miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106b-5p AKT3 2.80565545918114 1.14547999022566e-09 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.411504731855899 9.49650030459631e-06 NA NA NA hsa-miR-142-3p AKT3 4.35304505457969 3.10014573651358e-10 -3.32677676487603 1.45486698220293e-05 miRanda -0.161022651130634 0.00933730307368185 NA NA NA hsa-miR-15a-5p AKT3 2.0535411006904 1.91108976398046e-06 -3.32677676487603 1.45486698220293e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.374578960806042 0.000213935533400346 NA NA NA hsa-miR-15b-5p AKT3 3.32329949959268 8.40210501034588e-13 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.254367737995205 0.00570754876367863 NA NA NA hsa-miR-16-5p AKT3 2.93575808220754 2.15436817162977e-10 -3.32677676487603 1.45486698220293e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309870666150618 0.000864570425925272 NA NA NA hsa-miR-29b-3p AKT3 0.666547117072858 0.234055379278093 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.283935483475042 0.000311340903637634 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 2.14185373842821 0.0609400502269891 -3.32677676487603 1.45486698220293e-05 mirMAP -0.221762461081726 2.87831776854007e-06 NA NA NA hsa-miR-362-3p AKT3 0.679952485897744 0.226148468488576 -3.32677676487603 1.45486698220293e-05 miRanda -0.254988730314174 0.00123561088951897 NA NA NA hsa-miR-501-3p AKT3 1.72239979688923 0.0075900263732748 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.18288683695833 0.00732967244086728 NA NA NA hsa-miR-93-5p AKT3 2.65964181833033 2.58315947526774e-08 -3.32677676487603 1.45486698220293e-05 miRNATAP -0.334744595445174 0.000214241376596223 NA NA NA hsa-miR-582-5p CHP2 0.685177900016753 0.447761540297692 1.48109800587141 0.509563690322669 miRNATAP -0.415938249783453 0.0031281915626761 NA NA NA hsa-miR-130a-5p KDR 1.58028512890005 0.024346333013728 -3.78753480302955 5.10405108636238e-08 mirMAP -0.165311550111567 0.00459402915226011 NA NA NA hsa-miR-149-5p KDR 1.18551753240939 0.197439607622379 -3.78753480302955 5.10405108636238e-08 miRNATAP -0.16823133416391 0.000108425090785733 NA NA NA hsa-miR-15a-5p KDR 2.0535411006904 1.91108976398046e-06 -3.78753480302955 5.10405108636238e-08 miRNATAP -0.339778633619659 0.000238480183582385 NA NA NA hsa-miR-15b-5p KDR 3.32329949959268 8.40210501034588e-13 -3.78753480302955 5.10405108636238e-08 miRNATAP -0.444129453078938 7.74379928112357e-08 NA NA NA hsa-miR-16-5p KDR 2.93575808220754 2.15436817162977e-10 -3.78753480302955 5.10405108636238e-08 miRTarBase;miRNATAP -0.48851016538085 4.74935391231666e-09 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-19b-1-5p KDR 1.51335451095424 0.0014717605268143 -3.78753480302955 5.10405108636238e-08 miRNAWalker2_validate -0.374119047842397 8.36263028884247e-06 NA NA NA hsa-miR-200b-3p KDR 5.56167217794639 6.43540045061709e-16 -3.78753480302955 5.10405108636238e-08 miRNAWalker2_validate;miRTarBase;TargetScan -0.288850718690057 1.3620986353193e-07 NA NA NA hsa-miR-200c-3p KDR 6.47012025883743 2.64500707716408e-26 -3.78753480302955 5.10405108636238e-08 miRNATAP -0.382297274517525 9.67613306032587e-11 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-3065-3p KDR 1.89496019576082 0.0308154823923145 -3.78753480302955 5.10405108636238e-08 miRNATAP -0.152522999657685 0.000823693140368022 NA NA NA hsa-miR-429 KDR 6.39965293994036 1.96920201593608e-18 -3.78753480302955 5.10405108636238e-08 PITA;miRanda;miRNATAP -0.254695751307412 6.75345335627532e-07 NA NA NA hsa-miR-590-3p KDR 2.35429565068338 2.79601879608564e-06 -3.78753480302955 5.10405108636238e-08 miRanda -0.291216957635586 