miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-28-5p AAAS -0.14267073663385 0.0497619246260571 0.333961696450526 1.76247956290803e-10 miRNAWalker2_validate -0.192144123006222 8.0625876745442e-15 NA NA NA hsa-miR-28-5p AAGAB -0.14267073663385 0.0497619246260571 0.814198545635563 5.08425148014984e-36 miRanda -0.261414067779177 1.78986406092867e-16 NA NA NA hsa-miR-28-5p AATK -0.14267073663385 0.0497619246260571 0.453430702519743 0.00408123503396711 miRanda -0.27417826152726 0.000266548654540702 NA NA NA hsa-miR-200a-3p ABCA1 2.55218480823434 2.96135446816238e-51 -1.41003867527676 8.01229714514919e-38 mirMAP -0.253171097399316 2.80423350246485e-33 NA NA NA hsa-miR-200b-3p ABCA1 2.11744072703209 1.66710572104191e-43 -1.41003867527676 8.01229714514919e-38 TargetScan -0.283811342028782 7.93574234190737e-34 NA NA NA hsa-miR-200b-3p ABCA10 2.11744072703209 1.66710572104191e-43 -4.62619452417002 7.14146439742034e-87 mirMAP -0.53591695349654 3.28726725718492e-23 NA NA NA hsa-miR-28-5p ABCB9 -0.14267073663385 0.0497619246260571 0.947933279325208 1.1543853299555e-17 miRanda -0.262888980111223 9.28660818341309e-07 NA NA NA hsa-miR-132-3p ABCC5 -0.0365213889238607 0.668598301088667 0.797302989981293 1.93030507748535e-11 mirMAP -0.160222142379867 0.000989719530740983 NA NA NA hsa-miR-28-5p ABCC5 -0.14267073663385 0.0497619246260571 0.797302989981293 1.93030507748535e-11 miRanda;mirMAP -0.158910926194168 0.00553032764471306 NA NA NA hsa-miR-132-3p ABCG1 -0.0365213889238607 0.668598301088667 0.659203954025358 2.25107654014081e-09 MirTarget -0.240653294015369 7.7192398603196e-08 NA NA NA hsa-miR-28-5p ABHD1 -0.14267073663385 0.0497619246260571 -0.979242702067246 7.11422819612358e-10 miRanda -0.304354305354412 6.60803787379825e-05 NA NA NA hsa-miR-28-5p ABHD2 -0.14267073663385 0.0497619246260571 0.450213534981843 0.000527417369441251 mirMAP -0.249741823196824 5.41341783770208e-05 NA NA NA hsa-miR-28-5p ABLIM3 -0.14267073663385 0.0497619246260571 -1.87900809021962 1.5479100001313e-23 miRanda -0.636062725407327 2.75091626853684e-12 NA NA NA hsa-miR-28-5p ACACA -0.14267073663385 0.0497619246260571 -0.221648651129382 0.021619749795881 miRanda -0.161588815074034 0.00043088920351934 NA NA NA hsa-miR-28-5p ACAD8 -0.14267073663385 0.0497619246260571 -0.35954398205226 2.03716487332537e-07 miRanda -0.124555556230843 0.000165960983426681 NA NA NA hsa-miR-28-5p ACAT1 -0.14267073663385 0.0497619246260571 -0.751385545284676 2.05460285005042e-17 miRanda -0.156118622908354 0.000274432130308958 NA NA NA hsa-miR-28-5p ACE -0.14267073663385 0.0497619246260571 -0.332940992836159 0.00163444230017096 mirMAP -0.116898229723062 0.0205352786077771 NA NA NA hsa-miR-200b-3p ACE2 2.11744072703209 1.66710572104191e-43 -2.44666505291094 5.7620122495315e-15 TargetScan -0.306113069761062 5.51887722129256e-06 NA NA NA hsa-miR-200c-3p ACE2 2.07038651806183 6.84613386286599e-51 -2.44666505291094 5.7620122495315e-15 miRNATAP -0.318325398623016 1.75220441613177e-05 NA NA NA hsa-miR-141-3p ACO1 2.99777540204168 1.26370498493024e-78 -1.62951665297927 9.7988966479822e-70 MirTarget;TargetScan -0.319542842463036 4.31583453848052e-71 NA NA NA hsa-miR-200a-3p ACO1 2.55218480823434 2.96135446816238e-51 -1.62951665297927 9.7988966479822e-70 MirTarget -0.256023074843234 5.21297435377469e-45 NA NA NA hsa-miR-28-5p ACOX3 -0.14267073663385 0.0497619246260571 0.203718310604422 0.0232698998426671 miRanda -0.184836000309236 1.4443916193675e-05 NA NA NA hsa-miR-28-5p ACSF2 -0.14267073663385 0.0497619246260571 -0.25646487247878 0.0548866843292958 miRanda -0.311846743736682 8.46857904574377e-07 NA NA NA hsa-miR-200b-3p ACTC1 2.11744072703209 1.66710572104191e-43 -1.24903172217607 7.23611450835938e-07 MirTarget -0.358826299549212 1.57598939825919e-11 NA NA NA hsa-miR-200c-3p ACTC1 2.07038651806183 6.84613386286599e-51 -1.24903172217607 7.23611450835938e-07 MirTarget -0.450845796805972 1.03869011105321e-14 NA NA NA hsa-miR-145-5p ACTG1 -2.62703571936687 7.64402900188551e-88 0.705064523343649 4.55348682247055e-34 MirTarget;miRNATAP -0.120992999299289 1.16347849721028e-18 NA NA NA hsa-let-7e-5p ACVR1C 0.261471269338985 0.00191077095550257 -5.20071129736289 8.81931099882978e-104 MirTarget;miRNATAP -0.391129535622582 0.000478036013006995 NA NA NA hsa-miR-200b-3p ACVR1C 2.11744072703209 1.66710572104191e-43 -5.20071129736289 8.81931099882978e-104 TargetScan -0.692003711219126 2.03439748086501e-35 NA NA NA hsa-let-7e-5p ACVR2A 0.261471269338985 0.00191077095550257 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.110838593636447 0.000569208718270341 NA NA NA hsa-miR-141-3p ACVR2A 2.99777540204168 1.26370498493024e-78 -0.964184609321378 1.30052843588401e-37 TargetScan;miRNATAP -0.161379309311092 1.25725298325859e-27 NA NA NA hsa-miR-200a-3p ACVR2A 2.55218480823434 2.96135446816238e-51 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.142523834102645 2.08957993508987e-22 NA NA NA hsa-miR-200b-3p ACVR2A 2.11744072703209 1.66710572104191e-43 -0.964184609321378 1.30052843588401e-37 TargetScan -0.143541862814667 1.76104677420962e-18 NA NA NA hsa-miR-200c-3p ACVR2A 2.07038651806183 6.84613386286599e-51 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.155691181802949 5.31342226529533e-18 NA NA NA hsa-miR-145-5p ADAM19 -2.62703571936687 7.64402900188551e-88 1.59762293716606 1.34099246856257e-33 MirTarget;miRNATAP -0.150066364021448 2.52510427961121e-06 26823772 MiR 145 suppressed human retinoblastoma cell proliferation and invasion by targeting ADAM19; ADAM19 was identified as a direct target of miR-145; In addition a reverse correlation between miR-145 and ADAM19 expression was noted in RB tissues retinoblastoma hsa-miR-141-3p ADAM22 2.99777540204168 1.26370498493024e-78 -1.22400577928345 9.86358971049703e-10 MirTarget -0.325602841119381 3.36084407370533e-17 NA NA NA hsa-miR-200a-3p ADAM22 2.55218480823434 2.96135446816238e-51 -1.22400577928345 9.86358971049703e-10 MirTarget -0.323271972498928 1.35746751762615e-17 NA NA NA hsa-miR-200b-3p ADAMTS12 2.11744072703209 1.66710572104191e-43 0.095778097632242 0.620632223066072 mirMAP -0.264667258652387 7.10484765340681e-11 NA NA NA hsa-miR-28-5p ADAMTS13 -0.14267073663385 0.0497619246260571 0.49002440332112 0.000583985090350807 miRanda -0.252476874446622 0.000201582106068662 NA NA NA hsa-miR-28-5p ADAMTS15 -0.14267073663385 0.0497619246260571 -0.937301278982712 0.000986418612067539 mirMAP -1.13257971395055 1.99302439160863e-17 NA NA NA hsa-miR-200b-3p ADAMTS3 2.11744072703209 1.66710572104191e-43 -1.84542990234679 6.7161576251528e-32 TargetScan -0.357854787678135 1.65460196696587e-26 NA NA NA hsa-miR-200c-3p ADAMTS3 2.07038651806183 6.84613386286599e-51 -1.84542990234679 6.7161576251528e-32 miRNATAP -0.378913133197869 1.40447480810563e-24 NA NA NA hsa-let-7e-5p ADAMTS5 0.261471269338985 0.00191077095550257 -3.55145538959317 1.2022506062627e-103 miRNATAP -0.267849269900664 0.000462584381448905 NA NA NA hsa-miR-200b-3p ADAMTS5 2.11744072703209 1.66710572104191e-43 -3.55145538959317 1.2022506062627e-103 mirMAP -0.536814433225817 1.92001467155117e-46 NA NA NA hsa-miR-132-3p ADAMTS6 -0.0365213889238607 0.668598301088667 1.10058301750212 2.21011245527404e-16 miRNATAP -0.16661636325868 0.0025832335892907 NA NA NA hsa-let-7e-5p ADAMTS8 0.261471269338985 0.00191077095550257 -1.48496240125896 1.48763928317619e-10 MirTarget;miRNATAP -0.300146457794692 0.00173873432785321 NA NA NA hsa-miR-141-3p ADARB1 2.99777540204168 1.26370498493024e-78 -0.595462613403038 1.3979457164121e-17 MirTarget -0.12740702253446 3.6563894379826e-21 NA NA NA hsa-miR-200a-3p ADARB1 2.55218480823434 2.96135446816238e-51 -0.595462613403038 1.3979457164121e-17 MirTarget -0.113567939072377 1.36497140977077e-17 NA NA NA hsa-miR-28-5p ADCK1 -0.14267073663385 0.0497619246260571 0.187517081387471 0.00450919989695981 miRanda -0.120939647200665 0.000115520676281999 NA NA NA hsa-miR-28-5p ADCY1 -0.14267073663385 0.0497619246260571 -0.0486801025784516 0.841490665662841 miRanda -0.592080609407235 2.7807221777423e-07 NA NA NA hsa-miR-200b-3p ADCY2 2.11744072703209 1.66710572104191e-43 -0.730984831999796 0.00385028718944911 MirTarget;TargetScan -0.158301628874175 0.00321935577020458 NA NA NA hsa-miR-200c-3p ADCY2 2.07038651806183 6.84613386286599e-51 -0.730984831999796 0.00385028718944911 MirTarget;miRNATAP -0.244459398144202 3.36053103479726e-05 NA NA NA hsa-miR-28-5p ADCY6 -0.14267073663385 0.0497619246260571 -0.631200513666625 6.14065292828624e-14 miRanda -0.322887202501352 6.58653319288642e-16 NA NA NA hsa-miR-28-5p ADCY9 -0.14267073663385 0.0497619246260571 0.119176736188088 0.238393404822703 mirMAP -0.404281115591368 1.04288894285062e-17 NA NA NA hsa-miR-141-3p ADD3 2.99777540204168 1.26370498493024e-78 -1.65685209718137 2.45003179969732e-41 TargetScan -0.263212960545939 3.81687617104989e-27 NA NA NA hsa-miR-200b-3p ADD3 2.11744072703209 1.66710572104191e-43 -1.65685209718137 2.45003179969732e-41 MirTarget;TargetScan -0.266738935573403 2.02311152238729e-23 NA NA NA hsa-miR-200c-3p ADD3 2.07038651806183 6.84613386286599e-51 -1.65685209718137 2.45003179969732e-41 MirTarget -0.256701147005047 4.49797313975644e-18 NA NA NA hsa-miR-145-5p ADM2 -2.62703571936687 7.64402900188551e-88 2.40773160906737 2.14684505542733e-54 mirMAP -0.434764452239048 1.22178026224893e-31 NA NA NA hsa-miR-141-3p ADRB1 2.99777540204168 1.26370498493024e-78 -2.83309870348525 5.19354788418045e-26 TargetScan -0.472920237063766 3.18772778571292e-19 NA NA NA hsa-let-7e-5p ADRB2 0.261471269338985 0.00191077095550257 -3.09389503467424 5.97144378681382e-78 MirTarget -0.362038571592629 1.13707765052099e-06 NA NA NA hsa-miR-132-3p AFF1 -0.0365213889238607 0.668598301088667 -0.822613403095266 3.54527732954134e-21 mirMAP -0.141664139682236 8.52902204346657e-05 NA NA NA hsa-miR-141-3p AFF1 2.99777540204168 1.26370498493024e-78 -0.822613403095266 3.54527732954134e-21 TargetScan -0.167728319342324 3.09578103922853e-23 NA NA NA hsa-miR-200b-3p AFF1 2.11744072703209 1.66710572104191e-43 -0.822613403095266 3.54527732954134e-21 TargetScan -0.146711896562333 3.4043465732044e-15 NA NA NA hsa-miR-28-5p AFF1 -0.14267073663385 0.0497619246260571 -0.822613403095266 3.54527732954134e-21 miRanda -0.181485420169248 1.84515565349079e-05 NA NA NA hsa-miR-28-5p AFF4 -0.14267073663385 0.0497619246260571 -0.281510843525455 0.00153080576834839 MirTarget;miRanda -0.198317096353644 2.59227723832472e-06 NA NA NA hsa-miR-28-5p AFTPH -0.14267073663385 0.0497619246260571 0.310042514383331 6.63540668673408e-07 miRanda -0.100572748665942 0.000737307674554123 NA NA NA hsa-miR-28-5p AGAP11 -0.14267073663385 0.0497619246260571 -2.71964004520601 8.30765328552898e-62 miRanda -0.311912698282939 0.000215531155380505 NA NA NA hsa-miR-28-5p AGBL4 -0.14267073663385 0.0497619246260571 -0.142971148431008 0.45128658353738 miRanda -0.235687807620684 0.00911628251703385 NA NA NA hsa-let-7e-5p AGMAT 0.261471269338985 0.00191077095550257 1.48756865195736 3.00482085953982e-31 miRNAWalker2_validate -0.109174829152805 0.044920987444433 NA NA NA hsa-miR-200a-3p AGPAT4 2.55218480823434 2.96135446816238e-51 -0.74402848976969 1.61331655609006e-10 mirMAP -0.178524297114093 5.75801202016347e-16 NA NA NA hsa-miR-200b-3p AHNAK 2.11744072703209 1.66710572104191e-43 -1.76535987346934 5.20116033627817e-56 TargetScan -0.263885490205761 1.22369803090683e-26 NA NA NA hsa-miR-28-5p AHNAK -0.14267073663385 0.0497619246260571 -1.76535987346934 5.20116033627817e-56 PITA;miRanda;miRNATAP -0.267450672419509 2.68436282191842e-06 NA NA NA hsa-miR-141-3p AHR 2.99777540204168 1.26370498493024e-78 -0.980545120708858 4.33733784004484e-18 MirTarget -0.159395599815798 6.33120628570809e-13 NA NA NA hsa-miR-200a-3p AHR 2.55218480823434 2.96135446816238e-51 -0.980545120708858 4.33733784004484e-18 MirTarget -0.124621123477467 1.19874035196394e-08 NA NA NA hsa-miR-145-5p AIFM1 -2.62703571936687 7.64402900188551e-88 0.674161514281666 1.79345695695194e-25 miRNATAP -0.134460530608588 6.48751185465965e-19 20332243 Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death prostate cancer hsa-miR-141-3p AKAP11 2.99777540204168 1.26370498493024e-78 -0.849803143270922 1.35049720212879e-21 MirTarget;TargetScan -0.144425538403945 1.16186013193176e-16 NA NA NA hsa-miR-200a-3p AKAP11 2.55218480823434 2.96135446816238e-51 -0.849803143270922 1.35049720212879e-21 MirTarget -0.127992419305463 8.85216219295759e-14 NA NA NA hsa-miR-200b-3p AKAP13 2.11744072703209 1.66710572104191e-43 -0.608726058300724 5.65488571630791e-18 mirMAP -0.120344712015622 9.74069500904e-16 NA NA NA hsa-miR-141-3p AKAP2 2.99777540204168 1.26370498493024e-78 -2.13773125985336 8.00531395229553e-27 TargetScan -0.428215598358269 2.06620881154245e-28 NA NA NA hsa-miR-200b-3p AKAP2 2.11744072703209 1.66710572104191e-43 -2.13773125985336 8.00531395229553e-27 TargetScan -0.405091591317364 2.18933410621375e-21 NA NA NA hsa-let-7e-5p AKAP6 0.261471269338985 0.00191077095550257 -2.28015270926059 6.96245937007291e-60 MirTarget -0.143298323065523 0.0201697469272177 NA NA NA hsa-miR-200c-3p AKAP7 2.07038651806183 6.84613386286599e-51 -1.0178339192539 7.53705785799862e-33 miRNATAP -0.190834063323771 3.5627421858081e-21 NA NA NA hsa-miR-28-5p AKR7A2 -0.14267073663385 0.0497619246260571 0.343255312465302 8.62257546469888e-06 miRanda -0.23936896990541 5.47058062758386e-11 NA NA NA hsa-miR-143-3p AKT1 -1.23248181631499 4.74160976678504e-28 0.675644771423915 4.31393881321574e-23 miRNAWalker2_validate -0.113351907486334 3.74647210660112e-08 NA NA NA hsa-miR-28-5p ALDH3A2 -0.14267073663385 0.0497619246260571 -0.860769652123822 9.84587277412076e-16 miRanda -0.292717815903004 1.40563132631418e-08 NA NA NA hsa-miR-28-5p AMIGO2 -0.14267073663385 0.0497619246260571 -1.57919489364877 1.03555350832452e-17 miRanda -0.238335214108372 0.00783964240570731 NA NA NA hsa-miR-143-3p AMMECR1 -1.23248181631499 4.74160976678504e-28 0.820552955502696 5.79082960254587e-17 miRNATAP -0.113396071441975 0.000121807033065255 NA NA NA hsa-let-7e-5p AMOT 0.261471269338985 0.00191077095550257 -0.909511733140738 9.01707191016367e-13 MirTarget -0.16314562476317 0.00199212708404097 NA NA NA hsa-miR-141-3p AMOTL1 2.99777540204168 1.26370498493024e-78 -1.81201810992899 1.05521553005433e-44 TargetScan -0.360715714538228 5.88104675427885e-47 NA NA NA hsa-miR-200b-3p AMOTL2 2.11744072703209 1.66710572104191e-43 -1.56594440622319 8.21783947483569e-62 MirTarget;TargetScan -0.197924100714029 7.66668807426866e-21 NA NA NA hsa-miR-200c-3p AMOTL2 2.07038651806183 6.84613386286599e-51 -1.56594440622319 8.21783947483569e-62 MirTarget;miRNATAP -0.28595633906363 3.76895161364983e-36 NA NA NA hsa-miR-28-5p AMPH -0.14267073663385 0.0497619246260571 -0.229137854504136 0.257667598863092 MirTarget;PITA;miRanda -0.379789131994063 7.84571508819915e-05 NA NA NA hsa-let-7e-5p AMT 0.261471269338985 0.00191077095550257 -1.26692807174467 2.4916311221105e-18 MirTarget -0.123577064469536 0.0417524936131754 NA NA NA hsa-miR-28-5p AMZ1 -0.14267073663385 0.0497619246260571 2.49247827940287 4.85570356046494e-25 miRanda -0.449900404852048 0.000141115554584685 NA NA NA hsa-miR-28-5p ANGEL1 -0.14267073663385 0.0497619246260571 -0.244973705180581 5.45027775560672e-05 miRanda -0.140734378364615 1.04645383987188e-06 NA NA NA hsa-miR-141-3p ANGPTL1 2.99777540204168 1.26370498493024e-78 -3.72061004689091 3.17960434867383e-73 MirTarget -0.825151345507015 3.21808884767287e-101 NA NA NA hsa-miR-200a-3p ANGPTL1 2.55218480823434 2.96135446816238e-51 -3.72061004689091 3.17960434867383e-73 MirTarget -0.661548060367103 5.84581781860266e-62 NA NA NA hsa-miR-141-3p ANK2 2.99777540204168 1.26370498493024e-78 -2.50568252042295 2.12750718019692e-56 TargetScan;miRNATAP -0.568863103205172 7.63797154489955e-81 NA NA NA hsa-miR-200a-3p ANK2 2.55218480823434 2.96135446816238e-51 -2.50568252042295 2.12750718019692e-56 miRNATAP -0.460747281221904 7.89543593463606e-52 NA NA NA hsa-miR-200b-3p ANKH 2.11744072703209 1.66710572104191e-43 -0.310260036945063 0.00327101824761011 TargetScan -0.126693737676158 1.22328119806009e-08 NA NA NA hsa-miR-200c-3p ANKH 2.07038651806183 6.84613386286599e-51 -0.310260036945063 0.00327101824761011 miRNATAP -0.156974091082588 1.23229484414772e-10 NA NA NA hsa-miR-141-3p ANKRD44 2.99777540204168 1.26370498493024e-78 -0.721040566621111 3.92080009780825e-06 TargetScan -0.208148414083597 5.28742641506444e-12 NA NA NA hsa-miR-28-5p ANKS1B -0.14267073663385 0.0497619246260571 0.195574172772792 0.219403504513109 miRanda -0.42370630515817 1.82751876578841e-08 NA NA NA hsa-miR-28-5p ANKS3 -0.14267073663385 0.0497619246260571 0.722561297123601 2.02940894883196e-12 miRanda -0.161675758886296 0.00110175526475344 NA NA NA hsa-miR-141-3p ANO5 2.99777540204168 1.26370498493024e-78 -1.98544340155599 8.34965716678519e-13 mirMAP -0.340657712632385 3.31467408994044e-10 NA NA NA hsa-miR-200a-3p ANO5 2.55218480823434 2.96135446816238e-51 -1.98544340155599 8.34965716678519e-13 mirMAP -0.311185295258454 5.18687155653097e-09 NA NA NA hsa-miR-200b-3p ANO5 2.11744072703209 1.66710572104191e-43 -1.98544340155599 8.34965716678519e-13 TargetScan -0.373263705818667 2.79179284186207e-10 NA NA NA hsa-miR-141-3p ANO6 2.99777540204168 1.26370498493024e-78 -1.49912453977001 1.20172073520865e-64 MirTarget;TargetScan -0.281754150820712 9.20313817915817e-60 NA NA NA hsa-miR-200a-3p ANO6 2.55218480823434 2.96135446816238e-51 -1.49912453977001 1.20172073520865e-64 MirTarget -0.258005973885225 3.45014543233283e-51 NA NA NA hsa-miR-200b-3p ANO6 2.11744072703209 1.66710572104191e-43 -1.49912453977001 1.20172073520865e-64 TargetScan -0.284382409685243 3.53581782770677e-50 NA NA NA hsa-miR-28-5p ANXA9 -0.14267073663385 0.0497619246260571 1.77703853413407 4.65169713363917e-15 miRanda -1.04785141788144 1.34518763922765e-22 NA NA NA hsa-miR-200b-3p AP1S2 2.11744072703209 1.66710572104191e-43 -0.496390996685573 3.28637648180757e-10 MirTarget;TargetScan -0.173857287456663 3.05104267622167e-26 NA NA NA hsa-miR-200c-3p AP1S2 2.07038651806183 6.84613386286599e-51 -0.496390996685573 3.28637648180757e-10 MirTarget;miRNATAP -0.195915746422791 1.44749928423614e-27 NA NA NA hsa-miR-28-5p AP2A2 -0.14267073663385 0.0497619246260571 0.0276176473817644 0.559431685651471 miRanda -0.117522775082671 1.3499752433353e-07 NA NA NA hsa-miR-28-5p AP2B1 -0.14267073663385 0.0497619246260571 0.256868055359782 0.00182779940285162 miRanda -0.218773775664612 2.05664703731146e-08 NA NA NA hsa-miR-141-3p APBB2 2.99777540204168 1.26370498493024e-78 -0.387682647024633 0.000198063436440459 MirTarget;TargetScan -0.112170596783828 2.6642528251022e-08 NA NA NA hsa-miR-28-5p APC2 -0.14267073663385 0.0497619246260571 0.94072973482498 4.47395383461655e-10 mirMAP -0.274501081998138 0.000152045555835454 NA NA NA hsa-miR-145-5p APH1A -2.62703571936687 7.64402900188551e-88 0.880951296770373 4.04327073394667e-49 miRNAWalker2_validate -0.175822049334125 1.47914936534563e-35 NA NA NA hsa-miR-141-3p APOLD1 2.99777540204168 1.26370498493024e-78 -1.79825454034465 2.31789749575749e-44 TargetScan -0.327410781495122 1.77912119261345e-38 NA NA NA hsa-miR-141-3p AQP4 2.99777540204168 1.26370498493024e-78 -2.94944371494166 1.54083437012241e-32 mirMAP -0.251865826920113 4.72861914987748e-07 NA NA NA hsa-miR-200a-3p AQP4 2.55218480823434 2.96135446816238e-51 -2.94944371494166 1.54083437012241e-32 mirMAP -0.197355364504465 6.02262825014054e-05 NA NA NA hsa-miR-200b-3p AQP4 2.11744072703209 1.66710572104191e-43 -2.94944371494166 1.54083437012241e-32 mirMAP -0.154791287067836 0.00476687585768176 NA NA NA hsa-miR-200c-3p AQP4 2.07038651806183 6.84613386286599e-51 -2.94944371494166 1.54083437012241e-32 mirMAP -0.155670616049212 0.00987400760488715 NA NA NA hsa-miR-132-3p AR -0.0365213889238607 0.668598301088667 -0.998221110404377 0.000935519021681841 mirMAP -0.577618771487242 2.17447202485949e-06 NA NA NA hsa-miR-141-3p AR 2.99777540204168 1.26370498493024e-78 -0.998221110404377 0.000935519021681841 mirMAP -0.282854868987828 1.34431712973354e-06 26062412;22314666 miR 141 3p regulates the expression of androgen receptor by targeting its 3'UTR in prostate cancer LNCaP cells; After prostate cancer cell line LNCaP was transfected with miR-141-3p mimics expression levels of AR mRNA and protein in the LNCaP cells were detected by reverse transcription PCR and Western blotting respectively; The 3'untranslated regions 3'UTR of AR mRNA containing the binding site of miR-141-3p was amplified by PCR and inserted into pmiR-report vector a 3'downstream luciferase reporter gene; Transfection of miR-141-3p mimics decreased both mRNA and protein expression levels of AR in LNCaP cells; AR is a direct target gene of miR-141-3p;miR 141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein; Here we investigated the correlation of Shp expression with the cellular level of miR-141 and its effects on AR transcriptional activity in non-malignant and malignant human prostate epithelial cell lines; Phenethyl isothiocyanate a natural constituent of many edible cruciferous vegetables increased Shp expression downregulated miR-141 and inhibited AR transcriptional activity in LNCaP cells; Shp is a target for miR-141 and it is downregulated in cultured human PCa cells with the involvement of upregulation of miR-141 which promotes AR transcriptional activity ;malignant trasformation prostate cancer;prostate cancer hsa-miR-200a-3p AR 2.55218480823434 2.96135446816238e-51 -0.998221110404377 0.000935519021681841 mirMAP -0.294399228290278 2.87045055692448e-07 24391862 We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells prostate cancer hsa-miR-28-5p ARAF -0.14267073663385 0.0497619246260571 0.235957457636243 1.23308070405748e-05 miRanda;miRNATAP -0.105409266420207 4.05384033466484e-05 NA NA NA hsa-let-7e-5p ARHGAP20 0.261471269338985 0.00191077095550257 -3.512662334718 2.09645994175907e-93 miRNATAP -0.170132694450981 0.0311786551266265 NA NA NA hsa-miR-200b-3p ARHGAP20 2.11744072703209 1.66710572104191e-43 -3.512662334718 2.09645994175907e-93 MirTarget;TargetScan -0.587855218928282 3.60262846554934e-53 NA NA NA hsa-miR-200c-3p ARHGAP20 2.07038651806183 6.84613386286599e-51 -3.512662334718 2.09645994175907e-93 MirTarget;miRNATAP -0.692917700977352 3.25337232704824e-62 NA NA NA hsa-miR-141-3p ARHGAP23 2.99777540204168 1.26370498493024e-78 -0.925868681835253 5.11227832106067e-21 TargetScan -0.234505123259787 8.62418151253771e-36 NA NA NA hsa-miR-141-3p ARHGAP24 2.99777540204168 1.26370498493024e-78 -1.40822309796801 1.02598155255413e-44 TargetScan;miRNATAP -0.32825443350451 4.46501183385659e-67 NA NA NA hsa-miR-200a-3p ARHGAP24 2.55218480823434 2.96135446816238e-51 -1.40822309796801 1.02598155255413e-44 miRNATAP -0.281391263081028 2.01960634538128e-49 NA NA NA hsa-let-7e-5p ARHGAP26 0.261471269338985 0.00191077095550257 -1.50827592959053 4.39412178107472e-38 mirMAP -0.306259713742504 7.09910105670704e-10 NA NA NA hsa-miR-200b-3p ARHGAP26 2.11744072703209 1.66710572104191e-43 -1.50827592959053 4.39412178107472e-38 TargetScan -0.219379957196502 7.64078027165699e-18 NA NA NA hsa-miR-200b-3p ARHGAP28 2.11744072703209 1.66710572104191e-43 -1.18133820684714 1.35940404125866e-14 MirTarget -0.367852292575954 9.07117006434399e-31 NA NA NA hsa-miR-200c-3p ARHGAP28 2.07038651806183 6.84613386286599e-51 -1.18133820684714 1.35940404125866e-14 MirTarget -0.433857431729715 1.44530249447599e-35 NA NA NA hsa-miR-132-3p ARHGAP32 -0.0365213889238607 0.668598301088667 0.428981349890582 9.04481455196716e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.220067441144533 6.75438325916112e-07 NA NA NA hsa-miR-28-5p ARHGAP32 -0.14267073663385 0.0497619246260571 0.428981349890582 9.04481455196716e-05 miRanda -0.357813655513258 4.69862929924358e-12 NA NA NA hsa-miR-200b-3p ARHGAP6 2.11744072703209 1.66710572104191e-43 -1.65158600785283 1.63613207715144e-36 MirTarget;TargetScan -0.336161658840228 2.02541915108007e-33 NA NA NA hsa-miR-200c-3p ARHGAP6 2.07038651806183 6.84613386286599e-51 -1.65158600785283 1.63613207715144e-36 MirTarget -0.455407011389869 3.02891850245455e-52 NA NA NA hsa-miR-28-5p ARHGAP8 -0.14267073663385 0.0497619246260571 1.29054868351649 1.27181467936902e-24 miRanda -0.123720338679521 0.0455894799146789 NA NA NA hsa-let-7e-5p ARHGEF15 0.261471269338985 0.00191077095550257 -1.84812432248598 8.12337932106921e-59 MirTarget;miRNATAP -0.121720406780551 0.0156765754165559 NA NA NA hsa-miR-28-5p ARHGEF16 -0.14267073663385 0.0497619246260571 1.35329840541901 1.42152949394676e-31 miRanda -0.311713075778674 4.38350949037839e-08 NA NA NA hsa-let-7e-5p ARHGEF38 0.261471269338985 0.00191077095550257 0.068700772974903 0.775133796982847 miRNATAP -0.364796332485804 0.000201531174666177 NA NA NA hsa-miR-200b-3p ARHGEF6 2.11744072703209 1.66710572104191e-43 -1.70444720138668 2.70249068312332e-44 mirMAP -0.284590975288989 7.43947398843613e-27 NA NA NA hsa-miR-132-3p ARID2 -0.0365213889238607 0.668598301088667 0.0126196265480711 0.870504230097088 MirTarget;miRNATAP -0.16006571542131 2.66711224768509e-07 NA NA NA hsa-miR-141-3p ARID5B 2.99777540204168 1.26370498493024e-78 -1.75348784333996 3.13677991957117e-58 TargetScan;miRNATAP -0.280948187617732 4.18108004318212e-38 NA NA NA hsa-miR-200a-3p ARID5B 2.55218480823434 2.96135446816238e-51 -1.75348784333996 3.13677991957117e-58 miRNATAP -0.243782580512392 1.53232763689101e-29 NA NA NA hsa-miR-200b-3p ARID5B 2.11744072703209 1.66710572104191e-43 -1.75348784333996 3.13677991957117e-58 TargetScan -0.250124110263959 4.1513307469872e-25 NA NA NA hsa-miR-141-3p ARL10 2.99777540204168 1.26370498493024e-78 -1.27075340213045 4.44946132830112e-20 mirMAP -0.255875769218993 1.89378754462476e-21 NA NA NA hsa-miR-200a-3p ARL10 2.55218480823434 2.96135446816238e-51 -1.27075340213045 4.44946132830112e-20 mirMAP -0.225360892231359 2.02409156045167e-17 NA NA NA hsa-miR-200b-3p ARL10 2.11744072703209 1.66710572104191e-43 -1.27075340213045 4.44946132830112e-20 mirMAP -0.226791773718429 1.9535397625489e-14 NA NA NA hsa-miR-200c-3p ARL10 2.07038651806183 6.84613386286599e-51 -1.27075340213045 4.44946132830112e-20 mirMAP -0.26267365837357 6.6367374427532e-16 NA NA NA hsa-miR-200b-3p ARL15 2.11744072703209 1.66710572104191e-43 -0.940546011404162 6.29941456769943e-17 MirTarget -0.168231453421128 2.57781942131185e-12 NA NA NA hsa-miR-200c-3p ARL15 2.07038651806183 6.84613386286599e-51 -0.940546011404162 6.29941456769943e-17 MirTarget -0.218958943423556 7.83247406818381e-17 NA NA NA hsa-miR-28-5p ARL17A -0.14267073663385 0.0497619246260571 -0.076616628706041 0.376773217715529 miRanda -0.116838808707706 0.00459030737152711 NA NA NA hsa-miR-141-3p ARL4A 2.99777540204168 1.26370498493024e-78 -1.62430631843352 2.32437289801249e-48 TargetScan -0.227743863635866 1.88476218639659e-24 NA NA NA hsa-miR-28-5p ARL6IP4 -0.14267073663385 0.0497619246260571 0.502725444320326 1.62774393703499e-06 miRanda -0.187164035456642 0.000188216832903953 NA NA NA hsa-miR-28-5p ARMC5 -0.14267073663385 0.0497619246260571 0.672611492140303 1.59874426366769e-13 miRanda -0.281851896737958 1.02406182812613e-10 NA NA NA hsa-miR-28-5p ARMC7 -0.14267073663385 0.0497619246260571 0.786794624029855 9.0622398933339e-30 miRanda -0.125003459010202 0.000256153442255009 NA NA NA hsa-miR-28-5p ARMC9 -0.14267073663385 0.0497619246260571 1.05145638032088 4.80180385675785e-40 miRanda -0.181814932736477 4.29206202175496e-06 NA NA NA hsa-miR-141-3p ARRB1 2.99777540204168 1.26370498493024e-78 -1.06393291402185 2.28886647765329e-23 MirTarget -0.169399514712247 7.04141832845205e-16 NA NA NA hsa-miR-200a-3p ARRB1 2.55218480823434 2.96135446816238e-51 -1.06393291402185 2.28886647765329e-23 MirTarget -0.11307553284225 5.52871088016413e-08 NA NA NA hsa-miR-200b-3p ARRDC3 2.11744072703209 1.66710572104191e-43 -1.46664623321918 4.94729531970204e-49 TargetScan -0.187791490987278 1.63467196161948e-17 NA NA NA hsa-let-7e-5p ARRDC4 0.261471269338985 0.00191077095550257 -1.23874511119573 2.14470595441068e-34 MirTarget;miRNATAP -0.184758543827156 1.79581758988011e-05 NA NA NA hsa-miR-200b-3p ASAP1 2.11744072703209 1.66710572104191e-43 -0.0548553794814568 0.497007616900824 MirTarget;TargetScan -0.112177041944169 3.33727389527842e-11 NA NA NA hsa-miR-200c-3p ASAP1 2.07038651806183 6.84613386286599e-51 -0.0548553794814568 0.497007616900824 MirTarget;miRNATAP -0.116341148591877 4.24555570728894e-10 NA NA NA hsa-miR-141-3p ASB1 2.99777540204168 1.26370498493024e-78 -0.931546146396313 1.15209695972474e-50 mirMAP -0.153851312045284 9.28909691694435e-36 NA NA NA hsa-miR-200a-3p ASB1 2.55218480823434 2.96135446816238e-51 -0.931546146396313 1.15209695972474e-50 mirMAP -0.116764738591083 2.70366908769873e-21 NA NA NA hsa-miR-28-5p ASB8 -0.14267073663385 0.0497619246260571 -0.209242682677155 0.000120963170245691 miRanda -0.187314696249896 2.48215666088341e-13 NA NA NA hsa-miR-141-3p ASPH 2.99777540204168 1.26370498493024e-78 -1.12086191770924 5.5588309537676e-19 MirTarget -0.239393973529425 9.54556491107484e-23 NA NA NA hsa-miR-200a-3p ASPH 2.55218480823434 2.96135446816238e-51 -1.12086191770924 5.5588309537676e-19 MirTarget -0.248624904622607 1.82700849189393e-25 NA NA NA hsa-miR-200b-3p ASPH 2.11744072703209 1.66710572104191e-43 -1.12086191770924 5.5588309537676e-19 MirTarget -0.271451416011742 1.52965360933306e-24 NA NA NA hsa-miR-200c-3p ASPH 2.07038651806183 6.84613386286599e-51 -1.12086191770924 5.5588309537676e-19 MirTarget -0.291821248227008 1.82468422060917e-23 NA NA NA hsa-miR-141-3p ASTN1 2.99777540204168 1.26370498493024e-78 -2.96085678510482 6.59267881470187e-30 MirTarget;miRNATAP -0.524681039602948 9.72053126549743e-25 NA NA NA hsa-miR-200a-3p ASTN1 2.55218480823434 2.96135446816238e-51 -2.96085678510482 6.59267881470187e-30 MirTarget;miRNATAP -0.35966082246518 1.67131671710867e-12 NA NA NA hsa-miR-141-3p ASXL3 2.99777540204168 1.26370498493024e-78 -2.85950771371795 2.17967881661421e-39 TargetScan -0.487615242095634 6.68305587565936e-30 NA NA NA hsa-miR-200b-3p ASXL3 2.11744072703209 1.66710572104191e-43 -2.85950771371795 2.17967881661421e-39 TargetScan -0.403978272871675 2.2026960754013e-17 NA NA NA hsa-miR-200a-3p ATE1 2.55218480823434 2.96135446816238e-51 -0.716130141253612 1.69873538155502e-08 MirTarget -0.117478135244148 1.34073680493748e-06 NA NA NA hsa-miR-200b-3p ATF7 2.11744072703209 1.66710572104191e-43 -0.8075699517726 1.70008219567476e-38 mirMAP -0.10198500385476 7.26290508917116e-14 NA NA NA hsa-miR-141-3p ATG2B 2.99777540204168 1.26370498493024e-78 -0.6886793008584 1.71011793794089e-19 MirTarget -0.103930680521897 3.85991814317682e-12 NA NA NA hsa-miR-200b-3p ATP11B 2.11744072703209 1.66710572104191e-43 -0.93480335074252 2.43097161001357e-15 TargetScan -0.198360455198706 2.54957794634043e-15 NA NA NA hsa-miR-200b-3p ATP11C 2.11744072703209 1.66710572104191e-43 -0.696460875250057 2.28099753397118e-14 MirTarget;TargetScan -0.173367270880293 1.99961655117013e-19 NA NA NA hsa-miR-200c-3p ATP11C 2.07038651806183 6.84613386286599e-51 -0.696460875250057 2.28099753397118e-14 MirTarget -0.146062845925123 8.12451102058996e-12 NA NA NA hsa-miR-132-3p ATP6V0E1 -0.0365213889238607 0.668598301088667 0.38487806855278 3.42056300307015e-10 miRNAWalker2_validate -0.100144558249853 6.06677528546474e-05 NA NA NA hsa-miR-28-5p ATP6V0E2 -0.14267073663385 0.0497619246260571 0.872283749869195 4.38899889470735e-16 mirMAP -0.244951750252772 2.29066524098679e-06 NA NA NA hsa-miR-143-3p ATP6V1A -1.23248181631499 4.74160976678504e-28 0.24837236966975 3.90813339126473e-05 MirTarget;miRNATAP -0.117091076728238 3.83342959221613e-11 NA NA NA hsa-miR-141-3p ATP8A1 2.99777540204168 1.26370498493024e-78 -1.26773424605015 1.41240612435128e-18 MirTarget;TargetScan -0.207098946249202 2.27002269011341e-13 NA NA NA hsa-miR-200a-3p ATP8A1 2.55218480823434 2.96135446816238e-51 -1.26773424605015 1.41240612435128e-18 MirTarget -0.184709409618299 3.00159404534449e-11 NA NA NA hsa-miR-141-3p ATP8A2 2.99777540204168 1.26370498493024e-78 -0.638077713608567 0.00506971588278745 TargetScan -0.184472539211495 3.00620922741722e-05 NA NA NA hsa-miR-200a-3p ATP9A 2.55218480823434 2.96135446816238e-51 -0.610933422922605 2.88362006166621e-10 mirMAP -0.11122818353066 1.87847912692278e-09 NA NA NA hsa-miR-28-5p ATPAF1 -0.14267073663385 0.0497619246260571 -0.162517192737524 0.00531751879757489 PITA;miRanda;miRNATAP -0.121883670377972 1.03894860881348e-05 NA NA NA hsa-miR-28-5p ATRNL1 -0.14267073663385 0.0497619246260571 -0.735629381854826 0.0208064652732134 MirTarget;miRanda -0.528569962012974 0.000487200551841339 NA NA NA hsa-miR-132-3p ATXN1 -0.0365213889238607 0.668598301088667 -0.114435417261807 0.172447028305803 miRNATAP -0.113221556133624 0.000833299519781539 NA NA NA hsa-miR-141-3p ATXN1 2.99777540204168 1.26370498493024e-78 -0.114435417261807 0.172447028305803 MirTarget;TargetScan;miRNATAP -0.102729733109084 1.8797304555441e-10 NA NA NA hsa-miR-200c-3p ATXN1 2.07038651806183 6.84613386286599e-51 -0.114435417261807 0.172447028305803 MirTarget;miRNATAP -0.106226800982093 4.42599639047694e-08 NA NA NA hsa-miR-141-3p ATXN1L 2.99777540204168 1.26370498493024e-78 -0.967047544306038 3.56077228221018e-35 mirMAP -0.137643141167723 7.54787476623612e-19 NA NA NA hsa-miR-200a-3p ATXN1L 2.55218480823434 2.96135446816238e-51 -0.967047544306038 3.56077228221018e-35 mirMAP -0.118089190502755 1.25634516696957e-14 NA NA NA hsa-miR-200b-3p ATXN1L 2.11744072703209 1.66710572104191e-43 -0.967047544306038 3.56077228221018e-35 TargetScan -0.124050588853429 3.64636204609545e-13 NA NA NA hsa-miR-200c-3p ATXN1L 2.07038651806183 6.84613386286599e-51 -0.967047544306038 3.56077228221018e-35 miRNATAP -0.140101059576771 7.94636330797225e-14 NA NA NA hsa-miR-145-5p ATXN7L3 -2.62703571936687 7.64402900188551e-88 0.53052790945832 3.35458942024545e-29 miRNATAP -0.10671594149144 5.08653026614155e-22 NA NA NA hsa-miR-141-3p B3GALT1 2.99777540204168 1.26370498493024e-78 -3.98103430858862 1.44388634349729e-75 TargetScan -0.559992845905164 1.26341448750432e-36 NA NA NA hsa-miR-28-5p B3GALT4 -0.14267073663385 0.0497619246260571 0.463435175029749 5.58445598817781e-06 miRanda -0.144809845762043 0.00301366337812068 NA NA NA hsa-miR-141-3p B3GNT5 2.99777540204168 1.26370498493024e-78 -1.53531290629438 1.16098549639906e-19 TargetScan -0.188491236928403 1.72284861583692e-08 NA NA NA hsa-miR-200b-3p B4GALT6 2.11744072703209 1.66710572104191e-43 -1.52811154944873 8.28896953314112e-40 MirTarget -0.217522704740941 8.03293650410985e-18 NA NA NA hsa-miR-200c-3p B4GALT6 2.07038651806183 6.84613386286599e-51 -1.52811154944873 8.28896953314112e-40 MirTarget;miRNATAP -0.241418214675955 3.86818529215459e-18 NA NA NA hsa-miR-141-3p BACE1 2.99777540204168 1.26370498493024e-78 -0.666769604583787 2.96043912347582e-20 TargetScan;miRNATAP -0.172123154005193 7.39237012295794e-36 NA NA NA hsa-miR-200a-3p BACE1 2.55218480823434 2.96135446816238e-51 -0.666769604583787 2.96043912347582e-20 mirMAP;miRNATAP -0.150780816777556 2.12822618790304e-28 NA NA NA hsa-let-7e-5p BACH1 0.261471269338985 0.00191077095550257 -0.493079199088389 1.91147885323467e-08 MirTarget;miRNATAP -0.100385186049412 0.00550250811481171 NA NA NA hsa-miR-141-3p BACH2 2.99777540204168 1.26370498493024e-78 -1.73835492420195 2.12716972085336e-31 TargetScan -0.350944611352891 7.40934421569497e-34 NA NA NA hsa-miR-200a-3p BACH2 2.55218480823434 2.96135446816238e-51 -1.73835492420195 2.12716972085336e-31 mirMAP -0.288332992592871 1.23167881048994e-23 NA NA NA hsa-miR-200b-3p BACH2 2.11744072703209 1.66710572104191e-43 -1.73835492420195 2.12716972085336e-31 TargetScan;mirMAP -0.279239130616483 4.6547126152686e-18 NA NA NA hsa-miR-200c-3p BACH2 2.07038651806183 6.84613386286599e-51 -1.73835492420195 2.12716972085336e-31 mirMAP -0.343576698109244 1.88017069684532e-22 NA NA NA hsa-miR-28-5p BAG1 -0.14267073663385 0.0497619246260571 0.415270048181819 1.74825976512713e-05 miRanda -0.307899469150691 1.6573691753667e-11 NA NA NA hsa-miR-143-3p BBC3 -1.23248181631499 4.74160976678504e-28 1.65385724902316 1.48973116107111e-30 miRNATAP -0.217374027351567 7.85719613622932e-07 NA NA NA hsa-miR-28-5p BBS1 -0.14267073663385 0.0497619246260571 -0.0933887460229856 0.273588503662833 miRanda -0.28940058756879 4.91592702721265e-13 NA NA NA hsa-miR-132-3p BBX -0.0365213889238607 0.668598301088667 -0.606457956375014 6.12159507795877e-13 miRNATAP -0.102542745372093 0.00301251202855815 NA NA NA hsa-miR-28-5p BCAM -0.14267073663385 0.0497619246260571 0.514670465767451 0.00080836907714589 PITA;miRanda -0.64381725099197 3.09853416103942e-19 NA NA NA hsa-miR-200c-3p BCAP29 2.07038651806183 6.84613386286599e-51 -0.283272713723518 1.20011320724944e-05 MirTarget -0.100891380466071 1.57910803733562e-11 NA NA NA hsa-miR-28-5p BDKRB2 -0.14267073663385 0.0497619246260571 -0.625395772277269 9.23772700388795e-08 mirMAP -0.17391393060575 0.00195176900999036 NA NA NA hsa-miR-28-5p BHLHE40 -0.14267073663385 0.0497619246260571 0.408671974638585 0.000468982708659732 miRanda -0.470045059510164 8.62962982184735e-18 NA NA NA hsa-miR-200b-3p BHLHE41 2.11744072703209 1.66710572104191e-43 -1.52791209922438 3.58240496427099e-30 MirTarget;TargetScan -0.189675934129512 7.87834639798827e-11 NA NA NA hsa-miR-200c-3p BHLHE41 2.07038651806183 6.84613386286599e-51 -1.52791209922438 3.58240496427099e-30 MirTarget;miRNATAP -0.218575068442399 8.90412851610278e-12 NA NA NA hsa-miR-200b-3p BICC1 2.11744072703209 1.66710572104191e-43 -1.8344531920319 2.52630597418105e-16 TargetScan -0.436882111968367 2.61515727755522e-20 NA NA NA hsa-miR-200c-3p BLCAP 2.07038651806183 6.84613386286599e-51 -0.61293600830262 7.0045347509599e-26 MirTarget -0.110128680305086 1.21146020661216e-15 NA NA NA hsa-let-7e-5p BMP2K 0.261471269338985 0.00191077095550257 -0.606665941487059 3.28263902417702e-08 miRNAWalker2_validate -0.110871945655889 0.0143432932517263 NA NA NA hsa-miR-205-5p BMPR1B -1.70057043266505 1.20976599540743e-09 2.3325512314431 1.87054528568578e-09 miRNATAP -0.128948367199523 0.00663542809472005 NA NA NA hsa-miR-200b-3p BMPR2 2.11744072703209 1.66710572104191e-43 -0.619963448559116 4.34614935044474e-16 mirMAP -0.121047661495268 8.73119456445721e-14 NA NA NA hsa-miR-200c-3p BMPR2 2.07038651806183 6.84613386286599e-51 -0.619963448559116 4.34614935044474e-16 mirMAP -0.13697648800764 1.55247615315968e-14 NA NA NA hsa-miR-141-3p BNC2 2.99777540204168 1.26370498493024e-78 -0.776172590713737 2.35134421190691e-07 TargetScan -0.386175050807488 1.09867494793985e-43 NA NA NA hsa-miR-200b-3p BNC2 2.11744072703209 1.66710572104191e-43 -0.776172590713737 2.35134421190691e-07 MirTarget;TargetScan -0.364379236825585 3.65519345520506e-32 NA NA NA hsa-miR-200c-3p BNC2 2.07038651806183 6.84613386286599e-51 -0.776172590713737 2.35134421190691e-07 MirTarget -0.45901128056021 8.37829403854513e-43 NA NA NA hsa-miR-200b-3p BNIP2 2.11744072703209 1.66710572104191e-43 -0.80045076092255 4.23218754614542e-44 mirMAP -0.128386639673051 8.65540392356891e-25 NA NA NA hsa-miR-200c-3p BNIP2 2.07038651806183 6.84613386286599e-51 -0.80045076092255 4.23218754614542e-44 mirMAP -0.139960678206022 2.2965922170214e-24 NA NA NA hsa-miR-132-3p BRWD1 -0.0365213889238607 0.668598301088667 -0.031864319705571 0.661126150344288 MirTarget -0.135417899455371 3.65615570752795e-06 NA NA NA hsa-miR-132-3p BTG2 -0.0365213889238607 0.668598301088667 -0.809620825866558 5.59677057319634e-08 MirTarget;miRNATAP -0.255171097355259 2.59143053656702e-05 NA NA NA hsa-miR-132-3p BTRC -0.0365213889238607 0.668598301088667 0.120536048906525 0.159286798668058 MirTarget -0.16624989082982 1.42128564671786e-06 NA NA NA hsa-miR-28-5p BTRC -0.14267073663385 0.0497619246260571 0.120536048906525 0.159286798668058 miRanda -0.245382923565365 1.23962341723426e-09 NA NA NA hsa-miR-141-3p BVES 2.99777540204168 1.26370498493024e-78 -1.62299717888388 6.51596614677981e-33 mirMAP -0.3200976190746 7.89312634207751e-34 NA NA NA hsa-miR-200a-3p BVES 2.55218480823434 2.96135446816238e-51 -1.62299717888388 6.51596614677981e-33 mirMAP -0.295934187886683 6.15942660034593e-30 NA NA NA hsa-let-7e-5p C10orf105 0.261471269338985 0.00191077095550257 -1.37741869836931 5.7847382458008e-20 mirMAP -0.144574212944487 0.0219704228016203 NA NA NA hsa-miR-141-3p C11orf21 2.99777540204168 1.26370498493024e-78 -0.329432320728833 0.0780147278787802 mirMAP -0.13539699924965 0.000189807986797707 NA NA NA hsa-miR-28-5p C16orf52 -0.14267073663385 0.0497619246260571 -0.439770788571493 2.5380865851945e-12 miRNATAP -0.110568247183795 0.000252443890650864 NA NA NA hsa-miR-200b-3p C17orf51 2.11744072703209 1.66710572104191e-43 -1.38118393054696 1.19626145693611e-32 mirMAP -0.312872287849088 2.31831204331372e-37 NA NA NA hsa-miR-200c-3p C17orf51 2.07038651806183 6.84613386286599e-51 -1.38118393054696 1.19626145693611e-32 mirMAP -0.364192605482146 3.68097874270194e-42 NA NA NA hsa-miR-28-5p C17orf82 -0.14267073663385 0.0497619246260571 0.653363977503569 0.000594375221828843 mirMAP -0.397360424830677 1.14647275000386e-05 NA NA NA hsa-miR-132-3p C1orf21 -0.0365213889238607 0.668598301088667 -0.468027970401431 0.00105985509741778 mirMAP -0.229222764056851 7.48351728701708e-05 NA NA NA hsa-miR-141-3p C20orf194 2.99777540204168 1.26370498493024e-78 -1.30628408327392 8.98863433785682e-65 TargetScan;mirMAP -0.240321639489277 4.31437364630982e-57 NA NA NA hsa-miR-200a-3p C20orf194 2.55218480823434 2.96135446816238e-51 -1.30628408327392 8.98863433785682e-65 mirMAP -0.174018111512723 8.13873240561337e-30 NA NA NA hsa-miR-200b-3p C4orf32 2.11744072703209 1.66710572104191e-43 -0.941241213607787 1.31431030094497e-11 TargetScan -0.10951191541219 0.00024076472896205 NA NA NA hsa-miR-145-5p CA12 -2.62703571936687 7.64402900188551e-88 1.1080341989271 2.19542324257114e-05 mirMAP -0.176650683962353 0.00373847067408946 NA NA NA hsa-miR-28-5p CA12 -0.14267073663385 0.0497619246260571 1.1080341989271 2.19542324257114e-05 mirMAP -1.22594667011082 6.41858377268708e-24 NA NA NA hsa-miR-200b-3p CACHD1 2.11744072703209 1.66710572104191e-43 -2.56774598917352 6.13969823521877e-72 TargetScan -0.337489505775331 1.43695728531767e-25 NA NA NA hsa-miR-200b-3p CACNA1C 2.11744072703209 1.66710572104191e-43 -0.825897678032819 4.27711725647878e-10 MirTarget;TargetScan -0.118126560258071 2.93890482056991e-05 NA NA NA hsa-miR-200c-3p CACNA1C 2.07038651806183 6.84613386286599e-51 -0.825897678032819 4.27711725647878e-10 MirTarget -0.177083982550756 1.05519360943015e-08 NA NA NA hsa-miR-145-5p CACNA1D -2.62703571936687 7.64402900188551e-88 1.29741717389352 5.48962840197304e-09 MirTarget;miRNATAP -0.169999006636138 0.00110885711768601 NA NA NA hsa-miR-141-3p CACNA2D1 2.99777540204168 1.26370498493024e-78 -3.13664353232148 8.51761818806015e-30 TargetScan -0.686981792019036 4.96940699743537e-38 NA NA NA hsa-miR-200b-3p CACNA2D1 2.11744072703209 1.66710572104191e-43 -3.13664353232148 8.51761818806015e-30 TargetScan -0.611285006989797 4.91380566101455e-25 NA NA NA hsa-miR-205-5p CACNA2D2 -1.70057043266505 1.20976599540743e-09 0.520191856000968 0.0224604042502349 miRNATAP -0.114792729291005 3.09088850806225e-05 NA NA NA hsa-miR-28-5p CACNG4 -0.14267073663385 0.0497619246260571 2.21159891256783 3.76360584804154e-13 miRanda -0.632449765922558 1.63314781237986e-05 NA NA NA hsa-miR-141-3p CADM2 2.99777540204168 1.26370498493024e-78 -2.4039007121495 1.66875358505835e-18 TargetScan;miRNATAP -0.404306118506428 4.80251553001281e-14 NA NA NA hsa-miR-200a-3p CADM2 2.55218480823434 2.96135446816238e-51 -2.4039007121495 1.66875358505835e-18 miRNATAP -0.252610300188707 2.01474761554171e-06 NA NA NA hsa-miR-28-5p CALCOCO1 -0.14267073663385 0.0497619246260571 -1.08289042748634 4.79337264485307e-51 miRanda -0.143823356702789 8.02577597264752e-05 NA NA NA hsa-miR-28-5p CALCOCO2 -0.14267073663385 0.0497619246260571 -0.438580916376234 2.42826269547857e-08 miRanda -0.198957671269254 1.11358465771385e-07 NA NA NA hsa-miR-141-3p CALCR 2.99777540204168 1.26370498493024e-78 -2.09521121092609 1.65401230978274e-27 MirTarget;TargetScan;miRNATAP -0.362458535071316 9.4058665350797e-22 NA NA NA hsa-miR-200a-3p CALCR 2.55218480823434 2.96135446816238e-51 -2.09521121092609 1.65401230978274e-27 MirTarget;miRNATAP -0.272238498570481 4.07601585086017e-13 NA NA NA hsa-miR-200b-3p CALCR 2.11744072703209 1.66710572104191e-43 -2.09521121092609 1.65401230978274e-27 MirTarget -0.276220054174993 4.13927686220689e-11 NA NA NA hsa-miR-200c-3p CALCR 2.07038651806183 6.84613386286599e-51 -2.09521121092609 1.65401230978274e-27 MirTarget -0.355606068072519 8.24857300495474e-15 NA NA NA hsa-let-7e-5p CALD1 0.261471269338985 0.00191077095550257 -0.977982331069182 1.18727276687937e-21 miRNATAP -0.108852398824696 0.0112463528627116 NA NA NA hsa-miR-141-3p CALN1 2.99777540204168 1.26370498493024e-78 -2.70813184176793 2.87746517163719e-26 mirMAP -0.605072642812346 8.51135502529506e-35 NA NA NA hsa-miR-200c-3p CAMK1D 2.07038651806183 6.84613386286599e-51 0.17033798810489 0.172578200817693 mirMAP -0.10370164232462 0.000360827289623906 NA NA NA hsa-miR-200b-3p CAMK2D 2.11744072703209 1.66710572104191e-43 -0.878893243229353 8.81421222940348e-16 TargetScan;mirMAP -0.176484130686564 3.1915455415824e-14 NA NA NA hsa-miR-28-5p CANT1 -0.14267073663385 0.0497619246260571 1.19121908849889 2.01312112605851e-40 miRanda;miRNATAP -0.31350040187146 1.39014322710422e-12 NA NA NA hsa-miR-28-5p CASC2 -0.14267073663385 0.0497619246260571 -0.0591451463253274 0.56145154040616 miRanda -0.214324545590939 9.02943345410797e-06 NA NA NA hsa-miR-200b-3p CASP10 2.11744072703209 1.66710572104191e-43 -1.06975607492518 1.19238028683847e-21 mirMAP -0.239445518155442 5.07791301456485e-24 NA NA NA hsa-miR-200c-3p CASP10 2.07038651806183 6.84613386286599e-51 -1.06975607492518 1.19238028683847e-21 mirMAP -0.273509969637675 6.53447298083599e-26 NA NA NA hsa-miR-132-3p CASP7 -0.0365213889238607 0.668598301088667 0.0960684078333616 0.182578616272612 miRNAWalker2_validate;MirTarget -0.107439780267955 0.000220260395052539 NA NA NA hsa-miR-145-5p CASZ1 -2.62703571936687 7.64402900188551e-88 0.650698025577658 4.38286118706725e-10 miRNATAP -0.182104865024767 4.34115005275873e-14 NA NA NA hsa-miR-28-5p CBFA2T3 -0.14267073663385 0.0497619246260571 -0.236084529668508 0.189514237639123 mirMAP -0.485479312063744 1.14869653795936e-08 NA NA NA hsa-miR-141-3p CBL 2.99777540204168 1.26370498493024e-78 -0.680370172816626 1.00788843412567e-17 MirTarget;TargetScan;mirMAP -0.115106125372554 1.1738554188593e-13 NA NA NA hsa-miR-200a-3p CBL 2.55218480823434 2.96135446816238e-51 -0.680370172816626 1.00788843412567e-17 MirTarget;mirMAP -0.106984119943656 2.26578579492675e-12 NA NA NA hsa-miR-200b-3p CBL 2.11744072703209 1.66710572104191e-43 -0.680370172816626 1.00788843412567e-17 MirTarget;TargetScan;mirMAP -0.118437584281099 2.87888645461771e-12 NA NA NA hsa-miR-200c-3p CBL 2.07038651806183 6.84613386286599e-51 -0.680370172816626 1.00788843412567e-17 MirTarget;mirMAP -0.136179026309206 2.63066757150576e-13 NA NA NA hsa-miR-132-3p CBWD3 -0.0365213889238607 0.668598301088667 0.89217842214657 3.21894092107502e-14 MirTarget -0.108959962678234 0.0243677653272345 NA NA NA hsa-miR-143-3p CCDC110 -1.23248181631499 4.74160976678504e-28 -0.0639347612985626 0.61012214160871 MirTarget -0.118048160586829 0.00143845461718335 NA NA NA hsa-miR-28-5p CCDC113 -0.14267073663385 0.0497619246260571 0.149223101788104 0.136932129872727 miRanda;miRNATAP -0.148195425613187 0.00190132838114588 NA NA NA hsa-miR-28-5p CCDC114 -0.14267073663385 0.0497619246260571 1.16840637134549 3.00376939451887e-11 miRanda -0.296693787504866 0.000456912265203965 NA NA NA hsa-let-7e-5p CCDC141 0.261471269338985 0.00191077095550257 -2.66328285938222 3.16825005958641e-51 MirTarget;miRNATAP -0.316625679092534 3.91039066626923e-05 NA NA NA hsa-miR-143-3p CCDC58 -1.23248181631499 4.74160976678504e-28 0.681522760656601 2.70177513008055e-20 MirTarget;miRNATAP -0.154554260630169 2.57785905015281e-12 NA NA NA hsa-miR-141-3p CCDC80 2.99777540204168 1.26370498493024e-78 -1.64278449223908 9.9933942504804e-25 MirTarget;TargetScan -0.522371143852423 6.06710122719767e-71 NA NA NA hsa-miR-200a-3p CCDC80 2.55218480823434 2.96135446816238e-51 -1.64278449223908 9.9933942504804e-25 MirTarget -0.438329461131822 1.07849539272779e-49 NA NA NA hsa-miR-200b-3p CCDC82 2.11744072703209 1.66710572104191e-43 -1.56728659216967 4.7319112846567e-46 MirTarget;TargetScan -0.25354261389417 3.90235854787021e-26 NA NA NA hsa-miR-200c-3p CCDC82 2.07038651806183 6.84613386286599e-51 -1.56728659216967 4.7319112846567e-46 MirTarget -0.300076767632542 2.50086532254082e-30 NA NA NA hsa-miR-28-5p CCDC85A -0.14267073663385 0.0497619246260571 -2.63514416883509 8.247493889982e-55 miRanda -0.198190978658007 0.0217102405686434 NA NA NA hsa-miR-28-5p CCDC87 -0.14267073663385 0.0497619246260571 1.38078268229956 9.83612478312899e-22 miRanda -0.498038418591484 8.14796611713182e-13 NA NA NA hsa-let-7e-5p CCND2 0.261471269338985 0.00191077095550257 -1.32381712777542 1.10807863083966e-33 miRNATAP -0.168033346737038 0.000309648297817392 NA NA NA hsa-miR-141-3p CCND2 2.99777540204168 1.26370498493024e-78 -1.32381712777542 1.10807863083966e-33 MirTarget;TargetScan -0.300723945575078 8.35441899721039e-47 NA NA NA hsa-miR-200a-3p CCND2 2.55218480823434 2.96135446816238e-51 -1.32381712777542 1.10807863083966e-33 MirTarget -0.261226562912324 4.31939405604759e-36 NA NA NA hsa-miR-28-5p CCNDBP1 -0.14267073663385 0.0497619246260571 -0.725809699931222 3.00753297514094e-26 miRanda -0.172490460917306 2.48035110164691e-07 NA NA NA hsa-miR-28-5p CCNG2 -0.14267073663385 0.0497619246260571 -0.149650768150032 0.140842306998986 miRanda -0.202065115294172 2.7892462854838e-05 NA NA NA hsa-miR-200b-3p CCNJL 2.11744072703209 1.66710572104191e-43 -0.24201926034273 0.130052014695587 TargetScan -0.109705735774401 0.00120234945919895 NA NA NA hsa-miR-200b-3p CCNYL1 2.11744072703209 1.66710572104191e-43 -0.335630850366162 2.14732890660635e-05 MirTarget;TargetScan -0.141068368642723 1.17774083265312e-17 NA NA NA hsa-miR-200c-3p CCNYL1 2.07038651806183 6.84613386286599e-51 -0.335630850366162 2.14732890660635e-05 MirTarget -0.123498507641419 1.41626967474554e-11 NA NA NA hsa-miR-141-3p CCPG1 2.99777540204168 1.26370498493024e-78 -0.529964991968035 4.71049768066572e-12 MirTarget;miRNATAP -0.120928259885471 3.34917437118351e-16 NA NA NA hsa-miR-200a-3p CCPG1 2.55218480823434 2.96135446816238e-51 -0.529964991968035 4.71049768066572e-12 MirTarget;miRNATAP -0.105196263517266 5.83806340900371e-13 NA NA NA hsa-let-7e-5p CCR7 0.261471269338985 0.00191077095550257 1.0923189598847 8.9400255412468e-08 miRNATAP -0.170979084096314 0.0425443007814041 NA NA NA hsa-miR-132-3p CD164 -0.0365213889238607 0.668598301088667 -0.285138667648189 0.000280402525232159 miRNAWalker2_validate;miRNATAP -0.188310804381255 2.4797384072156e-09 NA NA NA hsa-let-7e-5p CD200R1 0.261471269338985 0.00191077095550257 -1.30036146588824 9.74109467568733e-16 miRNATAP -0.153766735443711 0.0227274531731599 NA NA NA hsa-miR-200a-3p CD274 2.55218480823434 2.96135446816238e-51 -0.376984029369696 0.0181142353017598 MirTarget -0.104573951616621 0.00058439454975885 NA NA NA hsa-miR-28-5p CD2BP2 -0.14267073663385 0.0497619246260571 0.7295100071912 3.69314996005442e-25 MirTarget;miRanda -0.242214534749734 1.19789821252281e-12 NA NA NA hsa-miR-132-3p CD55 -0.0365213889238607 0.668598301088667 -0.357125668177814 0.00101673697013703 miRNAWalker2_validate -0.118990266693861 0.00697265157564722 NA NA NA hsa-miR-141-3p CD59 2.99777540204168 1.26370498493024e-78 -0.855467054419464 8.25618549169397e-22 mirMAP -0.10076056346922 1.11975519170288e-08 NA NA NA hsa-miR-141-3p CDC14A 2.99777540204168 1.26370498493024e-78 -1.23414445517375 6.16820708163778e-16 TargetScan;miRNATAP -0.136888602907261 5.43142578436724e-06 NA NA NA hsa-miR-200a-3p CDC14A 2.55218480823434 2.96135446816238e-51 -1.23414445517375 6.16820708163778e-16 miRNATAP -0.100138641411013 0.000721104667858655 NA NA NA hsa-miR-141-3p CDC14B 2.99777540204168 1.26370498493024e-78 -2.02470757063903 5.50090046332077e-71 mirMAP -0.345195446899158 1.85452830789045e-52 NA NA NA hsa-miR-200a-3p CDC14B 2.55218480823434 2.96135446816238e-51 -2.02470757063903 5.50090046332077e-71 mirMAP -0.293218947907091 2.14473413178426e-38 NA NA NA hsa-miR-200a-3p CDC42BPA 2.55218480823434 2.96135446816238e-51 -0.66924322412178 9.81806271682457e-10 mirMAP -0.150300294689266 5.12079916560305e-13 NA NA NA hsa-miR-141-3p CDC42EP3 2.99777540204168 1.26370498493024e-78 -1.05952015011567 1.54317380849048e-18 MirTarget;TargetScan -0.171981504132907 3.41196277513308e-13 NA NA NA hsa-miR-200a-3p CDC42EP3 2.55218480823434 2.96135446816238e-51 -1.05952015011567 1.54317380849048e-18 MirTarget -0.131332641557507 1.81382117073955e-08 NA NA NA hsa-miR-200b-3p CDC42EP3 2.11744072703209 1.66710572104191e-43 -1.05952015011567 1.54317380849048e-18 TargetScan -0.144303536680923 2.70557595091107e-08 NA NA NA hsa-miR-28-5p CDH18 -0.14267073663385 0.0497619246260571 -0.0522684838785148 0.841570242720998 PITA;miRanda -0.338750908305708 0.00650983425165781 NA NA NA hsa-miR-200b-3p CDH6 2.11744072703209 1.66710572104191e-43 -0.970669875320658 5.55111886434944e-15 TargetScan -0.264470815531992 3.37380877825487e-24 NA NA NA hsa-miR-28-5p CDH7 -0.14267073663385 0.0497619246260571 1.31238154715945 1.99846237004699e-05 miRanda -0.556872122656275 0.000151564494061746 NA NA NA hsa-miR-143-3p CDK12 -1.23248181631499 4.74160976678504e-28 0.200095170936883 0.046651936671646 miRNATAP -0.107365886468273 0.000301661393931013 NA NA NA hsa-miR-28-5p CDK17 -0.14267073663385 0.0497619246260571 -0.124778185173291 0.119991532413407 miRanda -0.2679902930505 1.16916140085302e-12 NA NA NA hsa-miR-145-5p CDK4 -2.62703571936687 7.64402900188551e-88 0.597969315491349 4.23701383421285e-22 miRNAWalker2_validate;miRTarBase -0.134364969525933 9.65405723067241e-21 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control lung squamous cell cancer hsa-miR-28-5p CDK5 -0.14267073663385 0.0497619246260571 1.49472759404501 6.61129562064286e-69 miRanda -0.232036778076655 1.32632021154552e-07 NA NA NA hsa-miR-141-3p CDK6 2.99777540204168 1.26370498493024e-78 -1.03099881099472 9.88361268912926e-12 TargetScan;miRNATAP -0.155074529575108 1.68227129058067e-07 NA NA NA hsa-miR-200a-3p CDK6 2.55218480823434 2.96135446816238e-51 -1.03099881099472 9.88361268912926e-12 miRNATAP -0.153245463849065 1.36473748839668e-07 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6 liver cancer hsa-miR-200b-3p CDK6 2.11744072703209 1.66710572104191e-43 -1.03099881099472 9.88361268912926e-12 mirMAP -0.174815127052701 6.39294256795547e-08 NA NA NA hsa-miR-200c-3p CDK6 2.07038651806183 6.84613386286599e-51 -1.03099881099472 9.88361268912926e-12 mirMAP -0.180928310145507 3.68922155138771e-07 NA NA NA hsa-miR-28-5p CDKN1A -0.14267073663385 0.0497619246260571 -0.254319078213554 0.025069242968496 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.294350864895331 4.29596264827348e-08 NA NA NA hsa-miR-141-3p CDON 2.99777540204168 1.26370498493024e-78 -0.991164686357028 8.70119211480039e-13 TargetScan;miRNATAP -0.171828112637553 2.1850076679971e-10 NA NA NA hsa-miR-28-5p CDON -0.14267073663385 0.0497619246260571 -0.991164686357028 8.70119211480039e-13 miRanda -0.218069047933018 0.00111790580801383 NA NA NA hsa-miR-145-5p CDR2L -2.62703571936687 7.64402900188551e-88 0.748814200369793 2.69929277775634e-18 MirTarget;miRNATAP -0.132831606499825 4.24854926303667e-11 NA NA NA hsa-miR-132-3p CDS2 -0.0365213889238607 0.668598301088667 0.0160287066828957 0.789116734676961 mirMAP -0.108977814970169 6.11196966186335e-06 NA NA NA hsa-miR-28-5p CEACAM6 -0.14267073663385 0.0497619246260571 3.14788813465337 6.1411751537789e-15 miRanda -1.28041560860565 3.67270918208962e-11 NA NA NA hsa-miR-28-5p CEACAM7 -0.14267073663385 0.0497619246260571 1.13710462023162 6.55115186081843e-05 MirTarget;miRanda -1.0999950998306 2.08904069363437e-16 NA NA NA hsa-miR-200b-3p CECR2 2.11744072703209 1.66710572104191e-43 -0.71348448769862 0.0169057220752779 TargetScan -0.259441080900268 4.10916563552115e-05 NA NA NA hsa-let-7e-5p CECR6 0.261471269338985 0.00191077095550257 0.0777973771451636 0.583031797321296 MirTarget;miRNATAP -0.132900267472565 0.0218552520494914 NA NA NA hsa-let-7e-5p CELF2 0.261471269338985 0.00191077095550257 -2.12375294826078 1.08191631254129e-58 miRNAWalker2_validate -0.211640448758577 0.000251932180152815 NA NA NA hsa-miR-141-3p CELF2 2.99777540204168 1.26370498493024e-78 -2.12375294826078 1.08191631254129e-58 mirMAP;miRNATAP -0.41339311906567 1.01135582231735e-58 NA