516504247 0.000435632993285047 NA NA NA hsa-miR-139-5p PLCB1 -2.26625553116965 7.22375119369519e-16 0.158764231657558 0.604491663416039 miRanda -0.177033775289831 0.000258400749505133 NA NA NA hsa-miR-140-3p PLCB1 -1.11373309124537 8.35257079443689e-14 0.158764231657558 0.604491663416039 PITA -0.394399576367962 1.98980424060224e-05 NA NA NA hsa-miR-195-3p PLCB1 -1.33068822339418 6.65427393047357e-09 0.158764231657558 0.604491663416039 mirMAP -0.185987946285829 0.00220888245605511 NA NA NA hsa-miR-3065-5p PLCB1 0.653308707552535 0.0999497219778851 0.158764231657558 0.604491663416039 mirMAP -0.183263342576221 1.6905341827428e-06 NA NA NA hsa-miR-30c-5p PLCB1 -0.327319105755825 0.123595832152687 0.158764231657558 0.604491663416039 miRNAWalker2_validate -0.296343063413656 7.53301341132755e-06 NA NA NA hsa-miR-338-5p PLCB1 -1.83316380675941 4.03269924759167e-07 0.158764231657558 0.604491663416039 PITA;mirMAP;miRNATAP -0.101622450466764 0.0082652198620433 NA NA NA hsa-miR-34a-5p PLCB1 1.40588612517769 8.60097477768592e-12 0.158764231657558 0.604491663416039 miRNATAP -0.261629486927096 9.27400864448965e-05 NA NA NA hsa-miR-34c-5p PLCB1 -1.00125440032112 0.0724432896090357 0.158764231657558 0.604491663416039 miRanda;miRNATAP -0.142558484500914 5.83164725379464e-08 NA NA NA hsa-miR-452-5p PLCB1 0.637123950346362 0.0458173998136196 0.158764231657558 0.604491663416039 mirMAP -0.120710380838479 0.00626382636930349 NA NA NA hsa-miR-125a-3p PLCB2 -1.04954492275266 2.45974219476832e-06 -0.579966330869801 0.0229620514992322 miRanda;miRNATAP -0.156645091592983 0.00278395686205273 NA NA NA hsa-miR-141-3p PLCB4 3.36993755486106 5.42939251147195e-32 -1.82668492890878 7.15026249037583e-05 TargetScan -0.160326937075304 0.0212401875660248 NA NA NA hsa-miR-183-5p PLCB4 2.39247234736657 3.92444525331999e-21 -1.82668492890878 7.15026249037583e-05 miRNATAP -0.32327679918221 5.55690039859461e-05 NA NA NA hsa-miR-450b-5p PLCB4 1.69248953402469 1.96052058003353e-07 -1.82668492890878 7.15026249037583e-05 PITA;mirMAP -0.286546165433203 7.08834098737478e-05 NA NA NA hsa-miR-454-3p PLCB4 1.49453641052169 4.46235742871434e-09 -1.82668492890878 7.15026249037583e-05 miRNATAP -0.260882827388958 0.00831158202421903 NA NA NA hsa-miR-590-3p PLCB4 0.83851360565783 0.00129224433453587 -1.82668492890878 7.15026249037583e-05 miRanda -0.349124663122461 0.000356727663520599 NA NA NA hsa-miR-708-3p PLCB4 3.43841959417743 4.40027692981683e-28 -1.82668492890878 7.15026249037583e-05 miRNATAP -0.149429610405033 0.0375109950519147 NA NA NA hsa-miR-9-5p PLCB4 4.99250901331516 2.59132733422801e-19 -1.82668492890878 7.15026249037583e-05 miRNAWalker2_validate;mirMAP -0.107737977725213 0.00338080296219067 NA NA NA hsa-miR-96-5p PLCB4 3.0381097138467 4.40362891630201e-24 -1.82668492890878 7.15026249037583e-05 TargetScan;miRNATAP -0.312602828639921 5.66117781357207e-05 NA NA NA hsa-miR-148b-3p PPARD 0.483970528590224 0.0026495409465901 0.320208379453486 0.0232853135752942 mirMAP -0.100952115479032 0.012941038688345 NA NA NA hsa-miR-125a-5p PPP2CA -1.04824536696301 3.97386082850476e-07 0.00351977565606187 0.97004225712613 miRanda -0.108592476267422 9.06041337720993e-08 NA NA NA hsa-miR-30c-5p PPP2CA -0.327319105755825 0.123595832152687 0.00351977565606187 0.97004225712613 mirMAP -0.131381693408342 3.54219270743565e-11 NA NA NA hsa-miR-664a-3p PPP2CA 0.443077463053857 0.0214248925850984 0.00351977565606187 0.97004225712613 mirMAP -0.129991418169681 3.46486829402912e-09 NA NA NA hsa-miR-183-5p PPP2CB 2.39247234736657 3.92444525331999e-21 -0.810479191024634 2.22590279447859e-10 MirTarget;miRNATAP -0.107046241719826 1.76590312582065e-06 NA NA NA hsa-miR-421 PPP2CB 0.170525317701774 0.535277026680289 -0.810479191024634 2.22590279447859e-10 miRNAWalker2_validate;miRanda -0.101748717017346 1.55432203300377e-05 NA NA NA hsa-miR-425-5p PPP2CB 1.21659524959201 8.01126418494715e-09 -0.810479191024634 2.22590279447859e-10 miRNAWalker2_validate -0.230017713976039 2.01900497107045e-17 NA NA NA hsa-miR-590-3p PPP2CB 0.83851360565783 0.00129224433453587 -0.810479191024634 2.22590279447859e-10 miRanda -0.115437970142581 2.41175906636951e-05 NA NA NA hsa-let-7b-3p PPP2R1B -1.81889978084306 6.9913416210266e-19 0.389306891256743 0.0156214207023678 mirMAP -0.12563396102696 0.000308074800959593 NA NA NA hsa-miR-125a-5p PPP2R1B -1.04824536696301 3.97386082850476e-07 0.389306891256743 0.0156214207023678 PITA;miRanda -0.195127723279487 2.8467995200931e-08 NA NA NA hsa-miR-139-5p PPP2R1B -2.26625553116965 7.22375119369519e-16 0.389306891256743 0.0156214207023678 MirTarget;miRanda -0.141997973480572 1.83424283877756e-08 NA NA NA hsa-miR-146b-5p PPP2R1B 1.0922867893808 5.63754607494775e-06 0.389306891256743 0.0156214207023678 miRanda -0.153736063085509 3.91553637047229e-07 NA NA NA hsa-miR-195-5p PPP2R1B -1.01577502605386 4.80814718341729e-05 0.389306891256743 0.0156214207023678 MirTarget -0.160400894716198 1.92075736299728e-07 NA NA NA hsa-miR-30a-3p PPP2R1B -2.54042202792785 2.9111625410859e-18 0.389306891256743 0.0156214207023678 mirMAP -0.105044026185593 1.59679854839767e-05 NA NA NA hsa-miR-30a-5p PPP2R1B -0.924084264430689 0.000762030454634728 0.389306891256743 0.0156214207023678 miRNATAP -0.144523567937466 5.55199488995584e-08 NA NA NA hsa-miR-30b-5p PPP2R1B 0.358144314839612 0.138026229059594 0.389306891256743 0.0156214207023678 miRNATAP -0.176137121142005 6.61523702854927e-09 NA NA NA hsa-miR-30c-2-3p PPP2R1B -3.10905250533941 6.84550165664783e-27 0.389306891256743 0.0156214207023678 MirTarget -0.104611308214946 1.32100635149458e-05 NA NA NA hsa-miR-30c-5p PPP2R1B -0.327319105755825 0.123595832152687 0.389306891256743 0.0156214207023678 miRNATAP -0.186116442727994 7.75959880994156e-08 NA NA NA hsa-miR-30d-3p PPP2R1B 0.00396376345349925 0.986457040013182 0.389306891256743 0.0156214207023678 mirMAP -0.162627010104191 4.61956599491588e-06 NA NA NA hsa-miR-30d-5p PPP2R1B -0.920901858717441 3.50898334321668e-05 0.389306891256743 0.0156214207023678 miRNATAP -0.166997113759972 3.71778141719134e-07 NA NA NA hsa-miR-497-5p PPP2R1B -0.0546347378264729 0.786205564901684 0.389306891256743 0.0156214207023678 MirTarget -0.240684090468845 3.54495469439715e-11 NA NA NA hsa-miR-197-3p PPP2R5A -1.2979654860824 1.79649132641813e-07 -0.737226577258355 1.38948777844013e-06 MirTarget -0.113718473107373 5.1741723703863e-05 NA NA NA hsa-miR-484 PPP2R5A -0.228576985124486 0.244112867390855 -0.737226577258355 1.38948777844013e-06 miRNAWalker2_validate -0.149079813921877 3.8434359864137e-05 NA NA NA hsa-miR-590-3p PPP2R5A 0.83851360565783 0.00129224433453587 -0.737226577258355 1.38948777844013e-06 miRNAWalker2_validate -0.134330436348155 3.47031052105344e-05 NA NA NA hsa-let-7c-5p PPP2R5E -2.14139413005852 1.66416999341685e-18 0.332284939671954 0.0100148820415654 miRNAWalker2_validate -0.101104767775318 1.43985412604838e-05 NA NA NA hsa-miR-101-5p PPP2R5E -0.0265235292039296 0.917878791358577 0.332284939671954 0.0100148820415654 MirTarget -0.175706519340553 5.76287510708925e-10 NA NA NA hsa-miR-125a-5p PPP2R5E -1.04824536696301 3.97386082850476e-07 0.332284939671954 