0.000229202212262984 NA NA NA hsa-miR-590-5p KDR 1.51400888103768 0.0023888567923017 -3.78753480302955 5.10405108636238e-08 miRanda -0.22709962747644 0.00499210436033993 NA NA NA hsa-miR-590-3p KRAS 2.35429565068338 2.79601879608564e-06 0.397475629872277 0.267914845700271 PITA;miRanda;mirMAP -0.104783145997534 0.00867065435764531 NA NA NA hsa-miR-101-3p MAP2K1 -1.12421603598195 0.0200907284788457 0.519316108483181 0.113764633840027 miRNAWalker2_validate -0.210296378296097 2.59354101164885e-08 NA NA NA hsa-miR-140-3p MAP2K1 -1.9828800596692 8.92876132959514e-08 0.519316108483181 0.113764633840027 PITA -0.134317183064192 0.00692981390628658 NA NA NA hsa-miR-497-5p MAP2K1 -1.44150596209372 0.0225146607606395 0.519316108483181 0.113764633840027 miRNAWalker2_validate -0.157096186222573 4.82243556573134e-08 NA NA NA hsa-miR-148b-3p MAPK1 1.75622244535669 8.84414356040579e-08 0.0128019530419543 0.96439785606773 mirMAP -0.139901367015828 0.00442278516722453 NA NA NA hsa-miR-29b-2-5p MAPK1 -0.596051745078872 0.189540844841389 0.0128019530419543 0.96439785606773 mirMAP -0.150888486209755 2.15475742904008e-05 NA NA NA hsa-miR-29c-3p MAPK1 -0.414153610337085 0.529344128062017 0.0128019530419543 0.96439785606773 mirMAP -0.121961986993 4.61168241690927e-07 NA NA NA hsa-miR-30b-5p MAPK1 0.0238659735605804 0.953223658270319 0.0128019530419543 0.96439785606773 mirMAP -0.107494044816223 0.00753809874561411 NA NA NA hsa-miR-30e-5p MAPK1 0.780047227271616 0.0346714425913016 0.0128019530419543 0.96439785606773 mirMAP -0.116090988644527 0.00885887810727849 NA NA NA hsa-miR-3913-5p MAPK1 0.145645056779437 0.734844256690741 0.0128019530419543 0.96439785606773 mirMAP -0.108088444698366 0.00439552964093496 NA NA NA hsa-miR-324-3p MAPKAPK2 1.51345381556672 0.0038447546677657 0.0409801815001938 0.887998782758208 MirTarget -0.118424823700863 0.000138449265259097 NA NA NA hsa-miR-148b-5p NFAT5 2.80812018666078 3.97536665756679e-08 -0.873812260090285 0.0142802458392285 MirTarget -0.100855866248161 0.00959701643950966 NA NA NA hsa-miR-15b-3p NFAT5 3.57530146629867 5.89922785773482e-11 -0.873812260090285 0.0142802458392285 mirMAP -0.126013171880713 0.000433697196258896 NA NA NA hsa-miR-16-1-3p NFAT5 2.83281226969693 7.54359864580834e-09 -0.873812260090285 0.0142802458392285 mirMAP -0.130238828931912 0.00125292308133802 NA NA NA hsa-miR-21-3p NFAT5 3.50297439576639 6.39946844099206e-10 -0.873812260090285 0.0142802458392285 MirTarget -0.118527852125061 0.000620164790667205 NA NA NA hsa-miR-25-3p NFAT5 1.12623030168869 0.00311079344417173 -0.873812260090285 0.0142802458392285 miRNATAP -0.223695548560318 2.57174109236902e-05 NA NA NA hsa-miR-27b-5p NFAT5 0.213392605793392 0.71562473353293 -0.873812260090285 0.0142802458392285 miRNATAP -0.110179611906402 0.00144077959452122 NA NA NA hsa-miR-361-3p NFAT5 0.805698609170807 0.0418491665498322 -0.873812260090285 0.0142802458392285 MirTarget;PITA;miRNATAP -0.144768979044564 0.0050756704455289 NA NA NA hsa-miR-3613-5p NFAT5 4.05007522786126 4.52786477176299e-14 -0.873812260090285 0.0142802458392285 miRNATAP -0.104413571822805 0.00388544536937255 NA NA NA hsa-miR-374a-3p NFAT5 0.465360399099794 0.305267458251279 -0.873812260090285 0.0142802458392285 mirMAP -0.129458904757358 0.00396424743551628 NA NA NA hsa-miR-16-2-3p NFATC2 3.79845098071094 1.49120139344659e-13 -0.286059700331541 0.82399568318191 mirMAP -0.505831882428398 0.000198875188682268 NA NA NA hsa-miR-182-5p NFATC2 5.86988712704738 1.22411588571584e-15 -0.286059700331541 0.82399568318191 mirMAP -0.32144165425718 0.000646026696926626 NA NA NA hsa-miR-19b-3p NFATC2 1.67581705793313 0.000858910586302716 -0.286059700331541 0.82399568318191 mirMAP -0.404387130112085 0.00521651290699105 NA NA NA hsa-miR-221-3p NFATC2 0.94082283577318 0.174749164179978 -0.286059700331541 0.82399568318191 MirTarget -0.377449174577961 0.000312614420924495 NA NA NA hsa-miR-222-3p NFATC2 1.54730827524553 0.0223014220569407 -0.286059700331541 0.82399568318191 MirTarget -0.397758818078019 0.000197967348333277 NA NA NA hsa-miR-2355-5p NFATC2 0.418226038913005 0.502149040287915 -0.286059700331541 0.82399568318191 MirTarget -0.399238734977261 0.000639415285590298 NA NA NA hsa-miR-24-3p NFATC2 1.55853749533999 0.000524726461381821 -0.286059700331541 0.82399568318191 MirTarget -0.468867821397621 0.00386071331628823 NA NA NA hsa-miR-26b-3p NFATC2 0.985177548213122 0.0351427970185971 -0.286059700331541 0.82399568318191 MirTarget -0.424161999476118 0.00685427841775268 NA NA NA hsa-miR-27b-5p NFATC2 0.213392605793392 0.71562473353293 -0.286059700331541 0.82399568318191 mirMAP -0.562887952208124 5.3203758057189e-06 NA NA NA hsa-miR-30b-5p NFATC2 0.0238659735605804 0.953223658270319 -0.286059700331541 0.82399568318191 MirTarget;mirMAP -0.701664889521975 0.000103150761633541 NA NA NA hsa-miR-335-3p NFATC2 1.19503568251824 0.0938852560631551 -0.286059700331541 0.82399568318191 mirMAP -0.275457201424799 0.00698833780307122 NA NA NA hsa-miR-33a-3p NFATC2 2.06269680799532 0.00156436055383943 -0.286059700331541 0.82399568318191 mirMAP -0.49218710815049 8.56348757093332e-06 NA NA NA hsa-miR-3607-3p NFATC2 1.38015131722213 0.0240067155694847 -0.286059700331541 0.82399568318191 MirTarget;mirMAP -0.391336207534776 0.000990733127382603 NA NA NA hsa-miR-590-3p NFATC2 2.35429565068338 2.79601879608564e-06 -0.286059700331541 0.82399568318191 mirMAP -0.384051398639096 0.00750996376662493 NA NA NA hsa-miR-9-5p NFATC2 1.79620806707734 0.14526963042518 -0.286059700331541 0.82399568318191 MirTarget -0.179640503569894 0.00223258011764884 NA NA NA hsa-miR-29a-3p NFATC3 -0.638239697975974 0.251923581881716 0.477055216934867 0.106796631983734 MirTarget;miRNATAP -0.140468120986745 2.25586419429949e-06 NA NA NA hsa-miR-30a-5p NFATC3 -0.768430903969183 0.320487552854215 0.477055216934867 0.106796631983734 MirTarget;miRNATAP -0.10800426830215 3.64017456454683e-07 NA NA NA hsa-miR-505-3p NFATC3 0.58881333170866 0.226937454637888 0.477055216934867 0.106796631983734 mirMAP -0.101422391581702 0.00323042227101925 NA NA NA hsa-miR-15b-3p NFATC4 3.57530146629867 5.89922785773482e-11 -3.51227827619475 3.3529829198664e-05 mirMAP -0.332671458598109 0.000109614721294728 NA NA NA hsa-miR-193a-3p NFATC4 0.646392169474854 0.207134343676122 -3.51227827619475 3.3529829198664e-05 miRanda -0.331963642605815 0.000483436127300785 NA NA NA hsa-miR-2355-5p NFATC4 0.418226038913005 0.502149040287915 -3.51227827619475 3.3529829198664e-05 MirTarget -0.222270601628068 0.00449762571989068 NA NA NA hsa-miR-29b-3p NFATC4 0.666547117072858 0.234055379278093 -3.51227827619475 3.3529829198664e-05 miRNATAP -0.269565814376398 0.0019545991736415 NA NA NA hsa-miR-484 NFATC4 1.79050445056016 0.000217287101253701 -3.51227827619475 3.3529829198664e-05 MirTarget;miRNATAP -0.333356851887072 0.000848337680097208 NA NA NA hsa-miR-629-3p NFATC4 3.48282157979573 4.9176538695908e-08 -3.51227827619475 3.3529829198664e-05 mirMAP -0.452159715701377 5.06669620050464e-10 NA NA NA hsa-miR-429 NOS3 6.39965293994036 1.96920201593608e-18 -3.30827050659288 3.0952635386158e-07 miRanda -0.182524428897628 0.000139300055725838 NA NA NA hsa-miR-26a-5p NRAS -0.352368463397074 0.362040749917446 1.25753065997981 5.62664778753041e-06 mirMAP;miRNATAP -0.172024479324 3.07852593374564e-05 