miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106a-5p AKT3 -0.187436837607903 0.776596826979526 0.199831583262608 0.649870795681386 miRNATAP -0.122915747534173 0.0211707835743014 NA NA NA hsa-miR-106b-5p AKT3 -0.114223082397499 0.918147136717927 0.199831583262608 0.649870795681386 miRNATAP -0.411504731855899 9.49650030459631e-06 NA NA NA hsa-miR-142-3p AKT3 0.0379334054800466 0.978238829636286 0.199831583262608 0.649870795681386 miRanda -0.161022651130634 0.00933730307368185 NA NA NA hsa-miR-15a-5p AKT3 -0.00791539523924278 0.993533724178566 0.199831583262608 0.649870795681386 miRNAWalker2_validate;miRTarBase;miRNATAP -0.374578960806042 0.000213935533400346 NA NA NA hsa-miR-15b-5p AKT3 0.00885606323496901 0.993510047034825 0.199831583262608 0.649870795681386 miRNATAP -0.254367737995205 0.00570754876367863 NA NA NA hsa-miR-16-5p AKT3 0.00657489810438072 0.99567095250359 0.199831583262608 0.649870795681386 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309870666150618 0.000864570425925272 NA NA NA hsa-miR-17-5p AKT3 -0.000596233219692266 0.999589719956144 0.199831583262608 0.649870795681386 TargetScan;miRNATAP -0.174632371966135 0.0291369962045925 NA NA NA hsa-miR-29b-2-5p AKT3 0.0506576777608494 0.914446526694261 0.199831583262608 0.649870795681386 mirMAP -0.233312651843654 0.0174700497895885 NA NA NA hsa-miR-29b-3p AKT3 0.142303641653058 0.900102271992252 0.199831583262608 0.649870795681386 miRNATAP -0.283935483475042 0.000311340903637634 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 -0.318966306994077 0.311417121022653 0.199831583262608 0.649870795681386 mirMAP -0.221762461081726 2.87831776854007e-06 NA NA NA hsa-miR-362-3p AKT3 0.080128943742904 0.76325400634285 0.199831583262608 0.649870795681386 miRanda -0.254988730314174 0.00123561088951897 NA NA NA hsa-miR-501-3p AKT3 -0.213232934691677 0.749134059424389 0.199831583262608 0.649870795681386 miRNATAP -0.18288683695833 0.00732967244086728 NA NA NA hsa-miR-502-3p AKT3 -0.0742971274545239 0.863623336074792 0.199831583262608 0.649870795681386 miRNATAP -0.229135660673546 0.0306493790797631 NA NA NA hsa-miR-93-5p AKT3 -0.103495149722972 0.948829359383178 0.199831583262608 0.649870795681386 miRNATAP -0.334744595445174 0.000214241376596223 NA NA NA hsa-miR-146b-5p BRAF 0.225394330441354 0.853572932708187 0.0273088851580936 0.938865317372996 miRanda -0.100930712558287 0.00870229316842184 21874046;26883911;20406109;21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF ;;; thyroid cancer;thyroid cancer;thyroid cancer;thyroid cancer hsa-miR-200b-3p CAB39 0.00709506191350684 0.995560284306733 0.134027765169603 0.874600006876729 MirTarget;TargetScan -0.100352999717768 0.000212774430958134 NA NA NA hsa-miR-155-5p CAB39L 0.150755193213955 0.894622203994624 0.127325020243824 0.753104487236931 miRNAWalker2_validate -0.241831898238481 1.50039085328912e-06 NA NA NA hsa-miR-33a-3p CAB39L 0.0330412673925473 0.887935183776314 0.127325020243824 0.753104487236931 MirTarget -0.178251426679417 0.00143109659013981 NA NA NA hsa-miR-342-3p CAB39L 0.151626922605026 0.867631856166764 0.127325020243824 0.753104487236931 miRanda -0.293498963224 4.29222779971308e-06 NA NA NA hsa-miR-590-3p CAB39L -0.139003976504018 0.700453857398655 0.127325020243824 0.753104487236931 miRanda -0.306580052495799 1.75898573677086e-05 NA NA NA hsa-miR-590-5p CAB39L -0.173775001452706 0.734742724035795 0.127325020243824 0.753104487236931 miRanda -0.248916652168609 0.000666338759564629 NA NA NA hsa-miR-101-3p DDIT4 -0.0193657214576124 0.99083006485154 -0.114193411231466 0.914489064170073 miRNAWalker2_validate;MirTarget;miRNATAP -0.230006612065332 0.00577054837814306 NA NA NA hsa-miR-181c-5p DDIT4 0.348865067036308 0.609372579266645 -0.114193411231466 0.914489064170073 MirTarget -0.179647243031276 0.029504833372646 NA NA NA hsa-miR-200b-3p DDIT4 0.00709506191350684 0.995560284306733 -0.114193411231466 0.914489064170073 TargetScan -0.146171543167626 0.00840500015299485 NA NA NA hsa-miR-429 DDIT4 -0.202051344131673 0.830298580465583 -0.114193411231466 0.914489064170073 miRanda;miRNATAP -0.117195457851546 0.0237443845462342 NA NA NA hsa-miR-186-5p EIF4E -0.0306736693084426 0.975683742421399 -0.145125902025236 0.818453667891144 mirMAP -0.109966373466399 0.0487146461226767 NA NA NA hsa-miR-30c-5p EIF4E 0.0319636127131169 0.977297378757393 -0.145125902025236 0.818453667891144 mirMAP -0.125333066167818 0.00521766492206099 NA NA NA hsa-miR-125a-5p EIF4EBP1 0.278586710959701 0.804894506541028 -0.297413758151123 0.71045864305601 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.187207630601775 0.00176831220073964 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ovarian