miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-28-5p APC2 -0.430964830599964 2.67367257252925e-06 1.72078641102954 8.65364092042936e-19 mirMAP -0.301426627736638 0.00527080037286869 NA NA NA hsa-miR-15b-5p AXIN2 0.230566941413564 0.0824765001857479 0.113841868770703 0.752977397700815 miRTarBase;MirTarget;miRNATAP -0.445214007102522 0.000810754926318775 NA NA NA hsa-miR-16-2-3p AXIN2 -0.0336420826463706 0.805158952566973 0.113841868770703 0.752977397700815 mirMAP -0.637896819806337 6.99346379238779e-07 NA NA NA hsa-miR-16-5p AXIN2 -0.398577235179603 0.000101598495180191 0.113841868770703 0.752977397700815 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.492511513287746 0.00421170477125135 NA NA NA hsa-miR-195-3p AXIN2 -1.09375690196245 4.70092324819807e-09 0.113841868770703 0.752977397700815 mirMAP -0.313128484413814 0.000828518151480385 NA NA NA hsa-miR-26b-3p AXIN2 -1.25503731613309 4.45390890119649e-27 0.113841868770703 0.752977397700815 MirTarget -0.591476065389494 2.94301063245798e-05 NA NA NA hsa-miR-326 AXIN2 -1.881935132554 1.68087316863775e-21 0.113841868770703 0.752977397700815 miRanda -0.362520003418692 1.98590653589597e-05 NA NA NA hsa-miR-338-5p AXIN2 -0.221898432884726 0.252390988727086 0.113841868770703 0.752977397700815 miRNATAP -0.342154956032422 0.000172654921949776 NA NA NA hsa-miR-616-3p AXIN2 -0.699516741506971 1.82225985970292e-05 0.113841868770703 0.752977397700815 MirTarget -0.422833368838949 7.60561180413777e-05 NA NA NA hsa-miR-30e-3p CACYBP -1.20845647373031 3.10263633528203e-25 0.94781485840537 1.49218864384581e-19 MirTarget -0.346714737260252 1.1672915775241e-16 NA NA NA hsa-miR-15b-3p CAMK2A 0.238105490431193 0.0997721500357416 -0.327454379942138 0.356907439672438 mirMAP -0.441408376888264 0.000224916915481368 NA NA NA hsa-miR-21-3p CAMK2A -0.484219378716006 0.00299941098417659 -0.327454379942138 0.356907439672438 MirTarget -0.428695676613169 4.7255606363298e-05 NA NA NA hsa-miR-7-1-3p CAMK2A -0.569105143287799 1.85297665041424e-05 -0.327454379942138 0.356907439672438 MirTarget -0.357336167957049 0.00584245749670331 NA NA NA hsa-miR-10b-3p CAMK2B 2.77189254628215 2.26687582932628e-20 -3.79443915567367 4.19182064533683e-17 mirMAP -0.454957383759527 4.10184640844674e-09 NA NA NA hsa-miR-10b-5p CAMK2B 2.86931593037303 6.97409423207806e-23 -3.79443915567367 4.19182064533683e-17 miRNATAP -0.417096014841303 1.21569971542912e-08 NA NA NA hsa-miR-140-3p CAMK2B 0.546012239205329 4.84578261098777e-11 -3.79443915567367 4.19182064533683e-17 mirMAP -1.81411614260735 1.20529878439456e-11 NA NA NA hsa-miR-186-5p CAMK2B -0.060103391373687 0.535288717081205 -3.79443915567367 4.19182064533683e-17 miRNAWalker2_validate;miRNATAP -0.96780834136333 4.81115064147646e-05 NA NA NA hsa-miR-18a-5p CAMK2B 0.918028187958706 1.90229510425322e-05 -3.79443915567367 4.19182064533683e-17 mirMAP -0.422690423214241 5.82617560664156e-05 NA NA NA hsa-miR-34a-5p CAMK2B 1.03694231790865 5.74864019540594e-14 -3.79443915567367 4.19182064533683e-17 mirMAP -0.516635641071732 0.00134707229894061 NA NA NA hsa-miR-589-3p CAMK2B 