miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-139-5p ABCA1 0.647754756897662 2.1537830723695e-06 0.0188106659493208 0.834105815897059 miRanda -0.263708846602264 1.64525235081767e-25 NA NA NA hsa-miR-330-3p ABCA1 0.427388106938161 0.003004892844142 0.0188106659493208 0.834105815897059 miRNATAP -0.163384205726188 7.06328384068288e-12 NA NA NA hsa-miR-338-3p ABCA1 0.399637046793888 0.00344106432206527 0.0188106659493208 0.834105815897059 miRanda -0.196718710734153 1.20229597332922e-12 NA NA NA hsa-miR-338-5p ABCA1 0.424003687569646 0.00246415720301228 0.0188106659493208 0.834105815897059 mirMAP -0.117054605429546 3.36881431009158e-06 NA NA NA hsa-miR-490-3p ABCA1 0.834268051506887 5.26203010743174e-06 0.0188106659493208 0.834105815897059 miRanda -0.152513501674854 5.1131380348912e-16 NA NA NA hsa-miR-139-5p ABCA13 0.647754756897662 2.1537830723695e-06 -0.765367296823267 3.71773283982254e-06 miRanda -0.346693575583101 1.51408438401777e-10 NA NA NA hsa-miR-338-3p ABCA13 0.399637046793888 0.00344106432206527 -0.765367296823267 3.71773283982254e-06 miRanda -0.220564202234638 0.00016209309937452 NA NA NA hsa-miR-490-3p ABCA13 0.834268051506887 5.26203010743174e-06 -0.765367296823267 3.71773283982254e-06 miRanda -0.123159515618342 0.00213236756691269 NA NA NA hsa-miR-139-5p ABCB4 0.647754756897662 2.1537830723695e-06 -0.621982915533886 6.88004763327102e-13 miRanda -0.280344400080448 1.56455442308985e-23 NA NA NA hsa-miR-129-5p ABCD1 0.567133990117154 0.00116152215679873 -0.287905702942523 1.52642510267695e-06 MirTarget -0.142708978210509 3.50805818910266e-25 NA NA NA hsa-miR-330-3p ABHD4 0.427388106938161 0.003004892844142 0.0670651569756515 0.292158803798946 PITA;miRNATAP -0.107472968813457 4.73897140848721e-12 NA NA NA hsa-miR-338-3p ABHD4 0.399637046793888 0.00344106432206527 0.0670651569756515 0.292158803798946 miRanda -0.110083462994519 1.42435039770335e-09 NA NA NA hsa-miR-139-5p ABI3BP 0.647754756897662 2.1537830723695e-06 0.534795618369772 0.000505432877203198 miRanda -0.12386144604804 0.0141308338101574 NA NA NA hsa-miR-139-5p ACCS 0.647754756897662 2.1537830723695e-06 -0.406121604996939 0.00104818109059382 miRanda -0.151724590430253 0.000212237198119427 NA NA NA hsa-miR-129-5p ADAM12 0.567133990117154 0.00116152215679873 -1.04394410405497 1.19114934803866e-12 miRanda;mirMAP -0.177528935762411 3.50954524051505e-06 NA NA NA hsa-miR-139-5p ADAM12 0.647754756897662 2.1537830723695e-06 -1.04394410405497 1.19114934803866e-12 miRanda -0.303198930124896 5.76662396891947e-10 NA NA NA hsa-miR-338-3p ADAM12 0.399637046793888 0.00344106432206527 -1.04394410405497 1.19114934803866e-12 miRanda -0.161973854683175 0.00220324033086378 NA NA NA hsa-miR-338-3p ADAM17 0.399637046793888 0.00344106432206527 -0.120988369271791 0.0472306940455016 PITA;miRanda;miRNATAP -0.122198017386768 2.79501719664482e-11 26617808 MiR 338 3p inhibits the proliferation and migration of gastric cancer cells by targeting ADAM17; Moreover we identified A disintegrin and metalloproteinase 17 ADAM17 gene as potential target of miR-338-3p; Importantly ADAM17 rescued the miR-338-3p mediated inhibition of cell proliferation migration and invasion; Our study suggested that miR-338-3p is significantly decreased in gastric cancer and inhibits cell proliferation migration and invasion partially via the downregulation of ADAM17 gastric cancer hsa-miR-330-5p ADAM29 0.262932095995619 0.0465226565966542 0.971737537306818 2.57325325770359e-08 miRanda -0.116327380457055 0.047454817562136 NA NA NA hsa-miR-490-3p ADAM6 0.834268051506887 5.26203010743174e-06 -0.766123848506701 0.000800567678075958 miRanda -0.28662955489339 1.69110807935291e-07 NA NA NA hsa-miR-338-5p ADAMDEC1 0.424003687569646 0.00246415720301228 -1.48721732655127 2.73688662390031e-09 MirTarget -0.241230449643324 0.00255377221427763 NA NA NA hsa-miR-330-5p ADAMTS13 0.262932095995619 0.0465226565966542 0.188793636865761 0.0127430137090912 miRanda -0.105009915407517 1.62537663448871e-05 NA NA NA hsa-miR-490-3p ADAMTS20 0.834268051506887 5.26203010743174e-06 0.740747775163609 0.00388358523251637 miRanda -0.16956965549145 0.00631993844932782 NA NA NA hsa-miR-330-3p ADAMTS5 0.427388106938161 0.003004892844142 0.247127577081209 0.0171012547059892 miRNATAP -0.176275277836879 8.40532502400138e-09 NA NA NA hsa-miR-139-5p ADAMTS6 0.647754756897662 2.1537830723695e-06 -0.11823335399784 0.240230761835988 miRanda -0.168192201022118 2.00609908079817e-07 NA NA NA hsa-miR-330-3p ADAMTS6 0.427388106938161 0.003004892844142 -0.11823335399784 0.240230761835988 PITA;mirMAP -0.264534336703472 5.02192615950895e-20 NA NA NA hsa-miR-330-5p ADAMTS6 0.262932095995619 0.0465226565966542 -0.11823335399784 0.240230761835988 PITA;miRanda;miRNATAP -0.310019696425726 7.5802397344856e-23 NA NA NA hsa-miR-338-3p ADAMTS6 0.399637046793888 0.00344106432206527 -0.11823335399784 0.240230761835988 miRNATAP -0.211017373454454 7.91544341092361e-10 NA NA NA hsa-miR-129-5p ADAMTS7 0.567133990117154 0.00116152215679873 -0.766328671906749 1.52518550238978e-09 MirTarget -0.171252425499437 1.55483270742401e-07 NA NA NA hsa-miR-139-5p ADAMTS9 0.647754756897662 2.1537830723695e-06 0.106172409496749 0.315532193383009 miRanda -0.176188823562598 1.75466236569489e-07 NA NA NA hsa-miR-338-3p ADAMTSL1 0.399637046793888 0.00344106432206527 0.00560999289601072 0.967733239993523 miRanda -0.114889384571742 0.0187530767837288 NA NA NA hsa-miR-490-3p ADAMTSL4 0.834268051506887 5.26203010743174e-06 -0.586886893510174 2.16162879064325e-08 miRanda -0.106881766055503 2.82648402204344e-05 NA NA NA hsa-miR-338-5p ADM 0.424003687569646 0.00246415720301228 -0.511403284930167 0.000454310346881393 MirTarget;PITA;miRNATAP -0.142182586182358 0.00197823251391901 NA NA NA hsa-miR-330-5p ADM2 0.262932095995619 0.0465226565966542 -0.690071693181486 2.66769717356179e-07 mirMAP -0.12898031944219 0.00403085750938525 NA NA NA hsa-miR-490-3p AEN 0.834268051506887 5.26203010743174e-06 -0.53280054741687 3.68305662427594e-10 mirMAP -0.100599041213401 6.18247531027852e-07 NA NA NA hsa-miR-330-3p AFAP1 0.427388106938161 0.003004892844142 0.0736173116229875 0.322923431862358 mirMAP -0.104400716918635 3.75451244060469e-08 NA NA NA hsa-miR-139-5p AFAP1L1 0.647754756897662 2.1537830723695e-06 -0.687888848728107 4.83211832038628e-14 miRanda -0.173764709167451 7.60863055536119e-09 NA NA NA hsa-miR-129-5p AGER 0.567133990117154 0.00116152215679873 0.0526086831008383 0.583707454312023 MirTarget -0.114835136293542 2.12917724095939e-06 NA NA NA hsa-miR-139-5p AHR 0.647754756897662 2.1537830723695e-06 -0.154951600469041 0.143165136318282 miRanda -0.102228368045928 0.00309005097793624 NA NA NA hsa-miR-338-3p AIM1 0.399637046793888 0.00344106432206527 -0.762995234316628 3.66426189927437e-09 miRanda -0.161313137270458 0.000477622595354141 NA NA NA hsa-miR-338-3p AIM2 0.399637046793888 0.00344106432206527 0.11371309045478 0.31234143410858 miRanda -0.191912531130052 1.05026683058388e-06 NA NA NA hsa-miR-129-5p AK2 0.567133990117154 0.00116152215679873 -0.282715213855517 9.17117363489464e-06 miRanda -0.101951659234979 1.17363546190466e-13 NA NA NA hsa-miR-139-5p AKAP13 0.647754756897662 2.1537830723695e-06 -0.0854748245852885 0.142976880881264 miRanda -0.121872626923689 3.59119108527437e-18 NA NA NA hsa-miR-129-5p AKNAD1 0.567133990117154 0.00116152215679873 -0.783561490945404 1.46914071242113e-08 miRanda -0.138721616295706 0.000106431170776141 NA NA NA hsa-miR-330-3p ALDH1L2 0.427388106938161 0.003004892844142 0.249171231424119 0.00714127456675665 MirTarget;mirMAP -0.11423593463508 2.35922185718587e-05 NA NA NA hsa-miR-330-5p ALDH1L2 0.262932095995619 0.0465226565966542 0.249171231424119 0.00714127456675665 MirTarget;miRanda -0.106727688529375 0.000331730246837414 NA NA NA hsa-miR-485-3p ALDH1L2 0.530677478972608 0.00148549219838864 0.249171231424119 0.00714127456675665 mirMAP -0.126797127730376 4.28872754012216e-08 NA NA NA hsa-miR-129-5p ALDH3B1 0.567133990117154 0.00116152215679873 -0.29665458430385 0.000157044686733227 miRanda -0.105995419893649 6.24438641625674e-08 NA NA NA hsa-miR-139-5p ALOX5 0.647754756897662 2.1537830723695e-06 -0.344108748159848 0.00382845936094958 miRanda -0.251018706650228 7.31057650645163e-11 NA NA NA hsa-miR-490-3p ALPK2 0.834268051506887 5.26203010743174e-06 -0.934513293277587 5.47878500261081e-08 miRanda -0.151164561865379 0.000280031207735013 NA NA NA hsa-miR-139-5p AMMECR1 0.647754756897662 2.1537830723695e-06 -0.110861997069305 0.0201013947226924 miRanda -0.116065576680622 1.27386557388086e-15 NA NA NA hsa-miR-129-5p ANGPT2 0.567133990117154 0.00116152215679873 -0.973073130335976 3.11405321255298e-13 MirTarget;miRanda -0.318009570105921 2.19601545367872e-21 NA NA NA hsa-miR-138-5p ANGPT2 0.61608764992087 1.35200027885651e-05 -0.973073130335976 3.11405321255298e-13 MirTarget -0.292625041668636 1.45807993019987e-12 NA NA NA hsa-miR-330-5p ANKRD13B 0.262932095995619 0.0465226565966542 0.09350950710144 0.144667246095611 miRanda;miRNATAP -0.105092122040183 2.23859312305972e-08 NA NA NA hsa-miR-330-5p ANKS3 0.262932095995619 0.0465226565966542 0.0177595039128953 0.767497425535252 miRNATAP -0.117136617040571 1.07509980629221e-10 NA NA NA hsa-miR-330-5p ANKZF1 0.262932095995619 0.0465226565966542 0.0192154077536628 0.753150854749351 miRanda -0.141318068508843 8.0912798229904e-16 NA NA NA hsa-miR-138-1-3p ANO6 0.446369405595197 0.000598407910928167 -0.362525289302433 8.04209213730108e-06 MirTarget -0.127525194435574 4.60609578784408e-07 NA NA NA hsa-miR-138-5p ANO6 0.61608764992087 1.35200027885651e-05 -0.362525289302433 8.04209213730108e-06 MirTarget -0.222730538503581 1.67007991115467e-23 NA NA NA hsa-miR-485-3p ANO6 0.530677478972608 0.00148549219838864 -0.362525289302433 8.04209213730108e-06 MirTarget -0.115780378617627 1.94659515293483e-09 NA NA NA hsa-miR-129-5p ANTXR1 0.567133990117154 0.00116152215679873 -0.0553770587592091 0.431389181613128 miRanda;mirMAP -0.1052860541265 1.32737862922896e-14 NA NA NA hsa-miR-338-3p ANTXR1 0.399637046793888 0.00344106432206527 -0.0553770587592091 0.431389181613128 miRanda -0.167239971793899 2.4199046725644e-19 NA NA NA hsa-miR-129-5p ANTXR2 0.567133990117154 0.00116152215679873 -0.428282089812336 2.56588179242397e-07 miRanda;miRNATAP -0.115703785461674 1.95385363983146e-08 NA NA NA hsa-miR-490-3p ANTXR2 0.834268051506887 5.26203010743174e-06 -0.428282089812336 2.56588179242397e-07 PITA -0.114488175094125 3.24032912076255e-09 NA NA NA hsa-miR-338-3p ANXA1 0.399637046793888 0.00344106432206527 -1.30540192314469 7.48633585880266e-15 miRanda -0.125045053575546 0.0383370338271533 NA NA NA hsa-miR-139-5p APBB1IP 0.647754756897662 2.1537830723695e-06 -0.11820416507432 0.325138295970974 miRanda -0.220267783642667 9.73006906144365e-09 NA NA NA hsa-miR-139-5p APH1A 0.647754756897662 2.1537830723695e-06 -0.137178624352432 0.0050194201207489 miRanda -0.120481929253767 1.59359057904804e-47 NA NA NA hsa-miR-139-5p APOBEC3D 0.647754756897662 2.1537830723695e-06 -0.648661071093302 2.70989797706938e-10 miRanda -0.203833561312315 1.94079377958712e-09 NA NA NA hsa-miR-490-3p APOL1 0.834268051506887 5.26203010743174e-06 -0.597918465990711 2.88035728824421e-09 miRanda -0.138798703651907 8.04020563195387e-09 NA NA NA hsa-miR-139-5p APOL4 0.647754756897662 2.1537830723695e-06 -1.31040522981715 1.60414033674559e-13 mirMAP -0.503011635761292 5.34737975568652e-18 NA NA NA hsa-miR-139-5p AQP1 0.647754756897662 2.1537830723695e-06 -0.780048407206974 3.38392577742259e-05 miRanda -0.138855757855795 0.0252222020381109 NA NA NA hsa-miR-338-3p AR 0.399637046793888 0.00344106432206527 -0.150947949527158 0.364688679402706 miRanda -0.232732609491165 6.58321720952697e-05 NA NA NA hsa-miR-129-5p ARHGAP11A 0.567133990117154 0.00116152215679873 -1.03121102440995 2.93212073471912e-22 miRanda -0.13729690591246 9.8272707463971e-07 NA NA NA hsa-miR-139-5p ARHGAP18 0.647754756897662 2.1537830723695e-06 -0.463355729627355 2.90924093041791e-07 miRanda -0.205665331665122 1.66223720762813e-12 NA NA NA hsa-miR-338-3p ARHGAP18 0.399637046793888 0.00344106432206527 -0.463355729627355 2.90924093041791e-07 miRanda -0.139422232486625 9.6985607425859e-06 NA NA NA hsa-miR-338-5p ARHGAP18 0.424003687569646 0.00246415720301228 -0.463355729627355 2.90924093041791e-07 PITA;mirMAP -0.107072903141759 0.000159412711522508 NA NA NA hsa-miR-338-3p ARHGAP31 0.399637046793888 0.00344106432206527 0.107982403544605 0.170797697693312 miRanda -0.109592559699389 2.883883088725e-06 NA NA NA hsa-miR-138-5p ARHGAP42 0.61608764992087 1.35200027885651e-05 0.0716708840857936 0.38162071392574 MirTarget;miRNATAP -0.155911910712092 1.47303233575759e-10 NA NA NA hsa-miR-338-3p ARHGEF10L 0.399637046793888 0.00344106432206527 0.154120242078544 0.045806292174139 PITA;miRanda;miRNATAP -0.10476230766839 6.19427517571118e-06 NA NA NA hsa-miR-139-5p ARHGEF6 0.647754756897662 2.1537830723695e-06 0.118178025063133 0.113065210407388 miRanda -0.141744595915386 8.8928632613928e-13 NA NA NA hsa-miR-139-5p ARID3B 0.647754756897662 2.1537830723695e-06 -0.101335452315805 0.0314167337073368 miRanda -0.103048883851257 2.00444923520862e-12 NA NA NA hsa-miR-129-5p ARL11 0.567133990117154 0.00116152215679873 -0.294358550877964 0.00362864367827827 miRanda;mirMAP -0.143614532626943 2.2315666837623e-08 NA NA NA hsa-miR-490-3p ARL11 0.834268051506887 5.26203010743174e-06 -0.294358550877964 0.00362864367827827 miRanda -0.139461024478719 7.41365933737947e-09 NA NA NA hsa-miR-139-5p ARL6IP6 0.647754756897662 2.1537830723695e-06 -0.0515616970997659 0.292466498800558 miRanda -0.120146390598241 5.96697175461285e-20 NA NA NA hsa-miR-129-5p ARPC1B 0.567133990117154 0.00116152215679873 -0.332541605102117 0.000194392690170457 mirMAP -0.126179723966664 4.3952684727043e-09 NA NA NA hsa-miR-138-5p ARRDC3 0.61608764992087 1.35200027885651e-05 -0.119441275627876 0.0481493321948708 miRNATAP -0.136449410542342 2.6548341169657e-18 NA NA NA hsa-miR-330-5p ARVCF 0.262932095995619 0.0465226565966542 0.133739238881019 0.0189713722563656 MirTarget -0.10493343859142 1.05573435540254e-10 NA NA NA hsa-miR-330-5p ASF1B 0.262932095995619 0.0465226565966542 -1.40450845453835 8.05952499365077e-25 miRanda -0.218719069279431 3.63355248454117e-06 NA NA NA hsa-miR-490-3p ASF1B 0.834268051506887 5.26203010743174e-06 -1.40450845453835 8.05952499365077e-25 miRanda -0.24643061431861 2.79157674580179e-13 NA NA NA hsa-miR-129-5p ASPN 0.567133990117154 0.00116152215679873 -0.537818719517971 2.41650433352898e-05 miRanda -0.102064938728213 0.00188747921441354 NA NA NA hsa-miR-139-5p ASPN 0.647754756897662 2.1537830723695e-06 -0.537818719517971 2.41650433352898e-05 miRanda -0.174506980543958 3.51257488334319e-05 NA NA NA hsa-miR-330-5p ATAD2B 0.262932095995619 0.0465226565966542 -0.0689850013062943 0.176557202332977 PITA;miRanda -0.120728348567611 2.54607621082229e-16 NA NA NA hsa-miR-338-3p ATAD2B 0.399637046793888 0.00344106432206527 -0.0689850013062943 0.176557202332977 miRanda -0.110962319734145 1.8380372434883e-12 NA NA NA hsa-miR-139-5p ATF3 0.647754756897662 2.1537830723695e-06 -0.719621463985796 1.03831087785814e-09 miRanda -0.143410908741362 0.000205818376773652 NA NA NA hsa-miR-338-3p ATP10D 0.399637046793888 0.00344106432206527 -0.146625775805417 0.0189365758247455 MirTarget;miRanda -0.114027902005617 1.63432805019987e-08 NA NA NA hsa-miR-139-5p ATP6V0A2 0.647754756897662 2.1537830723695e-06 -0.13609956406506 0.00239118624180297 miRanda -0.103316858751501 2.17447447458594e-19 NA NA NA hsa-miR-338-3p ATP6V1B1 0.399637046793888 0.00344106432206527 -0.138482215850821 0.269446023656438 miRanda -0.1928584236111 1.06717333700004e-05 NA NA NA hsa-miR-139-5p B3GALNT2 0.647754756897662 2.1537830723695e-06 -0.262091150268414 2.20865079051134e-07 MirTarget;miRanda -0.110469491515152 1.68166444366238e-13 NA NA NA hsa-miR-330-3p BARD1 0.427388106938161 0.003004892844142 -0.464301339546407 0.000100997141542968 MirTarget;mirMAP -0.116765999558123 0.0012103978530526 NA NA NA hsa-miR-338-5p BARD1 0.424003687569646 0.00246415720301228 -0.464301339546407 0.000100997141542968 mirMAP -0.117461771641252 0.00183327400863109 NA NA NA hsa-miR-490-3p BATF2 0.834268051506887 5.26203010743174e-06 -0.480406539227501 4.43167548031324e-07 MirTarget;miRanda -0.157663765536427 3.01839583176092e-12 NA NA NA hsa-miR-129-5p BAZ1A 0.567133990117154 0.00116152215679873 -0.314224930441592 1.18235960525264e-05 miRanda -0.13670583229834 1.05417626377193e-16 NA NA NA hsa-miR-139-5p BAZ1A 0.647754756897662 2.1537830723695e-06 -0.314224930441592 1.18235960525264e-05 miRanda -0.202758750714643 4.44640336836594e-22 NA NA NA hsa-miR-330-5p BAZ1A 0.262932095995619 0.0465226565966542 -0.314224930441592 1.18235960525264e-05 miRanda -0.185469236032578 3.00794209089617e-18 NA NA NA hsa-miR-338-3p BAZ1A 0.399637046793888 0.00344106432206527 -0.314224930441592 1.18235960525264e-05 miRanda -0.157539376886215 5.64605617164293e-12 NA NA NA hsa-miR-129-5p BCHE 0.567133990117154 0.00116152215679873 0.0931115265343294 0.283670679548094 PITA;miRanda -0.125631498338198 3.19336704899872e-10 NA NA NA hsa-miR-139-5p BCHE 0.647754756897662 2.1537830723695e-06 0.0931115265343294 0.283670679548094 miRanda -0.11319151926714 1.33445118816029e-05 NA NA NA hsa-miR-129-5p BCL2L12 0.567133990117154 0.00116152215679873 -0.602219045315043 9.24157894006186e-10 miRanda -0.17141556637721 8.13956438574003e-12 NA NA NA hsa-miR-330-5p BCL3 0.262932095995619 0.0465226565966542 -0.490197469950192 1.07113822796176e-09 MirTarget;miRanda -0.109066772313574 3.84355134980216e-05 NA NA NA hsa-miR-330-5p BEND3 0.262932095995619 0.0465226565966542 -0.14612425845079 0.006328695707366 miRanda -0.102536025793785 1.55503614750255e-09 NA NA NA hsa-miR-330-5p BEND7 0.262932095995619 0.0465226565966542 0.120681063153017 0.051788530020181 miRanda -0.181868482931035 1.38001589743967e-23 NA NA NA hsa-miR-129-5p BEST3 0.567133990117154 0.00116152215679873 0.159515530818019 0.286587263516968 MirTarget;miRanda -0.18146675987535 1.12535955422274e-06 NA NA NA hsa-miR-490-3p BEST3 0.834268051506887 5.26203010743174e-06 0.159515530818019 0.286587263516968 miRanda -0.183462738171151 1.57825435001266e-07 NA NA NA hsa-miR-338-3p BIRC5 0.399637046793888 0.00344106432206527 -1.68113336679374 3.24380055936619e-20 miRanda -0.23627947977916 0.000387181292152547 NA NA NA hsa-miR-330-3p BMF 0.427388106938161 0.003004892844142 -0.429207608696316 1.2633548549993e-05 mirMAP -0.197547053388228 5.06666335182977e-12 NA NA NA hsa-miR-330-5p BMF 0.262932095995619 0.0465226565966542 -0.429207608696316 1.2633548549993e-05 mirMAP -0.228800269028477 2.83139486129474e-13 NA NA NA hsa-miR-139-5p BMP1 0.647754756897662 2.1537830723695e-06 -0.297830750099207 3.28896004201451e-07 miRanda -0.201852378655831 4.34992693720797e-34 NA NA NA hsa-miR-139-5p BNIP2 0.647754756897662 2.1537830723695e-06 -0.111842120573399 0.00824795269406598 miRanda -0.119345028577158 2.90568672571045e-28 NA NA NA hsa-miR-139-5p BOC 0.647754756897662 2.1537830723695e-06 -0.226333258668565 0.00884745120498795 miRanda -0.110698372797836 3.13252416316387e-05 NA NA NA hsa-miR-330-5p BOC 0.262932095995619 0.0465226565966542 -0.226333258668565 0.00884745120498795 miRanda -0.179809679750732 9.46291182097126e-12 NA NA NA hsa-miR-338-3p BOC 0.399637046793888 0.00344106432206527 -0.226333258668565 0.00884745120498795 miRanda -0.157144412418856 2.43286832447711e-08 NA NA NA hsa-miR-338-5p BOC 0.424003687569646 0.00246415720301228 -0.226333258668565 0.00884745120498795 MirTarget;PITA;miRNATAP -0.148739766402411 3.79550010213217e-09 NA NA NA hsa-miR-129-5p BRCA2 0.567133990117154 0.00116152215679873 -1.02877893656155 1.26446979656698e-17 miRanda;mirMAP -0.162477261986263 2.63982338756038e-07 NA NA NA hsa-miR-490-3p BRIP1 0.834268051506887 5.26203010743174e-06 -1.32168413454638 8.57591144910916e-19 miRanda -0.121830147790504 0.00106443387207588 NA NA NA hsa-miR-139-5p BST1 0.647754756897662 2.1537830723695e-06 -0.481104660964169 4.51801530355689e-07 miRanda -0.271252857800469 1.20173067080245e-18 NA NA NA hsa-miR-490-3p BST1 0.834268051506887 5.26203010743174e-06 -0.481104660964169 4.51801530355689e-07 miRanda -0.12522704855473 4.97494234993182e-08 NA NA NA hsa-miR-138-5p BTG1 0.61608764992087 1.35200027885651e-05 -0.184952403664406 0.00164056003094408 miRNATAP -0.125021304790807 8.59308691283892e-20 NA NA NA hsa-miR-330-3p BTG1 0.427388106938161 0.003004892844142 -0.184952403664406 0.00164056003094408 PITA;miRNATAP -0.147571937395504 2.33233603637244e-29 NA NA NA hsa-miR-338-3p BTG1 0.399637046793888 0.00344106432206527 -0.184952403664406 0.00164056003094408 miRanda -0.135428743418772 4.63086314915907e-18 NA NA NA hsa-miR-139-5p BTG3 0.647754756897662 2.1537830723695e-06 -0.426763549550951 3.22796083683951e-13 MirTarget;PITA;miRanda;miRNATAP -0.21500204252075 3.12314970211803e-37 NA NA NA hsa-miR-338-5p BTG3 0.424003687569646 0.00246415720301228 -0.426763549550951 3.22796083683951e-13 MirTarget;PITA;miRNATAP -0.112232740101867 4.6938349781729e-11 NA NA NA hsa-miR-129-5p BTN2A2 0.567133990117154 0.00116152215679873 -0.550941930351989 6.14392708492992e-14 miRanda -0.10634745250215 7.80851341971585e-09 NA NA NA hsa-miR-338-3p BTN2A2 0.399637046793888 0.00344106432206527 -0.550941930351989 6.14392708492992e-14 miRanda -0.157004405828347 5.09944712528241e-10 NA NA NA hsa-miR-490-3p BTN2A2 0.834268051506887 5.26203010743174e-06 -0.550941930351989 6.14392708492992e-14 miRanda -0.131472307248864 1.58141871962417e-14 NA NA NA hsa-miR-139-5p BTN3A1 0.647754756897662 2.1537830723695e-06 -0.282123857446487 2.04731301873556e-05 miRanda -0.135436565764161 6.82757828331775e-12 NA NA NA hsa-miR-139-5p BUB1 0.647754756897662 2.1537830723695e-06 -1.4351194337037 1.02179760833849e-20 miRanda -0.36081871787807 3.0472333231544e-12 NA NA NA hsa-miR-338-3p C15orf39 0.399637046793888 0.00344106432206527 0.128977413164001 0.0758644398756863 mirMAP -0.100047646890477 1.77877157493382e-05 NA NA NA hsa-miR-330-3p C16orf87 0.427388106938161 0.003004892844142 -0.10845158001981 0.0279392712204476 mirMAP -0.119425672195007 1.06199251404879e-19 NA NA NA hsa-miR-485-3p C16orf87 0.530677478972608 0.00148549219838864 -0.10845158001981 0.0279392712204476 mirMAP -0.103119858011237 8.65139883697638e-20 NA NA NA hsa-miR-330-3p C17orf53 0.427388106938161 0.003004892844142 -0.606238091921423 2.50173478808682e-14 miRNATAP -0.137649564596102 1.75665069877755e-08 NA NA NA hsa-miR-330-5p C1QTNF6 0.262932095995619 0.0465226565966542 -0.320652151333454 1.18875033445207e-05 miRanda -0.142089335296563 1.41314086311685e-09 NA NA NA hsa-miR-490-3p C1QTNF6 0.834268051506887 5.26203010743174e-06 -0.320652151333454 1.18875033445207e-05 miRanda -0.152822974383823 4.2847142140821e-20 NA NA NA hsa-miR-129-5p C1R 0.567133990117154 0.00116152215679873 -0.776345411944755 3.7521602168378e-09 MirTarget;mirMAP -0.175827964912975 1.10099947297902e-07 NA NA NA hsa-miR-129-5p C1S 0.567133990117154 0.00116152215679873 -0.574449604802021 3.23954886378208e-06 MirTarget -0.121618270946388 8.92264358901396e-05 NA NA NA hsa-miR-330-5p C1orf106 0.262932095995619 0.0465226565966542 -0.174753916067083 0.0969463820190738 miRNATAP -0.189993978832519 1.89439656883477e-08 NA NA NA hsa-miR-129-5p C2 0.567133990117154 0.00116152215679873 -0.513212144119244 3.20255701339617e-05 miRanda -0.157187332390458 5.41424714815895e-07 NA NA NA hsa-miR-330-3p C2orf68 0.427388106938161 0.003004892844142 -0.0418991697199598 0.40454289262019 mirMAP -0.106643841313076 3.07533404834427e-18 NA NA NA hsa-miR-129-5p C5AR1 0.567133990117154 0.00116152215679873 -0.403758060568815 0.00179776261477902 miRanda -0.165720509365835 3.67945554387315e-07 NA NA NA hsa-miR-129-5p CA12 0.567133990117154 0.00116152215679873 -0.111303190460822 0.461483115950762 miRanda;mirMAP -0.114223428308507 0.00278167091404503 NA NA NA hsa-miR-138-5p CA3 0.61608764992087 1.35200027885651e-05 -1.27071401620038 5.5913267800272e-13 MirTarget -0.26952646321806 1.2336280691904e-06 NA NA NA hsa-miR-129-5p CACNA2D4 0.567133990117154 0.00116152215679873 -0.124667249111743 0.223762782279168 miRanda;mirMAP -0.155084059913391 2.17295374821659e-09 NA NA NA hsa-miR-330-3p CACNG4 0.427388106938161 0.003004892844142 0.0565977417868204 0.657305628641464 mirMAP -0.190990009831805 1.45198655589652e-07 NA NA NA hsa-miR-425-3p CACNG4 0.173302979693283 0.0801548384038341 0.0565977417868204 0.657305628641464 mirMAP -0.45905632171106 1.88987623289699e-18 NA NA NA hsa-miR-129-5p CALD1 0.567133990117154 0.00116152215679873 -0.385744127416833 8.93995326034798e-08 miRanda -0.108759213319541 1.21732953309098e-11 NA NA NA hsa-miR-139-5p CALD1 0.647754756897662 2.1537830723695e-06 -0.385744127416833 8.93995326034798e-08 miRanda -0.199918112805853 3.89116590336544e-23 NA NA NA hsa-miR-338-3p CALD1 0.399637046793888 0.00344106432206527 -0.385744127416833 8.93995326034798e-08 miRanda -0.15510125855943 1.85408617236225e-12 NA NA NA hsa-miR-338-5p CALD1 0.424003687569646 0.00246415720301228 -0.385744127416833 8.93995326034798e-08 PITA;miRNATAP -0.103939315285829 1.94167053605968e-07 NA NA NA hsa-miR-490-3p CALD1 0.834268051506887 5.26203010743174e-06 -0.385744127416833 8.93995326034798e-08 miRanda -0.120914328689842 6.13267964411697e-16 NA NA NA hsa-miR-139-5p CAPG 0.647754756897662 2.1537830723695e-06 -0.506439658164192 3.79086634892301e-05 miRanda -0.227282539946509 1.14939234930176e-08 NA NA NA hsa-miR-490-3p CARD16 0.834268051506887 5.26203010743174e-06 -0.855500116997693 3.42003053069781e-10 miRanda -0.201362124537143 9.85446147539062e-10 NA NA NA hsa-miR-138-1-3p CARD8 0.446369405595197 0.000598407910928167 -0.159808313294074 0.00817673426989705 MirTarget -0.108451456860259 5.61141647339367e-10 NA NA NA hsa-miR-129-5p CASP1 0.567133990117154 0.00116152215679873 -0.498266724086122 4.52530166466811e-06 miRanda -0.155842780545713 1.50308032877502e-08 NA NA NA hsa-miR-139-5p CASP1 0.647754756897662 2.1537830723695e-06 -0.498266724086122 4.52530166466811e-06 miRanda -0.345605845912303 8.08501261020161e-24 NA NA NA hsa-miR-490-3p CASP1 0.834268051506887 5.26203010743174e-06 -0.498266724086122 4.52530166466811e-06 miRanda -0.165903962860199 1.21815538353042e-10 NA NA NA hsa-miR-338-3p CASP2 0.399637046793888 0.00344106432206527 -0.345708591418149 2.86193876699208e-10 PITA -0.148591933065949 6.51225662722387e-19 NA NA NA hsa-miR-138-5p CASP3 0.61608764992087 1.35200027885651e-05 -0.262751412479426 2.56855295665512e-06 miRNAWalker2_validate;miRTarBase -0.113189968294872 3.60467356853659e-14 NA NA NA hsa-miR-139-5p CASP3 0.647754756897662 2.1537830723695e-06 -0.262751412479426 2.56855295665512e-06 miRanda -0.14903095658868 1.69348733053664e-21 NA NA NA hsa-miR-139-5p CASP4 0.647754756897662 2.1537830723695e-06 -0.729486831140248 2.86524482704498e-13 miRanda -0.345091617425972 3.52937451667932e-27 NA NA NA hsa-miR-129-5p CASP6 0.567133990117154 0.00116152215679873 -0.339809506908869 1.57352977415494e-06 MirTarget;miRanda -0.125127819729221 2.27853977473712e-12 NA NA NA hsa-miR-138-5p CASP7 0.61608764992087 1.35200027885651e-05 -0.330891851472554 2.19049833744449e-07 MirTarget -0.126194182155455 4.03886338228774e-11 NA NA NA hsa-miR-129-5p CASP8 0.567133990117154 0.00116152215679873 -0.546774650946584 3.45072924958533e-10 miRanda -0.121355359480355 5.2366688422782e-08 NA NA NA hsa-miR-490-3p CASP8 0.834268051506887 5.26203010743174e-06 -0.546774650946584 3.45072924958533e-10 miRanda -0.119572674587039 1.12289344974493e-08 NA NA NA hsa-miR-129-5p CASZ1 0.567133990117154 0.00116152215679873 -0.0601215020409915 0.599142890192472 miRNATAP -0.124074023649691 1.64231843713717e-05 NA NA NA hsa-miR-139-5p CAV2 0.647754756897662 2.1537830723695e-06 -0.443631337308644 9.96159787092773e-07 miRanda -0.10656339750402 0.00031877654743854 NA NA NA hsa-miR-330-3p CBLB 0.427388106938161 0.003004892844142 0.0670728385065797 0.332908868526853 PITA;mirMAP -0.123143851885456 2.07042632909313e-10 NA NA NA hsa-miR-330-5p CBX2 0.262932095995619 0.0465226565966542 -0.576976611077839 6.41977541080135e-08 miRanda -0.280826817718058 2.58252880104389e-16 NA NA NA hsa-miR-338-3p CBX2 0.399637046793888 0.00344106432206527 -0.576976611077839 6.41977541080135e-08 mirMAP -0.24755788063767 1.54499638374817e-11 NA NA NA hsa-miR-139-5p CBX3 0.647754756897662 2.1537830723695e-06 -0.177842492128226 0.000705235764931772 miRanda -0.109306118769868 2.68617988891121e-23 NA NA NA hsa-miR-129-5p CCDC102B 0.567133990117154 0.00116152215679873 -0.126536589835882 0.0134110296805357 miRanda -0.109301345975679 1.55416000721835e-20 NA NA NA hsa-miR-330-5p CCDC120 0.262932095995619 0.0465226565966542 0.206854162621814 0.00270973763045397 miRanda -0.167213491925524 2.85294545972742e-15 NA NA NA hsa-miR-330-5p CCDC130 0.262932095995619 0.0465226565966542 -0.115910383087289 0.0270197319695504 miRanda -0.119185202833318 3.90014032571734e-16 NA NA NA hsa-miR-139-5p CCDC146 0.647754756897662 2.1537830723695e-06 -0.105332246837767 0.285559479804322 miRanda -0.184407326291264 5.6707668824197e-09 NA NA NA hsa-miR-129-5p CCDC150 0.567133990117154 0.00116152215679873 -0.72090216336988 6.13337016378819e-12 miRanda -0.131935037188581 1.20188270247032e-06 NA NA NA hsa-miR-129-5p CCDC18 0.567133990117154 0.00116152215679873 -0.842490307381698 7.6637151605661e-15 MirTarget -0.143889943507914 3.63501376696811e-07 NA NA NA hsa-miR-139-5p CCDC57 0.647754756897662 2.1537830723695e-06 -0.0962996927146937 0.13523073565353 miRanda -0.109192022310059 6.89307034026674e-08 NA NA NA hsa-miR-330-5p CCDC84 0.262932095995619 0.0465226565966542 0.0180528066217276 0.800534002148087 miRanda -0.1514987224357 3.74496217731041e-11 NA NA NA hsa-miR-139-5p CCL8 0.647754756897662 2.1537830723695e-06 -0.206024260811105 0.329190673348237 miRanda -0.282021179314873 5.06377659375762e-05 NA NA NA hsa-miR-129-5p CCNA2 0.567133990117154 0.00116152215679873 -1.13046163382069 6.27502244010349e-22 miRanda -0.1950549250526 2.32918092265595e-10 NA NA NA hsa-miR-139-5p CCNB1 0.647754756897662 2.1537830723695e-06 -0.84976221863877 1.34547967203384e-21 miRanda -0.158522988130583 1.297334982042e-07 NA NA NA hsa-miR-330-3p CCND1 0.427388106938161 0.003004892844142 -0.517304800763465 1.04046594178981e-06 mirMAP -0.156757729272097 1.33987981854083e-07 NA NA NA hsa-miR-338-3p CCND1 0.399637046793888 0.00344106432206527 -0.517304800763465 1.04046594178981e-06 miRNAWalker2_validate;miRTarBase;miRanda -0.138060683824931 7.24806702911648e-05 NA NA NA hsa-miR-490-3p CCND1 0.834268051506887 5.26203010743174e-06 -0.517304800763465 1.04046594178981e-06 miRanda -0.131117175699242 2.90415525218072e-08 24440705 MicroRNA 490 3p inhibits proliferation of A549 lung cancer cells by targeting CCND1; We also found that forced expression of miR-490-3P decreased both mRNA and protein levels of CCND1 which plays a key role in G1/S phase transition; In addition the dual-luciferase reporter assays indicated that miR-490-3P directly targets CCND1 through binding its 3'UTR lung cancer hsa-miR-129-5p CCND2 0.567133990117154 0.00116152215679873 -0.278072058804779 0.00230941164668829 mirMAP -0.105272286982926 4.44505393807218e-07 NA NA NA hsa-miR-330-3p CCNJ 0.427388106938161 0.003004892844142 -0.0389526035961101 0.444862190729241 mirMAP -0.121849837003202 8.56286228473038e-19 NA NA NA hsa-miR-129-5p CCR1 0.567133990117154 0.00116152215679873 -0.274278251205972 0.0195461213372693 miRanda -0.11293988750021 0.000142932096966932 NA NA NA hsa-miR-338-5p CCR2 0.424003687569646 0.00246415720301228 -0.918588625309698 5.58290350913312e-07 mirMAP -0.169064126434514 0.00386397566341185 NA NA NA hsa-miR-139-5p CD163 0.647754756897662 2.1537830723695e-06 -1.1631048295549 2.93049985655875e-08 miRanda -0.610726857515977 9.63983752581929e-20 NA NA NA hsa-miR-139-5p CD164 0.647754756897662 2.1537830723695e-06 -0.156370978955255 0.00867640253972495 MirTarget;miRanda -0.113333938504846 7.96613509991605e-13 NA NA NA hsa-miR-129-5p CD1D 0.567133990117154 0.00116152215679873 -0.216937786555534 0.0580816782229216 miRanda -0.221975914988067 8.77405892176193e-15 NA NA NA hsa-miR-490-3p CD1D 0.834268051506887 5.26203010743174e-06 -0.216937786555534 0.0580816782229216 miRanda -0.201687520024915 7.50488802044649e-14 NA NA NA hsa-miR-129-5p CD209 0.567133990117154 0.00116152215679873 0.00198490539257912 0.990911879706078 miRanda -0.194459794019937 1.16879092980024e-05 NA NA NA hsa-miR-139-5p CD209 0.647754756897662 2.1537830723695e-06 0.00198490539257912 0.990911879706078 PITA;miRanda -0.166007771520943 0.0038675237278752 NA NA NA hsa-miR-330-3p CD209 0.427388106938161 0.003004892844142 0.00198490539257912 0.990911879706078 mirMAP -0.161318367215367 0.00217989348265557 NA NA NA hsa-miR-330-5p CD209 0.262932095995619 0.0465226565966542 0.00198490539257912 0.990911879706078 miRanda -0.158555088267987 0.0061256435384666 NA NA NA hsa-miR-330-3p CD276 0.427388106938161 0.003004892844142 -0.460031392457725 1.14859333750124e-10 mirMAP -0.117221338639073 1.24408404474415e-09 NA NA NA hsa-miR-330-5p CD276 0.262932095995619 0.0465226565966542 -0.460031392457725 1.14859333750124e-10 miRanda -0.110152199219768 2.2887414561088e-07 NA NA NA hsa-miR-338-3p CD276 0.399637046793888 0.00344106432206527 -0.460031392457725 1.14859333750124e-10 miRanda -0.183490757323008 1.09756250509587e-16 NA NA NA hsa-miR-338-5p CD28 0.424003687569646 0.00246415720301228 -0.558311533109354 0.000264571901223651 mirMAP;miRNATAP -0.111420731462115 0.0216432879710665 NA NA NA hsa-miR-139-5p CD302 0.647754756897662 2.1537830723695e-06 -0.27962018231613 0.00112239298684869 miRanda -0.139154494860837 2.34640241299273e-07 NA NA NA hsa-miR-129-5p CD36 0.567133990117154 0.00116152215679873 -0.200508230148761 0.180770200601982 miRanda -0.15705027333518 3.90191446322918e-05 NA NA NA hsa-miR-129-5p CD3E 0.567133990117154 0.00116152215679873 -0.945980615264257 1.52753211671932e-07 miRanda -0.133104371883132 0.00435272910041685 NA NA NA hsa-miR-490-3p CD3E 0.834268051506887 5.26203010743174e-06 -0.945980615264257 1.52753211671932e-07 miRanda -0.141772291734197 0.0012244943913532 NA NA NA hsa-miR-129-5p CD4 0.567133990117154 0.00116152215679873 -0.297394398083664 0.001175686752255 MirTarget -0.126745859081178 6.61895428273906e-09 NA NA NA hsa-miR-138-5p CD44 0.61608764992087 1.35200027885651e-05 -0.454265310281485 0.00121510157685102 MirTarget -0.363787988084945 3.0607119194613e-19 NA NA NA hsa-miR-490-3p CD63 0.834268051506887 5.26203010743174e-06 -0.288640947967322 9.01548567203632e-05 PITA;miRanda;miRNATAP -0.112653341355621 1.87043244522758e-16 NA NA NA hsa-miR-338-3p CD69 0.399637046793888 0.00344106432206527 -0.794295735746158 1.31262110029833e-06 miRanda -0.192092162478562 0.000986833824428852 NA NA NA hsa-miR-138-5p CD7 0.61608764992087 1.35200027885651e-05 -0.565636886892614 4.17985972756524e-06 mirMAP -0.155395922543528 4.83498645280521e-05 NA NA NA hsa-miR-129-5p CD72 0.567133990117154 0.00116152215679873 -0.300613491856478 0.00116773444918838 miRanda -0.139870445077655 2.62548674342087e-09 NA NA NA hsa-miR-490-3p CD84 0.834268051506887 5.26203010743174e-06 -0.195130752109874 0.153873055060855 miRanda -0.108204203615233 0.000962531055144856 NA NA NA hsa-miR-129-5p CD93 0.567133990117154 0.00116152215679873 -0.974726675983549 3.04076842126384e-15 MirTarget;miRanda -0.23931163583054 1.26395584806479e-14 NA NA NA hsa-miR-338-3p CD93 0.399637046793888 0.00344106432206527 -0.974726675983549 3.04076842126384e-15 mirMAP -0.374760417364572 7.82123910115113e-19 NA NA NA hsa-miR-485-3p CD93 0.530677478972608 