miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-3p ABI3BP 1.42015538786275 7.03375209382654e-13 -4.28101892502181 3.69754693029295e-18 miRNATAP -0.980869857195845 1.9510516325014e-16 NA NA NA hsa-let-7b-3p ABI3BP 0.868207752019623 1.30460056774366e-05 -4.28101892502181 3.69754693029295e-18 miRNATAP -0.790568361416234 1.12132559665768e-10 NA NA NA hsa-miR-107 ABI3BP 1.30977326593435 1.30372468603965e-11 -4.28101892502181 3.69754693029295e-18 miRanda -1.14459602795567 2.79187455140958e-21 NA NA NA hsa-miR-181a-5p ABI3BP 2.29556023480783 1.8138457900616e-21 -4.28101892502181 3.69754693029295e-18 miRNATAP -0.735701772268394 1.42362548923125e-14 NA NA NA hsa-miR-181b-5p ABI3BP 2.49307679431293 3.92829250217627e-20 -4.28101892502181 3.69754693029295e-18 miRNATAP -0.735789780568069 2.67202376002673e-18 NA NA NA hsa-miR-181c-5p ABI3BP 1.58587920618301 1.57506918816933e-10 -4.28101892502181 3.69754693029295e-18 miRNATAP -0.530087528474455 5.24258697009724e-08 NA NA NA hsa-miR-32-3p ABI3BP 2.02436999565685 5.94091197945307e-09 -4.28101892502181 3.69754693029295e-18 mirMAP -0.589319329693262 3.91185523555954e-14 NA NA NA hsa-miR-32-5p ABI3BP 2.34056473219422 6.24134585974322e-20 -4.28101892502181 3.69754693029295e-18 miRNATAP -0.714478158770382 2.2911560690248e-15 NA NA NA hsa-miR-320a ABI3BP 0.438165828017084 0.0390159073347133 -4.28101892502181 3.69754693029295e-18 miRanda -0.646104687364728 2.95602195087477e-08 NA NA NA hsa-miR-320b ABI3BP 1.55692969039548 1.41071034251915e-08 -4.28101892502181 3.69754693029295e-18 miRanda -0.819290635014524 5.99781620325971e-22 NA NA NA hsa-miR-330-3p ABI3BP 0.876747334239085 0.00073709016089703 -4.28101892502181 3.69754693029295e-18 PITA -0.57648363752921 8.80882656882439e-10 NA NA NA hsa-miR-34c-5p ABI3BP 2.07190852984647 7.35776320806257e-08 -4.28101892502181 3.69754693029295e-18 miRanda -0.248915377138527 0.000236226957889448 NA NA NA hsa-miR-421 ABI3BP 1.17791565395543 6.78526676976629e-06 -4.28101892502181 3.69754693029295e-18 miRanda -0.630641345307337 9.64376112287943e-12 NA NA NA hsa-miR-455-5p ABI3BP 2.2582442061694 1.43472128037398e-13 -4.28101892502181 3.69754693029295e-18 miRanda -0.454181166096407 5.6809798933074e-09 NA NA NA hsa-miR-505-5p ABI3BP 1.89243395287645 9.82003586561819e-12 -4.28101892502181 3.69754693029295e-18 miRNATAP -0.647485879608852 2.78956975707006e-14 NA NA NA hsa-miR-576-5p ABI3BP 2.20467023993664 3.4053475193793e-19 -4.28101892502181 3.69754693029295e-18 PITA -0.950399132973645 3.3642994189831e-25 NA NA NA hsa-miR-590-3p ABI3BP 2.59289455139753 1.03200520972022e-21 -4.28101892502181 3.69754693029295e-18 miRanda -0.814291105023785 2.21408377144561e-21 NA NA NA hsa-miR-590-5p ABI3BP 3.18300989862077 2.06813568597893e-26 -4.28101892502181 3.69754693029295e-18 miRanda -0.841402399533267 3.42401795053116e-29 NA NA NA hsa-miR-92a-3p ABI3BP 2.06460102658973 1.44784291084757e-19 -4.28101892502181 3.69754693029295e-18 miRNATAP -1.23447648242855 4.75669537184414e-38 NA NA NA hsa-miR-92b-3p ABI3BP 1.20409245530001 3.41055816361655e-06 -4.28101892502181 3.69754693029295e-18 miRNATAP -0.385588826768552 4.78000590603929e-05 NA NA NA hsa-miR-484 ACTA2 1.81844463411787 1.82951571230938e-15 -3.49662779814752 2.35094195114616e-15 miRNAWalker2_validate -0.907423525236774 1.84016526461911e-24 NA NA NA hsa-miR-10b-3p ADAM12 0.77597971642517 0.00264877454133753 0.880573728493143 0.0562283395124088 mirMAP -0.547923759791827 1.07110585852272e-10 NA NA NA hsa-miR-129-5p ADAM12 -0.524170159980738 0.222582956006346 0.880573728493143 0.0562283395124088 miRanda;mirMAP -0.213437630937985 5.15515863241374e-05 NA NA NA hsa-miR-130b-3p ADAM12 3.5350292994509 1.73934183852569e-27 0.880573728493143 0.0562283395124088 miRNATAP -0.178801336213978 0.00541849263389738 NA NA NA hsa-miR-130b-5p ADAM12 2.9963110846538 1.98883029416455e-18 0.880573728493143 0.0562283395124088 mirMAP -0.236754753063851 0.000219850365156781 NA NA NA hsa-miR-148b-5p ADAM12 2.18024067300781 2.84770452413262e-14 0.880573728493143 0.0562283395124088 mirMAP -0.503020181470224 1.44698125504661e-10 NA NA NA hsa-miR-15b-3p ADAM12 2.33847028227712 4.29662877950836e-19 0.880573728493143 0.0562283395124088 mirMAP -0.371420941335471 4.8322262354629e-06 NA NA NA hsa-miR-186-5p ADAM12 1.47445398888668 3.0781726595413e-15 0.880573728493143 0.0562283395124088 mirMAP -0.49934770241035 1.6864342870584e-05 NA NA NA hsa-miR-19a-3p ADAM12 3.42309334186656 3.02671914353412e-28 0.880573728493143 0.0562283395124088 miRNATAP -0.247872588901785 0.000217352534391921 NA NA NA hsa-miR-19b-3p ADAM12 2.49529833021187 1.57028265846699e-23 0.880573728493143 0.0562283395124088 miRNATAP -0.430300108091765 3.07639626063328e-07 NA NA NA hsa-miR-20b-5p ADAM12 2.07706563022469 1.10107236083433e-05 0.880573728493143 0.0562283395124088 mirMAP -0.235283914366577 3.59541527184768e-07 NA NA NA hsa-miR-224-3p ADAM12 1.87536386559317 6.15140969394846e-05 0.880573728493143 0.0562283395124088 mirMAP -0.172955198718509 0.000463041213511992 NA NA NA hsa-miR-26b-5p ADAM12 0.885393662798425 3.2116297961629e-06 0.880573728493143 0.0562283395124088 mirMAP;miRNATAP -0.593587975438548 3.31998717235585e-07 NA NA NA hsa-miR-29b-3p ADAM12 1.65828197923813 1.02676780888141e-09 0.880573728493143 0.0562283395124088 miRNAWalker2_validate;miRTarBase;miRNATAP -0.297714239843424 0.000220109551376136 25886595 ADAM12 L is a direct target of the miR 29 and miR 200 families in breast cancer breast cancer hsa-miR-29c-3p ADAM12 -0.00968972577705429 0.97099586346872 0.880573728493143 0.0562283395124088 miRNATAP -0.540993052119639 5.59549748295171e-11 NA NA NA hsa-miR-301a-3p ADAM12 2.81024345929638 2.29784847962242e-17 0.880573728493143 0.0562283395124088 miRNATAP -0.389735560418446 7.6916842264634e-09 NA NA NA hsa-miR-320a ADAM12 0.438165828017084 0.0390159073347133 0.880573728493143 0.0562283395124088 mirMAP -0.665756798284788 1.52903599660502e-10 NA NA NA hsa-miR-320b ADAM12 1.55692969039548 1.41071034251915e-08 0.880573728493143 0.0562283395124088 mirMAP -0.42392629587754 8.86401108241749e-08 NA NA NA hsa-miR-33a-3p ADAM12 1.72765312072219 1.51784443453521e-07 0.880573728493143 0.0562283395124088 mirMAP -0.52607266832372 2.1571366198384e-13 NA NA NA hsa-miR-34a-3p ADAM12 1.75590866103657 8.02801510630657e-09 0.880573728493143 0.0562283395124088 mirMAP -0.371641777954077 3.06447898212028e-06 NA NA NA hsa-miR-3607-3p ADAM12 2.68532138541128 5.66716351955047e-14 0.880573728493143 0.0562283395124088 mirMAP;miRNATAP -0.314396984816609 3.31725676759149e-07 NA NA NA hsa-miR-361-5p ADAM12 0.971859117235239 5.30236555707088e-09 0.880573728493143 0.0562283395124088 miRanda -0.820527739820559 4.36749667275214e-10 NA NA NA hsa-miR-421 ADAM12 1.17791565395543 6.78526676976629e-06 0.880573728493143 0.0562283395124088 mirMAP;miRNATAP -0.273062405295576 0.00129520087117484 NA NA NA hsa-miR-429 ADAM12 4.48815175680773 2.44117492218206e-17 0.880573728493143 0.0562283395124088 miRanda;miRNATAP -0.295284180355858 5.50021366276346e-14 NA NA NA hsa-miR-454-3p ADAM12 2.47234127820054 1.12878018736016e-21 0.880573728493143 0.0562283395124088 miRNATAP -0.411144918218655 9.52329195741569e-07 NA NA NA hsa-miR-491-5p ADAM12 0.615770352820862 0.0418295628761654 0.880573728493143 0.0562283395124088 miRanda -0.240988337051605 0.002343327892957 NA NA NA hsa-miR-582-3p ADAM12 0.00876844181512659 0.977126166214707 0.880573728493143 0.0562283395124088 mirMAP -0.418559607416658 6.66253420241575e-09 NA NA NA hsa-miR-582-5p ADAM12 0.609226359812689 0.032988717891497 0.880573728493143 0.0562283395124088 miRNATAP -0.485502938390085 2.63297974680989e-10 NA NA NA hsa-miR-590-3p ADAM12 2.59289455139753 1.03200520972022e-21 0.880573728493143 0.0562283395124088 mirMAP -0.228608743638272 0.00464052809888151 NA NA NA hsa-miR-93-3p ADAM12 2.85383869771942 5.64481766902125e-23 0.880573728493143 0.0562283395124088 mirMAP -0.477575059218269 2.80554041274156e-11 NA NA NA hsa-miR-125a-5p ANPEP 0.599529391575274 0.0102300147180307 -0.910355136497126 0.0550970090453364 PITA;miRanda;miRNATAP -0.291606973982833 0.00316201933138207 NA NA NA hsa-miR-16-5p ANPEP 1.75824877145857 1.68592440033108e-16 -0.910355136497126 0.0550970090453364 miRNAWalker2_validate -0.290804730298211 0.00542410652264742 NA NA NA hsa-miR-423-5p ANPEP 0.963563145758616 9.86109015204915e-07 -0.910355136497126 0.0550970090453364 miRNATAP -0.746386613064604 6.2615617520413e-11 NA NA NA hsa-miR-96-5p ANPEP 4.89433085814374 1.92000659886961e-31 -0.910355136497126 0.0550970090453364 mirMAP -0.315891010184849 6.68822898377284e-10 NA NA NA hsa-miR-429 AREG 4.48815175680773 2.44117492218206e-17 -1.82108928709305 0.00454782507843903 miRanda -0.192425822189951 0.000625024329953195 NA NA NA hsa-miR-200b-3p BASP1 3.78235093249346 3.18343003239465e-14 -0.115765471779633 0.797246530625034 TargetScan -0.184415877611778 1.10323548254093e-05 NA NA NA hsa-miR-200c-3p BASP1 3.50132673580082 2.42716349086937e-15 -0.115765471779633 0.797246530625034 miRNATAP -0.189407017412651 6.11095304259437e-05 NA NA NA hsa-miR-429 BASP1 4.48815175680773 2.44117492218206e-17 -0.115765471779633 0.797246530625034 PITA;miRanda;miRNATAP -0.144264579590549 0.000238273678119739 NA NA NA hsa-let-7b-3p BDNF 0.868207752019623 1.30460056774366e-05 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.285067683917082 0.00912745906089909 NA NA NA hsa-miR-103a-3p BDNF 1.44083190496858 1.53799939616416e-13 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.513010583082046 2.18583657796716e-06 NA NA NA hsa-miR-107 BDNF 1.30977326593435 1.30372468603965e-11 -2.90846311399482 3.32327619207597e-11 MirTarget;PITA;miRanda;miRNATAP -0.301411719956826 0.00652496504590489 27498977 MicroRNA 107 inhibits tumor growth and metastasis by targeting the BDNF mediated PI3K/AKT pathway in human non small lung cancer; In addition BDNF expression was upregulated and inversely correlated with miR-107 in NSCLC tissues; Enforced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-107 on NSCLC proliferation migration and invasion; miR-107 overexpression or downregulation of BDNF was able to inhibit activation of PI3K/AKT signaling pathway; Taken together our findings present the first evidence that miR-107 could suppress NSCLC metastasis by targeting BDNF and indirectly regulating PI3K/AKT signaling pathway which might lead to a potential therapeutic strategy focusing on miR-107 and BDNF for human NSCLC metastasis lung cancer hsa-miR-10a-5p BDNF 1.15016989191194 0.00372037233992369 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.239868149823933 9.76923403527126e-06 NA NA NA hsa-miR-15a-5p BDNF 2.34669284378787 1.69544424500258e-23 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.538797123359211 4.53591149420254e-10 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC liver cancer hsa-miR-15b-5p BDNF 1.57112623124278 9.14247846750597e-13 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.337417459977062 0.000476250471995874 NA NA NA hsa-miR-16-5p BDNF 1.75824877145857 1.68592440033108e-16 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.404475155904508 3.95284638464173e-05 NA NA NA hsa-miR-182-5p BDNF 3.53923166221814 5.07781258121574e-21 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.304142174368882 2.036484274037e-08 NA NA NA hsa-miR-191-5p BDNF 2.30038190670664 9.93191704545938e-17 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.485298765179322 6.26143603678241e-11 NA NA NA hsa-miR-210-3p BDNF 6.07079758655679 2.22120227133377e-28 -2.90846311399482 3.32327619207597e-11 miRNAWalker2_validate;miRTarBase -0.237223359082858 5.07246234320821e-11 NA NA NA hsa-miR-22-3p BDNF 1.21545661147757 1.61670170137775e-13 -2.90846311399482 3.32327619207597e-11 miRNAWalker2_validate;miRTarBase -0.538030930409075 3.25374878143957e-05 NA NA NA hsa-miR-26b-3p BDNF 2.18464160365372 2.11543189388328e-18 -2.90846311399482 3.32327619207597e-11 MirTarget -0.444310109951697 8.07362790493106e-08 NA NA NA hsa-miR-29b-2-5p BDNF 0.910668640983475 0.00666655585493488 -2.90846311399482 3.32327619207597e-11 mirMAP -0.385323162445974 1.40825527826931e-09 NA NA NA hsa-miR-3065-3p BDNF 2.16221780121195 9.65525739884541e-09 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.207023369564498 0.000246555472230515 NA NA NA hsa-miR-3065-5p BDNF 2.74629919868982 1.86846589298284e-08 -2.90846311399482 3.32327619207597e-11 mirMAP;miRNATAP -0.168376118012365 0.00167095455996276 NA NA NA hsa-miR-30c-5p BDNF 0.778774633108 0.000285599212429136 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.452622492319709 7.0923627825397e-06 NA NA NA hsa-miR-30d-5p BDNF 0.675423997639582 0.00270618816039773 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.31555337460895 0.00110619099852774 NA NA NA hsa-miR-30e-5p BDNF 1.23904909539663 1.35561917122157e-09 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.710933428108993 4.68409714514429e-12 NA NA NA hsa-miR-330-3p BDNF 0.876747334239085 0.00073709016089703 -2.90846311399482 3.32327619207597e-11 MirTarget -0.350307363358734 2.52309207840318e-05 NA NA NA hsa-miR-339-5p BDNF 2.68710938429893 3.03134080808154e-16 -2.90846311399482 3.32327619207597e-11 miRanda -0.208909558420091 0.0010320906387239 NA NA NA hsa-miR-33a-3p BDNF 1.72765312072219 1.51784443453521e-07 -2.90846311399482 3.32327619207597e-11 mirMAP -0.189569900102124 0.00822808887496796 NA NA NA hsa-miR-361-5p BDNF 0.971859117235239 5.30236555707088e-09 -2.90846311399482 3.32327619207597e-11 PITA;miRanda;miRNATAP -0.549614574828476 2.2273701996563e-05 NA NA NA hsa-miR-3913-5p BDNF 2.44353493655328 8.95279496632448e-15 -2.90846311399482 3.32327619207597e-11 mirMAP -0.401161818585588 3.16401389217705e-09 NA NA NA hsa-miR-452-3p BDNF 2.42521958420768 4.08754552781156e-07 -2.90846311399482 3.32327619207597e-11 MirTarget -0.15349375691044 0.000617556235812272 NA NA NA hsa-miR-452-5p BDNF 1.37180058737183 0.00171494843537772 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.159672549433471 0.00121343995890147 NA NA NA hsa-miR-589-3p BDNF 2.51971841868825 2.39125940264107e-11 -2.90846311399482 3.32327619207597e-11 MirTarget -0.19485326256731 0.00234458194019574 NA NA NA hsa-miR-590-3p BDNF 2.59289455139753 1.03200520972022e-21 -2.90846311399482 3.32327619207597e-11 miRanda;mirMAP;miRNATAP -0.215106825481362 0.00623574226190281 NA NA NA hsa-miR-944 BDNF 2.91186649218281 1.31574753528144e-06 -2.90846311399482 3.32327619207597e-11 PITA;mirMAP;miRNATAP -0.210249837446185 6.49747993753151e-09 NA NA NA hsa-miR-30b-3p BGN 0.834142820354026 0.000972582820878813 0.606941335048649 0.112008541607815 mirMAP -0.502217353235535 2.42119967008206e-12 NA NA NA hsa-miR-330-5p BGN 1.15100069700871 4.85551805046014e-07 0.606941335048649 0.112008541607815 miRanda -0.372579658065314 2.85225532423328e-06 NA NA NA hsa-miR-486-5p BGN -0.194913133034028 0.607377798807705 0.606941335048649 0.112008541607815 miRanda -0.253322501136108 1.47027603145989e-07 NA NA NA hsa-miR-1226-3p BMP1 1.38118928579963 0.000205503474787488 0.194918683355282 0.453370270266782 mirMAP -0.232149237403934 7.33615926531401e-10 NA NA NA hsa-miR-148b-5p BMP1 2.18024067300781 2.84770452413262e-14 0.194918683355282 0.453370270266782 mirMAP -0.198685964605232 8.63003693685366e-06 NA NA NA hsa-miR-29c-3p BMP1 -0.00968972577705429 0.97099586346872 0.194918683355282 0.453370270266782 miRNATAP -0.396699137116425 2.90747356867207e-18 NA NA NA hsa-miR-30b-3p BMP1 0.834142820354026 0.000972582820878813 0.194918683355282 0.453370270266782 miRNATAP -0.325331882464193 2.67602969575588e-11 NA NA NA hsa-miR-335-5p BMP1 1.77247705492746 2.22457658872091e-06 0.194918683355282 0.453370270266782 miRNAWalker2_validate -0.106100503717493 0.00133590176167671 NA NA NA hsa-miR-34a-5p BMP1 1.9016323452565 1.43092834643601e-14 0.194918683355282 0.453370270266782 mirMAP -0.153976655186265 0.00180202470782668 NA NA NA hsa-miR-429 BMP1 4.48815175680773 2.44117492218206e-17 0.194918683355282 0.453370270266782 miRNATAP -0.193320223930749 7.26954110070322e-19 NA NA NA hsa-miR-484 BMP1 1.81844463411787 1.82951571230938e-15 0.194918683355282 0.453370270266782 miRNATAP -0.16472814720616 0.00199393408962168 NA NA NA hsa-miR-491-5p BMP1 0.615770352820862 0.0418295628761654 0.194918683355282 0.453370270266782 PITA;miRanda -0.150558597829735 0.000708126384132199 NA NA NA hsa-miR-671-3p BMP1 2.20199226665068 7.0886613366934e-16 0.194918683355282 0.453370270266782 miRNATAP -0.214928534456121 1.12319868010139e-06 NA NA NA hsa-miR-141-3p CADM1 5.02396127982626 2.19224509139725e-24 -1.1928516537365 0.0125125326037739 MirTarget;TargetScan -0.158377342012299 0.000330308063762073 NA NA NA hsa-miR-15a-5p CADM1 2.34669284378787 1.69544424500258e-23 -1.1928516537365 0.0125125326037739 miRNAWalker2_validate;miRTarBase;miRNATAP -0.26989087540155 0.00398839838276791 NA NA NA hsa-miR-15b-5p CADM1 1.57112623124278 9.14247846750597e-13 -1.1928516537365 0.0125125326037739 miRNATAP -0.39110303102368 0.000141050953502164 NA NA NA hsa-miR-16-5p CADM1 1.75824877145857 1.68592440033108e-16 -1.1928516537365 0.0125125326037739 miRNAWalker2_validate;miRTarBase;miRNATAP -0.379900904546319 0.000299782922936846 NA NA NA hsa-miR-193b-3p CADM1 2.25711804611899 4.1940744806631e-14 -1.1928516537365 0.0125125326037739 MirTarget -0.342549961840329 4.51206402611801e-06 NA NA NA hsa-miR-1976 CADM1 2.06550563678192 7.81396978619772e-18 -1.1928516537365 0.0125125326037739 MirTarget -0.358077803349068 0.000111734211602837 NA NA NA hsa-miR-205-5p CADM1 4.1389800495524 2.05488295686453e-12 -1.1928516537365 0.0125125326037739 MirTarget;miRNATAP -0.171132926241332 6.35431108274554e-06 NA NA NA hsa-miR-224-3p CADM1 1.87536386559317 6.15140969394846e-05 -1.1928516537365 0.0125125326037739 MirTarget -0.19539930850694 0.000134095156040363 NA NA NA hsa-miR-23a-3p CADM1 1.00493340843378 2.55313889288924e-08 -1.1928516537365 0.0125125326037739 miRNATAP -0.525643861959079 3.64143357626576e-05 NA NA NA hsa-miR-27a-3p CADM1 1.66542180327138 4.93775737894805e-13 -1.1928516537365 0.0125125326037739 MirTarget;miRNATAP -0.426100234284301 1.27732249612025e-05 NA NA NA hsa-miR-34c-5p CADM1 2.07190852984647 7.35776320806257e-08 -1.1928516537365 0.0125125326037739 miRanda -0.164309116357194 0.00942322739804164 NA NA NA hsa-miR-590-3p CADM1 2.59289455139753 1.03200520972022e-21 -1.1928516537365 0.0125125326037739 miRanda;mirMAP -0.237078665183319 0.00464845719636363 NA NA NA hsa-miR-590-5p CADM1 3.18300989862077 2.06813568597893e-26 -1.1928516537365 0.0125125326037739 PITA;miRanda;miRNATAP -0.230902021979219 0.00199392890239026 NA NA NA hsa-miR-92a-3p CADM1 2.06460102658973 1.44784291084757e-19 -1.1928516537365 0.0125125326037739 miRNATAP -0.412037991230878 2.16334411583674e-05 NA NA NA hsa-let-7a-5p CALD1 0.618599506841644 2.76973453058748e-05 -2.4663455628847 1.26294093745705e-11 miRNATAP -1.03792793649825 3.49951826389475e-18 NA NA NA hsa-let-7b-5p CALD1 0.604314269683977 0.00140009936153214 -2.4663455628847 1.26294093745705e-11 miRNATAP -0.562142582687856 2.95462714837688e-09 NA NA NA hsa-let-7e-5p CALD1 0.860104282510173 6.04758298373779e-05 -2.4663455628847 1.26294093745705e-11 miRNATAP -0.447557457272937 7.67058170095187e-08 NA NA NA hsa-let-7f-5p CALD1 0.495648727272215 0.00355972741198794 -2.4663455628847 1.26294093745705e-11 miRNATAP -0.682946945309958 9.59313295051782e-11 NA NA NA hsa-let-7g-5p CALD1 1.20061455355116 1.50237505511483e-12 -2.4663455628847 1.26294093745705e-11 miRNATAP -1.32154302588691 2.11021167452452e-44 NA NA NA hsa-miR-106a-5p CALD1 2.48882002962836 1.99757727374521e-12 -2.4663455628847 1.26294093745705e-11 miRNATAP -0.494466940496305 4.44678639786279e-26 NA NA NA hsa-miR-106b-5p CALD1 2.46782146831112 1.36171495805632e-23 -2.4663455628847 1.26294093745705e-11 miRNATAP -0.919349515854379 2.86793295461606e-50 NA NA NA hsa-miR-107 CALD1 1.30977326593435 1.30372468603965e-11 -2.4663455628847 1.26294093745705e-11 miRanda -0.913667405474914 5.90743754560381e-26 NA NA NA hsa-miR-10b-3p CALD1 0.77597971642517 0.00264877454133753 -2.4663455628847 1.26294093745705e-11 miRNATAP -0.671246914954333 4.29653137940368e-24 NA NA NA hsa-miR-125a-3p CALD1 1.24490295132072 5.26925231010328e-06 -2.4663455628847 1.26294093745705e-11 miRanda -0.207763359733429 0.00154474089528059 NA NA NA hsa-miR-126-5p CALD1 0.895338176458417 2.33372756450713e-05 -2.4663455628847 1.26294093745705e-11 mirMAP -0.531106669082742 2.27473597857979e-10 NA NA NA hsa-miR-129-5p CALD1 -0.524170159980738 0.222582956006346 -2.4663455628847 1.26294093745705e-11 miRanda -0.160403676182862 0.000173151596845038 NA NA NA hsa-miR-149-5p CALD1 2.94200492826326 4.93436498919036e-14 -2.4663455628847 1.26294093745705e-11 miRNAWalker2_validate -0.38560902679619 2.76974678901036e-19 NA NA NA hsa-miR-15a-5p CALD1 2.34669284378787 1.69544424500258e-23 -2.4663455628847 1.26294093745705e-11 miRNAWalker2_validate -0.848396976933768 1.00350791777091e-36 NA NA NA hsa-miR-16-2-3p CALD1 2.31623086727196 4.29838149388188e-20 -2.4663455628847 1.26294093745705e-11 mirMAP -0.722170460534748 1.7559847167554e-29 NA NA NA hsa-miR-17-5p CALD1 3.2710598467455 9.93128340539455e-27 -2.4663455628847 1.26294093745705e-11 TargetScan;miRNATAP -0.650953013442474 1.21720820803598e-37 NA NA NA hsa-miR-182-5p CALD1 3.53923166221814 5.07781258121574e-21 -2.4663455628847 1.26294093745705e-11 MirTarget -0.572370021752522 4.34620815049957e-44 NA NA NA hsa-miR-196b-5p CALD1 1.71646270856386 4.37735885910369e-09 -2.4663455628847 1.26294093745705e-11 MirTarget -0.495738017640164 2.59127734390852e-17 NA NA NA hsa-miR-197-3p CALD1 1.75733174019505 8.88576793100499e-13 -2.4663455628847 1.26294093745705e-11 MirTarget -0.635286942324431 2.09681742089142e-20 NA NA NA hsa-miR-20a-5p CALD1 3.15577933619191 4.19753346442454e-25 -2.4663455628847 1.26294093745705e-11 miRNATAP -0.658687784571499 4.20409767342805e-38 NA NA NA hsa-miR-20b-5p CALD1 2.07706563022469 1.10107236083433e-05 -2.4663455628847 1.26294093745705e-11 miRNATAP -0.337085771787929 9.8673795992371e-21 NA NA NA hsa-miR-24-2-5p CALD1 2.07171035460647 3.15853539996136e-16 -2.4663455628847 1.26294093745705e-11 MirTarget -0.225087951698115 0.00107372398096041 NA NA NA hsa-miR-3065-5p CALD1 2.74629919868982 1.86846589298284e-08 -2.4663455628847 1.26294093745705e-11 mirMAP -0.240806855620266 4.40939639596234e-08 NA NA NA hsa-miR-32-3p CALD1 2.02436999565685 5.94091197945307e-09 -2.4663455628847 1.26294093745705e-11 MirTarget -0.52715396940788 2.21587663205599e-21 NA NA NA hsa-miR-320a CALD1 0.438165828017084 0.0390159073347133 -2.4663455628847 1.26294093745705e-11 PITA;miRanda;miRNATAP -0.745521035419264 1.1287825911874e-19 NA NA NA hsa-miR-320b CALD1 1.55692969039548 1.41071034251915e-08 -2.4663455628847 1.26294093745705e-11 PITA;miRanda;miRNATAP -0.60167725569511 1.84317266103756e-22 NA NA NA hsa-miR-34a-5p CALD1 1.9016323452565 1.43092834643601e-14 -2.4663455628847 1.26294093745705e-11 miRNAWalker2_validate -0.73446754089701 2.61417639108455e-28 NA NA NA hsa-miR-361-5p CALD1 0.971859117235239 5.30236555707088e-09 -2.4663455628847 1.26294093745705e-11 miRanda;miRNATAP -1.20827063897453 1.48566150573849e-33 NA NA NA hsa-miR-374a-3p CALD1 0.533309330504947 0.00192918429705142 -2.4663455628847 1.26294093745705e-11 miRNATAP -0.51941641165839 8.0554969666498e-07 NA NA NA hsa-miR-374a-5p CALD1 0.484615721953736 0.0042981729815149 -2.4663455628847 1.26294093745705e-11 mirMAP -0.476576765763675 8.62340218818856e-06 NA NA NA hsa-miR-421 CALD1 1.17791565395543 6.78526676976629e-06 -2.4663455628847 1.26294093745705e-11 miRanda -0.391683057325632 7.41885181370218e-09 NA NA NA hsa-miR-429 CALD1 4.48815175680773 2.44117492218206e-17 -2.4663455628847 1.26294093745705e-11 miRanda -0.4251755083316 2.2331642070939e-48 NA NA NA hsa-miR-455-5p CALD1 2.2582442061694 1.43472128037398e-13 -2.4663455628847 1.26294093745705e-11 miRanda -0.150562085879115 0.0088678691956091 NA NA NA hsa-miR-484 CALD1 1.81844463411787 1.82951571230938e-15 -2.4663455628847 1.26294093745705e-11 PITA -0.769947120321809 1.55277630089714e-26 NA NA NA hsa-miR-491-5p CALD1 0.615770352820862 0.0418295628761654 -2.4663455628847 1.26294093745705e-11 miRanda -0.355670927671817 1.86587995660318e-08 NA NA NA hsa-miR-501-3p CALD1 1.83132758513743 1.10971547702065e-10 -2.4663455628847 1.26294093745705e-11 TargetScan;miRNATAP -0.515614658682675 8.88320062568862e-18 NA NA NA hsa-miR-590-3p CALD1 2.59289455139753 1.03200520972022e-21 -2.4663455628847 1.26294093745705e-11 miRanda;mirMAP -0.598299799300485 6.70214704495481e-22 NA NA NA hsa-miR-590-5p CALD1 3.18300989862077 2.06813568597893e-26 -2.4663455628847 1.26294093745705e-11 miRanda -0.622930885627448 1.86781811680692e-30 NA NA NA hsa-miR-93-5p CALD1 3.03961860136032 1.11672209617395e-24 -2.4663455628847 1.26294093745705e-11 miRNATAP -0.775726801709472 6.66173877031081e-53 NA NA NA hsa-let-7a-5p CALU 0.618599506841644 2.76973453058748e-05 -0.148100201074846 0.463184247628706 TargetScan -0.393014570045837 2.41255035877826e-09 NA NA NA hsa-miR-103a-3p CALU 1.44083190496858 1.53799939616416e-13 -0.148100201074846 0.463184247628706 miRNAWalker2_validate;MirTarget -0.4221778569347 2.24064147491594e-19 NA NA NA hsa-miR-107 CALU 1.30977326593435 1.30372468603965e-11 -0.148100201074846 0.463184247628706 MirTarget;PITA;miRanda -0.255574232529774 1.89693589378858e-07 NA NA NA hsa-miR-126-5p CALU 0.895338176458417 2.33372756450713e-05 -0.148100201074846 0.463184247628706 MirTarget -0.14205368090278 0.00199804445592384 NA NA NA hsa-miR-141-3p CALU 5.02396127982626 2.19224509139725e-24 -0.148100201074846 0.463184247628706 TargetScan -0.195681214306377 1.90065013398411e-29 NA NA NA hsa-miR-15a-5p CALU 2.34669284378787 1.69544424500258e-23 -0.148100201074846 0.463184247628706 MirTarget -0.301042152389773 3.22333117515418e-15 NA NA NA hsa-miR-15b-5p CALU 1.57112623124278 9.14247846750597e-13 -0.148100201074846 0.463184247628706 MirTarget -0.221546310341534 2.40650590715217e-07 NA NA NA hsa-miR-16-1-3p CALU 2.56983217111073 3.02262181237943e-20 -0.148100201074846 0.463184247628706 mirMAP -0.254534630436095 2.24887565971111e-14 NA NA NA hsa-miR-16-5p CALU 1.75824877145857 1.68592440033108e-16 -0.148100201074846 0.463184247628706 miRNAWalker2_validate;MirTarget -0.242531412669303 2.90831904762124e-08 NA NA NA hsa-miR-181c-5p CALU 1.58587920618301 1.57506918816933e-10 -0.148100201074846 0.463184247628706 mirMAP -0.192374336414271 4.83100777465388e-07 NA NA NA hsa-miR-186-5p CALU 1.47445398888668 3.0781726595413e-15 -0.148100201074846 0.463184247628706 MirTarget -0.232180875906431 4.34194218243082e-06 NA NA NA hsa-miR-200b-3p CALU 3.78235093249346 3.18343003239465e-14 -0.148100201074846 0.463184247628706 MirTarget;TargetScan -0.207957440264492 1.42283216429881e-32 NA NA NA hsa-miR-200c-3p CALU 3.50132673580082 2.42716349086937e-15 -0.148100201074846 0.463184247628706 MirTarget -0.230686970082118 1.2951659506794e-31 NA NA NA hsa-miR-205-5p CALU 4.1389800495524 2.05488295686453e-12 -0.148100201074846 0.463184247628706 MirTarget -0.106608945066527 1.12394083157766e-11 NA NA NA hsa-miR-2110 CALU 1.16625590651194 6.4784195289885e-05 -0.148100201074846 0.463184247628706 MirTarget -0.197282528899895 2.06010015348679e-08 NA NA NA hsa-miR-23b-3p CALU -0.251132426825047 0.150200321210792 -0.148100201074846 0.463184247628706 mirMAP -0.161783380766852 0.00430913631368004 NA NA NA hsa-miR-29b-3p CALU 1.65828197923813 1.02676780888141e-09 -0.148100201074846 0.463184247628706 miRNAWalker2_validate;MirTarget -0.165824029398312 2.1031416445192e-06 NA NA NA hsa-miR-29c-3p CALU -0.00968972577705429 0.97099586346872 -0.148100201074846 0.463184247628706 MirTarget -0.341594336692818 1.34442379914776e-22 NA NA NA hsa-miR-30b-5p CALU 0.800822374912712 0.000133601914525413 -0.148100201074846 0.463184247628706 MirTarget -0.296764098661707 7.75133816887029e-11 NA NA NA hsa-miR-30c-5p CALU 0.778774633108 0.000285599212429136 -0.148100201074846 0.463184247628706 MirTarget -0.378046555839891 5.44430620043803e-18 NA NA NA hsa-miR-30d-3p CALU 0.977747550180601 4.3048212205381e-05 -0.148100201074846 0.463184247628706 MirTarget -0.311105589854982 3.0004045226336e-15 NA NA NA hsa-miR-30d-5p CALU 0.675423997639582 0.00270618816039773 -0.148100201074846 0.463184247628706 MirTarget -0.380743793200721 4.71730479422658e-20 NA NA NA hsa-miR-30e-3p CALU -0.215663037684509 0.235375122783546 -0.148100201074846 0.463184247628706 MirTarget;mirMAP -0.408433813466279 9.61669596450444e-15 NA NA NA hsa-miR-30e-5p CALU 1.23904909539663 1.35561917122157e-09 -0.148100201074846 0.463184247628706 MirTarget -0.468148916296015 5.56286690007613e-26 NA NA NA hsa-miR-32-3p CALU 2.02436999565685 5.94091197945307e-09 -0.148100201074846 0.463184247628706 mirMAP -0.153862973848169 7.45841594430647e-07 NA NA NA hsa-miR-320a CALU 0.438165828017084 0.0390159073347133 -0.148100201074846 0.463184247628706 miRNAWalker2_validate -0.392174566993726 9.99141446335398e-19 NA NA NA hsa-miR-33a-3p CALU 1.72765312072219 1.51784443453521e-07 -0.148100201074846 0.463184247628706 mirMAP -0.196912771083922 4.26365655573468e-10 NA NA NA hsa-miR-3607-3p CALU 2.68532138541128 5.66716351955047e-14 -0.148100201074846 0.463184247628706 MirTarget -0.151026412029754 1.68822345071098e-08 NA NA NA hsa-miR-374a-5p CALU 0.484615721953736 0.0042981729815149 -0.148100201074846 0.463184247628706 mirMAP -0.149949219816537 0.009968641743226 NA NA NA hsa-miR-429 CALU 4.48815175680773 2.44117492218206e-17 -0.148100201074846 0.463184247628706 MirTarget;PITA;miRanda -0.180103969723333 1.18579558920899e-27 NA NA NA hsa-miR-590-3p CALU 2.59289455139753 1.03200520972022e-21 -0.148100201074846 0.463184247628706 MirTarget;miRanda;mirMAP -0.11016300669877 0.00174050824996201 NA NA NA hsa-miR-7-1-3p CALU 1.84950311431067 1.25300363397654e-13 -0.148100201074846 0.463184247628706 mirMAP -0.133767358250262 0.00042211960295999 NA NA NA hsa-miR-940 CALU 3.21011374578759 2.7923171128495e-14 -0.148100201074846 0.463184247628706 MirTarget -0.111085345270904 4.45588477820701e-06 NA NA NA hsa-miR-944 CALU 2.91186649218281 1.31574753528144e-06 -0.148100201074846 0.463184247628706 PITA;mirMAP -0.124021409437892 8.41650900166206e-15 NA NA NA hsa-miR-107 CAP2 1.30977326593435 1.30372468603965e-11 -2.18974053536335 2.06679033597497e-09 miRanda -0.511660545683888 1.60119773328596e-08 NA NA NA hsa-miR-320a CAP2 0.438165828017084 0.0390159073347133 -2.18974053536335 2.06679033597497e-09 miRanda -0.371804111743538 1.2253981634658e-05 NA NA NA hsa-miR-320b CAP2 1.55692969039548 1.41071034251915e-08 -2.18974053536335 2.06679033597497e-09 miRanda -0.330226502816567 2.53331302030404e-07 NA NA NA hsa-miR-335-3p CAP2 3.08791651139852 5.31309869723517e-12 -2.18974053536335 2.06679033597497e-09 mirMAP -0.223367186259626 7.05941217680843e-09 NA NA NA hsa-miR-429 CAP2 4.48815175680773 2.44117492218206e-17 -2.18974053536335 2.06679033597497e-09 miRanda -0.315209196733483 1.59228894497917e-24 NA NA NA hsa-miR-491-5p CAP2 0.615770352820862 0.0418295628761654 -2.18974053536335 2.06679033597497e-09 miRanda -0.230372745889772 0.000304378771067258 NA NA NA hsa-miR-582-5p CAP2 0.609226359812689 0.032988717891497 -2.18974053536335 2.06679033597497e-09 PITA;miRNATAP -0.298446125649814 1.90133921264359e-06 NA NA NA hsa-miR-590-3p CAP2 2.59289455139753 1.03200520972022e-21 -2.18974053536335 2.06679033597497e-09 PITA;miRanda;mirMAP -0.372091973747258 6.84463024730159e-09 NA NA NA hsa-miR-148a-5p CD44 1.16173838132242 0.000148929299881612 -0.796526651909205 0.0427559627960533 mirMAP -0.184693372477928 0.00280500362000093 23861222 In MHCC97H and MHCC97L cells over-expression of miR-148a blocked the EMT process attenuated the expression of CD90 and CD44 biomarkers for liver cancer stem cells and inhibited their migratory capacity liver cancer hsa-miR-15b-5p CD44 1.57112623124278 9.14247846750597e-13 -0.796526651909205 0.0427559627960533 miRNAWalker2_validate -0.447526802339096 9.12256284724987e-08 NA NA NA hsa-miR-16-5p CD44 1.75824877145857 1.68592440033108e-16 -0.796526651909205 0.0427559627960533 miRNAWalker2_validate -0.230625961296894 0.00778893359877255 NA NA NA hsa-miR-181a-2-3p CD44 2.19062681262366 3.81790102612782e-13 -0.796526651909205 0.0427559627960533 MirTarget -0.228096134984064 0.000193690082473942 NA NA NA hsa-miR-185-5p CD44 2.34016206907488 1.17481626642022e-26 -0.796526651909205 0.0427559627960533 MirTarget -0.365105727396741 7.52346556220384e-06 NA NA NA hsa-miR-28-5p CD44 0.230152919654905 0.0742909586754846 -0.796526651909205 0.0427559627960533 miRanda -0.917439364317955 9.13749604227941e-10 NA NA NA hsa-miR-30e-3p CD44 -0.215663037684509 0.235375122783546 -0.796526651909205 0.0427559627960533 mirMAP -0.790970349895941 1.75570512558694e-14 NA NA NA hsa-miR-320a CD44 0.438165828017084 0.0390159073347133 -0.796526651909205 0.0427559627960533 miRNAWalker2_validate -0.270789976894063 0.00271905181476129 NA NA NA hsa-miR-326 CD44 0.715313016136042 0.0610265683213359 -0.796526651909205 0.0427559627960533 miRanda -0.347899847622553 1.02699780402226e-12 NA NA NA hsa-miR-328-3p CD44 0.596804159297544 0.013858523511843 -0.796526651909205 0.0427559627960533 miRNAWalker2_validate;miRTarBase -0.386675085611228 7.19138603194367e-07 NA NA NA hsa-miR-330-3p CD44 0.876747334239085 0.00073709016089703 -0.796526651909205 0.0427559627960533 miRNAWalker2_validate;miRTarBase -0.400115502634685 3.07400539078329e-08 NA NA NA hsa-miR-330-5p CD44 1.15100069700871 4.85551805046014e-07 -0.796526651909205 0.0427559627960533 miRanda -0.234747247689746 0.00452352423556939 NA NA NA hsa-miR-33a-3p CD44 1.72765312072219 1.51784443453521e-07 -0.796526651909205 0.0427559627960533 mirMAP -0.385531577314183 3.97985384939592e-10 NA NA NA hsa-miR-34a-5p CD44 1.9016323452565 1.43092834643601e-14 -0.796526651909205 0.0427559627960533 miRNAWalker2_validate;miRTarBase -0.275230949000913 0.000227008858457591 25572695;24423412;25551284;25044638;21240262;26231042;27497057;23314380 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;Furthermore we identified CD44 as being targeted by miR-34a in MIBC cells following cisplatin treatment and increased CD44 expression could efficiently reverse the effect of miR-34a on MIBC cell proliferation colongenic potential and chemosensitivity; Cisplatin-based chemotherapy induced demethylation of miR-34a promoter and increased miR-34a expression which in turn sensitized MIBC cells to cisplatin and decreased the tumorigenicity and proliferation of cancer cells that by reducing the production of CD44;MicroRNA 34a functions as an anti metastatic microRNA and suppresses angiogenesis in bladder cancer by directly targeting CD44; In this study we focus on it that microRNA-34a functions as an anti-metastatic microRNA and suppress angiogenesis in bladder cancer by directly targeting CD44; Our study defines a major metastasis and angiogenesis suppressive role for mir-34a a microRNA functions as a tumor suppressor in bladder cancer by directly targeting CD44 which would be helpful as a therapeutic approach to block bladder cancer metastasis;Nanocomplex-assisted delivery of miR-34a induces cell apoptosis and suppresses migration proliferation and tumor growth of breast cancer cells via targeting CD44 and a Notch-1-signaling pathway;The microRNA miR 34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44; We identified and validated CD44 as a direct and functional target of miR-34a and found that CD44 knockdown phenocopied miR-34a overexpression in inhibiting prostate cancer regeneration and metastasis;Registered report: the microRNA miR 34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44; Tumors with exogenous miR-34a showed reduced levels of CD44 expression Figure 4A and mutation of two putative miR-34a binding sites in the CD33 3' UTR partially abrogated signal repression in a luciferase assay Figure 4D;Nanovesicle mediated systemic delivery of microRNA 34a for CD44 overexpressing gastric cancer stem cell therapy; MicroRNA-34a miR-34a is a promising candidate for CD44 repression-based cancer therapy as it has been reported to inhibit proliferation metastasis and survival of CD44-positive CSCs; Here we used nanovesicles containing PLI/miR complexes NVs/miR to systemically deliver miR-34a and induce miR-34a-triggered CD44 suppression in orthotopically and subcutaneously implanted tumors in nude mice;miR 34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44; The ectopic overexpression of miR-34a significantly inhibited the migration and invasive ability of osteosarcoma cells by repressing the expression of CD44; These data suggest that miR-34a plays a tumor suppressor role in the metastasis of osteosarcoma cells by repressing the expression of CD44; Therefore it can be concluded that through the inhibition of CD44 expression levels miR-34a plays a significant role in the migration and invasion of osteosarcoma cells ;;metastasis;;metastasis;metastasis;metastasis;poor survival;metastasis bladder cancer;bladder cancer;bladder cancer;breast cancer;prostate cancer;prostate cancer;gastric cancer;sarcoma hsa-miR-421 CD44 1.17791565395543 6.78526676976629e-06 -0.796526651909205 0.0427559627960533 miRanda -0.368683289724633 2.69362557967671e-07 NA NA NA hsa-miR-532-3p CD44 1.96631878320218 4.53421954361695e-13 -0.796526651909205 0.0427559627960533 miRNATAP -0.442544677928769 3.69356749912527e-11 NA NA NA hsa-miR-744-5p CD44 1.48254348878737 3.23019501613577e-09 -0.796526651909205 0.0427559627960533 miRNAWalker2_validate -0.463511714400314 2.9614674442169e-10 NA NA NA hsa-let-7a-5p CD59 0.618599506841644 2.76973453058748e-05 -0.701153559236412 0.00130409241528683 MirTarget -0.199754946687504 0.00605521970626074 NA NA NA hsa-let-7d-5p CD59 1.33236798905207 1.1741085658466e-13 -0.701153559236412 0.00130409241528683 MirTarget -0.224140068842737 0.00010261477671492 NA NA NA hsa-let-7f-5p CD59 0.495648727272215 0.00355972741198794 -0.701153559236412 0.00130409241528683 MirTarget -0.246239255037001 8.77145436253729e-05 NA NA NA hsa-let-7g-5p CD59 1.20061455355116 1.50237505511483e-12 -0.701153559236412 0.00130409241528683 MirTarget -0.314530007549318 2.46671695169767e-07 NA NA NA hsa-miR-141-3p CD59 5.02396127982626 2.19224509139725e-24 -0.701153559236412 0.00130409241528683 mirMAP -0.104731717796861 1.60748972337276e-07 NA NA NA hsa-miR-182-5p CD59 3.53923166221814 5.07781258121574e-21 -0.701153559236412 0.00130409241528683 MirTarget -0.144218246334533 4.83638010283245e-08 NA NA NA hsa-miR-200a-3p CD59 4.59434485520731 6.38952518573476e-18 -0.701153559236412 0.00130409241528683 mirMAP -0.135679943959474 2.36408069319902e-13 NA NA NA hsa-miR-335-3p CD59 3.08791651139852 5.31309869723517e-12 -0.701153559236412 0.00130409241528683 mirMAP -0.101202691439114 9.39618721243129e-06 NA NA NA hsa-miR-92a-3p CD59 2.06460102658973 1.44784291084757e-19 -0.701153559236412 0.00130409241528683 miRNAWalker2_validate -0.153600890486695 0.000556271855695747 NA NA NA hsa-miR-98-5p CD59 1.11154309866014 1.24143909012085e-08 -0.701153559236412 0.00130409241528683 MirTarget -0.3011218186078 1.43177904538973e-08 NA NA NA hsa-miR-126-5p CDH11 0.895338176458417 2.33372756450713e-05 -1.40395286200645 0.00163179991495068 mirMAP -0.379677828132698 