0.0100148820415654 miRNAWalker2_validate -0.191107713661807 7.4143942159604e-12 NA NA NA hsa-miR-139-5p PPP2R5E -2.26625553116965 7.22375119369519e-16 0.332284939671954 0.0100148820415654 miRanda -0.13104117044849 6.81254893679034e-11 NA NA NA hsa-miR-181a-5p PPP2R5E -0.375429731222937 0.0562142867129802 0.332284939671954 0.0100148820415654 MirTarget;mirMAP -0.175248242128189 4.65235981309525e-09 NA NA NA hsa-miR-181c-5p PPP2R5E 0.529875814537156 0.0125885822998008 0.332284939671954 0.0100148820415654 MirTarget;mirMAP -0.148965234554764 7.52861426176726e-08 NA NA NA hsa-miR-195-3p PPP2R5E -1.33068822339418 6.65427393047357e-09 0.332284939671954 0.0100148820415654 mirMAP -0.129047075492654 3.60058877512595e-07 NA NA NA hsa-miR-29b-2-5p PPP2R5E 0.345881055247341 0.194842633194187 0.332284939671954 0.0100148820415654 mirMAP -0.173091702457262 1.22765592293387e-15 NA NA NA hsa-miR-30a-5p PPP2R5E -0.924084264430689 0.000762030454634728 0.332284939671954 0.0100148820415654 mirMAP -0.133057326058358 3.35539684717347e-10 NA NA NA hsa-miR-30b-5p PPP2R5E 0.358144314839612 0.138026229059594 0.332284939671954 0.0100148820415654 mirMAP -0.137573155177901 1.56046204052055e-08 NA NA NA hsa-miR-30c-5p PPP2R5E -0.327319105755825 0.123595832152687 0.332284939671954 0.0100148820415654 mirMAP -0.251273126950616 9.28476773142478e-21 NA NA NA hsa-miR-342-3p PPP2R5E -0.128691966564961 0.561034080130801 0.332284939671954 0.0100148820415654 miRanda -0.139443209753984 1.68863055966247e-07 NA NA NA hsa-miR-374a-5p PPP2R5E -0.197027254874826 0.298080902192861 0.332284939671954 0.0100148820415654 mirMAP -0.165778694891557 2.33707290307724e-06 NA NA NA hsa-miR-374b-5p PPP2R5E 0.474691035780475 0.0109217471394203 0.332284939671954 0.0100148820415654 mirMAP -0.120646792342735 0.000335420602376512 NA NA NA hsa-miR-455-5p PPP2R5E 1.36946341828134 5.05118627562807e-08 0.332284939671954 0.0100148820415654 miRanda -0.121105556931124 6.19726469499623e-06 NA NA NA hsa-miR-500a-3p PPP2R5E -0.137335632790721 0.545751862031252 0.332284939671954 0.0100148820415654 MirTarget -0.109857589320004 2.53627654305541e-05 NA NA NA hsa-miR-501-5p PPP2R5E 0.411357595674671 0.10435288464149 0.332284939671954 0.0100148820415654 MirTarget;PITA;mirMAP;miRNATAP -0.12370951932419 9.94452362095094e-08 NA NA NA hsa-miR-502-3p PPP2R5E -0.262270070977708 0.161760375279961 0.332284939671954 0.0100148820415654 MirTarget;PITA;miRNATAP -0.122950452888709 0.000108136086069841 NA NA NA hsa-miR-106a-5p PPP3CA 1.3902608059488 6.07931522284525e-05 -0.313973239016408 0.0165177462343014 miRNATAP -0.133933104567234 1.19345709173472e-12 NA NA NA hsa-miR-142-3p PPP3CA 3.98476449801341 1.56256182021111e-35 -0.313973239016408 0.0165177462343014 miRNATAP -0.118826172048727 2.75854825586705e-12 NA NA NA hsa-miR-17-5p PPP3CA 2.07078488653279 2.77403038572568e-19 -0.313973239016408 0.0165177462343014 miRNATAP -0.176015588845375 7.62312188608765e-13 NA NA NA hsa-miR-186-5p PPP3CA 0.852175445703945 6.88885738584309e-10 -0.313973239016408 0.0165177462343014 mirMAP -0.286847992743368 1.57472937315132e-11 NA NA NA hsa-miR-20a-5p PPP3CA 2.64649625616975 5.1469418982085e-27 -0.313973239016408 0.0165177462343014 miRNATAP -0.154552998486965 9.11892644521842e-12 NA NA NA hsa-miR-20b-5p PPP3CA 1.35770573270947 0.00260808530013016 -0.313973239016408 0.0165177462343014 miRNATAP -0.122294666346707 1.15249428256532e-19 NA NA NA hsa-miR-30c-5p PPP3CA -0.327319105755825 0.123595832152687 -0.313973239016408 0.0165177462343014 miRNATAP -0.10873673306536 0.000125286600086868 NA NA NA hsa-miR-361-3p PPP3CA 0.0988926195529967 0.549128728500555 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.173641727258806 2.07130127414673e-06 NA NA NA hsa-miR-501-3p PPP3CA -0.0405952693028064 0.866802243505833 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.152231773192009 5.82453493976863e-10 NA NA NA hsa-miR-502-3p PPP3CA -0.262270070977708 0.161760375279961 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.102225645893012 0.00155670003675052 NA NA NA hsa-miR-589-3p PPP3CA 1.34253876396688 1.84935927493927e-05 -0.313973239016408 0.0165177462343014 MirTarget -0.111512777165905 9.25189699847489e-09 NA NA NA hsa-miR-590-3p PPP3CA 0.83851360565783 0.00129224433453587 -0.313973239016408 0.0165177462343014 miRanda;mirMAP -0.108711400054004 7.97592745451833e-05 NA NA NA hsa-miR-590-5p PPP3CA 2.07441240363458 4.95240551694843e-14 -0.313973239016408 0.0165177462343014 PITA;miRanda;miRNATAP -0.177690930412641 6.75602594094779e-12 NA NA NA hsa-miR-7-1-3p PPP3CA 2.61364240402652 1.98959237815786e-32 -0.313973239016408 0.0165177462343014 MirTarget;mirMAP -0.121059394653456 5.88147588879243e-06 NA NA NA hsa-miR-93-3p PPP3CA 1.07631808403007 1.63747525692813e-05 -0.313973239016408 0.0165177462343014 miRNATAP -0.170128744194282 3.50156314525736e-13 NA NA NA hsa-miR-93-5p PPP3CA 1.50844106515467 1.83836866996875e-12 -0.313973239016408 0.0165177462343014 miRNATAP -0.25180151434334 1.28858993768457e-21 NA NA NA hsa-miR-15a-5p PPP3CB 1.62575353599172 1.55312121019827e-19 -0.217161149975175 0.026537796620393 miRNATAP -0.123109224513088 2.45320870406106e-07 NA NA NA hsa-miR-30c-5p PPP3CB -0.327319105755825 0.123595832152687 -0.217161149975175 0.026537796620393 miRNATAP -0.117562918064524 1.93721091880072e-08 NA NA NA hsa-miR-361-5p PPP3CB 0.21454431962475 0.0800957579368424 -0.217161149975175 0.026537796620393 miRanda -0.127974103120468 0.000592380004256261 NA NA NA hsa-miR-361-5p PPP3CC 0.21454431962475 0.0800957579368424 -0.864879436917075 5.11810186256782e-12 miRanda -0.162282770575647 0.000912467378574366 NA NA NA hsa-miR-181a-5p PPP3R1 -0.375429731222937 0.0562142867129802 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.174665544764319 9.40491398689482e-15 NA NA NA hsa-miR-181b-5p PPP3R1 0.668793269169928 0.000239998092406404 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.114349020464675 3.84750784901666e-06 NA NA NA hsa-miR-181c-5p PPP3R1 0.529875814537156 0.0125885822998008 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.106737924157465 4.8061231789594e-07 NA NA NA hsa-miR-27b-3p PPP3R1 0.236438984240408 0.12263510345883 -0.021451907795778 0.828812244123992 miRNATAP -0.122284709618602 4.10399666262129e-05 NA NA NA hsa-miR-30b-5p PPP3R1 0.358144314839612 0.138026229059594 -0.021451907795778 0.828812244123992 MirTarget -0.109418887183495 3.74739901258502e-09 NA NA NA hsa-miR-30c-5p PPP3R1 -0.327319105755825 0.123595832152687 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.157231202749467 5.03548982239333e-14 NA NA NA hsa-miR-342-3p PPP3R1 -0.128691966564961 0.561034080130801 -0.021451907795778 0.828812244123992 MirTarget;miRanda;miRNATAP -0.120856614371424 2.53668736670026e-09 NA NA NA hsa-miR-34a-5p PPP3R1 1.40588612517769 8.60097477768592e-12 -0.021451907795778 0.828812244123992 miRNAWalker2_validate -0.170360603226023 4.36468130338985e-16 NA NA NA hsa-miR-141-3p PRICKLE1 3.36993755486106 5.42939251147195e-32 -1.65089034062227 4.19267321353062e-10 TargetScan -0.346500597753672 5.2847980672073e-19 NA NA NA hsa-miR-17-5p PRICKLE1 2.07078488653279 