miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-140-3p ADAM17 -0.123864258867705 0.14796686619449 0.120988369271805 0.0472306940454773 PITA;miRNATAP -0.132570065249377 0.000222048374545019 NA NA NA hsa-miR-338-3p ADAM17 -0.39963704679384 0.0034410643220691 0.120988369271805 0.0472306940454773 PITA;miRanda;miRNATAP -0.122198017386768 2.79501719664482e-11 26617808 MiR 338 3p inhibits the proliferation and migration of gastric cancer cells by targeting ADAM17; Moreover we identified A disintegrin and metalloproteinase 17 ADAM17 gene as potential target of miR-338-3p; Importantly ADAM17 rescued the miR-338-3p mediated inhibition of cell proliferation migration and invasion; Our study suggested that miR-338-3p is significantly decreased in gastric cancer and inhibits cell proliferation migration and invasion partially via the downregulation of ADAM17 gastric cancer hsa-miR-7-1-3p ADAM17 -0.0894475316162393 0.37322359785108 0.120988369271805 0.0472306940454773 mirMAP -0.114304185828554 8.00554206172382e-07 NA NA NA hsa-miR-139-5p APH1A -0.647754756897633 2.15378307237163e-06 0.137178624352459 0.00501942012074048 miRanda -0.120481929253767 1.59359057904804e-47 NA NA NA hsa-miR-769-3p APH1A -0.287263649023213 0.018145224330845 0.137178624352459 0.00501942012074048 PITA -0.10472938820932 1.40866805938613e-28 NA NA NA hsa-let-7e-5p CREBBP 0.0471189209570344 0.657255455444655 -0.047978601693571 0.404366818323115 miRNAWalker2_validate -0.117826371466181 2.40828040481683e-09 NA NA NA hsa-miR-1301-3p CREBBP -0.105695714210758 0.152249184194132 -0.047978601693571 0.404366818323115 miRNAWalker2_validate -0.145041633909724 7.95662975669671e-09 NA NA NA hsa-miR-142-5p CREBBP 0.434884875454107 0.000575570345702788 -0.047978601693571 0.404366818323115 mirMAP -0.106025113337559 1.85000672571322e-14 NA NA NA hsa-miR-186-5p CREBBP 0.0606381894130505 0.514217717592464 -0.047978601693571 0.404366818323115 mirMAP;miRNATAP -0.147890785462563 1.79437968717686e-12 NA NA NA hsa-miR-200b-3p CREBBP 0.245768526504511 0.0580744465744737 -0.047978601693571 0.404366818323115 mirMAP -0.123048999824309 2.44260177280472e-19 NA NA NA hsa-miR-200c-3p CREBBP 0.413752622631695 8.6936333715621e-06 -0.047978601693571 0.404366818323115 mirMAP -0.133825633175237 1.58816104033339e-12 NA NA NA hsa-miR-26a-5p CREBBP 0.033823776747294 0.726610414342369 -0.047978601693571 0.404366818323115 miRNATAP -0.116054995750247 2.26207553528174e-07 NA NA NA hsa-miR-26b-5p CREBBP -0.0984536538762768 0.231803769574623 -0.047978601693571 0.404366818323115 miRNATAP -0.164373734995276 2.00260444141814e-10 NA NA NA hsa-miR-30a-3p CREBBP 0.0655410309550977 0.509541256241954 -0.047978601693571 0.404366818323115 MirTarget;miRNATAP -0.118406533193908 4.53827599405547e-07 NA NA NA hsa-miR-30e-3p CREBBP 0.00173769765874887 0.984965501547409 -0.047978601693571 0.404366818323115 MirTarget -0.140461173361411 1.16147592773995e-07 NA NA NA hsa-miR-361-5p CREBBP 0.0107519600643302 0.882230614095565 -0.047978601693571 0.404366818323115 PITA;miRanda;miRNATAP -0.20977112720493 4.42799460550161e-12 NA NA NA hsa-miR-374a-3p CREBBP 0.176226170437625 0.0343958848425446 -0.047978601693571 0.404366818323115 miRNATAP -0.166006934673094 4.57407449473457e-10 NA NA NA hsa-miR-548b-3p CREBBP 0.340474544210108 0.00224491592019745 -0.047978601693571 0.404366818323115 miRNATAP -0.122339265277455 1.92040117401605e-14 NA NA NA hsa-miR-590-3p CREBBP 0.312951515438396 0.000480455423843996 -0.047978601693571 0.404366818323115 PITA;miRanda;mirMAP;miRNATAP -0.145167352998136 1.52352483162506e-13 NA NA NA hsa-miR-628-3p CREBBP -0.243661425878074 0.0594758496279051 -0.047978601693571 0.404366818323115 PITA -0.103726817505493 6.28819709328743e-14 NA NA NA hsa-let-7f-1-3p CTBP2 0.110713086694053 0.21484524300518 -0.200717956151272 9.39078162124122e-05 mirMAP -0.123635033524006 2.81525053869263e-11 NA NA NA hsa-miR-146b-5p CTBP2 0.441078059667297 0.000237619929889385 -0.200717956151272 9.39078162124122e-05 miRanda -0.172671943665044 2.98027985474638e-36 NA NA NA hsa-miR-200b-3p CTBP2 0.245768526504511 0.0580744465744737 -0.200717956151272 9.39078162124122e-05 TargetScan -0.100189482289038 9.93585528445471e-15 NA NA NA hsa-miR-590-3p CTBP2 0.312951515438396 0.000480455423843996 -0.200717956151272 9.39078162124122e-05 PITA;miRanda -0.123841792236004 2.14669915677024e-11 NA NA NA hsa-let-7b-3p DLL1 -0.00495618733298731 0.952288980686967 -0.293706554700173 0.00827704512535356 miRNATAP -0.174717076894164 0.00273783859948614 NA NA NA hsa-miR-103a-3p DLL1 -0.147443193527362 0.128400914654149 -0.293706554700173 0.00827704512535356 miRNATAP -0.512822934132837 5.70853583345826e-11 NA NA NA hsa-miR-107 DLL1 -0.121070851008387 0.198381281894242 -0.293706554700173 0.00827704512535356 PITA;miRanda;miRNATAP -0.451878411696484 2.86672868683457e-19 NA NA NA hsa-miR-1179 DLL1 -0.117056451908751 0.310989525634765 -0.293706554700173 0.00827704512535356 PITA;miRNATAP -0.232638359983413 9.86168140300361e-09 NA NA NA hsa-miR-140-5p DLL1 0.065063507103468 0.380452509211773 -0.293706554700173 0.00827704512535356 miRanda -0.378583874772251 1.59373367897241e-08 NA NA NA hsa-miR-142-3p DLL1 0.558908907203977 1.37828834702416e-05 -0.293706554700173 0.00827704512535356 miRanda -0.412505644761786 1.68288970703858e-32 NA NA NA hsa-miR-144-5p DLL1 0.0784834905249552 0.620720209395281 -0.293706554700173 0.00827704512535356 miRNATAP -0.184339429987727 2.68303686706927e-10 NA NA NA hsa-miR-146b-5p DLL1 0.441078059667297 0.000237619929889385 -0.293706554700173 0.00827704512535356 miRanda -0.490150824054536 2.86940658303666e-39 NA NA NA hsa-miR-149-5p DLL1 -0.0535821592029952 0.657713892012548 -0.293706554700173 0.00827704512535356 miRNATAP -0.299197071620119 4.03313420485236e-15 NA NA NA hsa-miR-15a-5p DLL1 0.142658985373611 0.0536219185009004 -0.293706554700173 0.00827704512535356 miRNATAP -0.589030343028951 1.40972140442393e-15 NA NA NA hsa-miR-15b-5p DLL1 0.592863156692837 1.41971517354055e-10 -0.293706554700173 0.00827704512535356 miRNATAP -0.428889637568146 4.16985396269923e-17 NA NA NA hsa-miR-16-5p DLL1 0.246024668671282 0.00346042804503716 -0.293706554700173 0.00827704512535356 miRNATAP -0.466364741606032 2.18878542226134e-13 NA NA NA hsa-miR-193a-3p DLL1 0.395602305834739 0.00182611787714301 -0.293706554700173 0.00827704512535356 miRanda -0.379889186528607 6.12634150644109e-27 NA NA NA hsa-miR-195-3p DLL1 0.100105455903079 0.133362389112338 -0.293706554700173 0.00827704512535356 miRNATAP -0.232307661795269 0.00114251587390255 NA NA NA hsa-miR-199a-5p DLL1 0.174889610847968 0.0900027418912454 -0.293706554700173 0.00827704512535356 miRanda -0.425324414849965 1.88568468541126e-22 NA NA NA hsa-miR-199b-5p DLL1 0.436298593972862 0.00200225454383871 -0.293706554700173 0.00827704512535356 miRanda -0.306777632506273 8.9018246668404e-23 NA NA NA hsa-miR-24-3p DLL1 0.133257261462871 0.212960921400853 -0.293706554700173 0.00827704512535356 miRNATAP -0.379574374232845 4.5444002143314e-16 NA NA NA hsa-miR-320b DLL1 0.283477746304177 0.0005953763020907 -0.293706554700173 0.00827704512535356 miRanda -0.182998972326171 0.00104309430432374 NA NA NA hsa-miR-320c DLL1 0.343259124189966 0.000248338401291051 -0.293706554700173 0.00827704512535356 miRanda -0.197318442482705 9.38061413976053e-05 NA NA NA hsa-miR-330-5p DLL1 -0.262932095995605 0.0465226565966658 -0.293706554700173 0.00827704512535356 miRanda -0.251273206845464 2.30096619918946e-13 NA NA NA hsa-miR-335-5p DLL1 0.0938511632756978 0.336889056387694 -0.293706554700173 0.00827704512535356 miRNAWalker2_validate -0.174723100528941 0.000286745035671802 NA NA NA hsa-miR-34a-5p DLL1 0.143472919835524 0.211283228567057 -0.293706554700173 0.00827704512535356 miRNAWalker2_validate;miRTarBase;miRNATAP -0.588772780693742 2.87430605391173e-57 22438124 Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells lung squamous cell cancer hsa-miR-34c-5p DLL1 0.181931113688093 0.257266965617363 -0.293706554700173 0.00827704512535356 PITA;miRanda;miRNATAP -0.253972226800842 2.53526177834189e-20 NA NA NA hsa-miR-362-3p DLL1 0.032375035235532 0.736465332563774 -0.293706554700173 0.00827704512535356 miRanda -0.293024711728768 6.99930736947713e-10 NA NA NA hsa-miR-423-3p DLL1 0.192317829125882 0.00125622290742326 -0.293706554700173 0.00827704512535356 PITA -0.560469374282965 2.26141317518903e-09 NA NA NA hsa-miR-486-5p DLL1 -0.121638590818052 0.446088157530731 -0.293706554700173 0.00827704512535356 miRanda -0.164856075517514 1.43662918795642e-08 NA NA NA hsa-miR-543 DLL1 -0.347737549779625 0.0157394585079683 -0.293706554700173 0.00827704512535356 miRanda -0.186413892991256 8.7604877125448e-09 NA NA NA hsa-miR-576-5p DLL1 0.106482276040047 0.194379152564166 -0.293706554700173 0.00827704512535356 PITA -0.247316046266817 1.37639412148662e-05 NA NA NA hsa-miR-589-5p DLL1 -0.0382528919634639 0.5844074434222 -0.293706554700173 0.00827704512535356 miRNATAP -0.482530381480198 2.00628105886e-10 NA NA NA hsa-miR-590-3p DLL1 0.312951515438396 0.000480455423843996 -0.293706554700173 0.00827704512535356 PITA;miRanda;mirMAP -0.3749462971117 1.02983983162305e-13 NA NA NA hsa-miR-28-5p DLL3 0.104003572105781 0.153594705579534 -0.712818842894586 8.09586975115036e-05 miRanda -0.940563148614344 2.02813382523444e-17 NA NA NA hsa-miR-421 DLL3 -0.171573235029879 0.0518112933651029 -0.712818842894586 8.09586975115036e-05 miRanda -0.32636432737505 0.000193282779236195 NA NA NA hsa-miR-29a-5p DLL4 -0.0697727833812678 0.350621682973119 0.391779945551827 5.65380343485477e-06 miRNATAP -0.170693605397946 0.000908542574587002 NA NA NA hsa-miR-185-5p DTX3 -0.0767432095218297 0.404113540276816 0.0138686279566542 0.835069704339307 MirTarget -0.12480726376014 4.15231044712225e-06 NA NA NA hsa-miR-124-3p DTX3L -0.506026514549291 0.0078056370358648 0.488852932115728 7.65423567842923e-11 mirMAP -0.129891633736423 1.2383864349311e-15 NA NA NA hsa-miR-139-5p DTX3L -0.647754756897633 2.15378307237163e-06 0.488852932115728 7.65423567842923e-11 miRanda -0.233545653210058 9.4421557803225e-25 NA NA NA hsa-miR-326 DTX3L -0.631050656251074 8.83643450601471e-05 0.488852932115728 7.65423567842923e-11 miRanda -0.108501716794781 1.66348739525085e-08 NA NA NA hsa-miR-340-3p DTX3L -0.107892544857248 0.133625392070518 0.488852932115728 7.65423567842923e-11 MirTarget -0.219143222937665 2.42055694580617e-06 NA NA NA hsa-miR-380-5p DTX3L -0.356387125389103 0.0163515117264043 0.488852932115728 7.65423567842923e-11 mirMAP -0.134839594697289 3.60389054417052e-10 NA NA NA hsa-miR-490-3p DTX3L -0.834268051506884 5.26203010743215e-06 0.488852932115728 7.65423567842923e-11 miRanda -0.154294791080235 3.23732945089801e-20 NA NA NA hsa-miR-495-3p DTX3L -0.421982588962504 0.00504424038526901 0.488852932115728 7.65423567842923e-11 mirMAP -0.123221929423263 2.95985368284735e-09 NA NA NA hsa-miR-7-1-3p DTX3L -0.0894475316162393 0.37322359785108 0.488852932115728 7.65423567842923e-11 mirMAP -0.198956451454775 1.91300610937783e-10 NA NA NA hsa-let-7d-5p DTX4 0.111345229817909 0.0872634398336815 -0.315400806941883 0.000142661170822675 miRNATAP -0.215685311605754 0.000744594152427553 NA NA NA hsa-miR-145-3p DTX4 0.110543172922298 0.294150620210019 -0.315400806941883 0.000142661170822675 mirMAP -0.139607975581394 1.02451022936659e-05 NA NA NA hsa-miR-150-5p DTX4 0.0645271721519611 0.513295658828718 -0.315400806941883 0.000142661170822675 miRNATAP -0.14700089729104 2.96883787934525e-05 NA NA NA hsa-miR-27a-3p DTX4 0.303760032895792 0.00457375391189806 -0.315400806941883 0.000142661170822675 miRNATAP -0.127888939596315 0.000154363681130516 NA NA NA hsa-miR-29b-3p DTX4 -0.178522712044497 0.0856106432165465 -0.315400806941883 0.000142661170822675 miRNATAP -0.104218336483811 0.00401395036753591 NA NA NA hsa-miR-125a-5p DVL2 -0.0833349424517387 0.325440200253607 0.0902324037547402 0.0682410453231654 miRanda -0.250053970863593 4.38364779426917e-27 NA NA NA hsa-miR-221-3p DVL2 -0.0109507285071775 0.936440693394519 0.0902324037547402 0.0682410453231654 miRNAWalker2_validate -0.163493026730553 5.15035042493694e-48 21487968 MiR 221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2; We also suggest that miR-221 may control the migration of AIPC cells through DVL2 working as a key regulator in advanced CaP staging prostate cancer hsa-miR-27a-3p DVL2 0.303760032895792 0.00457375391189806 0.0902324037547402 0.0682410453231654 miRNATAP -0.110653456750655 2.82256030954912e-11 NA NA NA hsa-miR-27b-3p DVL2 -0.0599187745243146 0.58208143475992 0.0902324037547402 0.0682410453231654 miRNATAP -0.172378042250817 1.97856606604285e-26 NA NA NA hsa-miR-28-5p DVL2 0.104003572105781 0.153594705579534 0.0902324037547402 0.0682410453231654 miRanda -0.138180149807161 1.75779834392017e-08 NA NA NA hsa-miR-324-3p DVL2 -0.0103367134443655 0.904494071318044 0.0902324037547402 0.0682410453231654 miRNAWalker2_validate -0.196439931572551 3.33370675639798e-24 NA NA NA hsa-miR-484 DVL2 -0.0190828819137732 0.802298900989652 0.0902324037547402 0.0682410453231654 miRNAWalker2_validate -0.208315082621615 6.40977890057117e-20 NA NA NA hsa-miR-590-5p DVL2 0.16946027035949 0.0386004382081678 0.0902324037547402 0.0682410453231654 miRanda -0.110742788759619 6.49339363263657e-08 NA NA NA hsa-miR-125a-5p DVL3 -0.0833349424517387 0.325440200253607 0.00939128799229039 0.857704514389324 PITA -0.204674238146054 1.44001112830151e-25 NA NA NA hsa-miR-146b-3p DVL3 0.283486177568242 0.0118918188864879 0.00939128799229039 0.857704514389324 MirTarget -0.140794980429694 7.5789655726664e-32 NA NA NA hsa-miR-150-5p DVL3 0.0645271721519611 0.513295658828718 0.00939128799229039 0.857704514389324 MirTarget -0.112833710820738 6.55890443518558e-15 NA NA NA hsa-miR-24-3p DVL3 0.133257261462871 0.212960921400853 0.00939128799229039 0.857704514389324 MirTarget -0.12563498092013 7.08723079700699e-19 NA NA NA hsa-miR-26b-5p DVL3 -0.0984536538762768 0.231803769574623 0.00939128799229039 0.857704514389324 miRNAWalker2_validate -0.136713834505188 1.17845971341915e-11 NA NA NA hsa-miR-29b-2-5p DVL3 -0.26834261955727 0.00453760540520233 0.00939128799229039 0.857704514389324 MirTarget -0.214484906185934 8.22295585996424e-56 NA NA NA hsa-miR-30a-3p DVL3 0.0655410309550977 0.509541256241954 0.00939128799229039 0.857704514389324 MirTarget -0.10131636262252 3.14407615402404e-08 NA NA NA hsa-miR-30e-3p DVL3 0.00173769765874887 0.984965501547409 0.00939128799229039 0.857704514389324 MirTarget -0.197182284592209 9.03229480303599e-23 NA NA NA hsa-miR-330-5p DVL3 -0.262932095995605 0.0465226565966658 0.00939128799229039 0.857704514389324 miRNATAP -0.110031511252826 2.03459869563188e-27 NA NA NA hsa-miR-331-5p DVL3 0.00538076980695534 0.942833685963252 0.00939128799229039 0.857704514389324 PITA;miRNATAP -0.13859874287227 6.14771531743775e-14 NA NA NA hsa-miR-590-5p DVL3 0.16946027035949 0.0386004382081678 0.00939128799229039 0.857704514389324 mirMAP -0.12398843317908 3.52514817672704e-13 NA NA NA hsa-miR-671-5p DVL3 0.379677704170736 0.000129391032677459 0.00939128799229039 0.857704514389324 MirTarget;PITA;miRNATAP -0.110557554277412 7.27891622463238e-16 NA NA NA hsa-miR-149-5p EP300 -0.0535821592029952 0.657713892012548 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate -0.118369420853507 3.40308138671425e-09 NA NA NA hsa-miR-186-5p EP300 0.0606381894130505 0.514217717592464 -0.0809024456519438 0.228129652996621 miRNATAP -0.120697160730751 2.08389735806641e-05 NA NA NA hsa-miR-200b-3p EP300 0.245768526504511 0.0580744465744737 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate;TargetScan -0.113063865997244 1.22732110177343e-09 NA NA NA hsa-miR-200c-3p EP300 0.413752622631695 8.6936333715621e-06 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate;miRNATAP -0.154403328800266 1.16945030241261e-09 NA NA NA hsa-miR-22-3p EP300 0.0277287593466351 0.809325106832648 -0.0809024456519438 0.228129652996621 MirTarget;miRNATAP -0.129040932214718 7.43865109883095e-06 NA NA NA hsa-miR-2355-3p EP300 0.186207523505296 0.0525918026993012 -0.0809024456519438 0.228129652996621 MirTarget;miRNATAP -0.10892387366383 1.09126064579299e-05 NA NA NA hsa-miR-26b-5p EP300 -0.0984536538762768 0.231803769574623 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate;miRNATAP -0.146408928599053 2.57076047853747e-05 NA NA NA hsa-miR-29b-1-5p EP300 0.191335428755774 0.00846436454790702 -0.0809024456519438 0.228129652996621 MirTarget -0.110260412848281 0.000822430640380143 NA NA NA hsa-miR-30c-5p EP300 -0.0469114469943097 0.565934557464627 -0.0809024456519438 0.228129652996621 miRNAWalker2_validate -0.312468973887759 2.06637782937568e-17 NA NA NA hsa-miR-339-5p EP300 0.273253751377152 0.0185300170790638 -0.0809024456519438 0.228129652996621 miRanda -0.139872022902314 5.63823302029633e-12 NA NA NA hsa-miR-342-3p EP300 -0.125683829770877 0.105810751640137 -0.0809024456519438 0.228129652996621 MirTarget;PITA;miRanda;miRNATAP -0.186971239869884 5.16619501373405e-08 NA NA NA hsa-miR-361-3p EP300 -0.0798653643614555 0.271064714084553 -0.0809024456519438 0.228129652996621 PITA -0.179432283394391 1.94960435203698e-06 NA NA NA hsa-miR-574-3p EP300 0.254057161073935 0.0219522676746007 -0.0809024456519438 0.228129652996621 PITA -0.118613580916583 3.76846499771262e-08 NA NA NA hsa-miR-590-3p EP300 0.312951515438396 0.000480455423843996 -0.0809024456519438 0.228129652996621 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.112448802446131 2.42909707997915e-05 NA NA NA hsa-miR-125b-2-3p HDAC2 -0.0775572585326127 0.381771874712035 0.117454388089981 0.0275001149595677 mirMAP -0.135068729475954 8.74704792504135e-10 NA NA NA hsa-miR-200b-3p HDAC2 0.245768526504511 0.0580744465744737 0.117454388089981 0.0275001149595677 mirMAP -0.108134796730082 7.60970721804197e-15 NA NA NA hsa-miR-22-5p HDAC2 0.0437233965539527 0.639996108995995 0.117454388089981 0.0275001149595677 mirMAP -0.135686893658284 2.23479196555191e-12 NA NA NA hsa-miR-30a-3p HDAC2 0.0655410309550977 0.509541256241954 0.117454388089981 0.0275001149595677 mirMAP -0.238056758666704 1.07148980415189e-25 NA NA NA hsa-miR-30a-5p HDAC2 -0.062942936611238 0.513851954700252 0.117454388089981 0.0275001149595677 mirMAP -0.380194072408458 1.03603493573615e-39 NA NA NA hsa-miR-30b-5p HDAC2 -0.0858101016322106 0.263243418521854 0.117454388089981 0.0275001149595677 mirMAP -0.107304218134878 0.000164298888604299 NA NA NA hsa-miR-30c-5p HDAC2 -0.0469114469943097 0.565934557464627 0.117454388089981 0.0275001149595677 mirMAP -0.175389058087692 5.44225528673309e-10 NA NA NA hsa-miR-30d-3p HDAC2 0.0854049347792898 0.20691254801121 0.117454388089981 0.0275001149595677 mirMAP -0.121864269874971 6.02521665649186e-06 NA NA NA hsa-miR-30d-5p HDAC2 -0.0607010868720046 0.471410043548794 0.117454388089981 0.0275001149595677 mirMAP -0.224918302149881 2.29145076227404e-12 NA NA NA hsa-miR-30e-3p HDAC2 0.00173769765874887 0.984965501547409 0.117454388089981 0.0275001149595677 mirMAP -0.178495670225385 1.53763140782324e-11 NA NA NA hsa-miR-30e-5p HDAC2 0.0764521828640934 0.41904991629622 0.117454388089981 0.0275001149595677 mirMAP -0.156994014679323 4.22533409188184e-09 NA NA NA hsa-miR-361-5p HDAC2 0.0107519600643302 0.882230614095565 0.117454388089981 0.0275001149595677 mirMAP -0.102733579511706 0.000935763380066312 NA NA NA hsa-miR-92b-3p HDAC2 -0.213968504161963 0.0523921855715716 0.117454388089981 0.0275001149595677 mirMAP -0.108197780966655 1.11181974623557e-08 NA NA NA hsa-miR-15b-5p HES5 0.592863156692837 1.41971517354055e-10 -0.446806613005381 0.0169959642965194 mirMAP -0.506080121619016 3.82210311519337e-08 NA NA NA hsa-miR-455-5p HES5 0.332224239762 0.0106491358056238 -0.446806613005381 0.0169959642965194 miRNATAP -0.448715816977926 3.30076135048886e-13 NA NA NA hsa-miR-501-5p HES5 0.0878951859817452 0.309663377222443 -0.446806613005381 0.0169959642965194 PITA;miRNATAP -0.523219355131325 2.69967177526411e-08 NA NA NA hsa-miR-124-3p JAG1 -0.506026514549291 0.0078056370358648 0.587520818551891 2.62406718255098e-12 MirTarget;miRNATAP -0.119554728715271 3.64716224431693e-11 NA NA NA hsa-miR-128-3p JAG1 -0.781932174412672 7.1812756321342e-10 0.587520818551891 2.62406718255098e-12 MirTarget -0.28884114848186 4.23791345007622e-24 NA NA NA hsa-miR-129-5p JAG1 -0.567133990117126 0.00116152215679936 0.587520818551891 2.62406718255098e-12 PITA;miRanda;miRNATAP -0.146180096254993 2.16509743563399e-13 NA NA NA hsa-miR-137 JAG1 -0.924849266740909 1.546832202049e-06 0.587520818551891 2.62406718255098e-12 miRanda -0.161305650531434 6.51649793572493e-21 NA NA NA hsa-miR-140-3p JAG1 -0.123864258867705 0.14796686619449 0.587520818551891 2.62406718255098e-12 MirTarget;PITA;miRNATAP -0.158615194305729 0.00326388276362267 NA NA NA hsa-miR-153-3p JAG1 -0.173449510253619 0.0654368045743418 0.587520818551891 2.62406718255098e-12 MirTarget -0.191630435054983 5.48683496979272e-07 NA NA NA hsa-miR-342-3p JAG1 -0.125683829770877 0.105810751640137 0.587520818551891 2.62406718255098e-12 miRanda -0.168849395510418 0.00078437997224144 NA NA NA hsa-miR-361-3p JAG1 -0.0798653643614555 0.271064714084553 0.587520818551891 2.62406718255098e-12 miRNATAP -0.184522061300518 0.000799927020817679 NA NA NA hsa-miR-375 JAG1 -0.0268401141324031 0.858358101444697 0.587520818551891 2.62406718255098e-12 miRNAWalker2_validate -0.101353729878028 9.83767978444936e-06 NA NA NA hsa-miR-485-3p JAG1 -0.530677478972593 0.00148549219838911 0.587520818551891 2.62406718255098e-12 MirTarget;PITA;miRNATAP -0.114779137970637 2.10284830535746e-08 NA NA NA hsa-miR-490-3p JAG1 -0.834268051506884 5.26203010743215e-06 0.587520818551891 2.62406718255098e-12 miRanda -0.163289933194028 1.20492489703191e-18 NA NA NA hsa-miR-495-3p JAG1 -0.421982588962504 0.00504424038526901 0.587520818551891 2.62406718255098e-12 MirTarget;mirMAP -0.110940476328272 1.43953924054739e-06 NA NA NA hsa-miR-598-3p JAG1 -0.122995501125271 0.149608857102587 0.587520818551891 2.62406718255098e-12 MirTarget -0.165007037585308 0.000298273641925654 NA NA NA hsa-miR-155-5p KAT2A 0.969837380981085 5.86551495710056e-15 -0.115821851494959 0.161066004112681 miRNATAP -0.190769126220108 5.14281109537036e-14 NA NA NA hsa-miR-331-3p KAT2A 0.0126984726684189 0.905175053956974 -0.115821851494959 0.161066004112681 miRNAWalker2_validate -0.362734142759807 5.75191126329473e-35 NA NA NA hsa-miR-342-3p KAT2A -0.125683829770877 0.105810751640137 -0.115821851494959 0.161066004112681 MirTarget;miRanda -0.207479243381259 1.26916008833531e-05 NA NA NA hsa-miR-365a-3p KAT2A -0.184222766207919 0.0292663235724171 -0.115821851494959 0.161066004112681 miRNATAP -0.145349743206459 0.000284965692675852 NA NA NA hsa-miR-550a-5p KAT2A 0.446742576641774 3.20431264038718e-06 -0.115821851494959 0.161066004112681 MirTarget -0.180033420785823 1.12459632818691e-07 NA NA NA hsa-miR-106b-5p KAT2B 0.167096183547615 0.0497544396383451 -0.177763979547981 0.00490249161746619 miRNAWalker2_validate;miRTarBase;MirTarget -0.170510176386408 1.74410561327957e-09 NA NA NA hsa-miR-17-5p KAT2B 0.0975751369167082 0.20621110214601 -0.177763979547981 0.00490249161746619 MirTarget;TargetScan -0.14015005656944 4.99125519610182e-05 23095762 miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of PCAF by miR-17-5p was evaluated using the luciferase reporter assay; Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; PCAF is upregulated in cultured PCa cells and upregulation of PCAF is associated with the downregulation of miR-17-5p; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells prostate cancer hsa-miR-19a-3p KAT2B 0.0466707843731911 0.576818938277755 -0.177763979547981 0.00490249161746619 miRNAWalker2_validate -0.100985256522731 0.000179107047726342 NA NA NA hsa-miR-19b-3p KAT2B -0.0138427450847924 0.856506310673067 -0.177763979547981 0.00490249161746619 miRNAWalker2_validate -0.109507535380128 0.000661807842943337 NA NA NA hsa-miR-25-3p KAT2B 0.316649850160985 0.000777982468387578 -0.177763979547981 0.00490249161746619 miRNAWalker2_validate;miRTarBase;MirTarget -0.146152740428526 8.6118044226559e-07 NA NA NA hsa-miR-342-3p KAT2B -0.125683829770877 0.105810751640137 -0.177763979547981 0.00490249161746619 miRanda -0.127940959795952 3.69730815761415e-05 NA NA NA hsa-miR-361-5p KAT2B 0.0107519600643302 0.882230614095565 -0.177763979547981 0.00490249161746619 miRanda -0.147882196468876 5.80696051531007e-05 NA NA NA hsa-miR-374a-3p KAT2B 0.176226170437625 0.0343958848425446 -0.177763979547981 0.00490249161746619 MirTarget -0.131109206411983 4.62821874734242e-05 NA NA NA hsa-miR-450b-5p KAT2B 0.270544879013992 0.00801537838499562 -0.177763979547981 0.00490249161746619 MirTarget;miRNATAP -0.108744989149976 3.1483232866511e-07 NA NA NA hsa-miR-542-3p KAT2B 0.0835995677900829 0.403838744494071 -0.177763979547981 0.00490249161746619 miRanda -0.144571589147993 7.94315947961484e-10 NA NA NA hsa-miR-576-5p KAT2B 0.106482276040047 0.194379152564166 -0.177763979547981 0.00490249161746619 mirMAP -0.140325532094892 1.05780051038544e-07 NA NA NA hsa-miR-92a-3p KAT2B 0.0407239381334659 0.643983393805961 -0.177763979547981 0.00490249161746619 miRNAWalker2_validate;MirTarget -0.109236258737639 0.00513827783562479 NA NA NA hsa-miR-93-5p KAT2B 0.139766237971122 0.101057320076629 -0.177763979547981 0.00490249161746619 miRNAWalker2_validate;miRTarBase;MirTarget -0.215416054908579 2.44077740231659e-08 NA NA NA hsa-miR-107 LFNG -0.121070851008387 0.198381281894242 -0.0502712976032305 0.650684054786518 miRanda -0.139812294181844 0.00833997392397171 NA NA NA hsa-miR-195-5p LFNG -0.00728332132631593 0.92969850577609 -0.0502712976032305 0.650684054786518 mirMAP -0.201237432426496 0.00110257511663352 NA NA NA hsa-miR-2355-5p MAML1 0.00808596988211185 0.916165501155096 0.0879350741375164 0.0635150830048929 MirTarget -0.15816675191117 1.21239123844506e-14 NA NA NA hsa-miR-23b-3p MAML1 0.0476610245860094 0.630277683372344 0.0879350741375164 0.0635150830048929 MirTarget;miRNATAP -0.125029053114432 1.7209639693681e-13 NA NA NA hsa-miR-30a-5p MAML1 -0.062942936611238 0.513851954700252 0.0879350741375164 0.0635150830048929 MirTarget;miRNATAP -0.181578949230147 1.84105112608285e-12 NA NA NA hsa-miR-30b-5p MAML1 -0.0858101016322106 0.263243418521854 0.0879350741375164 0.0635150830048929 MirTarget -0.1263316763531 1.22167268644127e-07 NA NA NA hsa-miR-30c-5p MAML1 -0.0469114469943097 0.565934557464627 0.0879350741375164 0.0635150830048929 MirTarget;miRNATAP -0.129840720221565 5.99715560171768e-08 NA NA NA hsa-miR-30d-5p MAML1 -0.0607010868720046 0.471410043548794 0.0879350741375164 0.0635150830048929 MirTarget;miRNATAP -0.156698087643227 9.1407360471927e-09 NA NA NA hsa-miR-125a-3p MAML2 0.183834985432376 0.106230647107917 -0.0905756396747606 0.385843214879373 miRanda -0.138589490052315 0.0002951337341041 NA NA NA hsa-miR-126-5p MAML2 0.177332403948664 0.0711675116243123 -0.0905756396747606 0.385843214879373 mirMAP -0.170477042415141 0.000205134437473632 NA NA NA hsa-miR-140-3p MAML2 -0.123864258867705 0.14796686619449 -0.0905756396747606 0.385843214879373 PITA -0.242740791881478 0.000270443581399761 NA NA NA hsa-miR-324-5p MAML2 0.0183370482495953 0.842996782677271 -0.0905756396747606 0.385843214879373 miRanda -0.284865744896696 1.47910474179749e-09 NA NA NA hsa-miR-330-5p MAML2 -0.262932095995605 0.0465226565966658 -0.0905756396747606 0.385843214879373 miRanda -0.157195488880705 1.28165156553027e-06 NA NA NA hsa-miR-335-5p MAML2 0.0938511632756978 0.336889056387694 -0.0905756396747606 0.385843214879373 miRNAWalker2_validate -0.12938563035386 0.00409920188890029 NA NA NA hsa-miR-491-5p MAML2 -0.749881113074983 8.22859263179194e-09 -0.0905756396747606 0.385843214879373 miRanda -0.124659683546096 0.000119038635745493 NA NA NA hsa-miR-543 MAML2 -0.347737549779625 0.0157394585079683 -0.0905756396747606 0.385843214879373 miRanda -0.184286489786944 1.03080975742354e-09 NA NA NA hsa-miR-576-5p MAML2 0.106482276040047 0.194379152564166 -0.0905756396747606 0.385843214879373 mirMAP -0.161075381135013 0.0025348145880436 NA NA NA hsa-miR-590-3p MAML2 0.312951515438396 0.000480455423843996 -0.0905756396747606 0.385843214879373 mirMAP -0.195763324748148 4.42042468968499e-05 NA NA NA hsa-miR-664a-3p MAML2 0.0413918462467198 0.611334357897022 -0.0905756396747606 0.385843214879373 mirMAP -0.49795079803461 2.21894219780716e-21 NA NA NA hsa-miR-125a-5p NCOR2 -0.0833349424517387 0.325440200253607 -0.0539819339668544 0.427653478051333 MirTarget;PITA;miRanda -0.182796912590237 4.13045142081108e-09 NA NA NA hsa-miR-125b-5p NCOR2 -0.0119698382910496 0.890233923197358 -0.0539819339668544 0.427653478051333 MirTarget;miRNATAP -0.15359160152224 4.47189271124535e-05 NA NA NA hsa-miR-16-5p NCOR2 0.246024668671282 0.00346042804503716 -0.0539819339668544 0.427653478051333 miRNAWalker2_validate;miRTarBase -0.115516933757695 0.000135274337065658 NA NA NA hsa-miR-200b-3p NCOR2 0.245768526504511 0.0580744465744737 -0.0539819339668544 0.427653478051333 TargetScan -0.120690711438893 3.9356519617989e-13 NA NA NA hsa-miR-29b-3p NCOR2 -0.178522712044497 0.0856106432165465 -0.0539819339668544 0.427653478051333 miRNATAP -0.167627591040107 2.04770312850153e-13 NA NA NA hsa-miR-29c-3p NCOR2 -0.372180390387259 0.00202634431973208 -0.0539819339668544 0.427653478051333 miRNATAP -0.145447332978375 4.27444777102117e-14 NA NA NA hsa-miR-30a-5p NCOR2 -0.062942936611238 0.513851954700252 -0.0539819339668544 0.427653478051333 miRNATAP -0.269011633271402 1.20310576408398e-13 NA NA NA hsa-miR-30c-5p NCOR2 -0.0469114469943097 0.565934557464627 -0.0539819339668544 0.427653478051333 miRNATAP -0.170643423223496 4.71453383883123e-07 NA NA NA hsa-miR-30d-5p NCOR2 -0.0607010868720046 0.471410043548794 -0.0539819339668544 0.427653478051333 miRNATAP -0.139091383479749 0.000343496035426651 NA NA NA hsa-miR-331-3p NCOR2 0.0126984726684189 0.905175053956974 -0.0539819339668544 0.427653478051333 miRNATAP -0.13927134887292 5.06673586881918e-12 NA NA NA hsa-miR-339-5p NCOR2 0.273253751377152 0.0185300170790638 -0.0539819339668544 0.427653478051333 miRanda -0.119290773637356 7.55269449800804e-11 NA NA NA hsa-miR-34a-5p NCOR2 0.143472919835524 0.211283228567057 -0.0539819339668544 0.427653478051333 MirTarget -0.16579175952528 6.98221127814608e-19 NA NA NA hsa-miR-101-3p NOTCH1 -0.132333931567244 0.241891922291381 -0.021675781444384 0.784456320866891 MirTarget -0.187416719240291 1.0940497082962e-08 NA NA NA hsa-miR-139-5p NOTCH1 -0.647754756897633 2.15378307237163e-06 -0.021675781444384 0.784456320866891 PITA;miRanda;miRNATAP -0.126275438431501 3.97588150952362e-09 27173050;25149074;26299922;27738333;24885920 miR 139 5p sensitizes colorectal cancer cells to 5 fluorouracil by targeting NOTCH 1;MiR 139 5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1; Mechanistic investigations revealed that miR-139-5p suppress CRC cell invasion and metastasis by targeting AMFR and NOTCH1;MiR 139 5p inhibits the biological function of breast cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel; MiR-139-5p expression in MCF-7 MCF-7/Doc cells and in selected breast cancer tissue samples was confirmed by real-time PCR; cell viability was analyzed by Cell Counting Kit-8 assay; apoptosis and cell cycle were analyzed by flow cytometry; control of metastasis and invasion of breast cancer cells was measured by transwell assay; expression of Notch1 was measured by western blot; a luciferase reporter vector was constructed to identify the miR-139-5p target gene; MiR-139-5p not only attenuated the development of breast cancer cells but also mediated drug-resistance by regulating the expression of the downstream target gene Notch1;MiR 139 5p reverses CD44+/CD133+ associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells; We also identified NOTCH1 an important protein for stem cell maintenance and function as a direct target of miR-139-5p both in vitro and in a knockout mouse model; Notch1 expression was upregulated in tumor samples and inversely correlated with expression of miR-139-5p; Silencing NOTCH1 exerted an effect similar to overexpression of miR-139-5p by inhibiting the CD44+ and CD133+ population and reversing the drug-resistant phenotype; In conclusion miR-139-5p downregulated NOTCH1 signaling to reverse CD44+/CD133+-associated MDR in colorectal cancer cells;microRNA 139 5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer ;metastasis;metastasis;drug resistance;drug resistance; colorectal cancer;colorectal cancer;breast cancer;colorectal cancer;colorectal cancer hsa-miR-199a-5p NOTCH1 0.174889610847968 0.0900027418912454 -0.021675781444384 0.784456320866891 miRanda -0.223141716427289 6.43002034730432e-16 NA NA NA hsa-miR-199b-5p NOTCH1 0.436298593972862 0.00200225454383871 -0.021675781444384 0.784456320866891 miRanda -0.148099403035626 9.02018277805841e-14 24659709 Epigenetic silencing of microRNA 199b 5p is associated with acquired chemoresistance via activation of JAG1 Notch1 signaling in ovarian cancer; Here we report that the loss of miR-199b-5p due to progressive epigenetic silencing leads to the activation of the JAG1-mediated Notch1 signaling cascade thereby leading to the development of acquired chemoresistance in ovarian cancer drug resistance;progression ovarian cancer hsa-miR-200b-3p NOTCH1 0.245768526504511 0.0580744465744737 -0.021675781444384 0.784456320866891 MirTarget;TargetScan -0.208194895947003 1.36204710092618e-21 26012256;23430952 Nobiletin inhibited hypoxia induced epithelial mesenchymal transition of lung cancer cells by inactivating of Notch 1 signaling and switching on miR 200b; Our findings suggest that downregulation of Notch-1 and reexpression of miR-200b by nobiletin might be a novel remedy for the therapy of lung cancer;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis ; lung cancer;sarcoma hsa-miR-200c-3p NOTCH1 0.413752622631695 8.6936333715621e-06 -0.021675781444384 0.784456320866891 MirTarget -0.223317170493912 1.59468039606813e-13 NA NA NA hsa-miR-2355-5p NOTCH1 0.00808596988211185 0.916165501155096 -0.021675781444384 0.784456320866891 MirTarget -0.379997968696284 1.17598104591566e-23 NA NA NA hsa-miR-23b-3p NOTCH1 0.0476610245860094 0.630277683372344 -0.021675781444384 0.784456320866891 miRNAWalker2_validate;miRTarBase -0.315065111358011 7.25440212558849e-24 NA NA NA hsa-miR-24-3p NOTCH1 0.133257261462871 0.212960921400853 -0.021675781444384 0.784456320866891 miRNAWalker2_validate;miRTarBase -0.25201904466456 4.00584083162083e-18 NA NA NA hsa-miR-27b-3p NOTCH1 -0.0599187745243146 0.58208143475992 -0.021675781444384 0.784456320866891 miRNAWalker2_validate;miRTarBase -0.268442320679108 1.80808420510082e-21 NA NA NA hsa-miR-28-5p NOTCH1 0.104003572105781 0.153594705579534 -0.021675781444384 0.784456320866891 miRanda -0.35339179425784 1.51695440792741e-17 NA NA NA hsa-miR-30a-5p NOTCH1 -0.062942936611238 0.513851954700252 -0.021675781444384 0.784456320866891 miRNAWalker2_validate;miRTarBase;miRNATAP -0.42323267898728 1.02834042721951e-18 NA NA NA hsa-miR-30b-5p NOTCH1 -0.0858101016322106 0.263243418521854 -0.021675781444384 0.784456320866891 miRNATAP -0.27287127782669 1.12822373944111e-09 NA NA NA hsa-miR-30c-5p NOTCH1 -0.0469114469943097 0.565934557464627 -0.021675781444384 0.784456320866891 miRNATAP -0.376813230277597 1.64124274123235e-17 23974200 We identified NOTCH1 as a direct target of miR-30c; Finally a block of miR-30c prevents C/EBPα-induced downregulation of Notch1 protein and leads to a reduced CD11b expression in myeloid differentiation; Our study presents the first evidence that C/EBPα miR-30c and Notch1 together play a critical role in granulocytic differentiation and AML and particularly in AML with CEBPA mutations differentiation acute myeloid leukemia hsa-miR-30d-5p NOTCH1 -0.0607010868720046 0.471410043548794 -0.021675781444384 0.784456320866891 miRNATAP -0.363186371240126 1.0261492743008e-12 NA NA NA hsa-miR-32-5p NOTCH1 0.130313603388223 0.177843055266148 -0.021675781444384 0.784456320866891 miRNATAP -0.154149569248209 3.2042444497718e-07 NA NA NA hsa-miR-34a-5p NOTCH1 0.143472919835524 0.211283228567057 -0.021675781444384 0.784456320866891 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.282796793876507 2.68894872856004e-31 21743299;22438124;23140286;24349627;24565525;25783790;20351093;27082152;23642368;22347519;23430952;23902763;22992310;23145211;25623761;23085450 MicroRNA 34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme; Also we identified notch1 as a direct target gene of miR-34a; Knockdown of notch1 showed similar cellular functions as overexpression of miR-34a both in vitro and in vivo; Collectively our findings show that miR-34a is downregulated in GBM cells and inhibits GBM growth by targeting notch1;Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells; In our study using miRNA microarray we observed that downregulation of the Notch-1 pathway by delta-tocotrienol correlated with upregulation of miR-34a in nonsmall cell lung cancer cells NSCLC;We found that Re-expression forced expression of miR-34a inhibits cell growth and induces apoptosis with concomitant down-regulation of Notch-1 signaling pathway one of the target of miR-34a; Moreover treatment of PC cells with a natural compound genistein led to the up-regulation of miR-34a resulting in the down-regulation of Notch-1 which was correlated with inhibition of cell growth and induction of apoptosis;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed reexpression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;In addition intracellular restoration of miR-34a inhibited breast cancer cell migration via targeting Notch-1 signaling;MicroRNA 34a suppresses the breast cancer stem cell like characteristics by downregulating Notch1 pathway; In this study we verified that miR-34a directly and functionally targeted Notch1 in MCF-7 cells; We reported that miR-34a negatively regulated cell proliferation migration and invasion and breast cancer stem cell propagation by downregulating Notch1; The expression of miR-34a was negatively correlated with tumor stages metastasis and Notch1 expression in breast cancer tissues; Furthermore overexpression of miR-34a increased chemosensitivity of breast cancer cells to paclitaxel PTX by downregulating the Notch1 pathway; Taken together our results indicate that miR-34a inhibited breast cancer stemness and increased the chemosensitivity to PTX partially by downregulating the Notch1 pathway suggesting that miR-34a/Notch1 play an important role in regulating breast cancer stem cells;MicroRNA 34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells; Computational miRNA target prediction suggested that Notch1 and Jagged1 were targets of miR-34a; By using functional assays miR-34a was demonstrated to bind to the 3' untranslated regions of Notch1 and Jagged1; Forced expression of miR-34a altered the expression of Notch1 and Jagged1 protein as well as Notch signaling as shown by the response of Hairy Enhancer of Split-1 protein to these treatments using western blot analysis;We showed that miR-34a as a tumor suppressor could separately reduce the stemness of BCSCs and activate the cytotoxic susceptibility of BCSCs to natural killer NK cells in vitro via down regulating the expression of Notch1 signaling molecules;Mechanistically miR-34a sequesters Notch1 mRNA to generate a sharp threshold response where a bimodal Notch signal specifies the choice between self-renewal and differentiation;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed re-expression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis;Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial mesenchymal transition EMT by miR 34a mediated suppression of Notch 1 expression in non small cell lung cancer cell lines; Indeed rhamnetin and cirsiliol increased the expression of tumor-suppressive microRNA miR-34a in a p53-dependent manner leading to inhibition of Notch-1 expression;The re-expression of miR-34 led to a marked reduction in the expression of its target gene Notch-1;Inactivation of AR and Notch 1 signaling by miR 34a attenuates prostate cancer aggressiveness; We found that over-expression of miR-34a led to reduced expression of AR PSA and Notch-1; These findings suggest that the loss of miR-34a is directly linked with up-regulation of AR and Notch-1 both of which are highly expressed in PCa and thus finding innovative approaches by which miR-34a expression could be up-regulated will have a huge impact on the treatment of PCa especially for the treatment of mCRPC;miR 34a may regulate sensitivity of breast cancer cells to adriamycin via targeting Notch1; To explore the influence of miR-34a on Notch1 expression in breast cancer cells and to explore the role of miR-34a in the sensitivity of breast cancer cells to Adriamycin ADR; The expression levels of Notch1 mRNA and protein in MCF-7/ADR cells transfected with miR-34a mimics were significantly up-regulated; On the contrary the expressions of Notch1 mRNA and protein in MCF-7 cells transfected with miR-34a inhibitor were down-regulated; miR-34a negatively regulates the expression of Notch1 at both mRNA and protein levels;MicroRNA 34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting Notch1; The association of miR-34a and Notch1 was analyzed by dual-luciferase reporter assay and Notch1-siRNA technology; Real-time PCR assay was performed to test the expression of miR-34a and Notch1 in 38 selective breast cancer tissue samples; MiR-34a mimic could inhibit the luciferase activity of the construct containing wild-type 3' UTR of Notch1 in MCF-7/ADR cells; Further there was an inverse association between Notch1 and miR-34a expression in breast cancer; Dysregulation of miR-34a plays critical roles in the acquired ADR resistance of breast cancer at least in part via targeting Notch1 ;;;;cell migration;staging;metastasis;drug resistance;;differentiation;drug resistance;;;;;;;drug resistance glioblastoma;lung squamous cell cancer;pancreatic cancer;prostate cancer;breast cancer;breast cancer;cervical and endocervical cancer;breast cancer;colon cancer;prostate cancer;sarcoma;lung squamous cell cancer;colon cancer;prostate cancer;breast cancer;breast cancer hsa-miR-34c-5p NOTCH1 0.181931113688093 0.257266965617363 -0.021675781444384 0.784456320866891 miRNAWalker2_validate;miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.107537464613802 8.92317727559482e-10 24802328 Taken together our data indicate that miR-34c suppresses OS metastasis and chemoresistance by targeting Notch1 and LEF1 metastasis;drug resistance sarcoma hsa-miR-369-3p NOTCH1 -0.153496605399658 0.296055925448078 -0.021675781444384 0.784456320866891 PITA -0.157623336163144 1.88500406617029e-16 NA NA NA hsa-miR-582-5p NOTCH1 -0.215764335500665 0.0760892640434509 -0.021675781444384 0.784456320866891 PITA;miRNATAP -0.122147705388324 1.65996696375078e-07 NA NA NA hsa-miR-1-3p NOTCH2 -0.218035884810576 0.125196862509753 0.0265373761477177 0.759991465966744 MirTarget -0.123736651017436 2.39217098657886e-08 NA NA NA hsa-miR-106a-5p NOTCH2 0.110074064773897 0.13045815990621 0.0265373761477177 0.759991465966744 miRNAWalker2_validate -0.204397218316821 1.12592965432191e-05 NA NA NA hsa-miR-146b-5p NOTCH2 0.441078059667297 0.000237619929889385 0.0265373761477177 0.759991465966744 miRanda -0.135030486429014 1.19722662261533e-06 NA NA NA hsa-miR-15a-5p NOTCH2 0.142658985373611 0.0536219185009004 0.0265373761477177 0.759991465966744 MirTarget -0.218279376305313 3.06264100050065e-05 NA NA NA hsa-miR-181a-5p NOTCH2 -0.178215604431845 0.0700010802255601 0.0265373761477177 0.759991465966744 miRNAWalker2_validate;MirTarget;mirMAP -0.131391300525628 0.00333206348449474 NA NA NA hsa-miR-181b-5p NOTCH2 0.0260899284211646 0.768941836912518 0.0265373761477177 0.759991465966744 MirTarget;mirMAP -0.219029917313777 1.08484264906831e-06 NA NA NA hsa-miR-29b-3p NOTCH2 -0.178522712044497 0.0856106432165465 0.0265373761477177 0.759991465966744 MirTarget -0.100449994874329 0.00373643393819674 NA NA NA hsa-miR-34a-5p NOTCH2 0.143472919835524 0.211283228567057 0.0265373761477177 0.759991465966744 miRNAWalker2_validate;miRNATAP -0.155403367407081 4.43885179634091e-08 NA NA NA hsa-miR-34c-5p NOTCH2 0.181931113688093 0.257266965617363 0.0265373761477177 0.759991465966744 PITA;miRanda;miRNATAP -0.136628313778413 1.9632919924199e-12 NA NA NA hsa-miR-9-5p NOTCH2 -0.125377971246422 0.269896477802284 0.0265373761477177 0.759991465966744 miRNATAP -0.224744730633258 0.00141456310007709 NA NA NA hsa-miR-660-5p NOTCH3 -0.138989893523975 0.0945491063873448 0.272080567335002 0.000427079004627279 MirTarget -0.104787422927821 0.00769959006252018 NA NA NA hsa-miR-181c-5p NOTCH4 -0.285631740307867 0.00281600994521758 0.198618945728854 0.000266531453702477 miRNAWalker2_validate;miRTarBase -0.106661159221485 1.60550302405283e-05 NA NA NA hsa-miR-342-3p NOTCH4 -0.125683829770877 0.105810751640137 0.198618945728854 0.000266531453702477 miRanda -0.12051064590869 8.64843198973487e-05 NA NA NA hsa-miR-491-5p NOTCH4 -0.749881113074983 8.22859263179194e-09 0.198618945728854 0.000266531453702477 miRanda -0.106294441180889 1.56842236514337e-11 NA NA NA hsa-let-7e-5p RBPJ 0.0471189209570344 0.657255455444655 0.00383693564086229 0.953144771006534 miRNATAP -0.127731305944253 2.1380353960429e-06 NA NA NA hsa-miR-132-3p RBPJ -0.178379362833856 0.13335200877129 0.00383693564086229 0.953144771006534 mirMAP -0.120649442556272 2.15847861295186e-08 NA NA NA hsa-miR-155-5p RBPJ 0.969837380981085 5.86551495710056e-15 0.00383693564086229 0.953144771006534 miRNAWalker2_validate -0.127852993406769 1.12206123408632e-11 NA NA NA hsa-miR-200b-3p RBPJ 0.245768526504511 0.0580744465744737 0.00383693564086229 0.953144771006534 mirMAP -0.124078499079245 5.1195361414368e-11 NA NA NA hsa-miR-200c-3p RBPJ 0.413752622631695 8.6936333715621e-06 0.00383693564086229 0.953144771006534 mirMAP -0.103079825781586 7.86991513553507e-05 NA NA NA hsa-miR-22-5p RBPJ 0.0437233965539527 0.639996108995995 0.00383693564086229 0.953144771006534 MirTarget;miRNATAP -0.201033751803788 8.58249817231906e-15 NA NA NA hsa-miR-361-5p RBPJ 0.0107519600643302 0.882230614095565 0.00383693564086229 0.953144771006534 miRanda -0.120283834254296 0.00407684069176925 NA NA NA hsa-miR-543 RBPJ -0.347737549779625 0.0157394585079683 0.00383693564086229 0.953144771006534 miRanda;mirMAP;miRNATAP -0.103649888259231 1.34897232166163e-09 NA NA NA hsa-miR-664a-3p RBPJ 0.0413918462467198 0.611334357897022 0.00383693564086229 0.953144771006534 mirMAP -0.232772661445295 1.10350854879674e-14 NA NA NA hsa-miR-7-1-3p RBPJ -0.0894475316162393 0.37322359785108 0.00383693564086229 0.953144771006534 mirMAP -0.132140476428887 5.28193702118985e-08 NA NA NA