0.000196105076741087 NA NA NA hsa-miR-130b-3p CDH11 3.5350292994509 1.73934183852569e-27 -1.40395286200645 0.00163179991495068 mirMAP -0.451103594960395 1.01493009118139e-13 NA NA NA hsa-miR-144-5p CDH11 0.195856574290527 0.61856475838049 -1.40395286200645 0.00163179991495068 mirMAP -0.321547180415418 3.03292923893988e-09 NA NA NA hsa-miR-16-2-3p CDH11 2.31623086727196 4.29838149388188e-20 -1.40395286200645 0.00163179991495068 mirMAP -0.71597652307981 9.70167799981015e-20 NA NA NA hsa-miR-181a-2-3p CDH11 2.19062681262366 3.81790102612782e-13 -1.40395286200645 0.00163179991495068 mirMAP -0.406808114559531 3.30454845947709e-09 NA NA NA hsa-miR-200b-3p CDH11 3.78235093249346 3.18343003239465e-14 -1.40395286200645 0.00163179991495068 TargetScan -0.32930359343724 5.195555865728e-16 NA NA NA hsa-miR-224-3p CDH11 1.87536386559317 6.15140969394846e-05 -1.40395286200645 0.00163179991495068 mirMAP -0.300115719879844 1.90015230006987e-10 NA NA NA hsa-miR-301a-3p CDH11 2.81024345929638 2.29784847962242e-17 -1.40395286200645 0.00163179991495068 mirMAP -0.575063449509654 1.63375759368773e-19 NA NA NA hsa-miR-32-3p CDH11 2.02436999565685 5.94091197945307e-09 -1.40395286200645 0.00163179991495068 mirMAP -0.5474948170758 4.98160027433374e-16 NA NA NA hsa-miR-320a CDH11 0.438165828017084 0.0390159073347133 -1.40395286200645 0.00163179991495068 miRanda -0.704943936600093 2.15627002642262e-12 NA NA NA hsa-miR-320b CDH11 1.55692969039548 1.41071034251915e-08 -1.40395286200645 0.00163179991495068 miRanda -0.628914312802042 5.20273994655165e-17 NA NA NA hsa-miR-421 CDH11 1.17791565395543 6.78526676976629e-06 -1.40395286200645 0.00163179991495068 miRanda -0.512182359827491 2.43152037930447e-10 NA NA NA hsa-miR-429 CDH11 4.48815175680773 2.44117492218206e-17 -1.40395286200645 0.00163179991495068 PITA;miRanda -0.298594903111114 3.71714476547475e-15 NA NA NA hsa-miR-454-3p CDH11 2.47234127820054 1.12878018736016e-21 -1.40395286200645 0.00163179991495068 mirMAP -0.656004647241797 1.28894624820298e-16 NA NA NA hsa-miR-500a-5p CDH11 1.72110365584658 3.0807246212659e-10 -1.40395286200645 0.00163179991495068 mirMAP -0.203578460122442 0.00898903995731749 NA NA NA hsa-miR-576-5p CDH11 2.20467023993664 3.4053475193793e-19 -1.40395286200645 0.00163179991495068 PITA;mirMAP;miRNATAP -0.606236910542702 1.7067738564707e-13 NA NA NA hsa-miR-590-3p CDH11 2.59289455139753 1.03200520972022e-21 -1.40395286200645 0.00163179991495068 miRanda;mirMAP -0.547476805451812 7.47437608029262e-13 NA NA NA hsa-miR-7-1-3p CDH11 1.84950311431067 1.25300363397654e-13 -1.40395286200645 0.00163179991495068 mirMAP -0.571884846187848 4.49066536544085e-12 NA NA NA hsa-miR-944 CDH11 2.91186649218281 1.31574753528144e-06 -1.40395286200645 0.00163179991495068 mirMAP -0.288673949626701 3.55508401599234e-16 NA NA NA hsa-miR-194-5p CDH2 1.8992998339217 3.76507853301977e-10 -0.373871027920648 0.510070676503065 miRNAWalker2_validate;miRTarBase;miRNATAP -0.649395196478716 5.02723808836733e-14 21845495;20979124 The results of real-time PCR and western blot highlighted that miR-194 interacted with N-cadherin and negatively regulated its expression at the translational level;The overexpression of miR-194 in liver mesenchymal-like cancer cells reduced the expression of the mesenchymal cell marker N-cadherin and suppressed invasion and migration of the mesenchymal-like cancer cells both in vitro and in vivo ; gastric cancer;liver cancer hsa-miR-26b-5p CDH2 0.885393662798425 3.2116297961629e-06 -0.373871027920648 0.510070676503065 miRNATAP -0.612777206574385 1.9569222676156e-05 NA NA NA hsa-miR-320a CDH2 0.438165828017084 0.0390159073347133 -0.373871027920648 0.510070676503065 MirTarget;PITA;miRanda;miRNATAP -0.786371818033375 8.02407357117233e-10 NA NA NA hsa-miR-320b CDH2 1.55692969039548 1.41071034251915e-08 -0.373871027920648 0.510070676503065 MirTarget;PITA;miRanda;miRNATAP -0.532797426255311 4.33613853026582e-08 NA NA NA hsa-miR-3607-3p CDH2 2.68532138541128 5.66716351955047e-14 -0.373871027920648 0.510070676503065 MirTarget;miRNATAP -0.361059375388227 1.9120479998616e-06 NA NA NA hsa-miR-361-3p CDH2 1.07367425434318 1.73142774168958e-09 -0.373871027920648 0.510070676503065 miRNATAP -0.635633930503043 2.93022104840319e-05 NA NA NA hsa-miR-361-5p CDH2 0.971859117235239 5.30236555707088e-09 -0.373871027920648 0.510070676503065 miRanda -0.897812745721253 3.17980553853679e-08 NA NA NA hsa-miR-429 CDH2 4.48815175680773 2.44117492218206e-17 -0.373871027920648 0.510070676503065 miRanda -0.326677021928677 1.72435717237418e-11 NA NA NA hsa-miR-452-5p CDH2 1.37180058737183 0.00171494843537772 -0.373871027920648 0.510070676503065 miRNATAP -0.248624567859048 6.16781915331156e-05 NA NA NA hsa-miR-532-3p CDH2 1.96631878320218 4.53421954361695e-13 -0.373871027920648 0.510070676503065 PITA -0.525610694606806 6.41601391315426e-08 NA NA NA hsa-miR-582-5p CDH2 0.609226359812689 0.032988717891497 -0.373871027920648 0.510070676503065 miRNATAP -0.425433150996433 8.40108759505727e-06 NA NA NA hsa-miR-590-3p CDH2 2.59289455139753 1.03200520972022e-21 -0.373871027920648 0.510070676503065 miRanda -0.367251256776844 0.000203351701897724 NA NA NA hsa-miR-7-1-3p CDH2 1.84950311431067 1.25300363397654e-13 -0.373871027920648 0.510070676503065 mirMAP -0.305085912880369 0.00440386521382496 NA NA NA hsa-miR-155-5p CDH6 1.20164021433135 0.00086170622431261 -0.982062552967181 0.000735367457247465 miRNAWalker2_validate -0.14983541211419 0.000115438008146056 NA NA NA hsa-miR-15b-3p CDH6 2.33847028227712 4.29662877950836e-19 -0.982062552967181 0.000735367457247465 mirMAP -0.214972753422073 3.04044392647111e-05 NA NA NA hsa-miR-186-5p CDH6 1.47445398888668 3.0781726595413e-15 -0.982062552967181 0.000735367457247465 mirMAP -0.352664134410359 1.49171980550893e-06 NA NA NA hsa-miR-20a-3p CDH6 2.92621109947706 2.49504904635375e-17 -0.982062552967181 0.000735367457247465 mirMAP -0.189686392250969 2.20591673664921e-06 NA NA NA hsa-miR-24-2-5p CDH6 2.07171035460647 3.15853539996136e-16 -0.982062552967181 0.000735367457247465 MirTarget -0.26032953873407 1.11274904461898e-06 NA NA NA hsa-miR-29a-5p CDH6 1.46749674755271 3.34605004270294e-07 -0.982062552967181 0.000735367457247465 mirMAP -0.229520858757759 7.00391898913265e-06 NA NA NA hsa-miR-32-3p CDH6 2.02436999565685 5.94091197945307e-09 -0.982062552967181 0.000735367457247465 mirMAP -0.127441668033364 0.00517710964629277 NA NA NA hsa-miR-339-5p CDH6 2.68710938429893 3.03134080808154e-16 -0.982062552967181 0.000735367457247465 miRanda -0.194490166615473 2.24745065993249e-06 NA NA NA hsa-miR-3607-3p CDH6 2.68532138541128 5.66716351955047e-14 -0.982062552967181 0.000735367457247465 mirMAP -0.142763222392504 0.000280187114463574 NA NA NA hsa-miR-502-3p CDH6 1.50560877085049 1.2647489756373e-11 -0.982062552967181 0.000735367457247465 MirTarget -0.214014197697097 0.000596155005654538 NA NA NA hsa-miR-576-5p CDH6 2.20467023993664 3.4053475193793e-19 -0.982062552967181 0.000735367457247465 PITA;mirMAP -0.287817422475374 1.31169788808115e-07 NA NA NA hsa-miR-590-3p CDH6 2.59289455139753 1.03200520972022e-21 -0.982062552967181 0.000735367457247465 miRanda -0.266996631791025 1.26928242396229e-07 NA NA NA hsa-miR-7-1-3p CDH6 1.84950311431067 1.25300363397654e-13 -0.982062552967181 0.000735367457247465 mirMAP -0.278787093909109 3.36054596137892e-07 NA NA NA hsa-miR-708-3p CDH6 2.80907765282502 3.07460722669281e-14 -0.982062552967181 0.000735367457247465 MirTarget -0.104057905619695 0.00494605439055912 NA NA NA hsa-miR-944 CDH6 2.91186649218281 1.31574753528144e-06 -0.982062552967181 0.000735367457247465 PITA;miRNATAP -0.109596413024017 3.8772510414963e-06 NA NA NA hsa-let-7a-5p COL11A1 0.618599506841644 2.76973453058748e-05 4.68886927590747 2.15659824797734e-08 TargetScan -0.893168609837919 0.00159985520751616 NA NA NA hsa-miR-126-5p COL11A1 0.895338176458417 2.33372756450713e-05 4.68886927590747 2.15659824797734e-08 MirTarget;mirMAP -0.604217487453625 0.00189768374214306 NA NA NA hsa-miR-129-5p COL11A1 -0.524170159980738 0.222582956006346 4.68886927590747 2.15659824797734e-08 PITA;miRanda;mirMAP;miRNATAP -0.465304273591551 1.58905773119641e-06 NA NA NA hsa-miR-139-5p COL11A1 -1.52606598644743 1.20474151350665e-08 4.68886927590747 2.15659824797734e-08 miRanda -0.609369414390997 5.51598461400947e-05 NA NA NA hsa-miR-141-3p COL11A1 5.02396127982626 2.19224509139725e-24 4.68886927590747 2.15659824797734e-08 miRNATAP -0.226787669474765 0.00396629375366405 NA NA NA hsa-miR-200a-3p COL11A1 4.59434485520731 6.38952518573476e-18 4.68886927590747 2.15659824797734e-08 miRNATAP -0.269705680924126 0.000259846391421803 NA NA NA hsa-miR-200c-5p COL11A1 2.95761105443819 3.11105707262802e-11 4.68886927590747 2.15659824797734e-08 MirTarget;miRNATAP -0.57292334566073 1.32296460501734e-09 NA NA NA hsa-miR-25-3p COL11A1 1.36472605225697 4.83790725935681e-11 4.68886927590747 2.15659824797734e-08 MirTarget -0.574891297220065 0.0033019878878065 NA NA NA hsa-miR-29c-3p COL11A1 -0.00968972577705429 0.97099586346872 4.68886927590747 2.15659824797734e-08 MirTarget;miRNATAP -0.786307511283254 3.22713982483742e-07 NA NA NA hsa-miR-32-3p COL11A1 2.02436999565685 5.94091197945307e-09 4.68886927590747 2.15659824797734e-08 miRNATAP -0.604550355446293 4.54722968471728e-06 NA NA NA hsa-miR-324-3p COL11A1 2.08739139768981 3.11885987067952e-13 4.68886927590747 2.15659824797734e-08 PITA -0.730088790764634 1.3619608898915e-07 NA NA NA hsa-miR-361-5p COL11A1 0.971859117235239 5.30236555707088e-09 4.68886927590747 2.15659824797734e-08 miRanda;miRNATAP -0.974519291708224 7.48449987820013e-05 NA NA NA hsa-miR-363-3p COL11A1 1.50575300026701 0.00020976164678918 4.68886927590747 2.15659824797734e-08 MirTarget -0.485703678815513 1.1738934410769e-06 NA NA NA hsa-miR-421 COL11A1 1.17791565395543 6.78526676976629e-06 4.68886927590747 2.15659824797734e-08 miRanda -0.480623055605035 0.00217252469052272 NA NA NA hsa-miR-429 COL11A1 4.48815175680773 2.44117492218206e-17 4.68886927590747 2.15659824797734e-08 miRanda -0.238982094102862 0.00133398170778998 NA NA NA hsa-miR-664a-3p COL11A1 0.634721925861133 0.00520070178640421 4.68886927590747 2.15659824797734e-08 mirMAP -0.688555863520752 0.000148838164300729 NA NA NA hsa-miR-92a-3p COL11A1 2.06460102658973 1.44784291084757e-19 4.68886927590747 2.15659824797734e-08 MirTarget -0.574616774836521 0.00091879934004853 NA NA NA hsa-miR-107 COL12A1 1.30977326593435 1.30372468603965e-11 0.611588153376471 0.134337648747937 miRanda -0.415548039571753 3.31818977234656e-05 NA NA NA hsa-miR-126-5p COL12A1 0.895338176458417 2.33372756450713e-05 0.611588153376471 0.134337648747937 mirMAP -0.255079117060311 0.006296148773703 NA NA NA hsa-miR-1301-3p COL12A1 2.54959518791507 5.26618591274892e-18 0.611588153376471 0.134337648747937 MirTarget -0.197876857261291 0.00210778591142265 NA NA NA hsa-miR-15a-5p COL12A1 2.34669284378787 1.69544424500258e-23 0.611588153376471 0.134337648747937 MirTarget;miRNATAP -0.296860390936073 0.000195709402124528 NA NA NA hsa-miR-15b-5p COL12A1 1.57112623124278 9.14247846750597e-13 0.611588153376471 0.134337648747937 MirTarget;miRNATAP -0.387207593843137 9.3841273546655e-06 NA NA NA hsa-miR-16-5p COL12A1 1.75824877145857 1.68592440033108e-16 0.611588153376471 0.134337648747937 MirTarget;miRNATAP -0.359420864310757 5.89426535121521e-05 NA NA NA hsa-miR-17-3p COL12A1 2.2704817679209 1.1667437320211e-22 0.611588153376471 0.134337648747937 MirTarget;miRNATAP -0.28500664006351 0.000438038496851266 NA NA NA hsa-miR-25-3p COL12A1 1.36472605225697 4.83790725935681e-11 0.611588153376471 0.134337648747937 miRNATAP -0.383045047491847 4.05890692715217e-05 NA NA NA hsa-miR-30b-5p COL12A1 0.800822374912712 0.000133601914525413 0.611588153376471 0.134337648747937 mirMAP -0.390302829788956 3.24392312580777e-05 NA NA NA hsa-miR-30c-5p COL12A1 0.778774633108 0.000285599212429136 0.611588153376471 0.134337648747937 mirMAP -0.51866294090363 1.17256395894654e-08 NA NA NA hsa-miR-30d-3p COL12A1 0.977747550180601 4.3048212205381e-05 0.611588153376471 0.134337648747937 miRNATAP -0.498258547961275 8.21059870696291e-10 NA NA NA hsa-miR-30d-5p COL12A1 0.675423997639582 0.00270618816039773 0.611588153376471 0.134337648747937 mirMAP -0.652354937284425 2.35293481812011e-14 NA NA NA hsa-miR-330-5p COL12A1 1.15100069700871 4.85551805046014e-07 0.611588153376471 0.134337648747937 miRanda -0.25759436733997 0.00267090040736723 NA NA NA hsa-miR-34a-5p COL12A1 1.9016323452565 1.43092834643601e-14 0.611588153376471 0.134337648747937 MirTarget;miRNATAP -0.279272089437204 0.00031460547783989 NA NA NA hsa-miR-375 COL12A1 1.13910305294079 0.0512283522214186 0.611588153376471 0.134337648747937 miRNAWalker2_validate -0.137117632615828 4.32321254535545e-05 NA NA NA hsa-miR-484 COL12A1 1.81844463411787 1.82951571230938e-15 0.611588153376471 0.134337648747937 miRNATAP -0.233732316808539 0.00538098997208253 NA NA NA hsa-miR-532-5p COL12A1 1.55697650978597 1.57884735535196e-11 0.611588153376471 0.134337648747937 PITA -0.248625324244839 0.00305389649703677 NA NA NA hsa-miR-671-3p COL12A1 2.20199226665068 7.0886613366934e-16 0.611588153376471 0.134337648747937 PITA -0.252105498326932 0.000312009812930102 NA NA NA hsa-miR-9-5p COL12A1 1.02304182473283 0.042901377604859 0.611588153376471 0.134337648747937 miRNAWalker2_validate;miRNATAP -0.11638856005246 0.00281817033880054 NA NA NA hsa-miR-92a-3p COL12A1 2.06460102658973 1.44784291084757e-19 0.611588153376471 0.134337648747937 miRNATAP -0.405737194215338 8.62801314235563e-07 NA NA NA hsa-miR-940 COL12A1 3.21011374578759 2.7923171128495e-14 0.611588153376471 0.134337648747937 PITA -0.189251090533472 0.000123495189460981 NA NA NA hsa-miR-181c-5p COL16A1 1.58587920618301 1.57506918816933e-10 -1.74316119402578 0.000168695054312233 MirTarget -0.278847668489617 0.00181819408147632 NA NA NA hsa-miR-29b-3p COL16A1 1.65828197923813 1.02676780888141e-09 -1.74316119402578 0.000168695054312233 miRNATAP -0.27702738739081 0.000682453946037666 NA NA NA hsa-miR-29c-3p COL16A1 -0.00968972577705429 0.97099586346872 -1.74316119402578 0.000168695054312233 miRNATAP -0.455124600494216 6.27855845762623e-08 NA NA NA hsa-miR-3065-3p COL16A1 2.16221780121195 9.65525739884541e-09 -1.74316119402578 0.000168695054312233 MirTarget;miRNATAP -0.173545195078008 0.00316489951801539 NA NA NA hsa-miR-3065-5p COL16A1 2.74629919868982 1.86846589298284e-08 -1.74316119402578 0.000168695054312233 MirTarget -0.19106616706999 0.00058383123589689 NA NA NA hsa-miR-486-5p COL16A1 -0.194913133034028 0.607377798807705 -1.74316119402578 0.000168695054312233 miRanda -0.280325771733842 2.07535753745289e-06 NA NA NA hsa-miR-491-5p COL16A1 0.615770352820862 0.0418295628761654 -1.74316119402578 0.000168695054312233 miRanda -0.307704220985141 0.000115287609327373 NA NA NA hsa-miR-590-3p COL16A1 2.59289455139753 1.03200520972022e-21 -1.74316119402578 0.000168695054312233 miRanda -0.464420237517514 7.72810172370702e-09 NA NA NA hsa-let-7a-5p COL1A1 0.618599506841644 2.76973453058748e-05 -0.110889675073027 0.820072046630299 TargetScan;miRNATAP -0.975861159435873 8.61416320768625e-10 NA NA NA hsa-let-7b-5p COL1A1 0.604314269683977 0.00140009936153214 -0.110889675073027 0.820072046630299 miRNATAP -0.443124127266192 0.000399485996123428 NA NA NA hsa-let-7d-5p COL1A1 1.33236798905207 1.1741085658466e-13 -0.110889675073027 0.820072046630299 miRNATAP -0.81867235251875 9.37375814517517e-11 NA NA NA hsa-let-7e-5p COL1A1 0.860104282510173 6.04758298373779e-05 -0.110889675073027 0.820072046630299 miRNATAP -0.347601997285448 0.0015429941878112 NA NA NA hsa-let-7f-5p COL1A1 0.495648727272215 0.00355972741198794 -0.110889675073027 0.820072046630299 miRNATAP -0.637858159816604 4.63118529376979e-06 NA NA NA hsa-let-7g-5p COL1A1 1.20061455355116 1.50237505511483e-12 -0.110889675073027 0.820072046630299 miRNATAP -1.09424520257645 1.39176730688231e-16 NA NA NA hsa-miR-106a-5p COL1A1 2.48882002962836 1.99757727374521e-12 -0.110889675073027 0.820072046630299 mirMAP -0.435796609970468 5.9115479947617e-12 NA NA NA hsa-miR-106b-5p COL1A1 2.46782146831112 1.36171495805632e-23 -0.110889675073027 0.820072046630299 mirMAP -0.785038282718627 1.75260912749901e-19 NA NA NA hsa-miR-107 COL1A1 1.30977326593435 1.30372468603965e-11 -0.110889675073027 0.820072046630299 PITA;miRanda -0.871419734903876 8.19788155995674e-14 NA NA NA hsa-miR-126-5p COL1A1 0.895338176458417 2.33372756450713e-05 -0.110889675073027 0.820072046630299 miRNATAP -0.352823579048176 0.00150028497759076 NA NA NA hsa-miR-129-5p COL1A1 -0.524170159980738 0.222582956006346 -0.110889675073027 0.820072046630299 miRanda -0.284256940870227 2.72380215920999e-07 NA NA NA hsa-miR-17-5p COL1A1 3.2710598467455 9.93128340539455e-27 -0.110889675073027 0.820072046630299 mirMAP -0.475867326069058 1.83511456036068e-11 NA NA NA hsa-miR-196b-5p COL1A1 1.71646270856386 4.37735885910369e-09 -0.110889675073027 0.820072046630299 miRNATAP -0.373453069766994 2.00605578472263e-06 NA NA NA hsa-miR-20a-5p COL1A1 3.15577933619191 4.19753346442454e-25 -0.110889675073027 0.820072046630299 mirMAP -0.494301670347482 3.77198661227248e-12 NA NA NA hsa-miR-20b-5p COL1A1 2.07706563022469 1.10107236083433e-05 -0.110889675073027 0.820072046630299 mirMAP -0.339124004325201 1.77359442908345e-12 NA NA NA hsa-miR-23a-5p COL1A1 1.46491071577368 0.000241866585858992 -0.110889675073027 0.820072046630299 mirMAP -0.202895794574221 0.00113612726669324 NA NA NA hsa-miR-29b-3p COL1A1 1.65828197923813 1.02676780888141e-09 -0.110889675073027 0.820072046630299 miRNAWalker2_validate;miRTarBase;miRNATAP -0.346531814240984 4.42322074969025e-05 NA NA NA hsa-miR-29c-3p COL1A1 -0.00968972577705429 0.97099586346872 -0.110889675073027 0.820072046630299 miRNAWalker2_validate;miRTarBase;miRNATAP -0.606234586064105 2.82202311553993e-12 NA NA NA hsa-miR-30b-3p COL1A1 0.834142820354026 0.000972582820878813 -0.110889675073027 0.820072046630299 miRNATAP -0.752938614458806 7.53780750895872e-17 NA NA NA hsa-miR-30d-3p COL1A1 0.977747550180601 4.3048212205381e-05 -0.110889675073027 0.820072046630299 mirMAP -0.876999502564275 1.06999478894224e-20 NA NA NA hsa-miR-30e-3p COL1A1 -0.215663037684509 0.235375122783546 -0.110889675073027 0.820072046630299 mirMAP -1.08848274131506 7.81072243881094e-18 NA NA NA hsa-miR-330-3p COL1A1 0.876747334239085 0.00073709016089703 -0.110889675073027 0.820072046630299 mirMAP -0.674963970631739 1.66749586425468e-14 NA NA NA hsa-miR-532-3p COL1A1 1.96631878320218 4.53421954361695e-13 -0.110889675073027 0.820072046630299 PITA;miRNATAP -0.457284092613172 4.2404603042954e-08 NA NA NA hsa-miR-590-3p COL1A1 2.59289455139753 1.03200520972022e-21 -0.110889675073027 0.820072046630299 miRanda -0.409879883063743 1.19715990382964e-06 NA NA NA hsa-miR-625-5p COL1A1 1.42540152147292 1.95797147911206e-06 -0.110889675073027 0.820072046630299 MirTarget -0.295282834517255 0.000543029878293581 NA NA NA hsa-miR-92a-1-5p COL1A1 2.23721820014467 5.12925824784972e-09 -0.110889675073027 0.820072046630299 MirTarget -0.519499753869149 3.68969567887779e-15 NA NA NA hsa-miR-93-5p COL1A1 3.03961860136032 1.11672209617395e-24 -0.110889675073027 0.820072046630299 mirMAP -0.631011490658207 2.16984785580252e-18 NA NA NA hsa-miR-944 COL1A1 2.91186649218281 1.31574753528144e-06 -0.110889675073027 0.820072046630299 PITA;miRNATAP -0.24972943878016 1.67238457219526e-10 NA NA NA hsa-let-7a-3p COL1A2 1.42015538786275 7.03375209382654e-13 -0.907878215431927 0.0536183978525595 MirTarget -0.34337905867058 0.00237172044988904 NA NA NA hsa-let-7a-5p COL1A2 0.618599506841644 2.76973453058748e-05 -0.907878215431927 0.0536183978525595 MirTarget;TargetScan;miRNATAP -1.0007378445628 6.8905642974555e-11 NA NA NA hsa-let-7b-5p COL1A2 0.604314269683977 0.00140009936153214 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.478444481642473 7.47972175420684e-05 NA NA NA hsa-let-7d-5p COL1A2 1.33236798905207 1.1741085658466e-13 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.833365154358605 8.07853763796414e-12 NA NA NA hsa-let-7e-5p COL1A2 0.860104282510173 6.04758298373779e-05 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.319588066942386 0.00262155508152948 NA NA NA hsa-let-7f-5p COL1A2 0.495648727272215 0.00355972741198794 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.633957491871988 2.457417468533e-06 NA NA NA hsa-let-7g-5p COL1A2 1.20061455355116 1.50237505511483e-12 -0.907878215431927 0.0536183978525595 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -1.10610568731162 4.13919461130197e-18 NA NA NA hsa-miR-125a-5p COL1A2 0.599529391575274 0.0102300147180307 -0.907878215431927 0.0536183978525595 miRanda -0.319937796765224 0.00107219463707015 NA NA NA hsa-miR-129-5p COL1A2 -0.524170159980738 0.222582956006346 -0.907878215431927 0.0536183978525595 miRanda -0.229642206791278 1.9113276997333e-05 NA NA NA hsa-miR-196b-5p COL1A2 1.71646270856386 4.37735885910369e-09 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.41200934343234 5.17914353904317e-08 NA NA NA hsa-miR-19a-3p COL1A2 3.42309334186656 3.02671914353412e-28 -0.907878215431927 0.0536183978525595 MirTarget -0.413334735466662 8.74675301182705e-10 NA NA NA hsa-miR-19b-3p COL1A2 2.49529833021187 1.57028265846699e-23 -0.907878215431927 0.0536183978525595 MirTarget -0.615768487699155 2.9812496765956e-13 NA NA NA hsa-miR-25-3p COL1A2 1.36472605225697 4.83790725935681e-11 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.714969163443613 1.39606547277116e-11 NA NA NA hsa-miR-26b-5p COL1A2 0.885393662798425 3.2116297961629e-06 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.600394268231924 4.19125369291339e-07 NA NA NA hsa-miR-29b-3p COL1A2 1.65828197923813 1.02676780888141e-09 -0.907878215431927 0.0536183978525595 miRNATAP -0.37551592391965 4.46023473383405e-06 NA NA NA hsa-miR-29c-3p COL1A2 -0.00968972577705429 0.97099586346872 -0.907878215431927 0.0536183978525595 miRNAWalker2_validate;miRTarBase;miRNATAP -0.552726028389517 5.19310800999508e-11 NA NA NA hsa-miR-30d-3p COL1A2 0.977747550180601 4.3048212205381e-05 -0.907878215431927 0.0536183978525595 MirTarget -0.853220165900042 5.87791108055389e-21 NA NA NA hsa-miR-30e-3p COL1A2 -0.215663037684509 0.235375122783546 -0.907878215431927 0.0536183978525595 MirTarget -0.90580927081412 2.55621171763522e-13 NA NA NA hsa-miR-32-3p COL1A2 2.02436999565685 5.94091197945307e-09 -0.907878215431927 0.0536183978525595 miRNATAP -0.536353098180589 5.67801057528553e-14 NA NA NA hsa-miR-32-5p COL1A2 2.34056473219422 6.24134585974322e-20 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.48256717723832 9.18871844795078e-09 NA NA NA hsa-miR-330-5p COL1A2 1.15100069700871 4.85551805046014e-07 -0.907878215431927 0.0536183978525595 miRanda -0.496611927247797 3.93209191587865e-07 NA NA NA hsa-miR-33a-3p COL1A2 1.72765312072219 1.51784443453521e-07 -0.907878215431927 0.0536183978525595 MirTarget -0.679993547467201 2.17692389592669e-21 NA NA NA hsa-miR-363-3p COL1A2 1.50575300026701 0.00020976164678918 -0.907878215431927 0.0536183978525595 MirTarget -0.353877286078259 9.32755334167874e-11 NA NA NA hsa-miR-590-3p COL1A2 2.59289455139753 1.03200520972022e-21 -0.907878215431927 0.0536183978525595 miRanda -0.440962251043098 5.92080348086989e-08 NA NA NA hsa-miR-7-1-3p COL1A2 1.84950311431067 1.25300363397654e-13 -0.907878215431927 0.0536183978525595 mirMAP -0.450201118044729 3.14014784977594e-07 NA NA NA hsa-miR-92a-3p COL1A2 2.06460102658973 1.44784291084757e-19 -0.907878215431927 0.0536183978525595 MirTarget;miRNATAP -0.833093472607066 1.25536202925879e-19 NA NA NA hsa-miR-98-5p COL1A2 1.11154309866014 1.24143909012085e-08 -0.907878215431927 0.0536183978525595 MirTarget -0.757659815957651 2.42759440753309e-11 NA NA NA hsa-let-7a-5p COL3A1 0.618599506841644 2.76973453058748e-05 -0.565788034550078 0.246314759619422 MirTarget;TargetScan;miRNATAP -1.07145991445666 1.44341471794239e-11 NA NA NA hsa-let-7b-5p COL3A1 0.604314269683977 0.00140009936153214 -0.565788034550078 0.246314759619422 MirTarget;miRNATAP -0.520370108467715 3.15541473418739e-05 NA NA NA hsa-let-7d-5p COL3A1 1.33236798905207 1.1741085658466e-13 -0.565788034550078 0.246314759619422 MirTarget;miRNATAP -0.9083624396231 5.35680683946596e-13 NA NA NA hsa-let-7e-5p COL3A1 0.860104282510173 6.04758298373779e-05 -0.565788034550078 0.246314759619422 MirTarget;miRNATAP -0.395591758482046 0.000313922597261782 NA NA NA hsa-let-7f-5p COL3A1 0.495648727272215 0.00355972741198794 -0.565788034550078 0.246314759619422 MirTarget;miRNATAP -0.639444265087128 4.55812943036027e-06 NA NA NA hsa-let-7g-5p COL3A1 1.20061455355116 1.50237505511483e-12 -0.565788034550078 0.246314759619422 MirTarget;miRNATAP -1.14041136915299 6.16680490343563e-18 NA NA NA hsa-miR-107 COL3A1 1.30977326593435 1.30372468603965e-11 -0.565788034550078 0.246314759619422 miRanda -0.900353231812637 1.17801590550461e-14 NA NA NA hsa-miR-128-3p COL3A1 1.63756041666078 6.79626586407187e-14 -0.565788034550078 0.246314759619422 MirTarget -0.821797813132761 7.80329374909819e-16 NA NA NA hsa-miR-129-5p COL3A1 -0.524170159980738 0.222582956006346 -0.565788034550078 0.246314759619422 miRanda -0.268368895471698 1.31827203401084e-06 NA NA NA hsa-miR-141-5p COL3A1 3.81419396518882 3.21977359736126e-18 -0.565788034550078 0.246314759619422 MirTarget -0.473900653561283 4.41831820767733e-22 NA NA NA hsa-miR-16-2-3p COL3A1 2.31623086727196 4.29838149388188e-20 -0.565788034550078 0.246314759619422 MirTarget -0.61725944427009 1.67679439371481e-12 NA NA NA hsa-miR-186-5p COL3A1 1.47445398888668 3.0781726595413e-15 -0.565788034550078 0.246314759619422 miRNATAP -0.83830177957091 3.49448416483159e-12 NA NA NA hsa-miR-196b-5p COL3A1 1.71646270856386 4.37735885910369e-09 -0.565788034550078 0.246314759619422 MirTarget;miRNATAP -0.392356653666758 5.99602729405653e-07 NA NA NA hsa-miR-29b-3p COL3A1 1.65828197923813 1.02676780888141e-09 -0.565788034550078 0.246314759619422 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.395548823994068 3.04695074686131e-06 NA NA NA hsa-miR-29c-3p COL3A1 -0.00968972577705429 0.97099586346872 -0.565788034550078 0.246314759619422 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.542329131614372 5.60248389461275e-10 NA NA NA hsa-miR-330-5p COL3A1 1.15100069700871 4.85551805046014e-07 -0.565788034550078 0.246314759619422 miRanda -0.520381426564146 2.86308305592651e-07 NA NA NA hsa-miR-335-3p COL3A1 3.08791651139852 5.31309869723517e-12 -0.565788034550078 0.246314759619422 mirMAP -0.166570296141103 0.00113875611204499 NA NA NA hsa-miR-335-5p COL3A1 1.77247705492746 2.22457658872091e-06 -0.565788034550078 0.246314759619422 miRNAWalker2_validate -0.176728391770204 0.00452966296843607 NA NA NA hsa-miR-421 COL3A1 1.17791565395543 6.78526676976629e-06 -0.565788034550078 0.246314759619422 miRanda -0.440385399230824 7.38832022598602e-07 NA NA NA hsa-miR-429 COL3A1 4.48815175680773 2.44117492218206e-17 -0.565788034550078 0.246314759619422 miRanda -0.367528026621427 2.69025053877136e-19 NA NA NA hsa-miR-582-3p COL3A1 0.00876844181512659 0.977126166214707 -0.565788034550078 0.246314759619422 miRNATAP -0.42606804047543 2.43250216408206e-08 NA NA NA hsa-miR-590-3p COL3A1 2.59289455139753 1.03200520972022e-21 -0.565788034550078 0.246314759619422 miRanda;mirMAP -0.47143263417752 2.13128444746099e-08 NA NA NA hsa-miR-590-5p COL3A1 3.18300989862077 2.06813568597893e-26 -0.565788034550078 0.246314759619422 miRanda -0.450615582006524 1.80347464014817e-09 NA NA NA hsa-miR-653-5p COL3A1 1.95532430599881 1.08864209905068e-07 -0.565788034550078 0.246314759619422 MirTarget -0.280999436343887 7.98249922626046e-06 NA NA NA hsa-miR-98-5p COL3A1 1.11154309866014 1.24143909012085e-08 -0.565788034550078 0.246314759619422 MirTarget -0.780541547644691 3.17104353678789e-11 NA NA NA hsa-let-7a-3p COL4A1 1.42015538786275 7.03375209382654e-13 0.151465916664922 0.581694470985045 miRNATAP -0.207862002239419 0.00158784209627186 NA NA NA hsa-let-7a-5p COL4A1 0.618599506841644 2.76973453058748e-05 0.151465916664922 0.581694470985045 TargetScan;miRNATAP -0.442098228023527 1.00399459970798e-06 NA NA NA hsa-let-7b-5p COL4A1 0.604314269683977 0.00140009936153214 0.151465916664922 0.581694470985045 miRNATAP -0.260987692213768 0.00021341519200331 NA NA NA hsa-let-7f-5p COL4A1 0.495648727272215 0.00355972741198794 0.151465916664922 0.581694470985045 miRNATAP -0.294689845868312 0.000184159897657789 NA NA NA hsa-let-7g-5p COL4A1 1.20061455355116 1.50237505511483e-12 0.151465916664922 0.581694470985045 miRNATAP -0.457888848569706 1.70166576381862e-09 NA NA NA hsa-miR-125a-5p COL4A1 0.599529391575274 0.0102300147180307 0.151465916664922 0.581694470985045 miRNAWalker2_validate;miRanda -0.196409517018995 0.000565233811607909 NA NA NA hsa-miR-148a-3p COL4A1 1.26728238710376 2.52325607402829e-06 0.151465916664922 0.581694470985045 miRNATAP -0.227396815859122 2.77390532352486e-06 NA NA NA hsa-miR-16-5p COL4A1 1.75824877145857 1.68592440033108e-16 0.151465916664922 0.581694470985045 miRNAWalker2_validate -0.273095281738351 5.23183239600475e-06 NA NA NA hsa-miR-17-5p COL4A1 3.2710598467455 9.93128340539455e-27 0.151465916664922 0.581694470985045 TargetScan -0.190337705152129 2.54377799768868e-06 NA NA NA hsa-miR-205-5p COL4A1 4.1389800495524 2.05488295686453e-12 0.151465916664922 0.581694470985045 miRNATAP -0.148667493224682 3.51597977558842e-12 NA NA NA hsa-miR-29b-3p COL4A1 1.65828197923813 1.02676780888141e-09 0.151465916664922 0.581694470985045 miRNAWalker2_validate;miRTarBase;miRNATAP -0.260273590677078 4.10687060161825e-08 NA NA NA hsa-miR-29c-3p COL4A1 -0.00968972577705429 0.97099586346872 0.151465916664922 0.581694470985045 miRNAWalker2_validate;miRTarBase;miRNATAP -0.273632347235992 3.08821831062353e-08 NA NA NA hsa-miR-3065-5p COL4A1 2.74629919868982 1.86846589298284e-08 0.151465916664922 0.581694470985045 miRNATAP -0.11834270493481 0.000288906172625696 NA NA NA hsa-miR-320a COL4A1 0.438165828017084 0.0390159073347133 0.151465916664922 0.581694470985045 miRanda -0.292390284980215 2.90823813846283e-06 NA NA NA hsa-miR-320b COL4A1 1.55692969039548 1.41071034251915e-08 0.151465916664922 0.581694470985045 miRanda -0.225426369231117 1.86319037296535e-06 NA NA NA hsa-miR-330-5p COL4A1 1.15100069700871 4.85551805046014e-07 0.151465916664922 0.581694470985045 miRanda -0.163276523355723 0.00463020888504854 NA NA NA hsa-miR-362-3p COL4A1 2.0756816987665 3.89026064579331e-12 0.151465916664922 0.581694470985045 miRanda -0.117789768617334 0.00857528731771554 NA NA NA hsa-miR-429 COL4A1 4.48815175680773 2.44117492218206e-17 0.151465916664922 0.581694470985045 miRanda;miRNATAP -0.170995787476466 2.64041159335847e-13 NA NA NA hsa-miR-590-3p COL4A1 2.59289455139753 1.03200520972022e-21 0.151465916664922 0.581694470985045 miRanda -0.196848804346619 3.75186434917263e-05 NA NA NA hsa-miR-590-5p COL4A1 3.18300989862077 2.06813568597893e-26 0.151465916664922 0.581694470985045 miRanda;miRNATAP -0.183813053545641 1.58532123855151e-05 NA NA NA hsa-miR-769-3p COL4A1 2.19896922202687 5.69250370895053e-12 0.151465916664922 0.581694470985045 miRNAWalker2_validate -0.208132027501523 4.98704429599058e-07 NA NA NA hsa-miR-92a-3p COL4A1 2.06460102658973 1.44784291084757e-19 0.151465916664922 0.581694470985045 miRNAWalker2_validate -0.290767640334324 1.44691249323084e-07 NA NA NA hsa-let-7a-5p COL4A2 0.618599506841644 2.76973453058748e-05 -0.27910991086701 0.308355154850744 TargetScan;miRNATAP -0.555056049505749 5.22435747579625e-10 NA NA NA hsa-let-7b-5p COL4A2 0.604314269683977 0.00140009936153214 -0.27910991086701 0.308355154850744 miRNATAP -0.315567704720702 6.54540039466691e-06 NA NA NA hsa-let-7e-5p COL4A2 0.860104282510173 6.04758298373779e-05 -0.27910991086701 0.308355154850744 miRNATAP -0.159408726979961 0.00989974004128267 NA NA NA hsa-let-7f-5p COL4A2 0.495648727272215 0.00355972741198794 -0.27910991086701 0.308355154850744 miRNATAP -0.365132449467995 3.02342955523422e-06 NA NA NA hsa-let-7g-5p COL4A2 1.20061455355116 1.50237505511483e-12 -0.27910991086701 0.308355154850744 miRNATAP -0.557185574693694 1.0518017366577e-13 NA NA NA hsa-miR-10a-5p COL4A2 1.15016989191194 0.00372037233992369 -0.27910991086701 0.308355154850744 miRNAWalker2_validate -0.171332545245499 1.86859577879628e-07 NA NA NA hsa-miR-1266-5p COL4A2 1.3763848124288 0.000876906064212958 -0.27910991086701 0.308355154850744 MirTarget -0.190223128284874 1.49525127120344e-09 NA NA NA hsa-miR-16-5p COL4A2 1.75824877145857 1.68592440033108e-16 -0.27910991086701 0.308355154850744 miRNAWalker2_validate -0.378894147531602 1.40485603477633e-10 NA NA NA hsa-miR-26b-5p COL4A2 0.885393662798425 3.2116297961629e-06 -0.27910991086701 0.308355154850744 miRNAWalker2_validate -0.419978526666598 8.53353167401164e-10 NA NA NA hsa-miR-29b-3p COL4A2 1.65828197923813 1.02676780888141e-09 -0.27910991086701 0.308355154850744 miRTarBase;MirTarget;miRNATAP -0.246645870557632 1.93495146133022e-07 NA NA NA hsa-miR-29c-3p COL4A2 -0.00968972577705429 0.97099586346872 -0.27910991086701 0.308355154850744 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.268164535791781 5.36677401020056e-08 NA NA NA hsa-miR-92a-3p COL4A2 2.06460102658973 1.44784291084757e-19 -0.27910991086701 0.308355154850744 miRNAWalker2_validate -0.366419003795853 1.87188534268414e-11 NA NA NA hsa-miR-107 COL5A1 1.30977326593435 1.30372468603965e-11 -0.222094081280337 0.629223464800652 miRanda -0.795219212865109 5.78126939817183e-13 NA NA NA hsa-miR-129-5p COL5A1 -0.524170159980738 0.222582956006346 -0.222094081280337 0.629223464800652 miRanda -0.243797320006032 3.15364520759059e-06 NA NA NA hsa-miR-192-5p COL5A1 2.69002528723195 1.22990188194432e-16 -0.222094081280337 0.629223464800652 miRNATAP -0.472370039697907 1.80558205891843e-13 NA NA NA hsa-miR-224-3p COL5A1 1.87536386559317 6.15140969394846e-05 -0.222094081280337 0.629223464800652 mirMAP -0.261381926494596 7.95538266128474e-08 NA NA NA hsa-miR-25-3p COL5A1 1.36472605225697 4.83790725935681e-11 -0.222094081280337 0.629223464800652 miRNATAP -0.657847834356415 2.11269081457058e-10 NA NA NA hsa-miR-26b-5p COL5A1 0.885393662798425 3.2116297961629e-06 -0.222094081280337 0.629223464800652 miRNAWalker2_validate;miRNATAP -0.588402477502019 3.72095838879448e-07 NA NA NA hsa-miR-29b-3p COL5A1 1.65828197923813 1.02676780888141e-09 -0.222094081280337 0.629223464800652 MirTarget;miRNATAP -0.337222168811289 2.49984845183715e-05 NA NA NA hsa-miR-29c-3p COL5A1 -0.00968972577705429 0.97099586346872 -0.222094081280337 0.629223464800652 MirTarget;miRNATAP -0.571150517831696 3.05996519350175e-12 NA NA NA hsa-miR-3065-3p COL5A1 2.16221780121195 9.65525739884541e-09 -0.222094081280337 0.629223464800652 miRNATAP -0.160200637213473 0.00568746017917514 NA NA NA hsa-miR-32-5p COL5A1 2.34056473219422 6.24134585974322e-20 -0.222094081280337 0.629223464800652 miRNATAP -0.420413685238995 3.24642902684387e-07 NA NA NA hsa-miR-3653-3p COL5A1 1.85886928622326 2.98407490336841e-08 -0.222094081280337 0.629223464800652 MirTarget -0.354325830907583 2.15126128461838e-07 NA NA NA hsa-miR-582-5p COL5A1 0.609226359812689 0.032988717891497 -0.222094081280337 0.629223464800652 MirTarget;PITA;miRNATAP -0.507028790979963 3.00312407205844e-11 NA NA NA hsa-miR-590-3p COL5A1 2.59289455139753 1.03200520972022e-21 -0.222094081280337 0.629223464800652 PITA;miRanda;mirMAP;miRNATAP -0.399111832285206 5.27771096675383e-07 NA NA NA hsa-miR-7-1-3p COL5A1 1.84950311431067 1.25300363397654e-13 -0.222094081280337 0.629223464800652 mirMAP -0.397140739889476 4.01439012586989e-06 NA NA NA hsa-miR-744-5p COL5A1 1.48254348878737 3.23019501613577e-09 -0.222094081280337 0.629223464800652 miRNAWalker2_validate -0.620846222564725 3.22273326212775e-13 NA NA NA hsa-miR-9-5p COL5A1 1.02304182473283 0.042901377604859 -0.222094081280337 0.629223464800652 miRNATAP -0.124806741331828 0.00442787931448325 NA NA NA hsa-miR-92a-3p COL5A1 2.06460102658973 1.44784291084757e-19 -0.222094081280337 0.629223464800652 miRNATAP -0.741642309529374 2.43337949958631e-16 NA NA NA hsa-miR-944 COL5A1 2.91186649218281 1.31574753528144e-06 -0.222094081280337 0.629223464800652 PITA -0.226619678448758 8.63828416727715e-10 NA NA NA hsa-let-7a-5p COL5A2 0.618599506841644 2.76973453058748e-05 0.192620068784939 0.640929497139689 MirTarget;TargetScan;miRNATAP -0.832595572403708 6.42917948373526e-10 NA NA NA hsa-let-7b-5p COL5A2 0.604314269683977 0.00140009936153214 0.192620068784939 0.640929497139689 MirTarget;miRNATAP -0.330175352450489 0.00187735051382791 NA NA NA hsa-let-7d-5p COL5A2 1.33236798905207 1.1741085658466e-13 0.192620068784939 0.640929497139689 MirTarget;miRNATAP -0.674161638217012 3.22679284540946e-10 NA NA NA hsa-let-7e-5p COL5A2 0.860104282510173 6.04758298373779e-05 0.192620068784939 0.640929497139689 MirTarget;miRNATAP -0.340809236609287 0.000240109531780014 NA NA NA hsa-let-7f-5p COL5A2 0.495648727272215 0.00355972741198794 0.192620068784939 0.640929497139689 MirTarget;miRNATAP -0.617919672084381 1.44530588673211e-07 NA NA NA hsa-let-7g-5p COL5A2 1.20061455355116 1.50237505511483e-12 0.192620068784939 0.640929497139689 MirTarget;miRNATAP -0.98794235711818 7.8804313108437e-19 NA NA NA hsa-miR-126-5p COL5A2 0.895338176458417 2.33372756450713e-05 0.192620068784939 0.640929497139689 mirMAP -0.295967904711194 0.00166960352751243 NA NA NA hsa-miR-129-5p COL5A2 -0.524170159980738 0.222582956006346 0.192620068784939 0.640929497139689 miRanda -0.201843470172023 1.78880474013962e-05 NA NA NA hsa-miR-148a-5p COL5A2 1.16173838132242 0.000148929299881612 0.192620068784939 0.640929497139689 MirTarget -0.202840208411885 0.00173152068937151 NA NA NA hsa-miR-16-2-3p COL5A2 2.31623086727196 4.29838149388188e-20 0.192620068784939 0.640929497139689 MirTarget;mirMAP -0.359927719999076 1.65092784267021e-06 NA NA NA hsa-miR-181a-2-3p COL5A2 2.19062681262366 3.81790102612782e-13 0.192620068784939 0.640929497139689 MirTarget -0.185279170161162 0.00399157793810911 NA NA NA hsa-miR-224-3p COL5A2 1.87536386559317 6.15140969394846e-05 0.192620068784939 0.640929497139689 MirTarget -0.225009692681603 2.7417131065667e-07 NA NA NA hsa-miR-29b-3p COL5A2 1.65828197923813 1.02676780888141e-09 0.192620068784939 0.640929497139689 MirTarget;miRNATAP -0.312290634798384 1.35600714846716e-05 NA NA NA hsa-miR-29c-3p COL5A2 -0.00968972577705429 0.97099586346872 0.192620068784939 0.640929497139689 MirTarget;miRNATAP -0.60937208074643 4.65965791947289e-17 NA NA NA hsa-miR-30e-3p COL5A2 -0.215663037684509 0.235375122783546 0.192620068784939 0.640929497139689 mirMAP -0.924800644714792 6.09937287454344e-18 NA NA NA hsa-miR-32-3p COL5A2 2.02436999565685 5.94091197945307e-09 0.192620068784939 0.640929497139689 mirMAP -0.394219358716442 4.32795248047308e-10 NA NA NA hsa-miR-330-3p COL5A2 0.876747334239085 0.00073709016089703 0.192620068784939 0.640929497139689 PITA -0.511189606748288 9.65146493529212e-12 NA NA NA hsa-miR-335-3p COL5A2 3.08791651139852 5.31309869723517e-12 0.192620068784939 0.640929497139689 MirTarget -0.137251201913104 0.00152587755273111 NA NA NA hsa-miR-335-5p COL5A2 1.77247705492746 2.22457658872091e-06 0.192620068784939 0.640929497139689 miRNATAP -0.17694465592977 0.000757729208834787 NA NA NA hsa-miR-34a-5p COL5A2 1.9016323452565 1.43092834643601e-14 0.192620068784939 0.640929497139689 MirTarget -0.411001400817508 