miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-140-5p ABCD3 -0.755971041589807 9.68060922934542e-14 0.3559727720477 0.000198172014246611 miRanda -0.178262696010917 2.04710270741745e-08 NA NA NA hsa-miR-152-3p ABCD3 -0.26603867075042 0.0063861560676033 0.3559727720477 0.000198172014246611 MirTarget -0.152089371176917 6.34361165824393e-06 NA NA NA hsa-miR-140-5p ABHD1 -0.755971041589807 9.68060922934542e-14 -0.979242702067246 7.11422819612358e-10 miRanda -0.134922629763022 0.0118381107323936 NA NA NA hsa-miR-34a-5p ABHD2 0.129201805242403 0.133261654068224 0.450213534981843 0.000527417369441251 mirMAP -0.123265010863648 0.018349951430513 NA NA NA hsa-miR-194-5p ACADSB 0.467781870340114 1.0386810618625e-07 -0.519397273275526 0.00199932436563489 mirMAP -0.232605693110579 0.000382362927077778 NA NA NA hsa-miR-34a-5p ACSL4 0.129201805242403 0.133261654068224 -1.47773903295013 8.01517847091735e-37 miRNAWalker2_validate;MirTarget;miRNATAP -0.108495513869246 0.0267693955962344 NA NA NA hsa-miR-34a-5p ADAM22 0.129201805242403 0.133261654068224 -1.22400577928345 9.86358971049703e-10 MirTarget;miRNATAP -0.327154407279799 5.3319488768237e-05 NA NA NA hsa-miR-140-5p ADAMTS13 -0.755971041589807 9.68060922934542e-14 0.49002440332112 0.000583985090350807 mirMAP -0.38449427664132 2.29243341080302e-16 NA NA NA hsa-miR-152-3p ADAMTS19 -0.26603867075042 0.0063861560676033 0.714072520384231 0.0288084514634016 MirTarget -0.358871464700212 0.00184013470657074 NA NA NA hsa-miR-194-5p ADAMTS5 0.467781870340114 1.0386810618625e-07 -3.55145538959317 1.2022506062627e-103 mirMAP -0.423726324643261 4.72393141593673e-09 NA NA NA hsa-miR-140-5p ADCY1 -0.755971041589807 9.68060922934542e-14 -0.0486801025784516 0.841490665662841 mirMAP -0.431992460904054 8.66012349155864e-08 NA NA NA hsa-miR-34a-5p ADCY1 0.129201805242403 0.133261654068224 -0.0486801025784516 0.841490665662841 mirMAP -0.242406506512429 0.0130353925733776 NA NA NA hsa-miR-140-5p ADCY6 -0.755971041589807 9.68060922934542e-14 -0.631200513666625 6.14065292828624e-14 MirTarget;PITA;miRanda;miRNATAP -0.161009279361508 1.24789237992642e-08 NA NA NA hsa-miR-34a-5p AFAP1L2 0.129201805242403 0.133261654068224 -1.15376851508751 1.13039394747189e-19 miRNAWalker2_validate -0.127651134382524 0.0144966391756509 NA NA NA hsa-miR-194-5p AFF2 0.467781870340114 1.0386810618625e-07 -1.77942132767396 7.49943468170474e-23 mirMAP -0.184154664222054 0.0109821433229211 NA NA NA hsa-miR-34a-5p AHNAK 0.129201805242403 0.133261654068224 -1.76535987346934 5.20116033627817e-56 miRNAWalker2_validate -0.148753361821443 0.0020126364993857 NA NA NA hsa-miR-34a-5p AKAP13 0.129201805242403 0.133261654068224 -0.608726058300724 5.65488571630791e-18 mirMAP -0.106975747301127 0.000200284025442049 NA NA NA hsa-miR-34a-5p AKAP6 0.129201805242403 0.133261654068224 -2.28015270926059 6.96245937007291e-60 MirTarget -0.134956464157299 0.0256977219723797 NA NA NA hsa-miR-194-5p ALDH1L2 0.467781870340114 1.0386810618625e-07 -0.0393531240213658 0.786156469224884 mirMAP -0.200613052852648 0.000370757893934166 NA NA NA hsa-miR-140-5p ALOX15B -0.755971041589807 9.68060922934542e-14 -0.746407956123036 0.0190798980112086 miRanda -0.246737911926389 0.0204965037197789 NA NA NA hsa-miR-34a-5p ALX4 0.129201805242403 0.133261654068224 -3.21510012414237 4.06971831531578e-34 mirMAP -0.46674886234663 2.27336264532142e-05 NA NA NA hsa-miR-140-5p AMACR -0.755971041589807 9.68060922934542e-14 0.527580762991154 1.48958594404422e-10 miRanda -0.145878863875012 1.25840122101392e-07 NA NA NA hsa-miR-194-5p ANGPTL1 0.467781870340114 1.0386810618625e-07 -3.72061004689091 3.17960434867383e-73 MirTarget -0.554965429200241 1.7795021002207e-10 NA NA NA hsa-miR-34a-5p ANK2 0.129201805242403 0.133261654068224 -2.50568252042295 2.12750718019692e-56 MirTarget;miRNATAP -0.316399585255762 3.20345722430936e-06 NA NA NA hsa-miR-34a-5p ANK3 0.129201805242403 0.133261654068224 -0.025345097787647 0.843322595909416 miRNATAP -0.142764848247394 0.00546629790691742 NA NA NA hsa-miR-140-5p ANKRD42 -0.755971041589807 9.68060922934542e-14 0.219656120252056 0.0121262001896109 MirTarget;miRanda -0.213290799328015 1.37941833686383e-13 NA NA NA hsa-miR-140-5p ANKRD52 -0.755971041589807 9.68060922934542e-14 0.229691819057689 0.000236198445012247 PITA;miRanda;miRNATAP -0.11694180123912 1.67024488259162e-08 NA NA NA hsa-miR-34a-5p ANKS1A 0.129201805242403 0.133261654068224 -0.367774669133925 3.05939471871311e-10 MirTarget -0.100867636378822 1.84743227577203e-05 NA NA NA hsa-miR-140-5p ANKS1B -0.755971041589807 9.68060922934542e-14 0.195574172772792 0.219403504513109 miRanda -0.319032293951356 1.39906265956058e-09 NA NA NA hsa-miR-140-5p AP1AR -0.755971041589807 9.68060922934542e-14 0.37025321677178 2.99469831505099e-06 miRanda -0.114014308300478 1.67514496606669e-05 NA NA NA hsa-miR-140-5p AP2B1 -0.755971041589807 9.68060922934542e-14 0.256868055359782 0.00182779940285162 PITA;miRanda -0.128740819994083 2.65850131216944e-06 NA NA NA hsa-miR-140-5p ARFIP2 -0.755971041589807 9.68060922934542e-14 0.834135949615158 1.14769877639931e-22 PITA;miRanda -0.297412751015471 8.1565229276009e-26 NA NA NA hsa-miR-34a-5p ARHGAP19 0.129201805242403 0.133261654068224 -0.973447425093666 1.02955194197712e-41 mirMAP -0.113080874680019 0.000190783555299795 NA NA NA hsa-miR-194-5p ARHGAP24 0.467781870340114 1.0386810618625e-07 -1.40822309796801 1.02598155255413e-44 miRNATAP -0.231535419702422 1.66990789963666e-08 NA NA NA hsa-miR-140-5p ARHGAP32 -0.755971041589807 9.68060922934542e-14 0.428981349890582 9.04481455196716e-05 miRanda -0.1949674406623 8.99028144726541e-08 NA NA NA hsa-miR-194-5p ARHGAP5 0.467781870340114 1.0386810618625e-07 -0.905445537339626 5.67397960745221e-22 miRNATAP -0.181265608162716 1.22932278029341e-06 NA NA NA hsa-miR-140-5p ARHGEF18 -0.755971041589807 9.68060922934542e-14 0.600268108434419 4.72823473975603e-23 miRanda -0.113351617503513 4.04255991507366e-08 NA NA NA hsa-miR-34a-5p ARHGEF33 0.129201805242403 0.133261654068224 -0.658291874901687 5.33354315339066e-08 MirTarget -0.102438216192709 0.0364230473447023 NA NA NA hsa-miR-194-5p ARID4A 0.467781870340114 1.0386810618625e-07 -0.85847003194558 2.64031635907732e-29 miRNATAP -0.13734824789985 7.60272175870834e-06 NA NA NA hsa-miR-140-5p ARMC9 -0.755971041589807 9.68060922934542e-14 1.05145638032088 4.80180385675785e-40 miRanda -0.256640942448092 3.53389720622708e-21 NA NA NA hsa-miR-140-5p ARV1 -0.755971041589807 9.68060922934542e-14 0.718676785442534 4.37929418096289e-21 miRanda -0.125972351109316 1.20784976555357e-06 NA NA NA hsa-miR-34a-5p ASTN1 0.129201805242403 0.133261654068224 -2.96085678510482 6.59267881470187e-30 MirTarget -0.543233893086448 4.83146756119928e-07 NA NA NA hsa-miR-34a-5p ASXL2 0.129201805242403 0.133261654068224 -0.863091823045132 1.23718078543405e-08 MirTarget -0.165946938464908 0.00682059949723894 NA NA NA hsa-miR-140-5p ATG4B -0.755971041589807 9.68060922934542e-14 0.434418174646641 1.520351767586e-11 miRanda -0.107922627296708 5.92322643566214e-07 NA NA NA hsa-miR-140-5p ATP6V1G1 -0.755971041589807 9.68060922934542e-14 0.814503279860658 4.31440936817757e-37 miRanda -0.174653755898716 1.88276353881105e-15 NA NA NA hsa-miR-194-5p ATP8B4 0.467781870340114 1.0386810618625e-07 -1.46395699677557 8.64693942273057e-35 MirTarget -0.254568098890282 1.18984422719398e-07 NA NA NA hsa-miR-140-5p B3GALT6 -0.755971041589807 9.68060922934542e-14 0.688115507009264 2.89820385485931e-19 miRanda -0.163791953147542 2.57652922246501e-10 NA NA NA hsa-miR-140-5p BBC3 -0.755971041589807 9.68060922934542e-14 1.65385724902316 1.48973116107111e-30 miRNATAP -0.473628085409644 2.04784854852423e-22 NA NA NA hsa-miR-140-5p BBS4 -0.755971041589807 9.68060922934542e-14 0.0882991918413127 0.279477118263291 miRanda -0.147916836812068 4.44228580118731e-08 NA NA NA hsa-miR-34a-5p BCL2 0.129201805242403 0.133261654068224 -0.895845361347303 1.04475176246219e-07 miRNAWalker2_validate;miRTarBase -0.21690891602483 0.00143015924808101 24565525;22623155;21399894;23155233;24444609;20687223;24988056;18803879;19714243;25053345;20433755;22964582;23862748 In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression drug resistance;;;;poor survival;drug resistance;;poor survival;differentiation;poor survival;drug resistance;;; breast cancer;breast cancer;breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;lung cancer;liver cancer hsa-miR-140-5p BCL2L1 -0.755971041589807 9.68060922934542e-14 0.522792065960586 7.61639356485872e-19 PITA;miRanda;miRNATAP -0.178298678075701 1.10325405117987e-19 NA NA NA hsa-miR-140-5p BCL9 -0.755971041589807 9.68060922934542e-14 1.09379559345287 4.5908790619182e-39 MirTarget;PITA;miRanda;miRNATAP -0.20999635587831 3.74102948460038e-13 NA NA NA hsa-miR-140-5p BMP8A -0.755971041589807 9.68060922934542e-14 2.5531168368725 9.36184416259286e-78 miRanda -0.17092515217601 0.000682416339622627 NA NA NA hsa-miR-194-5p BNC1 0.467781870340114 1.0386810618625e-07 -2.83516404755252 1.43699818736979e-26 MirTarget -0.433148051436019 4.87776497293035e-05 NA NA NA hsa-miR-34a-5p BNC2 0.129201805242403 0.133261654068224 -0.776172590713737 2.35134421190691e-07 miRNATAP -0.1268055943999 0.0367557464987537 NA NA NA hsa-miR-140-5p BRD8 -0.755971041589807 9.68060922934542e-14 0.0682623092650623 0.221688260861058 miRanda -0.109152875591844 3.19244963333508e-09 NA NA NA hsa-miR-194-5p BRMS1L 0.467781870340114 1.0386810618625e-07 -0.44199060027101 1.97997757954059e-13 MirTarget -0.12130773706777 2.69160827756569e-07 NA NA NA hsa-miR-34a-5p BRPF3 0.129201805242403 0.133261654068224 0.0924754751249477 0.205867037581768 MirTarget;miRNATAP -0.1208354829057 3.47354304224124e-05 NA NA NA hsa-miR-140-5p BSN -0.755971041589807 9.68060922934542e-14 -0.241199962533755 0.13232821768252 mirMAP -0.14584612357248 0.00640152364234607 NA NA NA hsa-miR-194-5p BTBD7 0.467781870340114 1.0386810618625e-07 -0.653337440975355 2.62585942395581e-21 miRNATAP -0.106710112167199 0.000100230620035102 NA NA NA hsa-miR-34a-5p C17orf51 0.129201805242403 0.133261654068224 -1.38118393054696 1.19626145693611e-32 mirMAP -0.175978121743166 0.000276078584299147 NA NA NA hsa-miR-34a-5p C1orf21 0.129201805242403 0.133261654068224 -0.468027970401431 0.00105985509741778 mirMAP -0.146789936851505 0.0106726366586181 NA NA NA hsa-miR-152-3p CABP7 -0.26603867075042 0.0063861560676033 1.17917915211123 1.26154510930854e-12 MirTarget -0.196150045339596 0.000948803817869869 NA NA NA hsa-miR-34a-5p CACHD1 0.129201805242403 0.133261654068224 -2.56774598917352 6.13969823521877e-72 MirTarget -0.377096637267684 1.48795228140549e-09 NA NA NA hsa-miR-194-5p CADM1 0.467781870340114 1.0386810618625e-07 -0.0699204971408882 0.585878770512374 miRNATAP -0.126220074207194 0.0115012142210783 NA NA NA hsa-miR-140-5p CADPS -0.755971041589807 9.68060922934542e-14 1.85753501254861 7.37501833486831e-21 miRanda -0.290745683378493 1.72317811751774e-05 NA NA NA hsa-miR-140-5p CAMK2N1 -0.755971041589807 9.68060922934542e-14 0.270123856938859 0.0766724015071091 PITA;miRanda -0.293491381620821 6.3813103126098e-09 NA NA NA hsa-miR-140-5p CAPN1 -0.755971041589807 9.68060922934542e-14 0.603584891093352 6.70176366731414e-22 miRanda;miRNATAP -0.124957501799464 4.3750761760043e-09 NA NA NA hsa-miR-34a-5p CAPN6 0.129201805242403 0.133261654068224 -3.62270638284474 1.23690757569109e-25 miRNATAP -0.804251252102527 1.57851882946847e-08 NA NA NA hsa-miR-140-5p CARD10 -0.755971041589807 9.68060922934542e-14 -0.481500817820525 6.16535467067102e-05 miRanda -0.129080444736214 0.00133411209107199 NA NA NA hsa-miR-140-5p CASC1 -0.755971041589807 9.68060922934542e-14 0.0712048372619339 0.728770893228244 miRanda -0.538271347258604 1.36326664326045e-15 NA NA NA hsa-miR-140-5p CASD1 -0.755971041589807 9.68060922934542e-14 -0.0659140314892692 0.571307043693956 miRNAWalker2_validate -0.10486923710297 0.00691277214536681 NA NA NA hsa-miR-140-5p CBWD3 -0.755971041589807 9.68060922934542e-14 0.89217842214657 3.21894092107502e-14 miRanda -0.196656778769566 7.12806255256999e-07 NA NA NA hsa-miR-140-5p CC2D1A -0.755971041589807 9.68060922934542e-14 0.421609363041133 2.51917069410675e-08 miRanda -0.163168321925029 9.1164144308435e-11 NA NA NA hsa-miR-140-5p CCDC120 -0.755971041589807 9.68060922934542e-14 0.741431950852856 7.31082351980185e-28 miRanda -0.146342627878493 2.55548502170714e-10 NA NA NA hsa-miR-140-5p CCDC13 -0.755971041589807 9.68060922934542e-14 -0.0386440114595259 0.763048190777447 miRanda -0.117208806278116 0.00610527564034389 NA NA NA hsa-miR-140-5p CCDC30 -0.755971041589807 9.68060922934542e-14 0.188672548364217 0.10312704924639 miRanda -0.287017944062271 4.72388890589687e-14 NA NA NA hsa-miR-34a-5p CCDC50 0.129201805242403 0.133261654068224 -1.32804358916198 4.78202111890448e-88 miRNATAP -0.109182111297098 0.000253881924367025 NA NA NA hsa-miR-140-5p CCDC78 -0.755971041589807 9.68060922934542e-14 3.57928866240584 1.96822074947835e-52 miRanda -0.822633727900688 5.95599285320655e-24 NA NA NA hsa-miR-140-5p CCNB1 -0.755971041589807 9.68060922934542e-14 2.41596782139125 1.64230288731479e-82 miRanda -0.151189526798117 0.00114311498286806 NA NA NA hsa-miR-140-5p CCNF -0.755971041589807 9.68060922934542e-14 1.72141226490392 6.98913270118496e-68 miRanda -0.212568484834521 2.49917574768676e-09 NA NA NA hsa-miR-140-5p CD276 -0.755971041589807 9.68060922934542e-14 0.957090284528589 1.03993719710628e-44 miRanda -0.10453542613349 1.29301275187861e-05 NA NA NA hsa-miR-194-5p CD302 0.467781870340114 1.0386810618625e-07 -1.76613648445689 2.77167485879657e-60 mirMAP -0.212964532536407 2.3473508522448e-06 NA NA NA hsa-miR-140-5p CD46 -0.755971041589807 9.68060922934542e-14 0.224228915074335 0.00793689078944796 miRanda -0.137271205374392 1.00170506474195e-06 NA NA NA hsa-miR-194-5p CDC42BPA 0.467781870340114 1.0386810618625e-07 -0.66924322412178 9.81806271682457e-10 mirMAP -0.10345293049075 0.0163252615050596 NA NA NA hsa-miR-140-5p CDHR3 -0.755971041589807 9.68060922934542e-14 -0.461980641342429 0.0458670724274378 miRanda -0.195722873734269 0.011349830598059 NA NA NA hsa-miR-140-5p CDK1 -0.755971041589807 9.68060922934542e-14 3.03160118593687 3.86639585044826e-86 miRanda -0.137621615682083 0.016519525983217 NA NA NA hsa-miR-194-5p CDK14 0.467781870340114 1.0386810618625e-07 -0.433352050915716 5.35531560817009e-05 MirTarget -0.167566482845569 6.14665320334653e-05 NA NA NA hsa-miR-34a-5p CDKN1C 0.129201805242403 0.133261654068224 -2.10696277121193 3.07611963088364e-54 miRNATAP -0.278255101538641 1.67359419187959e-06 NA NA NA hsa-miR-140-5p CDKN3 -0.755971041589807 9.68060922934542e-14 3.0491072708159 1.5544040220051e-88 miRanda -0.137056598625281 0.016394533301342 NA NA NA hsa-miR-34a-5p CDON 