cancer hsa-miR-195-3p HIF1A -0.0817091054958705 0.737669463151026 0.0889344059788426 0.927987125518972 MirTarget -0.118735074885987 0.0116494198619885 NA NA NA hsa-miR-28-5p HIF1A 0.112746603967525 0.895983904271527 0.0889344059788426 0.927987125518972 miRanda -0.252846718732826 0.00322964321035346 NA NA NA hsa-miR-320c HIF1A 0.167820674105902 0.355392574548112 0.0889344059788426 0.927987125518972 miRanda -0.106370599251359 0.0472079677919938 NA NA NA hsa-miR-660-5p HIF1A -0.159091178065593 0.822022815348149 0.0889344059788426 0.927987125518972 MirTarget -0.157024364731859 0.0170102371810183 NA NA NA hsa-let-7a-3p IGF1 -0.0587284699785764 0.934080921687498 0.16275205752423 0.738592944377216 mirMAP -0.406421699239252 0.0390765693159235 NA NA NA hsa-let-7f-1-3p IGF1 0.172471926572875 0.566835368063954 0.16275205752423 0.738592944377216 mirMAP -0.918829913577652 3.87495776454398e-08 NA NA NA hsa-miR-103a-2-5p IGF1 0.0554480025996344 0.822359820137576 0.16275205752423 0.738592944377216 mirMAP -0.614783124207912 2.47565479190434e-09 NA NA NA hsa-miR-130b-3p IGF1 -0.10221778777009 0.86290232287018 0.16275205752423 0.738592944377216 MirTarget -0.479757958716119 0.000356022414865848 NA NA NA hsa-miR-15b-3p IGF1 -0.107616988983747 0.885614187998235 0.16275205752423 0.738592944377216 mirMAP -0.729097685666816 2.48630408177257e-07 NA NA NA hsa-miR-16-1-3p IGF1 -0.0202502748147722 0.95639903673924 0.16275205752423 0.738592944377216 mirMAP -0.814562134768682 3.05533338766364e-07 NA NA NA hsa-miR-19a-3p IGF1 -0.015707259355076 0.981874522841226 0.16275205752423 0.738592944377216 MirTarget -0.581899015817695 7.91751221290163e-07 NA NA NA hsa-miR-19b-1-5p IGF1 0.144949250637873 0.755492973890875 0.16275205752423 0.738592944377216 mirMAP -1.02209573815554 6.70473912999913e-10 NA NA NA hsa-miR-19b-3p IGF1 -0.021069663589266 0.98250214127355 0.16275205752423 0.738592944377216 MirTarget -0.831868934390103 1.31473916022842e-07 NA NA NA hsa-miR-20a-3p IGF1 0.00508369553133647 0.989627610532544 0.16275205752423 0.738592944377216 mirMAP -0.765905368079341 1.45024350852968e-08 NA NA NA hsa-miR-27a-3p IGF1 0.089292677549258 0.950107084866822 0.16275205752423 0.738592944377216 miRNAWalker2_validate;miRTarBase -1.09876415117095 2.18608056227336e-11 NA NA NA hsa-miR-301a-3p IGF1 -0.0963781631852707 0.822834348288596 0.16275205752423 0.738592944377216 MirTarget -0.46409260853426 0.000552061816042968 NA NA NA hsa-miR-32-3p IGF1 0.397110511717083 0.0372089477602239 0.16275205752423 0.738592944377216 mirMAP -0.547975732700196 3.20639423670354e-05 NA NA NA hsa-miR-320b IGF1 0.0996601047414365 0.810359465912461 0.16275205752423 0.738592944377216 miRNATAP -0.31660396768362 0.02392662836714 NA NA NA hsa-miR-33a-3p IGF1 0.0330412673925473 0.887935183776314 0.16275205752423 0.738592944377216 MirTarget -0.400091789613134 0.00117684573706475 NA NA NA hsa-miR-452-5p IGF1 0.171578505077356 0.861161653434281 0.16275205752423 0.738592944377216 MirTarget;mirMAP -0.28989018336422 0.00626092588038326 NA NA NA hsa-miR-454-3p IGF1 0.136203543900226 0.745492956399051 0.16275205752423 0.738592944377216 MirTarget -0.396213224507017 0.0181710488414577 NA NA NA hsa-miR-486-5p IGF1 -0.266280723332845 0.763155922987489 0.16275205752423 0.738592944377216 PITA;miRNATAP -0.349556791581636 1.58501267453983e-06 NA NA NA hsa-miR-576-5p IGF1 0.0337415476075185 0.945669616791829 0.16275205752423 0.738592944377216 PITA;mirMAP;miRNATAP -0.686331142925331 4.29578185739691e-05 NA NA NA hsa-miR-590-3p IGF1 -0.139003976504018 0.700453857398655 0.16275205752423 0.738592944377216 MirTarget;miRanda;mirMAP;miRNATAP -0.342383644510283 0.0316335554241828 NA NA NA hsa-miR-629-5p IGF1 0.323677537581911 0.722801100206722 0.16275205752423 0.738592944377216 mirMAP -0.4282336374449 0.000902416424835987 NA NA NA hsa-miR-940 IGF1 -0.209707163727151 0.491573069222592 0.16275205752423 0.738592944377216 MirTarget;PITA;miRNATAP -0.340594099196604 0.00112659190128122 NA NA NA hsa-miR-148b-3p MAPK1 -0.0576480395180932 0.948404126433176 -0.0651808553348747 0.941739122403282 mirMAP -0.139901367015828 0.00442278516722453 NA NA NA hsa-miR-29b-2-5p MAPK1 0.0506576777608494 0.914446526694261 -0.0651808553348747 0.941739122403282 mirMAP -0.150888486209755 2.15475742904008e-05 NA NA NA hsa-miR-29c-3p MAPK1 -0.036782586594942 0.978186488964126 -0.0651808553348747 0.941739122403282 mirMAP -0.121961986993 4.61168241690927e-07 NA NA NA hsa-miR-30b-5p MAPK1 0.0520139321008006 0.961247392125848 -0.0651808553348747 0.941739122403282 mirMAP -0.107494044816223 0.00753809874561411 NA NA NA hsa-miR-30e-5p MAPK1 -0.000980722416395352 