1.16846704028095 5.88525574424201e-11 -3.79443915567367 4.19182064533683e-17 MirTarget -0.778879183962213 6.21351266377714e-10 NA NA NA hsa-miR-106b-5p CCND1 0.648901865047099 8.24870862047885e-09 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.430796355484411 1.07010119372681e-06 NA NA NA hsa-miR-15b-5p CCND1 0.230566941413564 0.0824765001857479 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.544455359613115 3.17021042565567e-13 NA NA NA hsa-miR-16-5p CCND1 -0.398577235179603 0.000101598495180191 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.309506657035983 0.00178218906910022 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-17-5p CCND1 0.698861147045461 2.43854106455398e-05 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.343463418912801 9.97512783987264e-09 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-186-5p CCND1 -0.060103391373687 0.535288717081205 -0.901747452525989 1.22363850855738e-05 mirMAP -0.315936974513477 0.00286438511586306 NA NA NA hsa-miR-19b-1-5p CCND1 -0.277804782598538 0.0783067794722916 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase -0.307712037252966 1.4364183273616e-06 NA NA NA hsa-miR-19b-3p CCND1 0.601279551368824 0.00016685097085251 -0.901747452525989 1.22363850855738e-05 miRNATAP -0.340975400639976 4.6454998539434e-08 NA NA NA hsa-miR-20a-5p CCND1 0.854326758727003 5.04256669663285e-07 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.332506713675419 1.04479750525145e-08 NA NA NA hsa-miR-340-5p CCND1 -0.00477614531381576 0.968502722773791 -0.901747452525989 1.22363850855738e-05 mirMAP -0.322810275002772 0.000125999869952101 NA NA NA hsa-miR-425-5p CCND1 0.585974239943864 2.23063410931402e-05 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate -0.385144136522737 9.38557217850495e-08 NA NA NA hsa-miR-92a-3p CCND1 0.212391012518195 0.134292268089997 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate -0.407898716180535 8.06773614790968e-09 NA NA NA hsa-miR-93-5p CCND1 1.39518349670953 2.84167728726712e-25 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.335918242999821 2.01286203755089e-06 NA NA NA hsa-miR-28-5p CCND2 -0.430964830599964 2.67367257252925e-06 0.356451160382274 0.0365641518216489 miRanda -0.482733599739849 7.0104175669049e-08 NA NA NA hsa-miR-616-5p CCND2 0.150569904638223 0.402836556304524 0.356451160382274 0.0365641518216489 mirMAP -0.315443515897926 3.35063962863299e-12 NA NA NA hsa-miR-22-3p CSNK2A1 -0.628561621952407 1.33755558015523e-09 0.311613292322925 6.17228757339028e-05 miRNAWalker2_validate -0.313593609077037 1.67312457705441e-19 NA NA NA hsa-miR-616-5p CTBP2 0.150569904638223 0.402836556304524 -0.39317918949034 0.0225071278697855 mirMAP -0.312610374730466 9.41444908463415e-12 NA NA NA hsa-miR-618 CTBP2 0.13539895350352 0.517145913114103 -0.39317918949034 0.0225071278697855 MirTarget;PITA -0.334800818337328 8.46589457931172e-17 NA NA NA hsa-miR-21-5p DAAM1 1.51084295924322 1.54551622173259e-34 -0.820319075229238 3.16122030911227e-05 miRNAWalker2_validate -0.578036099340168 1.45141919650478e-16 NA NA NA