0.129201805242403 0.133261654068224 -0.991164686357028 8.70119211480039e-13 miRNAWalker2_validate -0.131340195671336 0.0199571757499009 NA NA NA hsa-miR-140-5p CEACAM6 -0.755971041589807 9.68060922934542e-14 3.14788813465337 6.1411751537789e-15 miRanda -0.717663671871005 1.38417523704859e-07 NA NA NA hsa-miR-34a-5p CELF2 0.129201805242403 0.133261654068224 -2.12375294826078 1.08191631254129e-58 miRNATAP -0.14087090572291 0.0131749190290747 NA NA NA hsa-miR-140-5p CELF3 -0.755971041589807 9.68060922934542e-14 2.05567054235703 3.14124030150689e-13 miRanda -0.553887237697543 5.20462445549624e-09 NA NA NA hsa-miR-152-3p CELSR1 -0.26603867075042 0.0063861560676033 1.61634533287919 6.59604647943385e-22 MirTarget -0.235440593848878 0.000104800214513522 NA NA NA hsa-miR-152-3p CEP55 -0.26603867075042 0.0063861560676033 3.48253678531177 7.63120652593019e-89 MirTarget -0.150480827687959 0.0287951052167953 NA NA NA hsa-miR-140-5p CERCAM -0.755971041589807 9.68060922934542e-14 1.0552492107226 2.97170105719356e-25 miRanda;miRNATAP -0.247808172953348 6.97706219252096e-13 NA NA NA hsa-miR-194-5p CHD9 0.467781870340114 1.0386810618625e-07 -1.20641724676964 1.8510450370295e-34 miRNATAP -0.206355653261271 2.16566481184325e-07 NA NA NA hsa-miR-140-5p CHST15 -0.755971041589807 9.68060922934542e-14 0.524123485493991 1.74600464579203e-07 miRanda -0.225329714355308 1.37978176143432e-11 NA NA NA hsa-miR-194-5p CLDN19 0.467781870340114 1.0386810618625e-07 -4.72594955832129 1.8623163591231e-45 mirMAP -0.593110023154267 1.56194247557714e-05 NA NA NA hsa-miR-140-5p CLEC5A -0.755971041589807 9.68060922934542e-14 2.96513545031031 6.0413530716724e-58 miRanda -0.141154413810371 0.0336267928029985 NA NA NA hsa-miR-194-5p CLIP4 0.467781870340114 1.0386810618625e-07 -2.3151033395124 1.73675077418303e-45 MirTarget -0.212437552812393 0.00162077736588595 NA NA NA hsa-miR-34a-5p CLOCK 0.129201805242403 0.133261654068224 -0.444410941110669 0.00108938309187277 MirTarget -0.109730493000938 0.045076156706621 NA NA NA hsa-miR-34a-5p CNTN2 0.129201805242403 0.133261654068224 -1.15456712353161 6.34768185707336e-07 MirTarget;miRNATAP -0.267075477231993 0.00432985007920852 NA NA NA hsa-miR-152-3p COL2A1 -0.26603867075042 0.0063861560676033 -0.251803518620361 0.565281153122427 MirTarget -0.304118255698422 0.0490607796924399 NA NA NA hsa-miR-140-5p COPG2 -0.755971041589807 9.68060922934542e-14 0.248679199189896 0.000341940906197054 miRanda -0.129770747913293 1.78318595894532e-08 NA NA NA hsa-miR-140-5p COQ4 -0.755971041589807 9.68060922934542e-14 0.529153955993772 4.91390146514394e-11 miRanda -0.25202177753123 1.95808011644694e-21 NA NA NA hsa-miR-140-5p CORIN -0.755971041589807 9.68060922934542e-14 2.00447485032 9.16990923981099e-21 miRanda -0.336282387631677 4.23509359901797e-06 NA NA NA hsa-miR-140-5p CORO2A -0.755971041589807 9.68060922934542e-14 1.37654491855062 2.2362847171362e-28 MirTarget;miRanda;miRNATAP -0.292469780089477 6.28376303653676e-12 NA NA NA hsa-miR-34a-5p CR2 0.129201805242403 0.133261654068224 -0.576401573338542 0.120604799224487 MirTarget -0.329565652484468 0.0270986819903784 NA NA NA hsa-miR-140-5p CREB3L1 -0.755971041589807 9.68060922934542e-14 1.98276552200667 1.75546430825192e-32 MirTarget;miRanda;miRNATAP -0.449786908758343 3.50727194185209e-15 NA NA NA hsa-miR-140-5p CREB3L4 -0.755971041589807 9.68060922934542e-14 1.73073054414657 1.90935037753166e-37 miRanda -0.565434412243365 1.05073680508571e-35 NA NA NA hsa-miR-140-5p CROT -0.755971041589807 9.68060922934542e-14 0.037293899986957 0.777067375226551 miRNATAP -0.284020783960921 6.42511897357187e-11 NA NA NA hsa-miR-34a-5p CRY2 0.129201805242403 0.133261654068224 -1.19975346543936 7.77211531373058e-53 MirTarget -0.132776221675905 7.43045047630975e-05 NA NA NA hsa-miR-140-5p CST9L -0.755971041589807 9.68060922934542e-14 0.900727643330873 0.00141190357480774 miRanda -0.5370357248493 1.00311917288932e-08 NA NA NA hsa-miR-34a-5p CTDSP2 0.129201805242403 0.133261654068224 -0.729241442292955 1.0301540254669e-37 miRNATAP -0.144369811542568 9.8114231309258e-10 NA NA NA hsa-miR-194-5p CTDSPL 0.467781870340114 1.0386810618625e-07 -0.590202944121454 1.39580025090321e-17 mirMAP -0.14002484942411 2.87550717934588e-07 NA NA NA hsa-miR-140-5p CTSF -0.755971041589807 9.68060922934542e-14 -0.445879678584438 5.46629287526893e-05 miRanda -0.152237950635502 3.72633884885152e-05 NA NA NA hsa-miR-194-5p CTTNBP2NL 0.467781870340114 1.0386810618625e-07 -0.495802068354609 6.75793294997029e-12 MirTarget -0.11128021303713 8.88201227678531e-05 NA NA NA hsa-miR-140-5p CUEDC1 -0.755971041589807 9.68060922934542e-14 0.535243989773495 1.47667281345025e-07 PITA;miRanda -0.190338766507983 2.13890698970369e-08 NA NA NA hsa-miR-140-5p CXXC4 -0.755971041589807 9.68060922934542e-14 -0.348454370147505 0.0800945501479367 miRanda -0.132297143749825 0.0468117068070835 NA NA NA hsa-miR-140-5p CYB5D1 -0.755971041589807 9.68060922934542e-14 -0.144322804183489 0.0757109919493837 miRanda -0.147453725957205 4.29587473558267e-08 NA NA NA hsa-miR-194-5p CYP26B1 0.467781870340114 1.0386810618625e-07 -2.18251820929743 2.06650075366595e-36 mirMAP -0.169515351025559 0.0163722796903637 NA NA NA hsa-miR-140-5p CYTH2 -0.755971041589807 9.68060922934542e-14 0.702575167222823 2.04335535926724e-21 MirTarget;miRanda;miRNATAP -0.268952561791146 4.00673013904369e-28 NA NA NA hsa-miR-194-5p CYTH3 0.467781870340114 1.0386810618625e-07 -0.739339936855419 6.60636378987249e-16 mirMAP -0.150089786025638 3.3316967329032e-05 NA NA NA hsa-miR-194-5p DAAM1 0.467781870340114 1.0386810618625e-07 -0.82527787657938 1.6912841517564e-12 miRNATAP -0.189174045503208 3.95432785140071e-05 NA NA NA hsa-miR-34a-5p DAPK2 0.129201805242403 0.133261654068224 -1.02689963252696 7.98595973064237e-21 MirTarget -0.103311672951104 0.022071212564172 27704360 E2F 1 promotes DAPK2 induced anti tumor immunity of gastric cancer cells by targeting miR 34a gastric cancer hsa-miR-194-5p DCBLD2 0.467781870340114 1.0386810618625e-07 -0.917133394406548 5.34724051251788e-23 MirTarget -0.201606303722395 4.71384653969331e-08 NA NA NA hsa-miR-140-5p DCDC1 -0.755971041589807 9.68060922934542e-14 0.957170707969865 5.32559319738306e-05 PITA;miRanda -0.520279203361886 3.52684417091482e-11 NA NA NA hsa-miR-140-5p DCDC2 -0.755971041589807 9.68060922934542e-14 -1.85592640035043 1.11259871848993e-09 miRanda -0.203582498769401 0.0477961444648824 NA NA NA hsa-miR-34a-5p DCX 0.129201805242403 0.133261654068224 -2.74666176017894 1.23860367619362e-14 MirTarget;miRNATAP -0.677910727957364 2.80286155979283e-06 NA NA NA hsa-miR-140-5p DHCR24 -0.755971041589807 9.68060922934542e-14 0.768977925816538 2.20099811362362e-09 miRanda -0.324148376438298 3.10022797293409e-14 NA NA NA hsa-miR-140-5p DHRS4L1 -0.755971041589807 9.68060922934542e-14 -0.0991231860873832 0.44302544820008 miRanda -0.211394164279017 8.24982064547619e-07 NA NA NA hsa-miR-194-5p DISC1 0.467781870340114 1.0386810618625e-07 -0.749733013619098 1.56009977071317e-15 MirTarget -0.133718142199019 0.000324356428076547 NA NA NA hsa-miR-34a-5p DLL1 0.129201805242403 0.133261654068224 -0.947678753705407 5.16495496029924e-14 miRNAWalker2_validate;miRTarBase;miRNATAP -0.184988188274597 0.000303752133199536 22438124 Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells lung squamous cell cancer hsa-miR-194-5p DMD 0.467781870340114 1.0386810618625e-07 -3.78348112804436 3.23742415858975e-92 MirTarget;miRNATAP -0.366303110396879 6.10888815673254e-06 NA NA NA hsa-miR-152-3p DMPK -0.26603867075042 0.0063861560676033 0.317567440048527 0.00201547517345691 MirTarget -0.163166186657419 6.48090423914157e-06 NA NA NA hsa-miR-140-5p DNAH14 -0.755971041589807 9.68060922934542e-14 1.80033769565743 2.95550762800763e-63 miRanda -0.21301334129501 3.16080524401656e-08 NA NA NA hsa-miR-140-5p DNAH7 -0.755971041589807 9.68060922934542e-14 -0.380562206375501 0.0511018111833808 miRanda -0.317644024570308 9.6320148080663e-07 NA NA NA hsa-miR-140-5p DNAJA4 -0.755971041589807 9.68060922934542e-14 0.778974960199304 3.35701271270575e-11 miRanda -0.215919933177555 4.32405766929061e-08 NA NA NA hsa-miR-140-5p DNMBP -0.755971041589807 9.68060922934542e-14 -0.666936518001947 1.27257555078449e-08 miRanda -0.100223297452939 0.011109832177499 NA NA NA hsa-miR-152-3p DNMT1 -0.26603867075042 0.0063861560676033 1.03734724658835 1.1672911519669e-42 miRNAWalker2_validate;miRTarBase;MirTarget -0.161018321479129 8.27043261873361e-09 27475839;21868754;25004396;20578129;24998573;23318422 mRNA and protein expression profile of DNMT1 implicate that miR-152 targets DNMT1 mRNA and inhibits its protein expression; Further experiments revealed that DNMT1 plays crucial role for regulation of miR-152 gene; When DNMT1 protein function is blocked miR-152 expression prevails and destroys the mRNA of DNMT1; this molecular regulatory mechanism is creating a cyclic feedback loop which is now focused as DNMT1/miR-152 switch for on/off of DNMT1 target genes; We have demonstrated further that DNMT1 down regulation mediated upregulation of CDH1 hereafter DNMT1/CDH1 loop in presence of ectopic-excess of miR-152 prevents migration of cancer cells;Epigenetic silencing documented in miR-152 was consistent with its location at 17q21.32 in intron 1 of the COPZ2 gene which is also silenced often in endometrial cancer by DNA hypermethylation and also with evidence that miR-152 targets the DNA methyltransferase DNMT1;There appeared to be a reciprocal regulatory relationship of miR-152/DNMT1 expression as cells treated with siRNA DNMT1 caused miR-152 to be re-expressed in all cell lines;Our results showed that the expression of microRNA-152 miR-152 was frequently down-regulated in HBV-related HCC tissues in comparison with adjacent noncancerous hepatic tissues and was inversely correlated to DNA methyltransferase 1 DNMT1 messenger RNA mRNA expression in HBV-related HCCs; The forced expression of miR-152 in liver cell lines resulted in a marked reduction of the expression of DNMT1 at both the mRNA and protein levels by directly targeting the 3' untranslated regions of DNMT1; Our findings suggest that miR-152 is frequently down-regulated and regulates DNMT1 in HBV-related HCC;Furthermore Western blotting showed that the miR-152 mimic downregulated Wnt-1 DNMT1 ERK1/2 AKT and TNFRS6B signaling;MiR 152 and miR 185 co contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine; The overexpression of miR-152 or miR-185 increased cisplatin sensitivity of SKOV3/DDP and A2780/DDP cells by inhibiting proliferation and promoting apoptosis then we further confirmed that these miRNAs functioned through suppressing DNA methyltransferase 1 DNMT1 directly; Our results indicated that miR-152 and miR-185 were involved in ovarian cancer cisplatin resistance in vitro and in vivo by targeting DNMT1 directly ;;;;;drug resistance breast cancer;endometrial cancer;prostate cancer;liver cancer;liver cancer;ovarian cancer hsa-miR-140-5p DNPEP -0.755971041589807 9.68060922934542e-14 0.471519729362952 5.57428314365212e-15 miRNAWalker2_validate;miRTarBase -0.160140880983574 1.67857814594697e-15 NA NA NA hsa-miR-140-5p DPP9 -0.755971041589807 9.68060922934542e-14 0.83627581064848 5.73562748012033e-37 miRanda -0.190222792191214 3.24884991038211e-17 NA NA NA hsa-miR-140-5p DUSP16 -0.755971041589807 9.68060922934542e-14 -0.00309802634061906 0.972233283825713 miRNATAP -0.169799719646446 7.99001714099057e-09 NA NA NA hsa-miR-140-5p EARS2 -0.755971041589807 9.68060922934542e-14 0.690216363319825 1.6375863352301e-24 miRanda -0.197485592642628 3.65000077662871e-18 NA NA NA hsa-miR-140-5p ECHDC2 -0.755971041589807 9.68060922934542e-14 -0.578797868053678 4.7271743964137e-08 miRanda -0.156868566080825 1.00192381063834e-05 NA NA NA hsa-miR-140-5p ECM1 -0.755971041589807 9.68060922934542e-14 1.09554661761308 1.23280400578586e-08 miRanda -0.309330823683822 1.61390609676957e-06 NA NA NA hsa-miR-34a-5p EDAR 0.129201805242403 0.133261654068224 -2.78657132772223 2.4195664655362e-25 miRNATAP -0.45630012879257 3.66299418319983e-05 NA NA NA hsa-miR-194-5p EDN1 0.467781870340114 1.0386810618625e-07 -1.72115310703749 1.9106679470357e-25 MirTarget;miRNATAP -0.223950699903522 0.000722595931673068 NA NA NA hsa-miR-140-5p EFCAB2 -0.755971041589807 9.68060922934542e-14 -0.080135227138169 0.438416947959067 miRanda -0.142115284807655 3.57567337177234e-05 NA NA NA hsa-miR-140-5p EFHC2 -0.755971041589807 9.68060922934542e-14 0.349216509359692 0.0867559731479253 miRanda -0.17545982192607 0.00997269252629183 NA NA NA hsa-miR-140-5p EFNA4 -0.755971041589807 9.68060922934542e-14 1.36555460859862 9.20640991197574e-28 PITA;miRanda -0.167870909172277 9.74014850651836e-05 NA NA NA hsa-miR-34a-5p EFNB3 0.129201805242403 0.133261654068224 -1.46127308517026 6.88852125012967e-17 miRNATAP -0.219660735842772 0.00214695851967333 NA NA NA hsa-miR-140-5p EFR3B -0.755971041589807 9.68060922934542e-14 0.730193640676275 4.13434721202402e-06 miRanda -0.140872786266578 0.00813636036386753 NA NA NA hsa-miR-140-5p EGLN3 -0.755971041589807 9.68060922934542e-14 1.25406110119931 1.58374008569191e-13 miRanda -0.310369623246908 5.83542572064473e-08 NA NA NA hsa-miR-194-5p EGR2 0.467781870340114 1.0386810618625e-07 -2.23233044425839 1.40886014268655e-41 miRNATAP -0.25877265315914 0.00013100242887546 NA NA NA hsa-miR-194-5p EHBP1 0.467781870340114 1.0386810618625e-07 -1.25365375049079 3.47077158792021e-60 MirTarget;miRNATAP -0.121176036755453 0.000159654871715302 NA NA NA hsa-miR-140-5p EHMT2 -0.755971041589807 9.68060922934542e-14 0.758244285222948 1.73646695394332e-30 miRanda -0.133061843360899 4.41761277343697e-09 NA NA NA hsa-miR-194-5p EIF4E3 0.467781870340114 1.0386810618625e-07 -1.14472452087938 6.75636040536301e-35 miRNATAP -0.109996510556975 0.00355987207090832 NA NA NA hsa-miR-194-5p ELF1 0.467781870340114 1.0386810618625e-07 -0.23480619633058 0.00413618257171506 miRNAWalker2_validate -0.111564612215178 0.000461731438979504 NA NA NA hsa-miR-140-5p ELOVL2 -0.755971041589807 9.68060922934542e-14 0.225102608780354 0.467284175330234 miRanda -0.406756173990623 7.9582916429524e-05 NA NA NA hsa-miR-140-5p ELOVL5 -0.755971041589807 9.68060922934542e-14 -0.303052367414431 0.0214705661280659 miRanda -0.141834374450366 0.00125915380158413 NA NA NA hsa-miR-194-5p EMCN 0.467781870340114 1.0386810618625e-07 -2.14933728794567 9.07812000902704e-62 MirTarget -0.365051578803016 1.32683829151581e-11 NA NA NA hsa-miR-140-5p ENOSF1 -0.755971041589807 9.68060922934542e-14 -0.0494377033754967 0.530975780572447 miRanda -0.102600723897258 9.15858936038284e-05 NA NA NA hsa-miR-140-5p ENPP5 -0.755971041589807 9.68060922934542e-14 0.730179563987445 0.000250569116717678 miRanda -0.374750115328182 