2.77403038572568e-19 -1.65089034062227 4.19267321353062e-10 miRNAWalker2_validate -0.366267721871006 4.31066943515129e-13 NA NA NA hsa-miR-192-5p PRICKLE1 2.03412119423736 1.6357945826287e-05 -1.65089034062227 4.19267321353062e-10 miRNAWalker2_validate -0.13403205687806 1.91766465808908e-07 NA NA NA hsa-miR-215-5p PRICKLE1 0.116505586532384 0.8384722675454 -1.65089034062227 4.19267321353062e-10 miRNAWalker2_validate -0.101470795274127 4.76491936386059e-05 NA NA NA hsa-miR-3607-3p PRICKLE1 2.4103172144469 2.69039449048047e-08 -1.65089034062227 4.19267321353062e-10 miRNATAP -0.10363739050402 0.00022065984307471 NA NA NA hsa-miR-582-5p PRICKLE1 1.08286181406653 0.00149040450161757 -1.65089034062227 4.19267321353062e-10 miRNATAP -0.222118069114008 1.28742011609331e-09 NA NA NA hsa-miR-130b-5p PRICKLE2 1.53645187062942 1.10498816261505e-08 -1.56077600074788 2.11863685620441e-14 mirMAP -0.200769396561802 9.59343660004433e-09 NA NA NA hsa-miR-148b-3p PRICKLE2 0.483970528590224 0.0026495409465901 -1.56077600074788 2.11863685620441e-14 MirTarget;miRNATAP -0.345800929865677 6.84481017225917e-09 NA NA NA hsa-miR-15b-3p PRICKLE2 0.804736041893915 0.000400279611457186 -1.56077600074788 2.11863685620441e-14 mirMAP -0.219895542344089 7.36797336747493e-07 NA NA NA hsa-miR-16-2-3p PRICKLE2 0.503964803530872 0.0263648405197492 -1.56077600074788 2.11863685620441e-14 mirMAP -0.169389757878451 0.000250641179292821 NA NA NA hsa-miR-182-5p PRICKLE2 3.21839823004635 5.13049145201115e-39 -1.56077600074788 2.11863685620441e-14 MirTarget -0.215658489180803 1.28778857865377e-09 NA NA NA hsa-miR-186-5p PRICKLE2 0.852175445703945 6.88885738584309e-10 -1.56077600074788 2.11863685620441e-14 MirTarget -0.296272363038086 1.94719553202218e-05 NA NA NA hsa-miR-18a-5p PRICKLE2 1.37435209536521 9.2173853686829e-06 -1.56077600074788 2.11863685620441e-14 MirTarget -0.262757695682476 7.34627839189872e-16 NA NA NA hsa-miR-194-5p PRICKLE2 1.76979641760284 8.2064222072696e-05 -1.56077600074788 2.11863685620441e-14 miRNATAP -0.100005981312587 2.34509042318743e-06 NA NA NA hsa-miR-19a-3p PRICKLE2 2.11776595911517 7.07663078397156e-10 -1.56077600074788 2.11863685620441e-14 MirTarget;miRNATAP -0.1876063466371 8.7690408848808e-09 NA NA NA hsa-miR-19b-3p PRICKLE2 2.10868505662119 5.40846613768389e-17 -1.56077600074788 2.11863685620441e-14 MirTarget;miRNATAP -0.176014930881953 6.15703862298338e-06 NA NA NA hsa-miR-21-5p PRICKLE2 4.38165933891779 1.52536633902505e-92 -1.56077600074788 2.11863685620441e-14 miRNAWalker2_validate;MirTarget -0.231680719450712 1.56031172523943e-10 NA NA NA hsa-miR-212-3p PRICKLE2 0.404496907089793 0.103551762277891 -1.56077600074788 2.11863685620441e-14 MirTarget;miRNATAP -0.114984958582438 0.00319988921219438 NA NA NA hsa-miR-330-5p PRICKLE2 0.168520831101569 0.336433937906706 -1.56077600074788 2.11863685620441e-14 miRanda;miRNATAP -0.237445837374984 1.80280581063133e-05 NA NA NA hsa-miR-335-3p PRICKLE2 1.51116383169018 6.88553098788624e-13 -1.56077600074788 2.11863685620441e-14 mirMAP -0.291209700861632 4.25795826532224e-11 NA NA NA hsa-miR-33a-5p PRICKLE2 2.80127809675219 5.09053890529424e-12 -1.56077600074788 2.11863685620441e-14 MirTarget -0.14763923088043 2.37392534989391e-07 NA NA NA hsa-miR-374a-3p PRICKLE2 1.73882813668241 1.57901646296214e-13 -1.56077600074788 2.11863685620441e-14 MirTarget;miRNATAP -0.13041144403187 0.00111566882034706 NA NA NA hsa-miR-421 PRICKLE2 0.170525317701774 0.535277026680289 -1.56077600074788 2.11863685620441e-14 miRanda -0.250606049655561 2.58136344706684e-11 NA NA NA hsa-miR-450b-5p PRICKLE2 1.69248953402469 1.96052058003353e-07 -1.56077600074788 2.11863685620441e-14 MirTarget;mirMAP;miRNATAP -0.12051750726083 0.000232580477687486 NA NA NA hsa-miR-576-5p PRICKLE2 1.02693643167056 1.14846964470173e-06 -1.56077600074788 2.11863685620441e-14 mirMAP -0.299015548718612 2.09147606818642e-11 NA NA NA hsa-miR-589-3p PRICKLE2 1.34253876396688 1.84935927493927e-05 -1.56077600074788 2.11863685620441e-14 MirTarget -0.132439809936917 2.54052582732518e-05 NA NA NA hsa-miR-589-5p PRICKLE2 0.233778899379261 0.228477190986199 -1.56077600074788 2.11863685620441e-14 MirTarget;miRNATAP -0.163686188600079 0.00108459971421079 NA NA NA hsa-miR-590-3p PRICKLE2 0.83851360565783 0.00129224433453587 -1.56077600074788 2.11863685620441e-14 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.26695177549204 1.0703317151999e-09 NA NA NA hsa-miR-590-5p PRICKLE2 2.07441240363458 4.95240551694843e-14 -1.56077600074788 2.11863685620441e-14 MirTarget;PITA;miRanda -0.343045860860681 7.2266426394492e-17 NA NA NA hsa-miR-628-5p PRICKLE2 1.06173574237323 4.67541261016756e-06 -1.56077600074788 2.11863685620441e-14 PITA;miRNATAP -0.201506483772245 4.57922917518173e-05 NA NA NA hsa-miR-629-3p PRICKLE2 1.31892116211001 0.000114487182853678 -1.56077600074788 2.11863685620441e-14 MirTarget -0.21313428047209 9.10507570592793e-13 NA NA NA hsa-miR-7-1-3p PRICKLE2 2.61364240402652 1.98959237815786e-32 -1.56077600074788 2.11863685620441e-14 MirTarget -0.281284256799459 3.283952403161e-11 NA NA NA hsa-let-7a-3p PRKACB 0.167285443861993 0.431834813181487 -0.337490057919314 0.0956151593593903 MirTarget;mirMAP;miRNATAP -0.109621340434496 0.0264314696722877 NA NA NA hsa-miR-141-3p PRKACB 3.36993755486106 5.42939251147195e-32 -0.337490057919314 0.0956151593593903 MirTarget;TargetScan;miRNATAP -0.127873218774198 2.27329955972899e-05 NA NA NA hsa-miR-146b-5p PRKACB 1.0922867893808 5.63754607494775e-06 -0.337490057919314 0.0956151593593903 miRanda -0.16173584971976 2.34820463010476e-05 NA NA NA hsa-miR-16-2-3p PRKACB 0.503964803530872 0.0263648405197492 -0.337490057919314 0.0956151593593903 mirMAP -0.126437256197819 0.00465216057285952 NA NA NA hsa-miR-17-5p PRKACB 2.07078488653279 2.77403038572568e-19 -0.337490057919314 0.0956151593593903 TargetScan -0.146235921583623 0.000160820334409303 NA NA NA hsa-miR-182-5p PRKACB 3.21839823004635 5.13049145201115e-39 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.112248448456467 0.00121734908239389 NA NA NA hsa-miR-183-5p PRKACB 2.39247234736657 3.92444525331999e-21 -0.337490057919314 0.0956151593593903 MirTarget -0.10185724563834 0.0037757174706069 NA NA NA hsa-miR-19a-3p PRKACB 2.11776595911517 7.07663078397156e-10 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.170735517959884 5.74076627300856e-08 NA NA NA hsa-miR-19b-3p PRKACB 2.10868505662119 5.40846613768389e-17 -0.337490057919314 0.0956151593593903 miRNAWalker2_validate;MirTarget;miRNATAP -0.197277470144974 1.27039043015725e-07 NA NA NA hsa-miR-200b-3p PRKACB 1.55157578247391 4.83790020897188e-09 -0.337490057919314 0.0956151593593903 MirTarget;TargetScan -0.101454883897731 0.00336247964553013 NA NA NA hsa-miR-200c-3p PRKACB 0.380533388300368 0.0842181838538353 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.115374415768757 0.00655504187350906 NA NA NA hsa-miR-339-5p PRKACB 0.536997313601114 0.0488090394176611 -0.337490057919314 0.0956151593593903 miRanda -0.172209477372762 3.7061891291678e-07 NA NA NA hsa-miR-34a-5p PRKACB 1.40588612517769 8.60097477768592e-12 -0.337490057919314 