miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-21-5p TET1 2.32007501846389 3.08394781855554e-137 -0.560839118524932 2.47023070053678e-06 miRNAWalker2_validate -0.219366694016521 3.08336716646783e-09 NA NA NA hsa-miR-29a-3p TET1 -0.699539666833076 1.13935003139957e-13 -0.560839118524932 2.47023070053678e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.121055322616723 0.00497623456890235 27555295;25367851;25616722 Furthermore data from bioinformatic analysis validated by dual-luciferase reporter gene assay showed that ten eleven translocation 1 TET1 was a direct target of miR-29a and over-expression of TET1 inhibited cell proliferation and migration which could be induced by the up-regulation of miR-29a; MiR-29a targets TET1 down regulates its expression and thus promotes EMT in breast cancer; Altogether we demonstrate that miR-29a acts as a tumor activator by targeting TET1 and induces cell proliferation and EMT in breast cancer;Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; MiR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression;Erratum to: Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; miR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression ;metastasis;progression;tumorigenesis;metastasis;progression;tumorigenesis breast cancer;liver cancer;liver cancer hsa-miR-29b-3p TET1 0.438847962603729 6.46722433236121e-05 -0.560839118524932 2.47023070053678e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.16104208480761 1.50396462937635e-05 25367851;25616722 Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; MiR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression;Erratum to: Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; miR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression metastasis;progression;tumorigenesis;metastasis;progression;tumorigenesis liver cancer;liver cancer hsa-miR-29c-3p TET1 -0.0652732378039769 0.563774115756922 -0.560839118524932 2.47023070053678e-06 MirTarget;miRNATAP -0.411917359075481 7.16963817256472e-32 NA NA NA hsa-miR-342-3p TET1 1.21944481975657 6.81914373001202e-19 -0.560839118524932 2.47023070053678e-06 miRanda -0.1159129829026 7.11329052918399e-05 NA NA NA