0.00148549219838864 -0.974726675983549 3.04076842126384e-15 mirMAP -0.232103709722229 2.31701418549707e-13 NA NA NA hsa-miR-490-3p CD93 0.834268051506887 5.26203010743174e-06 -0.974726675983549 3.04076842126384e-15 mirMAP -0.261363467058706 1.46166543310023e-19 NA NA NA hsa-miR-129-5p CDCA2 0.567133990117154 0.00116152215679873 -1.50501411885487 5.26619518367056e-24 miRanda -0.237899580125391 1.61373130675737e-09 NA NA NA hsa-miR-139-5p CDCA7 0.647754756897662 2.1537830723695e-06 -0.568653806280932 1.51192072274824e-07 miRanda -0.287353658962981 1.65983210561943e-16 NA NA NA hsa-miR-129-5p CDCA7L 0.567133990117154 0.00116152215679873 -0.50549967315616 9.5310102859766e-07 miRanda;mirMAP -0.142423023339523 5.41142349002345e-08 NA NA NA hsa-miR-139-5p CDCA7L 0.647754756897662 2.1537830723695e-06 -0.50549967315616 9.5310102859766e-07 miRanda -0.178366287330944 1.29315535213432e-07 NA NA NA hsa-miR-139-5p CDCA8 0.647754756897662 2.1537830723695e-06 -1.31241668205155 1.12574681273778e-24 miRanda -0.301216148689265 3.95982974360746e-12 NA NA NA hsa-miR-338-5p CDCA8 0.424003687569646 0.00246415720301228 -1.31241668205155 1.12574681273778e-24 miRNATAP -0.158274999143075 0.000178266787951974 NA NA NA hsa-miR-129-5p CDCP1 0.567133990117154 0.00116152215679873 -0.510024355135388 5.60069380157114e-06 miRanda;mirMAP -0.144983203570309 4.61864146823022e-07 NA NA NA hsa-miR-139-5p CDH11 0.647754756897662 2.1537830723695e-06 -0.312004352619456 8.34060604537879e-06 miRanda -0.157661284023747 2.69518002099809e-15 NA NA NA hsa-miR-129-5p CDH15 0.567133990117154 0.00116152215679873 -0.185686121828863 0.397503313140937 MirTarget -0.159950589686983 0.00444567626281306 NA NA NA hsa-miR-485-3p CDH15 0.530677478972608 0.00148549219838864 -0.185686121828863 0.397503313140937 MirTarget -0.229682029751283 5.57130415628119e-05 NA NA NA hsa-miR-129-5p CDK1 0.567133990117154 0.00116152215679873 -1.30941007869762 3.57320278436402e-20 miRanda -0.209849987345076 1.90548673773584e-08 NA NA NA hsa-miR-139-5p CDK1 0.647754756897662 2.1537830723695e-06 -1.30941007869762 3.57320278436402e-20 miRanda -0.277601664216134 7.73143308262527e-09 NA NA NA hsa-miR-330-3p CDK1 0.427388106938161 0.003004892844142 -1.30941007869762 3.57320278436402e-20 MirTarget;miRNATAP -0.233546765096921 1.2423877231383e-07 NA NA NA hsa-miR-490-3p CDK1 0.834268051506887 5.26203010743174e-06 -1.30941007869762 3.57320278436402e-20 miRanda -0.199568686052587 1.30283346189843e-08 NA NA NA hsa-miR-490-3p CDK2 0.834268051506887 5.26203010743174e-06 -0.813366814153217 5.60398748525108e-23 miRanda -0.197884061603562 5.32644876787653e-25 NA NA NA hsa-miR-129-5p CDK6 0.567133990117154 0.00116152215679873 -0.514594252893815 5.86679673505726e-06 miRNAWalker2_validate -0.103420012068894 0.00024955678235129 24055727 Interestingly we showed that cyclin dependent kinase 6 CDK6 a cell cycle-associated protein involved in G1-S transition was a target of miR-129 gastric cancer hsa-miR-338-3p CDK6 0.399637046793888 0.00344106432206527 -0.514594252893815 5.86679673505726e-06 mirMAP -0.123780088353193 0.00144999386822314 NA NA NA hsa-miR-330-3p CDKN2B 0.427388106938161 0.003004892844142 0.254500650034011 0.0580107490431326 mirMAP;miRNATAP -0.170911889979298 1.82835015783354e-05 NA NA NA hsa-miR-129-5p CDKN2C 0.567133990117154 0.00116152215679873 -0.898221520592162 6.40702861965796e-16 miRanda -0.186505554250998 3.78408526778196e-11 NA NA NA hsa-miR-330-5p CEACAM19 0.262932095995619 0.0465226565966542 -0.0249547857044077 0.79081444823975 miRanda -0.16366272841528 9.69982888220534e-08 NA NA NA hsa-miR-138-5p CEBPA 0.61608764992087 1.35200027885651e-05 -0.225572181260874 0.0334607671491343 miRNAWalker2_validate -0.133070638427317 3.21414445973993e-05 NA NA NA hsa-miR-139-5p CEBPB 0.647754756897662 2.1537830723695e-06 -0.153622764992198 0.0762423547417911 miRanda -0.119339036616047 1.28860179751145e-05 NA NA NA hsa-miR-139-5p CELSR1 0.647754756897662 2.1537830723695e-06 -0.923774910454781 7.94870357177759e-09 miRanda -0.438442437466357 3.86495054308846e-17 NA NA NA hsa-miR-129-5p CENPF 0.567133990117154 0.00116152215679873 -1.38908509063487 3.23663204320061e-21 miRanda -0.144246569258603 0.000196771003147801 NA NA NA hsa-miR-139-5p CENPF 0.647754756897662 2.1537830723695e-06 -1.38908509063487 3.23663204320061e-21 miRanda -0.267131844641817 7.08419226550948e-08 NA NA NA hsa-miR-338-5p CENPF 0.424003687569646 0.00246415720301228 -1.38908509063487 3.23663204320061e-21 MirTarget -0.205309269465316 1.66608071963926e-05 NA NA NA hsa-miR-330-5p CENPT 0.262932095995619 0.0465226565966542 0.0497971742934391 0.388432474355554 miRanda -0.122628493364118 3.2674974323313e-14 NA NA NA hsa-miR-139-5p CENPW 0.647754756897662 2.1537830723695e-06 -0.705254694214253 6.57914174886302e-15 miRanda -0.170031934323305 2.17923525024506e-08 NA NA NA hsa-miR-330-5p CENPW 0.262932095995619 0.0465226565966542 -0.705254694214253 6.57914174886302e-15 miRanda -0.145422387653321 2.1632990518415e-06 NA NA NA hsa-miR-338-3p CENPW 0.399637046793888 0.00344106432206527 -0.705254694214253 6.57914174886302e-15 miRanda -0.11824143481383 0.00029693455907277 NA NA NA hsa-miR-338-3p CEP135 0.399637046793888 0.00344106432206527 -0.646158049312055 2.21242212285599e-19 miRanda -0.109095780358119 2.02129842340907e-05 NA NA NA hsa-miR-129-5p CEP152 0.567133990117154 0.00116152215679873 -0.617354680303919 6.18653770208071e-15 miRanda -0.121282332708787 3.01488298791354e-09 NA NA NA hsa-miR-129-5p CEP55 0.567133990117154 0.00116152215679873 -1.54905960452154 6.22351717730114e-23 miRanda -0.30480903398964 1.29202112916463e-13 NA NA NA hsa-miR-485-3p CHD7 0.530677478972608 0.00148549219838864 0.0362484916166279 0.677413963407218 miRNATAP -0.102694852980348 3.01803029560291e-07 NA NA NA hsa-miR-129-5p CHEK1 0.567133990117154 0.00116152215679873 -0.573955749984577 8.28992689477782e-16 miRanda -0.122309084327909 1.74565500015445e-11 NA NA NA hsa-miR-139-5p CHEK1 0.647754756897662 2.1537830723695e-06 -0.573955749984577 8.28992689477782e-16 miRanda -0.187266116631356 7.28244952419277e-16 NA NA NA hsa-miR-330-5p CHEK1 0.262932095995619 0.0465226565966542 -0.573955749984577 8.28992689477782e-16 miRanda -0.118282510893023 6.77322870635937e-07 NA NA NA hsa-miR-330-5p CHERP 0.262932095995619 0.0465226565966542 -0.0514899046500119 0.272702826722896 miRanda -0.101072278327788 3.51513254342359e-26 NA NA NA hsa-miR-139-5p CHFR 0.647754756897662 2.1537830723695e-06 -0.173806010481703 9.20048373598027e-05 PITA;miRanda -0.11087528842444 4.60477176731654e-21 NA NA NA hsa-miR-139-5p CHPF 0.647754756897662 2.1537830723695e-06 -0.155422875943405 0.0204483012213096 miRNATAP -0.123372180502214 4.38708118811376e-12 NA NA NA hsa-miR-330-5p CHPF 0.262932095995619 0.0465226565966542 -0.155422875943405 0.0204483012213096 miRNATAP -0.100323361117145 2.84416899192656e-08 NA NA NA hsa-miR-485-3p CHST3 0.530677478972608 0.00148549219838864 0.0277229599600375 0.7037843836396 mirMAP -0.117642197088139 1.1474383933289e-13 NA NA NA hsa-miR-330-5p CHTF18 0.262932095995619 0.0465226565966542 -0.288231671102921 0.000883504216207747 miRanda -0.231189122559 5.76736337138922e-17 NA NA NA hsa-miR-129-5p CIITA 0.567133990117154 0.00116152215679873 -0.965696692794841 2.92342209314587e-10 miRanda;mirMAP -0.151086277168612 0.000144641557963246 NA NA NA hsa-miR-139-5p CIITA 0.647754756897662 2.1537830723695e-06 -0.965696692794841 2.92342209314587e-10 miRanda -0.413421322513203 1.26075239916149e-16 NA NA NA hsa-miR-338-3p CIITA 0.399637046793888 0.00344106432206527 -0.965696692794841 2.92342209314587e-10 mirMAP -0.143317660658965 0.00897103806575045 NA NA NA hsa-miR-490-3p CILP 0.834268051506887 5.26203010743174e-06 -0.113116062399578 0.268941727767824 miRanda -0.113027717657804 3.79771598820455e-06 NA NA NA hsa-miR-330-5p CIRBP 0.262932095995619 0.0465226565966542 0.196476231381192 0.00427185487624091 miRanda -0.112895692905544 6.47987814165319e-13 NA NA NA hsa-miR-330-5p CKAP2L 0.262932095995619 0.0465226565966542 -1.55833773251427 7.25216295769612e-20 miRanda -0.147191618226894 0.0125732607522683 NA NA NA hsa-miR-139-5p CKAP4 0.647754756897662 2.1537830723695e-06 -0.225510446487532 9.42198097278851e-06 miRanda -0.121540214537501 2.3766440335165e-23 NA NA NA hsa-miR-139-5p CKS2 0.647754756897662 2.1537830723695e-06 -0.758927396325664 7.36724291510902e-18 miRanda -0.169306220908233 7.27842786539641e-09 NA NA NA hsa-miR-490-3p CLEC18A 0.834268051506887 5.26203010743174e-06 -0.607282707178237 9.58581970878688e-08 miRanda -0.12380805989975 7.507935661603e-06 NA NA NA hsa-miR-490-3p CLEC18B 0.834268051506887 5.26203010743174e-06 -0.844193157400384 5.8021931723768e-09 miRanda -0.128679791833817 0.000275771576472549 NA NA NA hsa-miR-490-3p CLEC18C 0.834268051506887 5.26203010743174e-06 -0.913602252976681 1.3151276557467e-09 miRanda -0.139367102105297 0.000141966277667244 NA NA NA hsa-miR-129-5p CLEC2B 0.567133990117154 0.00116152215679873 -0.454207390117271 5.6815316805095e-06 miRanda -0.15513823352956 1.0206069010184e-09 NA NA NA hsa-miR-129-5p CLEC2D 0.567133990117154 0.00116152215679873 -0.0479177823354391 0.422698748840252 PITA;miRanda -0.119334321313498 3.41368834082452e-18 NA NA NA hsa-miR-490-3p CLEC2D 0.834268051506887 5.26203010743174e-06 -0.0479177823354391 0.422698748840252 PITA -0.11889304786218 2.10417142502022e-20 NA NA NA hsa-miR-139-5p CLEC5A 0.647754756897662 2.1537830723695e-06 -1.17572644015597 2.751755880407e-07 miRanda -0.505800782595032 1.54851131404833e-11 NA NA NA hsa-miR-139-5p CLIC4 0.647754756897662 2.1537830723695e-06 -0.322332981153439 3.5162392712189e-05 miRanda -0.195279084851907 8.85004883547125e-22 NA NA NA hsa-miR-490-3p CLIC4 0.834268051506887 5.26203010743174e-06 -0.322332981153439 3.5162392712189e-05 miRanda -0.113884384941709 4.73118341462304e-14 NA NA NA hsa-miR-129-5p CMKLR1 0.567133990117154 0.00116152215679873 -0.043857037251545 0.645129376324591 miRanda -0.132285470431921 1.97327617863775e-08 NA NA NA hsa-miR-129-5p CMTM3 0.567133990117154 0.00116152215679873 -0.446058376750553 2.1993505442924e-10 miRanda -0.186300470244788 2.95889291886412e-32 NA NA NA hsa-miR-129-5p CMTM6 0.567133990117154 0.00116152215679873 -0.329956372867111 1.37961042412983e-08 miRanda -0.101296883183125 7.05975488886862e-16 NA NA NA hsa-miR-129-5p CNN3 0.567133990117154 0.00116152215679873 -0.293222476713204 0.000503809817746702 MirTarget;PITA;miRanda -0.103642972176424 6.07800200847297e-09 NA NA NA hsa-miR-139-5p CNN3 0.647754756897662 2.1537830723695e-06 -0.293222476713204 0.000503809817746702 miRanda -0.234499495325758 3.36171125979174e-26 NA NA NA hsa-miR-338-5p CNPY1 0.424003687569646 0.00246415720301228 -0.370439413584567 0.00670343564196048 mirMAP -0.105226793469744 0.0150272400940972 NA NA NA hsa-miR-330-5p CNTLN 0.262932095995619 0.0465226565966542 -0.105996946640506 0.056236563777551 miRanda -0.110092160889891 4.0465119974446e-10 NA NA NA hsa-miR-338-3p CNTLN 0.399637046793888 0.00344106432206527 -0.105996946640506 0.056236563777551 miRanda -0.121830173123424 6.20966457525292e-11 NA NA NA hsa-miR-338-3p COL12A1 0.399637046793888 0.00344106432206527 -0.364709844749782 0.00463372769284667 miRanda -0.104855561909203 0.0212207497080119 NA NA NA hsa-miR-129-5p COL14A1 0.567133990117154 0.00116152215679873 -0.792131541926786 5.25794983899986e-07 miRanda -0.200397757420451 6.99713198904235e-07 NA NA NA hsa-miR-138-5p COL14A1 0.61608764992087 1.35200027885651e-05 -0.792131541926786 5.25794983899986e-07 MirTarget -0.327759203128588 1.33004671541109e-11 NA NA NA hsa-miR-129-5p COL1A1 0.567133990117154 0.00116152215679873 -1.23998298011726 1.14065510873326e-09 miRanda -0.377496478237911 2.64782833300606e-13 NA NA NA hsa-miR-330-3p COL1A1 0.427388106938161 0.003004892844142 -1.23998298011726 1.14065510873326e-09 mirMAP -0.294327210693087 1.96552274542298e-06 NA NA NA hsa-miR-338-3p COL1A1 0.399637046793888 0.00344106432206527 -1.23998298011726 1.14065510873326e-09 miRanda;miRNATAP -0.450502875303921 2.83790953897927e-10 NA NA NA hsa-miR-129-5p COL1A2 0.567133990117154 0.00116152215679873 -0.945719713706377 9.33034616922931e-13 miRanda -0.180359652485836 8.27568981417803e-08 NA NA NA hsa-miR-330-5p COL1A2 0.262932095995619 0.0465226565966542 -0.945719713706377 9.33034616922931e-13 miRanda -0.125110383739967 0.00451257429123947 NA NA NA hsa-miR-490-3p COL1A2 0.834268051506887 5.26203010743174e-06 -0.945719713706377 9.33034616922931e-13 miRanda -0.195400455357079 5.48117127882046e-10 NA NA NA hsa-miR-338-3p COL28A1 0.399637046793888 0.00344106432206527 0.2779828681908 0.171422214458031 miRanda -0.178932854428583 0.0123500294759759 NA NA NA hsa-miR-129-5p COL3A1 0.567133990117154 0.00116152215679873 -1.43331954235497 3.86186762290792e-13 miRanda -0.383488213291544 2.46561381295259e-14 NA NA NA hsa-miR-330-5p COL3A1 0.262932095995619 0.0465226565966542 -1.43331954235497 3.86186762290792e-13 miRanda -0.328423670017465 7.18994943888574e-07 NA NA NA hsa-miR-129-5p COL4A1 0.567133990117154 0.00116152215679873 -1.37431841954318 3.47482076751264e-19 miRanda -0.32153127115203 1.89727248428967e-16 NA NA NA hsa-miR-330-5p COL4A1 0.262932095995619 0.0465226565966542 -1.37431841954318 3.47482076751264e-19 miRanda -0.169099479618787 0.00115978611437664 NA NA NA hsa-miR-490-3p COL4A1 0.834268051506887 5.26203010743174e-06 -1.37431841954318 3.47482076751264e-19 miRanda;miRNATAP -0.318273917640076 3.52952597375553e-18 NA NA NA hsa-miR-338-5p COL4A3 0.424003687569646 0.00246415720301228 -0.0260305519356809 0.857200565210652 MirTarget;PITA -0.107683008602555 0.0184291441935418 NA NA NA hsa-miR-490-3p COL4A6 0.834268051506887 5.26203010743174e-06 0.110260766816314 0.516071453837057 miRanda -0.121177662361868 0.00301903189420177 NA NA NA hsa-miR-338-5p COL5A1 0.424003687569646 0.00246415720301228 -1.16305873994419 5.94137616866247e-12 miRNATAP -0.143479722818249 0.00854153976588641 NA NA NA hsa-miR-338-5p COL5A2 0.424003687569646 0.00246415720301228 -0.918256949383969 4.62260414598681e-13 mirMAP -0.145158828250565 0.000318300961151812 NA NA NA hsa-miR-338-5p COL8A1 0.424003687569646 0.00246415720301228 -1.33285119426545 2.90863593263389e-11 mirMAP -0.163549582670472 0.011388038310939 NA NA NA hsa-miR-129-5p CP 0.567133990117154 0.00116152215679873 -0.856669743502148 5.55275234537968e-05 miRanda -0.12387504899798 0.0238633872884129 NA NA NA hsa-miR-139-5p CP 0.647754756897662 2.1537830723695e-06 -0.856669743502148 5.55275234537968e-05 miRanda -0.406797381352319 5.31117211535801e-09 NA NA NA hsa-miR-330-5p CPNE1 0.262932095995619 0.0465226565966542 -0.142229258865822 0.021102975807524 miRanda -0.137351453415536 7.95245318212046e-17 NA NA NA hsa-miR-490-3p CPNE1 0.834268051506887 5.26203010743174e-06 -0.142229258865822 0.021102975807524 miRanda -0.108212569524091 8.35181651047788e-20 NA NA NA hsa-miR-338-3p CPNE3 0.399637046793888 0.00344106432206527 -0.0329767889675052 0.572757563899907 miRanda -0.1236166584724 5.13914349841435e-17 NA NA NA hsa-miR-330-5p CRB1 0.262932095995619 0.0465226565966542 0.107647254402361 0.258342656640042 miRanda -0.167393757437846 9.25405151483424e-09 NA NA NA hsa-miR-485-3p CRB1 0.530677478972608 0.00148549219838864 0.107647254402361 0.258342656640042 mirMAP -0.147525606412645 9.25805270976978e-11 NA NA NA hsa-miR-129-5p CRISPLD1 0.567133990117154 0.00116152215679873 -0.53924772879056 1.6065360345774e-08 miRanda -0.178175310133301 1.40101437402448e-14 NA NA NA hsa-miR-139-5p CRISPLD1 0.647754756897662 2.1537830723695e-06 -0.53924772879056 1.6065360345774e-08 miRanda -0.311018315608657 1.06904701147049e-26 NA NA NA hsa-miR-330-3p CRISPLD1 0.427388106938161 0.003004892844142 -0.53924772879056 1.6065360345774e-08 MirTarget;PITA;miRNATAP -0.119565914632446 1.79025111154041e-05 NA NA NA hsa-miR-338-5p CRISPLD1 0.424003687569646 0.00246415720301228 -0.53924772879056 1.6065360345774e-08 mirMAP -0.12249187829785 2.59851917727046e-05 NA NA NA hsa-miR-425-3p CRISPLD2 0.173302979693283 0.0801548384038341 0.0170119242125124 0.882490369113066 MirTarget -0.158385881677556 0.00171001073316451 NA NA NA hsa-miR-330-3p CRLS1 0.427388106938161 0.003004892844142 -0.000576490479638814 0.991657194324054 MirTarget -0.119201612744604 5.28519009766511e-20 NA NA NA hsa-miR-139-5p CROCC 0.647754756897662 2.1537830723695e-06 -0.0348976826964771 0.646331707784601 miRanda -0.112365630985232 2.1004074784316e-06 NA NA NA hsa-miR-138-5p CSF3R 0.61608764992087 1.35200027885651e-05 -0.17270397871593 0.111444824636719 MirTarget -0.139153549859984 2.30931003852574e-05 NA NA NA hsa-miR-138-5p CSRP2 0.61608764992087 1.35200027885651e-05 -0.25460400155885 0.0381419342799565 MirTarget -0.256099209474651 3.5355836192218e-13 NA NA NA hsa-miR-138-5p CSTA 0.61608764992087 1.35200027885651e-05 -1.16683910109025 4.58965418347075e-09 MirTarget -0.478688090745134 4.36997549781595e-15 NA NA NA hsa-miR-139-5p CTNNA1 0.647754756897662 2.1537830723695e-06 -0.135884648677173 0.017931343112589 miRanda -0.101457938670615 1.44288810027067e-15 NA NA NA hsa-miR-129-5p CTSC 0.567133990117154 0.00116152215679873 -0.510576931847236 2.36248615433554e-07 MirTarget;miRanda;mirMAP -0.17015856769019 2.10296203925003e-12 NA NA NA hsa-miR-139-5p CTSC 0.647754756897662 2.1537830723695e-06 -0.510576931847236 2.36248615433554e-07 miRanda -0.304373574230141 1.75113886015094e-23 NA NA NA hsa-miR-485-3p CTSC 0.530677478972608 0.00148549219838864 -0.510576931847236 2.36248615433554e-07 mirMAP -0.113933686117122 5.05191103189513e-06 NA NA NA hsa-miR-129-5p CTSS 0.567133990117154 0.00116152215679873 -0.367379000718043 0.000535031478954466 miRanda -0.171264337309229 4.14505231296915e-11 NA NA NA hsa-miR-138-1-3p CTSS 0.446369405595197 0.000598407910928167 -0.367379000718043 0.000535031478954466 MirTarget -0.137393062971044 8.3067928173631e-05 NA NA NA hsa-miR-490-3p CTSW 0.834268051506887 5.26203010743174e-06 -0.798783377879624 1.3761729899183e-07 miRanda -0.157847722197262 1.75502642681439e-05 NA NA NA hsa-miR-139-5p CXCL10 0.647754756897662 2.1537830723695e-06 -1.34078055547933 9.05042475145932e-10 miRanda -0.462341128984362 1.61398820577393e-10 NA NA NA hsa-miR-139-5p CXCL11 0.647754756897662 2.1537830723695e-06 -1.09951809552715 5.93869568772513e-09 miRanda -0.238848373958624 0.000154332512847044 NA NA NA hsa-miR-490-3p CXCL16 0.834268051506887 5.26203010743174e-06 -0.164370792644975 0.0349590177879839 miRanda -0.112468677088653 2.10108953139795e-11 NA NA NA hsa-miR-338-3p CXCR2P1 0.399637046793888 0.00344106432206527 -0.377191032096917 0.0439225610810745 miRanda -0.192445135639798 0.00333536367665912 NA NA NA hsa-miR-139-5p CXCR4 0.647754756897662 2.1537830723695e-06 -0.279791233561939 0.0075188340469038 PITA;miRanda -0.278801554721673 1.3135883927634e-17 NA NA NA hsa-miR-129-5p CYBB 0.567133990117154 0.00116152215679873 -0.212392861682709 0.0912935825963323 miRanda -0.126580025143491 4.62596429956303e-05 NA NA NA hsa-miR-490-3p CYBB 0.834268051506887 5.26203010743174e-06 -0.212392861682709 0.0912935825963323 miRanda -0.136512924196008 2.8174502117286e-06 NA NA NA hsa-miR-139-5p CYBRD1 0.647754756897662 2.1537830723695e-06 -0.0433807377800166 0.639990861508578 miRanda -0.13047390704088 4.82536521620759e-06 NA NA NA hsa-miR-139-5p CYFIP1 0.647754756897662 2.1537830723695e-06 -0.161937316902754 0.0303446244413177 miRanda -0.13609176690584 3.65773281096583e-11 NA NA NA hsa-miR-330-5p CYP21A2 0.262932095995619 0.0465226565966542 -0.108864933607661 0.402248847430481 miRanda -0.129475101641246 0.00254140690141826 NA NA NA hsa-miR-338-3p CYP27B1 0.399637046793888 0.00344106432206527 -0.807760991318815 6.00490653784626e-10 MirTarget;miRanda -0.208978105692817 6.77114465993785e-06 NA NA NA hsa-miR-330-5p CYP27C1 0.262932095995619 0.0465226565966542 0.279521217711967 0.0404182039907992 miRanda -0.155118306871761 0.000587714462926395 NA NA NA hsa-miR-338-3p CYP2U1 0.399637046793888 0.00344106432206527 0.0604440678934886 0.299552551359482 MirTarget -0.100703382325944 5.20009194715223e-09 NA NA NA hsa-miR-139-5p CYTH4 0.647754756897662 2.1537830723695e-06 -0.228123787435432 0.0276079805838174 miRanda -0.237978470563156 3.72299846991312e-13 NA NA NA hsa-miR-129-5p CYTIP 0.567133990117154 0.00116152215679873 -0.391784602292978 0.000643815468980906 miRanda -0.125483833555119 1.93750295343858e-05 NA NA NA hsa-miR-129-5p DAB2 0.567133990117154 0.00116152215679873 -0.134743516972454 0.101745647630372 MirTarget;miRanda -0.158573130422734 8.14530696405388e-17 NA NA NA hsa-miR-139-5p DAB2 0.647754756897662 2.1537830723695e-06 -0.134743516972454 0.101745647630372 miRanda -0.245735210265129 2.53226135614985e-24 NA NA NA hsa-miR-330-5p DAB2 0.262932095995619 0.0465226565966542 -0.134743516972454 0.101745647630372 miRanda -0.100014687883312 7.81493678062747e-05 NA NA NA hsa-miR-330-3p DBF4 0.427388106938161 0.003004892844142 -0.431630573018499 4.49252182854069e-11 MirTarget -0.147632454365299 9.83878074315976e-15 NA NA NA hsa-miR-139-5p DCAF12 0.647754756897662 2.1537830723695e-06 -0.0527404424938593 0.332367385305703 miRNATAP -0.120658714326138 5.61122527382072e-19 NA NA NA hsa-miR-338-3p DCAF12 0.399637046793888 0.00344106432206527 -0.0527404424938593 0.332367385305703 MirTarget;miRanda;miRNATAP -0.116537709963792 1.22140144319493e-15 NA NA NA hsa-miR-338-3p DCAF13 0.399637046793888 0.00344106432206527 -0.155502769999154 0.00112002861188461 miRanda -0.111184655028257 3.03082434643296e-17 NA NA NA hsa-miR-139-5p DCAF4L1 0.647754756897662 2.1537830723695e-06 -0.213662925068151 0.00541565745857718 miRanda -0.107228920454678 2.11138656277674e-05 NA NA NA hsa-miR-330-5p DCLK2 0.262932095995619 0.0465226565966542 0.259494908672783 0.000665730048725191 miRanda -0.117787088105675 1.90150827114148e-09 NA NA NA hsa-miR-330-3p DCX 0.427388106938161 0.003004892844142 0.353023955881512 0.02121596285056 PITA;mirMAP;miRNATAP -0.129230454615803 0.0044427470640695 NA NA NA hsa-miR-138-5p DDR1 0.61608764992087 1.35200027885651e-05 0.0224584798898135 0.770021963226609 mirMAP -0.12767403701495 2.60998803600024e-15 NA NA NA hsa-miR-330-5p DDTL 0.262932095995619 0.0465226565966542 -0.0402489466797307 0.55193432039118 miRanda -0.111554373598774 2.76584678876644e-07 NA NA NA hsa-miR-129-5p DDX11 0.567133990117154 0.00116152215679873 -0.310493120033059 0.000838793002332567 miRanda -0.136519344392056 3.10508356553999e-09 NA NA NA hsa-miR-138-5p DDX11 0.61608764992087 1.35200027885651e-05 -0.310493120033059 0.000838793002332567 MirTarget -0.143942876154978 2.80396692326931e-07 NA NA NA hsa-miR-139-5p DDX11 0.647754756897662 2.1537830723695e-06 -0.310493120033059 0.000838793002332567 miRanda -0.14924303474056 5.64124129233457e-07 NA NA NA hsa-miR-330-5p DDX11 0.262932095995619 0.0465226565966542 -0.310493120033059 0.000838793002332567 MirTarget;miRanda -0.21566834956871 3.31926214062418e-13 NA NA NA hsa-miR-330-3p DDX31 0.427388106938161 0.003004892844142 -0.0927251901063011 0.0202338409193927 mirMAP -0.101366202599891 2.53225560370457e-26 NA NA NA hsa-miR-338-3p DENND1B 0.399637046793888 0.00344106432206527 -0.0267689461473797 0.687765599611461 miRanda -0.113132596901999 9.19635987150423e-07 NA NA NA hsa-miR-129-5p DEPDC1 0.567133990117154 0.00116152215679873 -1.45777515754595 6.28740934650995e-20 miRanda -0.111626471242565 0.00856612414501241 NA NA NA hsa-miR-139-5p DEPDC1 0.647754756897662 2.1537830723695e-06 -1.45777515754595 6.28740934650995e-20 miRanda -0.256861636174143 2.25849252752582e-06 NA NA NA hsa-miR-338-3p DEPDC1 0.399637046793888 0.00344106432206527 -1.45777515754595 6.28740934650995e-20 miRanda -0.217911901279799 0.00017928565400388 NA NA NA hsa-miR-330-5p DHODH 0.262932095995619 0.0465226565966542 -0.151010331571567 0.000820870836583953 miRanda -0.102263224267413 2.44678615664984e-14 NA NA NA hsa-miR-139-5p DHRS3 0.647754756897662 2.1537830723695e-06 0.131609131148362 0.195878101167327 miRanda -0.167664641334445 8.20718823626005e-08 NA NA NA hsa-miR-330-3p DIAPH2 0.427388106938161 0.003004892844142 0.0416746311379779 0.568326152460698 PITA -0.12456997991514 4.03018238294445e-09 NA NA NA hsa-miR-338-5p DIAPH3 0.424003687569646 0.00246415720301228 -0.357901332248506 0.000108962723877733 MirTarget -0.108717870894482 0.000212210269527426 NA NA NA hsa-miR-338-3p DLEU1 0.399637046793888 0.00344106432206527 -0.241369817941909 0.000118681684662185 miRanda -0.150363524208739 9.96656878611965e-13 NA NA NA hsa-miR-490-3p DLEU1 0.834268051506887 5.26203010743174e-06 -0.241369817941909 0.000118681684662185 miRanda -0.133610144971039 4.22376056919437e-21 NA NA NA hsa-miR-330-3p DLG5 0.427388106938161 0.003004892844142 0.147360091910408 0.0416147082808224 mirMAP -0.130349330057193 6.66380561199497e-14 NA NA NA hsa-miR-330-5p DLL1 0.262932095995619 0.0465226565966542 0.293706554700196 0.00827704512534861 miRanda -0.251273206845464 2.30096619918946e-13 NA NA NA hsa-miR-129-5p DMRTA2 0.567133990117154 0.00116152215679873 -0.739307047098559 0.00111568527734139 MirTarget;PITA;miRanda;miRNATAP -0.169679597904588 0.00354956238767975 NA NA NA hsa-miR-129-5p DNAJB11 0.567133990117154 0.00116152215679873 -0.254799469326196 1.70297018820057e-07 miRanda -0.101740660252216 8.04636802260439e-26 NA NA NA hsa-miR-129-5p DNASE1L3 0.567133990117154 0.00116152215679873 -0.258460538518341 0.162754783859118 miRanda -0.152189197346259 0.00127527571083654 NA NA NA hsa-miR-330-3p DNMBP 0.427388106938161 0.003004892844142 0.102664262749843 0.106066596267061 mirMAP -0.141603609392273 3.11917511861151e-18 NA NA NA hsa-miR-139-5p DNMT3A 0.647754756897662 2.1537830723695e-06 -0.271329340511704 5.83997401502433e-07 miRanda -0.106033642140673 1.43697400075045e-10 NA NA NA hsa-miR-138-1-3p DNMT3B 0.446369405595197 0.000598407910928167 -0.329990452550479 3.82769193230854e-07 MirTarget -0.109392310213347 7.3281985828359e-07 NA NA NA hsa-miR-338-3p DOCK11 0.399637046793888 0.00344106432206527 -0.343622342572501 1.60024785156059e-06 miRanda -0.135451295979003 1.43911142781014e-08 NA NA NA hsa-miR-129-5p DOK3 0.567133990117154 0.00116152215679873 -0.442449347596281 4.47663476928015e-07 MirTarget;miRanda -0.143766824995524 6.82232973786593e-11 NA NA NA hsa-miR-139-5p DPEP2 0.647754756897662 2.1537830723695e-06 -0.231395561681395 0.00770711830162832 miRanda -0.163734600611266 7.65224631752413e-09 NA NA NA hsa-miR-338-3p DPY19L3 0.399637046793888 0.00344106432206527 -0.0131003431638517 0.885744859649118 miRanda -0.154474404911586 1.95063550120475e-07 NA NA NA hsa-miR-129-5p DPYD 0.567133990117154 0.00116152215679873 -0.608928067560774 2.81275576410807e-08 miRanda -0.145322584689603 2.32783103955705e-07 NA NA NA hsa-miR-330-3p DPYSL3 0.427388106938161 0.003004892844142 0.0976827098968158 0.229803497266026 MirTarget;PITA;miRNATAP -0.12963116451595 1.80879620225254e-13 NA NA NA hsa-miR-338-5p DPYSL3 0.424003687569646 0.00246415720301228 0.0976827098968158 0.229803497266026 PITA -0.100269062548903 7.12659926311019e-08 NA NA NA hsa-miR-139-5p DRAM1 0.647754756897662 2.1537830723695e-06 -0.205708568558181 0.0109236105483682 miRanda -0.130818777620794 5.75580248330362e-07 NA NA NA hsa-miR-338-3p DRAM1 0.399637046793888 0.00344106432206527 -0.205708568558181 0.0109236105483682 miRanda -0.121685549320781 1.37740273464227e-05 NA NA NA hsa-miR-139-5p DRAM2 0.647754756897662 2.1537830723695e-06 -0.138413976383063 0.0118830022615765 miRanda -0.162150134217851 1.58117933605012e-27 NA NA NA hsa-miR-330-5p DRD2 0.262932095995619 0.0465226565966542 -0.133010749468772 0.291654150824646 miRanda;miRNATAP -0.111497312387841 0.00772288549657691 NA NA NA hsa-miR-330-5p DSCC1 0.262932095995619 0.0465226565966542 -0.444380889529006 1.3045838562608e-14 miRanda -0.134329633589299 7.99140630622608e-13 NA NA NA hsa-miR-490-3p DSCC1 0.834268051506887 5.26203010743174e-06 -0.444380889529006 1.3045838562608e-14 miRanda -0.101122283426667 9.48066281126988e-14 NA NA NA hsa-miR-129-5p DSE 0.567133990117154 0.00116152215679873 -0.281173364317572 4.17240284708769e-06 MirTarget;miRanda;miRNATAP -0.108571721210928 3.5226902577293e-14 NA NA NA hsa-miR-338-3p DSE 0.399637046793888 0.00344106432206527 -0.281173364317572 4.17240284708769e-06 miRanda -0.169437145284046 4.10412793667205e-18 NA NA NA hsa-miR-139-5p DSN1 0.647754756897662 2.1537830723695e-06 -0.527916115095235 6.02420284599909e-19 miRanda -0.103775540705931 1.05810347159393e-07 NA NA NA hsa-miR-129-5p DTL 0.567133990117154 0.00116152215679873 -1.27425876803939 3.3303374960886e-18 miRanda;miRNATAP -0.202728597074305 1.29370375491662e-07 NA NA NA hsa-miR-330-3p DTL 0.427388106938161 0.003004892844142 -1.27425876803939 3.3303374960886e-18 MirTarget;miRNATAP -0.228212269537446 5.0037702841041e-07 NA NA NA hsa-miR-139-5p DTX3L 0.647754756897662 2.1537830723695e-06 -0.48885293211571 7.65423567844051e-11 miRanda -0.233545653210058 9.4421557803225e-25 NA NA NA hsa-miR-490-3p DTX3L 0.834268051506887 5.26203010743174e-06 -0.48885293211571 7.65423567844051e-11 miRanda -0.154294791080235 3.23732945089801e-20 NA NA NA hsa-miR-129-5p DUOXA1 0.567133990117154 0.00116152215679873 0.0458892821375187 0.764498408061357 MirTarget -0.115674514676049 0.00309811136012615 NA NA NA hsa-miR-139-5p DUSP18 0.647754756897662 2.1537830723695e-06 -0.0259349795300112 0.670495986761961 miRanda -0.12987961215063 1.04840527633763e-11 NA NA NA hsa-miR-330-5p DVL3 0.262932095995619 0.0465226565966542 -0.00939128799226552 0.857704514389696 miRNATAP -0.110031511252826 2.03459869563188e-27 NA NA NA hsa-miR-138-5p DYNLT1 0.61608764992087 1.35200027885651e-05 -0.209857417082336 0.000632846447156105 MirTarget -0.177014778917648 7.8191623600039e-28 NA NA NA hsa-miR-139-5p DZIP1L 0.647754756897662 2.1537830723695e-06 -0.45217490100751 3.76895924895419e-11 miRanda -0.198593325623272 1.82395050141474e-19 NA NA NA hsa-miR-490-3p DZIP1L 0.834268051506887 5.26203010743174e-06 -0.45217490100751 3.76895924895419e-11 miRanda -0.146618132746555 6.37572485434877e-20 NA NA NA hsa-miR-330-5p E2F2 0.262932095995619 0.0465226565966542 -1.34827244761579 5.91940938359588e-17 MirTarget;miRNATAP -0.346942874107683 1.70115694039137e-10 NA NA NA hsa-miR-338-3p E2F2 0.399637046793888 0.00344106432206527 -1.34827244761579 5.91940938359588e-17 mirMAP -0.33969687934866 4.05953795332898e-09 NA NA NA hsa-miR-490-3p E2F2 0.834268051506887 5.26203010743174e-06 -1.34827244761579 5.91940938359588e-17 mirMAP -0.262096603370546 2.67497437024177e-11 NA NA NA hsa-miR-129-5p E2F7 0.567133990117154 0.00116152215679873 -1.46591745821464 2.03279508197687e-19 PITA;miRanda;miRNATAP -0.203242513630926 2.21977084334448e-06 NA NA NA hsa-miR-139-5p E2F7 0.647754756897662 2.1537830723695e-06 -1.46591745821464 2.03279508197687e-19 miRanda -0.30425337173357 3.42273144513178e-08 NA NA NA hsa-miR-338-3p E2F7 0.399637046793888 0.00344106432206527 -1.46591745821464 2.03279508197687e-19 miRanda -0.211260561496823 0.000367446719554379 NA NA NA hsa-miR-490-3p E2F7 0.834268051506887 5.26203010743174e-06 -1.46591745821464 2.03279508197687e-19 miRanda -0.175138112519536 1.49911130769205e-05 NA NA NA hsa-miR-139-5p E2F8 0.647754756897662 2.1537830723695e-06 -1.23009836320593 3.5873386919239e-14 miRanda -0.415091339704133 9.73459998941742e-15 NA NA NA hsa-miR-338-3p E2F8 0.399637046793888 0.00344106432206527 -1.23009836320593 3.5873386919239e-14 miRanda -0.261173931779768 7.37369109740679e-06 NA NA NA hsa-miR-139-5p EBF1 0.647754756897662 2.1537830723695e-06 0.086390237836115 0.371889638431109 MirTarget;miRanda;miRNATAP -0.137407112741083 8.90157052872641e-06 NA NA NA hsa-miR-330-5p EBF1 0.262932095995619 0.0465226565966542 0.086390237836115 0.371889638431109 MirTarget;miRanda;miRNATAP -0.163631091565222 1.30802155177016e-07 NA NA NA hsa-miR-330-5p EBF4 0.262932095995619 0.0465226565966542 0.178677330968504 0.0193881415817553 miRanda -0.228048211256794 9.04766140301003e-25 NA NA NA hsa-miR-330-5p EBPL 0.262932095995619 0.0465226565966542 0.0538909592929855 0.343832462728205 miRanda -0.117384510233167 6.7959759182574e-12 NA NA NA hsa-miR-139-5p ECE1 0.647754756897662 2.1537830723695e-06 -0.450211149900418 4.13477673318488e-10 miRanda;miRNATAP -0.127456440956017 1.79483130744872e-09 NA NA NA hsa-miR-129-5p EDA2R 0.567133990117154 0.00116152215679873 -0.387771566027084 0.0314385915375661 PITA;miRanda -0.126730139826204 0.00617496580575448 NA NA NA hsa-miR-129-5p EDNRA 0.567133990117154 0.00116152215679873 -0.201947477822572 0.0672964145309269 miRanda;mirMAP -0.158860714242744 4.29181087841611e-09 NA NA NA hsa-miR-490-3p EDNRA 0.834268051506887 5.26203010743174e-06 -0.201947477822572 0.0672964145309269 miRanda -0.196966426966769 4.45121065247703e-15 NA NA NA hsa-miR-139-5p EDNRB 0.647754756897662 2.1537830723695e-06 0.642714528335702 9.85409274997313e-07 miRanda -0.117498872259038 0.00362355874225894 NA NA NA hsa-miR-330-3p EEF1A1 0.427388106938161 0.003004892844142 0.0569237673563965 0.499566298285765 MirTarget -0.127401944592088 8.42199999959116e-16 NA NA NA hsa-miR-338-3p EEF1G 0.399637046793888 0.00344106432206527 0.0117018130238353 0.888080672810526 miRanda -0.115826381478036 1.03605156902148e-07 NA NA NA hsa-miR-139-5p EFEMP1 0.647754756897662 2.1537830723695e-06 0.0375131593113736 0.775194442107598 miRanda -0.30279314160587 7.86436786655809e-14 NA NA NA hsa-miR-338-3p EFEMP1 0.399637046793888 0.00344106432206527 0.0375131593113736 0.775194442107598 miRanda -0.15777295740178 0.000347320704240582 NA NA NA hsa-miR-490-3p EGFR 0.834268051506887 5.26203010743174e-06 -0.375473556369595 0.0155485714375792 miRNATAP -0.120072101708822 0.00092511979931243 NA NA NA hsa-miR-129-5p EHD4 0.567133990117154 0.00116152215679873 -0.478722656720787 2.26616496219645e-10 miRanda;mirMAP -0.133494608036798 4.28439711438999e-13 NA NA NA hsa-miR-490-3p EHD4 0.834268051506887 5.26203010743174e-06 -0.478722656720787 2.26616496219645e-10 miRanda -0.12429979144834 7.44249260440521e-13 NA NA NA hsa-miR-138-5p EIF4EBP1 0.61608764992087 1.35200027885651e-05 -0.345125060464951 2.64227717559213e-05 MirTarget;miRNATAP -0.193406903930313 4.6473196917631e-16 NA NA NA hsa-miR-139-5p ELF1 0.647754756897662 2.1537830723695e-06 -0.075865291624738 0.217376498881656 miRanda -0.112985568077069 1.03731333197511e-10 NA NA NA hsa-miR-139-5p ELF3 0.647754756897662 2.1537830723695e-06 -0.178131344443977 0.0618894498771037 miRanda -0.140047951821383 6.5704057157113e-06 NA NA NA hsa-miR-129-5p EME1 0.567133990117154 0.00116152215679873 -0.838130854450068 8.06985280044263e-17 MirTarget;miRanda;miRNATAP -0.180306373314067 4.57851759484848e-12 NA NA NA hsa-miR-139-5p EME1 0.647754756897662 2.1537830723695e-06 -0.838130854450068 8.06985280044263e-17 MirTarget;miRanda -0.29965502816936 1.23250324808204e-19 NA NA NA hsa-miR-490-3p EME1 0.834268051506887 5.26203010743174e-06 -0.838130854450068 8.06985280044263e-17 miRanda -0.194157822527534 1.45583931583852e-15 NA NA NA hsa-miR-338-3p EML4 0.399637046793888 0.00344106432206527 -0.288332771137819 4.47982597276691e-08 PITA;miRanda -0.11179038378354 8.52877659886353e-13 NA NA NA hsa-miR-129-5p EMP1 0.567133990117154 0.00116152215679873 -0.476798898618866 0.000708910591580556 miRanda -0.133080877047916 0.000136588509022864 NA NA NA hsa-miR-138-1-3p EMP1 0.446369405595197 0.000598407910928167 -0.476798898618866 0.000708910591580556 MirTarget -0.181007297922544 9.24513333785943e-05 NA NA NA hsa-miR-338-3p EMP1 0.399637046793888 0.00344106432206527 -0.476798898618866 0.000708910591580556 miRanda -0.153206470893674 0.00143194416930254 NA NA NA hsa-miR-139-5p EN1 0.647754756897662 2.1537830723695e-06 -2.19568007489067 1.21480190702927e-15 miRanda -0.544466951840566 3.102016468698e-09 NA NA NA hsa-miR-338-3p EN1 0.399637046793888 0.00344106432206527 -2.19568007489067 1.21480190702927e-15 miRanda;miRNATAP -0.280452145734734 0.00472199176629334 NA NA NA hsa-miR-338-5p EN2 0.424003687569646 0.00246415720301228 -0.756737158489537 2.97963157827706e-06 PITA -0.211060063986032 4.07519806288561e-05 NA NA NA hsa-miR-139-5p ENAH 0.647754756897662 2.1537830723695e-06 -0.0352578814685689 0.600979486904261 PITA;miRNATAP -0.109872288564013 1.79474114963335e-11 NA NA NA hsa-miR-330-3p ENAH 0.427388106938161 0.003004892844142 -0.0352578814685689 0.600979486904261 PITA;mirMAP;miRNATAP -0.108588010929346 3.45883485906891e-13 NA NA NA hsa-miR-338-3p ENAH 0.399637046793888 0.00344106432206527 -0.0352578814685689 0.600979486904261 MirTarget -0.105831506827216 1.48566932611362e-09 NA NA NA hsa-miR-138-5p ENG 0.61608764992087 1.35200027885651e-05 -0.512138061598542 1.40697007867412e-11 miRNATAP -0.126835473141255 5.17219068996492e-09 NA NA NA hsa-miR-129-5p ENPEP 0.567133990117154 0.00116152215679873 -0.992786850376477 3.07766320763444e-14 miRanda -0.262070777713998 4.06267773988063e-15 NA NA NA hsa-miR-330-3p ENPEP 0.427388106938161 0.003004892844142 -0.992786850376477 3.07766320763444e-14 mirMAP -0.258900625814785 7.53742189836819e-11 NA NA NA hsa-miR-330-5p EPHB3 0.262932095995619 0.0465226565966542 -0.188459946665946 0.0154449806440299 MirTarget;PITA;miRanda;miRNATAP -0.109195702544381 5.06105625649814e-06 NA NA NA hsa-miR-490-3p EPSTI1 0.834268051506887 5.26203010743174e-06 -0.666089468247797 1.01967253584863e-08 miRanda -0.116075430280934 4.19651423457788e-05 NA NA NA hsa-miR-139-5p ERAP1 0.647754756897662 2.1537830723695e-06 -0.0673540495230291 0.283708504663353 miRanda -0.104482392361272 8.42463539023265e-09 NA NA NA hsa-miR-129-5p ERCC6L 0.567133990117154 0.00116152215679873 -1.09559645805562 5.80780006180325e-21 miRNATAP -0.165798823815881 7.02321380421471e-08 NA NA NA hsa-miR-129-5p ERI1 0.567133990117154 0.00116152215679873 -0.278415260868348 4.73505527570914e-08 miRanda -0.106331724347245 9.74717255833428e-20 NA NA NA hsa-miR-138-5p ERI1 0.61608764992087 1.35200027885651e-05 -0.278415260868348 4.73505527570914e-08 MirTarget -0.138616179634239 6.96424142059147e-23 NA NA NA hsa-miR-129-5p ESCO2 0.567133990117154 0.00116152215679873 -1.34050561956116 1.56643419137989e-18 miRanda -0.187025678643025 3.34703206461199e-06 NA NA NA hsa-miR-330-5p ESCO2 0.262932095995619 0.0465226565966542 -1.34050561956116 1.56643419137989e-18 miRanda -0.159420731300079 0.00238366705555922 NA NA NA hsa-miR-338-3p ESCO2 0.399637046793888 0.00344106432206527 -1.34050561956116 1.56643419137989e-18 miRanda -0.219904105833508 7.32868491961223e-05 NA NA NA hsa-miR-138-1-3p ESPNL 0.446369405595197 0.000598407910928167 -0.656603651689383 1.23477678949206e-05 mirMAP -0.117758382609882 0.0214381519155831 NA NA NA hsa-miR-330-5p ETS1 0.262932095995619 0.0465226565966542 -0.289405818491844 0.00108094176374586 MirTarget;miRanda -0.127388187945365 3.03085919315415e-06 NA NA NA hsa-miR-338-3p ETS1 0.399637046793888 0.00344106432206527 -0.289405818491844 0.00108094176374586 MirTarget;PITA;miRanda;miRNATAP -0.141646578198775 9.45149495322417e-07 NA NA NA hsa-miR-129-5p ETV1 0.567133990117154 0.00116152215679873 0.127406918040421 0.312313464119974 MirTarget;PITA;miRanda;miRNATAP -0.11694460144481 7.17653759657063e-05 NA NA NA hsa-miR-330-3p ETV1 0.427388106938161 0.003004892844142 0.127406918040421 0.312313464119974 PITA;mirMAP -0.198387297426958 8.92865404278795e-09 NA NA NA hsa-miR-485-3p ETV1 0.530677478972608 0.00148549219838864 0.127406918040421 0.312313464119974 PITA;mirMAP -0.1013830860106 0.000735762202085894 NA NA NA hsa-miR-129-5p ETV6 0.567133990117154 0.00116152215679873 -0.334102281558833 8.90233298016077e-10 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.102731642134152 1.41569385176045e-16 NA NA NA hsa-miR-139-5p ETV7 0.647754756897662 2.1537830723695e-06 -0.754067660024403 5.29193036591443e-08 miRanda -0.111541236970571 0.015516782946773 NA NA NA hsa-miR-338-3p EYA3 0.399637046793888 0.00344106432206527 -0.211865565071738 0.00718478091520991 miRNATAP -0.110557953929218 4.97886657075509e-05 NA NA NA hsa-miR-138-5p EZH2 0.61608764992087 1.35200027885651e-05 -0.760319021185372 9.56079034520981e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.237697173917202 2.84752840689504e-13 23343715;27019355;25994569;24406044;27562865 MiR 138 inhibits tumor growth through repression of EZH2 in non small cell lung cancer; Furthermore knockdown of EZH2 phenocopied the tumor suppressive effects of miR-138 in cell models whereas ectopic expression of EZH2 rescued the suppressive effects of miR-138;MiR 138 Acts as a Tumor Suppressor by Targeting EZH2 and Enhances Cisplatin Induced Apoptosis in Osteosarcoma Cells; We also verified that EZH2 is a direct target of miR-138; Furthermore enhancing EZH2 expression reduced the inhibitory effects of miR-138 on osteosarcoma;FOXP4 downregulation-mediated inhibition on cancer cell growth and invasion was independent on overexpressing EZH2 another direct target of miR-138 in NSCLC;MiR 138 induces renal carcinoma cell senescence by targeting EZH2 and is downregulated in human clear cell renal cell carcinoma; Transfection of miR-138 mimic induced SN-12 cell senescence decreased the protein expression of EZH2 and increased the protein expression of P16; Furthermore miR-138 decreased the 3'UTR luciferase activity of EZH2; MiR-138 is a tumor-suppressor miRNA in ccRCC that induces SN-12 cell senescence by downregulating EZH2 expression and upregulating P16 expression;In the present study the influence of miR-26a and miR-138 on EZH2 and cellular function including the impact on the cell cycle regulating network was evaluated in PCa cells; The present findings suggest an anti-proliferative role for miR-26a and miR-138 in PCa by blocking the G1/S-phase transition independent of EZH2 but via a concerted inhibition of crucial cell cycle regulators ;;;; lung squamous cell cancer;sarcoma;lung squamous cell cancer;kidney renal cell cancer;prostate cancer hsa-miR-139-5p EZH2 0.647754756897662 2.1537830723695e-06 -0.760319021185372 9.56079034520981e-13 miRanda -0.284249987877571 1.38122402585899e-16 NA NA NA hsa-miR-129-5p F2R 0.567133990117154 0.00116152215679873 -0.400354991431698 3.54417987717176e-05 MirTarget;miRanda;mirMAP -0.191278042800133 3.69845010505105e-17 NA NA NA hsa-miR-129-5p F2RL2 0.567133990117154 0.00116152215679873 -0.900541973547345 3.66240973795365e-07 MirTarget -0.125936691236522 0.00594237374797054 NA NA NA hsa-miR-129-5p FABP4 0.567133990117154 0.00116152215679873 -0.267269846450669 0.106061542427622 miRanda -0.185191782417739 1.12509591306663e-05 NA NA NA hsa-miR-138-5p FABP4 0.61608764992087 1.35200027885651e-05 -0.267269846450669 0.106061542427622 miRNAWalker2_validate -0.220884030580769 1.54353932929917e-05 NA NA NA hsa-miR-129-5p FADD 0.567133990117154 0.00116152215679873 -0.216653418892293 1.55270131762904e-06 miRanda -0.101992367892993 3.27715082112241e-26 NA NA NA hsa-miR-330-3p FAM110A 0.427388106938161 0.003004892844142 0.0437245989374708 0.606735805101377 MirTarget;miRNATAP -0.137585045839938 4.47428129564061e-08 NA NA NA hsa-miR-330-3p FAM110B 0.427388106938161 0.003004892844142 0.405434941772876 3.33346699932092e-05 miRNATAP -0.131403463399859 1.50028346662804e-06 NA NA NA hsa-miR-490-3p FAM111A 0.834268051506887 5.26203010743174e-06 -0.488007004342031 5.23291679999813e-11 miRanda -0.14177451471001 4.2914554858234e-17 NA NA NA hsa-miR-129-5p FAM111B 0.567133990117154 0.00116152215679873 -1.3937018107509 1.08470964948567e-16 PITA;miRanda;mirMAP -0.270557680110874 6.36747078345594e-10 NA NA NA hsa-miR-338-3p FAM111B 0.399637046793888 0.00344106432206527 -1.3937018107509 1.08470964948567e-16 MirTarget;miRanda -0.273423700045022 6.59328917113957e-06 NA NA NA hsa-miR-129-5p FAM129A 0.567133990117154 0.00116152215679873 -0.872177672156734 4.99241091415543e-14 mirMAP -0.16634152239002 2.71876803830427e-08 NA NA NA hsa-miR-490-3p FAM129B 0.834268051506887 5.26203010743174e-06 -0.2460401360212 0.00049143798786413 miRanda -0.104797109918245 1.15752599503351e-12 NA NA NA hsa-miR-330-5p FAM180A 0.262932095995619 0.0465226565966542 -0.449704996573707 0.00981191661865778 miRanda -0.200263535269594 0.000536688772125857 NA NA NA hsa-miR-129-5p FAM20A 0.567133990117154 0.00116152215679873 -1.06321624806609 7.09635235140475e-14 miRanda -0.140491827682541 0.000157073046776027 NA NA NA hsa-miR-330-3p FAM35A 0.427388106938161 0.003004892844142 0.0802190605402302 0.0771722971274503 miRNATAP -0.102790891585605 1.89864175257341e-20 NA NA NA hsa-miR-129-5p FAM46A 0.567133990117154 0.00116152215679873 -0.49701258081739 3.36766956672443e-08 PITA;miRanda -0.196481778162211 5.84451935820681e-19 NA NA NA hsa-miR-330-3p FAM46A 0.427388106938161 0.003004892844142 -0.49701258081739 3.36766956672443e-08 PITA;mirMAP -0.143967298115423 7.03181939875146e-08 NA NA NA hsa-miR-338-5p FAM46A 0.424003687569646 0.00246415720301228 -0.49701258081739 3.36766956672443e-08 PITA;mirMAP -0.169405538034614 1.08661815636501e-09 NA NA NA hsa-miR-490-3p FAM46A 0.834268051506887 5.26203010743174e-06 -0.49701258081739 3.36766956672443e-08 PITA;miRanda -0.191433179061865 2.40506099374778e-20 NA NA NA hsa-miR-330-3p FAM46C 0.427388106938161 0.003004892844142 -0.369995045467878 0.00482957469782283 mirMAP;miRNATAP -0.15252130255063 0.000113027732608527 NA NA NA hsa-miR-485-3p FAM46C 0.530677478972608 0.00148549219838864 -0.369995045467878 0.00482957469782283 mirMAP -0.201146035227803 2.39635516603269e-09 NA NA NA hsa-miR-330-3p FAM57A 0.427388106938161 0.003004892844142 -0.194972142581212 0.000138997523607983 mirMAP -0.121435419943304 6.2286918695901e-20 NA NA NA hsa-miR-129-5p FAM60A 0.567133990117154 0.00116152215679873 -0.258096935617758 0.00566981205828615 miRanda -0.183782277658251 1.11637628602286e-16 NA NA NA hsa-miR-485-3p FAM60A 0.530677478972608 0.00148549219838864 -0.258096935617758 0.00566981205828615 PITA;miRNATAP -0.224557087319634 4.80405551839421e-24 NA NA NA hsa-miR-330-3p FAM64A 0.427388106938161 0.003004892844142 -1.73564841089701 2.31661972065508e-21 PITA -0.256864736130609 7.32717124032629e-06 NA NA NA hsa-miR-330-5p FAM64A 0.262932095995619 0.0465226565966542 -1.73564841089701 2.31661972065508e-21 miRanda -0.257125300810433 4.47448266050745e-05 NA NA NA hsa-miR-330-5p FAM71F2 0.262932095995619 0.0465226565966542 0.102144195824617 0.264214926839032 miRanda -0.113198136979021 0.000182577402051696 NA NA NA hsa-miR-139-5p FAM83D 0.647754756897662 2.1537830723695e-06 -0.883078215432625 3.80882045810152e-12 miRanda -0.11533601208354 0.00715192328591516 NA NA NA hsa-miR-129-5p FAM95B1 0.567133990117154 0.00116152215679873 -0.52546950871987 8.07633467401553e-05 miRanda -0.123078795490808 8.72185307553071e-05 NA NA NA hsa-miR-139-5p FAM95B1 0.647754756897662 2.1537830723695e-06 -0.52546950871987 8.07633467401553e-05 miRanda -0.211332316036458 1.45328291773743e-07 NA NA NA hsa-miR-129-5p FAM96A 0.567133990117154 0.00116152215679873 -0.184468881857483 4.79522935941729e-05 miRanda -0.101767289061253 1.01193614685254e-29 NA NA NA hsa-miR-139-5p FANCA 0.647754756897662 2.1537830723695e-06 -0.829387700851373 2.85895572774431e-16 miRanda -0.130751123691899 0.000133044250522253 NA NA NA hsa-miR-330-5p FANCA 0.262932095995619 0.0465226565966542 -0.829387700851373 2.85895572774431e-16 miRanda -0.105017911545216 0.0023492019652927 NA NA NA hsa-miR-338-3p FANCC 0.399637046793888 0.00344106432206527 -0.590705632082106 4.40338032375447e-19 miRanda -0.142390628738315 7.99387415943454e-10 NA NA NA hsa-miR-129-5p FANCD2 0.567133990117154 0.00116152215679873 -0.869041361200973 6.9123617655149e-19 miRanda -0.13909945852245 5.32316397783469e-08 NA NA NA hsa-miR-330-5p FANCE 0.262932095995619 0.0465226565966542 -0.199838769967474 9.25175508798336e-05 miRanda;miRNATAP -0.152318137877624 5.91253189101011e-23 NA NA NA hsa-miR-338-3p FANCE 0.399637046793888 0.00344106432206527 -0.199838769967474 9.25175508798336e-05 miRanda -0.101244856598113 1.83645008498186e-09 NA NA NA hsa-miR-129-5p FANCI 0.567133990117154 0.00116152215679873 -0.884380676812365 7.13180289414887e-18 MirTarget;miRanda -0.127620171232464 1.51642097874318e-06 NA NA NA hsa-miR-338-3p FANCI 0.399637046793888 0.00344106432206527 -0.884380676812365 7.13180289414887e-18 miRanda -0.119986052015322 0.00107465121221592 NA NA NA hsa-miR-129-5p FBLIM1 0.567133990117154 0.00116152215679873 -0.752893820982496 1.68722756535208e-13 miRanda -0.156475495622508 2.52293566110356e-09 NA NA NA hsa-miR-338-3p FBLIM1 0.399637046793888 0.00344106432206527 -0.752893820982496 1.68722756535208e-13 miRanda -0.212064275573583 4.25683256041249e-09 NA NA NA hsa-miR-129-5p FBN2 0.567133990117154 0.00116152215679873 -0.103475736280619 0.513367314240331 miRanda -0.155404294832068 0.000106545894732019 NA NA NA hsa-miR-139-5p FBN2 0.647754756897662 2.1537830723695e-06 -0.103475736280619 0.513367314240331 MirTarget;PITA;miRanda;miRNATAP -0.319436033137024 4.05285950307136e-10 NA NA NA hsa-miR-338-5p FBN2 0.424003687569646 0.00246415720301228 -0.103475736280619 0.513367314240331 mirMAP -0.225913907336427 4.65372309399857e-06 NA NA NA hsa-miR-485-3p FBN2 0.530677478972608 0.00148549219838864 -0.103475736280619 0.513367314240331 MirTarget;PITA;miRNATAP -0.199622538127367 8.94404087878847e-07 NA NA NA hsa-miR-139-5p FBP1 0.647754756897662 2.1537830723695e-06 -0.425575487561834 0.000228866737119827 miRanda -0.317743000240674 1.24332031761395e-17 NA NA NA hsa-miR-425-3p FBXL12 0.173302979693283 0.0801548384038341 -0.176354696793457 3.11663068612366e-06 MirTarget -0.100062217464985 1.28927584342606e-12 NA NA NA hsa-miR-338-3p FBXO30 0.399637046793888 0.00344106432206527 -0.00820050268508687 0.887593805370177 miRanda -0.140107786663446 5.82592381957982e-15 NA NA NA hsa-miR-139-5p FBXO32 0.647754756897662 2.1537830723695e-06 -0.235115324436821 0.0207838961762525 miRanda -0.16407214493939 3.79344983314688e-07 NA NA NA hsa-miR-129-5p FBXO43 0.567133990117154 0.00116152215679873 -0.453854643720363 9.62851726324094e-07 miRanda -0.152064725152353 7.3309224861094e-11 NA NA NA hsa-miR-338-3p FBXO43 0.399637046793888 0.00344106432206527 -0.453854643720363 9.62851726324094e-07 miRanda -0.104466776706681 0.00134340746391443 NA NA NA hsa-miR-490-3p FCGR2A 0.834268051506887 5.26203010743174e-06 -0.579139383433259 9.30455654612231e-07 miRanda -0.207327466260515 3.54932531521582e-14 NA NA NA hsa-miR-338-3p FER 0.399637046793888 0.00344106432206527 -0.0603670404485819 0.507699051164947 miRanda -0.102556653312574 0.00130051303414737 NA NA NA hsa-miR-138-5p FERMT2 0.61608764992087 1.35200027885651e-05 -0.00120937969482426 0.984045000610651 MirTarget;miRNATAP -0.103729148712908 3.89151158074309e-13 NA NA NA hsa-miR-330-5p FGF11 0.262932095995619 0.0465226565966542 0.235018569265872 0.00440939153265397 MirTarget;PITA;miRanda;miRNATAP -0.195003196729419 3.80014150378446e-15 NA NA NA hsa-miR-139-5p FGFBP2 0.647754756897662 2.1537830723695e-06 -0.298450881330119 0.0670389544869406 miRanda -0.149293492357249 0.00556318636289167 NA NA NA hsa-miR-330-5p FGFR4 0.262932095995619 0.0465226565966542 0.113755549365814 0.272566172396582 miRanda;miRNATAP -0.162111818201426 2.05395711443048e-06 NA NA NA hsa-miR-139-5p FGL2 0.647754756897662 2.1537830723695e-06 -0.576185157798732 4.16205710502393e-07 miRanda -0.23615191295091 1.73082196016691e-10 NA NA NA hsa-miR-139-5p FILIP1L 0.647754756897662 2.1537830723695e-06 -0.551512220083513 9.55405325087798e-08 miRanda -0.158603116339442 2.08018504139113e-06 NA NA NA hsa-miR-139-5p FKBP14 0.647754756897662 2.1537830723695e-06 -0.247391244150558 0.000293603255925026 MirTarget -0.122018742304753 1.16551144518378e-08 NA NA NA hsa-miR-330-3p FKBP14 0.427388106938161 0.003004892844142 -0.247391244150558 0.000293603255925026 MirTarget -0.10563364218453 7.46429565925642e-08 NA NA NA hsa-miR-139-5p FKBP5 0.647754756897662 2.1537830723695e-06 -0.147514670086093 0.32629355761366 miRanda -0.112250056707776 0.0209834768367275 NA NA NA hsa-miR-330-3p FLVCR2 0.427388106938161 0.003004892844142 0.108519138686137 0.275063037708549 mirMAP -0.177201924350297 1.27931805473497e-09 NA NA NA hsa-miR-490-3p FLVCR2 0.834268051506887 5.26203010743174e-06 0.108519138686137 0.275063037708549 miRanda -0.163575043483604 1.43018716839084e-12 NA NA NA hsa-miR-139-5p FN1 0.647754756897662 2.1537830723695e-06 -0.611643203379501 4.13939447375655e-09 miRanda -0.251483354032568 4.44995418646961e-16 NA NA NA hsa-miR-129-5p FNDC3B 0.567133990117154 0.00116152215679873 -0.47604352819554 7.9996882347451e-13 miRNAWalker2_validate;miRanda;miRNATAP -0.121631981783056 2.54239411194656e-14 NA NA NA hsa-miR-139-5p FNDC3B 0.647754756897662 2.1537830723695e-06 -0.47604352819554 7.9996882347451e-13 miRanda -0.224449158448324 1.9589943696646e-29 NA NA NA hsa-miR-338-5p FNDC3B 0.424003687569646 0.00246415720301228 -0.47604352819554 7.9996882347451e-13 miRNATAP -0.128121825438369 1.06907579817654e-10 NA NA NA hsa-miR-490-3p FNDC3B 0.834268051506887 5.26203010743174e-06 -0.47604352819554 7.9996882347451e-13 miRanda -0.120198517547109 9.64816010846187e-16 NA NA NA hsa-miR-139-5p FOS 0.647754756897662 2.1537830723695e-06 -0.540206154761066 0.00036747265186214 miRNAWalker2_validate;miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.16678562795059 0.000514206834610942 23001723 Derepression of c Fos caused by microRNA 139 down regulation contributes to the metastasis of human hepatocellular carcinoma; This study investigates whether the anti-metastasis effect of microRNA-139 miR-139 on hepatocellular carcinoma HCC is mediated through regulating c-fos expression; The expression levels of miR-139 and c-fos in human HCC cell sublines with high MHCC97H and low MHCC97L spontaneous metastatic potentials were quantified using QPCR or Western blot; The effect of overexpression or down-expression of miR-139 on c-fos expression of MHCC97H and MHCC97L cells was evaluated using QPCR and Western blot; The 3' untranslated region segments of FOS containing the miR-139 binding sites were amplified by PCR and the luciferase activity in the transfected cells was assayed; In comparison with the expression level of miR-139 in MHCC97L cells the expression level in MHCC97H cells was significantly decreased whereas c-Fos was significantly up-regulated in MHCC97H; The overexpression of miR-139 significantly inhibited the expression of c-fos in MHCC97H cells and the down-expression of miR-139 significantly promoted the expression of c-fos in MHCC97L cells; In vitro cell migration analysis demonstrated that depletion of c-fos or overexpression of miR-139 in MHCC97H cells reduced cell migration whereas overexpression of c-fos or depletion of miR-139 in MHCC97L cells increased cell migration; Derepression of c-Fos caused by miR-139 down-regulation contributes to the metastasis of HCC metastasis;cell migration liver cancer hsa-miR-138-5p FOSL1 0.61608764992087 1.35200027885651e-05 -1.03487462222003 4.87762882989885e-12 miRTarBase -0.284692328939477 1.19315764301941e-09 NA NA NA hsa-miR-129-5p FOXD1 0.567133990117154 0.00116152215679873 -0.787233065417788 3.75901799699905e-08 miRanda -0.208266524413824 1.14101882674954e-08 NA NA NA hsa-miR-338-5p FOXD1 0.424003687569646 0.00246415720301228 -0.787233065417788 3.75901799699905e-08 miRNATAP -0.267032940444997 2.83343853854633e-09 NA NA NA hsa-miR-129-5p FOXD3 0.567133990117154 0.00116152215679873 -0.989893685010833 4.48740399498305e-05 miRanda -0.286058792727094 4.29099746695126e-06 NA NA NA hsa-miR-139-5p FOXL2 0.647754756897662 2.1537830723695e-06 -0.42542785274432 2.81706200729651e-07 miRanda -0.106490346308815 0.000110024146157768 NA NA NA hsa-miR-330-5p FPGS 0.262932095995619 0.0465226565966542 -0.0836067009509227 0.0840759834051622 mirMAP -0.104574354297182 5.19800837766573e-17 NA NA NA hsa-miR-139-5p FPGT 0.647754756897662 2.1537830723695e-06 -0.206848546602792 0.00112884322537563 miRanda -0.126889242228956 1.74390193100929e-10 NA NA NA hsa-miR-139-5p FPR2 0.647754756897662 2.1537830723695e-06 -0.507624468403934 0.00180204432649995 miRanda -0.226508228935904 2.22165817076333e-05 NA NA NA hsa-miR-139-5p FPR3 0.647754756897662 2.1537830723695e-06 -0.821264165232248 3.02490502271986e-06 miRanda -0.662517912472443 1.39295701977106e-33 NA NA NA hsa-miR-129-5p FREM2 0.567133990117154 0.00116152215679873 -0.907442384449335 9.58876510601062e-08 mirMAP -0.130110975742373 0.00300551644339231 NA NA NA hsa-miR-490-3p FREM2 0.834268051506887 5.26203010743174e-06 -0.907442384449335 9.58876510601062e-08 miRanda -0.116218510732859 0.00484537162066595 NA NA NA hsa-miR-139-5p FRMD3 0.647754756897662 2.1537830723695e-06 -0.336677540509305 0.00044638260070663 mirMAP -0.116506747464659 0.000217911999969795 NA NA NA hsa-miR-338-3p FRMD3 0.399637046793888 0.00344106432206527 -0.336677540509305 0.00044638260070663 MirTarget;PITA;miRanda -0.153050851383411 4.88830367922713e-06 NA NA NA hsa-miR-129-5p FST 0.567133990117154 0.00116152215679873 -0.579577075601671 2.41479529598687e-05 MirTarget;miRanda -0.102414102322565 0.00379162276851883 NA NA NA hsa-miR-338-5p FST 0.424003687569646 0.00246415720301228 -0.579577075601671 2.41479529598687e-05 MirTarget -0.146793919968089 0.000755330002276885 NA NA NA hsa-miR-139-5p FSTL1 0.647754756897662 2.1537830723695e-06 -0.710606398240069 7.27048278975403e-13 miRanda -0.264440112150552 1.30044383400336e-17 NA NA NA hsa-miR-330-5p FTSJ3 0.262932095995619 0.0465226565966542 -0.0804764620332801 0.110191272842369 miRNAWalker2_validate -0.118851285914413 4.36179929508355e-27 NA NA NA hsa-miR-139-5p FUCA2 0.647754756897662 2.1537830723695e-06 -0.27145861318317 0.00294284573547157 miRanda -0.172143824078223 3.84550627565098e-09 NA NA NA hsa-miR-330-5p FUT3 0.262932095995619 0.0465226565966542 0.338384119747356 0.0340675031787694 miRanda -0.389245476601191 6.84253218801265e-14 NA NA NA hsa-miR-330-5p FUT5 0.262932095995619 0.0465226565966542 0.186489481297151 0.177481441204116 miRanda -0.224900745760865 9.2098101198362e-07 NA NA NA hsa-miR-139-5p FYB 0.647754756897662 2.1537830723695e-06 -0.338899876096236 0.00236277100005929 miRanda -0.256537465158905 4.77872646459588e-13 NA NA NA hsa-miR-338-3p FZD7 0.399637046793888 0.00344106432206527 0.143353841507984 0.287910445488862 miRanda -0.137166244355571 0.00323076033200257 NA NA NA hsa-miR-338-3p GABPB1 0.399637046793888 0.00344106432206527 -0.182964356029029 5.68141092426492e-06 miRanda;miRNATAP -0.10963831002921 6.55752321337089e-21 NA NA NA hsa-miR-129-5p GADD45A 0.567133990117154 0.00116152215679873 -0.578892696032542 1.73109905217909e-08 miRanda -0.117655587237976 4.85565235622386e-06 NA NA NA hsa-miR-490-3p GAL3ST4 0.834268051506887 5.26203010743174e-06 -0.326550521787058 2.77053874882995e-05 miRanda -0.137461922950109 1.9688695885515e-15 NA NA NA hsa-miR-138-5p GALNT10 0.61608764992087 1.35200027885651e-05 -0.13446752263483 0.08490334459581 MirTarget -0.11804398114353 5.01080796911833e-08 NA NA NA hsa-miR-139-5p GALNT10 0.647754756897662 2.1537830723695e-06 -0.13446752263483 0.08490334459581 miRanda -0.130939155957732 1.25984240196278e-08 NA NA NA hsa-miR-139-5p GALNT2 0.647754756897662 2.1537830723695e-06 -0.238193929879333 3.70498230249168e-05 mirMAP -0.125900423197842 2.83500631490935e-18 NA NA NA hsa-miR-139-5p GALNT3 0.647754756897662 2.1537830723695e-06 -0.649318733722754 4.56097790742964e-06 MirTarget;PITA;miRanda;miRNATAP -0.166329423139975 0.000400700904936443 NA NA NA hsa-miR-129-5p GALNT5 0.567133990117154 0.00116152215679873 -1.31913390517806 1.02036051404051e-09 miRanda -0.170855808256278 0.00209941866856184 NA NA NA hsa-miR-338-3p GALNT5 0.399637046793888 0.00344106432206527 -1.31913390517806 1.02036051404051e-09 miRanda -0.159186584091049 0.0375351583551994 NA NA NA hsa-miR-139-5p GAPT 0.647754756897662 2.1537830723695e-06 -0.590176419217598 0.000236476987429025 miRanda -0.441701379339045 1.23599238947837e-17 NA NA NA hsa-miR-129-5p GAS1 0.567133990117154 0.00116152215679873 -0.711486782928396 6.58051594578094e-14 miRanda -0.112271904702611 3.14769094860931e-06 NA NA NA hsa-miR-330-3p GATA2 0.427388106938161 0.003004892844142 0.078352136779388 0.426039097910438 mirMAP -0.119232391951672 3.91358707136748e-05 NA NA NA hsa-miR-139-5p GATA3 0.647754756897662 2.1537830723695e-06 -1.01145183701658 8.08800662067518e-10 miRanda -0.381616954752697 1.21363758224435e-12 NA NA NA hsa-miR-330-3p GATA3 0.427388106938161 0.003004892844142 -1.01145183701658 8.08800662067518e-10 MirTarget;PITA;miRNATAP -0.131774215952009 0.00874376279253692 NA NA NA hsa-miR-338-3p GATA3 0.399637046793888 0.00344106432206527 -1.01145183701658 8.08800662067518e-10 miRanda -0.25381089045502 1.27352615508175e-05 NA NA NA hsa-miR-338-5p GATA3 0.424003687569646 0.00246415720301228 -1.01145183701658 8.08800662067518e-10 MirTarget;PITA;miRNATAP -0.236370207637005 5.83616212257804e-06 NA NA NA hsa-miR-485-3p GATA3 0.530677478972608 0.00148549219838864 -1.01145183701658 8.08800662067518e-10 PITA -0.134727403417591 0.00183454687860045 NA NA NA hsa-miR-338-3p GATA6 0.399637046793888 0.00344106432206527 -0.692397066651972 7.14775947725082e-05 miRanda -0.200718110598879 0.00110588580313698 NA NA NA hsa-miR-338-5p GATA6 0.424003687569646 0.00246415720301228 -0.692397066651972 7.14775947725082e-05 mirMAP -0.193354517865948 0.000458076382898067 NA NA NA hsa-miR-139-5p GBE1 0.647754756897662 2.1537830723695e-06 -0.212823662827616 0.000566935224872059 miRanda -0.159399406344397 1.29294161061056e-19 NA NA NA hsa-miR-338-3p GBP2 0.399637046793888 0.00344106432206527 -0.821787822620347 5.58458918623364e-08 miRanda -0.288344926397269 4.14730294120786e-08 NA NA NA hsa-miR-139-5p GBP4 0.647754756897662 2.1537830723695e-06 -0.319165854120078 0.000852746844669475 miRanda -0.10419673465846 0.000790331806824047 NA NA NA hsa-miR-139-5p GBP5 0.647754756897662 2.1537830723695e-06 -1.13069686415234 9.39252814828304e-12 miRanda -0.499225311325581 2.01677660240041e-20 NA NA NA hsa-miR-338-3p GBP5 0.399637046793888 0.00344106432206527 -1.13069686415234 9.39252814828304e-12 miRanda -0.301532350872234 3.39979575133804e-07 NA NA NA hsa-miR-338-3p GBP6 0.399637046793888 0.00344106432206527 -0.805273954874753 8.45845322444178e-08 miRanda -0.251479117821995 1.80739784873147e-06 NA NA NA hsa-miR-338-5p GCNT2 0.424003687569646 0.00246415720301228 -0.223535861255225 0.0282426783494706 MirTarget;PITA;miRNATAP -0.118261424163572 0.000221044007705773 NA NA NA hsa-miR-139-5p GCOM1 0.647754756897662 2.1537830723695e-06 -0.693590553140999 4.78846381131145e-06 miRanda -0.193112196043063 0.000125141533082312 NA NA NA hsa-miR-338-3p GCOM1 0.399637046793888 0.00344106432206527 -0.693590553140999 4.78846381131145e-06 miRanda -0.145837696426181 0.00679974966992389 NA NA NA hsa-miR-129-5p GEM 0.567133990117154 0.00116152215679873 -0.590185332987843 4.83011240208893e-06 miRanda -0.127025858756614 9.29239246668325e-05 NA NA NA hsa-miR-129-5p GEN1 0.567133990117154 0.00116152215679873 -0.371648001539565 3.74773218184042e-07 miRanda;mirMAP -0.100912324059045 5.48366437237383e-08 NA NA NA hsa-miR-139-5p GIMAP4 0.647754756897662 2.1537830723695e-06 -0.268154070608594 0.00127993310269855 miRanda -0.161098693920956 7.64464943373557e-10 NA NA NA hsa-miR-139-5p GINS1 0.647754756897662 2.1537830723695e-06 -0.662524913202617 2.57941170151385e-15 miRanda -0.162262110502208 4.00101014399755e-09 NA NA NA hsa-miR-330-3p GINS1 0.427388106938161 0.003004892844142 -0.662524913202617 2.57941170151385e-15 mirMAP -0.12519069376758 8.24491816395689e-07 NA NA NA hsa-miR-338-3p GINS2 0.399637046793888 0.00344106432206527 -0.747623926467209 1.53132141313727e-14 mirMAP -0.126623938210076 0.00028237757921776 NA NA NA hsa-miR-129-5p GINS3 0.567133990117154 0.00116152215679873 0.0179776579064717 0.815081767803762 MirTarget;miRanda -0.111866313065091 2.8828176609337e-09 NA NA NA hsa-miR-129-5p GINS4 0.567133990117154 0.00116152215679873 -0.648733691599466 6.47799752150378e-18 miRanda -0.117155006461751 2.10237630408368e-09 NA NA NA hsa-miR-139-5p GJA1 0.647754756897662 2.1537830723695e-06 0.387095205558568 0.00724305167635585 miRanda -0.107237978918326 0.0174982620508508 NA NA NA hsa-miR-138-1-3p GJC1 0.446369405595197 0.000598407910928167 -0.894587661641881 2.38194057055329e-20 mirMAP -0.147056530946718 1.07979980856768e-05 NA NA NA hsa-miR-330-5p GLCCI1 0.262932095995619 0.0465226565966542 0.0823006336730359 0.352914294038379 miRanda -0.156221517430494 7.44120383824145e-09 NA NA NA hsa-miR-330-5p GLDC 0.262932095995619 0.0465226565966542 0.0102806018417283 0.896236112749364 miRanda -0.134802327568025 2.03050466060203e-08 NA NA NA hsa-miR-139-5p GLI2 0.647754756897662 2.1537830723695e-06 -0.0288200262927294 0.764431434299484 miRanda -0.218762212066306 8.85944782439356e-13 NA NA NA hsa-miR-330-5p GLI2 0.262932095995619 0.0465226565966542 -0.0288200262927294 0.764431434299484 MirTarget -0.107935534723854 0.000581363758168482 NA NA NA hsa-miR-490-3p GLIPR2 0.834268051506887 5.26203010743174e-06 -0.205770617062394 0.00597829168522437 miRanda -0.162424264060715 1.02080616565255e-24 NA NA NA hsa-miR-330-5p GLIS2 0.262932095995619 0.0465226565966542 0.0222500914291031 0.736555184537767 PITA;mirMAP;miRNATAP -0.181813581040432 1.84695823710178e-23 NA NA NA hsa-miR-490-3p GLIS2 0.834268051506887 5.26203010743174e-06 0.0222500914291031 0.736555184537767 miRanda;mirMAP -0.103227599351269 1.76731417768999e-14 NA NA NA hsa-miR-129-5p GLIS3 0.567133990117154 0.00116152215679873 -0.220082139874838 0.0658135952886466 miRanda;mirMAP -0.111538556795386 0.000197355716802371 NA NA NA hsa-miR-338-3p GLIS3 0.399637046793888 0.00344106432206527 -0.220082139874838 0.0658135952886466 mirMAP -0.179240220273674 1.28384325224931e-05 NA NA NA hsa-miR-129-5p GMFG 0.567133990117154 0.00116152215679873 -0.351125632174476 1.8701440947987e-05 miRanda -0.108668828869964 1.21105962683403e-07 NA NA NA hsa-miR-139-5p GNA13 0.647754756897662 2.1537830723695e-06 -0.0155836168018979 0.78966803412229 MirTarget;miRanda -0.125733602631698 7.46622436632872e-21 NA NA NA hsa-miR-129-5p GNAI3 0.567133990117154 0.00116152215679873 -0.19771874826171 0.00127009359424078 miRanda -0.108094712320024 1.66081108763784e-18 NA NA NA hsa-miR-139-5p GNAI3 0.647754756897662 2.1537830723695e-06 -0.19771874826171 0.00127009359424078 PITA;miRanda -0.198354777109869 6.7524801358235e-39 NA NA NA hsa-miR-338-3p GNAI3 0.399637046793888 0.00344106432206527 -0.19771874826171 0.00127009359424078 miRanda -0.138731913188501 3.44270673768228e-16 NA NA NA hsa-miR-490-3p GNAI3 0.834268051506887 5.26203010743174e-06 -0.19771874826171 0.00127009359424078 PITA;miRanda -0.101828090611524 1.43693112387306e-18 NA NA NA hsa-miR-330-5p GNB3 0.262932095995619 0.0465226565966542 0.200475968444112 0.098003756922104 miRanda -0.291053632628046 1.06919259567426e-13 NA NA NA hsa-miR-338-3p GNG12 0.399637046793888 0.00344106432206527 -0.604079373560721 2.54919131069446e-06 miRanda -0.105436010061686 0.0191662071144764 NA NA NA hsa-miR-139-5p GOLGA6L9 0.647754756897662 2.1537830723695e-06 0.243890856688482 0.00239313940019269 miRanda -0.129017663888472 6.95654972503775e-07 NA NA NA hsa-miR-330-3p GOLGA6L9 0.427388106938161 0.003004892844142 0.243890856688482 0.00239313940019269 mirMAP -0.176278575909845 5.9073330269554e-14 NA NA NA hsa-miR-330-5p GOLM1 0.262932095995619 0.0465226565966542 0.134169670389069 0.0454026128974954 miRanda -0.108219361605878 5.14289837075375e-13 NA NA NA hsa-miR-129-5p GPNMB 0.567133990117154 0.00116152215679873 -0.609702536593621 0.000278771744194825 miRanda -0.227052536291276 1.09592569084775e-07 NA NA NA hsa-miR-490-3p GPNMB 0.834268051506887 5.26203010743174e-06 -0.609702536593621 0.000278771744194825 miRanda -0.183819449442507 5.23162301304497e-06 NA NA NA hsa-miR-139-5p GPR183 0.647754756897662 2.1537830723695e-06 -0.379588209629583 0.00361216884850638 miRanda -0.238823683836382 1.80214661868511e-08 NA NA NA hsa-miR-330-5p GPR35 0.262932095995619 0.0465226565966542 -0.179933469667164 0.00672196102412461 miRanda -0.101689747712466 3.3937603725671e-06 NA NA NA hsa-miR-129-5p GPR82 0.567133990117154 0.00116152215679873 -1.43119386426622 1.73979592522839e-13 miRanda;mirMAP -0.360027735963912 5.36100132731081e-13 NA NA NA hsa-miR-129-5p GPRC5A 0.567133990117154 0.00116152215679873 -1.1576396762542 1.55183362419342e-10 miRanda -0.14657278144811 0.0018736868235514 NA NA NA hsa-miR-330-3p GPRC5A 0.427388106938161 0.003004892844142 -1.1576396762542 1.55183362419342e-10 mirMAP -0.127909791153795 0.0218570976433631 NA NA NA hsa-miR-330-5p GPSM1 0.262932095995619 0.0465226565966542 0.175960448207294 0.00968329217996769 mirMAP -0.136707390313051 3.82935800410055e-13 NA NA NA hsa-miR-338-3p GPX3 0.399637046793888 0.00344106432206527 0.384552453233291 0.0240312456372034 miRanda -0.117718819826971 0.0425781488760959 NA NA NA hsa-miR-129-5p GPX7 0.567133990117154 0.00116152215679873 -0.518260044856494 2.48234138525024e-12 miRanda -0.108340433512474 5.77907223858369e-09 NA NA NA hsa-miR-129-5p GPX8 0.567133990117154 0.00116152215679873 -1.16136227935242 2.46572167627415e-14 miRanda -0.18208749992565 4.81495521283527e-06 NA NA NA hsa-miR-129-5p GRHL3 0.567133990117154 0.00116152215679873 0.60796551440863 0.000111675789062239 miRanda -0.169394187451069 2.35769775461529e-05 NA NA NA hsa-miR-139-5p GRHL3 0.647754756897662 2.1537830723695e-06 0.60796551440863 0.000111675789062239 miRanda -0.212318058620573 3.95096237108218e-05 NA NA NA hsa-miR-330-5p GRIK3 0.262932095995619 0.0465226565966542 -0.125008811691334 0.214028772960219 mirMAP;miRNATAP -0.15306675029524 4.58967866329609e-07 NA NA NA hsa-miR-490-3p GSDMA 0.834268051506887 5.26203010743174e-06 -0.308488479552032 0.109012010448448 miRanda -0.183053869451068 7.33228205142642e-05 NA NA NA hsa-miR-330-5p GTF2F2 0.262932095995619 0.0465226565966542 0.159902201858035 0.00386789147199257 miRanda -0.140895493167587 1.14405991096471e-21 NA NA NA hsa-miR-139-5p GTSE1 0.647754756897662 2.1537830723695e-06 -1.39568625070208 3.75113613545698e-22 miRanda -0.35004661461097 6.33473575341772e-13 NA NA NA hsa-miR-338-3p GTSE1 0.399637046793888 0.00344106432206527 -1.39568625070208 3.75113613545698e-22 miRanda -0.297095890669549 1.41590043202577e-08 NA NA NA hsa-miR-490-3p GTSE1 0.834268051506887 5.26203010743174e-06 -1.39568625070208 3.75113613545698e-22 miRanda -0.22416672891566 3.4804548185714e-10 NA NA NA hsa-miR-139-5p GYPC 0.647754756897662 2.1537830723695e-06 -0.056655312335756 0.576045345879791 miRanda -0.225269263576281 1.56215148362144e-12 NA NA NA hsa-miR-338-3p GZMK 0.399637046793888 0.00344106432206527 -1.08517561367457 3.82246946067661e-08 miRanda -0.153048869619587 0.0296789695897471 NA NA NA hsa-miR-330-5p H2AFY2 0.262932095995619 0.0465226565966542 0.435652070765869 0.000101167400492336 miRanda -0.13693080257882 0.000138220821179937 NA NA NA hsa-miR-138-5p H3F3B 0.61608764992087 1.35200027885651e-05 0.0117731638707692 0.862274016237514 MirTarget;miRNATAP -0.112519736665135 1.2361351438559e-19 NA NA NA hsa-miR-139-5p H3F3B 0.647754756897662 2.1537830723695e-06 0.0117731638707692 0.862274016237514 miRanda -0.110214955569396 1.07284120558505e-16 NA NA NA hsa-miR-138-5p H6PD 0.61608764992087 1.35200027885651e-05 -0.202434637783599 0.00105942009343447 mirMAP -0.122030444467088 1.11257564146978e-14 NA NA NA hsa-miR-129-5p HAND2 0.567133990117154 0.00116152215679873 -1.67092629115427 1.92670520257768e-09 miRanda -0.252308729563746 0.000482905978823667 NA NA NA hsa-miR-330-5p HAPLN3 0.262932095995619 0.0465226565966542 -0.592706820706668 7.00221778883136e-10 miRNATAP -0.125800940291549 9.50562982671674e-05 NA NA NA hsa-miR-129-5p HAS3 0.567133990117154 0.00116152215679873 -0.247740395336912 0.000303761584361874 mirMAP -0.101539596791769 4.63181948890462e-09 NA NA NA hsa-miR-129-5p HAUS5 0.567133990117154 0.00116152215679873 -0.327180163737629 4.96303173539082e-08 miRanda -0.11482226865186 2.78382824165279e-16 NA NA NA hsa-miR-139-5p HAUS8 0.647754756897662 2.1537830723695e-06 -0.53131676216263 7.2743610994534e-17 miRanda -0.2169044972462 7.86518186101014e-27 NA NA NA hsa-miR-129-5p HAVCR2 0.567133990117154 0.00116152215679873 -0.237533674868501 0.0326586449197647 miRanda -0.111977494921263 5.50158474587539e-05 NA NA NA hsa-miR-139-5p HCG22 0.647754756897662 2.1537830723695e-06 -0.0437999713289972 0.834677421862525 miRanda -0.150812128893755 0.0172237124704634 NA NA NA hsa-miR-490-3p HCG26 0.834268051506887 5.26203010743174e-06 -0.267543375811339 0.0141224754072266 miRanda -0.126433009480391 1.26932369861355e-06 NA NA NA hsa-miR-139-5p HCP5 0.647754756897662 2.1537830723695e-06 -0.622738035879796 5.40324395329626e-09 miRanda -0.245895433653187 1.61434097013005e-14 NA NA NA hsa-miR-490-3p HCP5 0.834268051506887 5.26203010743174e-06 -0.622738035879796 5.40324395329626e-09 miRanda -0.119990916693869 4.32401120432088e-07 NA NA NA hsa-miR-338-3p HELLS 0.399637046793888 0.00344106432206527 -0.820532264454618 2.15827859177244e-12 miRanda -0.205556686033955 8.32417854216551e-07 NA NA NA hsa-miR-338-5p HELLS 0.424003687569646 0.00246415720301228 -0.820532264454618 2.15827859177244e-12 mirMAP -0.197955395694328 1.17745276765365e-07 NA NA NA hsa-miR-139-5p HES4 0.647754756897662 2.1537830723695e-06 0.253954718273943 0.039597209629422 miRanda -0.148202873424778 0.000237549041060425 NA NA NA hsa-miR-330-5p HES6 0.262932095995619 0.0465226565966542 0.234710689769224 0.0401280164818875 miRNATAP -0.268017274447143 3.44828746456482e-15 NA NA NA hsa-miR-139-5p HEXA 0.647754756897662 2.1537830723695e-06 -0.128188197066155 0.00978960949046405 miRanda -0.108098388511312 8.63079099052361e-20 NA NA NA hsa-miR-490-3p HEXB 0.834268051506887 5.26203010743174e-06 -0.367188686617915 1.01747964440923e-09 miRanda -0.101499624229581 2.08145115557507e-15 NA NA NA hsa-miR-139-5p HEY2 0.647754756897662 2.1537830723695e-06 0.228764763014797 0.0131317538444805 miRanda -0.130714078428389 5.98899863805778e-06 NA NA NA hsa-miR-139-5p HHEX 0.647754756897662 2.1537830723695e-06 -0.362262529196912 2.22439288103837e-05 miRanda -0.246472756135761 1.12384646917842e-19 NA NA NA hsa-miR-490-3p HHEX 0.834268051506887 5.26203010743174e-06 -0.362262529196912 2.22439288103837e-05 miRanda -0.111260592351361 4.29638875576422e-08 NA NA NA hsa-miR-330-5p HIC2 0.262932095995619 0.0465226565966542 0.0117763679930811 0.818856126169216 mirMAP -0.119739834368096 2.50066676617156e-15 NA NA NA hsa-miR-138-5p HIF1A 0.61608764992087 1.35200027885651e-05 0.00484625688145268 0.948287190529189 miRNAWalker2_validate;miRTarBase -0.165502020945438 2.83284283527236e-20 21875287 Western blot and reporter assays were used to assess HIF-1a as a direct target of miR-138; The data showed HIF-1a to be one target of miR-138; Futhermore inhibition of the expression of HIF-1a with specific siRNA or miR-138 could increase apoptosis and reduce the migration of 786-O cells; miR-138 could inhibit the expression of HIF-1a and regulate the apoptosis and migration of ccRCC cells kidney renal cell cancer hsa-miR-139-5p HIF1A 0.647754756897662 2.1537830723695e-06 0.00484625688145268 0.948287190529189 miRanda -0.15297457161476 2.12780776743694e-15 NA NA NA hsa-miR-330-3p HIF1A 0.427388106938161 0.003004892844142 0.00484625688145268 0.948287190529189 MirTarget;PITA -0.116720940808285 6.02712620528516e-11 NA NA NA hsa-miR-338-3p HIF1A 0.399637046793888 0.00344106432206527 0.00484625688145268 0.948287190529189 MirTarget;PITA;miRanda -0.168505832987204 2.19429877940535e-16 NA NA NA hsa-miR-338-5p HIF1A 0.424003687569646 0.00246415720301228 0.00484625688145268 0.948287190529189 MirTarget;PITA;miRNATAP -0.11983832401039 1.29865674406497e-10 NA NA NA hsa-miR-490-3p HLA-A 0.834268051506887 5.26203010743174e-06 -0.531065814900277 3.57298611111929e-09 miRanda -0.170008372376467 6.03701910791565e-21 NA NA NA hsa-miR-129-5p HLA-DMB 0.567133990117154 0.00116152215679873 -0.55529114922724 3.42061336322781e-06 miRanda;mirMAP -0.161752379264766 6.71816096900517e-08 NA NA NA hsa-miR-490-3p HLA-DMB 0.834268051506887 5.26203010743174e-06 -0.55529114922724 3.42061336322781e-06 miRanda -0.171952805900002 8.9598497364768e-10 NA NA NA hsa-miR-338-3p HLA-DPB1 0.399637046793888 0.00344106432206527 -0.957644529370606 3.83763534532275e-11 miRanda -0.1510596840668 0.00302103140448345 NA NA NA hsa-miR-129-5p HLA-DQA1 0.567133990117154 0.00116152215679873 -1.2335497725984 3.93339563833933e-10 miRanda -0.208805138258411 4.22414604958999e-05 NA NA NA hsa-miR-338-3p HLA-DQA1 0.399637046793888 0.00344106432206527 -1.2335497725984 3.93339563833933e-10 miRanda -0.280806104423585 6.19628981556393e-05 NA NA NA hsa-miR-129-5p HLA-DQA2 0.567133990117154 0.00116152215679873 -1.29314645728197 5.80538503475515e-09 miRanda -0.186761481427432 0.00120396984341329 NA NA NA hsa-miR-338-3p HLA-DQB1 0.399637046793888 0.00344106432206527 -1.02369692335341 9.64308607527753e-09 miRanda -0.151222848750137 0.0169678688934592 NA NA NA hsa-miR-129-5p HLA-F 0.567133990117154 0.00116152215679873 -0.509839923539965 1.75801031438369e-08 miRanda -0.109945439982624 1.28805056767639e-06 NA NA NA hsa-miR-490-3p HLA-F 0.834268051506887 5.26203010743174e-06 -0.509839923539965 1.75801031438369e-08 miRanda -0.13301950255565 3.47350292827647e-10 NA NA NA hsa-miR-139-5p HM13 0.647754756897662 2.1537830723695e-06 -0.194094435553477 0.000522730163721324 miRanda -0.136436083807541 9.56639934606418e-26 NA NA NA hsa-miR-129-5p HMGA2 0.567133990117154 0.00116152215679873 -1.15500671522211 1.29553089142025e-07 miRanda;mirMAP -0.180121468672167 0.00134622763130282 NA NA NA hsa-miR-490-3p HMGA2 0.834268051506887 5.26203010743174e-06 -1.15500671522211 1.29553089142025e-07 PITA;miRanda;miRNATAP -0.147513073166237 0.00529364801449807 26341146 MicroRNA 490 3p regulates cell proliferation and apoptosis by targeting HMGA2 in osteosarcoma; Furthermore miR-490-3p bound directly to HMGA2 mRNA 3'UTR and mediated a decrease in HMGA2 mRNA and protein expression; Re-expression of HMGA2 reversed the inhibitory effects of miR-490-3p; Further investigations showed an inverse correlation between low miR-490-3p and high HMGA2 expression in osteosarcoma tissues; Taken together our results suggest that miR-490-3p functions as a potential tumor suppressor by down-regulating HMGA2 expression directly and it may represent a potential therapeutic target for patients with osteosarcoma sarcoma hsa-miR-139-5p HMGB2 0.647754756897662 2.1537830723695e-06 -0.482101681595879 1.87250495014923e-11 miRanda -0.164081365047104 9.72723024454687e-15 NA NA NA hsa-miR-330-5p HMGN1 0.262932095995619 0.0465226565966542 -0.0705115388982165 0.217120767401601 miRanda -0.137540528240417 7.79733697877539e-23 NA NA NA hsa-miR-139-5p HMGN2 0.647754756897662 2.1537830723695e-06 -0.201884470506295 0.00250701066329362 miRanda -0.1897451521786 1.04923814605915e-30 NA NA NA hsa-miR-485-3p HMMR 0.530677478972608 0.00148549219838864 -1.20212441572887 8.01244717713411e-19 MirTarget -0.147452162200033 5.35868188165084e-05 NA NA NA hsa-miR-338-3p HMOX1 0.399637046793888 0.00344106432206527 -0.44408891638879 1.64054927696364e-05 miRanda -0.122201331667412 0.000496280242784372 NA NA NA hsa-miR-139-5p HNF4G 0.647754756897662 2.1537830723695e-06 -0.283323065933321 0.00370658247896909 miRanda -0.186059204526812 5.66391736596919e-09 NA NA NA hsa-miR-338-3p HNF4G 0.399637046793888 0.00344106432206527 -0.283323065933321 0.00370658247896909 MirTarget;miRanda -0.14685546365251 1.86934523789435e-05 NA NA NA hsa-miR-330-5p HNRNPA1 0.262932095995619 0.0465226565966542 0.0727131307375366 0.277556798412494 miRanda;miRNATAP -0.147872718229341 4.43428527402299e-22 NA NA NA hsa-miR-139-5p HNRNPAB 0.647754756897662 2.1537830723695e-06 -0.190579917365619 0.000556612440180033 miRanda -0.139926088777705 3.50686738814379e-27 NA NA NA hsa-miR-139-5p HNRNPF 0.647754756897662 2.1537830723695e-06 -0.146887673089928 0.00366194444430515 miRanda;miRNATAP -0.11968390531561 9.90555454904657e-25 NA NA NA hsa-miR-330-5p HNRNPM 0.262932095995619 0.0465226565966542 -0.0393085160522206 0.466146773798166 miRanda -0.103080394744 6.31515848642188e-24 NA NA NA hsa-miR-139-5p HOXA10 0.647754756897662 2.1537830723695e-06 -1.94179425173195 7.10744796398971e-11 miRanda -0.777548312706 1.79825277856054e-15 NA NA NA hsa-miR-338-5p HOXA10 0.424003687569646 0.00246415720301228 -1.94179425173195 7.10744796398971e-11 PITA;miRNATAP -0.396907250120712 3.3119821190711e-05 NA NA NA hsa-miR-129-5p HOXA11 0.567133990117154 0.00116152215679873 -1.35711900299843 1.207307991822e-06 miRanda -0.255203754260907 0.000422994801116124 NA NA NA hsa-miR-139-5p HOXA13 0.647754756897662 2.1537830723695e-06 -0.708782671206193 0.0119539555129046 miRanda -0.514482184281327 2.92828107457278e-08 NA NA NA hsa-miR-330-3p HOXA13 0.427388106938161 0.003004892844142 -0.708782671206193 0.0119539555129046 PITA -0.211851805759974 0.0137902586190499 NA NA NA hsa-miR-330-5p HOXA13 0.262932095995619 0.0465226565966542 -0.708782671206193 0.0119539555129046 miRanda -0.318321041039015 0.000727708168834869 NA NA NA hsa-miR-338-5p HOXA13 0.424003687569646 0.00246415720301228 -0.708782671206193 0.0119539555129046 mirMAP -0.251545592063033 0.0050782837396158 NA NA NA hsa-miR-129-5p HOXA2 0.567133990117154 0.00116152215679873 -1.56569700013095 3.91795226388305e-11 miRanda -0.282279438628042 3.71099308044395e-06 NA NA NA hsa-miR-129-5p HOXA3 0.567133990117154 0.00116152215679873 -1.80375665327692 4.11888502952275e-12 miRanda -0.323386784368723 1.48233740565538e-06 NA NA NA hsa-miR-338-3p HOXA3 0.399637046793888 0.00344106432206527 -1.80375665327692 4.11888502952275e-12 PITA;miRanda;miRNATAP -0.408028810774482 1.02862048080681e-05 NA NA NA hsa-miR-129-5p HOXA4 0.567133990117154 0.00116152215679873 -1.87710708675828 7.58533343854068e-14 miRanda -0.363385463145973 2.1019962009595e-08 NA NA NA hsa-miR-129-5p HOXA5 0.567133990117154 0.00116152215679873 -1.75201274896684 6.3349768466032e-12 miRanda;miRNATAP -0.275464621600159 2.97553128065942e-05 NA NA NA hsa-miR-338-5p HOXA5 0.424003687569646 0.00246415720301228 -1.75201274896684 6.3349768466032e-12 miRNATAP -0.326062361087833 6.23037057003208e-05 NA NA NA hsa-miR-139-5p HOXA7 0.647754756897662 2.1537830723695e-06 -2.14702631175752 2.3529843183209e-12 miRanda -0.767908085789591 2.55042106336933e-14 NA NA NA hsa-miR-338-3p HOXA7 0.399637046793888 0.00344106432206527 -2.14702631175752 2.3529843183209e-12 miRanda -0.456967210469418 3.04122885042568e-05 NA NA NA hsa-miR-139-5p HOXA9 0.647754756897662 2.1537830723695e-06 -1.29468027487606 1.54547808433412e-08 PITA;miRanda;miRNATAP -0.517374059665773 4.94647241650656e-12 NA NA NA hsa-miR-338-5p HOXA9 0.424003687569646 0.00246415720301228 -1.29468027487606 1.54547808433412e-08 PITA;miRNATAP -0.316356870835161 1.34469447998217e-05 NA NA NA hsa-miR-139-5p HOXB2 0.647754756897662 2.1537830723695e-06 -0.986347013175209 1.14384141540676e-07 PITA;miRanda -0.631525756445728 1.31427792022752e-26 NA NA NA hsa-miR-338-5p HOXB2 0.424003687569646 0.00246415720301228 -0.986347013175209 1.14384141540676e-07 miRNATAP -0.348138907957325 3.09276006738918e-09 NA NA NA hsa-miR-139-5p HOXB3 0.647754756897662 2.1537830723695e-06 -1.401294567577 3.40704321274523e-10 miRanda -0.684695681159316 2.19954755156902e-21 NA NA NA hsa-miR-129-5p HOXB7 0.567133990117154 0.00116152215679873 -0.829511837819358 4.00460882990324e-06 miRanda -0.321713580366934 1.68731800737847e-12 NA NA NA hsa-miR-129-5p HOXC10 0.567133990117154 0.00116152215679873 -1.81397458629645 2.10153119854217e-12 PITA;miRanda;miRNATAP -0.200839670484199 0.00277754974858212 NA NA NA hsa-miR-129-5p HOXC13 0.567133990117154 0.00116152215679873 -1.2751982176372 1.20075551707314e-10 PITA;miRanda;miRNATAP -0.13164288832938 0.00972619289277681 NA NA NA hsa-miR-129-5p HOXC4 0.567133990117154 0.00116152215679873 -1.29920608570737 1.44151273226761e-12 PITA;miRanda;miRNATAP -0.204789854770104 1.87525862636562e-05 NA NA NA hsa-miR-338-5p HOXC4 0.424003687569646 0.00246415720301228 -1.29920608570737 1.44151273226761e-12 miRNATAP -0.260569294640238 1.00321048278796e-05 NA NA NA hsa-miR-129-5p HOXC6 0.567133990117154 0.00116152215679873 -1.49356378608735 4.7565764368537e-11 miRanda -0.172634554266935 0.00337176101981783 NA NA NA hsa-miR-338-5p HOXC8 0.424003687569646 0.00246415720301228 -1.26968401504498 1.68700459070429e-09 miRNATAP -0.258561782198269 0.000102432172349635 NA NA NA hsa-miR-129-5p HOXC9 0.567133990117154 0.00116152215679873 -1.42168338525439 5.25168990264321e-11 miRanda -0.19004784950321 0.000691612141158142 NA NA NA hsa-miR-139-5p HOXD10 0.647754756897662 2.1537830723695e-06 -1.80985563806037 1.90833726646423e-12 PITA;miRanda -0.575003062600131 1.12778338780214e-11 NA NA NA hsa-miR-490-3p HOXD11 0.834268051506887 5.26203010743174e-06 -1.72628559431169 4.59593315670547e-13 miRanda -0.304789180383223 1.28155897608847e-07 NA NA NA hsa-miR-490-3p HOXD13 0.834268051506887 5.26203010743174e-06 -1.8936705635109 9.58704886548753e-15 miRanda -0.256661554789609 1.70081719403048e-05 NA NA NA hsa-miR-129-5p HOXD3 0.567133990117154 0.00116152215679873 -1.44237842563407 1.38138951080087e-08 mirMAP -0.184122869915971 0.00522491335381862 NA NA NA hsa-miR-330-3p HOXD8 0.427388106938161 0.003004892844142 -1.3125179755307 2.14492927015196e-06 PITA;miRNATAP -0.387632597143712 4.03963485482894e-06 NA NA NA hsa-miR-330-5p HSD17B1 0.262932095995619 0.0465226565966542 0.104180989999698 0.0621724693050832 miRanda -0.135978736467236 2.45878145813096e-14 NA NA NA hsa-miR-139-5p HVCN1 0.647754756897662 2.1537830723695e-06 0.17496868121288 0.0959996474005178 miRanda -0.101542352212134 0.00316171905257043 NA NA NA hsa-miR-139-5p IBSP 0.647754756897662 2.1537830723695e-06 -0.97275391442974 0.000125179173379272 miRanda -0.270585646179983 0.00120323156824052 NA NA NA hsa-miR-129-5p ICAM1 0.567133990117154 0.00116152215679873 -0.649393023612105 5.54340803961486e-08 miRanda;miRNATAP -0.122824151269865 5.02269967413204e-05 NA NA NA hsa-miR-338-3p ICAM1 0.399637046793888 0.00344106432206527 -0.649393023612105 5.54340803961486e-08 miRanda -0.143872669125535 0.000564717831527153 NA NA NA hsa-miR-490-3p ICAM1 0.834268051506887 5.26203010743174e-06 -0.649393023612105 5.54340803961486e-08 miRanda -0.139995660756383 8.10981676116293e-07 NA NA NA hsa-miR-330-3p ID1 0.427388106938161 0.003004892844142 0.00319348611937986 0.975701410530946 PITA -0.190722540167723 4.50491951982627e-11 NA NA NA hsa-miR-330-5p ID1 0.262932095995619 0.0465226565966542 0.00319348611937986 0.975701410530946 miRNATAP -0.243561021585028 1.16712952310082e-14 NA NA NA hsa-miR-338-5p ID1 0.424003687569646 0.00246415720301228 0.00319348611937986 0.975701410530946 MirTarget;PITA;miRNATAP -0.131652571211416 1.69196880833732e-05 NA NA NA hsa-miR-139-5p ID4 0.647754756897662 2.1537830723695e-06 0.234603553588286 0.0297206691679873 miRanda -0.210077414997778 9.67872470418785e-12 NA NA NA hsa-miR-330-5p ID4 0.262932095995619 0.0465226565966542 0.234603553588286 0.0297206691679873 miRanda -0.218443778496109 1.79264422423468e-12 NA NA NA hsa-miR-338-5p ID4 0.424003687569646 0.00246415720301228 0.234603553588286 0.0297206691679873 MirTarget;PITA -0.104778302201684 0.000479315594816854 NA NA NA hsa-miR-129-5p IDH1 0.567133990117154 0.00116152215679873 -0.216141444909924 0.000633777977382499 miRanda -0.125494153455114 2.54137708167644e-22 NA NA NA hsa-miR-338-3p IDH1 0.399637046793888 0.00344106432206527 -0.216141444909924 0.000633777977382499 miRanda -0.123191660416882 1.15883998831443e-11 NA NA NA hsa-miR-338-3p IDO1 0.399637046793888 0.00344106432206527 -1.38567168711785 1.75315327832858e-10 miRanda -0.392701305836899 2.92397578893822e-07 NA NA NA hsa-miR-129-5p IER5L 0.567133990117154 0.00116152215679873 -0.55489577578711 2.21397067551702e-08 PITA;miRanda;mirMAP;miRNATAP -0.121168527469366 1.53351074406381e-06 NA NA NA hsa-miR-129-5p IFI44L 0.567133990117154 0.00116152215679873 -0.191301090071056 0.172747462980567 MirTarget;miRanda -0.104208986454782 0.00312697865526902 NA NA NA hsa-miR-129-5p IFRD2 0.567133990117154 0.00116152215679873 -0.170291943396994 0.000593014258048575 miRanda -0.107151798524703 3.49125556333405e-24 NA NA NA hsa-miR-129-5p IGF2BP2 0.567133990117154 0.00116152215679873 -1.37559265899 6.18976567698553e-15 miRanda -0.111624181908835 0.0163331620477386 NA NA NA hsa-miR-129-5p IGF2BP3 0.567133990117154 0.00116152215679873 -1.27832888837672 4.35865642629493e-15 miRanda;mirMAP -0.22687384925972 9.53802309916616e-08 NA NA NA hsa-miR-338-3p IGF2BP3 0.399637046793888 0.00344106432206527 -1.27832888837672 4.35865642629493e-15 miRanda -0.17272192091627 0.00341748454554826 NA NA NA hsa-miR-129-5p IGFBP4 0.567133990117154 0.00116152215679873 -0.577813521468203 8.43166787270068e-09 miRanda -0.202978203513892 6.86857376455642e-17 NA NA NA hsa-miR-330-5p IGFBP4 0.262932095995619 0.0465226565966542 -0.577813521468203 8.43166787270068e-09 MirTarget;miRanda -0.15017423877991 3.20171173574415e-06 NA NA NA hsa-miR-139-5p IGFBP5 0.647754756897662 2.1537830723695e-06 -0.417148685058986 0.00045416814271156 MirTarget;PITA;miRanda -0.207053712625484 1.01354748647231e-08 NA NA NA hsa-miR-129-5p IGFBP7 0.567133990117154 0.00116152215679873 -0.322290066578002 0.00027456866729365 miRanda -0.152403038006667 7.44530896629423e-15 NA NA NA hsa-miR-330-5p IGSF5 0.262932095995619 0.0465226565966542 -0.0204151537480151 0.804263337263412 MirTarget;miRanda -0.175337685589248 6.73652351750932e-11 NA NA NA hsa-miR-129-5p IKBIP 0.567133990117154 0.00116152215679873 -0.62239273469615 1.14234772592447e-20 miRanda -0.177168187407918 5.86484783896736e-27 NA NA NA hsa-miR-338-5p IKBIP 0.424003687569646 0.00246415720301228 -0.62239273469615 1.14234772592447e-20 MirTarget -0.15884742376232 2.79145432807724e-14 NA NA NA hsa-miR-490-3p IKBIP 0.834268051506887 5.26203010743174e-06 -0.62239273469615 1.14234772592447e-20 miRanda -0.15636783354394 1.25034252874543e-23 NA NA NA hsa-miR-139-5p IKBKB 0.647754756897662 2.1537830723695e-06 -0.113293458902751 0.0150457519384955 miRanda -0.130032749382716 1.65206176469125e-33 NA NA NA hsa-miR-129-5p IL10RB 0.567133990117154 0.00116152215679873 -0.316836032421477 4.11810249914696e-10 miRanda -0.133256973023588 2.90326338463969e-34 NA NA NA hsa-miR-129-5p IL15 0.567133990117154 0.00116152215679873 -0.548696352183118 3.05512781066925e-05 miRanda -0.11824762489829 0.000455487507844168 NA NA NA hsa-miR-139-5p IL15 0.647754756897662 2.1537830723695e-06 -0.548696352183118 3.05512781066925e-05 miRanda -0.229020067896396 1.10469871548934e-07 NA NA NA hsa-miR-139-5p IL16 0.647754756897662 2.1537830723695e-06 -0.175160083340662 0.0380483341419404 miRanda -0.160237185614174 3.4776727025222e-09 NA NA NA hsa-miR-129-5p IL18 0.567133990117154 0.00116152215679873 -0.355219054614735 0.00211809094082315 miRanda -0.132236043225217 6.62980685027975e-06 NA NA NA hsa-miR-129-5p IL1RAP 0.567133990117154 0.00116152215679873 -0.717312765597343 4.10950689256491e-10 miRanda -0.107803226648902 0.000247483915875916 NA NA NA hsa-miR-139-5p IL1RAP 0.647754756897662 2.1537830723695e-06 -0.717312765597343 4.10950689256491e-10 miRanda -0.149542112615001 7.84715185528142e-05 NA NA NA hsa-miR-129-5p IL1RN 0.567133990117154 0.00116152215679873 -0.74134217527489 1.01095913413688e-05 miRanda -0.138542621179417 0.00141614707009513 NA NA NA hsa-miR-139-5p IL2RB 0.647754756897662 2.1537830723695e-06 -1.00440373639227 5.18213761407774e-11 miRanda -0.351231095583441 3.32986568961996e-12 NA NA NA hsa-miR-490-3p IL32 0.834268051506887 5.26203010743174e-06 -0.466032997626956 7.69980546140433e-05 miRanda -0.139383012367139 7.35429885205597e-07 NA NA NA hsa-miR-139-5p IL6 0.647754756897662 2.1537830723695e-06 -0.860210379772633 5.71029329538115e-06 miRanda -0.193255461876079 0.00224121799463508 NA NA NA hsa-miR-129-5p IL7 0.567133990117154 0.00116152215679873 -0.684293010682002 9.78223559554214e-10 miRanda -0.107243044709145 0.00020186000418907 NA NA NA hsa-miR-338-5p IL7 0.424003687569646 0.00246415720301228 -0.684293010682002 9.78223559554214e-10 mirMAP -0.128084950134086 0.000321798570969427 NA NA NA hsa-miR-138-5p INHBB 0.61608764992087 1.35200027885651e-05 -0.0251327625400433 0.774840472524573 miRNATAP -0.128623508013105 1.16707558738966e-06 NA NA NA hsa-miR-139-5p IQCH 0.647754756897662 2.1537830723695e-06 -0.35828722280315 5.89333433318032e-06 miRanda -0.180920147321111 2.27591777001983e-12 NA NA NA hsa-miR-338-3p IQCH 0.399637046793888 0.00344106432206527 -0.35828722280315 5.89333433318032e-06 miRanda -0.107610301609725 0.000118231644170111 NA NA NA hsa-miR-338-3p IQUB 0.399637046793888 0.00344106432206527 -0.216186737079492 0.0417363755580862 miRanda -0.136760475228843 0.000241994199694815 NA NA NA hsa-miR-129-5p IRF1 0.567133990117154 0.00116152215679873 -0.663988294653474 4.17289927260233e-13 miRanda;mirMAP -0.162463389789517 1.62512727705768e-12 NA NA NA hsa-miR-139-5p IRF1 0.647754756897662 2.1537830723695e-06 -0.663988294653474 4.17289927260233e-13 miRanda -0.279320129442854 7.08917831223524e-22 NA NA NA hsa-miR-330-5p IRF4 0.262932095995619 0.0465226565966542 0.0327055259577906 0.791862349442103 miRanda -0.102769805408998 0.0124687460864046 NA NA NA hsa-miR-338-3p IRS1 0.399637046793888 0.00344106432206527 0.0543333140757341 0.385337823607821 miRanda -0.108489978179845 1.22222189165519e-07 NA NA NA hsa-miR-330-3p IRX2 0.427388106938161 0.003004892844142 0.988864225872126 0.000270413370683676 miRNATAP -0.272041574530052 0.000954016256865845 NA NA NA hsa-miR-338-3p IRX2 0.399637046793888 0.00344106432206527 0.988864225872126 0.000270413370683676 miRanda -0.269074463600908 0.00505070543415544 NA NA NA hsa-miR-129-5p IRX5 0.567133990117154 0.00116152215679873 -1.44406860467649 3.8316294844419e-11 miRanda -0.186817003341396 0.00105568692758998 NA NA NA hsa-miR-338-3p IRX5 0.399637046793888 0.00344106432206527 -1.44406860467649 3.8316294844419e-11 miRanda -0.352784567989665 6.16171222518669e-06 NA NA NA hsa-miR-490-3p IRX5 0.834268051506887 5.26203010743174e-06 -1.44406860467649 3.8316294844419e-11 miRanda -0.230596713279447 1.59507344846437e-05 NA NA NA hsa-miR-129-5p ITGA1 0.567133990117154 0.00116152215679873 -0.647609426727046 7.58957590830568e-11 miRanda -0.105557410819997 3.44533920049207e-05 NA NA NA hsa-miR-139-5p ITGA2 0.647754756897662 2.1537830723695e-06 -0.355153037928831 0.00304131178560754 PITA;miRanda -0.159226995505735 5.04565253757112e-05 NA NA NA hsa-miR-139-5p ITGA3 0.647754756897662 2.1537830723695e-06 -0.364680029117307 0.000107542743333007 PITA;miRanda -0.119533322985041 6.78867558206547e-05 NA NA NA hsa-miR-139-5p ITGA4 0.647754756897662 2.1537830723695e-06 -0.755915416267328 1.40145318456074e-09 miRanda -0.179600818926381 1.59391773868857e-05 NA NA NA hsa-miR-338-3p ITGA5 0.399637046793888 0.00344106432206527 -0.793342094273241 2.60153014640106e-16 miRanda -0.214024001607437 1.88859538954314e-10 NA NA NA hsa-miR-139-5p ITGAL 0.647754756897662 2.1537830723695e-06 -0.490432754210213 0.000120640713451475 miRanda -0.327991075714675 1.80620310884105e-15 NA NA NA hsa-miR-129-5p ITGB1 0.567133990117154 0.00116152215679873 -0.371181257932711 2.75495842292715e-08 miRanda -0.102646377953306 2.01213240209488e-13 NA NA NA hsa-miR-139-5p ITGB1 0.647754756897662 2.1537830723695e-06 -0.371181257932711 2.75495842292715e-08 miRanda -0.157507949857377 8.78792578024261e-19 NA NA NA hsa-miR-139-5p ITGB3 0.647754756897662 2.1537830723695e-06 -0.895350443268113 1.27253189630245e-11 miRanda -0.336235853933377 1.03825075718253e-14 NA NA NA hsa-miR-338-3p ITGB3 0.399637046793888 0.00344106432206527 -0.895350443268113 1.27253189630245e-11 miRanda -0.26366444264679 2.00838730947514e-08 27431198 Furthermore we also identified a metastasis related protein integrin β3 ITGB3 as a novel target gene of miR-338 metastasis lung cancer hsa-miR-139-5p ITGB3BP 0.647754756897662 2.1537830723695e-06 -0.396761604862842 1.17924969699252e-09 miRanda -0.201667634163623 1.08498386258841e-22 NA NA NA hsa-miR-139-5p ITGB5 0.647754756897662 2.1537830723695e-06 0.0173135223800065 0.843025832674024 miRanda -0.145436981829557 6.0927739548774e-08 NA NA NA hsa-miR-139-5p ITGB8 0.647754756897662 2.1537830723695e-06 -0.0287731618011122 0.749085546410232 PITA;miRanda;miRNATAP -0.170381107731951 1.41414791437226e-10 NA NA NA hsa-miR-338-3p ITGB8 0.399637046793888 0.00344106432206527 -0.0287731618011122 0.749085546410232 miRanda -0.119147026110385 3.20449478455922e-05 NA NA NA hsa-miR-139-5p ITPKC 0.647754756897662 2.1537830723695e-06 -0.305484926415358 2.5112447457096e-05 miRanda -0.141735900793825 2.1232466698907e-10 NA NA NA hsa-miR-129-5p ITPRIPL2 0.567133990117154 0.00116152215679873 -0.351857353850217 3.89185549787332e-08 mirMAP -0.113411098864488 3.83579417104615e-14 NA NA NA hsa-miR-129-5p JAG1 0.567133990117154 0.00116152215679873 -0.587520818551872 2.624067182555e-12 PITA;miRanda;miRNATAP -0.146180096254993 2.16509743563399e-13 NA NA NA hsa-miR-485-3p JAG1 0.530677478972608 0.00148549219838864 -0.587520818551872 2.624067182555e-12 MirTarget;PITA;miRNATAP -0.114779137970637 2.10284830535746e-08 NA NA NA hsa-miR-490-3p JAG1 0.834268051506887 5.26203010743174e-06 -0.587520818551872 2.624067182555e-12 miRanda -0.163289933194028 1.20492489703191e-18 NA NA NA hsa-miR-330-3p JAM2 0.427388106938161 0.003004892844142 -0.0952374271716048 0.151461251445391 PITA;miRNATAP -0.105936853037386 5.26320095714087e-10 NA NA NA hsa-miR-139-5p JUN 0.647754756897662 2.1537830723695e-06 -0.379545846500307 7.46220464318713e-05 MirTarget;PITA;miRanda;miRNATAP -0.185022658773887 2.83059205114288e-11 25499265 In this study we report the identification of a novel negative feedback loop formed between miR-139 and its oncogenic target Jun; In this loop miR-139 could inhibit Jun expression by targeting a conserved site on its 3'-UTR whereas Jun could induce miR-139 expression in a dose dependent manner through a distant upstream regulatory element; Interestingly aberration in this loop was found in human gastric cancer where miR-139 was down-regulated and inversely correlated with Jun expression; Further functional analysis showed that restored expression of miR-139 in gastric cancer cells significantly induces apoptosis and inhibits cell migration and proliferation as well as tumour growth through targeting Jun; Given that miR-139 and Jun are deregulated in many cancers our findings here might have broader implication in other types of human cancers cell migration gastric cancer hsa-miR-490-3p KANK2 0.834268051506887 5.26203010743174e-06 -0.450516481403428 1.26947712079305e-07 miRanda -0.123131586277841 8.8184697501447e-11 NA NA NA hsa-miR-139-5p KCNJ8 0.647754756897662 2.1537830723695e-06 0.0860082973051743 0.19662337800354 miRanda -0.110711944497458 1.04458919005522e-07 NA NA NA hsa-miR-338-3p KCNJ8 0.399637046793888 0.00344106432206527 0.0860082973051743 0.19662337800354 miRanda -0.113433824301573 3.32437381706085e-07 NA NA NA hsa-miR-139-5p KCTD12 0.647754756897662 2.1537830723695e-06 0.0796662919961824 0.381927114546542 mirMAP;miRNATAP -0.124141685713116 4.04267069580209e-06 NA NA NA hsa-miR-330-5p KCTD15 0.262932095995619 0.0465226565966542 0.0191650279824209 0.74647964464113 PITA;miRanda -0.117543905679561 4.0376894521484e-14 NA NA NA hsa-miR-330-3p KCTD5 0.427388106938161 0.003004892844142 -0.073359214360722 0.125123632704781 MirTarget -0.101311151751753 1.38734328122738e-25 NA NA NA hsa-miR-330-5p KCTD5 0.262932095995619 0.0465226565966542 -0.073359214360722 0.125123632704781 miRanda -0.10785847458825 5.27900667637576e-24 NA NA NA hsa-miR-139-5p KDELC1 0.647754756897662 2.1537830723695e-06 -0.308052289905702 7.10432003676237e-07 miRanda -0.172281886600882 1.10161942681383e-18 NA NA NA hsa-miR-139-5p KDELC2 0.647754756897662 2.1537830723695e-06 -0.337584778903516 0.000198289209379508 miRanda -0.201320976749176 2.73152604390703e-12 NA NA NA hsa-miR-129-5p KDELR2 0.567133990117154 0.00116152215679873 -0.339684679576526 1.02136680588507e-09 miRanda -0.107433539443085 1.25386522997617e-24 NA NA NA hsa-miR-338-3p KDELR2 0.399637046793888 0.00344106432206527 -0.339684679576526 1.02136680588507e-09 miRanda -0.111279165154306 4.35562251470342e-14 NA NA NA hsa-miR-338-3p KDM5A 0.399637046793888 0.00344106432206527 -0.131384250448589 0.0298876799606062 miRanda -0.108478212485702 9.50584423166188e-10 NA NA NA hsa-miR-338-3p KDM5B 0.399637046793888 0.00344106432206527 0.00258719218091308 0.965934728413275 miRanda -0.107836657053128 6.8137989549429e-11 NA NA NA hsa-miR-129-5p KIAA0040 0.567133990117154 0.00116152215679873 -0.883035450483755 5.4069991199452e-14 miRanda -0.150941937705457 6.66899791994164e-07 NA NA NA hsa-miR-338-3p KIAA0040 0.399637046793888 0.00344106432206527 -0.883035450483755 5.4069991199452e-14 miRanda -0.181350698022711 1.47149680437516e-05 NA NA NA hsa-miR-330-5p KIAA0907 0.262932095995619 0.0465226565966542 -0.0821051554142107 0.0818839401176284 miRanda -0.10131181280555 6.0250852223875e-19 NA NA NA hsa-miR-338-3p KIF11 0.399637046793888 0.00344106432206527 -0.836719965075863 1.27397641827997e-16 miRanda -0.181378985544369 4.42504755630735e-07 NA NA NA hsa-miR-139-5p KIF15 0.647754756897662 2.1537830723695e-06 -0.875897004783482 8.02396770616813e-15 miRanda -0.224975812751317 2.13339298646837e-09 NA NA NA hsa-miR-129-5p KIF18A 0.567133990117154 0.00116152215679873 -1.34602484462402 1.53690470392358e-21 miRanda -0.208864208928246 2.11305678204741e-08 NA NA NA hsa-miR-139-5p KIF18A 0.647754756897662 2.1537830723695e-06 -1.34602484462402 1.53690470392358e-21 miRanda -0.407029020428179 5.3090760281782e-18 NA NA NA hsa-miR-338-5p KIF18A 0.424003687569646 0.00246415720301228 -1.34602484462402 1.53690470392358e-21 MirTarget;miRNATAP -0.251990820412155 4.35117767470488e-08 NA NA NA hsa-miR-129-5p KIF20A 0.567133990117154 0.00116152215679873 -1.84523684675685 1.77370858126816e-22 miRanda -0.290864441514461 6.01039782952487e-09 NA NA NA hsa-miR-330-5p KIF22 0.262932095995619 0.0465226565966542 -0.1366444329947 0.0206275227433478 miRanda -0.107663471452784 2.30186024712879e-10 NA NA NA hsa-miR-129-5p KIF23 0.567133990117154 0.00116152215679873 -1.51377600805087 3.38559172298887e-22 miRanda -0.181619368930517 1.2371131427634e-05 NA NA NA hsa-miR-139-5p KIF23 0.647754756897662 2.1537830723695e-06 -1.51377600805087 3.38559172298887e-22 miRanda -0.310755752048345 5.0658640763015e-09 NA NA NA hsa-miR-330-5p KIF23 0.262932095995619 0.0465226565966542 -1.51377600805087 3.38559172298887e-22 miRanda;miRNATAP -0.1377656422959 0.0110342215447835 NA NA NA hsa-miR-338-3p KIF23 0.399637046793888 0.00344106432206527 -1.51377600805087 3.38559172298887e-22 miRanda -0.263225707104519 3.95327764483949e-06 NA NA NA hsa-miR-490-3p KIF23 0.834268051506887 5.26203010743174e-06 -1.51377600805087 3.38559172298887e-22 miRNATAP -0.169549382688442 1.43493812749147e-05 NA NA NA hsa-miR-330-5p KIF2C 0.262932095995619 0.0465226565966542 -1.45853938930565 7.19293297440399e-23 miRanda -0.212762267542364 3.12379162849936e-05 NA NA NA hsa-miR-490-3p KIF4A 0.834268051506887 5.26203010743174e-06 -1.42480881463336 7.0879727504137e-24 miRNATAP -0.166292391369846 2.63656925216306e-06 NA NA NA hsa-miR-490-3p KIF7 0.834268051506887 5.26203010743174e-06 -0.0116356702077942 0.823691535671482 miRanda -0.113007277427504 2.9677689832989e-28 NA NA NA hsa-miR-338-3p KIRREL 0.399637046793888 0.00344106432206527 -0.465166069462494 0.000126389001260487 mirMAP -0.305618302821144 2.44666954280424e-13 NA NA NA hsa-miR-338-5p KIRREL 0.424003687569646 0.00246415720301228 -0.465166069462494 0.000126389001260487 mirMAP -0.166840055514631 1.17649594530451e-05 NA NA NA hsa-miR-330-5p KLF1 0.262932095995619 0.0465226565966542 0.227936682783783 0.0227125294620413 MirTarget;miRanda;miRNATAP -0.126305445912758 0.000138123964999607 NA NA NA hsa-miR-139-5p KLF6 0.647754756897662 2.1537830723695e-06 -0.274331961724204 0.000239202814552317 miRanda -0.104866538876812 1.56881309112972e-06 NA NA NA hsa-miR-330-5p KLHDC8A 0.262932095995619 0.0465226565966542 -0.654904443005962 3.77849075406215e-08 miRanda -0.114623922145473 0.00373952453326503 NA NA NA hsa-miR-338-3p KLHL13 0.399637046793888 0.00344106432206527 0.063092958634992 0.349893112220956 miRanda -0.132571590788289 1.35683203496166e-09 NA NA NA hsa-miR-330-5p KLHL25 0.262932095995619 0.0465226565966542 0.415763242889651 6.85295415260577e-08 MirTarget -0.15113232857677 2.93542506868923e-11 NA NA NA hsa-miR-490-3p KLHL6 0.834268051506887 5.26203010743174e-06 -0.290523554046229 0.00969863488328336 miRanda -0.13921178439346 1.83028442634385e-07 NA NA NA hsa-miR-129-5p KLRK1 0.567133990117154 0.00116152215679873 0.47811404509181 0.00108567771503282 MirTarget -0.109500569772544 0.00347149521356231 NA NA NA hsa-miR-330-5p KLRK1 0.262932095995619 0.0465226565966542 0.47811404509181 0.00108567771503282 miRanda -0.254739826822851 1.20917614031133e-07 NA NA NA hsa-miR-330-5p KRT10 0.262932095995619 0.0465226565966542 -0.0889295878571783 0.0570468647390607 miRanda -0.109926915984736 1.13514838342724e-16 NA NA NA hsa-miR-138-1-3p KYNU 0.446369405595197 0.000598407910928167 -0.746872147652253 1.08295550996061e-07 MirTarget -0.176110824001162 0.000262263190391703 NA NA NA hsa-miR-129-5p LAIR1 0.567133990117154 0.00116152215679873 -0.413849344583697 0.000309539355099157 miRanda -0.156394756912914 4.7226872459697e-08 NA NA NA hsa-miR-129-5p LAMA4 0.567133990117154 0.00116152215679873 -0.343573577397333 0.000143732452464293 MirTarget;miRanda -0.104576097193653 2.37289060359336e-06 NA NA NA hsa-miR-338-3p LAMA4 0.399637046793888 0.00344106432206527 -0.343573577397333 0.000143732452464293 miRanda -0.219743496703228 2.4511319568882e-13 NA NA NA hsa-miR-129-5p LAMA5 0.567133990117154 0.00116152215679873 -0.0977770802486972 0.191107394925817 miRanda -0.104926803973489 7.21248312811229e-10 NA NA NA hsa-miR-129-5p LAMC1 0.567133990117154 0.00116152215679873 -0.643575172906647 1.88021715964262e-13 miRanda -0.137358273741041 8.7710329568346e-11 NA NA NA hsa-miR-139-5p LAMC1 0.647754756897662 2.1537830723695e-06 -0.643575172906647 1.88021715964262e-13 miRanda -0.267458058003669 6.97400330454346e-24 NA NA NA hsa-miR-338-3p LAMC1 0.399637046793888 0.00344106432206527 -0.643575172906647 1.88021715964262e-13 MirTarget;miRanda -0.235233133578316 2.91064562407468e-16 NA NA NA hsa-miR-338-3p LAPTM4A 0.399637046793888 0.00344106432206527 -0.0945320326508368 0.103558654768688 miRanda -0.102100860055274 6.92789730457257e-14 NA NA NA hsa-miR-129-5p LAPTM5 0.567133990117154 0.00116152215679873 -0.25812825620535 0.0177303823448326 miRanda -0.12817256460282 6.49348358452724e-07 NA NA NA hsa-miR-129-5p LBR 0.567133990117154 0.00116152215679873 -0.221741723474953 5.40025892816413e-05 MirTarget;PITA;miRanda -0.106953887624955 5.36016105982786e-21 NA NA NA hsa-miR-139-5p LCP1 0.647754756897662 2.1537830723695e-06 -0.293646130704476 0.00324233131944012 miRanda -0.24669332658865 1.85476894812371e-15 NA NA NA hsa-miR-338-3p LEFTY2 0.399637046793888 0.00344106432206527 -0.591476641811131 0.0132161419478144 miRanda -0.318098919876763 0.000151592579196879 NA NA NA hsa-miR-139-5p LENG8 0.647754756897662 2.1537830723695e-06 -0.00379120653427023 0.965010240184901 miRanda -0.113830748496378 6.67971180168515e-06 NA NA NA hsa-miR-129-5p LHFPL3 0.567133990117154 0.00116152215679873 0.238582161831187 0.0955944609774394 miRanda -0.155616872283226 8.85396016110306e-06 NA NA NA hsa-miR-490-3p LHFPL3 0.834268051506887 5.26203010743174e-06 0.238582161831187 0.0955944609774394 miRanda -0.111790353582895 0.000722482921380112 NA NA NA hsa-miR-330-5p LHX1 0.262932095995619 0.0465226565966542 -0.154236004947202 0.513111018018009 miRanda -0.287765714355159 0.000243806160606106 NA NA NA hsa-miR-139-5p LHX9 0.647754756897662 2.1537830723695e-06 -0.753093781331949 0.00438758739504132 miRanda -0.329503861262589 0.000163010989820588 NA NA NA hsa-miR-330-3p LHX9 0.427388106938161 0.003004892844142 -0.753093781331949 0.00438758739504132 mirMAP -0.165566085105554 0.0396504687399101 NA NA NA hsa-miR-330-5p LHX9 0.262932095995619 0.0465226565966542 -0.753093781331949 0.00438758739504132 miRanda -0.185293558697534 0.0359648116754315 NA NA NA hsa-miR-338-5p LHX9 0.424003687569646 0.00246415720301228 -0.753093781331949 0.00438758739504132 mirMAP -0.206351720730821 0.0140041401912534 NA NA NA hsa-miR-338-5p LIF 0.424003687569646 0.00246415720301228 -1.17272538294774 4.1576768520385e-12 mirMAP -0.240981711426042 9.17332380712418e-06 NA NA NA hsa-miR-338-3p LILRB2 0.399637046793888 0.00344106432206527 -0.363014633579179 0.00302224591619278 miRanda -0.153737482067187 0.000357871753087376 NA NA NA hsa-miR-129-5p LILRB3 0.567133990117154 0.00116152215679873 -0.603961465369621 2.38982262616656e-05 miRanda -0.237486652066068 5.94935895767911e-11 NA NA NA hsa-miR-129-5p LILRB4 0.567133990117154 0.00116152215679873 -0.18179793362878 0.140255433600247 miRanda -0.148592471258224 1.23886662463567e-06 NA NA NA hsa-miR-129-5p LIMA1 0.567133990117154 0.00116152215679873 -0.133743790062765 0.115901438690002 miRanda -0.151954048968832 4.33841722723731e-16 NA NA NA hsa-miR-338-3p LIMA1 0.399637046793888 0.00344106432206527 -0.133743790062765 0.115901438690002 miRanda -0.133602188590957 3.34626942061463e-07 NA NA NA hsa-miR-129-5p LIMD1 0.567133990117154 0.00116152215679873 -0.437989133660592 7.14324979231238e-07 mirMAP -0.152948024441563 1.06157321640096e-12 NA NA NA hsa-miR-330-3p LIMD1 0.427388106938161 0.003004892844142 -0.437989133660592 7.14324979231238e-07 MirTarget;mirMAP -0.129782180566645 4.2640223716056e-07 NA NA NA hsa-miR-338-5p LIMD1 0.424003687569646 0.00246415720301228 -0.437989133660592 7.14324979231238e-07 mirMAP -0.105065817495146 9.60843139991043e-05 NA NA NA hsa-miR-485-3p LIMD1 0.530677478972608 0.00148549219838864 -0.437989133660592 7.14324979231238e-07 PITA;mirMAP -0.15210838630586 3.55664953396292e-12 NA NA NA hsa-miR-338-3p LIN9 0.399637046793888 0.00344106432206527 -0.25963678804965 4.28777630334232e-06 miRanda -0.118399987269949 8.18114917230414e-10 NA NA NA hsa-miR-330-5p LMAN2L 0.262932095995619 0.0465226565966542 -0.144180129529365 0.00104852423958073 miRanda -0.108982107164152 1.10869375619308e-23 NA NA NA hsa-miR-139-5p LMCD1 0.647754756897662 2.1537830723695e-06 -0.292141203716814 0.000293633067408679 miRanda -0.194168750244193 2.38637611867676e-14 NA NA NA hsa-miR-129-5p LMNA 0.567133990117154 0.00116152215679873 -0.341784447799117 3.50554676295192e-06 MirTarget;PITA;miRanda;miRNATAP -0.108566066856291 1.18497895152663e-10 NA NA NA hsa-miR-330-5p LMNB2 0.262932095995619 0.0465226565966542 -0.444318977527328 3.65344611171774e-13 MirTarget;miRanda -0.125844926814041 3.73785619602821e-13 NA NA NA hsa-miR-129-5p LMX1A 0.567133990117154 0.00116152215679873 0.8535826520379 0.000674129994829114 miRanda -0.208698323971722 0.0012086175303552 NA NA NA hsa-miR-330-5p LMX1B 0.262932095995619 0.0465226565966542 -0.000975113782978543 0.995748096125661 miRNATAP -0.196764365661411 0.00114403669165648 NA NA NA hsa-miR-338-3p LMX1B 0.399637046793888 0.00344106432206527 -0.000975113782978543 0.995748096125661 mirMAP -0.186783627760096 0.00361590925260381 NA NA NA hsa-miR-338-3p LONRF3 0.399637046793888 0.00344106432206527 -0.0460839162709059 0.699567478091848 miRanda -0.16635779215262 6.60546301784445e-05 NA NA NA hsa-miR-129-5p LOX 0.567133990117154 0.00116152215679873 -0.641848475047752 1.88910713929445e-09 miRanda -0.114718669667137 3.36637790814221e-05 NA NA NA hsa-miR-338-3p LOXL2 0.399637046793888 0.00344106432206527 -0.844032182250684 7.51211358348707e-13 miRanda -0.243197393191499 3.950304698454e-09 NA NA NA hsa-miR-330-5p LPCAT3 0.262932095995619 0.0465226565966542 -0.138963530031927 0.00922380087895569 miRanda -0.104084880510793 3.58298583244722e-12 NA NA NA hsa-miR-338-3p LPP 0.399637046793888 0.00344106432206527 -0.26512686457438 0.00469468941377865 miRanda;mirMAP -0.162640540733441 5.98970565592573e-07 NA NA NA hsa-miR-330-5p LRIG1 0.262932095995619 0.0465226565966542 0.391739433391736 3.34556271086365e-05 miRanda -0.120319941482237 1.90029714099354e-06 NA NA NA hsa-miR-330-5p LRIT2 0.262932095995619 0.0465226565966542 0.937896559968537 8.1615020301242e-11 miRanda -0.128813054739598 0.00840577685078525 NA NA NA hsa-miR-338-3p LRRC17 0.399637046793888 0.00344106432206527 -0.198097515224089 0.107305118570537 miRanda -0.183936995748887 1.64994215387442e-05 NA NA NA hsa-miR-129-5p LRRC36 0.567133990117154 0.00116152215679873 -0.811715891818902 8.72980585077716e-10 miRanda -0.135355956470938 7.98755229971291e-05 NA NA NA hsa-miR-338-3p LRRC36 0.399637046793888 0.00344106432206527 -0.811715891818902 8.72980585077716e-10 miRanda -0.157592118606075 0.000854508065677243 NA NA NA hsa-miR-138-5p LSM14A 0.61608764992087 1.35200027885651e-05 -0.135675532863164 0.0197385310025792 MirTarget;miRNATAP -0.109650058163427 2.56777522172665e-17 NA NA NA hsa-miR-139-5p LSM14A 0.647754756897662 2.1537830723695e-06 -0.135675532863164 0.0197385310025792 PITA;miRanda -0.135677508738625 1.96479521348079e-23 NA NA NA hsa-miR-330-3p LSM5 0.427388106938161 0.003004892844142 -0.169559449838988 0.000697894277007106 PITA -0.105046937737237 9.25562388903877e-17 NA NA NA hsa-miR-490-3p LTB4R 0.834268051506887 5.26203010743174e-06 -0.288298424195669 0.000126908106681569 miRanda -0.116579834276633 6.48242725844214e-11 NA NA NA hsa-miR-338-3p LTBP2 0.399637046793888 0.00344106432206527 -0.254075780257502 0.00279585762373014 miRanda -0.126841996234633 1.19278055328769e-05 NA NA NA hsa-miR-330-5p LTBP3 0.262932095995619 0.0465226565966542 0.0140031273217431 0.834965751828966 miRanda -0.15136504797331 1.72204191617917e-20 NA NA NA hsa-miR-330-5p LTBP4 0.262932095995619 0.0465226565966542 -0.29035000392502 0.0102885580786118 miRNATAP -0.11793926198601 0.000932003084844375 NA NA NA hsa-miR-490-3p LTBP4 0.834268051506887 5.26203010743174e-06 -0.29035000392502 0.0102885580786118 miRanda -0.129200451476961 4.79166461609787e-07 NA NA NA hsa-miR-129-5p LUM 0.567133990117154 0.00116152215679873 -0.71457751406496 5.60893764849197e-07 miRanda -0.146041434777813 7.39828217302776e-05 NA NA NA hsa-miR-129-5p MACC1 0.567133990117154 0.00116152215679873 -1.16615979223173 2.01680968398559e-12 mirMAP -0.208681027078624 1.02439665142429e-06 NA NA NA hsa-miR-330-3p MACC1 0.427388106938161 0.003004892844142 -1.16615979223173 2.01680968398559e-12 MirTarget;miRNATAP -0.139789954884807 0.00595218571776241 NA NA NA hsa-miR-485-3p MACC1 0.530677478972608 0.00148549219838864 -1.16615979223173 2.01680968398559e-12 mirMAP -0.176810227325734 5.01153878663423e-05 NA NA NA hsa-miR-139-5p MAD2L1 0.647754756897662 2.1537830723695e-06 -0.509480359167541 2.43743048341511e-11 miRanda -0.121316505097684 1.05404947489321e-06 NA NA NA hsa-miR-485-3p MAFB 0.530677478972608 0.00148549219838864 0.114209459435268 0.200239372859389 PITA;miRNATAP -0.106564984502269 7.94365287275364e-07 NA NA NA hsa-miR-129-5p MAK 0.567133990117154 0.00116152215679873 -0.586916961002266 9.48358817421518e-06 miRanda;miRNATAP -0.118295511839899 0.000501714351610324 NA NA NA hsa-miR-338-3p MAK 0.399637046793888 0.00344106432206527 -0.586916961002266 9.48358817421518e-06 miRanda -0.15052807390033 0.00128650857921246 NA NA NA hsa-miR-330-5p MAML2 0.262932095995619 0.0465226565966542 0.090575639674781 0.385843214879266 miRanda -0.157195488880705 1.28165156553027e-06 NA NA NA hsa-miR-139-5p MAP3K1 0.647754756897662 2.1537830723695e-06 -0.465982467733815 9.39781183614217e-11 miRanda -0.141771163672676 3.18554143822605e-10 NA NA NA hsa-miR-338-3p MAP3K1 0.399637046793888 0.00344106432206527 -0.465982467733815 9.39781183614217e-11 miRanda -0.128741986293352 9.99541924046903e-08 NA NA NA hsa-miR-139-5p MAP3K8 0.647754756897662 2.1537830723695e-06 -0.158077179723323 0.056374788751712 miRanda -0.142199211828712 1.17144015055053e-07 NA NA NA hsa-miR-330-5p MAPK7 0.262932095995619 0.0465226565966542 -0.148844494454936 0.00129551732110092 miRanda -0.138962935592789 3.09643389488675e-31 NA NA NA hsa-miR-485-3p MAPKAPK2 0.530677478972608 0.00148549219838864 -0.197884443595885 0.000243637469654382 MirTarget;PITA;miRNATAP -0.100951350110281 2.35175125442569e-22 NA NA NA hsa-miR-129-5p MAPRE1 0.567133990117154 0.00116152215679873 -0.0643232652215051 0.236023314226219 MirTarget;PITA;miRanda;miRNATAP -0.10203806482805 2.75354486498422e-33 NA NA NA hsa-miR-139-5p MAPRE1 0.647754756897662 2.1537830723695e-06 -0.0643232652215051 0.236023314226219 miRanda -0.119298479447277 5.08809176757297e-27 NA NA NA hsa-miR-129-5p MARCH3 0.567133990117154 0.00116152215679873 0.109352990517396 0.154472788197658 miRanda -0.112805532098423 6.79801649592737e-10 NA NA NA hsa-miR-338-3p MARCH3 0.399637046793888 0.00344106432206527 0.109352990517396 0.154472788197658 miRanda;miRNATAP -0.123821263601737 9.81986918853525e-07 NA NA NA hsa-miR-338-3p MARCKS 0.399637046793888 0.00344106432206527 0.10587779860699 0.190059303769629 miRanda -0.100896638419028 3.44587009301605e-06 NA NA NA hsa-miR-338-3p MASP1 0.399637046793888 0.00344106432206527 0.444098880254141 0.000153680527223851 miRanda -0.139947325501282 0.00036362391361528 NA NA NA hsa-miR-129-5p MATN2 0.567133990117154 0.00116152215679873 -0.378388920893883 0.000453134191975972 miRanda -0.109953598982302 2.57301185569798e-05 NA NA NA hsa-miR-490-3p MATN2 0.834268051506887 5.26203010743174e-06 -0.378388920893883 0.000453134191975972 miRanda -0.162542517709883 2.07172022296205e-11 NA NA NA hsa-miR-139-5p MBD2 0.647754756897662 2.1537830723695e-06 -0.228502660787934 3.66032603137039e-07 miRanda -0.114455763101801 1.82174336370565e-21 NA NA NA hsa-miR-490-3p MBD6 0.834268051506887 5.26203010743174e-06 -0.180011029753889 0.00539797180512655 PITA;miRanda -0.107169784529848 1.51203758771637e-15 NA NA NA hsa-miR-139-5p MBNL3 0.647754756897662 2.1537830723695e-06 -0.521693804968221 5.82570864849497e-05 MirTarget;PITA;miRanda -0.18001300990311 2.64607133327091e-05 NA NA NA hsa-miR-490-3p MBOAT1 0.834268051506887 5.26203010743174e-06 -0.454080388552435 7.53580457687649e-06 miRanda -0.113708750844709 3.46634260741478e-06 NA NA NA hsa-miR-139-5p MCL1 0.647754756897662 2.1537830723695e-06 -0.139308533735542 0.0460458083970209 miRanda -0.129046146202815 1.04049486522282e-14 NA NA NA hsa-miR-330-5p MCM10 0.262932095995619 0.0465226565966542 -1.41500674850917 3.12785674729591e-15 miRanda -0.264907589636668 1.40056685039516e-05 NA NA NA hsa-miR-338-5p MCM10 0.424003687569646 0.00246415720301228 -1.41500674850917 3.12785674729591e-15 MirTarget -0.23199519633011 6.51677302790155e-05 NA NA NA hsa-miR-490-3p MCM10 0.834268051506887 5.26203010743174e-06 -1.41500674850917 3.12785674729591e-15 miRanda -0.221055825865915 5.36467938032584e-07 NA NA NA hsa-miR-139-5p MCM2 0.647754756897662 2.1537830723695e-06 -0.719968273129613 2.1310384080773e-17 miRanda -0.199905099988402 2.15355073551115e-13 NA NA NA hsa-miR-490-3p MCM5 0.834268051506887 5.26203010743174e-06 -0.432885876193859 2.31259241188133e-12 miRanda -0.120441448842492 3.86416434500974e-19 NA NA NA hsa-miR-330-5p MCM9 0.262932095995619 0.0465226565966542 -0.19474405350987 0.000620120336915576 miRanda -0.111480451286514 2.31569577092041e-09 NA NA NA hsa-miR-129-5p MCOLN2 0.567133990117154 0.00116152215679873 -0.628524505469283 8.08910851946924e-05 miRanda;mirMAP -0.174003146381516 2.0660492126381e-05 NA NA NA hsa-miR-139-5p MDM1 0.647754756897662 2.1537830723695e-06 -0.0053408166000084 0.924646416538267 miRanda -0.108346281468839 6.97258976167961e-11 NA NA NA hsa-miR-139-5p MECOM 0.647754756897662 2.1537830723695e-06 -0.439232920196769 6.12423327640271e-08 miRanda -0.110094703039059 3.43467705567743e-05 NA NA NA hsa-miR-338-3p MED20 0.399637046793888 0.00344106432206527 -0.0924925003003603 0.0432735736910916 miRanda -0.115048811265579 5.19303793437222e-20 NA NA NA hsa-miR-485-3p MELK 0.530677478972608 0.00148549219838864 -1.72442418646277 1.04315199775138e-20 MirTarget -0.203376831220958 4.64775994790988e-05 NA NA NA hsa-miR-330-5p MEST 0.262932095995619 0.0465226565966542 -0.577340808103821 7.5694260374867e-10 miRanda;miRNATAP -0.116775205022344 0.000108533710450469 NA NA NA hsa-miR-129-5p MEX3A 0.567133990117154 0.00116152215679873 -0.257045108430414 0.015872951129435 MirTarget;PITA;miRanda;miRNATAP -0.14127972556906 3.4059340182224e-08 NA NA NA hsa-miR-139-5p MEX3A 0.647754756897662 2.1537830723695e-06 -0.257045108430414 0.015872951129435 PITA;miRanda;miRNATAP -0.182820967200668 2.97681006238569e-08 NA NA NA hsa-miR-338-3p MICB 0.399637046793888 0.00344106432206527 -0.615650451447751 3.99540843471903e-10 miRanda -0.136999830685291 9.66462145602131e-05 NA NA NA hsa-miR-490-3p MICB 0.834268051506887 5.26203010743174e-06 -0.615650451447751 3.99540843471903e-10 miRanda -0.161223058141117 1.00825359605419e-11 NA NA NA hsa-miR-338-3p MID1 0.399637046793888 0.00344106432206527 -0.0400211535004793 0.589642704179098 miRanda -0.131830398748233 6.75192056668257e-08 NA NA NA hsa-miR-129-5p MIDN 0.567133990117154 0.00116152215679873 -0.216195118054372 0.00233464005554776 miRanda -0.151519072403008 1.9177339710257e-27 NA NA NA hsa-miR-139-5p MIDN 0.647754756897662 2.1537830723695e-06 -0.216195118054372 0.00233464005554776 miRanda -0.176707769341791 2.55322905155282e-22 NA NA NA hsa-miR-485-3p MIDN 0.530677478972608 0.00148549219838864 -0.216195118054372 0.00233464005554776 miRNATAP -0.136683364136223 2.07588310514619e-21 NA NA NA hsa-miR-129-5p MIR155HG 0.567133990117154 0.00116152215679873 -0.814443254567091 3.36759593461703e-10 miRanda -0.156536224024463 2.3721075770847e-07 NA NA NA hsa-miR-490-3p MIR155HG 0.834268051506887 5.26203010743174e-06 -0.814443254567091 3.36759593461703e-10 miRanda -0.144710756268754 3.82132044877609e-07 NA NA NA hsa-miR-129-5p MIR17HG 0.567133990117154 0.00116152215679873 0.010825790288459 0.912860864114524 miRanda -0.123279688032227 9.08907690978861e-07 NA NA NA hsa-miR-129-5p MLKL 0.567133990117154 0.00116152215679873 -0.321512597301636 2.57911942980498e-05 miRanda -0.110182610188973 1.45163865173935e-08 NA NA NA hsa-miR-330-3p MMP16 0.427388106938161 0.003004892844142 -0.0614622118586503 0.591682570911417 PITA;mirMAP -0.100887292436988 0.0026463864427337 NA NA NA hsa-miR-330-5p MMP16 0.262932095995619 0.0465226565966542 -0.0614622118586503 0.591682570911417 PITA;miRanda -0.106028228359213 0.0040216964569017 NA NA NA hsa-miR-129-5p MMP19 0.567133990117154 0.00116152215679873 -0.0878702855749234 0.172105086985616 MirTarget;miRanda -0.122359230194612 6.97382523040227e-17 NA NA NA hsa-miR-330-3p MMP2 0.427388106938161 0.003004892844142 -0.704014978384594 1.08365653245423e-12 miRNATAP -0.172460053047175 1.96068699785787e-09 NA NA NA hsa-miR-338-3p MMP2 0.399637046793888 0.00344106432206527 -0.704014978384594 1.08365653245423e-12 miRNAWalker2_validate -0.202105497786416 1.49953035141337e-09 NA NA NA hsa-miR-129-5p MMP7 0.567133990117154 0.00116152215679873 -0.697543155810098 0.00324788941211663 miRanda -0.25155384306286 3.16357442904307e-05 NA NA NA hsa-miR-338-3p MMP9 0.399637046793888 0.00344106432206527 -1.2919772209203 2.47212900840831e-08 miRNAWalker2_validate -0.474310894093808 6.18854632467067e-09 NA NA NA hsa-miR-139-5p MNX1 0.647754756897662 2.1537830723695e-06 -0.746355647965273 0.000936082396895356 miRanda -0.249069045568548 0.000825938143978996 NA NA NA hsa-miR-338-3p MNX1 0.399637046793888 0.00344106432206527 -0.746355647965273 0.000936082396895356 miRanda -0.257755615557681 0.00118030040714291 NA NA NA hsa-miR-338-5p MNX1 0.424003687569646 0.00246415720301228 -0.746355647965273 0.000936082396895356 miRNATAP -0.249786215731033 0.000456019613171373 NA NA NA hsa-miR-129-5p MORC4 0.567133990117154 0.00116152215679873 -0.237762395894071 8.20472925437117e-06 miRanda -0.11093801431238 1.64879164641528e-20 NA NA NA hsa-miR-138-5p MOV10 0.61608764992087 1.35200027885651e-05 -0.310633126595345 5.47469034952456e-06 MirTarget;miRNATAP -0.176499754078797 2.17594094768508e-20 NA NA NA hsa-miR-490-3p MOV10 0.834268051506887 5.26203010743174e-06 -0.310633126595345 5.47469034952456e-06 miRanda -0.116106568415688 9.28116131905786e-15 NA NA NA hsa-miR-330-5p MPST 0.262932095995619 0.0465226565966542 0.0156674005714121 0.807489953889395 miRanda -0.159087694188296 7.26295464088406e-19 NA NA NA hsa-miR-139-5p MPZL1 0.647754756897662 2.1537830723695e-06 -0.235683267464999 0.000386491969365372 miRanda -0.153219960720573 1.35718659759798e-19 NA NA NA hsa-miR-129-5p MPZL2 0.567133990117154 0.00116152215679873 -0.861823735369938 1.8065973411097e-09 miRanda -0.111863441059194 0.00269971329593087 NA NA NA hsa-miR-139-5p MPZL2 0.647754756897662 2.1537830723695e-06 -0.861823735369938 1.8065973411097e-09 miRanda -0.187862040645443 8.80198274176421e-05 NA NA NA hsa-miR-490-3p MPZL2 0.834268051506887 5.26203010743174e-06 -0.861823735369938 1.8065973411097e-09 miRanda -0.123832773204861 0.000404144122756914 NA NA NA hsa-miR-139-5p MR1 0.647754756897662 2.1537830723695e-06 -0.388686228267074 1.16318017133597e-05 miRanda -0.195079544924519 1.13317238548837e-11 NA NA NA hsa-miR-490-3p MREG 0.834268051506887 5.26203010743174e-06 -0.306797409600385 7.67322387564605e-05 miRanda -0.100102706915887 2.45542615255842e-08 NA NA NA hsa-miR-139-5p MRPL42 0.647754756897662 2.1537830723695e-06 -0.2114209983662 4.05770241132065e-06 MirTarget;miRanda -0.108668689844064 1.58108854458003e-18 NA NA NA hsa-miR-330-3p MRPL42 0.427388106938161 0.003004892844142 -0.2114209983662 4.05770241132065e-06 mirMAP -0.104597030662148 1.99873683982687e-20 NA NA NA hsa-miR-129-5p MS4A14 0.567133990117154 0.00116152215679873 -0.148631927188015 0.205523116108893 miRanda -0.152059267792529 3.19911332203001e-07 NA NA NA hsa-miR-139-5p MS4A14 0.647754756897662 2.1537830723695e-06 -0.148631927188015 0.205523116108893 miRanda -0.289429732845728 1.76697510290737e-14 NA NA NA hsa-miR-129-5p MS4A4A 0.567133990117154 0.00116152215679873 -0.405601327194598 0.00139381779185526 miRanda -0.272063936510458 2.57595294019379e-18 NA NA NA hsa-miR-330-5p MS4A6A 0.262932095995619 0.0465226565966542 -0.913878109205792 2.59692461717674e-09 miRanda -0.238225365439158 2.64862762330912e-06 NA NA NA hsa-miR-330-5p MSH5 0.262932095995619 0.0465226565966542 -0.410755695385268 1.75448823941446e-05 miRanda -0.256602847026508 6.53796957590649e-17 NA NA NA hsa-miR-490-3p MSI1 0.834268051506887 5.26203010743174e-06 -0.171112848900031 0.00541191656449376 MirTarget;PITA;miRanda;miRNATAP -0.140508893621995 1.17398834287406e-30 NA NA NA hsa-miR-129-5p MSR1 0.567133990117154 0.00116152215679873 -0.834334412557248 6.24011046031341e-10 miRanda -0.255555918147603 6.51999622506165e-14 NA NA NA hsa-miR-338-3p MSR1 0.399637046793888 0.00344106432206527 -0.834334412557248 6.24011046031341e-10 miRanda -0.159764659083023 0.000843147989202764 NA NA NA hsa-miR-338-5p MSR1 0.424003687569646 0.00246415720301228 -0.834334412557248 6.24011046031341e-10 mirMAP -0.102320613570131 0.0175034537247703 NA NA NA hsa-miR-129-5p MSTN 0.567133990117154 0.00116152215679873 0.200420694909308 0.307973616550615 miRanda -0.134262417423971 0.00715295712312382 NA NA NA hsa-miR-330-5p MSTN 0.262932095995619 0.0465226565966542 0.200420694909308 0.307973616550615 miRanda -0.360297433391498 1.78776840190694e-08 NA NA NA hsa-miR-338-5p MSTN 0.424003687569646 0.00246415720301228 0.200420694909308 0.307973616550615 MirTarget;PITA;miRNATAP -0.192432517195207 0.00175449534844238 NA NA NA hsa-miR-490-3p MSTN 0.834268051506887 5.26203010743174e-06 0.200420694909308 0.307973616550615 miRanda -0.188547984293758 5.48866451732218e-05 NA NA NA hsa-miR-330-5p MSTO2P 0.262932095995619 0.0465226565966542 -0.148492889423552 0.0289142345028456 miRanda -0.130519717900845 2.54792883344583e-09 NA NA NA hsa-miR-129-5p MSX1 0.567133990117154 0.00116152215679873 -0.219783037589468 0.00852007022949166 miRanda -0.106010234354949 1.92428686822161e-07 NA NA NA hsa-miR-139-5p MSX1 0.647754756897662 2.1537830723695e-06 -0.219783037589468 0.00852007022949166 miRanda -0.191136669702169 1.5952910376793e-13 NA NA NA hsa-miR-330-5p MT1X 0.262932095995619 0.0465226565966542 0.285246250927465 0.0338565572447731 miRanda -0.183476932470608 1.2903627216674e-05 NA NA NA hsa-miR-129-5p MTBP 0.567133990117154 0.00116152215679873 -0.456663343243346 4.5690352618379e-10 miRanda -0.117515407109113 4.12530383243095e-10 NA NA NA hsa-miR-139-5p MTBP 0.647754756897662 2.1537830723695e-06 -0.456663343243346 4.5690352618379e-10 miRanda -0.188019397517758 4.4736080948653e-15 NA NA NA hsa-miR-138-1-3p MTHFD2 0.446369405595197 0.000598407910928167 0.311990971843933 0.00555875885746083 mirMAP -0.174469383922491 1.00308446111416e-06 NA NA NA hsa-miR-330-5p MUC1 0.262932095995619 0.0465226565966542 -0.400551315919138 1.84919243243738e-05 miRanda -0.115325294578743 0.000204850932988116 26036346 Our in vitro and in vivo experiments indicate that miR-29a and miR-330-5p are strong inhibitors of MUC1 expression in pancreatic cancer cells through direct binding to MUC1 3'-UTR; Altogether we have identified miR-29a and miR-330-5p as two new tumor suppressive miRNAs that inhibit the expression of MUC1 oncogenic mucin in pancreatic cancer cells pancreatic cancer hsa-miR-490-3p MUC1 0.834268051506887 5.26203010743174e-06 -0.400551315919138 1.84919243243738e-05 miRanda -0.181200107029704 1.55007458206715e-16 NA NA NA hsa-miR-139-5p MXD3 0.647754756897662 2.1537830723695e-06 -0.522360560716323 4.92371735296071e-11 miRanda -0.181172260222067 2.08521320730824e-12 NA NA NA hsa-miR-139-5p MXRA5 0.647754756897662 2.1537830723695e-06 -0.67212243073026 5.83516238034291e-06 miRanda -0.284400242816402 4.89479403446541e-09 NA NA NA hsa-miR-139-5p MYCBP 0.647754756897662 2.1537830723695e-06 -0.336131876026709 3.41169014469493e-07 MirTarget;miRanda -0.209762058756724 2.90908984560853e-25 NA NA NA hsa-miR-485-3p MYCN 0.530677478972608 0.00148549219838864 0.0727164386918853 0.479635667277214 miRNATAP -0.121703147665888 2.66896585749176e-06 NA NA NA hsa-miR-138-5p MYD88 0.61608764992087 1.35200027885651e-05 -0.413794389705457 3.45628586506132e-06 MirTarget -0.14950820343919 1.68371091611091e-08 NA NA NA hsa-miR-490-3p NAGA 0.834268051506887 5.26203010743174e-06 -0.265630195549823 3.48437738526062e-05 miRanda -0.102608984165766 1.5332917125305e-13 NA NA NA hsa-miR-129-5p NAMPT 0.567133990117154 0.00116152215679873 -0.552593554725036 2.88461915268163e-10 miRanda -0.126830585759816 1.99216178268073e-09 NA NA NA hsa-miR-338-5p NAMPT 0.424003687569646 0.00246415720301228 -0.552593554725036 2.88461915268163e-10 miRNATAP -0.122583452678565 3.03382268817726e-06 NA NA NA hsa-miR-139-5p NANP 0.647754756897662 2.1537830723695e-06 -0.340003906242937 3.47495796304994e-10 miRanda -0.119489565853855 2.72596150005247e-12 NA NA NA hsa-miR-338-3p NBEAL1 0.399637046793888 0.00344106432206527 -0.00828409414759812 0.942841571307029 miRanda -0.12718061585342 0.0016960626281309 NA NA NA hsa-miR-129-5p NCAPG 0.567133990117154 0.00116152215679873 -1.6338048045306 5.1237480732658e-20 miRanda -0.266504063986124 1.31000652315943e-08 NA NA NA hsa-miR-490-3p NCAPH 0.834268051506887 5.26203010743174e-06 -1.30355702288534 9.95622404575083e-23 miRanda -0.175858422927792 1.06457505485928e-07 NA NA NA hsa-miR-139-5p NDOR1 0.647754756897662 2.1537830723695e-06 -0.138798574508115 0.0083584359490043 mirMAP -0.138017215991839 1.2288090388242e-21 NA NA NA hsa-miR-129-5p NEDD1 0.567133990117154 0.00116152215679873 -0.325047943870311 1.54152874598847e-07 miRanda -0.128853435600603 3.23941205684745e-20 NA NA NA hsa-miR-338-5p NEDD1 0.424003687569646 0.00246415720301228 -0.325047943870311 1.54152874598847e-07 miRNATAP -0.124453157621494 1.27802554805456e-12 NA NA NA hsa-miR-129-5p NEDD4 0.567133990117154 0.00116152215679873 -0.157771080674817 0.0673814400636771 miRanda;mirMAP -0.131675011973906 2.03392575115878e-10 NA NA NA hsa-miR-330-3p NEDD4 0.427388106938161 0.003004892844142 -0.157771080674817 0.0673814400636771 mirMAP -0.133761442241476 5.28362328323057e-08 NA NA NA hsa-miR-338-5p NEDD4 0.424003687569646 0.00246415720301228 -0.157771080674817 0.0673814400636771 mirMAP -0.129800563615161 4.51909073239065e-07 NA NA NA hsa-miR-139-5p NFATC1 0.647754756897662 2.1537830723695e-06 -0.204786711368577 0.051194948863733 miRanda -0.256587875136984 2.02892529769674e-14 NA NA NA hsa-miR-139-5p NFE2L2 0.647754756897662 2.1537830723695e-06 -0.12057206077382 0.0229932819455776 miRanda -0.107142294730015 7.14555393844587e-20 NA NA NA hsa-miR-139-5p NFE2L3 0.647754756897662 2.1537830723695e-06 -0.380288012736312 1.09733725179661e-06 miRanda -0.178937449620272 2.00217374261326e-12 NA NA NA hsa-miR-139-5p NFIA 0.647754756897662 2.1537830723695e-06 -0.00716777603260788 0.932453297980209 miRanda;miRNATAP -0.191493714437037 3.40941480382673e-16 NA NA NA hsa-miR-338-3p NFIA 0.399637046793888 0.00344106432206527 -0.00716777603260788 0.932453297980209 miRNATAP -0.142227120647798 2.30563591929865e-08 NA NA NA hsa-miR-138-5p NFIB 0.61608764992087 1.35200027885651e-05 0.151336169908435 0.0298860513853786 miRNATAP -0.119145068140554 1.42900410001137e-11 NA NA NA hsa-miR-330-5p NFIX 0.262932095995619 0.0465226565966542 0.0599097341463874 0.398873818686894 PITA;mirMAP -0.121980955968978 5.87381598451349e-15 NA NA NA hsa-miR-330-5p NFKBIL1 0.262932095995619 0.0465226565966542 0.0557305380538091 0.332289141674022 miRanda -0.126879753508951 8.25673200377119e-15 NA NA NA hsa-miR-139-5p NGFR 0.647754756897662 2.1537830723695e-06 -0.822316760131141 1.12739936860329e-08 miRanda -0.111941275424144 0.0192344531873393 NA NA NA hsa-miR-338-3p NHLRC2 0.399637046793888 0.00344106432206527 -0.0897780474180934 0.351578616517323 miRanda -0.13263958116459 7.70045107941107e-05 NA NA NA hsa-miR-338-3p NHSL1 0.399637046793888 0.00344106432206527 0.205024213648941 0.00374996295970456 miRanda;miRNATAP -0.117831144424252 2.27485391244918e-07 NA NA NA hsa-miR-330-5p NID1 0.262932095995619 0.0465226565966542 -0.426636719335625 1.45299433943869e-05 miRanda -0.157125275157854 4.06496702692022e-07 NA NA NA hsa-miR-485-3p NID1 0.530677478972608 0.00148549219838864 -0.426636719335625 1.45299433943869e-05 PITA -0.131885788308089 5.67546391356406e-08 NA NA NA hsa-miR-129-5p NID2 0.567133990117154 0.00116152215679873 -0.59547652892585 3.90503577160159e-08 PITA;miRanda;miRNATAP -0.188221172882602 6.12126003352395e-12 NA NA NA hsa-miR-139-5p NID2 0.647754756897662 2.1537830723695e-06 -0.59547652892585 3.90503577160159e-08 miRanda -0.240403353241968 9.56248540492737e-12 NA NA NA hsa-miR-490-3p NID2 0.834268051506887 5.26203010743174e-06 -0.59547652892585 3.90503577160159e-08 miRanda -0.17532297337157 9.86485473772406e-12 NA NA NA hsa-miR-330-5p NKD1 0.262932095995619 0.0465226565966542 0.0915570732498789 0.331718005040298 miRanda;miRNATAP -0.12931550105749 1.67983789674822e-05 NA NA NA hsa-miR-330-5p NKIRAS2 0.262932095995619 0.0465226565966542 -0.30712257136225 1.54887314183599e-08 miRanda -0.15361371928213 5.95725847706254e-27 NA NA NA hsa-miR-139-5p NKX3-2 0.647754756897662 2.1537830723695e-06 -1.29365278430428 1.48215082280085e-12 miRanda -0.38874545462554 1.72836871160057e-10 NA NA NA hsa-miR-330-5p NLGN1 0.262932095995619 0.0465226565966542 0.113683923784954 0.082745758579932 miRanda -0.119334528271683 3.20507894095467e-10 NA NA NA hsa-miR-129-5p NMI 0.567133990117154 0.00116152215679873 -0.445414568864253 2.68717885445642e-07 miRanda -0.139418006104907 1.86648729020002e-10 NA NA NA hsa-miR-139-5p NMI 0.647754756897662 2.1537830723695e-06 -0.445414568864253 2.68717885445642e-07 miRanda -0.283203399951091 3.70552297239956e-25 NA NA NA hsa-miR-490-3p NMI 0.834268051506887 5.26203010743174e-06 -0.445414568864253 2.68717885445642e-07 miRanda -0.146636619222208 7.92072375499919e-13 NA NA NA hsa-miR-330-5p NOB1 0.262932095995619 0.0465226565966542 -0.0522870056142315 0.29004834085163 miRanda -0.109533344377536 1.00282581582612e-18 NA NA NA hsa-miR-490-3p NOD1 0.834268051506887 5.26203010743174e-06 -0.258641787963299 4.60074807933438e-05 miRanda -0.106091511399401 5.79801073031784e-13 NA NA NA hsa-miR-338-3p NOD2 0.399637046793888 0.00344106432206527 -0.16804811259478 0.104124440920063 miRanda -0.139204386437224 0.000128242992270082 NA NA NA hsa-miR-330-5p NONO 0.262932095995619 0.0465226565966542 -0.100097582683073 0.104822233685634 miRanda -0.132800615246896 1.68054570365909e-26 NA NA NA hsa-miR-490-3p NOP2 0.834268051506887 5.26203010743174e-06 -0.21821709802297 2.27939322269597e-05 miRanda -0.1015571058651 4.07534748143479e-24 NA NA NA hsa-miR-139-5p NOTCH1 0.647754756897662 2.1537830723695e-06 0.0216757814444195 0.784456320866547 PITA;miRanda;miRNATAP -0.126275438431501 3.97588150952362e-09 27173050;25149074;26299922;27738333;24885920 miR 139 5p sensitizes colorectal cancer cells to 5 fluorouracil by targeting NOTCH 1;MiR 139 5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1; Mechanistic investigations revealed that miR-139-5p suppress CRC cell invasion and metastasis by targeting AMFR and NOTCH1;MiR 139 5p inhibits the biological function of breast cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel; MiR-139-5p expression in MCF-7 MCF-7/Doc cells and in selected breast cancer tissue samples was confirmed by real-time PCR; cell viability was analyzed by Cell Counting Kit-8 assay; apoptosis and cell cycle were analyzed by flow cytometry; control of metastasis and invasion of breast cancer cells was measured by transwell assay; expression of Notch1 was measured by western blot; a luciferase reporter vector was constructed to identify the miR-139-5p target gene; MiR-139-5p not only attenuated the development of breast cancer cells but also mediated drug-resistance by regulating the expression of the downstream target gene Notch1;MiR 139 5p reverses CD44+/CD133+ associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells; We also identified NOTCH1 an important protein for stem cell maintenance and function as a direct target of miR-139-5p both in vitro and in a knockout mouse model; Notch1 expression was upregulated in tumor samples and inversely correlated with expression of miR-139-5p; Silencing NOTCH1 exerted an effect similar to overexpression of miR-139-5p by inhibiting the CD44+ and CD133+ population and reversing the drug-resistant phenotype; In conclusion miR-139-5p downregulated NOTCH1 signaling to reverse CD44+/CD133+-associated MDR in colorectal cancer cells;microRNA 139 5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer ;metastasis;metastasis;drug resistance;drug resistance; colorectal cancer;colorectal cancer;breast cancer;colorectal cancer;colorectal cancer hsa-miR-139-5p NOTCH2NL 0.647754756897662 2.1537830723695e-06 0.0730571834862355 0.287337942915309 PITA;miRanda -0.110319198042615 4.81386052309305e-08 NA NA NA hsa-miR-330-5p NPAS3 0.262932095995619 0.0465226565966542 0.125692939469159 0.0417128993506105 miRanda;miRNATAP -0.10083423782909 5.26944297570802e-10 NA NA NA hsa-miR-129-5p NPC2 0.567133990117154 0.00116152215679873 -0.198810162878174 0.014435266606274 MirTarget -0.130751103161727 2.76022183258609e-12 NA NA NA hsa-miR-490-3p NR2C2AP 0.834268051506887 5.26203010743174e-06 -0.323110074216332 4.04380353801668e-10 miRanda -0.107155596392138 1.5867816212824e-21 NA NA NA hsa-miR-338-3p NR4A3 0.399637046793888 0.00344106432206527 -0.422341048767815 0.000596983336447018 miRanda -0.121090373637873 0.00483845508612806 NA NA NA hsa-miR-139-5p NR5A2 0.647754756897662 2.1537830723695e-06 -0.890254490803871 3.4591266606211e-08 PITA;miRanda -0.4920980140631 2.78980588181853e-21 24204738 The mRNA level of NR5A2 the target gene of miR-139-5p was determined in ESCC patients; MiR-139-5p was investigated to induce cell cycle arrest in the G0/G1 phase and to suppress the invasive capability of esophageal carcinoma cells by targeting the 3'UTR of oncogenic NR5A2; Pearson correlation analysis further confirmed the significantly negative correlation between miR-139-5p and NR5A2 expression esophageal cancer hsa-miR-330-5p NR5A2 0.262932095995619 0.0465226565966542 -0.890254490803871 3.4591266606211e-08 PITA -0.329324739357108 7.86702912970618e-10 NA NA NA hsa-miR-338-5p NR5A2 0.424003687569646 0.00246415720301228 -0.890254490803871 3.4591266606211e-08 PITA;miRNATAP -0.30044586425646 3.93616111637157e-09 NA NA NA hsa-miR-330-5p NRARP 0.262932095995619 0.0465226565966542 0.317818608527375 0.000274851825605879 MirTarget;miRanda -0.17486149239512 9.26461545865606e-11 NA NA NA hsa-miR-139-5p NRP1 0.647754756897662 2.1537830723695e-06 -0.396588120850163 2.31974702580454e-07 PITA;miRanda -0.115547614211175 1.52784439791969e-06 NA NA NA hsa-miR-338-3p NRP1 0.399637046793888 0.00344106432206527 -0.396588120850163 2.31974702580454e-07 PITA;miRanda;miRNATAP -0.127469549013589 6.4738193339499e-07 24736504 MicroRNA 338 inhibits growth invasion and metastasis of gastric cancer by targeting NRP1 expression; Moreover we found that miR-338 inhibited gastric cancer cell migration invasion proliferation and promoted apoptosis by targeting NRP1 expression; As an upstream regulator of NRP1 miR-338 directly targets NRP1; The forced expression of miR-338 inhibited the phosphorylation of Erk1/2 P38 MAPK and Akt; however the expression of phosphorylated Erk1/2 P38 MAPK and Akt was restored by the overexpression of NRP1; In vivo miR-338 also decreased tumor growth and suppressed D-MVA by targeting NRP1; miR-338 can decrease migratory invasive proliferative and apoptotic behaviors as well as gastric cancer EMT by attenuating the expression of NRP1 metastasis;cell migration gastric cancer hsa-miR-129-5p NSUN5P2 0.567133990117154 0.00116152215679873 -0.169822387622816 0.0498557072361638 miRanda -0.102231938847106 1.67652834447272e-06 NA NA NA hsa-miR-129-5p NSUN7 0.567133990117154 0.00116152215679873 -0.770760949546328 2.51595941676804e-07 miRanda -0.101224730764842 0.00901637190178024 NA NA NA hsa-miR-330-5p NTN1 0.262932095995619 0.0465226565966542 -0.230577873621963 0.0100391058601805 PITA;miRanda;miRNATAP -0.221380953603875 6.55796591960899e-17 NA NA NA hsa-miR-139-5p NUDT19 0.647754756897662 2.1537830723695e-06 -0.213622000765768 3.09393261509414e-05 miRanda -0.11019942329928 1.19186472594664e-12 NA NA NA hsa-miR-139-5p NUP107 0.647754756897662 2.1537830723695e-06 -0.253833537062199 6.34109832352091e-07 miRanda -0.168868237850814 7.41832069285878e-35 NA NA NA hsa-miR-139-5p NUP160 0.647754756897662 2.1537830723695e-06 -0.184917972681883 0.00076004095910411 miRanda -0.133724222721074 1.29368063337085e-19 NA NA NA hsa-miR-338-3p NUP205 0.399637046793888 0.00344106432206527 -0.241678512390165 1.14694175113115e-05 miRanda -0.148259231186378 9.02641879317703e-22 NA NA NA hsa-miR-139-5p NUP37 0.647754756897662 2.1537830723695e-06 -0.265165459265281 2.45946621043472e-09 miRanda -0.186202732131485 5.60930431662098e-50 NA NA NA hsa-miR-330-3p NUP43 0.427388106938161 0.003004892844142 -0.0994367028343612 0.0237323670809771 mirMAP -0.109667853915468 6.34595213183134e-26 NA NA NA hsa-miR-490-3p OAS1 0.834268051506887 5.26203010743174e-06 -0.585783882264332 1.4939229366526e-06 miRanda -0.100169734822574 0.000665902440204299 NA NA NA hsa-miR-139-5p OAS2 0.647754756897662 2.1537830723695e-06 -0.646827495090048 7.5271972329676e-09 miRanda -0.205422278287 2.40245574452859e-08 NA NA NA hsa-miR-138-5p OAS3 0.61608764992087 1.35200027885651e-05 -0.476505986488794 1.01093429474311e-05 miRNATAP -0.131436719629714 7.47018588804762e-05 NA NA NA hsa-miR-139-5p OAS3 0.647754756897662 2.1537830723695e-06 -0.476505986488794 1.01093429474311e-05 mirMAP -0.145901683686063 3.53228944475523e-05 NA NA NA hsa-miR-338-3p OAS3 0.399637046793888 0.00344106432206527 -0.476505986488794 1.01093429474311e-05 miRanda -0.104586968959344 0.00565039256827065 NA NA NA hsa-miR-490-3p OASL 0.834268051506887 5.26203010743174e-06 -0.776988589159952 1.11393392618945e-07 PITA;miRanda -0.121018631945349 0.000690782608702561 NA NA NA hsa-miR-139-5p OIP5 0.647754756897662 2.1537830723695e-06 -1.04229258930529 1.22505979054621e-19 miRanda -0.331000291001541 4.13164577205178e-18 NA NA NA hsa-miR-330-3p ONECUT2 0.427388106938161 0.003004892844142 -0.0592720542393952 0.626992163670138 PITA;miRNATAP -0.172032082823349 2.36716399185494e-06 NA NA NA hsa-miR-338-3p ONECUT2 0.399637046793888 0.00344106432206527 -0.0592720542393952 0.626992163670138 PITA -0.150055713380498 0.00043065733420885 NA NA NA hsa-miR-330-5p OPHN1 0.262932095995619 0.0465226565966542 0.470732943812718 1.62843731556359e-06 miRanda -0.202110571201737 4.25457825476495e-12 NA NA NA hsa-miR-338-3p OPHN1 0.399637046793888 0.00344106432206527 0.470732943812718 1.62843731556359e-06 mirMAP -0.113470976830861 0.000306759725765791 NA NA NA hsa-miR-139-5p ORAI3 0.647754756897662 2.1537830723695e-06 -0.0508880684616102 0.281009315015105 miRanda -0.124921852529879 1.14449772968747e-21 NA NA NA hsa-miR-490-3p OS9 0.834268051506887 5.26203010743174e-06 -0.282786909096918 8.33400983110641e-05 miRanda -0.109598515691534 1.43453222860252e-16 NA NA NA hsa-miR-139-5p OSBPL9 0.647754756897662 2.1537830723695e-06 0.00596919257331496 0.936978417180957 miRanda -0.102455738514797 3.565369989736e-06 NA NA NA hsa-miR-139-5p OSCAR 0.647754756897662 2.1537830723695e-06 -0.268755237485861 0.00565016942953013 miRanda -0.258525373575752 1.34494581744927e-16 NA NA NA hsa-miR-338-3p OSM 0.399637046793888 0.00344106432206527 -0.470952885273384 0.00656704512504148 miRanda -0.134591967519997 0.027987037545887 NA NA NA hsa-miR-139-5p OSMR 0.647754756897662 2.1537830723695e-06 -0.702146516650026 1.45970893157116e-08 miRanda -0.211914432735387 1.96756060590983e-07 NA NA NA hsa-miR-129-5p OSR2 0.567133990117154 0.00116152215679873 -1.79618424895259 2.83986089771601e-15 miRanda -0.200433965038849 0.000774556309336763 NA NA NA hsa-miR-139-5p OSR2 0.647754756897662 2.1537830723695e-06 -1.79618424895259 2.83986089771601e-15 PITA;miRanda -0.551985408287368 2.30773113485161e-13 NA NA NA hsa-miR-330-3p OSR2 0.427388106938161 0.003004892844142 -1.79618424895259 2.83986089771601e-15 PITA -0.147065521609077 0.0373782700040903 NA NA NA hsa-miR-338-3p OXTR 0.399637046793888 0.00344106432206527 -0.404874884429514 0.00757075795358678 miRanda -0.234564708398076 8.30478936349272e-06 NA NA NA hsa-miR-485-3p P4HA3 0.530677478972608 0.00148549219838864 -0.545231239979411 2.8572929294637e-05 MirTarget -0.117654255356427 0.000507328846937579 NA NA NA hsa-miR-129-5p PABPC1 0.567133990117154 0.00116152215679873 -0.019593434971739 0.807522366815322 miRanda;miRNATAP -0.103745059802271 3.81794756260046e-11 NA NA NA hsa-miR-139-5p PABPC1 0.647754756897662 2.1537830723695e-06 -0.019593434971739 0.807522366815322 miRanda -0.119807334007051 3.64670697641753e-09 NA NA NA hsa-miR-129-5p PABPC1L 0.567133990117154 0.00116152215679873 -0.575363841037974 8.43918621540285e-07 miRanda -0.1594044299681 8.41331960066643e-08 NA NA NA hsa-miR-330-3p PABPC1L 0.427388106938161 0.003004892844142 -0.575363841037974 8.43918621540285e-07 miRNATAP -0.143967123150445 4.622856831746e-05 NA NA NA hsa-miR-330-5p PABPC1L 0.262932095995619 0.0465226565966542 -0.575363841037974 8.43918621540285e-07 miRanda -0.176311364237411 5.28498350327894e-06 NA NA NA hsa-miR-129-5p PABPC3 0.567133990117154 0.00116152215679873 -0.0961041771504201 0.191020878774019 miRanda -0.115265681120154 2.07543802173136e-10 NA NA NA hsa-miR-338-5p PABPC4L 0.424003687569646 0.00246415720301228 -0.670273705218317 8.64226509153207e-12 MirTarget -0.110784671696376 0.000433731344947527 NA NA NA hsa-miR-330-5p PAG1 0.262932095995619 0.0465226565966542 -0.0841644243646007 0.183893054018381 MirTarget;PITA -0.124071358216325 8.71088971595683e-13 NA NA NA hsa-miR-485-3p PAG1 0.530677478972608 0.00148549219838864 -0.0841644243646007 0.183893054018381 MirTarget -0.103348852002717 2.65685720490177e-14 NA NA NA hsa-miR-338-3p PAPSS2 0.399637046793888 0.00344106432206527 -0.0031128578401276 0.96674770488158 miRanda -0.108734328769623 9.08275255772921e-06 NA NA NA hsa-miR-330-5p PARP11 0.262932095995619 0.0465226565966542 -0.0481893246985852 0.351320705311713 miRanda -0.104438826331939 6.02160992293725e-12 NA NA NA hsa-miR-490-3p PARP9 0.834268051506887 5.26203010743174e-06 -0.453419753951288 3.43925254593594e-08 miRanda -0.132646113560123 1.17605489627097e-12 NA NA NA hsa-miR-139-5p PARVG 0.647754756897662 2.1537830723695e-06 -0.319372992466024 0.0028307425414582 MirTarget -0.299933426244065 5.25906511530603e-19 NA NA NA hsa-miR-129-5p PATL2 0.567133990117154 0.00116152215679873 -0.0105049858440746 0.919415415860884 miRanda -0.119536437845807 5.40200737957903e-06 NA NA NA hsa-miR-139-5p PAX3 0.647754756897662 2.1537830723695e-06 -1.09465749978219 5.40279733529004e-07 miRanda -0.293283841871614 4.48974737761547e-05 NA NA NA hsa-miR-139-5p PBX3 0.647754756897662 2.1537830723695e-06 -0.288286583628169 0.000181956435695858 miRanda -0.185439000986379 1.6752338961676e-14 NA NA NA hsa-miR-330-5p PCDH15 0.262932095995619 0.0465226565966542 1.08545558536262 1.9411501152954e-08 miRanda -0.199908316345287 0.0017704149051273 NA NA NA hsa-miR-129-5p PCDH18 0.567133990117154 0.00116152215679873 -0.384702109514464 3.05492811513852e-06 miRanda -0.118549377474036 2.66415096004729e-09 NA NA NA hsa-miR-139-5p PCDH18 0.647754756897662 2.1537830723695e-06 -0.384702109514464 3.05492811513852e-06 miRanda -0.210771473839447 7.2267639174877e-17 NA NA NA hsa-miR-338-5p PCDH18 0.424003687569646 0.00246415720301228 -0.384702109514464 3.05492811513852e-06 mirMAP -0.154170763193119 3.25416295137925e-10 NA NA NA hsa-miR-485-3p PCDH18 0.530677478972608 0.00148549219838864 -0.384702109514464 3.05492811513852e-06 MirTarget -0.14344208040191 1.01468747978756e-12 NA NA NA hsa-miR-139-5p PCDHB7 0.647754756897662 2.1537830723695e-06 -0.574007024127923 1.94565630955229e-05 miRanda -0.107638268132546 0.0154551907923491 NA NA NA hsa-miR-129-5p PCDHB9 0.567133990117154 0.00116152215679873 -0.150902300534117 0.102758650167687 miRanda -0.134196036172724 1.95487932696606e-09 NA NA NA hsa-miR-338-5p PCNA 0.424003687569646 0.00246415720301228 -0.463982922014703 2.18911772156602e-14 PITA -0.105432694775061 5.63669972278373e-10 NA NA NA hsa-miR-490-3p PCNA 0.834268051506887 5.26203010743174e-06 -0.463982922014703 2.18911772156602e-14 miRanda -0.109348728305673 9.91122859029426e-18 NA NA NA hsa-miR-129-5p PCOLCE2 0.567133990117154 0.00116152215679873 -0.153534141721738 0.30358794689779 miRanda -0.110880749743917 0.00375113850852611 NA NA NA hsa-miR-139-5p PCSK5 0.647754756897662 2.1537830723695e-06 -0.305252774864113 0.00124254023281346 miRanda;miRNATAP -0.110203911277368 0.000409292854575986 NA NA NA hsa-miR-338-3p PCSK5 0.399637046793888 0.00344106432206527 -0.305252774864113 0.00124254023281346 miRanda -0.145248510246582 1.18085635779595e-05 NA NA NA hsa-miR-138-5p PDE3A 0.61608764992087 1.35200027885651e-05 0.241260329299709 0.0680836729875631 miRNATAP -0.135289379379272 0.000916778378804468 NA NA NA hsa-miR-338-3p PDE5A 0.399637046793888 0.00344106432206527 -0.294519056057045 0.000268285958057689 miRanda -0.152239828451 4.52927522542958e-08 NA NA NA hsa-miR-330-3p PDGFC 0.427388106938161 0.003004892844142 0.109641054681221 0.135071652654142 mirMAP -0.132885747489891 3.05218892289238e-11 NA NA NA hsa-miR-330-5p PDGFC 0.262932095995619 0.0465226565966542 0.109641054681221 0.135071652654142 miRanda -0.155809696055812 1.10163134717387e-12 NA NA NA hsa-miR-338-5p PDGFC 0.424003687569646 0.00246415720301228 0.109641054681221 0.135071652654142 PITA;mirMAP -0.10503757056074 6.27789583606703e-07 NA NA NA hsa-miR-330-5p PDGFRA 0.262932095995619 0.0465226565966542 0.214227835759105 0.123422750860141 miRanda -0.122999029913756 0.00489006932093651 NA NA NA hsa-miR-490-3p PDLIM1 0.834268051506887 5.26203010743174e-06 -0.912277052963635 1.19010566658757e-12 miRanda -0.17409183861203 2.25985805428502e-08 NA NA NA hsa-miR-138-5p PDPN 0.61608764992087 1.35200027885651e-05 -1.00574945169594 1.60350453569877e-07 MirTarget -0.251280056416012 2.8072610678822e-05 NA NA NA hsa-miR-330-5p PGF 0.262932095995619 0.0465226565966542 0.34118444659808 0.0219813356706474 mirMAP -0.125895430647764 0.0103349467838067 NA NA NA hsa-miR-139-5p PGGT1B 0.647754756897662 2.1537830723695e-06 -0.129370242377727 0.00158595400129882 PITA;miRanda -0.13201110991762 1.55999150641963e-36 NA NA NA hsa-miR-139-5p PGPEP1 0.647754756897662 2.1537830723695e-06 -0.151203784884549 0.00409261870145892 mirMAP -0.127825376913162 6.66210518228866e-22 NA NA NA hsa-miR-330-5p PHB2 0.262932095995619 0.0465226565966542 -0.00290048287686329 0.959990533876881 miRanda -0.118026152894526 3.11993586514477e-18 NA NA NA hsa-miR-330-5p PHF21A 0.262932095995619 0.0465226565966542 0.0808475917900529 0.123057895195032 mirMAP -0.110424179625923 7.48680048958886e-21 NA NA NA hsa-miR-485-3p PHF21B 0.530677478972608 0.00148549219838864 0.269994686278086 0.00102558803248362 PITA -0.117602710138476 6.32022254435566e-09 NA NA NA hsa-miR-129-5p PHLDA1 0.567133990117154 0.00116152215679873 -0.00612214187838589 0.954037491580001 miRanda;mirMAP -0.152862313979368 1.54929347373993e-10 NA NA NA hsa-miR-338-5p PHLDA1 0.424003687569646 0.00246415720301228 -0.00612214187838589 0.954037491580001 mirMAP -0.10206736774976 0.000633621545807533 NA NA NA hsa-miR-485-3p PHLDA1 0.530677478972608 0.00148549219838864 -0.00612214187838589 0.954037491580001 mirMAP -0.154787280207563 1.90884600932884e-10 NA NA NA hsa-miR-338-3p PHLDB3 0.399637046793888 0.00344106432206527 -0.149739791016642 0.0108001531970641 miRanda -0.112821350420792 1.02425030709745e-08 NA NA NA hsa-miR-129-5p PIF1 0.567133990117154 0.00116152215679873 -0.630579409415258 6.20260408489538e-07 miRanda -0.133340305240807 4.39113952460975e-05 NA NA NA hsa-miR-139-5p PIH1D2 0.647754756897662 2.1537830723695e-06 -0.18713857714594 0.00981591334527607 miRanda -0.150804401931471 1.60429762742289e-10 NA NA NA hsa-miR-139-5p PIK3AP1 0.647754756897662 2.1537830723695e-06 -0.25591582080965 0.00631029016387884 miRanda -0.240906416252318 2.66551359466428e-16 NA NA NA hsa-miR-139-5p PIK3CG 0.647754756897662 2.1537830723695e-06 -0.426342297358176 0.000910429107358144 miRanda -0.231442980598987 3.92120693342636e-08 NA NA NA hsa-miR-330-5p PILRB 0.262932095995619 0.0465226565966542 -0.107185928039089 0.231133334769779 miRanda -0.166328721250991 2.6726329207367e-09 NA NA NA hsa-miR-129-5p PITX1 0.567133990117154 0.00116152215679873 -1.04961796208943 1.80061166893988e-06 miRanda -0.343449558183139 8.18033300543738e-10 NA NA NA hsa-miR-425-3p PKN1 0.173302979693283 0.0801548384038341 -0.0531964429866321 0.393680266532639 miRNAWalker2_validate -0.159300210443682 3.23792325368591e-16 NA NA NA hsa-miR-139-5p PLA2G4A 0.647754756897662 2.1537830723695e-06 -0.459553101816426 3.9697996959269e-06 miRanda -0.196719913317323 1.19655643220759e-09 NA NA NA hsa-miR-338-3p PLAC8 0.399637046793888 0.00344106432206527 -1.30787076425333 3.21087837144629e-12 miRanda -0.288548226385564 1.69136020852516e-05 NA NA NA hsa-miR-139-5p PLAT 0.647754756897662 2.1537830723695e-06 -1.09210598038737 9.65791511314903e-17 miRanda -0.163294155461914 0.000230746726386513 NA NA NA hsa-miR-139-5p PLAUR 0.647754756897662 2.1537830723695e-06 -0.722626050671039 5.39188580921632e-11 miRanda -0.309559780840235 3.94032851245673e-18 NA NA NA hsa-miR-338-5p PLAUR 0.424003687569646 0.00246415720301228 -0.722626050671039 5.39188580921632e-11 MirTarget -0.124905324771726 0.00038146624989623 NA NA NA hsa-miR-139-5p PLBD1 0.647754756897662 2.1537830723695e-06 -0.664055932709367 4.59553486378304e-08 miRanda -0.325019722364945 1.92700620814305e-16 NA NA NA hsa-miR-138-5p PLD2 0.61608764992087 1.35200027885651e-05 -0.012178025243057 0.838496276273452 MirTarget -0.11260331070407 6.83689923086335e-13 NA NA NA hsa-miR-129-5p PLEK 0.567133990117154 0.00116152215679873 -0.302107358002529 0.00573315307325269 MirTarget -0.107438736182337 8.92760822382802e-05 NA NA NA hsa-miR-138-5p PLEK2 0.61608764992087 1.35200027885651e-05 -1.14950731519334 1.25610000852046e-13 miRNAWalker2_validate -0.212403842778221 1.39797005593219e-05 NA NA NA hsa-miR-330-3p PLEKHH2 0.427388106938161 0.003004892844142 -0.0584698629088356 0.603498655341388 miRNATAP -0.166296522633316 5.59221978672569e-07 NA NA NA hsa-miR-129-5p PLEKHH3 0.567133990117154 0.00116152215679873 -0.128426490105225 0.0214733417554944 PITA;miRanda -0.11632899079143 5.14097126086184e-22 NA NA NA hsa-miR-330-5p PLGLB2 0.262932095995619 0.0465226565966542 0.107534863639612 0.166014235836982 miRanda -0.116397326477425 5.52106551071375e-06 NA NA NA hsa-miR-129-5p PLSCR1 0.567133990117154 0.00116152215679873 -0.675930278874797 6.64715472602715e-13 miRanda -0.119675547372576 6.36228742623128e-07 NA NA NA hsa-miR-138-5p PLXNB2 0.61608764992087 1.35200027885651e-05 -0.132647321414402 0.0224282194893427 MirTarget;miRNATAP -0.124434716986312 6.24688996245766e-23 NA NA NA hsa-miR-129-5p PMP2 0.567133990117154 0.00116152215679873 -0.0604735913620686 0.624146339877256 MirTarget -0.139668726495721 6.74927600555069e-07 NA NA NA hsa-miR-129-5p POFUT1 0.567133990117154 0.00116152215679873 -0.220618429357918 1.89750966865648e-05 miRanda -0.100784914936921 7.80326283888545e-27 NA NA NA hsa-miR-490-3p POFUT1 0.834268051506887 5.26203010743174e-06 -0.220618429357918 1.89750966865648e-05 miRanda -0.105654112671427 7.10069226009996e-34 NA NA NA hsa-miR-138-5p POFUT2 0.61608764992087 1.35200027885651e-05 -0.0888309271662386 0.0704201719803718 mirMAP -0.105877080963887 3.99574176823053e-18 NA NA NA hsa-miR-330-5p POLR2F 0.262932095995619 0.0465226565966542 0.300744720512116 0.000369708541853824 miRanda;miRNATAP -0.181338895818825 1.43179535658329e-13 NA NA NA hsa-miR-139-5p POPDC2 0.647754756897662 2.1537830723695e-06 -0.132208414075783 0.0115419901040237 miRanda -0.116337007419036 6.55066707600318e-12 NA NA NA hsa-miR-139-5p POSTN 0.647754756897662 2.1537830723695e-06 -1.81363654682377 4.0599648403877e-09 miRanda -0.358023364097083 0.000515291068190898 NA NA NA hsa-miR-129-5p POTEF 0.567133990117154 0.00116152215679873 -0.403469696521693 0.000329400281736376 miRanda -0.176094392837108 5.50661609549922e-10 NA NA NA hsa-miR-139-5p POU3F2 0.647754756897662 2.1537830723695e-06 -0.16048972441429 0.0246346555752979 miRanda -0.157789190460076 1.67567159193011e-14 NA NA NA hsa-miR-338-5p POU3F2 0.424003687569646 0.00246415720301228 -0.16048972441429 0.0246346555752979 PITA;miRNATAP -0.105250706305579 1.36873343074332e-07 NA NA NA hsa-miR-338-5p POU5F1B 0.424003687569646 0.00246415720301228 -0.0450470013977253 0.633595233874879 mirMAP -0.105165726591324 0.000371425057212792 NA NA NA hsa-miR-139-5p PPIH 0.647754756897662 2.1537830723695e-06 -0.191956466694628 0.000212384297573484 miRanda -0.120324186446336 3.46797203517624e-15 NA NA NA hsa-miR-129-5p PPP1R3B 0.567133990117154 0.00116152215679873 -0.335294486111191 4.90341683418379e-05 MirTarget;miRanda -0.167389508561167 9.08993654082359e-17 NA NA NA hsa-miR-139-5p PPP1R3B 0.647754756897662 2.1537830723695e-06 -0.335294486111191 4.90341683418379e-05 miRanda -0.282690964451038 4.87873337257351e-29 NA NA NA hsa-miR-139-5p PQLC3 0.647754756897662 2.1537830723695e-06 -0.238728384082075 7.1247432164243e-05 miRanda -0.150891851815403 4.56528454286115e-15 NA NA NA hsa-miR-139-5p PRC1 0.647754756897662 2.1537830723695e-06 -0.832645181231761 1.14444380608961e-18 miRanda -0.104433797599763 0.000919616773293706 NA NA NA hsa-miR-139-5p PRDM1 0.647754756897662 2.1537830723695e-06 -0.325388961747828 1.23083637043488e-05 miRanda -0.143553533025216 1.47878867824787e-09 NA NA NA hsa-miR-330-3p PRIM2 0.427388106938161 0.003004892844142 -0.320792893850663 3.65908100960621e-12 MirTarget -0.120190893899089 1.26366108778574e-19 NA NA NA hsa-miR-330-5p PRIM2 0.262932095995619 0.0465226565966542 -0.320792893850663 3.65908100960621e-12 miRanda -0.12953551138969 6.47317658406394e-19 NA NA NA hsa-miR-338-3p PRIM2 0.399637046793888 0.00344106432206527 -0.320792893850663 3.65908100960621e-12 miRanda -0.149220470348235 2.35961798702715e-22 NA NA NA hsa-miR-138-1-3p PRKD1 0.446369405595197 0.000598407910928167 0.0225210494106518 0.692199432788483 MirTarget -0.125445587528211 1.01621214558989e-14 NA NA NA hsa-miR-139-5p PRKD1 0.647754756897662 2.1537830723695e-06 0.0225210494106518 0.692199432788483 miRanda -0.160725199383638 1.49783958942233e-25 NA NA NA hsa-miR-490-3p PRKD1 0.834268051506887 5.26203010743174e-06 0.0225210494106518 0.692199432788483 miRanda -0.101794218978989 3.67977785647533e-19 NA NA NA hsa-miR-139-5p PRKD3 0.647754756897662 2.1537830723695e-06 -0.100051052178488 0.071502271398845 MirTarget;miRanda;miRNATAP -0.125991964638085 2.57411983142334e-17 NA NA NA hsa-miR-139-5p PRKX 0.647754756897662 2.1537830723695e-06 0.234656702391645 0.00431000884646549 MirTarget -0.111049071581413 1.00400340749505e-05 NA NA NA hsa-miR-139-5p PROS1 0.647754756897662 2.1537830723695e-06 -0.471159806169387 1.03582105723755e-07 miRanda -0.227746820854414 7.93172971897755e-17 NA NA NA hsa-miR-139-5p PRPF38A 0.647754756897662 2.1537830723695e-06 -0.0148416970818275 0.780097087550291 miRanda -0.116231063910547 3.77710254295234e-19 NA NA NA hsa-miR-139-5p PRPF38B 0.647754756897662 2.1537830723695e-06 -0.156380399561996 0.00380124715096214 miRanda -0.122746660295038 3.29899995971016e-20 NA NA NA hsa-miR-139-5p PRR11 0.647754756897662 2.1537830723695e-06 -0.704853965885329 1.4579007898907e-07 miRanda -0.185188822105563 3.20200103589671e-05 NA NA NA hsa-miR-139-5p PRR15 0.647754756897662 2.1537830723695e-06 -0.334736023051831 0.0111369894490579 miRanda -0.195785099040394 5.80208380845834e-06 NA NA NA hsa-miR-139-5p PRRX1 0.647754756897662 2.1537830723695e-06 -0.141670792066549 0.106318883741695 miRanda -0.214286949760457 2.05743062163166e-17 NA NA NA hsa-miR-330-3p PRRX1 0.427388106938161 0.003004892844142 -0.141670792066549 0.106318883741695 PITA;miRNATAP -0.179192530460112 1.35046781985633e-14 NA NA NA hsa-miR-338-3p PRRX1 0.399637046793888 0.00344106432206527 -0.141670792066549 0.106318883741695 miRanda -0.138029551863811 5.28108486159439e-07 NA NA NA hsa-miR-485-3p PRRX1 0.530677478972608 0.00148549219838864 -0.141670792066549 0.106318883741695 PITA -0.168539813584856 2.77796325786087e-17 NA NA NA hsa-miR-330-5p PRSS27 0.262932095995619 0.0465226565966542 0.0317893451901208 0.648733573244978 miRanda -0.170340009325632 1.97510799839714e-14 NA NA NA hsa-miR-330-3p PRTG 0.427388106938161 0.003004892844142 0.243048238748139 0.00270556366215218 MirTarget;miRNATAP -0.145332792021769 3.942360516986e-10 NA NA NA hsa-miR-338-3p PRTG 0.399637046793888 0.00344106432206527 0.243048238748139 0.00270556366215218 miRanda -0.146743014078757 6.5693030110925e-08 NA NA NA hsa-miR-139-5p PSPH 0.647754756897662 2.1537830723695e-06 -0.135142700077082 0.0184021727575335 MirTarget;miRanda -0.114143772750584 5.92482201693712e-12 NA NA NA hsa-miR-129-5p PTBP1 0.567133990117154 0.00116152215679873 -0.327690884947516 5.58607946216013e-08 miRanda -0.153618832131901 2.98419209905178e-43 NA NA NA hsa-miR-330-5p PTBP1 0.262932095995619 0.0465226565966542 -0.327690884947516 5.58607946216013e-08 miRanda;miRNATAP -0.161378247161183 3.27298216057145e-27 NA NA NA hsa-miR-338-3p PTCH1 0.399637046793888 0.00344106432206527 0.132480074128631 0.192501865765185 miRanda -0.100850104451407 0.00233107367257767 NA NA NA hsa-miR-338-3p PTGER4 0.399637046793888 0.00344106432206527 -0.597897316793837 4.70207643022314e-07 miRanda -0.115906986660992 0.00597709225135327 NA NA NA hsa-miR-338-3p PTGIR 0.399637046793888 0.00344106432206527 -0.591800263125105 4.86692906716632e-09 miRanda -0.12705559396577 0.000380992600773718 NA NA NA hsa-miR-330-5p PTK7 0.262932095995619 0.0465226565966542 -0.224130042870586 0.000757250760151891 miRanda -0.164707777817596 2.76413873113431e-17 NA NA NA hsa-miR-338-3p PTK7 0.399637046793888 0.00344106432206527 -0.224130042870586 0.000757250760151891 miRanda -0.193715125678243 3.03306597266488e-21 NA NA NA hsa-miR-330-5p PTMS 0.262932095995619 0.0465226565966542 -0.216558693886007 0.00590635892555175 miRanda -0.109333112220968 1.23973260481573e-07 NA NA NA hsa-miR-139-5p PTPN13 0.647754756897662 2.1537830723695e-06 -0.145616852314151 0.0777628896676353 miRanda -0.117796364944909 1.62885929142994e-06 NA NA NA hsa-miR-139-5p PTPN18 0.647754756897662 2.1537830723695e-06 -0.189323134383252 0.000340853482278938 miRanda -0.104202009287893 2.70790810671948e-12 NA NA NA hsa-miR-139-5p PTPN2 0.647754756897662 2.1537830723695e-06 -0.174921966398655 8.20892693990839e-05 miRanda -0.109043753916358 2.97082150181987e-17 NA NA NA hsa-miR-129-5p PTPN22 0.567133990117154 0.00116152215679873 -1.03442974692202 1.65987628778479e-11 miRanda -0.183387566783039 3.56544856099379e-06 NA NA NA hsa-miR-330-5p PTPN7 0.262932095995619 0.0465226565966542 -1.11872757965125 3.0143142391229e-13 miRanda -0.129213204756746 0.0133491606178471 NA NA NA hsa-miR-338-3p PTPRG 0.399637046793888 0.00344106432206527 0.0853317352738525 0.247888570660255 MirTarget;miRanda -0.120300874201223 2.00912321465359e-07 NA NA NA hsa-miR-129-5p PTX3 0.567133990117154 0.00116152215679873 -0.949207819870183 5.94256337900885e-12 miRanda -0.184708357961068 2.50007087221503e-07 NA NA NA hsa-miR-139-5p PTX3 0.647754756897662 2.1537830723695e-06 -0.949207819870183 5.94256337900885e-12 miRanda -0.303744194667391 3.22261101717322e-11 NA NA NA hsa-miR-139-5p RAB27A 0.647754756897662 2.1537830723695e-06 -0.441222253888518 3.7756155293314e-10 miRanda -0.168858377116564 1.60368261431984e-13 NA NA NA hsa-miR-129-5p RAB32 0.567133990117154 0.00116152215679873 -0.490193276178291 1.04953485696632e-07 MirTarget -0.10870727792444 3.83358654255199e-06 NA NA NA hsa-miR-129-5p RAC2 0.567133990117154 0.00116152215679873 -0.543102090563633 6.32748728883053e-07 miRanda -0.163216019318866 3.88418743152648e-09 NA NA NA hsa-miR-490-3p RAD51 0.834268051506887 5.26203010743174e-06 -1.06005272126396 5.52919673000504e-19 miRanda -0.158623755092003 7.15996948534693e-08 NA NA NA hsa-miR-330-3p RAD52 0.427388106938161 0.003004892844142 0.0931087834852562 0.104824517834556 mirMAP -0.103613206821754 2.13401851208634e-10 NA NA NA hsa-miR-139-5p RAI14 0.647754756897662 2.1537830723695e-06 -0.276834679739968 1.41986991265918e-06 miRanda -0.122143811948372 1.64767893802675e-12 NA NA NA hsa-miR-330-5p RANBP17 0.262932095995619 0.0465226565966542 0.636951450886045 2.25080338194387e-05 miRanda -0.13497747501473 0.00714250124924326 NA NA NA hsa-miR-139-5p RAP1B 0.647754756897662 2.1537830723695e-06 -0.142944911590131 0.00328482194864843 miRanda;miRNATAP -0.121287779626316 5.14664639145908e-24 22642900 Regulation of RAP1B by miR 139 suppresses human colorectal carcinoma cell proliferation; Potential functions of miR-139 were evaluated in colorectal carcinoma cell lines SW480 SW620 LS174 T and HCT116 using miR-139 mimics anti-miR-139 and siRNA RAP1B; Mechanistic studies revealed that miR-139 repressed the activity of a reporter gene fused to the 3'-untranslated region of RAP1B whereas miR-139 silencing up-regulated the expression of the reporter gene; RNAi-mediated knockdown of RAP1B phenocopied the antiproliferative effect of miR-139 whereas the overexpression of RAP1B blocked miR-139-mediated antiproliferative effects in CRC cells; Taken together these results demonstrated that miR-139 decreases proliferation by directly targeting RAP1B defining miR-139 as a new putative tumour suppressor miRNA in CRC colorectal cancer hsa-miR-330-5p RASSF4 0.262932095995619 0.0465226565966542 0.333778602138675 0.000274001262427714 MirTarget;miRanda -0.132621019258588 4.22073290469624e-07 NA NA NA hsa-miR-138-5p RAVER1 0.61608764992087 1.35200027885651e-05 -0.20765642300109 0.000210008273604412 MirTarget -0.14326880920348 1.80492527389965e-28 NA NA NA hsa-miR-139-5p RB1 0.647754756897662 2.1537830723695e-06 -0.102426353692763 0.0803433627132396 miRanda -0.118561872957923 2.0386521698372e-14 NA NA NA hsa-miR-330-5p RBM10 0.262932095995619 0.0465226565966542 -0.0387305183014268 0.436518830621182 miRNATAP -0.107562156039326 1.46797970128323e-23 NA NA NA hsa-miR-490-3p RBM38 0.834268051506887 5.26203010743174e-06 -0.24061305079183 2.97262485889682e-05 miRanda -0.11600979603279 2.58806315179899e-23 NA NA NA hsa-miR-129-5p RBM47 0.567133990117154 0.00116152215679873 -0.438028276569881 0.000118616198125647 MirTarget;miRanda -0.189255073567681 3.61939366979557e-11 NA NA NA hsa-miR-485-3p RBM47 0.530677478972608 0.00148549219838864 -0.438028276569881 0.000118616198125647 miRNATAP -0.128488429451005 1.27071029897416e-05 NA NA NA hsa-miR-129-5p RBMS1 0.567133990117154 0.00116152215679873 -0.403837750010582 1.57669286426315e-07 MirTarget;PITA;miRanda;miRNATAP -0.113740638360947 1.86465561358181e-09 NA NA NA hsa-miR-139-5p RBMS1 0.647754756897662 2.1537830723695e-06 -0.403837750010582 1.57669286426315e-07 miRanda -0.222551562433162 9.14606115919715e-21 NA NA NA hsa-miR-338-3p RBMS3 0.399637046793888 0.00344106432206527 -0.0197419018770614 0.831944366485251 PITA;miRanda -0.144424434539939 8.91961754581371e-06 NA NA NA hsa-miR-139-5p RBPMS 0.647754756897662 2.1537830723695e-06 -0.27517323113725 0.00376623414638287 miRanda -0.152472380695799 7.81223479124506e-07 NA NA NA hsa-miR-330-5p RCC1 0.262932095995619 0.0465226565966542 -0.821565882580257 4.42705628381015e-08 miRanda -0.219088046571662 1.0863310672789e-05 NA NA NA hsa-miR-138-5p RELA 0.61608764992087 1.35200027885651e-05 -0.0739196932169728 0.126314845681894 miRNATAP -0.118615517312994 4.30114332551203e-37 NA NA NA hsa-miR-330-5p RELA 0.262932095995619 0.0465226565966542 -0.0739196932169728 0.126314845681894 miRanda -0.120880678711014 2.77817174522426e-33 NA NA NA hsa-miR-139-5p RELL1 0.647754756897662 2.1537830723695e-06 -0.36378050686361 3.11871270186005e-09 miRanda -0.196436246306088 2.40604841597637e-26 NA NA NA hsa-miR-338-3p REV3L 0.399637046793888 0.00344106432206527 -0.121609999036417 0.0738205804839239 miRanda -0.106713199277078 5.10345887051831e-07 NA NA NA hsa-miR-139-5p RFWD3 0.647754756897662 2.1537830723695e-06 -0.401670575738222 1.228091429319e-13 miRanda -0.139069590247926 1.49972691598143e-18 NA NA NA hsa-miR-139-5p RFX1 0.647754756897662 2.1537830723695e-06 -0.18470583934741 0.000121149908289893 miRanda -0.14037302050105 4.3264008998124e-25 NA NA NA hsa-miR-338-5p RFX1 0.424003687569646 0.00246415720301228 -0.18470583934741 0.000121149908289893 miRNATAP -0.102641980043811 1.05806551388933e-14 NA NA NA hsa-miR-139-5p RGMA 0.647754756897662 2.1537830723695e-06 0.174459793913817 0.0566162143316388 miRanda -0.130812658535878 4.08667423923378e-07 NA NA NA hsa-miR-330-3p RGMB 0.427388106938161 0.003004892844142 0.256302623208425 0.00597321033198123 mirMAP -0.105672800992634 4.22362004431396e-05 NA NA NA hsa-miR-129-5p RGS19 0.567133990117154 0.00116152215679873 -0.32333258741575 1.4992577809577e-06 miRanda;miRNATAP -0.102111607965594 3.92393713979809e-10 NA NA NA hsa-miR-138-5p RHOC 0.61608764992087 1.35200027885651e-05 -0.360474333884857 1.02894564375166e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.160452198953384 1.02289321769822e-13 24565984 We hypothesize that miR-138 can inhibit the function of RhoC and consequently the activation of downstream target molecules involve in the signaling cascade; Data obtained by G-LISA and real time PCR shows an inverse correlation between RhoC expression and miR-138 in HNSCC cell lines; Additionally we obtained a similar pattern of RhoC and miR-138 expression in primary tumors from HNSCC patients; Over expression of miR-138 in HNSCC lines showed down regulation of RhoC as well as a decrease in cell motility invasion colony and stress fiber formation; These findings strongly suggest that the inhibition of RhoC can be achieved by over expressing miR-138 which further attenuates the downstream signaling cascade leading to cancer progression and survival motility;progression;poor survival head and neck cancer hsa-miR-338-3p RHOH 0.399637046793888 0.00344106432206527 -0.517559463960349 1.63591927638498e-05 miRanda -0.103288303871634 0.0153851678942156 NA NA NA hsa-miR-485-3p RIN2 0.530677478972608 0.00148549219838864 0.240745375528584 0.000362345442071989 PITA -0.108274193494532 5.22138840100561e-14 NA NA NA hsa-miR-330-3p RIPK4 0.427388106938161 0.003004892844142 0.254671948482874 0.204775406839172 mirMAP -0.170586024533927 0.00509611240130446 NA NA NA hsa-miR-129-5p RIT1 0.567133990117154 0.00116152215679873 -0.188706860042853 6.97286772768684e-05 miRanda -0.109646839046384 2.6264927357451e-34 NA NA NA hsa-miR-139-5p RIT1 0.647754756897662 2.1537830723695e-06 -0.188706860042853 6.97286772768684e-05 miRanda -0.16922503244194 5.71865909842965e-52 NA NA NA hsa-miR-330-5p RIT1 0.262932095995619 0.0465226565966542 -0.188706860042853 6.97286772768684e-05 MirTarget;miRanda;miRNATAP -0.102042493482021 2.72292418515495e-17 NA NA NA hsa-miR-485-3p RIT1 0.530677478972608 0.00148549219838864 -0.188706860042853 6.97286772768684e-05 PITA -0.107087634057029 2.23209666230468e-31 NA NA NA hsa-miR-139-5p RMST 0.647754756897662 2.1537830723695e-06 0.0139568943035204 0.928695784466033 miRanda -0.189439668338073 5.2693679296867e-05 NA NA NA hsa-miR-129-5p RNASE6 0.567133990117154 0.00116152215679873 -0.332760261608957 0.00137317107121108 miRanda -0.103903740361066 7.43593677160448e-05 NA NA NA hsa-miR-330-5p RND2 0.262932095995619 0.0465226565966542 0.413994881767019 1.89318204342469e-05 miRanda -0.175456060303812 6.7551130728672e-10 NA NA NA hsa-miR-330-3p RND3 0.427388106938161 0.003004892844142 -0.212809450974607 0.0299863454014107 MirTarget;PITA -0.125363832291157 1.21590303862762e-05 NA NA NA hsa-miR-338-5p RND3 0.424003687569646 0.00246415720301228 -0.212809450974607 0.0299863454014107 MirTarget;PITA;miRNATAP -0.145546611850914 1.09646090253094e-06 NA NA NA hsa-miR-330-3p RNF180 0.427388106938161 0.003004892844142 0.189632414749556 0.00477599199581213 miRNATAP -0.118667785896154 3.64523798586101e-11 NA NA NA hsa-miR-338-5p RNF180 0.424003687569646 0.00246415720301228 0.189632414749556 0.00477599199581213 mirMAP;miRNATAP -0.135434002700624 3.81921370622097e-13 NA NA NA hsa-miR-338-3p RNFT1 0.399637046793888 0.00344106432206527 -0.237696380482987 2.06320676211124e-06 miRanda -0.124520506017475 2.56523374935312e-14 NA NA NA hsa-miR-139-5p ROCK1 0.647754756897662 2.1537830723695e-06 0.0158560281865459 0.80075947457625 PITA;miRanda -0.121585507119699 1.65803025551636e-12 20951699 The microRNA miR 139 suppresses metastasis and progression of hepatocellular carcinoma by down regulating Rho kinase 2 metastasis;progression liver cancer hsa-miR-138-5p RP2 0.61608764992087 1.35200027885651e-05 -0.151504636084979 0.0113013203152822 MirTarget -0.153954682248414 4.6557110741161e-21 NA NA NA hsa-miR-139-5p RP2 0.647754756897662 2.1537830723695e-06 -0.151504636084979 0.0113013203152822 miRanda -0.182994112053744 1.88459986565257e-26 NA NA NA hsa-miR-139-5p RPIA 0.647754756897662 2.1537830723695e-06 -0.246021382917435 4.04281533305641e-09 miRanda -0.118383344760403 3.55128835315249e-24 NA NA NA hsa-miR-330-3p RPL22L1 0.427388106938161 0.003004892844142 -0.0348598947866154 0.66797353713673 mirMAP -0.148616526303447 2.96800970684083e-10 NA NA NA hsa-miR-330-5p RPL34 0.262932095995619 0.0465226565966542 0.0924712278069242 0.211567108110164 miRanda -0.129808423458375 2.77527582647841e-11 NA NA NA hsa-miR-330-5p RPL4 0.262932095995619 0.0465226565966542 0.158228591822319 0.0563859395120774 miRNAWalker2_validate -0.142751028783997 1.79494992298829e-13 NA NA NA hsa-miR-129-5p RPLP0 0.567133990117154 0.00116152215679873 -0.0569639697966497 0.510538407102052 miRanda -0.129904412133477 7.26855881028368e-15 NA NA NA hsa-miR-330-3p RPS15A 0.427388106938161 0.003004892844142 -0.0991493575732454 0.18328882136163 mirMAP -0.140282424550151 5.21794014653536e-16 NA NA NA hsa-miR-338-3p RPS19 0.399637046793888 0.00344106432206527 -0.178101880815179 0.0311148065066869 miRanda -0.113319501178162 8.78058371090423e-07 NA NA NA hsa-miR-330-3p RPS2 0.427388106938161 0.003004892844142 -0.251680468619075 0.0013912019071249 miRNAWalker2_validate -0.148963887859166 1.97789767966828e-15 NA NA NA hsa-miR-129-5p RPS27L 0.567133990117154 0.00116152215679873 -0.140655596905614 0.0205285929945007 miRanda -0.117389960770592 1.53927709825511e-18 NA NA NA hsa-miR-330-3p RPS4X 0.427388106938161 0.003004892844142 0.0201143545358082 0.79095523516787 miRNAWalker2_validate -0.101747738139898 2.30661414896166e-10 NA NA NA hsa-miR-138-5p RPS6KA1 0.61608764992087 1.35200027885651e-05 -0.28845668158696 0.00241163224126914 MirTarget;miRNATAP -0.100557924867178 0.000472980824832504 NA NA NA hsa-miR-139-5p RPS6KA1 0.647754756897662 2.1537830723695e-06 -0.28845668158696 0.00241163224126914 miRanda -0.19069984741317 2.71535166303043e-10 NA NA NA hsa-miR-330-5p RPS7 0.262932095995619 0.0465226565966542 -0.0712218664253452 0.227453309399002 miRanda -0.100377535641733 1.49768107265026e-12 NA NA NA hsa-miR-330-5p RPS9 0.262932095995619 0.0465226565966542 -0.0310824043828095 0.67387928186778 miRanda -0.117971545088369 4.1211842102986e-11 NA NA NA hsa-miR-139-5p RREB1 0.647754756897662 2.1537830723695e-06 -0.0551871218009055 0.503506288965655 miRanda -0.191479226812593 1.13835925568376e-13 NA NA NA hsa-miR-330-5p RTKN2 0.262932095995619 0.0465226565966542 -0.643220635804703 2.2825377314092e-08 miRanda -0.12379822643772 0.00132368453945839 NA NA NA hsa-miR-338-5p RTKN2 0.424003687569646 0.00246415720301228 -0.643220635804703 2.2825377314092e-08 mirMAP -0.10070754710536 0.00610716637006038 NA NA NA hsa-miR-129-5p RUNX1 0.567133990117154 0.00116152215679873 -0.734921231104849 5.23748444198592e-09 PITA;miRanda;miRNATAP -0.148268478375939 4.13173619160848e-06 NA NA NA hsa-miR-139-5p RUNX1 0.647754756897662 2.1537830723695e-06 -0.734921231104849 5.23748444198592e-09 PITA;miRanda -0.36940679945308 4.76716883006541e-20 NA NA NA hsa-miR-338-3p RUNX1 0.399637046793888 0.00344106432206527 -0.734921231104849 5.23748444198592e-09 miRanda -0.195230622223689 1.04537583478384e-05 NA NA NA