0.999509440260479 -0.0651808553348747 0.941739122403282 mirMAP -0.116090988644527 0.00885887810727849 NA NA NA hsa-miR-3913-5p MAPK1 -0.0226857734721915 0.929747532799218 -0.0651808553348747 0.941739122403282 mirMAP -0.108088444698366 0.00439552964093496 NA NA NA hsa-miR-2355-5p PDPK1 -0.0334225912650465 0.961955002329649 -0.028535329397231 0.967987163463861 mirMAP -0.103108226134942 0.00842031347464144 NA NA NA hsa-miR-28-5p PDPK1 0.112746603967525 0.895983904271527 -0.028535329397231 0.967987163463861 mirMAP -0.149518166466328 0.0313711047974397 NA NA NA hsa-miR-29a-3p PDPK1 0.144361548745149 0.928458118904984 -0.028535329397231 0.967987163463861 mirMAP -0.100922062654505 0.0215030765797257 NA NA NA hsa-miR-320a PDPK1 0.0409153600352639 0.972867457397282 -0.028535329397231 0.967987163463861 miRanda -0.124994788730937 0.0146141071926921 NA NA NA hsa-miR-331-3p PDPK1 0.077109379325961 0.890258380743369 -0.028535329397231 0.967987163463861 miRNAWalker2_validate -0.121492218481836 0.00927780113542185 NA NA NA hsa-miR-335-5p PDPK1 -0.0876284717522751 0.822280642381487 -0.028535329397231 0.967987163463861 mirMAP -0.119757895953739 0.000897643278107525 NA NA NA hsa-miR-374a-3p PDPK1 -0.0356287422567689 0.977336526097337 -0.028535329397231 0.967987163463861 mirMAP -0.230622538416318 1.68353183571966e-05 NA NA NA hsa-miR-374b-5p PDPK1 -0.120825593958128 0.872556407127498 -0.028535329397231 0.967987163463861 miRNATAP -0.196301486044882 0.00227955878743118 NA NA NA hsa-miR-424-5p PDPK1 0.16707104746762 0.861761331304308 -0.028535329397231 0.967987163463861 mirMAP -0.107328960543962 0.00321761385868636 NA NA NA hsa-miR-505-3p PDPK1 0.0904771226634438 0.888362266571214 -0.028535329397231 0.967987163463861 mirMAP -0.160675222484928 0.00135084804850823 NA NA NA hsa-miR-542-3p PDPK1 0.0249538855043179 0.980961788520878 -0.028535329397231 0.967987163463861 mirMAP -0.121946343385412 0.0159486604359987 NA NA NA hsa-miR-590-3p PDPK1 -0.139003976504018 0.700453857398655 -0.028535329397231 0.967987163463861 miRanda;miRNATAP -0.153973762930792 0.00126758596013474 NA NA NA hsa-miR-628-5p PDPK1 0.144074887692676 0.702367845018739 -0.028535329397231 0.967987163463861 PITA;miRNATAP -0.115391651807753 0.0275743788666497 NA NA NA hsa-miR-7-1-3p PDPK1 0.0894020440145336 0.872338669592458 -0.028535329397231 0.967987163463861 mirMAP -0.167155439005958 0.000480585137518429 NA NA NA hsa-miR-708-3p PDPK1 -0.031256206275331 0.971143939902443 -0.028535329397231 0.967987163463861 miRNATAP -0.102610127578191 0.00176122802875978 NA NA NA hsa-miR-34a-5p PGF -0.181045462699335 0.846186442909868 -0.480138614362629 0.386394557766377 miRNATAP -0.469702846148815 0.00034617557544533 NA NA NA hsa-miR-429 PGF -0.202051344131673 0.830298580465583 -0.480138614362629 0.386394557766377 miRNATAP -0.260855037574621 0.000203354450361377 NA NA NA hsa-miR-146b-5p PIK3CA 0.225394330441354 0.853572932708187 -0.0161779911076492 0.978472905430507 mirMAP -0.104188309355891 0.0214970111401642 NA NA NA hsa-miR-148b-3p PIK3CA -0.0576480395180932 0.948404126433176 -0.0161779911076492 0.978472905430507 miRNAWalker2_validate -0.244141801200414 0.00147579635788138 NA NA NA hsa-miR-186-5p PIK3CA -0.0306736693084426 0.975683742421399 -0.0161779911076492 0.978472905430507 mirMAP -0.280960133798979 0.000232701716483115 NA NA NA hsa-miR-29b-1-5p PIK3CA 0.0803356397596426 0.788717272901724 -0.0161779911076492 0.978472905430507 mirMAP -0.12089066483943 0.00233700941849917 NA NA NA hsa-miR-320a PIK3CA 0.0409153600352639 0.972867457397282 -0.0161779911076492 0.978472905430507 miRanda -0.128981884483952 0.0152314868443974 NA NA NA hsa-miR-320b PIK3CA 0.0996601047414365 0.810359465912461 -0.0161779911076492 0.978472905430507 miRanda -0.121444800770151 0.00550932456475504 NA NA NA hsa-miR-335-5p PIK3CA -0.0876284717522751 0.822280642381487 -0.0161779911076492 0.978472905430507 miRNAWalker2_validate -0.124494566731403 0.000883627732385134 NA NA NA hsa-miR-338-5p PIK3CA -0.0570309768373674 0.852806138741879 -0.0161779911076492 0.978472905430507 mirMAP -0.108048495334147 0.00046563589386498 NA NA NA hsa-miR-339-5p PIK3CA -0.0440073754970829 0.947512460035341 -0.0161779911076492 0.978472905430507 miRanda -0.13798173006655 0.00178425799549926 NA NA NA hsa-miR-501-5p PIK3CA -0.0281755984621284 0.914828113245766 -0.0161779911076492 0.978472905430507 mirMAP -0.120904681333791 0.00473986403400753 NA NA NA hsa-miR-590-3p PIK3CA -0.139003976504018 0.700453857398655 -0.0161779911076492 0.978472905430507 miRanda;mirMAP -0.12312207550598 0.0133629325751335 NA NA NA hsa-miR-130a-3p PIK3CB 0.474579081939985 0.589020231280429 -0.0874582158659543 0.903470610317962 