1.17355783845956e-07 NA NA NA hsa-miR-590-3p COL5A2 2.59289455139753 1.03200520972022e-21 0.192620068784939 0.640929497139689 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.289872142497193 5.41463050810638e-05 NA NA NA hsa-miR-944 COL5A2 2.91186649218281 1.31574753528144e-06 0.192620068784939 0.640929497139689 mirMAP -0.193898631965362 5.45096663973783e-09 NA NA NA hsa-miR-98-5p COL5A2 1.11154309866014 1.24143909012085e-08 0.192620068784939 0.640929497139689 MirTarget -0.644995833112182 9.19737472278961e-11 NA NA NA hsa-miR-29b-3p COL5A3 1.65828197923813 1.02676780888141e-09 0.460593428861118 0.265451122038281 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.208907117569099 0.00389766875317623 NA NA NA hsa-miR-29c-3p COL5A3 -0.00968972577705429 0.97099586346872 0.460593428861118 0.265451122038281 MirTarget;miRNATAP -0.578820634145883 2.33647386785395e-15 NA NA NA hsa-miR-3065-3p COL5A3 2.16221780121195 9.65525739884541e-09 0.460593428861118 0.265451122038281 MirTarget;miRNATAP -0.164217024409297 0.00160362628258138 NA NA NA hsa-miR-330-5p COL5A3 1.15100069700871 4.85551805046014e-07 0.460593428861118 0.265451122038281 miRanda -0.329531149798283 0.000139582635215916 NA NA NA hsa-miR-429 COL5A3 4.48815175680773 2.44117492218206e-17 0.460593428861118 0.265451122038281 miRanda -0.314982548039731 9.5370977766118e-20 NA NA NA hsa-miR-940 COL5A3 3.21011374578759 2.7923171128495e-14 0.460593428861118 0.265451122038281 MirTarget;miRNATAP -0.269367762002061 5.1122151660895e-08 NA NA NA hsa-miR-10a-5p COL6A2 1.15016989191194 0.00372037233992369 -2.09678899778735 1.31305008920322e-06 miRNAWalker2_validate -0.474265837714119 1.27096286007502e-20 NA NA NA hsa-miR-10b-5p COL6A2 -0.155951595811628 0.555006386998027 -2.09678899778735 1.31305008920322e-06 miRNAWalker2_validate -0.525392591874696 3.08091744996193e-11 NA NA NA hsa-miR-1226-3p COL6A3 1.38118928579963 0.000205503474787488 -1.49732720873756 0.000705770797494499 MirTarget -0.486063466215814 2.60407868738001e-14 NA NA NA hsa-miR-29b-3p COL6A3 1.65828197923813 1.02676780888141e-09 -1.49732720873756 0.000705770797494499 MirTarget;miRNATAP -0.375611788882487 1.11448080467985e-06 NA NA NA hsa-miR-29c-3p COL6A3 -0.00968972577705429 0.97099586346872 -1.49732720873756 0.000705770797494499 MirTarget;miRNATAP -0.474613761856899 2.75572162873452e-09 NA NA NA hsa-miR-320a COL6A3 0.438165828017084 0.0390159073347133 -1.49732720873756 0.000705770797494499 miRanda -0.778342280150975 3.56471409360412e-15 NA NA NA hsa-miR-320b COL6A3 1.55692969039548 1.41071034251915e-08 -1.49732720873756 0.000705770797494499 miRanda -0.653373966741597 1.26383391262323e-18 NA NA NA hsa-miR-330-3p COL6A3 0.876747334239085 0.00073709016089703 -1.49732720873756 0.000705770797494499 miRNATAP -0.632385715219901 2.95499049604057e-15 NA NA NA hsa-miR-362-3p COL6A3 2.0756816987665 3.89026064579331e-12 -1.49732720873756 0.000705770797494499 miRanda -0.194943888306204 0.00721955815029335 NA NA NA hsa-miR-429 COL6A3 4.48815175680773 2.44117492218206e-17 -1.49732720873756 0.000705770797494499 miRNATAP -0.382525267453802 1.91833135798669e-25 NA NA NA hsa-miR-590-3p COL6A3 2.59289455139753 1.03200520972022e-21 -1.49732720873756 0.000705770797494499 miRanda -0.52809690636908 3.52708257722657e-12 NA NA NA hsa-miR-877-5p COL6A3 2.94916202082736 1.8151927276044e-13 -1.49732720873756 0.000705770797494499 MirTarget;miRNATAP -0.455392334335153 1.14050165872702e-15 NA NA NA hsa-miR-29c-3p COL7A1 -0.00968972577705429 0.97099586346872 2.35263703598149 4.83141912604635e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.333823327776589 0.000106305726472686 NA NA NA hsa-miR-106a-5p COL8A2 2.48882002962836 1.99757727374521e-12 -1.27039967006167 0.00295078611440585 mirMAP -0.442195274961458 1.21230235770643e-15 NA NA NA hsa-miR-106b-5p COL8A2 2.46782146831112 1.36171495805632e-23 -1.27039967006167 0.00295078611440585 mirMAP -0.831641017656662 1.01387852606909e-28 NA NA NA hsa-miR-17-5p COL8A2 3.2710598467455 9.93128340539455e-27 -1.27039967006167 0.00295078611440585 mirMAP -0.581617159195874 1.02256466134908e-21 NA NA NA hsa-miR-185-5p COL8A2 2.34016206907488 1.17481626642022e-26 -1.27039967006167 0.00295078611440585 mirMAP -0.698114137398135 7.40294847462155e-16 NA NA NA hsa-miR-197-3p COL8A2 1.75733174019505 8.88576793100499e-13 -1.27039967006167 0.00295078611440585 mirMAP -0.550962886222063 8.2436045099866e-12 NA NA NA hsa-miR-20a-5p COL8A2 3.15577933619191 4.19753346442454e-25 -1.27039967006167 0.00295078611440585 mirMAP -0.58579978752016 9.6420351721792e-22 NA NA NA hsa-miR-20b-5p COL8A2 2.07706563022469 1.10107236083433e-05 -1.27039967006167 0.00295078611440585 mirMAP -0.294040223732093 4.11960610228254e-12 NA NA NA hsa-miR-3127-5p COL8A2 1.51846438737133 3.59571251672767e-07 -1.27039967006167 0.00295078611440585 MirTarget -0.587799293850679 5.01770050894695e-19 NA NA NA hsa-miR-335-5p COL8A2 1.77247705492746 2.22457658872091e-06 -1.27039967006167 0.00295078611440585 miRNAWalker2_validate -0.279665112831492 2.41304950249939e-07 NA NA NA hsa-miR-361-3p COL8A2 1.07367425434318 1.73142774168958e-09 -1.27039967006167 0.00295078611440585 MirTarget;mirMAP -0.482250976326787 2.77582630682159e-05 NA NA NA hsa-miR-3614-5p COL8A2 2.17736331059655 2.19144831318484e-08 -1.27039967006167 0.00295078611440585 MirTarget;miRNATAP -0.230470947249633 1.96924854724113e-05 NA NA NA hsa-miR-582-5p COL8A2 0.609226359812689 0.032988717891497 -1.27039967006167 0.00295078611440585 PITA -0.560575324123187 1.74286867396086e-15 NA NA NA hsa-miR-592 COL8A2 1.51765968871077 0.000636335248013204 -1.27039967006167 0.00295078611440585 MirTarget;PITA;miRNATAP -0.329472617451126 9.30226915826346e-13 NA NA NA hsa-miR-625-5p COL8A2 1.42540152147292 1.95797147911206e-06 -1.27039967006167 0.00295078611440585 MirTarget -0.322589472764854 1.66626292768879e-05 NA NA NA hsa-miR-26b-5p CRLF1 0.885393662798425 3.2116297961629e-06 -1.79916901862297 0.0013463629734276 miRNAWalker2_validate -0.516303793111274 0.00031075916002893 NA NA NA hsa-miR-125a-3p CTGF 1.24490295132072 5.26925231010328e-06 -3.1646965721889 1.41660027051818e-12 PITA;miRanda -0.276496084105092 0.000607804236051295 NA NA NA hsa-miR-149-5p CTGF 2.94200492826326 4.93436498919036e-14 -3.1646965721889 1.41660027051818e-12 miRNATAP -0.380687798802941 1.46739217650299e-12 NA NA NA hsa-miR-16-2-3p CTGF 2.31623086727196 4.29838149388188e-20 -3.1646965721889 1.41660027051818e-12 MirTarget -0.742986683852501 3.48492935917027e-20 NA NA NA hsa-miR-18a-5p CTGF 3.78535678765353 3.72446596213886e-26 -3.1646965721889 1.41660027051818e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.521933840391543 1.25436249823488e-18 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-19a-3p CTGF 3.42309334186656 3.02671914353412e-28 -3.1646965721889 1.41660027051818e-12 MirTarget;miRNATAP -0.625421227845991 7.9297931677912e-23 NA NA NA hsa-miR-19b-3p CTGF 2.49529833021187 1.57028265846699e-23 -3.1646965721889 1.41660027051818e-12 MirTarget;miRNATAP -0.844188161775728 2.92266131554751e-26 NA NA NA hsa-miR-205-5p CTGF 4.1389800495524 2.05488295686453e-12 -3.1646965721889 1.41660027051818e-12 miRNAWalker2_validate;miRTarBase -0.333299257318783 1.37204454674649e-21 NA NA NA hsa-miR-26b-3p CTGF 2.18464160365372 2.11543189388328e-18 -3.1646965721889 1.41660027051818e-12 MirTarget;miRNATAP -0.817366139085892 7.75317684169854e-24 25761878 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1 sarcoma hsa-miR-26b-5p CTGF 0.885393662798425 3.2116297961629e-06 -3.1646965721889 1.41660027051818e-12 miRNATAP -0.68880035662657 2.17929453702755e-09 25761878 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1 sarcoma hsa-miR-3065-5p CTGF 2.74629919868982 1.86846589298284e-08 -3.1646965721889 1.41660027051818e-12 MirTarget;miRNATAP -0.321653443593315 2.49547811909434e-09 NA NA NA hsa-miR-330-3p CTGF 0.876747334239085 0.00073709016089703 -3.1646965721889 1.41660027051818e-12 MirTarget;PITA;miRNATAP -0.642502576701344 9.52940442652617e-15 NA NA NA hsa-miR-361-3p CTGF 1.07367425434318 1.73142774168958e-09 -3.1646965721889 1.41660027051818e-12 MirTarget;miRNATAP -0.462885035697563 0.000178540398596777 NA NA NA hsa-miR-375 CTGF 1.13910305294079 0.0512283522214186 -3.1646965721889 1.41660027051818e-12 miRNAWalker2_validate;miRanda -0.190568830223966 3.79777279474255e-07 NA NA NA hsa-miR-486-5p CTGF -0.194913133034028 0.607377798807705 -3.1646965721889 1.41660027051818e-12 miRanda -0.175746805388009 0.00272179996711368 NA NA NA hsa-miR-590-3p CTGF 2.59289455139753 1.03200520972022e-21 -3.1646965721889 1.41660027051818e-12 PITA;miRanda -0.688502163944404 4.25058637698374e-19 NA NA NA hsa-miR-7-1-3p CTGF 1.84950311431067 1.25300363397654e-13 -3.1646965721889 1.41660027051818e-12 MirTarget -0.653785189114178 8.24683254904366e-15 NA NA NA hsa-miR-148b-3p CTHRC1 1.97815018171325 6.07715327281595e-26 0.841508523877378 0.10163164303971 miRNAWalker2_validate -0.938096862021733 1.59235945220759e-14 NA NA NA hsa-miR-30b-5p CTHRC1 0.800822374912712 0.000133601914525413 0.841508523877378 0.10163164303971 MirTarget -0.783893218218859 1.59051808797798e-11 26388700 MiR-30b was down-regulated and Cthrc1 up-regulated in NSCLC tissues; Bioinformatics analysis identified Cthrc1 as a target of miR-30b and western blotting and luciferase reporter assays confirmed that miR-30b regulates Cthrc1 by directly binding to its 3'UTR; Transfection of Cthrc1 without the 3'UTR restored the miR-30b inhibiting cell invasion; Up-regulation of miR-30b or down-regulation of Cthrc1 had potential significance in the invasion and metastasis of NSCLC; MiR-30b was down-regulated and Cthrc1 up-regulated in NSCLC tissues; MiR-30b affected NSCLC cells invasion and migration by regulating Cthrc1 metastasis lung squamous cell cancer hsa-miR-30c-5p CTHRC1 0.778774633108 0.000285599212429136 0.841508523877378 0.10163164303971 MirTarget -0.910848077788078 5.01378815693279e-16 NA NA NA hsa-miR-30d-5p CTHRC1 0.675423997639582 0.00270618816039773 0.841508523877378 0.10163164303971 MirTarget -1.19240424605801 6.22115995636136e-31 NA NA NA hsa-miR-30e-5p CTHRC1 1.23904909539663 1.35561917122157e-09 0.841508523877378 0.10163164303971 MirTarget -1.30709080535696 1.44240282011599e-31 NA NA NA hsa-miR-335-3p CTHRC1 3.08791651139852 5.31309869723517e-12 0.841508523877378 0.10163164303971 MirTarget -0.17908291607752 0.000902913502704944 NA NA NA hsa-miR-335-5p CTHRC1 1.77247705492746 2.22457658872091e-06 0.841508523877378 0.10163164303971 miRNAWalker2_validate -0.208314997832729 0.00148387342595615 NA NA NA hsa-miR-3607-3p CTHRC1 2.68532138541128 5.66716351955047e-14 0.841508523877378 0.10163164303971 MirTarget;miRNATAP -0.348894444431505 3.69373155760552e-07 NA NA NA hsa-miR-421 CTHRC1 1.17791565395543 6.78526676976629e-06 0.841508523877378 0.10163164303971 miRanda -0.32389707013397 0.000607663984366222 NA NA NA hsa-miR-590-3p CTHRC1 2.59289455139753 1.03200520972022e-21 0.841508523877378 0.10163164303971 miRanda -0.251820577313563 0.00512743545901313 NA NA NA hsa-miR-101-3p CXCL12 0.522819989585461 0.00375627731618038 -3.25514460573678 2.71023256513876e-11 miRNATAP -0.542089931746858 5.99675986851919e-05 26349988;27693460 miR 101 represses lung cancer by inhibiting interaction of fibroblasts and cancer cells by down regulating CXCL12; We examined several putative miR-101 target genes identified by microarray analysis and demonstrated that miR-101 directly targets CXCL12 which play important roles in CAFs; Further research showed that the cellular biological behavior was regulated by miR-101 targeting CXCL12; These findings provide new insights miR-101 down-regulation in CAFs could inhibit lung cancer proliferation and metastasis via targeting CXCL12;Vascular mimicry formation is promoted by paracrine TGF β and SDF1 of cancer associated fibroblasts and inhibited by miR 101 in hepatocellular carcinoma metastasis; lung cancer;liver cancer hsa-miR-126-3p CXCL12 1.6384689127743 1.4473425456641e-10 -3.25514460573678 2.71023256513876e-11 miRNAWalker2_validate -0.270451938229554 0.00367088399794659 NA NA NA hsa-miR-141-3p CXCL12 5.02396127982626 2.19224509139725e-24 -3.25514460573678 2.71023256513876e-11 miRNATAP -0.581600485846245 1.98789449461909e-44 NA NA NA hsa-miR-144-3p CXCL12 0.658119849508907 0.146943823997989 -3.25514460573678 2.71023256513876e-11 miRNATAP -0.241701797351171 9.93410183317339e-06 NA NA NA hsa-miR-16-2-3p CXCL12 2.31623086727196 4.29838149388188e-20 -3.25514460573678 2.71023256513876e-11 mirMAP -0.716801089851176 8.07618251687436e-16 NA NA NA hsa-miR-186-5p CXCL12 1.47445398888668 3.0781726595413e-15 -3.25514460573678 2.71023256513876e-11 mirMAP -0.894307732920121 4.34658490419176e-13 NA NA NA hsa-miR-200a-3p CXCL12 4.59434485520731 6.38952518573476e-18 -3.25514460573678 2.71023256513876e-11 miRNATAP -0.496563162119286 2.6197531805871e-35 NA NA NA hsa-miR-23a-3p CXCL12 1.00493340843378 2.55313889288924e-08 -3.25514460573678 2.71023256513876e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.665913217473937 5.04733396178919e-07 25322765 MiR-23a suppressed the transcription of RUNX2 and CXCL12 by binding to the 3' UTRs of these mRNAs; The cellular function of miR-23a is RUNX2/CXCL12-dependent and the overexpression of RUNX2 or CXCL12 rescued the impaired cell growth migration and invasion induced by miR-23a sarcoma hsa-miR-301a-3p CXCL12 2.81024345929638 2.29784847962242e-17 -3.25514460573678 2.71023256513876e-11 miRNATAP -0.637210556417471 3.89512282408225e-19 NA NA NA hsa-miR-30b-5p CXCL12 0.800822374912712 0.000133601914525413 -3.25514460573678 2.71023256513876e-11 mirMAP -0.662406837733533 6.35934019235512e-09 NA NA NA hsa-miR-30c-5p CXCL12 0.778774633108 0.000285599212429136 -3.25514460573678 2.71023256513876e-11 mirMAP -0.726597552455617 5.54263956743282e-11 NA NA NA hsa-miR-30d-5p CXCL12 0.675423997639582 0.00270618816039773 -3.25514460573678 2.71023256513876e-11 mirMAP -0.929109047803243 2.80390033189822e-19 NA NA NA hsa-miR-31-5p CXCL12 3.59165123035072 2.27423212057482e-07 -3.25514460573678 2.71023256513876e-11 miRNAWalker2_validate -0.245986962195924 4.96339078564571e-12 NA NA NA hsa-miR-320a CXCL12 0.438165828017084 0.0390159073347133 -3.25514460573678 2.71023256513876e-11 miRanda -0.91239452561972 2.1887628621058e-16 NA NA NA hsa-miR-320b CXCL12 1.55692969039548 1.41071034251915e-08 -3.25514460573678 2.71023256513876e-11 miRanda -0.883291306712167 3.2426875813925e-27 NA NA NA hsa-miR-328-3p CXCL12 0.596804159297544 0.013858523511843 -3.25514460573678 2.71023256513876e-11 MirTarget -0.451394365373253 5.76677839859184e-06 NA NA NA hsa-miR-375 CXCL12 1.13910305294079 0.0512283522214186 -3.25514460573678 2.71023256513876e-11 PITA;miRanda -0.168576191123304 4.13014098549281e-05 NA NA NA hsa-miR-429 CXCL12 4.48815175680773 2.44117492218206e-17 -3.25514460573678 2.71023256513876e-11 miRanda;miRNATAP -0.4784910637442 5.81975116042708e-32 NA NA NA hsa-miR-455-5p CXCL12 2.2582442061694 1.43472128037398e-13 -3.25514460573678 2.71023256513876e-11 miRanda -0.286668694928783 0.000190621446275961 NA NA NA hsa-miR-532-5p CXCL12 1.55697650978597 1.57884735535196e-11 -3.25514460573678 2.71023256513876e-11 PITA;miRNATAP -0.43238470306589 2.40580716962007e-05 NA NA NA hsa-miR-590-3p CXCL12 2.59289455139753 1.03200520972022e-21 -3.25514460573678 2.71023256513876e-11 PITA;miRanda;mirMAP -0.607139014614312 1.21612536925607e-12 NA NA NA hsa-miR-625-5p CXCL12 1.42540152147292 1.95797147911206e-06 -3.25514460573678 2.71023256513876e-11 MirTarget -0.299035245447517 0.000663541164794402 NA NA NA hsa-miR-629-3p CXCL12 2.36570947321815 1.33458201201618e-11 -3.25514460573678 2.71023256513876e-11 MirTarget -0.36946142364118 1.09216965219414e-06 NA NA NA hsa-miR-96-5p CXCL12 4.89433085814374 1.92000659886961e-31 -3.25514460573678 2.71023256513876e-11 mirMAP -0.567460708912908 2.5868024129957e-28 NA NA NA hsa-miR-361-5p CXCL6 0.971859117235239 5.30236555707088e-09 0.728104459555756 0.299217544148774 miRanda -0.598394224484802 0.00324425516283997 NA NA NA hsa-miR-93-5p CXCL6 3.03961860136032 1.11672209617395e-24 0.728104459555756 0.299217544148774 MirTarget -0.326346975078183 0.00251720441259585 NA NA NA hsa-miR-181a-5p CYR61 2.29556023480783 1.8138457900616e-21 -3.31998821363408 1.89050487970015e-17 miRNATAP -0.263794858025289 0.00069411585625249 NA NA NA hsa-miR-181b-5p CYR61 2.49307679431293 3.92829250217627e-20 -3.31998821363408 1.89050487970015e-17 miRNATAP -0.304950847308246 9.71632715178792e-06 NA NA NA hsa-miR-181c-5p CYR61 1.58587920618301 1.57506918816933e-10 -3.31998821363408 1.89050487970015e-17 miRNATAP -0.332005634078617 1.85820996135703e-05 NA NA NA hsa-miR-205-5p CYR61 4.1389800495524 2.05488295686453e-12 -3.31998821363408 1.89050487970015e-17 miRNAWalker2_validate;miRTarBase -0.2893454260322 9.65983479986671e-21 NA NA NA hsa-miR-26b-5p CYR61 0.885393662798425 3.2116297961629e-06 -3.31998821363408 1.89050487970015e-17 miRNAWalker2_validate -0.531198483165112 2.14624252836147e-07 NA NA NA hsa-miR-32-3p CYR61 2.02436999565685 5.94091197945307e-09 -3.31998821363408 1.89050487970015e-17 miRNATAP -0.479139853796883 6.67781363536209e-15 NA NA NA hsa-miR-331-5p CYR61 2.17414714166315 1.54547681391888e-18 -3.31998821363408 1.89050487970015e-17 miRNATAP -0.66992581933852 6.9510018689482e-19 NA NA NA hsa-miR-429 CYR61 4.48815175680773 2.44117492218206e-17 -3.31998821363408 1.89050487970015e-17 miRanda -0.39006558154442 3.08983227690959e-32 NA NA NA hsa-miR-944 CYR61 2.91186649218281 1.31574753528144e-06 -3.31998821363408 1.89050487970015e-17 PITA;mirMAP;miRNATAP -0.29570612507135 1.4300634733975e-20 NA NA NA hsa-miR-106a-5p DAB2 2.48882002962836 1.99757727374521e-12 -0.691299391910039 0.0326535251444597 MirTarget;miRNATAP -0.129672192096929 0.00261308308798802 NA NA NA hsa-miR-106b-5p DAB2 2.46782146831112 1.36171495805632e-23 -0.691299391910039 0.0326535251444597 MirTarget;miRNATAP -0.378814268771787 1.58664613770872e-10 26769181 The expression of the miR-106b target gene DAB2 in human cervical tissues and cell lines were measured by qRT-PCR western blot and immunohistochemistry; DAB2 a predicted target gene of miR-106b was inhibited by TGF-β1 partly through miR-106b and was involved in TGF-β1-induced cervical cancer cell migration; The expression of DAB2 was low in cervical cancer tissues and negatively correlated with miR-106b expression cell migration cervical and endocervical cancer hsa-miR-1271-5p DAB2 0.970418832993172 0.000609742584380688 -0.691299391910039 0.0326535251444597 MirTarget -0.15715313947503 0.00451416238627398 NA NA NA hsa-miR-129-5p DAB2 -0.524170159980738 0.222582956006346 -0.691299391910039 0.0326535251444597 MirTarget;miRanda -0.135750883154893 0.000249131759162275 NA NA NA hsa-miR-149-5p DAB2 2.94200492826326 4.93436498919036e-14 -0.691299391910039 0.0326535251444597 miRNATAP -0.139064846989816 0.000332067162099391 NA NA NA hsa-miR-17-5p DAB2 3.2710598467455 9.93128340539455e-27 -0.691299391910039 0.0326535251444597 MirTarget;TargetScan;miRNATAP -0.316926831129393 1.73038588021749e-11 NA NA NA hsa-miR-186-5p DAB2 1.47445398888668 3.0781726595413e-15 -0.691299391910039 0.0326535251444597 MirTarget;mirMAP -0.269139137453688 0.00100152187125024 NA NA NA hsa-miR-203a-3p DAB2 3.12352008343999 9.49391438647189e-07 -0.691299391910039 0.0326535251444597 MirTarget -0.15451020437247 7.44267518184335e-11 NA NA NA hsa-miR-20a-5p DAB2 3.15577933619191 4.19753346442454e-25 -0.691299391910039 0.0326535251444597 MirTarget;miRNATAP -0.311326983050197 5.52243241881671e-11 NA NA NA hsa-miR-26b-5p DAB2 0.885393662798425 3.2116297961629e-06 -0.691299391910039 0.0326535251444597 miRNAWalker2_validate -0.368640152029956 6.72342462079521e-06 NA NA NA hsa-miR-320a DAB2 0.438165828017084 0.0390159073347133 -0.691299391910039 0.0326535251444597 PITA;miRanda;miRNATAP -0.370382691097417 4.91209687406498e-07 NA NA NA hsa-miR-320b DAB2 1.55692969039548 1.41071034251915e-08 -0.691299391910039 0.0326535251444597 PITA;miRanda;miRNATAP -0.337023295642442 1.12902794071141e-09 NA NA NA hsa-miR-330-5p DAB2 1.15100069700871 4.85551805046014e-07 -0.691299391910039 0.0326535251444597 miRanda -0.228593256222459 0.000764439556242791 NA NA NA hsa-miR-331-5p DAB2 2.17414714166315 1.54547681391888e-18 -0.691299391910039 0.0326535251444597 PITA -0.297665436673973 1.63062754901281e-06 NA NA NA hsa-miR-335-5p DAB2 1.77247705492746 2.22457658872091e-06 -0.691299391910039 0.0326535251444597 miRNAWalker2_validate;miRNATAP -0.147474014256986 0.000347024362610948 NA NA NA hsa-miR-532-3p DAB2 1.96631878320218 4.53421954361695e-13 -0.691299391910039 0.0326535251444597 PITA -0.164417652996565 0.00344320957608891 NA NA NA hsa-miR-590-3p DAB2 2.59289455139753 1.03200520972022e-21 -0.691299391910039 0.0326535251444597 miRanda;mirMAP -0.193489148580734 0.000621227462459594 NA NA NA hsa-miR-590-5p DAB2 3.18300989862077 2.06813568597893e-26 -0.691299391910039 0.0326535251444597 miRanda -0.206114937689243 4.19901273570571e-05 NA NA NA hsa-miR-93-5p DAB2 3.03961860136032 1.11672209617395e-24 -0.691299391910039 0.0326535251444597 MirTarget;miRNATAP -0.289301294187389 3.98934666674643e-09 24037530 miR 93 directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer; We next identify that microRNA miR-93 functions as a potent repressor of DAB2 expression by directly targeting the 3'UTR of the DAB2 mRNA; Using in vitro and in vivo approaches we demonstrate that miR-93 overexpression has an important role in promoting lung cancer cell growth and that its oncogenic function is primarily mediated by downregulating DAB2 expression; The correlations of both low DAB2 and high miR-93 expression levels with poor patient survival strongly support the critical role of the miR-93/DAB2 pathway in determining lung cancer progression progression;poor survival lung cancer hsa-miR-96-5p DAB2 4.89433085814374 1.92000659886961e-31 -0.691299391910039 0.0326535251444597 MirTarget;TargetScan -0.258429175765528 7.18767748775505e-14 NA NA NA hsa-let-7a-5p DCN 0.618599506841644 2.76973453058748e-05 -3.45334496072418 3.0714283501425e-12 MirTarget -1.29955949028783 2.15054923683201e-15 NA NA NA hsa-let-7b-5p DCN 0.604314269683977 0.00140009936153214 -3.45334496072418 3.0714283501425e-12 MirTarget -0.735312761308106 1.28325169508081e-08 NA NA NA hsa-let-7d-5p DCN 1.33236798905207 1.1741085658466e-13 -3.45334496072418 3.0714283501425e-12 MirTarget -1.30966003831062 8.0468390056938e-25 NA NA NA hsa-let-7e-5p DCN 0.860104282510173 6.04758298373779e-05 -3.45334496072418 3.0714283501425e-12 MirTarget -0.607888949600183 8.40952632374267e-08 NA NA NA hsa-let-7f-5p DCN 0.495648727272215 0.00355972741198794 -3.45334496072418 3.0714283501425e-12 MirTarget -0.721094649237192 6.80885340057416e-07 NA NA NA hsa-let-7g-5p DCN 1.20061455355116 1.50237505511483e-12 -3.45334496072418 3.0714283501425e-12 MirTarget -1.36880417070961 6.35488108564248e-24 NA NA NA hsa-miR-181a-5p DCN 2.29556023480783 1.8138457900616e-21 -3.45334496072418 3.0714283501425e-12 MirTarget -0.506710171322978 1.45285801866355e-07 NA NA NA hsa-miR-181b-5p DCN 2.49307679431293 3.92829250217627e-20 -3.45334496072418 3.0714283501425e-12 MirTarget -0.578145379067561 9.73053510952451e-12 NA NA NA hsa-miR-181c-5p DCN 1.58587920618301 1.57506918816933e-10 -3.45334496072418 3.0714283501425e-12 MirTarget -0.503303068283161 1.83070019040477e-07 NA NA NA hsa-miR-181d-5p DCN 1.52204912185579 9.2693319057748e-08 -3.45334496072418 3.0714283501425e-12 MirTarget -0.482885764181953 9.60777067016379e-09 NA NA NA hsa-miR-186-5p DCN 1.47445398888668 3.0781726595413e-15 -3.45334496072418 3.0714283501425e-12 mirMAP -1.22695905339932 8.08140032867963e-24 NA NA NA hsa-miR-3065-5p DCN 2.74629919868982 1.86846589298284e-08 -3.45334496072418 3.0714283501425e-12 mirMAP -0.299460625015316 6.3090350551147e-07 NA NA NA hsa-miR-320a DCN 0.438165828017084 0.0390159073347133 -3.45334496072418 3.0714283501425e-12 miRanda -0.885017857237456 5.63097559308097e-15 NA NA NA hsa-miR-320b DCN 1.55692969039548 1.41071034251915e-08 -3.45334496072418 3.0714283501425e-12 miRanda -0.868290115344502 2.31348822218025e-25 NA NA NA hsa-miR-374b-3p DCN 0.930487774873495 2.74420094310516e-05 -3.45334496072418 3.0714283501425e-12 MirTarget -0.599882155684483 4.65687659545439e-08 NA NA NA hsa-miR-421 DCN 1.17791565395543 6.78526676976629e-06 -3.45334496072418 3.0714283501425e-12 miRanda -0.712973490983918 4.07124694193684e-15 NA NA NA hsa-miR-491-5p DCN 0.615770352820862 0.0418295628761654 -3.45334496072418 3.0714283501425e-12 miRanda -0.484525900445249 1.866547904204e-08 NA NA NA hsa-miR-501-5p DCN 1.93654809410041 1.3779381780759e-10 -3.45334496072418 3.0714283501425e-12 mirMAP -0.487796424451936 1.69817707392228e-09 NA NA NA hsa-miR-590-3p DCN 2.59289455139753 1.03200520972022e-21 -3.45334496072418 3.0714283501425e-12 MirTarget;PITA;miRanda;mirMAP -0.809280815704104 1.40193401668637e-21 NA NA NA hsa-miR-7-1-3p DCN 1.84950311431067 1.25300363397654e-13 -3.45334496072418 3.0714283501425e-12 mirMAP -0.819180541083217 6.65494529445234e-19 NA NA NA hsa-miR-944 DCN 2.91186649218281 1.31574753528144e-06 -3.45334496072418 3.0714283501425e-12 mirMAP -0.316956220240754 4.00458729865207e-15 NA NA NA hsa-miR-98-5p DCN 1.11154309866014 1.24143909012085e-08 -3.45334496072418 3.0714283501425e-12 MirTarget -1.02545685526001 1.91396489138775e-17 NA NA NA hsa-let-7a-5p DPYSL3 0.618599506841644 2.76973453058748e-05 -2.3174606683978 1.31913973979472e-07 TargetScan -1.00168868670414 4.63649309878784e-12 NA NA NA hsa-miR-107 DPYSL3 1.30977326593435 1.30372468603965e-11 -2.3174606683978 1.31913973979472e-07 miRanda -1.0862948552257 9.95099043653015e-26 NA NA NA hsa-miR-125a-5p DPYSL3 0.599529391575274 0.0102300147180307 -2.3174606683978 1.31913973979472e-07 miRanda -0.499171360649967 5.04384910551149e-08 NA NA NA hsa-miR-1266-5p DPYSL3 1.3763848124288 0.000876906064212958 -2.3174606683978 1.31913973979472e-07 MirTarget -0.407154198809396 6.89739314059287e-16 NA NA NA hsa-miR-141-3p DPYSL3 5.02396127982626 2.19224509139725e-24 -2.3174606683978 1.31913973979472e-07 TargetScan -0.538946381354509 4.38482185108261e-49 NA NA NA hsa-miR-141-5p DPYSL3 3.81419396518882 3.21977359736126e-18 -2.3174606683978 1.31913973979472e-07 MirTarget -0.574693885955341 2.48269447930143e-41 NA NA NA hsa-miR-197-3p DPYSL3 1.75733174019505 8.88576793100499e-13 -2.3174606683978 1.31913973979472e-07 miRNAWalker2_validate -0.701802112595395 1.89003641606185e-17 NA NA NA hsa-miR-22-3p DPYSL3 1.21545661147757 1.61670170137775e-13 -2.3174606683978 1.31913973979472e-07 miRNATAP -0.404606180737998 0.00171478661253739 NA NA NA hsa-miR-25-3p DPYSL3 1.36472605225697 4.83790725935681e-11 -2.3174606683978 1.31913973979472e-07 mirMAP -0.796903550270341 8.7592805911389e-16 NA NA NA hsa-miR-26a-2-3p DPYSL3 0.823520019989974 0.00017092160823769 -2.3174606683978 1.31913973979472e-07 mirMAP -0.287367529395716 0.00375065222006426 NA NA NA hsa-miR-26b-5p DPYSL3 0.885393662798425 3.2116297961629e-06 -2.3174606683978 1.31913973979472e-07 miRNAWalker2_validate -0.858648611138247 6.15567018026338e-15 NA NA NA hsa-miR-29b-3p DPYSL3 1.65828197923813 1.02676780888141e-09 -2.3174606683978 1.31913973979472e-07 MirTarget -0.593766069186813 4.31720482291662e-15 NA NA NA hsa-miR-29c-3p DPYSL3 -0.00968972577705429 0.97099586346872 -2.3174606683978 1.31913973979472e-07 MirTarget -0.493199374407555 6.90676466821937e-10 NA NA NA hsa-miR-31-3p DPYSL3 2.70807981248858 8.84479434501203e-05 -2.3174606683978 1.31913973979472e-07 MirTarget -0.165714377569189 9.18502305404193e-07 NA NA NA hsa-miR-320a DPYSL3 0.438165828017084 0.0390159073347133 -2.3174606683978 1.31913973979472e-07 miRNATAP -0.798531519383534 7.51732515537867e-16 NA NA NA hsa-miR-320b DPYSL3 1.55692969039548 1.41071034251915e-08 -2.3174606683978 1.31913973979472e-07 miRNATAP -0.696768756788013 4.33298583007831e-21 NA NA NA hsa-miR-324-3p DPYSL3 2.08739139768981 3.11885987067952e-13 -2.3174606683978 1.31913973979472e-07 PITA -0.714257217023633 6.26386341814903e-25 NA NA NA hsa-miR-330-3p DPYSL3 0.876747334239085 0.00073709016089703 -2.3174606683978 1.31913973979472e-07 MirTarget;PITA;miRNATAP -0.736437545930441 1.55177443989057e-20 NA NA NA hsa-miR-335-3p DPYSL3 3.08791651139852 5.31309869723517e-12 -2.3174606683978 1.31913973979472e-07 mirMAP -0.305518988453923 2.7421145763429e-11 NA NA NA hsa-miR-362-3p DPYSL3 2.0756816987665 3.89026064579331e-12 -2.3174606683978 1.31913973979472e-07 PITA;miRanda;miRNATAP -0.375329055178215 1.81905765933322e-07 NA NA NA hsa-miR-375 DPYSL3 1.13910305294079 0.0512283522214186 -2.3174606683978 1.31913973979472e-07 miRNAWalker2_validate -0.114873300302772 0.00177441588646283 NA NA NA hsa-miR-423-3p DPYSL3 2.57855385753676 9.19765570228097e-24 -2.3174606683978 1.31913973979472e-07 miRNAWalker2_validate -0.888725388143964 1.73810344103641e-33 NA NA NA hsa-miR-450b-5p DPYSL3 1.69244418548325 1.68064054148881e-10 -2.3174606683978 1.31913973979472e-07 mirMAP -0.304164975898453 0.000133256607153225 NA NA NA hsa-miR-532-3p DPYSL3 1.96631878320218 4.53421954361695e-13 -2.3174606683978 1.31913973979472e-07 miRNATAP -0.752083572964367 8.36540970582367e-25 NA NA NA hsa-miR-589-5p DPYSL3 1.71990116752371 8.310889042056e-14 -2.3174606683978 1.31913973979472e-07 mirMAP -0.678461566687691 2.02150049421193e-14 NA NA NA hsa-miR-590-3p DPYSL3 2.59289455139753 1.03200520972022e-21 -2.3174606683978 1.31913973979472e-07 miRanda;mirMAP -0.649905173824145 4.53521835206121e-18 NA NA NA hsa-let-7g-5p DST 1.20061455355116 1.50237505511483e-12 -1.11542714896545 9.14769438027749e-05 miRNATAP -0.411403591839884 2.70349643973748e-07 NA NA NA hsa-miR-101-3p DST 0.522819989585461 0.00375627731618038 -1.11542714896545 9.14769438027749e-05 mirMAP -0.253773806125156 0.00108840859982944 NA NA NA hsa-miR-106a-5p DST 2.48882002962836 1.99757727374521e-12 -1.11542714896545 9.14769438027749e-05 mirMAP -0.202238442762636 8.45798188267172e-08 NA NA NA hsa-miR-106b-5p DST 2.46782146831112 1.36171495805632e-23 -1.11542714896545 9.14769438027749e-05 mirMAP -0.359360903799886 6.3956724573264e-12 NA NA NA hsa-miR-125a-5p DST 0.599529391575274 0.0102300147180307 -1.11542714896545 9.14769438027749e-05 mirMAP -0.169880804036748 0.0044601861348643 NA NA NA hsa-miR-126-5p DST 0.895338176458417 2.33372756450713e-05 -1.11542714896545 9.14769438027749e-05 mirMAP -0.221451304213013 0.000720178288356143 NA NA NA hsa-miR-130b-5p DST 2.9963110846538 1.98883029416455e-18 -1.11542714896545 9.14769438027749e-05 mirMAP -0.249462549968581 2.04112573028429e-10 NA NA NA hsa-miR-140-5p DST 0.844753502512594 3.73722278438606e-05 -1.11542714896545 9.14769438027749e-05 mirMAP -0.203045598802249 0.00276354246728312 NA NA NA hsa-miR-141-3p DST 5.02396127982626 2.19224509139725e-24 -1.11542714896545 9.14769438027749e-05 mirMAP -0.122503310762156 3.24347958325919e-06 NA NA NA hsa-miR-149-5p DST 2.94200492826326 4.93436498919036e-14 -1.11542714896545 9.14769438027749e-05 mirMAP -0.107513877924324 0.00178275470973944 NA NA NA hsa-miR-15b-3p DST 2.33847028227712 4.29662877950836e-19 -1.11542714896545 9.14769438027749e-05 mirMAP -0.230197443714883 5.24069297012441e-06 NA NA NA hsa-miR-16-1-3p DST 2.56983217111073 3.02262181237943e-20 -1.11542714896545 9.14769438027749e-05 mirMAP -0.232167858858386 1.72522293275347e-06 NA NA NA hsa-miR-16-2-3p DST 2.31623086727196 4.29838149388188e-20 -1.11542714896545 9.14769438027749e-05 mirMAP -0.239882773354863 4.59347816996849e-06 NA NA NA hsa-miR-17-3p DST 2.2704817679209 1.1667437320211e-22 -1.11542714896545 9.14769438027749e-05 mirMAP;miRNATAP -0.308532447295898 4.48443194425218e-08 NA NA NA hsa-miR-17-5p DST 3.2710598467455 9.93128340539455e-27 -1.11542714896545 9.14769438027749e-05 mirMAP -0.244580232081797 5.9760387617914e-09 NA NA NA hsa-miR-183-5p DST 4.19757025992371 4.79612296318304e-26 -1.11542714896545 9.14769438027749e-05 mirMAP -0.167522012465535 2.39884850000645e-07 NA NA NA hsa-miR-186-5p DST 1.47445398888668 3.0781726595413e-15 -1.11542714896545 9.14769438027749e-05 mirMAP -0.466353033771707 5.62365768144053e-11 NA NA NA hsa-miR-18a-5p DST 3.78535678765353 3.72446596213886e-26 -1.11542714896545 9.14769438027749e-05 mirMAP -0.198742361138772 1.85098897590889e-07 NA NA NA hsa-miR-192-5p DST 2.69002528723195 1.22990188194432e-16 -1.11542714896545 9.14769438027749e-05 miRNAWalker2_validate;mirMAP -0.296185440062108 1.48389172051409e-13 NA NA NA hsa-miR-19b-1-5p DST 2.57951428759379 4.31576118703427e-20 -1.11542714896545 9.14769438027749e-05 mirMAP -0.241262886672642 5.29309184916582e-07 NA NA NA hsa-miR-200a-3p DST 4.59434485520731 6.38952518573476e-18 -1.11542714896545 9.14769438027749e-05 mirMAP -0.145356519285992 3.28603013312216e-09 NA NA NA hsa-miR-200b-3p DST 3.78235093249346 3.18343003239465e-14 -1.11542714896545 9.14769438027749e-05 mirMAP -0.142859509529446 8.00720790906233e-08 NA NA NA hsa-miR-200c-3p DST 3.50132673580082 2.42716349086937e-15 -1.11542714896545 9.14769438027749e-05 mirMAP -0.104545025716321 0.000541561844338111 NA NA NA hsa-miR-20a-3p DST 2.92621109947706 2.49504904635375e-17 -1.11542714896545 9.14769438027749e-05 mirMAP -0.159689438041232 5.29801955916423e-05 NA NA NA hsa-miR-20a-5p DST 3.15577933619191 4.19753346442454e-25 -1.11542714896545 9.14769438027749e-05 mirMAP -0.254276549684316 1.78150130995562e-09 NA NA NA hsa-miR-20b-5p DST 2.07706563022469 1.10107236083433e-05 -1.11542714896545 9.14769438027749e-05 mirMAP -0.205515344963446 3.8960682682119e-13 NA NA NA hsa-miR-215-5p DST 2.30755467422978 2.38476032118039e-06 -1.11542714896545 9.14769438027749e-05 miRNAWalker2_validate -0.116822025399253 4.8352441908814e-05 NA NA NA hsa-miR-25-3p DST 1.36472605225697 4.83790725935681e-11 -1.11542714896545 9.14769438027749e-05 mirMAP -0.463190924899351 5.76207783738202e-13 NA NA NA hsa-miR-26b-3p DST 2.18464160365372 2.11543189388328e-18 -1.11542714896545 9.14769438027749e-05 mirMAP -0.164055048579398 0.00217191499140937 NA NA NA hsa-miR-3065-3p DST 2.16221780121195 9.65525739884541e-09 -1.11542714896545 9.14769438027749e-05 mirMAP -0.182940005973304 3.25312998112091e-07 NA NA NA hsa-miR-30d-3p DST 0.977747550180601 4.3048212205381e-05 -1.11542714896545 9.14769438027749e-05 mirMAP -0.160914133681715 0.00557624501987936 NA NA NA hsa-miR-3127-5p DST 1.51846438737133 3.59571251672767e-07 -1.11542714896545 9.14769438027749e-05 mirMAP -0.243650152985323 8.37121712602559e-08 NA NA NA hsa-miR-32-5p DST 2.34056473219422 6.24134585974322e-20 -1.11542714896545 9.14769438027749e-05 miRNAWalker2_validate;mirMAP -0.238544808112042 3.7384304559942e-06 NA NA NA hsa-miR-326 DST 0.715313016136042 0.0610265683213359 -1.11542714896545 9.14769438027749e-05 miRanda;mirMAP -0.13208311224818 0.000286310505298768 NA NA NA hsa-miR-335-5p DST 1.77247705492746 2.22457658872091e-06 -1.11542714896545 9.14769438027749e-05 miRNAWalker2_validate -0.100569110968399 0.00607972429463692 NA NA NA hsa-miR-33a-5p DST 3.79671563098419 1.15966309820345e-18 -1.11542714896545 9.14769438027749e-05 mirMAP -0.125906883491358 0.000171549801918499 NA NA NA hsa-miR-345-5p DST 3.63532310411307 2.2698112107996e-21 -1.11542714896545 9.14769438027749e-05 mirMAP -0.186013635628688 4.585345396444e-08 NA NA NA hsa-miR-34a-3p DST 1.75590866103657 8.02801510630657e-09 -1.11542714896545 9.14769438027749e-05 mirMAP -0.151845585320507 0.00234549283857459 NA NA NA hsa-miR-361-5p DST 0.971859117235239 5.30236555707088e-09 -1.11542714896545 9.14769438027749e-05 mirMAP -0.24754874429799 0.00294370869435802 NA NA NA hsa-miR-362-5p DST 1.59303749908759 9.582675908797e-08 -1.11542714896545 9.14769438027749e-05 TargetScan;mirMAP -0.287228482028304 1.80705108384957e-10 NA NA NA hsa-miR-363-3p DST 1.50575300026701 0.00020976164678918 -1.11542714896545 9.14769438027749e-05 mirMAP -0.213400587914375 1.53517775710511e-10 NA NA NA hsa-miR-429 DST 4.48815175680773 2.44117492218206e-17 -1.11542714896545 9.14769438027749e-05 miRanda;mirMAP;miRNATAP -0.1423154311456 9.09032112657027e-09 NA NA NA hsa-miR-450b-5p DST 1.69244418548325 1.68064054148881e-10 -1.11542714896545 9.14769438027749e-05 mirMAP -0.172660810816876 0.000776519227803537 NA NA NA hsa-miR-484 DST 1.81844463411787 1.82951571230938e-15 -1.11542714896545 9.14769438027749e-05 miRNAWalker2_validate -0.373614621808623 1.07418311401411e-10 NA NA NA hsa-miR-491-5p DST 0.615770352820862 0.0418295628761654 -1.11542714896545 9.14769438027749e-05 miRanda -0.168181335019031 0.000628981712039069 NA NA NA hsa-miR-500a-3p DST 1.47161373123699 5.30571342631915e-09 -1.11542714896545 9.14769438027749e-05 mirMAP -0.351908856860302 3.79612127318846e-11 NA NA NA hsa-miR-505-3p DST 1.45322244209148 8.86597629645867e-10 -1.11542714896545 9.14769438027749e-05 mirMAP -0.201287630809282 0.000474134607572414 NA NA NA hsa-miR-532-3p DST 1.96631878320218 4.53421954361695e-13 -1.11542714896545 9.14769438027749e-05 mirMAP -0.270039007156901 4.0490566680601e-08 NA NA NA hsa-miR-532-5p DST 1.55697650978597 1.57884735535196e-11 -1.11542714896545 9.14769438027749e-05 mirMAP -0.391324512674282 1.21360862684875e-11 NA NA NA hsa-miR-590-3p DST 2.59289455139753 1.03200520972022e-21 -1.11542714896545 9.14769438027749e-05 PITA;miRanda;mirMAP -0.233583257181658 2.75000894778127e-06 NA NA NA hsa-miR-590-5p DST 3.18300989862077 2.06813568597893e-26 -1.11542714896545 9.14769438027749e-05 mirMAP -0.248329493560057 1.95777022574207e-08 NA NA NA hsa-miR-629-3p DST 2.36570947321815 1.33458201201618e-11 -1.11542714896545 9.14769438027749e-05 mirMAP -0.171170767339052 8.85815709577049e-05 NA NA NA hsa-miR-629-5p DST 2.10182419359635 1.51788571125757e-15 -1.11542714896545 9.14769438027749e-05 mirMAP -0.150763213786465 0.00314324377197186 NA NA NA hsa-miR-664a-3p DST 0.634721925861133 0.00520070178640421 -1.11542714896545 9.14769438027749e-05 mirMAP -0.172760297992216 0.00489963169396905 NA NA NA hsa-miR-744-3p DST 2.7517405670917 4.22040908411227e-14 -1.11542714896545 9.14769438027749e-05 mirMAP -0.146354849610072 6.89416965228565e-05 NA NA NA hsa-miR-769-3p DST 2.19896922202687 5.69250370895053e-12 -1.11542714896545 9.14769438027749e-05 mirMAP -0.221258329577558 3.22640511191076e-07 NA NA NA hsa-miR-92a-3p DST 2.06460102658973 1.44784291084757e-19 -1.11542714896545 9.14769438027749e-05 mirMAP -0.312939841748471 6.13408768113513e-08 NA NA NA hsa-miR-93-5p DST 3.03961860136032 1.11672209617395e-24 -1.11542714896545 9.14769438027749e-05 mirMAP -0.330738418598868 1.37464929429933e-14 NA NA NA hsa-miR-324-5p ECM1 2.95683728155095 1.32960514360912e-20 -1.15886819285361 0.00138361491554546 miRanda -0.2601605381159 6.68329506501801e-07 NA NA NA hsa-miR-330-5p ECM1 1.15100069700871 4.85551805046014e-07 -1.15886819285361 0.00138361491554546 miRanda -0.298786538556538 8.71895791951164e-05 NA NA NA hsa-miR-429 ECM1 4.48815175680773 2.44117492218206e-17 -1.15886819285361 0.00138361491554546 miRNATAP -0.280795991860487 3.02746588968453e-20 NA NA NA hsa-miR-125a-3p ECM2 1.24490295132072 5.26925231010328e-06 -1.8670507868567 5.00700510630595e-07 miRanda -0.242587867954785 0.000237642310392264 NA NA NA hsa-miR-1296-5p ECM2 1.20556568733873 8.93601534401924e-06 -1.8670507868567 5.00700510630595e-07 MirTarget -0.352494959695615 8.67306174149664e-08 NA NA NA hsa-miR-16-2-3p