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-28-5p NRAS -0.815636722979196 0.0221199948901761 1.25753065997981 5.62664778753041e-06 MirTarget;PITA;miRanda;miRNATAP -0.124303692945862 0.00588536888643892 NA NA NA hsa-miR-29c-3p NRAS -0.414153610337085 0.529344128062017 1.25753065997981 5.62664778753041e-06 miRNATAP -0.10862780456693 5.17574009803184e-06 NA NA NA hsa-miR-148b-3p PIK3CA 1.75622244535669 8.84414356040579e-08 0.514328426212782 0.248930105421785 miRNAWalker2_validate -0.244141801200414 0.00147579635788138 NA NA NA hsa-miR-186-5p PIK3CA 0.445443449112564 0.185447310527704 0.514328426212782 0.248930105421785 mirMAP -0.280960133798979 0.000232701716483115 NA NA NA hsa-miR-29b-1-5p PIK3CA 0.33698032160171 0.598092174563471 0.514328426212782 0.248930105421785 mirMAP -0.12089066483943 0.00233700941849917 NA NA NA hsa-miR-320b PIK3CA 0.20205459771295 0.727216419960509 0.514328426212782 0.248930105421785 miRanda -0.121444800770151 0.00550932456475504 NA NA NA hsa-miR-335-5p PIK3CA 0.167216045757305 0.803897055331049 0.514328426212782 0.248930105421785 miRNAWalker2_validate -0.124494566731403 0.000883627732385134 NA NA NA hsa-miR-338-5p PIK3CA -0.108304629897487 0.894675560494607 0.514328426212782 0.248930105421785 mirMAP -0.108048495334147 0.00046563589386498 NA NA NA hsa-miR-339-5p PIK3CA 1.23326828594484 0.0307501214818698 0.514328426212782 0.248930105421785 miRanda -0.13798173006655 0.00178425799549926 NA NA NA hsa-miR-501-5p PIK3CA 1.0411896821345 0.0777206709183552 0.514328426212782 0.248930105421785 mirMAP -0.120904681333791 0.00473986403400753 NA NA NA hsa-miR-130a-3p PIK3CB 0.176861046122832 0.7577473016872 0.897158330473952 0.0125840363244796 miRNATAP -0.116582529549782 0.00106378240800672 NA NA NA hsa-miR-19b-3p PIK3CB 1.67581705793313 0.000858910586302716 0.897158330473952 0.0125840363244796 miRNATAP -0.110401307134748 0.00639042894521705 NA NA NA hsa-miR-1468-5p PIK3CD -1.63442718498426 0.00779372976116312 0.0551399776366237 0.926564879247674 MirTarget -0.153354934509346 0.00559561965869134 NA NA NA hsa-miR-199a-5p PIK3CD -1.24888110793613 0.0747755616523728 0.0551399776366237 0.926564879247674 MirTarget;PITA;miRanda;miRNATAP -0.160352223725155 0.000860262558034989 NA NA NA hsa-miR-30d-5p PIK3CD 0.302504510257496 0.380193536606962 0.0551399776366237 0.926564879247674 MirTarget;miRNATAP -0.269704587228763 0.00722775970426478 NA NA NA hsa-miR-3913-5p PIK3CD 0.145645056779437 0.734844256690741 0.0551399776366237 0.926564879247674 mirMAP -0.258109601835399 0.00117084989668902 NA NA NA hsa-miR-335-3p PIK3CG 1.19503568251824 0.0938852560631551 -0.156343505309127 0.848670326900117 mirMAP -0.289128547018831 6.98940085423769e-06 NA NA NA hsa-miR-16-2-3p PIK3R1 3.79845098071094 1.49120139344659e-13 -1.85375256159008 0.0127438113463991 MirTarget -0.220421111740374 0.0054973163518176 NA NA NA hsa-miR-16-5p PIK3R1 2.93575808220754 2.15436817162977e-10 -1.85375256159008 0.0127438113463991 MirTarget -0.232718839097215 0.0094069232214411 NA NA NA hsa-miR-17-5p PIK3R1 2.3269271449522 2.13987445663942e-05 -1.85375256159008 0.0127438113463991 MirTarget;TargetScan;miRNATAP -0.263550021803503 0.000561403048031031 NA NA NA hsa-miR-200c-3p PIK3R1 6.47012025883743 2.64500707716408e-26 -1.85375256159008 0.0127438113463991 mirMAP -0.209884750055895 0.000971059963262446 NA NA NA hsa-miR-29b-3p PIK3R1 0.666547117072858 0.234055379278093 -1.85375256159008 0.0127438113463991 MirTarget;miRNATAP -0.229458801110313 0.00247922380727846 NA NA NA hsa-miR-3065-5p PIK3R1 2.14185373842821 0.0609400502269891 -1.85375256159008 0.0127438113463991 MirTarget;mirMAP;miRNATAP -0.136442762182432 0.00300321263691178 NA NA NA hsa-miR-320c PIK3R1 -0.10618808730545 0.854002814666472 -1.85375256159008 0.0127438113463991 miRNATAP -0.237528056213487 0.00153215444016214 NA NA NA hsa-miR-330-3p PIK3R1 2.49094236945806 0.000129367003214715 -1.85375256159008 0.0127438113463991 MirTarget;PITA;miRNATAP -0.222421511130143 0.000560333266659095 NA NA NA hsa-miR-335-3p PIK3R1 1.19503568251824 0.0938852560631551 -1.85375256159008 0.0127438113463991 mirMAP -0.187424798668302 0.00154671007013318 NA NA NA hsa-miR-338-5p PIK3R1 -0.108304629897487 0.894675560494607 -1.85375256159008 0.0127438113463991 PITA -0.149038254580324 0.00415133065382571 NA NA NA hsa-miR-582-5p PIK3R1 0.685177900016753 0.447761540297692 -1.85375256159008 0.0127438113463991 mirMAP -0.168928206892885 0.000293205730117536 NA NA NA hsa-miR-584-5p PIK3R1 1.17912816682866 0.202862496863776 -1.85375256159008 0.0127438113463991 mirMAP -0.264485629334745 3.0909574049315e-09 NA NA NA hsa-miR-590-5p PIK3R1 1.51400888103768 0.0023888567923017 -1.85375256159008 0.0127438113463991 MirTarget;PITA;miRanda;miRNATAP -0.297003967343676 0.000452335914243657 NA NA NA hsa-miR-629-3p PIK3R1 3.48282157979573 4.9176538695908e-08 -1.85375256159008 0.0127438113463991 MirTarget -0.21216292379107 0.00105654186835094 NA NA NA hsa-miR-1271-5p PIK3R3 0.212382644103427 0.742544160267329 -0.029728653396571 0.959330193755408 mirMAP -0.151933011438603 0.00299533512999816 NA NA NA hsa-miR-18a-3p PIK3R3 3.64944956993027 7.20156641833731e-07 -0.029728653396571 0.959330193755408 miRNAWalker2_validate -0.172437749406846 8.76134189601592e-05 NA NA NA hsa-miR-222-5p PIK3R3 2.52056758362407 0.00142010793166944 -0.029728653396571 0.959330193755408 mirMAP -0.169591357898129 3.80520658072856e-05 NA NA NA hsa-miR-29b-1-5p PIK3R3 0.33698032160171 0.598092174563471 -0.029728653396571 0.959330193755408 mirMAP -0.214703534793861 3.15537480066889e-05 NA NA NA hsa-miR-330-3p PIK3R3 2.49094236945806 0.000129367003214715 -0.029728653396571 0.959330193755408 MirTarget -0.191183653307302 0.000135580399986553 NA NA NA hsa-miR-330-5p PIK3R3 2.25110496739954 0.000275527655397415 -0.029728653396571 0.959330193755408 miRanda -0.158989578902319 0.00262587059425892 NA NA NA hsa-miR-365a-3p PIK3R3 0.25545896241765 0.654320504621012 -0.029728653396571 0.959330193755408 MirTarget -0.330277583325266 6.38384266733533e-09 NA NA NA hsa-miR-511-5p PIK3R3 1.10428503984162 0.179276103915417 -0.029728653396571 0.959330193755408 MirTarget -0.179185145111208 6.38466351145281e-06 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-590-5p PIK3R3 1.51400888103768 0.0023888567923017 -0.029728653396571 0.959330193755408 miRanda -0.195493025557274 0.00311783468590026 NA NA NA hsa-miR-125a-3p PIK3R5 -0.0748960586927341 0.920735897434087 0.75811064163987 0.286920846128457 miRanda -0.143772140191083 0.00747323319002246 NA NA NA hsa-miR-125a-5p PIK3R5 -1.32352790615388 0.00714301627309467 0.75811064163987 0.286920846128457 MirTarget;miRanda -0.250957855170204 0.00223286885929377 NA NA NA hsa-miR-182-5p PIK3R5 5.86988712704738 1.22411588571584e-15 0.75811064163987 0.286920846128457 MirTarget -0.25329203027594 9.2894340160784e-07 NA NA NA hsa-miR-142-3p PLA2G12A 4.35304505457969 3.10014573651358e-10 -0.348931284411703 0.228360506827383 miRanda -0.10322065696675 5.11675789428433e-06 NA NA NA hsa-miR-142-5p PLA2G12A 3.95552531913424 1.49536283724079e-08 -0.348931284411703 0.228360506827383 mirMAP -0.125434802427425 1.99725477945959e-08 NA NA NA hsa-miR-491-5p PLA2G2A 0.569358547192776 0.313310594748302 -3.35004246895337 0.0852880829350494 miRanda -0.56271081292586 