NA NA hsa-miR-200a-3p CELF2 2.55218480823434 2.96135446816238e-51 -2.12375294826078 1.08191631254129e-58 mirMAP -0.350803565397106 1.22282287421629e-42 NA NA NA hsa-miR-200b-3p CELF2 2.11744072703209 1.66710572104191e-43 -2.12375294826078 1.08191631254129e-58 TargetScan;mirMAP -0.38083163724957 1.74055500746982e-40 NA NA NA hsa-miR-200c-3p CELF2 2.07038651806183 6.84613386286599e-51 -2.12375294826078 1.08191631254129e-58 mirMAP;miRNATAP -0.449875475207335 3.01578232376033e-47 NA NA NA hsa-miR-28-5p CENPB -0.14267073663385 0.0497619246260571 0.534770912954583 2.18865840104711e-14 miRNATAP -0.12250809067838 0.000287435178384392 NA NA NA hsa-miR-132-3p CENPP -0.0365213889238607 0.668598301088667 1.38859803247114 1.24507134095326e-33 mirMAP -0.147678097245835 0.00231094756863626 NA NA NA hsa-miR-143-3p CENPP -1.23248181631499 4.74160976678504e-28 1.38859803247114 1.24507134095326e-33 mirMAP -0.226469844314473 1.07991709671408e-10 NA NA NA hsa-miR-141-3p CEP120 2.99777540204168 1.26370498493024e-78 -0.637906841352931 9.59571458000669e-20 MirTarget;miRNATAP -0.107211534312174 5.51493473049517e-15 NA NA NA hsa-miR-200b-3p CEP68 2.11744072703209 1.66710572104191e-43 -1.31835189113776 7.12744930214818e-101 MirTarget -0.157171623230992 9.38037557270443e-28 NA NA NA hsa-miR-200c-3p CEP68 2.07038651806183 6.84613386286599e-51 -1.31835189113776 7.12744930214818e-101 MirTarget -0.185773136893312 3.69638298679941e-32 NA NA NA hsa-miR-141-3p CFL2 2.99777540204168 1.26370498493024e-78 -1.90866764374212 6.50763441219441e-93 TargetScan -0.326572218109566 4.92408445395296e-68 NA NA NA hsa-miR-200b-3p CFL2 2.11744072703209 1.66710572104191e-43 -1.90866764374212 6.50763441219441e-93 MirTarget;TargetScan -0.298081117582125 1.57474476734891e-45 NA NA NA hsa-miR-200c-3p CFL2 2.07038651806183 6.84613386286599e-51 -1.90866764374212 6.50763441219441e-93 MirTarget;miRNATAP -0.380708052394068 1.28877470594683e-63 23497265 We characterized one of the target genes of miR-200c CFL2 and demonstrated that CFL2 is overexpressed in aggressive breast cancer cell lines and can be significantly down-regulated by exogenous miR-200c breast cancer hsa-let-7e-5p CGNL1 0.261471269338985 0.00191077095550257 -0.816425464626318 5.15282597670331e-08 MirTarget;miRNATAP -0.217679545861787 0.000420446393790031 NA NA NA hsa-miR-145-5p CHAC2 -2.62703571936687 7.64402900188551e-88 0.544096936191264 4.42023817052818e-07 MirTarget -0.122101284982284 1.10969565965746e-06 NA NA NA hsa-miR-28-5p CHAD -0.14267073663385 0.0497619246260571 -0.0030842411669636 0.993051648329624 miRanda -0.898299919129268 8.28846753994342e-08 NA NA NA hsa-miR-28-5p CHD3 -0.14267073663385 0.0497619246260571 0.23471658817734 0.000437572538712428 miRanda -0.14699452182334 3.51869616627388e-06 NA NA NA hsa-miR-141-3p CHD9 2.99777540204168 1.26370498493024e-78 -1.20641724676964 1.8510450370295e-34 MirTarget;TargetScan;miRNATAP -0.182190145306071 1.03264917281218e-20 NA NA NA hsa-miR-200a-3p CHD9 2.55218480823434 2.96135446816238e-51 -1.20641724676964 1.8510450370295e-34 MirTarget;miRNATAP -0.145625348339878 4.83128038510931e-14 NA NA NA hsa-miR-200b-3p CHD9 2.11744072703209 1.66710572104191e-43 -1.20641724676964 1.8510450370295e-34 TargetScan;mirMAP -0.163983661372598 2.28493846391535e-14 NA NA NA hsa-miR-200c-3p CHD9 2.07038651806183 6.84613386286599e-51 -1.20641724676964 1.8510450370295e-34 mirMAP;miRNATAP -0.189232134031131 1.01551746966713e-15 NA NA NA hsa-miR-28-5p CHDH -0.14267073663385 0.0497619246260571 0.0931083294714723 0.508817983929441 miRanda -0.296667633251818 9.04941339500822e-06 NA NA NA hsa-miR-200c-3p CHN2 2.07038651806183 6.84613386286599e-51 -0.112685595485043 0.45906561565987 MirTarget -0.15719708908879 8.71100552677592e-06 NA NA NA hsa-miR-141-3p CHRDL1 2.99777540204168 1.26370498493024e-78 -5.39923527570506 3.1404637677735e-65 MirTarget;TargetScan -0.938805684928036 1.6382769374349e-50 NA NA NA hsa-miR-200a-3p CHRDL1 2.55218480823434 2.96135446816238e-51 -5.39923527570506 3.1404637677735e-65 MirTarget -0.745909670515544 3.13252730232654e-32 NA NA NA hsa-miR-200b-3p CHRDL1 2.11744072703209 1.66710572104191e-43 -5.39923527570506 3.1404637677735e-65 MirTarget;TargetScan -0.737728194993491 2.11393379082638e-25 NA NA NA hsa-miR-200c-3p CHRDL1 2.07038651806183 6.84613386286599e-51 -5.39923527570506 3.1404637677735e-65 MirTarget -0.918552583080221 1.08987902824998e-32 NA NA NA hsa-miR-200b-3p CHST2 2.11744072703209 1.66710572104191e-43 -0.894882854431295 9.62306233410265e-12 TargetScan -0.123073817043257 1.20850921730603e-05 NA NA NA hsa-miR-200c-3p CHST2 2.07038651806183 6.84613386286599e-51 -0.894882854431295 9.62306233410265e-12 miRNATAP -0.176242768894039 1.05560685819567e-08 NA NA NA hsa-miR-200b-3p CHST9 2.11744072703209 1.66710572104191e-43 -3.48668023282491 1.2009377943548e-28 TargetScan -0.153842615392145 0.0259139501805727 NA NA NA hsa-miR-200b-3p CHSY3 2.11744072703209 1.66710572104191e-43 0.306225149612841 0.00899058774478209 TargetScan -0.199745631127982 3.1589862956474e-16 NA NA NA hsa-miR-143-3p CIT -1.23248181631499 4.74160976678504e-28 2.04718869890754 1.61616226629049e-61 miRNATAP -0.328468638677981 2.69104404592368e-17 NA NA NA hsa-miR-132-3p CITED2 -0.0365213889238607 0.668598301088667 -0.834044357426571 4.4609160487977e-15 miRNATAP -0.193317870584931 9.45614264946306e-06 NA NA NA hsa-miR-200b-3p CITED2 2.11744072703209 1.66710572104191e-43 -0.834044357426571 4.4609160487977e-15 TargetScan -0.111145966106192 1.13080439681397e-06 NA NA NA hsa-miR-200c-3p CITED2 2.07038651806183 6.84613386286599e-51 -0.834044357426571 4.4609160487977e-15 miRNATAP -0.130545886780671 1.94917710455014e-07 NA NA NA hsa-miR-28-5p CLASP2 -0.14267073663385 0.0497619246260571 -0.480530283040537 1.81219003638834e-11 miRanda -0.162061212588336 2.27538557457813e-06 NA NA NA hsa-miR-141-3p CLCN6 2.99777540204168 1.26370498493024e-78 -1.07256558516376 2.54953953731211e-64 MirTarget -0.187515408739221 1.10347614148443e-50 NA NA NA hsa-miR-200a-3p CLCN6 2.55218480823434 2.96135446816238e-51 -1.07256558516376 2.54953953731211e-64 MirTarget -0.113063803690566 1.11238114512559e-18 NA NA NA hsa-let-7e-5p CLDN1 0.261471269338985 0.00191077095550257 -0.276713557837169 0.180196698823412 MirTarget -0.192794844004822 0.0225324982694245 NA NA NA hsa-miR-145-5p CLDN9 -2.62703571936687 7.64402900188551e-88 1.64165748779949 3.68664643181565e-16 MirTarget -0.320357694047292 1.09177103573848e-11 NA NA NA hsa-miR-141-3p CLIC4 2.99777540204168 1.26370498493024e-78 -0.604325972745405 4.39590515801355e-12 MirTarget -0.131054810035266 9.34162799392801e-15 NA NA NA hsa-miR-200a-3p CLIC4 2.55218480823434 2.96135446816238e-51 -0.604325972745405 4.39590515801355e-12 MirTarget -0.114588073259131 6.01582269497717e-12 NA NA NA hsa-miR-200b-3p CLIC4 2.11744072703209 1.66710572104191e-43 -0.604325972745405 4.39590515801355e-12 MirTarget;TargetScan -0.129255066502504 2.95832614236725e-12 NA NA NA hsa-miR-200c-3p CLIC4 2.07038651806183 6.84613386286599e-51 -0.604325972745405 4.39590515801355e-12 MirTarget;miRNATAP -0.154596823858339 2.69440260316856e-14 NA NA NA hsa-miR-200c-3p CLIP2 2.07038651806183 6.84613386286599e-51 -0.0838401200209011 0.328928067723523 MirTarget;miRNATAP -0.121175791833096 9.84176257133331e-10 NA NA NA hsa-miR-141-3p CLN8 2.99777540204168 1.26370498493024e-78 -0.548479642156373 3.86536491552494e-14 mirMAP -0.113504362082432 6.81558332072343e-16 NA NA NA hsa-miR-200a-3p CLN8 2.55218480823434 2.96135446816238e-51 -0.548479642156373 3.86536491552494e-14 mirMAP -0.101402440654349 2.34966650749595e-13 NA NA NA hsa-miR-200b-3p CLOCK 2.11744072703209 1.66710572104191e-43 -0.444410941110669 0.00108938309187277 MirTarget;TargetScan -0.104862943483691 0.000281770903559823 NA NA NA hsa-miR-143-3p CLSPN -1.23248181631499 4.74160976678504e-28 2.90728456233225 5.53275112524543e-48 MirTarget -0.447564314447778 5.21637507216525e-13 NA NA NA hsa-miR-141-3p CLYBL 2.99777540204168 1.26370498493024e-78 -0.878691118021466 1.98105321641431e-17 mirMAP -0.125666097016546 6.30213828560257e-10 NA NA NA hsa-miR-145-5p CNDP2 -2.62703571936687 7.64402900188551e-88 0.621184844531254 3.98272801079302e-22 MirTarget -0.106594291962046 1.68877714907214e-12 NA NA NA hsa-miR-28-5p CNKSR1 -0.14267073663385 0.0497619246260571 1.44823291536679 2.12293533329982e-27 miRanda -0.136690806427665 0.0378724954718156 NA NA NA hsa-miR-200b-3p CNN3 2.11744072703209 1.66710572104191e-43 -0.430464499015071 9.32927212002364e-06 MirTarget;TargetScan -0.114275940199066 2.67775221206774e-08 NA NA NA hsa-miR-200c-3p CNN3 2.07038651806183 6.84613386286599e-51 -0.430464499015071 9.32927212002364e-06 MirTarget;miRNATAP -0.159482264721371 1.26165223474504e-12 NA NA NA hsa-miR-200b-3p CNTFR 2.11744072703209 1.66710572104191e-43 -4.18061105410292 1.90682468942591e-39 TargetScan -0.554791324000155 1.82863912924816e-15 NA NA NA hsa-miR-200c-3p CNTFR 2.07038651806183 6.84613386286599e-51 -4.18061105410292 1.90682468942591e-39 miRNATAP -0.651234543642083 1.71163355931122e-17 NA NA NA hsa-miR-141-3p CNTN1 2.99777540204168 1.26370498493024e-78 -2.29693171558319 8.43646057960019e-19 MirTarget;TargetScan;miRNATAP -0.520810849287513 2.4730276902971e-25 NA NA NA hsa-miR-200a-3p CNTN1 2.55218480823434 2.96135446816238e-51 -2.29693171558319 8.43646057960019e-19 MirTarget;miRNATAP -0.448173424296059 1.39139352339811e-19 NA NA NA hsa-miR-200b-3p CNTN1 2.11744072703209 1.66710572104191e-43 -2.29693171558319 8.43646057960019e-19 MirTarget -0.443481986404126 1.12213776002377e-15 NA NA NA hsa-miR-200c-3p CNTN1 2.07038651806183 6.84613386286599e-51 -2.29693171558319 8.43646057960019e-19 MirTarget;miRNATAP -0.486655215389096 1.29219201353698e-15 NA NA NA hsa-miR-200b-3p CNTN4 2.11744072703209 1.66710572104191e-43 -1.67531059692434 2.00125518995555e-14 TargetScan -0.262665574307442 2.1312394950109e-08 NA NA NA hsa-miR-200c-3p CNTN4 2.07038651806183 6.84613386286599e-51 -1.67531059692434 2.00125518995555e-14 miRNATAP -0.354167231970875 5.17596993122049e-12 NA NA NA hsa-miR-143-3p COL11A1 -1.23248181631499 4.74160976678504e-28 5.98557038029313 1.10741703125517e-74 MirTarget -0.659991155080745 4.02698262970475e-10 NA NA NA hsa-miR-141-3p COL15A1 2.99777540204168 1.26370498493024e-78 -0.803401987255061 2.68368384262364e-13 MirTarget -0.283251109809767 3.53569331248087e-43 NA NA NA hsa-miR-200a-3p COL15A1 2.55218480823434 2.96135446816238e-51 -0.803401987255061 2.68368384262364e-13 MirTarget -0.239541084377907 1.33609062706718e-31 NA NA NA hsa-miR-143-3p COL24A1 -1.23248181631499 4.74160976678504e-28 1.47685507725844 1.03401062268437e-26 MirTarget -0.141303152288694 0.000802706041060712 NA NA NA hsa-miR-28-5p COL3A1 -0.14267073663385 0.0497619246260571 1.50470077229731 1.9069386527602e-18 miRanda -0.217177944731906 0.00939470887863092 NA NA NA hsa-miR-200b-3p COL4A3 2.11744072703209 1.66710572104191e-43 -2.06982209902333 2.89268812766655e-17 TargetScan -0.138361560009036 0.00908463546638511 NA NA NA hsa-miR-200c-3p COL4A3 2.07038651806183 6.84613386286599e-51 -2.06982209902333 2.89268812766655e-17 miRNATAP -0.114703755043262 0.0494045001394077 NA NA NA hsa-miR-200b-3p COL4A3BP 2.11744072703209 1.66710572104191e-43 -1.01912082714167 3.26023326678508e-38 MirTarget;TargetScan -0.178803495723155 7.28179874882863e-26 NA NA NA hsa-miR-200c-3p COL4A3BP 2.07038651806183 6.84613386286599e-51 -1.01912082714167 3.26023326678508e-38 MirTarget -0.216917715845884 1.44515846406771e-31 NA NA NA hsa-miR-28-5p COL6A3 -0.14267073663385 0.0497619246260571 0.634653480531805 2.31261246968383e-05 miRanda -0.142973027863578 0.0465166725475489 NA NA NA hsa-miR-141-3p COL8A1 2.99777540204168 1.26370498493024e-78 0.811494509913119 3.40026721855729e-06 mirMAP -0.153417512297445 6.50997102751889e-06 NA NA NA hsa-miR-200a-3p COL8A1 2.55218480823434 2.96135446816238e-51 0.811494509913119 3.40026721855729e-06 mirMAP -0.161874172718556 1.21029470085196e-06 NA NA NA hsa-miR-28-5p COMMD3 -0.14267073663385 0.0497619246260571 0.675388089068306 6.93374609568002e-19 miRanda -0.134682275248439 0.000267418960162858 NA NA NA hsa-miR-145-5p COMMD5 -2.62703571936687 7.64402900188551e-88 1.01520256885491 1.90507768979168e-40 MirTarget -0.221115148996679 2.66445262645184e-35 NA NA NA hsa-miR-28-5p COPG2 -0.14267073663385 0.0497619246260571 0.248679199189896 0.000341940906197054 PITA;miRanda -0.181006340148697 3.74563245844575e-08 NA NA NA hsa-miR-141-3p CORO1C 2.99777540204168 1.26370498493024e-78 -0.57046570422146 8.71993218248989e-15 TargetScan -0.133452343069201 4.81951215741389e-21 NA NA NA hsa-miR-200b-3p CORO1C 2.11744072703209 1.66710572104191e-43 -0.57046570422146 8.71993218248989e-15 MirTarget;TargetScan -0.168053875264079 5.76235963121156e-28 NA NA NA hsa-miR-200c-3p CORO1C 2.07038651806183 6.84613386286599e-51 -0.57046570422146 8.71993218248989e-15 MirTarget;miRNATAP -0.174250149922637 7.44833485989281e-25 NA NA NA hsa-let-7e-5p CPA4 0.261471269338985 0.00191077095550257 -0.347650234368286 0.177734787193064 MirTarget;miRNATAP -0.305491770267937 0.0037797118736163 NA NA NA hsa-miR-28-5p CPD -0.14267073663385 0.0497619246260571 -0.241449324374273 0.0207834781120828 PITA;miRanda -0.259823794381588 1.4995780268069e-07 NA NA NA hsa-miR-28-5p CRADD -0.14267073663385 0.0497619246260571 -0.251683647119455 0.000231223686713744 miRanda -0.235221289528442 2.61428453267022e-13 NA NA NA hsa-let-7e-5p CRB2 0.261471269338985 0.00191077095550257 -2.19518094541831 2.07086175228115e-27 miRNATAP -0.20777233925601 0.0152938853931436 NA NA NA hsa-let-7e-5p CREB3L2 0.261471269338985 0.00191077095550257 -0.451029929545694 1.56006948492969e-06 mirMAP -0.121467436652324 0.001643364104474 NA NA NA hsa-miR-141-3p CREB5 2.99777540204168 1.26370498493024e-78 -2.34983683376521 9.5898827522032e-62 mirMAP -0.420728186922246 3.61586637494311e-51 NA NA NA hsa-miR-200a-3p CREB5 2.55218480823434 2.96135446816238e-51 -2.34983683376521 9.5898827522032e-62 mirMAP -0.329840324236737 9.82195063284642e-32 NA NA NA hsa-miR-200b-3p CREB5 2.11744072703209 1.66710572104191e-43 -2.34983683376521 9.5898827522032e-62 TargetScan -0.364418430782804 2.65438137279006e-31 NA NA NA hsa-miR-200c-3p CREB5 2.07038651806183 6.84613386286599e-51 -2.34983683376521 9.5898827522032e-62 miRNATAP -0.482139236249271 2.9707359635911e-46 NA NA NA hsa-miR-28-5p CREBL2 -0.14267073663385 0.0497619246260571 -0.828924810318552 7.72831390224407e-35 miRanda -0.118954483680499 0.000365495180109717 NA NA NA hsa-miR-200b-3p CRHBP 2.11744072703209 1.66710572104191e-43 -3.66581217736436 6.35220493058743e-83 MirTarget -0.59409091405194 1.28495550342245e-44 NA NA NA hsa-miR-200c-3p CRHBP 2.07038651806183 6.84613386286599e-51 -3.66581217736436 6.35220493058743e-83 MirTarget -0.750667430746763 9.48311945356719e-61 NA NA NA hsa-miR-141-3p CRMP1 2.99777540204168 1.26370498493024e-78 -0.337869523464731 0.012350492740263 MirTarget;TargetScan -0.128583387083388 8.74536586439782e-07 NA NA NA hsa-miR-28-5p CROT -0.14267073663385 0.0497619246260571 0.037293899986957 0.777067375226551 MirTarget;miRanda -0.437819717941343 1.51683811218234e-12 NA NA NA hsa-let-7e-5p CRTAM 0.261471269338985 0.00191077095550257 0.682316318769356 0.000113696514388557 MirTarget -0.182901080282964 0.0117725738124273 NA NA NA hsa-miR-200b-3p CRTAP 2.11744072703209 1.66710572104191e-43 -0.981682928574237 1.61266249905263e-58 TargetScan -0.229725630746709 1.15487150061672e-73 NA NA NA hsa-miR-28-5p CRY2 -0.14267073663385 0.0497619246260571 -1.19975346543936 7.77211531373058e-53 miRanda -0.215089887065039 5.72190749767741e-08 NA NA NA hsa-miR-141-3p CRYBG3 2.99777540204168 1.26370498493024e-78 -2.30356586227424 2.15606739484442e-47 MirTarget -0.442346327650811 5.16748105687821e-46 NA NA NA hsa-miR-200a-3p CRYBG3 2.55218480823434 2.96135446816238e-51 -2.30356586227424 2.15606739484442e-47 MirTarget -0.377237192803923 3.61747279589422e-34 NA NA NA hsa-miR-200c-3p CRYBG3 2.07038651806183 6.84613386286599e-51 -2.30356586227424 2.15606739484442e-47 miRNATAP -0.489778998387332 9.99423588006057e-39 NA NA NA hsa-miR-141-3p CSF3 2.99777540204168 1.26370498493024e-78 -3.88687956855714 5.79181068171002e-45 TargetScan;miRNATAP -0.635639647527127 3.84247648434209e-31 NA NA NA hsa-miR-200a-3p CSF3 2.55218480823434 2.96135446816238e-51 -3.88687956855714 5.79181068171002e-45 miRNATAP -0.476735635349525 2.71347727473529e-18 NA NA NA hsa-miR-143-3p CSNK2A1 -1.23248181631499 4.74160976678504e-28 0.308188225977895 5.2689466399312e-07 MirTarget -0.102863413291093 1.39184437094928e-08 NA NA NA hsa-miR-200b-3p CSRNP3 2.11744072703209 1.66710572104191e-43 -3.01553219063623 2.41616502431045e-41 MirTarget;TargetScan -0.390351341608898 2.18846471132251e-15 NA NA NA hsa-miR-200c-3p CSRNP3 2.07038651806183 6.84613386286599e-51 -3.01553219063623 2.41616502431045e-41 MirTarget;miRNATAP -0.418435034601253 1.13548933902e-14 NA NA NA hsa-miR-132-3p CST9L -0.0365213889238607 0.668598301088667 0.900727643330873 0.00141190357480774 miRNAWalker2_validate -0.256074331330126 0.0254955857615731 NA NA NA hsa-miR-141-3p CSTA 2.99777540204168 1.26370498493024e-78 -1.16695336107157 1.13881557219886e-09 MirTarget -0.167586821932582 7.87345552949921e-06 NA NA NA hsa-miR-200a-3p CSTA 2.55218480823434 2.96135446816238e-51 -1.16695336107157 1.13881557219886e-09 MirTarget -0.216364868104157 3.49938925677905e-09 NA NA NA hsa-miR-145-5p CSTF3 -2.62703571936687 7.64402900188551e-88 0.654464844781528 1.22382817704603e-33 MirTarget -0.13081355557103 7.26808258897427e-25 NA NA NA hsa-miR-141-3p CTTNBP2 2.99777540204168 1.26370498493024e-78 -2.41132364496224 1.70068651679973e-31 miRNATAP -0.48438604285692 1.34201756495466e-33 NA NA NA hsa-miR-200a-3p CTTNBP2 2.55218480823434 2.96135446816238e-51 -2.41132364496224 1.70068651679973e-31 miRNATAP -0.417595545099797 8.02479077177629e-26 NA NA NA hsa-miR-200b-3p CUTC 2.11744072703209 1.66710572104191e-43 -0.853774255373969 9.05123514016953e-44 MirTarget -0.139802015777313 1.2310536389459e-25 NA NA NA hsa-miR-200c-3p CUTC 2.07038651806183 6.84613386286599e-51 -0.853774255373969 9.05123514016953e-44 MirTarget -0.151619219375088 6.14895659894412e-25 NA NA NA hsa-miR-28-5p CUX1 -0.14267073663385 0.0497619246260571 0.251301771607609 0.000694928817797916 mirMAP -0.253288444708047 3.74225695287942e-13 NA NA NA hsa-miR-141-3p CXCL12 2.99777540204168 1.26370498493024e-78 -2.12095060237474 3.84001932998671e-54 miRNATAP -0.448767864284497 1.69254754152554e-65 NA NA NA hsa-miR-200a-3p CXCL12 2.55218480823434 2.96135446816238e-51 -2.12095060237474 3.84001932998671e-54 miRNATAP -0.360989618953587 4.22159254970216e-42 NA NA NA hsa-miR-143-3p CYFIP2 -1.23248181631499 4.74160976678504e-28 0.976813641105432 2.04991499001387e-10 MirTarget -0.17553608464588 0.000130259698106616 NA NA NA hsa-miR-200b-3p CYP1B1 2.11744072703209 1.66710572104191e-43 -0.366349924852417 0.0219371555678365 TargetScan -0.170429488545407 4.45723402410594e-07 NA NA NA hsa-miR-200c-3p CYP1B1 2.07038651806183 6.84613386286599e-51 -0.366349924852417 0.0219371555678365 miRNATAP -0.131482636782662 0.000418466827494499 25860934 Loss of miR 200c up regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma; Additionally miR-200c which is significantly down-regulated in RCC regulates CYP1B1 expression and activity; An inverse association was also observed between the expression levels of miR-200c and CYP1B1 protein in RCC tissues; Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c; These results suggest that CYP1B1 up-regulation mediated by low miR-200c is one of the mechanisms underlying resistance of RCC cells to docetaxel; Therefore expression of CYP1B1 and miR-200c in RCC may be useful as a prediction for docetaxel response drug resistance kidney renal cell cancer hsa-miR-141-3p CYP26B1 2.99777540204168 1.26370498493024e-78 -2.18251820929743 2.06650075366595e-36 MirTarget;TargetScan;miRNATAP -0.468193892142109 8.8877242775259e-45 NA NA NA hsa-miR-200a-3p CYP26B1 2.55218480823434 2.96135446816238e-51 -2.18251820929743 2.06650075366595e-36 MirTarget;miRNATAP -0.395715664654096 1.11650580193469e-32 NA NA NA hsa-miR-28-5p CYTH2 -0.14267073663385 0.0497619246260571 0.702575167222823 2.04335535926724e-21 MirTarget;miRanda;miRNATAP -0.196402252030897 4.26017752822191e-08 NA NA NA hsa-miR-200b-3p CYTH3 2.11744072703209 1.66710572104191e-43 -0.739339936855419 6.60636378987249e-16 MirTarget;TargetScan -0.179688735229407 1.31004009391563e-20 NA NA NA hsa-miR-200c-3p CYTH3 2.07038651806183 6.84613386286599e-51 -0.739339936855419 6.60636378987249e-16 MirTarget -0.231010764393206 4.28100692899043e-28 NA NA NA hsa-miR-141-3p DAB1 2.99777540204168 1.26370498493024e-78 -0.432897540232205 0.0630097305913186 TargetScan -0.129815823459169 0.0041406560740659 NA NA NA hsa-miR-200b-3p DACT1 2.11744072703209 1.66710572104191e-43 0.215644957293964 0.116094250345454 TargetScan -0.171152597035203 3.05124361992579e-09 NA NA NA hsa-miR-200c-3p DACT1 2.07038651806183 6.84613386286599e-51 0.215644957293964 0.116094250345454 miRNATAP -0.214743266019268 1.14926241164992e-11 NA NA NA hsa-miR-28-5p DALRD3 -0.14267073663385 0.0497619246260571 0.592133186684577 7.32758102420887e-12 miRanda -0.448285991408448 8.89585675977247e-29 NA NA NA hsa-miR-132-3p DAZAP2 -0.0365213889238607 0.668598301088667 0.0462419874292657 0.329536160227049 MirTarget;miRNATAP -0.163274109078605 2.88538308402297e-18 NA NA NA hsa-miR-28-5p DAZAP2 -0.14267073663385 0.0497619246260571 0.0462419874292657 0.329536160227049 miRanda -0.167753753611657 3.68313522146614e-14 NA NA NA hsa-miR-28-5p DCAF10 -0.14267073663385 0.0497619246260571 0.606966187301492 2.00839543145119e-08 MirTarget -0.196082350894576 0.000155061231870187 NA NA NA hsa-miR-200b-3p DCBLD2 2.11744072703209 1.66710572104191e-43 -0.917133394406548 5.34724051251788e-23 MirTarget;TargetScan -0.162742843767685 2.77976107416141e-16 NA NA NA hsa-miR-200c-3p DCBLD2 2.07038651806183 6.84613386286599e-51 -0.917133394406548 5.34724051251788e-23 MirTarget -0.214264937800917 4.83838631904915e-23 NA NA NA hsa-miR-141-3p DCUN1D3 2.99777540204168 1.26370498493024e-78 -1.06136698889532 1.78469564912163e-54 MirTarget;TargetScan -0.200266235728814 5.13180996799693e-51 NA NA NA hsa-miR-200a-3p DCUN1D3 2.55218480823434 2.96135446816238e-51 -1.06136698889532 1.78469564912163e-54 MirTarget -0.162885585039659 3.80601915743393e-34 NA NA NA hsa-miR-200b-3p DCUN1D3 2.11744072703209 1.66710572104191e-43 -1.06136698889532 1.78469564912163e-54 TargetScan -0.181182787572894 3.74582101862922e-34 NA NA NA hsa-miR-141-3p DCX 2.99777540204168 1.26370498493024e-78 -2.74666176017894 1.23860367619362e-14 TargetScan -0.209405150885142 0.00293185473310962 NA NA NA hsa-miR-141-3p DDI2 2.99777540204168 1.26370498493024e-78 -0.874948299770357 1.36141202726123e-06 mirMAP -0.12916978300103 0.000259964174752733 NA NA NA hsa-miR-200a-3p DDI2 2.55218480823434 2.96135446816238e-51 -0.874948299770357 1.36141202726123e-06 mirMAP -0.120570867690186 0.000513750730903842 NA NA NA hsa-miR-200b-3p DDIT4L 2.11744072703209 1.66710572104191e-43 -1.72136204540736 8.31023692335201e-21 MirTarget -0.293176758879881 1.08353405270708e-13 NA NA NA hsa-miR-200c-3p DDIT4L 2.07038651806183 6.84613386286599e-51 -1.72136204540736 8.31023692335201e-21 MirTarget -0.40326983794807 6.35694817505525e-21 NA NA NA hsa-miR-145-5p DDX54 -2.62703571936687 7.64402900188551e-88 0.629454563561322 1.70149353018142e-17 MirTarget -0.172306414523893 4.54928157008099e-24 NA NA NA hsa-miR-28-5p DDX60 -0.14267073663385 0.0497619246260571 0.258448146031201 0.049511423209945 miRanda -0.124121210231133 0.0479397801929396 NA NA NA hsa-miR-200b-3p DENND2C 2.11744072703209 1.66710572104191e-43 -1.73921300700411 1.51303781815381e-36 TargetScan -0.265074951195699 8.66219250243038e-19 NA NA NA hsa-miR-200b-3p DENND5A 2.11744072703209 1.66710572104191e-43 -0.764375256872762 3.88256445865292e-35 MirTarget;TargetScan -0.153299012636592 2.43551549311115e-31 NA NA NA hsa-miR-200c-3p DENND5A 2.07038651806183 6.84613386286599e-51 -0.764375256872762 3.88256445865292e-35 MirTarget -0.181507369639065 1.55183408062696e-36 NA NA NA hsa-miR-200b-3p DENND5B 2.11744072703209 1.66710572104191e-43 -1.14155413410849 4.38267204750606e-22 MirTarget;TargetScan;mirMAP -0.214271306079196 2.10933160432161e-17 NA NA NA hsa-miR-200c-3p DENND5B 2.07038651806183 6.84613386286599e-51 -1.14155413410849 4.38267204750606e-22 MirTarget;miRNATAP -0.264064948748841 1.10818038269175e-21 NA NA NA hsa-let-7e-5p DERL3 0.261471269338985 0.00191077095550257 1.13325735405579 4.84930415183079e-11 mirMAP -0.140894389319641 0.0485424814384391 NA NA NA hsa-miR-200b-3p DGKH 2.11744072703209 1.66710572104191e-43 -0.547048774392132 6.50624877314515e-05 TargetScan -0.103304616156979 0.000389266335387264 NA NA NA hsa-miR-28-5p DHRS2 -0.14267073663385 0.0497619246260571 1.07976211540207 0.0180138769274907 miRanda -1.42153982969568 4.1358623924697e-11 NA NA NA hsa-miR-28-5p DHRS4 -0.14267073663385 0.0497619246260571 0.0781364876424782 0.360324485265141 miRanda -0.252257675076986 3.65800347648958e-10 NA NA NA hsa-miR-28-5p DHRS4L1 -0.14267073663385 0.0497619246260571 -0.0991231860873832 0.44302544820008 miRanda -0.346024158096003 1.45044398203217e-08 NA NA NA hsa-miR-28-5p DHRS4L2 -0.14267073663385 0.0497619246260571 -0.0131580653571994 0.885661344969612 miRanda -0.240307182431194 2.6902141983072e-08 NA NA NA hsa-miR-28-5p DHRS7B -0.14267073663385 0.0497619246260571 -0.227646059774749 0.0024852530623363 miRanda;miRNATAP -0.196022437875585 3.73712774456641e-08 NA NA NA hsa-miR-28-5p DHX29 -0.14267073663385 0.0497619246260571 0.0734426982923981 0.254121869868459 miRanda -0.227299174298341 4.81576551681987e-14 NA NA NA hsa-miR-28-5p DHX58 -0.14267073663385 0.0497619246260571 0.568647882524633 8.82962162841857e-09 miRanda -0.196598808324417 3.29420558267845e-05 NA NA NA hsa-miR-200b-3p DIAPH2 2.11744072703209 1.66710572104191e-43 -1.20202712880697 5.09928447049557e-26 mirMAP -0.258157766848499 1.27409512267861e-26 NA NA NA hsa-miR-200c-3p DIAPH2 2.07038651806183 6.84613386286599e-51 -1.20202712880697 5.09928447049557e-26 mirMAP -0.227851956411517 2.52808083431139e-17 NA NA NA hsa-miR-200b-3p DIRAS2 2.11744072703209 1.66710572104191e-43 -2.10620497339661 3.78327238934435e-17 TargetScan -0.123216826999439 0.0229710931633841 NA NA NA hsa-miR-200b-3p DIXDC1 2.11744072703209 1.66710572104191e-43 -1.64219180882631 5.60950919042518e-55 MirTarget;TargetScan -0.225258063725434 4.24903178671413e-22 NA NA NA hsa-miR-200c-3p DIXDC1 2.07038651806183 6.84613386286599e-51 -1.64219180882631 5.60950919042518e-55 MirTarget -0.322709555114611 8.03840245468509e-38 NA NA NA hsa-miR-141-3p DLC1 2.99777540204168 1.26370498493024e-78 -1.8530731128301 3.51319109988247e-52 TargetScan;miRNATAP -0.432741868485591 1.2910764674069e-79 26278151 MicroRNA 141 regulates the tumour suppressor DLC1 in colorectal cancer; Luciferase reporter assays and Western blots showed that DLC1 was a direct target of miR-141 in CRC; The expression levels of miR-141 were obviously up-regulated in CRC tissues compared to non-cancerous tissues while DLC1 expression levels were down-regulated in a high proportion of clinical samples 14/18; In addition correlation analyses revealed negative correlation between miR-141 levels and DLC1 expression levels in CRC tissues; In conclusion we demonstrated that miR-141 is up-regulated in CRC and acts as a functional oncogene by targeting DLC1 colorectal cancer hsa-miR-200a-3p DLC1 2.55218480823434 2.96135446816238e-51 -1.8530731128301 3.51319109988247e-52 miRNATAP -0.334475150411796 3.98164233713817e-46 NA NA NA hsa-miR-200b-3p DLC1 2.11744072703209 1.66710572104191e-43 -1.8530731128301 3.51319109988247e-52 TargetScan -0.353191572353844 3.03754552853308e-41 NA NA NA hsa-miR-200c-3p DLC1 2.07038651806183 6.84613386286599e-51 -1.8530731128301 3.51319109988247e-52 miRNATAP -0.447999246169696 2.11821437588801e-56 NA NA NA hsa-miR-28-5p DLG2 -0.14267073663385 0.0497619246260571 -1.70773493423543 2.1905000054968e-26 mirMAP -0.214588108952097 0.00663126365203248 NA NA NA hsa-miR-143-3p DLG3 -1.23248181631499 4.74160976678504e-28 1.21494513802964 2.93461327640254e-55 MirTarget;miRNATAP -0.243406102585405 2.48340082004429e-24 NA NA NA hsa-miR-145-5p DLG3 -2.62703571936687 7.64402900188551e-88 1.21494513802964 2.93461327640254e-55 mirMAP -0.237061088767399 8.12285382637334e-38 NA NA NA hsa-let-7e-5p DMD 0.261471269338985 0.00191077095550257 -3.78348112804436 3.23742415858975e-92 MirTarget;miRNATAP -0.431019859928948 3.89592095969677e-07 NA NA NA hsa-miR-200b-3p DMD 2.11744072703209 1.66710572104191e-43 -3.78348112804436 3.23742415858975e-92 TargetScan -0.510427905772079 3.88526815872611e-33 NA NA NA hsa-miR-200c-3p DMD 2.07038651806183 6.84613386286599e-51 -3.78348112804436 3.23742415858975e-92 miRNATAP -0.594316988497947 2.4582438776106e-37 NA NA NA hsa-miR-200b-3p DMRT2 2.11744072703209 1.66710572104191e-43 -3.08901844202474 2.98127356930882e-47 TargetScan -0.420966708091852 4.44598672992894e-19 NA NA NA hsa-miR-200c-3p DMRT2 2.07038651806183 6.84613386286599e-51 -3.08901844202474 2.98127356930882e-47 miRNATAP -0.571609657439647 5.99062402490001e-29 NA NA NA hsa-miR-141-3p DMXL1 2.99777540204168 1.26370498493024e-78 -0.887801034869518 5.15580975471564e-22 TargetScan;miRNATAP -0.128764608054307 1.21907781714685e-12 NA NA NA hsa-miR-200a-3p DMXL1 2.55218480823434 2.96135446816238e-51 -0.887801034869518 5.15580975471564e-22 miRNATAP -0.116891641367755 5.44879226015795e-11 NA NA NA hsa-let-7e-5p DNAH3 0.261471269338985 0.00191077095550257 0.332744337992025 0.209502737233074 mirMAP -0.226244658405473 0.0371493593077057 NA NA NA hsa-miR-28-5p DNAJA4 -0.14267073663385 0.0497619246260571 0.778974960199304 3.35701271270575e-11 miRanda;miRNATAP -0.367555686579116 5.42936568736381e-11 NA NA NA hsa-miR-145-5p DNAJB11 -2.62703571936687 7.64402900188551e-88 0.846821507539959 1.07498028457879e-32 miRNATAP -0.135628478361593 9.80935096514868e-16 NA NA NA hsa-miR-28-5p DNAJB14 -0.14267073663385 0.0497619246260571 -0.389536819121818 1.15940870921076e-05 miRanda -0.130292186583654 0.00214996577325443 NA NA NA hsa-miR-200b-3p DNAJB5 2.11744072703209 1.66710572104191e-43 -0.230804626842819 0.00593901558381227 TargetScan -0.16209690885105 1.16618877334719e-20 NA NA NA hsa-miR-200c-3p DNAJB5 2.07038651806183 6.84613386286599e-51 -0.230804626842819 0.00593901558381227 miRNATAP -0.223752498175136 1.42531019142238e-32 NA NA NA hsa-miR-28-5p DNAJC12 -0.14267073663385 0.0497619246260571 1.43850602777815 2.34358351695651e-08 miRanda -1.08463819946357 3.47364266841502e-19 NA NA NA hsa-miR-200b-3p DNAJC18 2.11744072703209 1.66710572104191e-43 -1.21097498295448 1.75696643911026e-57 TargetScan -0.168564361181547 1.09723433937693e-23 NA NA NA hsa-miR-200b-3p DNM3 2.11744072703209 1.66710572104191e-43 -0.810737959701514 9.66102375905489e-13 mirMAP -0.205135096397742 1.14692669079158e-17 NA NA NA hsa-miR-132-3p DNMBP -0.0365213889238607 0.668598301088667 -0.666936518001947 1.27257555078449e-08 MirTarget -0.105793714504863 0.0272187631746816 NA NA NA hsa-miR-28-5p DNMBP -0.14267073663385 0.0497619246260571 -0.666936518001947 1.27257555078449e-08 miRanda -0.284585338956239 3.74226293978231e-07 NA NA NA hsa-miR-143-3p DNMT3A -1.23248181631499 4.74160976678504e-28 0.954713787765479 1.01650948201553e-39 miRNAWalker2_validate;miRTarBase;miRNATAP -0.134719476301317 1.50584906913356e-09 24218337;19638978 Ectopic expression of miR-143 inhibited proliferation and soft agar colony formation of breast cancer cells and also downregulated DNA methyltransferase 3A DNMT3A expression on both mRNA and protein levels; DNMT3A was demonstrated to be a direct target of miR-143 by luciferase reporter assay; Furthermore miR-143 expression was observed to be inversely correlated with DNMT3A mRNA and protein expression in breast cancer tissues; Our findings suggest that miR-143 regulates DNMT3A in breast cancer cells;Using in silico predictions DNA methyltranferase 3A DNMT3A was defined as a potential target of miR-143; Restoration of the miR-143 expression in colon cell lines decreased tumour cell growth and soft-agar colony formation and downregulated the DNMT3A expression in both mRNA and protein levels; DNMT3A was shown to be a direct target of miR-143 by luciferase reporter assay; Furthermore the miR-143 expression was observed to be inversely correlated with DNMT3A mRNA and protein expression in CRC tissues; Our findings suggest that miR-143 regulates DNMT3A in CRC ; breast cancer;colorectal cancer hsa-miR-145-5p DNMT3B -2.62703571936687 7.64402900188551e-88 1.26852514332715 7.89943263342799e-23 MirTarget -0.231984216994308 2.04108386654072e-14 24071015;25749421 In univariate analysis the combination of DNMT3B overexpression and miR-145 or miR-143 down-regulation was more powerful in predicting shorter survival P < .05 than use of the biomarkers individually P > .05; DNMT3B might be a potential target of miR-145 and miR-143 in ECs; Furthermore the combined miR-145 or miR-143 and DNMT3B status may have a prognostic impact on ECs;It was found that miR-145 upregulates while DNMT3b downregulates in PC3 cells; Responses of the miR-145 and DNMT3b to irradiation are a negative correlation; We also found that either overexpression of miR-145 or knockdown of DNMT3b sensitized prostate cancer cells to X-ray radiation poor survival;drug resistance endometrial cancer;prostate cancer hsa-miR-141-3p DOCK4 2.99777540204168 1.26370498493024e-78 -0.955337759049208 3.43382447572213e-22 MirTarget;TargetScan -0.210393690177201 2.03501174940062e-28 NA NA NA hsa-miR-200a-3p DOCK4 2.55218480823434 2.96135446816238e-51 -0.955337759049208 3.43382447572213e-22 MirTarget -0.185565911049899 5.70205349342196e-23 NA NA NA hsa-miR-200b-3p DOCK4 2.11744072703209 1.66710572104191e-43 -0.955337759049208 3.43382447572213e-22 MirTarget;TargetScan -0.206492508003537 5.41609370323406e-23 NA NA NA hsa-miR-200c-3p DOCK4 2.07038651806183 6.84613386286599e-51 -0.955337759049208 3.43382447572213e-22 MirTarget -0.238022407072748 3.03078217292148e-25 NA NA NA hsa-miR-28-5p DPH1 -0.14267073663385 0.0497619246260571 -0.0275786670934695 0.663368667669771 miRanda -0.13551892924721 6.16360587687299e-06 NA NA NA hsa-miR-28-5p DPP3 -0.14267073663385 0.0497619246260571 1.58410857657904 3.35818668883493e-77 miRanda -0.185549722751376 3.15204874454426e-05 NA NA NA hsa-miR-200b-3p DPY19L1 2.11744072703209 1.66710572104191e-43 -0.178318855946124 0.0539793445603746 TargetScan -0.139480581335356 5.89595660847506e-13 NA NA NA hsa-miR-200c-3p DPY19L1 2.07038651806183 6.84613386286599e-51 -0.178318855946124 0.0539793445603746 miRNATAP -0.151975228498484 9.68558203611305e-13 NA NA NA hsa-miR-141-3p DPYSL3 2.99777540204168 1.26370498493024e-78 -0.677451473132496 4.89051442199237e-08 TargetScan -0.288398873329492 3.88589665477977e-35 NA NA NA hsa-miR-28-5p DQX1 -0.14267073663385 0.0497619246260571 3.64196683187679 4.5119403521697e-36 miRanda -0.792329778275761 3.56456901527464e-08 NA NA NA hsa-miR-141-3p DRD2 2.99777540204168 1.26370498493024e-78 -2.9692348889129 3.17984771024914e-29 TargetScan -0.297197318551456 1.99671159115873e-08 NA NA NA hsa-miR-141-3p DSEL 2.99777540204168 1.26370498493024e-78 -1.63646239446313 1.15495842561897e-29 TargetScan -0.366759130124937 8.96976078448598e-40 NA NA NA hsa-let-7e-5p DST 0.261471269338985 0.00191077095550257 -2.65768728199613 1.49859497194328e-82 miRNATAP -0.233405536958562 0.000192215134190498 NA NA NA hsa-miR-141-3p DST 2.99777540204168 1.26370498493024e-78 -2.65768728199613 1.49859497194328e-82 mirMAP -0.3846762141789 4.60517241267005e-42 NA NA NA hsa-miR-200a-3p DST 2.55218480823434 2.96135446816238e-51 -2.65768728199613 1.49859497194328e-82 mirMAP -0.289656110108089 2.18967385872587e-24 NA NA NA hsa-miR-200b-3p DST 2.11744072703209 1.66710572104191e-43 -2.65768728199613 1.49859497194328e-82 mirMAP -0.293585785496736 2.54473459359641e-20 NA NA NA hsa-miR-200c-3p DST 2.07038651806183 6.84613386286599e-51 -2.65768728199613 1.49859497194328e-82 mirMAP -0.367710964272576 2.86982979480575e-26 NA NA NA hsa-miR-200c-3p DTNA 2.07038651806183 6.84613386286599e-51 -0.983895543773159 3.56086232599839e-08 MirTarget -0.138865450327607 0.000930379966235622 NA NA NA hsa-miR-132-3p DTWD2 -0.0365213889238607 0.668598301088667 -0.261106719372882 0.00652226445516583 mirMAP -0.204615328375648 1.20623950497982e-07 NA NA NA hsa-miR-28-5p DTWD2 -0.14267073663385 0.0497619246260571 -0.261106719372882 0.00652226445516583 miRanda -0.319410509963769 1.55805399694254e-12 NA NA NA hsa-let-7e-5p DTX2 0.261471269338985 0.00191077095550257 0.903653228188213 7.9545398293293e-26 miRNATAP -0.1129127230496 0.00183803119587841 NA NA NA hsa-let-7e-5p DTX4 0.261471269338985 0.00191077095550257 -0.808306262548725 7.43344328322145e-09 miRNATAP -0.223193520657395 0.000106139101888444 NA NA NA hsa-miR-141-3p DUSP1 2.99777540204168 1.26370498493024e-78 -2.09516763518402 5.67014496179034e-44 TargetScan -0.440500474854258 4.67394231028638e-52 NA NA NA hsa-miR-200b-3p DUSP1 2.11744072703209 1.66710572104191e-43 -2.09516763518402 5.67014496179034e-44 MirTarget;TargetScan -0.374890795121428 1.11762164968543e-30 NA NA NA hsa-miR-200c-3p DUSP1 2.07038651806183 6.84613386286599e-51 -2.09516763518402 5.67014496179034e-44 MirTarget;miRNATAP -0.461418642771936 8.7350380053437e-39 NA NA NA hsa-miR-141-3p DUSP3 2.99777540204168 1.26370498493024e-78 -0.527416845652245 2.0194487779533e-21 MirTarget;TargetScan;miRNATAP -0.119241384977083 5.00857115800078e-29 NA NA NA hsa-miR-141-3p DYNC1I1 2.99777540204168 1.26370498493024e-78 -1.58158153479423 1.8736425450938e-21 MirTarget -0.289847843772981 4.39467889786326e-19 NA NA NA hsa-miR-200a-3p DYNC1I1 2.55218480823434 2.96135446816238e-51 -1.58158153479423 1.8736425450938e-21 MirTarget -0.246463836286345 1.46650798343151e-14 NA NA NA hsa-miR-200b-3p DYNC1I1 2.11744072703209 1.66710572104191e-43 -1.58158153479423 1.8736425450938e-21 MirTarget -0.241032008294904 1.64139559615372e-11 NA NA NA hsa-miR-200c-3p DYNC1I1 2.07038651806183 6.84613386286599e-51 -1.58158153479423 1.8736425450938e-21 MirTarget -0.305316864468734 6.54309610362217e-15 NA NA NA hsa-miR-28-5p DYNC2LI1 -0.14267073663385 0.0497619246260571 -0.00277231382927301 0.963653940981411 miRanda -0.131841275234267 4.59676931998792e-06 NA NA NA hsa-miR-28-5p DYNLL2 -0.14267073663385 0.0497619246260571 0.0640586851492353 0.385985405743691 miRanda -0.138480243677895 7.74924044116613e-05 NA NA NA hsa-miR-28-5p DYNLRB2 -0.14267073663385 0.0497619246260571 0.0266923189330223 0.906740352238072 miRanda -0.964471145480037 9.91972082004647e-20 NA NA NA hsa-miR-143-3p DYRK1B -1.23248181631499 4.74160976678504e-28 0.581903103773096 2.80467268263234e-10 MirTarget;miRNATAP -0.162275842658575 2.96301297548672e-09 NA NA NA hsa-miR-141-3p DZIP1 2.99777540204168 1.26370498493024e-78 -1.06531126131458 4.72890562161364e-17 TargetScan;miRNATAP -0.227272656148558 2.44758513161233e-20 NA NA NA hsa-miR-200a-3p DZIP1 2.55218480823434 2.96135446816238e-51 -1.06531126131458 4.72890562161364e-17 miRNATAP -0.22303755512996 2.38751463031969e-20 NA NA NA hsa-miR-200b-3p DZIP1 2.11744072703209 1.66710572104191e-43 -1.06531126131458 4.72890562161364e-17 MirTarget;TargetScan -0.235396049192488 2.16145312966316e-18 NA NA NA hsa-miR-200c-3p DZIP1 2.07038651806183 6.84613386286599e-51 -1.06531126131458 4.72890562161364e-17 MirTarget -0.252495119306762 1.54084026295551e-17 NA NA NA hsa-miR-205-5p E2F1 -1.70057043266505 1.20976599540743e-09 2.60062333464716 6.00545189391833e-64 miRNAWalker2_validate;miRTarBase;miRNATAP -0.154229027607252 9.82898858548395e-15 22578566;21454583 Re-expression of miR-205 where absent strongly reduces cell proliferation cell cycle progression and clonogenic potential in vitro and inhibits tumor growth in vivo and this tumor suppressor activity is at least partially exerted through targeting of E2F1 master regulator of cell cycle progression and LAMC1 component of extracellular matrix involved in cell adhesion proliferation and migration;The expression levels of E2F1 and E2F5 were correlated inversely with that of miR-205 in melanoma cell lines; miR-205 significantly suppressed the luciferase activity of reporter plasmids containing the 3'-UTR sequences complementary to either E2F1 or E2F5; Overexpression of miR-205 in melanoma cells reduced E2F1 and E2F5 protein levels progression; breast cancer;melanoma hsa-miR-145-5p E2F3 -2.62703571936687 7.64402900188551e-88 0.722298179791941 1.47364190074422e-14 miRNATAP -0.119587655423822 5.65169736724442e-08 25762621 miR 145 mediates the antiproliferative and gene regulatory effects of vitamin D3 by directly targeting E2F3 in gastric cancer cells; Furthermore miR-145 expression was lower in tumors compared with matched normal samples and correlated with increased the E2F3 transcription factor protein staining gastric cancer hsa-miR-28-5p EDA2R -0.14267073663385 0.0497619246260571 -1.34255111275385 3.98620322593049e-21 miRanda -0.231407177745149 0.000862123744152227 NA NA NA hsa-let-7e-5p EDN1 0.261471269338985 0.00191077095550257 -1.72115310703749 1.9106679470357e-25 MirTarget;miRNATAP -0.233853630222122 0.000777471229946255 NA NA NA hsa-miR-200c-3p EDNRA 2.07038651806183 6.84613386286599e-51 -0.14153486543887 0.241849668080954 miRNAWalker2_validate;miRNATAP -0.2381009935223 7.07311760507522e-18 NA NA NA hsa-let-7e-5p EFHD2 0.261471269338985 0.00191077095550257 0.75695887612236 4.98668233829625e-16 miRNATAP -0.109296856334894 0.00490443913209153 NA NA NA hsa-miR-145-5p EFNA3 -2.62703571936687 7.64402900188551e-88 1.58152606743336 5.43547499348979e-24 miRNATAP -0.225183758775436 1.30937642878182e-09 NA NA NA hsa-miR-200c-3p EFNA5 2.07038651806183 6.84613386286599e-51 -1.37163072863579 4.49535560121869e-12 miRNATAP -0.128934276846316 0.00592726380694451 NA NA NA hsa-miR-200b-3p EFNB2 2.11744072703209 1.66710572104191e-43 -0.897920611264786 1.38298319936521e-15 TargetScan -0.153669839656411 1.61131127652127e-10 NA NA NA hsa-miR-200c-3p EFNB2 2.07038651806183 6.84613386286599e-51 -0.897920611264786 1.38298319936521e-15 miRNATAP -0.186700234716791 1.39840372693239e-12 NA NA NA hsa-miR-28-5p EFR3B -0.14267073663385 0.0497619246260571 0.730193640676275 4.13434721202402e-06 MirTarget;miRNATAP -0.183043473691123 0.0160063314742513 NA NA NA hsa-miR-141-3p EGFR 2.99777540204168 1.26370498493024e-78 -3.35228711557446 2.81857446737209e-45 MirTarget -0.586858650420638 4.17631860777935e-36 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-200a-3p EGFR 2.55218480823434 2.96135446816238e-51 -3.35228711557446 2.81857446737209e-45 MirTarget -0.529702964197266 2.19864859009139e-30 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-28-5p EGLN3 -0.14267073663385 0.0497619246260571 1.25406110119931 1.58374008569191e-13 miRanda -0.214502668135583 0.00907143930411108 NA NA NA hsa-miR-141-3p EGR2 2.99777540204168 1.26370498493024e-78 -2.23233044425839 1.40886014268655e-41 TargetScan;miRNATAP -0.346887219038254 4.29424042861336e-26 NA NA NA hsa-miR-200a-3p EGR2 2.55218480823434 2.96135446816238e-51 -2.23233044425839 1.40886014268655e-41 miRNATAP -0.269145922896662 1.57570976681187e-16 NA NA NA hsa-miR-200b-3p EGR3 2.11744072703209 1.66710572104191e-43 -2.44968774088166 1.03461455370655e-31 TargetScan -0.225044430748795 9.45788374247688e-07 NA NA NA hsa-miR-28-5p EIF2AK1 -0.14267073663385 0.0497619246260571 0.859351234809848 8.38838356282298e-53 miRanda -0.143546463072448 4.26354140335158e-07 NA NA NA hsa-miR-143-3p EIF2AK3 -1.23248181631499 4.74160976678504e-28 0.234505707022076 0.00143236353655894 MirTarget -0.135515454513091 3.39184869026273e-10 NA NA NA hsa-miR-141-3p EIF4E3 2.99777540204168 1.26370498493024e-78 -1.14472452087938 6.75636040536301e-35 mirMAP -0.217157198895305 3.95442611475688e-33 NA NA NA hsa-miR-200a-3p EIF4E3 2.55218480823434 2.96135446816238e-51 -1.14472452087938 6.75636040536301e-35 mirMAP -0.148264190141239 3.35037951163213e-16 NA NA NA hsa-miR-200b-3p EIF4E3 2.11744072703209 1.66710572104191e-43 -1.14472452087938 6.75636040536301e-35 TargetScan -0.163275109385133 6.67952122506921e-16 NA NA NA hsa-miR-28-5p EIF4E3 -0.14267073663385 0.0497619246260571 -1.14472452087938 6.75636040536301e-35 MirTarget;miRanda -0.204829970524929 8.50373422668106e-06 NA NA NA hsa-miR-141-3p EIF4EBP2 2.99777540204168 1.26370498493024e-78 -1.00706941701809 2.99774215783787e-56 TargetScan -0.137389399519544 1.3326057443494e-26 NA NA NA hsa-miR-145-5p ELFN2 -2.62703571936687 7.64402900188551e-88 1.01161197521848 6.69138142173359e-05 mirMAP -0.136585235242268 0.0211028981996716 NA NA NA hsa-miR-205-5p ELFN2 -1.70057043266505 1.20976599540743e-09 1.01161197521848 6.69138142173359e-05 mirMAP -0.148034639546594 1.44006826277993e-06 NA NA NA hsa-miR-28-5p ELFN2 -0.14267073663385 0.0497619246260571 1.01161197521848 6.69138142173359e-05 mirMAP -0.41757118919234 0.000570782553848412 NA NA NA hsa-miR-141-3p ELK3 2.99777540204168 1.26370498493024e-78 -0.902894075580307 3.57638726412939e-16 TargetScan -0.25004057553603 2.04702449975357e-32 NA NA NA hsa-miR-200b-3p ELK3 2.11744072703209 1.66710572104191e-43 -0.902894075580307 3.57638726412939e-16 TargetScan -0.223736974181422 9.26437402081844e-22 NA NA NA hsa-miR-200b-3p ELL2 2.11744072703209 1.66710572104191e-43 -0.464211798623089 6.21722889684294e-06 MirTarget;TargetScan -0.111914987066807 2.73779968442616e-07 NA NA NA hsa-miR-200c-3p ELL2 2.07038651806183 6.84613386286599e-51 -0.464211798623089 6.21722889684294e-06 MirTarget -0.121169417275693 4.18860520613644e-07 NA NA NA hsa-miR-28-5p ELMOD3 -0.14267073663385 0.0497619246260571 -1.18321142026853 1.42445980731353e-54 miRanda -0.129213859015614 0.000848520939567749 NA NA NA hsa-miR-28-5p ELOF1 -0.14267073663385 0.0497619246260571 0.695308488112227 7.67760846517974e-22 mirMAP -0.131078180765713 0.000203074103328385 NA NA NA hsa-miR-200b-3p EMB 2.11744072703209 1.66710572104191e-43 -0.149671804994488 0.294307117637889 TargetScan -0.107030374279729 0.000396055731503279 NA NA NA hsa-miR-143-3p EME1 -1.23248181631499 4.74160976678504e-28 2.43468682006002 2.34071521689393e-60 MirTarget -0.41546623025339 3.80575575801082e-19 NA NA NA hsa-miR-28-5p ENOSF1 -0.14267073663385 0.0497619246260571 -0.0494377033754967 0.530975780572447 miRanda -0.116679544081481 0.00185633881646488 NA NA NA hsa-miR-200b-3p ENPEP 2.11744072703209 1.66710572104191e-43 -0.841847912753876 5.14436160563452e-12 mirMAP -0.262531057191957 6.36435363001191e-25 NA NA NA hsa-miR-28-5p ENPP5 -0.14267073663385 0.0497619246260571 0.730179563987445 0.000250569116717678 miRanda -0.430134462533778 5.87774849114148e-06 NA NA NA hsa-miR-141-3p EPB41L3 2.99777540204168 1.26370498493024e-78 -0.754440114178199 1.08976310012052e-09 miRNATAP -0.193180613266036 6.1248092441496e-16 NA NA NA hsa-miR-200a-3p EPB41L3 2.55218480823434 2.96135446816238e-51 -0.754440114178199 1.08976310012052e-09 miRNATAP -0.175535900400833 8.09800571974403e-14 NA NA NA hsa-miR-28-5p EPB41L4A -0.14267073663385 0.0497619246260571 -0.674310150249758 9.72635451687197e-08 miRanda -0.387849374944374 1.07747570210006e-10 NA NA NA hsa-miR-141-3p EPHA2 2.99777540204168 1.26370498493024e-78 -1.25921912819417 1.34618358519816e-29 MirTarget;TargetScan;miRNATAP -0.184299260927489 6.45342555838155e-17 24647573 miR 141 is a key regulator of renal cell carcinoma proliferation and metastasis by controlling EphA2 expression; In addition a specific and inverse correlation between miR-141 and EphA2 expression was obtained in human ccRCC samples metastasis kidney renal cell cancer hsa-miR-200a-3p EPHA2 2.55218480823434 2.96135446816238e-51 -1.25921912819417 1.34618358519816e-29 MirTarget;miRNATAP -0.119330959159105 5.02146466331342e-08 22562546;26088362;24503464 Our studies propose EphA2 as a novel and important target gene for miR-200a;miR 200a inhibits migration of triple negative breast cancer cells through direct repression of the EPHA2 oncogene; We show that EPHA2 expression is correlated with poor survival specifically in basal-like breast cancer and that its expression is repressed by miR-200a through direct interaction with the 3'UTR of EPHA2; We establish that miR-200a directs cell migration in a dual manner; in addition to regulating the well-characterized E-cadherin pathway it also regulates a EPHA2 pathway;In addition our results suggested that miR-200a inhibited VM by negatively regulated EphA2 expression; Consistently the inverse correlation of miR-200a and EphA2 has also been found in ovarian cancer patients; Our research demonstrates that VM miR-200a and EphA2 play key roles in the progression and prognosis of ovarian cancer and for the first time suggests that miR-200a inhibits VM by directly regulating EphA2 ;poor survival;cell migration;progression;worse prognosis breast cancer;breast cancer;ovarian cancer hsa-let-7e-5p EPHA4 0.261471269338985 0.00191077095550257 -1.55269305526411 1.14762781890163e-27 miRNATAP -0.226239270757403 0.000169205133157168 NA NA NA hsa-miR-141-3p EPHA4 2.99777540204168 1.26370498493024e-78 -1.55269305526411 1.14762781890163e-27 mirMAP -0.270231620886409 3.81760465217483e-22 NA NA NA hsa-miR-200a-3p EPHA4 2.55218480823434 2.96135446816238e-51 -1.55269305526411 1.14762781890163e-27 mirMAP -0.208535410030764 5.10863335620484e-14 NA NA NA hsa-miR-141-3p EPHA7 2.99777540204168 1.26370498493024e-78 -2.17929070247088 6.15153712858751e-18 TargetScan;miRNATAP -0.202168479891777 5.29928810824267e-05 26261572 Among those the expression of EPHA7 and PI15 were negatively correlated with that of microRNA-141 and they were also identified as potential targets of this microRNA via microRNA-mRNA interaction; We thus concluded that microRNA-141 EPHA7 and PI15 might jointly participate in the regulation of drug resistance in ovarian cancer and serve as potential targets in targeted therapies drug resistance ovarian cancer hsa-miR-200a-3p EPHA7 2.55218480823434 2.96135446816238e-51 -2.17929070247088 6.15153712858751e-18 miRNATAP -0.201909951301785 3.86585377960352e-05 NA NA NA hsa-miR-28-5p EPM2AIP1 -0.14267073663385 0.0497619246260571 -0.437165458818003 3.86366376911147e-08 miRanda -0.144548878665864 0.000146275825401192 NA NA NA hsa-miR-28-5p EPN1 -0.14267073663385 0.0497619246260571 0.758288535610807 2.09677654098872e-20 miRanda -0.122761755854016 0.00209899863394848 NA NA NA hsa-miR-28-5p EPN2 -0.14267073663385 0.0497619246260571 -0.0264754384448693 0.695378898008471 MirTarget;miRanda -0.161848837849795 4.07182269870998e-07 NA NA NA hsa-miR-200c-3p EPS15 2.07038651806183 6.84613386286599e-51 -0.538952390087797 1.11283135329341e-25 miRNATAP -0.11218100530384 1.35240399026933e-20 NA NA NA hsa-miR-200b-3p EPS8 2.11744072703209 1.66710572104191e-43 -1.29357672864563 9.19667810429944e-38 TargetScan -0.222770622409352 1.29551602210027e-24 NA NA NA hsa-miR-28-5p ERAL1 -0.14267073663385 0.0497619246260571 0.598584957474529 1.72513784158031e-17 miRanda -0.125046069253116 0.000243068164108692 NA NA NA hsa-miR-141-3p ERAP1 2.99777540204168 1.26370498493024e-78 -0.852967400200354 3.24611004098298e-23 mirMAP -0.162369024005508 2.94343159617141e-22 NA NA NA hsa-miR-141-3p ERC2 2.99777540204168 1.26370498493024e-78 -0.812202529557805 1.35392004141974e-06 MirTarget;TargetScan -0.115370146339723 0.000441406748997662 NA NA NA hsa-miR-145-5p ERF -2.62703571936687 7.64402900188551e-88 0.413876366387316 1.25066851005599e-07 MirTarget;miRNATAP -0.133841398074238 1.20750260693153e-13 NA NA NA hsa-miR-141-3p ERG 2.99777540204168 1.26370498493024e-78 -1.79406293965654 1.24967833223395e-59 MirTarget;TargetScan -0.413428999029842 3.1789426836235e-89 NA NA NA hsa-miR-200a-3p ERG 2.55218480823434 2.96135446816238e-51 -1.79406293965654 1.24967833223395e-59 MirTarget -0.328940902899517 1.91474004559624e-54 NA NA NA hsa-miR-200b-3p ERG 2.11744072703209 1.66710572104191e-43 -1.79406293965654 1.24967833223395e-59 TargetScan -0.341571622032645 8.79750059022519e-47 27191272 The tumor suppressive miR 200b subfamily is an ERG target gene in human prostate tumors; Although induction of the tumor suppressive miR-200b subfamily by oncogenic ERG appears to be counterintuitive it is consistent with the observation that the vast majority of primary prostate cancers are slow-growing and indolent prostate cancer hsa-miR-28-5p ERGIC1 -0.14267073663385 0.0497619246260571 0.646215620956665 8.40261132551627e-14 miRanda -0.421087236029744 3.74633309969529e-25 NA NA NA hsa-miR-28-5p ERI2 -0.14267073663385 0.0497619246260571 0.367887024257485 6.00654283242427e-06 miRanda -0.26523497387734 5.06048254756163e-12 NA NA NA hsa-miR-28-5p ERLIN2 -0.14267073663385 0.0497619246260571 0.0041901531172277 0.969544348188735 miRanda -0.253389185184216 1.08006189075056e-06 NA NA NA hsa-miR-132-3p ERMP1 -0.0365213889238607 0.668598301088667 0.84384196405377 7.13232432971762e-16 MirTarget -0.173382486379708 5.53288772842183e-05 NA NA NA hsa-miR-200c-3p ERRFI1 2.07038651806183 6.84613386286599e-51 -1.06077137481255 1.16711058066714e-20 miRNAWalker2_validate;miRTarBase;MirTarget -0.138484555642197 3.0695306989007e-07 NA NA NA hsa-miR-145-5p ESCO2 -2.62703571936687 7.64402900188551e-88 2.864165484727 1.91265101706756e-73 MirTarget -0.471415680439121 3.39517417077516e-34 NA NA NA hsa-miR-205-5p ESM1 -1.70057043266505 1.20976599540743e-09 2.94541481893706 5.89433925774951e-75 miRNATAP -0.102810088662334 1.41663667231459e-06 NA NA NA hsa-miR-132-3p ESR1 -0.0365213889238607 0.668598301088667 0.349232651607838 0.313942462521254 mirMAP -0.720879577095591 2.43271021786454e-07 NA NA NA hsa-miR-132-3p ETNK1 -0.0365213889238607 0.668598301088667 0.195329316720756 0.009730816642529 MirTarget -0.117952536018346 0.000111320436308021 NA NA NA hsa-miR-141-3p ETS1 2.99777540204168 1.26370498493024e-78 -0.979239394867202 3.4732433286646e-20 mirMAP -0.257236667059387 5.62368490791621e-37 NA NA NA hsa-miR-200a-3p ETS1 2.55218480823434 2.96135446816238e-51 -0.979239394867202 3.4732433286646e-20 mirMAP -0.226721918614687 1.27144828161341e-29 NA NA NA hsa-miR-200b-3p ETS1 2.11744072703209 1.66710572104191e-43 -0.979239394867202 3.4732433286646e-20 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.246496070854348 2.76376768290262e-28 NA NA NA hsa-miR-200c-3p ETS1 2.07038651806183 6.84613386286599e-51 -0.979239394867202 3.4732433286646e-20 MirTarget;miRNATAP -0.270324149960465 3.94762137659199e-28 NA NA NA hsa-miR-200b-3p ETS2 2.11744072703209 1.66710572104191e-43 -1.31204961264283 1.86414767606317e-43 TargetScan -0.208203339435452 7.43124017252109e-24 NA NA NA hsa-miR-200b-3p ETV5 2.11744072703209 1.66710572104191e-43 -1.20431287113109 2.191175566387e-29 MirTarget;TargetScan -0.127469651008768 4.90629136908162e-08 27276064 This study aimed to investigate the effect of miR-200b on ERM expression in a breast cancer cell line and its influence on invasion and metastasis ability in vitro; RT-PCR was used to test miR-200b level while Western blot was selected to detect ERM protein expression; RESULTS RT-PCR revealed that miR-200b level in MDA-MB-231 was obviously lower than that in MCF-7 while Western blot analysis showed that ERM expression was significantly higher; MiR-200b inhibition by transfection in MCF-7 markedly decreased miR-200b level elevated ERM expression and enhanced cell migration and invasion; MiR-200b overexpression in MDA-MB-231 obviously increased miR-200b level reduced ERM expression and weakened cell migration and invasion; CONCLUSIONS MiR-200b participates in breast cancer cell migration and invasion through regulating ERM in MCF-7 and MDA-MB-231 metastasis;cell migration breast cancer hsa-miR-200c-3p ETV5 2.07038651806183 6.84613386286599e-51 -1.20431287113109 2.191175566387e-29 MirTarget;miRNATAP -0.134054777062746 1.86122451131347e-07 27276064 Another study suggested that ERM expression was regulated directly by miR-200c and had a critical role in miR-200c suppressing cell migration cell migration breast cancer hsa-miR-200b-3p EVI5 2.11744072703209 1.66710572104191e-43 -0.579984904122258 9.35428980902442e-20 MirTarget;TargetScan -0.122066262280476 1.74550784936078e-19 NA NA NA hsa-miR-200c-3p EVI5 2.07038651806183 6.84613386286599e-51 -0.579984904122258 9.35428980902442e-20 MirTarget;miRNATAP -0.131907912696313 7.68751581111602e-19 NA NA NA hsa-miR-28-5p EXOC6 -0.14267073663385 0.0497619246260571 0.307205555860763 0.000882348548359484 miRanda -0.330426623232935 2.76721875618044e-14 NA NA NA hsa-miR-200b-3p EXOC6B 2.11744072703209 1.66710572104191e-43 -1.11205921642431 1.51544495863844e-13 TargetScan -0.197968867079729 7.27583473908197e-10 NA NA NA hsa-miR-132-3p EYA4 -0.0365213889238607 0.668598301088667 -1.70735688835573 6.25677946773534e-11 miRNAWalker2_validate -0.23586747210908 0.0276804462942293 NA NA NA hsa-miR-145-5p F11R -2.62703571936687 7.64402900188551e-88 0.784299320718817 2.24787898258571e-28 miRNAWalker2_validate -0.117356053758665 3.24546654311589e-12 20818426;26374689 Our data identify JAM-A and fascin as novel targets of miR-145 firmly establishing a role for miR-145 in modulating breast cancer cell motility;MicroRNA screening predicted that microRNA-145 miR-145 would bind to JAM-A; Using patient-derived glioblastoma CSCs we confirmed that JAM-A is suppressed by miR-145 motility; breast cancer;glioblastoma hsa-miR-28-5p F2RL2 -0.14267073663385 0.0497619246260571 1.83288694519631 1.27552904921777e-14 MirTarget;miRanda -0.456824867145525 7.02447930509342e-05 NA NA NA hsa-miR-28-5p FAHD1 -0.14267073663385 0.0497619246260571 0.778155825824243 6.70403995205136e-28 miRanda -0.253441421631961 2.04651536156701e-13 NA NA NA hsa-miR-28-5p FAIM2 -0.14267073663385 0.0497619246260571 -0.153328534808712 0.529442614210649 MirTarget -0.250180763242318 0.0313015616533696 NA NA NA hsa-miR-28-5p FAM110B -0.14267073663385 0.0497619246260571 0.446891190279147 0.00220027405081027 miRanda -0.438812554775886 2.00385789711424e-10 NA NA NA hsa-miR-145-5p FAM110C -2.62703571936687 7.64402900188551e-88 1.08612311763296 6.36539879665119e-08 MirTarget -0.325079308508332 2.6088577890185e-12 NA NA NA hsa-miR-143-3p FAM111A -1.23248181631499 4.74160976678504e-28 0.287398097414218 0.000125064141233486 MirTarget -0.107706913924105 1.1118799040877e-06 NA NA NA hsa-miR-200b-3p FAM126A 2.11744072703209 1.66710572104191e-43 -2.26267854810928 3.52419275607188e-65 TargetScan -0.338188470641347 1.86006972579887e-30 NA NA NA hsa-miR-141-3p FAM133A 2.99777540204168 1.26370498493024e-78 -0.462614622871152 0.0357864947582745 mirMAP -0.247180193144815 6.20999632472482e-09 NA NA NA hsa-miR-200a-3p FAM133A 2.55218480823434 2.96135446816238e-51 -0.462614622871152 0.0357864947582745 mirMAP -0.208831642418516 6.0061359381919e-07 NA NA NA hsa-miR-28-5p FAM134C -0.14267073663385 0.0497619246260571 0.222345364858138 0.000232535871253503 miRanda -0.179678608103432 2.9924102541235e-10 NA NA NA hsa-let-7e-5p FAM135A 0.261471269338985 0.00191077095550257 -1.25723792576387 7.59505292047769e-25 miRNATAP -0.168199735849772 0.0010747158574432 NA NA NA hsa-miR-28-5p FAM135B -0.14267073663385 0.0497619246260571 0.297929137431374 0.2926521551134 MirTarget;miRanda;miRNATAP -0.639664644933673 1.88481695577419e-06 NA NA NA hsa-miR-141-3p FAM150B 2.99777540204168 1.26370498493024e-78 -4.06702877061331 5.65524776776469e-43 MirTarget -0.454365833420014 3.14778667897943e-14 NA NA NA hsa-miR-200a-3p FAM150B 2.55218480823434 2.96135446816238e-51 -4.06702877061331 5.65524776776469e-43 MirTarget -0.335341925606233 1.43910542042615e-08 NA NA NA hsa-miR-28-5p FAM151B -0.14267073663385 0.0497619246260571 0.353772763587107 0.000222374712049446 miRanda -0.356303249159723 2.48752766078358e-15 NA NA NA hsa-miR-205-5p FAM155B -1.70057043266505 1.20976599540743e-09 1.059473854284 1.95949175717375e-07 mirMAP;miRNATAP -0.127317843248596 2.55748163004527e-07 NA NA NA hsa-miR-28-5p FAM160A2 -0.14267073663385 0.0497619246260571 -0.147263090451403 0.00579602030005972 miRanda -0.120301491046325 1.91930813386215e-06 NA NA NA hsa-miR-141-3p FAM160B1 2.99777540204168 1.26370498493024e-78 -0.617695385113071 7.35235824201269e-22 TargetScan -0.12250199614386 9.15173520732588e-23 NA NA NA hsa-miR-141-3p FAM168A 2.99777540204168 1.26370498493024e-78 -0.595647286022841 1.59492655064768e-06 TargetScan -0.102631517583844 2.21136567234435e-05 NA NA NA hsa-miR-28-5p FAM169A -0.14267073663385 0.0497619246260571 0.000732433647964825 0.996131193444778 miRanda -0.173595504883953 0.0158016800253962 NA NA NA hsa-miR-145-5p FAM174B -2.62703571936687 7.64402900188551e-88 0.938847978718496 2.09447872603151e-12 MirTarget -0.172552724689468 3.33903560316177e-08 NA NA NA hsa-miR-132-3p FAM189A1 -0.0365213889238607 0.668598301088667 0.339750291294292 0.199307555843452 mirMAP -0.25890552935038 0.015768441349645 NA NA NA hsa-miR-143-3p FAM196A -1.23248181631499 4.74160976678504e-28 1.98296570560131 3.09651461409495e-10 MirTarget;miRNATAP -0.506109829686638 6.5859025631055e-08 NA NA NA hsa-miR-132-3p FAM199X -0.0365213889238607 0.668598301088667 0.253187015339215 0.000942799939057211 miRNAWalker2_validate;MirTarget -0.188261246093114 9.3797281497346e-10 NA NA NA hsa-miR-200b-3p FAM19A2 2.11744072703209 1.66710572104191e-43 -1.03128328074293 5.23081782144387e-12 MirTarget -0.114337318836679 0.000364810509970369 NA NA NA hsa-miR-200c-3p FAM19A2 2.07038651806183 6.84613386286599e-51 -1.03128328074293 5.23081782144387e-12 MirTarget -0.117472569211795 0.000872791003779172 NA NA NA hsa-miR-143-3p FAM20B -1.23248181631499 4.74160976678504e-28 0.0762927451977209 0.249948625868536 mirMAP -0.108934984904905 2.10266918730568e-08 NA NA NA hsa-miR-141-3p FAM20C 2.99777540204168 1.26370498493024e-78 -0.239487690566357 0.0313275504069408 MirTarget -0.140090967600342 5.94062773113374e-11 NA NA NA hsa-miR-141-3p FAM26E 2.99777540204168 1.26370498493024e-78 -0.82275122127776 5.46439917028421e-11 mirMAP -0.341083058666723 8.43237613195517e-49 NA NA NA hsa-miR-200a-3p FAM26E 2.55218480823434 2.96135446816238e-51 -0.82275122127776 5.46439917028421e-11 mirMAP -0.298564995364986 3.52123043506639e-38 NA NA NA hsa-miR-200b-3p FAM26E 2.11744072703209 1.66710572104191e-43 -0.82275122127776 5.46439917028421e-11 mirMAP -0.336697599830851 2.58381835984909e-39 NA NA NA hsa-miR-145-5p FAM49B -2.62703571936687 7.64402900188551e-88 0.716330772829237 1.654396801579e-19 MirTarget -0.109383628006538 4.75735691217779e-09 NA NA NA hsa-miR-200b-3p FAM63B 2.11744072703209 1.66710572104191e-43 -1.04324614957652 4.45317569057325e-13 TargetScan -0.173181188519981 1.85714062431379e-08 NA NA NA hsa-miR-28-5p FANK1 -0.14267073663385 0.0497619246260571 0.727752467493866 5.08127758503224e-06 miRanda -0.326148845787742 1.8492440727162e-05 NA NA NA hsa-let-7e-5p FASLG 0.261471269338985 0.00191077095550257 0.202786291597416 0.303256769370056 miRNATAP -0.337100053640702 2.69864596660333e-05 NA NA NA hsa-miR-141-3p FAT3 2.99777540204168 1.26370498493024e-78 -1.39927804148844 8.16110526253237e-11 MirTarget;miRNATAP -0.498551032777222 1.30921453727467e-34 NA NA NA hsa-miR-200a-3p FAT3 2.55218480823434 2.96135446816238e-51 -1.39927804148844 8.16110526253237e-11 MirTarget;miRNATAP -0.456732428853608 4.74432434641576e-30 NA NA NA hsa-miR-200b-3p FAT3 2.11744072703209 1.66710572104191e-43 -1.39927804148844 8.16110526253237e-11 MirTarget;TargetScan -0.47348490049486 4.57929919214598e-26 NA NA NA hsa-miR-200c-3p FAT3 2.07038651806183 6.84613386286599e-51 -1.39927804148844 8.16110526253237e-11 MirTarget;miRNATAP -0.550888508321856 3.2823164589328e-29 NA NA NA hsa-miR-200c-3p FBLN5 2.07038651806183 6.84613386286599e-51 -2.08643289665163 1.31128583188143e-54 miRNAWalker2_validate;miRTarBase -0.431582532539337 7.04635991309229e-42 NA NA NA hsa-miR-132-3p FBXL20 -0.0365213889238607 0.668598301088667 -0.0219756735799876 0.832621094283875 MirTarget -0.18527925848266 9.79486297190777e-06 NA NA NA hsa-miR-132-3p FBXO28 -0.0365213889238607 0.668598301088667 0.207643878912418 0.00290746501599163 miRNAWalker2_validate;MirTarget -0.171045732332445 1.00024523781095e-09 NA NA NA hsa-let-7e-5p FBXO32 0.261471269338985 0.00191077095550257 -0.728200631321172 9.08526238939554e-09 miRNATAP -0.187520606495829 0.000327840311146578 NA NA NA hsa-miR-143-3p FBXO46 -1.23248181631499 4.74160976678504e-28 0.956685970981098 1.08201079244471e-38 miRNATAP -0.154404063154588 7.48522598127203e-12 NA NA NA hsa-miR-28-5p FBXW4 -0.14267073663385 0.0497619246260571 -0.0900849463685356 0.206348671758354 miRanda -0.152099944153854 6.63763082332348e-06 NA NA NA hsa-miR-200b-3p FBXW7 2.11744072703209 1.66710572104191e-43 -1.04726780821632 1.02766405186634e-61 TargetScan -0.115533487792978 4.42176858537462e-16 NA NA NA hsa-miR-28-5p FCGRT -0.14267073663385 0.0497619246260571 -0.474452179789248 1.11132066883725e-05 miRanda -0.234186660196465 5.33644165622309e-06 NA NA NA hsa-miR-200c-3p FCHO2 2.07038651806183 6.84613386286599e-51 -0.606061420659775 1.08535609457921e-15 mirMAP -0.101098280823348 1.35123496996583e-08 NA NA NA hsa-miR-28-5p FCHO2 -0.14267073663385 0.0497619246260571 -0.606061420659775 1.08535609457921e-15 miRanda -0.141100901822869 0.000112527994366655 NA NA NA hsa-miR-132-3p FEM1C -0.0365213889238607 0.668598301088667 -0.260293397561805 0.000498044801322955 MirTarget;miRNATAP -0.175580554414946 5.29522024566136e-09 NA NA NA hsa-miR-28-5p FEM1C -0.14267073663385 0.0497619246260571 -0.260293397561805 0.000498044801322955 MirTarget;PITA;miRanda -0.176460573027483 6.55806438951583e-07 NA NA NA hsa-miR-141-3p FER 2.99777540204168 1.26370498493024e-78 -1.39984522785187 1.37974026576335e-30 mirMAP -0.260716767655561 5.65369583972009e-28 NA NA NA hsa-miR-200a-3p FER 2.55218480823434 2.96135446816238e-51 -1.39984522785187 1.37974026576335e-30 mirMAP -0.237419580733984 4.27184059308637e-24 NA NA NA hsa-miR-28-5p FER1L5 -0.14267073663385 0.0497619246260571 -1.49525147289193 7.39872679440538e-10 miRNATAP -0.496968741212832 2.00450604806538e-05 NA NA NA hsa-miR-200b-3p FERMT2 2.11744072703209 1.66710572104191e-43 -1.85633940208907 3.36734523172304e-65 TargetScan -0.385571245951135 5.50529908068042e-62 23483548;24064224;26334393 Here we report that Kindlin 2 markedly downregulates the expression of miR-200 family by inducing CpG island hypermethylation; Our data indicate that Kindlin 2 plays a novel role in epigenetic repression of miR-200 family a mechanism that promotes breast cancer invasion;miR 200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin 2; Quantitative mass spectrometry identified 57 putative miR-200b targets including Kindlin-2 previously implicated in the regulation of tumor invasiveness and actin cytoskeleton in other cell types; Enforced expression of miR-200b mimic in ESCC cells led to a decrease of Kindlin-2 expression whereas transfection of miR-200b inhibitor induced Kindlin-2 expression; Furthermore transfection of miR-200b mimic or knockdown of Kindlin-2 in ESCC cells decreased cell protrusion and focal adhesion FA formation reduced cell spreading and invasiveness/migration; Enforced expression of Kindlin-2 largely abrogated the inhibitory effects of miR-200b on ESCC cell invasiveness; The tumor suppressor effects of miR-200b may be due to its suppression of Kindlin-2 a novel target of miR-200b that modulates actin cytoskeleton FA formation and the migratory/invasiveness properties of ESCC;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ;; breast cancer;esophageal cancer;esophageal cancer hsa-miR-200b-3p FEZ2 2.11744072703209 1.66710572104191e-43 -0.850269532845046 1.36966796237694e-51 TargetScan -0.19460972551043 2.10235060115672e-61 NA NA NA hsa-miR-200b-3p FGF10 2.11744072703209 1.66710572104191e-43 -3.32771291998068 2.19492306477012e-23 TargetScan -0.477562798964516 3.55044319062017e-11 NA NA NA hsa-miR-200b-3p FGF12 2.11744072703209 1.66710572104191e-43 -0.643446523257955 0.000892623765099953 TargetScan -0.165329959072644 5.71604844896826e-05 NA NA NA hsa-miR-141-3p FGF13 2.99777540204168 1.26370498493024e-78 -0.873614793965912 3.10323995957847e-07 TargetScan -0.151235108253828 5.55097538879746e-06 NA NA NA hsa-miR-200b-3p FGF18 2.11744072703209 1.66710572104191e-43 0.356025539172725 0.0347430848266563 TargetScan -0.225608292610904 1.9483944408265e-10 NA NA NA hsa-miR-200c-3p FGF18 2.07038651806183 6.84613386286599e-51 0.356025539172725 0.0347430848266563 miRNATAP -0.297918294437242 1.5236208240269e-14 NA NA NA hsa-miR-200b-3p FGF2 2.11744072703209 1.66710572104191e-43 -3.62110997961421 1.11252046868458e-69 mirMAP -0.474105291344653 1.09246839719196e-24 NA NA NA hsa-miR-200c-3p FGF2 2.07038651806183 6.84613386286599e-51 -3.62110997961421 1.11252046868458e-69 mirMAP -0.615252170517975 1.40903756446366e-34 NA NA NA hsa-miR-200b-3p FHL1 2.11744072703209 1.66710572104191e-43 -4.39641190571109 2.95720924032036e-115 MirTarget -0.744315582307958 1.69874929324822e-65 NA NA NA hsa-miR-200c-3p FHL1 2.07038651806183 6.84613386286599e-51 -4.39641190571109 2.95720924032036e-115 MirTarget -0.950076194934803 5.31550297000954e-94 NA NA NA hsa-miR-200c-3p FHOD1 2.07038651806183 6.84613386286599e-51 0.172964188564771 0.0354183224027716 miRNAWalker2_validate -0.113582055183826 2.29895309973769e-09 22144583 MicroRNA 200c represses migration and invasion of breast cancer cells by targeting actin regulatory proteins FHOD1 and PPM1F; We identified FHOD1 and PPM1F direct regulators of the actin cytoskeleton as novel targets of miR-200c; Remarkably expression levels of FHOD1 and PPM1F were inversely correlated with the level of miR-200c in breast cancer cell lines breast cancer patient samples and 58 cancer cell lines of various origins breast cancer hsa-let-7e-5p FIGN 0.261471269338985 0.00191077095550257 -2.43971791427329 1.33964701286684e-33 MirTarget -0.309849875964227 0.000314847471579114 NA NA NA hsa-miR-200b-3p FIGN 2.11744072703209 1.66710572104191e-43 -2.43971791427329 1.33964701286684e-33 MirTarget;TargetScan -0.3086064903629 2.68535224605977e-12 NA NA NA hsa-miR-200c-3p FIGN 2.07038651806183 6.84613386286599e-51 -2.43971791427329 1.33964701286684e-33 MirTarget -0.366212076105834 3.8753590581544e-14 NA NA NA hsa-let-7e-5p FIGNL2 0.261471269338985 0.00191077095550257 -1.10908313704482 2.31754860335187e-22 MirTarget -0.104678524753997 0.0289796693874394 NA NA NA hsa-miR-200b-3p FIGNL2 2.11744072703209 1.66710572104191e-43 -1.10908313704482 2.31754860335187e-22 MirTarget -0.207168682643263 1.87481290546471e-17 NA NA NA hsa-miR-200c-3p FIGNL2 2.07038651806183 6.84613386286599e-51 -1.10908313704482 2.31754860335187e-22 MirTarget -0.294790594129615 5.73968702863584e-29 NA NA NA hsa-miR-200b-3p FKBP14 2.11744072703209 1.66710572104191e-43 -0.131038750294068 0.167370353404485 mirMAP -0.163926566035403 1.05075402286229e-16 NA NA NA hsa-miR-200c-3p FKBP14 2.07038651806183 6.84613386286599e-51 -0.131038750294068 0.167370353404485 mirMAP -0.171110973771157 3.7988121456562e-15 NA NA NA hsa-miR-141-3p FKBP5 2.99777540204168 1.26370498493024e-78 -0.910640773205637 6.12828690619755e-09 TargetScan -0.181359586066222 2.67907589087188e-09 NA NA NA hsa-miR-28-5p FKTN -0.14267073663385 0.0497619246260571 0.0913291179055893 0.215754519232549 miRanda -0.144817438914449 3.46968527462469e-05 NA NA NA hsa-miR-141-3p FLI1 2.99777540204168 1.26370498493024e-78 -1.26235715548629 4.88985347259214e-39 TargetScan -0.32279791085111 7.55604268824049e-72 NA NA NA hsa-miR-200b-3p FLI1 2.11744072703209 1.66710572104191e-43 -1.26235715548629 4.88985347259214e-39 MirTarget;TargetScan -0.289627913352371 3.97191849335038e-46 NA NA NA hsa-miR-200c-3p FLI1 2.07038651806183 6.84613386286599e-51 -1.26235715548629 4.88985347259214e-39 MirTarget;miRNATAP -0.344352033600828 8.39565566372828e-55 NA NA NA hsa-miR-200c-3p FLNA 2.07038651806183 6.84613386286599e-51 -0.588648086634478 1.12488656429227e-08 miRNAWalker2_validate -0.200293197507804 3.85868552345297e-17 NA NA NA hsa-miR-145-5p FLRT1 -2.62703571936687 7.64402900188551e-88 0.229763079908531 0.0959873153649617 MirTarget -0.112271031696962 0.000453704755409779 NA NA NA hsa-miR-200b-3p FLT1 2.11744072703209 1.66710572104191e-43 -0.976682151789582 4.79604479745106e-23 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.237387253520266 3.06104626134544e-30 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-200c-3p FLT1 2.07038651806183 6.84613386286599e-51 -0.976682151789582 4.79604479745106e-23 miRNAWalker2_validate;miRTarBase;MirTarget -0.255668357647663 5.50361375778068e-29 NA NA NA hsa-miR-28-5p FLYWCH1 -0.14267073663385 0.0497619246260571 0.12389624476354 0.117705319180408 miRanda -0.229517717967346 7.89386614037077e-10 NA NA NA hsa-let-7e-5p FMO4 0.261471269338985 0.00191077095550257 -0.704973060634884 1.23843882922657e-13 MirTarget -0.164074434738195 3.06793601398614e-05 NA NA NA hsa-let-7e-5p FNDC3B 0.261471269338985 0.00191077095550257 -0.617097925266489 2.23433634850295e-11 miRNATAP -0.122438571054317 0.00132660017841253 NA NA NA hsa-miR-141-3p FNDC3B 2.99777540204168 1.26370498493024e-78 -0.617097925266489 2.23433634850295e-11 MirTarget;TargetScan -0.131420157531359 2.06868214521734e-13 NA NA NA hsa-miR-200a-3p FNDC3B 2.55218480823434 2.96135446816238e-51 -0.617097925266489 2.23433634850295e-11 MirTarget -0.122330732120618 3.48253775867492e-12 NA NA NA hsa-miR-200b-3p FNDC3B 2.11744072703209 1.66710572104191e-43 -0.617097925266489 2.23433634850295e-11 MirTarget;TargetScan -0.156400322557984 9.38003443415968e-16 NA NA NA hsa-miR-200c-3p FNDC3B 2.07038651806183 6.84613386286599e-51 -0.617097925266489 2.23433634850295e-11 MirTarget;miRNATAP -0.168526971666725 3.63146291373359e-15 NA NA NA hsa-miR-141-3p FNIP2 2.99777540204168 1.26370498493024e-78 -1.39702732424967 8.59594770424294e-21 TargetScan -0.280599316860777 4.16722031597609e-22 NA NA NA hsa-miR-132-3p FOXA1 -0.0365213889238607 0.668598301088667 1.93357429067537 2.83703257541696e-09 miRNATAP -0.746233393794386 1.63927032085846e-08 NA NA NA hsa-miR-141-3p FOXC1 2.99777540204168 1.26370498493024e-78 -1.56967295609977 3.50287816253511e-14 TargetScan -0.153905479977761 0.000164426354303397 NA NA NA hsa-miR-145-5p FOXD4 -2.62703571936687 7.64402900188551e-88 1.71498662665658 1.83047665294251e-29 MirTarget -0.346975415639868 2.72569411358494e-22 NA NA NA hsa-miR-145-5p FOXD4L1 -2.62703571936687 7.64402900188551e-88 1.76876840447172 2.27012134835503e-33 MirTarget -0.378003056136083 4.66714655846817e-28 NA NA NA hsa-miR-200b-3p FOXF1 2.11744072703209 1.66710572104191e-43 0.291118837928196 0.0286763951936233 MirTarget;TargetScan -0.14491240041732 2.45591589496998e-07 NA NA NA hsa-miR-200c-3p FOXF1 2.07038651806183 6.84613386286599e-51 0.291118837928196 0.0286763951936233 MirTarget -0.150915017821127 1.04078828830041e-06 NA NA NA hsa-miR-200b-3p FOXF2 2.11744072703209 1.66710572104191e-43 0.0862026827601208 0.512388199995853 TargetScan -0.121362215613563 1.26130100638394e-05 25798833 The miR 200 family and the miR 183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers; We therefore identified a novel mechanism whereby the miR-200 family and the miR-183~96~182 cluster inhibit lung cancer invasion and metastasis by targeting Foxf2 metastasis lung cancer hsa-miR-200c-3p FOXF2 2.07038651806183 6.84613386286599e-51 0.0862026827601208 0.512388199995853 miRNATAP -0.160981197343451 1.28422651580948e-07 NA NA NA hsa-miR-28-5p FOXN1 -0.14267073663385 0.0497619246260571 0.0889187669149409 0.713281219357253 miRNATAP -0.879616137405977 8.89872783886835e-15 NA NA NA hsa-miR-200b-3p FOXN2 2.11744072703209 1.66710572104191e-43 -1.15146301932722 1.86981509490569e-31 TargetScan -0.216067297784938 1.6207167544195e-24 NA NA NA hsa-miR-141-3p FOXN3 2.99777540204168 1.26370498493024e-78 -1.6997111136462 5.59981199956681e-76 MirTarget;TargetScan;miRNATAP -0.346154028249218 5.50654100716566e-85 NA NA NA hsa-miR-200a-3p FOXN3 2.55218480823434 2.96135446816238e-51 -1.6997111136462 5.59981199956681e-76 MirTarget;miRNATAP -0.309014315126777 9.68107206991495e-68 NA NA NA hsa-miR-200b-3p FOXN3 2.11744072703209 1.66710572104191e-43 -1.6997111136462 5.59981199956681e-76 mirMAP -0.331522889759846 2.61605387533255e-62 NA NA NA hsa-miR-141-3p FOXO1 2.99777540204168 1.26370498493024e-78 -1.98726551876693 3.0579805549685e-75 mirMAP -0.419566743640224 5.4571001142745e-92 NA NA NA hsa-miR-200a-3p FOXO1 2.55218480823434 2.96135446816238e-51 -1.98726551876693 3.0579805549685e-75 mirMAP -0.354580454287537 3.3835357109995e-64 NA NA NA hsa-miR-132-3p FOXP1 -0.0365213889238607 0.668598301088667 -0.35411257741511 5.07710017842764e-05 miRNATAP -0.225789294754448 1.32774767856084e-10 NA NA NA hsa-miR-28-5p FOXP1 -0.14267073663385 0.0497619246260571 -0.35411257741511 5.07710017842764e-05 miRNATAP -0.253017374532554 9.78497660973651e-10 NA NA NA hsa-miR-141-3p FOXP2 2.99777540204168 1.26370498493024e-78 -3.10671503377831 7.7457852611569e-43 TargetScan -0.612782679753809 4.65276045556256e-44 NA NA NA hsa-miR-200b-3p FREM2 2.11744072703209 1.66710572104191e-43 -1.24367958988493 0.000230765369099563 TargetScan;mirMAP -0.258605468756909 0.000314408791569484 NA NA NA hsa-miR-200b-3p FRMD3 2.11744072703209 1.66710572104191e-43 -2.57949043338413 1.34979420509153e-35 mirMAP -0.265670397410008 5.59023588171974e-09 NA NA NA hsa-miR-141-3p FRMD4A 2.99777540204168 1.26370498493024e-78 -1.01645361935313 1.41995569982009e-35 MirTarget;TargetScan;miRNATAP -0.155087652439246 8.62253250371953e-22 NA NA NA hsa-miR-200a-3p FRMD4A 2.55218480823434 2.96135446816238e-51 -1.01645361935313 1.41995569982009e-35 MirTarget;miRNATAP -0.151966445379609 9.74481066109446e-22 NA NA NA hsa-miR-200b-3p FRMD4A 2.11744072703209 1.66710572104191e-43 -1.01645361935313 1.41995569982009e-35 MirTarget;TargetScan -0.167102449464382 2.94003680494319e-21 NA NA NA hsa-miR-200c-3p FRMD4A 2.07038651806183 6.84613386286599e-51 -1.01645361935313 1.41995569982009e-35 MirTarget -0.178469341949458 4.37545129528689e-20 NA NA NA hsa-miR-200b-3p FRMD4B 2.11744072703209 1.66710572104191e-43 -0.791884465310464 1.80164221616731e-17 TargetScan -0.123399803212915 6.30082911157813e-10 NA NA NA hsa-miR-141-3p FRMD6 2.99777540204168 1.26370498493024e-78 -0.866699035031564 6.18218400177215e-15 MirTarget;TargetScan;miRNATAP -0.210703663785569 6.94058503459482e-23 NA NA NA hsa-miR-200a-3p FRMD6 2.55218480823434 2.96135446816238e-51 -0.866699035031564 6.18218400177215e-15 MirTarget;miRNATAP -0.16417507171658 1.01344056716179e-14 NA NA NA hsa-miR-200b-3p FRMD6 2.11744072703209 1.66710572104191e-43 -0.866699035031564 6.18218400177215e-15 TargetScan -0.151525640921733 1.71424374610769e-10 NA NA NA hsa-miR-200c-3p FRMD6 2.07038651806183 6.84613386286599e-51 -0.866699035031564 6.18218400177215e-15 miRNATAP -0.208288866495126 9.17125871002378e-16 NA NA NA hsa-miR-132-3p FRS2 -0.0365213889238607 0.668598301088667 -0.151534815530378 0.172700768380748 MirTarget -0.18734349027881 2.94093351040939e-05 NA NA NA hsa-miR-132-3p FRY -0.0365213889238607 0.668598301088667 -1.13354365828084 2.35583827383817e-18 miRNAWalker2_validate -0.144520699616158 0.00708495916317562 NA NA NA hsa-miR-141-3p FRY 2.99777540204168 1.26370498493024e-78 -1.13354365828084 2.35583827383817e-18 miRNATAP -0.199769479412601 3.26827769248094e-15 NA NA NA hsa-miR-200a-3p FRY 2.55218480823434 2.96135446816238e-51 -1.13354365828084 2.35583827383817e-18 miRNATAP -0.152089514355465 1.28001824319125e-09 NA NA NA hsa-miR-200b-3p FSTL1 2.11744072703209 1.66710572104191e-43 -1.28139008179553 1.01404950224375e-26 MirTarget;TargetScan -0.360497287154624 3.72936436031533e-48 NA NA NA hsa-miR-200c-3p FSTL1 2.07038651806183 6.84613386286599e-51 -1.28139008179553 1.01404950224375e-26 MirTarget -0.453998296697041 2.3449872421462e-65 NA NA NA hsa-miR-141-3p FTO 2.99777540204168 1.26370498493024e-78 -1.00223220745244 1.98834905469873e-28 mirMAP -0.119852449581978 3.00395404384543e-11 NA NA NA hsa-miR-200b-3p FUT4 2.11744072703209 1.66710572104191e-43 -0.679443089509878 4.66310915975363e-15 TargetScan -0.129088310698467 2.76147215488589e-12 NA NA NA hsa-miR-28-5p FUT8 -0.14267073663385 0.0497619246260571 0.726014580237623 6.08952916861957e-11 miRanda -0.425606323456591 5.65560664857273e-16 NA NA NA hsa-miR-141-3p FYCO1 2.99777540204168 1.26370498493024e-78 -0.837636641815681 9.41294109419175e-23 mirMAP -0.175826275085786 1.74617797613534e-26 NA NA NA hsa-miR-200a-3p FYCO1 2.55218480823434 2.96135446816238e-51 -0.837636641815681 9.41294109419175e-23 mirMAP -0.133059467373794 5.43462096573711e-16 NA NA NA hsa-miR-200b-3p FYN 2.11744072703209 1.66710572104191e-43 -0.965287085760175 3.05410879931046e-23 TargetScan -0.256321683539745 1.20065225224339e-36 NA NA NA hsa-miR-200c-3p FYN 2.07038651806183 6.84613386286599e-51 -0.965287085760175 3.05410879931046e-23 miRNATAP -0.314645625793321 2.33665324756776e-46 NA NA NA hsa-let-7e-5p FZD4 0.261471269338985 0.00191077095550257 -2.45778080887863 8.2466362913083e-83 MirTarget;miRNATAP -0.142834413823916 0.0136912438497173 NA NA NA hsa-miR-132-3p FZD4 -0.0365213889238607 0.668598301088667 -2.45778080887863 8.2466362913083e-83 mirMAP -0.131849182622165 0.0215519807956623 NA NA NA hsa-miR-141-3p FZD4 2.99777540204168 1.26370498493024e-78 -2.45778080887863 8.2466362913083e-83 TargetScan -0.485144243770508 8.88244662789011e-86 NA NA NA hsa-miR-200b-3p FZD4 2.11744072703209 1.66710572104191e-43 -2.45778080887863 8.2466362913083e-83 mirMAP -0.443472478111004 1.62241648876776e-56 NA NA NA hsa-miR-200c-3p FZD4 2.07038651806183 6.84613386286599e-51 -2.45778080887863 8.2466362913083e-83 mirMAP -0.5394698778619 2.40222703670541e-71 NA NA NA hsa-miR-200a-3p FZD5 2.55218480823434 2.96135446816238e-51 -1.30576854554188 8.3393662705584e-32 mirMAP -0.193303591193815 3.54560151752924e-19 NA NA NA hsa-miR-132-3p GAB1 -0.0365213889238607 0.668598301088667 -0.692166188366933 9.18798859765721e-16 mirMAP -0.118417638517452 0.000834185182165966 NA NA NA hsa-miR-141-3p GAB1 2.99777540204168 1.26370498493024e-78 -0.692166188366933 9.18798859765721e-16 MirTarget;TargetScan -0.120372236176324 8.11764203508008e-13 NA NA NA hsa-miR-200b-3p GABRB3 2.11744072703209 1.66710572104191e-43 -1.54942182708902 1.18499394645321e-06 TargetScan;mirMAP -0.281534254670845 3.37682375365578e-05 NA NA NA hsa-miR-200c-3p GABRB3 2.07038651806183 6.84613386286599e-51 -1.54942182708902 1.18499394645321e-06 mirMAP -0.366813338721231 8.51819965183799e-07 NA NA NA hsa-miR-28-5p GALNT10 -0.14267073663385 0.0497619246260571 0.227833941975381 0.0563309072028891 miRanda -0.324201567304107 9.22307992385576e-09 NA NA NA hsa-miR-28-5p GALNT6 -0.14267073663385 0.0497619246260571 1.53253468503729 1.95615996419132e-15 miRanda -0.690592453180032 6.97388105280589e-14 NA NA NA hsa-miR-143-3p GALNT7 -1.23248181631499 4.74160976678504e-28 1.0914967844721 3.39918948596231e-14 MirTarget;miRNATAP -0.297561773092823 3.47946681559885e-12 NA NA NA hsa-miR-200b-3p GATA2 2.11744072703209 1.66710572104191e-43 -0.140432100799638 0.470531651480733 TargetScan -0.154914225633704 0.000168590571516974 NA NA NA hsa-miR-200c-3p GATA2 2.07038651806183 6.84613386286599e-51 -0.140432100799638 0.470531651480733 miRNATAP -0.162448976897229 0.00033567348174011 NA NA NA hsa-miR-132-3p GATA3 -0.0365213889238607 0.668598301088667 1.5576496597582 2.58751948867418e-11 miRNAWalker2_validate -0.623902878863514 4.61869800965351e-11 NA NA NA hsa-miR-141-3p GATA6 2.99777540204168 1.26370498493024e-78 -0.699851594860171 1.92456260924552e-07 TargetScan;miRNATAP -0.134449805077958 2.77866092858394e-07 NA NA NA hsa-miR-200a-3p GATA6 2.55218480823434 2.96135446816238e-51 -0.699851594860171 1.92456260924552e-07 miRNAWalker2_validate;miRNATAP -0.127017900812787 7.63206405009383e-07 NA NA NA hsa-miR-28-5p GATAD1 -0.14267073663385 0.0497619246260571 -0.118787232382459 0.0381461411955589 miRanda -0.220960335790874 1.44173216936157e-16 NA NA NA hsa-miR-145-5p GATC -2.62703571936687 7.64402900188551e-88 0.310045268767208 0.000461165940709552 MirTarget -0.104974833197868 3.0068913737638e-07 NA NA NA hsa-let-7e-5p GATM 0.261471269338985 0.00191077095550257 -0.791153922275685 1.74092462595563e-07 MirTarget;miRNATAP -0.135298038692859 0.0302405429728584 NA NA NA hsa-miR-28-5p GATM -0.14267073663385 0.0497619246260571 -0.791153922275685 1.74092462595563e-07 miRanda -0.205174678583206 0.00473288183325133 NA NA NA hsa-miR-200b-3p GBP4 2.11744072703209 1.66710572104191e-43 -0.502395556019755 0.0012264052654199 mirMAP -0.159450999465721 1.24307304900707e-06 NA NA NA hsa-miR-28-5p GCM1 -0.14267073663385 0.0497619246260571 0.360191323603245 0.134565410281452 miRanda -0.488569605079757 1.91929018001998e-05 NA NA NA hsa-miR-141-3p GCNT4 2.99777540204168 1.26370498493024e-78 -2.07187899362037 1.85247504296876e-28 TargetScan -0.364846855091179 2.77113107228307e-23 NA NA NA hsa-miR-141-3p GDF6 2.99777540204168 1.26370498493024e-78 -0.388623710302829 0.0268119680640758 TargetScan -0.245691412390661 3.02382137529226e-13 NA NA NA hsa-miR-200b-3p GDF6 2.11744072703209 1.66710572104191e-43 -0.388623710302829 0.0268119680640758 TargetScan -0.235189970868671 1.83473115362667e-10 NA NA NA hsa-miR-141-3p GEM 2.99777540204168 1.26370498493024e-78 -1.31064474948309 3.35918949026588e-21 MirTarget -0.348552712353379 5.36878261091719e-40 NA NA NA hsa-miR-200a-3p GEM 2.55218480823434 2.96135446816238e-51 -1.31064474948309 3.35918949026588e-21 MirTarget -0.272868820275543 3.85481987191298e-25 NA NA NA hsa-miR-200b-3p GEM 2.11744072703209 1.66710572104191e-43 -1.31064474948309 3.35918949026588e-21 MirTarget -0.252352371736365 1.51025792341624e-17 NA NA NA hsa-miR-200c-3p GEM 2.07038651806183 6.84613386286599e-51 -1.31064474948309 3.35918949026588e-21 MirTarget;miRNATAP -0.335050212119271 2.44070410189031e-25 NA NA NA hsa-miR-132-3p GFRA1 -0.0365213889238607 0.668598301088667 -0.692412159332901 0.064695425447951 mirMAP -0.785999639827809 1.93406984370852e-07 NA NA NA hsa-miR-141-3p GFRA1 2.99777540204168 1.26370498493024e-78 -0.692412159332901 0.064695425447951 mirMAP -0.167089725636287 0.0219950061737178 NA NA NA hsa-miR-141-3p GFRA2 2.99777540204168 1.26370498493024e-78 -2.62832301970864 3.54115116223358e-39 mirMAP -0.574806492171226 2.21900306521903e-50 NA NA NA hsa-miR-200a-3p GFRA2 2.55218480823434 2.96135446816238e-51 -2.62832301970864 3.54115116223358e-39 mirMAP -0.438591314587542 1.35604664373649e-29 NA NA NA hsa-miR-200a-3p GIMAP1 2.55218480823434 2.96135446816238e-51 -1.14090140112924 1.29318417460205e-16 mirMAP -0.19553007276345 1.40211663424468e-13 NA NA NA hsa-miR-28-5p GIPR -0.14267073663385 0.0497619246260571 0.017258044160555 0.935509804568678 miRanda -0.685109906674805 8.75524546773542e-12 NA NA NA hsa-miR-200c-3p GIT2 2.07038651806183 6.84613386286599e-51 -0.336020253372316 1.73645416728317e-15 MirTarget;miRNATAP -0.100168641242341 4.55546604514242e-25 NA NA NA hsa-miR-145-5p GJA3 -2.62703571936687 7.64402900188551e-88 2.03278137397596 1.4130486243529e-24 MirTarget -0.256395241360959 5.73713435788977e-08 NA NA NA hsa-miR-141-3p GJC1 2.99777540204168 1.26370498493024e-78 -0.204948069311232 0.0558702919863598 MirTarget;TargetScan;miRNATAP -0.127727914623235 6.12697367691871e-10 NA NA NA hsa-miR-200a-3p GJC1 2.55218480823434 2.96135446816238e-51 -0.204948069311232 0.0558702919863598 MirTarget;miRNATAP -0.145199560968071 6.13400378527903e-13 NA NA NA hsa-miR-200b-3p GJC1 2.11744072703209 1.66710572104191e-43 -0.204948069311232 0.0558702919863598 MirTarget;TargetScan -0.176114849877955 3.47662579134373e-15 NA NA NA hsa-miR-200c-3p GJC1 2.07038651806183 6.84613386286599e-51 -0.204948069311232 0.0558702919863598 MirTarget;miRNATAP -0.177640718193948 6.03263964972077e-13 NA NA NA hsa-miR-28-5p GKAP1 -0.14267073663385 0.0497619246260571 -0.51386963839469 2.55435086487334e-08 miRanda -0.154887800263099 0.000460548342740559 NA NA NA hsa-miR-141-3p GLDN 2.99777540204168 1.26370498493024e-78 -2.61650983542568 1.11303088078107e-39 MirTarget -0.486032533124165 6.06583711765146e-36 NA NA NA hsa-miR-200a-3p GLDN 2.55218480823434 2.96135446816238e-51 -2.61650983542568 1.11303088078107e-39 MirTarget -0.424820200840999 2.45625499473469e-28 NA NA NA hsa-miR-200b-3p GLG1 2.11744072703209 1.66710572104191e-43 -0.496855757011849 1.36067250511171e-17 TargetScan -0.11154435989524 1.1641673862493e-19 NA NA NA hsa-miR-141-3p GLI2 2.99777540204168 1.26370498493024e-78 -0.809812833399723 1.77977002621718e-08 MirTarget -0.333509982639127 5.41463993853588e-35 NA NA NA hsa-miR-200a-3p GLI2 2.55218480823434 2.96135446816238e-51 -0.809812833399723 1.77977002621718e-08 MirTarget -0.276570337072336 7.57698921345758e-25 NA NA NA hsa-let-7e-5p GLRX 0.261471269338985 0.00191077095550257 0.257200421672396 0.0202023020991661 MirTarget -0.171440565147556 0.000150066045158978 NA NA NA hsa-miR-141-3p GNAI1 2.99777540204168 1.26370498493024e-78 -2.59725421035606 4.41129786088359e-78 TargetScan -0.408299073467948 7.17887803089354e-48 NA NA NA hsa-let-7e-5p GNAL 0.261471269338985 0.00191077095550257 -2.95778057421271 1.93427241053864e-70 miRNATAP -0.164983222134469 0.0270397116502964 NA NA NA hsa-miR-141-3p GNAQ 2.99777540204168 1.26370498493024e-78 -0.708451286886118 2.10962512697924e-15 MirTarget -0.116529482917389 2.48345872468237e-11 NA NA NA hsa-miR-200a-3p GNAQ 2.55218480823434 2.96135446816238e-51 -0.708451286886118 2.10962512697924e-15 MirTarget -0.111393679222787 8.1020608530641e-11 NA NA NA hsa-miR-200b-3p GNAQ 2.11744072703209 1.66710572104191e-43 -0.708451286886118 2.10962512697924e-15 TargetScan -0.11430812398522 2.16983122874448e-09 NA NA NA hsa-miR-141-3p GNE 2.99777540204168 1.26370498493024e-78 -1.03696689854156 5.56635729181646e-30 MirTarget -0.14500000506443 1.01694996635721e-15 NA NA NA hsa-miR-200a-3p GNE 2.55218480823434 2.96135446816238e-51 -1.03696689854156 5.56635729181646e-30 MirTarget -0.127198364193185 8.84895824382958e-13 NA NA NA hsa-miR-141-3p GNG7 2.99777540204168 1.26370498493024e-78 -1.27893544175867 1.22567787829192e-21 MirTarget;TargetScan;miRNATAP -0.160816727393679 1.22991601143051e-09 NA NA NA hsa-miR-143-3p GNL3 -1.23248181631499 4.74160976678504e-28 0.347239134871017 3.98329582560354e-10 MirTarget -0.119326843382789 2.7843953249836e-13 NA NA NA hsa-miR-200b-3p GOLIM4 2.11744072703209 1.66710572104191e-43 -0.506535769934108 0.00010441305803676 TargetScan -0.195075752356037 1.16251820238862e-12 NA NA NA hsa-miR-143-3p GOLM1 -1.23248181631499 4.74160976678504e-28 1.26468872915984 1.10705867867101e-25 MirTarget -0.264358356908934 3.58679664458612e-13 NA NA NA hsa-miR-145-5p GOLM1 -2.62703571936687 7.64402900188551e-88 1.26468872915984 1.10705867867101e-25 miRNAWalker2_validate;MirTarget -0.219019492251804 1.50214750904505e-14 NA NA NA hsa-miR-28-5p GOSR1 -0.14267073663385 0.0497619246260571 0.030365365851841 0.621004932234963 miRanda;mirMAP -0.101953135923577 0.000463895107781679 NA NA NA hsa-miR-141-3p GPAM 2.99777540204168 1.26370498493024e-78 -3.76340793083535 6.90651818189149e-141 MirTarget -0.595191637115214 3.19635951075136e-81 NA NA NA hsa-miR-200a-3p GPAM 2.55218480823434 2.96135446816238e-51 -3.76340793083535 6.90651818189149e-141 MirTarget -0.50035434320779 1.43449916572614e-56 NA NA NA hsa-miR-132-3p GPBP1 -0.0365213889238607 0.668598301088667 -0.0137041815437682 0.770311932798486 MirTarget -0.106752620894502 1.29440856831597e-08 NA NA NA hsa-miR-28-5p GPBP1 -0.14267073663385 0.0497619246260571 -0.0137041815437682 0.770311932798486 miRanda -0.127042004309214 8.6747456269106e-09 NA NA NA hsa-miR-141-3p GPC6 2.99777540204168 1.26370498493024e-78 -0.885655085868431 1.40422629455049e-06 TargetScan -0.364331309987999 1.41757400628427e-25 NA NA NA hsa-miR-200b-3p GPC6 2.11744072703209 1.66710572104191e-43 -0.885655085868431 1.40422629455049e-06 TargetScan -0.376990233935591 5.14299665466106e-23 NA NA NA hsa-let-7e-5p GPCPD1 0.261471269338985 0.00191077095550257 -0.755743323923126 1.58505545075048e-17 miRNATAP -0.177247232454764 1.48947939764116e-06 NA NA NA hsa-miR-141-3p GPD1 2.99777540204168 1.26370498493024e-78 -6.26299533147511 8.19883574270344e-72 TargetScan -1.01936339700388 8.35634193156972e-48 NA NA NA hsa-miR-132-3p GPD2 -0.0365213889238607 0.668598301088667 0.210900888733789 0.0264157292786502 miRNATAP -0.152422618176201 7.12369361727854e-05 NA NA NA hsa-miR-28-5p GPD2 -0.14267073663385 0.0497619246260571 0.210900888733789 0.0264157292786502 miRanda -0.129869118527292 0.00409414238800342 NA NA NA hsa-miR-200b-3p GPM6A 2.11744072703209 1.66710572104191e-43 -3.10286839785086 3.20941823581068e-24 TargetScan -0.371794675320626 2.05632837550936e-08 NA NA NA hsa-miR-200c-3p GPM6A 2.07038651806183 6.84613386286599e-51 -3.10286839785086 3.20941823581068e-24 miRNATAP -0.518383498002174 8.62940485369508e-13 NA NA NA hsa-let-7e-5p GPM6B 0.261471269338985 0.00191077095550257 -2.23343254430802 1.51570824751064e-39 miRNAWalker2_validate -0.294956154652224 5.04296724371224e-05 NA NA NA hsa-miR-141-3p GPM6B 2.99777540204168 1.26370498493024e-78 -2.23343254430802 1.51570824751064e-39 TargetScan;miRNATAP -0.245390711182634 7.50327373802732e-13 NA NA NA hsa-miR-200a-3p GPM6B 2.55218480823434 2.96135446816238e-51 -2.23343254430802 1.51570824751064e-39 miRNATAP -0.211572578694185 3.41175166606786e-10 NA NA NA hsa-miR-141-3p GPR12 2.99777540204168 1.26370498493024e-78 -3.79560506584807 2.0728894670608e-29 TargetScan -0.451302857669628 1.89197608475184e-11 NA NA NA hsa-miR-200b-3p GPR12 2.11744072703209 1.66710572104191e-43 -3.79560506584807 2.0728894670608e-29 mirMAP -0.211209868194258 0.00439373819949444 NA NA NA hsa-miR-200c-3p GPR12 2.07038651806183 6.84613386286599e-51 -3.79560506584807 2.0728894670608e-29 mirMAP -0.356607875159398 1.14452341863566e-05 NA NA NA hsa-miR-200b-3p GPR146 2.11744072703209 1.66710572104191e-43 -2.68788146464682 1.82253967407916e-104 TargetScan -0.366631077549983 1.54794588342979e-37 NA NA NA hsa-miR-200c-3p GPR146 2.07038651806183 6.84613386286599e-51 -2.68788146464682 1.82253967407916e-104 miRNATAP -0.489498767203954 2.80922447941582e-57 NA NA NA hsa-miR-141-3p GPR174 2.99777540204168 1.26370498493024e-78 -0.507026158628465 0.0307281737271767 TargetScan -0.184639515850209 5.01653974605598e-05 NA NA NA hsa-miR-200b-3p GPR180 2.11744072703209 1.66710572104191e-43 -0.419688671710059 4.52786653827531e-06 MirTarget -0.101528818679626 1.63749131202508e-07 NA NA NA hsa-miR-200b-3p GPRASP2 2.11744072703209 1.66710572104191e-43 -1.46110022232681 1.06931349502168e-53 MirTarget -0.18143118279187 7.24824069559743e-18 NA NA NA hsa-miR-200c-3p GPRASP2 2.07038651806183 6.84613386286599e-51 -1.46110022232681 1.06931349502168e-53 MirTarget -0.215737410728882 8.99657119648442e-21 NA NA NA hsa-miR-132-3p GPRC5A -0.0365213889238607 0.668598301088667 2.29322459083232 3.32756816030689e-35 mirMAP -0.442484961735712 1.29162645975562e-08 NA NA NA hsa-miR-141-3p GPRC5B 2.99777540204168 1.26370498493024e-78 -1.63910234589149 6.33269142418421e-39 mirMAP -0.227001607818957 1.38743014053449e-19 NA NA NA hsa-miR-200a-3p GPRC5B 2.55218480823434 2.96135446816238e-51 -1.63910234589149 6.33269142418421e-39 mirMAP -0.186081846741303 6.00471584593723e-14 NA NA NA hsa-let-7e-5p GPRIN2 0.261471269338985 0.00191077095550257 -1.2123336131336 7.16020898632495e-05 mirMAP -0.479164153613346 0.000128708047811525 NA NA NA hsa-miR-28-5p GRAMD1A -0.14267073663385 0.0497619246260571 1.10999274616443 2.6714856402589e-53 miRanda -0.111835566009971 0.00232890461745794 NA NA NA hsa-miR-28-5p GRAMD1C -0.14267073663385 0.0497619246260571 -0.696224877463089 2.42950429103508e-08 miRanda -0.175710217376617 0.00336197515953319 NA NA NA hsa-miR-141-3p GRAP2 2.99777540204168 1.26370498493024e-78 -0.397653992932544 0.0139807990551696 mirMAP -0.138508348654333 1.0102557093128e-05 NA NA NA hsa-miR-200a-3p GRAP2 2.55218480823434 2.96135446816238e-51 -0.397653992932544 0.0139807990551696 mirMAP -0.122937913930831 6.60870979530783e-05 NA NA NA hsa-miR-132-3p GREB1L -0.0365213889238607 0.668598301088667 0.207142282470471 0.417169039824842 mirMAP -0.466661001117185 5.82592992768793e-06 NA NA NA hsa-miR-200b-3p GREM2 2.11744072703209 1.66710572104191e-43 -2.65211306689938 8.60704393228989e-30 TargetScan -0.455558823157359 1.52824133267104e-19 NA NA NA hsa-miR-143-3p GRHL2 -1.23248181631499 4.74160976678504e-28 1.69249317105664 8.71708493554679e-30 MirTarget;miRNATAP -0.374034531417935 9.61865243446274e-17 NA NA NA hsa-miR-28-5p GRIA2 -0.14267073663385 0.0497619246260571 -1.22821710537384 0.00759618405734023 miRanda -0.972213489728838 8.80044759415615e-06 NA NA NA hsa-miR-145-5p GRIK4 -2.62703571936687 7.64402900188551e-88 0.897296904823413 0.000510899507719862 MirTarget -0.243102366046916 5.09967263486442e-05 NA NA NA hsa-miR-200b-3p GRIN2A 2.11744072703209 1.66710572104191e-43 -1.82536115377551 6.42782297852272e-17 TargetScan -0.266628421722217 1.32487494509074e-08 NA NA NA hsa-let-7e-5p GRIN3A 0.261471269338985 0.00191077095550257 -0.624865745424297 1.84453735336025e-10 miRNATAP -0.191382721185745 2.10179380838607e-06 NA NA NA hsa-miR-200b-3p GRK5 2.11744072703209 1.66710572104191e-43 -1.21175050643001 7.9828104448934e-42 TargetScan -0.199693982300283 7.93076453613617e-25 NA NA NA hsa-miR-141-3p GSN 2.99777540204168 1.26370498493024e-78 -2.23393150379953 1.72954577951929e-91 MirTarget -0.429152218739585 1.26954723595622e-88 NA NA NA hsa-miR-200a-3p GSN 2.55218480823434 2.96135446816238e-51 -2.23393150379953 1.72954577951929e-91 MirTarget -0.311256977660154 3.70009189291315e-44 NA NA NA hsa-miR-132-3p GSTCD -0.0365213889238607 0.668598301088667 0.519181234576788 2.42559606422446e-07 miRNAWalker2_validate -0.173937489459421 2.06686265546553e-05 NA NA NA hsa-miR-28-5p GSTCD -0.14267073663385 0.0497619246260571 0.519181234576788 2.42559606422446e-07 miRanda -0.273053868148414 1.15459678054143e-08 NA NA NA hsa-miR-28-5p GSTT2 -0.14267073663385 0.0497619246260571 -0.191330811443633 0.355850883029681 MirTarget;miRanda -0.220314719845183 0.0256737201615651 NA NA NA hsa-miR-200b-3p GUCY1A3 2.11744072703209 1.66710572104191e-43 -1.26223066041775 1.17870821628152e-20 TargetScan -0.200877890949908 5.08189961103363e-12 NA NA NA hsa-miR-132-3p GXYLT2 -0.0365213889238607 0.668598301088667 -0.0463175603061918 0.788135628617274 MirTarget -0.169712721884268 0.0150111948894137 NA NA NA hsa-miR-145-5p H2AFX -2.62703571936687 7.64402900188551e-88 1.9343631800414 6.58083947273181e-65 MirTarget;miRNATAP -0.385763991872566 5.21940074199578e-46 NA NA NA hsa-miR-141-3p HAS2 2.99777540204168 1.26370498493024e-78 -0.73254277727189 5.09218971882186e-05 MirTarget -0.39679145747752 1.7600904425533e-31 NA NA NA hsa-miR-200a-3p HAS2 2.55218480823434 2.96135446816238e-51 -0.73254277727189 5.09218971882186e-05 MirTarget -0.353512405426644 6.84947603905191e-26 NA NA NA hsa-miR-200b-3p HAS2 2.11744072703209 1.66710572104191e-43 -0.73254277727189 5.09218971882186e-05 TargetScan -0.381713491509829 2.09029477468797e-24 NA NA NA hsa-miR-200b-3p HCFC2 2.11744072703209 1.66710572104191e-43 -0.803119337578588 3.92380604887554e-30 TargetScan -0.147663931194614 1.23166442175703e-22 NA NA NA hsa-miR-200c-3p HCFC2 2.07038651806183 6.84613386286599e-51 -0.803119337578588 3.92380604887554e-30 miRNATAP -0.163766538126611 5.10038680592063e-23 NA NA NA hsa-miR-141-3p HDAC4 2.99777540204168 1.26370498493024e-78 -0.934609358419622 1.12652265115551e-31 TargetScan;miRNATAP -0.160502237044914 1.21270290273257e-24 NA NA NA hsa-miR-200a-3p HDAC4 2.55218480823434 2.96135446816238e-51 -0.934609358419622 1.12652265115551e-31 miRNATAP -0.111591573155961 8.74946122048941e-13 21837748 Furthermore our results suggested that the histone deacetylase 4 HDAC4 inhibited the expression of miR-200a and its promoter activity and reduced the histone H3 acetylation level at the mir-200a promoter through a Sp1-dependent pathway; Interestingly we observed that the miR-200a directly targeted the 3'-untranslated region of the HDAC4 messenger RNA and repressed expression of HDAC4; Through targeting HDAC4 miR-200a also induced the up-regulation of total acetyl-histone H3 levels and increased the histone H3 acetylation level at the p21WAF/Cip1 promoter; Our findings suggest that the HDAC4/Sp1/miR-200a regulatory network induces the down-regulation of miR-200a and the up-regulation of HDAC4 in HCC liver cancer hsa-miR-200b-3p HDAC4 2.11744072703209 1.66710572104191e-43 -0.934609358419622 1.12652265115551e-31 TargetScan -0.107002513608626 8.30409107669982e-10 NA NA NA hsa-miR-200c-3p HDAC4 2.07038651806183 6.84613386286599e-51 -0.934609358419622 1.12652265115551e-31 miRNATAP -0.172004226515195 9.63413369129246e-20 NA NA NA hsa-miR-141-3p HECW1 2.99777540204168 1.26370498493024e-78 -0.981727234424162 1.87120447192368e-07 TargetScan -0.186794162262921 3.55223020531038e-07 NA NA NA hsa-miR-200b-3p HECW2 2.11744072703209 1.66710572104191e-43 -0.358493289445225 0.00117705895738507 TargetScan -0.18386213114201 1.73022555715788e-15 NA NA NA hsa-miR-200b-3p HEG1 2.11744072703209 1.66710572104191e-43 -0.959876443317947 5.58216106035e-19 TargetScan -0.287685439750528 5.65747549286244e-38 NA NA NA hsa-miR-141-3p HGF 2.99777540204168 1.26370498493024e-78 -1.50227719275535 2.60659514703213e-20 MirTarget;TargetScan -0.460530345225581 6.82815824837891e-52 NA NA NA hsa-miR-200a-3p HGF 2.55218480823434 2.96135446816238e-51 -1.50227719275535 2.60659514703213e-20 MirTarget -0.395550183948552 6.66851532585504e-39 NA NA NA hsa-miR-28-5p HHAT -0.14267073663385 0.0497619246260571 0.644196417869949 1.52387006114795e-08 miRanda -0.377612142840797 2.72687205190048e-12 NA NA NA hsa-let-7e-5p HIF3A 0.261471269338985 0.00191077095550257 -5.27831973350434 1.81481983399704e-88 mirMAP -0.303419053084468 0.0122935140917873 NA NA NA hsa-miR-28-5p HIP1 -0.14267073663385 0.0497619246260571 -0.269049505601828 0.0114705315833163 MirTarget -0.112427420319756 0.0267792347282722 NA NA NA hsa-miR-141-3p HIPK3 2.99777540204168 1.26370498493024e-78 -1.48141194897483 7.96609771227689e-17 MirTarget;TargetScan -0.249329270801133 7.77789779889137e-13 NA NA NA hsa-miR-200a-3p HIPK3 2.55218480823434 2.96135446816238e-51 -1.48141194897483 7.96609771227689e-17 MirTarget -0.241709563697712 1.47010706104349e-12 NA NA NA hsa-miR-200b-3p HIPK3 2.11744072703209 1.66710572104191e-43 -1.48141194897483 7.96609771227689e-17 MirTarget;TargetScan -0.254884315698111 2.08715524349576e-11 NA NA NA hsa-miR-200c-3p HIPK3 2.07038651806183 6.84613386286599e-51 -1.48141194897483 7.96609771227689e-17 MirTarget -0.251079858804093 2.15324394786841e-09 NA NA NA hsa-miR-28-5p HK2 -0.14267073663385 0.0497619246260571 -0.0567451434395441 0.607921539997626 miRanda -0.2522359977272 1.46926915548621e-06 NA NA NA hsa-let-7e-5p HLF 0.261471269338985 0.00191077095550257 -3.73360626511854 1.05238992329545e-69 miRNATAP -0.351930221188109 0.000192179430569618 NA NA NA hsa-miR-141-3p HLF 2.99777540204168 1.26370498493024e-78 -3.73360626511854 1.05238992329545e-69 TargetScan -0.574632690101698 3.11279106663662e-41 NA NA NA hsa-miR-200b-3p HLF 2.11744072703209 1.66710572104191e-43 -3.73360626511854 1.05238992329545e-69 MirTarget;TargetScan -0.41260266276059 9.48573331809416e-18 NA NA NA hsa-miR-200c-3p HLF 2.07038651806183 6.84613386286599e-51 -3.73360626511854 1.05238992329545e-69 MirTarget;miRNATAP -0.548910593689306 9.52882721075114e-26 NA NA NA hsa-miR-200b-3p HMBOX1 2.11744072703209 1.66710572104191e-43 -0.729256061931685 4.98979109584954e-11 MirTarget;TargetScan -0.124645179291517 1.39616853319627e-07 NA NA NA hsa-miR-200c-3p HMBOX1 2.07038651806183 6.84613386286599e-51 -0.729256061931685 4.98979109584954e-11 MirTarget;miRNATAP -0.126429591630189 1.22747960113523e-06 NA NA NA hsa-miR-143-3p HMBS -1.23248181631499 4.74160976678504e-28 0.695146625649371 3.21237308552015e-19 MirTarget -0.125723587167081 6.87801661817828e-08 NA NA NA hsa-miR-143-3p HMGA1 -1.23248181631499 4.74160976678504e-28 1.5358410799772 5.78250243633113e-40 miRNATAP -0.243620386997253 8.72474517114013e-12 NA NA NA hsa-miR-28-5p HMGCL -0.14267073663385 0.0497619246260571 0.119677157715048 0.0987034936096925 miRanda -0.186094982487334 5.51594548336389e-08 NA NA NA hsa-miR-145-5p HN1L -2.62703571936687 7.64402900188551e-88 1.25611820070996 3.45460270418527e-58 mirMAP -0.200621439222817 2.88770713629468e-26 NA NA NA hsa-miR-141-3p HNMT 2.99777540204168 1.26370498493024e-78 -1.00611960537761 3.59848728302546e-29 TargetScan -0.222415586621322 5.01074473971309e-38 NA NA NA hsa-let-7e-5p HOXA1 0.261471269338985 0.00191077095550257 -1.00999705828073 6.8814503372889e-17 miRNATAP -0.183768884526733 0.000263592473632496 NA NA NA hsa-miR-141-3p HOXA11 2.99777540204168 1.26370498493024e-78 0.610518541755563 0.00131770850668378 TargetScan;miRNATAP -0.152235638281847 3.75602155268976e-05 NA NA NA hsa-miR-200a-3p HOXA11 2.55218480823434 2.96135446816238e-51 0.610518541755563 0.00131770850668378 miRNATAP -0.186921017890231 2.29686019657857e-07 NA NA NA hsa-miR-200b-3p HOXA5 2.11744072703209 1.66710572104191e-43 -3.01456089936248 1.31977175737153e-66 TargetScan -0.413077170984604 5.07618077905355e-26 NA NA NA hsa-let-7e-5p HOXA9 0.261471269338985 0.00191077095550257 -2.51701243665575 2.02680334794481e-43 miRNATAP -0.274174581749547 0.00048594949740261 NA NA NA hsa-miR-28-5p HOXB3 -0.14267073663385 0.0497619246260571 -0.0860590412997158 0.642417857654296 PITA;miRanda;miRNATAP -0.475202338351595 5.93635891671727e-08 NA NA NA hsa-miR-28-5p HOXB4 -0.14267073663385 0.0497619246260571 -0.561173445358375 0.0015867398646201 PITA -0.28245526601429 0.000857922940437544 NA NA NA hsa-miR-141-3p HOXB5 2.99777540204168 1.26370498493024e-78 0.302409356822888 0.214170316650101 miRNAWalker2_validate;TargetScan;miRNATAP -0.12785333431879 0.00689890084074076 NA NA NA hsa-miR-200b-3p HOXB5 2.11744072703209 1.66710572104191e-43 0.302409356822888 0.214170316650101 miRNAWalker2_validate -0.13052183114126 0.0115081039515208 NA NA NA hsa-miR-200c-3p HOXB5 2.07038651806183 6.84613386286599e-51 0.302409356822888 0.214170316650101 miRNAWalker2_validate -0.225962472200039 6.62396588937751e-05 NA NA NA hsa-miR-145-5p HOXC11 -2.62703571936687 7.64402900188551e-88 3.49353922396973 6.90770469505975e-25 miRNATAP -0.565054105800959 1.87369555690036e-12 NA NA NA hsa-miR-143-3p HRAS -1.23248181631499 4.74160976678504e-28 0.871315771945202 9.54693368299171e-15 miRNAWalker2_validate;miRTarBase -0.13171025180707 9.59955008801748e-05 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-141-3p HS3ST3B1 2.99777540204168 1.26370498493024e-78 0.124324849124971 0.453118013962469 mirMAP -0.115159307276079 0.000340251230207572 NA NA NA hsa-miR-200a-3p HS3ST3B1 2.55218480823434 2.96135446816238e-51 0.124324849124971 0.453118013962469 mirMAP -0.11527944617107 0.00025621972639607 NA NA NA hsa-miR-145-5p HS6ST1 -2.62703571936687 7.64402900188551e-88 0.788477247054106 1.86261413638323e-25 MirTarget;miRNATAP -0.194001835080178 1.41719502589613e-28 NA NA NA hsa-miR-132-3p HSPA12A -0.0365213889238607 0.668598301088667 -1.59429422829621 2.19664751982594e-36 MirTarget -0.160057917189444 0.00282327775278285 NA NA NA hsa-miR-141-3p HTR2A 2.99777540204168 1.26370498493024e-78 -3.25271640549639 1.50870378512719e-45 TargetScan -0.594628497011561 8.62716545110525e-40 NA NA NA hsa-miR-200b-3p HTR2A 2.11744072703209 1.66710572104191e-43 -3.25271640549639 1.50870378512719e-45 MirTarget -0.460179718567547 7.53887069674351e-20 NA NA NA hsa-miR-200c-3p HTR2A 2.07038651806183 6.84613386286599e-51 -3.25271640549639 1.50870378512719e-45 MirTarget -0.550786515734788 1.9952632069648e-23 NA NA NA hsa-miR-200b-3p HUNK 2.11744072703209 1.66710572104191e-43 -1.41437716129914 2.840058273601e-14 mirMAP -0.290741115563636 1.96858395645014e-13 NA NA NA hsa-miR-200c-3p HUNK 2.07038651806183 6.84613386286599e-51 -1.41437716129914 2.840058273601e-14 mirMAP -0.289605836490056 3.15184386672616e-11 NA NA NA hsa-miR-28-5p IER3 -0.14267073663385 0.0497619246260571 1.45642417730307 4.17853765486836e-24 miRanda -0.445532576838926 1.77892706208939e-10 NA NA NA hsa-miR-141-3p IFFO2 2.99777540204168 1.26370498493024e-78 -1.48770908138493 6.98625747312425e-36 MirTarget;TargetScan -0.125128329938908 1.93296816530002e-07 NA NA NA hsa-let-7e-5p IFI44L 0.261471269338985 0.00191077095550257 0.305092535286277 0.0949862560546626 MirTarget -0.158716542580816 0.0339017269694619 NA NA NA hsa-miR-141-3p IGDCC4 2.99777540204168 1.26370498493024e-78 -0.510415377148981 0.000190814880341201 TargetScan;miRNATAP -0.298483749014646 3.60076080217856e-31 NA NA NA hsa-miR-200a-3p IGDCC4 2.55218480823434 2.96135446816238e-51 -0.510415377148981 0.000190814880341201 miRNATAP -0.24365222055875 1.43769952394525e-21 NA NA NA hsa-miR-141-3p IGF2 2.99777540204168 1.26370498493024e-78 -1.80707502143834 9.64580354953106e-21 MirTarget;TargetScan -0.526450181465424 1.71357013794482e-47 NA NA NA hsa-miR-200a-3p IGF2 2.55218480823434 2.96135446816238e-51 -1.80707502143834 9.64580354953106e-21 MirTarget -0.43049563526396 2.80291025727271e-32 NA NA NA hsa-miR-205-5p IGF2BP1 -1.70057043266505 1.20976599540743e-09 2.12244186614741 1.81788912332828e-16 mirMAP -0.135123108677754 2.06137752564402e-05 NA NA NA hsa-miR-141-3p IGF2BP2 2.99777540204168 1.26370498493024e-78 -2.09056613546731 8.03883357755438e-21 MirTarget;TargetScan;miRNATAP -0.308964954035836 2.13564123840852e-12 NA NA NA hsa-miR-200a-3p IGF2BP2 2.55218480823434 2.96135446816238e-51 -2.09056613546731 8.03883357755438e-21 MirTarget;miRNATAP -0.253487183920497 4.95008082409817e-09 NA NA NA hsa-miR-200b-3p IGF2R 2.11744072703209 1.66710572104191e-43 -0.348661109166449 1.03155679185794e-05 MirTarget;TargetScan -0.13068413320337 3.00896491647488e-15 NA NA NA hsa-miR-200c-3p IGF2R 2.07038651806183 6.84613386286599e-51 -0.348661109166449 1.03155679185794e-05 MirTarget -0.129727939408734 1.26293466668871e-12 NA NA NA hsa-miR-200b-3p IGSF10 2.11744072703209 1.66710572104191e-43 -3.95227744371027 3.36497452938838e-68 MirTarget -0.635794894993236 6.65294331325235e-37 NA NA NA hsa-miR-200c-3p IGSF10 2.07038651806183 6.84613386286599e-51 -3.95227744371027 3.36497452938838e-68 MirTarget -0.719182726273409 3.59735727846842e-39 NA NA NA hsa-miR-28-5p IGSF9B -0.14267073663385 0.0497619246260571 -0.79264498666556 0.00225611443190345 PITA -0.831362938844611 1.14584744026297e-11 NA NA NA hsa-miR-28-5p IKBKAP -0.14267073663385 0.0497619246260571 0.0789492756746029 0.15612858735694 miRanda -0.118612871400018 6.65742475118864e-06 NA NA NA hsa-miR-28-5p IKBKB -0.14267073663385 0.0497619246260571 0.273066826249678 0.00234033685126725 miRanda -0.249159305195741 4.36298401628208e-09 NA NA NA hsa-miR-28-5p IL13RA1 -0.14267073663385 0.0497619246260571 0.0785365367680315 0.282318167449858 miRanda -0.146588109721817 2.29274382682583e-05 NA NA NA hsa-miR-141-3p IL18R1 2.99777540204168 1.26370498493024e-78 -0.690005437517726 7.21646874091323e-07 MirTarget -0.223862252764291 5.72319233427833e-17 NA NA NA hsa-miR-200a-3p IL18R1 2.55218480823434 2.96135446816238e-51 -0.690005437517726 7.21646874091323e-07 MirTarget -0.215151086528538 2.54766140173558e-16 NA NA NA hsa-let-7e-5p IL6R 0.261471269338985 0.00191077095550257 -1.4959681212526 3.98690474593025e-23 miRNATAP -0.17507204538523 0.00585557898341552 NA NA NA hsa-miR-141-3p IL6R 2.99777540204168 1.26370498493024e-78 -1.4959681212526 3.98690474593025e-23 MirTarget -0.253098258336402 1.27382588367647e-17 NA NA NA hsa-miR-200a-3p IL6R 2.55218480823434 2.96135446816238e-51 -1.4959681212526 3.98690474593025e-23 MirTarget -0.235380598297946 6.33404340334906e-16 NA NA NA hsa-miR-132-3p IL6ST -0.0365213889238607 0.668598301088667 -1.52737235369582 4.44388978309665e-09 mirMAP -0.274534343528062 0.00992386031490921 NA NA NA hsa-miR-200b-3p IL6ST 2.11744072703209 1.66710572104191e-43 -1.52737235369582 4.44388978309665e-09 TargetScan;mirMAP -0.261627924408914 2.44482742970634e-06 NA NA NA hsa-miR-200c-3p IL6ST 2.07038651806183 6.84613386286599e-51 -1.52737235369582 4.44388978309665e-09 mirMAP -0.317849621642354 1.84584384570656e-07 NA NA NA hsa-miR-28-5p IMPDH1 -0.14267073663385 0.0497619246260571 0.896084693787804 4.77040402047121e-25 miRNAWalker2_validate;MirTarget;PITA;miRanda;miRNATAP -0.101168477468638 0.0174266284653124 NA NA NA hsa-miR-28-5p INPP5J -0.14267073663385 0.0497619246260571 0.586361668320023 0.00503623021199427 miRanda -0.777616097841152 2.31907281894163e-15 NA NA NA hsa-miR-28-5p IQSEC2 -0.14267073663385 0.0497619246260571 0.43925999202862 1.87323493794481e-07 PITA;miRanda;miRNATAP -0.168166530507332 2.97911256467842e-05 NA NA NA hsa-miR-141-3p IRAK3 2.99777540204168 1.26370498493024e-78 -1.84214553446996 7.98016779710475e-32 mirMAP -0.395371091533372 5.07583894364656e-39 NA NA NA hsa-miR-200a-3p IRAK3 2.55218480823434 2.96135446816238e-51 -1.84214553446996 7.98016779710475e-32 mirMAP -0.318261128528154 5.73130945956319e-26 NA NA NA hsa-miR-200c-3p IRS1 2.07038651806183 6.84613386286599e-51 -1.09359999788168 5.90327201022502e-13 miRNATAP -0.176788257679081 7.61635995828395e-07 NA NA NA hsa-miR-141-3p IRS2 2.99777540204168 1.26370498493024e-78 -1.8204216908965 4.33851273349302e-35 MirTarget;TargetScan;miRNATAP -0.235924790553112 1.04773628002177e-15 27186273 