miRNATAP -0.116582529549782 0.00106378240800672 NA NA NA hsa-miR-19b-3p PIK3CB -0.021069663589266 0.98250214127355 -0.0874582158659543 0.903470610317962 miRNATAP -0.110401307134748 0.00639042894521705 NA NA NA hsa-miR-1468-5p PIK3CD 0.0764759802054626 0.786786741372286 0.21003873016187 0.718193001495828 MirTarget -0.153354934509346 0.00559561965869134 NA NA NA hsa-miR-199a-5p PIK3CD -0.190333205251807 0.873282228777943 0.21003873016187 0.718193001495828 MirTarget;PITA;miRanda;miRNATAP -0.160352223725155 0.000860262558034989 NA NA NA hsa-miR-30d-5p PIK3CD 0.00832663322567129 0.995690909022542 0.21003873016187 0.718193001495828 MirTarget;miRNATAP -0.269704587228763 0.00722775970426478 NA NA NA hsa-miR-324-5p PIK3CD -0.00384551840892744 0.994555888813517 0.21003873016187 0.718193001495828 miRanda -0.167057802158617 0.010407823026026 NA NA NA hsa-miR-3913-5p PIK3CD -0.0226857734721915 0.929747532799218 0.21003873016187 0.718193001495828 mirMAP -0.258109601835399 0.00117084989668902 NA NA NA hsa-miR-335-3p PIK3CG 0.0459461858975514 0.956171824626465 0.0897276739578496 0.720712418685465 mirMAP -0.289128547018831 6.98940085423769e-06 NA NA NA hsa-miR-502-5p PIK3CG -0.399402466528722 0.0371413760055171 0.0897276739578496 0.720712418685465 miRNATAP -0.170404506210511 0.0284752528790852 26163264 Phosphoinositide 3-kinase catalytic subunit gamma PIK3CG was identified as a direct downstream target of miR-502 in HCC cells; Notably overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells liver cancer hsa-miR-1301-3p PIK3R1 0.215916819876655 0.634872511522417 -0.148543685192655 0.832676990930827 MirTarget -0.135408648859421 0.0487168326048714 NA NA NA hsa-miR-16-2-3p PIK3R1 -0.0660098106740605 0.907925706907323 -0.148543685192655 0.832676990930827 MirTarget -0.220421111740374 0.0054973163518176 NA NA NA hsa-miR-16-5p PIK3R1 0.00657489810438072 0.99567095250359 -0.148543685192655 0.832676990930827 MirTarget -0.232718839097215 0.0094069232214411 NA NA NA hsa-miR-17-5p PIK3R1 -0.000596233219692266 0.999589719956144 -0.148543685192655 0.832676990930827 MirTarget;TargetScan;miRNATAP -0.263550021803503 0.000561403048031031 NA NA NA hsa-miR-182-5p PIK3R1 -0.123533474001965 0.944870865201631 -0.148543685192655 0.832676990930827 miRNATAP -0.123631904426682 0.0246928295730376 NA NA NA hsa-miR-200c-3p PIK3R1 0.100908924677178 0.952192851702623 -0.148543685192655 0.832676990930827 mirMAP -0.209884750055895 0.000971059963262446 NA NA NA hsa-miR-20a-5p PIK3R1 0.0114792099504992 0.991781949567624 -0.148543685192655 0.832676990930827 MirTarget;miRNATAP -0.16773716444277 0.0232604396745217 NA NA NA hsa-miR-21-5p PIK3R1 0.102402561735872 0.965099645724328 -0.148543685192655 0.832676990930827 miRNAWalker2_validate;MirTarget;miRNATAP -0.296975751298422 0.0179761051209979 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 -0.0119558238852235 0.98487566102761 -0.148543685192655 0.832676990930827 mirMAP -0.166300707017564 0.0322007854872272 NA NA NA hsa-miR-29a-3p PIK3R1 0.144361548745149 0.928458118904984 -0.148543685192655 0.832676990930827 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.158482628577245 0.03846338914674 NA NA NA hsa-miR-29b-3p PIK3R1 0.142303641653058 0.900102271992252 -0.148543685192655 0.832676990930827 MirTarget;miRNATAP -0.229458801110313 0.00247922380727846 NA NA NA hsa-miR-3065-5p PIK3R1 -0.318966306994077 0.311417121022653 -0.148543685192655 0.832676990930827 MirTarget;mirMAP;miRNATAP -0.136442762182432 0.00300321263691178 NA NA NA hsa-miR-32-3p PIK3R1 0.397110511717083 0.0372089477602239 -0.148543685192655 0.832676990930827 mirMAP -0.159533357320395 0.0224038643587963 NA NA NA hsa-miR-320b PIK3R1 0.0996601047414365 0.810359465912461 -0.148543685192655 0.832676990930827 miRNATAP -0.176164651324681 0.0166344864485862 NA NA NA hsa-miR-320c PIK3R1 0.167820674105902 0.355392574548112 -0.148543685192655 0.832676990930827 miRNATAP -0.237528056213487 0.00153215444016214 NA NA NA hsa-miR-330-3p PIK3R1 -0.011452549052418 0.970394129262563 -0.148543685192655 0.832676990930827 MirTarget;PITA;miRNATAP -0.222421511130143 0.000560333266659095 NA NA NA hsa-miR-335-3p PIK3R1 0.0459461858975514 0.956171824626465 -0.148543685192655 0.832676990930827 mirMAP -0.187424798668302 0.00154671007013318 NA NA NA hsa-miR-338-5p PIK3R1 -0.0570309768373674 0.852806138741879 -0.148543685192655 0.832676990930827 PITA -0.149038254580324 0.00415133065382571 NA NA NA hsa-miR-455-3p PIK3R1 0.137296059937864 0.889752053946795 -0.148543685192655 0.832676990930827 MirTarget;PITA;miRNATAP -0.154714937051356 0.0121083771583488 NA NA NA hsa-miR-582-5p PIK3R1 0.0391293212300696 0.945368171372496 -0.148543685192655 0.832676990930827 mirMAP -0.168928206892885 0.000293205730117536 NA NA NA hsa-miR-584-5p PIK3R1 0.190228408166915 0.803568824349321 -0.148543685192655 0.832676990930827 mirMAP -0.264485629334745 3.0909574049315e-09 NA NA NA hsa-miR-590-3p PIK3R1 -0.139003976504018 0.700453857398655 -0.148543685192655 0.832676990930827 miRanda;mirMAP -0.189026585514548 0.0237715511845409 NA NA NA hsa-miR-590-5p PIK3R1 -0.173775001452706 0.734742724035795 -0.148543685192655 0.832676990930827 MirTarget;PITA;miRanda;miRNATAP -0.297003967343676 0.000452335914243657 NA NA NA hsa-miR-629-3p PIK3R1 0.264171606611622 0.479075142876712 -0.148543685192655 0.832676990930827 MirTarget -0.21216292379107 0.00105654186835094 NA NA NA hsa-miR-1271-5p PIK3R3 0.113785697335253 0.664637583993702 0.00978105554023401 0.989576204398345 mirMAP -0.151933011438603 0.00299533512999816 NA NA NA hsa-miR-18a-3p PIK3R3 0.047371679150885 0.849100837614421 0.00978105554023401 0.989576204398345 miRNAWalker2_validate -0.172437749406846 8.76134189601592e-05 NA NA NA hsa-miR-19b-3p PIK3R3 -0.021069663589266 0.98250214127355 0.00978105554023401 0.989576204398345 MirTarget;miRNATAP -0.133034812969295 0.0429014365024994 NA NA NA hsa-miR-222-5p PIK3R3 0.330318684461812 0.489738152851363 0.00978105554023401 0.989576204398345 mirMAP -0.169591357898129 3.80520658072856e-05 NA NA NA hsa-miR-26b-5p PIK3R3 -0.00510702880331593 0.996607798179271 0.00978105554023401 0.989576204398345 miRNATAP -0.161901214865155 0.0389212618860389 NA NA NA hsa-miR-29b-1-5p PIK3R3 0.0803356397596426 0.788717272901724 0.00978105554023401 0.989576204398345 mirMAP -0.214703534793861 3.15537480066889e-05 NA NA NA hsa-miR-32-5p PIK3R3 0.0628705653766719 0.926491719877421 0.00978105554023401 0.989576204398345 MirTarget;miRNATAP -0.160755914279694 0.019115600005757 NA NA NA hsa-miR-330-3p PIK3R3 -0.011452549052418 0.970394129262563 0.00978105554023401 0.989576204398345 MirTarget -0.191183653307302 0.000135580399986553 NA NA NA hsa-miR-330-5p PIK3R3 0.00970192961000116 0.988324849760483 0.00978105554023401 0.989576204398345 miRanda -0.158989578902319 0.00262587059425892 NA NA NA hsa-miR-335-3p PIK3R3 0.0459461858975514 0.956171824626465 0.00978105554023401 0.989576204398345 mirMAP -0.103464572034936 0.025428137853466 NA NA NA hsa-miR-365a-3p PIK3R3 -0.0207610057665999 0.977200565399858 0.00978105554023401 0.989576204398345 MirTarget -0.330277583325266 6.38384266733533e-09 NA NA NA hsa-miR-511-5p PIK3R3 0.16436177858313 0.680167129063066 0.00978105554023401 0.989576204398345 MirTarget -0.179185145111208 6.38466351145281e-06 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-590-3p PIK3R3 -0.139003976504018 0.700453857398655 0.00978105554023401 0.989576204398345 PITA;mirMAP;miRNATAP -0.135597711481687 0.0374254282287608 NA NA NA hsa-miR-590-5p PIK3R3 -0.173775001452706 0.734742724035795 0.00978105554023401 0.989576204398345 miRanda -0.195493025557274 0.00311783468590026 NA NA NA hsa-miR-92a-3p PIK3R3 0.0335965904378064 0.984787550750779 0.00978105554023401 0.989576204398345 MirTarget;miRNATAP -0.181892014402978 0.0174346731946844 NA NA NA hsa-miR-125a-3p PIK3R5 0.119245934253913 0.752909794176976 0.0650949060705845 0.852818680663509 miRanda -0.143772140191083 0.00747323319002246 NA NA NA hsa-miR-125a-5p PIK3R5 0.278586710959701 0.804894506541028 0.0650949060705845 0.852818680663509 MirTarget;miRanda -0.250957855170204 0.00223286885929377 NA NA NA hsa-miR-182-5p PIK3R5 -0.123533474001965 0.944870865201631 0.0650949060705845 0.852818680663509 MirTarget -0.25329203027594 9.2894340160784e-07 NA NA NA hsa-let-7a-3p PRKAA1 -0.0587284699785764 0.934080921687498 0.0942500925652965 0.90483512948759 MirTarget;mirMAP -0.103640049569626 0.0488193422044429 NA NA NA hsa-miR-146b-3p PRKAA1 0.315037387100506 0.717101167551485 0.0942500925652965 0.90483512948759 MirTarget;PITA;miRNATAP -0.102428064257974 0.0140358952550927 NA NA NA hsa-miR-19a-3p PRKAA1 -0.015707259355076 0.981874522841226 0.0942500925652965 0.90483512948759 miRNATAP -0.121877936085399 0.000121351742732488 NA NA NA hsa-miR-19b-3p PRKAA1 -0.021069663589266 0.98250214127355 0.0942500925652965 0.90483512948759 miRNAWalker2_validate;miRTarBase;miRNATAP -0.1436893824791 0.000755247351571621 NA NA NA hsa-miR-30e-5p PRKAA1 -0.000980722416395352 0.999509440260479 0.0942500925652965 0.90483512948759 miRNAWalker2_validate -0.133460271873218 0.0244955162776443 NA NA NA hsa-miR-590-3p PRKAA1 -0.139003976504018 0.700453857398655 0.0942500925652965 0.90483512948759 MirTarget;miRanda;mirMAP -0.159819133040541 0.000152519009478064 NA NA NA hsa-miR-590-5p PRKAA1 -0.173775001452706 0.734742724035795 