0.0956151593593903 miRNATAP -0.249544715069385 1.25392359331725e-08 NA NA NA hsa-miR-362-5p PRKACB 0.658947634569393 0.0243306847205756 -0.337490057919314 0.0956151593593903 PITA -0.152310553896922 2.5944554975563e-06 NA NA NA hsa-miR-429 PRKACB 2.3794516574089 1.72813419703734e-13 -0.337490057919314 0.0956151593593903 MirTarget;PITA;miRanda;miRNATAP -0.120289214888389 7.31299726157361e-05 NA NA NA hsa-miR-590-5p PRKACB 2.07441240363458 4.95240551694843e-14 -0.337490057919314 0.0956151593593903 miRanda -0.106057390676399 0.00956598336443456 NA NA NA hsa-miR-93-5p PRKACB 1.50844106515467 1.83836866996875e-12 -0.337490057919314 0.0956151593593903 miRNAWalker2_validate -0.173603248772151 4.27230598908178e-05 NA NA NA hsa-miR-96-5p PRKACB 3.0381097138467 4.40362891630201e-24 -0.337490057919314 0.0956151593593903 miRNATAP -0.19117539499709 1.28710220181067e-08 NA NA NA hsa-miR-17-3p PRKCA 1.36706429551147 4.60388403547821e-13 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.2211557176846 0.000413342702730225 NA NA NA hsa-miR-181c-5p PRKCA 0.529875814537156 0.0125885822998008 -0.189679589892687 0.471078192212991 mirMAP -0.326745565499583 6.66432412436314e-09 NA NA NA hsa-miR-183-5p PRKCA 2.39247234736657 3.92444525331999e-21 -0.189679589892687 0.471078192212991 miRNATAP -0.191021307259656 2.63755654536705e-05 NA NA NA hsa-miR-186-5p PRKCA 0.852175445703945 6.88885738584309e-10 -0.189679589892687 0.471078192212991 miRNATAP -0.182809848844304 0.0364827269657349 NA NA NA hsa-miR-193b-3p PRKCA 1.10444771306846 0.000822888533401377 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.138487066621768 0.000138664149309437 NA NA NA hsa-miR-193b-5p PRKCA 0.179695858885499 0.55521472494233 -0.189679589892687 0.471078192212991 mirMAP -0.137899397693864 0.000521039895191079 NA NA NA hsa-miR-19b-1-5p PRKCA 1.71217036351784 3.28561659177495e-12 -0.189679589892687 0.471078192212991 mirMAP -0.210975845049586 0.000143708055393517 NA NA NA hsa-miR-200b-3p PRKCA 1.55157578247391 4.83790020897188e-09 -0.189679589892687 0.471078192212991 TargetScan -0.1088658423995 0.0155570891072353 NA NA NA hsa-miR-200c-3p PRKCA 0.380533388300368 0.0842181838538353 -0.189679589892687 0.471078192212991 miRNATAP -0.262911308228053 1.5097135867061e-06 NA NA NA hsa-miR-22-5p PRKCA 1.71436244278242 9.85038001236064e-15 -0.189679589892687 0.471078192212991 mirMAP -0.177526746625668 0.000829577475678236 NA NA NA hsa-miR-24-2-5p PRKCA 1.43704663046967 4.34375016509278e-11 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.114268570782096 0.0364691635457816 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-429 PRKCA 2.3794516574089 1.72813419703734e-13 -0.189679589892687 0.471078192212991 miRanda;miRNATAP -0.142853746691809 0.000293353456114152 NA NA NA hsa-miR-590-3p PRKCA 0.83851360565783 0.00129224433453587 -0.189679589892687 0.471078192212991 PITA;miRanda;mirMAP;miRNATAP -0.19448195031258 0.000455368438666445 NA NA NA hsa-miR-92a-3p PRKCA -0.136362762339122 0.493412263619364 -0.189679589892687 0.471078192212991 miRNAWalker2_validate -0.160805726714066 0.00861285946041943 NA NA NA hsa-miR-93-3p PRKCA 1.07631808403007 1.63747525692813e-05 -0.189679589892687 0.471078192212991 mirMAP -0.159060267220526 0.000935006714973491 NA NA NA hsa-miR-141-5p PRKCB 3.02575703771074 1.54385222591327e-32 -1.01521651364956 0.000234705382361064 mirMAP -0.19965194499171 1.76112086865619e-05 NA NA NA hsa-miR-200b-3p PRKCB 1.55157578247391 4.83790020897188e-09 -1.01521651364956 0.000234705382361064 MirTarget -0.139521777238666 0.00328113460432514 NA NA NA hsa-miR-200c-3p PRKCB 0.380533388300368 0.0842181838538353 -1.01521651364956 0.000234705382361064 MirTarget;miRNATAP -0.217004467533231 0.000183295321414174 NA NA NA hsa-miR-24-3p PRKCB -0.0357874587555003 0.785865078836504 -1.01521651364956 0.000234705382361064 miRNATAP -0.200930519007703 0.0424759197567277 NA NA NA hsa-miR-335-3p PRKCB 1.51116383169018 6.88553098788624e-13 -1.01521651364956 0.000234705382361064 mirMAP -0.246405652657792 3.09182980578855e-05 NA NA NA hsa-miR-429 PRKCB 2.3794516574089 1.72813419703734e-13 -1.01521651364956 0.000234705382361064 MirTarget;miRanda;miRNATAP -0.166472060253132 6.28432741975052e-05 NA NA NA hsa-miR-450b-5p PRKCB 1.69248953402469 1.96052058003353e-07 -1.01521651364956 0.000234705382361064 miRNATAP -0.183354145967975 2.13964194654069e-05 NA NA NA hsa-miR-589-3p PRKCB 1.34253876396688 1.84935927493927e-05 -1.01521651364956 0.000234705382361064 mirMAP -0.153872579100374 0.000218865142512993 NA NA NA hsa-miR-589-5p PRKCB 0.233778899379261 0.228477190986199 -1.01521651364956 0.000234705382361064 mirMAP -0.191889757915074 0.00377217964937973 NA NA NA hsa-miR-590-5p PRKCB 2.07441240363458 4.95240551694843e-14 -1.01521651364956 0.000234705382361064 miRanda -0.247831270781318 8.78932489501914e-06 NA NA NA hsa-miR-7-1-3p PRKCB 2.61364240402652 1.98959237815786e-32 -1.01521651364956 0.000234705382361064 mirMAP -0.119995650641294 0.0359252672231447 NA NA NA hsa-miR-2110 PRKCG -1.92124860612475 1.1464887721828e-12 1.66883505426905 0.000268885102920086 MirTarget -0.307845409938279 6.49952836801256e-05 NA NA NA hsa-miR-326 PRKCG -0.992397386750901 0.00335173765975096 1.66883505426905 0.000268885102920086 miRanda -0.268960075781158 1.49724165244188e-05 NA NA NA hsa-miR-335-5p PRKCG -0.466533891325811 0.0676987038122831 1.66883505426905 0.000268885102920086 miRNAWalker2_validate -0.28334410784476 0.00233636911178136 NA NA NA hsa-miR-450b-5p PRKX 1.69248953402469 1.96052058003353e-07 -0.138434262119447 0.395012462656297 mirMAP -0.119346741491602 2.11739235739311e-06 NA NA NA hsa-miR-542-3p PRKX 1.62226640768239 2.6427102465476e-10 -0.138434262119447 0.395012462656297 mirMAP -0.149271020180693 1.30948834311169e-07 NA NA NA hsa-miR-186-5p PSEN1 0.852175445703945 6.88885738584309e-10 -0.060856518124262 0.490808035333513 mirMAP -0.144555390002226 5.12969556734481e-07 NA NA NA hsa-miR-30c-5p RAC1 -0.327319105755825 0.123595832152687 0.217355195910818 0.0528286499053578 miRNAWalker2_validate -0.11419324793125 2.23761362474291e-06 NA NA NA hsa-miR-193b-3p RAC2 1.10444771306846 0.000822888533401377 -0.656275624483639 0.00297441142612925 miRNAWalker2_validate -0.112838589622127 0.000231783502607722 NA NA NA hsa-miR-125a-5p RAC3 -1.04824536696301 3.97386082850476e-07 1.82835649257478 3.33704760151114e-09 PITA -0.183541043002533 0.00831332585841968 NA NA NA hsa-miR-30c-2-3p RAC3 -3.10905250533941 6.84550165664783e-27 1.82835649257478 3.33704760151114e-09 miRNAWalker2_validate -0.370936437115312 5.24524075378395e-16 NA NA NA hsa-miR-185-5p RHOA 1.14291034858482 2.95777119743491e-13 -0.611454267658683 6.71671176904016e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.118476198992249 1.45868845487647e-05 NA NA NA hsa-miR-7-1-3p RHOA 2.61364240402652 1.98959237815786e-32 -0.611454267658683 6.71671176904016e-11 mirMAP -0.112127671880069 6.10082154871722e-09 NA NA NA hsa-miR-135b-5p ROCK1 3.25019233805845 1.95560099639034e-15 -0.495512518948934 0.00010285834164478 MirTarget -0.103999556403025 2.02018211845052e-12 NA NA NA hsa-miR-16-1-3p ROCK1 