Forced expression of IRS2 reversed the inhibition effect induced by miR-141 overexpression in thyroid cancer cells; Taken together our study provides the first evidence that miR-141 suppressed thyroid cancer cell growth and metastasis through inhibition of IRS2 metastasis thyroid cancer hsa-miR-200a-3p IRS2 2.55218480823434 2.96135446816238e-51 -1.8204216908965 4.33851273349302e-35 MirTarget;miRNATAP -0.175545744057414 1.60236179475126e-09 NA NA NA hsa-miR-28-5p ISCU -0.14267073663385 0.0497619246260571 -0.474318624658276 2.67102425402634e-20 miRanda -0.115854970892749 3.22684462403418e-06 NA NA NA hsa-miR-200b-3p ITGA1 2.11744072703209 1.66710572104191e-43 -1.29512393000353 7.98953749577455e-27 MirTarget -0.315620670948116 1.43489959453689e-35 NA NA NA hsa-miR-200c-3p ITGA1 2.07038651806183 6.84613386286599e-51 -1.29512393000353 7.98953749577455e-27 MirTarget -0.346757618979074 1.67421615105689e-35 NA NA NA hsa-miR-28-5p ITGA3 -0.14267073663385 0.0497619246260571 -0.299252352501844 0.0107499356635658 miRanda -0.36126889309902 6.72512700126372e-11 NA NA NA hsa-miR-200b-3p ITGA9 2.11744072703209 1.66710572104191e-43 -1.80608575406488 8.11052269984858e-33 mirMAP -0.296491785199914 1.27602275062816e-19 24518294;26334393 β1 integrin inhibition elicits a prometastatic switch through the TGFβ miR 200 ZEB network in E cadherin positive triple negative breast cancer;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ; breast cancer;esophageal cancer hsa-miR-141-3p ITGAV 2.99777540204168 1.26370498493024e-78 -0.0515028444394998 0.572303431365019 MirTarget -0.108251623223024 6.82325620061394e-10 NA NA NA hsa-miR-200a-3p ITGAV 2.55218480823434 2.96135446816238e-51 -0.0515028444394998 0.572303431365019 MirTarget -0.10013577528264 6.24202667621143e-09 NA NA NA hsa-miR-200b-3p ITM2B 2.11744072703209 1.66710572104191e-43 -0.774118134449479 1.44766521128185e-32 TargetScan -0.12915238374822 3.58954933480469e-20 NA NA NA hsa-miR-200b-3p ITPR1 2.11744072703209 1.66710572104191e-43 -1.46807554682214 2.21759203162078e-22 TargetScan -0.152946773039534 2.9772888212609e-06 NA NA NA hsa-miR-200c-3p ITPR1 2.07038651806183 6.84613386286599e-51 -1.46807554682214 2.21759203162078e-22 miRNATAP -0.183187577943365 3.48180608913953e-07 NA NA NA hsa-miR-141-3p ITSN1 2.99777540204168 1.26370498493024e-78 -1.54952456784757 2.98389839982187e-72 TargetScan;mirMAP -0.314671826600494 3.57030031689501e-80 NA NA NA hsa-miR-200a-3p ITSN1 2.55218480823434 2.96135446816238e-51 -1.54952456784757 2.98389839982187e-72 mirMAP -0.281702036352308 1.61598821068158e-64 NA NA NA hsa-miR-200b-3p ITSN1 2.11744072703209 1.66710572104191e-43 -1.54952456784757 2.98389839982187e-72 TargetScan -0.304186437686147 2.8057181100831e-60 NA NA NA hsa-miR-28-5p IVD -0.14267073663385 0.0497619246260571 -0.0240972756498818 0.810416205879283 miRanda -0.461574514514484 3.38114554736114e-23 NA NA NA hsa-miR-141-3p JAG1 2.99777540204168 1.26370498493024e-78 -0.639848689982383 1.267264807356e-11 TargetScan;miRNATAP -0.181143197005444 1.3218035421414e-23 NA NA NA hsa-miR-200a-3p JAG1 2.55218480823434 2.96135446816238e-51 -0.639848689982383 1.267264807356e-11 miRNATAP -0.158129060319048 8.46880611870666e-19 NA NA NA hsa-miR-200c-3p JAG1 2.07038651806183 6.84613386286599e-51 -0.639848689982383 1.267264807356e-11 miRNAWalker2_validate -0.198884904510323 7.69822940625124e-20 NA NA NA hsa-miR-141-3p JAZF1 2.99777540204168 1.26370498493024e-78 -0.923990464641291 4.60180562998007e-31 MirTarget;miRNATAP -0.218487624704801 5.75457071465146e-47 NA NA NA hsa-miR-200a-3p JAZF1 2.55218480823434 2.96135446816238e-51 -0.923990464641291 4.60180562998007e-31 MirTarget;miRNATAP -0.18737143018996 2.98029984108802e-35 NA NA NA hsa-miR-200b-3p JAZF1 2.11744072703209 1.66710572104191e-43 -0.923990464641291 4.60180562998007e-31 MirTarget;TargetScan -0.21708530697461 2.07737411492899e-38 NA NA NA hsa-miR-200c-3p JAZF1 2.07038651806183 6.84613386286599e-51 -0.923990464641291 4.60180562998007e-31 MirTarget;miRNATAP -0.274951933132508 3.73724958148104e-52 NA NA NA hsa-miR-28-5p JKAMP -0.14267073663385 0.0497619246260571 0.0735788909422048 0.22789285081931 miRanda -0.24997489116713 1.33099887959275e-18 NA NA NA hsa-miR-141-3p JMJD1C 2.99777540204168 1.26370498493024e-78 -0.953909284202117 8.88053084204105e-27 TargetScan;miRNATAP -0.112751286313442 1.87607549342718e-10 NA NA NA hsa-miR-200a-3p JMJD1C 2.55218480823434 2.96135446816238e-51 -0.953909284202117 8.88053084204105e-27 miRNATAP -0.101250305321967 5.88454545475261e-09 NA NA NA hsa-miR-145-5p JPH1 -2.62703571936687 7.64402900188551e-88 0.811793520985586 6.62203604379622e-06 miRNATAP -0.191870753350915 4.69666939147425e-06 NA NA NA hsa-miR-28-5p JPH3 -0.14267073663385 0.0497619246260571 1.09335026757806 1.5377591231963e-07 miRanda -0.259615856533199 0.00943315433708511 NA NA NA hsa-miR-141-3p JUN 2.99777540204168 1.26370498493024e-78 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.26513026030347 4.33514873445987e-29 NA NA NA hsa-miR-200a-3p JUN 2.55218480823434 2.96135446816238e-51 -1.36309173493779 4.05020743854001e-29 miRNATAP -0.179081800592841 4.16743748553287e-14 NA NA NA hsa-miR-200b-3p JUN 2.11744072703209 1.66710572104191e-43 -1.36309173493779 4.05020743854001e-29 MirTarget;TargetScan -0.16460620647419 5.28647088864828e-10 NA NA NA hsa-miR-200c-3p JUN 2.07038651806183 6.84613386286599e-51 -1.36309173493779 4.05020743854001e-29 MirTarget -0.273188681953389 1.78966606345752e-21 NA NA NA hsa-miR-200b-3p KANK1 2.11744072703209 1.66710572104191e-43 -2.04494589285398 6.14282151736161e-68 MirTarget;TargetScan -0.225785663199898 2.27973124550979e-17 NA NA NA hsa-miR-200c-3p KANK1 2.07038651806183 6.84613386286599e-51 -2.04494589285398 6.14282151736161e-68 MirTarget -0.286218542079834 7.16661498229372e-23 NA NA NA hsa-miR-200b-3p KANK2 2.11744072703209 1.66710572104191e-43 -1.03600021450898 6.97895190485011e-35 TargetScan -0.256075301106882 2.5573133116633e-48 NA NA NA hsa-miR-141-3p KATNAL1 2.99777540204168 1.26370498493024e-78 -1.08402942876846 2.5964427554243e-40 TargetScan -0.179120633203438 9.54814311548799e-29 NA NA NA hsa-miR-200b-3p KATNAL1 2.11744072703209 1.66710572104191e-43 -1.08402942876846 2.5964427554243e-40 TargetScan -0.166526030737014 6.59414644029876e-21 NA NA NA hsa-miR-141-3p KBTBD11 2.99777540204168 1.26370498493024e-78 -1.27376692325044 2.87674128531081e-17 mirMAP -0.239819158071957 3.26597000236233e-16 NA NA NA hsa-miR-200a-3p KBTBD11 2.55218480823434 2.96135446816238e-51 -1.27376692325044 2.87674128531081e-17 mirMAP -0.17839015729355 8.42036884486725e-10 NA NA NA hsa-miR-141-3p KBTBD12 2.99777540204168 1.26370498493024e-78 -2.56473508131234 3.31063468660652e-23 mirMAP -0.316006277653369 6.85294500975894e-10 NA NA NA hsa-miR-200a-3p KBTBD12 2.55218480823434 2.96135446816238e-51 -2.56473508131234 3.31063468660652e-23 mirMAP -0.202681504731449 6.14493330983586e-05 NA NA NA hsa-miR-132-3p KBTBD3 -0.0365213889238607 0.668598301088667 -0.676006524299838 3.2587187746144e-17 miRNAWalker2_validate -0.175161552215921 9.82281597954954e-08 NA NA NA hsa-miR-200b-3p KBTBD8 2.11744072703209 1.66710572104191e-43 -0.152883899138386 0.211626457945711 TargetScan -0.115034570561229 8.60173110524296e-06 NA NA NA hsa-miR-200b-3p KCNB1 2.11744072703209 1.66710572104191e-43 -4.37316589459594 1.02420393655674e-63 TargetScan -0.623588953822157 4.07261994602653e-27 NA NA NA hsa-miR-28-5p KCNC1 -0.14267073663385 0.0497619246260571 -0.419819323532828 0.125779819998908 mirMAP -0.530785569422823 4.62637322950816e-05 NA NA NA hsa-miR-200b-3p KCND2 2.11744072703209 1.66710572104191e-43 -0.620305038541618 0.00162583660129406 MirTarget;TargetScan -0.204468253791779 9.12381189810751e-07 NA NA NA hsa-miR-200c-3p KCND2 2.07038651806183 6.84613386286599e-51 -0.620305038541618 0.00162583660129406 MirTarget;miRNATAP -0.284518993527328 4.37799375142295e-10 NA NA NA hsa-miR-200b-3p KCND3 2.11744072703209 1.66710572104191e-43 -1.6472717356446 2.67019410294081e-09 TargetScan -0.137441407522222 0.0205533017958406 NA NA NA hsa-miR-200b-3p KCNJ15 2.11744072703209 1.66710572104191e-43 -0.303734766560402 0.0681241357503993 TargetScan -0.285598934224023 1.89308336458737e-16 NA NA NA hsa-miR-141-3p KCNJ2 2.99777540204168 1.26370498493024e-78 -1.76393304178556 8.52050444083173e-44 TargetScan;miRNATAP -0.289621474784258 1.18342323349976e-30 NA NA NA hsa-miR-200a-3p KCNJ2 2.55218480823434 2.96135446816238e-51 -1.76393304178556 8.52050444083173e-44 miRNATAP -0.248617389593586 1.96792443208591e-23 NA NA NA hsa-miR-200c-3p KCNJ2 2.07038651806183 6.84613386286599e-51 -1.76393304178556 8.52050444083173e-44 miRNATAP -0.310077839567584 2.33391462638397e-24 NA NA NA hsa-miR-200b-3p KCNJ5 2.11744072703209 1.66710572104191e-43 -0.50339272423311 0.000173297086610395 mirMAP -0.182101446053222 1.13536744007948e-10 NA NA NA hsa-miR-145-5p KCNK1 -2.62703571936687 7.64402900188551e-88 1.23868385128456 4.58194579660883e-07 MirTarget -0.186664813046343 0.00114733790742005 NA NA NA hsa-miR-200c-3p KCNK2 2.07038651806183 6.84613386286599e-51 -1.68436592750629 1.76729460831538e-11 miRNATAP -0.204359045556599 0.000544851110094652 NA NA NA hsa-miR-141-3p KCNK3 2.99777540204168 1.26370498493024e-78 -1.87434649845534 1.0138987640139e-12 mirMAP -0.28555606522472 2.9430046089366e-08 NA NA NA hsa-miR-200a-3p KCNK3 2.55218480823434 2.96135446816238e-51 -1.87434649845534 1.0138987640139e-12 mirMAP -0.245699609070965 1.21912707003098e-06 NA NA NA hsa-let-7e-5p KCNQ4 0.261471269338985 0.00191077095550257 -2.00601887339821 2.87129859849754e-16 miRNATAP -0.38037304812465 0.00019413855214364 NA NA NA hsa-miR-200b-3p KCNQ4 2.11744072703209 1.66710572104191e-43 -2.00601887339821 2.87129859849754e-16 TargetScan -0.141955010731346 0.00743752036550139 NA NA NA hsa-miR-200c-3p KCNQ4 2.07038651806183 6.84613386286599e-51 -2.00601887339821 2.87129859849754e-16 miRNATAP -0.190328987151245 0.0010873660280215 NA NA NA hsa-miR-141-3p KCNS1 2.99777540204168 1.26370498493024e-78 -2.5665698830388 6.59105430153009e-22 MirTarget -0.203893593164262 0.000124821160923031 NA NA NA hsa-miR-200a-3p KCNS1 2.55218480823434 2.96135446816238e-51 -2.5665698830388 6.59105430153009e-22 MirTarget -0.169241275502829 0.00118792811199734 NA NA NA hsa-miR-141-3p KCTD12 2.99777540204168 1.26370498493024e-78 -1.79741890724673 5.41613909344923e-64 TargetScan -0.386399966248061 4.29274054998861e-81 NA NA NA hsa-miR-141-3p KCTD20 2.99777540204168 1.26370498493024e-78 -0.522937645404041 1.61102511851964e-09 MirTarget;TargetScan -0.129086405249865 1.26544996794066e-14 NA NA NA hsa-miR-200a-3p KCTD20 2.55218480823434 2.96135446816238e-51 -0.522937645404041 1.61102511851964e-09 MirTarget -0.136624229999009 7.34524934292875e-17 NA NA NA hsa-miR-200b-3p KDELC1 2.11744072703209 1.66710572104191e-43 0.366480476505469 2.94820022889719e-05 TargetScan -0.106018057883402 1.06495649855796e-08 NA NA NA hsa-miR-28-5p KDM4B -0.14267073663385 0.0497619246260571 1.06513960289204 1.83172415682094e-18 mirMAP -0.540037157578679 8.74735536906072e-21 NA NA NA hsa-miR-200b-3p KDR 2.11744072703209 1.66710572104191e-43 -1.26178488366313 1.81783097872036e-35 miRNAWalker2_validate;miRTarBase;TargetScan -0.262999260406618 3.87053169124588e-34 NA NA NA hsa-miR-200c-3p KDR 2.07038651806183 6.84613386286599e-51 -1.26178488366313 1.81783097872036e-35 miRNATAP -0.289279648433676 3.71227459751374e-34 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-141-3p KHDRBS3 2.99777540204168 1.26370498493024e-78 -0.535630864859294 7.93502963529463e-05 TargetScan -0.114811590775896 1.35984636024326e-05 NA NA NA hsa-miR-28-5p KIAA0100 -0.14267073663385 0.0497619246260571 -0.0958458902820514 0.226748853303652 miRanda -0.103750602698321 0.00593347169014391 NA NA NA hsa-miR-28-5p KIAA0319L -0.14267073663385 0.0497619246260571 0.399937221728762 2.70410247773894e-07 miRanda -0.290985152725794 2.02934336200034e-15 NA NA NA hsa-miR-200b-3p KIAA0355 2.11744072703209 1.66710572104191e-43 -0.839888715749088 9.49359998690135e-39 MirTarget;TargetScan -0.135205848762749 3.9596829960545e-22 NA NA NA hsa-miR-200c-3p KIAA0355 2.07038651806183 6.84613386286599e-51 -0.839888715749088 9.49359998690135e-39 MirTarget;miRNATAP -0.182248207560121 2.38493415764389e-33 NA NA NA hsa-miR-141-3p KIAA0408 2.99777540204168 1.26370498493024e-78 -6.77635661274003 2.35177949256626e-67 MirTarget;TargetScan -1.11313326407261 5.83832643432176e-46 NA NA NA hsa-miR-200a-3p KIAA0408 2.55218480823434 2.96135446816238e-51 -6.77635661274003 2.35177949256626e-67 MirTarget -0.900567775449332 1.28785235564081e-30 NA NA NA hsa-let-7e-5p KIAA1147 0.261471269338985 0.00191077095550257 -0.158933472642647 0.0497245616877274 miRNATAP -0.125397217388749 0.000147136690849103 NA NA NA hsa-miR-28-5p KIAA1328 -0.14267073663385 0.0497619246260571 -0.669584991112985 6.66171801821041e-21 miRanda -0.101475073882874 0.00354775169440602 NA NA NA hsa-miR-200b-3p KIAA1462 2.11744072703209 1.66710572104191e-43 -0.894733095554471 4.07536183567301e-18 MirTarget;TargetScan -0.299581326367512 1.05038038536135e-45 NA NA NA hsa-miR-200c-3p KIAA1462 2.07038651806183 6.84613386286599e-51 -0.894733095554471 4.07536183567301e-18 MirTarget -0.360336870412728 1.02794865002582e-55 NA NA NA hsa-miR-141-3p KIAA1644 2.99777540204168 1.26370498493024e-78 1.06971961713243 5.04812834911815e-08 mirMAP -0.131056028002902 0.000647223239205563 NA NA NA hsa-miR-200a-3p KIAA1644 2.55218480823434 2.96135446816238e-51 1.06971961713243 5.04812834911815e-08 mirMAP -0.126703776769301 0.000776790179926012 NA NA NA hsa-miR-141-3p KIDINS220 2.99777540204168 1.26370498493024e-78 -0.670641230766213 1.2866423600809e-18 MirTarget -0.10605737052898 1.17837005909692e-12 NA NA NA hsa-miR-200b-3p KIF13A 2.11744072703209 1.66710572104191e-43 -1.04466955177769 2.78344291551554e-23 TargetScan -0.153427787254806 1.2798883776369e-11 NA NA NA hsa-miR-200c-3p KIF13A 2.07038651806183 6.84613386286599e-51 -1.04466955177769 2.78344291551554e-23 miRNATAP -0.161862432993178 8.65708015869743e-11 NA NA NA hsa-miR-28-5p KIF13B -0.14267073663385 0.0497619246260571 -0.34768873706652 0.0092559287339681 mirMAP -0.434610126797026 5.07804987181791e-12 NA NA NA hsa-miR-141-3p KIF17 2.99777540204168 1.26370498493024e-78 -1.17633998273391 1.64922956013024e-24 MirTarget;TargetScan -0.278930798555516 1.08395669606161e-36 NA NA NA hsa-miR-200a-3p KIF17 2.55218480823434 2.96135446816238e-51 -1.17633998273391 1.64922956013024e-24 MirTarget -0.190472945042861 8.74801717127724e-18 NA NA NA hsa-miR-141-3p KIF1C 2.99777540204168 1.26370498493024e-78 -0.530841519866912 2.45227404770519e-10 TargetScan;miRNATAP -0.132112310756655 3.22777417111317e-16 NA NA NA hsa-miR-145-5p KIF21A -2.62703571936687 7.64402900188551e-88 0.555528333264837 1.30981034336941e-06 MirTarget -0.103858933309768 0.000104432263131849 NA NA NA hsa-let-7e-5p KIF21B 0.261471269338985 0.00191077095550257 0.141435577063637 0.284077704521929 mirMAP;miRNATAP -0.13861569155782 0.0102451800253473 NA NA NA hsa-miR-143-3p KIF3B -1.23248181631499 4.74160976678504e-28 0.283544990227211 2.21110051429036e-05 MirTarget;miRNATAP -0.137964274223612 1.87026420614897e-12 NA NA NA hsa-miR-143-3p KLC2 -1.23248181631499 4.74160976678504e-28 1.1468056186047 2.10983792785086e-40 miRNATAP -0.235410404425725 2.89399998802996e-19 NA NA NA hsa-miR-28-5p KLC2 -0.14267073663385 0.0497619246260571 1.1468056186047 2.10983792785086e-40 mirMAP -0.215545188517003 5.1082835416341e-07 NA NA NA hsa-miR-200b-3p KLF10 2.11744072703209 1.66710572104191e-43 -1.2822855310566 4.0104075488289e-48 TargetScan -0.189252911541944 1.08405832707164e-22 NA NA NA hsa-miR-200c-3p KLF10 2.07038651806183 6.84613386286599e-51 -1.2822855310566 4.0104075488289e-48 miRNATAP -0.230832467793711 6.69153156560086e-28 NA NA NA hsa-miR-141-3p KLF11 2.99777540204168 1.26370498493024e-78 -1.36252050722545 2.98418037545873e-64 miRNAWalker2_validate;MirTarget -0.18130465417437 2.09390327369665e-28 NA NA NA hsa-miR-200a-3p KLF11 2.55218480823434 2.96135446816238e-51 -1.36252050722545 2.98418037545873e-64 miRNAWalker2_validate;MirTarget -0.172554627390354 1.02405720032334e-26 NA NA NA hsa-miR-200b-3p KLF11 2.11744072703209 1.66710572104191e-43 -1.36252050722545 2.98418037545873e-64 miRNAWalker2_validate -0.18136928772325 7.25506007385319e-24 NA NA NA hsa-miR-200c-3p KLF11 2.07038651806183 6.84613386286599e-51 -1.36252050722545 2.98418037545873e-64 miRNAWalker2_validate -0.189720595439794 1.24875216845081e-21 NA NA NA hsa-miR-141-3p KLF12 2.99777540204168 1.26370498493024e-78 -0.576392780554785 7.57826311599842e-09 MirTarget;TargetScan -0.138931546631831 6.15163752260048e-13 NA NA NA hsa-miR-200a-3p KLF12 2.55218480823434 2.96135446816238e-51 -0.576392780554785 7.57826311599842e-09 MirTarget -0.129448001103677 8.82064318817135e-12 NA NA NA hsa-miR-200b-3p KLF12 2.11744072703209 1.66710572104191e-43 -0.576392780554785 7.57826311599842e-09 TargetScan -0.125641595834132 2.92564413860313e-09 NA NA NA hsa-miR-200b-3p KLF13 2.11744072703209 1.66710572104191e-43 -0.896526705579424 4.61689653388107e-25 TargetScan -0.151619015169813 3.83036641768317e-16 NA NA NA hsa-miR-200c-3p KLF13 2.07038651806183 6.84613386286599e-51 -0.896526705579424 4.61689653388107e-25 miRNATAP -0.189663866602219 1.16555499886551e-20 NA NA NA hsa-miR-141-3p KLF3 2.99777540204168 1.26370498493024e-78 -0.554330026163965 2.9251145288686e-18 TargetScan;miRNATAP -0.100101247685112 6.71674927617038e-16 NA NA NA hsa-miR-200b-3p KLF3 2.11744072703209 1.66710572104191e-43 -0.554330026163965 2.9251145288686e-18 TargetScan -0.107765949016648 1.67792671471536e-15 NA NA NA hsa-miR-200b-3p KLF4 2.11744072703209 1.66710572104191e-43 -2.5658507723861 1.98241408884064e-67 MirTarget;TargetScan -0.318241517505975 1.36421966013675e-21 NA NA NA hsa-miR-200c-3p KLF4 2.07038651806183 6.84613386286599e-51 -2.5658507723861 1.98241408884064e-67 MirTarget;miRNATAP -0.480814879410328 2.74192522750191e-41 NA NA NA hsa-miR-141-3p KLF6 2.99777540204168 1.26370498493024e-78 -1.37238104447323 3.37677087181227e-49 TargetScan;miRNATAP -0.237924982832484 2.13952760808872e-38 NA NA NA hsa-miR-200a-3p KLF6 2.55218480823434 2.96135446816238e-51 -1.37238104447323 3.37677087181227e-49 miRNATAP -0.18060201182069 9.18714885970041e-23 NA NA NA hsa-miR-200b-3p KLF6 2.11744072703209 1.66710572104191e-43 -1.37238104447323 3.37677087181227e-49 TargetScan -0.186959282760515 8.66769270253547e-20 NA NA NA hsa-let-7e-5p KLF8 0.261471269338985 0.00191077095550257 -1.47188476442057 5.81400441959106e-30 miRNATAP -0.277280195893366 3.87015594551914e-07 NA NA NA hsa-miR-200b-3p KLF9 2.11744072703209 1.66710572104191e-43 -1.7429680316518 2.98275437403582e-61 TargetScan -0.288389907976558 1.45294640545342e-35 NA NA NA hsa-miR-200c-3p KLF9 2.07038651806183 6.84613386286599e-51 -1.7429680316518 2.98275437403582e-61 miRNAWalker2_validate;miRTarBase;miRNATAP -0.370308003675866 1.40559263229779e-49 NA NA NA hsa-miR-200b-3p KLHDC1 2.11744072703209 1.66710572104191e-43 -1.46137956613172 3.5740269082987e-32 MirTarget -0.136360362470307 5.20917344564022e-07 NA NA NA hsa-miR-200c-3p KLHDC1 2.07038651806183 6.84613386286599e-51 -1.46137956613172 3.5740269082987e-32 MirTarget -0.248383408918845 3.59899398143029e-17 NA NA NA hsa-miR-28-5p KLHL12 -0.14267073663385 0.0497619246260571 0.529262424359425 8.20108802188939e-16 miRNAWalker2_validate -0.149641356268714 2.33277459558367e-06 NA NA NA hsa-let-7e-5p KLHL13 0.261471269338985 0.00191077095550257 -3.1871504639887 4.77445821811942e-53 MirTarget;miRNATAP -0.353879605251277 9.62999910726061e-05 NA NA NA hsa-miR-200b-3p KLHL14 2.11744072703209 1.66710572104191e-43 -1.45187804996542 1.55252493201745e-11 TargetScan -0.266076405561841 6.78861893954895e-09 NA NA NA hsa-miR-141-3p KLHL20 2.99777540204168 1.26370498493024e-78 -0.580940687803831 3.29734241071236e-18 miRNAWalker2_validate -0.131933278614168 1.09740859260953e-24 NA NA NA hsa-miR-200a-3p KLHL20 2.55218480823434 2.96135446816238e-51 -0.580940687803831 3.29734241071236e-18 miRNAWalker2_validate -0.126435474737735 1.458203736018e-23 NA NA NA hsa-miR-200b-3p KLHL20 2.11744072703209 1.66710572104191e-43 -0.580940687803831 3.29734241071236e-18 miRNAWalker2_validate -0.135017451194605 9.47763581851314e-22 NA NA NA hsa-miR-200c-3p KLHL20 2.07038651806183 6.84613386286599e-51 -0.580940687803831 3.29734241071236e-18 miRNAWalker2_validate -0.159871356307668 3.57478729778656e-25 NA NA NA hsa-miR-200b-3p KLHL29 2.11744072703209 1.66710572104191e-43 -2.95396942574741 6.38249769037222e-85 MirTarget -0.376077414884347 1.59043473219451e-27 NA NA NA hsa-miR-200c-3p KLHL29 2.07038651806183 6.84613386286599e-51 -2.95396942574741 6.38249769037222e-85 MirTarget -0.489121323686625 6.23215473827391e-39 NA NA NA hsa-miR-200b-3p KLHL3 2.11744072703209 1.66710572104191e-43 -1.42904846118913 3.36735011519996e-41 TargetScan;mirMAP -0.233013166053113 5.92243783156719e-24 NA NA NA hsa-miR-200c-3p KLHL3 2.07038651806183 6.84613386286599e-51 -1.42904846118913 3.36735011519996e-41 miRNATAP -0.319582667624024 1.31441831100076e-37 NA NA NA hsa-let-7e-5p KLHL31 0.261471269338985 0.00191077095550257 -3.31721362350133 3.07495007926235e-88 MirTarget -0.216919619786776 0.0044114028897183 NA NA NA hsa-miR-200b-3p KLHL31 2.11744072703209 1.66710572104191e-43 -3.31721362350133 3.07495007926235e-88 MirTarget -0.403909945569104 5.90542127089379e-26 NA NA NA hsa-miR-200c-3p KLHL31 2.07038651806183 6.84613386286599e-51 -3.31721362350133 3.07495007926235e-88 MirTarget -0.499613453352171 5.6505973633548e-33 NA NA NA hsa-let-7e-5p KLHL6 0.261471269338985 0.00191077095550257 0.345337661033379 0.00772530971984598 miRNATAP -0.168436770622905 0.00149731447726819 NA NA NA hsa-let-7e-5p KLK10 0.261471269338985 0.00191077095550257 -2.24072052209129 1.86670067043124e-08 MirTarget -0.536435823004303 0.00109306564540724 NA NA NA hsa-miR-143-3p KRAS -1.23248181631499 4.74160976678504e-28 0.46818988509622 3.00748217900386e-10 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.124135749972866 1.80319700574441e-08 22804917;27725862;19137007;26581910;23173124;26824186;21197560 In KRAS mutated tumours increased miR-200b and decreased miR-143 expression were associated with a good PFS;The expression of miR-143 is often down-regulated and it might play an important role by targeting KRAS in colorectal cancer CRC; Dual-luciferase reporter assays were performed to validate whether KRAS was regulated by miR-143; Dual-luciferase assays indicated that KRAS was a direct target of miR-143 as subsequently demonstrated by qPCR and western blot analysis showing that infection of SW480 cells with Ad-ZD55-miR-143 resulted in the down-regulation of KRAS at both mRNA and protein levels;Role of miR 143 targeting KRAS in colorectal tumorigenesis; In particular among a panel of presumed targets generated by in silico analysis that may interact with these aberrantly expressed miRNAs KRAS oncogene has been further experimentally validated as the target of miR-143; First an inverse correlation between KRAS protein and miR-143 in vivo was found; Second KRAS expression in Lovo cells was significantly abolished by treatment with miR-143 mimic whereas miR-143 inhibitor increased KRAS protein level; Third luciferase reporter assay confirmed that miR-143 directly recognize the 3'-untranslated region of KRAS transcripts; Finally inhibition of KRAS expression by miR-143 inhibits constitutive phosphorylation of ERK1/2; Taken together the present study provides the first evidences that miR-143 is significant in suppressing colorectal cancer cell growth through inhibition of KRAS translation;MicroRNA 143 replenishment re sensitizes colorectal cancer cells harboring mutant but not wild type KRAS to paclitaxel treatment; Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS; Combination of miR-143 mimic and paclitaxel induced the onset of apoptosis and reverted in vitro metastatic properties migration and invasion in KRAS mutant tumor cells; MiR-143 thus can be used as a chemosensitizer for the treatment of KRAS mutant tumors and warrants further investigations in in vitro and pre-clinical in vivo models;In turn the level of miR-143 in CRC cells decreasing the amount of MACC1 metastasis-associated in colon cancer-1 and oncogenic KRAS protein may be utilized as a prognostic marker;Stable miR-143 or miR-145 overexpression increased cell sensitivity to cetuximab resulting in a significant increase of cetuximab-mediated ADCC independently of KRAS status;miR 143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS; The expression level of miR-143 and its target gene KRAS were measured by realtime PCR and western blotting respectively; Our results revealed an inverse correlation of expression between miR-143 and KRAS protein in prostate cancer samples Pearson's correlation scatter plots: R = -0.707 P < 0.05; These findings suggest that miR-143 plays an important role in prostate cancer proliferation migration and chemosensitivity by suppressing KRAS and subsequent inactivation of MAPK pathway which provides a potential development of a new approach for the treatment of prostate cancer ;;tumorigenesis;;metastasis;; colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colon cancer;prostate cancer hsa-miR-28-5p KRT1 -0.14267073663385 0.0497619246260571 -0.777638722715821 0.00784390063724915 miRanda -0.587015506653331 2.44860809440113e-05 NA NA NA hsa-miR-200a-3p KSR1 2.55218480823434 2.96135446816238e-51 -0.85900089733364 7.21800600691212e-18 mirMAP -0.165442564406279 3.52469026490611e-18 NA NA NA hsa-miR-200b-3p KSR1 2.11744072703209 1.66710572104191e-43 -0.85900089733364 7.21800600691212e-18 TargetScan;mirMAP -0.179057737932812 2.93994721904487e-17 NA NA NA hsa-miR-200c-3p KSR1 2.07038651806183 6.84613386286599e-51 -0.85900089733364 7.21800600691212e-18 mirMAP -0.20351754656324 2.21229417566801e-18 NA NA NA hsa-miR-132-3p KSR2 -0.0365213889238607 0.668598301088667 -0.0859402107200666 0.658608084265407 mirMAP;miRNATAP -0.192738669216254 0.0143928731154015 NA NA NA hsa-miR-28-5p L2HGDH -0.14267073663385 0.0497619246260571 0.278240981720089 0.00050935264456272 miRanda -0.151525232157627 6.96875931303208e-05 NA NA NA hsa-miR-200b-3p LAMC1 2.11744072703209 1.66710572104191e-43 -1.22673201326814 1.35102621663939e-35 MirTarget;TargetScan -0.289967230006364 9.75181041203852e-45 NA NA NA hsa-miR-200c-3p LAMC1 2.07038651806183 6.84613386286599e-51 -1.22673201326814 1.35102621663939e-35 MirTarget;miRNATAP -0.329360689529761 5.25538223517216e-48 NA NA NA hsa-miR-143-3p LARP4 -1.23248181631499 4.74160976678504e-28 0.342395135866956 1.01881181652413e-06 MirTarget;miRNATAP -0.134467114953727 6.84091031218482e-11 NA NA NA hsa-miR-143-3p LASP1 -1.23248181631499 4.74160976678504e-28 0.510957650421943 7.07992388247007e-09 MirTarget;miRNATAP -0.117356199301045 7.72139310980558e-06 NA NA NA hsa-miR-200c-3p LATS1 2.07038651806183 6.84613386286599e-51 -0.990266110404731 6.58107345321622e-13 miRNATAP -0.129530797506882 6.79149629055103e-05 NA NA NA hsa-miR-200b-3p LATS2 2.11744072703209 1.66710572104191e-43 -1.07930752603412 1.77477579396165e-33 TargetScan -0.242433743681395 1.08648777794347e-37 NA NA NA hsa-miR-200c-3p LATS2 2.07038651806183 6.84613386286599e-51 -1.07930752603412 1.77477579396165e-33 miRNATAP -0.293619037542608 2.39755570299602e-46 NA NA NA hsa-let-7e-5p LBH 0.261471269338985 0.00191077095550257 -0.445260882425265 1.92194045196989e-07 miRNATAP -0.132582946967994 0.000160493880901215 NA NA NA hsa-let-7e-5p LBR 0.261471269338985 0.00191077095550257 -0.401779315698072 8.08554841411615e-05 MirTarget -0.113975508989004 0.0064336131849848 NA NA NA hsa-miR-200b-3p LBR 2.11744072703209 1.66710572104191e-43 -0.401779315698072 8.08554841411615e-05 MirTarget;TargetScan -0.115039708464663 9.46590658535492e-08 NA NA NA hsa-miR-200c-3p LBR 2.07038651806183 6.84613386286599e-51 -0.401779315698072 8.08554841411615e-05 MirTarget -0.102925368746776 1.49376510315715e-05 NA NA NA hsa-miR-200b-3p LCA5 2.11744072703209 1.66710572104191e-43 -1.52780832675301 1.59946395741852e-39 MirTarget;TargetScan -0.18891853841453 1.33170333214429e-13 NA NA NA hsa-miR-200c-3p LCA5 2.07038651806183 6.84613386286599e-51 -1.52780832675301 1.59946395741852e-39 MirTarget -0.236335642432034 2.59700880600913e-17 NA NA NA hsa-miR-28-5p LDB3 -0.14267073663385 0.0497619246260571 -1.85025183125106 1.91109961605668e-38 miRanda -0.156357444186515 0.0284689138796435 NA NA NA hsa-miR-132-3p LFNG -0.0365213889238607 0.668598301088667 0.521997841611332 0.000590979407991039 miRNAWalker2_validate -0.182027871244963 0.00315968521458827 NA NA NA hsa-miR-28-5p LGALS3BP -0.14267073663385 0.0497619246260571 0.544528838581662 2.02239321559147e-06 mirMAP -0.12171697921316 0.0267154534109923 NA NA NA hsa-miR-143-3p LGALS8 -1.23248181631499 4.74160976678504e-28 0.363964932189037 3.61117065835098e-05 mirMAP -0.122026605290759 2.80702655035899e-06 NA NA NA hsa-miR-28-5p LGALS8 -0.14267073663385 0.0497619246260571 0.363964932189037 3.61117065835098e-05 mirMAP -0.163481869805943 9.97006315336776e-05 NA NA NA hsa-miR-141-3p LGR4 2.99777540204168 1.26370498493024e-78 -1.80154760191776 1.78479409180551e-31 MirTarget -0.264897230344887 4.65652574443527e-18 NA NA NA hsa-miR-200a-3p LGR4 2.55218480823434 2.96135446816238e-51 -1.80154760191776 1.78479409180551e-31 MirTarget -0.209678681673349 4.11420862464218e-12 NA NA NA hsa-miR-141-3p LHFP 2.99777540204168 1.26370498493024e-78 -2.16259674677525 1.67757586200326e-80 MirTarget -0.477450630254742 4.1465893838156e-111 NA NA NA hsa-miR-200a-3p LHFP 2.55218480823434 2.96135446816238e-51 -2.16259674677525 1.67757586200326e-80 MirTarget -0.381959827138675 6.75463351007796e-67 NA NA NA hsa-miR-200b-3p LHFP 2.11744072703209 1.66710572104191e-43 -2.16259674677525 1.67757586200326e-80 MirTarget;TargetScan -0.394555356349039 1.80094021057247e-56 NA NA NA hsa-miR-200c-3p LHFP 2.07038651806183 6.84613386286599e-51 -2.16259674677525 1.67757586200326e-80 MirTarget;miRNATAP -0.506967020020484 2.61318210948237e-81 NA NA NA hsa-miR-141-3p LHX6 2.99777540204168 1.26370498493024e-78 -1.95178533559281 6.99624188227914e-45 MirTarget;TargetScan;miRNATAP -0.345799790693977 9.78708001789682e-37 NA NA NA hsa-miR-200a-3p LHX6 2.55218480823434 2.96135446816238e-51 -1.95178533559281 6.99624188227914e-45 MirTarget;miRNATAP -0.282409210833886 3.04283998577957e-25 NA NA NA hsa-miR-141-3p LIF 2.99777540204168 1.26370498493024e-78 -0.905887057866458 4.87585212725247e-08 mirMAP -0.209274341605771 8.13949251394338e-11 NA NA NA hsa-miR-200a-3p LIF 2.55218480823434 2.96135446816238e-51 -0.905887057866458 4.87585212725247e-08 mirMAP -0.141099841954999 9.16221284800043e-06 NA NA NA hsa-miR-141-3p LIMCH1 2.99777540204168 1.26370498493024e-78 -1.49698446901643 1.67451218303074e-25 MirTarget -0.285198178764424 1.94884171624795e-24 NA NA NA hsa-miR-200a-3p LIMCH1 2.55218480823434 2.96135446816238e-51 -1.49698446901643 1.67451218303074e-25 MirTarget -0.259449235149436 4.6308015188002e-21 NA NA NA hsa-miR-143-3p LIMD1 -1.23248181631499 4.74160976678504e-28 0.312071976111651 1.36939590396432e-06 mirMAP -0.104285528664699 4.56578294005925e-08 NA NA NA hsa-miR-200b-3p LIX1L 2.11744072703209 1.66710572104191e-43 -1.12191838165483 1.88841382470153e-38 MirTarget -0.256581363994834 3.9895838092601e-45 NA NA NA hsa-miR-200c-3p LIX1L 2.07038651806183 6.84613386286599e-51 -1.12191838165483 1.88841382470153e-38 MirTarget -0.319830545669049 1.33157789728019e-59 NA NA NA hsa-miR-28-5p LMBR1 -0.14267073663385 0.0497619246260571 0.257517541171637 0.000199666000515199 MirTarget;miRanda -0.108414415821819 0.00101794134974501 NA NA NA hsa-miR-141-3p LMO3 2.99777540204168 1.26370498493024e-78 -2.66323880191004 4.12753530011824e-26 MirTarget;TargetScan -0.287667089187095 1.00382042979226e-08 NA NA NA hsa-miR-200a-3p LMO3 2.55218480823434 2.96135446816238e-51 -2.66323880191004 4.12753530011824e-26 MirTarget -0.268317355069568 5.25443338994674e-08 NA NA NA hsa-miR-141-3p LMOD3 2.99777540204168 1.26370498493024e-78 -0.439617445770009 0.0129847801223693 miRNATAP -0.108064708361408 0.00168942549546329 NA NA NA hsa-miR-132-3p LMX1B -0.0365213889238607 0.668598301088667 0.889964138391244 7.40589152986158e-06 mirMAP -0.312449523484139 0.000107264713816984 NA NA NA hsa-miR-200b-3p LNPEP 2.11744072703209 1.66710572104191e-43 -0.989631439347203 8.70205363760698e-12 mirMAP -0.221281418752689 6.13972471409315e-13 NA NA NA hsa-miR-200c-3p LNPEP 2.07038651806183 6.84613386286599e-51 -0.989631439347203 8.70205363760698e-12 mirMAP -0.207461171988358 9.93945764825925e-10 NA NA NA hsa-miR-200b-3p LOX 2.11744072703209 1.66710572104191e-43 -0.342212996476533 0.0205578562983786 TargetScan -0.302299111361363 4.30683884623164e-23 NA NA NA hsa-miR-132-3p LOXL1 -0.0365213889238607 0.668598301088667 1.49728597567933 5.44851508051121e-34 miRNAWalker2_validate -0.143121659688974 0.00594006063295867 NA NA NA hsa-miR-200b-3p LPAR1 2.11744072703209 1.66710572104191e-43 -1.20736956265381 1.93522163393847e-21 MirTarget;TargetScan -0.30751425904766 7.7026883287757e-31 NA NA NA hsa-miR-200c-3p LPAR1 2.07038651806183 6.84613386286599e-51 -1.20736956265381 1.93522163393847e-21 miRNAWalker2_validate;MirTarget;miRNATAP -0.351153536982569 2.48589736261259e-33 NA NA NA hsa-miR-143-3p LPAR2 -1.23248181631499 4.74160976678504e-28 1.45482613879136 2.4402475071835e-52 miRNATAP -0.229390680773225 1.21623659623871e-14 NA NA NA hsa-miR-200b-3p LPIN1 2.11744072703209 1.66710572104191e-43 -1.24151990954073 9.74525630325401e-28 MirTarget;TargetScan -0.155610280257861 3.0608796471282e-10 NA NA NA hsa-miR-200c-3p LPIN1 2.07038651806183 6.84613386286599e-51 -1.24151990954073 9.74525630325401e-28 MirTarget -0.174395403814388 1.36919873659418e-10 NA NA NA hsa-miR-141-3p LPP 2.99777540204168 1.26370498493024e-78 -1.17035459588915 3.47523383485479e-19 TargetScan;miRNATAP -0.171778131081795 2.36177347868105e-11 NA NA NA hsa-miR-200a-3p LPP 2.55218480823434 2.96135446816238e-51 -1.17035459588915 3.47523383485479e-19 miRNATAP -0.160894655353184 1.87353047391844e-10 NA NA NA hsa-miR-143-3p LRBA -1.23248181631499 4.74160976678504e-28 0.322142018050458 0.00274814169043239 miRNATAP -0.169830884683605 8.28799787058905e-08 NA NA NA hsa-miR-28-5p LRBA -0.14267073663385 0.0497619246260571 0.322142018050458 0.00274814169043239 miRanda -0.389047436907926 1.37870639587549e-14 NA NA NA hsa-let-7e-5p LRIG3 0.261471269338985 0.00191077095550257 -1.84053484852599 4.4172645762966e-39 MirTarget -0.284372398018558 2.30107670375748e-06 NA NA NA hsa-miR-200b-3p LRP1 2.11744072703209 1.66710572104191e-43 -1.59623069924697 7.26581692175772e-39 TargetScan -0.390913060990931 5.87625867888281e-53 NA NA NA hsa-miR-28-5p LRP10 -0.14267073663385 0.0497619246260571 -0.0382360620439677 0.56834890677188 miRanda -0.232358089130676 1.36883684380908e-13 NA NA NA hsa-miR-141-3p LRP1B 2.99777540204168 1.26370498493024e-78 -2.7905733237308 1.12458327034934e-14 TargetScan -0.521764006550357 1.2987696393109e-13 NA NA NA hsa-miR-200b-3p LRP1B 2.11744072703209 1.66710572104191e-43 -2.7905733237308 1.12458327034934e-14 MirTarget;TargetScan -0.416901322444173 7.36037135056929e-08 NA NA NA hsa-miR-200c-3p LRP1B 2.07038651806183 6.84613386286599e-51 -2.7905733237308 1.12458327034934e-14 MirTarget;miRNATAP -0.484532815827396 1.23933302299042e-08 NA NA NA hsa-miR-28-5p LRP2 -0.14267073663385 0.0497619246260571 -0.807564034442771 0.0466284114536984 miRanda -0.905474552810496 2.5991405316078e-06 NA NA NA hsa-miR-200b-3p LRP4 2.11744072703209 1.66710572104191e-43 -1.80859309249455 1.72412102466362e-32 MirTarget;TargetScan -0.331471081272014 4.13021317654035e-24 NA NA NA hsa-miR-200c-3p LRP4 2.07038651806183 6.84613386286599e-51 -1.80859309249455 1.72412102466362e-32 MirTarget;miRNATAP -0.350262615415016 2.74986232400513e-22 NA NA NA hsa-miR-28-5p LRRC14 -0.14267073663385 0.0497619246260571 0.640315896061971 1.34396129102918e-16 PITA -0.132665155827186 0.000403097723870531 NA NA NA hsa-miR-28-5p LRRC23 -0.14267073663385 0.0497619246260571 0.541913603183654 5.14487768181524e-09 miRanda -0.226789849549492 3.09023884401323e-07 NA NA NA hsa-miR-28-5p LRRC27 -0.14267073663385 0.0497619246260571 0.371914716525773 3.80448230629096e-06 miRanda -0.19704546268143 2.64263982844557e-07 NA NA NA hsa-miR-28-5p LRRC36 -0.14267073663385 0.0497619246260571 0.665572655767599 8.70102599652953e-05 miRanda -0.198204775980699 0.0145691548364303 NA NA NA hsa-miR-28-5p LRRC37A2 -0.14267073663385 0.0497619246260571 -0.416297658622351 0.00031793945065914 miRanda -0.124952509526358 0.0237623784992372 NA NA NA hsa-miR-141-3p LRRTM2 2.99777540204168 1.26370498493024e-78 -3.13984867257332 7.15618649621249e-76 miRNATAP -0.542374867357902 1.81770437630689e-57 NA NA NA hsa-miR-200a-3p LRRTM2 2.55218480823434 2.96135446816238e-51 -3.13984867257332 7.15618649621249e-76 miRNATAP -0.429652576186034 4.09960647196162e-36 NA NA NA hsa-miR-141-3p LSAMP 2.99777540204168 1.26370498493024e-78 -0.782586811384943 0.000316660451492277 TargetScan -0.317167092175689 3.07332336359974e-14 NA NA NA hsa-miR-141-3p LTBP1 2.99777540204168 1.26370498493024e-78 -0.181835521424575 0.143896069693686 MirTarget -0.14099266757721 4.14111813979571e-09 NA NA NA hsa-miR-200a-3p LTBP1 2.55218480823434 2.96135446816238e-51 -0.181835521424575 0.143896069693686 MirTarget -0.155545472524258 3.39347655502809e-11 NA NA NA hsa-miR-28-5p LY6G6C -0.14267073663385 0.0497619246260571 -0.0705387494557708 0.809641114829419 miRanda -0.561824988628232 5.33804138289076e-05 NA NA NA hsa-miR-28-5p LYPD3 -0.14267073663385 0.0497619246260571 1.45248580283244 1.87328918691671e-19 MirTarget;miRanda;miRNATAP -0.424567607281884 5.19217038033921e-08 NA NA NA hsa-miR-145-5p LYPLA2 -2.62703571936687 7.64402900188551e-88 1.03867651066728 2.15051388059863e-42 miRNAWalker2_validate -0.194085545884774 5.6183448939167e-27 NA NA NA hsa-miR-141-3p MAF 2.99777540204168 1.26370498493024e-78 -1.16207333224511 7.05311108318644e-38 miRNATAP -0.280257139364435 1.13022065741888e-60 NA NA NA hsa-miR-200a-3p MAF 2.55218480823434 2.96135446816238e-51 -1.16207333224511 7.05311108318644e-38 miRNATAP -0.238756255088114 2.38164269278218e-44 NA NA NA hsa-miR-200b-3p MAF 2.11744072703209 1.66710572104191e-43 -1.16207333224511 7.05311108318644e-38 TargetScan -0.269885334079408 6.2084548111735e-46 NA NA NA hsa-miR-200c-3p MAF 2.07038651806183 6.84613386286599e-51 -1.16207333224511 7.05311108318644e-38 miRNATAP -0.318820975446133 8.73388346017541e-54 NA NA NA hsa-miR-28-5p MAGI1 -0.14267073663385 0.0497619246260571 -1.26305301454899 4.04392522280675e-34 miRanda -0.116369081008409 0.0239851302853459 NA NA NA hsa-miR-141-3p MAGI2 2.99777540204168 1.26370498493024e-78 -0.936512824134223 3.7734967109359e-12 TargetScan;miRNATAP -0.151678725006706 8.72379088626456e-09 NA NA NA hsa-miR-200a-3p MAGI2 2.55218480823434 2.96135446816238e-51 -0.936512824134223 3.7734967109359e-12 miRNATAP -0.107014743228385 3.81979744809966e-05 NA NA NA hsa-miR-145-5p MAGOHB -2.62703571936687 7.64402900188551e-88 0.776091825420421 1.34887280216577e-24 MirTarget -0.166654304795558 4.57860496605447e-21 NA NA NA hsa-miR-28-5p MANEAL -0.14267073663385 0.0497619246260571 1.38973021457614 4.18422007286845e-24 miRanda -0.206194475853567 0.00217111584739488 NA NA NA hsa-miR-28-5p MAP1A -0.14267073663385 0.0497619246260571 -0.89250845462883 6.21955962799672e-15 miRanda -0.149629797196379 0.00694585072219689 NA NA NA hsa-miR-141-3p MAP1B 2.99777540204168 1.26370498493024e-78 -1.55002312958356 5.26140421124211e-31 mirMAP -0.332839469538648 4.86786279869509e-38 NA NA NA hsa-miR-200a-3p MAP1B 2.55218480823434 2.96135446816238e-51 -1.55002312958356 5.26140421124211e-31 mirMAP -0.28658158412502 4.962612018885e-29 NA NA NA hsa-miR-200b-3p MAP1B 2.11744072703209 1.66710572104191e-43 -1.55002312958356 5.26140421124211e-31 TargetScan -0.320250401066909 2.60481652801636e-29 NA NA NA hsa-miR-141-3p MAP2 2.99777540204168 1.26370498493024e-78 -1.48495084198261 2.62387512550646e-19 miRNATAP -0.176478146804683 6.58051204564353e-08 NA NA NA hsa-miR-200a-3p MAP2 2.55218480823434 2.96135446816238e-51 -1.48495084198261 2.62387512550646e-19 miRNATAP -0.117147634532134 0.000274750747600608 NA NA NA hsa-miR-200b-3p MAP2 2.11744072703209 1.66710572104191e-43 -1.48495084198261 2.62387512550646e-19 MirTarget;TargetScan -0.128113545004565 0.000348019982381255 NA NA NA hsa-miR-200c-3p MAP2 2.07038651806183 6.84613386286599e-51 -1.48495084198261 2.62387512550646e-19 MirTarget;miRNATAP -0.186944551452252 1.93599375569411e-06 NA NA NA hsa-miR-141-3p MAP3K3 2.99777540204168 1.26370498493024e-78 -0.734541340963792 2.63872799634068e-34 miRNATAP -0.165901727144462 2.60406258844207e-47 NA NA NA hsa-miR-200a-3p MAP3K3 2.55218480823434 2.96135446816238e-51 -0.734541340963792 2.63872799634068e-34 miRNATAP -0.135063200600891 7.18528329824784e-32 NA NA NA hsa-miR-200b-3p MAP3K5 2.11744072703209 1.66710572104191e-43 -1.14088601125645 1.72781404202526e-25 TargetScan -0.203449016952416 4.00360408784291e-18 NA NA NA hsa-miR-141-3p MAP4K4 2.99777540204168 1.26370498493024e-78 -0.308580581654411 0.00014813484298229 TargetScan -0.134453890562392 4.95116248896509e-18 24013097 To understand how miR-141 mediates the phenotype of pancreatic cancer cells a bioinformatics tool was used to identify MAP4K4 as a potential target of miR-141; The Dual-Luciferase reporter gene assay showed that miR-141 binds directly to the 3'-untranslated region 3'UTR of MAP4K4 to inhibit MAP4K4 expression; Western blot and quantitative real-time PCR qRT-PCR analyses revealed that MAP4K4 expression was inversely correlated with miR-141 expression both in pancreatic cancer samples and cell lines; In a nude mouse xenograft model both overexpression of miR-141 and knockdown of MAP4K4 significantly repressed pancreatic cancer cell growth; Therefore we conclude that miR-141 targets MAP4K4 acts as a tumor suppressor in pancreatic cancer cells and may serve as a novel therapeutic agent for miRNA-based pancreatic cancer therapy pancreatic cancer hsa-miR-200b-3p MAP4K4 2.11744072703209 1.66710572104191e-43 -0.308580581654411 0.00014813484298229 TargetScan -0.169304068185926 7.98066390013092e-24 NA NA NA hsa-miR-141-3p MAP7D1 2.99777540204168 1.26370498493024e-78 -0.244894483481591 0.000944722979969239 MirTarget;TargetScan;miRNATAP -0.118140486924444 6.88459313959795e-17 NA NA NA hsa-miR-141-3p MAPRE2 2.99777540204168 1.26370498493024e-78 -0.656745722938772 9.77547037861752e-13 TargetScan -0.126696815442538 1.51157144736313e-12 NA NA NA hsa-miR-132-3p MAPT -0.0365213889238607 0.668598301088667 -0.125705967593898 0.64555550336755 MirTarget -0.442056965841922 6.17526022344575e-05 NA NA NA hsa-miR-28-5p MAPT -0.14267073663385 0.0497619246260571 -0.125705967593898 0.64555550336755 mirMAP -1.05719797085297 1.32790959528459e-16 NA NA NA hsa-miR-200b-3p MARCH8 2.11744072703209 1.66710572104191e-43 -1.14430885937208 3.7997494940241e-16 MirTarget;TargetScan -0.150866268151388 5.89111869995042e-07 NA NA NA hsa-miR-200c-3p MARCH8 2.07038651806183 6.84613386286599e-51 -1.14430885937208 3.7997494940241e-16 MirTarget -0.155368237183204 2.96236320050355e-06 NA NA NA hsa-miR-28-5p MARCH9 -0.14267073663385 0.0497619246260571 0.898335673282321 1.98480673766822e-29 miRanda;miRNATAP -0.209424733313088 8.51235136745986e-08 NA NA NA hsa-miR-141-3p MARK1 2.99777540204168 1.26370498493024e-78 -1.56660457597826 1.63468568431183e-20 TargetScan -0.25176806349255 2.93953065606926e-14 NA NA NA hsa-miR-143-3p MARK2 -1.23248181631499 4.74160976678504e-28 0.66251260638795 8.91612147809151e-27 miRNATAP -0.137907443218408 1.25591095127827e-13 NA NA NA hsa-miR-28-5p MARVELD2 -0.14267073663385 0.0497619246260571 1.12359621955454 1.74234529410055e-20 miRanda -0.411412447084188 1.81375532045569e-12 NA NA NA hsa-miR-28-5p MAT2A -0.14267073663385 0.0497619246260571 0.106201174005506 0.0211943042401361 PITA;miRanda;miRNATAP -0.117893335118824 5.76635278592976e-08 NA NA NA hsa-miR-28-5p MAX -0.14267073663385 0.0497619246260571 0.189520873245771 3.41527676404311e-05 miRanda -0.126434947821145 4.87379608519139e-09 NA NA NA hsa-miR-28-5p MAZ -0.14267073663385 0.0497619246260571 1.53688020659836 2.44860030148443e-84 miRanda -0.16614489256984 6.82417495538852e-05 NA NA NA hsa-miR-141-3p MBNL1 2.99777540204168 1.26370498493024e-78 -1.03065753199503 1.22543346240534e-51 MirTarget;TargetScan;miRNATAP -0.175269017211848 1.09514095748495e-38 NA NA NA hsa-miR-200a-3p MBNL1 2.55218480823434 2.96135446816238e-51 -1.03065753199503 1.22543346240534e-51 MirTarget;miRNATAP -0.153315498753731 1.78628757092243e-30 NA NA NA hsa-miR-200b-3p MBNL1 2.11744072703209 1.66710572104191e-43 -1.03065753199503 1.22543346240534e-51 TargetScan -0.17491088267422 4.16579198660803e-32 NA NA NA hsa-miR-200c-3p MBNL1 2.07038651806183 6.84613386286599e-51 -1.03065753199503 1.22543346240534e-51 miRNATAP -0.204901368872066 1.2774301807245e-36 NA NA NA hsa-miR-200c-3p MBNL2 2.07038651806183 6.84613386286599e-51 -1.37379574443944 8.08248700954969e-39 miRNATAP -0.222396480040019 1.38680969745804e-18 NA NA NA hsa-miR-141-3p MBNL3 2.99777540204168 1.26370498493024e-78 -1.92990157111799 7.13881373145437e-25 MirTarget;TargetScan;miRNATAP -0.327014549420147 5.90250368501858e-19 NA NA NA hsa-miR-200a-3p MBNL3 2.55218480823434 2.96135446816238e-51 -1.92990157111799 7.13881373145437e-25 MirTarget;miRNATAP -0.294548796335619 4.13743425781522e-16 NA NA NA hsa-miR-200b-3p MBNL3 2.11744072703209 1.66710572104191e-43 -1.92990157111799 7.13881373145437e-25 MirTarget;TargetScan -0.319731542353063 2.16635878136419e-15 NA NA NA hsa-miR-200c-3p MBNL3 2.07038651806183 6.84613386286599e-51 -1.92990157111799 7.13881373145437e-25 MirTarget;mirMAP -0.347391597010734 4.75813168464757e-15 NA NA NA hsa-let-7e-5p MBP 0.261471269338985 0.00191077095550257 -1.05743986242831 1.70792931878289e-20 mirMAP -0.14482735995552 0.00240921468282261 NA NA NA hsa-miR-141-3p MBP 2.99777540204168 1.26370498493024e-78 -1.05743986242831 1.70792931878289e-20 mirMAP -0.125591567342395 2.50155581738413e-08 NA NA NA hsa-miR-200b-3p MCC 2.11744072703209 1.66710572104191e-43 -1.14440901729692 6.9012862547581e-21 TargetScan -0.177840933340175 1.22599606768502e-11 NA NA NA hsa-miR-200b-3p MCFD2 2.11744072703209 1.66710572104191e-43 -0.543306041289844 1.28010442553734e-20 MirTarget;TargetScan -0.109470392395964 1.0353815636115e-18 NA NA NA hsa-miR-200c-3p MCFD2 2.07038651806183 6.84613386286599e-51 -0.543306041289844 1.28010442553734e-20 MirTarget -0.103018000699861 5.90812546517832e-14 NA NA NA hsa-miR-141-3p MCOLN3 2.99777540204168 1.26370498493024e-78 -1.28921105052088 2.09632759584398e-11 MirTarget;TargetScan -0.163664882541194 1.45877992335885e-05 NA NA NA hsa-miR-200a-3p MCOLN3 2.55218480823434 2.96135446816238e-51 -1.28921105052088 2.09632759584398e-11 MirTarget -0.201531738530857 4.80797859507484e-08 NA NA NA hsa-miR-141-3p MDGA1 2.99777540204168 1.26370498493024e-78 -0.0639263710072093 0.639909371226836 TargetScan;miRNATAP -0.193416619747444 1.47399458931137e-13 NA NA NA hsa-miR-200a-3p MDGA1 2.55218480823434 2.96135446816238e-51 -0.0639263710072093 0.639909371226836 miRNATAP -0.144693783337777 2.19166116828042e-08 NA NA NA hsa-miR-28-5p MDGA1 -0.14267073663385 0.0497619246260571 -0.0639263710072093 0.639909371226836 miRNATAP -0.263808512948126 4.75417121782066e-05 NA NA NA hsa-miR-143-3p MDM2 -1.23248181631499 4.74160976678504e-28 0.134052426741699 0.110706751806459 miRNAWalker2_validate -0.116551192492011 2.45785814867103e-06 NA NA NA hsa-miR-28-5p MED24 -0.14267073663385 0.0497619246260571 0.522193665864754 1.4256037186934e-07 miRanda -0.136336954991214 0.00416518893178145 NA NA NA hsa-miR-28-5p MED29 -0.14267073663385 0.0497619246260571 0.407823011340064 6.51199119798712e-14 miRanda -0.166233170354608 1.57916262167401e-10 NA NA NA hsa-miR-28-5p MEGF9 -0.14267073663385 0.0497619246260571 -0.296058092250146 0.0106105936693003 miRanda -0.275598713069223 5.27830665815295e-07 NA NA NA hsa-let-7e-5p MEIS2 0.261471269338985 0.00191077095550257 -1.95002058092382 8.956929391428e-51 miRNATAP -0.171612469367425 0.00247718450378295 NA NA NA hsa-miR-141-3p MEIS2 2.99777540204168 1.26370498493024e-78 -1.95002058092382 8.956929391428e-51 TargetScan -0.363924271571133 2.56704000410149e-46 NA NA NA hsa-miR-28-5p MESDC1 -0.14267073663385 0.0497619246260571 0.579182445134239 2.26276233786632e-17 miRanda -0.100322410657288 0.00245928979734788 NA NA NA hsa-miR-28-5p METRN -0.14267073663385 0.0497619246260571 2.74122843395692 8.22387646584694e-39 mirMAP -0.871114346109805 3.27959210094149e-17 NA NA NA hsa-miR-200a-3p MFAP3L 2.55218480823434 2.96135446816238e-51 -0.596269094340481 7.72914739798849e-05 MirTarget -0.116652654374201 5.12290232089732e-05 NA NA NA hsa-miR-200b-3p MFAP5 2.11744072703209 1.66710572104191e-43 -1.7372996699481 1.15820603382006e-18 TargetScan -0.416640331285456 1.23444205417206e-23 NA NA NA hsa-miR-200c-3p MFAP5 2.07038651806183 6.84613386286599e-51 -1.7372996699481 1.15820603382006e-18 miRNATAP -0.504700300707793 1.08619258765981e-28 NA NA NA hsa-miR-200b-3p MFHAS1 2.11744072703209 1.66710572104191e-43 -0.23084721682902 0.0617583813746145 TargetScan -0.115117033872735 1.04754818783411e-05 NA NA NA hsa-miR-200c-3p MGAT3 2.07038651806183 6.84613386286599e-51 -1.9246123472567 1.2847337143263e-31 miRNATAP -0.352188306418152 1.89315166994181e-19 NA NA NA hsa-miR-145-5p MGAT4A -2.62703571936687 7.64402900188551e-88 0.493804333900288 3.29725111038758e-05 mirMAP -0.109434679951773 7.6673486251121e-05 NA NA NA hsa-miR-141-3p MGAT5 2.99777540204168 1.26370498493024e-78 -0.845793008139424 7.3367191920958e-06 TargetScan;mirMAP -0.159081686829536 1.49245463471532e-05 NA NA NA hsa-miR-200a-3p MGAT5 2.55218480823434 2.96135446816238e-51 -0.845793008139424 7.3367191920958e-06 mirMAP -0.16067184550895 8.24099718241873e-06 NA NA NA hsa-miR-132-3p MIA3 -0.0365213889238607 0.668598301088667 0.221548080039061 0.00564822970581639 MirTarget;miRNATAP -0.216828764409507 1.3551484728515e-11 NA NA NA hsa-miR-141-3p MICAL3 2.99777540204168 1.26370498493024e-78 -0.95590506366019 6.06115901437355e-27 mirMAP -0.110292938795541 4.51096898205879e-10 NA NA NA hsa-miR-200a-3p MICAL3 2.55218480823434 2.96135446816238e-51 -0.95590506366019 6.06115901437355e-27 mirMAP -0.106757529539423 7.76119124383125e-10 NA NA NA hsa-miR-28-5p MID2 -0.14267073663385 0.0497619246260571 -0.799925928617615 7.05192180338706e-20 miRanda -0.132368175980547 0.00192648108990026 NA NA NA hsa-miR-200c-3p MITF 2.07038651806183 6.84613386286599e-51 -1.35051354106808 1.10754633569261e-32 miRNATAP -0.382284463696344 3.10046832412687e-49 NA NA NA hsa-miR-200b-3p MMD 2.11744072703209 1.66710572104191e-43 -2.29894276851442 1.03228947173554e-69 TargetScan -0.462073269053207 2.32292736704446e-61 NA NA NA hsa-miR-200c-3p MMD 2.07038651806183 6.84613386286599e-51 -2.29894276851442 1.03228947173554e-69 miRNATAP -0.503467849869215 4.38383159952573e-60 NA NA NA hsa-miR-200b-3p MMGT1 2.11744072703209 1.66710572104191e-43 -0.617659717682437 3.70461431852723e-20 MirTarget -0.10615928976706 1.47047707755359e-13 NA NA NA hsa-miR-145-5p MMP1 -2.62703571936687 7.64402900188551e-88 6.06794406171332 1.97080965138208e-60 miRNAWalker2_validate -0.776560200165228 1.4991690670364e-17 NA NA NA hsa-miR-28-5p MMP11 -0.14267073663385 0.0497619246260571 6.04945497433362 1.03023931867355e-137 miRanda -0.429299903434847 0.00172361360383875 NA NA NA hsa-miR-145-5p MMP12 -2.62703571936687 7.64402900188551e-88 1.47938135981664 1.47098262596235e-05 miRNAWalker2_validate -0.192036777823138 0.0160531504579215 NA NA NA hsa-miR-143-3p MMP13 -1.23248181631499 4.74160976678504e-28 6.71640412670262 7.74215774273361e-81 miRNAWalker2_validate -0.508349675625 1.03503351857542e-05 21427707;24762226;23732700 Western blot analyses revealed that MMP-13 was mostly protein downregulated by miR-143;Moreover the overexpression of miR-143 decreased MMP-13 protein level; Finally the neutralization of miR-143 by anti-miR-143 antibody reversed the effect of propofol on cell proliferation apoptosis and invasion and upregulated MMP-13 expression in MG63 cells; Taken together propofol may have antitumor potential in osteosarcoma which is partly due to the downregulation of MMP-13 expression by miR-143;MicroRNA 143 inhibits cell migration and invasion by targeting matrix metalloproteinase 13 in prostate cancer; In addition to the best of our knowledge miR-143 was reported for the first time to directly target matrix metalloproteinase 13 MMP-13 in prostate cancer; The results of the present study demonstrated that miR-143 suppresses cell migration and invasion by targeting MMP-13 in prostate cancer cell lines ;;cell migration sarcoma;sarcoma;prostate cancer hsa-miR-145-5p MMP14 -2.62703571936687 7.64402900188551e-88 1.17709675366481 4.88698053995378e-22 miRNAWalker2_validate -0.100472607295886 0.00054272881478419 NA NA NA hsa-miR-141-3p MMP16 2.99777540204168 1.26370498493024e-78 -0.481934192325192 0.0113040399956389 TargetScan -0.293734231626602 7.14719307279982e-16 NA NA NA hsa-miR-200b-3p MMP16 2.11744072703209 1.66710572104191e-43 -0.481934192325192 0.0113040399956389 TargetScan -0.271198441852451 1.13277150858291e-11 NA NA NA hsa-miR-141-3p MN1 2.99777540204168 1.26370498493024e-78 -0.459509646859896 0.00118312104981719 TargetScan -0.304352355434743 3.01070746708641e-30 NA NA NA hsa-miR-200b-3p MOCS1 2.11744072703209 1.66710572104191e-43 -1.97216951564682 5.39670718242351e-81 TargetScan -0.309009734903682 1.06314108116799e-40 NA NA NA hsa-miR-143-3p MOGS -1.23248181631499 4.74160976678504e-28 0.841777372485515 5.58366171399404e-40 MirTarget -0.157391252784521 5.22538000069471e-16 NA NA NA hsa-miR-132-3p MON2 -0.0365213889238607 0.668598301088667 -0.531742758397095 8.92863225323636e-16 mirMAP -0.116287927175114 1.81938272398056e-05 NA NA NA hsa-miR-28-5p MORF4L2 -0.14267073663385 0.0497619246260571 0.754044361942787 2.09810836739711e-29 MirTarget;miRanda;miRNATAP -0.148347261398627 6.48658571412929e-06 NA NA NA hsa-miR-28-5p MOV10L1 -0.14267073663385 0.0497619246260571 -0.297466473208126 0.0920646073093874 miRanda -0.200559727756046 0.017178490274872 NA NA NA hsa-miR-200b-3p MPDZ 2.11744072703209 1.66710572104191e-43 -1.4560885223525 1.43773083617831e-46 MirTarget -0.226725321198426 1.79436119144364e-24 NA NA NA hsa-miR-200c-3p MPDZ 2.07038651806183 6.84613386286599e-51 -1.4560885223525 1.43773083617831e-46 MirTarget -0.253733095771084 2.41521592177249e-25 NA NA NA hsa-miR-28-5p MPI -0.14267073663385 0.0497619246260571 0.028970874839473 0.6353259007928 miRanda -0.168930693478824 4.35470728606857e-09 NA NA NA hsa-let-7e-5p MPL 0.261471269338985 0.00191077095550257 -1.55729613911731 1.15011006095171e-60 miRNAWalker2_validate -0.108150095010754 0.009759901565627 NA NA NA hsa-miR-141-3p MPPED2 2.99777540204168 1.26370498493024e-78 -1.92995077631031 1.27147853851054e-23 TargetScan -0.294365915993185 8.68483398384101e-15 NA NA NA hsa-miR-141-3p MPRIP 2.99777540204168 1.26370498493024e-78 -0.644300216328719 4.0274408922109e-28 TargetScan -0.161832374420818 2.64483974336262e-48 NA NA NA hsa-miR-200b-3p MPRIP 2.11744072703209 1.66710572104191e-43 -0.644300216328719 4.0274408922109e-28 MirTarget;TargetScan -0.133799171371761 5.2915762214808e-27 NA NA NA hsa-miR-200c-3p MPRIP 2.07038651806183 6.84613386286599e-51 -0.644300216328719 4.0274408922109e-28 MirTarget;miRNATAP -0.187194770996915 1.34654418726286e-44 NA NA NA hsa-miR-28-5p MR1 -0.14267073663385 0.0497619246260571 0.327436070496887 0.000151124551464722 miRanda -0.11465704514548 0.00545481477812533 NA NA NA hsa-let-7e-5p MRAS 0.261471269338985 0.00191077095550257 -2.33160876190743 5.5050134478505e-74 mirMAP -0.192389755360429 0.000819872247169388 NA NA NA hsa-miR-28-5p MRPL17 -0.14267073663385 0.0497619246260571 1.00679596033877 1.95241823571098e-45 miRanda -0.107583871355843 0.00267303465044058 NA NA NA hsa-miR-28-5p MRPS35 -0.14267073663385 0.0497619246260571 0.546529477360202 2.2953747137935e-18 miRanda -0.11368310884075 0.000176002275848875 NA NA NA hsa-miR-200b-3p MRVI1 2.11744072703209 1.66710572104191e-43 -1.28848982300958 1.34334434965756e-30 MirTarget -0.292914570668046 3.09474793701166e-35 NA NA NA hsa-miR-200c-3p MRVI1 2.07038651806183 6.84613386286599e-51 -1.28848982300958 1.34334434965756e-30 MirTarget -0.34784748675264 1.89463452245531e-41 NA NA NA hsa-miR-28-5p MS4A2 -0.14267073663385 0.0497619246260571 -0.791944427086409 0.00109280176197654 miRanda -1.00321375313711 