0.00482974128542031 NA NA NA hsa-miR-125a-5p PLA2G2F -1.32352790615388 0.00714301627309467 4.61318022259117 0.0169435167136214 mirMAP -1.06452110955483 1.51556404188548e-06 NA NA NA hsa-miR-125b-5p PLA2G2F -2.01187572101832 0.00516480893645494 4.61318022259117 0.0169435167136214 mirMAP -0.40347317100202 0.00803625949584725 NA NA NA hsa-miR-324-3p PLA2G2F 1.51345381556672 0.0038447546677657 4.61318022259117 0.0169435167136214 mirMAP -0.655625739442234 0.00177309107493498 NA NA NA hsa-miR-335-5p PLA2G2F 0.167216045757305 0.803897055331049 4.61318022259117 0.0169435167136214 mirMAP -0.470559276052835 0.00402796787980824 NA NA NA hsa-let-7e-5p PLA2G3 -0.111012524740586 0.814744515884005 5.30782171549448 0.00470136493378772 MirTarget -0.83647950156538 0.000230679406013596 NA NA NA hsa-miR-125a-3p PLA2G3 -0.0748960586927341 0.920735897434087 5.30782171549448 0.00470136493378772 miRanda;miRNATAP -0.512587256488481 0.00030751805191174 NA NA NA hsa-miR-32-3p PLA2G3 2.20477794939766 0.0392771274032852 5.30782171549448 0.00470136493378772 miRNATAP -0.599678039838321 0.000646345923075148 NA NA NA hsa-miR-590-3p PLA2G4A 2.35429565068338 2.79601879608564e-06 -1.18655189146257 0.318420995084282 miRanda -0.356477543361995 0.00732189671160126 NA NA NA hsa-miR-2355-3p PLA2G6 0.494099635633886 0.483724014019781 0.0372700921853339 0.944252191933756 MirTarget -0.224599201216566 9.75788647461578e-08 NA NA NA hsa-miR-125a-5p PLCG2 -1.32352790615388 0.00714301627309467 -1.08906385004625 0.0543758329029676 miRanda -0.181363136290711 0.00558328446420801 NA NA NA hsa-miR-335-5p PLCG2 0.167216045757305 0.803897055331049 -1.08906385004625 0.0543758329029676 miRNAWalker2_validate -0.198803359537002 2.75411678498945e-05 NA NA NA hsa-let-7g-5p PPP3CA 0.857251702023746 0.00647597344297273 -0.0994691469518081 0.767527156115313 miRNATAP -0.161347150543761 0.00879795113322894 NA NA NA hsa-miR-142-5p PRKCA 3.95552531913424 1.49536283724079e-08 -2.51484065178579 0.000301846026330391 mirMAP -0.157985182568495 0.00450284307697346 NA NA NA hsa-miR-183-5p PRKCA 6.61903249270777 1.00958881445636e-16 -2.51484065178579 0.000301846026330391 miRNATAP -0.195964689338451 2.96312561009603e-05 NA NA NA hsa-miR-200c-3p PRKCA 6.47012025883743 2.64500707716408e-26 -2.51484065178579 0.000301846026330391 miRNATAP -0.227644911192639 0.000134967313056447 NA NA NA hsa-miR-30e-3p PRKCA -0.0362193022195196 0.932577027239525 -2.51484065178579 0.000301846026330391 mirMAP -0.330264937460595 0.000431865199778726 NA NA NA hsa-miR-330-3p PRKCA 2.49094236945806 0.000129367003214715 -2.51484065178579 0.000301846026330391 mirMAP -0.173880498227238 0.0042321147753766 NA NA NA hsa-miR-340-5p PRKCA 1.41210478721579 0.00958612942879818 -2.51484065178579 0.000301846026330391 mirMAP -0.247780249808726 0.000683356782218492 NA NA NA hsa-miR-374a-3p PRKCA 0.465360399099794 0.305267458251279 -2.51484065178579 0.000301846026330391 mirMAP -0.324087022951615 0.000236966482552477 NA NA NA hsa-miR-374a-5p PRKCA 0.278549982012055 0.45888283715888 -2.51484065178579 0.000301846026330391 mirMAP -0.315860192203564 0.00334938709870334 NA NA NA hsa-miR-590-3p PRKCA 2.35429565068338 2.79601879608564e-06 -2.51484065178579 0.000301846026330391 PITA;miRanda;mirMAP;miRNATAP -0.344157378397527 9.41463074505618e-06 NA NA NA hsa-miR-9-5p PRKCA 1.79620806707734 0.14526963042518 -2.51484065178579 0.000301846026330391 miRNATAP -0.102263861653536 0.00143068318206041 NA NA NA hsa-miR-944 PRKCA 7.20925181386398 0.000823207457340648 -2.51484065178579 0.000301846026330391 PITA;miRNATAP -0.163061119524878 9.18211721568101e-14 NA NA NA hsa-miR-129-5p PRKCB -2.66843722411409 