hsa-miR-92a-3p DAAM1 0.212391012518195 0.134292268089997 -0.820319075229238 3.16122030911227e-05 miRNATAP -0.329316230547128 1.24853835658816e-06 NA NA NA hsa-miR-18a-5p DAAM2 0.918028187958706 1.90229510425322e-05 -0.827336419502445 6.34713523969009e-05 miRNAWalker2_validate -0.316653308627821 4.58755922306922e-12 NA NA NA hsa-miR-193a-3p DAAM2 -0.117675551589896 0.309391958208578 -0.827336419502445 6.34713523969009e-05 miRanda -0.341711924634843 0.000104918704787674 NA NA NA hsa-miR-339-5p DAAM2 0.280589919878422 0.0355660282647215 -0.827336419502445 6.34713523969009e-05 miRanda -0.413344354790584 4.14363634293648e-08 NA NA NA hsa-miR-29a-3p DKK1 -0.856762511178136 4.65330336378459e-12 2.53841627649576 5.46380849566482e-06 miRNAWalker2_validate;miRTarBase -1.2101636118785 1.65540639532224e-08 NA NA NA hsa-miR-33a-3p DKK2 -0.683025859637737 1.01106097756419e-05 0.712159035258033 0.0313122411685687 mirMAP -0.398468507768241 0.000114088043705476 NA NA NA hsa-miR-361-5p DKK2 0.233202959858696 0.00961572812255327 0.712159035258033 0.0313122411685687 miRanda -0.656715068207467 0.000279767365569126 NA NA NA hsa-miR-374a-5p DKK2 0.016390363747302 0.869784217438621 0.712159035258033 0.0313122411685687 mirMAP -0.769067427863519 2.07316416575001e-06 NA NA NA hsa-miR-374b-5p DKK2 -0.307538028546424 0.0030079617545972 0.712159035258033 0.0313122411685687 mirMAP -0.802994528462122 2.17749870933731e-07 NA NA NA hsa-miR-455-5p DKK2 -0.270546034117157 0.0581320703577731 0.712159035258033 0.0313122411685687 miRanda -0.451655268783954 6.27129067973938e-05 NA NA NA hsa-miR-590-3p DKK2 -0.473167498047808 1.76652934637227e-05 0.712159035258033 0.0313122411685687 miRanda;mirMAP;miRNATAP -0.513273510317679 0.000433479835754034 NA NA NA hsa-miR-590-5p DKK2 -0.103355559980404 0.310027295317092 0.712159035258033 0.0313122411685687 miRanda -0.740681523990746 3.20086563969699e-06 NA NA NA hsa-miR-335-5p DKK4 -1.61347836513558 1.62757083289711e-19 1.45705615286137 0.00691061795938969 miRNAWalker2_validate -0.644570128381493 4.17056510573926e-06 NA NA NA hsa-miR-192-5p FZD1 -0.50188499512787 0.00344713341196035 -0.990655512447529 2.10933438723933e-07 miRNAWalker2_validate -0.45834591686859 3.50571643482894e-18 NA NA NA hsa-miR-107 FZD10 0.241662461253461 0.0170788899505389 1.18521144835282 0.000162683525329498 miRanda -0.685702388495361 6.84052605459746e-06 NA NA NA hsa-miR-15a-5p FZD10 0.349521211668244 0.000770735998804736 1.18521144835282 0.000162683525329498 miRNATAP -0.438409856444815 0.003263536270437 NA NA NA hsa-miR-455-3p FZD10 -1.3998033821095 5.72010709806871e-17 1.18521144835282 0.000162683525329498 PITA;miRNATAP -0.56334164531716 9.62780657403636e-11 NA NA NA hsa-miR-616-5p FZD2 0.150569904638223 0.402836556304524 0.407208233535239 0.0755693801228699 MirTarget -0.338122672996804 3.93516371913571e-08 NA NA NA hsa-miR-107 FZD3 0.241662461253461 0.0170788899505389 -0.431602727356764 0.0760494397449049 MirTarget;miRanda -0.328401554754828 0.0054060803500497 NA NA NA hsa-miR-30e-5p FZD3 -0.627815042856657 3.02205690184908e-10 -0.431602727356764 