miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-125b-5p MUC1 -1.94393269763542 2.78180543229264e-58 2.6031293995538 1.72038877386261e-27 miRNAWalker2_validate -0.230942035920558 0.000413325685003866 NA NA NA hsa-miR-145-5p MUC1 -2.62703571936687 7.64402900188551e-88 2.6031293995538 1.72038877386261e-27 miRNAWalker2_validate;miRTarBase -0.381041291185968 2.23197939904781e-11 24157791 MiR 145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1; MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3'UTRs; Importantly the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145 respectively; Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1 functioning as a tumor suppressor ovarian cancer hsa-miR-326 MUC1 -1.54449030848141 1.04703417845594e-17 2.6031293995538 1.72038877386261e-27 miRanda -0.332979150949343 2.83351674240864e-13 NA NA NA hsa-miR-335-5p MUC1 -2.61355235628987 2.6462884165886e-51 2.6031293995538 1.72038877386261e-27 miRNAWalker2_validate -0.327070840237111 6.22613212261101e-13 NA NA NA