0.0942500925652965 0.90483512948759 miRanda -0.127622456320397 0.00312575183340519 NA NA NA hsa-miR-664a-3p PRKAA1 0.0410470241619301 0.941262864923951 0.0942500925652965 0.90483512948759 mirMAP -0.10274838049592 0.0430281307633151 NA NA NA hsa-let-7f-1-3p PRKAA2 0.172471926572875 0.566835368063954 0.393744366356652 0.454992497322934 mirMAP -0.455040250473054 0.0176468056824286 NA NA NA hsa-let-7i-5p PRKAA2 0.0354095877029117 0.974843999181856 0.393744366356652 0.454992497322934 MirTarget -0.810091839705212 0.0129417811800294 NA NA NA hsa-miR-142-5p PRKAA2 -0.0238817383727534 0.977605999057627 0.393744366356652 0.454992497322934 mirMAP -0.733679899144415 3.28129434658743e-09 NA NA NA hsa-miR-146a-5p PRKAA2 0.0586284112493756 0.948902113399441 0.393744366356652 0.454992497322934 MirTarget -0.510281421549701 3.0466836944546e-05 NA NA NA hsa-miR-146b-5p PRKAA2 0.225394330441354 0.853572932708187 0.393744366356652 0.454992497322934 MirTarget -0.677636044535875 2.66207392598239e-05 NA NA NA hsa-miR-150-3p PRKAA2 0.165240386153569 0.559232935622423 0.393744366356652 0.454992497322934 MirTarget;miRNATAP -0.563781561577572 7.53911077950056e-08 NA NA NA hsa-miR-203a-3p PRKAA2 -0.148899926796224 0.936624137891012 0.393744366356652 0.454992497322934 MirTarget -0.432436265326421 3.35611293563868e-09 NA NA NA hsa-miR-22-5p PRKAA2 -0.0119558238852235 0.98487566102761 0.393744366356652 0.454992497322934 mirMAP -0.470263121239052 0.00457421554834218 NA NA NA hsa-miR-23a-3p PRKAA2 -0.000919962616247716 0.999510817457789 0.393744366356652 0.454992497322934 mirMAP -0.71119737453032 0.00405550837945771 NA NA NA hsa-miR-27b-5p PRKAA2 0.058980968469637 0.925628316966898 0.393744366356652 0.454992497322934 MirTarget;miRNATAP -0.60817407358398 8.32905119807132e-05 NA NA NA hsa-miR-31-5p PRKAA2 0.759827937199763 0.3450065567671 0.393744366356652 0.454992497322934 MirTarget -0.15712514023853 0.0385705528408463 NA NA NA hsa-miR-330-3p PRKAA2 -0.011452549052418 0.970394129262563 0.393744366356652 0.454992497322934 MirTarget -0.35013720335909 0.011596764028349 NA NA NA hsa-miR-342-3p PRKAA2 0.151626922605026 0.867631856166764 0.393744366356652 0.454992497322934 PITA -1.02655657966323 4.19058043429419e-11 NA NA NA hsa-miR-34c-3p PRKAA2 0.0859582208781462 0.847839909438013 0.393744366356652 0.454992497322934 PITA -0.348300367275928 2.34411683541998e-05 NA NA NA hsa-miR-34c-5p PRKAA2 -0.146449591856554 0.765328802566255 0.393744366356652 0.454992497322934 miRNATAP -0.346761506200615 2.1638696771148e-05 NA NA NA hsa-miR-590-3p PRKAA2 -0.139003976504018 0.700453857398655 0.393744366356652 0.454992497322934 mirMAP;miRNATAP -0.47594243821822 0.00777370830247716 NA NA NA hsa-miR-944 PRKAA2 -0.316321233715507 0.703644676773439 0.393744366356652 0.454992497322934 mirMAP -0.379896831337975 2.22682094114287e-14 NA NA NA hsa-miR-15b-3p RICTOR -0.107616988983747 0.885614187998235 0.0549312293928139 0.934768504878452 mirMAP -0.11740177171332 0.00224919531203597 NA NA NA hsa-miR-16-1-3p RICTOR -0.0202502748147722 0.95639903673924 0.0549312293928139 0.934768504878452 MirTarget -0.140860525900497 0.00111056845182421 NA NA NA hsa-miR-186-5p RICTOR -0.0306736693084426 0.975683742421399 0.0549312293928139 0.934768504878452 mirMAP -0.141684569038438 0.0316026896909575 NA NA NA hsa-miR-188-5p RICTOR 0.104867166668688 0.681237247873533 0.0549312293928139 0.934768504878452 MirTarget;PITA;miRNATAP -0.113436557582237 0.00114377309629276 NA NA NA hsa-miR-26b-3p RICTOR -0.0453681991376325 0.934179862859451 0.0549312293928139 0.934768504878452 MirTarget -0.140410757088931 0.00252166122507131 NA NA NA hsa-miR-590-3p RICTOR -0.139003976504018 0.700453857398655 0.0549312293928139 0.934768504878452 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.118472016725884 0.00542901063543767 NA NA NA hsa-miR-660-5p RICTOR -0.159091178065593 0.822022815348149 0.0549312293928139 0.934768504878452 MirTarget -0.198510445302814 2.18207380719342e-05 NA NA NA hsa-miR-652-3p RPS6 0.0104026261071013 0.986667400308364 -0.0621510394250464 0.962808337713038 miRNAWalker2_validate -0.113020751926823 0.0390721941234289 NA NA NA hsa-miR-1271-5p RPS6KA2 0.113785697335253 0.664637583993702 0.207134557901885 0.725832669400917 mirMAP -0.205729695165376 0.00268820251345792 NA NA NA hsa-miR-130b-5p RPS6KA2 0.00981184097227628 0.984687547329972 0.207134557901885 0.725832669400917 mirMAP -0.161257037562344 0.0262206471601351 NA NA NA hsa-miR-17-5p RPS6KA2 -0.000596233219692266 0.999589719956144 0.207134557901885 0.725832669400917 TargetScan -0.277716691933536 0.000491109025542043 NA NA NA hsa-miR-193a-3p RPS6KA2 0.124767397400679 0.792318041473515 0.207134557901885 