1.50034693398929 6.63958242991125e-10 -0.495512518948934 0.00010285834164478 MirTarget -0.117181689893932 7.33904353667655e-05 NA NA NA hsa-miR-199a-5p ROCK1 1.3057193856884 2.38429382751645e-08 -0.495512518948934 0.00010285834164478 miRanda -0.101642807724135 4.06641815065492e-05 NA NA NA hsa-miR-199b-5p ROCK1 2.13822205171062 4.56262988762436e-15 -0.495512518948934 0.00010285834164478 miRanda -0.101755143949641 9.8861303769902e-07 NA NA NA hsa-miR-664a-3p ROCK1 0.443077463053857 0.0214248925850984 -0.495512518948934 0.00010285834164478 mirMAP -0.158009189405496 2.07603238001394e-07 NA NA NA hsa-let-7a-3p ROCK2 0.167285443861993 0.431834813181487 -0.472681855522957 0.0066083763551485 mirMAP -0.150130294559708 0.000392125465187804 NA NA NA hsa-miR-142-3p ROCK2 3.98476449801341 1.56256182021111e-35 -0.472681855522957 0.0066083763551485 PITA;miRanda;miRNATAP -0.128436496141848 1.91759266509627e-08 NA NA NA hsa-miR-142-5p ROCK2 1.29672439149353 4.0768822158894e-06 -0.472681855522957 0.0066083763551485 PITA -0.148988795033596 9.51799466445557e-07 NA NA NA hsa-miR-17-5p ROCK2 2.07078488653279 2.77403038572568e-19 -0.472681855522957 0.0066083763551485 TargetScan -0.104496415756115 0.00178134734335757 NA NA NA hsa-miR-429 ROCK2 2.3794516574089 1.72813419703734e-13 -0.472681855522957 0.0066083763551485 PITA;miRanda;miRNATAP -0.104412898426938 6.36897086371469e-05 NA NA NA hsa-miR-500a-5p ROCK2 0.648155655714409 0.0104657432932038 -0.472681855522957 0.0066083763551485 mirMAP -0.172612553343475 8.20603856054942e-08 NA NA NA hsa-miR-590-3p ROCK2 0.83851360565783 0.00129224433453587 -0.472681855522957 0.0066083763551485 miRanda;mirMAP -0.108301017398064 0.00329023217986682 NA NA NA hsa-miR-140-3p SENP2 -1.11373309124537 8.35257079443689e-14 0.0851704909525699 0.508681221846179 mirMAP -0.157013881922539 5.15107797194575e-05 NA NA NA hsa-miR-30d-5p SENP2 -0.920901858717441 3.50898334321668e-05 0.0851704909525699 0.508681221846179 miRNAWalker2_validate -0.10985832934529 2.94619923911059e-05 NA NA NA hsa-miR-146a-5p SFRP1 0.684701497250824 0.0105316554224149 -2.08752885738513 5.38679141051593e-05 MirTarget -0.19598930251717 0.0332604030385873 NA NA NA hsa-miR-146b-5p SFRP1 1.0922867893808 5.63754607494775e-06 -2.08752885738513 5.38679141051593e-05 MirTarget -0.52942072100834 6.32795389015505e-08 NA NA NA hsa-miR-16-1-3p SFRP1 1.50034693398929 6.63958242991125e-10 -2.08752885738513 5.38679141051593e-05 MirTarget -0.484182161826445 5.65968227514651e-05 NA NA NA hsa-miR-182-5p SFRP1 3.21839823004635 5.13049145201115e-39 -2.08752885738513 5.38679141051593e-05 mirMAP -0.270831612243815 0.00245046517911601 NA NA NA hsa-miR-19b-1-5p SFRP1 1.71217036351784 3.28561659177495e-12 -2.08752885738513 5.38679141051593e-05 MirTarget -0.283711198217666 0.0102198788993858 NA NA NA hsa-miR-203a-3p SFRP1 1.06866854356847 0.00389979689199624 -2.08752885738513 5.38679141051593e-05 MirTarget -0.153399601527414 0.0175685996823251 NA NA NA hsa-miR-29a-5p SFRP1 1.89519956688438 1.03453349363915e-11 -2.08752885738513 5.38679141051593e-05 mirMAP -0.549369602929202 3.46808310125807e-08 NA NA NA hsa-miR-501-5p SFRP1 0.411357595674671 0.10435288464149 -2.08752885738513 5.38679141051593e-05 mirMAP -0.217021488430223 0.0223831328841273 NA NA NA hsa-miR-7-1-3p SFRP1 2.61364240402652 1.98959237815786e-32 -2.08752885738513 5.38679141051593e-05 MirTarget;mirMAP -0.226682623342799 0.0347381830314205 NA NA NA hsa-miR-96-5p SFRP1 3.0381097138467 4.40362891630201e-24 -2.08752885738513 5.38679141051593e-05 mirMAP -0.377228057292009 1.50643419827674e-05 NA NA NA hsa-miR-455-5p SFRP2 1.36946341828134 5.05118627562807e-08 0.381552977921631 0.4088930245524 miRanda -0.219149858513044 0.0235565691585629 NA NA NA hsa-miR-144-5p SFRP4 -1.3899604395726 0.000237414824562107 0.502900557158704 0.215273865000971 MirTarget -0.231374332123845 2.00145037239657e-06 NA NA NA hsa-miR-26b-5p SFRP4 0.72362441215247 4.7794659748036e-05 0.502900557158704 0.215273865000971 miRNAWalker2_validate -0.306869750257348 0.00345714161336382 NA NA NA hsa-miR-532-5p SFRP4 0.576620898517708 0.0023245812680956 0.502900557158704 0.215273865000971 MirTarget -0.293705784842898 0.00297601608882942 NA NA NA hsa-miR-454-3p SKP1 1.49453641052169 4.46235742871434e-09 -0.173813980331543 0.121763281653782 MirTarget -0.119595485764239 4.0867597278602e-07 NA NA NA hsa-miR-146b-5p SMAD2 1.0922867893808 5.63754607494775e-06 -0.303598966729702 0.0159514222596008 mirMAP -0.124747200476988 1.31693635704313e-07 NA NA NA hsa-miR-181a-5p SMAD2 -0.375429731222937 0.0562142867129802 -0.303598966729702 0.0159514222596008 mirMAP -0.100760447867236 0.000646706434692283 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 0.668793269169928 0.000239998092406404 -0.303598966729702 0.0159514222596008 mirMAP -0.12955227917762 4.345362949562e-05 NA NA NA hsa-miR-361-5p SMAD2 0.21454431962475 0.0800957579368424 -0.303598966729702 0.0159514222596008 MirTarget -0.182189359256109 0.000148630910578159 NA NA NA hsa-miR-362-5p SMAD2 0.658947634569393 0.0243306847205756 -0.303598966729702 0.0159514222596008 mirMAP -0.106469252000328 1.13100823986564e-07 NA NA NA hsa-miR-450b-5p SMAD2 1.69248953402469 1.96052058003353e-07 -0.303598966729702 0.0159514222596008 mirMAP -0.113530038108809 4.67112154448759e-09 NA NA NA hsa-miR-501-5p SMAD2 0.411357595674671 0.10435288464149 -0.303598966729702 0.0159514222596008 mirMAP -0.107502701254072 2.2464520729965e-06 NA NA NA hsa-miR-532-5p SMAD2 0.576620898517708 0.0023245812680956 -0.303598966729702 0.0159514222596008 MirTarget -0.12142437459949 6.98911386285879e-05 NA NA NA hsa-miR-542-3p SMAD2 1.62226640768239 2.6427102465476e-10 -0.303598966729702 0.0159514222596008 PITA -0.122748876655511 2.00012298893724e-08 NA NA NA hsa-miR-16-5p SMAD3 0.749619098384047 4.11649450706988e-06 -0.104935015261858 0.513761397736816 MirTarget -0.134568029960143 0.00296658337663515 NA NA NA hsa-miR-17-5p SMAD3 2.07078488653279 2.77403038572568e-19 -0.104935015261858 0.513761397736816 miRNAWalker2_validate -0.114025973647647 0.000202733731547773 NA NA NA hsa-miR-186-5p SMAD3 0.852175445703945 6.88885738584309e-10 -0.104935015261858 0.513761397736816 mirMAP -0.108346518573167 0.0420313683849285 NA NA NA hsa-miR-30d-3p SMAD3 0.00396376345349925 0.986457040013182 -0.104935015261858 0.513761397736816 mirMAP -0.133925007589118 0.000158089768147608 NA NA NA hsa-miR-335-3p SMAD3 1.51116383169018 6.88553098788624e-13 -0.104935015261858 0.513761397736816 mirMAP -0.132872113827048 0.000101143487310671 NA NA NA hsa-miR-335-5p SMAD3 -0.466533891325811 0.0676987038122831 -0.104935015261858 0.513761397736816 miRNAWalker2_validate -0.113837951066797 0.000426295808318841 NA NA NA hsa-miR-146b-5p SMAD4 1.0922867893808 5.63754607494775e-06 -0.515653744933977 9.47137433628545e-06 PITA;miRanda;miRNATAP -0.109392210828109 6.88759131517055e-07 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-155-5p SMAD4 0.813513839059142 0.000608282725633232 -0.515653744933977 9.47137433628545e-06 miRNAWalker2_validate -0.11758126013491 1.55919717084934e-07 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-199a-5p