1.58702417486631e-08 NA NA NA hsa-miR-140-5p ENSA -0.755971041589807 9.68060922934542e-14 0.722997516483187 1.48399679519323e-27 PITA -0.180684482114514 1.05391470035401e-15 NA NA NA hsa-miR-140-5p ENTPD5 -0.755971041589807 9.68060922934542e-14 -0.337003547382125 0.0159602342643349 MirTarget;miRanda -0.150290024337852 0.00128341092155749 NA NA NA hsa-miR-34a-5p EPB41L2 0.129201805242403 0.133261654068224 -1.76480491649636 1.15237907583462e-57 miRNAWalker2_validate -0.179456739687866 0.000156339363206854 NA NA NA hsa-miR-140-5p EPB41L4A -0.755971041589807 9.68060922934542e-14 -0.674310150249758 9.72635451687197e-08 miRanda -0.140361460253783 0.000953756159142461 NA NA NA hsa-miR-194-5p EPHA3 0.467781870340114 1.0386810618625e-07 -0.830979412970837 4.29268925743742e-05 miRNATAP -0.450337201271557 1.12210272794804e-08 NA NA NA hsa-miR-34a-5p EPHA4 0.129201805242403 0.133261654068224 -1.55269305526411 1.14762781890163e-27 miRNATAP -0.152603351130788 0.00984692330091796 NA NA NA hsa-miR-140-5p EPN2 -0.755971041589807 9.68060922934542e-14 -0.0264754384448693 0.695378898008471 miRanda -0.116931781801506 1.74146202009919e-07 NA NA NA hsa-miR-140-5p ERBB4 -0.755971041589807 9.68060922934542e-14 -0.949260076610313 0.006124970228615 PITA -0.683275679037952 2.69850298884891e-09 NA NA NA hsa-miR-194-5p ERBB4 0.467781870340114 1.0386810618625e-07 -0.949260076610313 0.006124970228615 miRNATAP -0.275670223439778 0.0415000023578523 NA NA NA hsa-miR-34a-5p ERC1 0.129201805242403 0.133261654068224 -0.360248736264644 4.26949272667695e-07 mirMAP;miRNATAP -0.145133180353668 3.7825165506858e-07 NA NA NA hsa-miR-194-5p ERG 0.467781870340114 1.0386810618625e-07 -1.79406293965654 1.24967833223395e-59 MirTarget -0.326892536026112 8.05940658788518e-13 NA NA NA hsa-miR-140-5p ERI2 -0.755971041589807 9.68060922934542e-14 0.367887024257485 6.00654283242427e-06 miRanda -0.197015232842123 2.28491647458418e-13 NA NA NA hsa-miR-34a-5p EVC 0.129201805242403 0.133261654068224 -0.696684919412769 3.38576866916321e-10 mirMAP -0.109718822282259 0.0147356561413346 NA NA NA hsa-miR-140-5p EVPL -0.755971041589807 9.68060922934542e-14 2.22141096208917 8.97201365613739e-50 miRanda -0.414957231017984 2.30968351277902e-15 NA NA NA hsa-miR-194-5p EXOC5 0.467781870340114 1.0386810618625e-07 -0.249132289068914 0.000144654237672916 MirTarget;miRNATAP -0.103345391558622 5.06082326334216e-05 NA NA NA hsa-miR-140-5p EXOC6 -0.755971041589807 9.68060922934542e-14 0.307205555860763 0.000882348548359484 miRanda -0.200031766185007 5.98784683964223e-11 NA NA NA hsa-miR-194-5p EYA4 0.467781870340114 1.0386810618625e-07 -1.70735688835573 6.25677946773534e-11 miRNATAP -0.548727016203469 8.11943615483431e-08 NA NA NA hsa-miR-34a-5p F2RL2 0.129201805242403 0.133261654068224 1.83288694519631 1.27552904921777e-14 MirTarget;miRNATAP -0.273962671456491 0.00473709403031966 NA NA NA hsa-miR-140-5p FAHD1 -0.755971041589807 9.68060922934542e-14 0.778155825824243 6.70403995205136e-28 miRanda -0.188022817727868 6.59247187063183e-15 NA NA NA hsa-miR-140-5p FAM102A -0.755971041589807 9.68060922934542e-14 1.23639689570928 1.94284110814203e-47 PITA;miRanda;miRNATAP -0.308177693725295 8.99362377903089e-26 NA NA NA hsa-miR-34a-5p FAM117B 0.129201805242403 0.133261654068224 0.0604096747081551 0.39180010839393 MirTarget -0.130922910879068 3.21697282063869e-06 NA NA NA hsa-miR-140-5p FAM134A -0.755971041589807 9.68060922934542e-14 0.255551735024426 1.95676542883366e-07 miRanda -0.10072751512678 6.42133230038013e-10 NA NA NA hsa-miR-194-5p FAM160B1 0.467781870340114 1.0386810618625e-07 -0.617695385113071 7.35235824201269e-22 miRNATAP -0.105718764011151 3.56966883447576e-05 NA NA NA hsa-miR-34a-5p FAM168A 0.129201805242403 0.133261654068224 -0.595647286022841 1.59492655064768e-06 mirMAP -0.190220225413009 0.000141052431104075 NA NA NA hsa-miR-140-5p FAM189A1 -0.755971041589807 9.68060922934542e-14 0.339750291294292 0.199307555843452 miRanda -0.231525063408977 0.00879502423922774 NA NA NA hsa-miR-34a-5p FAM53B 0.129201805242403 0.133261654068224 0.268092446059919 0.00126200740360576 mirMAP -0.159237445795523 1.66425721694019e-06 NA NA NA hsa-miR-194-5p FAM63B 0.467781870340114 1.0386810618625e-07 -1.04324614957652 4.45317569057325e-13 miRNATAP -0.186526281001754 0.00103884480575197 NA NA NA hsa-miR-34a-5p FAT3 0.129201805242403 0.133261654068224 -1.39927804148844 8.16110526253237e-11 miRNATAP -0.184590017486928 0.0348852794089329 NA NA NA hsa-miR-34a-5p FAT4 0.129201805242403 0.133261654068224 -2.33360300758631 3.89695808711231e-45 MirTarget -0.354502862980423 3.95531561333971e-07 NA NA NA hsa-miR-34a-5p FIGN 0.129201805242403 0.133261654068224 -2.43971791427329 1.33964701286684e-33 miRNAWalker2_validate -0.203210028809886 0.016206486232265 NA NA NA hsa-miR-140-5p FKBP10 -0.755971041589807 9.68060922934542e-14 1.22438203360277 6.3812849932254e-29 miRanda -0.276035413972743 1.59952615325915e-13 NA NA NA hsa-miR-140-5p FKBP4 -0.755971041589807 9.68060922934542e-14 1.51649518800158 5.45998827527614e-51 miRanda;miRNATAP -0.357537744115052 1.31021029207117e-24 NA NA NA hsa-miR-194-5p FLI1 0.467781870340114 1.0386810618625e-07 -1.26235715548629 4.88985347259214e-39 MirTarget -0.1891990357316 1.46494926235005e-06 NA NA NA hsa-miR-152-3p FLOT2 -0.26603867075042 0.0063861560676033 0.0891303697170871 0.182806621413572 MirTarget -0.106951957839949 5.08464020158104e-06 NA NA NA hsa-miR-140-5p FLVCR1 -0.755971041589807 9.68060922934542e-14 1.30642131036125 5.63542955422088e-36 miRanda -0.161410937548979 8.58068931313503e-06 NA NA NA hsa-miR-140-5p FNIP1 -0.755971041589807 9.68060922934542e-14 -0.243201740782599 0.00276888300557918 miRanda -0.101623761429349 0.000176471508118765 NA NA NA hsa-miR-34a-5p FOXK1 0.129201805242403 0.133261654068224 -0.349044780616968 7.57441065964192e-06 mirMAP -0.108150934072414 0.000562305987891919 NA NA NA hsa-miR-34a-5p FOXN3 0.129201805242403 0.133261654068224 -1.6997111136462 5.59981199956681e-76 miRNATAP -0.187958471703313 3.48422336957395e-06 NA NA NA hsa-miR-194-5p FOXO1 0.467781870340114 1.0386810618625e-07 -1.98726551876693 3.0579805549685e-75 miRNATAP -0.30557204301566 2.69636984990517e-11 24631529 Gα12gep oncogene inhibits FOXO1 in hepatocellular carcinoma as a consequence of miR 135b and miR 194 dysregulation; In addition Gα12QL repressed miR-194 cluster gene products 194/192/215 which contributed to MDM2-mediated FOXO1 repression; Moreover decrease of FOXO1 or miR-194 was statistically significant between stages T1 and T2 whereas increase of miR-135b discriminated tumor stage T3a versus T1/T2 staging liver cancer hsa-miR-194-5p FOXP2 0.467781870340114 1.0386810618625e-07 -3.10671503377831 7.7457852611569e-43 miRNATAP -0.51651468708469 2.28839313939756e-08 NA NA NA hsa-miR-140-5p FRS2 -0.755971041589807 9.68060922934542e-14 -0.151534815530378 0.172700768380748 PITA;miRanda -0.107851545105383 0.0036120022188424 NA NA NA hsa-miR-140-5p FSTL4 -0.755971041589807 9.68060922934542e-14 1.62107563529826 2.13575370330569e-11 miRanda -0.583227394629844 5.15301888464311e-13 NA NA NA hsa-miR-194-5p FZD5 0.467781870340114 1.0386810618625e-07 -1.30576854554188 8.3393662705584e-32 miRNATAP -0.178831539257334 6.90395730167637e-05 NA NA NA hsa-miR-194-5p FZD6 0.467781870340114 1.0386810618625e-07 -0.245458286479777 0.0729026487995083 MirTarget -0.1574113672057 0.003131819177647 NA NA NA hsa-miR-140-5p GALNT6 -0.755971041589807 9.68060922934542e-14 1.53253468503729 1.95615996419132e-15 miRanda -0.709250671946961 4.16569926266848e-29 NA NA NA hsa-miR-194-5p GAS7 0.467781870340114 1.0386810618625e-07 -1.14456976255473 3.24757711318389e-18 mirMAP -0.21910592761129 2.66110740331343e-05 NA NA NA hsa-miR-140-5p GAS8 -0.755971041589807 9.68060922934542e-14 0.324378523367666 2.80214638396508e-05 miRanda -0.113486637928806 1.12137978710208e-05 NA NA NA hsa-miR-140-5p GATA3 -0.755971041589807 9.68060922934542e-14 1.5576496597582 2.58751948867418e-11 PITA;miRanda -0.907360761593115 6.09337982303211e-33 NA NA NA hsa-miR-140-5p GCM1 -0.755971041589807 9.68060922934542e-14 0.360191323603245 0.134565410281452 miRanda -0.334262634880811 3.02257256895128e-05 NA NA NA hsa-miR-140-5p GDE1 -0.755971041589807 9.68060922934542e-14 0.345346647212217 2.60816934857472e-08 miRanda -0.135848518681727 4.43169511730756e-11 NA NA NA hsa-miR-34a-5p GDPD5 0.129201805242403 0.133261654068224 -1.42259476027658 2.71926623796958e-27 mirMAP -0.129883733557081 0.0172594516570271 NA NA NA hsa-miR-34a-5p GFRA1 0.129201805242403 0.133261654068224 -0.692412159332901 0.064695425447951 miRNATAP -0.661941166368614 1.00749540653096e-05 NA NA NA hsa-miR-140-5p GIGYF1 -0.755971041589807 9.68060922934542e-14 0.125800039901468 0.125564353932774 miRanda -0.160847511810051 3.16549508521594e-09 NA NA NA hsa-miR-140-5p GINS1 -0.755971041589807 9.68060922934542e-14 2.30840426465024 1.57569372974694e-71 MirTarget;miRanda -0.111786038287838 0.0178585943126129 NA NA NA hsa-miR-140-5p GLI3 -0.755971041589807 9.68060922934542e-14 -0.342784298215017 0.0107211036407835 PITA;miRanda -0.281189182006381 2.53455553334543e-10 NA NA NA hsa-miR-194-5p GLIS3 0.467781870340114 1.0386810618625e-07 0.200467275886753 0.173179262210237 miRNATAP -0.163687947666252 0.00427080361561159 NA NA NA hsa-miR-140-5p GLRX5 -0.755971041589807 9.68060922934542e-14 0.414786118695306 1.36010684976478e-11 miRanda;miRNATAP -0.134814540580673 4.52557652514019e-11 NA NA NA hsa-miR-140-5p GLS2 -0.755971041589807 9.68060922934542e-14 0.13783107812589 0.438151405215952 miRanda -0.358093563511269 1.12505124633692e-09 NA NA NA hsa-miR-140-5p GLUL -0.755971041589807 9.68060922934542e-14 0.0939365968380947 0.393446776945062 miRanda -0.1868947746155 3.05698310579172e-07 NA NA NA hsa-miR-140-5p GNPTG -0.755971041589807 9.68060922934542e-14 0.444930924423057 6.0106437744241e-08 miRanda -0.222650247543753 2.17676165416859e-16 NA NA NA hsa-miR-140-5p GPD1L -0.755971041589807 9.68060922934542e-14 -0.937731331711184 4.68433443761075e-16 miRanda -0.140951707917334 0.000323153195639316 NA NA NA hsa-miR-194-5p GPM6B 0.467781870340114 1.0386810618625e-07 -2.23343254430802 1.51570824751064e-39 miRNATAP -0.219807806734616 0.0015389302054939 NA NA NA hsa-miR-34a-5p GPR156 0.129201805242403 0.133261654068224 -0.926380335525025 2.77393738091549e-05 MirTarget -0.192265358661685 0.0310317570172907 NA NA NA hsa-miR-34a-5p GREM2 0.129201805242403 0.133261654068224 -2.65211306689938 8.60704393228989e-30 MirTarget;miRNATAP -0.19613198018317 0.0442019730288402 NA NA NA hsa-miR-34a-5p GRID1 0.129201805242403 0.133261654068224 -1.26594797560263 4.62889296276057e-22 miRNATAP -0.230596744736542 1.83247523511362e-05 NA NA NA hsa-miR-140-5p GRIK4 -0.755971041589807 9.68060922934542e-14 0.897296904823413 0.000510899507719862 miRanda -0.618900932656308 4.03575337335848e-13 NA NA NA hsa-miR-140-5p GRIPAP1 -0.755971041589807 9.68060922934542e-14 0.580856462625689 3.8171303617203e-20 miRanda -0.146664449612761 5.82055485139559e-12 NA NA NA hsa-miR-194-5p HBEGF 0.467781870340114 1.0386810618625e-07 -1.07492699127294 1.02818888149412e-20 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.133692970111692 0.00361495780952298 NA NA NA hsa-miR-140-5p HDAC7 -0.755971041589807 9.68060922934542e-14 -0.100564030391284 0.103880800546895 miRanda;miRNATAP -0.148253045343563 2.94203458138286e-13 NA NA NA hsa-miR-140-5p HDC -0.755971041589807 9.68060922934542e-14 -0.965729427865039 0.00010852058933711 miRanda -0.364109664094581 1.2424577485736e-05 NA NA NA hsa-miR-34a-5p HIC2 0.129201805242403 0.133261654068224 -0.30171087568962 2.68519567970826e-05 mirMAP -0.124367007974165 1.58611723413437e-05 NA NA NA hsa-miR-34a-5p HIPK2 0.129201805242403 0.133261654068224 -0.953765945586234 3.35720241682395e-14 mirMAP -0.163108295086776 0.00144966864946411 NA NA NA hsa-miR-152-3p HLA-G -0.26603867075042 0.0063861560676033 0.475681400959062 0.0143687808562262 miRNAWalker2_validate;miRTarBase -0.193381275308844 0.00481028341975201 26187665;26627200 Long non coding RNA HOTAIR promotes HLA G expression via inhibiting miR 152 in gastric cancer cells; On the other hand bioinformatics analysis indicated the interaction between HOTAIR and miR-152 which shows potential regulation on HLA-G; Therefore it was concluded that HOTAIR overexpression might also get involved in tumor escape mechanisms involving HLA-G upregulation via inhibiting miR-152;TGF β induces HLA G expression through inhibiting miR 152 in gastric cancer cells; This study aims to verify the correlations between HLA-G and TGF-β involving the potential targeting of miR-152 on HLA-G; Furthermore miR-152 expression could be inhibited by TGF-β and the negative post-transcriptionally regulation of miR-152 on HLA-G was also demonstrated through gain- and loss-of-function studies; Besides miR-152 overexpression repressed HLA-G up-regulation induced by TGF-β; And miR-152 expression levels showed inversely proportional to both HLA-G and also TGF-β levels in GC patients; TGF-β could induce HLA-G expression in GC by inhibiting miR-152 involving its negative regulation on HLA-G; Since TGF-β induced HLA-G up-regulation plays important role in immune escape a potential application of miR-152 was suggested in GC treatment or miR-152 might be one potential biomarker for GC ; gastric cancer;gastric cancer hsa-miR-140-5p HMGCL -0.755971041589807 9.68060922934542e-14 0.119677157715048 0.0987034936096925 miRanda -0.14456131834383 1.58232318942636e-09 NA NA NA hsa-miR-140-5p HMGN1 -0.755971041589807 9.68060922934542e-14 0.99357721854444 1.08962931509182e-48 miRanda -0.126056012951725 1.27702534569232e-07 NA NA NA hsa-miR-140-5p HNRNPM -0.755971041589807 9.68060922934542e-14 0.544682020837556 1.57506336505434e-31 miRanda -0.115960180320968 3.0392037608375e-13 NA NA NA hsa-miR-140-5p HOMEZ -0.755971041589807 9.68060922934542e-14 0.249030288632344 0.000534539881875597 miRanda -0.19108973977148 6.08038230868351e-16 NA NA NA hsa-miR-140-5p HOPX -0.755971041589807 9.68060922934542e-14 1.11609867489533 1.48157161168801e-18 miRanda -0.139529929329016 0.0012610524463207 NA NA NA hsa-miR-140-5p HOXB3 -0.755971041589807 9.68060922934542e-14 -0.0860590412997158 0.642417857654296 miRanda -0.338527966396212 3.54353564021181e-08 NA NA NA hsa-miR-194-5p HS3ST2 0.467781870340114 1.0386810618625e-07 -0.550148429430354 0.00226309573685005 MirTarget;miRNATAP -0.340131949185687 1.16933702348251e-06 NA NA NA hsa-miR-140-5p IGF1R -0.755971041589807 9.68060922934542e-14 0.118209603036572 0.482168850037006 PITA;miRNATAP -0.148653480588664 0.0080741246036404 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-34a-5p IGF2 0.129201805242403 0.133261654068224 -1.80707502143834 9.64580354953106e-21 mirMAP -0.242484753846277 0.00229621728593982 NA NA NA hsa-miR-140-5p IGFBP2 -0.755971041589807 9.68060922934542e-14 0.596935721060786 0.00109631938043027 miRanda -0.406733662323868 1.79767000222464e-11 NA NA NA hsa-miR-34a-5p IGFBP5 0.129201805242403 0.133261654068224 -0.624288440197653 0.00100115978565398 mirMAP -0.17302633015973 0.0234603470026858 NA NA NA hsa-miR-140-5p IGSF3 -0.755971041589807 9.68060922934542e-14 0.889266392741621 3.34886421336615e-15 MirTarget;PITA;miRanda;miRNATAP -0.111393094781598 0.00365025041378782 NA NA NA hsa-miR-34a-5p IGSF3 0.129201805242403 0.133261654068224 0.889266392741621 3.34886421336615e-15 MirTarget -0.100778847922227 0.0288177663105811 NA NA NA hsa-miR-140-5p IKBKG -0.755971041589807 9.68060922934542e-14 0.490716396303581 1.1441359682473e-11 miRanda -0.125852887257061 2.14634764656029e-07 NA NA NA hsa-miR-140-5p IL11 -0.755971041589807 9.68060922934542e-14 2.04832143954671 4.97278137496706e-38 miRanda -0.285248202520413 2.49619873242136e-07 NA NA NA hsa-miR-34a-5p ING5 0.129201805242403 0.133261654068224 -0.237265481897531 0.000243359848640052 mirMAP -0.100801887813945 0.000100097080391815 NA NA NA hsa-miR-140-5p IPPK -0.755971041589807 9.68060922934542e-14 0.757950965701765 3.20055961654039e-31 miRanda -0.134331699992864 1.99314586216557e-09 NA NA NA hsa-miR-140-5p IQCE -0.755971041589807 9.68060922934542e-14 0.738559609175382 4.11450157120893e-24 mirMAP -0.197989159173803 8.5450208800539e-16 NA NA NA hsa-miR-140-5p IQCH -0.755971041589807 9.68060922934542e-14 0.319473601577162 0.00965083451467473 miRanda -0.281098052128335 5.32321706238544e-12 NA NA NA hsa-miR-194-5p ITGA9 0.467781870340114 1.0386810618625e-07 -1.80608575406488 8.11052269984858e-33 miRNAWalker2_validate;miRTarBase -0.121622903135256 0.0478148056330908 NA NA NA hsa-miR-152-3p ITPK1 -0.26603867075042 0.0063861560676033 -0.0622341021457355 0.47674637322623 MirTarget -0.113759111633887 0.000214508331784692 NA NA NA hsa-miR-34a-5p ITPR2 0.129201805242403 0.133261654068224 -0.979435994319307 6.70245773649528e-14 MirTarget -0.181215796033106 0.000656619695493269 NA NA NA hsa-miR-34a-5p ITSN1 0.129201805242403 0.133261654068224 -1.54952456784757 2.98389839982187e-72 mirMAP -0.120412856845002 0.00146044818350177 NA NA NA hsa-miR-140-5p IYD -0.755971041589807 9.68060922934542e-14 1.0768314494353 0.00194895475806759 miRanda -0.519727656365832 7.27994749709653e-06 NA NA NA hsa-miR-34a-5p JAG1 0.129201805242403 0.133261654068224 -0.639848689982383 1.267264807356e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.109741827165887 0.00421467997130295 NA NA NA hsa-miR-152-3p JARID2 -0.26603867075042 0.0063861560676033 0.581004002397887 3.75615851610388e-17 MirTarget -0.107578151894443 1.32368926134523e-05 NA NA NA hsa-miR-194-5p JKAMP 0.467781870340114 1.0386810618625e-07 0.0735788909422048 0.22789285081931 MirTarget -0.111388368392485 2.34456878669748e-06 NA NA NA hsa-miR-194-5p KCNA1 0.467781870340114 1.0386810618625e-07 -2.92558361314474 6.5800868813974e-30 mirMAP -0.343773290660211 0.000944593744060597 NA NA NA hsa-miR-34a-5p KCNA1 0.129201805242403 0.133261654068224 -2.92558361314474 6.5800868813974e-30 miRNATAP -0.592000158273979 2.69700972123137e-08 NA NA NA hsa-miR-140-5p KCNC1 -0.755971041589807 9.68060922934542e-14 -0.419819323532828 0.125779819998908 miRanda -0.311877075352497 0.000647887173871117 NA NA NA hsa-miR-140-5p KCNJ3 -0.755971041589807 9.68060922934542e-14 1.14360888985924 0.0214898774529532 miRanda -0.725191554383511 1.19782718296441e-05 NA NA NA hsa-miR-140-5p KCNK6 -0.755971041589807 9.68060922934542e-14 1.29506663214078 1.20540250468269e-23 miRanda -0.376675196803402 4.76162356865804e-18 NA NA NA hsa-miR-34a-5p KCNQ4 0.129201805242403 0.133261654068224 -2.00601887339821 2.87129859849754e-16 mirMAP -0.313373896411856 0.00176720005825768 NA NA NA hsa-miR-140-5p KCTD11 -0.755971041589807 9.68060922934542e-14 0.112799443305112 0.0722652677405418 miRanda -0.115276154664333 2.81440798514923e-08 NA NA NA hsa-miR-194-5p KCTD20 0.467781870340114 1.0386810618625e-07 -0.522937645404041 1.61102511851964e-09 MirTarget -0.125762995022629 0.000216234199894563 NA NA NA hsa-miR-140-5p KCTD3 -0.755971041589807 9.68060922934542e-14 0.419695559659947 4.46591182260529e-05 miRanda -0.212567675304362 4.69984949766279e-10 NA NA NA hsa-miR-140-5p KIAA0040 -0.755971041589807 9.68060922934542e-14 0.367039522069309 0.00180529927334225 MirTarget;miRanda -0.235081757464257 1.65908920838307e-09 NA NA NA hsa-miR-194-5p KIAA1210 0.467781870340114 1.0386810618625e-07 -0.746964624841095 0.00136637318101393 MirTarget -0.211013732166573 0.020589665332163 NA NA NA hsa-miR-34a-5p KIAA1462 0.129201805242403 0.133261654068224 -0.894733095554471 4.07536183567301e-18 MirTarget -0.128596684929979 0.00231551614145778 NA NA NA hsa-miR-194-5p KIAA1644 0.467781870340114 1.0386810618625e-07 1.06971961713243 5.04812834911815e-08 mirMAP -0.27049222495043 0.000439529204899993 NA NA NA hsa-miR-152-3p KIF14 -0.26603867075042 0.0063861560676033 3.70866385419027 4.23488636355338e-76 MirTarget -0.158546743778654 0.0423582447970375 NA NA NA hsa-miR-140-5p KIF3A -0.755971041589807 9.68060922934542e-14 0.216652608215624 0.0117121874159282 miRanda -0.137275804123834 1.53609544571776e-06 NA NA NA hsa-miR-140-5p KIF4A -0.755971041589807 9.68060922934542e-14 4.43931190902373 8.06469589311404e-121 miRanda -0.230991974650064 0.00173836873764651 NA NA NA hsa-miR-34a-5p KIT 0.129201805242403 0.133261654068224 -3.55980779277124 2.17700605158782e-58 MirTarget -0.444920568628705 2.86104030251141e-06 NA NA NA hsa-miR-34a-5p KITLG 0.129201805242403 0.133261654068224 -0.144677358802896 0.348643719752218 MirTarget -0.193013612056888 0.00180458841369172 NA NA NA hsa-miR-34a-5p KLB 0.129201805242403 0.133261654068224 -4.39501154494066 7.99875073016999e-95 miRNAWalker2_validate;miRTarBase -0.22882007040995 0.0174830170912026 NA NA NA hsa-miR-34a-5p KLF13 0.129201805242403 0.133261654068224 -0.896526705579424 4.61689653388107e-25 mirMAP -0.132063949879385 0.000221408209408011 NA NA NA hsa-miR-34a-5p KLF4 0.129201805242403 0.133261654068224 -2.5658507723861 1.98241408884064e-67 MirTarget;miRNATAP -0.158656084881947 0.0141218354001629 NA NA NA hsa-miR-194-5p KLF7 0.467781870340114 1.0386810618625e-07 -0.960860641075609 9.39965862664561e-13 miRNATAP -0.197465525495738 0.000197644969072455 NA NA NA hsa-miR-34a-5p KLF7 0.129201805242403 0.133261654068224 -0.960860641075609 9.39965862664561e-13 miRNATAP -0.157361355542325 0.00404647264448548 NA NA NA hsa-miR-194-5p KLHL11 0.467781870340114 1.0386810618625e-07 -0.637732961222202 0.000127158662509749 MirTarget -0.136627587422279 0.0358441552157651 NA NA NA hsa-miR-152-3p KLHL17 -0.26603867075042 0.0063861560676033 1.16090038848978 5.79495737750803e-27 MirTarget -0.29780716405694 1.49711593198175e-14 NA NA NA hsa-miR-140-5p KSR2 -0.755971041589807 9.68060922934542e-14 -0.0859402107200666 0.658608084265407 mirMAP -0.307784236594514 1.89212252886223e-06 NA NA NA hsa-miR-194-5p LANCL1 0.467781870340114 1.0386810618625e-07 -0.553726952789464 2.49149724458199e-16 MirTarget -0.100510695482452 0.000167993045463611 NA NA NA hsa-miR-194-5p LATS1 0.467781870340114 1.0386810618625e-07 -0.990266110404731 6.58107345321622e-13 miRNATAP -0.166602825917208 0.00219039330169264 NA NA NA hsa-miR-194-5p LGI1 0.467781870340114 1.0386810618625e-07 -2.19372584538264 2.04380263555319e-14 MirTarget;miRNATAP -0.300003514044975 0.00826708704068949 NA NA NA hsa-miR-34a-5p LGR4 0.129201805242403 0.133261654068224 -1.80154760191776 1.78479409180551e-31 MirTarget;miRNATAP -0.172246404445712 0.00746567112883859 NA NA NA hsa-miR-194-5p LHX6 0.467781870340114 1.0386810618625e-07 -1.95178533559281 6.99624188227914e-45 miRNATAP -0.175574385841465 0.00213322248020717 NA NA NA hsa-miR-140-5p LINGO4 -0.755971041589807 9.68060922934542e-14 0.118675822714101 0.555514967434949 miRanda -0.249347389407883 0.00019956605781726 NA NA NA hsa-miR-194-5p LNPEP 0.467781870340114 1.0386810618625e-07 -0.989631439347203 8.70205363760698e-12 mirMAP -0.154941224075084 0.00673917876645015 NA NA NA hsa-miR-140-5p LNX2 -0.755971041589807 9.68060922934542e-14 0.33101922442166 8.52119674719654e-05 miRanda -0.130610524614526 3.29712007431138e-06 NA NA NA hsa-miR-194-5p LPP 0.467781870340114 1.0386810618625e-07 -1.17035459588915 3.47523383485479e-19 mirMAP -0.158181463585727 0.0023689813352227 NA NA NA hsa-miR-140-5p LRBA -0.755971041589807 9.68060922934542e-14 0.322142018050458 0.00274814169043239 miRanda -0.208821618905703 4.81565934972967e-09 NA NA NA hsa-miR-194-5p LRCH2 0.467781870340114 1.0386810618625e-07 -1.81531257152895 1.63762941420744e-37 MirTarget -0.346686585736645 1.51951630745178e-09 NA NA NA hsa-miR-140-5p LRP2 -0.755971041589807 9.68060922934542e-14 -0.807564034442771 0.0466284114536984 miRanda -0.525422295305769 0.000102762270618446 NA NA NA hsa-miR-152-3p LRP2 -0.26603867075042 0.0063861560676033 -0.807564034442771 0.0466284114536984 MirTarget -0.601004411192425 2.56562307820223e-05 NA NA NA hsa-miR-140-5p LRP2BP -0.755971041589807 9.68060922934542e-14 -0.387270547341077 5.52106558448288e-05 miRanda -0.115164408598461 0.000335494507203001 NA NA NA hsa-miR-34a-5p LRP4 0.129201805242403 0.133261654068224 -1.80859309249455 1.72412102466362e-32 MirTarget -0.252583788665433 6.92692090709297e-05 NA NA NA hsa-miR-140-5p LRRC1 -0.755971041589807 9.68060922934542e-14 0.84534429051747 2.57363318268502e-25 miRanda -0.143907683315954 2.2631339563642e-07 NA NA NA hsa-miR-140-5p LRRC15 -0.755971041589807 9.68060922934542e-14 3.53392343171925 7.8456170163519e-53 miRanda -0.340745929925161 3.40278741694763e-05 NA NA NA hsa-miR-140-5p LRRC17 -0.755971041589807 9.68060922934542e-14 -0.526098447402457 0.00602617191344875 miRanda -0.190846222232831 0.00287182668752861 NA NA NA hsa-miR-34a-5p LRRC55 0.129201805242403 0.133261654068224 0.603661961522672 7.29925788586255e-05 MirTarget;miRNATAP -0.254801052927525 3.05179477936503e-05 NA NA NA hsa-miR-140-5p LSM14B -0.755971041589807 9.68060922934542e-14 0.882411641763935 1.20708753581714e-46 MirTarget;miRanda;miRNATAP -0.146538885388883 9.11548106936387e-12 NA NA NA hsa-miR-140-5p LYPD6 -0.755971041589807 9.68060922934542e-14 -0.911250846189553 0.000276581086647733 miRanda -0.360788698019849 1.6126644212639e-05 NA NA NA hsa-miR-194-5p MAF 0.467781870340114 1.0386810618625e-07 -1.16207333224511 7.05311108318644e-38 miRNATAP -0.214077412954548 4.75253378339725e-09 NA NA NA hsa-miR-152-3p MAF1 -0.26603867075042 0.0063861560676033 0.239141232353952 0.0010857552876981 MirTarget -0.121213890854874 2.43794385517881e-06 NA NA NA hsa-miR-34a-5p MAGI1 0.129201805242403 0.133261654068224 -1.26305301454899 4.04392522280675e-34 miRNAWalker2_validate -0.138169684057071 0.00143591501354134 NA NA NA hsa-miR-152-3p MAGIX -0.26603867075042 0.0063861560676033 1.45368341268656 5.55769198186677e-27 MirTarget -0.278704291800342 1.19045262045221e-08 NA NA NA hsa-miR-140-5p MAL2 -0.755971041589807 9.68060922934542e-14 1.46283694262068 7.6365311426135e-27 miRanda -0.210603280309804 6.97466587846185e-06 NA NA NA hsa-miR-194-5p MAP1B 0.467781870340114 1.0386810618625e-07 -1.55002312958356 5.26140421124211e-31 MirTarget -0.225969331035469 2.85211650238216e-05 NA NA NA hsa-miR-194-5p MAP2 0.467781870340114 1.0386810618625e-07 -1.48495084198261 2.62387512550646e-19 MirTarget;miRNATAP -0.199082960611726 0.00249232463253641 NA NA NA hsa-miR-140-5p MAP3K12 -0.755971041589807 9.68060922934542e-14 0.000401227302291751 0.99702138751066 miRanda -0.26660537661619 4.35275604188887e-14 NA NA NA hsa-miR-140-5p MAP7 -0.755971041589807 9.68060922934542e-14 0.942032423887889 7.94661641283741e-20 miRanda -0.177616868075113 4.24195441391761e-07 NA NA NA hsa-miR-140-5p MARVELD2 -0.755971041589807 9.68060922934542e-14 1.12359621955454 1.74234529410055e-20 miRanda -0.27231269003743 3.00304925075523e-11 NA NA NA hsa-miR-194-5p MBNL2 0.467781870340114 1.0386810618625e-07 -1.37379574443944 8.08248700954969e-39 miRNATAP -0.192299055385233 7.4272180925694e-06 NA NA NA hsa-miR-194-5p MBNL3 0.467781870340114 1.0386810618625e-07 -1.92990157111799 7.13881373145437e-25 mirMAP -0.150345673678037 0.0458623518340493 NA NA NA hsa-miR-34a-5p MBP 0.129201805242403 0.133261654068224 -1.05743986242831 1.70792931878289e-20 mirMAP -0.129122802466568 0.00582557560713221 NA NA NA hsa-miR-34a-5p MCTP1 0.129201805242403 0.133261654068224 -1.60151272020006 4.27309943958378e-26 miRNATAP -0.232973777542527 0.00020028830609678 NA NA NA hsa-miR-140-5p MDK -0.755971041589807 9.68060922934542e-14 1.41558026249022 3.39223068491076e-23 miRanda -0.270705131152911 2.61684973141013e-08 NA NA NA hsa-miR-152-3p MDM4 -0.26603867075042 0.0063861560676033 0.113166606771184 0.0960960367986367 MirTarget -0.125663304235708 1.27968538819022e-07 NA NA NA hsa-miR-140-5p MEAF6 -0.755971041589807 9.68060922934542e-14 0.519001676330906 7.23398728923416e-17 miRanda -0.140980399439074 1.50612916291537e-11 NA NA NA hsa-miR-194-5p MEF2C 0.467781870340114 1.0386810618625e-07 -1.3628193091141 3.63471865869307e-46 miRNATAP -0.239864455000625 8.16622655421491e-10 NA NA NA hsa-miR-140-5p MEF2D -0.755971041589807 9.68060922934542e-14 0.131564527494279 0.0295640483901206 PITA -0.137907649619689 4.28196224543177e-12 NA NA NA hsa-miR-140-5p MEGF9 -0.755971041589807 9.68060922934542e-14 -0.296058092250146 0.0106105936693003 miRanda -0.152302358027893 8.00162558241535e-05 NA NA NA hsa-miR-194-5p MEIS2 0.467781870340114 1.0386810618625e-07 -1.95002058092382 8.956929391428e-51 MirTarget;miRNATAP -0.267292470977658 6.56369418735903e-07 NA NA NA hsa-miR-34a-5p MET 0.129201805242403 0.133261654068224 -2.36906628256571 5.79970002931919e-38 miRNAWalker2_validate;miRTarBase -0.260533934700572 0.00074892552882336 23243217;26104764;22457788;23593387;19006648;19773441;19029026 Detection of miR 34a promoter methylation in combination with elevated expression of c Met and β catenin predicts distant metastasis of colon cancer; Using a case-control study design of 94 primary colon cancer samples with and without liver metastases we determined CpG methylation frequencies of miR-34a and miR-34b/c promoters expression of miR-34a and its targets c-Met Snail and β-catenin and their prognostic value; Decreased miR-34a expression was associated with upregulation of c-Met Snail and β-catenin protein levels P = 0.031 0.132 and 0.004 which were associated with distant metastases P = 0.001 0.017 and 0.005; In a confounder-adjusted multivariate regression model miR-34a methylation high c-Met and β-catenin levels provided the most significant prognostic information about metastases to the liver P = 0.014 0.031 and 0.058 and matched pairs showed a higher