ECM2 2.31623086727196 4.29838149388188e-20 -1.8670507868567 5.00700510630595e-07 mirMAP -0.600281619626137 1.27228365330877e-19 NA NA NA hsa-miR-3065-5p ECM2 2.74629919868982 1.86846589298284e-08 -1.8670507868567 5.00700510630595e-07 mirMAP -0.216243652484476 1.18372039749406e-06 NA NA NA hsa-miR-30d-3p ECM2 0.977747550180601 4.3048212205381e-05 -1.8670507868567 5.00700510630595e-07 MirTarget -0.693485268063709 1.11098992690287e-21 NA NA NA hsa-miR-30e-3p ECM2 -0.215663037684509 0.235375122783546 -1.8670507868567 5.00700510630595e-07 MirTarget -0.575428993424834 9.26050990964415e-09 NA NA NA hsa-miR-320a ECM2 0.438165828017084 0.0390159073347133 -1.8670507868567 5.00700510630595e-07 miRanda -0.570415710876777 1.54195502904406e-11 NA NA NA hsa-miR-320b ECM2 1.55692969039548 1.41071034251915e-08 -1.8670507868567 5.00700510630595e-07 miRanda -0.485762026502687 2.05821327253821e-14 NA NA NA hsa-miR-331-5p ECM2 2.17414714166315 1.54547681391888e-18 -1.8670507868567 5.00700510630595e-07 MirTarget -0.643033559311705 2.46063747853589e-20 NA NA NA hsa-miR-335-3p ECM2 3.08791651139852 5.31309869723517e-12 -1.8670507868567 5.00700510630595e-07 MirTarget -0.203008074635452 2.12523259190154e-07 NA NA NA hsa-miR-421 ECM2 1.17791565395543 6.78526676976629e-06 -1.8670507868567 5.00700510630595e-07 miRanda -0.418494704762336 8.06377028245267e-10 NA NA NA hsa-miR-452-3p ECM2 2.42521958420768 4.08754552781156e-07 -1.8670507868567 5.00700510630595e-07 MirTarget -0.163098102687223 1.28960354281452e-05 NA NA NA hsa-miR-590-3p ECM2 2.59289455139753 1.03200520972022e-21 -1.8670507868567 5.00700510630595e-07 MirTarget;miRanda;miRNATAP -0.527598761586317 1.02892197017699e-16 NA NA NA hsa-miR-590-5p ECM2 3.18300989862077 2.06813568597893e-26 -1.8670507868567 5.00700510630595e-07 miRanda -0.499728149620798 8.19943778760258e-19 NA NA NA hsa-miR-7-1-3p ECM2 1.84950311431067 1.25300363397654e-13 -1.8670507868567 5.00700510630595e-07 MirTarget -0.519625544593705 5.65945920319292e-14 NA NA NA hsa-miR-944 ECM2 2.91186649218281 1.31574753528144e-06 -1.8670507868567 5.00700510630595e-07 mirMAP -0.262097735911834 7.67608407639407e-19 NA NA NA hsa-miR-98-5p ECM2 1.11154309866014 1.24143909012085e-08 -1.8670507868567 5.00700510630595e-07 miRNAWalker2_validate -0.661393202094764 2.30592843047136e-13 NA NA NA hsa-let-7a-3p EDIL3 1.42015538786275 7.03375209382654e-13 -1.39552344263701 0.00540706010756216 MirTarget -0.339658361968357 0.00495377765130581 NA NA NA hsa-miR-107 EDIL3 1.30977326593435 1.30372468603965e-11 -1.39552344263701 0.00540706010756216 miRanda -0.415667459393642 0.000787714345212023 NA NA NA hsa-miR-16-2-3p EDIL3 2.31623086727196 4.29838149388188e-20 -1.39552344263701 0.00540706010756216 mirMAP -0.615971403006198 9.54979192612657e-12 NA NA NA hsa-miR-182-5p EDIL3 3.53923166221814 5.07781258121574e-21 -1.39552344263701 0.00540706010756216 MirTarget -0.292534452921023 1.64376711255295e-06 NA NA NA hsa-miR-186-5p EDIL3 1.47445398888668 3.0781726595413e-15 -1.39552344263701 0.00540706010756216 mirMAP -0.787417388799717 2.9739834460297e-10 NA NA NA hsa-miR-29b-1-5p EDIL3 1.55384379072167 4.76870585070176e-05 -1.39552344263701 0.00540706010756216 MirTarget -0.250830525369519 0.000174540318592789 NA NA NA hsa-miR-32-3p EDIL3 2.02436999565685 5.94091197945307e-09 -1.39552344263701 0.00540706010756216 mirMAP -0.393873772292322 3.96184680533413e-07 NA NA NA hsa-miR-361-5p EDIL3 0.971859117235239 5.30236555707088e-09 -1.39552344263701 0.00540706010756216 MirTarget;miRanda -0.669056622473574 3.86679544289268e-06 NA NA NA hsa-miR-374a-3p EDIL3 0.533309330504947 0.00192918429705142 -1.39552344263701 0.00540706010756216 MirTarget -0.461902619871505 0.00124172914721174 NA NA NA hsa-miR-425-5p EDIL3 3.07071373939774 4.02947460586085e-25 -1.39552344263701 0.00540706010756216 MirTarget -0.457040277495106 1.99795176784073e-09 NA NA NA hsa-miR-501-5p EDIL3 1.93654809410041 1.3779381780759e-10 -1.39552344263701 0.00540706010756216 mirMAP -0.376781883033253 3.10440777893629e-06 NA NA NA hsa-miR-590-3p EDIL3 2.59289455139753 1.03200520972022e-21 -1.39552344263701 0.00540706010756216 miRanda;mirMAP -0.498945250019651 8.90108924313381e-09 NA NA NA hsa-miR-590-5p EDIL3 3.18300989862077 2.06813568597893e-26 -1.39552344263701 0.00540706010756216 MirTarget;miRNATAP -0.475402188168855 7.48118984219464e-10 NA NA NA hsa-miR-7-1-3p EDIL3 1.84950311431067 1.25300363397654e-13 -1.39552344263701 0.00540706010756216 MirTarget -0.416440433269686 1.0413970406096e-05 NA NA NA hsa-miR-940 EDIL3 3.21011374578759 2.7923171128495e-14 -1.39552344263701 0.00540706010756216 MirTarget;PITA -0.161488445089268 0.0081416297374749 NA NA NA hsa-miR-944 EDIL3 2.91186649218281 1.31574753528144e-06 -1.39552344263701 0.00540706010756216 MirTarget -0.171404896592648 2.85903862465525e-05 NA NA NA hsa-miR-128-3p EFEMP2 1.63756041666078 6.79626586407187e-14 -1.15835552823615 0.000134918810215867 miRNAWalker2_validate -0.407883097437693 3.13266566669932e-10 NA NA NA hsa-miR-324-3p EFEMP2 2.08739139768981 3.11885987067952e-13 -1.15835552823615 0.000134918810215867 MirTarget -0.29929793814205 1.37765800237776e-09 NA NA NA hsa-miR-330-5p EFEMP2 1.15100069700871 4.85551805046014e-07 -1.15835552823615 0.000134918810215867 miRanda -0.319058497916893 5.13890968333839e-07 NA NA NA hsa-miR-629-3p EFEMP2 2.36570947321815 1.33458201201618e-11 -1.15835552823615 0.000134918810215867 MirTarget -0.199385721905903 1.71236023228563e-05 NA NA NA hsa-miR-144-3p ELN 0.658119849508907 0.146943823997989 -3.06155893028078 1.51406596135503e-08 miRNATAP -0.290499466446607 1.27909801016211e-06 NA NA NA hsa-miR-29b-3p ELN 1.65828197923813 1.02676780888141e-09 -3.06155893028078 1.51406596135503e-08 MirTarget;miRNATAP -0.477737903528116 5.59491948747506e-07 NA NA NA hsa-miR-331-3p ELN 2.28379581858927 1.99663919173155e-18 -3.06155893028078 1.51406596135503e-08 MirTarget;PITA -0.924696547371869 3.34361400887801e-23 NA NA NA hsa-miR-361-3p ELN 1.07367425434318 1.73142774168958e-09 -3.06155893028078 1.51406596135503e-08 PITA;mirMAP -0.766488418428683 1.78617681051361e-07 NA NA NA hsa-miR-3614-5p ELN 2.17736331059655 2.19144831318484e-08 -3.06155893028078 1.51406596135503e-08 mirMAP -0.513689088449959 3.31223753616677e-14 NA NA NA hsa-miR-421 ELN 1.17791565395543 6.78526676976629e-06 -3.06155893028078 1.51406596135503e-08 miRanda -0.603710683107731 1.38951677448435e-09 NA NA NA hsa-miR-423-5p ELN 0.963563145758616 9.86109015204915e-07 -3.06155893028078 1.51406596135503e-08 MirTarget -0.901467823301383 8.58660938369604e-12 NA NA NA hsa-miR-429 ELN 4.48815175680773 2.44117492218206e-17 -3.06155893028078 1.51406596135503e-08 miRNATAP -0.297250192926291 3.295676571383e-10 NA NA NA hsa-miR-491-5p ELN 0.615770352820862 0.0418295628761654 -3.06155893028078 1.51406596135503e-08 MirTarget;miRanda;miRNATAP -0.383763577397027 4.48970347516682e-05 NA NA NA hsa-miR-26b-5p EMP3 0.885393662798425 3.2116297961629e-06 -1.69766273916557 1.80799806590165e-05 miRNAWalker2_validate -0.349970761454836 0.000567558211060338 NA NA NA hsa-miR-338-3p ENO2 0.453166438193782 0.144583389707558 0.0977474375543386 0.757840831570205 miRanda -0.182947120489243 0.000201710994222882 NA NA NA hsa-miR-30c-5p FAP 0.778774633108 0.000285599212429136 0.811741651660897 0.168731033359055 miRNATAP -1.06954321253161 8.73017925182496e-17 NA NA NA hsa-miR-30d-5p FAP 0.675423997639582 0.00270618816039773 0.811741651660897 0.168731033359055 miRNATAP -1.44880547562811 3.05809678299166e-35 NA NA NA hsa-miR-330-3p FAP 0.876747334239085 0.00073709016089703 0.811741651660897 0.168731033359055 PITA;miRNATAP -0.828930527398661 6.76136514757041e-15 NA NA NA hsa-miR-375 FAP 1.13910305294079 0.0512283522214186 0.811741651660897 0.168731033359055 miRanda -0.16345695202425 0.000764416555866564 NA NA NA hsa-miR-429 FAP 4.48815175680773 2.44117492218206e-17 0.811741651660897 0.168731033359055 miRNATAP -0.467467085880431 2.11001136640005e-21 NA NA NA hsa-let-7a-5p FAS 0.618599506841644 2.76973453058748e-05 -0.893121037137088 0.00675655818216232 TargetScan -0.294996828851615 0.0073114418152214 NA NA NA hsa-miR-106a-5p FAS 2.48882002962836 1.99757727374521e-12 -0.893121037137088 0.00675655818216232 miRNAWalker2_validate;miRTarBase -0.286433262215431 2.93487884151059e-11 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-23b-3p FAS -0.251132426825047 0.150200321210792 -0.893121037137088 0.00675655818216232 miRNATAP -0.391116610184141 2.37246599324584e-05 24356489 Moreover over-expression of Fas rescued the pro-proliferation effect of miR-23 indicating Fas is a direct mediator of miR-23 functions; Furthermore contrast to miR-23a/b which was up regulated the Fas expression level was down-regulated and inversely correlated with miR-23 in split radiation induced lymphoma tissue samples; Finally our data also indicates that miR-23a could repress Fas much more potent than miR-23b and the additional region besides conserved seed pairing enables miR-23a's higher regulation lymphoma hsa-miR-361-5p FAS 0.971859117235239 5.30236555707088e-09 -0.893121037137088 0.00675655818216232 miRanda -0.765596610913641 1.34005865686507e-16 NA NA NA hsa-miR-491-5p FAS 0.615770352820862 0.0418295628761654 -0.893121037137088 0.00675655818216232 miRanda -0.202143347610942 0.000355416125267629 NA NA NA hsa-miR-590-5p FAS 3.18300989862077 2.06813568597893e-26 -0.893121037137088 0.00675655818216232 miRanda -0.26445516527792 2.22188286955534e-07 NA NA NA hsa-miR-98-5p FAS 1.11154309866014 1.24143909012085e-08 -0.893121037137088 0.00675655818216232 miRNAWalker2_validate -0.770550954607501 1.78193866759893e-23 NA NA NA hsa-miR-24-3p FBLN1 0.99989036772428 1.35595013650376e-07 -1.74207967924837 0.000101455469687111 MirTarget -0.832125451989742 9.28973324309975e-14 NA NA NA hsa-miR-128-3p FBLN2 1.63756041666078 6.79626586407187e-14 -3.08227199202065 3.68154511729326e-10 MirTarget -0.815136814452386 1.05224176979929e-14 NA NA NA hsa-miR-335-5p FBLN2 1.77247705492746 2.22457658872091e-06 -3.08227199202065 3.68154511729326e-10 miRNAWalker2_validate -0.209128498674202 0.00109513692854984 NA NA NA hsa-miR-744-5p FBLN2 1.48254348878737 3.23019501613577e-09 -3.08227199202065 3.68154511729326e-10 MirTarget -0.708057702142402 2.6193704739853e-14 NA NA NA hsa-miR-125a-3p FBLN5 1.24490295132072 5.26925231010328e-06 -2.7572810002915 1.11240697718667e-13 miRanda -0.333480536257992 5.67927894526624e-07 NA NA NA hsa-miR-129-5p FBLN5 -0.524170159980738 0.222582956006346 -2.7572810002915 1.11240697718667e-13 miRanda -0.158132988045075 0.00030691787822222 NA NA NA hsa-miR-200c-3p FBLN5 3.50132673580082 2.42716349086937e-15 -2.7572810002915 1.11240697718667e-13 miRNAWalker2_validate;miRTarBase -0.400109932439159 7.56529266726843e-26 NA NA NA hsa-miR-26b-5p FBLN5 0.885393662798425 3.2116297961629e-06 -2.7572810002915 1.11240697718667e-13 miRNAWalker2_validate -0.535526893921341 2.56766257349486e-08 NA NA NA hsa-miR-330-3p FBLN5 0.876747334239085 0.00073709016089703 -2.7572810002915 1.11240697718667e-13 miRNATAP -0.458504480756808 5.03240243201365e-11 NA NA NA hsa-miR-335-5p FBLN5 1.77247705492746 2.22457658872091e-06 -2.7572810002915 1.11240697718667e-13 miRNAWalker2_validate -0.177861492038139 0.000260715406334917 NA NA NA hsa-miR-429 FBLN5 4.48815175680773 2.44117492218206e-17 -2.7572810002915 1.11240697718667e-13 miRanda;miRNATAP -0.303366238387041 2.16163874956495e-21 NA NA NA hsa-miR-769-5p FBLN5 1.82023760596845 9.6815886564134e-14 -2.7572810002915 1.11240697718667e-13 PITA -0.666130323312818 3.11777492145067e-21 NA NA NA hsa-let-7a-3p FBN1 1.42015538786275 7.03375209382654e-13 -1.81792584376713 5.27450945120085e-05 mirMAP -0.530676491671978 8.59788523891157e-07 NA NA NA hsa-miR-126-5p FBN1 0.895338176458417 2.33372756450713e-05 -1.81792584376713 5.27450945120085e-05 mirMAP -0.38395046434659 0.000200366705971279 NA NA NA hsa-miR-129-5p FBN1 -0.524170159980738 0.222582956006346 -1.81792584376713 5.27450945120085e-05 mirMAP -0.207959247253356 5.93312532261347e-05 NA NA NA hsa-miR-16-2-3p FBN1 2.31623086727196 4.29838149388188e-20 -1.81792584376713 5.27450945120085e-05 mirMAP -0.639484902001315 2.22793786308809e-15 NA NA NA hsa-miR-182-5p FBN1 3.53923166221814 5.07781258121574e-21 -1.81792584376713 5.27450945120085e-05 miRNATAP -0.54842784532456 9.57298560258998e-26 NA NA NA hsa-miR-188-5p FBN1 2.52825126596644 6.78099435999778e-14 -1.81792584376713 5.27450945120085e-05 PITA -0.255316335816464 0.000137595125323996 NA NA NA hsa-miR-192-5p FBN1 2.69002528723195 1.22990188194432e-16 -1.81792584376713 5.27450945120085e-05 miRNAWalker2_validate -0.553246082532255 7.84352916222601e-19 NA NA NA hsa-miR-19b-1-5p FBN1 2.57951428759379 4.31576118703427e-20 -1.81792584376713 5.27450945120085e-05 mirMAP -0.645260099982138 2.07723742434215e-18 NA NA NA hsa-miR-215-5p FBN1 2.30755467422978 2.38476032118039e-06 -1.81792584376713 5.27450945120085e-05 miRNAWalker2_validate -0.270807233337841 1.58280507003575e-09 NA NA NA hsa-miR-23a-3p FBN1 1.00493340843378 2.55313889288924e-08 -1.81792584376713 5.27450945120085e-05 miRNATAP -0.327756426749805 0.00686388778666499 NA NA NA hsa-miR-25-3p FBN1 1.36472605225697 4.83790725935681e-11 -1.81792584376713 5.27450945120085e-05 mirMAP -0.762769281928441 4.82435490680823e-14 NA NA NA hsa-miR-29b-3p FBN1 1.65828197923813 1.02676780888141e-09 -1.81792584376713 5.27450945120085e-05 miRNATAP -0.470164343171605 1.74354435631196e-09 NA NA NA hsa-miR-29c-3p FBN1 -0.00968972577705429 0.97099586346872 -1.81792584376713 5.27450945120085e-05 miRNAWalker2_validate;miRTarBase -0.588093421481386 2.93015014480416e-13 NA NA NA hsa-miR-3065-5p FBN1 2.74629919868982 1.86846589298284e-08 -1.81792584376713 5.27450945120085e-05 mirMAP -0.224408332711281 3.03144296508188e-05 NA NA NA hsa-miR-32-3p FBN1 2.02436999565685 5.94091197945307e-09 -1.81792584376713 5.27450945120085e-05 miRNATAP -0.549930921358018 8.95120504435448e-16 NA NA NA hsa-miR-361-5p FBN1 0.971859117235239 5.30236555707088e-09 -1.81792584376713 5.27450945120085e-05 mirMAP -1.19587261214591 1.38748896982819e-21 NA NA NA hsa-miR-362-3p FBN1 2.0756816987665 3.89026064579331e-12 -1.81792584376713 5.27450945120085e-05 miRanda;miRNATAP -0.198218431020178 0.00741242194990771 NA NA NA hsa-miR-363-3p FBN1 1.50575300026701 0.00020976164678918 -1.81792584376713 5.27450945120085e-05 mirMAP -0.342075888583744 7.81802983570473e-11 NA NA NA hsa-miR-374a-5p FBN1 0.484615721953736 0.0042981729815149 -1.81792584376713 5.27450945120085e-05 mirMAP -0.454218021851124 0.000506489619911916 NA NA NA hsa-miR-375 FBN1 1.13910305294079 0.0512283522214186 -1.81792584376713 5.27450945120085e-05 mirMAP -0.149360046164764 6.03082164291762e-05 NA NA NA hsa-miR-421 FBN1 1.17791565395543 6.78526676976629e-06 -1.81792584376713 5.27450945120085e-05 mirMAP -0.432587850871208 1.5931959577349e-07 NA NA NA hsa-miR-429 FBN1 4.48815175680773 2.44117492218206e-17 -1.81792584376713 5.27450945120085e-05 miRNATAP -0.459859359574728 1.22181420436588e-36 NA NA NA hsa-miR-486-5p FBN1 -0.194913133034028 0.607377798807705 -1.81792584376713 5.27450945120085e-05 PITA;miRanda;miRNATAP -0.222480233370535 0.000113609171865976 27133060 miR 486 5p inhibits cell growth of papillary thyroid carcinoma by targeting fibrillin 1; Fibrillin-1 FBN1 was shown to be a direct target of miR-486-5p and inversely regulated by miR-486-5p; FBN1 silencing led to decreased PTC cell proliferation and enhanced apoptosis in vitro similar to that mediated by miR-486-5p; Furthermore miR-486-5p over-expression or FBN1 knock-down inhibited while up-regulation of FBN1 boosted xenograft tumor formation in vivo; Our data suggest that miR-486-5p induces PTC cell growth inhibition and apoptosis by targeting and suppressing FBN1 thyroid cancer hsa-miR-576-5p FBN1 2.20467023993664 3.4053475193793e-19 -1.81792584376713 5.27450945120085e-05 mirMAP -0.584912134558186 2.56255189198688e-12 NA NA NA hsa-miR-582-5p FBN1 0.609226359812689 0.032988717891497 -1.81792584376713 5.27450945120085e-05 miRNATAP -0.609950706565863 2.16013190459084e-16 NA NA NA hsa-miR-590-3p FBN1 2.59289455139753 1.03200520972022e-21 -1.81792584376713 5.27450945120085e-05 miRanda;mirMAP -0.537903370510603 3.81803914698451e-12 NA NA NA hsa-miR-92a-3p FBN1 2.06460102658973 1.44784291084757e-19 -1.81792584376713 5.27450945120085e-05 mirMAP -0.91134692611276 1.33214964678827e-25 NA NA NA hsa-miR-944 FBN1 2.91186649218281 1.31574753528144e-06 -1.81792584376713 5.27450945120085e-05 PITA;mirMAP -0.365604931460848 1.490557687895e-25 NA NA NA hsa-miR-582-3p FBN2 0.00876844181512659 0.977126166214707 2.25292342840433 0.000567672424489425 PITA;miRNATAP -0.314835949064004 0.00254085987991877 NA NA NA hsa-miR-944 FBN2 2.91186649218281 1.31574753528144e-06 2.25292342840433 0.000567672424489425 mirMAP -0.177528593169998 0.000950598098550477 NA NA NA hsa-miR-103a-3p FERMT2 1.44083190496858 1.53799939616416e-13 -2.62997740238291 6.83872718492897e-15 MirTarget -0.91283181547249 6.88953219392515e-31 NA NA NA hsa-miR-107 FERMT2 1.30977326593435 1.30372468603965e-11 -2.62997740238291 6.83872718492897e-15 MirTarget;miRanda;miRNATAP -0.762415621296836 1.92772989943861e-20 NA NA NA hsa-miR-129-5p FERMT2 -0.524170159980738 0.222582956006346 -2.62997740238291 6.83872718492897e-15 miRanda -0.110481695123844 0.00587107810760169 NA NA NA hsa-miR-144-5p FERMT2 0.195856574290527 0.61856475838049 -2.62997740238291 6.83872718492897e-15 MirTarget -0.182286179516478 1.99295101924263e-05 NA NA NA hsa-miR-15a-5p FERMT2 2.34669284378787 1.69544424500258e-23 -2.62997740238291 6.83872718492897e-15 MirTarget;miRNATAP -0.702749249654398 5.81867426687326e-28 NA NA NA hsa-miR-15b-5p FERMT2 1.57112623124278 9.14247846750597e-13 -2.62997740238291 6.83872718492897e-15 MirTarget;miRNATAP -0.770691717066376 9.0119793507755e-28 NA NA NA hsa-miR-16-5p FERMT2 1.75824877145857 1.68592440033108e-16 -2.62997740238291 6.83872718492897e-15 MirTarget;miRNATAP -0.80253420566467 6.0481419966265e-29 NA NA NA hsa-miR-200b-3p FERMT2 3.78235093249346 3.18343003239465e-14 -2.62997740238291 6.83872718492897e-15 TargetScan -0.444322854953888 9.57401666889774e-54 23483548;24064224;26334393 Here we report that Kindlin 2 markedly downregulates the expression of miR-200 family by inducing CpG island hypermethylation; Our data indicate that Kindlin 2 plays a novel role in epigenetic repression of miR-200 family a mechanism that promotes breast cancer invasion;miR 200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin 2; Quantitative mass spectrometry identified 57 putative miR-200b targets including Kindlin-2 previously implicated in the regulation of tumor invasiveness and actin cytoskeleton in other cell types; Enforced expression of miR-200b mimic in ESCC cells led to a decrease of Kindlin-2 expression whereas transfection of miR-200b inhibitor induced Kindlin-2 expression; Furthermore transfection of miR-200b mimic or knockdown of Kindlin-2 in ESCC cells decreased cell protrusion and focal adhesion FA formation reduced cell spreading and invasiveness/migration; Enforced expression of Kindlin-2 largely abrogated the inhibitory effects of miR-200b on ESCC cell invasiveness; The tumor suppressor effects of miR-200b may be due to its suppression of Kindlin-2 a novel target of miR-200b that modulates actin cytoskeleton FA formation and the migratory/invasiveness properties of ESCC;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ;; breast cancer;esophageal cancer;esophageal cancer hsa-miR-205-5p FERMT2 4.1389800495524 2.05488295686453e-12 -2.62997740238291 6.83872718492897e-15 miRNATAP -0.332940304835859 2.26036468438318e-39 