SMAD4 1.3057193856884 2.38429382751645e-08 -0.515653744933977 9.47137433628545e-06 miRNAWalker2_validate;miRTarBase;miRanda -0.118493107916432 1.4071018929418e-07 NA NA NA hsa-miR-214-5p SMAD4 0.722336234279023 0.00539148054719041 -0.515653744933977 9.47137433628545e-06 MirTarget -0.114669708727048 2.13522290338095e-08 NA NA NA hsa-miR-27a-3p SMAD4 0.433402568013802 0.00737164631768323 -0.515653744933977 9.47137433628545e-06 MirTarget -0.144020279947672 1.5900674575152e-05 NA NA NA hsa-miR-28-5p SMAD4 1.19639196514745 4.59365801666536e-18 -0.515653744933977 9.47137433628545e-06 miRanda;miRNATAP -0.110138329815836 0.00382181011203322 NA NA NA hsa-miR-34a-5p SMAD4 1.40588612517769 8.60097477768592e-12 -0.515653744933977 9.47137433628545e-06 miRNATAP -0.1876322269981 6.61051288734246e-14 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-361-5p SMAD4 0.21454431962475 0.0800957579368424 -0.515653744933977 9.47137433628545e-06 mirMAP -0.157388316044875 0.000434500601175461 NA NA NA hsa-miR-450b-5p SMAD4 1.69248953402469 1.96052058003353e-07 -0.515653744933977 9.47137433628545e-06 mirMAP -0.125104732481319 2.70976048720848e-12 NA NA NA hsa-miR-454-3p SMAD4 1.49453641052169 4.46235742871434e-09 -0.515653744933977 9.47137433628545e-06 miRNAWalker2_validate;miRNATAP -0.103755273712557 2.90984012875118e-05 NA NA NA hsa-miR-590-5p SMAD4 2.07441240363458 4.95240551694843e-14 -0.515653744933977 9.47137433628545e-06 miRanda -0.127332971579553 5.14267821558811e-08 NA NA NA hsa-miR-141-3p SOX17 3.36993755486106 5.42939251147195e-32 -2.90340391018971 1.64785019664998e-29 TargetScan -0.285948067796979 1.23755538797905e-12 22921431 Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer; MicroRNA 141 was also found to down-regulate SOX17 expression and activate the WNT signal pathway esophageal cancer hsa-miR-421 SOX17 0.170525317701774 0.535277026680289 -2.90340391018971 1.64785019664998e-29 miRanda -0.191293805956964 0.000125986464716775 NA NA NA hsa-miR-542-3p SOX17 1.62226640768239 2.6427102465476e-10 -2.90340391018971 1.64785019664998e-29 miRanda;miRNATAP -0.213057328233169 9.31611511127352e-06 NA NA NA hsa-miR-590-3p SOX17 0.83851360565783 0.00129224433453587 -2.90340391018971 1.64785019664998e-29 miRanda;miRNATAP -0.244074122874333 2.40936299962558e-05 NA NA NA hsa-miR-590-5p SOX17 2.07441240363458 4.95240551694843e-14 -2.90340391018971 1.64785019664998e-29 miRanda -0.299386450942819 4.86551248104081e-08 NA NA NA hsa-miR-181a-5p TBL1X -0.375429731222937 0.0562142867129802 0.710446347289593 0.000189201262675257 MirTarget;miRNATAP -0.129823302761357 0.003917419728227 NA NA NA hsa-miR-30a-3p TBL1X -2.54042202792785 2.9111625410859e-18 0.710446347289593 0.000189201262675257 mirMAP -0.138116547122296 1.69177897234132e-06 NA NA NA hsa-miR-30c-2-3p TBL1X -3.10905250533941 6.84550165664783e-27 0.710446347289593 0.000189201262675257 MirTarget -0.135070958312807 2.09089910561681e-06 NA NA NA hsa-miR-30d-3p TBL1X 0.00396376345349925 0.986457040013182 0.710446347289593 0.000189201262675257 mirMAP -0.101566310445313 0.016885802625955 NA NA NA hsa-miR-30e-3p TBL1X -0.104420043859122 0.526240453209293 0.710446347289593 0.000189201262675257 mirMAP -0.147205585626968 0.00644892316331096 NA NA NA hsa-miR-140-3p TBL1XR1 -1.11373309124537 8.35257079443689e-14 0.530112639085332 1.77342574169206e-06 PITA -0.20096693148629 1.7633979341536e-09 NA NA NA hsa-miR-145-3p TBL1XR1 -0.68545633476888 0.000680820366475469 0.530112639085332 1.77342574169206e-06 MirTarget -0.134125134058061 1.03577853649442e-07 NA NA NA hsa-miR-181a-5p TBL1XR1 -0.375429731222937 0.0562142867129802 0.530112639085332 1.77342574169206e-06 mirMAP -0.108821530566559 3.14926505225963e-05 NA NA NA hsa-miR-181c-5p TBL1XR1 0.529875814537156 0.0125885822998008 0.530112639085332 1.77342574169206e-06 MirTarget;mirMAP -0.106007204478004 1.10402527674774e-05 NA NA NA hsa-miR-30c-5p TBL1XR1 -0.327319105755825 0.123595832152687 0.530112639085332 1.77342574169206e-06 miRNAWalker2_validate -0.142424609088612 2.68105323471164e-09 NA NA NA hsa-miR-497-5p TBL1XR1 -0.0546347378264729 0.786205564901684 0.530112639085332 1.77342574169206e-06 MirTarget -0.131858256119385 2.15666467320678e-07 NA NA NA hsa-miR-500a-5p TBL1XR1 0.648155655714409 0.0104657432932038 0.530112639085332 1.77342574169206e-06 MirTarget -0.102845984982082 6.50234436554384e-07 NA NA NA hsa-miR-501-3p TBL1XR1 -0.0405952693028064 0.866802243505833 0.530112639085332 1.77342574169206e-06 PITA -0.100330388751915 2.108646399315e-06 NA NA NA hsa-miR-664a-3p TBL1XR1 0.443077463053857 0.0214248925850984 0.530112639085332 1.77342574169206e-06 mirMAP -0.123335904788684 3.59203492145494e-06 NA NA NA hsa-miR-130b-5p TCF7L1 1.53645187062942 1.10498816261505e-08 -0.891121154525344 0.00171182601810095 MirTarget -0.13195811384953 0.0061200745074429 NA NA NA hsa-miR-142-5p TCF7L1 1.29672439149353 4.0768822158894e-06 -0.891121154525344 0.00171182601810095 PITA -0.131361541543027 0.00890316043023296 NA NA NA hsa-miR-505-5p TCF7L1 0.77207328399883 0.00479562389564013 -0.891121154525344 0.00171182601810095 miRNATAP -0.108534725256487 0.0236428772021091 NA NA NA hsa-miR-590-3p TCF7L1 0.83851360565783 0.00129224433453587 -0.891121154525344 0.00171182601810095 PITA;miRanda;miRNATAP -0.2260698525085 0.000170663252280023 NA NA NA hsa-miR-93-5p TCF7L1 1.50844106515467 1.83836866996875e-12 -0.891121154525344 0.00171182601810095 MirTarget -0.143087930873522 0.0173654321970329 NA NA NA hsa-let-7g-3p TCF7L2 2.38336858943031 4.8771148585792e-17 -0.440319687404722 0.00166470235681049 MirTarget;miRNATAP -0.126291442849105 5.3667323482943e-09 NA NA NA hsa-miR-132-3p TCF7L2 0.0122601212105202 0.934032846062939 -0.440319687404722 0.00166470235681049 miRNATAP -0.154343299195605 0.000466067222071514 NA NA NA hsa-miR-155-5p TCF7L2 0.813513839059142 0.000608282725633232 -0.440319687404722 0.00166470235681049 MirTarget;miRNATAP -0.174255291736268 6.16077982708104e-11 NA NA NA hsa-miR-183-5p TCF7L2 2.39247234736657 3.92444525331999e-21 -0.440319687404722 0.00166470235681049 MirTarget;miRNATAP -0.12984284690733 7.14979721612215e-08 NA NA NA hsa-miR-186-5p TCF7L2 0.852175445703945 6.88885738584309e-10 -0.440319687404722 0.00166470235681049 mirMAP -0.15438674683179 0.000891121529737024 NA NA NA hsa-miR-20a-3p TCF7L2 2.51803599558247 4.92479325298629e-13 -0.440319687404722 0.00166470235681049 MirTarget;miRNATAP -0.125307698569328 5.63624873975403e-08 NA NA NA hsa-miR-24-2-5p TCF7L2 1.43704663046967 4.34375016509278e-11 -0.440319687404722 0.00166470235681049 MirTarget -0.159160974541593 3.05492350459177e-08 NA NA NA hsa-miR-342-3p TCF7L2 -0.128691966564961 0.561034080130801 -0.440319687404722 0.00166470235681049 miRanda -0.183821210156152 1.73100538878158e-10 NA NA NA hsa-miR-542-3p TCF7L2 1.62226640768239 2.6427102465476e-10 -0.440319687404722 0.00166470235681049 miRanda -0.11950359213415 1.05886309370529e-06 NA NA NA hsa-miR-590-3p TCF7L2 0.83851360565783 0.00129224433453587 -0.440319687404722 0.00166470235681049 miRanda -0.119192382595226 5.43448019342063e-05 NA NA NA hsa-miR-942-5p TCF7L2 -0.0372813055050076 