0.0760494397449049 MirTarget -0.313017658821363 0.00780190229296611 NA NA NA hsa-miR-361-5p FZD3 0.233202959858696 0.00961572812255327 -0.431602727356764 0.0760494397449049 miRanda;miRNATAP -0.462237677798914 0.000503688852257815 NA NA NA hsa-miR-374a-5p FZD3 0.016390363747302 0.869784217438621 -0.431602727356764 0.0760494397449049 mirMAP -0.515684566089532 1.54619533499017e-05 NA NA NA hsa-miR-374b-5p FZD3 -0.307538028546424 0.0030079617545972 -0.431602727356764 0.0760494397449049 mirMAP -0.314879611306133 0.00623855042899404 NA NA NA hsa-miR-106b-5p FZD4 0.648901865047099 8.24870862047885e-09 -0.346477770504521 0.0109747315056824 miRNATAP -0.36533974993703 1.76820222419432e-10 NA NA NA hsa-miR-21-5p FZD4 1.51084295924322 1.54551622173259e-34 -0.346477770504521 0.0109747315056824 mirMAP -0.321725677881532 3.91700387140416e-11 NA NA NA hsa-miR-324-3p FZD4 0.260348469146494 0.0506141704203545 -0.346477770504521 0.0109747315056824 miRNATAP -0.334268099452611 8.51422936858383e-12 NA NA NA hsa-miR-101-3p FZD6 -1.48176407980989 3.98950707385704e-31 0.589500198001939 0.00374127878510925 miRNAWalker2_validate;MirTarget -0.312670748498135 1.38907823475328e-05 NA NA NA hsa-miR-192-5p FZD7 -0.50188499512787 0.00344713341196035 -0.284533887049024 0.256557978536031 miRNAWalker2_validate -0.59446912784293 2.96084223842181e-18 NA NA NA hsa-miR-192-5p FZD9 -0.50188499512787 0.00344713341196035 -0.243785341556497 0.505341223526538 miRNATAP -0.306354280194544 0.00309846297489247 NA NA NA hsa-miR-93-5p JUN 1.39518349670953 2.84167728726712e-25 -1.59869078760734 2.2999762521731e-23 miRNAWalker2_validate -0.346015058492204 1.41571654493278e-09 NA NA NA hsa-let-7a-3p LEF1 -0.568717557554068 1.00947202557819e-07 2.65801616612257 2.07740338608884e-15 miRNATAP -0.639538499404186 4.40051133869843e-05 NA NA NA hsa-let-7b-3p LEF1 -1.21979213547786 5.84575581584603e-17 2.65801616612257 2.07740338608884e-15 miRNATAP -0.67397556538713 8.7442482981614e-10 NA NA NA hsa-miR-193b-3p LEF1 -0.166697207281748 0.272022543069482 2.65801616612257 2.07740338608884e-15 miRNAWalker2_validate -0.526045563134031 2.1073127312606e-06 NA NA NA hsa-miR-26a-5p LEF1 -0.963792031426845 1.83360999387345e-22 2.65801616612257 2.07740338608884e-15 miRNATAP -0.92158550768103 1.12073884009285e-08 NA NA NA hsa-miR-26b-5p LEF1 -1.10804856399744 4.14176110314282e-22 2.65801616612257 2.07740338608884e-15 miRNATAP -0.884181051978605 1.54988692872715e-10 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression colon cancer hsa-miR-326 LEF1 -1.881935132554 1.68087316863775e-21 2.65801616612257 2.07740338608884e-15 miRanda -0.385522349171234 2.19966753424773e-06 NA NA NA hsa-miR-33a-3p LEF1 -0.683025859637737 1.01106097756419e-05 2.65801616612257 2.07740338608884e-15 miRNATAP -0.438284453346108 5.04525548190065e-05 NA NA NA hsa-miR-455-5p LEF1 -0.270546034117157 0.0581320703577731 2.65801616612257 2.07740338608884e-15 miRanda -0.352774280915771 0.00297563964985378 NA NA NA hsa-miR-590-3p LEF1 -0.473167498047808 1.76652934637227e-05 2.65801616612257 2.07740338608884e-15 PITA;miRanda;mirMAP -0.434383824253157 0.00459273011390873 NA NA NA hsa-miR-7-1-3p LEF1 -0.569105143287799 1.85297665041424e-05 2.65801616612257 2.07740338608884e-15 mirMAP -0.451164571544049 0.000354486807433584 NA NA NA hsa-miR-221-3p MAPK10 1.12244756358612 3.48370308238012e-13 -1.09210524801043 3.20431274629696e-05 miRNATAP -0.345546531666561 1.95748420882985e-05 NA NA NA hsa-miR-590-5p MAPK10 -0.103355559980404 0.310027295317092 -1.09210524801043 3.20431274629696e-05 PITA;miRanda;miRNATAP -0.3693102549963 0.00397298728893767 NA NA NA hsa-miR-455-5p MMP7 -0.270546034117157 0.0581320703577731 -2.01551939575685 0.000378454690134257 miRanda -0.544946507919829 0.00528291990396599 NA NA NA hsa-miR-423-5p MYC 0.698807775906485 1.02195196334612e-11 -1.53204423111148 3.53987625613016e-10 miRNAWalker2_validate -0.328206409340035 0.00484551582134482 NA NA NA hsa-miR-455-5p NFATC1 -0.270546034117157 0.0581320703577731 -0.746396319507337 4.35096501526645e-05 miRanda -0.308343970820935 7.69222772176338e-07 NA NA NA hsa-miR-29a-5p NFATC2 -0.113555908626946 0.349622266470788 -1.87041062792181 1.43414339850833e-07 mirMAP;miRNATAP -0.583625441866098 5.86022160251471e-05 NA NA NA hsa-miR-30d-5p NFATC2 0.718283816348023 2.47422074061352e-08 -1.87041062792181 1.43414339850833e-07 MirTarget;mirMAP -0.429558488883224 0.00143308759494954 NA NA NA hsa-miR-24-3p NKD1 -0.257825594021966 0.00689742600215061 0.620599204750343 0.186026311634854 miRNAWalker2_validate -0.720087685375527 0.00289253594101155 NA NA NA hsa-miR-326 NKD1 -1.881935132554 1.68087316863775e-21 0.620599204750343 0.186026311634854 miRanda -0.457719741066059 3.39632756723267e-05 NA NA NA hsa-miR-330-5p NKD1 0.442231058604099 0.0053308560843808 0.620599204750343 0.186026311634854 miRanda;miRNATAP -0.798011342105715 1.8924968824333e-08 NA NA NA hsa-miR-340-5p NKD1 -0.00477614531381576 0.968502722773791 0.620599204750343 0.186026311634854 mirMAP -0.497913166437519 0.00902117405267133 NA NA NA hsa-miR-501-5p NKD1 1.15231083477882 2.98906150004088e-10 0.620599204750343 0.186026311634854 mirMAP -0.34471849546258 0.00491783464284498 NA NA NA hsa-let-7g-3p PLCB1 -1.14091000722297 8.32736018188759e-19 1.21243658346715 1.07604080006647e-07 miRNATAP -0.378100618457424 6.07423095960529e-06 NA NA NA hsa-miR-125b-5p PLCB1 -1.35767721102906 1.16564617395164e-18 1.21243658346715 1.07604080006647e-07 miRNATAP -0.431815972266254 3.97695185275028e-10 NA NA NA hsa-miR-139-5p PLCB1 -2.11299531796557 8.16407076415038e-28 1.21243658346715 1.07604080006647e-07 miRanda -0.443285019092489 3.47497230555386e-17 NA NA NA hsa-miR-192-3p PLCB4 -0.6401165114007 0.000266272092403814 0.84042226647322 0.000567827430148375 miRNATAP -0.557224111035552 1.21106381609851e-17 NA NA NA hsa-miR-374a-5p PLCB4 0.016390363747302 0.869784217438621 0.84042226647322 0.000567827430148375 mirMAP -0.40455507564767 0.00080732431795289 NA NA NA hsa-miR-374b-5p PLCB4 -0.307538028546424 0.0030079617545972 0.84042226647322 0.000567827430148375 mirMAP -0.47357360986951 4.03508572714821e-05 NA NA NA hsa-miR-590-3p PLCB4 -0.473167498047808 1.76652934637227e-05 