0.00695783358331245 -1.37779465994896 0.125783325051528 miRanda;mirMAP -0.148528580809065 0.00435751368999719 NA NA NA hsa-miR-130a-5p PRKCB 1.58028512890005 0.024346333013728 -1.37779465994896 0.125783325051528 mirMAP -0.212100504604163 0.00409650973476373 NA NA NA hsa-miR-141-5p PRKCB 7.13744624551943 4.06877058732583e-26 -1.37779465994896 0.125783325051528 mirMAP -0.19239678572128 0.00558256661173632 NA NA NA hsa-miR-200b-3p PRKCB 5.56167217794639 6.43540045061709e-16 -1.37779465994896 0.125783325051528 MirTarget -0.301150868895001 1.67192981795653e-05 NA NA NA hsa-miR-200c-3p PRKCB 6.47012025883743 2.64500707716408e-26 -1.37779465994896 0.125783325051528 MirTarget;miRNATAP -0.348745791831867 4.59454351785762e-06 NA NA NA hsa-miR-24-3p PRKCB 1.55853749533999 0.000524726461381821 -1.37779465994896 0.125783325051528 miRNATAP -0.348466036252195 0.00216084517312112 NA NA NA hsa-miR-30d-3p PRKCB -0.0740421896025512 0.857423650167556 -1.37779465994896 0.125783325051528 mirMAP -0.466704414757516 0.000189785701017437 NA NA NA hsa-miR-335-3p PRKCB 1.19503568251824 0.0938852560631551 -1.37779465994896 0.125783325051528 mirMAP -0.319943845988664 6.21148850866805e-06 NA NA NA hsa-miR-335-5p PRKCB 0.167216045757305 0.803897055331049 -1.37779465994896 0.125783325051528 mirMAP -0.264751633170281 0.000471558920124749 NA NA NA hsa-miR-429 PRKCB 6.39965293994036 1.96920201593608e-18 -1.37779465994896 0.125783325051528 MirTarget;miRanda;miRNATAP -0.361917851736747 2.11441310702277e-08 NA NA NA hsa-miR-589-3p PRKCB 1.33205316880069 0.052632683806148 -1.37779465994896 0.125783325051528 mirMAP -0.256370688506043 0.000574321239976677 NA NA NA hsa-miR-590-5p PRKCB 1.51400888103768 0.0023888567923017 -1.37779465994896 0.125783325051528 miRanda -0.299520538968311 0.00345339662465929 NA NA NA hsa-miR-9-3p PRKCB 1.69328215716742 0.125170982657059 -1.37779465994896 0.125783325051528 mirMAP -0.175906285304137 0.000158783736278398 NA NA NA hsa-miR-146b-5p PTGS2 1.87569569182453 0.000737241069698886 0.9437178124877 0.492699616079197 miRanda -0.374908072993798 0.0073507624180067 NA NA NA hsa-miR-362-3p PTGS2 0.679952485897744 0.226148468488576 0.9437178124877 0.492699616079197 miRanda -0.457003281199269 0.0010528740508217 NA NA NA hsa-miR-576-5p PTGS2 1.30320223793746 0.00648929463912994 0.9437178124877 0.492699616079197 mirMAP -0.504007439855052 0.00200557275336394 NA NA NA hsa-miR-140-5p PTK2 -0.634610285725923 0.126670572966239 0.0169252268225506 0.955885098049357 miRanda -0.117371495238972 0.00511931286364758 NA NA NA hsa-miR-199a-5p PXN -1.24888110793613 0.0747755616523728 -0.38780560219893 0.448861558904431 MirTarget;PITA;miRNATAP -0.150509082089268 0.000250034724760351 NA NA NA hsa-miR-374a-5p RAC1 0.278549982012055 0.45888283715888 0.0440982372971011 0.900045954349393 mirMAP -0.140356402054542 0.00882655342567711 NA NA NA hsa-miR-450b-5p RAC1 0.445103105471153 0.416021465008949 0.0440982372971011 0.900045954349393 mirMAP -0.108599310907085 0.00278942668689792 NA NA NA hsa-miR-129-5p RAC2 -2.66843722411409 0.00695783358331245 1.63571810371488 0.0215946836435966 miRanda -0.123304880787715 0.00280670600839041 NA NA NA hsa-miR-497-5p SH2D2A -1.44150596209372 0.0225146607606395 2.07353896447117 0.00515728323629303 MirTarget -0.210878545888437 0.00155824034056355 NA NA NA hsa-miR-130b-5p SRC 3.74118449312296 2.92266550966038e-10 0.102375024620883 0.79702294660252 mirMAP -0.106121855504391 0.00392356399351017 NA NA NA hsa-miR-15b-5p SRC 3.32329949959268 8.40210501034588e-13 0.102375024620883 0.79702294660252 mirMAP -0.127054959100803 0.00672196853750947 NA NA NA hsa-miR-181a-2-3p SRC 