0.870631058767894 -0.440319687404722 0.00166470235681049 MirTarget -0.117378020078121 5.00553323457891e-05 NA NA NA hsa-miR-96-5p TCF7L2 3.0381097138467 4.40362891630201e-24 -0.440319687404722 0.00166470235681049 MirTarget;TargetScan;miRNATAP -0.14787544239925 1.79995050445034e-10 NA NA NA hsa-miR-139-5p VANGL1 -2.26625553116965 7.22375119369519e-16 0.482522450244504 0.00121744978200244 miRanda -0.10182463947012 1.58219892980101e-05 NA NA NA hsa-miR-146a-5p VANGL1 0.684701497250824 0.0105316554224149 0.482522450244504 0.00121744978200244 mirMAP -0.104860765388499 6.47575625825691e-05 NA NA NA hsa-miR-146b-5p VANGL1 1.0922867893808 5.63754607494775e-06 0.482522450244504 0.00121744978200244 miRNATAP -0.112947268524328 6.4881898351089e-05 NA NA NA hsa-miR-148a-3p VANGL1 2.30885799126944 1.95226081368985e-21 0.482522450244504 0.00121744978200244 mirMAP -0.106648953158187 7.87758638835079e-05 NA NA NA hsa-miR-148b-3p VANGL1 0.483970528590224 0.0026495409465901 0.482522450244504 0.00121744978200244 mirMAP -0.104831213876328 0.0149379338308271 NA NA NA hsa-miR-16-5p VANGL1 0.749619098384047 4.11649450706988e-06 0.482522450244504 0.00121744978200244 mirMAP -0.146020168541547 0.000536364284172832 NA NA NA hsa-miR-195-5p VANGL1 -1.01577502605386 4.80814718341729e-05 0.482522450244504 0.00121744978200244 mirMAP -0.114490338397658 6.89533156153856e-05 NA NA NA hsa-miR-26a-5p VANGL1 -0.126411409001078 0.440028840408711 0.482522450244504 0.00121744978200244 mirMAP -0.163660052828943 0.000110599784973222 NA NA NA hsa-miR-26b-5p VANGL1 0.72362441215247 4.7794659748036e-05 0.482522450244504 0.00121744978200244 miRNAWalker2_validate;mirMAP -0.168419344887538 1.18111978867899e-05 NA NA NA hsa-miR-27b-3p VANGL1 0.236438984240408 0.12263510345883 0.482522450244504 0.00121744978200244 miRNATAP -0.104893775951213 0.0212283045233944 NA NA NA hsa-miR-320a VANGL1 -0.961144925954715 1.62478794429204e-08 0.482522450244504 0.00121744978200244 mirMAP -0.132535100305259 0.00094620885241237 NA NA NA hsa-miR-454-3p VANGL1 1.49453641052169 4.46235742871434e-09 0.482522450244504 0.00121744978200244 mirMAP -0.123419425860438 0.000101053514501907 NA NA NA hsa-miR-664a-3p VANGL1 0.443077463053857 0.0214248925850984 0.482522450244504 0.00121744978200244 mirMAP -0.212972374438555 1.70187294195203e-09 NA NA NA hsa-miR-146b-3p VANGL2 -0.808296168180355 0.000870284326590347 0.131631838268175 0.732678462615205 PITA -0.150195677089424 0.0396494671018857 NA NA NA hsa-miR-362-5p VANGL2 0.658947634569393 0.0243306847205756 0.131631838268175 0.732678462615205 mirMAP -0.158984709771889 0.0105366976060691 NA NA NA hsa-miR-511-5p VANGL2 -0.299232651841262 0.292871281649728 0.131631838268175 0.732678462615205 MirTarget -0.181896796180526 0.00355002957391173 NA NA NA hsa-miR-127-5p WIF1 2.05164948368907 3.61318574536718e-09 -5.68437329541209 2.64369382414593e-13 PITA;miRNATAP -0.491614161322484 1.88198280801827e-06 NA NA NA hsa-miR-28-5p WIF1 1.19639196514745 4.59365801666536e-18 -5.68437329541209 2.64369382414593e-13 miRanda -0.751184363123977 0.00387124533394718 NA NA NA hsa-miR-421 WIF1 0.170525317701774 0.535277026680289 -5.68437329541209 2.64369382414593e-13 miRanda -0.28851761116604 0.0481686623917201 NA NA NA hsa-miR-590-3p WIF1 0.83851360565783 0.00129224433453587 -5.68437329541209 2.64369382414593e-13 PITA;miRanda;mirMAP -0.522932753335165 0.00196303246166186 NA NA NA hsa-miR-19a-3p WNT10A 2.11776595911517 7.07663078397156e-10 0.980923245916377 0.0256012470255502 MirTarget -0.208517193720384 0.00257863029042926 NA NA NA hsa-miR-19b-3p WNT10A 2.10868505662119 5.40846613768389e-17 0.980923245916377 0.0256012470255502 MirTarget -0.256769302462553 0.00174324980173983 NA NA NA hsa-miR-335-5p WNT10B -0.466533891325811 0.0676987038122831 1.15088038731375 0.000605834407682622 miRNAWalker2_validate -0.196457776774209 0.00395664338130929 NA NA NA hsa-miR-98-5p WNT10B 1.170602085804 1.09900501665229e-08 1.15088038731375 0.000605834407682622 miRNAWalker2_validate -0.168360616194815 0.0289580275761912 NA NA NA hsa-miR-590-3p WNT11 0.83851360565783 0.00129224433453587 -2.02143786067022 1.52557188447296e-07 miRanda -0.373242513422953 5.34584852988355e-06 NA NA NA hsa-miR-146b-3p WNT16 -0.808296168180355 0.000870284326590347 0.421312581058213 0.381219057601469 MirTarget -0.236129763131591 0.00951773685461053 NA NA NA hsa-miR-181a-5p WNT16 -0.375429731222937 0.0562142867129802 0.421312581058213 0.381219057601469 miRNAWalker2_validate;MirTarget -0.418738717276526 0.000206105344005426 NA NA NA hsa-miR-181b-5p WNT16 0.668793269169928 0.000239998092406404 0.421312581058213 0.381219057601469 MirTarget -0.40294447968335 0.000916083429841582 NA NA NA hsa-miR-338-3p WNT16 0.726843067232002 0.0506251324215494 0.421312581058213 0.381219057601469 miRanda -0.2029582323772 0.00062342767632246 NA NA NA hsa-miR-324-5p WNT2 1.06955541886548 5.39722006604758e-05 -1.62099341554492 1.02036799041017e-06 miRanda -0.225117495213621 9.68444141615679e-05 NA NA NA hsa-miR-335-3p WNT2 1.51116383169018 6.88553098788624e-13 -1.62099341554492 1.02036799041017e-06 mirMAP -0.424763785809356 1.9482456471186e-09 NA NA NA hsa-miR-362-3p WNT2 0.194097672030785 0.52808475179225 -1.62099341554492 1.02036799041017e-06 miRanda -0.143184503527761 0.0230334020912891 NA NA NA hsa-miR-450b-5p WNT2 1.69248953402469 1.96052058003353e-07 -1.62099341554492 1.02036799041017e-06 miRNATAP -0.136352096158509 0.00934430218904433 NA NA NA hsa-miR-532-5p WNT2 0.576620898517708 0.0023245812680956 -1.62099341554492 1.02036799041017e-06 miRNATAP -0.204839366964784 0.0123503561148401 NA NA NA hsa-miR-590-3p WNT2 0.83851360565783 0.00129224433453587 -1.62099341554492 1.02036799041017e-06 miRanda;mirMAP -0.196505859855445 0.00563410484574588 NA NA NA hsa-miR-624-5p WNT2 -0.0554776050468686 0.829845479813552 -1.62099341554492 1.02036799041017e-06 MirTarget -0.161276974229067 0.0168741000209198 NA NA NA hsa-miR-130b-3p WNT2B 1.83046548750752 5.04753914574694e-13 -1.78890659702403 3.23609097451353e-13 MirTarget -0.340760827768826 1.27877889985709e-13 NA NA NA hsa-miR-186-5p WNT2B 0.852175445703945 6.88885738584309e-10 -1.78890659702403 3.23609097451353e-13 mirMAP -0.171888486063258 0.0403929170341571 NA NA NA hsa-miR-301a-3p WNT2B 2.70198002906399 1.56420889710984e-14 -1.78890659702403 3.23609097451353e-13 MirTarget -0.180115992461543 5.05894310905406e-06 NA NA NA hsa-miR-454-3p WNT2B 1.49453641052169 4.46235742871434e-09 -1.78890659702403 3.23609097451353e-13 MirTarget -0.194270451419003 0.000290210653240505 NA NA NA hsa-miR-576-5p WNT2B 1.02693643167056 1.14846964470173e-06 -1.78890659702403 3.23609097451353e-13 mirMAP -0.165797705305477 0.00238180132947588 NA NA NA hsa-miR-1-3p WNT3 -1.48412019995919 0.000242034342580425 1.72385836258332 7.02627659505305e-11 MirTarget -0.115978938696651 0.000481856119405777 NA NA NA hsa-miR-146a-5p WNT3 0.684701497250824 0.0105316554224149 1.72385836258332 7.02627659505305e-11 MirTarget -0.180302613220747 0.000145074184388495 NA NA NA hsa-miR-214-3p WNT3 -1.1136198715556 3.52054933799089e-05 1.72385836258332 7.02627659505305e-11 MirTarget -0.180986641633061 7.6059663873487e-05 NA NA NA hsa-miR-215-5p WNT3 0.116505586532384 0.8384722675454 1.72385836258332 7.02627659505305e-11 miRNAWalker2_validate -0.102190911979834 4.37215917167493e-05 NA NA NA hsa-miR-335-5p WNT3 -0.466533891325811 0.0676987038122831 1.72385836258332 7.02627659505305e-11 miRNAWalker2_validate -0.118970779838107 0.0295475727779984 NA NA NA hsa-miR-361-5p WNT3 0.21454431962475 0.0800957579368424 1.72385836258332 7.02627659505305e-11 MirTarget;PITA;miRanda;miRNATAP -0.258200174627132 0.0126630971053305 NA NA NA hsa-miR-362-3p WNT3 0.194097672030785 0.52808475179225 1.72385836258332 7.02627659505305e-11 PITA;miRanda;miRNATAP -0.109377713829328 0.0310257629765601 NA NA NA hsa-miR-374a-5p WNT3 -0.197027254874826 0.298080902192861 1.72385836258332 7.02627659505305e-11 MirTarget -0.270326406605983 0.000253972455169089 NA NA NA hsa-miR-374b-5p WNT3 0.474691035780475 0.0109217471394203 1.72385836258332 7.02627659505305e-11 MirTarget -0.227038416164753 0.00129354407838489 NA NA NA hsa-miR-107 WNT3A 0.658676029898313 5.11480446318819e-07 -5.44957058224664 2.48610908209879e-25 MirTarget;PITA;miRanda;miRNATAP -0.602191379255807 0.00204464357053535 NA NA NA hsa-miR-128-3p WNT3A 1.03509868349735 2.11606310588315e-10 -5.44957058224664 2.48610908209879e-25 miRNAWalker2_validate -0.728776208229076 2.12961409810896e-06 27341528 AurkA controls self renewal of breast cancer initiating cells promoting wnt3a stabilization through suppression of miR 128; Interestingly we found that AurkA suppressed the expression of miR-128 inhibitor of wnt3a mRNA stabilization breast cancer hsa-miR-331-3p WNT3A 0.648841966086413 0.00576420872256978 -5.44957058224664 2.48610908209879e-25 mirMAP -0.29884516924688 0.00591831494705552 NA NA NA hsa-miR-424-5p WNT3A 1.26485330287919 6.1498991028257e-06 -5.44957058224664 2.48610908209879e-25 MirTarget;miRNATAP -0.297073502202942 0.000997929106475519 NA NA NA hsa-miR-9-5p WNT3A 4.99250901331516 2.59132733422801e-19 -5.44957058224664 2.48610908209879e-25 mirMAP -0.213620822045756 9.54678202540892e-07 NA NA NA hsa-miR-126-5p WNT5A 0.851637714492907 0.000391373420568359 -0.372121221213175 0.193057277928512 mirMAP -0.151248062725371 0.00563235728513554 NA NA NA hsa-miR-141-3p WNT5A 3.36993755486106 5.42939251147195e-32 -0.372121221213175 0.193057277928512 TargetScan -0.125793324099707 0.00331852934102782 NA NA NA hsa-miR-142-3p WNT5A 3.98476449801341 1.56256182021111e-35 -0.372121221213175 0.193057277928512 miRanda -0.115944016531076 0.00223771752270671 NA NA NA hsa-miR-155-5p WNT5A 0.813513839059142 0.000608282725633232 -0.372121221213175 0.193057277928512 miRNAWalker2_validate;mirMAP -0.143815735512937 0.00936896648272965 NA NA NA hsa-miR-15b-3p WNT5A 0.804736041893915 0.000400279611457186 -0.372121221213175 0.193057277928512 mirMAP -0.27043439598839 7.90998328619875e-06 NA NA NA hsa-miR-16-2-3p WNT5A 0.503964803530872 0.0263648405197492 -0.372121221213175 0.193057277928512 MirTarget;mirMAP -0.373377688750202 1.87980527171712e-09 NA NA NA hsa-miR-16-5p WNT5A 0.749619098384047 4.11649450706988e-06 -0.372121221213175 0.193057277928512 miRNAWalker2_validate -0.268804385552065 0.000862585179250393 NA NA NA hsa-miR-186-5p WNT5A 0.852175445703945 6.88885738584309e-10 -0.372121221213175 0.193057277928512 miRNAWalker2_validate;mirMAP;miRNATAP -0.417054301807237 9.65966030008268e-06 NA NA NA hsa-miR-29a-5p WNT5A 1.89519956688438 1.03453349363915e-11 -0.372121221213175 0.193057277928512 mirMAP -0.261183965471408 1.91826113480268e-06 NA NA NA hsa-miR-330-5p WNT5A 0.168520831101569 0.336433937906706 -0.372121221213175 0.193057277928512 miRanda -0.274622273940661 0.000275442864491591 NA NA NA hsa-miR-421 WNT5A 0.170525317701774 0.535277026680289 -0.372121221213175 0.193057277928512 miRanda -0.196624128752936 0.000152464264404546 NA NA NA hsa-miR-576-5p WNT5A 1.02693643167056 1.14846964470173e-06 -0.372121221213175 0.193057277928512 mirMAP -0.395707662531266 7.42053392121266e-11 NA NA NA hsa-miR-582-5p WNT5A 1.08286181406653 0.00149040450161757 -0.372121221213175 0.193057277928512 miRNATAP -0.235280095327202 1.35931910686728e-09 NA NA NA hsa-miR-590-3p WNT5A 0.83851360565783 0.00129224433453587 -0.372121221213175 0.193057277928512 miRanda;mirMAP;miRNATAP -0.160395547617788 0.00800150886159335 NA NA NA hsa-miR-7-1-3p WNT5A 2.61364240402652 1.98959237815786e-32 -0.372121221213175 0.193057277928512 mirMAP -0.239522398062042 4.22941459082507e-05 NA NA NA hsa-miR-92a-3p WNT5A -0.136362762339122 0.493412263619364 -0.372121221213175 0.193057277928512 miRNAWalker2_validate -0.355450854560077 6.47407085500391e-08 NA NA NA hsa-miR-107 WNT7A 0.658676029898313 5.11480446318819e-07 -4.45137691541241 9.35879470799359e-12 MirTarget;miRanda -1.03715758348073 9.71742260378246e-06 NA NA NA hsa-miR-15a-5p WNT7A 1.62575353599172 1.55312121019827e-19 -4.45137691541241 9.35879470799359e-12 MirTarget -0.371632511479924 0.0248747242731756 NA NA NA hsa-miR-16-5p WNT7A 0.749619098384047 4.11649450706988e-06 -4.45137691541241 9.35879470799359e-12 MirTarget -0.548666659996717 0.00371402269827223 NA NA NA hsa-miR-374a-3p WNT7A 1.73882813668241 1.57901646296214e-13 -4.45137691541241 9.35879470799359e-12 MirTarget -0.323796942636668 0.011168985128542 NA NA NA hsa-miR-424-5p WNT7A 1.26485330287919 6.1498991028257e-06 -4.45137691541241 9.35879470799359e-12 MirTarget -0.285734864631646 0.00887697958116401 NA NA NA hsa-miR-590-3p WNT7A 0.83851360565783 0.00129224433453587 -4.45137691541241 9.35879470799359e-12 miRanda -0.293080498972486 0.0387040936221804 NA NA NA hsa-miR-106b-5p WNT7B 1.47447672652218 1.32004094930462e-13 0.452362236585075 0.156970109058151 mirMAP -0.232328578391748 0.00128070505061169 NA NA NA hsa-miR-1226-3p WNT7B -1.00799676115747 0.00514693761539554 0.452362236585075 0.156970109058151 mirMAP -0.160168308487223 0.000759470342513103 NA NA NA hsa-miR-330-5p WNT7B 0.168520831101569 0.336433937906706 0.452362236585075 0.156970109058151 MirTarget;miRanda -0.256154684864363 0.00246766804709769 NA NA NA hsa-miR-335-5p WNT7B -0.466533891325811 0.0676987038122831 0.452362236585075 0.156970109058151 miRNAWalker2_validate -0.24585218224077 0.000133678965329474 NA NA NA hsa-miR-940 WNT7B 0.011138136211269 0.974925352379525 0.452362236585075 0.156970109058151 mirMAP -0.106674328242715 0.022515388938786 NA NA NA hsa-miR-148a-3p WNT9A 2.30885799126944 1.95226081368985e-21 -1.70715193650801 1.03413487994031e-08 mirMAP -0.118401932108754 0.031599834396301 NA NA NA hsa-miR-148b-3p WNT9A 0.483970528590224 0.0026495409465901 -1.70715193650801 1.03413487994031e-08 mirMAP -0.194174488657514 0.0262464076754194 NA NA NA hsa-miR-16-5p WNT9A 0.749619098384047 4.11649450706988e-06 -1.70715193650801 1.03413487994031e-08 mirMAP -0.26609532840731 0.00188366377751934 NA NA NA hsa-miR-28-5p WNT9A 1.19639196514745 4.59365801666536e-18 -1.70715193650801 1.03413487994031e-08 mirMAP -0.413487846679742 2.50403745773092e-05 NA NA NA hsa-miR-32-5p WNT9A 0.876853679269853 6.04859399018691e-05 -1.70715193650801 1.03413487994031e-08 mirMAP -0.166936780470949 0.0157667793095828 NA NA NA