9.28749255223754e-19 NA NA NA hsa-miR-200b-3p MSN 2.11744072703209 1.66710572104191e-43 -0.578039968356322 4.29885633617379e-10 MirTarget;TargetScan -0.168931968633106 3.68772184314926e-18 24037528 MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways; Instead we found that miR-200b repressed several actin-associated genes with the knockdown of the ezrin-radixin-moesin family member moesin alone phenocopying the repression of cell invasion by miR-200b; Moesin was verified to be directly targeted by miR-200b and restoration of moesin in miR-200b-expressing cells was sufficient to alleviate metastatic repression; In breast cancer cell lines and patient samples the expression of moesin significantly inversely correlated with miR-200 expression and high levels of moesin were associated with poor relapse-free survival metastasis;poor survival breast cancer hsa-miR-200c-3p MSN 2.07038651806183 6.84613386286599e-51 -0.578039968356322 4.29885633617379e-10 miRNAWalker2_validate;miRTarBase;MirTarget -0.193434786532672 1.25331591841618e-19 NA NA NA hsa-miR-200b-3p MSRB3 2.11744072703209 1.66710572104191e-43 -2.04546871502378 2.21436286434622e-54 mirMAP -0.41551256735815 2.79065379396152e-49 NA NA NA hsa-miR-200c-3p MSRB3 2.07038651806183 6.84613386286599e-51 -2.04546871502378 2.21436286434622e-54 mirMAP -0.514534020899057 2.09845636418037e-64 NA NA NA hsa-miR-200c-3p MTUS1 2.07038651806183 6.84613386286599e-51 -0.903333305111318 7.6977763693091e-17 miRNATAP -0.152390042094713 2.46939519817383e-09 NA NA NA hsa-miR-145-5p MUC1 -2.62703571936687 7.64402900188551e-88 2.6031293995538 1.72038877386261e-27 miRNAWalker2_validate;miRTarBase -0.381041291185968 2.23197939904781e-11 24157791 MiR 145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1; MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3'UTRs; Importantly the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145 respectively; Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1 functioning as a tumor suppressor ovarian cancer hsa-miR-28-5p MUC2 -0.14267073663385 0.0497619246260571 2.26355229838227 1.52647808582801e-07 miRanda -1.17344429096599 1.12063804571833e-08 NA NA NA hsa-miR-28-5p MUM1 -0.14267073663385 0.0497619246260571 -0.126556156553718 0.0782751092469258 miRanda -0.129631276755681 0.000144830852269932 NA NA NA hsa-miR-28-5p MUM1L1 -0.14267073663385 0.0497619246260571 -0.158739344936463 0.536343388622944 miRanda -0.704525822706198 6.29784602575918e-09 NA NA NA hsa-miR-200b-3p MXI1 2.11744072703209 1.66710572104191e-43 -1.09569304324504 4.15005057850764e-34 TargetScan -0.108579957214413 3.94030003344781e-08 NA NA NA hsa-miR-28-5p MYB -0.14267073663385 0.0497619246260571 1.3385004671291 4.8746375657764e-10 miRanda -0.793948725008808 6.86876365185527e-15 NA NA NA hsa-miR-28-5p MYCBPAP -0.14267073663385 0.0497619246260571 0.270395883018356 0.168169145671457 miRanda -0.521583955632841 1.89815971070376e-08 NA NA NA hsa-miR-28-5p MYEF2 -0.14267073663385 0.0497619246260571 0.553427331133231 2.34778821065553e-05 miRanda -0.154420149585165 0.0136797924479402 NA NA NA hsa-miR-141-3p MYH10 2.99777540204168 1.26370498493024e-78 -0.758370724363282 8.91647543769729e-19 TargetScan;miRNATAP -0.168957276481543 1.73018252591467e-24 NA NA NA hsa-miR-200a-3p MYH10 2.55218480823434 2.96135446816238e-51 -0.758370724363282 8.91647543769729e-19 miRNATAP -0.148172420907332 1.17786148310824e-19 NA NA NA hsa-miR-28-5p MYLIP -0.14267073663385 0.0497619246260571 -0.57505884257391 2.93951647319766e-11 miRanda -0.271745980842622 4.32764111087329e-11 NA NA NA hsa-miR-200b-3p MYLK 2.11744072703209 1.66710572104191e-43 -2.468210552686 9.30073457733719e-63 TargetScan -0.309913441680872 8.09237031263242e-21 NA NA NA hsa-let-7e-5p MYO1F 0.261471269338985 0.00191077095550257 0.494803519138374 9.45427413842688e-06 miRNATAP -0.108163639329196 0.0185310055065272 NA NA NA hsa-miR-141-3p MYO5A 2.99777540204168 1.26370498493024e-78 -0.398919677130254 2.00854123129672e-06 TargetScan -0.102524688816236 2.73472289781491e-10 NA NA NA hsa-miR-200b-3p MYO5A 2.11744072703209 1.66710572104191e-43 -0.398919677130254 2.00854123129672e-06 mirMAP -0.10348783881442 5.55036219904604e-09 NA NA NA hsa-miR-200c-3p MYO5A 2.07038651806183 6.84613386286599e-51 -0.398919677130254 2.00854123129672e-06 mirMAP -0.117857746896427 1.52096258652778e-09 NA NA NA hsa-miR-28-5p MYO5C -0.14267073663385 0.0497619246260571 -0.148719986034905 0.196143460079208 miRanda -0.387154085850764 8.02386753686477e-13 NA NA NA hsa-miR-143-3p MYO6 -1.23248181631499 4.74160976678504e-28 0.64462966298129 1.058698364996e-10 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.185502933006214 3.59686893777106e-10 20353999 A computational search indicated the 3'-untranslated region UTR of the mRNA for myosin VI MYO6 as a potential target for both miR-143 and miR-145 the expression of which was reduced in the tumor tissues; In luciferase reporter analysis we find a significant negative regulatory effect on the MYO6 3'UTR by both miR-143 and miR-145; Mutation of the potential binding sites for miR-143 and miR-145 in the MYO6 3'UTR resulted in a loss of responsiveness to the corresponding miRNA; Our data indicate that miR-143 and miR-145 are involved in the regulation of MYO6 expression and possibly in the development of prostate cancer prostate cancer hsa-miR-145-5p MYO6 -2.62703571936687 7.64402900188551e-88 0.64462966298129 1.058698364996e-10 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.116693579773699 5.6139791172851e-07 20353999 A computational search indicated the 3'-untranslated region UTR of the mRNA for myosin VI MYO6 as a potential target for both miR-143 and miR-145 the expression of which was reduced in the tumor tissues; In luciferase reporter analysis we find a significant negative regulatory effect on the MYO6 3'UTR by both miR-143 and miR-145; Mutation of the potential binding sites for miR-143 and miR-145 in the MYO6 3'UTR resulted in a loss of responsiveness to the corresponding miRNA; Our data indicate that miR-143 and miR-145 are involved in the regulation of MYO6 expression and possibly in the development of prostate cancer prostate cancer hsa-miR-141-3p MYO9A 2.99777540204168 1.26370498493024e-78 -1.40955646491574 1.09089456601387e-22 TargetScan -0.232727140523994 1.61261894664566e-16 NA NA NA hsa-miR-200b-3p MYO9A 2.11744072703209 1.66710572104191e-43 -1.40955646491574 1.09089456601387e-22 TargetScan -0.204673996961689 4.11267655935714e-11 NA NA NA hsa-miR-28-5p MYOZ3 -0.14267073663385 0.0497619246260571 -0.711322284940144 0.000149018891882461 miRanda -0.341141244970893 0.000137356928333869 NA NA NA hsa-miR-200b-3p MYPN 2.11744072703209 1.66710572104191e-43 -0.379441699415515 0.177285983027929 TargetScan -0.240031659737225 5.48868276948628e-05 NA NA NA hsa-miR-141-3p MYRIP 2.99777540204168 1.26370498493024e-78 -2.17370145905386 1.8691130119275e-20 MirTarget;TargetScan -0.447914278860007 7.45923333091757e-23 NA NA NA hsa-miR-200a-3p MYRIP 2.55218480823434 2.96135446816238e-51 -2.17370145905386 1.8691130119275e-20 MirTarget -0.332385253579732 1.96060370821431e-13 NA NA NA hsa-miR-28-5p MYT1 -0.14267073663385 0.0497619246260571 3.12383178963035 2.84482084584268e-20 miRanda -0.858419706373622 1.75550265549345e-07 NA NA NA hsa-miR-200b-3p N4BP2 2.11744072703209 1.66710572104191e-43 -0.756054494854111 3.74801492146601e-06 TargetScan -0.127770906231228 0.000241836548169462 NA NA NA hsa-miR-200b-3p NAB1 2.11744072703209 1.66710572104191e-43 -1.06240474610946 1.78235336600763e-35 MirTarget;TargetScan -0.1283812049395 6.82435465444992e-12 NA NA NA hsa-miR-200c-3p NAB1 2.07038651806183 6.84613386286599e-51 -1.06240474610946 1.78235336600763e-35 MirTarget;miRNATAP -0.160505669558308 4.74227689000818e-15 NA NA NA hsa-miR-28-5p NAGPA -0.14267073663385 0.0497619246260571 0.476491606622916 3.65876806231442e-10 miRanda -0.100081318214584 0.00618236613995102 NA NA NA hsa-miR-200b-3p NALCN 2.11744072703209 1.66710572104191e-43 -1.41930195137925 1.65240218006176e-12 MirTarget -0.154340387081952 0.000350214007141606 NA NA NA hsa-miR-200c-3p NALCN 2.07038651806183 6.84613386286599e-51 -1.41930195137925 1.65240218006176e-12 MirTarget -0.19472505977526 4.01388029363856e-05 NA NA NA hsa-miR-200b-3p NAP1L5 2.11744072703209 1.66710572104191e-43 -1.09993598867014 5.12983053371275e-25 MirTarget -0.10270428763052 9.46391566799738e-06 NA NA NA hsa-miR-200c-3p NAP1L5 2.07038651806183 6.84613386286599e-51 -1.09993598867014 5.12983053371275e-25 MirTarget;miRNATAP -0.176603895915331 2.83800688791621e-12 NA NA NA hsa-miR-28-5p NAV1 -0.14267073663385 0.0497619246260571 -0.159057359476455 0.12674105203339 MirTarget;miRanda -0.148433487492913 0.00274439035375534 NA NA NA hsa-miR-141-3p NAV3 2.99777540204168 1.26370498493024e-78 -1.78347027501907 7.45924181306669e-19 mirMAP -0.375856079138767 5.47467915471397e-22 NA NA NA hsa-miR-200a-3p NAV3 2.55218480823434 2.96135446816238e-51 -1.78347027501907 7.45924181306669e-19 mirMAP -0.286122528392311 1.40165004590312e-13 NA NA NA hsa-miR-141-3p NBPF14 2.99777540204168 1.26370498493024e-78 -0.767813346588161 6.20641831716256e-09 MirTarget -0.101885875248119 8.12590685240456e-05 NA NA NA hsa-miR-141-3p NCAM1 2.99777540204168 1.26370498493024e-78 -2.68069543446954 3.3168998510845e-39 TargetScan -0.495415877580315 3.84258736225889e-35 NA NA NA hsa-miR-200b-3p NCAM1 2.11744072703209 1.66710572104191e-43 -2.68069543446954 3.3168998510845e-39 TargetScan -0.425947803119043 1.0214634018228e-21 NA NA NA hsa-miR-200c-3p NCAM1 2.07038651806183 6.84613386286599e-51 -2.68069543446954 3.3168998510845e-39 miRTarBase -0.537372709763967 1.49098248094642e-28 NA NA NA hsa-miR-132-3p NCKAP5 -0.0365213889238607 0.668598301088667 -0.338000602603042 0.0132701464171228 MirTarget -0.171509067100474 0.00192034509005472 NA NA NA hsa-miR-200b-3p NCOA2 2.11744072703209 1.66710572104191e-43 -0.732997156847359 7.11379790206388e-05 TargetScan -0.104807825032694 0.00765794540747811 NA NA NA hsa-miR-200b-3p NCOA7 2.11744072703209 1.66710572104191e-43 -1.46179265416623 4.61172460603693e-28 TargetScan -0.163489132778339 1.74079841724172e-08 NA NA NA hsa-miR-200c-3p NCOA7 2.07038651806183 6.84613386286599e-51 -1.46179265416623 4.61172460603693e-28 miRNATAP -0.180152899527411 1.62437726153357e-08 NA NA NA hsa-miR-28-5p NDE1 -0.14267073663385 0.0497619246260571 0.875339226885404 7.92857237232874e-36 PITA;miRanda -0.103552782556862 0.00294271629492361 NA NA NA hsa-miR-200b-3p NDN 2.11744072703209 1.66710572104191e-43 -1.89746127679983 3.59681018967678e-48 MirTarget;TargetScan -0.418648124026625 2.06991099599249e-52 NA NA NA hsa-miR-200c-3p NDN 2.07038651806183 6.84613386286599e-51 -1.89746127679983 3.59681018967678e-48 MirTarget;miRNATAP -0.537443968241421 7.51347077558241e-75 NA NA NA hsa-miR-200c-3p NDST1 2.07038651806183 6.84613386286599e-51 -0.622870054013256 1.51055434858535e-18 miRNATAP -0.108411045470356 8.44309547512392e-11 NA NA NA hsa-miR-28-5p NDUFS4 -0.14267073663385 0.0497619246260571 -0.301526713163377 1.63649105931826e-06 miRanda -0.15098636267489 4.48455928241219e-07 NA NA NA hsa-miR-141-3p NECAB1 2.99777540204168 1.26370498493024e-78 -2.63199442138026 1.09732956901876e-54 MirTarget;TargetScan -0.464169765644387 5.07128486837852e-44 NA NA NA hsa-miR-200a-3p NECAB1 2.55218480823434 2.96135446816238e-51 -2.63199442138026 1.09732956901876e-54 MirTarget -0.361970094879838 2.74901481318086e-27 NA NA NA hsa-miR-143-3p NECAP1 -1.23248181631499 4.74160976678504e-28 0.194681737356563 0.00227095720937965 MirTarget;miRNATAP -0.122948247784029 4.57914183956745e-11 NA NA NA hsa-miR-28-5p NECAP1 -0.14267073663385 0.0497619246260571 0.194681737356563 0.00227095720937965 miRanda -0.157152843023967 1.95426624970528e-07 NA NA NA hsa-miR-200b-3p NEGR1 2.11744072703209 1.66710572104191e-43 -1.47578312334775 1.91555519072321e-16 TargetScan -0.38245958542877 3.67572271094342e-24 NA NA NA hsa-miR-200c-3p NEGR1 2.07038651806183 6.84613386286599e-51 -1.47578312334775 1.91555519072321e-16 miRNATAP -0.493083717095714 2.37755484081141e-33 NA NA NA hsa-miR-28-5p NEIL2 -0.14267073663385 0.0497619246260571 -0.0448079050208445 0.544773057514391 miRanda -0.119176975433056 0.000691336086998745 NA NA NA hsa-miR-28-5p NEK11 -0.14267073663385 0.0497619246260571 0.128069407523834 0.188727293195575 miRanda -0.207811713330311 6.84039361090454e-06 NA NA NA hsa-miR-143-3p NEK5 -1.23248181631499 4.74160976678504e-28 0.98883504276549 3.10194890502704e-05 MirTarget -0.200300082602623 0.00452744087181553 NA NA NA hsa-miR-200c-3p NEK9 2.07038651806183 6.84613386286599e-51 -0.60343465464345 2.91093269226533e-23 MirTarget -0.131744594294364 1.79323167788526e-20 NA NA NA hsa-miR-28-5p NEK9 -0.14267073663385 0.0497619246260571 -0.60343465464345 2.91093269226533e-23 miRanda -0.211923929411196 4.69742347617414e-13 NA NA NA hsa-miR-28-5p NELL1 -0.14267073663385 0.0497619246260571 0.559671843191762 0.100112035151243 miRanda -0.443668109807395 0.00622745471416146 NA NA NA hsa-miR-28-5p NF1 -0.14267073663385 0.0497619246260571 -0.394546709839459 1.88157518863882e-05 miRanda -0.10961770733041 0.0129522477508265 NA NA NA hsa-miR-141-3p NFASC 2.99777540204168 1.26370498493024e-78 -1.57641481096258 2.66191878939881e-16 MirTarget;TargetScan;miRNATAP -0.10233741868113 0.0073061405796248 NA NA NA hsa-miR-141-3p NFAT5 2.99777540204168 1.26370498493024e-78 -1.19902512228777 7.36927955059717e-50 mirMAP -0.149337877858226 6.05474618072504e-20 NA NA NA hsa-miR-200a-3p NFAT5 2.55218480823434 2.96135446816238e-51 -1.19902512228777 7.36927955059717e-50 mirMAP -0.120533278835972 8.59748977733914e-14 NA NA NA hsa-miR-141-3p NFIA 2.99777540204168 1.26370498493024e-78 -0.857176611747856 7.06120416014585e-11 TargetScan;miRNATAP -0.149896213771147 5.12177143293541e-09 NA NA NA hsa-miR-200a-3p NFIA 2.55218480823434 2.96135446816238e-51 -0.857176611747856 7.06120416014585e-11 miRNATAP -0.124471139488281 8.16997121235824e-07 NA NA NA hsa-miR-200b-3p NFIA 2.11744072703209 1.66710572104191e-43 -0.857176611747856 7.06120416014585e-11 MirTarget;TargetScan -0.136370657781913 1.19468664626153e-06 NA NA NA hsa-miR-200c-3p NFIA 2.07038651806183 6.84613386286599e-51 -0.857176611747856 7.06120416014585e-11 MirTarget;miRNATAP -0.189698437288321 6.84090134970592e-10 NA NA NA hsa-miR-200a-3p NFIB 2.55218480823434 2.96135446816238e-51 -2.2930778520164 2.43578303149819e-46 mirMAP -0.234033880119789 2.6081515959604e-13 NA NA NA hsa-miR-200b-3p NFIB 2.11744072703209 1.66710572104191e-43 -2.2930778520164 2.43578303149819e-46 TargetScan -0.233757571008219 5.86506542792963e-11 NA NA NA hsa-miR-200c-3p NFIB 2.07038651806183 6.84613386286599e-51 -2.2930778520164 2.43578303149819e-46 miRNATAP -0.24001569104298 1.03974921818409e-09 NA NA NA hsa-miR-28-5p NFIC -0.14267073663385 0.0497619246260571 -0.323552442007893 0.00148597690443502 mirMAP -0.207358253445271 1.85345111409416e-05 NA NA NA hsa-miR-141-3p NIPAL2 2.99777540204168 1.26370498493024e-78 -0.846763626730118 4.81508775457977e-08 mirMAP -0.139176829235694 4.2925807542727e-06 NA NA NA hsa-miR-200a-3p NIPAL2 2.55218480823434 2.96135446816238e-51 -0.846763626730118 4.81508775457977e-08 mirMAP -0.167407733851061 1.57095367414392e-08 NA NA NA hsa-miR-145-5p NIPSNAP1 -2.62703571936687 7.64402900188551e-88 1.15064562678506 4.6913047115871e-55 miRNAWalker2_validate -0.229313090452633 2.0106869959855e-39 NA NA NA hsa-miR-28-5p NKAIN1 -0.14267073663385 0.0497619246260571 3.58782119473036 3.15479732457313e-27 miRanda -1.02962002614055 2.05084781347217e-10 NA NA NA hsa-miR-200b-3p NLGN1 2.11744072703209 1.66710572104191e-43 -3.7835062742775 6.74291502414997e-47 mirMAP -0.531738282008383 4.1284353210261e-20 NA NA NA hsa-miR-200b-3p NLGN4X 2.11744072703209 1.66710572104191e-43 -2.18618561323443 1.18944185794112e-21 TargetScan -0.32772964277698 2.87973503213682e-11 NA NA NA hsa-miR-200c-3p NLGN4X 2.07038651806183 6.84613386286599e-51 -2.18618561323443 1.18944185794112e-21 miRNATAP -0.428719634813815 1.74343119230385e-15 NA NA NA hsa-miR-132-3p NLK -0.0365213889238607 0.668598301088667 0.568183653225175 4.68554951142873e-14 miRNATAP -0.147434106687348 1.72134800695252e-06 NA NA NA hsa-miR-28-5p NLK -0.14267073663385 0.0497619246260571 0.568183653225175 4.68554951142873e-14 miRanda -0.182841180159811 4.4803820168759e-07 NA NA NA hsa-miR-141-3p NMNAT2 2.99777540204168 1.26370498493024e-78 -3.00997488398387 7.40983336735889e-47 miRNATAP -0.459097254377581 4.326625246712e-28 NA NA NA hsa-miR-200a-3p NMNAT2 2.55218480823434 2.96135446816238e-51 -3.00997488398387 7.40983336735889e-47 miRNATAP -0.382254263797924 2.70376384151858e-20 NA NA NA hsa-miR-200b-3p NOG 2.11744072703209 1.66710572104191e-43 -0.838623753380888 3.81907058171582e-05 MirTarget;TargetScan -0.249677853882184 6.65837437098035e-09 NA NA NA hsa-miR-200c-3p NOG 2.07038651806183 6.84613386286599e-51 -0.838623753380888 3.81907058171582e-05 MirTarget;miRNATAP -0.347080893351845 1.63065263678635e-13 NA NA NA hsa-miR-200c-3p NOTCH1 2.07038651806183 6.84613386286599e-51 -0.553015677374277 2.02877481257167e-09 MirTarget -0.137198353882731 1.74966723790763e-10 NA NA NA hsa-miR-141-3p NOVA1 2.99777540204168 1.26370498493024e-78 -2.64865943147083 1.81019532722592e-21 miRNATAP -0.455179055575006 6.98163050399199e-17 NA NA NA hsa-miR-200b-3p NOVA1 2.11744072703209 1.66710572104191e-43 -2.64865943147083 1.81019532722592e-21 MirTarget;TargetScan -0.312507475991292 2.14282541846265e-07 NA NA NA hsa-miR-200c-3p NOVA1 2.07038651806183 6.84613386286599e-51 -2.64865943147083 1.81019532722592e-21 MirTarget;miRNATAP -0.435472416622821 3.98141218541127e-11 NA NA NA hsa-miR-200b-3p NOVA2 2.11744072703209 1.66710572104191e-43 -0.814094895411407 2.48019030681192e-17 TargetScan -0.182088283827237 3.71187269446586e-19 NA NA NA hsa-miR-141-3p NPAS3 2.99777540204168 1.26370498493024e-78 -1.77844651192273 1.0067661120746e-29 TargetScan;miRNATAP -0.242069947480667 8.29228867700514e-15 NA NA NA hsa-miR-200a-3p NPAS3 2.55218480823434 2.96135446816238e-51 -1.77844651192273 1.0067661120746e-29 miRNATAP -0.144889953989086 2.82653031116822e-06 NA NA NA hsa-miR-28-5p NPNT -0.14267073663385 0.0497619246260571 1.30537723017584 8.93205976672538e-11 miRanda -0.721622294532342 4.48461531437353e-14 NA NA NA hsa-miR-141-3p NPTX1 2.99777540204168 1.26370498493024e-78 -1.16799175041166 3.39387172426866e-07 TargetScan;miRNATAP -0.170457276662152 0.000139099213331284 NA NA NA hsa-miR-200a-3p NPTX1 2.55218480823434 2.96135446816238e-51 -1.16799175041166 3.39387172426866e-07 miRNATAP -0.154228269466061 0.000446107782490342 NA NA NA hsa-miR-200b-3p NPTX1 2.11744072703209 1.66710572104191e-43 -1.16799175041166 3.39387172426866e-07 TargetScan -0.128716549748498 0.00852590605865368 NA NA NA hsa-miR-141-3p NR3C1 2.99777540204168 1.26370498493024e-78 -1.90095759546805 1.53460991213052e-74 TargetScan -0.343681157500495 9.06380333369764e-63 NA NA NA hsa-miR-200b-3p NR3C1 2.11744072703209 1.66710572104191e-43 -1.90095759546805 1.53460991213052e-74 TargetScan -0.337372770790606 1.77296680876202e-49 NA NA NA hsa-miR-200c-3p NR3C1 2.07038651806183 6.84613386286599e-51 -1.90095759546805 1.53460991213052e-74 miRNATAP -0.371677069904956 1.11379726422763e-49 NA NA NA hsa-miR-200b-3p NR5A2 2.11744072703209 1.66710572104191e-43 -1.73641167176698 2.75266532164922e-42 TargetScan -0.34850566037163 1.6552775442547e-37 NA NA NA hsa-miR-200c-3p NR5A2 2.07038651806183 6.84613386286599e-51 -1.73641167176698 2.75266532164922e-42 miRNATAP -0.419106017589978 2.07076264682248e-45 NA NA NA hsa-miR-200b-3p NRG1 2.11744072703209 1.66710572104191e-43 -2.72776391585681 2.94582737368582e-26 TargetScan -0.31024356281559 3.0026683074848e-08 NA NA NA hsa-miR-200c-3p NRG1 2.07038651806183 6.84613386286599e-51 -2.72776391585681 2.94582737368582e-26 miRNATAP -0.323125631959935 1.57615403899138e-07 NA NA NA hsa-miR-141-3p NRP1 2.99777540204168 1.26370498493024e-78 -1.2092340225481 1.60964437652292e-34 TargetScan;miRNATAP -0.322660970639545 3.55229816484165e-69 NA NA NA hsa-miR-200a-3p NRP1 2.55218480823434 2.96135446816238e-51 -1.2092340225481 1.60964437652292e-34 miRNATAP -0.273214054014354 1.63053938383069e-49 NA NA NA hsa-miR-141-3p NRP2 2.99777540204168 1.26370498493024e-78 -0.314375201116318 0.00328594709032875 TargetScan;miRNATAP -0.20383369370909 7.86735325447486e-24 NA NA NA hsa-miR-200a-3p NRP2 2.55218480823434 2.96135446816238e-51 -0.314375201116318 0.00328594709032875 miRNATAP -0.188013235877061 4.14457924607267e-21 NA NA NA hsa-miR-200b-3p NRP2 2.11744072703209 1.66710572104191e-43 -0.314375201116318 0.00328594709032875 TargetScan -0.212257754560826 9.83458332289623e-22 NA NA NA hsa-miR-28-5p NRSN2 -0.14267073663385 0.0497619246260571 1.0077861189057 1.12746017285371e-32 miRanda -0.248146104353577 2.4591706014397e-09 NA NA NA hsa-miR-141-3p NRXN1 2.99777540204168 1.26370498493024e-78 -3.41422669412462 5.50578926594407e-34 MirTarget;TargetScan;miRNATAP -0.410752175399023 2.73817334395559e-13 NA NA NA hsa-miR-200a-3p NRXN1 2.55218480823434 2.96135446816238e-51 -3.41422669412462 5.50578926594407e-34 MirTarget;miRNATAP -0.346873612712336 3.77182743238562e-10 NA NA NA hsa-miR-200b-3p NTF3 2.11744072703209 1.66710572104191e-43 -2.35193065681614 1.75397805257351e-24 TargetScan -0.321874947951398 1.05323715646676e-10 NA NA NA hsa-miR-200c-3p NTF3 2.07038651806183 6.84613386286599e-51 -2.35193065681614 1.75397805257351e-24 miRNAWalker2_validate;miRNATAP -0.405535845133949 1.08735324650309e-13 NA NA NA hsa-miR-28-5p NTM -0.14267073663385 0.0497619246260571 0.221487289190883 0.123560204043128 miRanda;miRNATAP -0.157071376888052 0.0219271809832237 NA NA NA hsa-miR-200c-3p NTRK2 2.07038651806183 6.84613386286599e-51 -4.03565225718056 9.2986992242195e-64 miRNAWalker2_validate;miRTarBase -0.540459062838814 7.12630091174492e-20 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-141-3p NTRK3 2.99777540204168 1.26370498493024e-78 -2.79779489905708 1.23029392356612e-24 mirMAP -0.458491365569119 1.29868070797624e-17 NA NA NA hsa-miR-200a-3p NTRK3 2.55218480823434 2.96135446816238e-51 -2.79779489905708 1.23029392356612e-24 mirMAP -0.338470573748645 1.9148717552399e-10 NA NA NA hsa-miR-28-5p NUAK1 -0.14267073663385 0.0497619246260571 -0.914610809156931 1.8807905701441e-17 miRanda -0.131373331691557 0.0120066009154216 NA NA NA hsa-miR-143-3p NUAK2 -1.23248181631499 4.74160976678504e-28 2.20281585866602 3.89561828942553e-79 MirTarget;miRNATAP -0.33429583039979 4.42311186467587e-19 27081712 miR 143 inhibits oncogenic traits by degrading NUAK2 in glioblastoma glioblastoma hsa-miR-145-5p NUAK2 -2.62703571936687 7.64402900188551e-88 2.20281585866602 3.89561828942553e-79 MirTarget -0.393991012100002 1.45523667056704e-43 NA NA NA hsa-miR-28-5p NUAK2 -0.14267073663385 0.0497619246260571 2.20281585866602 3.89561828942553e-79 miRanda -0.37596435617299 7.22431489231184e-10 NA NA NA hsa-miR-28-5p NUCB2 -0.14267073663385 0.0497619246260571 0.670385380475985 8.68806334102954e-09 miRanda -0.280586626471 4.66620702358173e-07 NA NA NA hsa-miR-145-5p NUDT1 -2.62703571936687 7.64402900188551e-88 1.1327988039844 9.21559149300805e-27 miRTarBase -0.256925946439927 1.83830847661055e-25 21289483 MiR 145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1; The mRNA expressions of EGFR and NUDT1 were significantly downregulated after miR-145 transfection in human lung adenocarcinoma cells; Our results demonstrated miR-145 in the negative regulation of EGFR and NUDT1 expressions at both mRNA and protein levels; Upregulation of miR-145 appeared to be an important gene regulation mechanism for the proliferation of lung adenocarcinoma cells and it correlated strongly with the downregulation of EGFR and NUDT1; Our findings provided new insight into the complex regulating pathway comprising of miR-145 EGFR NUDT1 and other unknown factors which function in cell proliferation but not in apoptosis lung cancer hsa-miR-28-5p NUDT13 -0.14267073663385 0.0497619246260571 -0.458684101138813 1.49139282091863e-06 miRanda -0.124661710754265 0.00631011761644721 NA NA NA hsa-let-7e-5p NUDT8 0.261471269338985 0.00191077095550257 -0.13517503992748 0.428648427443961 miRNAWalker2_validate -0.363889825067688 1.58385949691265e-07 NA NA NA hsa-miR-132-3p NVL -0.0365213889238607 0.668598301088667 1.20560213281561 2.67585067617384e-50 MirTarget -0.176219330977305 3.68089536545484e-07 NA NA NA hsa-miR-132-3p OAS2 -0.0365213889238607 0.668598301088667 1.17346164591443 5.93578964327051e-14 miRNAWalker2_validate -0.267095614113891 3.08705948967938e-05 NA NA NA hsa-miR-141-3p OLFM1 2.99777540204168 1.26370498493024e-78 -0.806833993567473 2.33080631095537e-05 MirTarget;TargetScan;miRNATAP -0.203164969416503 3.98805762929319e-08 NA NA NA hsa-miR-200a-3p OLFM1 2.55218480823434 2.96135446816238e-51 -0.806833993567473 2.33080631095537e-05 MirTarget;miRNATAP -0.161242066229165 9.49214433672516e-06 NA NA NA hsa-miR-28-5p OLFM1 -0.14267073663385 0.0497619246260571 -0.806833993567473 2.33080631095537e-05 miRanda -0.434330191870437 1.74743829260296e-06 NA NA NA hsa-miR-141-3p OLFML2A 2.99777540204168 1.26370498493024e-78 -1.23279838858358 1.44822780058179e-34 mirMAP -0.255375418553711 1.92866577906841e-39 NA NA NA hsa-miR-200a-3p OLFML2A 2.55218480823434 2.96135446816238e-51 -1.23279838858358 1.44822780058179e-34 mirMAP -0.202472969940008 1.899890371669e-25 NA NA NA hsa-miR-28-5p OLFML3 -0.14267073663385 0.0497619246260571 -0.484779181334281 4.26190141017196e-05 miRanda -0.146634750872719 0.00964142489546047 NA NA NA hsa-miR-145-5p ONECUT2 -2.62703571936687 7.64402900188551e-88 0.838418671812549 0.0134553608090962 mirMAP;miRNATAP -0.186900423670462 0.0179286823151424 NA NA NA hsa-miR-205-5p ONECUT2 -1.70057043266505 1.20976599540743e-09 0.838418671812549 0.0134553608090962 mirMAP -0.155526069725065 0.000152029008415942 NA NA NA hsa-miR-28-5p OPRL1 -0.14267073663385 0.0497619246260571 0.49783574876775 5.13471543214715e-06 mirMAP -0.233641833736997 7.2289784919858e-06 NA NA NA hsa-miR-28-5p OSBPL10 -0.14267073663385 0.0497619246260571 -0.0654040479624038 0.460318540732145 miRanda -0.114725848755068 0.00646868684724235 NA NA NA hsa-miR-200b-3p OSBPL11 2.11744072703209 1.66710572104191e-43 -0.367137294663096 1.23945889750395e-08 MirTarget;TargetScan -0.105453058697228 7.28318528942807e-15 NA NA NA hsa-miR-200c-3p OSBPL11 2.07038651806183 6.84613386286599e-51 -0.367137294663096 1.23945889750395e-08 MirTarget;miRNATAP -0.104825958660084 2.3997622115761e-12 NA NA NA hsa-miR-141-3p OSBPL1A 2.99777540204168 1.26370498493024e-78 -1.13066391229894 4.52776339430695e-36 TargetScan -0.121306246132155 2.15527685962491e-11 NA NA NA hsa-let-7e-5p OSBPL3 0.261471269338985 0.00191077095550257 0.171454623993056 0.119467208431099 miRNATAP -0.114873887553007 0.010747052370391 NA NA NA hsa-miR-200a-3p OSBPL6 2.55218480823434 2.96135446816238e-51 0.353016330690283 0.0415531126921937 MirTarget;miRNATAP -0.118363724930756 0.000334864651178065 NA NA NA hsa-miR-200b-3p OSBPL6 2.11744072703209 1.66710572104191e-43 0.353016330690283 0.0415531126921937 mirMAP -0.100093368453257 0.00647596894415949 NA NA NA hsa-miR-28-5p OSBPL7 -0.14267073663385 0.0497619246260571 0.0588084177089319 0.550542377722673 miRanda -0.160386070710978 0.000610888019257143 NA NA NA hsa-miR-132-3p OSBPL8 -0.0365213889238607 0.668598301088667 -0.597116166688471 4.67806844867655e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.122348190300177 0.00328898023138446 NA NA NA hsa-miR-141-3p OSBPL8 2.99777540204168 1.26370498493024e-78 -0.597116166688471 4.67806844867655e-09 MirTarget -0.103660628751314 1.82391401359925e-07 NA NA NA hsa-miR-200b-3p OSMR 2.11744072703209 1.66710572104191e-43 -0.668362253183246 2.80577564076125e-06 TargetScan -0.20408879563362 1.18112518586047e-11 NA NA NA hsa-miR-200b-3p OSR1 2.11744072703209 1.66710572104191e-43 -3.16852677493185 4.80968425126363e-31 TargetScan -0.292970121454762 1.04579720835767e-06 NA NA NA hsa-miR-200c-3p OSR1 2.07038651806183 6.84613386286599e-51 -3.16852677493185 4.80968425126363e-31 miRNATAP -0.443368946680984 1.34911561063052e-11 NA NA NA hsa-miR-200b-3p OSTM1 2.11744072703209 1.66710572104191e-43 -0.528607916390317 6.96950270756952e-16 MirTarget;TargetScan -0.176145840991316 4.22722946472316e-39 NA NA NA hsa-miR-200c-3p OSTM1 2.07038651806183 6.84613386286599e-51 -0.528607916390317 6.96950270756952e-16 MirTarget -0.208993700977901 5.00724824993472e-46 NA NA NA hsa-let-7e-5p OTOF 0.261471269338985 0.00191077095550257 -0.196207708074429 0.341699533090777 miRNATAP -0.224182434201044 0.00789832113245597 NA NA NA hsa-miR-28-5p OTUB1 -0.14267073663385 0.0497619246260571 0.743708114973462 2.76727756237135e-34 miRNAWalker2_validate;miRTarBase;PITA;miRNATAP -0.114501198557697 0.000145943210829922 NA NA NA hsa-miR-28-5p OTUB2 -0.14267073663385 0.0497619246260571 1.04819143562664 1.51953841962343e-30 miRanda -0.149357921381267 0.000915308983616309 NA NA NA hsa-miR-28-5p OTUD7B -0.14267073663385 0.0497619246260571 0.287248124272624 8.35565629206682e-05 PITA -0.199526477493703 8.04398758407007e-09 NA NA NA hsa-miR-141-3p P2RX6 2.99777540204168 1.26370498493024e-78 -2.54903747820754 2.16948536748351e-36 mirMAP -0.449371623952927 1.2120829487478e-29 NA NA NA hsa-miR-200a-3p P2RX6 2.55218480823434 2.96135446816238e-51 -2.54903747820754 2.16948536748351e-36 mirMAP -0.350136112048884 8.61282914522302e-19 NA NA NA hsa-miR-141-3p P2RY1 2.99777540204168 1.26370498493024e-78 -0.850118686903185 2.14298043474504e-07 TargetScan -0.268507511975452 1.48074248609534e-17 NA NA NA hsa-miR-28-5p PAFAH2 -0.14267073663385 0.0497619246260571 0.274540087069485 2.25730801999012e-05 MirTarget;miRanda -0.181474588639603 3.33470892114403e-09 NA NA NA hsa-miR-132-3p PAIP2 -0.0365213889238607 0.668598301088667 -0.0443061200808774 0.39649834099352 MirTarget -0.105000144763599 5.50092782577906e-07 NA NA NA hsa-miR-200b-3p PAK3 2.11744072703209 1.66710572104191e-43 -3.72979901479568 2.02151045164573e-57 TargetScan -0.377458116576707 7.1482577050122e-13 NA NA NA hsa-miR-145-5p PAK4 -2.62703571936687 7.64402900188551e-88 1.47186288644382 7.37718156197043e-58 miRNAWalker2_validate;miRTarBase -0.326408303596423 4.52801469396177e-52 23499891 We further demonstrated that miR-145 directly targeted catenin δ-1 contributing to the aberrant translocation of β-catenin through impaired nuclear shuttling with p21-activated kinase 4 PAK4 colon cancer hsa-miR-200b-3p PALM2 2.11744072703209 1.66710572104191e-43 -0.653931714558236 2.40323003337382e-05 TargetScan -0.171817597461909 1.6125973826136e-07 NA NA NA hsa-miR-141-3p PALM2-AKAP2 2.99777540204168 1.26370498493024e-78 -2.18061520132683 2.36003120512481e-93 TargetScan;miRNATAP -0.412788028638882 3.72804347535648e-87 NA NA NA hsa-miR-200a-3p PALM2-AKAP2 2.55218480823434 2.96135446816238e-51 -2.18061520132683 2.36003120512481e-93 miRNATAP -0.334520266778723 1.49700561854671e-55 NA NA NA hsa-miR-200b-3p PALM2-AKAP2 2.11744072703209 1.66710572104191e-43 -2.18061520132683 2.36003120512481e-93 TargetScan -0.361522510969298 4.2525667342449e-52 NA NA NA hsa-miR-200c-3p PALM2-AKAP2 2.07038651806183 6.84613386286599e-51 -2.18061520132683 2.36003120512481e-93 miRNATAP -0.446952227497301 4.95966968545459e-68 NA NA NA hsa-miR-200b-3p PAM 2.11744072703209 1.66710572104191e-43 -0.95135206643246 1.04094267312042e-17 TargetScan -0.200182296378385 2.08577420531689e-17 NA NA NA hsa-miR-200c-3p PAM 2.07038651806183 6.84613386286599e-51 -0.95135206643246 1.04094267312042e-17 miRNATAP -0.255377027741016 3.26611360579356e-23 NA NA NA hsa-miR-28-5p PAN2 -0.14267073663385 0.0497619246260571 -0.417044459562392 2.76743472392804e-09 miRanda -0.17925739666463 8.53714401819021e-08 NA NA NA hsa-miR-141-3p PAPLN 2.99777540204168 1.26370498493024e-78 -0.934616468378652 1.68697270659172e-12 TargetScan -0.251246552133318 4.78996719843743e-23 NA NA NA hsa-miR-200b-3p PAPLN 2.11744072703209 1.66710572104191e-43 -0.934616468378652 1.68697270659172e-12 TargetScan -0.18607595576945 3.98686757828339e-11 NA NA NA hsa-miR-141-3p PAPPA 2.99777540204168 1.26370498493024e-78 -0.728679548360849 1.50074730316036e-06 MirTarget;TargetScan;miRNATAP -0.257212200581169 7.50120124816377e-19 NA NA NA hsa-miR-200a-3p PAPPA 2.55218480823434 2.96135446816238e-51 -0.728679548360849 1.50074730316036e-06 MirTarget;miRNATAP -0.225418193938018 3.20106293266592e-15 NA NA NA hsa-miR-200b-3p PARD3B 2.11744072703209 1.66710572104191e-43 -1.79470831891467 1.2314875552622e-23 MirTarget;TargetScan;mirMAP -0.305639472422353 1.91199782696716e-15 NA NA NA hsa-miR-200c-3p PARD3B 2.07038651806183 6.84613386286599e-51 -1.79470831891467 1.2314875552622e-23 MirTarget;miRNATAP -0.351954866959227 7.59360613509706e-17 NA NA NA hsa-let-7e-5p PARM1 0.261471269338985 0.00191077095550257 -1.52406675705941 4.35164695925674e-28 MirTarget -0.131382246872703 0.0253615209544231 NA NA NA hsa-let-7e-5p PARP8 0.261471269338985 0.00191077095550257 -0.455686342314426 0.000606041961716729 miRNATAP -0.190399840343885 0.000467753962409075 NA NA NA hsa-miR-143-3p PARP9 -1.23248181631499 4.74160976678504e-28 0.82454603657354 3.53970648717232e-19 mirMAP -0.180342746171717 6.18867141060291e-11 NA NA NA hsa-miR-28-5p PAX2 -0.14267073663385 0.0497619246260571 1.8599254035637 2.52708224268088e-08 mirMAP -1.06941300758972 1.56234760375969e-11 NA NA NA hsa-miR-141-3p PAX3 2.99777540204168 1.26370498493024e-78 -2.25919597564541 4.32944093751082e-20 TargetScan -0.452976558660758 2.86306645105671e-21 NA NA NA hsa-miR-145-5p PAX7 -2.62703571936687 7.64402900188551e-88 2.03652915781352 2.5484159291376e-07 mirMAP -0.405651123505753 1.07184308208549e-05 NA NA NA hsa-miR-132-3p PBX1 -0.0365213889238607 0.668598301088667 0.383124547914576 0.000939101086871089 mirMAP -0.283045424648147 1.23859145547734e-09 NA NA NA hsa-miR-200b-3p PCDH10 2.11744072703209 1.66710572104191e-43 -0.589847783454892 0.0702331583145207 MirTarget -0.26151206086216 0.000150819811898916 NA NA NA hsa-miR-200c-3p PCDH10 2.07038651806183 6.84613386286599e-51 -0.589847783454892 0.0702331583145207 MirTarget -0.288094659975668 0.000146644199276303 NA NA NA hsa-miR-28-5p PCDH10 -0.14267073663385 0.0497619246260571 -0.589847783454892 0.0702331583145207 miRanda -0.538818734654809 0.000511157836185964 NA NA NA hsa-miR-200b-3p PCDH19 2.11744072703209 1.66710572104191e-43 -2.01847089352803 5.92265974145112e-23 TargetScan -0.331795782186515 4.5797341350269e-14 NA NA NA hsa-miR-200c-3p PCDH19 2.07038651806183 6.84613386286599e-51 -2.01847089352803 5.92265974145112e-23 miRNATAP -0.465837102503143 2.07114735399684e-22 NA NA NA hsa-miR-200b-3p PCDH7 2.11744072703209 1.66710572104191e-43 -0.38249739786875 0.0153349818675969 TargetScan -0.231512878559724 2.63345000116007e-12 NA NA NA hsa-miR-141-3p PCDH9 2.99777540204168 1.26370498493024e-78 -3.83392224636774 3.81147875867783e-64 MirTarget;miRNATAP -0.681415894788408 3.41632346531745e-52 NA NA NA hsa-miR-200a-3p PCDH9 2.55218480823434 2.96135446816238e-51 -3.83392224636774 3.81147875867783e-64 MirTarget;miRNATAP -0.553621618862474 8.33652706345163e-35 NA NA NA hsa-miR-141-3p PCGF5 2.99777540204168 1.26370498493024e-78 -0.885572387235352 3.41102487287495e-33 MirTarget -0.114564683868903 6.2908018056077e-15 NA NA NA hsa-miR-200b-3p PCSK2 2.11744072703209 1.66710572104191e-43 -1.42424996634036 3.40373694425593e-05 TargetScan -0.294748227645407 5.4496275666322e-05 NA NA NA hsa-miR-200c-3p PCSK2 2.07038651806183 6.84613386286599e-51 -1.42424996634036 3.40373694425593e-05 miRNATAP -0.389154981000866 1.20004504496534e-06 NA NA NA hsa-miR-200b-3p PCSK5 2.11744072703209 1.66710572104191e-43 -1.92996085102886 3.3455070654901e-31 TargetScan -0.460555630923708 8.7985776699295e-40 NA NA NA hsa-miR-28-5p PCSK6 -0.14267073663385 0.0497619246260571 0.33169561953974 0.0771775975214687 miRanda -0.325068253320658 0.000271228066827847 NA NA NA hsa-miR-28-5p PCYOX1 -0.14267073663385 0.0497619246260571 -1.09884998986409 7.48295373511972e-39 miRanda -0.135347671586706 0.00129452200167461 NA NA NA hsa-miR-28-5p PCYOX1L -0.14267073663385 0.0497619246260571 0.554225987753898 5.61819495077454e-16 miRanda -0.190735646180457 6.71716832065865e-09 NA NA NA hsa-miR-200b-3p PDE10A 2.11744072703209 1.66710572104191e-43 -0.585329690276131 3.9584796407678e-05 mirMAP -0.229661031753558 1.50901534886657e-14 NA NA NA hsa-miR-200c-3p PDE10A 2.07038651806183 6.84613386286599e-51 -0.585329690276131 3.9584796407678e-05 mirMAP -0.261178672318255 1.72791535704395e-15 NA NA NA hsa-miR-141-3p PDE1C 2.99777540204168 1.26370498493024e-78 -3.9471279332945 1.74355712680188e-60 mirMAP -0.513217876946579 1.18637564792511e-25 NA NA NA hsa-miR-200a-3p PDE1C 2.55218480823434 2.96135446816238e-51 -3.9471279332945 1.74355712680188e-60 mirMAP -0.390892494128905 1.04247738122523e-15 NA NA NA hsa-miR-28-5p PDE4A -0.14267073663385 0.0497619246260571 -0.10844696857969 0.381039125696737 miRanda -0.227281107486484 0.000110708900233232 NA NA NA hsa-miR-200b-3p PDE4D 2.11744072703209 1.66710572104191e-43 -0.515867337472647 0.000105517780035465 mirMAP -0.19058210162814 9.9443247546046e-12 NA NA NA hsa-miR-200c-3p PDE4D 2.07038651806183 6.84613386286599e-51 -0.515867337472647 0.000105517780035465 mirMAP -0.177507320297067 9.29083994916719e-09 NA NA NA hsa-miR-200c-3p PDE5A 2.07038651806183 6.84613386286599e-51 -1.75867073177592 2.55136534038232e-29 miRNATAP -0.272409753840994 2.91975746364297e-13 NA NA NA hsa-miR-200b-3p PDE7B 2.11744072703209 1.66710572104191e-43 -1.8192986932678 4.14918988039866e-48 TargetScan -0.348600223874175 1.44238454289598e-38 NA NA NA hsa-miR-200c-3p PDE7B 2.07038651806183 6.84613386286599e-51 -1.8192986932678 4.14918988039866e-48 miRNATAP -0.434760282901556 1.28232495346798e-50 NA NA NA hsa-miR-141-3p PDGFRA 2.99777540204168 1.26370498493024e-78 -1.84169721584144 2.50038285124215e-31 MirTarget -0.465703815469129 7.78017639246501e-55 NA NA NA hsa-miR-200a-3p PDGFRA 2.55218480823434 2.96135446816238e-51 -1.84169721584144 2.50038285124215e-31 MirTarget -0.404359885272289 5.76229938736958e-42 NA NA NA hsa-miR-28-5p PDGFRB -0.14267073663385 0.0497619246260571 -0.363053423609744 0.000930448280520273 miRanda -0.106080049561343 0.0428915822633876 NA NA NA hsa-miR-200a-3p PDK2 2.55218480823434 2.96135446816238e-51 -0.829357718034116 1.58708871081625e-18 mirMAP -0.112275719100424 7.29954656187263e-10 NA NA NA hsa-miR-28-5p PDPK1 -0.14267073663385 0.0497619246260571 -0.0553897078043679 0.47893230919387 mirMAP -0.188098133932334 3.6777139194769e-07 NA NA NA hsa-miR-145-5p PDXDC1 -2.62703571936687 7.64402900188551e-88 0.867679818835133 1.64124821154065e-33 MirTarget -0.136398263430833 1.55224555909963e-15 NA NA NA hsa-miR-28-5p PDXDC1 -0.14267073663385 0.0497619246260571 0.867679818835133 1.64124821154065e-33 miRanda -0.20421343833345 7.92479068630763e-09 NA NA NA hsa-miR-141-3p PDZD2 2.99777540204168 1.26370498493024e-78 -2.76417153731067 5.68349864068644e-65 TargetScan -0.521797399474431 1.49797675214627e-60 NA NA NA hsa-miR-141-3p PEG3 2.99777540204168 1.26370498493024e-78 -1.76855555357171 1.41302613452224e-11 TargetScan -0.245831360280799 1.65786809256862e-06 NA NA NA hsa-miR-200a-3p PELI2 2.55218480823434 2.96135446816238e-51 -2.1370288071573 1.71637344970085e-56 mirMAP -0.313508299910822 4.55908828462781e-32 NA NA NA hsa-miR-28-5p PEX12 -0.14267073663385 0.0497619246260571 -0.244701247391237 0.00249870618819211 miRanda -0.269940810394297 1.38504482563852e-12 NA NA NA hsa-miR-28-5p PFKM -0.14267073663385 0.0497619246260571 -0.167575311099228 0.0685593901261937 miRanda;miRNATAP -0.116393774331497 0.00788145315345331 NA NA NA hsa-miR-200b-3p PGAP1 2.11744072703209 1.66710572104191e-43 -1.31559839003994 2.62464485048632e-27 mirMAP -0.211297291563601 7.38128913714327e-16 NA NA NA hsa-miR-28-5p PGP -0.14267073663385 0.0497619246260571 1.28708655220271 1.99547006668391e-44 mirMAP -0.263325481764824 1.02820054287834e-08 NA NA NA hsa-miR-200b-3p PHACTR2 2.11744072703209 1.66710572104191e-43 -1.0916982358773 4.3094820433717e-28 MirTarget -0.253075663375176 1.21293959109688e-33 NA NA NA hsa-miR-200c-3p PHACTR2 2.07038651806183 6.84613386286599e-51 -1.0916982358773 4.3094820433717e-28 MirTarget;miRNATAP -0.249569509159602 6.22668441783385e-27 NA NA NA hsa-miR-200b-3p PHACTR3 2.11744072703209 1.66710572104191e-43 -0.558869946890798 0.00128355217613313 MirTarget;TargetScan -0.141052439212467 0.000128160137346357 NA NA NA hsa-miR-200c-3p PHACTR3 2.07038651806183 6.84613386286599e-51 -0.558869946890798 0.00128355217613313 MirTarget;miRNATAP -0.191995024047058 2.01532175699045e-06 NA NA NA hsa-miR-200b-3p PHEX 2.11744072703209 1.66710572104191e-43 0.563027895897396 0.00624446021292856 MirTarget -0.100334825094466 0.0218911356211177 NA NA NA hsa-miR-143-3p PHF6 -1.23248181631499 4.74160976678504e-28 0.289673557327313 0.000100808315441901 MirTarget;miRNATAP -0.113786087798222 2.2245366897438e-07 NA NA NA hsa-miR-132-3p PHKA1 -0.0365213889238607 0.668598301088667 0.381013634747799 3.54604148762824e-05 mirMAP -0.133569830035259 0.000352822184872703 NA NA NA hsa-miR-28-5p PHKB -0.14267073663385 0.0497619246260571 -0.474811813850328 3.42461136633396e-10 miRanda -0.111196268170306 0.0022176267680483 NA NA NA hsa-miR-28-5p PHKG2 -0.14267073663385 0.0497619246260571 1.17584598160819 7.15388386958662e-52 miRanda -0.201461578928291 2.7542518948257e-07 NA NA NA hsa-miR-200b-3p PHLDB1 2.11744072703209 1.66710572104191e-43 -1.04573367086873 2.72515970448509e-38 MirTarget;TargetScan -0.234096978292779 6.33415993581434e-43 NA NA NA hsa-miR-200c-3p PHLDB1 2.07038651806183 6.84613386286599e-51 -1.04573367086873 2.72515970448509e-38 MirTarget;miRNATAP -0.320341173447904 4.08141116217833e-70 NA NA NA hsa-miR-145-5p PHRF1 -2.62703571936687 7.64402900188551e-88 0.397148160140797 3.15615876944519e-08 MirTarget;miRNATAP -0.160290305058655 1.13216870565306e-22 NA NA NA hsa-miR-141-3p PHYHIPL 2.99777540204168 1.26370498493024e-78 -2.11508828895346 7.32933510596028e-24 MirTarget;TargetScan;miRNATAP -0.334168282042049 6.0501781021457e-16 NA NA NA hsa-miR-200a-3p PHYHIPL 2.55218480823434 2.96135446816238e-51 -2.11508828895346 7.32933510596028e-24 MirTarget;miRNATAP -0.26342496745624 1.09105832303384e-10 NA NA NA hsa-miR-200b-3p PICALM 2.11744072703209 1.66710572104191e-43 -0.627041785265885 1.50198956736942e-24 MirTarget -0.130198912876829 1.42356613610767e-23 NA NA NA hsa-miR-200c-3p PICALM 2.07038651806183 6.84613386286599e-51 -0.627041785265885 1.50198956736942e-24 MirTarget -0.144940267147938 3.74395849781387e-24 NA NA NA hsa-miR-28-5p PIGG -0.14267073663385 0.0497619246260571 0.107993711309021 0.0641318638666071 miRanda -0.156799939519724 1.20811913049496e-08 NA NA NA hsa-miR-28-5p PIGO -0.14267073663385 0.0497619246260571 0.632201925119523 4.99557211163621e-21 miRanda -0.189309260037223 5.74895962733358e-09 NA NA NA hsa-miR-200b-3p PIK3CA 2.11744072703209 1.66710572104191e-43 -0.881957552231161 1.15529457057533e-22 TargetScan -0.164394431071602 1.25931440199374e-17 NA NA NA hsa-miR-132-3p PIK3R1 -0.0365213889238607 0.668598301088667 -1.70627489565512 1.28475917565256e-44 MirTarget -0.121882557287893 0.0194776509799562 NA NA NA hsa-miR-200b-3p PIK3R1 2.11744072703209 1.66710572104191e-43 -1.70627489565512 1.28475917565256e-44 mirMAP -0.193888157381114 6.36921236487692e-13 NA NA NA hsa-miR-200c-3p PIK3R1 2.07038651806183 6.84613386286599e-51 -1.70627489565512 1.28475917565256e-44 mirMAP -0.257145031020416 2.3912254219973e-18 NA NA NA hsa-miR-28-5p PIK3R2 -0.14267073663385 0.0497619246260571 1.28293433832686 8.5972816204378e-73 miRanda -0.170225138245223 4.06181677270291e-06 NA NA NA hsa-miR-28-5p PIK3R3 -0.14267073663385 0.0497619246260571 0.559172960265555 3.98014986716526e-09 miRanda -0.112036735701901 0.0141687305542462 NA NA NA hsa-miR-141-3p PIKFYVE 2.99777540204168 1.26370498493024e-78 -0.856697691591447 3.59347529295631e-24 MirTarget -0.136376911845397 2.08057028047207e-16 NA NA NA hsa-miR-200a-3p PIKFYVE 2.55218480823434 2.96135446816238e-51 -0.856697691591447 3.59347529295631e-24 MirTarget -0.121096803902981 1.26460022019514e-13 NA NA NA hsa-miR-200b-3p PIKFYVE 2.11744072703209 1.66710572104191e-43 -0.856697691591447 3.59347529295631e-24 MirTarget;TargetScan -0.132349216178503 3.41125325851376e-13 NA NA NA hsa-miR-200c-3p PIKFYVE 2.07038651806183 6.84613386286599e-51 -0.856697691591447 3.59347529295631e-24 MirTarget;miRNATAP -0.142430317245247 1.10361204942165e-12 NA NA NA hsa-miR-28-5p PIP4K2C -0.14267073663385 0.0497619246260571 0.785545156337934 1.33112420136684e-29 miRanda -0.201400552827145 3.19497519827677e-09 NA NA NA hsa-miR-141-3p PITX2 2.99777540204168 1.26370498493024e-78 -0.446534217465074 0.0204393455572554 TargetScan;miRNATAP -0.223717264715575 1.74572061948343e-09 NA NA NA hsa-miR-200a-3p PITX2 2.55218480823434 2.96135446816238e-51 -0.446534217465074 0.0204393455572554 miRNATAP -0.2225102743152 1.03072167409031e-09 NA NA NA hsa-miR-132-3p PKD1L1 -0.0365213889238607 0.668598301088667 -1.13731177018652 2.11216301823645e-15 MirTarget -0.120315609389711 0.041890358074265 NA NA NA hsa-miR-200a-3p PKIA 2.55218480823434 2.96135446816238e-51 -1.53571066596047 4.62934386564947e-14 mirMAP -0.361517924934796 6.63134739334438e-21 NA NA NA hsa-miR-200b-3p PKIA 2.11744072703209 1.66710572104191e-43 -1.53571066596047 4.62934386564947e-14 MirTarget;TargetScan -0.35239894901475 3.09338480263276e-16 NA NA NA hsa-miR-200c-3p PKIA 2.07038651806183 6.84613386286599e-51 -1.53571066596047 4.62934386564947e-14 MirTarget;miRNATAP -0.36206104356032 2.66841796132117e-14 NA NA NA hsa-miR-141-3p PLA2R1 2.99777540204168 1.26370498493024e-78 -1.74661378073068 1.09491748872223e-46 mirMAP -0.290912341077658 1.49547340397695e-33 NA NA NA hsa-miR-141-3p PLAG1 2.99777540204168 1.26370498493024e-78 -1.22970054692881 5.65960696224232e-15 TargetScan;miRNATAP -0.195363034371323 2.35535488719952e-10 NA NA NA hsa-miR-200a-3p PLAG1 2.55218480823434 2.96135446816238e-51 -1.22970054692881 5.65960696224232e-15 miRNATAP -0.182152441306119 1.80422008866561e-09 NA NA NA hsa-miR-143-3p PLAGL2 -1.23248181631499 4.74160976678504e-28 0.317236875342579 2.17599167893943e-07 mirMAP;miRNATAP -0.132289683943401 1.70303930376782e-13 NA NA NA hsa-miR-143-3p PLAUR -1.23248181631499 4.74160976678504e-28 1.72201143929991 8.4340887072744e-43 miRNATAP -0.101588354654431 0.00958055588827153 NA NA NA hsa-let-7e-5p PLCB4 0.261471269338985 0.00191077095550257 -0.971426359987884 2.28823451814059e-07 miRNATAP -0.194802452833621 0.0118202484022476 NA NA NA hsa-miR-141-3p PLCB4 2.99777540204168 1.26370498493024e-78 -0.971426359987884 2.28823451814059e-07 TargetScan -0.129122335963341 0.000435434137519319 NA NA NA hsa-miR-28-5p PLCD4 -0.14267073663385 0.0497619246260571 0.135354827465335 0.311825654751022 miRanda -0.503044438055499 9.77066808847889e-16 NA NA NA hsa-miR-141-3p PLCL1 2.99777540204168 1.26370498493024e-78 -0.861592973460026 2.13570934923443e-07 MirTarget;TargetScan -0.220218414690715 7.35851061939504e-12 NA NA NA hsa-miR-200a-3p PLCL1 2.55218480823434 2.96135446816238e-51 -0.861592973460026 2.13570934923443e-07 MirTarget -0.179921519453597 1.34473772332191e-08 NA NA NA hsa-miR-200b-3p PLCL1 2.11744072703209 1.66710572104191e-43 -0.861592973460026 2.13570934923443e-07 MirTarget;TargetScan -0.186560505331726 1.23050603915014e-07 NA NA NA hsa-miR-200c-3p PLCL1 2.07038651806183 6.84613386286599e-51 -0.861592973460026 2.13570934923443e-07 MirTarget -0.277039669837228 6.37214256514421e-13 NA NA NA hsa-let-7e-5p PLCXD3 0.261471269338985 0.00191077095550257 -3.5618826851907 6.32920306664313e-37 miRNATAP -0.435487324120043 0.000284951389542313 NA NA NA hsa-miR-141-3p PLCXD3 2.99777540204168 1.26370498493024e-78 -3.5618826851907 6.32920306664313e-37 TargetScan;miRNATAP -0.819970693742895 4.97187894848886e-53 NA NA NA hsa-miR-200a-3p PLCXD3 2.55218480823434 2.96135446816238e-51 -3.5618826851907 6.32920306664313e-37 miRNATAP -0.609698480165206 1.97732293811626e-29 NA NA NA hsa-miR-200b-3p PLCXD3 2.11744072703209 1.66710572104191e-43 -3.5618826851907 6.32920306664313e-37 TargetScan -0.611157162653787 6.94552205471737e-24 NA NA NA hsa-miR-141-3p PLEK 2.99777540204168 1.26370498493024e-78 0.170820097329674 0.196220259814462 MirTarget;TargetScan -0.100345357365683 8.98816706507767e-05 NA NA NA hsa-let-7e-5p PLEKHG6 0.261471269338985 0.00191077095550257 -0.804402259067752 3.35350601516728e-08 MirTarget;miRNATAP -0.122744178850307 0.0412341855886767 NA NA NA hsa-miR-28-5p PLEKHH1 -0.14267073663385 0.0497619246260571 -0.261980470817113 0.0364210745908391 miRanda -0.142488673730933 0.0169848340831966 NA NA NA hsa-miR-200b-3p PLEKHM3 2.11744072703209 1.66710572104191e-43 -1.84131497880035 1.34528076669196e-67 MirTarget;TargetScan -0.241333647212449 3.86287713007947e-24 NA NA NA hsa-miR-200c-3p PLEKHM3 2.07038651806183 6.84613386286599e-51 -1.84131497880035 1.34528076669196e-67 MirTarget -0.287353017866813 2.59577926133476e-28 NA NA NA hsa-miR-200b-3p PLS3 2.11744072703209 1.66710572104191e-43 -1.1188566933368 4.91386750614017e-22 TargetScan -0.281881276242237 4.81447933812582e-31 NA NA NA hsa-miR-141-3p PLXDC1 2.99777540204168 1.26370498493024e-78 -0.181187214482674 0.0645908903217389 TargetScan -0.158737173761504 2.02327874595318e-17 NA NA NA hsa-miR-200b-3p PLXNA2 2.11744072703209 1.66710572104191e-43 -0.293557303793948 0.00573633661157915 TargetScan -0.127054491842765 1.40894493883852e-08 NA NA NA hsa-miR-141-3p PLXNA4 2.99777540204168 1.26370498493024e-78 -3.24060572750455 3.5769955557962e-61 TargetScan;miRNATAP -0.638005395400365 8.80013447469558e-63 NA NA NA hsa-miR-200a-3p PLXNA4 2.55218480823434 2.96135446816238e-51 -3.24060572750455 3.5769955557962e-61 mirMAP;miRNATAP -0.520118939371117 1.17337551468408e-41 NA NA NA hsa-miR-200b-3p PLXNA4 2.11744072703209 1.66710572104191e-43 -3.24060572750455 3.5769955557962e-61 TargetScan -0.560429430413497 6.14792482365742e-39 NA NA NA hsa-miR-200c-3p PLXNA4 2.07038651806183 6.84613386286599e-51 -3.24060572750455 3.5769955557962e-61 miRNATAP -0.695362378238331 1.50531990318095e-50 NA NA NA hsa-miR-141-3p PLXNC1 2.99777540204168 1.26370498493024e-78 -0.138164570454698 0.490888361136795 TargetScan;miRNATAP -0.197318592223399 3.55833404294406e-07 NA NA NA hsa-miR-200a-3p PLXNC1 2.55218480823434 2.96135446816238e-51 -0.138164570454698 0.490888361136795 miRNATAP -0.192251312941787 4.29328184204721e-07 NA NA NA hsa-miR-200b-3p PLXNC1 2.11744072703209 1.66710572104191e-43 -0.138164570454698 0.490888361136795 TargetScan -0.195053227062515 4.1104191023972e-06 NA NA NA hsa-miR-200c-3p PLXNC1 2.07038651806183 6.84613386286599e-51 -0.138164570454698 0.490888361136795 miRNATAP -0.195025765062541 2.87438108523045e-05 NA NA NA hsa-miR-28-5p PMPCA -0.14267073663385 0.0497619246260571 0.52698682555574 5.78301134193271e-17 miRanda -0.119185297110825 9.09650178789744e-05 NA NA NA hsa-miR-141-3p PNMA3 2.99777540204168 1.26370498493024e-78 -0.863176542925314 0.000585799145434105 MirTarget -0.136698359647499 0.00522332015187694 NA NA NA hsa-miR-200a-3p PNMA3 2.55218480823434 2.96135446816238e-51 -0.863176542925314 0.000585799145434105 MirTarget -0.122129919598298 0.0110110742443319 NA NA NA hsa-miR-143-3p POGK -1.23248181631499 4.74160976678504e-28 0.801674980396631 1.88660264507077e-33 MirTarget -0.158733506285951 3.40835686094818e-15 NA NA NA hsa-miR-132-3p POGZ -0.0365213889238607 0.668598301088667 0.221455188654849 0.000545925051104238 MirTarget -0.104414549340314 5.50225190579859e-05 NA NA NA hsa-miR-132-3p POLK -0.0365213889238607 0.668598301088667 -0.643740598724049 1.80887720530213e-15 miRNAWalker2_validate -0.106925678594733 0.00132163197833319 NA NA NA hsa-miR-200c-3p POLK 2.07038651806183 6.84613386286599e-51 -0.643740598724049 1.80887720530213e-15 MirTarget -0.119652805346443 3.12161470814839e-10 NA NA NA hsa-miR-132-3p POU2F1 -0.0365213889238607 0.668598301088667 0.185892579424663 0.041572265516766 mirMAP -0.180422608885481 9.10627395613614e-07 NA NA NA hsa-let-7e-5p POU2F2 0.261471269338985 0.00191077095550257 0.150059201849073 0.217506360049201 miRNATAP -0.173757330951836 0.000468944957117842 NA NA NA hsa-miR-200b-3p POU6F1 2.11744072703209 1.66710572104191e-43 -1.22160046868415 5.22496483078127e-46 TargetScan -0.160259866602277 2.30858415043228e-17 NA NA NA hsa-let-7e-5p PPARA 0.261471269338985 0.00191077095550257 -1.66915873925688 2.97363179285551e-46 miRNATAP -0.169158901043786 0.000831589068211498 NA NA NA hsa-miR-141-3p PPARA 2.99777540204168 1.26370498493024e-78 -1.66915873925688 2.97363179285551e-46 miRNAWalker2_validate;miRTarBase -0.247904615736715 2.4815889948105e-26 NA NA NA hsa-miR-200b-3p PPARA 2.11744072703209 1.66710572104191e-43 -1.66915873925688 2.97363179285551e-46 MirTarget -0.259376542668734 3.26243338968945e-24 NA NA NA hsa-miR-200c-3p PPARA 2.07038651806183 6.84613386286599e-51 -1.66915873925688 2.97363179285551e-46 MirTarget -0.290578862789838 3.98530929459165e-25 NA NA NA hsa-miR-200a-3p PPARGC1A 2.55218480823434 2.96135446816238e-51 -2.61634087589818 7.44821426380706e-32 mirMAP -0.313568601776736 6.61298144545941e-13 NA NA NA hsa-miR-200b-3p PPARGC1A 2.11744072703209 1.66710572104191e-43 -2.61634087589818 7.44821426380706e-32 mirMAP -0.324802263276939 2.39392476805595e-11 NA NA NA hsa-miR-200c-3p PPARGC1A 2.07038651806183 6.84613386286599e-51 -2.61634087589818 7.44821426380706e-32 mirMAP -0.427261934605626 9.16617706269459e-16 NA NA NA hsa-let-7e-5p PPARGC1B 0.261471269338985 0.00191077095550257 -1.46182968985053 1.35672112520709e-22 miRNATAP -0.218533321168113 0.00049476674437201 NA NA NA hsa-miR-141-3p PPARGC1B 2.99777540204168 1.26370498493024e-78 -1.46182968985053 1.35672112520709e-22 mirMAP -0.236237371615472 8.43149296242768e-16 NA NA NA hsa-miR-200a-3p PPARGC1B 2.55218480823434 2.96135446816238e-51 -1.46182968985053 1.35672112520709e-22 mirMAP -0.218993282047533 3.24643157595353e-14 NA NA NA hsa-miR-200b-3p PPARGC1B 2.11744072703209 1.66710572104191e-43 -1.46182968985053 1.35672112520709e-22 mirMAP -0.237691719808896 1.37382489867472e-13 NA NA NA hsa-miR-200c-3p PPARGC1B 2.07038651806183 6.84613386286599e-51 -1.46182968985053 1.35672112520709e-22 mirMAP -0.25650844094968 3.96925424783989e-13 NA NA NA hsa-miR-141-3p PPFIBP1 2.99777540204168 1.26370498493024e-78 -0.738206527263465 1.91555687119124e-17 MirTarget -0.150400762269747 4.55624575032073e-19 NA NA NA hsa-miR-200a-3p PPFIBP1 2.55218480823434 2.96135446816238e-51 -0.738206527263465 1.91555687119124e-17 MirTarget -0.148029609494035 3.47561243575277e-19 NA NA NA hsa-miR-200b-3p PPFIBP1 2.11744072703209 1.66710572104191e-43 -0.738206527263465 1.91555687119124e-17 TargetScan -0.161248814152461 1.96569838965165e-18 NA NA NA hsa-miR-28-5p PPIP5K1 -0.14267073663385 0.0497619246260571 -0.194364800594986 0.0237079880541731 miRanda -0.314004798274111 6.46576353569024e-15 NA NA NA hsa-miR-200b-3p PPM1F 2.11744072703209 1.66710572104191e-43 -1.01782278266201 2.82903184176664e-41 MirTarget;TargetScan -0.141648458560111 1.15401038245452e-17 NA NA NA hsa-miR-200c-3p PPM1F 2.07038651806183 6.84613386286599e-51 -1.01782278266201 2.82903184176664e-41 miRNAWalker2_validate;MirTarget;miRNATAP -0.203540907484171 6.22609794635238e-30 22144583 MicroRNA 200c represses migration and invasion of breast cancer cells by targeting actin regulatory proteins FHOD1 and PPM1F; We identified FHOD1 and PPM1F direct regulators of the actin cytoskeleton as novel targets of miR-200c; Remarkably expression levels of FHOD1 and PPM1F were inversely correlated with the level of miR-200c in breast cancer cell lines breast cancer patient samples and 58 cancer cell lines of various origins breast cancer hsa-miR-141-3p PPM1K 2.99777540204168 1.26370498493024e-78 -0.767862143041894 8.32708135493473e-08 MirTarget -0.117756347106484 2.56336083071318e-05 NA NA NA hsa-miR-141-3p PPM1L 2.99777540204168 1.26370498493024e-78 -1.38023478402259 3.45760320629762e-23 MirTarget;TargetScan -0.192009566295454 2.80072569846837e-12 NA NA NA hsa-miR-200a-3p PPM1L 2.55218480823434 2.96135446816238e-51 -1.38023478402259 3.45760320629762e-23 MirTarget -0.170416821847245 2.89565432139411e-10 NA NA NA hsa-miR-28-5p PPOX -0.14267073663385 0.0497619246260571 0.830291250171679 6.58170304361639e-23 miRanda -0.169004189934174 3.92854986223783e-05 NA NA NA hsa-miR-200b-3p PPP1R12B 2.11744072703209 1.66710572104191e-43 -2.23500813943069 2.60349931631869e-111 TargetScan -0.301718429708338 1.19474770575743e-38 NA NA NA hsa-miR-28-5p PPP1R14D -0.14267073663385 0.0497619246260571 1.08406784337159 4.61757779337715e-07 