prevalence of these risk factors in the samples with distant spread P = 0.029; Silencing of miR-34a and upregulation of c-Met Snail and β-catenin expression is associated with liver metastases of colon cancer; Detection of miR-34a silencing in resected primary colon cancer may be of prognostic value especially in combination with detection of c-Met and β-catenin expression;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004;c-Met is a target of miR-34a and regulates the migration and invasion of osteosarcoma cells; Osteosarcoma cells over-expressing miR-34a exhibited a significant decrease in the expression levels of c-Met mRNA and protein simultaneously; The results presented in this study demonstrated that over-expression of miR-34a could inhibit the tumor growth and metastasis of osteosarcoma probably through down regulating c-Met; And there are other putative miR-34a target genes beside c-Met which could potentially be key players in the development of osteosarcoma;Underexpression of miR 34a in hepatocellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting c MET; In addition miR-34a mimic enhanced the effect of cell proliferation inhibition and caspase activity induction of agents targeting c-MET siRNAs and small molecular inhibitor su11274;miR 34a inhibits migration and invasion by down regulation of c Met expression in human hepatocellular carcinoma cells; miR-34a directly targeted c-Met and reduced both mRNA and protein levels of c-Met; thus decreased c-Met-induced phosphorylation of extracellular signal-regulated kinases 1 and 2 ERK1/2; Taken together these results provide evidence to show the suppression role of miR-34a in tumor migration and invasion through modulation of the c-Met signaling pathway;miR-34a levels in human gliomas inversely correlated to c-Met levels measured in the same tumors; Forced expression of c-Met or Notch-1/Notch-2 transcripts lacking the 3'-untranslated region sequences partially reversed the effects of miR-34a on cell cycle arrest and cell death in glioma cells and stem cells respectively; They show that miR-34a suppresses brain tumor growth by targeting c-Met and Notch;MicroRNA 34a inhibits uveal melanoma cell proliferation and migration through downregulation of c Met; In addition expression of c-Met and cell cycle-related proteins was determined by Western blotting and immunofluorescence after the introduction of miR-34a miR-34a is actively expressed in melanocytes but not in uveal melanoma cells based on Northern blot analysis; After identification of two putative miR-34a binding sites within the 3' UTR of the human c-Met mRNA miR-34a was shown to suppress luciferase activity using HEK293 cells with a luciferase reporter construct containing the binding sites; miR-34a was confirmed to downregulate the expression of c-Met protein by Western blotting and immunofluorescence; These results demonstrate that miR-34a acts as a tumor suppressor in uveal melanoma cell proliferation and migration through the downregulation of c-Met metastasis;;metastasis;;;; colon cancer;lung cancer;sarcoma;liver cancer;liver cancer;glioblastoma;melanoma hsa-miR-140-5p METTL1 -0.755971041589807 9.68060922934542e-14 0.870290498548656 7.17135365967024e-31 miRanda -0.155211314090563 1.97903878485538e-09 NA NA NA hsa-miR-152-3p MGAT4A -0.26603867075042 0.0063861560676033 0.493804333900288 3.29725111038758e-05 MirTarget -0.112152777421597 0.00773681774096472 NA NA NA hsa-miR-140-5p MIPOL1 -0.755971041589807 9.68060922934542e-14 0.357116995366797 0.00180032704342608 PITA;miRanda;miRNATAP -0.17751369613213 3.16697070724869e-06 NA NA NA hsa-miR-34a-5p MLC1 0.129201805242403 0.133261654068224 -0.00602240290377876 0.981829799025522 mirMAP -0.424270151254683 6.02456206498475e-05 NA NA NA hsa-miR-140-5p MMP13 -0.755971041589807 9.68060922934542e-14 6.71640412670262 7.74215774273361e-81 miRNAWalker2_validate -0.338768049196554 0.00944202951153073 NA NA NA hsa-miR-140-5p MOAP1 -0.755971041589807 9.68060922934542e-14 -0.0885110850384718 0.215376940800626 miRanda -0.163733324587215 3.33184401085567e-12 NA NA NA hsa-miR-140-5p MPP2 -0.755971041589807 9.68060922934542e-14 -0.162235911869042 0.377919315107307 PITA -0.312695842713591 3.02633842941366e-07 NA NA NA hsa-miR-140-5p MPP7 -0.755971041589807 9.68060922934542e-14 -0.5147861343601 0.00077345040180734 miRanda -0.252553820974931 7.27544833576438e-07 NA NA NA hsa-miR-140-5p MRPL17 -0.755971041589807 9.68060922934542e-14 1.00679596033877 1.95241823571098e-45 miRanda -0.149780083712489 1.80922950131553e-09 NA NA NA hsa-miR-140-5p MRPL43 -0.755971041589807 9.68060922934542e-14 0.264016336333111 2.64209960222599e-05 miRanda -0.17544983137863 1.76287258449602e-17 NA NA NA hsa-miR-140-5p MRPS14 -0.755971041589807 9.68060922934542e-14 0.457842100416533 2.46562278376615e-16 miRanda -0.13306120107073 1.13914234863137e-12 NA NA NA hsa-miR-140-5p MSTO2P -0.755971041589807 9.68060922934542e-14 0.437338898785697 5.23716445835305e-06 miRanda -0.143071046723163 8.19992139516088e-06 NA NA NA hsa-miR-194-5p MTMR6 0.467781870340114 1.0386810618625e-07 -0.336310616755142 1.20995963568127e-06 MirTarget -0.115655142139417 1.85689738028083e-05 NA NA NA hsa-miR-140-5p MUS81 -0.755971041589807 9.68060922934542e-14 0.456108485635146 8.87123371682572e-13 miRanda -0.114941367131305 8.13072372040469e-08 NA NA NA hsa-miR-140-5p MYB -0.755971041589807 9.68060922934542e-14 1.3385004671291 4.8746375657764e-10 miRanda -0.713881791293094 4.82509990083579e-24 NA NA NA hsa-miR-34a-5p MYC 0.129201805242403 0.133261654068224 -1.13124656428776 3.22608205108151e-16 miRNAWalker2_validate;miRTarBase -0.216308870548993 0.000129276161670072 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-140-5p MYO6 -0.755971041589807 9.68060922934542e-14 0.64462966298129 1.058698364996e-10 miRanda -0.19671764385356 3.92236375518869e-09 NA NA NA hsa-miR-34a-5p MYRIP 0.129201805242403 0.133261654068224 -2.17370145905386 1.8691130119275e-20 miRNATAP -0.531237009913779 2.89043646633229e-08 NA NA NA hsa-miR-140-5p NAA20 -0.755971041589807 9.68060922934542e-14 0.753255447957756 1.61926566288313e-30 MirTarget;miRanda;miRNATAP -0.131700906266271 4.94992444476941e-09 NA NA NA hsa-miR-140-5p NAGK -0.755971041589807 9.68060922934542e-14 0.818177932191468 1.18507184836376e-31 miRanda -0.13556102997533 1.73435183389951e-08 NA NA NA hsa-miR-34a-5p NAP1L5 0.129201805242403 0.133261654068224 -1.09993598867014 5.12983053371275e-25 miRNATAP -0.116263799019501 0.00825877505443093 NA NA NA hsa-miR-140-5p NAT1 -0.755971041589807 9.68060922934542e-14 2.14616171100344 1.04720393429475e-12 miRanda -0.878673326856451 1.48107547999627e-18 NA NA NA hsa-miR-34a-5p NAT8L 0.129201805242403 0.133261654068224 -2.93784052922262 7.82426389917244e-41 MirTarget -0.29895802749646 0.00125022613036032 NA NA NA hsa-miR-34a-5p NAV3 0.129201805242403 0.133261654068224 -1.78347027501907 7.45924181306669e-19 MirTarget -0.183656351727409 0.0261329677805879 NA NA NA hsa-miR-194-5p NBEA 0.467781870340114 1.0386810618625e-07 -0.839776830944797 1.66396522124089e-06 miRNATAP -0.200042530980539 0.00357341171134109 NA NA NA hsa-miR-140-5p NDUFA2 -0.755971041589807 9.68060922934542e-14 0.708025405377122 5.97634787767902e-15 miRanda -0.274482985195026 7.66061605111037e-20 NA NA NA hsa-miR-140-5p NDUFS8 -0.755971041589807 9.68060922934542e-14 0.946305841911349 1.86239603309053e-19 miRanda -0.259083655110857 2.24515429388266e-13 NA NA NA hsa-miR-140-5p NEK11 -0.755971041589807 9.68060922934542e-14 0.128069407523834 0.188727293195575 miRanda -0.221923273963315 4.80684731674353e-12 NA NA NA hsa-miR-140-5p NEK8 -0.755971041589807 9.68060922934542e-14 0.661666513407367 2.48062921117499e-12 miRanda -0.255748307530068 3.74729348024003e-16 NA NA NA hsa-miR-140-5p NELL1 -0.755971041589807 9.68060922934542e-14 0.559671843191762 0.100112035151243 miRanda -0.29663437482707 0.00906883404207911 NA NA NA hsa-miR-140-5p NEU1 -0.755971041589807 9.68060922934542e-14 0.795480012952627 1.34529583329152e-31 miRanda -0.128902292083854 3.66529874118497e-08 NA NA NA hsa-miR-152-3p NEURL4 -0.26603867075042 0.0063861560676033 0.0536725973819774 0.438651457878753 MirTarget -0.170344748450189 1.48784403367558e-12 NA NA NA hsa-miR-194-5p NFAT5 0.467781870340114 1.0386810618625e-07 -1.19902512228777 7.36927955059717e-50 miRNATAP -0.127013805342984 0.000142318500250381 NA NA NA hsa-miR-34a-5p NFIC 0.129201805242403 0.133261654068224 -0.323552442007893 0.00148597690443502 mirMAP -0.11905578972851 0.0036063142131713 NA NA NA hsa-miR-34a-5p NGFR 0.129201805242403 0.133261654068224 -2.50042294481334 5.32154099004444e-27 mirMAP -0.493588136203429 2.5977817562076e-07 NA NA NA hsa-miR-194-5p NIPSNAP3B 0.467781870340114 1.0386810618625e-07 -2.78696828513534 6.83594322919934e-98 MirTarget -0.167435331209015 0.00419367581381659 NA NA NA hsa-miR-140-5p NKD1 -0.755971041589807 9.68060922934542e-14 0.687327063082442 3.30390073218128e-06 miRanda -0.100904832941356 0.0421314604872354 NA NA NA hsa-miR-140-5p NLK -0.755971041589807 9.68060922934542e-14 0.568183653225175 4.68554951142873e-14 MirTarget;PITA;miRanda;miRNATAP -0.139208185186153 3.98951586060413e-08 NA NA NA hsa-miR-152-3p NLK -0.26603867075042 0.0063861560676033 0.568183653225175 4.68554951142873e-14 MirTarget -0.121964596915363 5.58054397729548e-06 NA NA NA hsa-miR-194-5p NMB 0.467781870340114 1.0386810618625e-07 -1.75104103306539 5.26163997643681e-34 MirTarget -0.158325515191294 0.00680848311417808 NA NA NA hsa-miR-140-5p NME4 -0.755971041589807 9.68060922934542e-14 0.947356378223932 1.89145158836779e-23 miRanda -0.314401674353955 3.7489316096975e-23 NA NA NA hsa-miR-34a-5p NNT 0.129201805242403 0.133261654068224 -0.328696312785028 0.00101961894282938 miRNAWalker2_validate -0.104869192236743 0.00912053486943876 NA NA NA hsa-miR-34a-5p NOS1AP 0.129201805242403 0.133261654068224 -0.675518736834807 0.00068091520217485 miRNATAP -0.338867031783773 2.14186250461068e-05 NA NA NA hsa-miR-34a-5p NOTCH2 0.129201805242403 0.133261654068224 -0.56663957212087 4.13195343694927e-10 miRNAWalker2_validate;miRNATAP -0.108914801108399 0.00301789969264899 NA NA NA hsa-miR-152-3p NPEPL1 -0.26603867075042 0.0063861560676033 0.406180685889606 6.16352625095454e-05 MirTarget -0.239730748349568 1.38689927392818e-11 NA NA NA hsa-miR-152-3p NR2C2AP -0.26603867075042 0.0063861560676033 0.99538341284987 5.57447062201789e-33 MirTarget -0.224015829864567 1.00128115654516e-13 NA NA NA hsa-miR-140-5p NRIP1 -0.755971041589807 9.68060922934542e-14 -0.227847544372785 0.056714122762498 MirTarget;miRanda -0.130915049738569 0.00102618836558493 NA NA NA hsa-miR-194-5p NRP1 0.467781870340114 1.0386810618625e-07 -1.2092340225481 1.60964437652292e-34 miRNATAP -0.212008975420303 1.03267918282642e-07 NA NA NA hsa-miR-34a-5p NTN1 0.129201805242403 0.133261654068224 -0.338999961041738 0.04596914368363 mirMAP -0.195551221366116 0.00411696924024783 NA NA NA hsa-miR-140-5p NTN4 -0.755971041589807 9.68060922934542e-14 -1.66322280404212 2.8363707662969e-15 MirTarget;miRanda -0.192554969004578 0.00712472667676358 NA NA NA hsa-miR-140-5p NUCB2 -0.755971041589807 9.68060922934542e-14 0.670385380475985 8.68806334102954e-09 miRanda -0.125360421493529 0.00138066858701869 NA NA NA hsa-miR-194-5p OPCML 0.467781870340114 1.0386810618625e-07 -0.152585446356833 0.475856153293485 miRNATAP -0.275784379221859 0.000919370665228909 NA NA NA hsa-miR-140-5p OPLAH -0.755971041589807 9.68060922934542e-14 0.600870870429849 1.1833206273782e-05 miRanda -0.277920393358199 1.09871830041419e-09 NA NA NA hsa-miR-194-5p OR51E2 0.467781870340114 1.0386810618625e-07 0.162950378336555 0.351963713575747 MirTarget -0.361508491435415 9.39030620647483e-08 NA NA NA hsa-miR-140-5p OSBPL6 -0.755971041589807 9.68060922934542e-14 0.353016330690283 0.0415531126921937 MirTarget;PITA;miRanda;miRNATAP -0.145071147931572 0.0121829061374234 NA NA NA hsa-miR-194-5p OSBPL8 0.467781870340114 1.0386810618625e-07 -0.597116166688471 4.67806844867655e-09 MirTarget -0.148869867764701 0.000195301403112586 NA NA NA hsa-miR-194-5p OSTM1 0.467781870340114 1.0386810618625e-07 -0.528607916390317 6.96950270756952e-16 MirTarget -0.152860139041752 2.76861139612176e-09 NA NA NA hsa-miR-140-5p OTUB2 -0.755971041589807 9.68060922934542e-14 1.04819143562664 1.51953841962343e-30 miRanda -0.2030459614938 8.53377022936755e-11 NA NA NA hsa-miR-140-5p P2RX4 -0.755971041589807 9.68060922934542e-14 0.891147185889723 3.77558823703214e-29 miRanda -0.26038169360885 2.48317564105978e-22 NA NA NA hsa-miR-34a-5p P2RY14 0.129201805242403 0.133261654068224 -1.71578253270711 9.75110006776043e-37 MirTarget -0.165254541692172 0.00367464794509594 NA NA NA hsa-miR-140-5p PADI3 -0.755971041589807 9.68060922934542e-14 0.159517457485374 0.619053251982475 miRanda -0.239337674521377 0.0254805486329772 NA NA NA hsa-miR-194-5p PAFAH1B1 0.467781870340114 1.0386810618625e-07 -0.548317907066775 2.37744880696866e-26 miRNATAP -0.117401775594856 1.09041190468924e-08 NA NA NA hsa-miR-140-5p PANK3 -0.755971041589807 9.68060922934542e-14 0.276061257918443 0.00865077517028964 miRanda -0.14155713959785 5.32385605735901e-05 NA NA NA hsa-miR-140-5p PARD6B -0.755971041589807 9.68060922934542e-14 1.70997497031339 2.55366919190462e-20 miRanda -0.523507722714555 3.66346033089813e-17 NA NA NA hsa-miR-194-5p PARVA 0.467781870340114 1.0386810618625e-07 -0.983307300506994 6.1666432826974e-44 MirTarget -0.174916261996288 1.27404481158323e-09 NA NA NA hsa-miR-34a-5p PAX5 0.129201805242403 0.133261654068224 0.186405982880343 0.536149721725608 mirMAP -0.366272492677797 0.00242247877534153 NA NA NA hsa-miR-140-5p PAX9 -0.755971041589807 9.68060922934542e-14 1.50739706624376 4.51792242443721e-11 PITA;miRanda;miRNATAP -0.47403078448731 6.19952697995921e-10 NA NA NA hsa-miR-34a-5p PDE4B 0.129201805242403 0.133261654068224 -0.751531967429292 1.00328243910391e-05 MirTarget -0.141039723199721 0.0399969077756168 NA NA NA hsa-miR-34a-5p PDGFRA 0.129201805242403 0.133261654068224 -1.84169721584144 2.50038285124215e-31 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.257308196495663 9.23678964579895e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-140-5p PDIK1L -0.755971041589807 9.68060922934542e-14 0.465396504296977 1.19867689993514e-10 miRanda -0.106665372125865 1.11595400775704e-05 NA NA NA hsa-miR-34a-5p PDZRN3 0.129201805242403 0.133261654068224 -1.3635898424795 3.72591982347471e-27 miRNATAP -0.175620028395096 0.00079003204867597 NA NA NA hsa-miR-34a-5p PEG10 0.129201805242403 0.133261654068224 -0.95352146824468 0.00369200350510654 miRNATAP -0.273016344888801 0.0388193317050166 NA NA NA hsa-miR-194-5p PER3 0.467781870340114 1.0386810618625e-07 -1.22424368381498 