hsa-miR-338-5p RUNX1 0.424003687569646 0.00246415720301228 -0.734921231104849 5.23748444198592e-09 PITA;miRNATAP -0.127615992038155 0.00139255410421264 NA NA NA hsa-miR-139-5p RUNX2 0.647754756897662 2.1537830723695e-06 -0.271284599811931 0.00430204751703437 miRanda -0.187452457275213 1.37573076520574e-09 NA NA NA hsa-miR-129-5p RUNX3 0.567133990117154 0.00116152215679873 -0.790104494441175 1.05106973998558e-12 miRanda -0.19855604748873 3.05436658612535e-12 NA NA NA hsa-miR-139-5p RUNX3 0.647754756897662 2.1537830723695e-06 -0.790104494441175 1.05106973998558e-12 miRanda -0.387378788310108 1.01741579263182e-27 NA NA NA hsa-miR-330-3p RUNX3 0.427388106938161 0.003004892844142 -0.790104494441175 1.05106973998558e-12 PITA;miRNATAP -0.141400674674732 3.41560282647264e-05 NA NA NA hsa-miR-330-5p RUNX3 0.262932095995619 0.0465226565966542 -0.790104494441175 1.05106973998558e-12 MirTarget;miRanda;miRNATAP -0.115275179666015 0.00217263496379415 NA NA NA hsa-miR-338-5p RUNX3 0.424003687569646 0.00246415720301228 -0.790104494441175 1.05106973998558e-12 PITA;miRNATAP -0.175866021252776 7.3562208868378e-07 NA NA NA hsa-miR-129-5p S100A2 0.567133990117154 0.00116152215679873 -0.394696364077724 0.00184425931521286 miRanda -0.148839534550504 4.20080705822635e-06 NA NA NA hsa-miR-138-5p S100A2 0.61608764992087 1.35200027885651e-05 -0.394696364077724 0.00184425931521286 MirTarget -0.26037997610956 1.8185086775926e-11 NA NA NA hsa-miR-139-5p S100PBP 0.647754756897662 2.1537830723695e-06 -0.17111055674641 0.000723548087116715 miRanda -0.138984991215727 3.52245051296067e-25 NA NA NA hsa-miR-129-5p S1PR3 0.567133990117154 0.00116152215679873 -0.594738587829081 9.83124656400279e-07 MirTarget;miRanda -0.113532834733812 0.000229932475239176 NA NA NA hsa-miR-330-5p SAC3D1 0.262932095995619 0.0465226565966542 -0.127052978467693 0.0275095721502521 miRNATAP -0.101099924802492 2.49412201011802e-08 NA NA NA hsa-miR-139-5p SALL1 0.647754756897662 2.1537830723695e-06 -0.0789300407011639 0.359156021469349 miRanda -0.14602698130462 1.01221974578762e-08 NA NA NA hsa-miR-129-5p SAMD4A 0.567133990117154 0.00116152215679873 -0.101251010076747 0.20676302591627 miRanda;mirMAP -0.106369573899752 3.43880332928319e-08 NA NA NA hsa-miR-129-5p SAMD9 0.567133990117154 0.00116152215679873 -0.498895899565535 2.12978907773562e-07 miRanda -0.110959910352452 5.78034356583625e-06 NA NA NA hsa-miR-129-5p SAMD9L 0.567133990117154 0.00116152215679873 -0.471690135325048 1.06105446245868e-05 miRanda -0.100332110976721 0.000221562332641724 NA NA NA hsa-miR-139-5p SAMD9L 0.647754756897662 2.1537830723695e-06 -0.471690135325048 1.06105446245868e-05 miRanda -0.276732570403475 5.47607473919757e-16 NA NA NA hsa-miR-485-3p SAMHD1 0.530677478972608 0.00148549219838864 -0.254523671292922 0.00383170304629109 mirMAP -0.10753873143963 4.40383096115305e-07 NA NA NA hsa-miR-139-5p SAT1 0.647754756897662 2.1537830723695e-06 -0.255272986728388 0.000357264508817964 miRanda -0.103290938448159 1.51092330416243e-07 NA NA NA hsa-miR-330-5p SBK1 0.262932095995619 0.0465226565966542 0.0298859235973969 0.700316597808209 miRanda -0.121116317238913 1.54263870913977e-07 NA NA NA hsa-miR-129-5p SCIN 0.567133990117154 0.00116152215679873 -0.503989116620104 0.00391471358027477 miRanda -0.152701090046074 0.000603929329350704 NA NA NA hsa-miR-330-3p SCN3A 0.427388106938161 0.003004892844142 0.158370202280586 0.190987205289125 PITA;mirMAP -0.17421696615887 4.30350672973262e-07 NA NA NA hsa-miR-330-5p SCNM1 0.262932095995619 0.0465226565966542 -0.132383894120551 0.00654180142283936 miRanda;miRNATAP -0.107251932565458 2.47085633964614e-16 NA NA NA hsa-miR-129-5p SCUBE2 0.567133990117154 0.00116152215679873 -0.0540467047533042 0.645112699894905 miRNATAP -0.124341992645113 1.94782255411551e-05 NA NA NA hsa-miR-330-3p SDC1 0.427388106938161 0.003004892844142 -0.945050147298658 1.55209252921255e-15 mirMAP -0.107051798640283 0.00358833519215036 NA NA NA hsa-miR-338-3p SDC1 0.399637046793888 0.00344106432206527 -0.945050147298658 1.55209252921255e-15 miRanda -0.146394379524292 0.000609364752225489 NA NA NA hsa-miR-139-5p SDCCAG3 0.647754756897662 2.1537830723695e-06 -0.134431775864607 0.00935194600298073 miRanda -0.157373007316517 1.03670169733795e-30 NA NA NA hsa-miR-330-5p SDCCAG3 0.262932095995619 0.0465226565966542 -0.134431775864607 0.00935194600298073 miRanda -0.14965990548563 3.10278501528927e-27 NA NA NA hsa-miR-139-5p SEC24D 0.647754756897662 2.1537830723695e-06 -0.321064365651166 8.43214899725156e-06 miRanda -0.135713418436168 3.20743954151418e-09 NA NA NA hsa-miR-425-3p SEC31B 0.173302979693283 0.0801548384038341 0.367587723405905 0.000189664979243844 MirTarget -0.170263132892485 6.66682846041139e-05 NA NA NA hsa-miR-129-5p SEC61A1 0.567133990117154 0.00116152215679873 -0.266453861975053 5.82926997417209e-06 miRanda;miRNATAP -0.111390550547358 1.511720950681e-33 NA NA NA hsa-miR-490-3p SEC61A1 0.834268051506887 5.26203010743174e-06 -0.266453861975053 5.82926997417209e-06 miRanda -0.111619422455614 1.25245404685709e-38 NA NA NA hsa-miR-338-5p SELE 0.424003687569646 0.00246415720301228 -0.396623719685306 0.0703448351444783 miRNATAP -0.140356409801377 0.0438022730396476 NA NA NA hsa-miR-330-5p SEMA4G 0.262932095995619 0.0465226565966542 0.341232175062188 3.11154388333909e-07 miRanda -0.118106426813618 8.79227472469258e-09 NA NA NA hsa-miR-139-5p SERPINB1 0.647754756897662 2.1537830723695e-06 -0.314073971024728 0.000228461497027618 miRanda -0.118806016218437 1.71721588398848e-05 NA NA NA hsa-miR-129-5p SERPINE1 0.567133990117154 0.00116152215679873 -1.27620546981703 1.9162673271459e-12 miRanda -0.136388531449073 0.00376304958296275 NA NA NA hsa-miR-138-5p SERPINE1 0.61608764992087 1.35200027885651e-05 -1.27620546981703 1.9162673271459e-12 miRNAWalker2_validate -0.27183048471367 1.58790910020002e-06 NA NA NA hsa-miR-139-5p SERPINI2 0.647754756897662 2.1537830723695e-06 0.630400922467063 2.53322887442491e-05 miRanda -0.146178237657229 0.00327237004199819 NA NA NA hsa-miR-139-5p SF3A3 0.647754756897662 2.1537830723695e-06 -0.16744887150256 0.000965789925068611 PITA -0.104350227836233 3.14588642521329e-19 NA NA NA hsa-miR-129-5p SFRP4 0.567133990117154 0.00116152215679873 -0.837599072525795 4.88438094021333e-08 miRanda -0.175321879354888 9.76199357711033e-06 NA NA NA hsa-miR-138-5p SH3BP2 0.61608764992087 1.35200027885651e-05 -0.0151935322989249 0.835246771220392 mirMAP -0.139619832259279 2.62542234625888e-12 NA NA NA hsa-miR-138-5p SH3PXD2B 0.61608764992087 1.35200027885651e-05 -0.232442110520861 0.000432599553935746 mirMAP -0.120760461146284 1.34458659783046e-12 NA NA NA hsa-miR-129-5p SHOX2 0.567133990117154 0.00116152215679873 -1.87514280437733 8.19265939514181e-12 miRanda;miRNATAP -0.320018995492277 6.91030480764178e-06 NA NA NA hsa-miR-330-5p SIGLEC1 0.262932095995619 0.0465226565966542 -0.618986146287501 2.30263094252021e-05 mirMAP -0.179935728708862 0.00022075459825795 NA NA NA hsa-miR-139-5p SIGLEC11 0.647754756897662 2.1537830723695e-06 -0.100264366980032 0.403583032806799 miRanda -0.179305104963966 5.17790482873777e-06 NA NA NA hsa-miR-330-5p SIRT6 0.262932095995619 0.0465226565966542 -0.0506253527065814 0.299958577272858 miRanda -0.117408923810644 1.82796330480443e-16 NA NA NA hsa-miR-129-5p SIX1 0.567133990117154 0.00116152215679873 -0.818436777940132 2.85696266416685e-06 mirMAP -0.182484997380423 4.59506079829718e-05 NA NA NA hsa-miR-338-5p SIX1 0.424003687569646 0.00246415720301228 -0.818436777940132 2.85696266416685e-06 mirMAP -0.186324856831975 0.000765933389051936 NA NA NA hsa-miR-490-3p SIX1 0.834268051506887 5.26203010743174e-06 -0.818436777940132 2.85696266416685e-06 miRanda -0.217193321410361 2.18402392621879e-07 NA NA NA hsa-miR-139-5p SIX4 0.647754756897662 2.1537830723695e-06 -0.0402751420086522 0.685289321627619 miRanda -0.11095047521842 0.000588776707625155 NA NA NA hsa-miR-138-5p SIX5 0.61608764992087 1.35200027885651e-05 -0.184844151712891 0.0438990118844804 MirTarget -0.182676715965195 2.88245139891821e-11 NA NA NA hsa-miR-338-3p SIX5 0.399637046793888 0.00344106432206527 -0.184844151712891 0.0438990118844804 mirMAP -0.130363529321237 3.6112132250722e-05 NA NA NA hsa-miR-138-5p SKP2 0.61608764992087 1.35200027885651e-05 -0.304483103342994 2.39516717741556e-06 MirTarget -0.112767222560839 6.70974775053186e-09 NA NA NA hsa-miR-330-5p SLC12A4 0.262932095995619 0.0465226565966542 0.197110604709795 0.00283256353369226 mirMAP -0.11135650060088 1.97207467242797e-10 NA NA NA hsa-miR-139-5p SLC16A1 0.647754756897662 2.1537830723695e-06 -0.317322960099586 1.6853271016327e-06 miRanda -0.130394014195252 6.40313034198239e-14 NA NA NA hsa-miR-485-3p SLC16A9 0.530677478972608 0.00148549219838864 0.430420365667215 1.90601300363703e-07 MirTarget -0.121010930535678 6.38417922239205e-10 NA NA NA hsa-miR-330-5p SLC25A34 0.262932095995619 0.0465226565966542 0.0816497553107145 0.286665116088627 MirTarget;miRanda;miRNATAP -0.105386550110444 2.7365587098734e-05 NA NA NA hsa-miR-139-5p SLC25A43 0.647754756897662 2.1537830723695e-06 -0.349567545103757 0.00387609972150898 miRanda -0.178399510635555 7.083085658432e-06 NA NA NA hsa-miR-129-5p SLC26A2 0.567133990117154 0.00116152215679873 -0.565490422035814 4.48133784497618e-15 miRanda -0.117127865193406 3.694110616579e-11 NA NA NA hsa-miR-139-5p SLC26A2 0.647754756897662 2.1537830723695e-06 -0.565490422035814 4.48133784497618e-15 mirMAP -0.200848971011676 3.4038325119201e-19 NA NA NA hsa-miR-330-3p SLC26A2 0.427388106938161 0.003004892844142 -0.565490422035814 4.48133784497618e-15 mirMAP -0.10037424274359 2.00732525162488e-06 NA NA NA hsa-miR-338-5p SLC26A2 0.424003687569646 0.00246415720301228 -0.565490422035814 4.48133784497618e-15 mirMAP -0.119469040824105 5.51448268245505e-08 NA NA NA hsa-miR-129-5p SLC26A7 0.567133990117154 0.00116152215679873 -0.306238966898891 0.0159764339888317 miRanda -0.146925818795685 5.79770783660432e-06 NA NA NA hsa-miR-330-3p SLC26A7 0.427388106938161 0.003004892844142 -0.306238966898891 0.0159764339888317 mirMAP -0.168489402519471 1.08453601256948e-05 NA NA NA hsa-miR-338-3p SLC26A7 0.399637046793888 0.00344106432206527 -0.306238966898891 0.0159764339888317 miRanda -0.158552146299372 0.000391060642311184 NA NA NA hsa-miR-338-5p SLC26A7 0.424003687569646 0.00246415720301228 -0.306238966898891 0.0159764339888317 PITA;mirMAP -0.203204731994824 3.46555784985846e-07 NA NA NA hsa-miR-139-5p SLC35F2 0.647754756897662 2.1537830723695e-06 -0.0570895150829833 0.455066453272262 miRanda -0.111730840783787 3.49386865931067e-06 NA NA NA hsa-miR-139-5p SLC35F5 0.647754756897662 2.1537830723695e-06 -0.175836053243422 0.00130412894655374 miRanda -0.125820826700068 3.71924371164886e-15 NA NA NA hsa-miR-338-3p SLC35F5 0.399637046793888 0.00344106432206527 -0.175836053243422 0.00130412894655374 MirTarget;PITA;miRanda -0.115912729068367 1.57805154735971e-11 NA NA NA hsa-miR-139-5p SLC39A1 0.647754756897662 2.1537830723695e-06 -0.302166322577238 7.77613831500858e-08 miRanda -0.194113985913796 4.94703610293273e-48 NA NA NA hsa-miR-139-5p SLC39A7 0.647754756897662 2.1537830723695e-06 -0.169341877341379 0.000576647839051983 miRanda -0.115237304254982 3.45465083302002e-30 NA NA NA hsa-miR-129-5p SLC40A1 0.567133990117154 0.00116152215679873 -0.165189625766214 0.0471111364607047 miRanda -0.156895104426305 7.71131596127886e-16 NA NA NA hsa-miR-330-5p SLC40A1 0.262932095995619 0.0465226565966542 -0.165189625766214 0.0471111364607047 miRanda -0.127874760130378 6.68578534161047e-07 NA NA NA hsa-miR-338-5p SLC40A1 0.424003687569646 0.00246415720301228 -0.165189625766214 0.0471111364607047 PITA;mirMAP;miRNATAP -0.140966192238032 7.31793521720792e-09 NA NA NA hsa-miR-485-3p SLC40A1 0.530677478972608 0.00148549219838864 -0.165189625766214 0.0471111364607047 PITA -0.198171809511973 2.2873945344677e-24 NA NA NA hsa-miR-129-5p SLC43A3 0.567133990117154 0.00116152215679873 -0.843597146899545 1.42652643612355e-13 MirTarget -0.121377091347248 4.53487041144063e-05 NA NA NA hsa-miR-129-5p SLC47A2 0.567133990117154 0.00116152215679873 -0.942886444041 3.56604511435275e-05 miRanda -0.217344724309287 0.000213814486983224 NA NA NA hsa-miR-139-5p SLC4A7 0.647754756897662 2.1537830723695e-06 -0.356412791759793 1.40148461685098e-07 miRanda -0.14861305312851 6.81348633670651e-13 NA NA NA hsa-miR-330-3p SLC4A7 0.427388106938161 0.003004892844142 -0.356412791759793 1.40148461685098e-07 mirMAP -0.10032466035691 1.68601784447925e-07 NA NA NA hsa-miR-129-5p SLC5A9 0.567133990117154 0.00116152215679873 -0.288800799518468 0.0119956603242959 miRanda -0.110797923766569 0.00015928012899052 NA NA NA hsa-miR-338-3p SLC8A1 0.399637046793888 0.00344106432206527 0.145379589558613 0.0296956435410737 miRanda -0.100853721523323 1.08472539798309e-06 NA NA NA hsa-miR-330-5p SLC9A3 0.262932095995619 0.0465226565966542 0.107364862173598 0.331687046161423 MirTarget;miRanda -0.183092077808456 4.66920987663245e-07 NA NA NA hsa-miR-139-5p SLCO2B1 0.647754756897662 2.1537830723695e-06 -0.146215476224876 0.0641076301074497 miRanda -0.139229139959527 3.23976065979911e-10 NA NA NA hsa-miR-138-1-3p SLFN13 0.446369405595197 0.000598407910928167 -0.107350154488002 0.294186590401917 mirMAP -0.126776740376945 0.000260016534171115 NA NA NA hsa-miR-139-5p SMAD1 0.647754756897662 2.1537830723695e-06 -0.051829836077288 0.358976598674267 miRanda -0.127734900466985 5.29524445760858e-20 NA NA NA hsa-miR-338-3p SMAD5 0.399637046793888 0.00344106432206527 -0.034247200661774 0.521278878472159 miRanda -0.140685426598662 1.27214098303337e-25 NA NA NA hsa-miR-338-5p SMAD5 0.424003687569646 0.00246415720301228 -0.034247200661774 0.521278878472159 MirTarget;PITA;miRNATAP -0.102001429707341 1.08707224995568e-16 NA NA NA hsa-miR-129-5p SMC4 0.567133990117154 0.00116152215679873 -0.816976925644711 3.21723475956698e-22 miRanda -0.128440022245168 2.7535353821555e-09 NA NA NA hsa-miR-139-5p SMC4 0.647754756897662 2.1537830723695e-06 -0.816976925644711 3.21723475956698e-22 miRanda -0.235620226972883 6.69724970370657e-18 NA NA NA hsa-miR-338-3p SMC4 0.399637046793888 0.00344106432206527 -0.816976925644711 3.21723475956698e-22 miRanda -0.154655644438911 2.12526689929717e-07 NA NA NA hsa-miR-330-5p SMO 0.262932095995619 0.0465226565966542 -0.0780937069044523 0.311173931790624 MirTarget;miRanda -0.126373178460854 6.45659229965159e-08 NA NA NA hsa-miR-338-3p SMO 0.399637046793888 0.00344106432206527 -0.0780937069044523 0.311173931790624 miRNAWalker2_validate;miRTarBase;PITA;miRanda -0.175560038328041 8.14601889186587e-13 24824250;23599646;21671467 Smoothened SMO possible target of miR-338-3p mRNA and corresponding protein expression pattern were detected by semiquantitative RT-PCR and Western blotting; SMO might be a possible target of miR-338-3p which made it a potential antitumor candidate for treatment and prevention of CRC;Moreover the expression of miR-338-3p was determined by real-time reverse transcriptase polymerase chain reaction and Western blotting was used to detect the expression of the smoothened SMO the possible target of miR-338-3p protein in SW-620 cells; Furthermore overexpression of miR-338-3p inhibited the expression of SMO protein in SW-620 cells which showed obviously suppressed proliferation ability cellular proliferation inhibition rate CPIR 61.9% ± 5.2% vs 41.6% ± 4.8% P < 0.01; Moreover the downregulated expression of miR-338-3p caused upregulated expression of the SMO protein in SW-620 cells which showed significantly enhanced proliferation ability CPIR 19.2% ± 3.8% vs 41.6% ± 4.8% P < 0.01;Furthermore smoothened SMO was identified as a direct target of miR-338-3p; However small interfering RNA targeted SMO reversed the effects induced by blockade of miR-338-3p ;; colorectal cancer;colorectal cancer;liver cancer hsa-miR-490-3p SMO 0.834268051506887 5.26203010743174e-06 -0.0780937069044523 0.311173931790624 miRanda -0.100527531734678 2.7407329312488e-09 NA NA NA hsa-miR-330-5p SMOC1 0.262932095995619 0.0465226565966542 0.818319484344991 9.10793027339818e-07 miRanda -0.219438083376797 3.35902274959557e-05 NA NA NA hsa-miR-139-5p SNAPC1 0.647754756897662 2.1537830723695e-06 -0.11402024547504 0.0128607196335983 miRanda -0.138280242077352 3.97594926795292e-26 NA NA NA hsa-miR-338-5p SNCAIP 0.424003687569646 0.00246415720301228 0.225585159339637 0.0216985309939117 miRNATAP -0.131519070943915 8.30437697605629e-06 NA NA NA hsa-miR-330-5p SNRPA 0.262932095995619 0.0465226565966542 -0.128925316572125 0.014273921108797 PITA;miRanda;miRNATAP -0.106994255362776 6.66281858617202e-15 NA NA NA hsa-miR-139-5p SNRPB 0.647754756897662 2.1537830723695e-06 -0.315263340697111 6.90667006190069e-08 miRanda -0.126867161470135 1.18996618629128e-16 NA NA NA hsa-miR-139-5p SNTB1 0.647754756897662 2.1537830723695e-06 0.0554902268737338 0.532021669391912 miRanda -0.169007872561447 8.92787704744519e-10 NA NA NA hsa-miR-338-3p SNTB1 0.399637046793888 0.00344106432206527 0.0554902268737338 0.532021669391912 miRanda -0.121857029362125 4.09852602705756e-05 NA NA NA hsa-miR-138-5p SNX20 0.61608764992087 1.35200027885651e-05 -0.0188096130981563 0.853361162479147 MirTarget -0.16902471814797 5.84763689412306e-08 NA NA NA hsa-miR-490-3p SNX20 0.834268051506887 5.26203010743174e-06 -0.0188096130981563 0.853361162479147 miRanda -0.1200766852454 7.34690872303897e-07 NA NA NA hsa-miR-129-5p SOAT1 0.567133990117154 0.00116152215679873 -0.316268368237135 3.70028921411039e-07 miRanda;mirMAP -0.115469984206011 1.2142920471461e-15 NA NA NA hsa-miR-129-5p SOCS2 0.567133990117154 0.00116152215679873 -0.580576729364473 3.02551308203058e-07 miRanda -0.130394819125054 5.64073849270883e-06 NA NA NA hsa-miR-139-5p SOCS2 0.647754756897662 2.1537830723695e-06 -0.580576729364473 3.02551308203058e-07 PITA;miRanda;miRNATAP -0.271928867347072 8.08412662717116e-14 NA NA NA hsa-miR-330-5p SORBS3 0.262932095995619 0.0465226565966542 0.00823408401729253 0.893990738794729 miRanda -0.101757293877794 7.19225335836553e-11 NA NA NA hsa-miR-129-5p SOX11 0.567133990117154 0.00116152215679873 -0.269962225683294 0.0274165085032646 PITA;miRanda;mirMAP;miRNATAP -0.18432276735931 6.4950791627207e-10 NA NA NA hsa-miR-138-5p SOX11 0.61608764992087 1.35200027885651e-05 -0.269962225683294 0.0274165085032646 mirMAP -0.142534792030855 9.59090455827983e-05 NA NA NA hsa-miR-330-3p SOX11 0.427388106938161 0.003004892844142 -0.269962225683294 0.0274165085032646 PITA;mirMAP;miRNATAP -0.258449755051777 1.44971363960022e-13 NA NA NA hsa-miR-338-3p SOX11 0.399637046793888 0.00344106432206527 -0.269962225683294 0.0274165085032646 miRanda -0.204808008912517 6.95947045306179e-07 NA NA NA hsa-miR-338-5p SOX11 0.424003687569646 0.00246415720301228 -0.269962225683294 0.0274165085032646 PITA;mirMAP -0.169733736713909 4.77521070490902e-06 NA NA NA hsa-miR-425-3p SOX11 0.173302979693283 0.0801548384038341 -0.269962225683294 0.0274165085032646 mirMAP -0.285225947024144 4.68442415388497e-08 NA NA NA hsa-miR-485-3p SOX11 0.530677478972608 0.00148549219838864 -0.269962225683294 0.0274165085032646 PITA;miRNATAP -0.152555739753461 5.91291107065744e-07 NA NA NA hsa-miR-490-3p SOX11 0.834268051506887 5.26203010743174e-06 -0.269962225683294 0.0274165085032646 MirTarget;PITA;miRNATAP -0.155620094845449 3.26729532010901e-08 NA NA NA hsa-miR-330-5p SOX12 0.262932095995619 0.0465226565966542 -0.129091799823172 0.047221646929581 PITA;miRanda;mirMAP;miRNATAP -0.17521734222549 7.68753962186253e-23 NA NA NA hsa-miR-330-5p SOX13 0.262932095995619 0.0465226565966542 -0.0900980483581959 0.21189669092414 miRanda -0.106792609610653 5.98268566656921e-07 NA NA NA hsa-miR-129-5p SOX2 0.567133990117154 0.00116152215679873 -0.0616987319734541 0.499752069762618 MirTarget;PITA;miRanda;miRNATAP -0.138635015068037 1.21092964123688e-13 NA NA NA hsa-miR-139-5p SOX2 0.647754756897662 2.1537830723695e-06 -0.0616987319734541 0.499752069762618 miRanda -0.184095154087809 1.94463340909833e-14 NA NA NA hsa-miR-330-3p SOX21 0.427388106938161 0.003004892844142 0.0977556378089579 0.263408564652539 PITA;miRNATAP -0.160617489612358 2.24049327636152e-11 NA NA NA hsa-miR-129-5p SOX4 0.567133990117154 0.00116152215679873 -0.130399677516149 0.285587017757533 miRNAWalker2_validate;miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.123517646937467 1.74946704089023e-05 19487295;23677061 Using luciferase assays we documented a direct link between miR-129 and the two putative targets GALNT1 and SOX4;miR 129 2 suppresses proliferation and migration of esophageal carcinoma cells through downregulation of SOX4 expression ; bladder cancer;esophageal cancer hsa-miR-138-5p SOX4 0.61608764992087 1.35200027885651e-05 -0.130399677516149 0.285587017757533 miRNAWalker2_validate;MirTarget;miRNATAP -0.176228798042081 3.86797942730557e-07 23389731 Results indicated that miR-138 directly targeted SRY-related high mobility group box 4 SOX4 and hypoxia-inducible factor-1α HIF-1α and overexpression of SOX4 and HIF-1α effectively reversed the miR-138-mediated suppression of cell invasion; Analysis of human ovarian tumors further revealed downregulation of miR-138 and upregulation of SOX4 in late-stage tumors; Our study demonstrates the role and clinical relevance of miR-138 in ovarian cancer cell invasion and metastasis providing a potential therapeutic strategy for suppression of ovarian cancer metastasis by targeting SOX4 and HIF-1α pathways staging;metastasis ovarian cancer hsa-miR-338-3p SOX4 0.399637046793888 0.00344106432206527 -0.130399677516149 0.285587017757533 miRNATAP -0.197863726932147 5.12721534099703e-07 26252944;27508100;27186391 MicroRNA 338 3p functions as tumor suppressor in breast cancer by targeting SOX4;Erratum: MicroRNA 338 3p suppresses metastasis of lung cancer cells by targeting the EMT regulator Sox4;MicroRNA 338 3p suppresses metastasis of lung cancer cells by targeting the EMT regulator Sox4; Further studies indicated that the EMT-related transcription factor Sox4 was one direct target gene of miR-338-3p evidenced by the direct binding of miR-338-3p with the 3'untranslated region 3'UTR of Sox4; Furthermore miR-338-3p could decrease the expression of Sox4 both at mRNA and protein levels; Additionally over-expressing or silencing Sox4 could elevate or inhibit the migration and invasion of lung cancer cells parallel to the effect of miR-338-3p on the lung cancer cells; Meanwhile knockdown of Sox4 reversed the enhanced migration and invasion mediated by miR-338-3p; These results indicated that miR-338-3p suppressed the migration and invasion of NSCLC cells through targeting Sox4 involving in the EMT process ;metastasis;metastasis breast cancer;lung cancer;lung cancer hsa-miR-490-3p SOX4 0.834268051506887 5.26203010743174e-06 -0.130399677516149 0.285587017757533 miRanda -0.125989765673664 3.07754045050692e-06 NA NA NA hsa-miR-330-3p SOX6 0.427388106938161 0.003004892844142 0.128649486739933 0.179859567069835 MirTarget;miRNATAP -0.192893786878007 6.64695365022769e-14 NA NA NA hsa-miR-338-3p SOX6 0.399637046793888 0.00344106432206527 0.128649486739933 0.179859567069835 MirTarget;miRNATAP -0.134036358870088 1.09328204185703e-05 NA NA NA hsa-miR-129-5p SP100 0.567133990117154 0.00116152215679873 -0.560157610625066 2.21128846285936e-09 MirTarget;PITA;miRanda -0.106173671924088 7.09127375312945e-06 NA NA NA hsa-miR-338-3p SP3 0.399637046793888 0.00344106432206527 -0.0739382110011917 0.118541463892982 miRanda -0.102177704074907 3.00525170134418e-20 NA NA NA hsa-miR-338-3p SP6 0.399637046793888 0.00344106432206527 -0.514825896491236 4.4725151909351e-09 PITA;miRNATAP -0.153331564483077 8.07882037942805e-07 NA NA NA hsa-miR-139-5p SPAG1 0.647754756897662 2.1537830723695e-06 -0.123607584197437 0.17745196588383 miRanda -0.17131011052719 6.96943982723872e-09 NA NA NA hsa-miR-139-5p SPATA17 0.647754756897662 2.1537830723695e-06 -0.691678667608419 1.1223726128004e-07 miRanda -0.300198422040872 1.99900555202985e-12 NA NA NA hsa-miR-485-3p SPATA17 0.530677478972608 0.00148549219838864 -0.691678667608419 1.1223726128004e-07 mirMAP -0.115649125341354 0.000748915780745943 NA NA NA hsa-miR-139-5p SPATA5 0.647754756897662 2.1537830723695e-06 -0.156135134201154 0.000259206912367225 MirTarget;miRanda -0.132765416474591 4.31132134208826e-28 NA NA NA hsa-miR-490-3p SPDYA 0.834268051506887 5.26203010743174e-06 -0.017172523790901 0.829117987799969 miRanda -0.129083574850534 5.81089458482236e-12 NA NA NA hsa-miR-129-5p SPN 0.567133990117154 0.00116152215679873 -0.391372008456832 0.000280443010993604 mirMAP -0.110365611631716 6.56311696277476e-05 NA NA NA hsa-miR-138-5p SPN 0.61608764992087 1.35200027885651e-05 -0.391372008456832 0.000280443010993604 mirMAP -0.200940450248522 1.37796682612817e-09 NA NA NA hsa-miR-139-5p SPN 0.647754756897662 2.1537830723695e-06 -0.391372008456832 0.000280443010993604 mirMAP -0.286968101773734 1.52700250257918e-16 NA NA NA hsa-miR-490-3p SPN 0.834268051506887 5.26203010743174e-06 -0.391372008456832 0.000280443010993604 mirMAP -0.104765562177175 5.58375908945749e-05 NA NA NA hsa-miR-139-5p SPP1 0.647754756897662 2.1537830723695e-06 -0.447976109877681 0.0044066677157268 miRanda -0.244822467822024 1.08036600087553e-06 NA NA NA hsa-miR-129-5p SPRY1 0.567133990117154 0.00116152215679873 -0.744859554143746 7.13743723656347e-13 miRanda -0.106587967372138 6.86058035626931e-05 NA NA NA hsa-miR-338-5p SPRY1 0.424003687569646 0.00246415720301228 -0.744859554143746 7.13743723656347e-13 miRNATAP -0.12092997444351 0.000254865841611131 NA NA NA hsa-miR-138-5p SRGAP1 0.61608764992087 1.35200027885651e-05 -0.20363001724538 0.00127045832139932 mirMAP -0.124954489829075 4.17044105914372e-14 NA NA NA hsa-miR-139-5p SRGAP1 0.647754756897662 2.1537830723695e-06 -0.20363001724538 0.00127045832139932 miRanda -0.143513598048015 2.47194151099084e-16 NA NA NA hsa-miR-330-3p SRGAP1 0.427388106938161 0.003004892844142 -0.20363001724538 0.00127045832139932 mirMAP -0.101258997821791 4.76006973338464e-10 NA NA NA hsa-miR-129-5p SRPX 0.567133990117154 0.00116152215679873 0.177647964255849 0.158491102747183 miRanda -0.143238507265019 3.87681561523569e-06 NA NA NA hsa-miR-338-3p SRPX 0.399637046793888 0.00344106432206527 0.177647964255849 0.158491102747183 miRanda -0.119701786998691 0.00527570851010327 NA NA NA hsa-miR-330-3p SSTR5 0.427388106938161 0.003004892844142 0.691078123823692 4.59658583602678e-05 mirMAP -0.196457298497511 0.000132245435894152 NA NA NA hsa-miR-139-5p ST7L 0.647754756897662 2.1537830723695e-06 -0.141965873017202 0.000589412334174827 miRanda -0.102811295794483 5.89144091624465e-20 NA NA NA hsa-miR-330-3p ST8SIA2 0.427388106938161 0.003004892844142 0.657399124785801 0.000565147949616977 mirMAP -0.122178944923046 0.0348845917323899 NA NA NA hsa-miR-129-5p STC1 0.567133990117154 0.00116152215679873 -0.858686411368285 1.89142379770546e-06 miRanda -0.209054881811328 6.40171756610871e-06 NA NA NA hsa-miR-139-5p STC1 0.647754756897662 2.1537830723695e-06 -0.858686411368285 1.89142379770546e-06 miRanda -0.261587292711003 1.19087218367402e-05 NA NA NA hsa-miR-485-3p STC1 0.530677478972608 0.00148549219838864 -0.858686411368285 1.89142379770546e-06 PITA -0.105507222502069 0.0262832755246728 NA NA NA hsa-miR-129-5p STC2 0.567133990117154 0.00116152215679873 0.172622158555498 0.258206212246008 mirMAP -0.154959321381349 6.22852413948259e-05 NA NA NA hsa-miR-330-5p STC2 0.262932095995619 0.0465226565966542 0.172622158555498 0.258206212246008 miRanda -0.23313193878335 3.19081146109005e-06 NA NA NA hsa-miR-490-3p STEAP3 0.834268051506887 5.26203010743174e-06 -0.85150545110027 5.28142587331439e-10 miRanda -0.137561425956177 4.05745773296894e-05 NA NA NA hsa-miR-139-5p STIL 0.647754756897662 2.1537830723695e-06 -0.699014408249509 7.76497401235193e-16 miRanda -0.174736156193456 1.44233377751941e-09 NA NA NA hsa-miR-330-5p STK11 0.262932095995619 0.0465226565966542 -0.0323033339042791 0.501366117615317 miRanda -0.102574389360944 2.58965697812856e-19 NA NA NA hsa-miR-490-3p STK17A 0.834268051506887 5.26203010743174e-06 -0.346957735440176 2.62527011921946e-08 miRanda -0.11930190851365 5.45120900146464e-19 NA NA NA hsa-miR-338-5p STK17B 0.424003687569646 0.00246415720301228 0.226615205444522 0.0135271023421431 PITA;miRNATAP -0.130645396644179 1.07068322759176e-06 NA NA NA hsa-miR-129-5p STK32B 0.567133990117154 0.00116152215679873 -0.355120370318556 0.00722981509393973 miRanda -0.129001797713622 0.000127591967802183 NA NA NA hsa-miR-490-3p STK33 0.834268051506887 5.26203010743174e-06 -0.057166664595913 0.435007991438152 miRanda -0.1097885114932 1.65487908175707e-11 NA NA NA hsa-miR-138-5p STK40 0.61608764992087 1.35200027885651e-05 -0.425259479771283 5.47212717835944e-10 mirMAP -0.116364289774095 9.57489204048645e-10 NA NA NA hsa-miR-129-5p STON1 0.567133990117154 0.00116152215679873 0.225897485291743 0.0488545885577484 miRanda -0.170501730407851 1.16731384916932e-09 NA NA NA hsa-miR-139-5p STON1 0.647754756897662 2.1537830723695e-06 0.225897485291743 0.0488545885577484 miRanda -0.295075036298313 1.09315467179647e-16 NA NA NA hsa-miR-490-3p STON1 0.834268051506887 5.26203010743174e-06 0.225897485291743 0.0488545885577484 miRanda -0.165224414991719 3.45138204376854e-10 NA NA NA hsa-miR-490-3p STX11 0.834268051506887 5.26203010743174e-06 -0.346976918346305 0.000795699847479807 miRanda -0.114514130631035 3.81127510218119e-06 NA NA NA hsa-miR-139-5p STXBP4 0.647754756897662 2.1537830723695e-06 -0.139874813494677 0.0112235511445363 miRanda -0.151601938706718 1.51740601310396e-19 NA NA NA hsa-miR-338-5p STXBP4 0.424003687569646 0.00246415720301228 -0.139874813494677 0.0112235511445363 mirMAP -0.103435726590013 2.59851836145237e-10 NA NA NA hsa-miR-330-3p SULF2 0.427388106938161 0.003004892844142 0.379332718887802 0.000173223007058417 PITA;miRNATAP -0.157958163939155 4.1139718243969e-09 NA NA NA hsa-miR-330-5p SYN2 0.262932095995619 0.0465226565966542 0.0412320365636183 0.710941606049954 miRanda -0.127512072167297 0.000153788037967063 NA NA NA hsa-miR-330-3p SYNE2 0.427388106938161 0.003004892844142 -0.0954080030680862 0.21531640148532 PITA -0.125133193603012 1.9995409490701e-09 NA NA NA hsa-miR-330-5p SYNE2 0.262932095995619 0.0465226565966542 -0.0954080030680862 0.21531640148532 miRanda -0.127379174394962 2.900810162042e-08 NA NA NA hsa-miR-330-5p SYNPO2L 0.262932095995619 0.0465226565966542 0.146677490054494 0.234008939572551 MirTarget;miRNATAP -0.125118378817527 0.00221245035851238 NA NA NA hsa-miR-490-3p SYTL3 0.834268051506887 5.26203010743174e-06 -0.45528452739378 7.85494815285261e-07 miRanda -0.11360188751724 3.73920660955043e-07 NA NA NA hsa-miR-330-5p SYTL4 0.262932095995619 0.0465226565966542 0.502671665669641 2.98351968989543e-05 miRanda -0.173316128216462 4.8261932353857e-06 NA NA NA hsa-miR-338-3p SYTL4 0.399637046793888 0.00344106432206527 0.502671665669641 2.98351968989543e-05 MirTarget;miRanda -0.113282963806266 0.00507973083497274 NA NA NA hsa-miR-330-5p TAF1C 0.262932095995619 0.0465226565966542 0.111947658254498 0.0826380096708851 miRanda -0.150841393619772 1.34315061715401e-16 NA NA NA hsa-miR-129-5p TANC1 0.567133990117154 0.00116152215679873 -0.28847742384092 9.16120269084615e-06 miRanda -0.127044099218218 9.81021967495439e-20 NA NA NA hsa-miR-338-3p TANC1 0.399637046793888 0.00344106432206527 -0.28847742384092 9.16120269084615e-06 PITA;miRanda;miRNATAP -0.104754714768428 1.05816896612449e-07 NA NA NA hsa-miR-338-3p TAP1 0.399637046793888 0.00344106432206527 -0.408241270205663 1.74110072653164e-07 miRanda -0.135613096598643 7.13030586002434e-08 NA NA NA hsa-miR-139-5p TAP2 0.647754756897662 2.1537830723695e-06 -0.226435594973986 0.000115090558460245 miRanda -0.120175742487488 1.50418069992679e-13 NA NA NA hsa-miR-139-5p TAPBP 0.647754756897662 2.1537830723695e-06 -0.124471090286533 0.0257027285983073 miRanda -0.106261738762818 2.57990055932112e-15 NA NA NA hsa-miR-139-5p TBX1 0.647754756897662 2.1537830723695e-06 -0.474558857132024 0.00126823351480866 MirTarget;miRanda;miRNATAP -0.123335014291236 0.0111354181455231 NA NA NA hsa-miR-485-3p TBX15 0.530677478972608 0.00148549219838864 -0.560469009157826 4.25598732998202e-06 MirTarget;PITA;miRNATAP -0.126927268866142 6.99620005372506e-05 NA NA NA hsa-miR-330-5p TBX2 0.262932095995619 0.0465226565966542 -0.280425281875781 0.00236523336449854 miRanda;miRNATAP -0.207625500141239 1.44474090310618e-12 NA NA NA hsa-miR-338-3p TBX2 0.399637046793888 0.00344106432206527 -0.280425281875781 0.00236523336449854 miRanda -0.156845747756864 6.17219925957762e-07 NA NA NA hsa-miR-338-5p TBX2 0.424003687569646 0.00246415720301228 -0.280425281875781 0.00236523336449854 PITA;miRNATAP -0.15019116917806 9.90117422240437e-08 NA NA NA hsa-miR-129-5p TBXAS1 0.567133990117154 0.00116152215679873 -0.19075463192758 0.0690877638953055 miRanda -0.100219524875172 0.000125099104389367 NA NA NA hsa-miR-330-5p TCAP 0.262932095995619 0.0465226565966542 0.18004786654955 0.024272166169139 PITA;miRanda -0.168534512940219 9.3640309815575e-11 NA NA NA hsa-miR-129-5p TCF12 0.567133990117154 0.00116152215679873 0.0846606700441832 0.395208781788766 miRanda -0.107966809301207 6.33814712155452e-07 NA NA NA hsa-miR-139-5p TCF12 0.647754756897662 2.1537830723695e-06 0.0846606700441832 0.395208781788766 MirTarget;PITA;miRanda;miRNATAP -0.114082687061418 4.74476598648645e-05 NA NA NA hsa-miR-330-3p TCF12 0.427388106938161 0.003004892844142 0.0846606700441832 0.395208781788766 mirMAP;miRNATAP -0.191805164830222 2.74739126538964e-14 NA NA NA hsa-miR-330-5p TCF12 0.262932095995619 0.0465226565966542 0.0846606700441832 0.395208781788766 miRanda -0.233893047830977 1.74807459803842e-17 NA NA NA hsa-miR-338-5p TCF12 0.424003687569646 0.00246415720301228 0.0846606700441832 0.395208781788766 miRNATAP -0.10520394368684 8.97635656358387e-05 NA NA NA hsa-miR-129-5p TCF19 0.567133990117154 0.00116152215679873 -0.674256040162272 1.25114544436881e-18 miRanda -0.122100500651803 4.9196091500562e-10 NA NA NA hsa-miR-139-5p TCF19 0.647754756897662 2.1537830723695e-06 -0.674256040162272 1.25114544436881e-18 miRanda -0.212114513096958 1.57334324030855e-17 NA NA NA hsa-miR-330-5p TCF19 0.262932095995619 0.0465226565966542 -0.674256040162272 1.25114544436881e-18 miRanda -0.110768333490089 1.62093395961836e-05 NA NA NA hsa-miR-139-5p TCF3 0.647754756897662 2.1537830723695e-06 -0.169266059204923 0.0112915303563002 PITA;miRanda -0.187725193194739 2.56953311255443e-28 NA NA NA hsa-miR-338-3p TCF3 0.399637046793888 0.00344106432206527 -0.169266059204923 0.0112915303563002 mirMAP -0.17070487272598 2.18176229178526e-20 NA NA NA hsa-miR-129-5p TCF7L1 0.567133990117154 0.00116152215679873 -0.0471428239639211 0.548536470142966 miRanda -0.103152195739639 1.31187865675028e-08 NA NA NA hsa-miR-330-5p TCF7L1 0.262932095995619 0.0465226565966542 -0.0471428239639211 0.548536470142966 miRanda -0.230652687470906 4.06495126751103e-24 NA NA NA hsa-miR-338-3p TCTN1 0.399637046793888 0.00344106432206527 -0.162361568420708 0.00488344956364502 miRanda -0.102083083288198 2.05897278951279e-08 NA NA NA hsa-miR-138-5p TEAD1 0.61608764992087 1.35200027885651e-05 0.00514554964397007 0.94008046165122 MirTarget -0.115112209225569 1.50230673879044e-11 NA NA NA hsa-miR-139-5p TEAD1 0.647754756897662 2.1537830723695e-06 0.00514554964397007 0.94008046165122 mirMAP -0.100202803098473 4.21281094936729e-08 NA NA NA hsa-miR-330-3p TEAD1 0.427388106938161 0.003004892844142 0.00514554964397007 0.94008046165122 MirTarget;PITA;miRNATAP -0.103972398891782 4.59995953393487e-10 NA NA NA hsa-miR-338-3p TEAD4 0.399637046793888 0.00344106432206527 -0.889290550601129 2.48299933700711e-11 miRanda -0.193177472889211 5.06395726951048e-05 NA NA NA hsa-miR-129-5p TES 0.567133990117154 0.00116152215679873 -0.58510099642942 5.03044234501232e-12 miRanda -0.103614622254562 2.03497584758022e-06 NA NA NA hsa-miR-139-5p TES 0.647754756897662 2.1537830723695e-06 -0.58510099642942 5.03044234501232e-12 miRanda -0.198402801375707 8.44402905709154e-13 NA NA NA hsa-miR-338-3p TET1 0.399637046793888 0.00344106432206527 0.32640694280032 0.000352680131894381 miRanda -0.118940799729431 0.000173699121649772 NA NA NA hsa-miR-138-5p TET2 0.61608764992087 1.35200027885651e-05 0.116190829615161 0.0502346539924286 miRNATAP -0.100026980181547 1.4603090478491e-10 NA NA NA hsa-miR-330-5p TET2 0.262932095995619 0.0465226565966542 0.116190829615161 0.0502346539924286 miRanda -0.105989717203493 2.25602960467758e-10 NA NA NA hsa-miR-330-5p TFAP2A 0.262932095995619 0.0465226565966542 -0.685884234270908 2.15133075563627e-05 miRanda -0.219106144427862 4.56410228701671e-05 NA NA NA hsa-miR-338-5p TFAP2A 0.424003687569646 0.00246415720301228 -0.685884234270908 2.15133075563627e-05 PITA -0.18499770031084 0.000303492756641384 NA NA NA hsa-miR-330-3p TFAP2B 0.427388106938161 0.003004892844142 -1.1915484842482 8.65191495617553e-08 PITA;miRNATAP -0.154781294508189 0.0218315185645491 NA NA NA hsa-miR-330-5p TFAP2E 0.262932095995619 0.0465226565966542 0.357466153725786 0.00023923972103367 miRanda -0.112178120835137 0.000487046709018809 NA NA NA hsa-miR-330-5p TFAP4 0.262932095995619 0.0465226565966542 0.0609836647032878 0.325013845980431 MirTarget;miRanda -0.150039906678543 1.41882706349216e-15 NA NA NA hsa-miR-129-5p TFEC 0.567133990117154 0.00116152215679873 -0.303282982967835 0.00636393127908204 miRanda;mirMAP -0.139858434188737 6.98979278846892e-07 NA NA NA hsa-miR-139-5p TFEC 0.647754756897662 2.1537830723695e-06 -0.303282982967835 0.00636393127908204 PITA;miRanda -0.290411675240895 3.52404253858262e-16 NA NA NA hsa-miR-139-5p TGDS 0.647754756897662 2.1537830723695e-06 -0.105137158840501 0.0166190615152397 miRanda -0.11536755950311 3.85334815926691e-19 NA NA NA hsa-miR-139-5p TGFB1 0.647754756897662 2.1537830723695e-06 -0.188661409906794 0.0283645098828292 miRanda -0.257914873895623 5.01185822136258e-24 NA NA NA hsa-miR-490-3p TGFBR1 0.834268051506887 5.26203010743174e-06 -0.339248208669638 4.04767020935411e-07 PITA;miRanda;miRNATAP -0.116809003131924 7.17389189955076e-17 NA NA NA hsa-miR-129-5p TGIF1 0.567133990117154 0.00116152215679873 -0.665380756377461 7.44173206149791e-12 miRanda -0.150219840237625 8.20706392324882e-10 NA NA NA hsa-miR-139-5p TGIF1 0.647754756897662 2.1537830723695e-06 -0.665380756377461 7.44173206149791e-12 MirTarget;miRanda;miRNATAP -0.35693109602811 1.52184333585361e-32 NA NA NA hsa-miR-139-5p TGIF2 0.647754756897662 2.1537830723695e-06 -0.184066955610489 0.0180848085409582 miRanda -0.194600647049265 5.04771209279151e-16 NA NA NA hsa-miR-139-5p THBD 0.647754756897662 2.1537830723695e-06 -0.622675303326236 5.0384443468638e-07 miRanda -0.109715093454651 0.00757971483862444 NA NA NA hsa-miR-338-3p THBS1 0.399637046793888 0.00344106432206527 -0.542687032308895 0.00086983580017777 MirTarget;PITA;miRanda -0.218145983536744 0.000122986602033708 NA NA NA hsa-miR-330-5p THBS3 0.262932095995619 0.0465226565966542 -0.344232751428619 4.84163238987695e-08 PITA;miRNATAP -0.124727656240419 3.61411008576065e-10 NA NA NA hsa-miR-338-3p THSD7A 0.399637046793888 0.00344106432206527 5.78441863039458e-05 0.999640280838181 PITA;miRanda -0.133427644879093 0.0028614554432129 NA NA NA hsa-miR-138-1-3p TIA1 0.446369405595197 0.000598407910928167 -0.0181692412339762 0.773500392636888 MirTarget -0.116872356874773 9.04291843840479e-11 NA NA NA hsa-miR-139-5p TIMP3 0.647754756897662 2.1537830723695e-06 0.245539739799993 0.00694219454446388 miRanda -0.104736141481861 2.20604549708984e-05 NA NA NA hsa-miR-330-3p TIMP3 0.427388106938161 0.003004892844142 0.245539739799993 0.00694219454446388 mirMAP -0.10020300269792 9.30318781840721e-06 NA NA NA hsa-miR-330-5p TLE3 0.262932095995619 0.0465226565966542 0.0315146264556381 0.616898384895864 miRNATAP -0.18263266487568 1.03665863176083e-30 NA NA NA hsa-miR-338-3p TLE3 0.399637046793888 0.00344106432206527 0.0315146264556381 0.616898384895864 miRanda -0.129535870914105 1.02726636500413e-13 NA NA NA hsa-miR-129-5p TLR8 0.567133990117154 0.00116152215679873 -0.539068585021573 0.000153257753678494 miRanda -0.129231448246325 0.000414639983479805 NA NA NA hsa-miR-139-5p TM4SF1 0.647754756897662 2.1537830723695e-06 -0.731287498884869 1.19989249400304e-10 mirMAP -0.168698612569092 5.07144413067454e-06 NA NA NA hsa-miR-338-3p TM4SF1 0.399637046793888 0.00344106432206527 -0.731287498884869 1.19989249400304e-10 miRanda -0.155345573416645 8.54638336316998e-05 NA NA NA hsa-miR-338-3p TM4SF18 0.399637046793888 0.00344106432206527 -0.464390613553159 5.16909933911179e-08 miRanda -0.112485879044897 0.000183396854935078 NA NA NA hsa-miR-129-5p TMED7-TICAM2 0.567133990117154 0.00116152215679873 -1.05647584894717 1.94589954022484e-05 miRanda -0.161473840013809 0.0115621766761934 NA NA NA hsa-miR-490-3p TMEM106A 0.834268051506887 5.26203010743174e-06 -0.205205551026978 0.0466360766317928 miRanda -0.12199652631779 7.00568649850937e-07 NA NA NA hsa-miR-330-5p TMEM108 0.262932095995619 0.0465226565966542 0.105709750111664 0.175984761131231 miRanda -0.142323543662986 1.71402846898309e-09 NA NA NA hsa-miR-139-5p TMEM133 0.647754756897662 2.1537830723695e-06 0.138278870055834 0.0320582778341187 PITA;miRanda -0.134986716580194 3.0779032296157e-11 NA NA NA hsa-miR-139-5p TMEM140 0.647754756897662 2.1537830723695e-06 -0.314140465192441 2.43848489034427e-07 miRanda -0.129518042143385 7.73845893906844e-12 NA NA NA hsa-miR-129-5p TMEM150A 0.567133990117154 0.00116152215679873 -0.12635643743087 0.0085885359018755 miRanda -0.101647877685215 4.28475991912592e-22 NA NA NA hsa-miR-138-5p TMEM154 0.61608764992087 1.35200027885651e-05 -0.671920326082807 1.02846112022968e-10 MirTarget -0.188443007596674 6.48237206507863e-09 NA NA NA hsa-miR-138-5p TMEM37 0.61608764992087 1.35200027885651e-05 -0.431482715678638 4.33191357428604e-07 MirTarget -0.168095098869245 1.7150515203529e-10 NA NA NA hsa-miR-139-5p TMEM67 0.647754756897662 2.1537830723695e-06 -0.183061990595074 0.0129691867502549 miRanda -0.170266020785834 2.66879590737951e-13 NA NA NA hsa-miR-338-3p TMEM71 0.399637046793888 0.00344106432206527 -1.10335919960407 1.39286668565814e-14 miRanda -0.166270151689645 0.00130785204022252 NA NA NA hsa-miR-139-5p TMOD3 0.647754756897662 2.1537830723695e-06 -0.204497788679515 0.000729131417150186 miRanda -0.14389818008819 2.87151857804158e-17 NA NA NA hsa-miR-139-5p TMPO 0.647754756897662 2.1537830723695e-06 -0.301360793196896 1.72097092176698e-07 MirTarget;miRNATAP -0.103079050496861 2.45916121171763e-10 NA NA NA hsa-miR-338-5p TMPO 0.424003687569646 0.00246415720301228 -0.301360793196896 1.72097092176698e-07 MirTarget -0.10047321231375 1.11852936223808e-10 NA NA NA hsa-miR-139-5p TMPRSS2 0.647754756897662 2.1537830723695e-06 0.106619102178694 0.486270598133522 miRanda -0.147340551587256 0.00336041075145718 NA NA NA hsa-miR-330-5p TMSB15B 0.262932095995619 0.0465226565966542 -0.0939822649274604 0.215801271918336 miRanda -0.147314375110848 2.11079076185478e-09 NA NA NA hsa-miR-139-5p TMX1 0.647754756897662 2.1537830723695e-06 -0.164842811447974 0.00337398173355225 miRanda -0.175242778621194 1.03522097603486e-36 NA NA NA hsa-miR-129-5p TNC 0.567133990117154 0.00116152215679873 -0.55513797715365 5.94265484482904e-05 miRanda -0.149509764155064 9.83486700574452e-06 NA NA NA hsa-miR-129-5p TNFAIP8 0.567133990117154 0.00116152215679873 -0.771372431654312 1.70086464834287e-13 miRanda -0.166562278577386 7.6229557090407e-10 NA NA NA hsa-miR-338-3p TNFAIP8 0.399637046793888 0.00344106432206527 -0.771372431654312 1.70086464834287e-13 miRanda -0.190316998462006 3.65901439574104e-07 NA NA NA hsa-miR-490-3p TNFAIP8 0.834268051506887 5.26203010743174e-06 -0.771372431654312 1.70086464834287e-13 miRanda -0.181594078924889 7.02214305321623e-13 NA NA NA hsa-miR-139-5p TNFRSF10D 0.647754756897662 2.1537830723695e-06 -0.316660929389005 0.000315848582429912 miRanda -0.11935610561564 3.25321994093021e-05 NA NA NA hsa-miR-338-3p TNFRSF11B 0.399637046793888 0.00344106432206527 -1.26162757466273 7.44220541760423e-14 miRanda -0.191014167054792 0.00169474493279753 NA NA NA hsa-miR-129-5p TNFRSF19 0.567133990117154 0.00116152215679873 -0.370644875543523 0.00101074293886294 miRanda -0.139421861413054 6.09727552038696e-07 NA NA NA hsa-miR-338-5p TNFRSF19 0.424003687569646 0.00246415720301228 -0.370644875543523 0.00101074293886294 mirMAP -0.16099910988263 3.12211037963851e-06 NA NA NA hsa-miR-490-3p TNFRSF19 0.834268051506887 5.26203010743174e-06 -0.370644875543523 0.00101074293886294 miRanda -0.127316134349461 1.29638113855038e-06 NA NA NA hsa-miR-330-5p TNFRSF8 0.262932095995619 0.0465226565966542 -0.22605644418637 0.190623764790906 miRanda -0.115196291772202 0.04504301633172 NA NA NA hsa-miR-139-5p TNFSF10 0.647754756897662 2.1537830723695e-06 -0.394738086337689 7.46036026829107e-05 miRanda -0.111786211059875 0.000654822266934151 NA NA NA hsa-miR-129-5p TNFSF8 0.567133990117154 0.00116152215679873 -0.248874309212129 0.0614650119398425 miRanda -0.12557046268516 0.000222562780238742 NA NA NA hsa-miR-129-5p TNIP2 0.567133990117154 0.00116152215679873 -0.0910103485285072 0.161752858487664 MirTarget -0.141978829947631 1.75277667434341e-23 NA NA NA hsa-miR-330-5p TNK2 0.262932095995619 0.0465226565966542 0.522871634717651 4.89917336868688e-08 miRanda;miRNATAP -0.140550869094052 6.63326541692339e-07 NA NA NA hsa-miR-139-5p TNPO1 0.647754756897662 2.1537830723695e-06 -0.135824964938614 0.0157836321898429 MirTarget;PITA;miRanda -0.101974002843236 5.98779006253903e-15 NA NA NA hsa-miR-330-5p TNRC18 0.262932095995619 0.0465226565966542 -0.0721521106349821 0.210760132651975 miRanda -0.129087338927268 3.46970879434113e-21 NA NA NA hsa-miR-139-5p TOP2A 0.647754756897662 2.1537830723695e-06 -1.82439905333967 2.82204418782836e-19 miRanda -0.411612017376929 1.70963501497242e-09 26079880 We identified that miR-139 a previous reported anti-metastatic microRNA targets 3'-untranslated region 3'UTR of TOP2a mRNA; Further more we revealed that the forced expression of miR-139 reduces the TOP2a expression at both mRNA and protein levels; And our functional experiments showed that the ectopic expression of miR-139 remarkably inhibits proliferation in luminal type breast cancer cells while exogenous TOP2a expression could rescue inhibition of cell proliferation mediated by miR-139 breast cancer hsa-miR-338-3p TP53 0.399637046793888 0.00344106432206527 -0.346312114104129 1.42081328137354e-05 miRanda -0.117560999445537 4.2049029410775e-06 NA NA NA hsa-miR-129-5p TP53INP1 0.567133990117154 0.00116152215679873 -0.170274442372303 0.0104910726547083 miRNAWalker2_validate;PITA;miRanda -0.132451665209162 1.18960224751466e-18 NA NA NA hsa-miR-330-3p TP53INP1 0.427388106938161 0.003004892844142 -0.170274442372303 0.0104910726547083 mirMAP -0.121125009520984 1.7813236334496e-11 NA NA NA hsa-miR-485-3p TP53INP1 0.530677478972608 0.00148549219838864 -0.170274442372303 0.0104910726547083 mirMAP -0.143488977750226 3.8805241442275e-21 NA NA NA hsa-miR-338-3p TP63 0.399637046793888 0.00344106432206527 -0.407293261131459 0.000954990159634494 miRanda -0.102302440251788 0.0185262894445385 NA NA NA hsa-miR-138-5p TP73 0.61608764992087 1.35200027885651e-05 -0.964090476895587 5.59044169933305e-09 MirTarget -0.234483508402263 5.94793628771871e-06 NA NA NA hsa-miR-138-5p TPM4 0.61608764992087 1.35200027885651e-05 -0.436047146922176 1.13662915419365e-11 miRNATAP -0.11462005211408 6.87512386989392e-13 NA NA NA hsa-miR-139-5p TRAF3IP3 0.647754756897662 2.1537830723695e-06 -0.383256182259868 0.00163313252893439 miRanda -0.255396710973728 1.22878539419633e-10 NA NA NA hsa-miR-330-5p TRAF4 0.262932095995619 0.0465226565966542 -0.221757102835578 0.00709318578689758 miRanda -0.124458994207065 4.41323516054525e-07 NA NA NA hsa-miR-139-5p TRAFD1 0.647754756897662 2.1537830723695e-06 -0.11591334425106 0.0122076551024853 miRanda -0.11127065499239 3.82373314182685e-29 NA NA NA hsa-miR-139-5p TRAIP 0.647754756897662 2.1537830723695e-06 -0.544493795442949 4.09303285081173e-13 miRanda -0.132090632462334 1.28555531316503e-07 NA NA NA hsa-miR-330-5p TRAIP 0.262932095995619 0.0465226565966542 -0.544493795442949 4.09303285081173e-13 miRanda -0.13013411328067 2.37004307626067e-07 NA NA NA hsa-miR-138-5p TRAM1 0.61608764992087 1.35200027885651e-05 -0.219249743549408 6.52057084378379e-05 MirTarget;miRNATAP -0.111463208166806 1.46209024045544e-17 NA NA NA hsa-miR-138-5p TRAM2 0.61608764992087 1.35200027885651e-05 -0.477501519025737 8.94446855861215e-11 mirMAP -0.161803535839331 6.31810396604652e-14 NA NA NA hsa-miR-490-3p TRAM2 0.834268051506887 5.26203010743174e-06 -0.477501519025737 8.94446855861215e-11 mirMAP -0.122384428785095 2.89721695565042e-13 NA NA NA hsa-miR-139-5p TRIB2 0.647754756897662 2.1537830723695e-06 -0.266872034798271 0.00199622344818235 miRanda -0.105519735587597 6.26099465222115e-05 NA NA NA hsa-miR-338-3p TRIB2 0.399637046793888 0.00344106432206527 -0.266872034798271 0.00199622344818235 miRanda -0.126818479326463 6.18599676077129e-06 NA NA NA hsa-miR-139-5p TRIM24 0.647754756897662 2.1537830723695e-06 -0.208358162055585 0.000432257558712726 miRanda -0.110807020812567 1.69113947095789e-11 NA NA NA hsa-miR-330-3p TRIM24 0.427388106938161 0.003004892844142 -0.208358162055585 0.000432257558712726 mirMAP -0.106111509812262 1.82572010639915e-12 NA NA NA hsa-miR-338-3p TRIM4 0.399637046793888 0.00344106432206527 -0.0698448904176612 0.196026683167924 miRanda -0.111809387236238 7.2523593801449e-13 NA NA NA hsa-miR-490-3p TRIM47 0.834268051506887 5.26203010743174e-06 -0.204167493305074 0.0189007314003846 miRanda;miRNATAP -0.13182381692943 3.26082056664388e-12 NA NA NA hsa-miR-129-5p TRIM5 0.567133990117154 0.00116152215679873 -0.331677944875737 0.000151720319154717 miRanda -0.151757257274928 1.9129206846555e-12 NA NA NA hsa-miR-338-5p TRIM5 0.424003687569646 0.00246415720301228 -0.331677944875737 0.000151720319154717 mirMAP -0.12876991600299 1.73140244100569e-06 NA NA NA hsa-miR-139-5p TRIM6 0.647754756897662 2.1537830723695e-06 -0.392933795888304 0.000268787031181975 miRanda -0.223276583103309 2.33667891685126e-10 NA NA NA hsa-miR-330-3p TRIM9 0.427388106938161 0.003004892844142 0.0187324302090888 0.799389498159473 mirMAP -0.110389302528713 1.08310922211591e-10 NA NA NA hsa-miR-138-5p TRIOBP 0.61608764992087 1.35200027885651e-05 -0.147441285271851 0.00203608986699772 mirMAP -0.112892443655483 1.36465766006713e-25 NA NA NA hsa-miR-129-5p TRIP10 0.567133990117154 0.00116152215679873 -0.399013398302209 7.87952504131513e-07 miRanda -0.158190672365033 7.89964238117508e-16 NA NA NA hsa-miR-330-5p TRIP10 0.262932095995619 0.0465226565966542 -0.399013398302209 7.87952504131513e-07 miRanda -0.115230160430613 9.42732775927109e-06 NA NA NA hsa-miR-338-3p TRMT5 0.399637046793888 0.00344106432206527 0.139431513163983 0.0182419702419033 PITA -0.105941515179413 4.03243682783576e-09 NA NA NA hsa-miR-330-5p TSEN54 0.262932095995619 0.0465226565966542 -0.122078033145029 0.02704950670485 miRNATAP -0.101908730665545 7.15203766024755e-10 NA NA NA hsa-miR-330-3p TSHR 0.427388106938161 0.003004892844142 1.14527993852672 7.64490151551358e-07 MirTarget -0.248178526325949 0.000432251100775009 NA NA NA hsa-miR-338-3p TSKU 0.399637046793888 0.00344106432206527 -0.212119799645135 0.00132058402385938 mirMAP -0.156298526448335 1.58157991047994e-13 NA NA NA hsa-miR-490-3p TSPAN6 0.834268051506887 5.26203010743174e-06 -0.135245003643748 0.0373902004024003 miRanda -0.108100031865876 6.0971033246977e-16 NA NA NA hsa-miR-139-5p TTC21A 0.647754756897662 2.1537830723695e-06 0.0497300336899835 0.519265908683077 miRanda -0.122710958822317 8.56160093470115e-07 NA NA NA hsa-miR-330-3p TTC31 0.427388106938161 0.003004892844142 -0.128164638272027 0.00834567310545717 mirMAP -0.105798693416257 1.54240117697044e-16 NA NA NA hsa-miR-129-5p TTK 0.567133990117154 0.00116152215679873 -1.68596043296831 1.79039411963732e-22 miRanda -0.238655417869114 1.93024342130145e-07 NA NA NA hsa-miR-139-5p TTK 0.647754756897662 2.1537830723695e-06 -1.68596043296831 1.79039411963732e-22 miRanda -0.349272498859988 2.94001110136929e-09 NA NA NA hsa-miR-338-5p TTK 0.424003687569646 0.00246415720301228 -1.68596043296831 1.79039411963732e-22 PITA -0.267401682568628 2.38370224047844e-06 NA NA NA hsa-miR-490-3p TUBB6 0.834268051506887 5.26203010743174e-06 -0.656477612265785 4.54724951878843e-11 miRanda -0.136422207939287 7.05060336144258e-09 NA NA NA hsa-miR-139-5p TULP3 0.647754756897662 2.1537830723695e-06 -0.18410974672546 0.000536253555491011 miRanda -0.111361269787422 2.16846897237951e-13 NA NA NA hsa-miR-139-5p TWF1 0.647754756897662 2.1537830723695e-06 -0.0134015938841712 0.793633332287009 miRanda -0.110224556481882 2.49579886039289e-20 NA NA NA hsa-miR-139-5p TWSG1 0.647754756897662 2.1537830723695e-06 -0.20312174306004 0.00301094657372595 miRanda -0.176609291660777 8.89461360391116e-19 NA NA NA hsa-miR-139-5p TXNDC17 0.647754756897662 2.1537830723695e-06 -0.127100432901854 0.00674903681420311 miRanda -0.120475236751438 1.95057673346701e-22 NA NA NA hsa-miR-139-5p TXNIP 0.647754756897662 2.1537830723695e-06 0.00762634231189629 0.92254930130747 miRanda -0.142534068485612 3.90020501728879e-12 NA NA NA hsa-miR-490-3p TYMP 0.834268051506887 5.26203010743174e-06 -0.93446385215426 1.96580764047086e-10 miRanda -0.272629009339209 7.72953209823846e-15 NA NA NA hsa-miR-129-5p TYMS 0.567133990117154 0.00116152215679873 -0.924097549543273 1.22220123208472e-14 miRanda -0.152350369924843 9.33660242208528e-07 NA NA NA hsa-miR-330-5p TYSND1 0.262932095995619 0.0465226565966542 0.0928755982847349 0.124101195053101 miRNATAP -0.117937368884468 9.31948533883364e-11 NA NA NA hsa-miR-129-5p UBD 0.567133990117154 0.00116152215679873 -0.519621866299428 0.00177052862809778 miRanda -0.166442847622208 9.38109031610267e-05 NA NA NA hsa-miR-330-5p UCN 0.262932095995619 0.0465226565966542 0.185132604153972 0.10587778218931 miRanda -0.29913155212022 6.30137922018077e-16 NA NA NA hsa-miR-139-5p UHRF1 0.647754756897662 2.1537830723695e-06 -0.313534639626736 0.0017206685654943 miRanda -0.241276781907153 5.61573799104067e-15 NA NA NA hsa-miR-338-3p ULBP1 0.399637046793888 0.00344106432206527 -0.799000889971949 1.27799883799215e-06 miRanda -0.257537410479021 8.50851666728098e-06 NA NA NA hsa-miR-129-5p UNC13D 0.567133990117154 0.00116152215679873 -0.0617327351316064 0.452842166213249 miRanda -0.146446104263349 2.49005204380568e-13 NA NA NA hsa-miR-139-5p UNC45A 0.647754756897662 2.1537830723695e-06 -0.200495972832531 0.000308854206624266 MirTarget;miRanda -0.103389345785336 4.04293843503899e-13 NA NA NA hsa-miR-129-5p USP3 0.567133990117154 0.00116152215679873 0.023888711324596 0.683097150314927 miRanda -0.101853887445715 3.27343347353233e-15 NA NA NA hsa-miR-330-5p USP3 0.262932095995619 0.0465226565966542 0.023888711324596 0.683097150314927 miRanda -0.181663394247834 6.6329473924191e-29 NA NA NA hsa-miR-338-3p USP42 0.399637046793888 0.00344106432206527 -0.145348468702277 0.000517697174268754 miRanda -0.108045730378926 4.91930563954777e-21 NA NA NA hsa-miR-139-5p UST 0.647754756897662 2.1537830723695e-06 0.0822413638317547 0.354812062903282 PITA;miRanda -0.102979073744747 0.000107686697172172 NA NA NA hsa-miR-338-5p UST 0.424003687569646 0.00246415720301228 0.0822413638317547 0.354812062903282 PITA;miRNATAP -0.107457323006497 2.36396634025972e-05 NA NA NA hsa-miR-139-5p VANGL1 0.647754756897662 2.1537830723695e-06 -0.393332765138494 4.89293584052017e-07 miRanda -0.221487304140591 1.63219264969646e-19 NA NA NA hsa-miR-485-3p VANGL1 0.530677478972608 0.00148549219838864 -0.393332765138494 4.89293584052017e-07 mirMAP -0.110906513809924 2.18453031637113e-08 NA NA NA hsa-miR-139-5p VANGL2 0.647754756897662 2.1537830723695e-06 0.0359057493022616 0.605188496685676 miRanda -0.165175847058755 3.53881829823352e-20 NA NA NA hsa-miR-485-3p VANGL2 0.530677478972608 0.00148549219838864 0.0359057493022616 0.605188496685676 mirMAP -0.152163530262258 1.06388272867884e-27 NA NA NA hsa-miR-338-3p VASP 0.399637046793888 0.00344106432206527 -0.354655334075828 3.65030700259276e-08 miRanda -0.11601190156012 1.77870599361895e-08 NA NA NA hsa-miR-129-5p VAT1 0.567133990117154 0.00116152215679873 -0.23228136427955 0.000270335950258066 mirMAP -0.117859510496592 1.48559964137901e-22 NA NA NA hsa-miR-490-3p VAT1 0.834268051506887 5.26203010743174e-06 -0.23228136427955 0.000270335950258066 MirTarget;miRanda -0.132570191383726 6.95319573965986e-33 NA NA NA hsa-miR-490-3p VCAM1 0.834268051506887 5.26203010743174e-06 -0.199969614146386 0.256903465114621 miRanda -0.163847798292313 8.966420072783e-05 NA NA NA hsa-miR-485-3p VCAN 0.530677478972608 0.00148549219838864 0.0974015294136503 0.346760313971963 MirTarget;miRNATAP -0.160493181317393 1.76073675211055e-12 NA NA NA hsa-miR-490-3p VCAN 0.834268051506887 5.26203010743174e-06 0.0974015294136503 0.346760313971963 miRanda -0.117295751937622 3.27188948380318e-08 NA NA NA hsa-miR-338-3p VCL 0.399637046793888 0.00344106432206527 -0.163823845503166 0.0430636315466601 miRanda -0.154386332213005 1.83587875185612e-09 NA NA NA hsa-miR-129-5p VEGFA 0.567133990117154 0.00116152215679873 -0.545202702414803 3.65580722751304e-08 miRanda -0.178350435603243 1.58281485759764e-13 NA NA NA hsa-miR-330-3p VEGFA 0.427388106938161 0.003004892844142 -0.545202702414803 3.65580722751304e-08 miRNAWalker2_validate -0.14940180557451 2.38610841931945e-07 NA NA NA hsa-miR-338-3p VGLL4 0.399637046793888 0.00344106432206527 -0.078689339193887 0.133270029503355 miRanda -0.114878492108332 1.79791723268026e-21 NA NA NA hsa-miR-129-5p VIM 0.567133990117154 0.00116152215679873 -0.723805060907832 7.98331283128927e-07 miRNATAP -0.171900495182114 1.11784970016168e-06 NA NA NA hsa-miR-138-5p VIM 0.61608764992087 1.35200027885651e-05 -0.723805060907832 7.98331283128927e-07 miRNAWalker2_validate -0.321195743073257 2.27700846705118e-14 26796277;27049260 miR-138 overexpression also down-regulated vimentin expression and upregulated E-cadherin expression suggesting that miR-138 inhibited EMT;In addition the epithelial-mesenchymal transition EMT related markers E-cadherin or vimentin was up-regulated or down-regulated upon the overexpression of miR-138 in NSCLC cells ; breast cancer;lung squamous cell cancer hsa-miR-139-5p VWCE 0.647754756897662 2.1537830723695e-06 -0.180462516920689 0.057424062403561 miRanda -0.137222976291631 7.48152875880758e-06 NA NA NA hsa-miR-129-5p WAS 0.567133990117154 0.00116152215679873 -0.187110841019239 0.03323424934393 miRanda -0.121299416533164 2.73555190304928e-08 NA NA NA hsa-miR-330-5p WASH3P 0.262932095995619 0.0465226565966542 0.0676312975756233 0.254940442681418 miRanda -0.102491661535253 6.12149580255278e-09 NA NA NA hsa-miR-330-5p WASH7P 0.262932095995619 0.0465226565966542 0.0334131798780239 0.614653556107899 miRanda -0.113770829990509 9.53581407510077e-10 NA NA NA hsa-miR-330-5p WDR18 0.262932095995619 0.0465226565966542 -0.0128078025821203 0.82478810378181 miRanda -0.12280497029036 1.86822790753075e-13 NA NA NA hsa-miR-330-5p WDR6 0.262932095995619 0.0465226565966542 0.0842989233325522 0.151969554590414 miRanda -0.112540762145605 2.46875882107394e-20 NA NA NA hsa-miR-330-3p WDR90 0.427388106938161 0.003004892844142 -0.24026190732454 0.00324908754486999 miRNATAP -0.122589998136382 3.06429007893056e-07 NA NA NA hsa-miR-139-5p WDR93 0.647754756897662 2.1537830723695e-06 -0.170010372984233 0.0980917909724943 miRanda -0.18429781463802 3.52420216733789e-08 NA NA NA hsa-miR-129-5p WEE1 0.567133990117154 0.00116152215679873 -0.98569897499735 4.14674818907476e-22 miRanda -0.177636038803994 1.50335734789472e-11 NA NA NA hsa-miR-139-5p WEE1 0.647754756897662 2.1537830723695e-06 -0.98569897499735 4.14674818907476e-22 miRanda -0.331574814099741 1.15164959267857e-23 NA NA NA hsa-miR-338-3p WEE1 0.399637046793888 0.00344106432206527 -0.98569897499735 4.14674818907476e-22 miRanda -0.226130609893027 4.67170737175624e-10 NA NA NA hsa-miR-139-5p WLS 0.647754756897662 2.1537830723695e-06 -0.100267218085465 0.236288016849741 miRanda -0.168318008657053 4.74473168241091e-13 NA NA NA hsa-miR-129-5p WNT5A 0.567133990117154 0.00116152215679873 -0.401727178109565 0.000135878679478951 PITA;miRanda;miRNATAP -0.122949419919608 1.9178703847978e-06 NA NA NA hsa-miR-330-5p WNT5A 0.262932095995619 0.0465226565966542 -0.401727178109565 0.000135878679478951 miRanda -0.182269668340434 4.68881013813934e-08 NA NA NA hsa-miR-139-5p WWTR1 0.647754756897662 2.1537830723695e-06 -0.385658047913055 0.0025504739682091 miRanda -0.253253102831988 1.12512113896811e-09 NA NA NA hsa-miR-338-3p XRCC2 0.399637046793888 0.00344106432206527 -0.747800436516997 4.57481421454408e-13 miRanda -0.173202297128502 2.82908613496999e-06 NA NA NA hsa-miR-129-5p YBX1 0.567133990117154 0.00116152215679873 -0.255035433032653 0.00105352582513457 miRanda -0.141906752391936 4.35666008220309e-21 NA NA NA hsa-miR-338-3p ZBTB10 0.399637046793888 0.00344106432206527 -0.0333167190350974 0.611231865149489 MirTarget;PITA;miRanda;miRNATAP -0.12152320580642 3.92045793261235e-09 NA NA NA hsa-miR-330-5p ZBTB12 0.262932095995619 0.0465226565966542 -0.0786877614820898 0.216648214921723 MirTarget;miRanda;miRNATAP -0.143467485518965 7.35853441472627e-14 NA NA NA hsa-miR-338-3p ZBTB20 0.399637046793888 0.00344106432206527 0.0704517263025601 0.518912297577935 miRanda -0.229721531008133 1.28141329267791e-09 NA NA NA hsa-miR-139-5p ZC3H12A 0.647754756897662 2.1537830723695e-06 -0.213921761801769 0.00769092410728195 PITA;miRanda -0.212804941621802 9.60074032952096e-17 NA NA NA hsa-miR-139-5p ZCCHC11 0.647754756897662 2.1537830723695e-06 -0.176718277125438 0.00554874090123077 miRanda -0.127321763471407 2.24920361082295e-12 NA NA NA hsa-miR-139-5p ZFP36L1 0.647754756897662 2.1537830723695e-06 -0.0625358944561292 0.466053238854919 miRanda -0.171205536780744 7.25264255321889e-13 NA NA NA hsa-miR-129-5p ZFP36L2 0.567133990117154 0.00116152215679873 -0.383760120585957 4.15502847929805e-07 PITA;miRanda -0.170952281518231 2.50407192755714e-26 NA NA NA hsa-miR-138-1-3p ZFP36L2 0.446369405595197 0.000598407910928167 -0.383760120585957 4.15502847929805e-07 MirTarget -0.219608174047338 1.36217872614059e-24 NA NA NA hsa-miR-138-5p ZFP36L2 0.61608764992087 1.35200027885651e-05 -0.383760120585957 4.15502847929805e-07 MirTarget;miRNATAP -0.236610398696572 4.76362118337576e-35 NA NA NA hsa-miR-139-5p ZFP36L2 0.647754756897662 2.1537830723695e-06 -0.383760120585957 4.15502847929805e-07 miRanda -0.277726784849596 8.56551739104827e-44 NA NA NA hsa-miR-338-3p ZFP36L2 0.399637046793888 0.00344106432206527 -0.383760120585957 4.15502847929805e-07 miRanda -0.182338417392372 7.77049848348275e-16 NA NA NA hsa-miR-338-5p ZFP36L2 0.424003687569646 0.00246415720301228 -0.383760120585957 4.15502847929805e-07 miRNATAP -0.161432686567669 1.98965888705864e-15 NA NA NA hsa-miR-129-5p ZFY 0.567133990117154 0.00116152215679873 -0.181264871246231 0.652891418570312 miRanda;miRNATAP -0.212633346474893 0.0397249715025036 NA NA NA hsa-miR-330-5p ZHX2 0.262932095995619 0.0465226565966542 0.17253650912107 0.0116367036174517 MirTarget -0.122695976677096 2.56450224072137e-11 NA NA NA hsa-miR-139-5p ZIC1 0.647754756897662 2.1537830723695e-06 -0.533368390782826 1.1026506233045e-06 PITA;miRanda -0.147022298951224 4.38556321841843e-05 NA NA NA hsa-miR-330-3p ZIC3 0.427388106938161 0.003004892844142 -0.00116494039697246 0.990058170502115 PITA -0.162835247610948 4.26445120356898e-09 NA NA NA hsa-miR-139-5p ZIK1 0.647754756897662 2.1537830723695e-06 -0.227377083538306 0.000255313663065116 miRanda -0.138310307115728 7.54389190885142e-13 NA NA NA hsa-miR-139-5p ZNF100 0.647754756897662 2.1537830723695e-06 -0.0793008734506064 0.143940934416902 miRanda -0.10631230641356 4.42170955189203e-11 NA NA NA hsa-miR-485-3p ZNF100 0.530677478972608 0.00148549219838864 -0.0793008734506064 0.143940934416902 PITA -0.112893929914002 1.86197392539968e-19 NA NA NA hsa-miR-139-5p ZNF107 0.647754756897662 2.1537830723695e-06 -0.197723598409077 0.0016571746724014 MirTarget;miRanda -0.134989033189013 1.46540624881121e-12 NA NA NA hsa-miR-330-5p ZNF141 0.262932095995619 0.0465226565966542 0.0241663629021041 0.631107584382748 miRanda -0.118511151294616 5.26740093101537e-14 NA NA NA hsa-miR-139-5p ZNF181 0.647754756897662 2.1537830723695e-06 -0.0272060091650381 0.594827346902223 MirTarget;miRanda -0.122504468807562 4.65445739421839e-18 NA NA NA hsa-miR-330-5p ZNF20 0.262932095995619 0.0465226565966542 -0.285518814370636 1.35116641399827e-10 miRanda -0.108174896709914 3.9717098625786e-15 NA NA NA hsa-miR-338-3p ZNF20 0.399637046793888 0.00344106432206527 -0.285518814370636 1.35116641399827e-10 miRanda -0.113062409376892 9.97595444345017e-15 NA NA NA hsa-miR-139-5p ZNF217 0.647754756897662 2.1537830723695e-06 -0.474105007236816 3.45168745618393e-10 miRanda -0.247351105544404 4.36116593020855e-26 NA NA NA hsa-miR-338-3p ZNF217 0.399637046793888 0.00344106432206527 -0.474105007236816 3.45168745618393e-10 MirTarget;miRanda -0.168429334382049 6.51295993341302e-11 NA NA NA hsa-miR-139-5p ZNF234 0.647754756897662 2.1537830723695e-06 -0.147987387773032 0.0184582607041036 miRanda -0.118943541520691 7.49190432895198e-10 NA NA NA hsa-miR-139-5p ZNF260 0.647754756897662 2.1537830723695e-06 -0.128758016198466 0.019342207125555 miRanda -0.131362943429048 1.0275306776299e-18 NA NA NA hsa-miR-338-3p ZNF28 0.399637046793888 0.00344106432206527 -0.307688276916979 1.26219240495776e-06 miRanda -0.121614839548378 5.11546704613571e-09 NA NA NA hsa-miR-338-3p ZNF286A 0.399637046793888 0.00344106432206527 -0.137513093503618 0.0121690497891778 miRanda -0.103987055951578 3.79473239094276e-10 NA NA NA hsa-miR-338-3p ZNF286B 0.399637046793888 0.00344106432206527 -0.077721944407088 0.181226960220821 miRanda -0.100691244457493 2.82725906439251e-07 NA NA NA hsa-miR-338-5p ZNF300 0.424003687569646 0.00246415720301228 -0.228085758534871 0.00590769654312143 mirMAP;miRNATAP -0.141556953276212 1.67387264534348e-08 NA NA NA hsa-miR-139-5p ZNF302 0.647754756897662 2.1537830723695e-06 0.0276434711887816 0.602011598018374 miRanda -0.103196584015711 9.13573488598966e-15 NA NA NA hsa-miR-330-5p ZNF337 0.262932095995619 0.0465226565966542 0.00513091421792389 0.932553706367494 miRanda -0.150256839515876 1.16753794465894e-18 NA NA NA hsa-miR-139-5p ZNF367 0.647754756897662 2.1537830723695e-06 -0.815545178852912 4.94616198991987e-23 miRanda -0.181538937016447 5.39535557364739e-11 NA NA NA hsa-miR-330-3p ZNF367 0.427388106938161 0.003004892844142 -0.815545178852912 4.94616198991987e-23 miRNATAP -0.116866965315982 5.12776266085803e-06 NA NA NA hsa-miR-338-5p ZNF367 0.424003687569646 0.00246415720301228 -0.815545178852912 4.94616198991987e-23 PITA;mirMAP -0.103858427275198 0.000109375935873863 NA NA NA hsa-miR-330-3p ZNF423 0.427388106938161 0.003004892844142 0.212125292174478 0.00527852468882799 MirTarget;PITA;miRNATAP -0.106899106204076 2.56333385217364e-07 NA NA NA hsa-miR-330-5p ZNF423 0.262932095995619 0.0465226565966542 0.212125292174478 0.00527852468882799 miRanda -0.140018051926911 6.34944045463748e-10 NA NA NA hsa-miR-139-5p ZNF431 0.647754756897662 2.1537830723695e-06 -0.145343609352411 0.0100988900604012 miRanda -0.108994049915724 8.36780476510062e-10 NA NA NA hsa-miR-139-5p ZNF439 0.647754756897662 2.1537830723695e-06 -0.0804866893230547 0.157204271553848 miRanda -0.101179568111942 6.14821683369183e-09 NA NA NA hsa-miR-139-5p ZNF473 0.647754756897662 2.1537830723695e-06 -0.297656388822296 6.39582432882087e-10 miRanda -0.11562734265132 3.68740617512205e-16 NA NA NA hsa-miR-338-3p ZNF474 0.399637046793888 0.00344106432206527 -0.621783778167128 1.11817432073943e-05 miRanda -0.163377595862434 0.00106973896621345 NA NA NA hsa-miR-338-3p ZNF480 0.399637046793888 0.00344106432206527 -0.245833530547941 1.35790712362376e-06 MirTarget;miRanda -0.110260623240591 4.4101960982801e-12 NA NA NA hsa-miR-338-3p ZNF559 0.399637046793888 0.00344106432206527 -0.0541741339183499 0.335357423242844 miRanda -0.110821011631881 3.73918579251104e-10 NA NA NA hsa-miR-139-5p ZNF560 0.647754756897662 2.1537830723695e-06 0.340243673100536 0.211236362891476 miRanda -0.283059518090863 0.00162370123358848 NA NA NA hsa-miR-139-5p ZNF577 0.647754756897662 2.1537830723695e-06 -0.156042144839218 0.0207459883938132 miRanda -0.147803981372909 2.03015849588122e-12 NA NA NA hsa-miR-139-5p ZNF649 0.647754756897662 2.1537830723695e-06 -0.10289600560385 0.120114926874026 miRanda -0.102883274078677 2.62279586615296e-07 NA NA NA hsa-miR-338-3p ZNF660 0.399637046793888 0.00344106432206527 -0.0701413229147219 0.421154110704358 mirMAP -0.126112447373341 3.36113062081204e-05 NA NA NA hsa-miR-139-5p ZNF662 0.647754756897662 2.1537830723695e-06 -0.0174050284564782 0.895340634673398 miRanda -0.181364386027308 2.34170652902717e-05 NA NA NA hsa-miR-139-5p ZNF677 0.647754756897662 2.1537830723695e-06 -0.149654156439411 0.0147930407795112 MirTarget;miRanda -0.119104423663144 1.05825002688611e-09 NA NA NA hsa-miR-338-3p ZNF678 0.399637046793888 0.00344106432206527 -0.00985694896595679 0.91243419453717 miRanda -0.137567612555516 9.99502511397671e-06 NA NA NA hsa-miR-330-3p ZNF681 0.427388106938161 0.003004892844142 0.106544257323089 0.217028009001284 mirMAP -0.114947838139613 5.30158849551738e-06 NA NA NA hsa-miR-338-3p ZNF709 0.399637046793888 0.00344106432206527 -0.0759552889495785 0.0530987390033623 miRanda -0.108121318153639 2.12611565911113e-19 NA NA NA hsa-miR-139-5p ZNF792 0.647754756897662 2.1537830723695e-06 -0.149483552306808 0.00233750554518826 MirTarget;miRanda -0.164026005508213 3.18999258711155e-27 NA NA NA hsa-miR-338-3p ZNF800 0.399637046793888 0.00344106432206527 -0.0790089483301326 0.113038640562929 miRanda -0.122946887710536 2.53610771953607e-15 NA NA NA hsa-miR-139-5p ZNF805 0.647754756897662 2.1537830723695e-06 -0.121422390074451 0.00947390735646203 mirMAP -0.107426066531717 1.67845474932222e-16 NA NA NA hsa-miR-330-5p ZNF814 0.262932095995619 0.0465226565966542 -0.0703480205913563 0.248775293302956 miRanda -0.110709818464779 1.96631088564321e-09 NA NA NA hsa-miR-330-5p ZNF823 0.262932095995619 0.0465226565966542 -0.0780220588684093 0.0998434829274497 miRanda -0.10438611081707 3.59168420971965e-12 NA NA NA hsa-miR-338-3p ZNF90 0.399637046793888 0.00344106432206527 -0.394626861715955 1.17361856555125e-07 miRanda -0.170889143418648 3.17336283332192e-11 NA NA NA hsa-miR-139-5p ZNF93 0.647754756897662 2.1537830723695e-06 -0.173481866559483 0.0280238296896325 miRanda -0.122041516995307 1.9488170160141e-06 NA NA NA hsa-miR-139-5p ZNRF2 0.647754756897662 2.1537830723695e-06 -0.14694277630725 0.00949219642010232 miRanda -0.108600093906447 8.95019955813584e-10 NA NA NA hsa-miR-330-5p ZWINT 0.262932095995619 0.0465226565966542 -0.767560474734747 1.11290010099689e-14 miRanda -0.108339253119389 0.00119631572900304 NA NA NA hsa-miR-338-3p ZWINT 0.399637046793888 0.00344106432206527 -0.767560474734747 1.11290010099689e-14 miRanda -0.10862221744499 0.00219286658526807 NA NA NA hsa-miR-490-3p ZYX 0.834268051506887 5.26203010743174e-06 -0.507097731185305 9.59533277074484e-13 miRanda -0.133777087388729 1.30324173486401e-19 NA NA NA