0.84042226647322 0.000567827430148375 miRanda -0.405740740578056 0.000168632145756444 NA NA NA hsa-miR-17-5p PRICKLE1 0.698861147045461 2.43854106455398e-05 -1.74028095832004 2.56191738876965e-10 miRNAWalker2_validate -0.471288188738112 5.85304220563611e-09 NA NA NA hsa-miR-192-5p PRICKLE1 -0.50188499512787 0.00344713341196035 -1.74028095832004 2.56191738876965e-10 miRNAWalker2_validate -0.647920508976856 3.38291204645263e-17 NA NA NA hsa-miR-361-5p PRICKLE1 0.233202959858696 0.00961572812255327 -1.74028095832004 2.56191738876965e-10 miRanda -0.911449762777299 1.77245863720157e-09 NA NA NA hsa-miR-532-5p PRICKLE1 1.02729546510601 9.93318913966636e-16 -1.74028095832004 2.56191738876965e-10 miRNATAP -0.715708313801668 1.59405526679308e-12 NA NA NA hsa-miR-148a-3p PRICKLE2 -0.748702855596996 3.93313343865641e-07 -1.36375835552812 1.67599789165395e-08 MirTarget;miRNATAP -0.361824889511995 5.66694348602003e-06 NA NA NA hsa-miR-148a-5p PRICKLE2 -0.767626696027761 1.08359477494797e-06 -1.36375835552812 1.67599789165395e-08 mirMAP -0.346057768362087 3.65630739339723e-06 NA NA NA hsa-miR-148b-3p PRICKLE2 0.266862251671911 0.00185271302045935 -1.36375835552812 1.67599789165395e-08 MirTarget;miRNATAP -0.463580487018835 0.00102384966132943 NA NA NA hsa-miR-589-5p PRICKLE2 1.18593770505086 1.01781241960531e-22 -1.36375835552812 1.67599789165395e-08 MirTarget;miRNATAP -0.537211352042197 7.52017218056411e-09 NA NA NA hsa-miR-194-5p PRKCB -0.292530160992458 0.0996141384876663 -1.62067363753233 3.76201992658756e-13 miRNATAP -0.310861421038956 6.51903986219064e-07 NA NA NA hsa-miR-30d-5p PRKCB 0.718283816348023 2.47422074061352e-08 -1.62067363753233 3.76201992658756e-13 mirMAP -0.362125630736335 2.22146697946039e-05 NA NA NA hsa-miR-361-5p PRKCB 0.233202959858696 0.00961572812255327 -1.62067363753233 3.76201992658756e-13 MirTarget;miRanda;miRNATAP -0.424918272347972 0.000711090604030861 NA NA NA hsa-miR-589-5p PRKCB 1.18593770505086 1.01781241960531e-22 -1.62067363753233 3.76201992658756e-13 mirMAP -0.552773953594914 1.64276000301029e-10 NA NA NA hsa-miR-664a-3p PRKCB 0.485807855553031 0.000732553249798598 -1.62067363753233 3.76201992658756e-13 mirMAP -0.348212449855556 6.35284546408206e-06 NA NA NA hsa-miR-140-3p PRKX 0.546012239205329 4.84578261098777e-11 -0.240211607134995 0.240371070351319 mirMAP -0.414153706871003 0.000486275257531284 NA NA NA hsa-miR-148a-3p PRKX -0.748702855596996 3.93313343865641e-07 -0.240211607134995 0.240371070351319 MirTarget -0.590431480469924 2.08013051455884e-20 NA NA NA hsa-miR-23b-3p PRKX -0.530561587109023 5.43807206823652e-07 -0.240211607134995 0.240371070351319 mirMAP -0.336626794798551 0.000311507204483922 NA NA NA hsa-miR-374a-3p PRKX -0.207171354826929 0.0623494608399903 -0.240211607134995 0.240371070351319 mirMAP -0.334277813432835 0.000202864124975447 NA NA NA hsa-miR-125a-5p RAC3 -0.91219969372382 1.38256246489548e-07 0.670983769148776 0.00109278799508602 PITA -0.323616313906469 9.94727754352694e-09 NA NA NA hsa-miR-1301-3p SFRP1 1.12156714169769 4.22404125385203e-10 -4.14637823674297 