0.892907671722579 0.191670574975465 0.102375024620883 0.79702294660252 mirMAP -0.112124525217707 0.000621224990160472 NA NA NA hsa-miR-181c-3p SRC 0.451537053043082 0.423921169558333 0.102375024620883 0.79702294660252 mirMAP -0.140116596521663 0.000433708221629455 NA NA NA hsa-miR-182-5p SRC 5.86988712704738 1.22411588571584e-15 0.102375024620883 0.79702294660252 mirMAP -0.139329201247741 1.2776644599108e-06 NA NA NA hsa-miR-197-3p SRC 1.23723883665376 0.0073292027020411 0.102375024620883 0.79702294660252 mirMAP -0.162115355099307 0.000887347841140264 NA NA NA hsa-miR-20a-3p SRC 1.9920766549842 0.000624458530894697 0.102375024620883 0.79702294660252 mirMAP -0.155200005550944 4.66112366915258e-05 NA NA NA hsa-miR-301a-3p SRC 1.99338115332667 0.000813358604963724 0.102375024620883 0.79702294660252 mirMAP -0.102506300028898 0.00634715235809097 NA NA NA hsa-miR-331-3p SRC 2.60769294751513 3.84318952029483e-07 0.102375024620883 0.79702294660252 MirTarget -0.11670992676258 0.0068438970051965 NA NA NA hsa-miR-96-5p SRC 5.62521466029286 1.54938806718028e-10 0.102375024620883 0.79702294660252 mirMAP -0.14692012512374 9.19742305880954e-07 NA NA NA hsa-miR-101-3p VEGFA -1.12421603598195 0.0200907284788457 -0.606702191559893 0.316325541201332 miRNAWalker2_validate -0.44049017437003 2.14988554587478e-10 NA NA NA hsa-miR-140-5p VEGFA -0.634610285725923 0.126670572966239 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.25107167892515 0.00261330338296037 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-145-5p VEGFA -3.55505374822025 5.45525288912869e-07 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase -0.128423755259373 0.00677881518234136 24781864;24966896;22472569 Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically metastasis;; thyroid cancer;bladder cancer;sarcoma hsa-miR-150-5p VEGFA 1.76769157530064 0.0593795975117846 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase -0.190454559321715 1.05415152205695e-07 NA NA NA hsa-miR-195-5p VEGFA -1.59182537400701 0.0169128463756769 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase;MirTarget -0.181624543409355 0.000381561947949573 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA -1.24888110793613 0.0747755616523728 -0.606702191559893 0.316325541201332 miRanda;miRNATAP -0.137846678781097 0.00478526288616186 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA -0.53728867775768 0.476885702455766 -0.606702191559893 0.316325541201332 miRanda -0.179432408970336 6.95568617152433e-05 NA NA NA hsa-miR-29a-3p VEGFA -0.638239697975974 0.251923581881716 -0.606702191559893 0.316325541201332 MirTarget -0.17079026405468 0.00573296636369365 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29b-2-5p VEGFA -0.596051745078872 0.189540844841389 -0.606702191559893 0.316325541201332 MirTarget -0.280821422267245 0.000211600516233879 NA NA NA hsa-miR-29b-3p VEGFA 0.666547117072858 0.234055379278093 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;miRTarBase;MirTarget -0.16053544503029 0.00905921871447091 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-29c-3p VEGFA -0.414153610337085 0.529344128062017 -0.606702191559893 0.316325541201332 miRNAWalker2_validate;MirTarget -0.264648504422189 2.62132710063096e-07 NA NA NA hsa-miR-342-3p VEGFA 1.31107714473009 0.0207211910724662 -0.606702191559893 0.316325541201332 miRanda;miRNATAP -0.189890193502324 0.00167517321250592 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-497-5p VEGFA -1.44150596209372 0.0225146607606395 -0.606702191559893 0.316325541201332 MirTarget -0.20501977308518 0.000143045715274148 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer