miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106a-5p BMP2 2.48882002962836 1.99757727374521e-12 -1.4585556992146 0.00276269620457527 miRNATAP -0.13733219575815 0.0353378641266495 NA NA NA hsa-miR-17-5p BMP2 3.2710598467455 9.93128340539455e-27 -1.4585556992146 0.00276269620457527 TargetScan -0.179082884567471 0.0139285781243937 NA NA NA hsa-miR-20a-5p BMP2 3.15577933619191 4.19753346442454e-25 -1.4585556992146 0.00276269620457527 miRNATAP -0.172086381139174 0.0189386691781264 NA NA NA hsa-miR-3065-5p BMP2 2.74629919868982 1.86846589298284e-08 -1.4585556992146 0.00276269620457527 mirMAP -0.271238334102083 2.81263836360285e-06 NA NA NA hsa-miR-335-3p BMP2 3.08791651139852 5.31309869723517e-12 -1.4585556992146 0.00276269620457527 mirMAP -0.11624777686982 0.0240386766712432 NA NA NA hsa-miR-106a-5p BMP7 2.48882002962836 1.99757727374521e-12 -1.77720755920917 0.028758021459053 mirMAP -0.213107626919806 0.0497769925486375 NA NA NA hsa-miR-17-5p BMP7 3.2710598467455 9.93128340539455e-27 -1.77720755920917 0.028758021459053 mirMAP -0.30309517063183 0.0123654622246275 NA NA NA hsa-miR-20b-5p BMP7 2.07706563022469 1.10107236083433e-05 -1.77720755920917 0.028758021459053 mirMAP -0.167918446086084 0.0420527528441079 NA NA NA hsa-miR-338-3p BMP7 0.453166438193782 0.144583389707558 -1.77720755920917 0.028758021459053 miRanda -0.411479827858547 0.00118108686362591 NA NA NA hsa-miR-342-3p BMP7 1.49115144672245 1.43879249744621e-07 -1.77720755920917 0.028758021459053 miRNAWalker2_validate;miRTarBase;miRanda -0.564549946965806 3.57247612956533e-05 NA NA NA hsa-miR-362-3p BMP7 2.0756816987665 3.89026064579331e-12 -1.77720755920917 0.028758021459053 miRanda -0.30784906106111 0.0207029789815096 NA NA NA hsa-miR-450b-5p BMP7 1.69244418548325 1.68064054148881e-10 -1.77720755920917 0.028758021459053 mirMAP -0.312735833754277 0.0324802930889376 NA NA NA hsa-miR-28-5p CTNNB1 0.230152919654905 0.0742909586754846 -0.220922161177096 0.11826020711692 miRanda -0.182072912507331 0.000829385072717343 NA NA NA hsa-miR-15a-5p EPB41L5 2.34669284378787 1.69544424500258e-23 -0.613962325919019 0.001858457272644 MirTarget -0.109946763271783 0.00452899966676662 NA NA NA hsa-miR-26b-5p EPB41L5 0.885393662798425 3.2116297961629e-06 -0.613962325919019 0.001858457272644 mirMAP -0.103554029116114 0.0402137076946522 NA NA NA hsa-miR-139-5p FAM83D -1.52606598644743 1.20474151350665e-08 0.489739919886805 0.0914401636745924 miRanda -0.127477591893435 0.0137660511132003 NA NA NA hsa-miR-429 FAM83D 4.48815175680773 2.44117492218206e-17 0.489739919886805 0.0914401636745924 miRanda -0.128849987303415 2.89649716657933e-07 NA NA NA hsa-let-7a-3p FGFR2 1.42015538786275 7.03375209382654e-13 -1.10510536599184 0.0128825317606034 miRNATAP -0.403668699840633 0.000151473399712384 NA NA NA hsa-let-7b-3p FGFR2 0.868207752019623 1.30460056774366e-05 -1.10510536599184 0.0128825317606034 mirMAP;miRNATAP -0.309687251123528 0.00423048135274253 NA NA NA hsa-miR-107 FGFR2 1.30977326593435 1.30372468603965e-11 -1.10510536599184 0.0128825317606034 PITA;miRanda -0.398153526215925 0.00027439034373613 NA NA NA hsa-miR-126-5p FGFR2 0.895338176458417 2.33372756450713e-05 -1.10510536599184 0.0128825317606034 mirMAP;miRNATAP -0.403452572621652 6.82252178653857e-05 NA NA NA hsa-miR-146b-5p FGFR2 1.75587235896724 1.15724631266659e-07 -1.10510536599184 0.0128825317606034 miRanda -0.146244445164253 0.022817620173302 NA NA NA hsa-miR-186-5p FGFR2 1.47445398888668 3.0781726595413e-15 -1.10510536599184 0.0128825317606034 miRNAWalker2_validate -0.471854892718397 2.53033898213571e-05 NA NA NA hsa-miR-193a-3p FGFR2 1.60460546928078 2.86169793322984e-07 -1.10510536599184 0.0128825317606034 miRanda -0.184992348766107 0.00659604280779591 NA NA NA hsa-miR-19b-1-5p FGFR2 2.57951428759379 4.31576118703427e-20 -1.10510536599184 0.0128825317606034 miRNAWalker2_validate;miRTarBase -0.4345309219133 4.77765562006864e-09 NA NA NA hsa-miR-324-5p FGFR2 2.95683728155095 1.32960514360912e-20 -1.10510536599184 0.0128825317606034 miRanda -0.24680525694008 0.000127710806173706 NA NA NA hsa-miR-338-3p FGFR2 0.453166438193782 0.144583389707558 -1.10510536599184 0.0128825317606034 miRanda;miRNATAP -0.263518769420772 0.000141261313872914 NA NA NA hsa-miR-423-3p FGFR2 2.57855385753676 9.19765570228097e-24 -1.10510536599184 0.0128825317606034 PITA;miRNATAP -0.233949308012158 0.00330874395567353 NA NA NA hsa-miR-590-3p FGFR2 2.59289455139753 1.03200520972022e-21 -1.10510536599184 0.0128825317606034 miRanda -0.311141579023723 6.00872154446622e-05 NA NA NA hsa-miR-628-5p FGFR2 0.799263053510813 2.28892357418044e-05 -1.10510536599184 0.0128825317606034 PITA;miRNATAP -0.568329203893148 5.54144600332728e-07 NA NA NA hsa-miR-130b-3p FOXF2 3.5350292994509 1.73934183852569e-27 -1.01140437164378 0.0089128131433903 miRNATAP -0.111927000474606 0.0385945280592391 NA NA NA hsa-miR-139-5p GSK3B -1.52606598644743 1.20474151350665e-08 0.406268283461383 0.000508906658360755 mirMAP -0.100160771461377 1.20519675407331e-06 NA NA NA hsa-let-7a-3p HGF 1.42015538786275 7.03375209382654e-13 -2.96833708580794 2.21214820634191e-07 mirMAP -0.542810606112975 9.43474905006386e-05 NA NA NA hsa-let-7b-3p HGF 0.868207752019623 1.30460056774366e-05 -2.96833708580794 2.21214820634191e-07 mirMAP -0.566084083307672 5.71312900566914e-05 NA NA NA hsa-let-7f-1-3p HGF 1.55054488387679 7.31326775537952e-11 -2.96833708580794 2.21214820634191e-07 mirMAP -0.343222022733725 0.00407354838842982 NA NA NA hsa-miR-126-5p HGF 0.895338176458417 2.33372756450713e-05 -2.96833708580794 2.21214820634191e-07 mirMAP -0.30252476535825 0.0230197315111662 NA NA NA hsa-miR-129-5p HGF -0.524170159980738 0.222582956006346 -2.96833708580794 2.21214820634191e-07 mirMAP -0.176315710478523 0.00827877952568297 NA NA NA hsa-miR-141-3p HGF 5.02396127982626 2.19224509139725e-24 -2.96833708580794 2.21214820634191e-07 MirTarget;TargetScan -0.676636907580645 1.12497659260577e-44 NA NA NA hsa-miR-181a-5p HGF 2.29556023480783 1.8138457900616e-21 -2.96833708580794 2.21214820634191e-07 mirMAP -0.725020652043404 2.96259222943239e-11 NA NA NA hsa-miR-181b-5p HGF 2.49307679431293 3.92829250217627e-20 -2.96833708580794 2.21214820634191e-07 mirMAP -0.706743272553437 2.55576874895847e-13 NA NA NA hsa-miR-181c-5p HGF 1.58587920618301 1.57506918816933e-10 -2.96833708580794 2.21214820634191e-07 mirMAP -0.655855093153665 2.2633028663108e-09 NA NA NA hsa-miR-200a-3p HGF 4.59434485520731 6.38952518573476e-18 -2.96833708580794 2.21214820634191e-07 MirTarget -0.565686401356116 7.92905519776232e-34 NA NA NA hsa-miR-203a-3p HGF 3.12352008343999 9.49391438647189e-07 -2.96833708580794 2.21214820634191e-07 MirTarget -0.307285226038045 3.93961477705831e-13 NA NA NA hsa-miR-224-3p HGF 1.87536386559317 6.15140969394846e-05 -2.96833708580794 2.21214820634191e-07 mirMAP -0.425091238537773 2.95664734683986e-12 NA NA NA hsa-miR-26b-5p HGF 0.885393662798425 3.2116297961629e-06 -2.96833708580794 2.21214820634191e-07 MirTarget;miRNATAP -0.860917332821866 3.45908003051971e-09 NA NA NA hsa-miR-30b-5p HGF 0.800822374912712 0.000133601914525413 -2.96833708580794 2.21214820634191e-07 mirMAP -0.745493458613655 1.87319496040024e-08 NA NA NA hsa-miR-30c-5p HGF 0.778774633108 0.000285599212429136 -2.96833708580794 2.21214820634191e-07 mirMAP -0.865812342797699 1.59173376397441e-11 NA NA NA hsa-miR-30d-5p HGF 0.675423997639582 0.00270618816039773 -2.96833708580794 2.21214820634191e-07 mirMAP -1.14363195060416 9.73383073509946e-22 NA NA NA hsa-miR-30e-5p HGF 1.23904909539663 1.35561917122157e-09 -2.96833708580794 2.21214820634191e-07 mirMAP -1.43246567275328 1.85577963409756e-29 NA NA NA hsa-miR-335-3p HGF 3.08791651139852 5.31309869723517e-12 -2.96833708580794 2.21214820634191e-07 mirMAP -0.296203494255056 9.94228604078741e-07 NA NA NA hsa-miR-33a-3p HGF 1.72765312072219 1.51784443453521e-07 -2.96833708580794 2.21214820634191e-07 mirMAP -0.709152405531059 2.95855303843078e-15 NA NA NA hsa-miR-34c-5p HGF 2.07190852984647 7.35776320806257e-08 -2.96833708580794 2.21214820634191e-07 miRanda -0.179064697968714 0.0198975045718808 NA NA NA hsa-miR-421 HGF 1.17791565395543 6.78526676976629e-06 -2.96833708580794 2.21214820634191e-07 miRanda -0.423367559608824 7.10463304822239e-05 NA NA NA hsa-miR-429 HGF 4.48815175680773 2.44117492218206e-17 -2.96833708580794 2.21214820634191e-07 miRanda -0.520793016805242 9.95726908305676e-28 NA NA NA hsa-miR-582-5p HGF 0.609226359812689 0.032988717891497 -2.96833708580794 2.21214820634191e-07 PITA -0.41813369111985 1.98992264527824e-05 NA NA NA hsa-miR-590-3p HGF 2.59289455139753 1.03200520972022e-21 -2.96833708580794 2.21214820634191e-07 miRanda;mirMAP -0.643510815709232 1.09614685120259e-10 NA NA NA hsa-miR-590-5p HGF 3.18300989862077 2.06813568597893e-26 -2.96833708580794 2.21214820634191e-07 miRanda -0.712648418249155 4.67151690440208e-16 NA NA NA hsa-miR-651-5p HGF 2.32951837918862 1.62508965949028e-11 -2.96833708580794 2.21214820634191e-07 MirTarget -0.876408480048342 2.87757604471444e-25 NA NA NA hsa-miR-7-1-3p HGF 1.84950311431067 1.25300363397654e-13 -2.96833708580794 2.21214820634191e-07 mirMAP -0.580271470067749 8.96109537411397e-08 NA NA NA hsa-miR-944 HGF 2.91186649218281 1.31574753528144e-06 -2.96833708580794 2.21214820634191e-07 mirMAP -0.408051827291836 3.7779107870685e-19 NA NA NA hsa-miR-106b-3p HIF1A 1.74115042407425 7.96524575137272e-14 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate -0.115876573349366 0.01114041942823 NA NA NA hsa-miR-106b-5p HIF1A 2.46782146831112 1.36171495805632e-23 -0.0887083952652183 0.694448347585856 MirTarget -0.22506470406352 5.67731754915871e-08 NA NA NA hsa-miR-107 HIF1A 1.30977326593435 1.30372468603965e-11 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate;miRTarBase;miRanda -0.123422589068387 0.0264755744668062 NA NA NA hsa-miR-151a-3p HIF1A 1.24018761527407 1.08839919675408e-07 -0.0887083952652183 0.694448347585856 MirTarget -0.16533909856988 0.000338305910074446 NA NA NA hsa-miR-20a-5p HIF1A 3.15577933619191 4.19753346442454e-25 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate;miRTarBase;MirTarget -0.115406855575695 0.000600547799598935 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-28-5p HIF1A 0.230152919654905 0.0742909586754846 -0.0887083952652183 0.694448347585856 miRanda -0.410823482574077 2.0450455286232e-06 NA NA NA hsa-miR-330-3p HIF1A 0.876747334239085 0.00073709016089703 -0.0887083952652183 0.694448347585856 MirTarget;PITA -0.100136266436928 0.0170482873133228 NA NA NA hsa-miR-361-5p HIF1A 0.971859117235239 5.30236555707088e-09 -0.0887083952652183 0.694448347585856 miRanda -0.240248110278126 0.00022502129165918 NA NA NA hsa-miR-660-5p HIF1A 1.82692095272076 1.92040083607196e-13 -0.0887083952652183 0.694448347585856 MirTarget -0.138381785632354 0.00119715434144136 NA NA NA hsa-miR-93-5p HIF1A 3.03961860136032 1.11672209617395e-24 -0.0887083952652183 0.694448347585856 MirTarget -0.194707893705988 1.28811205175096e-08 NA NA NA hsa-let-7e-5p HMGA2 0.860104282510173 6.04758298373779e-05 3.20669547753427 0.000374823650222635 miRNAWalker2_validate;miRTarBase;MirTarget -0.732830631394279 0.000332285018696133 NA NA NA hsa-let-7f-5p HMGA2 0.495648727272215 0.00355972741198794 3.20669547753427 0.000374823650222635 miRNAWalker2_validate;MirTarget -1.10241489007747 2.22093006633086e-05 NA NA NA hsa-let-7g-5p HMGA2 1.20061455355116 1.50237505511483e-12 3.20669547753427 0.000374823650222635 miRNAWalker2_validate;miRTarBase;MirTarget -1.43231422943387 1.29959880262988e-08 21472347;18308936 Furthermore K-Ras and HMGA2 are well known as targets of let-7g; In this study we evaluated the potential role of precursor pre-let-7g in lung cancer cell metastasis focusing on the two targets of let-7g HMGA2 and K-Ras;In let-7g expressing tumors reductions in Ras family and HMGA2 protein levels were detected; Ectopic expression of K-RasG12D largely rescued let-7g mediated tumor suppression whereas ectopic expression of HMGA2 was less effective metastasis; lung cancer;lung cancer hsa-miR-106b-5p HMGA2 2.46782146831112 1.36171495805632e-23 3.20669547753427 0.000374823650222635 miRNATAP -0.371955259846065 0.0281497529699039 NA NA NA hsa-miR-141-5p HMGA2 3.81419396518882 3.21977359736126e-18 3.20669547753427 0.000374823650222635 mirMAP -0.386721730062858 5.04546077064663e-05 NA NA NA hsa-miR-195-3p HMGA2 -0.658653229922836 0.0142127125129199 3.20669547753427 0.000374823650222635 mirMAP -0.350116270182091 0.035971646350522 NA NA NA hsa-miR-20b-5p HMGA2 2.07706563022469 1.10107236083433e-05 3.20669547753427 0.000374823650222635 miRNATAP -0.302366166322021 0.000973404425265467 NA NA NA hsa-miR-23b-3p HMGA2 -0.251132426825047 0.150200321210792 3.20669547753427 0.000374823650222635 mirMAP -0.866480952730137 0.000675818768235312 NA NA NA hsa-miR-29b-2-5p HMGA2 0.910668640983475 0.00666655585493488 3.20669547753427 0.000374823650222635 mirMAP -1.28292888520437 2.32883058282611e-25 NA NA NA hsa-miR-30b-5p HMGA2 0.800822374912712 0.000133601914525413 3.20669547753427 0.000374823650222635 mirMAP -0.727949169792506 0.00050423325666359 NA NA NA hsa-miR-30c-5p HMGA2 0.778774633108 0.000285599212429136 3.20669547753427 0.000374823650222635 mirMAP -1.06860209233637 1.32355981439901e-07 NA NA NA hsa-miR-30d-3p HMGA2 0.977747550180601 4.3048212205381e-05 3.20669547753427 0.000374823650222635 MirTarget -0.82018709894483 6.65963368294546e-06 NA NA NA hsa-miR-30d-5p HMGA2 0.675423997639582 0.00270618816039773 3.20669547753427 0.000374823650222635 mirMAP -1.48013543504836 5.93879658627237e-15 NA NA NA hsa-miR-30e-3p HMGA2 -0.215663037684509 0.235375122783546 3.20669547753427 0.000374823650222635 MirTarget -1.74148468984049 2.91502040569628e-13 NA NA NA hsa-miR-30e-5p HMGA2 1.23904909539663 1.35561917122157e-09 3.20669547753427 0.000374823650222635 mirMAP -1.45238572738576 2.51760507887125e-12 NA NA NA hsa-miR-320a HMGA2 0.438165828017084 0.0390159073347133 3.20669547753427 0.000374823650222635 mirMAP -0.59904315494574 0.00403891079569854 NA NA NA hsa-miR-326 HMGA2 0.715313016136042 0.0610265683213359 3.20669547753427 0.000374823650222635 miRNATAP -0.229170838040218 0.047601931563562 NA NA NA hsa-miR-330-3p HMGA2 0.876747334239085 0.00073709016089703 3.20669547753427 0.000374823650222635 mirMAP -0.728029469344746 1.4280925148101e-05 NA NA NA hsa-miR-34a-5p HMGA2 1.9016323452565 1.43092834643601e-14 3.20669547753427 0.000374823650222635 miRNAWalker2_validate -0.570917515229347 0.000926842607230156 18803879 miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making poor survival;differentiation gastric cancer hsa-miR-361-5p HMGA2 0.971859117235239 5.30236555707088e-09 3.20669547753427 0.000374823650222635 PITA;miRanda -0.596503583657962 0.0236624437529962 NA NA NA hsa-miR-497-5p HMGA2 0.0257087130056286 0.918145413833358 3.20669547753427 0.000374823650222635 MirTarget -0.499552665018573 0.00467938635674173 NA NA NA hsa-miR-508-3p HMGA2 1.05493034310846 0.0393857095042515 3.20669547753427 0.000374823650222635 PITA;miRNATAP -0.245514965186331 0.00496568976326385 NA NA NA hsa-miR-532-5p HMGA2 1.55697650978597 1.57884735535196e-11 3.20669547753427 0.000374823650222635 mirMAP -0.410653335437519 0.0279884123983018 NA NA NA hsa-miR-664a-3p HMGA2 0.634721925861133 0.00520070178640421 3.20669547753427 0.000374823650222635 mirMAP -1.44373608964992 1.77731563841952e-14 NA NA NA hsa-miR-664a-5p HMGA2 0.505019913598436 0.032933350691651 3.20669547753427 0.000374823650222635 MirTarget -1.30634405967042 7.76894197459835e-13 NA NA NA hsa-miR-93-3p HMGA2 2.85383869771942 5.64481766902125e-23 3.20669547753427 0.000374823650222635 mirMAP -0.283827579027649 0.0493695679424236 NA NA NA hsa-miR-93-5p HMGA2 3.03961860136032 1.11672209617395e-24 3.20669547753427 0.000374823650222635 miRNATAP -0.336142311841825 0.0164038445316638 NA NA NA hsa-miR-98-5p HMGA2 1.11154309866014 1.24143909012085e-08 3.20669547753427 0.000374823650222635 miRNAWalker2_validate;miRTarBase;MirTarget -1.24726972778969 1.48507668416586e-08 17222355;23700794 Here we report that HMGA2 expression in head and neck squamous cell carcinoma HNSCC cells is regulated in part by miRNA-98 miR-98;MicroRNA 98 sensitizes cisplatin resistant human lung adenocarcinoma cells by up regulation of HMGA2; MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells; We found that elevated expression of miR-98 led to a higher sensitivity of A549/DDP cells to cisplatin and the protein level of HMGA2 was clearly up-regulated in both A549/DDP and A549 cells by miR-98; We for the first time demonstrated that the expression of miR-98 increases cells spontaneous apoptosis and sensitizes cells to cisplatin at least in part via HMGA2 up-regulation ; head and neck cancer;lung cancer hsa-miR-26b-5p LEF1 0.885393662798425 3.2116297961629e-06 0.331269268157301 0.289787632933989 miRNATAP -0.274638576592703 0.000542709321878361 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression colon cancer hsa-miR-320a LEF1 0.438165828017084 0.0390159073347133 0.331269268157301 0.289787632933989 miRanda;mirMAP -0.14857681648965 0.0389269839680858 NA NA NA hsa-miR-320b LEF1 1.55692969039548 1.41071034251915e-08 0.331269268157301 0.289787632933989 miRanda;mirMAP -0.1663193228511 0.00218419474879364 NA NA NA hsa-miR-33a-3p LEF1 1.72765312072219 1.51784443453521e-07 0.331269268157301 0.289787632933989 miRNATAP -0.161646083992726 0.00116798280053409 NA NA NA hsa-miR-1226-3p LIMS1 1.38118928579963 0.000205503474787488 -0.388381349388172 0.148139138497081 miRNAWalker2_validate -0.112870049936271 0.00443894432422433 NA NA NA hsa-miR-148b-5p LIMS1 2.18024067300781 2.84770452413262e-14 -0.388381349388172 0.148139138497081 MirTarget -0.209076171145331 5.92666851858633e-06 NA NA NA hsa-miR-182-5p LIMS1 3.53923166221814 5.07781258121574e-21 -0.388381349388172 0.148139138497081 MirTarget;miRNATAP -0.116923567741085 0.000354221880553294 NA NA NA hsa-miR-186-5p LIMS1 1.47445398888668 3.0781726595413e-15 -0.388381349388172 0.148139138497081 mirMAP -0.310036272441736 4.16244978896495e-06 NA NA NA hsa-miR-192-5p LIMS1 2.69002528723195 1.22990188194432e-16 -0.388381349388172 0.148139138497081 miRNAWalker2_validate;MirTarget -0.110962262001487 0.00394127356028047 NA NA NA hsa-miR-29b-3p LIMS1 1.65828197923813 1.02676780888141e-09 -0.388381349388172 0.148139138497081 MirTarget;miRNATAP -0.236480586384024 3.67289747531903e-07 NA NA NA hsa-miR-29c-3p LIMS1 -0.00968972577705429 0.97099586346872 -0.388381349388172 0.148139138497081 MirTarget;miRNATAP -0.205163336874868 2.51753331864112e-05 NA NA NA hsa-miR-30b-5p LIMS1 0.800822374912712 0.000133601914525413 -0.388381349388172 0.148139138497081 MirTarget -0.30632928037458 6.1337197028823e-07 NA NA NA hsa-miR-30c-5p LIMS1 0.778774633108 0.000285599212429136 -0.388381349388172 0.148139138497081 MirTarget -0.384678814052223 9.49865089811851e-11 NA NA NA hsa-miR-30d-3p LIMS1 0.977747550180601 4.3048212205381e-05 -0.388381349388172 0.148139138497081 mirMAP -0.187840523219565 0.000518072218915655 NA NA NA hsa-miR-30d-5p LIMS1 0.675423997639582 0.00270618816039773 -0.388381349388172 0.148139138497081 MirTarget -0.204598537740273 0.00039033700976664 NA NA NA hsa-miR-30e-5p LIMS1 1.23904909539663 1.35561917122157e-09 -0.388381349388172 0.148139138497081 MirTarget -0.339276713116783 4.51019594509668e-08 NA NA NA hsa-miR-32-3p LIMS1 2.02436999565685 5.94091197945307e-09 -0.388381349388172 0.148139138497081 mirMAP -0.111691588874867 0.00763095315449379 NA NA NA hsa-miR-374a-3p LIMS1 0.533309330504947 0.00192918429705142 -0.388381349388172 0.148139138497081 mirMAP -0.159039062439653 0.0376980046123985 NA NA NA hsa-miR-429 LIMS1 4.48815175680773 2.44117492218206e-17 -0.388381349388172 0.148139138497081 miRanda;miRNATAP -0.117618757940531 4.18299972573954e-07 NA NA NA hsa-miR-505-3p LIMS1 1.45322244209148 8.86597629645867e-10 -0.388381349388172 0.148139138497081 miRNAWalker2_validate;MirTarget -0.108559554906473 0.0447183749413443 NA NA NA hsa-miR-576-5p LIMS1 2.20467023993664 3.4053475193793e-19 -0.388381349388172 0.148139138497081 mirMAP -0.206553317110472 4.15525272925661e-05 NA NA NA hsa-miR-590-3p LIMS1 2.59289455139753 1.03200520972022e-21 -0.388381349388172 0.148139138497081 miRNAWalker2_validate;miRanda -0.128623419553762 0.00615717388551463 NA NA NA hsa-miR-96-5p LIMS1 4.89433085814374 1.92000659886961e-31 -0.388381349388172 0.148139138497081 TargetScan;miRNATAP -0.130763226603743 7.5931476060149e-06 NA NA NA hsa-miR-192-5p LOXL2 2.69002528723195 1.22990188194432e-16 0.752274659894764 0.0169514910560244 miRNAWalker2_validate -0.180348106199117 6.27015330629637e-05 NA NA NA hsa-miR-28-5p LOXL2 0.230152919654905 0.0742909586754846 0.752274659894764 0.0169514910560244 miRanda -0.455973906650758 0.000181459548210797 NA NA NA hsa-miR-361-5p LOXL2 0.971859117235239 5.30236555707088e-09 0.752274659894764 0.0169514910560244 miRanda -0.53628682071833 2.61457157430625e-09 NA NA NA hsa-let-7a-5p LOXL3 0.618599506841644 2.76973453058748e-05 -0.968455677583596 0.000809448004647299 miRNATAP -0.677142851623546 6.3482597980584e-13 NA NA NA hsa-let-7b-5p LOXL3 0.604314269683977 0.00140009936153214 -0.968455677583596 0.000809448004647299 miRNATAP -0.357945759871693 1.40449840241339e-06 NA NA NA hsa-let-7d-5p LOXL3 1.33236798905207 1.1741085658466e-13 -0.968455677583596 0.000809448004647299 miRNATAP -0.296174723599798 0.000110641100889766 NA NA NA hsa-let-7e-5p LOXL3 0.860104282510173 6.04758298373779e-05 -0.968455677583596 0.000809448004647299 miRNATAP -0.355025136807635 4.11980245334075e-08 NA NA NA hsa-let-7f-5p LOXL3 0.495648727272215 0.00355972741198794 -0.968455677583596 0.000809448004647299 miRNATAP -0.479446558602111 6.04991150307244e-09 NA NA NA hsa-let-7g-5p LOXL3 1.20061455355116 1.50237505511483e-12 -0.968455677583596 0.000809448004647299 miRNATAP -0.587743182295897 1.55169135865329e-13 NA NA NA hsa-miR-125a-5p LOXL3 0.599529391575274 0.0102300147180307 -0.968455677583596 0.000809448004647299 PITA;miRanda -0.24189516780015 5.781791505839e-05 NA NA NA hsa-miR-2110 LOXL3 1.16625590651194 6.4784195289885e-05 -0.968455677583596 0.000809448004647299 miRNATAP -0.363426012396243 4.26225317316907e-13 NA NA NA hsa-miR-320a LOXL3 0.438165828017084 0.0390159073347133 -0.968455677583596 0.000809448004647299 miRanda -0.376931169233166 9.87048192306687e-09 NA NA NA hsa-miR-320b LOXL3 1.55692969039548 1.41071034251915e-08 -0.968455677583596 0.000809448004647299 miRanda -0.242913332761397 1.19866473924613e-06 NA NA NA hsa-miR-34a-5p LOXL3 1.9016323452565 1.43092834643601e-14 -0.968455677583596 0.000809448004647299 MirTarget;miRNATAP -0.400597917013039 9.32832039663351e-14 NA NA NA hsa-miR-942-5p LOXL3 2.35195531153712 5.45059325728841e-16 -0.968455677583596 0.000809448004647299 MirTarget -0.178341718390901 0.000129387753117133 NA NA NA hsa-miR-101-3p NOG 0.522819989585461 0.00375627731618038 -1.04996957338848 0.0827224388167783 miRNATAP -0.349607670488129 0.0334871174365726 NA NA NA hsa-miR-148b-3p NOG 1.97815018171325 6.07715327281595e-26 -1.04996957338848 0.0827224388167783 MirTarget -0.708032615499654 1.42843964112713e-06 NA NA NA hsa-miR-186-5p NOG 1.47445398888668 3.0781726595413e-15 -1.04996957338848 0.0827224388167783 MirTarget;miRNATAP -0.574515041812962 0.000167076298016788 NA NA NA hsa-miR-200b-3p NOG 3.78235093249346 3.18343003239465e-14 -1.04996957338848 0.0827224388167783 MirTarget;TargetScan -0.308168227388684 3.9233328304032e-08 NA NA NA hsa-miR-200c-3p NOG 3.50132673580082 2.42716349086937e-15 -1.04996957338848 0.0827224388167783 MirTarget;miRNATAP -0.376049889176797 2.18212060301929e-09 NA NA NA hsa-miR-26b-3p NOG 2.18464160365372 2.11543189388328e-18 -1.04996957338848 0.0827224388167783 MirTarget -0.371766556975879 0.000976875158835306 NA NA NA hsa-miR-3607-3p NOG 2.68532138541128 5.66716351955047e-14 -1.04996957338848 0.0827224388167783 MirTarget;miRNATAP -0.237259666257936 0.00365848495964816 NA NA NA hsa-miR-429 NOG 4.48815175680773 2.44117492218206e-17 -1.04996957338848 0.0827224388167783 MirTarget;PITA;miRanda;miRNATAP -0.255898504627446 1.09673461633081e-06 NA NA NA hsa-miR-582-3p NOG 0.00876844181512659 0.977126166214707 -1.04996957338848 0.0827224388167783 PITA;miRNATAP -0.486313947844228 3.15417877831524e-07 NA NA NA hsa-miR-101-3p NOTCH1 0.522819989585461 0.00375627731618038 -0.525528621196055 0.0318148804849282 MirTarget -0.144777408795411 0.0294490692942618 NA NA NA hsa-miR-18a-3p NOTCH1 2.14813400940323 2.23460809936028e-06 -0.525528621196055 0.0318148804849282 MirTarget -0.107047863569522 0.00100601356781471 NA NA NA hsa-miR-28-5p NOTCH1 0.230152919654905 0.0742909586754846 -0.525528621196055 0.0318148804849282 miRanda -0.369077331402684 9.33153738807782e-05 NA NA NA hsa-miR-30b-5p NOTCH1 0.800822374912712 0.000133601914525413 -0.525528621196055 0.0318148804849282 miRNATAP -0.117140312197032 0.0389913891192242 NA NA NA hsa-miR-32-5p NOTCH1 2.34056473219422 6.24134585974322e-20 -0.525528621196055 0.0318148804849282 miRNATAP -0.156587251260072 0.000397879604577739 NA NA NA hsa-miR-326 NOTCH1 0.715313016136042 0.0610265683213359 -0.525528621196055 0.0318148804849282 miRNAWalker2_validate;miRTarBase -0.137378974908137 8.96324701817683e-06 NA NA NA hsa-miR-92b-3p NOTCH1 1.20409245530001 3.41055816361655e-06 -0.525528621196055 0.0318148804849282 miRNATAP -0.134581909960881 0.00301080085178634 NA NA NA hsa-let-7a-3p RBPJ 1.42015538786275 7.03375209382654e-13 -0.477632785817332 0.00138046897143435 MirTarget -0.127309740086128 0.000376213110569551 NA NA NA hsa-miR-15a-5p RBPJ 2.34669284378787 1.69544424500258e-23 -0.477632785817332 0.00138046897143435 MirTarget -0.103022608393756 0.000417904387886218 NA NA NA hsa-miR-15b-5p RBPJ 1.57112623124278 9.14247846750597e-13 -0.477632785817332 0.00138046897143435 MirTarget -0.105646020528212 0.00101677688923709 NA NA NA hsa-miR-16-5p RBPJ 1.75824877145857 1.68592440033108e-16 -0.477632785817332 0.00138046897143435 MirTarget -0.100348218423993 0.00227408077704841 NA NA NA hsa-miR-21-5p RBPJ 2.73773305747971 1.38864982139576e-43 -0.477632785817332 0.00138046897143435 MirTarget;miRNATAP -0.114349973224149 0.00054498920378864 NA NA NA hsa-miR-92a-3p RBPJ 2.06460102658973 1.44784291084757e-19 -0.477632785817332 0.00138046897143435 miRNATAP -0.105250740535353 0.000535337407907056 NA NA NA hsa-let-7a-3p SNAI1 1.42015538786275 7.03375209382654e-13 -1.12780952187838 0.00095233459487771 miRNATAP -0.165035217982428 0.0455822172080522 NA NA NA hsa-miR-26b-5p SNAI1 0.885393662798425 3.2116297961629e-06 -1.12780952187838 0.00095233459487771 miRNAWalker2_validate -0.270683501838153 0.00191779575288777 NA NA NA hsa-miR-30b-5p SNAI1 0.800822374912712 0.000133601914525413 -1.12780952187838 0.00095233459487771 miRTarBase;miRNATAP -0.386788682351388 8.44716320812545e-07 NA NA NA hsa-miR-30c-5p SNAI1 0.778774633108 0.000285599212429136 -1.12780952187838 0.00095233459487771 miRTarBase;miRNATAP -0.417101890652328 4.933141879555e-08 NA NA NA hsa-miR-30d-5p SNAI1 0.675423997639582 0.00270618816039773 -1.12780952187838 0.00095233459487771 miRTarBase;miRNATAP -0.629945763211041 6.71587006206153e-19 26501435 miR 30d Blocked Transforming Growth Factor β1 Induced Epithelial Mesenchymal Transition by Targeting Snail in Ovarian Cancer Cells; Luciferase activity assay was performed to verify the direct inhibition of Snail by miR-30d; Furthermore Snail was identified as the direct target of miR-30d; Our results revealed that miR-30d functioned as a suppressor of ovarian cancer progression by decreasing Snail expression and thus blocking TGF-β1-induced EMT process suggesting the potentiality of miR-30d analogs to be used as therapeutics for ovarian cancer progression ovarian cancer hsa-miR-30e-5p SNAI1 1.23904909539663 1.35561917122157e-09 -1.12780952187838 0.00095233459487771 miRTarBase -0.647252090970601 6.51585963855331e-17 NA NA NA hsa-miR-335-5p SNAI1 1.77247705492746 2.22457658872091e-06 -1.12780952187838 0.00095233459487771 miRNAWalker2_validate -0.111561584810692 0.0108854006923972 NA NA NA hsa-miR-590-5p SNAI1 3.18300989862077 2.06813568597893e-26 -1.12780952187838 0.00095233459487771 miRanda -0.15154249631799 0.00465970370203214 NA NA NA hsa-miR-107 SNAI2 1.30977326593435 1.30372468603965e-11 -0.280307189347724 0.489884936104145 miRanda -0.587951478655937 2.23241515205897e-09 NA NA NA hsa-miR-126-5p SNAI2 0.895338176458417 2.33372756450713e-05 -0.280307189347724 0.489884936104145 MirTarget -0.200095252463554 0.0311551209498949 NA NA NA hsa-miR-148b-3p SNAI2 1.97815018171325 6.07715327281595e-26 -0.280307189347724 0.489884936104145 miRNAWalker2_validate -0.5115588617257 1.85198661011602e-07 NA NA NA hsa-miR-182-5p SNAI2 3.53923166221814 5.07781258121574e-21 -0.280307189347724 0.489884936104145 miRNAWalker2_validate;miRNATAP -0.226684880391696 4.11330558077327e-06 NA NA NA hsa-miR-200b-3p SNAI2 3.78235093249346 3.18343003239465e-14 -0.280307189347724 0.489884936104145 TargetScan -0.267184160966678 5.83468454644939e-13 NA NA NA hsa-miR-200c-3p SNAI2 3.50132673580082 2.42716349086937e-15 -0.280307189347724 0.489884936104145 miRNATAP -0.183480437180395 1.58844201912264e-05 NA NA NA hsa-miR-330-3p SNAI2 0.876747334239085 0.00073709016089703 -0.280307189347724 0.489884936104145 PITA -0.244344141932354 0.00118305093009477 NA NA NA hsa-miR-335-3p SNAI2 3.08791651139852 5.31309869723517e-12 -0.280307189347724 0.489884936104145 mirMAP -0.125422480922013 0.00324023238716861 NA NA NA hsa-miR-33a-3p SNAI2 1.72765312072219 1.51784443453521e-07 -0.280307189347724 0.489884936104145 MirTarget -0.326770909713066 3.29484348166007e-07 NA NA NA hsa-miR-375 SNAI2 1.13910305294079 0.0512283522214186 -0.280307189347724 0.489884936104145 miRanda -0.160294717693396 1.3349557949902e-06 NA NA NA hsa-miR-421 SNAI2 1.17791565395543 6.78526676976629e-06 -0.280307189347724 0.489884936104145 miRanda -0.277190656175256 0.000195037380670986 NA NA NA hsa-miR-429 SNAI2 4.48815175680773 2.44117492218206e-17 -0.280307189347724 0.489884936104145 PITA;miRanda;miRNATAP -0.243690996915046 1.98440445952138e-12 NA NA NA hsa-miR-532-5p SNAI2 1.55697650978597 1.57884735535196e-11 -0.280307189347724 0.489884936104145 PITA -0.570320787851888 2.40819282921953e-12 NA NA NA hsa-miR-96-5p SNAI2 4.89433085814374 1.92000659886961e-31 -0.280307189347724 0.489884936104145 miRNATAP -0.21174388168592 1.54578985770895e-06 NA NA NA hsa-miR-1-3p SOX9 -3.48370702447685 1.98579484008516e-13 1.13040984801329 0.0354704160206486 MirTarget -0.105386330393545 0.0482633528242291 NA NA NA hsa-miR-101-3p SOX9 0.522819989585461 0.00375627731618038 1.13040984801329 0.0354704160206486 miRNAWalker2_validate;miRNATAP -0.539844940330791 0.000204431201243516 23178713 Ectopic expression of miR-101 significantly inhibited HCC cell proliferation and tumorigenicity by targeting SOX9; Therefore miR-101 may suppress HCC tumor progression by down-regulating SOX9 progression liver cancer hsa-miR-30b-5p SOX9 0.800822374912712 0.000133601914525413 1.13040984801329 0.0354704160206486 MirTarget -0.318002910195815 0.010685542852497 NA NA NA hsa-miR-30c-5p SOX9 0.778774633108 0.000285599212429136 1.13040984801329 0.0354704160206486 MirTarget;miRNATAP -0.365035942002407 0.00266402091223478 NA NA NA hsa-miR-30d-5p SOX9 0.675423997639582 0.00270618816039773 1.13040984801329 0.0354704160206486 MirTarget;miRNATAP -0.434664007643438 0.000170467688323101 NA NA NA hsa-miR-30e-5p SOX9 1.23904909539663 1.35561917122157e-09 1.13040984801329 0.0354704160206486 MirTarget -0.485497322443767 0.000110039719791244 NA NA NA hsa-miR-320a SOX9 0.438165828017084 0.0390159073347133 1.13040984801329 0.0354704160206486 miRanda;miRNATAP -0.277550082459125 0.0250284600790132 NA NA NA hsa-miR-33a-3p SOX9 1.72765312072219 1.51784443453521e-07 1.13040984801329 0.0354704160206486 mirMAP -0.175796869781922 0.0410958416143202 NA NA NA hsa-miR-582-3p SOX9 0.00876844181512659 0.977126166214707 1.13040984801329 0.0354704160206486 PITA;miRNATAP -0.384458473099014 5.81907031889053e-06 NA NA NA hsa-miR-582-5p SOX9 0.609226359812689 0.032988717891497 1.13040984801329 0.0354704160206486 PITA;miRNATAP -0.335428447645588 0.000227574582108014 NA NA NA hsa-miR-744-5p TGFB1 1.48254348878737 3.23019501613577e-09 -0.000200257511168367 0.999409206375481 miRNAWalker2_validate;miRNATAP -0.229419410482444 6.9384219754003e-06 NA NA NA hsa-miR-107 TGFB2 1.30977326593435 1.30372468603965e-11 -1.19931727990522 0.00330886829654418 miRanda -0.51939474457829 1.98547903259176e-07 NA NA NA hsa-miR-126-5p TGFB2 0.895338176458417 2.33372756450713e-05 -1.19931727990522 0.00330886829654418 mirMAP -0.25743093726133 0.00599073764101041 NA NA NA hsa-miR-130b-3p TGFB2 3.5350292994509 1.73934183852569e-27 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.344962470893237 7.65363506175553e-10 NA NA NA hsa-miR-141-3p TGFB2 5.02396127982626 2.19224509139725e-24 -1.19931727990522 0.00330886829654418 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.360699351018386 8.70106540908034e-24 NA NA NA hsa-miR-148a-3p TGFB2 1.26728238710376 2.52325607402829e-06 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.286009485859132 8.40361643900754e-05 NA NA NA hsa-miR-148b-3p TGFB2 1.97815018171325 6.07715327281595e-26 -1.19931727990522 0.00330886829654418 MirTarget -0.76533615341931 3.3613707731401e-15 NA NA NA hsa-miR-149-5p TGFB2 2.94200492826326 4.93436498919036e-14 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.268302009449797 3.19540597089803e-08 NA NA NA hsa-miR-186-5p TGFB2 1.47445398888668 3.0781726595413e-15 -1.19931727990522 0.00330886829654418 mirMAP -0.621355169758057 1.07645506474653e-09 NA NA NA hsa-miR-200a-3p TGFB2 4.59434485520731 6.38952518573476e-18 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.349625252947739 2.44117272738656e-25 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 3.12352008343999 9.49391438647189e-07 -1.19931727990522 0.00330886829654418 MirTarget -0.137892151335788 5.76268091391752e-06 NA NA NA hsa-miR-29b-3p TGFB2 1.65828197923813 1.02676780888141e-09 -1.19931727990522 0.00330886829654418 miRTarBase;MirTarget;miRNATAP -0.231729413265765 0.0012231669483933 NA NA NA hsa-miR-29c-3p TGFB2 -0.00968972577705429 0.97099586346872 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.531424404132598 2.96641887384219e-13 NA NA NA hsa-miR-301a-3p TGFB2 2.81024345929638 2.29784847962242e-17 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.322704555190408 7.77034372961379e-08 NA NA NA hsa-miR-32-3p TGFB2 2.02436999565685 5.94091197945307e-09 -1.19931727990522 0.00330886829654418 mirMAP -0.27315114570865 1.69846948907938e-05 NA NA NA hsa-miR-320a TGFB2 0.438165828017084 0.0390159073347133 -1.19931727990522 0.00330886829654418 miRanda -0.39585907442477 2.33018021074793e-05 NA NA NA hsa-miR-320b TGFB2 1.55692969039548 1.41071034251915e-08 -1.19931727990522 0.00330886829654418 miRanda -0.298228917269413 2.53643349382992e-05 NA NA NA hsa-miR-324-5p TGFB2 2.95683728155095 1.32960514360912e-20 -1.19931727990522 0.00330886829654418 miRanda -0.302705023736643 2.71602770897574e-07 NA NA NA hsa-miR-330-3p TGFB2 0.876747334239085 0.00073709016089703 -1.19931727990522 0.00330886829654418 miRNATAP -0.457254743325048 1.06037579343258e-09 NA NA NA hsa-miR-330-5p TGFB2 1.15100069700871 4.85551805046014e-07 -1.19931727990522 0.00330886829654418 miRanda -0.360450971736555 2.54978879561545e-05 NA NA NA hsa-miR-331-5p TGFB2 2.17414714166315 1.54547681391888e-18 -1.19931727990522 0.00330886829654418 miRNATAP -0.239937976385475 0.00244538329219784 NA NA NA hsa-miR-335-3p TGFB2 3.08791651139852 5.31309869723517e-12 -1.19931727990522 0.00330886829654418 mirMAP -0.22185528629857 1.89547879442152e-07 NA NA NA hsa-miR-335-5p TGFB2 1.77247705492746 2.22457658872091e-06 -1.19931727990522 0.00330886829654418 miRNAWalker2_validate -0.252111592909568 1.14412319370904e-06 NA NA NA hsa-miR-33a-3p TGFB2 1.72765312072219 1.51784443453521e-07 -1.19931727990522 0.00330886829654418 MirTarget;mirMAP -0.371056624502634 8.36332661191753e-09 NA NA NA hsa-miR-361-5p TGFB2 0.971859117235239 5.30236555707088e-09 -1.19931727990522 0.00330886829654418 miRNATAP -0.810004741713957 2.97484706931026e-12 NA NA NA hsa-miR-362-3p TGFB2 2.0756816987665 3.89026064579331e-12 -1.19931727990522 0.00330886829654418 miRanda -0.218398256631292 0.00107142313440827 NA NA NA hsa-miR-362-5p TGFB2 1.59303749908759 9.582675908797e-08 -1.19931727990522 0.00330886829654418 MirTarget -0.222085312260446 0.000683040393757458 NA NA NA hsa-miR-374a-5p TGFB2 0.484615721953736 0.0042981729815149 -1.19931727990522 0.00330886829654418 mirMAP -0.292264596541037 0.0136347038708632 NA NA NA hsa-miR-429 TGFB2 4.48815175680773 2.44117492218206e-17 -1.19931727990522 0.00330886829654418 miRNATAP -0.354478665199625 1.01610694076904e-25 NA NA NA hsa-miR-454-3p TGFB2 2.47234127820054 1.12878018736016e-21 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.36249217687122 1.13442108861214e-06 NA NA NA hsa-miR-500a-5p TGFB2 1.72110365584658 3.0807246212659e-10 -1.19931727990522 0.00330886829654418 mirMAP -0.230492171637341 0.0012015489418391 NA NA NA hsa-miR-500b-5p TGFB2 1.72172606292185 3.06592098153205e-10 -1.19931727990522 0.00330886829654418 MirTarget -0.231076703558946 0.00116359223151538 NA NA NA hsa-miR-589-3p TGFB2 2.51971841868825 2.39125940264107e-11 -1.19931727990522 0.00330886829654418 MirTarget -0.125134916260589 0.0325888808995323 NA NA NA hsa-miR-590-3p TGFB2 2.59289455139753 1.03200520972022e-21 -1.19931727990522 0.00330886829654418 mirMAP -0.266142801996328 0.000194961333085026 NA NA NA hsa-miR-590-5p TGFB2 3.18300989862077 2.06813568597893e-26 -1.19931727990522 0.00330886829654418 miRanda;miRNATAP -0.324271064441974 3.01832441227307e-07 NA NA NA hsa-miR-944 TGFB2 2.91186649218281 1.31574753528144e-06 -1.19931727990522 0.00330886829654418 mirMAP -0.180206577855112 5.25792273122866e-08 NA NA NA hsa-let-7a-5p TGFBR1 0.618599506841644 2.76973453058748e-05 -0.531745632851025 0.0111481565689226 TargetScan;miRNATAP -0.244428925468535 0.000440383623292106 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC colorectal cancer hsa-let-7b-5p TGFBR1 0.604314269683977 0.00140009936153214 -0.531745632851025 0.0111481565689226 miRNATAP -0.164395211205111 0.002334077702266 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC; In luciferase assays the risk-associated allele for rs868 was associated with half the luciferase expression in the presence of miRNA let-7b-5p compared with protective allele suggesting more binding of let-7b-5p and less TGFBR1 expression colorectal cancer hsa-let-7d-5p TGFBR1 1.33236798905207 1.1741085658466e-13 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRNATAP -0.249677273322744 5.91436156062502e-06 NA NA NA hsa-let-7e-5p TGFBR1 0.860104282510173 6.04758298373779e-05 -0.531745632851025 0.0111481565689226 miRNATAP -0.165779353656999 0.000445651685953496 NA NA NA hsa-let-7f-5p TGFBR1 0.495648727272215 0.00355972741198794 -0.531745632851025 0.0111481565689226 miRNATAP -0.212539435969951 0.000421071580866339 NA NA NA hsa-let-7g-5p TGFBR1 1.20061455355116 1.50237505511483e-12 -0.531745632851025 0.0111481565689226 miRNATAP -0.498242721643013 1.58222259474873e-18 NA NA NA hsa-miR-101-3p TGFBR1 0.522819989585461 0.00375627731618038 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRNATAP -0.356084641759078 1.678272043475e-10 NA NA NA hsa-miR-126-5p TGFBR1 0.895338176458417 2.33372756450713e-05 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.153123735128566 0.00137633400200009 NA NA NA hsa-miR-128-3p TGFBR1 1.63756041666078 6.79626586407187e-14 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRTarBase -0.248098643403413 2.90608464652714e-08 NA NA NA hsa-miR-130b-3p TGFBR1 3.5350292994509 1.73934183852569e-27 -0.531745632851025 0.0111481565689226 miRNATAP -0.134668437053487 3.34039315804437e-06 NA NA NA hsa-miR-16-2-3p TGFBR1 2.31623086727196 4.29838149388188e-20 -0.531745632851025 0.0111481565689226 mirMAP -0.118014665876922 0.00216991899384218 NA NA NA hsa-miR-181c-5p TGFBR1 1.58587920618301 1.57506918816933e-10 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.16918051477343 2.32913877572708e-05 NA NA NA hsa-miR-186-5p TGFBR1 1.47445398888668 3.0781726595413e-15 -0.531745632851025 0.0111481565689226 mirMAP -0.261901522962087 6.15270096138054e-07 NA NA NA hsa-miR-200b-3p TGFBR1 3.78235093249346 3.18343003239465e-14 -0.531745632851025 0.0111481565689226 mirMAP -0.185163040320424 3.55754064059769e-23 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-2110 TGFBR1 1.16625590651194 6.4784195289885e-05 -0.531745632851025 0.0111481565689226 miRNATAP -0.203122265430452 3.02839928126399e-08 NA NA NA hsa-miR-301a-3p TGFBR1 2.81024345929638 2.29784847962242e-17 -0.531745632851025 0.0111481565689226 miRNATAP -0.188558650494062 6.94428278524489e-10 NA NA NA hsa-miR-32-3p TGFBR1 2.02436999565685 5.94091197945307e-09 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.116207615183923 0.000365699800115398 NA NA NA hsa-miR-3200-3p TGFBR1 2.70510522077868 1.90469509928484e-08 -0.531745632851025 0.0111481565689226 miRNATAP -0.120700105473579 2.69621919466987e-08 NA NA NA hsa-miR-320a TGFBR1 0.438165828017084 0.0390159073347133 -0.531745632851025 0.0111481565689226 PITA;miRanda;miRNATAP -0.326176915517583 4.1064210958607e-12 NA NA NA hsa-miR-320b TGFBR1 1.55692969039548 1.41071034251915e-08 -0.531745632851025 0.0111481565689226 PITA;miRanda;miRNATAP -0.191128801910238 1.11537638054288e-07 NA NA NA hsa-miR-330-3p TGFBR1 0.876747334239085 0.00073709016089703 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.231238826647919 1.69019842696319e-09 NA NA NA hsa-miR-331-3p TGFBR1 2.28379581858927 1.99663919173155e-18 -0.531745632851025 0.0111481565689226 PITA;miRNATAP -0.227588969955072 5.92157067223612e-10 NA NA NA hsa-miR-361-5p TGFBR1 0.971859117235239 5.30236555707088e-09 -0.531745632851025 0.0111481565689226 miRanda;mirMAP;miRNATAP -0.327512599032841 4.9385335452745e-08 NA NA NA hsa-miR-374a-5p TGFBR1 0.484615721953736 0.0042981729815149 -0.531745632851025 0.0111481565689226 mirMAP -0.1725550403971 0.00437986725180039 NA NA NA hsa-miR-429 TGFBR1 4.48815175680773 2.44117492218206e-17 -0.531745632851025 0.0111481565689226 miRanda;miRNATAP -0.169764852224625 2.30995613689702e-22 NA NA NA hsa-miR-454-3p TGFBR1 2.47234127820054 1.12878018736016e-21 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.205677505304361 6.16209314820036e-08 NA NA NA hsa-miR-500a-5p TGFBR1 1.72110365584658 3.0807246212659e-10 -0.531745632851025 0.0111481565689226 mirMAP -0.111391945877042 0.0022402772038843 NA NA NA hsa-miR-576-5p TGFBR1 2.20467023993664 3.4053475193793e-19 -0.531745632851025 0.0111481565689226 mirMAP -0.201284779052 2.74992936654638e-07 NA NA NA hsa-miR-589-3p TGFBR1 2.51971841868825 2.39125940264107e-11 -0.531745632851025 0.0111481565689226 mirMAP -0.104859492543737 0.000438540974273448 NA NA NA hsa-miR-590-3p TGFBR1 2.59289455139753 1.03200520972022e-21 -0.531745632851025 0.0111481565689226 PITA;miRanda;mirMAP;miRNATAP -0.139228339501584 0.000139021577037225 NA NA NA hsa-miR-590-5p TGFBR1 3.18300989862077 2.06813568597893e-26 -0.531745632851025 0.0111481565689226 PITA;miRanda -0.158386241001983 1.04882834086946e-06 NA NA NA hsa-miR-664a-3p TGFBR1 0.634721925861133 0.00520070178640421 -0.531745632851025 0.0111481565689226 mirMAP -0.321621318973717 1.70943055444078e-13 NA NA NA hsa-miR-769-5p TGFBR1 1.82023760596845 9.6815886564134e-14 -0.531745632851025 0.0111481565689226 PITA;miRNATAP -0.228524293799953 9.85398652877069e-09 NA NA NA hsa-miR-944 TGFBR1 2.91186649218281 1.31574753528144e-06 -0.531745632851025 0.0111481565689226 PITA;mirMAP -0.104949150832685 4.75355134217921e-10 NA NA NA hsa-miR-96-5p TGFBR1 4.89433085814374 1.92000659886961e-31 -0.531745632851025 0.0111481565689226 TargetScan;miRNATAP -0.138876787398621 7.90055950171446e-10 NA NA NA hsa-miR-98-5p TGFBR1 1.11154309866014 1.24143909012085e-08 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate -0.401926180925558 8.43130029155261e-16 NA NA NA hsa-let-7b-5p TGFBR3 0.604314269683977 0.00140009936153214 -2.59061685335061 7.44943414202018e-11 MirTarget -0.353571778463802 0.000737905769843802 NA NA NA hsa-let-7i-5p TGFBR3 0.412877696970403 0.00622731051981756 -2.59061685335061 7.44943414202018e-11 MirTarget -0.694609854826207 1.28284665233358e-07 NA NA NA hsa-miR-15a-5p TGFBR3 2.34669284378787 1.69544424500258e-23 