0.725832669400917 mirMAP -0.243071120724014 0.00506444605891364 NA NA NA hsa-miR-19a-3p RPS6KA2 -0.015707259355076 0.981874522841226 0.207134557901885 0.725832669400917 MirTarget -0.152609329730918 0.0198831680978397 NA NA NA hsa-miR-19b-3p RPS6KA2 -0.021069663589266 0.98250214127355 0.207134557901885 0.725832669400917 MirTarget -0.275239570627294 0.00167663626230614 NA NA NA hsa-miR-200b-3p RPS6KA2 0.00709506191350684 0.995560284306733 0.207134557901885 0.725832669400917 TargetScan -0.139665509136457 0.0224100703450016 NA NA NA hsa-miR-200c-3p RPS6KA2 0.100908924677178 0.952192851702623 0.207134557901885 0.725832669400917 miRNATAP -0.185226101150327 0.005371700638205 NA NA NA hsa-miR-21-3p RPS6KA2 0.070706380594066 0.962928202615693 0.207134557901885 0.725832669400917 MirTarget -0.163609468058562 0.0316623495188542 NA NA NA hsa-miR-30e-5p RPS6KA2 -0.000980722416395352 0.999509440260479 0.207134557901885 0.725832669400917 MirTarget -0.487113159267505 5.36366592420531e-05 NA NA NA hsa-miR-378a-3p RPS6KA2 -0.10397801708609 0.926379698635758 0.207134557901885 0.725832669400917 MirTarget -0.251494688876595 2.23223122446489e-05 NA NA NA hsa-miR-378c RPS6KA2 0.0461179468701558 0.91229972072848 0.207134557901885 0.725832669400917 MirTarget -0.194068395078508 0.00355016245964441 NA NA NA hsa-miR-429 RPS6KA2 -0.202051344131673 0.830298580465583 0.207134557901885 0.725832669400917 miRanda;miRNATAP -0.138769784739592 0.0149762890263963 NA NA NA hsa-miR-532-3p RPS6KA2 0.0299059710198204 0.962923289121957 0.207134557901885 0.725832669400917 MirTarget;mirMAP -0.174470506125003 0.0421379812196571 NA NA NA hsa-miR-9-3p RPS6KA2 -0.569626685515492 0.198367177172169 0.207134557901885 0.725832669400917 MirTarget -0.173109404251115 1.61584766530112e-05 NA NA NA hsa-miR-9-5p RPS6KA2 -0.273546060420712 0.860070397379663 0.207134557901885 0.725832669400917 miRNATAP -0.179360056481064 3.30496459020001e-07 NA NA NA hsa-miR-93-3p RPS6KA2 -0.0797448554472107 0.871437048494161 0.207134557901885 0.725832669400917 MirTarget -0.217667623628836 0.0112046025164847 NA NA NA hsa-miR-181a-5p RPS6KA3 0.131241012385924 0.917256096248893 -0.0262238719386856 0.972975485871589 MirTarget;mirMAP;miRNATAP -0.106406786311859 0.0367668462596945 NA NA NA hsa-miR-181b-5p RPS6KA3 0.281236821240558 0.780421351344992 -0.0262238719386856 0.972975485871589 MirTarget;mirMAP;miRNATAP -0.112839712951235 0.0171239910921931 NA NA NA hsa-miR-141-3p RPS6KA6 0.14341518885497 0.909724976567544 -0.323537484605024 0.65108047319772 MirTarget -0.30702156340192 0.00250736247952691 NA NA NA hsa-miR-15a-5p RPS6KA6 -0.00791539523924278 0.993533724178566 -0.323537484605024 0.65108047319772 MirTarget -0.459730354892647 0.0113925514456985 NA NA NA hsa-miR-15b-5p RPS6KA6 0.00885606323496901 0.993510047034825 -0.323537484605024 0.65108047319772 MirTarget -0.630779583352634 0.000112057448754317 NA NA NA hsa-miR-16-5p RPS6KA6 0.00657489810438072 0.99567095250359 -0.323537484605024 0.65108047319772 MirTarget -0.757078300034172 4.28813440897308e-06 NA NA NA hsa-miR-17-5p RPS6KA6 -0.000596233219692266 0.999589719956144 -0.323537484605024 0.65108047319772 TargetScan -0.429125605520815 0.00257843057134291 NA NA NA hsa-miR-19b-3p RPS6KA6 -0.021069663589266 0.98250214127355 -0.323537484605024 0.65108047319772 MirTarget -0.408003865579579 0.00914510270200835 NA NA NA hsa-miR-20a-3p RPS6KA6 0.00508369553133647 0.989627610532544 -0.323537484605024 0.65108047319772 MirTarget -0.367180983126307 0.00636307573029767 NA NA NA hsa-miR-590-3p RPS6KA6 -0.139003976504018 0.700453857398655 -0.323537484605024 0.65108047319772 MirTarget;miRanda;mirMAP;miRNATAP -0.349462886885253 0.0245876539993856 NA NA NA hsa-miR-107 RPS6KB1 -0.143562673728446 0.855954506542642 0.0772974274456661 0.911313771844833 PITA;miRanda -0.111469431880308 0.00608626394063609 NA NA NA hsa-miR-186-5p RPS6KB1 -0.0306736693084426 0.975683742421399 0.0772974274456661 0.911313771844833 MirTarget;miRNATAP -0.188202471127657 8.10651969496359e-05 NA NA NA hsa-miR-125a-5p RPS6KB2 0.278586710959701 0.804894506541028 -0.0642123724424106 0.933403566214688 miRanda -0.169895564703728 2.13927288529754e-05 NA NA NA hsa-miR-330-3p STK11 -0.011452549052418 0.970394129262563 -0.0414809031435279 0.956163766947207 mirMAP -0.180754893902168 0.000195158543898518 NA NA NA hsa-miR-330-5p STK11 0.00970192961000116 0.988324849760483 -0.0414809031435279 0.956163766947207 miRanda -0.228906258010212 6.30285088801753e-06 NA NA NA hsa-miR-186-5p STRADA -0.0306736693084426 0.975683742421399 0.135305448896668 0.830408444058658 mirMAP -0.121596994850888 0.00876934553024345 NA NA NA hsa-miR-28-3p TSC1 0.113381981436428 0.941159387516642 0.026141164287198 0.968322032405245 PITA -0.163451002258092 1.1903394911001e-05 NA NA NA hsa-miR-29a-5p TSC1 0.18117722740642 0.583528211572362 0.026141164287198 0.968322032405245 mirMAP -0.105441022835942 0.000632720914912164 NA NA NA hsa-miR-26a-5p ULK1 0.110457386875835 0.937612316892532 0.00986630779884745 0.990037665672495 miRNATAP -0.105829040115447 0.0406131161320187 NA NA NA hsa-miR-320b ULK1 0.0996601047414365 0.810359465912461 0.00986630779884745 0.990037665672495 miRNATAP -0.108910810166154 0.00132925139550834 NA NA NA hsa-miR-338-5p ULK1 -0.0570309768373674 0.852806138741879 0.00986630779884745 0.990037665672495 PITA -0.112202073160501 2.4272733560777e-06 NA NA NA hsa-miR-92b-3p ULK1 0.0384207118756841 0.96614275955977 0.00986630779884745 0.990037665672495 miRNATAP -0.113736844338434 0.000111525465678901 NA NA NA hsa-let-7f-1-3p ULK2 0.172471926572875 0.566835368063954 0.000532113860558958 0.99923505978824 MirTarget -0.169070136832637 0.000783570124708853 NA NA NA hsa-miR-223-3p ULK2 -0.158369224610663 0.882821258727862 0.000532113860558958 0.99923505978824 MirTarget -0.110637001615717 6.20860268153876e-05 NA NA NA hsa-miR-590-3p ULK2 -0.139003976504018 0.700453857398655 0.000532113860558958 0.99923505978824 mirMAP -0.131449068842525 0.0052852077242265 NA NA NA hsa-miR-28-5p ULK3 0.112746603967525 0.895983904271527 0.0510398901834002 0.944086425799587 miRanda -0.133404722791077 0.0170548889962234 NA NA NA hsa-miR-101-3p VEGFA -0.0193657214576124 0.99083006485154 -0.114725328921871 0.904352276270392 miRNAWalker2_validate -0.44049017437003 2.14988554587478e-10 NA NA NA hsa-miR-140-5p VEGFA 0.00336106346701115 0.995849031446338 -0.114725328921871 0.904352276270392 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.25107167892515 0.00261330338296037 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-145-5p VEGFA 0.117108956023007 0.928840184064825 -0.114725328921871 0.904352276270392 miRNAWalker2_validate;miRTarBase -0.128423755259373 0.00677881518234136 24781864;24966896;22472569 Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically metastasis;; thyroid cancer;bladder cancer;sarcoma hsa-miR-150-5p VEGFA 0.182073863939202 0.880089818795655 -0.114725328921871 0.904352276270392 miRNAWalker2_validate;miRTarBase -0.190454559321715 1.05415152205695e-07 NA NA NA hsa-miR-195-5p VEGFA 0.00340440596007685 0.995685259335656 -0.114725328921871 0.904352276270392 miRNAWalker2_validate;miRTarBase;MirTarget -0.181624543409355 0.000381561947949573 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA -0.190333205251807 0.873282228777943 -0.114725328921871 0.904352276270392 miRanda;miRNATAP -0.137846678781097 0.00478526288616186 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA 0.0295106240253391 0.97471100218466 -0.114725328921871 0.904352276270392 miRanda -0.179432408970336 6.95568617152433e-05 NA NA NA hsa-miR-29a-3p VEGFA 0.144361548745149 0.928458118904984 -0.114725328921871 0.904352276270392 MirTarget -0.17079026405468 0.00573296636369365 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29b-2-5p VEGFA 0.0506576777608494 0.914446526694261 -0.114725328921871 0.904352276270392 MirTarget -0.280821422267245 0.000211600516233879 NA NA NA hsa-miR-29b-3p VEGFA 0.142303641653058 0.900102271992252 -0.114725328921871 0.904352276270392 miRNAWalker2_validate;miRTarBase;MirTarget -0.16053544503029 0.00905921871447091 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-29c-3p VEGFA -0.036782586594942 0.978186488964126 -0.114725328921871 0.904352276270392 miRNAWalker2_validate;MirTarget -0.264648504422189 2.62132710063096e-07 NA NA NA hsa-miR-342-3p VEGFA 0.151626922605026 0.867631856166764 -0.114725328921871 0.904352276270392 miRanda;miRNATAP -0.189890193502324 0.00167517321250592 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-374b-5p VEGFA -0.120825593958128 0.872556407127498 -0.114725328921871 0.904352276270392 MirTarget -0.221141411744261 0.0151262503227527 NA NA NA hsa-miR-424-5p VEGFA 0.16707104746762 0.861761331304308 -0.114725328921871 0.904352276270392 MirTarget -0.102477016192431 0.0470377274725433 NA NA NA hsa-miR-497-5p VEGFA 0.0254307781009064 0.960830371395482 -0.114725328921871 0.904352276270392 MirTarget -0.20501977308518 0.000143045715274148 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer hsa-miR-16-2-3p VEGFC -0.0660098106740605 0.907925706907323 -0.00316312329502733 0.993262322293605 MirTarget -0.523426860787708 4.20594096318382e-07 NA NA NA hsa-miR-195-3p VEGFC -0.0817091054958705 0.737669463151026 -0.00316312329502733 0.993262322293605 MirTarget;miRNATAP -0.182687043756397 0.0370380155405202 NA NA NA