miRanda;miRNATAP -0.688171627902918 1.5008747175405e-11 NA NA NA hsa-let-7e-5p PPP1R16B 0.261471269338985 0.00191077095550257 -2.17774746201998 4.8680300203316e-39 miRNATAP -0.303310627682202 2.12614120769215e-05 NA NA NA hsa-miR-141-3p PPP1R3G 2.99777540204168 1.26370498493024e-78 -1.0988069165309 3.81547971781581e-15 TargetScan -0.303130547023889 6.51032067161583e-30 NA NA NA hsa-miR-200b-3p PPP2R1B 2.11744072703209 1.66710572104191e-43 -1.24069690315388 3.45729939213988e-47 MirTarget -0.190114683335312 5.20726875191601e-24 NA NA NA hsa-miR-200c-3p PPP2R1B 2.07038651806183 6.84613386286599e-51 -1.24069690315388 3.45729939213988e-47 MirTarget -0.226923946553815 2.68646974148231e-28 21248297 Western blotting showed that knockdown of miR-200c expression was associated with increased expression of PPP2R1B a subunit of protein phosphatase 2A which resulted in reduced expression of phospho-Akt esophageal cancer hsa-miR-141-3p PPP2R2B 2.99777540204168 1.26370498493024e-78 -1.93953123840583 5.78989293907757e-30 TargetScan -0.315881073340513 5.36482191004776e-21 NA NA NA hsa-miR-132-3p PPP2R5E -0.0365213889238607 0.668598301088667 0.018935638230313 0.793647310855766 MirTarget -0.117209424280952 5.86934317627525e-05 NA NA NA hsa-let-7e-5p PRDM1 0.261471269338985 0.00191077095550257 0.21691886383341 0.0416233654687665 miRNATAP -0.10994146112291 0.0116173033640358 NA NA NA hsa-miR-141-3p PRDM16 2.99777540204168 1.26370498493024e-78 -2.10183629954012 7.1878186105897e-40 mirMAP -0.455556653224769 2.57442829348823e-50 NA NA NA hsa-miR-200a-3p PRDM16 2.55218480823434 2.96135446816238e-51 -2.10183629954012 7.1878186105897e-40 mirMAP -0.375067410578859 1.43493425547548e-34 NA NA NA hsa-miR-200b-3p PRDM16 2.11744072703209 1.66710572104191e-43 -2.10183629954012 7.1878186105897e-40 MirTarget;TargetScan -0.385325298950015 2.32734489384361e-29 NA NA NA hsa-miR-200c-3p PRDM16 2.07038651806183 6.84613386286599e-51 -2.10183629954012 7.1878186105897e-40 MirTarget;miRNATAP -0.468792246552993 3.5803904073721e-36 NA NA NA hsa-miR-141-3p PRELP 2.99777540204168 1.26370498493024e-78 -2.43067905735392 8.0375135102859e-39 mirMAP -0.471786585742231 1.40436700415086e-38 NA NA NA hsa-miR-200a-3p PRELP 2.55218480823434 2.96135446816238e-51 -2.43067905735392 8.0375135102859e-39 mirMAP -0.400904112552462 1.1916252266967e-28 NA NA NA hsa-miR-28-5p PREPL -0.14267073663385 0.0497619246260571 -0.322293281183161 8.79993670730062e-06 miRanda -0.11687031971652 0.000735961886475128 NA NA NA hsa-miR-141-3p PRICKLE1 2.99777540204168 1.26370498493024e-78 0.0303646488653939 0.804968550597215 TargetScan -0.110970210955193 3.06180806587071e-06 NA NA NA hsa-miR-132-3p PRICKLE2 -0.0365213889238607 0.668598301088667 -1.41551101306739 1.76700405075257e-30 MirTarget;miRNATAP -0.13545645775625 0.00901118165664025 NA NA NA hsa-miR-141-3p PRKACB 2.99777540204168 1.26370498493024e-78 -0.383846400368397 0.0117591306589187 MirTarget;TargetScan;miRNATAP -0.14986275424127 3.7367241254854e-07 NA NA NA hsa-miR-200b-3p PRKACB 2.11744072703209 1.66710572104191e-43 -0.383846400368397 0.0117591306589187 MirTarget;TargetScan -0.128358992363134 6.97422500356901e-05 NA NA NA hsa-miR-200c-3p PRKACB 2.07038651806183 6.84613386286599e-51 -0.383846400368397 0.0117591306589187 MirTarget;miRNATAP -0.165596646495394 2.94921644943646e-06 NA NA NA hsa-miR-200b-3p PRKAR2B 2.11744072703209 1.66710572104191e-43 -2.21081590198765 1.60222507436243e-42 TargetScan -0.280997010338504 3.04124526480141e-15 NA NA NA hsa-miR-200c-3p PRKAR2B 2.07038651806183 6.84613386286599e-51 -2.21081590198765 1.60222507436243e-42 miRNATAP -0.292941274401131 8.32765818000856e-14 NA NA NA hsa-miR-200b-3p PRKCA 2.11744072703209 1.66710572104191e-43 -1.70723657875247 1.7688165305473e-34 TargetScan -0.338107140907763 7.43601898887161e-30 NA NA NA hsa-miR-200c-3p PRKCA 2.07038651806183 6.84613386286599e-51 -1.70723657875247 1.7688165305473e-34 miRNATAP -0.384868851727468 4.79014422420278e-32 NA NA NA hsa-miR-200b-3p PRKCB 2.11744072703209 1.66710572104191e-43 -0.447147877250759 0.0168049140120418 MirTarget -0.185811618752792 2.61023291805883e-06 NA NA NA hsa-miR-200c-3p PRKCB 2.07038651806183 6.84613386286599e-51 -0.447147877250759 0.0168049140120418 MirTarget;miRNATAP -0.190171510726694 1.24294313881003e-05 NA NA NA hsa-miR-141-3p PRKCE 2.99777540204168 1.26370498493024e-78 -0.665119336429135 4.20185755136611e-11 TargetScan;miRNATAP -0.126161525544588 1.2962263510062e-10 NA NA NA hsa-miR-141-3p PRKD1 2.99777540204168 1.26370498493024e-78 -1.79496662198383 1.13842611279171e-44 MirTarget;TargetScan -0.406292393970467 1.52337242004486e-62 NA NA NA hsa-miR-200a-3p PRKD1 2.55218480823434 2.96135446816238e-51 -1.79496662198383 1.13842611279171e-44 MirTarget -0.349454946030932 1.34010425652452e-46 NA NA NA hsa-miR-200b-3p PRKG1 2.11744072703209 1.66710572104191e-43 -1.38365839435521 1.52547149627446e-11 TargetScan -0.353809684521588 3.10054322182671e-16 NA NA NA hsa-miR-200c-3p PRKG1 2.07038651806183 6.84613386286599e-51 -1.38365839435521 1.52547149627446e-11 miRNATAP -0.393121784158909 1.48074207227863e-16 NA NA NA hsa-miR-28-5p PROM2 -0.14267073663385 0.0497619246260571 1.56071419150459 1.77985184998625e-25 miRanda -0.346665083892436 2.17099288160034e-06 NA NA NA hsa-miR-200b-3p PROX1 2.11744072703209 1.66710572104191e-43 -3.30249132498998 3.55828560245591e-41 TargetScan -0.483046219226898 2.46808862172114e-19 NA NA NA hsa-miR-143-3p PRPF19 -1.23248181631499 4.74160976678504e-28 0.768251398860957 6.86438313746285e-40 miRNATAP -0.15792641480204 3.74963393938871e-19 NA NA NA hsa-miR-28-5p PRR5-ARHGAP8 -0.14267073663385 0.0497619246260571 1.48757303661783 5.00986879889586e-23 miRanda -0.204597767552065 0.00551521866120443 NA NA NA hsa-miR-141-3p PRTG 2.99777540204168 1.26370498493024e-78 -1.2107463479419 1.82371391116989e-11 MirTarget;miRNATAP -0.292350893088517 4.6146675982696e-17 NA NA NA hsa-miR-200a-3p PRTG 2.55218480823434 2.96135446816238e-51 -1.2107463479419 1.82371391116989e-11 MirTarget;miRNATAP -0.282738044631308 1.32311244906525e-16 NA NA NA hsa-miR-200c-3p PRTG 2.07038651806183 6.84613386286599e-51 -1.2107463479419 1.82371391116989e-11 miRNATAP -0.293129535070471 3.14708792150803e-12 NA NA NA hsa-miR-28-5p PRTG -0.14267073663385 0.0497619246260571 -1.2107463479419 1.82371391116989e-11 miRNATAP -0.392850568238467 5.69464187735237e-06 NA NA NA hsa-miR-200b-3p PSAT1 2.11744072703209 1.66710572104191e-43 -1.10795238445819 2.31514055686743e-05 MirTarget;TargetScan -0.245468915718648 1.01063670576654e-05 NA NA NA hsa-miR-200c-3p PSAT1 2.07038651806183 6.84613386286599e-51 -1.10795238445819 2.31514055686743e-05 MirTarget -0.182682310425925 0.00289612417839974 NA NA NA hsa-miR-143-3p PSME4 -1.23248181631499 4.74160976678504e-28 0.337884927693191 2.61253739828762e-05 miRNATAP -0.101186765140396 2.09437784036223e-05 NA NA NA hsa-let-7e-5p PTAFR 0.261471269338985 0.00191077095550257 -0.419826897998891 0.00376684536061041 miRNATAP -0.154644370651839 0.0092134617974909 NA NA NA hsa-miR-141-3p PTCH1 2.99777540204168 1.26370498493024e-78 -1.99144733451091 8.8131310666777e-41 TargetScan;miRNATAP -0.259642531273444 3.49181018900683e-18 NA NA NA hsa-miR-200a-3p PTCH1 2.55218480823434 2.96135446816238e-51 -1.99144733451091 8.8131310666777e-41 miRNATAP -0.234599971595617 1.47282799732142e-15 NA NA NA hsa-miR-200b-3p PTCH1 2.11744072703209 1.66710572104191e-43 -1.99144733451091 8.8131310666777e-41 TargetScan -0.239031658469218 3.16803727762646e-13 NA NA NA hsa-miR-141-3p PTCHD1 2.99777540204168 1.26370498493024e-78 -3.92879851720895 4.87722585188742e-36 mirMAP -0.417489936928319 3.61072935593697e-11 NA NA NA hsa-miR-200a-3p PTCHD1 2.55218480823434 2.96135446816238e-51 -3.92879851720895 4.87722585188742e-36 mirMAP -0.385118778435802 5.16061869468264e-10 NA NA NA hsa-miR-141-3p PTCHD3 2.99777540204168 1.26370498493024e-78 -3.42394320451458 1.59157910515074e-31 TargetScan -0.480132158758225 1.61981125202704e-16 NA NA NA hsa-miR-200b-3p PTCHD3 2.11744072703209 1.66710572104191e-43 -3.42394320451458 1.59157910515074e-31 TargetScan -0.399761803900086 4.39001630281016e-10 NA NA NA hsa-miR-132-3p PTEN -0.0365213889238607 0.668598301088667 -0.737945156702629 1.26474514880987e-22 miRNATAP -0.136713479453887 1.19438197426319e-05 NA NA NA hsa-miR-141-3p PTEN 2.99777540204168 1.26370498493024e-78 -0.737945156702629 1.26474514880987e-22 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.12717832397844 6.47904977288109e-18 27644195;24742567 Involvement of microRNA 141 3p in 5 fluorouracil and oxaliplatin chemo resistance in esophageal cancer cells via regulation of PTEN; Western blot exhibited altered protein levels of PTEN Akt and PI3k with miR-141-3p inhibitor; An inverse correlation between PTEN expression and miR-141-3p expression was also observed in tissue samples; Our study demonstrated that miR-141-3p contributed to an acquired chemo-resistance through PTEN modulation both in vitro and in vivo;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis drug resistance;tumorigenesis esophageal cancer;endometrial cancer hsa-miR-200a-3p PTEN 2.55218480823434 2.96135446816238e-51 -0.737945156702629 1.26474514880987e-22 miRNATAP -0.109411985169924 5.36101217094024e-14 22637745;24742567;21408027 Re expression of miR 200 by novel approaches regulates the expression of PTEN and MT1 MMP in pancreatic cancer; We initially compared the expression profile of miR-200 family PTEN and MT1-MMP expression in six pancreatic cancer PC cell lines by qRT-PCR and western blot analysis; We found loss of expression of miR-200a b and c in chemo-resistant PC cell lines which was correlated with loss of PTEN and over-expression of MT1-MMP; The expression of miR-200 family and PTEN was significantly re-expressed whereas the expression of MT1-MMP was down-regulated by CDF and BR-DIM treatment; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants ;tumorigenesis; pancreatic cancer;endometrial cancer;pancreatic cancer hsa-miR-200b-3p PTEN 2.11744072703209 1.66710572104191e-43 -0.737945156702629 1.26474514880987e-22 TargetScan;mirMAP -0.130827329200595 5.08867014435072e-16 22637745;21408027 Re expression of miR 200 by novel approaches regulates the expression of PTEN and MT1 MMP in pancreatic cancer; We initially compared the expression profile of miR-200 family PTEN and MT1-MMP expression in six pancreatic cancer PC cell lines by qRT-PCR and western blot analysis; The expression of miR-200 family and PTEN was significantly re-expressed whereas the expression of MT1-MMP was down-regulated by CDF and BR-DIM treatment; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants ; pancreatic cancer;pancreatic cancer hsa-miR-200c-3p PTEN 2.07038651806183 6.84613386286599e-51 -0.737945156702629 1.26474514880987e-22 mirMAP;miRNATAP -0.143190372668334 7.03511808200308e-16 24682933;22637745 In conclusion miR-200c functions as an oncogene in colon cancer cells through regulating tumor cell apoptosis survival invasion and metastasis as well as xenograft tumor growth through inhibition of PTEN expression and p53 phosphorylation;Forced over-expression or silencing of miR-200c followed by either CDF or BR-DIM treatment of MIAPaCa-2 cells altered the morphology of cells wound-healing capacity colony formation and the expression of MT1-MMP and PTEN; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment metastasis;poor survival; colon cancer;pancreatic cancer hsa-miR-28-5p PTER -0.14267073663385 0.0497619246260571 -0.191994453096763 0.0246991311855573 miRanda -0.133337486918225 0.00104206341060228 NA NA NA hsa-miR-200b-3p PTGDR 2.11744072703209 1.66710572104191e-43 -1.45601735106844 5.15780746632607e-19 TargetScan -0.306411093360221 1.12408198064579e-18 NA NA NA hsa-miR-28-5p PTGER3 -0.14267073663385 0.0497619246260571 -2.08536199219359 1.19288336263977e-20 miRanda -0.536055938428695 8.25873008564214e-07 NA NA NA hsa-miR-200b-3p PTHLH 2.11744072703209 1.66710572104191e-43 -1.44742776852114 2.01207752809059e-10 MirTarget;TargetScan -0.160626397844438 0.000990186901529906 NA NA NA hsa-miR-200c-3p PTHLH 2.07038651806183 6.84613386286599e-51 -1.44742776852114 2.01207752809059e-10 MirTarget -0.21000719036726 8.82486626068071e-05 NA NA NA hsa-miR-28-5p PTP4A2 -0.14267073663385 0.0497619246260571 0.38574449513147 1.13328117872512e-06 miRanda -0.227965984611241 1.35730245928027e-09 NA NA NA hsa-miR-200b-3p PTPN11 2.11744072703209 1.66710572104191e-43 -0.73371833861962 7.24333657010257e-22 TargetScan -0.131913631045747 6.43155343439281e-16 NA NA NA hsa-miR-200c-3p PTPN11 2.07038651806183 6.84613386286599e-51 -0.73371833861962 7.24333657010257e-22 miRNATAP -0.109200606157251 1.61966841065561e-09 NA NA NA hsa-miR-200b-3p PTPN13 2.11744072703209 1.66710572104191e-43 -0.809960140594897 7.91282502499025e-08 TargetScan -0.173793950896567 5.80741713962217e-08 NA NA NA hsa-miR-200c-3p PTPN13 2.07038651806183 6.84613386286599e-51 -0.809960140594897 7.91282502499025e-08 miRNAWalker2_validate;miRTarBase -0.18590883585444 1.33149075961008e-07 NA NA NA hsa-miR-200b-3p PTPN14 2.11744072703209 1.66710572104191e-43 -1.86383552012172 8.31373613084314e-42 MirTarget;TargetScan -0.214736349959927 1.54418322506977e-12 NA NA NA hsa-miR-200c-3p PTPN14 2.07038651806183 6.84613386286599e-51 -1.86383552012172 8.31373613084314e-42 MirTarget -0.274273570115621 1.50306938607158e-16 NA NA NA hsa-miR-200b-3p PTPN21 2.11744072703209 1.66710572104191e-43 -1.65383053269161 3.3398027285675e-48 TargetScan -0.258284554743192 2.14008560718297e-25 NA NA NA hsa-miR-200c-3p PTPN21 2.07038651806183 6.84613386286599e-51 -1.65383053269161 3.3398027285675e-48 miRNATAP -0.365419761984016 9.07989896626038e-43 NA NA NA hsa-miR-141-3p PTPRD 2.99777540204168 1.26370498493024e-78 0.150114854210014 0.427806011089459 miRNAWalker2_validate;TargetScan;miRNATAP -0.252890035581267 3.43971076968601e-12 NA NA NA hsa-miR-200a-3p PTPRD 2.55218480823434 2.96135446816238e-51 0.150114854210014 0.427806011089459 miRNAWalker2_validate;miRNATAP -0.264438339347084 1.0759495244519e-13 NA NA NA hsa-miR-200b-3p PTPRD 2.11744072703209 1.66710572104191e-43 0.150114854210014 0.427806011089459 miRNAWalker2_validate -0.30522980195377 1.14494479230952e-14 NA NA NA hsa-miR-200c-3p PTPRD 2.07038651806183 6.84613386286599e-51 0.150114854210014 0.427806011089459 miRNAWalker2_validate -0.341096545199508 4.09077043221735e-15 NA NA NA hsa-miR-141-3p PTPRG 2.99777540204168 1.26370498493024e-78 -1.29644517088256 8.3671572754937e-21 MirTarget;TargetScan;miRNATAP -0.333940878967987 1.24675139386592e-36 NA NA NA hsa-miR-200a-3p PTPRG 2.55218480823434 2.96135446816238e-51 -1.29644517088256 8.3671572754937e-21 MirTarget;miRNATAP -0.28345921779417 3.35874915203545e-27 NA NA NA hsa-miR-132-3p PTPRT -0.0365213889238607 0.668598301088667 -0.922018035462999 0.0136915437550837 mirMAP -0.47728288443448 0.00163655064188061 NA NA NA hsa-miR-200b-3p PTPRZ1 2.11744072703209 1.66710572104191e-43 -4.20756137566181 6.32393300486789e-30 MirTarget -0.290948027136067 0.000350497055176143 NA NA NA hsa-miR-200c-3p PTPRZ1 2.07038651806183 6.84613386286599e-51 -4.20756137566181 6.32393300486789e-30 MirTarget;miRNATAP -0.508617189702044 1.08811052740162e-08 NA NA NA hsa-miR-28-5p PUS7L -0.14267073663385 0.0497619246260571 0.145113950566918 0.0897960737939671 miRanda -0.114959118446961 0.00473506724081946 NA NA NA hsa-miR-28-5p PWWP2B -0.14267073663385 0.0497619246260571 1.03031841179004 7.74703277608747e-23 mirMAP -0.265082119768918 1.97291079473607e-07 NA NA NA hsa-miR-141-3p PXK 2.99777540204168 1.26370498493024e-78 -0.593312260816982 1.83895419398506e-09 MirTarget;TargetScan -0.152506649644455 1.16365951879434e-15 NA NA NA hsa-miR-200a-3p PXK 2.55218480823434 2.96135446816238e-51 -0.593312260816982 1.83895419398506e-09 MirTarget -0.133003624826933 1.34262930229881e-12 NA NA NA hsa-miR-28-5p PXMP4 -0.14267073663385 0.0497619246260571 -0.282574272380821 0.0474092478424069 miRNATAP -0.352401022452475 1.79243680180962e-07 NA NA NA hsa-miR-28-5p PYCRL -0.14267073663385 0.0497619246260571 1.82468595902489 2.66248549409042e-58 miRanda -0.22504000152473 0.000103907331598124 NA NA NA hsa-miR-200b-3p PYGO1 2.11744072703209 1.66710572104191e-43 -1.89478551615963 1.39585960146891e-22 mirMAP -0.389994931400337 3.17627670880994e-21 NA NA NA hsa-miR-200c-3p PYGO1 2.07038651806183 6.84613386286599e-51 -1.89478551615963 1.39585960146891e-22 mirMAP -0.377790343694091 1.22974201087685e-16 NA NA NA hsa-miR-141-3p QKI 2.99777540204168 1.26370498493024e-78 -1.32659632374889 1.06640742607879e-48 TargetScan -0.263244011547577 6.74334706147368e-51 NA NA NA hsa-miR-200b-3p QKI 2.11744072703209 1.66710572104191e-43 -1.32659632374889 1.06640742607879e-48 TargetScan -0.27656462658597 7.84044727568241e-47 NA NA NA hsa-miR-28-5p QSOX1 -0.14267073663385 0.0497619246260571 0.60255748274154 3.62670004110163e-08 miRanda -0.152628390389117 0.00364426402193613 NA NA NA hsa-miR-143-3p RAB11FIP1 -1.23248181631499 4.74160976678504e-28 0.69116808896398 6.48076941128492e-06 MirTarget -0.171574943477004 0.000162586906206592 NA NA NA hsa-miR-28-5p RAB11FIP1 -0.14267073663385 0.0497619246260571 0.69116808896398 6.48076941128492e-06 miRanda -0.338905684912959 3.5216293612899e-06 NA NA NA hsa-miR-141-3p RAB11FIP2 2.99777540204168 1.26370498493024e-78 -0.940510639961515 7.61132098193432e-42 MirTarget -0.153668996619729 3.81056557287882e-29 NA NA NA hsa-miR-200a-3p RAB11FIP2 2.55218480823434 2.96135446816238e-51 -0.940510639961515 7.61132098193432e-42 MirTarget -0.145235347794193 5.04463877491733e-27 NA NA NA hsa-miR-200b-3p RAB11FIP2 2.11744072703209 1.66710572104191e-43 -0.940510639961515 7.61132098193432e-42 MirTarget;TargetScan -0.154694324874895 8.80637401715132e-25 NA NA NA hsa-miR-200c-3p RAB11FIP2 2.07038651806183 6.84613386286599e-51 -0.940510639961515 7.61132098193432e-42 MirTarget;miRNATAP -0.168205426171744 3.11114089610281e-24 NA NA NA hsa-miR-143-3p RAB11FIP4 -1.23248181631499 4.74160976678504e-28 1.53441164799704 3.50928776989217e-42 MirTarget -0.27095729924281 4.96807287253314e-15 NA NA NA hsa-miR-145-5p RAB11FIP4 -2.62703571936687 7.64402900188551e-88 1.53441164799704 3.50928776989217e-42 MirTarget -0.307953995505967 5.50103778404683e-31 NA NA NA hsa-miR-28-5p RAB14 -0.14267073663385 0.0497619246260571 -0.0753658943653273 0.14399081719528 miRanda;miRNATAP -0.104162677236291 1.96703121287158e-05 NA NA NA hsa-miR-28-5p RAB1B -0.14267073663385 0.0497619246260571 0.574336352661568 1.96529572629854e-18 mirMAP -0.221555987426019 1.9009866654715e-12 NA NA NA hsa-miR-200b-3p RAB23 2.11744072703209 1.66710572104191e-43 0.076671251457137 0.39594420106942 TargetScan -0.103715807740545 4.84000345070298e-08 NA NA NA hsa-miR-28-5p RAB24 -0.14267073663385 0.0497619246260571 0.303475540325776 0.000592601062267745 miRanda -0.161893953740376 0.000118862111928195 NA NA NA hsa-miR-28-5p RAB30 -0.14267073663385 0.0497619246260571 -0.478979836326187 0.00389471393081148 miRanda -0.459147966639985 5.06933876170286e-09 NA NA NA hsa-miR-28-5p RAB31 -0.14267073663385 0.0497619246260571 1.21770647114932 2.0308057149131e-20 miRanda -0.203782492807051 0.00148128168670373 NA NA NA hsa-miR-141-3p RAB3C 2.99777540204168 1.26370498493024e-78 -2.54624635924093 4.17710497877998e-25 mirMAP -0.519206437285959 1.52328825828455e-27 NA NA NA hsa-miR-200a-3p RAB3C 2.55218480823434 2.96135446816238e-51 -2.54624635924093 4.17710497877998e-25 mirMAP -0.384698813583737 6.09458879874517e-16 NA NA NA hsa-miR-141-3p RAB8B 2.99777540204168 1.26370498493024e-78 -0.735083061711054 5.77801459708655e-22 MirTarget -0.175711365588715 2.66665848868704e-33 NA NA NA hsa-miR-200a-3p RAB8B 2.55218480823434 2.96135446816238e-51 -0.735083061711054 5.77801459708655e-22 MirTarget -0.150397339738036 3.09646179132943e-25 NA NA NA hsa-miR-200b-3p RAB8B 2.11744072703209 1.66710572104191e-43 -0.735083061711054 5.77801459708655e-22 TargetScan;mirMAP -0.170309156827483 3.69181942005047e-26 NA NA NA hsa-miR-200c-3p RAB8B 2.07038651806183 6.84613386286599e-51 -0.735083061711054 5.77801459708655e-22 mirMAP;miRNATAP -0.197937237799856 2.97827516188044e-29 NA NA NA hsa-miR-143-3p RABEP1 -1.23248181631499 4.74160976678504e-28 -0.210962848317383 0.0452838127956761 MirTarget -0.124053203806078 6.65254551724371e-05 NA NA NA hsa-miR-132-3p RAD50 -0.0365213889238607 0.668598301088667 -0.135555077373277 0.0888619388234284 MirTarget -0.104046844677219 0.00123130645344954 NA NA NA hsa-miR-141-3p RAD54L2 2.99777540204168 1.26370498493024e-78 -0.957945852257672 1.5527860874268e-11 TargetScan -0.135848834638527 1.05295111710358e-06 NA NA NA hsa-miR-141-3p RAG1 2.99777540204168 1.26370498493024e-78 -1.39090074941032 2.39566741675824e-25 TargetScan -0.221347757180805 3.95274659637967e-17 NA NA NA hsa-miR-200b-3p RAG1 2.11744072703209 1.66710572104191e-43 -1.39090074941032 2.39566741675824e-25 MirTarget -0.168266344426961 6.6970077945692e-09 NA NA NA hsa-miR-200c-3p RAG1 2.07038651806183 6.84613386286599e-51 -1.39090074941032 2.39566741675824e-25 MirTarget -0.220512181672642 3.92886762076485e-12 NA NA NA hsa-miR-28-5p RALGAPB -0.14267073663385 0.0497619246260571 0.114339916324857 0.110018355395065 miRanda -0.136336527884099 5.88496299374839e-05 NA NA NA hsa-miR-143-3p RALGPS1 -1.23248181631499 4.74160976678504e-28 0.320371955401898 0.000743623076739109 mirMAP -0.163029425065667 5.38690410004569e-09 NA NA NA hsa-miR-28-5p RAP1GDS1 -0.14267073663385 0.0497619246260571 0.478268842738917 4.89838888082789e-09 miRanda -0.179884587821433 4.21195745918722e-06 NA NA NA hsa-miR-200b-3p RAPGEF1 2.11744072703209 1.66710572104191e-43 -0.577309067105408 2.14055895898889e-26 TargetScan -0.115991922575951 9.13877211713485e-24 NA NA NA hsa-miR-141-3p RAPGEF2 2.99777540204168 1.26370498493024e-78 -1.07954431946973 1.09869317643974e-45 MirTarget;TargetScan;miRNATAP -0.190427522928983 4.04692361635089e-37 NA NA NA hsa-miR-200a-3p RAPGEF2 2.55218480823434 2.96135446816238e-51 -1.07954431946973 1.09869317643974e-45 MirTarget;miRNATAP -0.167119036962075 1.78754985294303e-29 NA NA NA hsa-miR-200b-3p RAPGEF2 2.11744072703209 1.66710572104191e-43 -1.07954431946973 1.09869317643974e-45 MirTarget;TargetScan -0.179237551056118 2.21593713134509e-27 NA NA NA hsa-miR-200c-3p RAPGEF2 2.07038651806183 6.84613386286599e-51 -1.07954431946973 1.09869317643974e-45 MirTarget;miRNATAP -0.202553658903887 6.1626718024825e-29 NA NA NA hsa-miR-28-5p RAPGEFL1 -0.14267073663385 0.0497619246260571 0.740048213907199 1.05350561263932e-05 miRanda -0.284270875346076 0.000399239787482548 NA NA NA hsa-miR-141-3p RARB 2.99777540204168 1.26370498493024e-78 -1.28928084445976 3.54851642399018e-22 TargetScan;miRNATAP -0.152445904660738 7.47123153584678e-09 NA NA NA hsa-miR-200a-3p RARB 2.55218480823434 2.96135446816238e-51 -1.28928084445976 3.54851642399018e-22 miRNATAP -0.105743334819733 4.77795115323628e-05 NA NA NA hsa-miR-141-3p RASA2 2.99777540204168 1.26370498493024e-78 -0.987338236523419 4.85695047036301e-10 TargetScan -0.114558440879572 0.000231326184807738 NA NA NA hsa-miR-200b-3p RASA2 2.11744072703209 1.66710572104191e-43 -0.987338236523419 4.85695047036301e-10 TargetScan -0.116042713824606 0.000635084861671019 NA NA NA hsa-miR-141-3p RASA4 2.99777540204168 1.26370498493024e-78 -0.759819487285073 1.42668565311618e-13 mirMAP -0.161911829090065 4.4653227116395e-16 NA NA NA hsa-miR-200a-3p RASA4 2.55218480823434 2.96135446816238e-51 -0.759819487285073 1.42668565311618e-13 mirMAP -0.113592876991353 8.69071762139026e-09 NA NA NA hsa-miR-200c-3p RASAL2 2.07038651806183 6.84613386286599e-51 -0.566349890853123 1.84617719047055e-11 mirMAP -0.113399606662439 9.2548700645001e-09 NA NA NA hsa-miR-200b-3p RASGEF1B 2.11744072703209 1.66710572104191e-43 -1.24434781637468 2.49466982652341e-23 mirMAP -0.173110614504983 1.45918717867934e-10 NA NA NA hsa-miR-132-3p RASGRF2 -0.0365213889238607 0.668598301088667 -1.50231288432749 1.31976412389238e-25 mirMAP -0.320540348787789 7.60624790957772e-08 NA NA NA hsa-miR-28-5p RASGRP4 -0.14267073663385 0.0497619246260571 -0.655281786974586 6.53684341783125e-09 miRanda -0.1170558792494 0.0311401193861443 NA NA NA hsa-miR-141-3p RASSF2 2.99777540204168 1.26370498493024e-78 -0.0757663600101672 0.471968773241686 miRNAWalker2_validate -0.135873264046898 1.85145668024501e-11 NA NA NA hsa-miR-200a-3p RASSF2 2.55218480823434 2.96135446816238e-51 -0.0757663600101672 0.471968773241686 miRNAWalker2_validate -0.122092807456322 8.31045841692893e-10 NA NA NA hsa-miR-200b-3p RASSF2 2.11744072703209 1.66710572104191e-43 -0.0757663600101672 0.471968773241686 miRNAWalker2_validate -0.132962009202936 1.87793486378845e-09 NA NA NA hsa-miR-200c-3p RASSF2 2.07038651806183 6.84613386286599e-51 -0.0757663600101672 0.471968773241686 miRNAWalker2_validate -0.15915180997094 5.64117330111008e-11 NA NA NA hsa-miR-141-3p RASSF8 2.99777540204168 1.26370498493024e-78 -1.0150883507772 8.73226382591887e-14 TargetScan -0.192508382074018 3.83103579263277e-13 NA NA NA hsa-miR-200b-3p RASSF8 2.11744072703209 1.66710572104191e-43 -1.0150883507772 8.73226382591887e-14 TargetScan -0.184036405558272 2.3235209242109e-10 NA NA NA hsa-miR-200c-3p RASSF8 2.07038651806183 6.84613386286599e-51 -1.0150883507772 8.73226382591887e-14 miRNATAP -0.1890325037856 3.39391770795434e-09 NA NA NA hsa-miR-141-3p RBM20 2.99777540204168 1.26370498493024e-78 -1.04515069057265 1.01196665241559e-06 TargetScan -0.16345447334023 8.95290713776299e-05 NA NA NA hsa-miR-200b-3p RBM20 2.11744072703209 1.66710572104191e-43 -1.04515069057265 1.01196665241559e-06 MirTarget;TargetScan -0.150142477675714 0.000990554418747619 NA NA NA hsa-miR-200c-3p RBM20 2.07038651806183 6.84613386286599e-51 -1.04515069057265 1.01196665241559e-06 MirTarget -0.206131312038423 3.80541476757091e-05 NA NA NA hsa-miR-141-3p RBM24 2.99777540204168 1.26370498493024e-78 -0.541667628704172 0.0692752095429657 TargetScan -0.137297704759525 0.0179697400157415 NA NA NA hsa-miR-28-5p RBM47 -0.14267073663385 0.0497619246260571 0.732126183413737 2.07916919204205e-13 miRanda -0.336368008731163 1.55575789347527e-12 NA NA NA hsa-miR-28-5p RBM5 -0.14267073663385 0.0497619246260571 -0.402544753547652 4.49201522260434e-13 miRanda -0.117173839370532 1.14468263555622e-05 NA NA NA hsa-miR-141-3p RBM7 2.99777540204168 1.26370498493024e-78 -0.767424967277282 2.65334420291825e-24 MirTarget;TargetScan;miRNATAP -0.127521563165136 6.62209385971035e-18 NA NA NA hsa-miR-200a-3p RBM7 2.55218480823434 2.96135446816238e-51 -0.767424967277282 2.65334420291825e-24 MirTarget;miRNATAP -0.105220098862972 5.88235418010415e-13 NA NA NA hsa-let-7e-5p RBMS1 0.261471269338985 0.00191077095550257 -1.10714556910667 3.80866209473109e-33 miRNATAP -0.151233852990177 0.000115625051738409 NA NA NA hsa-miR-141-3p RBMS1 2.99777540204168 1.26370498493024e-78 -1.10714556910667 3.80866209473109e-33 TargetScan;miRNATAP -0.21805819822546 5.13405207364821e-34 NA NA NA hsa-miR-200a-3p RBMS1 2.55218480823434 2.96135446816238e-51 -1.10714556910667 3.80866209473109e-33 miRNATAP -0.202929363327035 1.65635665551302e-30 NA NA NA hsa-miR-200b-3p RBPJ 2.11744072703209 1.66710572104191e-43 -0.571459795835992 3.29001860179327e-24 mirMAP -0.107010469526237 5.01921033029508e-19 NA NA NA hsa-miR-200c-3p RBPJ 2.07038651806183 6.84613386286599e-51 -0.571459795835992 3.29001860179327e-24 mirMAP -0.111669221035834 3.26109227120596e-17 NA NA NA hsa-miR-132-3p RC3H1 -0.0365213889238607 0.668598301088667 -0.372311986966581 3.40216479930171e-10 mirMAP -0.10432246722457 1.53778825812217e-05 NA NA NA hsa-miR-200b-3p RC3H2 2.11744072703209 1.66710572104191e-43 -0.61834807347816 5.44570104079728e-08 mirMAP -0.129617960026112 8.08181996594934e-08 NA NA NA hsa-miR-200c-3p RC3H2 2.07038651806183 6.84613386286599e-51 -0.61834807347816 5.44570104079728e-08 mirMAP -0.101924113480864 0.000133105502626976 NA NA NA hsa-let-7e-5p RDH10 0.261471269338985 0.00191077095550257 -0.137764097171434 0.406544664462247 miRNATAP -0.200454054546089 0.0031262751214683 NA NA NA hsa-let-7e-5p RDX 0.261471269338985 0.00191077095550257 -0.777241607854884 9.59924790525334e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.122623435373547 0.00232117136821428 NA NA NA hsa-miR-200b-3p RECK 2.11744072703209 1.66710572104191e-43 -1.97765597525965 6.86857718929118e-55 TargetScan -0.404451670676086 1.75438865191091e-50 NA NA NA hsa-miR-200c-3p RECK 2.07038651806183 6.84613386286599e-51 -1.97765597525965 6.86857718929118e-55 miRNATAP -0.482693977896726 1.13593688800954e-60 27574450;24647918 MiR 200c promotes bladder cancer cell migration and invasion by directly targeting RECK; The luciferase reporter assay showed that RECK was a direct target of miR-200c;Finally we demonstrated that expression of miR-200c in H460 cells suppressed cell growth by targeting RECK followed by activation of the JNK signaling pathway and ER stress; Collectively these data show that miR-200c expression sensitizes H460 cells to RESV and this is likely due to RECK expression cell migration; bladder cancer;lung cancer hsa-miR-145-5p REEP1 -2.62703571936687 7.64402900188551e-88 0.546339756833729 0.0100889448892189 MirTarget -0.13001848885332 0.00849903489836659 NA NA NA hsa-miR-28-5p REEP1 -0.14267073663385 0.0497619246260571 0.546339756833729 0.0100889448892189 miRanda -0.801186934216671 8.69273047648115e-16 NA NA NA hsa-miR-200b-3p RELN 2.11744072703209 1.66710572104191e-43 -4.67087443281158 1.50848083381937e-55 MirTarget;TargetScan -0.657437580196194 1.99168662140682e-23 NA NA NA hsa-miR-200c-3p RELN 2.07038651806183 6.84613386286599e-51 -4.67087443281158 1.50848083381937e-55 MirTarget -0.830139052765864 6.0952837560973e-31 NA NA NA hsa-miR-141-3p RFTN1 2.99777540204168 1.26370498493024e-78 -0.774029173591961 3.1218096841595e-14 MirTarget -0.269587408122593 1.48591241297219e-45 NA NA NA hsa-miR-200a-3p RFTN1 2.55218480823434 2.96135446816238e-51 -0.774029173591961 3.1218096841595e-14 MirTarget -0.225218984477146 1.97817456374995e-32 NA NA NA hsa-miR-200b-3p RFTN2 2.11744072703209 1.66710572104191e-43 -1.49900660141076 1.2863678959407e-37 MirTarget -0.365173933563426 1.38592923875734e-50 NA NA NA hsa-miR-200c-3p RFTN2 2.07038651806183 6.84613386286599e-51 -1.49900660141076 1.2863678959407e-37 MirTarget -0.450382599077655 1.38997568689061e-65 NA NA NA hsa-miR-141-3p RGAG1 2.99777540204168 1.26370498493024e-78 -0.770611426630889 1.84724689177991e-05 TargetScan -0.219823292822217 2.70459415665334e-10 NA NA NA hsa-miR-200b-3p RGL1 2.11744072703209 1.66710572104191e-43 -1.67022879602185 1.06541172741944e-55 MirTarget;TargetScan -0.323125969624857 2.26307711509585e-45 NA NA NA hsa-miR-200c-3p RGL1 2.07038651806183 6.84613386286599e-51 -1.67022879602185 1.06541172741944e-55 MirTarget;miRNATAP -0.366117487037179 1.97365894301561e-48 NA NA NA hsa-miR-141-3p RGS7BP 2.99777540204168 1.26370498493024e-78 -3.08832484723279 1.36129686977447e-41 TargetScan;miRNATAP -0.526828492924082 1.566674089427e-31 NA NA NA hsa-miR-200a-3p RGS7BP 2.55218480823434 2.96135446816238e-51 -3.08832484723279 1.36129686977447e-41 miRNATAP -0.442831721651278 4.23883264781572e-23 NA NA NA hsa-miR-28-5p RHOBTB2 -0.14267073663385 0.0497619246260571 -0.153829701163943 0.0709958502726741 mirMAP -0.203530276287614 4.51140200441096e-07 NA NA NA hsa-miR-28-5p RHOT1 -0.14267073663385 0.0497619246260571 -0.270568764875986 8.26985055768295e-05 miRanda -0.107030886738767 0.00109224356536059 NA NA NA hsa-miR-141-3p RIMBP2 2.99777540204168 1.26370498493024e-78 -2.66086302484182 1.10626009172396e-31 mirMAP -0.497128596846083 4.02879899288475e-29 NA NA NA hsa-miR-200a-3p RIMBP2 2.55218480823434 2.96135446816238e-51 -2.66086302484182 1.10626009172396e-31 mirMAP -0.424239841228376 4.81108335516607e-22 NA NA NA hsa-miR-200b-3p RIMKLB 2.11744072703209 1.66710572104191e-43 -0.826556118490011 4.58785373746228e-25 MirTarget;TargetScan -0.124605782720432 4.76653153226331e-13 NA NA NA hsa-miR-200a-3p RIMS1 2.55218480823434 2.96135446816238e-51 -0.116643787448406 0.690079336554856 MirTarget -0.12601082422311 0.0239415058767093 NA NA NA hsa-miR-141-3p RIMS3 2.99777540204168 1.26370498493024e-78 -1.82635174452916 4.12617185172086e-37 mirMAP -0.196008779545818 1.15086723746033e-11 NA NA NA hsa-miR-200a-3p RIMS3 2.55218480823434 2.96135446816238e-51 -1.82635174452916 4.12617185172086e-37 mirMAP -0.147132525285807 2.43452935051596e-07 NA NA NA hsa-miR-200b-3p RIMS3 2.11744072703209 1.66710572104191e-43 -1.82635174452916 4.12617185172086e-37 TargetScan -0.127360290157873 6.19043103475256e-05 NA NA NA hsa-miR-205-5p RIMS4 -1.70057043266505 1.20976599540743e-09 1.93936813754878 1.60005847788467e-09 mirMAP -0.213232264757329 4.8320239511824e-08 NA NA NA hsa-miR-28-5p RIMS4 -0.14267073663385 0.0497619246260571 1.93936813754878 1.60005847788467e-09 miRanda -1.19551474512527 4.05189387001245e-15 NA NA NA hsa-miR-200c-3p RIN2 2.07038651806183 6.84613386286599e-51 -0.13319809102269 0.125216128478784 miRNAWalker2_validate -0.107502630238496 9.09693498682217e-08 NA NA NA hsa-miR-132-3p RIT1 -0.0365213889238607 0.668598301088667 0.255079650622385 6.28473356299342e-06 MirTarget -0.122070054179173 8.40233358725886e-08 NA NA NA hsa-miR-28-5p RMST -0.14267073663385 0.0497619246260571 -2.44382192551357 5.91433025323596e-08 miRanda -0.449675579460211 0.00994127001403051 NA NA NA hsa-miR-200c-3p RNASEL 2.07038651806183 6.84613386286599e-51 -0.213544684568127 0.00459443349667082 MirTarget -0.110324450999897 2.34215535535053e-10 NA NA NA hsa-miR-200b-3p RND3 2.11744072703209 1.66710572104191e-43 -1.70606216262212 4.40038671490463e-36 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.198068196895994 3.25777991523227e-11 26935796 MicroRNA 200b inhibits epithelial mesenchymal transition and migration of cervical cancer cells by directly targeting RhoE cervical and endocervical cancer hsa-miR-200c-3p RND3 2.07038651806183 6.84613386286599e-51 -1.70606216262212 4.40038671490463e-36 MirTarget;miRNATAP -0.267277520719072 2.46841389713331e-16 23821457 MicroRNA 200c regulates the sensitivity of chemotherapy of gastric cancer SGC7901/DDP cells by directly targeting RhoE gastric cancer hsa-miR-28-5p RNF10 -0.14267073663385 0.0497619246260571 0.183922227767296 7.82104616512277e-06 miRanda -0.14080061678934 3.19560723383641e-13 NA NA NA hsa-miR-141-3p RNF145 2.99777540204168 1.26370498493024e-78 -1.20951940062058 4.13842717523461e-27 MirTarget;TargetScan;miRNATAP -0.198722332291963 2.009833708129e-19 NA NA NA hsa-miR-200a-3p RNF145 2.55218480823434 2.96135446816238e-51 -1.20951940062058 4.13842717523461e-27 MirTarget;miRNATAP -0.205749004274111 1.45296311190587e-21 NA NA NA hsa-miR-205-5p RNF157 -1.70057043266505 1.20976599540743e-09 -2.00541806985687 4.60846624301632e-31 mirMAP;miRNATAP -0.109536144631496 4.26832105954483e-07 NA NA NA hsa-miR-200a-3p RNF168 2.55218480823434 2.96135446816238e-51 -0.508709890368149 4.19269847678057e-05 MirTarget -0.114227451053639 1.38720936170538e-06 NA NA NA hsa-miR-200b-3p RNF168 2.11744072703209 1.66710572104191e-43 -0.508709890368149 4.19269847678057e-05 MirTarget -0.119947320510893 5.2715655177743e-06 NA NA NA hsa-miR-28-5p RNF187 -0.14267073663385 0.0497619246260571 1.01633369097037 2.51780917868843e-52 miRanda -0.142009177223535 2.67776542852784e-05 NA NA NA hsa-miR-141-3p RNF217 2.99777540204168 1.26370498493024e-78 -1.36758471161392 1.37533511512395e-21 mirMAP -0.241595829055983 6.70385753017944e-18 NA NA NA hsa-miR-200a-3p RNF217 2.55218480823434 2.96135446816238e-51 -1.36758471161392 1.37533511512395e-21 mirMAP -0.237702839406249 5.35819185620001e-18 NA NA NA hsa-miR-200b-3p ROCK2 2.11744072703209 1.66710572104191e-43 -1.42053003829191 2.83260805693116e-25 TargetScan -0.238045362418837 5.70621727270586e-16 NA NA NA hsa-miR-141-3p RORA 2.99777540204168 1.26370498493024e-78 -1.02145593857356 1.72079387585623e-26 MirTarget;TargetScan;miRNATAP -0.199558706164586 1.01161812914389e-26 NA NA NA hsa-miR-200a-3p RORA 2.55218480823434 2.96135446816238e-51 -1.02145593857356 1.72079387585623e-26 MirTarget;miRNATAP -0.150615063120472 4.81150009032588e-16 NA NA NA hsa-miR-141-3p RPH3AL 2.99777540204168 1.26370498493024e-78 -0.532864021447757 0.000141948146978237 TargetScan;miRNATAP -0.111449073586394 4.29528394957143e-05 NA NA NA hsa-miR-28-5p RPLP0P2 -0.14267073663385 0.0497619246260571 2.37092895765011 4.02584451390848e-74 miRanda -0.188975627128783 0.00552319763125875 NA NA NA hsa-miR-200b-3p RPS6KA2 2.11744072703209 1.66710572104191e-43 -1.06112701609507 1.34339346025472e-29 TargetScan -0.19593222828491 2.13416782438513e-22 NA NA NA hsa-miR-200c-3p RPS6KA2 2.07038651806183 6.84613386286599e-51 -1.06112701609507 1.34339346025472e-29 miRNATAP -0.281022132531582 1.82177016356237e-38 NA NA NA hsa-let-7e-5p RPS6KA3 0.261471269338985 0.00191077095550257 -1.37237205082117 2.11044411412942e-35 miRNATAP -0.157060484548625 0.000871275403936363 NA NA NA hsa-miR-200b-3p RPS6KA3 2.11744072703209 1.66710572104191e-43 -1.37237205082117 2.11044411412942e-35 MirTarget;TargetScan -0.241869137597393 3.09939082839428e-24 NA NA NA hsa-miR-200c-3p RPS6KA3 2.07038651806183 6.84613386286599e-51 -1.37237205082117 2.11044411412942e-35 MirTarget;miRNATAP -0.26058220909184 2.84165141998717e-23 NA NA NA hsa-miR-28-5p RPS6KA5 -0.14267073663385 0.0497619246260571 -0.957245810152851 9.30300768011881e-15 miRanda -0.174299109370714 0.00356769791900598 NA NA NA hsa-let-7e-5p RRAGD 0.261471269338985 0.00191077095550257 -1.55431301476693 3.93587241444543e-32 miRNATAP -0.247523783844201 9.37821406843417e-06 NA NA NA hsa-miR-28-5p RRM2B -0.14267073663385 0.0497619246260571 0.104156612356596 0.252644515445598 miRanda -0.182015578311515 2.50011313753227e-05 NA NA NA hsa-miR-145-5p RRP7A -2.62703571936687 7.64402900188551e-88 0.515771943484365 2.10349283417685e-08 MirTarget -0.128643745400855 1.7340160303388e-09 NA NA NA hsa-miR-141-3p RSPO3 2.99777540204168 1.26370498493024e-78 -2.999908875854 9.15620294188119e-63 TargetScan -0.522397745128962 7.15675508960835e-49 NA NA NA hsa-miR-145-5p RTKN -2.62703571936687 7.64402900188551e-88 1.29492093513268 4.15162188834918e-51 miRNAWalker2_validate;MirTarget;miRNATAP -0.2656003480696 5.30374903814574e-39 19360360 miR 145 inhibits breast cancer cell growth through RTKN; Subsequently RTKN is identified as a potential miR-145 target by bioinformatics; Using reporter constructs we show that the RTKN 3' untranslated region 3'UTR carries the directly binding site of miR-145; Additionally overexpression of miR-145 in MCF-7 reduces RTKN protein expression as well as mRNA level; Taken together we propose that loss of miR-145 may provide a selective growth advantage for MCF-7 by targeting RTKN breast cancer hsa-miR-132-3p RTN4 -0.0365213889238607 0.668598301088667 -0.601034406966253 3.97552525003937e-25 miRNAWalker2_validate;miRNATAP -0.116553766615971 1.26920618717024e-06 NA NA NA hsa-miR-28-5p RTN4RL1 -0.14267073663385 0.0497619246260571 0.0235441317845835 0.90079236818366 miRanda -0.876981766929322 1.19675645433379e-23 NA NA NA hsa-miR-28-5p RUNDC1 -0.14267073663385 0.0497619246260571 0.295842513834232 0.000580189934087065 miRanda -0.341668097976478 2.11469014255674e-17 NA NA NA hsa-miR-200b-3p RUNX1T1 2.11744072703209 1.66710572104191e-43 -2.57048990739789 4.6896723401076e-41 TargetScan -0.525102670723429 8.69731410815183e-38 NA NA NA hsa-miR-200b-3p RUSC2 2.11744072703209 1.66710572104191e-43 -0.604983797869647 5.6219766920266e-16 TargetScan -0.107269201640875 1.71502756104415e-11 NA NA NA hsa-miR-200c-3p RUSC2 2.07038651806183 6.84613386286599e-51 -0.604983797869647 5.6219766920266e-16 miRNATAP -0.173276147457491 9.6051615693087e-24 NA NA NA hsa-miR-28-5p RWDD2A -0.14267073663385 0.0497619246260571 0.125683302205475 0.0854271541365872 miRanda -0.126326393967917 0.000271630782118608 NA NA NA hsa-miR-132-3p SAMD12 -0.0365213889238607 0.668598301088667 0.749718148942251 7.14387599251026e-08 miRNATAP -0.299298356545202 1.13992180881424e-07 NA NA NA hsa-miR-143-3p SAMD12 -1.23248181631499 4.74160976678504e-28 0.749718148942251 7.14387599251026e-08 mirMAP -0.178438597546587 1.60338713327211e-05 NA NA NA hsa-miR-145-5p SAMD12 -2.62703571936687 7.64402900188551e-88 0.749718148942251 7.14387599251026e-08 miRNATAP -0.148442909122046 4.76308905195642e-06 NA NA NA hsa-miR-200a-3p SAMD4A 2.55218480823434 2.96135446816238e-51 -1.7968635515046 2.10294718067867e-53 miRNATAP -0.300117305654887 6.27824661583868e-40 NA NA NA hsa-miR-141-3p SAMD8 2.99777540204168 1.26370498493024e-78 -1.02596634412093 2.61875625350706e-22 MirTarget;TargetScan;miRNATAP -0.182160884804826 1.12052684348881e-18 NA NA NA hsa-miR-200a-3p SAMD8 2.55218480823434 2.96135446816238e-51 -1.02596634412093 2.61875625350706e-22 MirTarget;miRNATAP -0.171297758446296 3.17805349020134e-17 NA NA NA hsa-miR-200b-3p SAMD8 2.11744072703209 1.66710572104191e-43 -1.02596634412093 2.61875625350706e-22 TargetScan -0.197565264113326 1.84773250583766e-18 NA NA NA hsa-miR-132-3p SAR1A -0.0365213889238607 0.668598301088667 -0.18285075854808 0.000167851775759444 mirMAP -0.121149703713642 5.04790222370096e-10 NA NA NA hsa-miR-28-5p SARM1 -0.14267073663385 0.0497619246260571 -0.621717049421425 7.36140580232588e-06 MirTarget -0.135370002324017 0.0416577679121424 NA NA NA hsa-miR-200b-3p SASH1 2.11744072703209 1.66710572104191e-43 -1.69232748002298 1.81957068409705e-39 MirTarget -0.254770467298297 1.09943557277983e-19 NA NA NA hsa-miR-200c-3p SASH1 2.07038651806183 6.84613386286599e-51 -1.69232748002298 1.81957068409705e-39 MirTarget -0.288172511480447 8.59289682608382e-21 NA NA NA hsa-miR-205-5p SATB2 -1.70057043266505 1.20976599540743e-09 -0.316308874394203 0.0233581925812678 MirTarget;miRNATAP -0.104350721352917 4.67524942547289e-10 NA NA NA hsa-miR-145-5p SCAMP3 -2.62703571936687 7.64402900188551e-88 1.06092398239759 1.16725287486899e-53 MirTarget;miRNATAP -0.211323432014676 1.86893411797385e-38 NA NA NA hsa-miR-143-3p SCAMP4 -1.23248181631499 4.74160976678504e-28 0.614297407813703 1.11749160548696e-19 MirTarget;miRNATAP -0.127239112966251 3.47230368319262e-10 NA NA NA hsa-miR-28-5p SCAMP4 -0.14267073663385 0.0497619246260571 0.614297407813703 1.11749160548696e-19 miRanda -0.22839424792154 2.22663220756444e-12 NA NA NA hsa-miR-28-5p SCAMP5 -0.14267073663385 0.0497619246260571 0.907126239257327 6.22969102491787e-15 miRanda -0.176739481873598 0.00169322267288296 NA NA NA hsa-miR-132-3p SCD -0.0365213889238607 0.668598301088667 -0.986156765000191 5.50753282750432e-07 mirMAP -0.225330291168357 0.00500223303040747 NA NA NA hsa-miR-200b-3p SCD 2.11744072703209 1.66710572104191e-43 -0.986156765000191 5.50753282750432e-07 MirTarget;TargetScan -0.265877662991528 1.72102243290333e-10 NA NA NA hsa-miR-200c-3p SCD 2.07038651806183 6.84613386286599e-51 -0.986156765000191 5.50753282750432e-07 MirTarget;miRNATAP -0.190601860961146 3.57781186937903e-05 NA NA NA hsa-miR-141-3p SCD5 2.99777540204168 1.26370498493024e-78 -0.626458922510552 2.15853670174057e-05 TargetScan -0.105227095511234 0.000251746117462131 NA NA NA hsa-miR-141-3p SCEL 2.99777540204168 1.26370498493024e-78 -1.41198681453485 5.03237774100658e-05 TargetScan -0.210301952939984 0.00197151358120157 NA NA NA hsa-miR-141-3p SCHIP1 2.99777540204168 1.26370498493024e-78 -1.03889489471923 7.51698487725528e-22 MirTarget;TargetScan -0.164884646086568 8.29040323820517e-15 NA NA NA hsa-miR-200a-3p SCHIP1 2.55218480823434 2.96135446816238e-51 -1.03889489471923 7.51698487725528e-22 MirTarget -0.133997805850028 1.61625334224757e-10 NA NA NA hsa-miR-200b-3p SCHIP1 2.11744072703209 1.66710572104191e-43 -1.03889489471923 7.51698487725528e-22 TargetScan -0.149438142582153 1.43924162350809e-10 NA NA NA hsa-miR-200c-3p SCHIP1 2.07038651806183 6.84613386286599e-51 -1.03889489471923 7.51698487725528e-22 miRNATAP -0.195608295610641 1.69420834697768e-14 NA NA NA hsa-let-7e-5p SCN11A 0.261471269338985 0.00191077095550257 -2.67676208496295 1.62723755483509e-55 MirTarget -0.187368580828352 0.0123278852369018 NA NA NA hsa-miR-200b-3p SCN2A 2.11744072703209 1.66710572104191e-43 -3.32315290330292 2.78847355111384e-40 MirTarget;TargetScan -0.351310752333557 2.07724084947455e-10 NA NA NA hsa-miR-200c-3p SCN2A 2.07038651806183 6.84613386286599e-51 -3.32315290330292 2.78847355111384e-40 MirTarget;miRNATAP -0.418155386863787 5.43509582986909e-12 NA NA NA hsa-miR-141-3p SCN2B 2.99777540204168 1.26370498493024e-78 -3.86249794050417 7.57828818937623e-49 MirTarget;miRNATAP -0.801685871012867 2.57898454076002e-56 NA NA NA hsa-miR-200a-3p SCN2B 2.55218480823434 2.96135446816238e-51 -3.86249794050417 7.57828818937623e-49 MirTarget;miRNATAP -0.626929465635717 1.67758276020873e-34 NA NA NA hsa-miR-200b-3p SCN3A 2.11744072703209 1.66710572104191e-43 -4.0564772332002 1.56940161813981e-68 mirMAP -0.558060398300087 7.14821215686193e-27 NA NA NA hsa-miR-200c-3p SCN3A 2.07038651806183 6.84613386286599e-51 -4.0564772332002 1.56940161813981e-68 mirMAP -0.676853275901311 8.17048883620064e-33 NA NA NA hsa-miR-200b-3p SCN3B 2.11744072703209 1.66710572104191e-43 -2.98039696453848 3.54121421070465e-48 TargetScan -0.479929246186831 5.79685044862697e-27 NA NA NA hsa-miR-200a-3p SCN4A 2.55218480823434 2.96135446816238e-51 -3.7981711228472 7.73867930185606e-74 mirMAP -0.496333797561284 4.78412337852023e-32 NA NA NA hsa-let-7e-5p SCN5A 0.261471269338985 0.00191077095550257 -2.93221816182415 3.66462165195964e-47 miRNATAP -0.280168798148466 0.0014893209729453 NA NA NA hsa-miR-200b-3p SCN5A 2.11744072703209 1.66710572104191e-43 -2.93221816182415 3.66462165195964e-47 TargetScan -0.336770374015752 8.44594615745251e-14 NA NA NA hsa-miR-200c-3p SCN5A 2.07038651806183 6.84613386286599e-51 -2.93221816182415 3.66462165195964e-47 miRNATAP -0.404999469957045 2.63224293572836e-16 NA NA NA hsa-miR-141-3p SCN7A 2.99777540204168 1.26370498493024e-78 -3.29515354020856 9.67337839110962e-28 TargetScan -0.735813563614467 8.83134502916712e-37 NA NA NA hsa-miR-200b-3p SCN8A 2.11744072703209 1.66710572104191e-43 -0.61871917362853 0.00211208282168513 MirTarget;TargetScan -0.115241654201241 0.00707728700154836 NA NA NA hsa-miR-141-3p SCN9A 2.99777540204168 1.26370498493024e-78 -2.67160575217133 3.66657527528624e-58 TargetScan -0.568609440263294 1.59170297499728e-71 NA NA NA hsa-miR-28-5p SCUBE1 -0.14267073663385 0.0497619246260571 -1.08277169869843 7.17388900019697e-05 MirTarget;miRanda -0.353971159496076 0.00665611802321946 NA NA NA hsa-miR-141-3p SDC2 2.99777540204168 1.26370498493024e-78 -0.778768700466077 1.75535307602845e-09 MirTarget;TargetScan -0.232334358466436 7.51714963303503e-21 NA NA NA hsa-miR-200a-3p SDC2 2.55218480823434 2.96135446816238e-51 -0.778768700466077 1.75535307602845e-09 MirTarget -0.21141258163233 4.94594068047527e-18 NA NA NA hsa-miR-200b-3p SDC2 2.11744072703209 1.66710572104191e-43 -0.778768700466077 1.75535307602845e-09 TargetScan -0.226356595204484 8.98383680168078e-17 NA NA NA hsa-miR-200c-3p SDC2 2.07038651806183 6.84613386286599e-51 -0.778768700466077 1.75535307602845e-09 miRNATAP -0.285794830279355 6.91675858487873e-22 NA NA NA hsa-miR-141-3p SDK2 2.99777540204168 1.26370498493024e-78 -1.46435315270485 4.01650020293667e-10 mirMAP -0.205731240942938 7.22302381743489e-06 NA NA NA hsa-miR-200a-3p SDK2 2.55218480823434 2.96135446816238e-51 -1.46435315270485 4.01650020293667e-10 mirMAP -0.185757275590572 3.69700258536715e-05 NA NA NA hsa-miR-200b-3p SDK2 2.11744072703209 1.66710572104191e-43 -1.46435315270485 4.01650020293667e-10 TargetScan -0.139164140373925 0.00558333828053964 NA NA NA hsa-miR-200c-3p SDK2 2.07038651806183 6.84613386286599e-51 -1.46435315270485 4.01650020293667e-10 miRNATAP -0.14298077964209 0.0096383002785103 NA NA NA hsa-let-7e-5p SDR42E1 0.261471269338985 0.00191077095550257 -0.403824065892709 0.0765305734587609 MirTarget -0.224608076945618 0.0161177690158543 NA NA NA hsa-miR-132-3p SEC16A -0.0365213889238607 0.668598301088667 0.705401856519326 1.92241123956851e-20 MirTarget -0.176404979637609 1.77842752779033e-08 NA NA NA hsa-miR-28-5p SEC16A -0.14267073663385 0.0497619246260571 0.705401856519326 1.92241123956851e-20 miRanda -0.339102192526052 8.28289847991014e-21 NA NA NA hsa-miR-200b-3p SEC23A 2.11744072703209 1.66710572104191e-43 -0.589349034697416 5.8665748547607e-12 MirTarget;TargetScan -0.236686644918355 7.98169651428987e-42 NA NA NA hsa-miR-200c-3p SEC23A 2.07038651806183 6.84613386286599e-51 -0.589349034697416 5.8665748547607e-12 MirTarget;miRNATAP -0.26275671311765 1.09889084915032e-42 21593139 A computational analysis predicted the 3'-UTR of the SEC23A gene as a potential target for both miR-375 and miR-200c; Here we show that the 3'-UTR of SEC23A mRNA is indeed a target for miR-375 and miR-200c and that both miRNAs downregulate Sec23A protein expression when ectopically expressed in human 293T cells; In primary samples of CaP we found a direct correlation between reduction of SEC23A mRNA and overexpression of miR-375 but not of miR-200c prostate cancer hsa-miR-28-5p SEC23IP -0.14267073663385 0.0497619246260571 0.204057998350036 0.00401511033994364 miRanda -0.135069810091733 6.12254771224588e-05 NA NA NA hsa-miR-132-3p SEC62 -0.0365213889238607 0.668598301088667 -0.312290891804568 3.86333659992841e-07 miRNATAP -0.123123765252642 7.64795543662731e-07 NA NA NA hsa-miR-141-3p SECISBP2L 2.99777540204168 1.26370498493024e-78 -0.969077352009328 5.10594248247564e-24 MirTarget -0.140825618191598 9.41420798004517e-14 NA NA NA hsa-miR-200a-3p SECISBP2L 2.55218480823434 2.96135446816238e-51 -0.969077352009328 5.10594248247564e-24 MirTarget -0.119292496904454 1.51131405229961e-10 NA NA NA hsa-miR-200b-3p SECISBP2L 2.11744072703209 1.66710572104191e-43 -0.969077352009328 5.10594248247564e-24 TargetScan -0.129011002253049 4.87882265619091e-10 NA NA NA hsa-miR-200c-3p SECISBP2L 2.07038651806183 6.84613386286599e-51 -0.969077352009328 5.10594248247564e-24 miRNATAP -0.13748818928854 1.67393652551634e-09 NA NA NA hsa-miR-28-5p SEMA4B -0.14267073663385 0.0497619246260571 0.85463500471788 2.10181293576613e-16 miRanda -0.209395080388177 3.172581117495e-05 NA NA NA hsa-miR-141-3p SEMA6A 2.99777540204168 1.26370498493024e-78 -1.93003615875352 3.37145321593363e-36 MirTarget;TargetScan;miRNATAP -0.295017142668584 3.49342225673855e-22 20420713 The regulation of SEMA6A by miR-141 was verified by a transfection assay kidney renal cell cancer hsa-miR-200a-3p SEMA6A 2.55218480823434 2.96135446816238e-51 -1.93003615875352 3.37145321593363e-36 MirTarget;miRNATAP -0.236193356813241 4.9290635740973e-15 NA NA NA hsa-miR-200b-3p SEMA6D 2.11744072703209 1.66710572104191e-43 -2.4984078728242 1.82880787308589e-46 TargetScan -0.341880354897196 5.97236394597264e-19 NA NA NA hsa-miR-200c-3p SEMA6D 2.07038651806183 6.84613386286599e-51 -2.4984078728242 1.82880787308589e-46 miRNATAP -0.470218612178688 1.67032308177785e-29 NA NA NA hsa-miR-132-3p SEPSECS -0.0365213889238607 0.668598301088667 -0.357928922087793 3.40917594529242e-06 miRNATAP -0.124799364721671 6.55178230218025e-05 NA NA NA hsa-miR-132-3p SEPT8 -0.0365213889238607 0.668598301088667 0.41549071505846 1.97278805144414e-09 miRNATAP -0.102364377478466 0.000286651339081938 NA NA NA hsa-miR-28-5p SERHL -0.14267073663385 0.0497619246260571 -0.645855068242783 0.00196100425848289 miRanda -0.229659952245983 0.00409157837596331 NA NA NA hsa-miR-28-5p SERHL2 -0.14267073663385 0.0497619246260571 -0.343857304888721 0.211470376872396 miRanda;miRNATAP -0.539276926118838 3.69430260584961e-05 NA NA NA hsa-miR-141-3p SERINC1 2.99777540204168 1.26370498493024e-78 -0.865844406740205 3.00220226649236e-27 TargetScan -0.146938409064883 8.17826052881244e-21 NA NA NA hsa-miR-200b-3p SERINC1 2.11744072703209 1.66710572104191e-43 -0.865844406740205 3.00220226649236e-27 MirTarget;TargetScan -0.13406574474583 8.36479476805704e-15 NA NA NA hsa-miR-200c-3p SERINC1 2.07038651806183 6.84613386286599e-51 -0.865844406740205 3.00220226649236e-27 MirTarget;miRNATAP -0.154630523331077 3.45526894382926e-16 NA NA NA hsa-miR-132-3p SERP1 -0.0365213889238607 0.668598301088667 0.461300958894151 1.19013135325051e-13 MirTarget -0.10337463252034 4.86376246104033e-05 NA NA NA hsa-miR-28-5p SERPINA1 -0.14267073663385 0.0497619246260571 0.396626436447673 0.0640799863509273 miRanda -0.203400299005591 0.0465295085588463 NA NA NA hsa-miR-28-5p SERPINA5 -0.14267073663385 0.0497619246260571 -0.519209583936095 0.103183128111987 miRanda -0.774799437153621 2.86498994052742e-07 NA NA NA hsa-miR-200b-3p SESN1 2.11744072703209 1.66710572104191e-43 -0.952506930201764 9.2781623761265e-26 MirTarget;TargetScan -0.15680863005288 9.5895183779347e-16 NA NA NA hsa-miR-200c-3p SESN1 2.07038651806183 6.84613386286599e-51 -0.952506930201764 9.2781623761265e-26 MirTarget;miRNATAP -0.201332360113161 3.52294439599536e-21 24791940 We found that miR-200c overexpression increased cellular radiosensitivity by direct regulation of the oxidative stress response genes PRDX2 GAPB/Nrf2 and SESN1 in ways that inhibits DNA double-strand breaks repair increase levels of reactive oxygen species and upregulate p21 drug resistance lung cancer hsa-miR-28-5p SESN1 -0.14267073663385 0.0497619246260571 -0.952506930201764 9.2781623761265e-26 PITA;miRanda;miRNATAP -0.176225999962169 7.4172729512754e-05 NA NA NA hsa-miR-200b-3p SESN3 2.11744072703209 1.66710572104191e-43 -1.56636935086919 2.7817870595808e-14 MirTarget;TargetScan -0.212089757301576 1.5907832953698e-06 NA NA NA hsa-miR-200c-3p SESN3 2.07038651806183 6.84613386286599e-51 -1.56636935086919 2.7817870595808e-14 MirTarget -0.280493924637921 7.03401362281759e-09 NA NA NA hsa-miR-141-3p SETBP1 2.99777540204168 1.26370498493024e-78 -1.18671410483241 6.28416400335858e-18 miRNATAP -0.200964641932276 8.31017491919566e-14 NA NA NA hsa-miR-200a-3p SETBP1 2.55218480823434 2.96135446816238e-51 -1.18671410483241 6.28416400335858e-18 miRNATAP -0.137920302985048 2.24359593235803e-07 NA NA NA hsa-miR-28-5p SETD3 -0.14267073663385 0.0497619246260571 -0.269540757095891 6.11415488403297e-09 miRanda -0.120126356803789 5.06213015407305e-08 NA NA NA hsa-miR-200b-3p SETD7 2.11744072703209 1.66710572104191e-43 -1.05533462896746 5.56168604809659e-30 TargetScan -0.193672197594332 2.09038302499674e-22 NA NA NA hsa-miR-200c-3p SETD7 2.07038651806183 6.84613386286599e-51 -1.05533462896746 5.56168604809659e-30 miRNATAP -0.225849798047109 3.61659692419147e-25 NA NA NA hsa-miR-28-5p SETD7 -0.14267073663385 0.0497619246260571 -1.05533462896746 5.56168604809659e-30 miRNAWalker2_validate -0.133362643708109 0.00359921691003603 NA NA NA hsa-miR-28-5p SFI1 -0.14267073663385 0.0497619246260571 0.732803203984513 3.09771867450456e-15 miRanda -0.118946816609226 0.00822629167514562 NA NA NA hsa-miR-200b-3p SFMBT2 2.11744072703209 1.66710572104191e-43 -0.841672830700126 6.22220480584314e-07 mirMAP -0.152183088144857 2.29963196691709e-05 NA NA NA hsa-miR-200c-3p SFMBT2 2.07038651806183 6.84613386286599e-51 -0.841672830700126 6.22220480584314e-07 mirMAP -0.116173455070134 0.00337968975690968 NA NA NA hsa-miR-143-3p SFXN1 -1.23248181631499 4.74160976678504e-28 1.00730972646257 1.50510712985854e-31 MirTarget -0.22405349233235 6.56037135572332e-18 NA NA NA hsa-miR-28-5p SFXN1 -0.14267073663385 0.0497619246260571 1.00730972646257 1.50510712985854e-31 miRanda -0.247575672122889 4.90943877345944e-09 NA NA NA hsa-miR-132-3p SFXN2 -0.0365213889238607 0.668598301088667 1.08971879328793 7.30694562473144e-18 miRNAWalker2_validate -0.185076162608237 0.000396745017311297 NA NA NA hsa-miR-28-5p SFXN2 -0.14267073663385 0.0497619246260571 1.08971879328793 7.30694562473144e-18 miRanda -0.338083961196289 3.19538617411812e-08 NA NA NA hsa-miR-200b-3p SGCD 2.11744072703209 1.66710572104191e-43 -1.03490447383629 2.87494382883947e-10 mirMAP -0.34826142665604 2.52588558152801e-24 NA NA NA hsa-miR-200c-3p SGCD 2.07038651806183 6.84613386286599e-51 -1.03490447383629 2.87494382883947e-10 mirMAP -0.428620938419301 1.60025150088249e-30 NA NA NA hsa-miR-200b-3p SGCE 2.11744072703209 1.66710572104191e-43 -1.49325860771838 2.1221860637679e-26 TargetScan -0.244300370365085 6.66444856326283e-16 NA NA NA hsa-miR-200b-3p SGPP1 2.11744072703209 1.66710572104191e-43 -0.63642359336911 7.43044452572603e-09 MirTarget -0.170604440401858 2.09572553299774e-13 NA NA NA hsa-miR-200c-3p SGPP1 2.07038651806183 6.84613386286599e-51 -0.63642359336911 7.43044452572603e-09 MirTarget -0.174220948989911 1.02095538658238e-11 NA NA NA hsa-miR-28-5p SGSH -0.14267073663385 0.0497619246260571 0.131555704868576 0.0379109975142145 miRanda -0.100760708072422 0.000816389719327486 NA NA NA hsa-miR-28-5p SGSM2 -0.14267073663385 0.0497619246260571 -0.226680479630394 0.0136805050128053 miRanda -0.114807613503313 0.00877829877218787 NA NA NA hsa-miR-141-3p SH2B3 2.99777540204168 1.26370498493024e-78 -0.499438088124607 1.87467089235755e-11 MirTarget -0.166743496313069 1.93686167146146e-32 NA NA NA hsa-miR-200a-3p SH2B3 2.55218480823434 2.96135446816238e-51 -0.499438088124607 1.87467089235755e-11 MirTarget -0.153246443865064 2.20024168845711e-28 NA NA NA hsa-miR-132-3p SH3BGRL -0.0365213889238607 0.668598301088667 0.268820390705558 0.0442547470608479 miRNAWalker2_validate -0.348825621436921 7.45784338503323e-11 NA NA NA hsa-miR-28-5p SH3BGRL -0.14267073663385 0.0497619246260571 0.268820390705558 0.0442547470608479 miRanda -0.203847085630723 0.00135374949702198 NA NA NA hsa-miR-145-5p SH3BP1 -2.62703571936687 7.64402900188551e-88 1.05052173414921 7.27611902114297e-26 MirTarget -0.225525243715051 4.36224673034849e-22 NA NA NA hsa-miR-200b-3p SH3PXD2A 2.11744072703209 1.66710572104191e-43 -0.038658231698439 0.664094392746129 TargetScan -0.106571656091514 1.23508204056981e-08 NA NA NA hsa-miR-200c-3p SH3PXD2A 2.07038651806183 6.84613386286599e-51 -0.038658231698439 0.664094392746129 miRNATAP -0.127105807825875 6.12223479557215e-10 NA NA NA hsa-miR-200a-3p SH3PXD2B 2.55218480823434 2.96135446816238e-51 -0.0918386938074187 0.323272517454298 mirMAP -0.101771780917378 6.99474559400164e-09 NA NA NA hsa-miR-132-3p SHANK2 -0.0365213889238607 0.668598301088667 0.177001714184462 0.2071677875336 mirMAP -0.236560746925445 2.9528081954327e-05 NA NA NA hsa-miR-141-3p SHE 2.99777540204168 1.26370498493024e-78 -2.33195369157373 5.84599306122113e-72 mirMAP -0.486915548811075 2.44790653441642e-85 NA NA NA hsa-miR-200a-3p SHE 2.55218480823434 2.96135446816238e-51 -2.33195369157373 5.84599306122113e-72 mirMAP -0.398343171433042 1.13265061497131e-55 NA NA NA hsa-miR-200b-3p SHE 2.11744072703209 1.66710572104191e-43 -2.33195369157373 5.84599306122113e-72 mirMAP -0.408001908358227 2.12715262180061e-46 NA NA NA hsa-miR-200c-3p SHE 2.07038651806183 6.84613386286599e-51 -2.33195369157373 5.84599306122113e-72 mirMAP -0.497551185952991 2.21664107166307e-58 NA NA NA hsa-miR-28-5p SHISA2 -0.14267073663385 0.0497619246260571 -0.0881092399519519 0.754073621031887 MirTarget;miRanda -0.396778641338464 0.00303480221724045 NA NA NA hsa-miR-28-5p SHISA6 -0.14267073663385 0.0497619246260571 -1.68226082206879 2.45685318014832e-13 miRanda;mirMAP -0.234893998087409 0.0346973294930808 NA NA NA hsa-miR-132-3p SHISA9 -0.0365213889238607 0.668598301088667 0.951576190951404 0.00379808291856681 mirMAP -0.382177312486314 0.00416333133981878 NA NA NA hsa-miR-145-5p SHROOM3 -2.62703571936687 7.64402900188551e-88 0.488940714880925 0.000112620796190186 mirMAP -0.110021382390292 0.000187719847175075 NA NA NA hsa-miR-141-3p SHROOM4 2.99777540204168 1.26370498493024e-78 -1.4723405869569 4.07370031193927e-41 TargetScan;mirMAP -0.321914577096056 5.10763512087704e-53 NA NA NA hsa-miR-200a-3p SHROOM4 2.55218480823434 2.96135446816238e-51 -1.4723405869569 4.07370031193927e-41 mirMAP -0.266689248398693 8.59079524569429e-37 NA NA NA hsa-miR-200b-3p SHROOM4 2.11744072703209 1.66710572104191e-43 -1.4723405869569 4.07370031193927e-41 TargetScan;mirMAP -0.284732211007227 8.79595118235852e-34 NA NA NA hsa-miR-200c-3p SHROOM4 2.07038651806183 6.84613386286599e-51 -1.4723405869569 4.07370031193927e-41 mirMAP -0.346006755351506 1.07255488368534e-41 NA NA NA hsa-miR-143-3p SIDT1 -1.23248181631499 4.74160976678504e-28 0.553149117327226 0.00660966681649986 MirTarget;miRNATAP -0.143321839772383 0.017653922212497 NA NA NA hsa-miR-141-3p SIDT2 2.99777540204168 1.26370498493024e-78 -0.851193559016696 4.65419283102878e-33 TargetScan -0.171199217283826 1.69081656394692e-35 NA NA NA hsa-miR-141-3p SIGLEC1 2.99777540204168 1.26370498493024e-78 -0.0595021033403764 0.696119447357449 mirMAP -0.106623293268124 0.000307461298551919 NA NA NA hsa-miR-200a-3p SIGLEC1 2.55218480823434 2.96135446816238e-51 -0.0595021033403764 0.696119447357449 mirMAP -0.100825468497495 0.000506142903565051 NA NA NA hsa-miR-141-3p SIK1 2.99777540204168 1.26370498493024e-78 -0.660834516074939 8.03803537618752e-07 MirTarget;TargetScan;miRNATAP -0.120407310261369 3.92832534879647e-06 27081781 Suppression of SIK1 by miR 141 in human ovarian cancer cell lines and tissues; All three algorithms predicted that miR-141 targets the 3'UTR of SIK1 ovarian cancer hsa-miR-200a-3p SIK2 2.55218480823434 2.96135446816238e-51 -2.29859523998516 3.63982740667992e-106 MirTarget -0.300184866290929 1.69914350725146e-43 NA NA NA hsa-miR-200b-3p SIK2 2.11744072703209 1.66710572104191e-43 -2.29859523998516 3.63982740667992e-106 TargetScan -0.338542850238282 8.04919830600078e-45 NA NA NA hsa-miR-141-3p SIM1 2.99777540204168 1.26370498493024e-78 -3.0298739046154 2.66788857367664e-25 MirTarget -0.449250767916397 5.87636851280913e-15 NA NA NA hsa-miR-200a-3p SIM1 2.55218480823434 2.96135446816238e-51 -3.0298739046154 2.66788857367664e-25 MirTarget -0.341583072487637 1.9010074141214e-09 NA NA NA hsa-miR-28-5p SIPA1L3 -0.14267073663385 0.0497619246260571 1.14456261546297 2.77744871058553e-40 miRanda -0.169840461616851 7.87079640561921e-05 NA NA NA hsa-miR-200b-3p SIRPA 2.11744072703209 1.66710572104191e-43 -1.34210437000021 8.07228675543371e-43 MirTarget -0.217997017483508 1.20741262880431e-24 NA NA NA hsa-miR-200c-3p SIRPA 2.07038651806183 6.84613386286599e-51 -1.34210437000021 8.07228675543371e-43 MirTarget -0.269951000011422 2.49781797486613e-31 NA NA NA hsa-miR-132-3p SIRT1 -0.0365213889238607 0.668598301088667 -0.599221126327341 9.41183428987515e-17 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.102468817666313 0.000556327150746778 NA NA NA hsa-miR-28-5p SIRT3 -0.14267073663385 0.0497619246260571 0.0107489864050141 0.879499666544636 miRanda -0.26212648335716 2.62798701565363e-15 NA NA NA hsa-miR-132-3p SIX4 -0.0365213889238607 0.668598301088667 1.40713523170565 1.66102541379513e-29 miRNATAP -0.234249249590945 7.15026015022472e-06 NA NA NA hsa-miR-143-3p SIX4 -1.23248181631499 4.74160976678504e-28 1.40713523170565 1.66102541379513e-29 miRNATAP -0.280654343388359 1.03720178580904e-13 NA NA NA hsa-miR-132-3p SLAIN2 -0.0365213889238607 0.668598301088667 -0.243398220814224 3.55807577292244e-05 MirTarget -0.104322147405486 1.16604440119203e-05 NA NA NA hsa-let-7e-5p SLAMF6 0.261471269338985 0.00191077095550257 0.20719891500618 0.302774809839517 MirTarget -0.324606241332245 7.57466629830836e-05 NA NA NA hsa-miR-141-3p SLC14A1 2.99777540204168 1.26370498493024e-78 -1.8296766628693 9.14954794554873e-24 TargetScan -0.324237091875429 9.00417486903223e-20 NA NA NA hsa-miR-200b-3p SLC14A1 2.11744072703209 1.66710572104191e-43 -1.8296766628693 9.14954794554873e-24 TargetScan -0.311176163082337 1.74189306346151e-15 NA NA NA hsa-miR-200c-3p SLC14A1 2.07038651806183 6.84613386286599e-51 -1.8296766628693 9.14954794554873e-24 miRNATAP -0.347223954857555 6.45997490756871e-16 NA NA NA hsa-miR-200b-3p SLC16A10 2.11744072703209 1.66710572104191e-43 0.0791934977495485 0.682670800754027 TargetScan -0.114913640195792 0.00513309596711548 NA NA NA hsa-miR-200b-3p SLC16A12 2.11744072703209 1.66710572104191e-43 -3.39848844749063 9.41892581477195e-45 mirMAP -0.456144054108391 1.16013629771253e-17 NA NA NA hsa-miR-200c-3p SLC16A12 2.07038651806183 6.84613386286599e-51 -3.39848844749063 9.41892581477195e-45 mirMAP;miRNATAP -0.561685545355292 5.5854224423554e-22 NA NA NA hsa-miR-200b-3p SLC16A2 2.11744072703209 1.66710572104191e-43 -0.95630968138008 1.13011064231398e-14 TargetScan -0.243509194495021 1.00286443031056e-20 NA NA NA hsa-miR-200c-3p SLC16A2 2.07038651806183 6.84613386286599e-51 -0.95630968138008 1.13011064231398e-14 miRNATAP -0.227815573584986 3.14634930478917e-15 NA NA NA hsa-miR-141-3p SLC16A7 2.99777540204168 1.26370498493024e-78 -3.49994018987621 1.09074280789303e-67 MirTarget;TargetScan;miRNATAP -0.672247379575729 1.31094948652569e-65 NA NA NA hsa-miR-200a-3p SLC16A7 2.55218480823434 2.96135446816238e-51 -3.49994018987621 1.09074280789303e-67 MirTarget;miRNATAP -0.576868164998192 1.64573525873859e-48 NA NA NA hsa-let-7e-5p SLC16A9 0.261471269338985 0.00191077095550257 -0.710563979649714 8.27342348907915e-05 miRNATAP -0.187083801268277 0.0116369335685001 NA NA NA hsa-miR-141-3p SLC18A2 2.99777540204168 1.26370498493024e-78 -0.432909078275727 0.0823913549987578 TargetScan -0.432720969950804 6.8958260273963e-20 NA NA NA hsa-miR-145-5p SLC19A1 -2.62703571936687 7.64402900188551e-88 1.16604634033933 5.44851189110219e-30 mirMAP -0.263706295907264 2.3806645193202e-28 NA NA NA hsa-miR-132-3p SLC1A2 -0.0365213889238607 0.668598301088667 0.459709222651274 0.0428564210643349 mirMAP -0.204646227804735 0.0262101063718871 NA NA NA hsa-miR-145-5p SLC1A2 -2.62703571936687 7.64402900188551e-88 0.459709222651274 0.0428564210643349 miRNATAP -0.112629559267915 0.032963469463296 NA NA NA hsa-miR-132-3p SLC1A4 -0.0365213889238607 0.668598301088667 0.992481327676417 1.78777880902533e-17 MirTarget -0.129126254086282 0.00739673823698838 NA NA NA hsa-miR-145-5p SLC1A4 -2.62703571936687 7.64402900188551e-88 0.992481327676417 1.78777880902533e-17 MirTarget -0.171130691142078 4.20774536235485e-10 NA NA NA hsa-miR-141-3p SLC1A7 2.99777540204168 1.26370498493024e-78 -1.89898960979584 3.58937473841316e-24 MirTarget -0.543968074363888 2.36542113295882e-54 NA NA NA hsa-miR-200a-3p SLC1A7 2.55218480823434 2.96135446816238e-51 -1.89898960979584 3.58937473841316e-24 MirTarget -0.410477326911047 5.07202701771004e-31 NA NA NA hsa-miR-28-5p SLC1A7 -0.14267073663385 0.0497619246260571 -1.89898960979584 3.58937473841316e-24 miRanda -0.203026000903691 0.0271945182255877 NA NA NA hsa-miR-141-3p SLC23A2 2.99777540204168 1.26370498493024e-78 -0.863704929171444 4.7965754192839e-26 TargetScan;miRNATAP -0.121431806885343 5.87856476077752e-14 NA NA NA hsa-miR-200a-3p SLC23A2 2.55218480823434 2.96135446816238e-51 -0.863704929171444 4.7965754192839e-26 miRNATAP -0.124355379652701 4.1008352288661e-15 NA NA NA hsa-miR-200b-3p SLC23A2 2.11744072703209 1.66710572104191e-43 -0.863704929171444 4.7965754192839e-26 TargetScan -0.12919286969364 2.53988985643544e-13 NA NA NA hsa-miR-200c-3p SLC23A2 2.07038651806183 6.84613386286599e-51 -0.863704929171444 4.7965754192839e-26 miRNATAP -0.137994810466558 1.24212912554401e-12 NA NA NA hsa-miR-28-5p SLC24A1 -0.14267073663385 0.0497619246260571 -0.404947269243294 2.78114264738042e-07 miRanda -0.204201346532967 5.23054938284372e-08 NA NA NA hsa-miR-28-5p SLC24A2 -0.14267073663385 0.0497619246260571 4.28884058406051 8.68537645612283e-51 miRNATAP -0.756203538726951 1.66860938215772e-07 NA NA NA hsa-miR-143-3p SLC25A15 -1.23248181631499 4.74160976678504e-28 0.828927038337798 7.36802588367388e-28 MirTarget -0.192046975118445 3.03646402858809e-17 NA NA NA hsa-let-7e-5p SLC25A18 0.261471269338985 0.00191077095550257 -1.79018494608621 2.9938013327351e-21 MirTarget;miRNATAP -0.272926860222763 0.000576749097669365 NA NA NA hsa-let-7e-5p SLC25A27 0.261471269338985 0.00191077095550257 -2.61338542336168 2.5890385711066e-47 MirTarget;miRNATAP -0.156385286230345 0.0467054439842062 NA NA NA hsa-miR-28-5p SLC25A38 -0.14267073663385 0.0497619246260571 0.217477580021136 0.000198540649760527 miRanda -0.206918858185028 4.85128860783084e-14 NA NA NA hsa-miR-28-5p SLC25A45 -0.14267073663385 0.0497619246260571 0.176528287332551 0.0319167814740833 miRanda -0.210753344836521 6.12562039555599e-08 NA NA NA hsa-miR-141-3p SLC25A46 2.99777540204168 1.26370498493024e-78 -0.513843125053454 3.35662306138939e-12 MirTarget -0.100806025704897 2.08947325152253e-12 NA NA NA hsa-miR-200a-3p SLC25A46 2.55218480823434 2.96135446816238e-51 -0.513843125053454 3.35662306138939e-12 MirTarget -0.108934274784796 8.08657424954748e-15 NA NA NA hsa-miR-141-3p SLC26A7 2.99777540204168 1.26370498493024e-78 -1.96069655415711 3.3510326452543e-20 miRNATAP -0.319706155473982 1.97656751822853e-14 NA NA NA hsa-miR-200a-3p SLC26A7 2.55218480823434 2.96135446816238e-51 -1.96069655415711 3.3510326452543e-20 miRNATAP -0.274025498134873 2.78872693365199e-11 NA NA NA hsa-let-7e-5p SLC26A9 0.261471269338985 0.00191077095550257 0.43585561140759 0.119497614724357 miRNATAP -0.324925897878709 0.00455084353108817 NA NA NA hsa-miR-200b-3p SLC2A14 2.11744072703209 1.66710572104191e-43 -0.369226184374921 0.0199885519923262 TargetScan -0.20428957691275 9.51537026310353e-10 NA NA NA hsa-miR-200b-3p SLC2A3 2.11744072703209 1.66710572104191e-43 -0.73181329100781 1.70465019063554e-09 TargetScan -0.246919672638004 2.12061845210017e-22 NA NA NA hsa-miR-200b-3p SLC30A4 2.11744072703209 1.66710572104191e-43 -1.00448774952403 3.52868937206263e-14 mirMAP -0.200097064595424 1.31859002033996e-12 NA NA NA hsa-miR-200c-3p SLC30A4 2.07038651806183 6.84613386286599e-51 -1.00448774952403 3.52868937206263e-14 mirMAP -0.212818921568938 7.23074054227763e-12 NA NA NA hsa-miR-143-3p SLC30A8 -1.23248181631499 4.74160976678504e-28 2.07757230125667 1.63191940569709e-05 MirTarget -0.309492753873375 0.0310214860148672 NA NA NA hsa-miR-28-5p SLC35B1 -0.14267073663385 0.0497619246260571 0.873033341592548 1.03290192975713e-27 MirTarget -0.108854115780261 0.00571534808608037 NA NA NA hsa-miR-200b-3p SLC35B4 2.11744072703209 1.66710572104191e-43 -0.555899913231548 3.16789637131235e-18 MirTarget -0.161992299664321 2.27816701383122e-34 NA NA NA hsa-miR-200c-3p SLC35B4 2.07038651806183 6.84613386286599e-51 -0.555899913231548 3.16789637131235e-18 MirTarget -0.175344958332148 2.91548046690508e-33 NA NA NA hsa-miR-28-5p SLC35E1 -0.14267073663385 0.0497619246260571 0.286066693315876 1.47907134170825e-07 MirTarget -0.118538995778418 4.87277307476773e-06 NA NA NA hsa-miR-200b-3p SLC38A2 2.11744072703209 1.66710572104191e-43 -0.364510037668315 1.63048534493323e-06 TargetScan -0.102576990287577 1.61535790466886e-10 NA NA NA hsa-miR-200b-3p SLC38A4 2.11744072703209 1.66710572104191e-43 -1.2347561385374 5.74044454848711e-08 TargetScan -0.412658111018875 5.13750242493235e-18 NA NA NA hsa-miR-200c-3p SLC38A4 2.07038651806183 6.84613386286599e-51 -1.2347561385374 5.74044454848711e-08 miRNATAP -0.438978338568797 6.49074569786995e-17 NA NA NA hsa-miR-200b-3p SLC39A14 2.11744072703209 1.66710572104191e-43 -0.293760372853095 0.000951980302976168 TargetScan -0.114029097070864 1.12589864919249e-09 NA NA NA hsa-miR-28-5p SLC39A3 -0.14267073663385 0.0497619246260571 0.867086522889385 5.8648511185399e-30 mirMAP -0.172196059958174 4.36927713774559e-06 NA NA NA hsa-miR-28-5p SLC44A5 -0.14267073663385 0.0497619246260571 -0.219753996293499 0.440105379643692 miRanda -0.605333732419013 7.37553109686195e-06 NA NA NA hsa-miR-200b-3p SLC4A4 2.11744072703209 1.66710572104191e-43 -3.22244872974772 4.4074843483247e-37 TargetScan;mirMAP -0.449960835100903 4.16743191764243e-16 NA NA NA hsa-miR-200c-3p SLC4A4 2.07038651806183 6.84613386286599e-51 -3.22244872974772 4.4074843483247e-37 mirMAP -0.625325407454527 2.32713383697721e-25 NA NA NA hsa-miR-141-3p SLC5A3 2.99777540204168 1.26370498493024e-78 -0.728564527931595 1.72377411389955e-12 TargetScan -0.13477828857689 2.10360180609674e-11 NA NA NA hsa-miR-200b-3p SLC5A3 2.11744072703209 1.66710572104191e-43 -0.728564527931595 1.72377411389955e-12 TargetScan -0.170267039473142 6.6340782575264e-15 NA NA NA hsa-let-7e-5p SLC5A6 0.261471269338985 0.00191077095550257 0.135905120433771 0.207653372057497 MirTarget;miRNATAP -0.128424920318789 0.00356808304522269 NA NA NA hsa-let-7e-5p SLC5A9 0.261471269338985 0.00191077095550257 -1.15629785794127 4.7196395690336e-14 miRNATAP -0.231012143194578 0.000283015614996458 NA NA NA hsa-miR-132-3p SLC6A1 -0.0365213889238607 0.668598301088667 0.695876879485252 2.15002129204297e-07 MirTarget;miRNATAP -0.112597107416512 0.0398109322605699 NA NA NA hsa-miR-200c-3p SLC6A1 2.07038651806183 6.84613386286599e-51 0.695876879485252 2.15002129204297e-07 MirTarget;miRNATAP -0.107537028534499 0.000635484155424555 NA NA NA hsa-let-7e-5p SLC6A17 0.261471269338985 0.00191077095550257 0.516244189333382 0.0254872450633986 mirMAP -0.290185654423014 0.00214965071741086 NA NA NA hsa-miR-28-5p SLC6A4 -0.14267073663385 0.0497619246260571 0.832715997717498 0.0306047620635539 miRanda -0.671833824606927 0.000247165301550305 NA NA NA hsa-miR-141-3p SLC9A6 2.99777540204168 1.26370498493024e-78 -1.03941495653485 7.45048393740663e-22 mirMAP -0.185428095619169 1.79953429672627e-18 NA NA NA hsa-miR-200a-3p SLC9A6 2.55218480823434 2.96135446816238e-51 -1.03941495653485 7.45048393740663e-22 mirMAP -0.163168904804147 4.90022989227962e-15 NA NA NA hsa-let-7e-5p SLC9A9 0.261471269338985 0.00191077095550257 -1.61687781411579 6.61792640952173e-47 miRNATAP -0.142569136188712 0.00345040236109798 NA NA NA hsa-let-7e-5p SLCO5A1 0.261471269338985 0.00191077095550257 1.52741878516811 8.47804781115758e-13 miRNATAP -0.198453206131287 0.025232322074515 NA NA NA hsa-miR-200b-3p SLFN5 2.11744072703209 1.66710572104191e-43 -1.27805096676886 2.39933329023955e-18 mirMAP -0.248980820279927 1.4176589281827e-15 NA NA NA hsa-miR-200c-3p SLFN5 2.07038651806183 6.84613386286599e-51 -1.27805096676886 2.39933329023955e-18 mirMAP -0.287583073935163 4.35379942889239e-17 NA NA NA hsa-miR-28-5p SLIT1 -0.14267073663385 0.0497619246260571 -0.429876941630699 0.0690557317419597 mirMAP -0.308631410134809 0.00616075383241358 NA NA NA hsa-miR-200b-3p SLIT2 2.11744072703209 1.66710572104191e-43 -1.96479460453985 2.09695722427889e-22 TargetScan -0.431271705406123 6.75929574300841e-24 NA NA NA hsa-miR-28-5p SMAD3 -0.14267073663385 0.0497619246260571 -0.590930154862025 2.18041656438712e-13 miRNATAP -0.120097254990824 0.00200641803458376 NA NA NA hsa-miR-200b-3p SMAD9 2.11744072703209 1.66710572104191e-43 -2.31742580561337 5.2619763732892e-36 TargetScan -0.433450642046697 1.02300809234532e-27 NA NA NA hsa-miR-28-5p SMARCC2 -0.14267073663385 0.0497619246260571 -0.227365550061606 4.75275814043985e-07 PITA;miRanda;miRNATAP -0.140280402202475 4.7343458860196e-11 NA NA NA hsa-miR-143-3p SMARCD2 -1.23248181631499 4.74160976678504e-28 0.461131630431414 7.22316215755932e-10 miRNATAP -0.147641796808393 2.4100194809989e-11 NA NA NA hsa-miR-132-3p SMARCE1 -0.0365213889238607 0.668598301088667 0.213935788998631 0.00137620770146749 mirMAP -0.102473230493663 0.000149984201126928 NA NA NA hsa-miR-28-5p SMUG1 -0.14267073663385 0.0497619246260571 0.606414386600416 3.40733965995423e-19 miRanda -0.224300530222957 5.5767010594015e-12 NA NA NA hsa-miR-200b-3p SNAI2 2.11744072703209 1.66710572104191e-43 -0.929098872578741 6.81961748391463e-14 TargetScan -0.244585452671317 7.0648050194561e-21 NA NA NA hsa-miR-200c-3p SNAI2 2.07038651806183 6.84613386286599e-51 -0.929098872578741 6.81961748391463e-14 miRNATAP -0.286974732040298 1.03468820627389e-23 NA NA NA hsa-let-7e-5p SNAI3 0.261471269338985 0.00191077095550257 0.556537295965241 1.0419422964738e-05 miRNATAP -0.120633603167637 0.0201511087192481 NA NA NA hsa-miR-28-5p SNAP23 -0.14267073663385 0.0497619246260571 -0.00190318843343817 0.971884090942836 MirTarget;miRanda -0.133008859520424 1.76795790321163e-07 NA NA NA hsa-miR-141-3p SNAP91 2.99777540204168 1.26370498493024e-78 -0.916150785435058 0.000141100985259601 TargetScan;miRNATAP -0.180870642349008 0.000113546085491439 NA NA NA hsa-miR-200a-3p SNAP91 2.55218480823434 2.96135446816238e-51 -0.916150785435058 0.000141100985259601 miRNATAP -0.127118850477594 0.00579873268401079 NA NA NA hsa-miR-28-5p SNPH -0.14267073663385 0.0497619246260571 -0.0326002704691235 0.861189821678195 mirMAP -0.303355623222894 0.000620619893833793 NA NA NA hsa-miR-141-3p SNRK 2.99777540204168 1.26370498493024e-78 -0.9398548825191 1.18370519007903e-44 TargetScan -0.194155270998728 4.73516499977359e-51 NA NA NA hsa-miR-28-5p SNRPN -0.14267073663385 0.0497619246260571 -0.145756373517547 0.194678771019692 miRanda -0.264927747076875 6.445156224726e-07 NA NA NA hsa-miR-200b-3p SNTB2 2.11744072703209 1.66710572104191e-43 -1.09399922860579 1.22882299797836e-47 TargetScan -0.215770115836527 1.04389500756081e-40 NA NA NA hsa-miR-28-5p SNX13 -0.14267073663385 0.0497619246260571 -0.47494994622097 8.24215014257509e-11 miRanda -0.114077424788396 0.00117219357673941 NA NA NA hsa-miR-141-3p SNX18 2.99777540204168 1.26370498493024e-78 -0.742505550345305 2.89782251442901e-29 TargetScan -0.142719409232118 1.24677957306499e-28 NA NA NA hsa-miR-200b-3p SNX18 2.11744072703209 1.66710572104191e-43 -0.742505550345305 2.89782251442901e-29 mirMAP -0.140858096153939 2.03794537861157e-23 NA NA NA hsa-miR-28-5p SNX19 -0.14267073663385 0.0497619246260571 -0.332901048450884 1.43819698027206e-07 miRanda -0.111921626247476 0.00021533004209152 NA NA NA hsa-miR-143-3p SNX27 -1.23248181631499 4.74160976678504e-28 0.480030628325053 5.53186020965717e-13 MirTarget -0.125362745628732 2.2217834639956e-10 NA NA NA hsa-miR-141-3p SOBP 2.99777540204168 1.26370498493024e-78 -1.92250565079978 3.14084346276233e-47 MirTarget;TargetScan -0.419182697707988 7.15340806178977e-61 NA NA NA hsa-miR-200a-3p SOBP 2.55218480823434 2.96135446816238e-51 -1.92250565079978 3.14084346276233e-47 MirTarget -0.357577180834894 1.2988364897917e-44 NA NA NA hsa-miR-141-3p SOCS5 2.99777540204168 1.26370498493024e-78 -0.851523736382883 3.15353102501472e-34 TargetScan -0.114841074509222 1.33359357804587e-16 NA NA NA hsa-miR-141-3p SORBS2 2.99777540204168 1.26370498493024e-78 -1.55748312245062 1.12771049723563e-18 MirTarget;TargetScan -0.14745082012242 2.49637988980632e-05 NA NA NA hsa-miR-28-5p SORCS1 -0.14267073663385 0.0497619246260571 -1.17464209650385 0.00185228663810649 miRanda -0.461554834766473 0.010437753492585 NA NA NA hsa-miR-145-5p SOX11 -2.62703571936687 7.64402900188551e-88 1.93898957713241 1.05695558642746e-11 miRNATAP -0.317617135772699 2.00863161539626e-06 NA NA NA hsa-miR-28-5p SOX12 -0.14267073663385 0.0497619246260571 1.83982761471753 2.43659100122989e-67 mirMAP -0.302573113026 3.09311709304632e-08 NA NA NA hsa-miR-141-3p SOX17 2.99777540204168 1.26370498493024e-78 -2.06470834363699 3.08106763405428e-53 TargetScan -0.426856956954328 5.06746881736312e-61 22921431 Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer; MicroRNA 141 was also found to down-regulate SOX17 expression and activate the WNT signal pathway esophageal cancer hsa-miR-145-5p SOX2 -2.62703571936687 7.64402900188551e-88 1.62824878642595 1.83270623627945e-06 miRNAWalker2_validate;miRTarBase -0.406343012519686 3.02930538603098e-07 20382729;21211035;22098779;25951106;22835608 Finally we provide evidence that EWS-FLI-1 and miRNA-145 function in a mutually repressive feedback loop and identify their common target gene SOX2 in addition to miRNA145 itself as key players in ESFT cell differentiation and tumorigenicity;We also show that miR-145 and SOX2 form a double negative feedback loop in GBM cells potentially creating a bistable system in GBM cells;In this study our miRNA/mRNA-microarray and RT-PCR analysis showed that the expression of miR145 a tumor-suppressive miRNA is inversely correlated with the levels of Oct4 and Sox2 in GBM-CD133+ cells and malignant glioma specimens; We demonstrated that miR145 negatively regulates GBM tumorigenesis by targeting Oct4 and Sox2 in GBM-CD133+;Overexpression of miR 145 5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression; We proposed that miR-145-5p being an important regulator of SOX2 carries a crucial role in PCa tumorigenesis;miR-145 regulates SOX2 and OCT4 translation and p53 regulates miR-145 expression differentiation;;malignant trasformation;tumorigenesis;tumorigenesis; sarcoma;glioblastoma;glioblastoma;prostate cancer;lung squamous cell cancer hsa-miR-145-5p SOX4 -2.62703571936687 7.64402900188551e-88 0.859130686453574 1.16702184409823e-20 mirMAP -0.123552117862411 1.39171106844286e-08 NA NA NA hsa-miR-141-3p SOX5 2.99777540204168 1.26370498493024e-78 -2.72079957365634 5.8401556767149e-39 TargetScan;miRNATAP -0.430365301520418 1.99260254061188e-25 NA NA NA hsa-miR-200a-3p SOX5 2.55218480823434 2.96135446816238e-51 -2.72079957365634 5.8401556767149e-39 miRNATAP -0.351484208239173 8.90274583859572e-18 NA NA NA hsa-miR-200b-3p SOX5 2.11744072703209 1.66710572104191e-43 -2.72079957365634 5.8401556767149e-39 TargetScan -0.364876125408741 1.32814580150601e-15 NA NA NA hsa-miR-141-3p SOX6 2.99777540204168 1.26370498493024e-78 -2.37114135592246 4.35252660248189e-25 TargetScan;mirMAP -0.382619685003343 2.10089851129293e-17 NA NA NA hsa-miR-200a-3p SOX6 2.55218480823434 2.96135446816238e-51 -2.37114135592246 4.35252660248189e-25 mirMAP -0.307739545490966 4.87593377452818e-12 NA NA NA hsa-miR-200b-3p SOX6 2.11744072703209 1.66710572104191e-43 -2.37114135592246 4.35252660248189e-25 TargetScan;mirMAP -0.317329860053222 1.6298235759825e-10 NA NA NA hsa-miR-200c-3p SOX6 2.07038651806183 6.84613386286599e-51 -2.37114135592246 4.35252660248189e-25 mirMAP;miRNATAP -0.413608366364795 2.62937915332749e-14 NA NA NA hsa-miR-28-5p SPAG1 -0.14267073663385 0.0497619246260571 1.21536502852341 1.21867718052225e-27 miRanda;miRNATAP -0.283385630238123 2.1349786014205e-07 NA NA NA hsa-miR-141-3p SPAG9 2.99777540204168 1.26370498493024e-78 -0.551286921853523 5.94847160665692e-12 MirTarget;TargetScan;miRNATAP -0.124232034172895 1.10613748412868e-15 26790956 SPAG9 and miR-141 expression were detected in HCC tissues and cell lines by Western blot and real-time PCR; Dual-luciferase reporter assay was utilized to validate SPAG9 as a direct target gene of miR-141; An inverse correlation was observed between SPAG9 and miR-141 expression in HCC tissues and cell lines; Dual-luciferase reporter assay further showed that SPAG9 was a direct target gene of miR-141; The ectopic expression of miR-141 could markedly suppress SPAG9 expression in HCC cells; MiR-141 overexpression also resulted in significantly reduced cell proliferation invasion and migration and imitation of the SPAG9 knockdown effects on HCC cells; Furthermore SPAG9 restoration in miR-141-expressing cells sufficiently attenuated the tumor-suppressive effects of miR-141; Finally JNK activity was found to be reduced by miR-141 overexpression the same way as by SPAG9 silencing; MiR-141 suppression may cause aberrant expression of SPAG9 and promote HCC tumorigenesis via JNK pathway tumorigenesis liver cancer hsa-miR-200a-3p SPAG9 2.55218480823434 2.96135446816238e-51 -0.551286921853523 5.94847160665692e-12 MirTarget;miRNATAP -0.133325885170975 1.35903070345216e-18 26797273 MicroRNA 200a 3p suppresses tumor proliferation and induces apoptosis by targeting SPAG9 in renal cell carcinoma; Our study tried to explore the mediator of miR-200a-3p a tumor suppressing miRNA on SPAG9 expression and renal cell proliferation and apoptosis; In addition our study uncovered that miR-200a-3p directly regulates oncogenic SPAG9 in 786-O and ACHN cells; Understanding of oncogenic SPAG9 regulated by miR-200a-3p might be beneficial to reveal new therapeutic targets for RCC kidney renal cell cancer hsa-miR-200b-3p SPAG9 2.11744072703209 1.66710572104191e-43 -0.551286921853523 5.94847160665692e-12 MirTarget;TargetScan -0.146710934379247 3.23809849372727e-18 NA NA NA hsa-miR-200c-3p SPAG9 2.07038651806183 6.84613386286599e-51 -0.551286921853523 5.94847160665692e-12 MirTarget;miRNATAP -0.146454226449591 3.58899801462239e-15 NA NA NA hsa-miR-28-5p SPARC -0.14267073663385 0.0497619246260571 0.260111874990256 0.034213916848521 miRanda -0.128260261137617 0.0285436818829644 NA NA NA hsa-miR-28-5p SPATA2 -0.14267073663385 0.0497619246260571 0.422408617204912 3.11792520748896e-12 miRanda -0.131824028628949 5.76197976366993e-06 NA NA NA hsa-miR-28-5p SPATA20 -0.14267073663385 0.0497619246260571 0.44118485989573 8.656953078129e-05 miRanda -0.500777774110776 1.23992642174534e-21 NA NA NA hsa-miR-28-5p SPATA5L1 -0.14267073663385 0.0497619246260571 0.178145637609615 0.00049083620708605 miRanda -0.102077664728975 2.56348708697251e-05 NA NA NA hsa-miR-145-5p SPATS2 -2.62703571936687 7.64402900188551e-88 0.846399001925744 1.6430729270988e-46 MirTarget -0.158918942612411 8.89890005924841e-30 NA NA NA hsa-miR-28-5p SPEF2 -0.14267073663385 0.0497619246260571 0.0180087182537036 0.892221023811872 miRanda -0.441848875618062 1.50726561843833e-12 NA NA NA hsa-miR-200b-3p SPG20 2.11744072703209 1.66710572104191e-43 -1.1412579469464 6.97839818554614e-36 TargetScan -0.155589883361788 5.54240779007804e-15 NA NA NA hsa-miR-28-5p SPHK2 -0.14267073663385 0.0497619246260571 0.706094211869426 4.02352204528931e-17 mirMAP -0.232571634666738 8.87397180654698e-09 NA NA NA hsa-let-7e-5p SPN 0.261471269338985 0.00191077095550257 0.0101792377906609 0.943004960884371 miRNAWalker2_validate -0.190776437753625 0.00103187988120867 NA NA NA hsa-miR-28-5p SPNS1 -0.14267073663385 0.0497619246260571 0.863726955106674 4.25847180628551e-32 miRanda -0.133019080595056 0.000236964129139015 NA NA NA hsa-miR-141-3p SPRED1 2.99777540204168 1.26370498493024e-78 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.161162915971162 2.35918858864777e-19 NA NA NA hsa-miR-200a-3p SPRED1 2.55218480823434 2.96135446816238e-51 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.131532261379301 1.11338813569557e-13 NA NA NA hsa-miR-200b-3p SPRED1 2.11744072703209 1.66710572104191e-43 -0.73987992932487 1.32055673934219e-15 TargetScan -0.142284251884432 5.32725114828085e-13 NA NA NA hsa-miR-200c-3p SPRED1 2.07038651806183 6.84613386286599e-51 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.191613645318991 5.16049176566749e-19 NA NA NA hsa-miR-141-3p SPRY3 2.99777540204168 1.26370498493024e-78 -0.743897577510337 8.22794586143845e-18 mirMAP -0.108375435062231 1.80222465712053e-10 NA NA NA hsa-miR-200a-3p SPRY3 2.55218480823434 2.96135446816238e-51 -0.743897577510337 8.22794586143845e-18 mirMAP -0.106245731360012 1.86180122777501e-10 NA NA NA hsa-miR-200b-3p SPRY3 2.11744072703209 1.66710572104191e-43 -0.743897577510337 8.22794586143845e-18 mirMAP -0.116765535305546 3.07731809687366e-10 NA NA NA hsa-miR-200c-3p SPRY3 2.07038651806183 6.84613386286599e-51 -0.743897577510337 8.22794586143845e-18 mirMAP -0.127854270188269 3.67091697628272e-10 NA NA NA hsa-miR-141-3p SPRY4 2.99777540204168 1.26370498493024e-78 -0.269797609928706 0.00344671028336406 TargetScan;miRNATAP -0.136262756960658 1.26981399486428e-14 NA NA NA hsa-miR-200a-3p SPRY4 2.55218480823434 2.96135446816238e-51 -0.269797609928706 0.00344671028336406 mirMAP;miRNATAP -0.135104834299242 6.51393438180949e-15 NA NA NA hsa-miR-28-5p SQSTM1 -0.14267073663385 0.0497619246260571 0.337430896843218 6.84019405897406e-06 miRanda -0.184705196991679 2.22156890650776e-07 NA NA NA hsa-miR-132-3p SRCIN1 -0.0365213889238607 0.668598301088667 1.01769401933761 6.04876320869876e-10 mirMAP -0.219036349748184 0.00112185619133684 NA NA NA hsa-miR-143-3p SRCIN1 -1.23248181631499 4.74160976678504e-28 1.01769401933761 6.04876320869876e-10 MirTarget -0.20983802524255 1.86327976361736e-05 NA NA NA hsa-miR-28-5p SRCIN1 -0.14267073663385 0.0497619246260571 1.01769401933761 6.04876320869876e-10 miRanda -0.442078106154846 1.85478243537203e-08 NA NA NA hsa-miR-145-5p SRD5A2 -2.62703571936687 7.64402900188551e-88 1.69756588590754 3.36235577298704e-15 MirTarget -0.159499147767344 0.00173482769317921 NA NA NA hsa-miR-28-5p SSBP2 -0.14267073663385 0.0497619246260571 -0.688186904830189 6.78722403001534e-13 miRanda -0.298326289348499 7.2427398305492e-11 NA NA NA hsa-miR-200c-3p SSH2 2.07038651806183 6.84613386286599e-51 -0.339977737557532 0.000104804788074283 miRNATAP -0.14112426863106 3.20663257982363e-12 NA NA NA hsa-miR-141-3p SSTR1 2.99777540204168 1.26370498493024e-78 -3.37367224819205 2.06078044997098e-50 mirMAP -0.622198652649971 8.64842741773479e-45 NA NA NA hsa-miR-200a-3p SSTR1 2.55218480823434 2.96135446816238e-51 -3.37367224819205 2.06078044997098e-50 mirMAP -0.500478170759875 1.56875067366482e-29 NA NA NA hsa-miR-200b-3p ST3GAL2 2.11744072703209 1.66710572104191e-43 -0.172671109983257 0.0320901924647913 MirTarget;TargetScan -0.153045431167801 4.96856440917504e-20 NA NA NA hsa-miR-200c-3p ST3GAL2 2.07038651806183 6.84613386286599e-51 -0.172671109983257 0.0320901924647913 MirTarget;miRNATAP -0.205857076845866 6.8218272605097e-30 NA NA NA hsa-miR-141-3p ST3GAL3 2.99777540204168 1.26370498493024e-78 -0.858146158856265 5.25971005002269e-27 MirTarget;TargetScan;miRNATAP -0.17540419708461 6.94968958273019e-30 NA NA NA hsa-miR-200a-3p ST3GAL3 2.55218480823434 2.96135446816238e-51 -0.858146158856265 5.25971005002269e-27 MirTarget;miRNATAP -0.106516924911605 6.72426266181531e-12 NA NA NA hsa-miR-141-3p ST3GAL5 2.99777540204168 1.26370498493024e-78 -0.518926657940599 1.34427760582184e-06 MirTarget;TargetScan -0.164414450467899 1.67797024775632e-15 NA NA NA hsa-miR-200a-3p ST3GAL5 2.55218480823434 2.96135446816238e-51 -0.518926657940599 1.34427760582184e-06 MirTarget -0.15050353403089 1.25005298897729e-13 NA NA NA hsa-miR-141-3p ST6GALNAC3 2.99777540204168 1.26370498493024e-78 -2.13511757496546 6.942886718098e-66 mirMAP -0.389752882216162 6.53349343476067e-57 NA NA NA hsa-miR-200a-3p ST6GALNAC3 2.55218480823434 2.96135446816238e-51 -2.13511757496546 6.942886718098e-66 mirMAP -0.326445365529675 2.95714418473664e-40 NA NA NA hsa-miR-200b-3p ST8SIA2 2.11744072703209 1.66710572104191e-43 -1.82054064267358 1.68353865315065e-12 mirMAP -0.244977760956555 9.38991697162383e-06 NA NA NA hsa-miR-200c-3p ST8SIA2 2.07038651806183 6.84613386286599e-51 -1.82054064267358 1.68353865315065e-12 mirMAP -0.281252408542962 3.68609966901047e-06 NA NA NA hsa-let-7e-5p STAB2 0.261471269338985 0.00191077095550257 -4.40910369469475 2.54159806926087e-59 miRNATAP -0.365752515576895 0.00224063124894588 NA NA NA hsa-miR-200b-3p STARD13 2.11744072703209 1.66710572104191e-43 -0.854533102709033 1.74673553708564e-17 TargetScan -0.165110996329142 1.20047359568824e-14 NA NA NA hsa-miR-200b-3p STARD8 2.11744072703209 1.66710572104191e-43 -1.14973449373513 2.16206820659553e-34 mirMAP -0.269052095440804 2.92934549316219e-42 NA NA NA hsa-miR-200c-3p STARD8 2.07038651806183 6.84613386286599e-51 -1.14973449373513 2.16206820659553e-34 mirMAP -0.340394258716721 1.57053362762849e-57 NA NA NA hsa-miR-145-5p STAT1 -2.62703571936687 7.64402900188551e-88 0.84704946611897 1.52503088632031e-12 miRNAWalker2_validate;miRTarBase -0.190431855359047 8.49731192294897e-12 20098684 MicroRNA 145 targets YES and STAT1 in colon cancer cells; Both YES and STAT1 were verified as direct miR-145 targets colon cancer hsa-miR-141-3p STAT4 2.99777540204168 1.26370498493024e-78 -0.980704169210314 7.75895883125847e-09 MirTarget;TargetScan -0.240950533860277 2.29630203380521e-13 24732377 Down regulation of miR 141 induced by helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4; A luciferase assay revealed that miR-141 was directly bound to the 3'-untranslated regions 3'-UTR of STAT4; Over-expression of STAT4 was used to mimic miR-141 action in the invasion of gastric cancer; MiR-141 may play a pivotal role in controlling gastric cancer invasion through regulating STAT4 and maybe a potential target to treat gastric cancer gastric cancer hsa-miR-200a-3p STAT4 2.55218480823434 2.96135446816238e-51 -0.980704169210314 7.75895883125847e-09 MirTarget -0.213924427791527 3.73823510549369e-11 NA NA NA hsa-miR-141-3p STAT5A 2.99777540204168 1.26370498493024e-78 -1.42714993428393 2.70689276768275e-43 MirTarget;TargetScan;miRNATAP -0.249467858863614 1.60720902974445e-34 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-200a-3p STAT5A 2.55218480823434 2.96135446816238e-51 -1.42714993428393 2.70689276768275e-43 MirTarget;miRNATAP -0.17649399523056 5.36082676998248e-18 NA NA NA hsa-miR-141-3p STAT5B 2.99777540204168 1.26370498493024e-78 -1.26603570026736 3.18742679965819e-62 MirTarget;TargetScan;miRNATAP -0.210194932545999 8.1601418441609e-44 NA NA NA hsa-miR-200a-3p STAT5B 2.55218480823434 2.96135446816238e-51 -1.26603570026736 3.18742679965819e-62 MirTarget;miRNATAP -0.166364658066859 5.40700398258099e-28 NA NA NA hsa-miR-28-5p STC1 -0.14267073663385 0.0497619246260571 0.0174437759200483 0.927534883709258 miRanda -0.420438503201195 3.76779887199724e-06 NA NA NA hsa-miR-141-3p STEAP2 2.99777540204168 1.26370498493024e-78 -1.11890369934626 3.76224373550894e-10 MirTarget;miRNATAP -0.205997200933082 3.30030033233962e-09 NA NA NA hsa-miR-200a-3p STEAP2 2.55218480823434 2.96135446816238e-51 -1.11890369934626 3.76224373550894e-10 MirTarget;miRNATAP -0.159119364463283 3.49657847105165e-06 NA NA NA hsa-miR-28-5p STK16 -0.14267073663385 0.0497619246260571 0.402504151002991 9.90775556523305e-12 miRanda -0.188797357633773 1.9631444476179e-11 NA NA NA hsa-miR-28-5p STK36 -0.14267073663385 0.0497619246260571 0.377236149506294 6.85193611730421e-06 miRanda -0.22144955704607 2.71205283096417e-08 NA NA NA hsa-miR-28-5p STOM -0.14267073663385 0.0497619246260571 -0.649999293476048 7.55025346293203e-11 miRanda -0.145691676720967 0.00243906835735245 NA NA NA hsa-miR-28-5p STRADB -0.14267073663385 0.0497619246260571 -0.643341720695693 4.11123485334864e-15 miRanda -0.154073446657361 9.90677268422725e-05 NA NA NA hsa-miR-141-3p STX2 2.99777540204168 1.26370498493024e-78 -0.477957124111536 3.91337532111255e-12 MirTarget;TargetScan;miRNATAP -0.1518300843814 2.67844057033477e-31 NA NA NA hsa-miR-200a-3p STX2 2.55218480823434 2.96135446816238e-51 -0.477957124111536 3.91337532111255e-12 MirTarget;miRNATAP -0.126548625374411 1.47734745929069e-22 NA NA NA hsa-miR-141-3p STX7 2.99777540204168 1.26370498493024e-78 -0.743223991128262 2.73753963588225e-35 TargetScan -0.126828124594219 4.50943871008587e-27 NA NA NA hsa-miR-141-3p STXBP1 2.99777540204168 1.26370498493024e-78 -1.33274174366283 2.07488419131401e-34 MirTarget;TargetScan;miRNATAP -0.248937943669874 1.26671983744587e-31 NA NA NA hsa-miR-200a-3p STXBP1 2.55218480823434 2.96135446816238e-51 -1.33274174366283 2.07488419131401e-34 MirTarget;miRNATAP -0.168343665572698 2.97110746534341e-15 NA NA NA hsa-miR-141-3p STXBP5 2.99777540204168 1.26370498493024e-78 -0.532336390386523 4.81218144261821e-08 TargetScan -0.110366755333999 5.74502684955627e-09 NA NA NA hsa-miR-145-5p STXBP5L -2.62703571936687 7.64402900188551e-88 0.899525965907459 0.000425870656798328 mirMAP -0.129274080853634 0.0299200533429409 NA NA NA hsa-miR-205-5p STXBP5L -1.70057043266505 1.20976599540743e-09 0.899525965907459 0.000425870656798328 mirMAP -0.101910915662009 0.00100630944629343 NA NA NA hsa-miR-200b-3p STXBP6 2.11744072703209 1.66710572104191e-43 -2.77290323792718 2.07722835803603e-35 TargetScan -0.481521083520953 1.64050653217567e-23 NA NA NA hsa-miR-141-3p SV2B 2.99777540204168 1.26370498493024e-78 -2.64738575414116 9.73898135717167e-43 MirTarget -0.49105538801218 1.48594053422606e-38 NA NA NA hsa-miR-200a-3p SV2B 2.55218480823434 2.96135446816238e-51 -2.64738575414116 9.73898135717167e-43 MirTarget -0.395015308653402 1.22114875893223e-25 NA NA NA hsa-miR-200b-3p SV2B 2.11744072703209 1.66710572104191e-43 -2.64738575414116 9.73898135717167e-43 mirMAP -0.402524915095762 1.4496305523351e-21 NA NA NA hsa-miR-200c-3p SV2B 2.07038651806183 6.84613386286599e-51 -2.64738575414116 9.73898135717167e-43 mirMAP -0.487872675991375 3.79946115212636e-26 NA NA NA hsa-miR-141-3p SVIL 2.99777540204168 1.26370498493024e-78 -1.02042711975721 4.10242843113864e-27 miRNATAP -0.187216915966905 4.02090130596551e-24 NA NA NA hsa-miR-200a-3p SVIL 2.55218480823434 2.96135446816238e-51 -1.02042711975721 4.10242843113864e-27 miRNATAP -0.150481698888998 2.11066073818249e-16 NA NA NA hsa-miR-200c-3p SWAP70 2.07038651806183 6.84613386286599e-51 -0.706858976777302 7.40269447194177e-24 MirTarget -0.109524232507323 4.73367128652567e-11 NA NA NA hsa-miR-145-5p SYAP1 -2.62703571936687 7.64402900188551e-88 0.828697534956492 3.30677430453784e-28 mirMAP -0.143769801168884 5.86228044774905e-16 NA NA NA hsa-miR-28-5p SYBU -0.14267073663385 0.0497619246260571 -0.572312328428279 0.00218363989087214 miRanda -0.730310895089721 7.30811267796815e-17 NA NA NA hsa-miR-28-5p SYCE2 -0.14267073663385 0.0497619246260571 1.83143884411464 1.42387265552736e-34 miRanda -0.236968196033737 0.00140462299853398 NA NA NA hsa-miR-200b-3p SYDE1 2.11744072703209 1.66710572104191e-43 -0.59031661571319 1.56581328075237e-10 MirTarget;TargetScan -0.200677938410172 1.38895949195538e-25 NA NA NA hsa-miR-200c-3p SYDE1 2.07038651806183 6.84613386286599e-51 -0.59031661571319 1.56581328075237e-10 MirTarget;miRNATAP -0.260351825688736 7.16529254274237e-36 NA NA NA hsa-miR-200c-3p SYNC 2.07038651806183 6.84613386286599e-51 -0.153981352248731 0.325479128978546 MirTarget -0.200356002288168 3.29332931696018e-08 NA NA NA hsa-miR-28-5p SYNC -0.14267073663385 0.0497619246260571 -0.153981352248731 0.325479128978546 miRanda -0.265851291789184 0.000355254741684812 NA NA NA hsa-miR-141-3p SYNPO2 2.99777540204168 1.26370498493024e-78 -2.92464505004565 6.88376936514486e-65 TargetScan;miRNATAP -0.527133057978033 1.82869178124705e-54 NA NA NA hsa-miR-200a-3p SYNPO2 2.55218480823434 2.96135446816238e-51 -2.92464505004565 6.88376936514486e-65 miRNATAP -0.445183095064665 2.64885409598501e-39 NA NA NA hsa-miR-200b-3p SYNPO2 2.11744072703209 1.66710572104191e-43 -2.92464505004565 6.88376936514486e-65 mirMAP -0.468932116133846 4.68425320878927e-35 NA NA NA hsa-miR-200b-3p SYT11 2.11744072703209 1.66710572104191e-43 -0.486909650674836 1.01969242501068e-07 mirMAP -0.208477723087087 2.58516888064497e-28 NA NA NA hsa-miR-200c-3p SYT11 2.07038651806183 6.84613386286599e-51 -0.486909650674836 1.01969242501068e-07 mirMAP -0.244170422411085 3.31298673937728e-32 NA NA NA hsa-miR-28-5p SYT13 -0.14267073663385 0.0497619246260571 2.91774638341289 1.4380254498439e-12 miRanda -0.705964334486968 0.000384111843790838 NA NA NA hsa-miR-141-3p SYT2 2.99777540204168 1.26370498493024e-78 -1.13874869529916 2.05373997501291e-19 mirMAP -0.197988556417279 1.1500448885582e-15 NA NA NA hsa-miR-200a-3p SYT2 2.55218480823434 2.96135446816238e-51 -1.13874869529916 2.05373997501291e-19 mirMAP -0.165133080686438 1.26263835227673e-11 NA NA NA hsa-miR-141-3p SYT6 2.99777540204168 1.26370498493024e-78 -0.478835360484974 0.00434900423818834 MirTarget;TargetScan -0.102595700017579 0.00168883200818246 NA NA NA hsa-miR-28-5p SYTL4 -0.14267073663385 0.0497619246260571 -0.26631400934631 0.0393829139575531 miRanda -0.456650470025982 5.39086292604251e-14 NA NA NA hsa-miR-141-3p TAC1 2.99777540204168 1.26370498493024e-78 -2.51990451890503 7.35598887494912e-17 MirTarget -0.510515327861923 3.50948483640586e-18 NA NA NA hsa-miR-200a-3p TAC1 2.55218480823434 2.96135446816238e-51 -2.51990451890503 7.35598887494912e-17 MirTarget -0.352757652820407 1.41720573149812e-09 NA NA NA hsa-miR-132-3p TADA2B -0.0365213889238607 0.668598301088667 0.024204918444835 0.690929682933946 MirTarget -0.103253606572094 2.5053517326196e-05 NA NA NA hsa-miR-145-5p TAGLN2 -2.62703571936687 7.64402900188551e-88 0.920994827466144 3.75682216697375e-27 MirTarget;miRNATAP -0.144596671924885 8.47351125918979e-13 NA NA NA hsa-miR-143-3p TANC2 -1.23248181631499 4.74160976678504e-28 0.645784897636979 5.11106873490809e-07 miRNATAP -0.113614128743553 0.00300190338808008 NA NA NA hsa-miR-28-5p TANC2 -0.14267073663385 0.0497619246260571 0.645784897636979 5.11106873490809e-07 miRanda -0.241961164649315 8.34629992228275e-05 NA NA NA hsa-miR-200b-3p TAOK1 2.11744072703209 1.66710572104191e-43 -1.02699433731773 5.06740042441332e-08 MirTarget;TargetScan;mirMAP -0.220708220833645 3.52423430114308e-08 NA NA NA hsa-miR-200c-3p TAOK1 2.07038651806183 6.84613386286599e-51 -1.02699433731773 5.06740042441332e-08 MirTarget;mirMAP;miRNATAP -0.172415220398364 9.65606194605702e-05 NA NA NA hsa-miR-28-5p TAOK2 -0.14267073663385 0.0497619246260571 0.433430948462074 3.95755269074194e-12 miRanda -0.25995291139941 1.14651902610124e-18 NA NA NA hsa-miR-145-5p TARS2 -2.62703571936687 7.64402900188551e-88 1.02415963397561 8.39575134988038e-47 MirTarget -0.216106062510888 4.29051016682803e-38 NA NA NA hsa-miR-28-5p TARS2 -0.14267073663385 0.0497619246260571 1.02415963397561 8.39575134988038e-47 miRanda -0.122295473108918 0.000663078548652261 NA NA NA hsa-miR-28-5p TAT -0.14267073663385 0.0497619246260571 -4.1700211703831 1.44104525158907e-18 miRanda -0.477313247620828 0.038945109081538 NA NA NA hsa-miR-28-5p TBC1D16 -0.14267073663385 0.0497619246260571 -0.318134709463815 0.000815367768719466 miRNATAP -0.104612291360706 0.0211490584133685 NA NA NA hsa-miR-132-3p TBC1D9 -0.0365213889238607 0.668598301088667 0.311454954290858 0.115143760209625 miRNAWalker2_validate -0.337736020344779 2.32246246169984e-05 NA NA NA hsa-miR-200b-3p TBX18 2.11744072703209 1.66710572104191e-43 -1.63497901262982 4.33685552288116e-24 MirTarget -0.356983239935636 1.90998627232965e-25 NA NA NA hsa-miR-200c-3p TBX18 2.07038651806183 6.84613386286599e-51 -1.63497901262982 4.33685552288116e-24 MirTarget -0.455031771225271 2.22536796217204e-34 NA NA NA hsa-miR-28-5p TBX2 -0.14267073663385 0.0497619246260571 0.129922787207087 0.243301824733681 miRanda -0.140703521954603 0.00794171052002852 NA NA NA hsa-miR-200b-3p TBX5 2.11744072703209 1.66710572104191e-43 -0.839510042139524 1.30543205804252e-07 TargetScan -0.315819038113751 1.72067633890594e-21 NA NA NA hsa-miR-28-5p TC2N -0.14267073663385 0.0497619246260571 0.0475147882231264 0.727197958425978 miRanda -0.184267973480312 0.00446523882844074 NA NA NA hsa-miR-141-3p TCF4 2.99777540204168 1.26370498493024e-78 -1.10005019362634 5.35039549171217e-24 MirTarget;TargetScan;miRNATAP -0.337314487736614 5.38689179335519e-63 NA NA NA hsa-miR-200a-3p TCF4 2.55218480823434 2.96135446816238e-51 -1.10005019362634 5.35039549171217e-24 MirTarget;miRNATAP -0.294925507037607 1.242682437187e-48 NA NA NA hsa-miR-200b-3p TCF4 2.11744072703209 1.66710572104191e-43 -1.10005019362634 5.35039549171217e-24 TargetScan;mirMAP -0.313264475548158 5.36537052084636e-44 NA NA NA hsa-miR-200c-3p TCF4 2.07038651806183 6.84613386286599e-51 -1.10005019362634 5.35039549171217e-24 mirMAP;miRNATAP -0.373371468855674 1.75142955154369e-52 NA NA NA hsa-miR-141-3p TCF7L1 2.99777540204168 1.26370498493024e-78 -1.43757533529955 1.98162937384072e-20 miRNAWalker2_validate -0.199972471420516 6.28430074006789e-11 NA NA NA hsa-miR-200a-3p TCF7L1 2.55218480823434 2.96135446816238e-51 -1.43757533529955 1.98162937384072e-20 miRNAWalker2_validate -0.150558299078396 6.03400969336786e-07 NA NA NA hsa-miR-200b-3p TCF7L1 2.11744072703209 1.66710572104191e-43 -1.43757533529955 1.98162937384072e-20 miRNAWalker2_validate -0.168143697293025 5.41553060367198e-07 NA NA NA hsa-miR-200c-3p TCF7L1 2.07038651806183 6.84613386286599e-51 -1.43757533529955 1.98162937384072e-20 miRNAWalker2_validate -0.229533628135833 4.20710186780113e-10 NA NA NA hsa-miR-28-5p TCTA -0.14267073663385 0.0497619246260571 0.20213938843336 0.00613628359574618 miRanda -0.198402744330933 1.27950291789586e-08 NA NA NA hsa-miR-141-3p TEAD1 2.99777540204168 1.26370498493024e-78 -1.39931853829988 3.11111186209198e-44 mirMAP -0.263313439559027 3.49779352863607e-41 NA NA NA hsa-miR-200a-3p TEAD1 2.55218480823434 2.96135446816238e-51 -1.39931853829988 3.11111186209198e-44 mirMAP -0.223034041783001 2.66140349888619e-30 NA NA NA hsa-miR-200b-3p TEAD1 2.11744072703209 1.66710572104191e-43 -1.39931853829988 3.11111186209198e-44 TargetScan -0.246914111025017 5.14311134476288e-30 NA NA NA hsa-miR-200c-3p TEAD1 2.07038651806183 6.84613386286599e-51 -1.39931853829988 3.11111186209198e-44 miRNATAP -0.302039970867764 1.97528873326621e-37 NA NA NA hsa-miR-28-5p TEX14 -0.14267073663385 0.0497619246260571 0.931242979008404 9.10679550289147e-05 miRanda;miRNATAP -0.36038453972202 0.00152927774957985 NA NA NA hsa-miR-28-5p TEX9 -0.14267073663385 0.0497619246260571 0.0509689822456678 0.700082142899211 miRanda -0.1670711645078 0.00798015597379457 NA NA NA hsa-miR-200b-3p TFE3 2.11744072703209 1.66710572104191e-43 -0.446367250657458 1.19299069465675e-20 MirTarget -0.111070475427735 1.7031702324767e-28 NA NA NA hsa-miR-200b-3p TFPI 2.11744072703209 1.66710572104191e-43 -2.24834899858951 2.16889870319697e-54 MirTarget -0.448339699307029 2.56263287697859e-47 NA NA NA hsa-miR-200c-3p TFPI 2.07038651806183 6.84613386286599e-51 -2.24834899858951 2.16889870319697e-54 MirTarget -0.505609612406096 5.19553073856163e-50 NA NA NA hsa-miR-141-3p TGFB2 2.99777540204168 1.26370498493024e-78 -0.568239705690126 0.00206510120463672 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.201139839320628 1.72029232417547e-08 NA NA NA hsa-miR-200a-3p TGFB2 2.55218480823434 2.96135446816238e-51 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.157197308079383 7.61768751897913e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-200b-3p TGFBR1 2.11744072703209 1.66710572104191e-43 -0.276773756857041 0.00374479166499862 mirMAP -0.133382190063293 2.90573705377005e-11 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-let-7e-5p TGFBR3 0.261471269338985 0.00191077095550257 -3.32389218515653 1.82193869897655e-62 MirTarget -0.179320102086631 0.0423394482569628 NA NA NA hsa-miR-200b-3p THEMIS 2.11744072703209 1.66710572104191e-43 -0.694831838764676 0.000974328878154886 mirMAP -0.134705394978116 0.00263329809583339 NA NA NA hsa-miR-200c-3p THEMIS 2.07038651806183 6.84613386286599e-51 -0.694831838764676 0.000974328878154886 mirMAP -0.106515438271245 0.0307814013429153 NA NA NA hsa-miR-200b-3p THRA 2.11744072703209 1.66710572104191e-43 -1.02955320595519 1.31044247003034e-25 TargetScan;mirMAP -0.111191523388094 2.04291348368424e-07 NA NA NA hsa-miR-200c-3p THRA 2.07038651806183 6.84613386286599e-51 -1.02955320595519 1.31044247003034e-25 mirMAP -0.164553566630917 1.94353061935044e-12 NA NA NA hsa-miR-141-3p THRB 2.99777540204168 1.26370498493024e-78 -1.90956725674414 3.33207199356048e-40 MirTarget;TargetScan;miRNATAP -0.281746020368853 8.05412831431655e-23 NA NA NA hsa-miR-200a-3p THRB 2.55218480823434 2.96135446816238e-51 -1.90956725674414 3.33207199356048e-40 MirTarget;miRNATAP -0.216248963256199 2.81569538365581e-14 NA NA NA hsa-miR-200b-3p THRB 2.11744072703209 1.66710572104191e-43 -1.90956725674414 3.33207199356048e-40 TargetScan;mirMAP -0.197678692990186 5.08028621353357e-10 NA NA NA hsa-miR-28-5p THRB -0.14267073663385 0.0497619246260571 -1.90956725674414 3.33207199356048e-40 miRanda -0.27319149495517 0.000145463303643686 NA NA NA hsa-miR-132-3p THSD4 -0.0365213889238607 0.668598301088667 0.0741740305225802 0.740086284221452 MirTarget -0.24885518744268 0.00595984714885817 NA NA NA hsa-miR-141-3p THSD7A 2.99777540204168 1.26370498493024e-78 -1.80803008417679 7.98411384414828e-26 TargetScan -0.470041136915774 3.27174264298659e-47 NA NA NA hsa-miR-200b-3p THSD7A 2.11744072703209 1.66710572104191e-43 -1.80803008417679 7.98411384414828e-26 TargetScan -0.401053024783458 3.56656415289921e-28 NA NA NA hsa-miR-143-3p TIGD5 -1.23248181631499 4.74160976678504e-28 1.47420872442042 6.92359898976667e-39 MirTarget -0.216657727905615 4.68258631941854e-10 NA NA NA hsa-miR-28-5p TIMM17B -0.14267073663385 0.0497619246260571 1.26177930091032 3.653096676374e-45 miRanda -0.130289288298862 0.00383630002885173 NA NA NA hsa-miR-200b-3p TIMP2 2.11744072703209 1.66710572104191e-43 -0.790977606892998 7.91966411856086e-15 TargetScan -0.281885890717356 1.36324026240457e-41 23205572 A novel target of miR-200b tissue inhibitor of metalloproteinase 2 TIMP2 was predicted using a bioinformatics approach and was confirmed in human endometrial cancer cell line HEC-1A cells by luciferase assay quantitative real-time polymerase chain reaction western blotting and enzyme-linked immunosorbent assay; We found that miR-200b repressed TIMP2 expression at both the messenger RNA and protein levels although a family member miR-200a had no such effect; Using reverse gelatin zymography we showed that miR-200b enhances matrix metallopeptidase 2 MMP2 activity by downregulating TIMP2 expression in HEC-1A cells endometrial cancer hsa-miR-200c-3p TIMP2 2.07038651806183 6.84613386286599e-51 -0.790977606892998 7.91966411856086e-15 miRTarBase -0.348884866594025 7.49589633579639e-54 NA NA NA hsa-miR-200b-3p TJP1 2.11744072703209 1.66710572104191e-43 -0.765496503458334 3.43269584339806e-25 TargetScan -0.129222453934998 3.51217254190336e-16 NA NA NA hsa-miR-28-5p TK2 -0.14267073663385 0.0497619246260571 -0.945845591912347 8.82078867072266e-48 mirMAP -0.143827133461578 1.14353503977375e-05 NA NA NA hsa-miR-200b-3p TLN1 2.11744072703209 1.66710572104191e-43 -0.806997562437992 3.90911750864684e-41 TargetScan -0.16307330532858 3.45299485359747e-37 NA NA NA hsa-miR-200c-3p TLN1 2.07038651806183 6.84613386286599e-51 -0.806997562437992 3.90911750864684e-41 miRNATAP -0.211158596185854 6.01914896728009e-53 NA NA NA hsa-miR-141-3p TLN2 2.99777540204168 1.26370498493024e-78 -1.83784711672792 1.84067578710874e-73 TargetScan -0.364377427050569 7.04292918886026e-77 NA NA NA hsa-miR-200a-3p TLN2 2.55218480823434 2.96135446816238e-51 -1.83784711672792 1.84067578710874e-73 mirMAP -0.279655297923562 5.01589411621067e-44 NA NA NA hsa-miR-200b-3p TLN2 2.11744072703209 1.66710572104191e-43 -1.83784711672792 1.84067578710874e-73 TargetScan -0.290211927011083 5.65007406224696e-38 NA NA NA hsa-miR-200c-3p TLN2 2.07038651806183 6.84613386286599e-51 -1.83784711672792 1.84067578710874e-73 miRNATAP -0.398854834101476 5.91754554874285e-62 NA NA NA hsa-miR-28-5p TM9SF1 -0.14267073663385 0.0497619246260571 0.511606899292477 9.1955728473893e-18 miRanda -0.215783534058051 3.66881145727977e-14 NA NA NA hsa-miR-28-5p TMCO1 -0.14267073663385 0.0497619246260571 0.851360857509368 3.5933761176123e-38 miRanda -0.113140925721111 0.000567460927779503 NA NA NA hsa-miR-28-5p TMED3 -0.14267073663385 0.0497619246260571 1.5516937076501 5.27191563318331e-68 miRanda -0.161128244421002 0.000478744777849298 NA NA NA hsa-miR-141-3p TMEM108 2.99777540204168 1.26370498493024e-78 -0.580310191018694 0.00285718388503917 mirMAP -0.132320945372234 0.000471240582415183 NA NA NA hsa-miR-200a-3p TMEM108 2.55218480823434 2.96135446816238e-51 -0.580310191018694 0.00285718388503917 mirMAP -0.130766547323886 0.000427848538666159 NA NA NA hsa-miR-143-3p TMEM121 -1.23248181631499 4.74160976678504e-28 1.72477615972529 1.15425790033481e-25 MirTarget -0.207080400253365 3.63700518363714e-05 NA NA NA hsa-miR-28-5p TMEM127 -0.14267073663385 0.0497619246260571 0.174849740894885 1.63674596548421e-05 MirTarget -0.100245573572565 1.75236540208333e-07 NA NA NA hsa-miR-141-3p TMEM130 2.99777540204168 1.26370498493024e-78 -0.151401709333805 0.433770192378502 MirTarget;TargetScan -0.15529610707997 3.41284676746256e-05 NA NA NA hsa-miR-200a-3p TMEM130 2.55218480823434 2.96135446816238e-51 -0.151401709333805 0.433770192378502 MirTarget -0.141026223203448 0.00012663030238112 NA NA NA hsa-miR-141-3p TMEM135 2.99777540204168 1.26370498493024e-78 -0.662276560426261 1.65116614173733e-11 MirTarget;TargetScan -0.121638969831776 2.1777902714527e-10 NA NA NA hsa-miR-200a-3p TMEM135 2.55218480823434 2.96135446816238e-51 -0.662276560426261 1.65116614173733e-11 MirTarget -0.132409119844956 1.62565609138772e-12 NA NA NA hsa-miR-28-5p TMEM143 -0.14267073663385 0.0497619246260571 -0.466637204908091 3.9291975727201e-11 miRanda -0.213576348163273 2.24806769006338e-10 NA NA NA hsa-miR-28-5p TMEM144 -0.14267073663385 0.0497619246260571 -0.222974365100777 0.0453860472712897 miRanda -0.391648808451717 7.14375923521578e-14 NA NA NA hsa-miR-28-5p TMEM167A -0.14267073663385 0.0497619246260571 0.0809111072909596 0.146434441090959 MirTarget;miRanda -0.111664828448186 2.29709460466846e-05 NA NA NA hsa-miR-141-3p TMEM170B 2.99777540204168 1.26370498493024e-78 -1.50335449366583 7.54725989395169e-43 MirTarget;TargetScan;miRNATAP -0.262820919850681 3.52801180749301e-34 NA NA NA hsa-miR-200a-3p TMEM170B 2.55218480823434 2.96135446816238e-51 -1.50335449366583 7.54725989395169e-43 MirTarget;miRNATAP -0.240821801746225 1.07445943843933e-29 NA NA NA hsa-miR-200b-3p TMEM170B 2.11744072703209 1.66710572104191e-43 -1.50335449366583 7.54725989395169e-43 TargetScan -0.266180835867404 2.54867491574085e-29 NA NA NA hsa-miR-200c-3p TMEM170B 2.07038651806183 6.84613386286599e-51 -1.50335449366583 7.54725989395169e-43 miRNATAP -0.290974485300329 5.72219152421604e-29 NA NA NA hsa-miR-28-5p TMEM215 -0.14267073663385 0.0497619246260571 2.65768345418265 2.3521799065528e-20 miRanda -0.555439357324754 7.2589393236591e-05 NA NA NA hsa-miR-28-5p TMEM229B -0.14267073663385 0.0497619246260571 0.727265089473085 3.07635214377309e-08 miRanda -0.429646253572464 5.46749176294498e-12 NA NA NA hsa-miR-200b-3p TMEM43 2.11744072703209 1.66710572104191e-43 -0.763185893816313 