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.334666618812116 2.4364757552723e-05 NA NA NA hsa-miR-15b-5p TGFBR3 1.57112623124278 9.14247846750597e-13 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.358067034321255 4.08959861418962e-05 NA NA NA hsa-miR-16-2-3p TGFBR3 2.31623086727196 4.29838149388188e-20 -2.59061685335061 7.44943414202018e-11 mirMAP -0.544752570527393 6.96637221131045e-14 NA NA NA hsa-miR-16-5p TGFBR3 1.75824877145857 1.68592440033108e-16 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.535995055796637 1.19037291949918e-09 NA NA NA hsa-miR-181a-5p TGFBR3 2.29556023480783 1.8138457900616e-21 -2.59061685335061 7.44943414202018e-11 miRNAWalker2_validate;mirMAP;miRNATAP -0.533327553140963 2.53974355292015e-12 NA NA NA hsa-miR-181b-5p TGFBR3 2.49307679431293 3.92829250217627e-20 -2.59061685335061 7.44943414202018e-11 mirMAP -0.432103104420789 2.3616864237891e-10 NA NA NA hsa-miR-181c-5p TGFBR3 1.58587920618301 1.57506918816933e-10 -2.59061685335061 7.44943414202018e-11 mirMAP;miRNATAP -0.172396736027208 0.0276183859643452 NA NA NA hsa-miR-185-3p TGFBR3 2.3922478518806 1.3373426768452e-14 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.178532534746358 0.0036751676836322 NA NA NA hsa-miR-186-5p TGFBR3 1.47445398888668 3.0781726595413e-15 -2.59061685335061 7.44943414202018e-11 MirTarget -0.432866677091555 2.38094635988513e-05 NA NA NA hsa-miR-18a-3p TGFBR3 2.14813400940323 2.23460809936028e-06 -2.59061685335061 7.44943414202018e-11 MirTarget -0.384745830428724 3.20279500560706e-13 NA NA NA hsa-miR-18a-5p TGFBR3 3.78535678765353 3.72446596213886e-26 -2.59061685335061 7.44943414202018e-11 MirTarget -0.408782150301723 1.32531260268041e-14 NA NA NA hsa-miR-193a-3p TGFBR3 1.60460546928078 2.86169793322984e-07 -2.59061685335061 7.44943414202018e-11 MirTarget;miRanda;miRNATAP -0.404117628316179 3.34660410567723e-11 NA NA NA hsa-miR-193b-3p TGFBR3 2.25711804611899 4.1940744806631e-14 -2.59061685335061 7.44943414202018e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.54263409776695 1.06348017136205e-18 NA NA NA hsa-miR-21-5p TGFBR3 2.73773305747971 1.38864982139576e-43 -2.59061685335061 7.44943414202018e-11 miRNAWalker2_validate -0.873696976080408 1.42070935389156e-24 NA NA NA hsa-miR-222-5p TGFBR3 1.25632771414778 0.000138653440511922 -2.59061685335061 7.44943414202018e-11 MirTarget -0.637586491113155 8.70674708946357e-31 NA NA NA hsa-miR-223-3p TGFBR3 0.390350910791999 0.345956164976892 -2.59061685335061 7.44943414202018e-11 MirTarget -0.357942230234306 8.65290396410165e-15 NA NA NA hsa-miR-23a-3p TGFBR3 1.00493340843378 2.55313889288924e-08 -2.59061685335061 7.44943414202018e-11 MirTarget;mirMAP -0.922565153945025 1.07662734633214e-18 NA NA NA hsa-miR-27a-3p TGFBR3 1.66542180327138 4.93775737894805e-13 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.856547795782396 8.50152722903816e-28 NA NA NA hsa-miR-29a-5p TGFBR3 1.46749674755271 3.34605004270294e-07 -2.59061685335061 7.44943414202018e-11 mirMAP -0.680050674340825 1.4093844780056e-23 NA NA NA hsa-miR-32-3p TGFBR3 2.02436999565685 5.94091197945307e-09 -2.59061685335061 7.44943414202018e-11 mirMAP -0.147442607471617 0.0204519778455496 NA NA NA hsa-miR-338-3p TGFBR3 0.453166438193782 0.144583389707558 -2.59061685335061 7.44943414202018e-11 miRanda -0.32591907256696 2.15757294303162e-07 NA NA NA hsa-miR-339-5p TGFBR3 2.68710938429893 3.03134080808154e-16 -2.59061685335061 7.44943414202018e-11 miRanda -0.261061195001236 5.31993152374657e-06 NA NA NA hsa-miR-340-5p TGFBR3 0.30282999308409 0.157744789519131 -2.59061685335061 7.44943414202018e-11 mirMAP -0.300070644061892 0.00119354677245125 NA NA NA hsa-miR-34c-5p TGFBR3 2.07190852984647 7.35776320806257e-08 -2.59061685335061 7.44943414202018e-11 miRanda;miRNATAP -0.277892023741616 1.74141696542429e-07 NA NA NA hsa-miR-3607-3p TGFBR3 2.68532138541128 5.66716351955047e-14 -2.59061685335061 7.44943414202018e-11 mirMAP -0.209035995525523 0.000133096015392737 NA NA NA hsa-miR-361-3p TGFBR3 1.07367425434318 1.73142774168958e-09 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.605594317686423 2.29492169573009e-08 NA NA NA hsa-miR-409-3p TGFBR3 0.877551657794358 0.00171210686733898 -2.59061685335061 7.44943414202018e-11 mirMAP -0.19586487016773 0.00536284050179962 NA NA NA hsa-miR-424-5p TGFBR3 1.61930224569578 1.89642549274994e-10 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.453498113768427 1.3903796591463e-09 NA NA NA hsa-miR-450b-5p TGFBR3 1.69244418548325 1.68064054148881e-10 -2.59061685335061 7.44943414202018e-11 mirMAP -0.164643823275733 0.024373231426323 NA NA NA hsa-miR-455-5p TGFBR3 2.2582442061694 1.43472128037398e-13 -2.59061685335061 7.44943414202018e-11 miRanda -0.595169359534449 1.29501226263914e-23 NA NA NA hsa-miR-484 TGFBR3 1.81844463411787 1.82951571230938e-15 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.285353013064365 0.000636411287742009 NA NA NA hsa-miR-589-3p TGFBR3 2.51971841868825 2.39125940264107e-11 -2.59061685335061 7.44943414202018e-11 MirTarget -0.350435514214757 8.24412223410027e-10 NA NA NA hsa-miR-590-3p TGFBR3 2.59289455139753 1.03200520972022e-21 -2.59061685335061 7.44943414202018e-11 MirTarget;miRanda;mirMAP -0.471663498128764 1.30242745091055e-11 NA NA NA hsa-miR-590-5p TGFBR3 3.18300989862077 2.06813568597893e-26 -2.59061685335061 7.44943414202018e-11 miRanda -0.399800495757582 1.45902129417123e-10 NA NA NA hsa-miR-625-5p TGFBR3 1.42540152147292 1.95797147911206e-06 -2.59061685335061 7.44943414202018e-11 MirTarget -0.303726876266838 1.96419820901604e-05 NA NA NA hsa-miR-627-5p TGFBR3 1.91115607258341 1.92839519618473e-09 -2.59061685335061 7.44943414202018e-11 MirTarget -0.302068567741635 1.24234557528916e-05 NA NA NA hsa-miR-7-1-3p TGFBR3 1.84950311431067 1.25300363397654e-13 -2.59061685335061 7.44943414202018e-11 mirMAP -0.481191222243271 1.84156222707957e-10 NA NA NA hsa-miR-320a WNT11 0.438165828017084 0.0390159073347133 -0.821017630142777 0.174343340060726 miRanda -0.419932472809252 0.00246805866460523 NA NA NA hsa-miR-330-3p WNT11 0.876747334239085 0.00073709016089703 -0.821017630142777 0.174343340060726 miRNATAP -0.630031523186883 1.32892882444745e-08 NA NA NA hsa-miR-429 WNT11 4.48815175680773 2.44117492218206e-17 -0.821017630142777 0.174343340060726 miRNATAP -0.323236245003944 4.91620754160683e-10 NA NA NA