2.80442230784446e-27 miRNATAP -0.16418165018 0.000305333027407605 NA NA NA hsa-miR-140-5p PFKFB4 -0.755971041589807 9.68060922934542e-14 1.46356567497396 5.553830008223e-57 miRanda -0.291233206289114 1.82173891750518e-19 NA NA NA hsa-miR-34a-5p PFKM 0.129201805242403 0.133261654068224 -0.167575311099228 0.0685593901261937 MirTarget -0.157438956681627 1.85297175801738e-05 NA NA NA hsa-miR-194-5p PGAP1 0.467781870340114 1.0386810618625e-07 -1.31559839003994 2.62464485048632e-27 mirMAP -0.176317400784185 0.000306342582956409 NA NA NA hsa-miR-140-5p PGAP2 -0.755971041589807 9.68060922934542e-14 0.566840247177188 1.62169175074113e-17 miRanda -0.158002964865803 1.55141752974302e-12 NA NA NA hsa-miR-140-5p PGP -0.755971041589807 9.68060922934542e-14 1.28708655220271 1.99547006668391e-44 miRanda -0.260240179079275 3.47581876707274e-16 NA NA NA hsa-miR-140-5p PIGT -0.755971041589807 9.68060922934542e-14 0.747766091492472 6.5234321176848e-20 miRanda -0.205889732821643 7.85399540699907e-14 NA NA NA hsa-miR-140-5p PILRB -0.755971041589807 9.68060922934542e-14 0.163733301725676 0.136057696767546 miRanda -0.181370762995613 6.53033798842528e-07 NA NA NA hsa-miR-140-5p PIN1 -0.755971041589807 9.68060922934542e-14 0.799481409833677 1.34100347777179e-14 miRanda;miRNATAP -0.247021751811369 1.20684789405659e-12 NA NA NA hsa-miR-140-5p PIP4K2C -0.755971041589807 9.68060922934542e-14 0.785545156337934 1.33112420136684e-29 miRanda -0.175848307281286 1.16166550898799e-13 NA NA NA hsa-miR-140-5p PIPSL -0.755971041589807 9.68060922934542e-14 0.670349529792195 8.05347011162299e-27 miRanda -0.115230767741954 7.09536176780883e-08 NA NA NA hsa-miR-194-5p PJA2 0.467781870340114 1.0386810618625e-07 -0.861595497733361 1.07188296663498e-25 MirTarget -0.192461154492164 4.12657568270207e-09 NA NA NA hsa-miR-194-5p PKD2 0.467781870340114 1.0386810618625e-07 -1.64090715886338 1.07849232924274e-56 miRNATAP -0.310767187504262 3.26949089593953e-13 NA NA NA hsa-miR-34a-5p PKIA 0.129201805242403 0.133261654068224 -1.53571066596047 4.62934386564947e-14 MirTarget;miRNATAP -0.176305150984532 0.0338330175601233 NA NA NA hsa-miR-34a-5p PKP2 0.129201805242403 0.133261654068224 -0.390200657208209 0.00466318031568261 miRNAWalker2_validate -0.138803551058529 0.0122639702472858 NA NA NA hsa-miR-140-5p PLA2G12A -0.755971041589807 9.68060922934542e-14 -0.0767339324942657 0.320227624149064 miRanda -0.111542024637763 1.35365987147148e-05 NA NA NA hsa-miR-34a-5p PLCB1 0.129201805242403 0.133261654068224 -1.66992751550185 3.40855270132597e-21 miRNATAP -0.159895868887965 0.0280175727961689 NA NA NA hsa-miR-140-5p PLEKHG3 -0.755971041589807 9.68060922934542e-14 0.186460167381627 0.0152232630190883 PITA;miRanda;miRNATAP -0.181428716226831 7.51934272916668e-13 NA NA NA hsa-miR-34a-5p PLEKHM3 0.129201805242403 0.133261654068224 -1.84131497880035 1.34528076669196e-67 MirTarget -0.205868801316952 8.11205347490128e-06 NA NA NA hsa-miR-194-5p PLXDC1 0.467781870340114 1.0386810618625e-07 -0.181187214482674 0.0645908903217389 mirMAP -0.234304507054875 5.79035336100431e-10 NA NA NA hsa-miR-34a-5p PLXNA4 0.129201805242403 0.133261654068224 -3.24060572750455 3.5769955557962e-61 mirMAP -0.189403982380291 0.0262187870956818 NA NA NA hsa-miR-140-5p PMAIP1 -0.755971041589807 9.68060922934542e-14 1.5190355795424 7.37304528466062e-22 miRanda -0.19401318752549 0.000334650587616517 NA NA NA hsa-miR-152-3p PNPLA6 -0.26603867075042 0.0063861560676033 0.440360643717122 2.15136983662257e-09 MirTarget -0.157368035674332 1.28784085958805e-09 NA NA NA hsa-miR-34a-5p POGZ 0.129201805242403 0.133261654068224 0.221455188654849 0.000545925051104238 miRNAWalker2_validate;MirTarget;miRNATAP -0.115996515542842 5.93563351087292e-06 NA NA NA hsa-miR-140-5p POLR2L -0.755971041589807 9.68060922934542e-14 0.467688808822406 2.72127894755399e-06 miRanda -0.218877421363916 3.75001177522343e-11 NA NA NA hsa-miR-140-5p POSTN -0.755971041589807 9.68060922934542e-14 1.95056974229455 5.25551662563458e-27 miRanda -0.211802642642831 0.000697652787214553 NA NA NA hsa-miR-34a-5p POU6F1 0.129201805242403 0.133261654068224 -1.22160046868415 5.22496483078127e-46 MirTarget -0.117274152775026 0.00127533239641509 NA NA NA hsa-miR-34a-5p PPARGC1B 0.129201805242403 0.133261654068224 -1.46182968985053 1.35672112520709e-22 MirTarget;miRNATAP -0.172605157371696 0.00507730166736354 NA NA NA hsa-miR-194-5p PPFIBP1 0.467781870340114 1.0386810618625e-07 -0.738206527263465 1.91555687119124e-17 MirTarget -0.214772860595737 3.25190429188205e-10 NA NA NA hsa-miR-194-5p PPP1R12B 0.467781870340114 1.0386810618625e-07 -2.23500813943069 2.60349931631869e-111 mirMAP -0.271508988889945 8.5215673406534e-10 NA NA NA hsa-miR-34a-5p PPP1R16B 0.129201805242403 0.133261654068224 -2.17774746201998 4.8680300203316e-39 MirTarget;miRNATAP -0.359730041507559 2.54742026486253e-07 NA NA NA hsa-miR-194-5p PPP3CA 0.467781870340114 1.0386810618625e-07 -0.544246415257643 5.77237427579346e-09 MirTarget -0.132376274530416 0.000303144003211118 NA NA NA hsa-miR-194-5p PRICKLE2 0.467781870340114 1.0386810618625e-07 -1.41551101306739 1.76700405075257e-30 miRNATAP -0.291494776067705 3.80032824411756e-09 NA NA NA hsa-miR-194-5p PRKCA 0.467781870340114 1.0386810618625e-07 -1.70723657875247 1.7688165305473e-34 mirMAP -0.194734764385864 0.000579018161354159 NA NA NA hsa-miR-34a-5p PRKCQ 0.129201805242403 0.133261654068224 -0.699033121447314 0.000628432051813325 MirTarget -0.177144743171963 0.0314044607368418 NA NA NA hsa-miR-152-3p PRKCZ -0.26603867075042 0.0063861560676033 1.51865275319949 8.17912638952476e-44 MirTarget -0.228144890446044 1.70083864286456e-08 NA NA NA hsa-miR-140-5p PROC -0.755971041589807 9.68060922934542e-14 3.22612346066718 7.9841879274342e-71 miRanda -0.373152810420701 1.37403669377558e-08 NA NA NA hsa-miR-34a-5p PROX1 0.129201805242403 0.133261654068224 -3.30249132498998 3.55828560245591e-41 miRNATAP -0.361076029941872 0.000496659248653518 NA NA NA hsa-miR-152-3p PRR15 -0.26603867075042 0.0063861560676033 2.15801611312615 1.85407919829463e-17 MirTarget -0.416456570296146 4.73169720779315e-06 NA NA NA hsa-miR-140-5p PRSS23 -0.755971041589807 9.68060922934542e-14 0.5826100436921 4.91406099524118e-05 PITA;miRanda -0.199202879666687 3.27030258262544e-05 NA NA NA hsa-miR-152-3p PSMD9 -0.26603867075042 0.0063861560676033 0.39609708699053 3.43470411266283e-11 MirTarget -0.111765817345293 1.26720688439012e-07 NA NA NA hsa-miR-140-5p PSRC1 -0.755971041589807 9.68060922934542e-14 1.97416833805815 1.01965081849198e-62 miRanda -0.138519120446878 0.00115841141835121 NA NA NA hsa-miR-140-5p PTCD1 -0.755971041589807 9.68060922934542e-14 0.715672650818626 1.57159030704783e-28 miRanda -0.136090943110889 7.20084729387234e-10 NA NA NA hsa-miR-140-5p PTP4A2 -0.755971041589807 9.68060922934542e-14 0.38574449513147 1.13328117872512e-06 PITA;miRanda -0.1600421018638 1.26528240189266e-09 NA NA NA hsa-miR-194-5p PTPN13 0.467781870340114 1.0386810618625e-07 -0.809960140594897 7.91282502499025e-08 miRNAWalker2_validate;miRTarBase -0.212234949114894 0.000329485111464793 NA NA NA hsa-miR-140-5p PTPN23 -0.755971041589807 9.68060922934542e-14 0.290068641137925 1.87010609993248e-09 miRanda -0.11507182375105 6.35112674762279e-13 NA NA NA hsa-miR-34a-5p PTPN4 0.129201805242403 0.133261654068224 -0.772006027943853 1.97809004778744e-27 miRNATAP -0.112517391591074 0.000130237676070391 NA NA NA hsa-miR-194-5p PTPRD 0.467781870340114 1.0386810618625e-07 0.150114854210014 0.427806011089459 miRNATAP -0.270401375911969 0.000236732808869456 NA NA NA hsa-miR-34a-5p PTPRM 0.129201805242403 0.133261654068224 -1.57471720317321 4.81055293304317e-48 miRNATAP -0.11487754972156 0.0126724251833949 NA NA NA hsa-miR-140-5p PVT1 -0.755971041589807 9.68060922934542e-14 1.4009830126442 1.80371827813342e-24 miRanda -0.14724952428069 0.000119124480497752 NA NA NA hsa-miR-194-5p RAB11FIP2 0.467781870340114 1.0386810618625e-07 -0.940510639961515 7.61132098193432e-42 MirTarget;miRNATAP -0.158907334906891 1.81802910720866e-08 NA NA NA hsa-miR-140-5p RAB15 -0.755971041589807 9.68060922934542e-14 0.680561480072377 2.91882823982896e-12 miRanda -0.18223788021677 2.58496432029737e-08 NA NA NA hsa-miR-140-5p RAB17 -0.755971041589807 9.68060922934542e-14 1.71789899991612 2.04412624325142e-25 miRanda -0.617022006870894 2.229395264926e-29 NA NA NA hsa-miR-140-5p RAB27B -0.755971041589807 9.68060922934542e-14 0.157909039164941 0.404607674683261 miRanda -0.356590760421617 1.33011910303956e-08 NA NA NA hsa-miR-140-5p RAB31 -0.755971041589807 9.68060922934542e-14 1.21770647114932 2.0308057149131e-20 miRanda -0.21012994534455 2.68895292831316e-06 NA NA NA hsa-miR-152-3p RAB39B -0.26603867075042 0.0063861560676033 0.482072090722851 0.0185769063770752 MirTarget -0.185886121104447 0.0101455062867969 NA NA NA hsa-miR-194-5p RAB6B 0.467781870340114 1.0386810618625e-07 -1.3809693710295 1.41420129464503e-25 miRNATAP -0.113635383210441 0.0323817201069188 NA NA NA hsa-miR-140-5p RABEPK -0.755971041589807 9.68060922934542e-14 0.564256137730052 4.21268617636926e-21 miRanda -0.150199845204399 9.15276840000391e-14 NA NA NA hsa-miR-140-5p RABIF -0.755971041589807 9.68060922934542e-14 1.16947749398343 5.52264059742422e-66 miRanda -0.107792740696782 1.1905190069924e-05 NA NA NA hsa-miR-140-5p RALGPS1 -0.755971041589807 9.68060922934542e-14 0.320371955401898 0.000743623076739109 PITA;miRanda -0.243566251788016 6.7508487829722e-15 NA NA NA hsa-miR-140-5p RALGPS2 -0.755971041589807 9.68060922934542e-14 0.889426971470516 5.63881052160942e-09 PITA;miRanda;miRNATAP -0.375324646037026 1.34649225851494e-13 NA NA NA hsa-miR-140-5p RANBP3L -0.755971041589807 9.68060922934542e-14 -1.79068150652767 1.82152099503875e-10 miRanda -0.214390110801069 0.0238744647045864 NA NA NA hsa-miR-152-3p RANGAP1 -0.26603867075042 0.0063861560676033 1.04151157017638 2.45311112109221e-37 MirTarget -0.138004959293777 4.16179738367187e-06 NA NA NA hsa-miR-34a-5p RASL12 0.129201805242403 0.133261654068224 -1.26839848073461 4.1008746921965e-29 MirTarget -0.204536379062962 1.30071298228715e-05 NA NA NA hsa-miR-140-5p RBM11 -0.755971041589807 9.68060922934542e-14 0.464040777071611 0.0239863965066427 miRanda -0.348663967915966 3.31636592138044e-07 NA NA NA hsa-miR-152-3p RBM24 -0.26603867075042 0.0063861560676033 -0.541667628704172 0.0692752095429657 MirTarget -0.217919048361615 0.0384813546638841 NA NA NA hsa-miR-194-5p RBMS2 0.467781870340114 1.0386810618625e-07 -1.23357079611651 3.68367464498493e-73 mirMAP -0.153249099814303 1.15529035769481e-07 NA NA NA hsa-miR-140-5p RCOR3 -0.755971041589807 9.68060922934542e-14 0.0134479863356063 0.860878496395692 miRanda -0.105142227820074 3.70177362982551e-05 NA NA NA hsa-miR-34a-5p RELN 0.129201805242403 0.133261654068224 -4.67087443281158 1.50848083381937e-55 miRNATAP -0.695025679503336 4.68377105693281e-08 NA NA NA hsa-miR-194-5p REV3L 0.467781870340114 1.0386810618625e-07 -1.3253111779694 1.09960253991236e-38 miRNATAP -0.120006733245659 0.00392419946133993 NA NA NA hsa-miR-140-5p RGMB -0.755971041589807 9.68060922934542e-14 -0.520723607828337 4.64803192513627e-12 PITA;miRanda;miRNATAP -0.103483059848973 4.50711230136737e-05 NA NA NA hsa-miR-34a-5p RGP1 0.129201805242403 0.133261654068224 -0.480835927395348 4.47249507470598e-06 mirMAP -0.173237724008973 3.92258960929152e-05 NA NA NA hsa-miR-140-5p RHOH -0.755971041589807 9.68060922934542e-14 0.95449646771927 1.46489117348312e-07 miRanda -0.302742009971521 6.24716323223184e-07 NA NA NA hsa-miR-152-3p RIBC1 -0.26603867075042 0.0063861560676033 1.02825222594949 3.24338701300761e-13 MirTarget -0.188623027669473 0.000183141348262366 NA NA NA hsa-miR-194-5p RICTOR 0.467781870340114 1.0386810618625e-07 -0.572696811642445 2.30364963045589e-12 MirTarget -0.107615474578424 0.000818752229475053 NA NA NA hsa-miR-34a-5p RIMS3 0.129201805242403 0.133261654068224 -1.82635174452916 4.12617185172086e-37 MirTarget;miRNATAP -0.193880341560836 0.00128738877180812 NA NA NA hsa-miR-34a-5p RIMS4 0.129201805242403 0.133261654068224 1.93936813754878 1.60005847788467e-09 miRNATAP -0.271682955499854 0.0371868494799039 NA NA NA hsa-miR-194-5p RNF125 0.467781870340114 1.0386810618625e-07 -1.5681117959047 5.10792986637577e-47 MirTarget -0.14064550632467 0.00175091045855393 NA NA NA hsa-miR-194-5p RNF152 0.467781870340114 1.0386810618625e-07 -0.111402929987169 0.369173650101352 mirMAP -0.123061615842018 0.0108110715088466 NA NA NA hsa-miR-152-3p ROGDI -0.26603867075042 0.0063861560676033 1.63634123562284 4.86370461071376e-50 MirTarget -0.287416600753171 1.85004984869928e-12 NA NA NA hsa-miR-140-5p RPUSD2 -0.755971041589807 9.68060922934542e-14 0.469486437259917 1.22876340718009e-14 MirTarget -0.126755713520645 5.428889932252e-10 NA NA NA hsa-miR-194-5p RRAS2 0.467781870340114 1.0386810618625e-07 -1.34328469535129 7.92387097337765e-28 MirTarget -0.117935307120199 0.017228036710531 NA NA NA hsa-miR-140-5p RSAD1 -0.755971041589807 9.68060922934542e-14 0.231697290919293 0.00103938720197615 miRanda -0.183764463453446 2.48563188771459e-15 NA NA NA hsa-miR-140-5p RTKN -0.755971041589807 9.68060922934542e-14 1.29492093513268 4.15162188834918e-51 miRanda -0.138847115371902 5.35739906946591e-06 NA NA NA hsa-miR-140-5p RUSC1 -0.755971041589807 9.68060922934542e-14 1.42962802203877 1.99831752006711e-73 miRanda -0.267802888240243 1.9978519804073e-21 NA NA NA hsa-miR-140-5p RUVBL1 -0.755971041589807 9.68060922934542e-14 1.08405592163913 6.7091844654157e-50 miRanda -0.115192679042016 8.12213333695103e-06 NA NA NA hsa-miR-194-5p SALL1 0.467781870340114 1.0386810618625e-07 -0.348151775813103 0.0746323035364776 MirTarget;miRNATAP -0.334172486742104 1.04161682311778e-05 NA NA NA hsa-miR-194-5p SAMD4A 0.467781870340114 1.0386810618625e-07 -1.7968635515046 2.10294718067867e-53 miRNATAP -0.233587834454422 1.40558270842054e-06 NA NA NA hsa-miR-194-5p SAMD8 0.467781870340114 1.0386810618625e-07 -1.02596634412093 2.61875625350706e-22 MirTarget -0.106602542491614 0.0116095095023452 NA NA NA hsa-miR-194-5p SATB1 0.467781870340114 1.0386810618625e-07 -1.56127568524025 3.5724533657613e-30 miRNATAP -0.148373002098721 0.00727896827340906 NA NA NA hsa-miR-34a-5p SATB1 0.129201805242403 0.133261654068224 -1.56127568524025 3.5724533657613e-30 MirTarget;miRNATAP -0.154518355550859 0.00666210831392197 NA NA NA hsa-miR-140-5p SCGB2A1 -0.755971041589807 9.68060922934542e-14 -0.285150586947695 0.464266297353636 miRanda -0.398305199505209 0.00217646604757875 NA NA NA hsa-miR-140-5p SCGB2A2 -0.755971041589807 9.68060922934542e-14 -1.53507753311163 0.00777502908192117 miRanda -0.788650513063007 4.11448611003728e-05 NA NA NA hsa-miR-34a-5p SCN1A 0.129201805242403 0.133261654068224 0.743694894902573 0.0150562525914744 miRNATAP -0.332163469670154 0.006869962982592 NA NA NA hsa-miR-34a-5p SCN2B 0.129201805242403 0.133261654068224 -3.86249794050417 7.57828818937623e-49 MirTarget;miRNATAP -0.317392590664706 0.00467101122494991 NA NA NA hsa-miR-140-5p SDHC -0.755971041589807 9.68060922934542e-14 0.614848488992624 6.21118664091674e-26 miRanda -0.101747538542186 3.41771470167581e-07 NA NA NA hsa-miR-34a-5p SDK2 0.129201805242403 0.133261654068224 -1.46435315270485 4.01650020293667e-10 miRNATAP -0.253802187360148 0.00753786468900873 NA NA NA hsa-miR-194-5p SEMA5A 0.467781870340114 1.0386810618625e-07 -1.71262315110065 2.1761661277251e-29 mirMAP -0.355607914642005 5.41224008961489e-09 NA NA NA hsa-miR-194-5p SESTD1 0.467781870340114 1.0386810618625e-07 -0.827342931728161 2.16755903388799e-18 mirMAP -0.171835892027958 4.48389809010474e-06 NA NA NA hsa-miR-140-5p SEZ6L -0.755971041589807 9.68060922934542e-14 0.728926532721306 0.0271208058476389 miRanda -0.478481362753088 1.32450257011793e-05 NA NA NA hsa-miR-34a-5p SH3PXD2A 0.129201805242403 0.133261654068224 -0.038658231698439 0.664094392746129 MirTarget -0.12357112462918 0.000519126591402531 NA NA NA hsa-miR-34a-5p SHANK3 0.129201805242403 0.133261654068224 -1.33183457706851 3.20517661766363e-41 mirMAP -0.1851287441907 8.85443065320655e-06 NA NA NA hsa-miR-140-5p SHROOM2 -0.755971041589807 9.68060922934542e-14 1.18660186226586 1.82985501782275e-21 miRanda -0.249910768095372 3.65032766075333e-09 NA NA NA hsa-miR-140-5p SHROOM3 -0.755971041589807 9.68060922934542e-14 0.488940714880925 0.000112620796190186 MirTarget;PITA;miRanda;miRNATAP -0.286092751449744 8.82599950415578e-12 NA NA NA hsa-miR-140-5p SIDT1 -0.755971041589807 9.68060922934542e-14 0.553149117327226 0.00660966681649986 miRanda -0.512377333505074 2.20219345110995e-14 NA NA NA hsa-miR-34a-5p SIK2 0.129201805242403 0.133261654068224 -2.29859523998516 3.63982740667992e-106 mirMAP -0.142460260518517 0.00308404568404783 NA NA NA hsa-miR-34a-5p SIRT1 0.129201805242403 0.133261654068224 -0.599221126327341 9.41183428987515e-17 miRNAWalker2_validate;miRTarBase;miRNATAP -0.123259850748874 2.68231130307605e-05 22623155;25826085;25982144;21067862;20687223;23954321;26722316;27126903;26518892;18834855 MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Dysregulation of the miR 34a SIRT1 axis inhibits breast cancer stemness; Sirtuin-1 SIRT1 is a direct target of miR-34a; Here we found low levels of miR-34a and high levels of SIRT1 in CD44+/CD24- breast cancer stem cells BCSCs; MiR-34a overexpression and knockdown of SIRT1 decreased proportion of BSCSs and mammosphere formation; In nude mice xenografts stable expression of miR-34a and silencing of SIRT1 reduced tumor burden; Taken together our results demonstrated that miR-34a inhibits proliferative potential of BCSCs in vitro and in vivo at least partially by downregulating SIRT1;5 Aminolevulinic acid mediated sonodynamic therapy induces anti tumor effects in malignant melanoma via p53 miR 34a Sirt1 axis; Therefore the p53 miR-34a and SIRT1 constituted a positive feedback loop;Sirt1 which is one of the target genes for miR-34a and related to drug-resistance was strikingly up-regulated in the 5-FU-resistant cells; The ectopic expression of miR-34a in the 5-FU-resistant cells inhibited growth as in the parental cells and attenuated the resistance to 5-FU through the down-regulation of Sirt1 and E2F3; These findings suggest that miR-34a targeting the Sirt1 and E2F3 genes could negatively regulate at least in part the resistance to 5-FU in human colorectal cancer DLD-1 cells;We aimed to elucidate the molecular mechanisms underlying paclitaxel resistance of hormone-refractory prostate cancer with a special focus on the roles of miR-34a and SIRT1; MiR-34a over-expression and SIRT1 knockdown attenuated paclitaxel resistance of PC3PR cells; Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;Interestingly RES increased the intracellular expression level of miR-34a which down-regulated the target gene E2F3 and its downstream Sirt1 resulting in growth inhibition;miR 34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression; The role of miR-34a in regulating sirtuin 1 SIRT1 in prostate cancer remains unclear; The objective of the present study was to investigate the biological function and molecular mechanisms of miR-34a regulation of SIRT1 in human prostate cancer samples and the human prostate cancer cell line PC-3; Fresh prostate tissues were obtained from patients and the miR-34a expression in prostate cancer tissues was measured using reverse transcription-quantitative polymerase chain reaction RT-qPCR qPCR and western blotting were performed to assess the effects of miR-34a overexpression on SIRT1 regulation in PC-3 cells and the cell growth was assessed by Cell Counting Kit-8 CCK-8; SIRT1 expression levels in PC-3 cells with over-expression of miR-34a were significantly reduced compared with those in the negative control P<0.05; In conclusion miR-34a inhibits the human prostate cancer cell proliferation in part through the downregulation of SIRT1 expression;In addition the present micellar system facilitated the escape of miR-34a from the endosome and release of DOX into the cell nucleus leading to the downregulation of silent information regulator 1 SIRT1 expression and inhibition of DU145 and PC3 androgen-independent prostate cancer cell proliferation;For example overexpressing miR-34a a master regulator of tumor suppression attenuates chemoresistance to 5-FU by downregulating silent information regulator 1 SIRT1 and E2F3;In PC3 cell ectopic expression of miR-34a decreased the SIRT1 mRNA and protein levels as well as protein levels of known direct target genes; Reporter assays revealed that miR-34a-induced SIRT1 inhibition occurred at the transcriptional but not post-transcriptional level despite the presence of a potential miR-34a binding site within its 3'-UTR ;;malignant trasformation;drug resistance;drug resistance;;;;drug resistance; breast cancer;breast cancer;melanoma;colon cancer;prostate cancer;colon cancer;prostate cancer;prostate cancer;colorectal cancer;prostate cancer hsa-miR-152-3p SIRT7 -0.26603867075042 0.0063861560676033 1.08383105862547 2.36777309777559e-35 MirTarget -0.245284597286202 9.47217513518723e-15 NA NA NA hsa-miR-140-5p SLC12A8 -0.755971041589807 9.68060922934542e-14 1.8269825690504 1.49556403484393e-61 miRanda -0.103303961145423 0.00948231463531679 NA NA NA hsa-miR-140-5p SLC16A14 -0.755971041589807 9.68060922934542e-14 -0.208976120684666 0.0946365190150934 miRanda -0.110369605477419 0.0081753269741956 NA NA NA hsa-miR-140-5p SLC16A6 -0.755971041589807 9.68060922934542e-14 1.58051174117426 2.78683595021654e-10 miRanda -0.649215059365688 6.1815974828296e-15 NA NA NA hsa-miR-152-3p SLC16A6 -0.26603867075042 0.0063861560676033 1.58051174117426 2.78683595021654e-10 MirTarget -0.177870743377656 0.0466458081811941 NA NA NA hsa-miR-140-5p SLC16A9 -0.755971041589807 9.68060922934542e-14 -0.710563979649714 8.27342348907915e-05 miRanda -0.132544352620407 0.028565569775158 NA NA NA hsa-miR-194-5p SLC1A3 0.467781870340114 1.0386810618625e-07 -1.29387866861309 1.87796300026357e-23 MirTarget -0.26456096660257 3.01231421082895e-07 NA NA NA hsa-miR-140-5p SLC22A15 -0.755971041589807 9.68060922934542e-14 0.770140030987174 1.27030257384228e-09 miRanda -0.122930030769802 0.00403523141844778 NA NA NA hsa-miR-140-5p SLC22A17 -0.755971041589807 9.68060922934542e-14 -0.21174084728872 0.130280695362021 miRanda -0.231511951297984 6.2797200655423e-07 NA NA NA hsa-miR-140-5p SLC22A23 -0.755971041589807 9.68060922934542e-14 -0.242865465723709 0.0282568563280217 miRanda -0.198889149285746 6.10786229595958e-08 NA NA NA hsa-miR-194-5p SLC25A27 0.467781870340114 1.0386810618625e-07 -2.61338542336168 2.5890385711066e-47 MirTarget -0.180469175676 0.0158488372315978 NA NA NA hsa-miR-140-5p SLC25A4 -0.755971041589807 9.68060922934542e-14 -0.280573776847234 0.00443737615520052 miRanda -0.129929474349746 7.71659830116955e-05 NA NA NA hsa-miR-140-5p SLC2A1 -0.755971041589807 9.68060922934542e-14 1.49657327542371 9.41739413554663e-37 MirTarget;miRanda;miRNATAP -0.15862393902483 0.000117946307705998 NA NA NA hsa-miR-152-3p SLC2A1 -0.26603867075042 0.0063861560676033 1.49657327542371 9.41739413554663e-37 MirTarget -0.14627536152481 0.00078600763240081 NA NA NA hsa-miR-34a-5p SLC2A13 0.129201805242403 0.133261654068224 -0.422835174294749 0.000265130322874232 miRNATAP -0.104926381270223 0.024562295970415 NA NA NA hsa-miR-194-5p SLC2A3 0.467781870340114 1.0386810618625e-07 -0.73181329100781 1.70465019063554e-09 miRNATAP -0.134686128570479 0.00480116461775915 NA NA NA hsa-miR-140-5p SLC39A9 -0.755971041589807 9.68060922934542e-14 0.262584702640971 8.69315762423641e-05 PITA -0.131248704015871 3.35151836486511e-09 NA NA NA hsa-miR-140-5p SLC46A1 -0.755971041589807 9.68060922934542e-14 -0.307984314207807 0.00250539082651516 miRanda -0.175634498551 2.13904117112642e-07 NA NA NA hsa-miR-140-5p SLC4A8 -0.755971041589807 9.68060922934542e-14 1.27143188110937 7.46578845328289e-09 miRanda -0.746676913555644 3.21162893506366e-25 NA NA NA hsa-miR-194-5p SLC5A3 0.467781870340114 1.0386810618625e-07 -0.728564527931595 1.72377411389955e-12 mirMAP -0.109240326112243 0.00735367078930343 NA NA NA hsa-miR-194-5p SLK 0.467781870340114 1.0386810618625e-07 -0.57237953827141 7.90930897832754e-14 MirTarget -0.111038841860171 0.000236926134767874 NA NA NA hsa-miR-152-3p SNRPD1 -0.26603867075042 0.0063861560676033 0.832161096406318 3.79900745069399e-30 MirTarget -0.114851203773735 1.53995209000664e-05 NA NA NA hsa-miR-140-5p SNRPN -0.755971041589807 9.68060922934542e-14 -0.145756373517547 0.194678771019692 miRanda -0.193593945315216 2.06215818420552e-07 NA NA NA hsa-miR-140-5p SNTN -0.755971041589807 9.68060922934542e-14 1.64439187414873 7.49229363767271e-09 miRanda -0.788869497277224 5.19515646206702e-17 NA NA NA hsa-miR-194-5p SNX29 0.467781870340114 1.0386810618625e-07 -0.597111512317845 3.97672045101413e-19 miRNATAP -0.138580183148862 1.53665417851967e-07 NA NA NA hsa-miR-194-5p SOCS2 0.467781870340114 1.0386810618625e-07 -1.85803882323019 1.27461377734762e-27 miRNAWalker2_validate;miRTarBase;miRNATAP -0.267533169196439 9.55649717737723e-05 22102710 Functional studies indicated that CDKN1A/p21 and SOCS2 expression is directly regulated by miR-20a/-20b and miR-194 respectively; miR-20a/b and miR-194 target CDKN1A and SOCS2 in follicular lymphoma potentially contributing to tumor cell proliferation and survival poor survival lymphoma hsa-miR-140-5p SORCS1 -0.755971041589807 9.68060922934542e-14 -1.17464209650385 0.00185228663810649 miRanda -0.321392838605893 0.0109375852410087 NA NA NA hsa-miR-140-5p SOX2 -0.755971041589807 9.68060922934542e-14 1.62824878642595 1.83270623627945e-06 miRNAWalker2_validate;miRTarBase -0.260852621786827 0.0229665657143227 23060440;25426255 We found that the stem cell self-renewal regulator SOX2 is a novel target of miR-140 and that this miR-140/SOX2 pathway critically regulates breast tumor-initiating cell survival providing a new link between ERα signaling and breast cancer stem cell maintenance;miR-140 plays an important tumor suppressive role in the Wnt SOX2 and SOX9 stem cell regulator pathways poor survival; breast cancer;breast cancer hsa-miR-34a-5p SOX2 0.129201805242403 0.133261654068224 1.62824878642595 1.83270623627945e-06 miRNAWalker2_validate;miRTarBase -0.278027267640546 0.0437892548060246 NA NA NA hsa-miR-194-5p SOX5 0.467781870340114 1.0386810618625e-07 -2.72079957365634 5.8401556767149e-39 miRNAWalker2_validate;miRTarBase -0.207387242964335 0.0149928699250761 NA NA NA hsa-miR-34a-5p SOX6 0.129201805242403 0.133261654068224 -2.37114135592246 4.35252660248189e-25 miRNATAP -0.425548311852312 6.61473113909632e-06 NA NA NA hsa-miR-140-5p SPAG1 -0.755971041589807 9.68060922934542e-14 1.21536502852341 1.21867718052225e-27 miRanda -0.181152521734309 2.29663683045185e-06 NA NA NA hsa-miR-194-5p SPOCK3 0.467781870340114 1.0386810618625e-07 -2.9791873535921 4.19634385238139e-30 miRNATAP -0.358503838996602 0.000679825759667293 NA NA NA hsa-miR-194-5p SPRED1 0.467781870340114 1.0386810618625e-07 -0.73987992932487 1.32055673934219e-15 miRNATAP -0.144803147932375 7.5566668425542e-05 NA NA NA hsa-miR-34a-5p SPTBN1 0.129201805242403 0.133261654068224 -1.9362598712969 2.27075223607576e-99 miRNAWalker2_validate -0.143349271369707 0.000559389321162466 NA NA NA hsa-miR-140-5p SRCAP -0.755971041589807 9.68060922934542e-14 0.312681764149912 1.03687865107893e-09 MirTarget;PITA;miRanda;miRNATAP -0.113185877692682 3.00089283695161e-11 NA NA NA hsa-miR-140-5p SRP14 -0.755971041589807 9.68060922934542e-14 0.186219806992087 0.000507691573405291 miRanda -0.106497860392912 1.85835603081001e-09 NA NA NA hsa-miR-140-5p SRP9 -0.755971041589807 9.68060922934542e-14 0.917873533109478 3.26551316666509e-45 miRanda -0.149632028222319 4.3476334449742e-11 NA NA NA hsa-miR-140-5p ST6GAL2 -0.755971041589807 9.68060922934542e-14 1.15906949574813 1.52522181723685e-09 MirTarget;miRanda -0.167108161597506 0.00980366717835481 NA NA NA hsa-miR-34a-5p STAC2 0.129201805242403 0.133261654068224 -3.92462248766626 1.69039671507241e-20 miRNATAP -0.393547413230739 0.0237347789462646 NA NA NA hsa-miR-194-5p STAT5B 0.467781870340114 1.0386810618625e-07 -1.26603570026736 3.18742679965819e-62 miRNATAP -0.122789240886661 0.000120774595899818 NA NA NA hsa-miR-140-5p STC2 -0.755971041589807 9.68060922934542e-14 -0.0885452840851233 0.737465962738353 PITA;miRanda -0.607907066484541 2.90731054848937e-12 NA NA NA hsa-miR-140-5p STK16 -0.755971041589807 9.68060922934542e-14 0.402504151002991 9.90775556523305e-12 miRanda -0.15626399755489 1.62975445089963e-15 NA NA NA hsa-miR-34a-5p STK38L 0.129201805242403 0.133261654068224 -0.0759878885375915 0.42193889940826 MirTarget -0.104794927277798 0.00569858648206235 NA NA NA hsa-miR-140-5p STON2 -0.755971041589807 9.68060922934542e-14 -0.545148996478914 0.000718861252871896 miRanda -0.168361129584486 0.00178858236381325 NA NA NA hsa-miR-140-5p STX1A -0.755971041589807 9.68060922934542e-14 1.57261944326317 3.66317167496333e-44 miRanda -0.250614120088489 2.02998942020227e-10 NA NA NA hsa-miR-34a-5p STX1B 0.129201805242403 0.133261654068224 -0.750600392365291 3.51549659031347e-07 mirMAP -0.129852677602812 0.0292635061050549 NA NA NA hsa-miR-140-5p SULT1A1 -0.755971041589807 9.68060922934542e-14 0.0830414760927862 0.527522502286307 miRanda -0.346852622616667 8.50386235310878e-16 NA NA NA hsa-miR-140-5p SUSD3 -0.755971041589807 9.68060922934542e-14 1.6591493875823 1.52993112632002e-10 MirTarget;miRanda -0.647447988573608 6.09928741123394e-14 NA NA NA hsa-miR-140-5p SYCP2 -0.755971041589807 