4.24636950864574e-43 MirTarget -0.130572977271474 1.24927813264347e-27 NA NA NA hsa-miR-200c-3p TMEM43 2.07038651806183 6.84613386286599e-51 -0.763185893816313 4.24636950864574e-43 MirTarget -0.155461686323236 1.7017036656773e-32 NA NA NA hsa-miR-200b-3p TMEM56 2.11744072703209 1.66710572104191e-43 -0.879067538548105 5.53435751506619e-08 MirTarget -0.115622202652343 0.00081987693642058 NA NA NA hsa-miR-200c-3p TMEM56 2.07038651806183 6.84613386286599e-51 -0.879067538548105 5.53435751506619e-08 MirTarget -0.154954841586415 4.41688879430918e-05 NA NA NA hsa-miR-143-3p TMEM69 -1.23248181631499 4.74160976678504e-28 0.271733459624416 4.97949383880418e-07 MirTarget -0.102367544601439 1.18681600521911e-10 NA NA NA hsa-miR-28-5p TMEM9 -0.14267073663385 0.0497619246260571 1.17225854097205 9.42118512805465e-50 miRanda -0.122673788326945 0.00217777126125373 NA NA NA hsa-miR-28-5p TMPRSS4 -0.14267073663385 0.0497619246260571 3.35879061803581 9.9015112131537e-20 miRanda -0.503325088395346 0.00522533815614918 NA NA NA hsa-miR-28-5p TMUB1 -0.14267073663385 0.0497619246260571 1.12105172023654 7.11663811953612e-29 miRanda;miRNATAP -0.152750765888196 0.00205613729174163 NA NA NA hsa-let-7e-5p TNFAIP3 0.261471269338985 0.00191077095550257 -0.384684183147111 0.000748234816409438 miRNATAP -0.191802534283467 3.92788576759362e-05 NA NA NA hsa-miR-141-3p TNFAIP3 2.99777540204168 1.26370498493024e-78 -0.384684183147111 0.000748234816409438 TargetScan -0.132297814865696 1.95395162655108e-09 NA NA NA hsa-miR-200c-3p TNFRSF11B 2.07038651806183 6.84613386286599e-51 -0.837140585338879 5.84752838227966e-05 miRNATAP -0.223884434938994 4.07830474922777e-06 NA NA NA hsa-let-7e-5p TNFRSF1B 0.261471269338985 0.00191077095550257 -0.843214002710789 3.37305069739693e-14 MirTarget;miRNATAP -0.187965239756623 4.52106977887276e-05 NA NA NA hsa-miR-28-5p TNK1 -0.14267073663385 0.0497619246260571 0.739466980555803 1.02517411574197e-12 miRanda -0.320837899015955 9.84933977086471e-11 NA NA NA hsa-let-7e-5p TNNI1 0.261471269338985 0.00191077095550257 -0.176981917690524 0.412598510037109 mirMAP -0.353616599315608 5.97507707671368e-05 NA NA NA hsa-miR-141-3p TNS1 2.99777540204168 1.26370498493024e-78 -2.87283202537718 5.47225880201927e-123 MirTarget;TargetScan -0.547321395184938 4.63833445319417e-116 NA NA NA hsa-miR-200a-3p TNS1 2.55218480823434 2.96135446816238e-51 -2.87283202537718 5.47225880201927e-123 MirTarget -0.446329981211595 1.07949671448638e-72 NA NA NA hsa-miR-141-3p TNS3 2.99777540204168 1.26370498493024e-78 -0.350351470632321 2.83318833184234e-05 MirTarget;TargetScan;miRNATAP -0.154380749259515 2.96503581653606e-22 NA NA NA hsa-miR-200a-3p TNS3 2.55218480823434 2.96135446816238e-51 -0.350351470632321 2.83318833184234e-05 MirTarget;miRNATAP -0.146180367593977 9.19956142945461e-21 NA NA NA hsa-miR-28-5p TOM1L1 -0.14267073663385 0.0497619246260571 0.704932194727521 7.70954564884351e-09 miRanda -0.356251331334049 8.93759550117042e-10 NA NA NA hsa-miR-141-3p TOM1L2 2.99777540204168 1.26370498493024e-78 -0.520667499227671 1.47555060196936e-09 TargetScan;miRNATAP -0.102869378558876 7.97330711179155e-10 NA NA NA hsa-miR-28-5p TOM1L2 -0.14267073663385 0.0497619246260571 -0.520667499227671 1.47555060196936e-09 mirMAP -0.302979441496192 1.13329564543543e-13 NA NA NA hsa-miR-143-3p TOR2A -1.23248181631499 4.74160976678504e-28 1.23710419305096 1.78961795509186e-50 mirMAP -0.206803411118702 7.54121110441846e-16 NA NA NA hsa-miR-28-5p TOX3 -0.14267073663385 0.0497619246260571 1.00432770054387 0.00104894619135282 miRanda -0.896029443840828 6.53496646773437e-10 NA NA NA hsa-miR-28-5p TP53I11 -0.14267073663385 0.0497619246260571 0.760507593043101 2.5492467701477e-19 mirMAP -0.230580358591439 1.73546703985814e-08 NA NA NA hsa-miR-143-3p TP53RK -1.23248181631499 4.74160976678504e-28 0.518677505417969 2.09006365521444e-21 MirTarget -0.122238593229477 6.2388984226521e-14 NA NA NA hsa-miR-141-3p TP63 2.99777540204168 1.26370498493024e-78 -3.22723602151797 5.78415028904247e-31 MirTarget -0.491288946265715 5.34967525764489e-19 NA NA NA hsa-miR-200a-3p TP63 2.55218480823434 2.96135446816238e-51 -3.22723602151797 5.78415028904247e-31 MirTarget -0.353907219678474 9.99717457803129e-11 NA NA NA hsa-let-7e-5p TPK1 0.261471269338985 0.00191077095550257 -0.660638989360007 2.1840044828043e-14 MirTarget -0.125941383628773 0.00044675963930344 NA NA NA hsa-miR-143-3p TPM3 -1.23248181631499 4.74160976678504e-28 1.20094351262857 1.52351376875333e-75 miRNATAP -0.193288420056246 1.18393017970237e-20 NA NA NA hsa-miR-145-5p TPM3 -2.62703571936687 7.64402900188551e-88 1.20094351262857 1.52351376875333e-75 miRNAWalker2_validate -0.199366546874454 8.34701725003177e-36 NA NA NA hsa-miR-28-5p TPPP -0.14267073663385 0.0497619246260571 -1.92877951837205 2.92993881764168e-28 mirMAP -0.346777324895735 5.5972293149967e-05 NA NA NA hsa-miR-141-3p TRAM2 2.99777540204168 1.26370498493024e-78 -0.321344955137462 8.52325476310052e-06 MirTarget;TargetScan -0.138490815513452 4.89595532123783e-24 NA NA NA hsa-miR-200a-3p TRAM2 2.55218480823434 2.96135446816238e-51 -0.321344955137462 8.52325476310052e-06 MirTarget -0.136256145024944 3.59086277571307e-24 NA NA NA hsa-miR-141-3p TRHDE 2.99777540204168 1.26370498493024e-78 -4.5651188211774 8.96847933550376e-61 MirTarget;TargetScan -0.882210380275507 9.37283822162336e-60 NA NA NA hsa-miR-200a-3p TRHDE 2.55218480823434 2.96135446816238e-51 -4.5651188211774 8.96847933550376e-61 MirTarget -0.72223464669766 3.84608591210662e-40 NA NA NA hsa-miR-200b-3p TRHDE 2.11744072703209 1.66710572104191e-43 -4.5651188211774 8.96847933550376e-61 MirTarget;TargetScan -0.765884739281711 2.68804356035911e-36 NA NA NA hsa-miR-200c-3p TRHDE 2.07038651806183 6.84613386286599e-51 -4.5651188211774 8.96847933550376e-61 MirTarget -0.969820580794507 4.01275370688948e-49 NA NA NA hsa-miR-200b-3p TRIM2 2.11744072703209 1.66710572104191e-43 -1.82935991153139 3.44821085419053e-31 TargetScan -0.104488794967568 0.00260578116286237 NA NA NA hsa-miR-200c-3p TRIM2 2.07038651806183 6.84613386286599e-51 -1.82935991153139 3.44821085419053e-31 miRNATAP -0.160922462014355 2.36103337148741e-05 NA NA NA hsa-miR-132-3p TRIM23 -0.0365213889238607 0.668598301088667 -0.683201005926275 2.66644008303317e-19 miRNAWalker2_validate -0.113726078056972 0.000295292870797658 NA NA NA hsa-miR-141-3p TRIM23 2.99777540204168 1.26370498493024e-78 -0.683201005926275 2.66644008303317e-19 MirTarget;TargetScan -0.12175947507209 2.3657294160518e-16 NA NA NA hsa-miR-200a-3p TRIM23 2.55218480823434 2.96135446816238e-51 -0.683201005926275 2.66644008303317e-19 MirTarget -0.107190333023802 2.29198715725505e-13 NA NA NA hsa-miR-200b-3p TRIM23 2.11744072703209 1.66710572104191e-43 -0.683201005926275 2.66644008303317e-19 MirTarget -0.111884543453949 6.590547797904e-12 NA NA NA hsa-miR-200c-3p TRIM23 2.07038651806183 6.84613386286599e-51 -0.683201005926275 2.66644008303317e-19 MirTarget -0.132015163835771 1.54228785996194e-13 NA NA NA hsa-miR-28-5p TRIM23 -0.14267073663385 0.0497619246260571 -0.683201005926275 2.66644008303317e-19 MirTarget;miRanda -0.24115237133317 4.6089734472748e-11 NA NA NA hsa-let-7e-5p TRPM6 0.261471269338985 0.00191077095550257 -3.03043627803069 1.81297760239146e-38 miRNATAP -0.290647906212123 0.00375087437442479 NA NA NA hsa-miR-143-3p TRPS1 -1.23248181631499 4.74160976678504e-28 0.975779250773293 1.00018911688075e-11 miRNATAP -0.2861157765478 1.66201091679034e-11 NA NA NA hsa-miR-28-5p TRPS1 -0.14267073663385 0.0497619246260571 0.975779250773293 1.00018911688075e-11 PITA;miRanda;miRNATAP -0.141435859063669 0.0410592316645809 NA NA NA hsa-miR-200b-3p TRPV3 2.11744072703209 1.66710572104191e-43 -1.18143944497478 1.90717583464061e-06 TargetScan -0.183113194318092 0.000533202771102452 NA NA NA hsa-miR-200c-3p TRPV3 2.07038651806183 6.84613386286599e-51 -1.18143944497478 1.90717583464061e-06 miRNATAP -0.161039585811955 0.00566754695485503 NA NA NA hsa-miR-28-5p TRUB2 -0.14267073663385 0.0497619246260571 0.674503131886807 1.91964910840085e-28 miRanda -0.167148321435792 2.03074836591556e-08 NA NA NA hsa-miR-200b-3p TSC22D1 2.11744072703209 1.66710572104191e-43 -0.769265226283634 1.08321730787095e-26 MirTarget;TargetScan -0.102611273301241 4.4511352619003e-11 NA NA NA hsa-miR-200c-3p TSC22D1 2.07038651806183 6.84613386286599e-51 -0.769265226283634 1.08321730787095e-26 MirTarget;miRNATAP -0.116865872245542 8.49008322011176e-12 NA NA NA hsa-miR-132-3p TSC22D3 -0.0365213889238607 0.668598301088667 -0.54824265518886 3.00229686619098e-07 miRNATAP -0.132685575865446 0.00233602360672125 NA NA NA hsa-miR-28-5p TSG101 -0.14267073663385 0.0497619246260571 0.296712396871171 9.16329380962956e-09 miRanda -0.151996263076067 5.58777477793531e-10 NA NA NA hsa-miR-141-3p TSHZ3 2.99777540204168 1.26370498493024e-78 -0.73282959487018 6.60562399903423e-11 MirTarget;TargetScan;miRNATAP -0.283434224716805 1.27966555313161e-41 NA NA NA hsa-miR-200a-3p TSHZ3 2.55218480823434 2.96135446816238e-51 -0.73282959487018 6.60562399903423e-11 MirTarget;miRNATAP -0.241748570999405 4.78092529696568e-31 NA NA NA hsa-miR-28-5p TSNAX -0.14267073663385 0.0497619246260571 0.422819928987759 7.41936878269938e-12 miRanda -0.124763553794833 2.54924890571281e-05 NA NA NA hsa-miR-143-3p TSPAN13 -1.23248181631499 4.74160976678504e-28 1.32666855210058 2.66661158082269e-24 miRNATAP -0.326630510091675 5.76217474385877e-17 NA NA NA hsa-miR-141-3p TSPAN4 2.99777540204168 1.26370498493024e-78 -0.587112707496993 4.37105941580206e-09 TargetScan -0.190772972993814 1.64489959254982e-23 NA NA NA hsa-miR-141-3p TTBK2 2.99777540204168 1.26370498493024e-78 -1.51507396028917 3.2070875074631e-25 MirTarget -0.266335225275997 1.2345387718611e-20 NA NA NA hsa-miR-200a-3p TTBK2 2.55218480823434 2.96135446816238e-51 -1.51507396028917 3.2070875074631e-25 MirTarget -0.238406608015847 2.66957487030803e-17 NA NA NA hsa-miR-28-5p TTC25 -0.14267073663385 0.0497619246260571 0.0268474985965776 0.854483881724695 miRanda -0.246590592818799 0.000393070449956777 NA NA NA hsa-miR-141-3p TTC28 2.99777540204168 1.26370498493024e-78 -1.65844116125173 3.58098324297455e-63 TargetScan -0.340842707295731 7.89989938927947e-72 NA NA NA hsa-miR-200b-3p TTC33 2.11744072703209 1.66710572104191e-43 -0.816894102497242 8.42479956181868e-34 TargetScan -0.111694926392745 2.62082778940452e-14 NA NA NA hsa-miR-28-5p TTC39A -0.14267073663385 0.0497619246260571 1.75127730029576 1.95458566556964e-23 miRanda -0.561215658602864 4.32187154676238e-11 NA NA NA hsa-miR-28-5p TTC39C -0.14267073663385 0.0497619246260571 0.148888218233073 0.119005357502186 miRanda -0.238856584253465 1.2467565465088e-07 NA NA NA hsa-miR-28-5p TTC8 -0.14267073663385 0.0497619246260571 0.178398576559903 0.035079271986482 miRanda -0.380737846963701 3.34153417132127e-22 NA NA NA hsa-let-7e-5p TTLL4 0.261471269338985 0.00191077095550257 0.225675037837154 0.0264033481456552 MirTarget;miRNATAP -0.1098980480549 0.00822834167666414 NA NA NA hsa-miR-141-3p TTLL7 2.99777540204168 1.26370498493024e-78 -1.14660093900781 4.12921497375204e-09 MirTarget;TargetScan -0.239965832625743 2.45594828259806e-10 NA NA NA hsa-miR-200a-3p TTLL7 2.55218480823434 2.96135446816238e-51 -1.14660093900781 4.12921497375204e-09 MirTarget -0.219896502995049 3.56866012725551e-09 NA NA NA hsa-miR-141-3p TTYH2 2.99777540204168 1.26370498493024e-78 -0.651069390632769 1.95664259540559e-09 TargetScan;miRNATAP -0.161556429800192 1.29736653314157e-14 NA NA NA hsa-miR-200a-3p TTYH2 2.55218480823434 2.96135446816238e-51 -0.651069390632769 1.95664259540559e-09 miRNATAP -0.164568131662886 1.12630590978141e-15 NA NA NA hsa-miR-200c-3p TUBB2A 2.07038651806183 6.84613386286599e-51 -0.593966447842469 2.37131788141525e-07 MirTarget;miRNATAP -0.162306818074891 1.3159105360671e-09 NA NA NA hsa-miR-28-5p TUBGCP5 -0.14267073663385 0.0497619246260571 -0.192566353644787 0.00132433306189554 miRanda -0.107054440107932 0.000173050564531711 NA NA NA hsa-miR-28-5p TUFM -0.14267073663385 0.0497619246260571 0.727504297935931 6.51865293930577e-27 miRNAWalker2_validate -0.163308818860107 8.17892052902472e-07 NA NA NA hsa-miR-28-5p TXNDC15 -0.14267073663385 0.0497619246260571 -0.12678933462949 0.0100887464640449 miRanda -0.106882127419917 4.56302344280308e-06 NA NA NA hsa-miR-141-3p TXNIP 2.99777540204168 1.26370498493024e-78 -2.1278383158488 8.14661112419651e-76 MirTarget -0.370028098915553 2.38007344541804e-58 NA NA NA hsa-miR-200a-3p TXNIP 2.55218480823434 2.96135446816238e-51 -2.1278383158488 8.14661112419651e-76 MirTarget -0.277572731123545 1.06886008509125e-32 NA NA NA hsa-miR-141-3p UACA 2.99777540204168 1.26370498493024e-78 -0.950369501657328 4.25857257062218e-39 TargetScan -0.185553686719098 1.80726170106575e-39 NA NA NA hsa-miR-28-5p UBE2Z -0.14267073663385 0.0497619246260571 0.531416701885103 1.79902342102429e-16 PITA;miRanda -0.126906932637718 4.71304832612847e-05 NA NA NA hsa-miR-28-5p UBE3B -0.14267073663385 0.0497619246260571 -0.04341053843455 0.44320588192684 miRanda -0.20876431830344 2.90771228545953e-15 NA NA NA hsa-miR-28-5p UBTD2 -0.14267073663385 0.0497619246260571 0.128941566560699 0.0252656180967694 MirTarget;miRanda -0.113783835802965 3.10751419447168e-05 NA NA NA hsa-miR-28-5p UBTF -0.14267073663385 0.0497619246260571 0.480221215287978 7.43410138383196e-26 miRanda -0.110317015872406 7.05826550992748e-07 NA NA NA hsa-miR-143-3p UBXN2B -1.23248181631499 4.74160976678504e-28 0.33494906400209 2.06319545781576e-05 MirTarget -0.124646942349979 7.8590762950058e-08 NA NA NA hsa-miR-200b-3p UBXN7 2.11744072703209 1.66710572104191e-43 -0.613443672996766 2.02580451264322e-07 TargetScan;mirMAP -0.103286193982759 3.98531227124601e-05 NA NA NA hsa-miR-28-5p ULK3 -0.14267073663385 0.0497619246260571 0.735573512973171 1.0601693976613e-25 miRanda -0.126486106001449 0.000233852849670499 NA NA NA hsa-miR-145-5p UNC13A -2.62703571936687 7.64402900188551e-88 1.98359819710959 1.82329897801348e-18 mirMAP -0.251467798441492 2.58963752109121e-06 NA NA NA hsa-let-7e-5p UNC5A 0.261471269338985 0.00191077095550257 1.33329435166571 1.82788906067336e-06 mirMAP -0.373557990186031 0.00115022962187532 NA NA NA hsa-miR-28-5p UNC5A -0.14267073663385 0.0497619246260571 1.33329435166571 1.82788906067336e-06 miRNATAP -0.712227331995954 8.73537148083903e-08 NA NA NA hsa-miR-141-3p UNC5C 2.99777540204168 1.26370498493024e-78 -1.39702927654382 2.18325905910281e-12 MirTarget;TargetScan -0.303226133260993 3.93037191707908e-15 NA NA NA hsa-miR-200a-3p UNC5C 2.55218480823434 2.96135446816238e-51 -1.39702927654382 2.18325905910281e-12 MirTarget -0.246863233283842 9.03019066185357e-11 NA NA NA hsa-miR-28-5p URGCP -0.14267073663385 0.0497619246260571 0.0526536004239073 0.285595768643589 MirTarget;miRanda;miRNATAP -0.148657531101123 1.3587095350023e-10 NA NA NA hsa-miR-28-5p URM1 -0.14267073663385 0.0497619246260571 0.389004206411093 5.19312203313837e-12 miRanda -0.102999514913133 0.000142527195319968 NA NA NA hsa-miR-132-3p USP38 -0.0365213889238607 0.668598301088667 0.129025166125443 0.0698742530527362 MirTarget -0.107306393563697 0.000187361219034562 NA NA NA hsa-miR-141-3p USP53 2.99777540204168 1.26370498493024e-78 -1.49116967272135 3.36605167840143e-42 TargetScan -0.211991882585796 3.39646673159852e-22 NA NA NA hsa-miR-28-5p VAMP2 -0.14267073663385 0.0497619246260571 -0.910984420288792 2.5523112591877e-32 PITA;miRNATAP -0.159632481053742 2.65737741521612e-05 NA NA NA hsa-miR-200c-3p VASH1 2.07038651806183 6.84613386286599e-51 -0.0383472405570258 0.657089178226667 MirTarget;miRNATAP -0.144847192398297 2.90101239756295e-13 NA NA NA hsa-miR-200b-3p VAT1L 2.11744072703209 1.66710572104191e-43 -1.42983088580135 2.75386157340812e-14 MirTarget;TargetScan -0.303491736681768 2.90408835363678e-14 NA NA NA hsa-miR-200c-3p VAT1L 2.07038651806183 6.84613386286599e-51 -1.42983088580135 2.75386157340812e-14 MirTarget;miRNATAP -0.399013122726224 5.23239500429498e-20 NA NA NA hsa-miR-28-5p VAV3 -0.14267073663385 0.0497619246260571 1.34411719441904 1.087241773222e-13 miRanda -0.611662799107083 1.47436473807405e-12 NA NA NA hsa-miR-200a-3p VCAM1 2.55218480823434 2.96135446816238e-51 -0.422080444805657 0.00361929851720551 miRNAWalker2_validate -0.192217611764734 2.18432689837879e-12 NA NA NA hsa-miR-200a-3p VCAN 2.55218480823434 2.96135446816238e-51 1.40978286772495 4.56459858126373e-18 MirTarget;miRNATAP -0.114795253898198 0.000286385738872126 NA NA NA hsa-miR-28-5p VEZF1 -0.14267073663385 0.0497619246260571 -0.218442006456705 0.0044599756979924 miRanda -0.163030520501413 7.78947500099617e-06 NA NA NA hsa-miR-28-5p VEZT -0.14267073663385 0.0497619246260571 0.181406259391838 0.0056683713856385 MirTarget;miRanda -0.148894796889565 1.6576465295747e-06 NA NA NA hsa-miR-200b-3p VGLL3 2.11744072703209 1.66710572104191e-43 -2.09691663808755 1.44457964531322e-38 mirMAP -0.405161046893378 1.16996761884778e-31 NA NA NA hsa-miR-200c-3p VGLL3 2.07038651806183 6.84613386286599e-51 -2.09691663808755 1.44457964531322e-38 mirMAP -0.489399000934698 1.6719482694344e-38 NA NA NA hsa-miR-200b-3p VLDLR 2.11744072703209 1.66710572104191e-43 -1.77227581372422 1.67512075345855e-32 TargetScan -0.314691879127484 1.17172322744022e-22 NA NA NA hsa-miR-200c-3p VLDLR 2.07038651806183 6.84613386286599e-51 -1.77227581372422 1.67512075345855e-32 miRNATAP -0.363293932443391 6.00658962928933e-25 NA NA NA hsa-miR-28-5p VPS16 -0.14267073663385 0.0497619246260571 0.602929299080128 4.52608838781167e-22 miRNATAP -0.158580378621744 1.64596827431613e-07 NA NA NA hsa-let-7e-5p VSNL1 0.261471269338985 0.00191077095550257 -1.16811921852226 1.22536881204956e-07 miRNATAP -0.303997999468258 0.000827886452121201 NA NA NA hsa-miR-28-5p VWA3A -0.14267073663385 0.0497619246260571 0.383442103163063 0.125108467711998 miRanda -0.365623168031948 0.00213064702838744 NA NA NA hsa-miR-200b-3p WASF1 2.11744072703209 1.66710572104191e-43 -0.678475233936717 7.60607099773565e-07 TargetScan -0.154713851640072 1.06487816140692e-07 NA NA NA hsa-miR-200c-3p WASF1 2.07038651806183 6.84613386286599e-51 -0.678475233936717 7.60607099773565e-07 miRNATAP -0.128457054878815 6.36546774218895e-05 NA NA NA hsa-miR-200a-3p WASF3 2.55218480823434 2.96135446816238e-51 -2.52846175739233 2.89361416346383e-58 miRNAWalker2_validate;miRTarBase -0.405908608720436 7.8748305448137e-40 NA NA NA hsa-miR-200b-3p WASF3 2.11744072703209 1.66710572104191e-43 -2.52846175739233 2.89361416346383e-58 miRNAWalker2_validate;miRTarBase;TargetScan -0.426347852136764 2.62441563344211e-35 NA NA NA hsa-miR-200c-3p WASF3 2.07038651806183 6.84613386286599e-51 -2.52846175739233 2.89361416346383e-58 miRNATAP -0.459350727713875 7.74115548172737e-34 NA NA NA hsa-miR-28-5p WBP1 -0.14267073663385 0.0497619246260571 0.580480433955926 7.12747644898469e-17 miRanda -0.227493317147737 9.00615701119687e-12 NA NA NA hsa-miR-141-3p WDFY4 2.99777540204168 1.26370498493024e-78 0.363624047287499 0.0168187084939681 mirMAP -0.107769926345185 0.000264327137473322 NA NA NA hsa-miR-28-5p WDR83 -0.14267073663385 0.0497619246260571 0.79199972757636 1.67453700958747e-15 miRanda -0.229298714039308 1.76029336904606e-06 NA NA NA hsa-miR-141-3p WIPF1 2.99777540204168 1.26370498493024e-78 -0.259862115966063 0.00927399244683076 MirTarget;TargetScan;miRNATAP -0.182826846335189 4.90344827226961e-22 NA NA NA hsa-miR-200a-3p WIPF1 2.55218480823434 2.96135446816238e-51 -0.259862115966063 0.00927399244683076 MirTarget;miRNATAP -0.168234298344575 1.8780051849382e-19 NA NA NA hsa-miR-200b-3p WIPF1 2.11744072703209 1.66710572104191e-43 -0.259862115966063 0.00927399244683076 MirTarget;TargetScan -0.191286536551454 2.66416174733952e-20 NA NA NA hsa-miR-200c-3p WIPF1 2.07038651806183 6.84613386286599e-51 -0.259862115966063 0.00927399244683076 MirTarget;miRNATAP -0.214983608550577 3.51466280882004e-21 NA NA NA hsa-miR-28-5p WIPF2 -0.14267073663385 0.0497619246260571 -0.00735809585132774 0.937520602697966 MirTarget;miRanda;miRNATAP -0.134513318957187 0.00257432351610525 NA NA NA hsa-miR-200a-3p WNK3 2.55218480823434 2.96135446816238e-51 -1.22066858615062 3.01056061938594e-09 mirMAP -0.106464900309189 0.00723468109119119 NA NA NA hsa-miR-141-3p WNT5A 2.99777540204168 1.26370498493024e-78 -0.0987969676790623 0.559050375624812 TargetScan -0.139214845204003 2.12785375749739e-05 NA NA NA hsa-miR-28-5p WNT9A -0.14267073663385 0.0497619246260571 0.447765230183606 0.0124427267373267 mirMAP -0.292797790744078 0.000600350405048975 NA NA NA hsa-miR-141-3p WTIP 2.99777540204168 1.26370498493024e-78 -0.673697271502645 8.0399213972999e-08 mirMAP -0.225708945128347 5.44689065635373e-21 NA NA NA hsa-miR-200a-3p WTIP 2.55218480823434 2.96135446816238e-51 -0.673697271502645 8.0399213972999e-08 mirMAP -0.153578019023446 1.2728190646307e-10 NA NA NA hsa-miR-141-3p WWC2 2.99777540204168 1.26370498493024e-78 -0.909757247991017 3.54549072341367e-12 mirMAP -0.227020947819862 2.22048189774092e-19 NA NA NA hsa-miR-200a-3p WWC2 2.55218480823434 2.96135446816238e-51 -0.909757247991017 3.54549072341367e-12 mirMAP -0.196388107244229 2.92794464455906e-15 NA NA NA hsa-miR-141-3p WWTR1 2.99777540204168 1.26370498493024e-78 -0.946157092633412 9.0126903364314e-15 MirTarget;TargetScan;miRNATAP -0.183547997043091 1.1010774322509e-14 NA NA NA hsa-miR-200a-3p WWTR1 2.55218480823434 2.96135446816238e-51 -0.946157092633412 9.0126903364314e-15 MirTarget;miRNATAP -0.182565021897447 4.59067387987806e-15 NA NA NA hsa-miR-200b-3p XG 2.11744072703209 1.66710572104191e-43 -1.55383315404176 7.05287200308045e-18 MirTarget -0.355395373239176 1.30097802792361e-20 NA NA NA hsa-miR-200c-3p XG 2.07038651806183 6.84613386286599e-51 -1.55383315404176 7.05287200308045e-18 MirTarget -0.42057390275489 8.34040723588348e-24 NA NA NA hsa-miR-143-3p XPO5 -1.23248181631499 4.74160976678504e-28 0.683411153594167 8.44851771608649e-19 MirTarget -0.141262556771914 9.98718020290809e-10 NA NA NA hsa-miR-141-3p YAP1 2.99777540204168 1.26370498493024e-78 -1.31738265371239 9.58372053397518e-43 MirTarget;TargetScan -0.224844503629252 1.84225185456191e-32 21289630 MicroRNA 141 confers resistance to cisplatin induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma; Furthermore we found that miR-141 directly targeted the 3'-untranslated region of YAP1 which is known to have a crucial role in apoptosis induced by DNA-damaging agents and thus downregulated YAP1 expression drug resistance esophageal cancer hsa-miR-200a-3p YAP1 2.55218480823434 2.96135446816238e-51 -1.31738265371239 9.58372053397518e-43 miRNAWalker2_validate;MirTarget -0.179180498954883 2.18192480130206e-21 23340296 MicroRNA 200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer; We identified Yes-associated protein 1 YAP1 as a novel target of miR-200a; Our data showed that targeting of YAP1 by miR-200a resulted in decreased expression of proapoptotic proteins which leads to anoikis resistance; Remarkably we found that YAP1 expression was inversely correlated with miR-200a expression in breast cancer clinical specimens and miR-200a expression was associated with distant metastasis in patients with breast cancer metastasis;drug resistance breast cancer hsa-miR-200b-3p YAP1 2.11744072703209 1.66710572104191e-43 -1.31738265371239 9.58372053397518e-43 MirTarget -0.192196263932001 6.22401511406624e-20 NA NA NA hsa-miR-200c-3p YAP1 2.07038651806183 6.84613386286599e-51 -1.31738265371239 9.58372053397518e-43 MirTarget -0.246914816784172 4.26453849203752e-27 NA NA NA hsa-let-7e-5p YOD1 0.261471269338985 0.00191077095550257 -0.0336871095417326 0.777311276662658 MirTarget;miRNATAP -0.109550900641532 0.0244943645606312 NA NA NA hsa-miR-200b-3p YPEL2 2.11744072703209 1.66710572104191e-43 -0.531843694095341 3.20174565714011e-08 TargetScan -0.112985153524515 3.12055418281865e-08 NA NA NA hsa-miR-200c-3p YPEL2 2.07038651806183 6.84613386286599e-51 -0.531843694095341 3.20174565714011e-08 miRNATAP -0.147767221733321 3.90405614738872e-11 NA NA NA hsa-miR-28-5p YPEL3 -0.14267073663385 0.0497619246260571 0.00907921639306331 0.92452046690186 MirTarget;PITA;miRanda -0.197612504863076 1.35986130569366e-05 NA NA NA hsa-miR-200b-3p YWHAG 2.11744072703209 1.66710572104191e-43 -0.30496627096666 3.16855379814272e-06 MirTarget;TargetScan -0.11952750278469 2.04909339347489e-18 NA NA NA hsa-miR-200c-3p YWHAG 2.07038651806183 6.84613386286599e-51 -0.30496627096666 3.16855379814272e-06 MirTarget;miRNATAP -0.115098762293347 2.44122702999837e-14 NA NA NA hsa-miR-141-3p ZBED3 2.99777540204168 1.26370498493024e-78 -1.03544978166773 5.82584960514108e-21 mirMAP -0.171544846006012 2.03628726726465e-15 NA NA NA hsa-miR-200a-3p ZBED3 2.55218480823434 2.96135446816238e-51 -1.03544978166773 5.82584960514108e-21 mirMAP -0.163383673828219 1.3753615171095e-14 NA NA NA hsa-miR-200a-3p ZBTB10 2.55218480823434 2.96135446816238e-51 -0.611029416368402 8.44024410685276e-06 mirMAP -0.134738385366774 2.56320263015494e-07 NA NA NA hsa-miR-200b-3p ZBTB10 2.11744072703209 1.66710572104191e-43 -0.611029416368402 8.44024410685276e-06 MirTarget -0.124716276670106 1.88539267361412e-05 NA NA NA hsa-miR-141-3p ZBTB16 2.99777540204168 1.26370498493024e-78 -4.63985301217587 2.47816545143769e-48 TargetScan -0.858851285229463 2.62803662236148e-43 NA NA NA hsa-miR-200b-3p ZBTB16 2.11744072703209 1.66710572104191e-43 -4.63985301217587 2.47816545143769e-48 TargetScan -0.662341942072399 2.71948254848324e-21 NA NA NA hsa-miR-141-3p ZBTB20 2.99777540204168 1.26370498493024e-78 -1.72085519412909 2.5148540758039e-32 MirTarget;TargetScan -0.289077227294819 5.29009513839861e-24 NA NA NA hsa-miR-200a-3p ZBTB20 2.55218480823434 2.96135446816238e-51 -1.72085519412909 2.5148540758039e-32 MirTarget -0.241363570116639 1.51792306924559e-17 NA NA NA hsa-miR-200b-3p ZBTB20 2.11744072703209 1.66710572104191e-43 -1.72085519412909 2.5148540758039e-32 TargetScan -0.244254584375419 1.092445337669e-14 NA NA NA hsa-miR-132-3p ZBTB34 -0.0365213889238607 0.668598301088667 -0.440834611575573 2.93634663899464e-13 mirMAP -0.106602316026011 1.57603126886836e-05 NA NA NA hsa-miR-200b-3p ZBTB38 2.11744072703209 1.66710572104191e-43 -0.896891924711862 1.92458588029593e-26 TargetScan -0.122629940797949 1.7968915362846e-11 NA NA NA hsa-miR-200b-3p ZC3H12B 2.11744072703209 1.66710572104191e-43 -1.71800694666271 1.87602247508669e-49 mirMAP -0.240916484226689 5.1761566883771e-21 NA NA NA hsa-miR-200c-3p ZC3H12B 2.07038651806183 6.84613386286599e-51 -1.71800694666271 1.87602247508669e-49 mirMAP -0.261786630015696 1.56794712673725e-20 NA NA NA hsa-miR-141-3p ZC3H12C 2.99777540204168 1.26370498493024e-78 -1.86703657263613 2.43378212227188e-45 MirTarget -0.282180972071193 9.13175461753934e-27 NA NA NA hsa-miR-200a-3p ZC3H12C 2.55218480823434 2.96135446816238e-51 -1.86703657263613 2.43378212227188e-45 MirTarget -0.250416624606868 6.22098001861092e-22 NA NA NA hsa-miR-200b-3p ZC3H12C 2.11744072703209 1.66710572104191e-43 -1.86703657263613 2.43378212227188e-45 TargetScan -0.283620764916226 9.95006759158569e-23 NA NA NA hsa-miR-200c-3p ZC3H12C 2.07038651806183 6.84613386286599e-51 -1.86703657263613 2.43378212227188e-45 miRNATAP -0.313872433644132 5.14238456112056e-23 NA NA NA hsa-miR-145-5p ZC3H3 -2.62703571936687 7.64402900188551e-88 1.00966545791486 6.06487089619898e-39 MirTarget -0.247741544891831 9.23230639398146e-44 NA NA NA hsa-miR-141-3p ZC3H6 2.99777540204168 1.26370498493024e-78 -0.90118202780819 2.98269815664226e-29 mirMAP -0.114199857389598 8.06442824583304e-13 NA NA NA hsa-miR-200c-3p ZC3H6 2.07038651806183 6.84613386286599e-51 -0.90118202780819 2.98269815664226e-29 MirTarget;miRNATAP -0.111431462921858 6.9471410147556e-09 NA NA NA hsa-miR-141-3p ZCCHC24 2.99777540204168 1.26370498493024e-78 -1.58022302811898 5.17246192367e-42 MirTarget;TargetScan;miRNATAP -0.436172356007355 3.12974751241543e-94 NA NA NA hsa-miR-200a-3p ZCCHC24 2.55218480823434 2.96135446816238e-51 -1.58022302811898 5.17246192367e-42 MirTarget;miRNATAP -0.347079779358163 3.57314427974497e-57 NA NA NA hsa-miR-200b-3p ZCCHC24 2.11744072703209 1.66710572104191e-43 -1.58022302811898 5.17246192367e-42 MirTarget;TargetScan -0.357208016330032 4.11174945271936e-48 NA NA NA hsa-miR-200c-3p ZCCHC24 2.07038651806183 6.84613386286599e-51 -1.58022302811898 5.17246192367e-42 MirTarget;miRNATAP -0.467865610861613 1.37250115673723e-71 NA NA NA hsa-miR-141-3p ZDHHC15 2.99777540204168 1.26370498493024e-78 -1.79355508284452 1.31588141500882e-28 MirTarget -0.249774889627413 6.41631415358165e-15 NA NA NA hsa-miR-200a-3p ZDHHC15 2.55218480823434 2.96135446816238e-51 -1.79355508284452 1.31588141500882e-28 MirTarget -0.165458951873093 1.87004378841089e-07 NA NA NA hsa-miR-200b-3p ZDHHC15 2.11744072703209 1.66710572104191e-43 -1.79355508284452 1.31588141500882e-28 MirTarget -0.16405872791292 3.5084105128664e-06 NA NA NA hsa-miR-200c-3p ZDHHC15 2.07038651806183 6.84613386286599e-51 -1.79355508284452 1.31588141500882e-28 MirTarget -0.236251197111668 1.04347195201818e-09 NA NA NA hsa-miR-200b-3p ZDHHC17 2.11744072703209 1.66710572104191e-43 -0.866022836216911 6.86139577858733e-36 MirTarget;TargetScan -0.107261278905147 1.41104537315877e-12 NA NA NA hsa-miR-200c-3p ZDHHC17 2.07038651806183 6.84613386286599e-51 -0.866022836216911 6.86139577858733e-36 MirTarget;miRNATAP -0.119261676412732 7.82406651936371e-13 NA NA NA hsa-miR-143-3p ZDHHC23 -1.23248181631499 4.74160976678504e-28 0.639837826532268 9.42867014596828e-12 MirTarget -0.178557364224786 1.43477479054761e-10 NA NA NA hsa-miR-143-3p ZDHHC9 -1.23248181631499 4.74160976678504e-28 0.593578611214802 2.84736765231251e-18 MirTarget;miRNATAP -0.136889743794321 1.63724162274417e-11 NA NA NA hsa-miR-141-3p ZEB1 2.99777540204168 1.26370498493024e-78 -1.20177694006781 1.58231961737395e-22 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.372196262043322 7.31339268489263e-60 24424572;24307282;26783187 Accordingly the enforced expression of miR-200c and mir-141 resulted in a significant upregulation in E-cadherin expression contrary to the significant downregulation in ZEB1 expression in 3 cell lines UTSCC-24A UTSCC-24B and UTSCC-6A cells;It is estimated that miR-141 played its role via ZEB1 and ZEB2; In all miR-141 played a osteosarcoma-suppressing role via ZEB1 and ZEB2;Nintedanib was able to reverse TGF-β1-induced EMT and resistance to gefitinib caused by miR-200b and miR-141 upregulation and ZEB1 downregulation ;;drug resistance head and neck cancer;sarcoma;lung squamous cell cancer hsa-miR-200a-3p ZEB1 2.55218480823434 2.96135446816238e-51 -1.20177694006781 1.58231961737395e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.319622679415122 1.50005867526347e-44 27402080;23626803;24037528;27402864;23743934;24815002;24424572;20473948;19854497;26887977;24390222;26242262;19544444 Conversely ectopic expression of miR-200 inhibited this sprouting by indirectly reducing the protein levels of PDGFRβ through the direct suppression of ZEB1;Concomitant with miR-200 decrease there was an increase in ZEB1 mRNA expression;MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways;This circuit comprises the microRNA 200 miR-200 family ZEB1 and GRHL2;This finding was accompanied by a sharp downregulation in the expression of the miR-200 family of microRNAs well-known targets of ZEB1;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop but otherwise little is known about the transcriptional regulation of the miR-200 family and miR-205;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;GRHL2 miR 200 ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification;Inhibition of ZEB1 by miR 200 characterizes Helicobacter pylori positive gastric diffuse large B cell lymphoma with a less aggressive behavior; Through genome-wide expression profiles of both miRNAs and mRNAs in nine H pylori-positive and nine H pylori-negative gastric diffuse large B-cell lymphomas we identified inhibition of ZEB1 zinc-finger E-box-binding homeobox 1 by miR-200 in H pylori-positive gastric diffuse large B-cell lymphomas; In 30 H pylori-positive and 30 H pylori-negative gastric diffuse large B-cell lymphomas we confirmed that H pylori-positive gastric diffuse large B-cell lymphomas had higher levels of miR-200 by qRT-PCR and lower levels of ZEB1 and higher levels of BCL6 using immunohistochemistry;MiR 200 suppresses metastases of colorectal cancer through ZEB1; Here we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients compared to the paired non-tumor tissue; Moreover the levels of miR-200 and ZEB1 are inversely correlated; Bioinformatics analyses showed that miR-200 targeted the 3'-UTR of ZEB1 mRNA to inhibit its translation which was confirmed by luciferase reporter assay;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2 ;;metastasis;;;;tumorigenesis;;;;;metastasis; breast cancer;breast cancer;breast cancer;sarcoma;endometrial cancer;sarcoma;head and neck cancer;bladder cancer;ovarian cancer;ovarian cancer;B cell lymphoma;colorectal cancer;prostate cancer hsa-miR-200b-3p ZEB1 2.11744072703209 1.66710572104191e-43 -1.20177694006781 1.58231961737395e-22 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.340144365122761 1.59273196940771e-40 27402080;26011542;23626803;24037528;24352645;27402864;23743934;24815002;24424572;20473948;19854497;26887977;24390222;27307751;26242262;19544444;26783187 Conversely ectopic expression of miR-200 inhibited this sprouting by indirectly reducing the protein levels of PDGFRβ through the direct suppression of ZEB1;Here we show that 53BP1 negatively regulated EMT by modulating ZEB1 through targeting microRNA miR-200b and miR-429; In 18 clinical tissue samples expression of 53BP1 was positively correlated with miR-200b and mir-429 and negatively correlated with ZEB1;Concomitant with miR-200 decrease there was an increase in ZEB1 mRNA expression; Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition;MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways;Functional experiments demonstrated that miR-200b suppressed ZEB1 augmented E-cadherin inhibited cell migration and suppressed tumor growth in a mouse model;This circuit comprises the microRNA 200 miR-200 family ZEB1 and GRHL2;This finding was accompanied by a sharp downregulation in the expression of the miR-200 family of microRNAs well-known targets of ZEB1;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop but otherwise little is known about the transcriptional regulation of the miR-200 family and miR-205;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;GRHL2 miR 200 ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification;Inhibition of ZEB1 by miR 200 characterizes Helicobacter pylori positive gastric diffuse large B cell lymphoma with a less aggressive behavior; Through genome-wide expression profiles of both miRNAs and mRNAs in nine H pylori-positive and nine H pylori-negative gastric diffuse large B-cell lymphomas we identified inhibition of ZEB1 zinc-finger E-box-binding homeobox 1 by miR-200 in H pylori-positive gastric diffuse large B-cell lymphomas; In 30 H pylori-positive and 30 H pylori-negative gastric diffuse large B-cell lymphomas we confirmed that H pylori-positive gastric diffuse large B-cell lymphomas had higher levels of miR-200 by qRT-PCR and lower levels of ZEB1 and higher levels of BCL6 using immunohistochemistry;MicroRNA 200b acts as a tumor suppressor in osteosarcoma via targeting ZEB1; Moreover ZEB1 was identified as a target gene of miR-200b and its expression levels were negatively mediated by miR-200b in osteosarcoma cells; Based on these findings our study suggests that miR-200b inhibits the proliferation migration and invasion of osteosarcoma cells probably via the inhibition of ZEB1 expression;MiR 200 suppresses metastases of colorectal cancer through ZEB1; Here we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients compared to the paired non-tumor tissue; Moreover the levels of miR-200 and ZEB1 are inversely correlated; Bioinformatics analyses showed that miR-200 targeted the 3'-UTR of ZEB1 mRNA to inhibit its translation which was confirmed by luciferase reporter assay;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;Nintedanib was able to reverse TGF-β1-induced EMT and resistance to gefitinib caused by miR-200b and miR-141 upregulation and ZEB1 downregulation ;;;metastasis;cell migration;;;;tumorigenesis;;;;;;metastasis;;drug resistance breast cancer;breast cancer;breast cancer;breast cancer;gastric cancer;sarcoma;endometrial cancer;sarcoma;head and neck cancer;bladder cancer;ovarian cancer;ovarian cancer;B cell lymphoma;sarcoma;colorectal cancer;prostate cancer;lung squamous cell cancer hsa-miR-200c-3p ZEB1 2.07038651806183 6.84613386286599e-51 -1.20177694006781 1.58231961737395e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.419256244047077 6.2413741334997e-52 24710933;24615544;21682933;27717206;23626803;27666124;23754305;24424572;24186205;22407310 miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;MiR 200c suppresses TGF β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer; MiR-200c which was the most significantly downregulated miRNA in trastuzumab-resistant cells restored trastuzumab sensitivity and suppressed invasion of breast cancer cells by concurrently targeting ZNF217 a transcriptional activator of TGF-β and ZEB1 a known mediator of TGF-β signaling; Given the reported backward inhibition of miR-200c by ZEB1 ZNF217 also exerts a feedback suppression of miR-200c via TGF-β/ZEB1 signaling; Restoration of miR-200c silencing of ZEB1 or ZNF217 or blockade of TGF-β signaling increased trastuzumab sensitivity and suppressed invasiveness of breast cancer cells;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;Epigenetic Silencing of miR 200c in Breast Cancer Is Associated with Aggressiveness and Is Modulated by ZEB1;Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition;miR 200c regulates crizotinib resistant ALK positive lung cancer cells by reversing epithelial mesenchymal transition via targeting ZEB1;Overexpression of miR-200c in SN12-PM6 and 786-0 cells was concurrent with downregulation of ZEB1 and upregulation of E-cadherin mRNA and protein; Thus our study demonstrated that miR-200c decreases the metastatic ability of renal carcinoma cells by upregulating E-cadherin through ZEB1 and that modulating the expression of miR-200c could influence Akt protein levels;Accordingly the enforced expression of miR-200c and mir-141 resulted in a significant upregulation in E-cadherin expression contrary to the significant downregulation in ZEB1 expression in 3 cell lines UTSCC-24A UTSCC-24B and UTSCC-6A cells;Furthermore miR-200c was found to be important in modulating ZEB1 upregulation by ERG;miR 200c inhibits invasion and migration in human colon cancer cells SW480/620 by targeting ZEB1; Among those dysregulated microRNAs miR-200c was speculated to inhibit metastasis by targeting ZEB1; Overexpression of miR-200c was concurrent with downregulation of ZEB1 mRNA and protein; Taken together our study demonstrated that miR-200c inhibits metastatic ability by targeting ZEB1 in colon cancer cells SW480/620 and suggested that modulation of miR-200c could serve as therapeutic tool for inhibiting metastasis in colorectal cancer metastasis;metastasis;drug resistance;;;;;;;;metastasis breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;lung cancer;kidney renal cell cancer;head and neck cancer;prostate cancer;colon cancer hsa-miR-141-3p ZEB2 2.99777540204168 1.26370498493024e-78 -1.60369039498659 1.13296131497065e-43 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.414576149422103 1.12624955121735e-83 25975736;18925646;24307282 These results suggest that miR‑141 may be involved in the inhibition of gastric cancer cell migration and that ZEB2 is a target gene of miR-141;TargetScan algorithm revealed that ZFHX1B mRNA is a hypothetical target of both miR-141 and -200c; We established by quantitative RT-PCR that in CCCs in which miR-141 and miR-200c were down-regulated ZFHX1B a transcriptional repressor for CDH1/E-cadherin tended to be up-regulated; On the basis of these findings we suggest that down-regulation of miR-141 and miR-200c in CCCs might be involved in suppression of CDH1/E-cadherin transcription via up-regulation of ZFHX1B;It is estimated that miR-141 played its role via ZEB1 and ZEB2; In all miR-141 played a osteosarcoma-suppressing role via ZEB1 and ZEB2 cell migration;; gastric cancer;kidney renal cell cancer;sarcoma hsa-miR-200a-3p ZEB2 2.55218480823434 2.96135446816238e-51 -1.60369039498659 1.13296131497065e-43 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.34961751703046 1.4672767099241e-58 24518294;19787069;24815002;24424572;19854497;21529905;19544444;25797260 This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;MicroRNA 200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E cadherin repressor ZEB2; The 3'-UTR of ZEB2 mRNA a transcriptional repressor of E-cadherin was found to be regulated directly by miR-200a; Our results suggest that loss of expression of miR-200a may play a critical role in the repression of E-cadherin by ZEB2 thereby enhancing migration and invasion in CD133/1+ cells;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;MicroRNA 200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2; Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2; The associations between miR-200a SP cells and ZEB2 were validated in HCC; These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2 ;metastasis;;tumorigenesis;;;;metastasis breast cancer;breast cancer;sarcoma;head and neck cancer;ovarian cancer;ovarian cancer;prostate cancer;liver cancer hsa-miR-200b-3p ZEB2 2.11744072703209 1.66710572104191e-43 -1.60369039498659 1.13296131497065e-43 miRNAWalker2_validate;miRTarBase;MirTarget -0.387016799530245 6.18770056114522e-58 24518294;19787069;24815002;24424572;24769353;19854497;22311119;19544444 This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;Zinc finger E box binding homeobox 2 ZEB2 regulated by miR 200b contributes to multi drug resistance of small cell lung cancer; In silico analysis demonstrated that there are complementary binding sites between miR-200b and ZEB2 3'-UTR and identified miR-200b as a potential regulator of ZEB2; Overexpression of miR-200b led to the downregulation of ZEB2 at protein level; Luciferase reporter gene assay showed that 3'UTR ZEB2 activity was regulated by miR-200b; Our results suggest that ZEB2 modulates drug resistance and is regulated by miR-200b;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;MicroRNA 200b regulates cell proliferation invasion and migration by directly targeting ZEB2 in gastric carcinoma; There was a strong correlation between the levels of miR-200b and ZEB2 and E-cadherin mRNAs in gastric cancer patients; miR-200b regulates ZEB2 expression and thus controls metastasis in gastric cancer;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2 ;metastasis;;tumorigenesis;drug resistance;;metastasis; breast cancer;breast cancer;sarcoma;head and neck cancer;lung squamous cell cancer;ovarian cancer;gastric cancer;prostate cancer hsa-miR-200c-3p ZEB2 2.07038651806183 6.84613386286599e-51 -1.60369039498659 1.13296131497065e-43 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.472673002772748 6.29752478367514e-74 24710933;21682933;26935975;25052237;18925646;24885194 miR-200c has been shown to regulate the epithelial-mesenchymal transition EMT by inhibiting ZEB1 and ZEB2 expression in breast cancer cells; This study further examined the role of miR-200c in the invasion and metastasis of breast cancer that goes beyond the regulation on ZEB1 and ZEB2 expression;Of this family miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2 mediators of epithelial- mesenchymal transition;MicroRNA 200c inhibits the metastasis of non small cell lung cancer cells by targeting ZEB2 an epithelial mesenchymal transition regulator;miR 200c modulates ovarian cancer cell metastasis potential by targeting zinc finger E box binding homeobox 2 ZEB2 expression; Luciferase reporter assay confirmed the target of miR-200c as ZEB2; Furthermore miR-200c expression inhibited ovarian cancer cell ES-2 migration and invasion capacity by suppression of ZEB2 expression p < 0.01; Thus targeting of miR-200c or ZEB2 may serve as a potential therapeutic strategy for control of ovarian cancer;We established by quantitative RT-PCR that in CCCs in which miR-141 and miR-200c were down-regulated ZFHX1B a transcriptional repressor for CDH1/E-cadherin tended to be up-regulated; On the basis of these findings we suggest that down-regulation of miR-141 and miR-200c in CCCs might be involved in suppression of CDH1/E-cadherin transcription via up-regulation of ZFHX1B;Two gastric cancer cell lines were treated with IGF-I to induce EMT and levels of transcription factor ZEB2 and microRNA-200c miR-200c were measured; Furthermore both Akt/ERK inhibitors and knockdown of Akt/ERK gene reversed IGF-I-induced ZEB2 up-regulation and EMT through up-regulation of miR-200c suggesting the involvement of an Akt/ERK-miR-200c-ZEB2 axis in IGF-I-induced EMT metastasis;;metastasis;metastasis;; breast cancer;breast cancer;lung squamous cell cancer;ovarian cancer;kidney renal cell cancer;gastric cancer hsa-miR-141-3p ZFAND5 2.99777540204168 1.26370498493024e-78 -0.766253985974807 3.5779186180608e-35 TargetScan -0.116168365027361 2.44865271331215e-21 NA NA NA hsa-miR-200b-3p ZFAND5 2.11744072703209 1.66710572104191e-43 -0.766253985974807 3.5779186180608e-35 TargetScan;mirMAP -0.129350741948338 3.37113357844796e-22 NA NA NA hsa-miR-200c-3p ZFAND5 2.07038651806183 6.84613386286599e-51 -0.766253985974807 3.5779186180608e-35 mirMAP -0.151662102554221 3.34088379228113e-25 NA NA NA hsa-miR-141-3p ZFHX3 2.99777540204168 1.26370498493024e-78 -0.348999974902257 0.000181853915066663 miRNATAP -0.105617559526677 4.67669171720679e-09 NA NA NA hsa-miR-200a-3p ZFHX3 2.55218480823434 2.96135446816238e-51 -0.348999974902257 0.000181853915066663 miRNATAP -0.1268923645581 5.54301903305533e-13 NA NA NA hsa-miR-28-5p ZFHX3 -0.14267073663385 0.0497619246260571 -0.348999974902257 0.000181853915066663 miRanda -0.167550170989698 0.000163066442653836 NA NA NA hsa-miR-200b-3p ZFHX4 2.11744072703209 1.66710572104191e-43 -1.53229883683245 2.36314851813226e-21 TargetScan -0.426760636969311 6.05019178192894e-37 NA NA NA hsa-miR-200c-3p ZFHX4 2.07038651806183 6.84613386286599e-51 -1.53229883683245 2.36314851813226e-21 miRNATAP -0.513283024255035 1.0110518194279e-44 NA NA NA hsa-miR-141-3p ZFP37 2.99777540204168 1.26370498493024e-78 -1.14029646756092 1.53251959177574e-19 mirMAP -0.162671206194914 5.62333946855471e-11 NA NA NA hsa-miR-200a-3p ZFP37 2.55218480823434 2.96135446816238e-51 -1.14029646756092 1.53251959177574e-19 mirMAP -0.140752734851935 8.25573831207691e-09 NA NA NA hsa-miR-200b-3p ZFP37 2.11744072703209 1.66710572104191e-43 -1.14029646756092 1.53251959177574e-19 mirMAP -0.121061802933701 9.03543574277254e-06 NA NA NA hsa-miR-200c-3p ZFP37 2.07038651806183 6.84613386286599e-51 -1.14029646756092 1.53251959177574e-19 mirMAP -0.15694530363449 1.55941572383231e-07 NA NA NA hsa-miR-28-5p ZFP62 -0.14267073663385 0.0497619246260571 0.325545168406013 2.86196637656788e-07 miRanda -0.13865357278194 4.53335257114054e-06 NA NA NA hsa-miR-141-3p ZFPM2 2.99777540204168 1.26370498493024e-78 -1.48309651759718 5.26430774358294e-23 miRNAWalker2_validate;miRTarBase -0.42417105347186 3.00194018110561e-51 NA NA NA hsa-miR-200a-3p ZFPM2 2.55218480823434 2.96135446816238e-51 -1.48309651759718 5.26430774358294e-23 miRNAWalker2_validate;miRTarBase -0.372246535238814 3.0832686353886e-40 26314828 It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 friend of GATA 2 which directly binds to the p85α regulatory subunit of PI3K lung cancer hsa-miR-200b-3p ZFPM2 2.11744072703209 1.66710572104191e-43 -1.48309651759718 5.26430774358294e-23 miRNAWalker2_validate;miRTarBase;TargetScan -0.40035042800184 1.77712326643107e-37 26314828 It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 friend of GATA 2 which directly binds to the p85α regulatory subunit of PI3K lung cancer hsa-miR-200c-3p ZFPM2 2.07038651806183 6.84613386286599e-51 -1.48309651759718 5.26430774358294e-23 miRNAWalker2_validate;miRTarBase;miRNATAP -0.48840691534348 8.2725500362134e-47 NA NA NA hsa-miR-28-5p ZFYVE21 -0.14267073663385 0.0497619246260571 -0.367598845555907 7.77046925532795e-09 miRanda -0.132662159289845 1.30742694588055e-05 NA NA NA hsa-miR-28-5p ZFYVE26 -0.14267073663385 0.0497619246260571 -0.327493136832778 2.35759136357908e-07 miRanda -0.12447247393372 3.86452573331125e-05 NA NA NA hsa-miR-200a-3p ZIK1 2.55218480823434 2.96135446816238e-51 -1.18368348590858 8.05676664177545e-12 mirMAP -0.154657116864388 3.43609818333755e-06 NA NA NA hsa-miR-132-3p ZKSCAN1 -0.0365213889238607 0.668598301088667 -0.295524595321098 0.0174764449978345 mirMAP -0.100667031211121 0.0459596325088053 NA NA NA hsa-miR-200b-3p ZMAT3 2.11744072703209 1.66710572104191e-43 -0.969402662641862 2.08248828196627e-18 MirTarget;TargetScan -0.199434002125701 2.48176000863477e-17 NA NA NA hsa-miR-200c-3p ZMAT3 2.07038651806183 6.84613386286599e-51 -0.969402662641862 2.08248828196627e-18 MirTarget -0.202683466626764 6.09304654624938e-15 NA NA NA hsa-miR-28-5p ZNF141 -0.14267073663385 0.0497619246260571 -0.339631252919259 3.05959108622568e-05 miRanda -0.125874933389015 0.00121089813530106 NA NA NA hsa-miR-132-3p ZNF148 -0.0365213889238607 0.668598301088667 -0.236797617916435 0.000267463091189989 miRNAWalker2_validate -0.104950156605787 6.47112314290448e-05 NA NA NA hsa-miR-28-5p ZNF19 -0.14267073663385 0.0497619246260571 -0.231757613225705 0.0028772583683754 miRanda -0.153894344201966 3.11401369237391e-05 NA NA NA hsa-miR-28-5p ZNF217 -0.14267073663385 0.0497619246260571 0.418864365129461 2.53498724711067e-05 miRanda -0.153414197347742 0.00124263968059985 NA NA NA hsa-miR-141-3p ZNF385D 2.99777540204168 1.26370498493024e-78 -1.58947730363585 5.76650731569701e-16 MirTarget;TargetScan -0.360073937754939 2.41239444277846e-21 NA NA NA hsa-miR-200a-3p ZNF385D 2.55218480823434 2.96135446816238e-51 -1.58947730363585 5.76650731569701e-16 MirTarget -0.246039133337274 7.25814323833198e-11 NA NA NA hsa-miR-132-3p ZNF395 -0.0365213889238607 0.668598301088667 -0.837643450913783 2.35009090977746e-22 miRNATAP -0.105010677062825 0.00333986646786628 NA NA NA hsa-miR-141-3p ZNF423 2.99777540204168 1.26370498493024e-78 -1.54184148419144 6.10940404866175e-27 mirMAP -0.443714575964303 3.80042072328937e-62 NA NA NA hsa-miR-200a-3p ZNF423 2.55218480823434 2.96135446816238e-51 -1.54184148419144 6.10940404866175e-27 mirMAP -0.372654728096588 5.47923871796623e-44 NA NA NA hsa-miR-200b-3p ZNF423 2.11744072703209 1.66710572104191e-43 -1.54184148419144 6.10940404866175e-27 MirTarget;TargetScan -0.383229276436197 3.18182871747426e-37 NA NA NA hsa-miR-200c-3p ZNF423 2.07038651806183 6.84613386286599e-51 -1.54184148419144 6.10940404866175e-27 MirTarget -0.474923989134754 4.18879723474327e-48 NA NA NA hsa-miR-141-3p ZNF436 2.99777540204168 1.26370498493024e-78 -0.664338506334725 2.34102543837604e-20 TargetScan -0.109198783723963 8.38416009631772e-15 NA NA NA hsa-miR-28-5p ZNF483 -0.14267073663385 0.0497619246260571 -1.79302155637936 8.09598164766452e-31 miRanda -0.161877451760601 0.0353741074383505 NA NA NA hsa-miR-28-5p ZNF484 -0.14267073663385 0.0497619246260571 -0.394911538640617 4.74176735844624e-05 miRanda -0.157201362671009 0.000693734308711223 NA NA NA hsa-miR-200b-3p ZNF532 2.11744072703209 1.66710572104191e-43 -0.486598759081946 3.90195954090326e-08 MirTarget;TargetScan -0.117205676654703 4.02285501003701e-10 NA NA NA hsa-miR-200c-3p ZNF532 2.07038651806183 6.84613386286599e-51 -0.486598759081946 3.90195954090326e-08 MirTarget;miRNATAP -0.123884613316905 1.91112549184569e-09 NA NA NA hsa-let-7e-5p ZNF57 0.261471269338985 0.00191077095550257 0.0888480294702605 0.162908419786358 miRNATAP -0.115582397830129 8.02305677751435e-06 NA NA NA hsa-miR-28-5p ZNF584 -0.14267073663385 0.0497619246260571 0.083372296410301 0.142227608562401 miRanda -0.162509824661307 1.23349297245691e-09 NA NA NA hsa-miR-132-3p ZNF587 -0.0365213889238607 0.668598301088667 0.617628823146323 1.14296232137843e-07 mirMAP -0.181072726741087 0.000133768972872227 NA NA NA hsa-miR-145-5p ZNF593 -2.62703571936687 7.64402900188551e-88 1.03258130709114 2.89883174627819e-20 MirTarget -0.265023606855147 1.3390858228511e-24 NA NA NA hsa-miR-141-3p ZNF608 2.99777540204168 1.26370498493024e-78 -1.41003746006724 7.06391794802511e-20 miRNATAP -0.245314872877093 4.82942927594483e-16 NA NA NA hsa-miR-200a-3p ZNF608 2.55218480823434 2.96135446816238e-51 -1.41003746006724 7.06391794802511e-20 miRNATAP -0.170130673047596 1.34209802137876e-08 NA NA NA hsa-miR-28-5p ZNF609 -0.14267073663385 0.0497619246260571 0.093745834360889 0.193677156970303 miRanda -0.17454071384802 3.08415035241991e-07 NA NA NA hsa-miR-28-5p ZNF615 -0.14267073663385 0.0497619246260571 -0.448908283415558 5.52841871038806e-08 miRanda -0.109992140552008 0.00550144078708249 NA NA NA hsa-miR-28-5p ZNF626 -0.14267073663385 0.0497619246260571 -0.000772536290166048 0.995647761387273 miRanda -0.220256116308172 0.00107200384839584 NA NA NA hsa-miR-141-3p ZNF641 2.99777540204168 1.26370498493024e-78 -0.634238399739506 4.03050324313056e-09 TargetScan -0.105985314592127 4.68550155783422e-07 NA NA NA hsa-miR-132-3p ZNF652 -0.0365213889238607 0.668598301088667 0.213841843999925 0.0221268421718162 miRNAWalker2_validate;MirTarget -0.204923212694746 5.0218733891149e-08 NA NA NA hsa-miR-28-5p ZNF655 -0.14267073663385 0.0497619246260571 -0.550879158758876 1.1977452132855e-09 miRanda -0.10696179348568 0.0141009676103873 NA NA NA hsa-miR-141-3p ZNF660 2.99777540204168 1.26370498493024e-78 -1.67734593603041 3.35110996992824e-30 TargetScan -0.32129698453234 3.12847376313803e-29 NA NA NA hsa-miR-200b-3p ZNF662 2.11744072703209 1.66710572104191e-43 -1.6024130657216 1.19420572254461e-23 TargetScan -0.117742703739421 0.000729368283773752 NA NA NA hsa-miR-28-5p ZNF665 -0.14267073663385 0.0497619246260571 -0.612934521530682 2.18611918652348e-07 miRanda -0.165068213448631 0.00360053988165736 NA NA NA hsa-miR-28-5p ZNF689 -0.14267073663385 0.0497619246260571 -0.187666926528026 0.172159706978396 miRanda -0.251518404206901 0.000117526224448517 NA NA NA hsa-miR-141-3p ZNF704 2.99777540204168 1.26370498493024e-78 -1.29804603210391 1.17161901097451e-16 TargetScan -0.255024301253743 5.95460445406741e-17 NA NA NA hsa-miR-200b-3p ZNF704 2.11744072703209 1.66710572104191e-43 -1.29804603210391 1.17161901097451e-16 mirMAP -0.268391382229473 7.83167159621181e-16 NA NA NA hsa-miR-200c-3p ZNF704 2.07038651806183 6.84613386286599e-51 -1.29804603210391 1.17161901097451e-16 mirMAP -0.24177900119246 5.45204870284249e-11 NA NA NA hsa-miR-28-5p ZNF740 -0.14267073663385 0.0497619246260571 -0.0891625358082004 0.165860174035839 miRanda -0.157571961321932 2.19054782197219e-07 NA NA NA hsa-miR-28-5p ZNF764 -0.14267073663385 0.0497619246260571 0.751807638397205 5.3087214361303e-34 miRanda -0.230605997304356 2.28319062007636e-14 NA NA NA hsa-miR-141-3p ZSCAN23 2.99777540204168 1.26370498493024e-78 -2.20639914562817 4.5304461048684e-22 miRNATAP -0.367100379744908 2.59638181469388e-16 NA NA NA hsa-miR-200a-3p ZSCAN23 2.55218480823434 2.96135446816238e-51 -2.20639914562817 4.5304461048684e-22 miRNATAP -0.279333873604319 2.9414977183278e-10 NA NA NA hsa-miR-28-5p ZSCAN29 -0.14267073663385 0.0497619246260571 0.00304067676335418 0.961086390220188 MirTarget;miRanda -0.102988503595859 0.000492546003786681 NA NA NA hsa-miR-28-5p ZSWIM5 -0.14267073663385 0.0497619246260571 -0.451593352623076 0.00950484344118356 miRanda -0.585836577748603 9.01191284628358e-13 NA NA NA hsa-miR-143-3p ZWILCH -1.23248181631499 4.74160976678504e-28 1.03381159033226 7.18665011100845e-42 MirTarget -0.187189197591078 1.12367001680958e-15 NA NA NA hsa-miR-132-3p ZYG11A -0.0365213889238607 0.668598301088667 1.44456645921069 4.02405528700811e-14 MirTarget -0.31802148684477 5.01405719383014e-05 NA NA NA hsa-miR-141-3p ZYG11B 2.99777540204168 1.26370498493024e-78 -0.676145891271205 1.48820420419549e-24 MirTarget -0.118086071735268 6.40322611989954e-20 NA NA NA hsa-miR-200a-3p ZYG11B 2.55218480823434 2.96135446816238e-51 -0.676145891271205 1.48820420419549e-24 MirTarget -0.11545389241864 8.69498098202584e-20 NA NA NA hsa-miR-200b-3p ZYG11B 2.11744072703209 1.66710572104191e-43 -0.676145891271205 1.48820420419549e-24 TargetScan -0.136849496014765 2.11476478030754e-22 NA NA NA