1.04005427998815e-32 MirTarget -0.326166528078997 0.00113518434436241 NA NA NA hsa-miR-16-1-3p SFRP1 0.392360028038559 0.00112481918108198 -4.14637823674297 1.04005427998815e-32 MirTarget -0.71551742776429 2.38771391079108e-06 NA NA NA hsa-miR-192-3p SFRP1 -0.6401165114007 0.000266272092403814 -4.14637823674297 1.04005427998815e-32 MirTarget -0.424962367232444 4.17845072192868e-05 NA NA NA hsa-miR-501-5p SFRP1 1.15231083477882 2.98906150004088e-10 -4.14637823674297 1.04005427998815e-32 mirMAP -0.477662273757518 1.00728429943687e-06 NA NA NA hsa-miR-548b-3p SFRP1 -0.0203576084717134 0.930819503166956 -4.14637823674297 1.04005427998815e-32 mirMAP -0.432545827935783 3.67109378834241e-08 NA NA NA hsa-miR-548j-5p SFRP1 0.251239647701947 0.171361975450222 -4.14637823674297 1.04005427998815e-32 MirTarget -0.453370953209203 1.05214745425183e-05 NA NA NA hsa-miR-455-5p SFRP2 -0.270546034117157 0.0581320703577731 0.468120194073395 0.289027671938249 miRanda -0.795717260851726 9.71330692924213e-08 NA NA NA hsa-miR-144-5p SFRP4 -1.54604938792018 1.06886492586611e-10 2.13318024807939 8.83329524470029e-10 MirTarget -0.351626376323752 4.90563413861651e-07 NA NA NA hsa-miR-26b-5p SFRP4 -1.10804856399744 4.14176110314282e-22 2.13318024807939 8.83329524470029e-10 miRNAWalker2_validate -0.774813965686543 5.2927899458002e-08 NA NA NA hsa-miR-3607-3p SFRP4 -2.15518588554493 1.03390728226728e-23 2.13318024807939 8.83329524470029e-10 MirTarget -0.343276705360189 5.59321744727563e-06 NA NA NA hsa-miR-590-3p SOX17 -0.473167498047808 1.76652934637227e-05 0.0768945916400996 0.622559659278871 miRanda;miRNATAP -0.309598201550693 5.80979934015017e-06 NA NA NA hsa-miR-590-5p SOX17 -0.103355559980404 0.310027295317092 0.0768945916400996 0.622559659278871 miRanda -0.398203292429146 9.1083599709098e-08 NA NA NA hsa-miR-24-3p TCF7 -0.257825594021966 0.00689742600215061 0.316885181039244 0.149291794426295 miRNATAP -0.557846852041242 6.44555716594922e-07 NA NA NA hsa-miR-30e-3p TCF7 -1.20845647373031 3.10263633528203e-25 0.316885181039244 0.149291794426295 mirMAP -0.346228359167188 6.3617494517767e-05 NA NA NA hsa-miR-331-3p TCF7 -0.283974346994635 0.0373785411053202 0.316885181039244 0.149291794426295 MirTarget;miRNATAP -0.479855997763643 5.36153680989195e-10 NA NA NA hsa-miR-107 VANGL2 0.241662461253461 0.0170788899505389 -0.695002958600546 0.0292238308957975 miRanda -0.708132234132303 4.03206007205814e-06 NA NA NA hsa-miR-140-3p VANGL2 0.546012239205329 4.84578261098777e-11 -0.695002958600546 0.0292238308957975 PITA;miRNATAP -0.749116548016374 5.12318056320725e-05 NA NA NA hsa-miR-362-3p VANGL2 0.814007335895913 2.00108618836568e-09 -0.695002958600546 0.0292238308957975 PITA;miRanda;miRNATAP -0.330222176686103 0.00341929011907735 NA NA NA hsa-miR-378a-5p VANGL2 -1.58667444700188 3.19640857320504e-17 -0.695002958600546 0.0292238308957975 MirTarget -0.376638409057428 1.76672899983547e-06 NA NA NA hsa-miR-589-5p VANGL2 1.18593770505086 1.01781241960531e-22 -0.695002958600546 0.0292238308957975 mirMAP -0.401995112344914 0.001013418640154 NA NA NA hsa-miR-28-5p WIF1 -0.430964830599964 2.67367257252925e-06 0.556794941584025 0.11285363711586 miRanda -0.495201246744867 0.00804338317259052 NA NA NA hsa-miR-378a-3p WNT10A -1.1920055906972 3.23538871733634e-10 -0.699775326592301 0.014837769527789 MirTarget;miRNATAP -0.311876203963016 1.46588032688135e-05 NA NA NA hsa-miR-664a-3p WNT10A 0.485807855553031 0.000732553249798598 -0.699775326592301 0.014837769527789 mirMAP -0.334039889137342 0.000582315884836279 NA NA NA hsa-miR-362-3p WNT2 0.814007335895913 2.00108618836568e-09 -3.91913726472358 3.44531322240171e-22 miRanda -0.596906309855373 7.09333385741009e-05 NA NA NA hsa-miR-532-5p WNT2 1.02729546510601 9.93318913966636e-16 -3.91913726472358 3.44531322240171e-22 miRNATAP -1.17021689287712 1.95625819314329e-14 NA NA NA hsa-miR-548b-3p WNT2 -0.0203576084717134 0.930819503166956 -3.91913726472358 3.44531322240171e-22 MirTarget -0.502061495825289 1.54565101391317e-08 NA NA NA hsa-miR-616-5p WNT2B 0.150569904638223 0.402836556304524 0.919797388731247 8.84184321894967e-05 mirMAP -0.357146678596839 1.78631568677685e-08 NA NA NA hsa-miR-195-5p WNT3A -1.85907534356434 1.47434041676402e-22 1.98708616870099 1.63071643507271e-06 MirTarget;miRNATAP -0.344445023915739 0.000703711150128669 25174704;26573286 MicroRNA 195 acts as a tumor suppressor by directly targeting Wnt3a in HepG2 hepatocellular carcinoma cells; Luciferase reporter assay was used to determine whether Wnt3a was a target of miR-195; Furthermore Wnt3a was demonstrated to be directly targeted by miR-195; These findings suggest that miR-195 is key in regulating cell proliferation cell cycle and apoptosis through targeting Wnt3a;Eribulin upregulates miR 195 expression and downregulates Wnt3a expression in non basal like type of triple negative breast cancer cell MDA MB 231; The expression level of miR-195 targeting Wnt3a significantly decreased compared to the control in MDA-MB-231 whereas it significantly increased in HCC1143; These results showed that exposure to eribulin highly increased the expression of miR-195 while it decreased the expression of Wnt3a in non-basal-like type of TNBC ; liver cancer;breast cancer hsa-miR-27b-3p WNT3A -0.823491817819754 9.20935302746823e-14 1.98708616870099 1.63071643507271e-06 miRNATAP -0.548421477531898 0.00239496180403094 NA NA NA hsa-miR-335-5p WNT3A -1.61347836513558 1.62757083289711e-19 1.98708616870099 1.63071643507271e-06 mirMAP -0.466783584252119 1.77594430006242e-05 NA NA NA hsa-miR-107 WNT4 0.241662461253461 0.0170788899505389 -0.395843982979098 0.363792495355894 PITA;miRNATAP -1.20015521254906 8.09058681955679e-09 NA NA NA hsa-miR-185-5p WNT5B 0.480006257154717 6.35758891340152e-07 -1.13697207573161 0.000217274755514595 miRNAWalker2_validate -0.637058578135861 4.15131637965874e-05 NA NA NA hsa-miR-34a-5p WNT7B 1.03694231790865 5.74864019540594e-14 -2.49986156980565 3.55477150766295e-09 mirMAP -0.871435014929295 2.29802092991709e-09 NA NA NA hsa-miR-505-3p WNT7B -1.20027021591555 1.27927500175937e-13 -2.49986156980565 3.55477150766295e-09 miRNATAP -0.343304152336908 0.00653008300029439 NA NA NA