9.68060922934542e-14 1.05161487459865 2.402892169769e-08 miRanda -0.285028160925473 6.49329717118098e-06 NA NA NA hsa-miR-140-5p SYMPK -0.755971041589807 9.68060922934542e-14 0.54015554865495 5.5762764604845e-18 miRanda -0.152834978277962 3.2365324728649e-13 NA NA NA hsa-miR-34a-5p SYT1 0.129201805242403 0.133261654068224 0.523451617487376 0.0893148223385868 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.250248705456957 0.0431763694455241 NA NA NA hsa-miR-34a-5p TAF4B 0.129201805242403 0.133261654068224 -1.04392753121047 2.11654634898376e-13 miRNATAP -0.237310687971241 3.96133914695322e-05 NA NA NA hsa-miR-140-5p TANC2 -0.755971041589807 9.68060922934542e-14 0.645784897636979 5.11106873490809e-07 miRanda;miRNATAP -0.17292072419479 5.9955535636937e-05 NA NA NA hsa-miR-194-5p TAOK1 0.467781870340114 1.0386810618625e-07 -1.02699433731773 5.06740042441332e-08 miRNATAP -0.18570815210405 0.012107655810652 NA NA NA hsa-miR-34a-5p TBC1D16 0.129201805242403 0.133261654068224 -0.318134709463815 0.000815367768719466 mirMAP -0.108609534043346 0.0044512749374307 NA NA NA hsa-miR-34a-5p TBC1D2B 0.129201805242403 0.133261654068224 -0.710483100609729 1.38018429843516e-25 MirTarget -0.104377897575302 0.00019523996639105 NA NA NA hsa-miR-140-5p TBC1D3H -0.755971041589807 9.68060922934542e-14 0.675826851188591 3.43230960919642e-05 miRanda -0.199369810453259 0.000260441694525799 NA NA NA hsa-miR-140-5p TBCA -0.755971041589807 9.68060922934542e-14 0.50546628071876 1.35040310218574e-14 miRanda -0.112384760105547 3.73111992051758e-07 NA NA NA hsa-miR-140-5p TCF3 -0.755971041589807 9.68060922934542e-14 0.956078144144414 4.0063119417161e-35 miRanda -0.132692336157928 7.32919303228894e-07 NA NA NA hsa-miR-194-5p TDRD9 0.467781870340114 1.0386810618625e-07 -1.30844523360363 5.64077428556261e-07 MirTarget -0.397866381238293 0.000100745505422986 NA NA NA hsa-miR-194-5p TEAD1 0.467781870340114 1.0386810618625e-07 -1.39931853829988 3.11111186209198e-44 MirTarget -0.168216467247601 4.36851163511298e-05 NA NA NA hsa-miR-140-5p TEKT1 -0.755971041589807 9.68060922934542e-14 0.32195535402764 0.271754013262093 miRanda -0.305223028441127 0.00178489018026974 NA NA NA hsa-miR-140-5p TEX9 -0.755971041589807 9.68060922934542e-14 0.0509689822456678 0.700082142899211 miRanda -0.100620950420701 0.0226814611411705 NA NA NA hsa-miR-140-5p TFR2 -0.755971041589807 9.68060922934542e-14 3.0930506405839 2.01632945058891e-43 miRanda -0.186803822919376 0.0180111294468262 NA NA NA hsa-miR-34a-5p TGFBR3 0.129201805242403 0.133261654068224 -3.32389218515653 1.82193869897655e-62 miRNATAP -0.3386975349782 8.74095048637456e-05 NA NA NA hsa-miR-152-3p TGIF2 -0.26603867075042 0.0063861560676033 0.381752628831196 2.37116884002192e-05 MirTarget -0.193483211152577 1.0166796108524e-09 NA NA NA hsa-miR-140-5p THSD4 -0.755971041589807 9.68060922934542e-14 0.0741740305225802 0.740086284221452 miRanda -0.591738826704701 7.13345158446049e-16 NA NA NA hsa-miR-140-5p TIGD6 -0.755971041589807 9.68060922934542e-14 0.10320508240119 0.0857844194246162 miRanda -0.149869364524654 2.87063981422556e-14 NA NA NA hsa-miR-194-5p TJP1 0.467781870340114 1.0386810618625e-07 -0.765496503458334 3.43269584339806e-25 miRNATAP -0.137689745298826 2.99437887537571e-06 NA NA NA hsa-miR-194-5p TLN2 0.467781870340114 1.0386810618625e-07 -1.83784711672792 1.84067578710874e-73 miRNAWalker2_validate;miRTarBase;miRNATAP -0.198554235233813 4.1593219233349e-06 NA NA NA hsa-miR-140-5p TMEM115 -0.755971041589807 9.68060922934542e-14 0.330223714800447 2.51515043777307e-07 miRanda -0.189154579926955 2.31697811881804e-19 NA NA NA hsa-miR-140-5p TMEM144 -0.755971041589807 9.68060922934542e-14 -0.222974365100777 0.0453860472712897 miRanda -0.177361498647211 1.66449143320569e-06 NA NA NA hsa-miR-34a-5p TMEM164 0.129201805242403 0.133261654068224 0.0626537796951929 0.532803987814265 MirTarget -0.123336005213473 0.0021662274382747 NA NA NA hsa-miR-140-5p TMEM177 -0.755971041589807 9.68060922934542e-14 0.795775940297885 1.42939917603357e-32 MirTarget;miRanda -0.136736655187974 2.95027885417142e-09 NA NA NA hsa-miR-140-5p TMEM191A -0.755971041589807 9.68060922934542e-14 1.53632741125831 1.07170490259332e-30 miRanda -0.142783480910255 0.000148275019725646 NA NA NA hsa-miR-194-5p TMEM200A 0.467781870340114 1.0386810618625e-07 -0.0949912678559239 0.458716822058119 MirTarget -0.277070839846779 2.22158754319398e-08 NA NA NA hsa-miR-194-5p TMEM26 0.467781870340114 1.0386810618625e-07 -0.275027081500498 0.2289426344356 MirTarget -0.272728841259714 0.0021707208182055 NA NA NA hsa-miR-194-5p TMEM43 0.467781870340114 1.0386810618625e-07 -0.763185893816313 4.24636950864574e-43 MirTarget;miRNATAP -0.11479362875513 3.83613833591313e-07 NA NA NA hsa-miR-152-3p TMEM54 -0.26603867075042 0.0063861560676033 1.3364561786548 4.50284995105945e-41 MirTarget -0.203890424074188 2.74411032645636e-08 NA NA NA hsa-miR-140-5p TMEM91 -0.755971041589807 9.68060922934542e-14 -0.378492615423069 0.000756396958743798 miRanda -0.131459574630302 0.000461533185870745 NA NA NA hsa-miR-140-5p TNFRSF14 -0.755971041589807 9.68060922934542e-14 0.0770396494033028 0.449713588021391 miRanda -0.125221069038779 0.000222586859001059 NA NA NA hsa-miR-152-3p TNIP2 -0.26603867075042 0.0063861560676033 0.50190943651082 8.86186010390026e-11 MirTarget -0.134687406923655 9.15482467468808e-07 NA NA NA hsa-miR-140-5p TOM1L1 -0.755971041589807 9.68060922934542e-14 0.704932194727521 7.70954564884351e-09 miRanda -0.254107179963258 4.39644204347402e-10 NA NA NA hsa-miR-140-5p TOX3 -0.755971041589807 9.68060922934542e-14 1.00432770054387 0.00104894619135282 miRanda -0.673352686342097 3.23528599030389e-11 NA NA NA hsa-miR-140-5p TP53I11 -0.755971041589807 9.68060922934542e-14 0.760507593043101 2.5492467701477e-19 mirMAP -0.239789710597126 2.61003702895535e-17 NA NA NA hsa-miR-140-5p TP53INP1 -0.755971041589807 9.68060922934542e-14 0.722610414665271 5.79158974462484e-11 PITA;miRanda -0.26034305116086 1.47722939768224e-12 NA NA NA hsa-miR-140-5p TPCN1 -0.755971041589807 9.68060922934542e-14 -0.534516429245345 1.12249084682121e-14 MirTarget;miRNATAP -0.122687810067634 1.41153612313688e-07 NA NA NA hsa-miR-140-5p TRAM1L1 -0.755971041589807 9.68060922934542e-14 0.238455332093468 0.0323872036595285 miRanda -0.176547870773043 1.87529061239254e-06 NA NA NA hsa-miR-194-5p TRIM23 0.467781870340114 1.0386810618625e-07 -0.683201005926275 2.66644008303317e-19 MirTarget -0.151937933925705 4.49102466708226e-07 26221053 Transcripts encoding tripartite motif containing 23 TRIM23 a ubiquitin ligase involved in NF-κB activation and chromosome 21 open reading frame 91 C21ORF91 a protein of unknown function were identified as direct targets of miR-194 in HCC cells; knocking down either protein decreased the activity of a luciferase NF-κB reporter liver cancer hsa-miR-140-5p TROAP -0.755971041589807 9.68060922934542e-14 4.04714894948444 4.2079403106802e-101 miRanda -0.273324208105598 0.00013999135324352 NA NA NA hsa-miR-34a-5p TSHZ2 0.129201805242403 0.133261654068224 -3.17391923475675 1.40654093537148e-60 miRNATAP -0.348895376632962 2.93429261061375e-05 NA NA NA hsa-miR-34a-5p TSPAN11 0.129201805242403 0.133261654068224 -1.45285413814232 3.99090114003723e-22 mirMAP -0.194403194671151 0.00166867056228538 NA NA NA hsa-miR-140-5p TSPAN17 -0.755971041589807 9.68060922934542e-14 1.0082851297073 6.46885226862221e-49 miRanda -0.168125723427873 2.56353418001026e-12 NA NA NA hsa-miR-140-5p TTC23L -0.755971041589807 9.68060922934542e-14 0.270118991431474 0.130649122178966 miRanda -0.408533130221129 4.17653822334226e-12 NA NA NA hsa-miR-140-5p TTC39A -0.755971041589807 9.68060922934542e-14 1.75127730029576 1.95458566556964e-23 miRanda -0.658101830408544 1.22510198143661e-29 NA NA NA hsa-miR-140-5p TTLL9 -0.755971041589807 9.68060922934542e-14 0.722416535324153 2.54630996762832e-05 miRanda -0.451025855838825 1.58307106422235e-15 NA NA NA hsa-miR-140-5p TXNDC17 -0.755971041589807 9.68060922934542e-14 1.03223729641314 1.50245845188525e-40 miRanda -0.186557201632587 3.59316827894088e-12 NA NA NA hsa-miR-34a-5p TXNIP 0.129201805242403 0.133261654068224 -2.1278383158488 8.14661112419651e-76 miRNAWalker2_validate -0.188001155068047 0.000220784877568425 NA NA NA hsa-miR-140-5p TYRP1 -0.755971041589807 9.68060922934542e-14 2.17324372285648 2.09317741500386e-12 miRanda -0.300700500207697 0.0040621842145788 NA NA NA hsa-miR-140-5p UBQLN4 -0.755971041589807 9.68060922934542e-14 0.982563860011317 3.28783474202975e-45 miRanda -0.114142965147192 3.07205211193518e-06 NA NA NA hsa-miR-140-5p UBXN10 -0.755971041589807 9.68060922934542e-14 0.120437741779328 0.568915664613989 mirMAP -0.544676036022717 4.31337460425306e-15 NA NA NA hsa-miR-152-3p UCP3 -0.26603867075042 0.0063861560676033 -0.118198378700977 0.241286299485856 MirTarget -0.12161617423532 0.000610420053089352 NA NA NA hsa-miR-34a-5p UCP3 0.129201805242403 0.133261654068224 -0.118198378700977 0.241286299485856 MirTarget -0.137068307707529 0.000686922122113849 NA NA NA hsa-miR-140-5p UHRF1 -0.755971041589807 9.68060922934542e-14 3.81726615419535 1.18929553786585e-111 miRanda -0.312182921396835 1.5829584228414e-06 NA NA NA hsa-miR-140-5p VSTM2A -0.755971041589807 9.68060922934542e-14 2.08703311616969 4.93222482734593e-05 miRanda -0.951304042775792 2.75994694754984e-08 NA NA NA hsa-miR-140-5p WDR93 -0.755971041589807 9.68060922934542e-14 -0.0411151219218292 0.814721887704969 miRanda -0.356256990924398 8.16419405056188e-10 NA NA NA hsa-miR-140-5p WFDC2 -0.755971041589807 9.68060922934542e-14 0.474292404722283 0.154612295074134 miRanda -0.296232512086896 0.00775150137870009 NA NA NA hsa-miR-140-5p WNK4 -0.755971041589807 9.68060922934542e-14 0.474443927728855 0.176773171166687 miRanda;miRNATAP -0.684836859609355 3.92001746817171e-09 NA NA NA hsa-miR-194-5p WTIP 0.467781870340114 1.0386810618625e-07 -0.673697271502645 8.0399213972999e-08 mirMAP -0.108731858285965 0.0273945940351866 NA NA NA hsa-miR-34a-5p WTIP 0.129201805242403 0.133261654068224 -0.673697271502645 8.0399213972999e-08 mirMAP -0.131580463765731 0.00952351345758211 NA NA NA hsa-miR-140-5p XRCC3 -0.755971041589807 9.68060922934542e-14 0.734264365065646 9.3532318956229e-17 mirMAP -0.141273892502662 2.31508871182716e-06 NA NA NA hsa-miR-34a-5p XYLT1 0.129201805242403 0.133261654068224 -0.871966257661826 2.6739267034943e-11 MirTarget;miRNATAP -0.162023559465777 0.00228029159172534 NA NA NA hsa-miR-140-5p ZBTB41 -0.755971041589807 9.68060922934542e-14 0.554907216032451 1.50686924466456e-08 miRanda -0.124361073803316 0.000158136399182776 NA NA NA hsa-miR-140-5p ZBTB7A -0.755971041589807 9.68060922934542e-14 0.205523692750221 0.000138883817833896 miRanda -0.142952558696926 6.88395743803402e-16 NA NA NA hsa-miR-140-5p ZDHHC11 -0.755971041589807 9.68060922934542e-14 0.205266125708579 0.207209401317671 miRanda -0.397573054313781 1.13671247077479e-13 NA NA NA hsa-miR-34a-5p ZDHHC15 0.129201805242403 0.133261654068224 -1.79355508284452 1.31588141500882e-28 MirTarget -0.147486771938705 0.0282248408181249 NA NA NA hsa-miR-34a-5p ZDHHC17 0.129201805242403 0.133261654068224 -0.866022836216911 6.86139577858733e-36 MirTarget;miRNATAP -0.116567034271263 5.58224812095332e-05 NA NA NA hsa-miR-152-3p ZDHHC23 -0.26603867075042 0.0063861560676033 0.639837826532268 9.42867014596828e-12 MirTarget -0.127674584057276 0.000134480190009752 NA NA NA hsa-miR-194-5p ZEB1 0.467781870340114 1.0386810618625e-07 -1.20177694006781 1.58231961737395e-22 miRNATAP -0.324047924162725 2.84415855947526e-11 NA NA NA hsa-miR-194-5p ZFHX3 0.467781870340114 1.0386810618625e-07 -0.348999974902257 0.000181853915066663 MirTarget;miRNATAP -0.156864842398398 1.5361215866087e-05 NA NA NA hsa-miR-194-5p ZFHX4 0.467781870340114 1.0386810618625e-07 -1.53229883683245 2.36314851813226e-21 MirTarget;miRNATAP -0.357277837970819 2.461717491273e-08 NA NA NA hsa-miR-34a-5p ZFHX4 0.129201805242403 0.133261654068224 -1.53229883683245 2.36314851813226e-21 MirTarget;miRNATAP -0.169461312266869 0.0108102549259054 NA NA NA hsa-miR-34a-5p ZHX2 0.129201805242403 0.133261654068224 -0.0211599680772165 0.765558755455652 MirTarget -0.105606730088637 0.000194610331621197 NA NA NA hsa-miR-140-5p ZKSCAN2 -0.755971041589807 9.68060922934542e-14 0.131614771066059 0.078440577623845 miRanda -0.113863705623454 4.53211224474368e-06 NA NA NA hsa-miR-140-5p ZMYND8 -0.755971041589807 9.68060922934542e-14 0.465559261983897 2.5884513985959e-08 miRanda -0.127792128263213 5.04822308202727e-06 NA NA NA hsa-miR-194-5p ZNF25 0.467781870340114 1.0386810618625e-07 -0.915091884555666 2.34108696708142e-41 miRNATAP -0.143055659918459 2.31319474121369e-07 NA NA NA hsa-miR-34a-5p ZNF281 0.129201805242403 0.133261654068224 0.313231399072104 0.0298230922775962 MirTarget;miRNATAP -0.16396767468212 0.00459987864471523 NA NA NA hsa-miR-152-3p ZNF3 -0.26603867075042 0.0063861560676033 0.358240094723058 6.93214679737173e-14 MirTarget -0.128445560033987 2.16083599356508e-14 NA NA NA hsa-miR-34a-5p ZNF304 0.129201805242403 0.133261654068224 -0.231648905904749 0.00275641418971822 miRNATAP -0.125037852533268 5.42583762688554e-05 NA NA NA hsa-miR-140-5p ZNF346 -0.755971041589807 9.68060922934542e-14 0.185828991787589 0.000266073908177487 miRanda -0.103191783363714 9.19991289821442e-10 NA NA NA hsa-miR-140-5p ZNF500 -0.755971041589807 9.68060922934542e-14 0.371749530394336 1.31282654910857e-08 miRanda -0.216199977144359 4.76839733555007e-24 NA NA NA hsa-miR-34a-5p ZNF512 0.129201805242403 0.133261654068224 -0.299390933309408 8.67551657148122e-05 miRNATAP -0.113171020205434 0.000218714879157516 NA NA NA hsa-miR-34a-5p ZNF532 0.129201805242403 0.133261654068224 -0.486598759081946 3.90195954090326e-08 miRNATAP -0.105069857286537 0.00330721470538643 NA NA NA hsa-miR-34a-5p ZNF551 0.129201805242403 0.133261654068224 -0.412038945252145 0.000180020113372829 MirTarget;miRNATAP -0.206713508924214 2.72418460479193e-06 NA NA NA hsa-miR-140-5p ZNF606 -0.755971041589807 9.68060922934542e-14 0.323430477299799 0.000151450350485159 miRanda -0.154331886268196 5.38474472662987e-08 NA NA NA hsa-miR-34a-5p ZNF641 0.129201805242403 0.133261654068224 -0.634238399739506 4.03050324313056e-09 MirTarget -0.211553540538914 1.10816403121495e-06 NA NA NA hsa-miR-140-5p ZNF689 -0.755971041589807 9.68060922934542e-14 -0.187666926528026 0.172159706978396 miRanda -0.134723996740337 0.00329949847473932 NA NA NA hsa-miR-140-5p ZNF710 -0.755971041589807 9.68060922934542e-14 0.646959318907931 4.14401482289693e-15 miRNATAP -0.111520740645671 6.36527463282405e-05 NA NA NA hsa-miR-152-3p ZNF784 -0.26603867075042 0.0063861560676033 0.158451026732544 0.0499730374026247 MirTarget -0.148187476619635 1.65862666853671e-07 NA NA NA