NA NA NA hsa-miR-21-5p FERMT2 2.73773305747971 1.38864982139576e-43 -2.62997740238291 6.83872718492897e-15 miRNAWalker2_validate -0.382799442660283 5.99044819328367e-07 NA NA NA hsa-miR-29b-3p FERMT2 1.65828197923813 1.02676780888141e-09 -2.62997740238291 6.83872718492897e-15 MirTarget;miRNATAP -0.471425202577017 1.7349701890438e-15 NA NA NA hsa-miR-29c-3p FERMT2 -0.00968972577705429 0.97099586346872 -2.62997740238291 6.83872718492897e-15 MirTarget;miRNATAP -0.42489246432308 9.34848174118004e-12 NA NA NA hsa-miR-30b-5p FERMT2 0.800822374912712 0.000133601914525413 -2.62997740238291 6.83872718492897e-15 miRNAWalker2_validate -0.568409895475326 5.10940163320255e-13 NA NA NA hsa-miR-32-3p FERMT2 2.02436999565685 5.94091197945307e-09 -2.62997740238291 6.83872718492897e-15 MirTarget -0.409613162467408 8.99880023707323e-15 NA NA NA hsa-miR-320a FERMT2 0.438165828017084 0.0390159073347133 -2.62997740238291 6.83872718492897e-15 miRanda -0.578032833901493 1.31016217013045e-13 NA NA NA hsa-miR-320b FERMT2 1.55692969039548 1.41071034251915e-08 -2.62997740238291 6.83872718492897e-15 miRanda -0.542935118072241 7.40869753434107e-21 NA NA NA hsa-miR-328-3p FERMT2 0.596804159297544 0.013858523511843 -2.62997740238291 6.83872718492897e-15 MirTarget -0.276548802548775 7.11189012577823e-05 NA NA NA hsa-miR-34c-5p FERMT2 2.07190852984647 7.35776320806257e-08 -2.62997740238291 6.83872718492897e-15 miRanda -0.121349891370344 0.00857592338979069 NA NA NA hsa-miR-361-5p FERMT2 0.971859117235239 5.30236555707088e-09 -2.62997740238291 6.83872718492897e-15 miRanda -0.922426371453702 1.23434099143152e-21 NA NA NA hsa-miR-429 FERMT2 4.48815175680773 2.44117492218206e-17 -2.62997740238291 6.83872718492897e-15 miRanda;miRNATAP -0.411000454546135 1.29690245457375e-52 NA NA NA hsa-miR-454-3p FERMT2 2.47234127820054 1.12878018736016e-21 -2.62997740238291 6.83872718492897e-15 miRNATAP -0.627876396796155 3.01732638548566e-25 NA NA NA hsa-miR-486-5p FERMT2 -0.194913133034028 0.607377798807705 -2.62997740238291 6.83872718492897e-15 miRanda -0.146961560265355 0.000962826500950693 NA NA NA hsa-miR-582-3p FERMT2 0.00876844181512659 0.977126166214707 -2.62997740238291 6.83872718492897e-15 MirTarget;miRNATAP -0.266298411238252 1.2551687189923e-06 NA NA NA hsa-miR-582-5p FERMT2 0.609226359812689 0.032988717891497 -2.62997740238291 6.83872718492897e-15 MirTarget;miRNATAP -0.368008083538298 2.45290735004875e-10 NA NA NA hsa-miR-590-3p FERMT2 2.59289455139753 1.03200520972022e-21 -2.62997740238291 6.83872718492897e-15 MirTarget;miRanda;mirMAP;miRNATAP -0.568514689223025 1.2375311107958e-22 NA NA NA hsa-miR-590-5p FERMT2 3.18300989862077 2.06813568597893e-26 -2.62997740238291 6.83872718492897e-15 miRanda -0.565999204232794 1.41848464765471e-28 NA NA NA hsa-miR-7-1-3p FERMT2 1.84950311431067 1.25300363397654e-13 -2.62997740238291 6.83872718492897e-15 mirMAP -0.51341391445372 8.92304040926451e-16 NA NA NA hsa-let-7a-3p FGF2 1.42015538786275 7.03375209382654e-13 -3.45935256477983 3.20406041037898e-17 mirMAP -0.57039623316549 1.64408016446008e-08 NA NA NA hsa-let-7b-3p FGF2 0.868207752019623 1.30460056774366e-05 -3.45935256477983 3.20406041037898e-17 mirMAP -0.530485029047925 2.33230657638534e-07 NA NA NA hsa-let-7f-1-3p FGF2 1.55054488387679 7.31326775537952e-11 -3.45935256477983 3.20406041037898e-17 mirMAP -0.403619323347166 3.50383349222099e-06 NA NA NA hsa-miR-103a-3p FGF2 1.44083190496858 1.53799939616416e-13 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.951198901738798 5.80167380051094e-22 NA NA NA hsa-miR-107 FGF2 1.30977326593435 1.30372468603965e-11 -3.45935256477983 3.20406041037898e-17 MirTarget;PITA;miRanda;miRNATAP -0.746537045946991 3.12339725479843e-13 NA NA NA hsa-miR-10b-3p FGF2 0.77597971642517 0.00264877454133753 -3.45935256477983 3.20406041037898e-17 mirMAP -0.38765486044307 1.00531657460278e-06 NA NA NA hsa-miR-1226-3p FGF2 1.38118928579963 0.000205503474787488 -3.45935256477983 3.20406041037898e-17 MirTarget -0.406312709645584 4.86442323802081e-11 NA NA NA hsa-miR-144-3p FGF2 0.658119849508907 0.146943823997989 -3.45935256477983 3.20406041037898e-17 MirTarget -0.150660886736508 0.00130127640996876 NA NA NA hsa-miR-148a-5p FGF2 1.16173838132242 0.000148929299881612 -3.45935256477983 3.20406041037898e-17 mirMAP -0.175801486236704 0.00879070967495281 NA NA NA hsa-miR-15a-5p FGF2 2.34669284378787 1.69544424500258e-23 -3.45935256477983 3.20406041037898e-17 MirTarget;miRNATAP -0.8665754259228 1.51865052824555e-28 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 2.33847028227712 4.29662877950836e-19 -3.45935256477983 3.20406041037898e-17 mirMAP -0.698237395560323 2.98047943363042e-22 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 1.57112623124278 9.14247846750597e-13 -3.45935256477983 3.20406041037898e-17 MirTarget;miRNATAP -0.772339849603923 2.2379572945642e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 2.56983217111073 3.02262181237943e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.706717215195114 8.84760087286705e-25 NA NA NA hsa-miR-16-2-3p FGF2 2.31623086727196 4.29838149388188e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.642959805706348 1.63529117433717e-17 NA NA NA hsa-miR-16-5p FGF2 1.75824877145857 1.68592440033108e-16 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.791482784689716 1.7414135213028e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-181a-5p FGF2 2.29556023480783 1.8138457900616e-21 -3.45935256477983 3.20406041037898e-17 mirMAP -0.525450431942733 5.3421915793276e-11 NA NA NA hsa-miR-181b-5p FGF2 2.49307679431293 3.92829250217627e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.487813576366985 7.1537699850524e-12 NA NA NA hsa-miR-181c-5p FGF2 1.58587920618301 1.57506918816933e-10 -3.45935256477983 3.20406041037898e-17 mirMAP -0.402853563332211 6.66481994248428e-07 NA NA NA hsa-miR-186-5p FGF2 1.47445398888668 3.0781726595413e-15 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;mirMAP -0.865396245604199 9.71640315277788e-17 NA NA NA hsa-miR-192-5p FGF2 2.69002528723195 1.22990188194432e-16 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.55945113419736 8.27439417486679e-22 NA NA NA hsa-miR-19b-1-5p FGF2 2.57951428759379 4.31576118703427e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.684742945615863 1.47856020889472e-23 NA NA NA hsa-miR-200b-3p FGF2 3.78235093249346 3.18343003239465e-14 -3.45935256477983 3.20406041037898e-17 mirMAP -0.442848247331966 6.36624370256829e-33 NA NA NA hsa-miR-200c-3p FGF2 3.50132673580082 2.42716349086937e-15 -3.45935256477983 3.20406041037898e-17 mirMAP -0.581898672989235 1.2281612826909e-47 NA NA NA hsa-miR-20a-3p FGF2 2.92621109947706 2.49504904635375e-17 -3.45935256477983 3.20406041037898e-17 mirMAP -0.521338868643764 2.37178789361296e-20 NA NA NA hsa-miR-21-3p FGF2 2.19296355304364 4.63665722759779e-15 -3.45935256477983 3.20406041037898e-17 mirMAP -0.389762818312192 3.3064358783093e-08 NA NA NA hsa-miR-21-5p FGF2 2.73773305747971 1.38864982139576e-43 -3.45935256477983 3.20406041037898e-17 mirMAP -0.590129232102637 2.05709217680526e-10 NA NA NA hsa-miR-215-5p FGF2 2.30755467422978 2.38476032118039e-06 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.234704807386955 3.03139328926694e-08 NA NA NA hsa-miR-32-5p FGF2 2.34056473219422 6.24134585974322e-20 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.528631961245202 2.37324737115731e-12 NA NA NA hsa-miR-330-3p FGF2 0.876747334239085 0.00073709016089703 -3.45935256477983 3.20406041037898e-17 mirMAP -0.408493425882602 1.96553818290449e-07 NA NA NA hsa-miR-335-3p FGF2 3.08791651139852 5.31309869723517e-12 -3.45935256477983 3.20406041037898e-17 mirMAP -0.283343671500426 1.16812423839489e-10 NA NA NA hsa-miR-335-5p FGF2 1.77247705492746 2.22457658872091e-06 -3.45935256477983 3.20406041037898e-17 miRNATAP -0.204481115239778 0.000164239409089154 NA NA NA hsa-miR-361-5p FGF2 0.971859117235239 5.30236555707088e-09 -3.45935256477983 3.20406041037898e-17 mirMAP -1.05676685455326 5.59900406122503e-19 NA NA NA hsa-miR-429 FGF2 4.48815175680773 2.44117492218206e-17 -3.45935256477983 3.20406041037898e-17 mirMAP -0.410445998774638 1.8378122494787e-32 NA NA NA hsa-miR-450b-5p FGF2 1.69244418548325 1.68064054148881e-10 -3.45935256477983 3.20406041037898e-17 mirMAP -0.300742012229277 7.83074250991869e-05 NA NA NA hsa-miR-452-5p FGF2 1.37180058737183 0.00171494843537772 -3.45935256477983 3.20406041037898e-17 mirMAP -0.212195200331281 5.19684741170909e-06 NA NA NA hsa-miR-503-5p FGF2 3.66513190181895 6.60300917645278e-21 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.407288478531313 2.50922381458507e-15 NA NA NA hsa-miR-589-3p FGF2 2.51971841868825 2.39125940264107e-11 -3.45935256477983 3.20406041037898e-17 mirMAP -0.381356804586547 1.66276905891645e-10 NA NA NA hsa-miR-590-3p FGF2 2.59289455139753 1.03200520972022e-21 -3.45935256477983 3.20406041037898e-17 miRanda;mirMAP -0.518258185319804 1.08846109843951e-12 NA NA NA hsa-miR-590-5p FGF2 3.18300989862077 2.06813568597893e-26 -3.45935256477983 3.20406041037898e-17 miRanda;mirMAP -0.632565141691195 1.29154238410301e-23 NA NA NA hsa-miR-664a-3p FGF2 0.634721925861133 0.00520070178640421 -3.45935256477983 3.20406041037898e-17 mirMAP -0.355728775133404 9.0166815375644e-05 NA NA NA hsa-miR-92a-3p FGF2 2.06460102658973 1.44784291084757e-19 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.899992154982756 2.08015519442665e-28 NA NA NA hsa-miR-93-3p FGF2 2.85383869771942 5.64481766902125e-23 -3.45935256477983 3.20406041037898e-17 mirMAP -0.750363342236745 4.93373884627099e-33 NA NA NA hsa-miR-944 FGF2 2.91186649218281 1.31574753528144e-06 -3.45935256477983 3.20406041037898e-17 MirTarget -0.33196588658737 1.10637179732889e-23 NA NA NA hsa-let-7b-5p FLNA 0.604314269683977 0.00140009936153214 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.403177193243923 2.55918754075918e-05 NA NA NA hsa-miR-149-5p FLNA 2.94200492826326 4.93436498919036e-14 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.416191196137286 1.5962274408455e-22 NA NA NA hsa-miR-16-5p FLNA 1.75824877145857 1.68592440033108e-16 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.821633719130985 2.66124157726764e-26 NA NA NA hsa-miR-193b-3p FLNA 2.25711804611899 4.1940744806631e-14 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.15583811174074 0.00802902833961969 NA NA NA hsa-miR-200c-3p FLNA 3.50132673580082 2.42716349086937e-15 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.573278326556171 6.53243471319789e-65 NA NA NA hsa-miR-20a-5p FLNA 3.15577933619191 4.19753346442454e-25 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.564800020648001 6.19255464701142e-27 NA NA NA hsa-miR-324-5p FLNA 2.95683728155095 1.32960514360912e-20 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.59678532241766 1.71478663638803e-32 NA NA NA hsa-miR-331-3p FLNA 2.28379581858927 1.99663919173155e-18 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.745555941056727 9.58027751437445e-34 NA NA NA hsa-miR-378a-3p FLNA -0.10995720000828 0.716188270032681 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.491191935825633 1.88782049586854e-17 NA NA NA hsa-miR-484 FLNA 1.81844463411787 1.82951571230938e-15 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.831848183638064 2.17819747551506e-31 NA NA NA hsa-miR-92a-3p FLNA 2.06460102658973 1.44784291084757e-19 -2.62738684988354 4.5847076562045e-13 miRNAWalker2_validate -0.811332613287438 2.90624250691799e-30 NA NA NA hsa-miR-125a-3p FMOD 1.24490295132072 5.26925231010328e-06 -1.52192128466791 0.000151731290314199 MirTarget;miRanda -0.274551525384133 0.000107165531957214 NA NA NA hsa-miR-1266-5p FMOD 1.3763848124288 0.000876906064212958 -1.52192128466791 0.000151731290314199 MirTarget -0.346151062850925 5.22752672916726e-14 NA NA NA hsa-miR-185-3p FMOD 2.3922478518806 1.3373426768452e-14 -1.52192128466791 0.000151731290314199 MirTarget -0.490811411897822 8.06082630357698e-17 NA NA NA hsa-miR-28-5p FMOD 0.230152919654905 0.0742909586754846 -1.52192128466791 0.000151731290314199 miRanda -0.435064798748087 0.00551146073931312 NA NA NA hsa-miR-330-5p FMOD 1.15100069700871 4.85551805046014e-07 -1.52192128466791 0.000151731290314199 miRanda -0.549073925409279 4.25576592161974e-11 NA NA NA hsa-miR-429 FMOD 4.48815175680773 2.44117492218206e-17 -1.52192128466791 0.000151731290314199 miRNATAP -0.334052105988909 2.65340706573706e-23 NA NA NA hsa-miR-501-5p FMOD 1.93654809410041 1.3779381780759e-10 -1.52192128466791 0.000151731290314199 MirTarget -0.378726982469323 4.19944944874655e-09 NA NA NA hsa-miR-505-5p FMOD 1.89243395287645 9.82003586561819e-12 -1.52192128466791 0.000151731290314199 MirTarget -0.460936792962545 7.93907365143924e-12 NA NA NA hsa-miR-590-5p FMOD 3.18300989862077 2.06813568597893e-26 -1.52192128466791 0.000151731290314199 miRanda -0.515766381184504 2.37909229482919e-17 NA NA NA hsa-miR-7-1-3p FMOD 1.84950311431067 1.25300363397654e-13 -1.52192128466791 0.000151731290314199 mirMAP -0.501606019838189 2.00396725469355e-11 NA NA NA hsa-let-7g-5p FN1 1.20061455355116 1.50237505511483e-12 -0.407678263046535 0.457934813442308 miRTarBase -1.38356947455025 6.70079108156719e-21 NA NA NA hsa-miR-144-3p FN1 0.658119849508907 0.146943823997989 -0.407678263046535 0.457934813442308 MirTarget -0.258927409565794 1.57328800578319e-05 NA NA NA hsa-miR-16-1-3p FN1 2.56983217111073 3.02262181237943e-20 -0.407678263046535 0.457934813442308 mirMAP -0.597286521474049 7.38498382250215e-11 NA NA NA hsa-miR-200b-3p FN1 3.78235093249346 3.18343003239465e-14 -0.407678263046535 0.457934813442308 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.597950765256644 8.42251389081856e-37 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 3.50132673580082 2.42716349086937e-15 -0.407678263046535 0.457934813442308 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.661896693895972 1.64136219365611e-35 NA NA NA hsa-miR-26b-5p FN1 0.885393662798425 3.2116297961629e-06 -0.407678263046535 0.457934813442308 miRNAWalker2_validate -0.740291554820262 8.1789709477057e-08 NA NA NA hsa-miR-320a FN1 0.438165828017084 0.0390159073347133 -0.407678263046535 0.457934813442308 miRanda -1.04887566508125 5.02520748419077e-18 NA NA NA hsa-miR-320b FN1 1.55692969039548 1.41071034251915e-08 -0.407678263046535 0.457934813442308 miRanda -0.665480016494431 8.28719779629859e-13 NA NA NA hsa-miR-33a-3p FN1 1.72765312072219 1.51784443453521e-07 -0.407678263046535 0.457934813442308 mirMAP -0.720834465038679 1.19719425524499e-17 NA NA NA hsa-miR-429 FN1 4.48815175680773 2.44117492218206e-17 -0.407678263046535 0.457934813442308 MirTarget;PITA;miRanda;miRNATAP -0.526813403701254 2.58194150524164e-32 NA NA NA hsa-miR-590-3p FN1 2.59289455139753 1.03200520972022e-21 -0.407678263046535 0.457934813442308 miRanda;mirMAP -0.45878049547859 1.42151771675085e-06 NA NA NA hsa-miR-944 FN1 2.91186649218281 1.31574753528144e-06 -0.407678263046535 0.457934813442308 mirMAP -0.355794699553882 2.37688541107665e-16 NA NA NA hsa-miR-96-5p FN1 4.89433085814374 1.92000659886961e-31 -0.407678263046535 0.457934813442308 MirTarget;TargetScan -0.450514787117358 1.193321368228e-14 NA NA NA hsa-let-7a-3p FSTL1 1.42015538786275 7.03375209382654e-13 -1.20409366079041 3.08470468877507e-05 mirMAP -0.320297960297161 3.94552936551761e-06 NA NA NA hsa-let-7b-5p FSTL1 0.604314269683977 0.00140009936153214 -1.20409366079041 3.08470468877507e-05 miRNAWalker2_validate -0.354678317311399 1.89382191011213e-06 NA NA NA hsa-miR-103a-2-5p FSTL1 2.47599305985086 7.933028987326e-11 -1.20409366079041 3.08470468877507e-05 mirMAP -0.248892246387176 6.20003480962811e-10 NA NA NA hsa-miR-148a-5p FSTL1 1.16173838132242 0.000148929299881612 -1.20409366079041 3.08470468877507e-05 mirMAP -0.147440358623359 0.00126032949117954 NA NA NA hsa-miR-149-5p FSTL1 2.94200492826326 4.93436498919036e-14 -1.20409366079041 3.08470468877507e-05 miRNAWalker2_validate -0.158632127837716 4.81134821637939e-06 NA NA NA hsa-miR-181b-5p FSTL1 2.49307679431293 3.92829250217627e-20 -1.20409366079041 3.08470468877507e-05 mirMAP -0.166341294882472 0.000802054978572373 NA NA NA hsa-miR-181c-5p FSTL1 1.58587920618301 1.57506918816933e-10 -1.20409366079041 3.08470468877507e-05 mirMAP -0.216623201224403 9.91656306843916e-05 NA NA NA hsa-miR-18a-3p FSTL1 2.14813400940323 2.23460809936028e-06 -1.20409366079041 3.08470468877507e-05 MirTarget -0.148060895381834 0.000127010418846424 NA NA NA hsa-miR-200b-3p FSTL1 3.78235093249346 3.18343003239465e-14 -1.20409366079041 3.08470468877507e-05 MirTarget;TargetScan -0.316752721517746 1.30515335188224e-36 NA NA NA hsa-miR-200c-3p FSTL1 3.50132673580082 2.42716349086937e-15 -1.20409366079041 3.08470468877507e-05 MirTarget -0.363468259803467 2.09035802399296e-38 NA NA NA hsa-miR-203a-3p FSTL1 3.12352008343999 9.49391438647189e-07 -1.20409366079041 3.08470468877507e-05 MirTarget -0.143454386480385 1.66862533224055e-11 NA NA NA hsa-miR-20a-3p FSTL1 2.92621109947706 2.49504904635375e-17 -1.20409366079041 3.08470468877507e-05 mirMAP -0.282766617850179 5.93604432113225e-13 NA NA NA hsa-miR-26b-5p FSTL1 0.885393662798425 3.2116297961629e-06 -1.20409366079041 3.08470468877507e-05 miRNAWalker2_validate -0.392418318536272 8.5808717591393e-08 NA NA NA hsa-miR-27b-5p FSTL1 0.393316367667332 0.051702301924024 -1.20409366079041 3.08470468877507e-05 mirMAP -0.192261062597176 0.00632271628136597 NA NA NA hsa-miR-320a FSTL1 0.438165828017084 0.0390159073347133 -1.20409366079041 3.08470468877507e-05 miRanda -0.427506214092366 7.06163515560538e-11 NA NA NA hsa-miR-320b FSTL1 1.55692969039548 1.41071034251915e-08 -1.20409366079041 3.08470468877507e-05 miRanda -0.344245197563764 3.36675187445356e-12 NA NA NA hsa-miR-330-3p FSTL1 0.876747334239085 0.00073709016089703 -1.20409366079041 3.08470468877507e-05 mirMAP -0.363604888996401 6.79987938665774e-12 NA NA NA hsa-miR-335-3p FSTL1 3.08791651139852 5.31309869723517e-12 -1.20409366079041 3.08470468877507e-05 mirMAP -0.127020778238428 3.03404131937405e-05 NA NA NA hsa-miR-3607-3p FSTL1 2.68532138541128 5.66716351955047e-14 -1.20409366079041 3.08470468877507e-05 mirMAP -0.27614507524464 5.52353544331496e-13 NA NA NA hsa-miR-374a-5p FSTL1 0.484615721953736 0.0042981729815149 -1.20409366079041 3.08470468877507e-05 mirMAP -0.233956609593923 0.00543665334805216 NA NA NA hsa-miR-429 FSTL1 4.48815175680773 2.44117492218206e-17 -1.20409366079041 3.08470468877507e-05 MirTarget;PITA;miRanda -0.282431191303997 4.94825558308641e-33 NA NA NA hsa-miR-576-5p FSTL1 2.20467023993664 3.4053475193793e-19 -1.20409366079041 3.08470468877507e-05 mirMAP -0.368602931672034 7.06006132759806e-12 NA NA NA hsa-miR-584-5p FSTL1 2.7326672683732 9.92677936962233e-12 -1.20409366079041 3.08470468877507e-05 mirMAP -0.178028085100472 1.39594168008257e-07 NA NA NA hsa-miR-590-3p FSTL1 2.59289455139753 1.03200520972022e-21 -1.20409366079041 3.08470468877507e-05 miRanda;mirMAP -0.327360470513126 5.52845508592737e-11 NA NA NA hsa-miR-7-1-3p FSTL1 1.84950311431067 1.25300363397654e-13 -1.20409366079041 3.08470468877507e-05 MirTarget -0.378977506095772 1.72604963282941e-12 NA NA NA hsa-miR-9-5p FSTL1 1.02304182473283 0.042901377604859 -1.20409366079041 3.08470468877507e-05 MirTarget -0.116353093510078 2.57887195450719e-05 NA NA NA hsa-miR-944 FSTL1 2.91186649218281 1.31574753528144e-06 -1.20409366079041 3.08470468877507e-05 mirMAP -0.235041334665278 1.41627935050485e-25 NA NA NA hsa-miR-1226-3p FSTL3 1.38118928579963 0.000205503474787488 -0.2817727476014 0.492493095324307 mirMAP -0.381630730807628 1.37827042496299e-10 NA NA NA hsa-miR-185-3p FSTL3 2.3922478518806 1.3373426768452e-14 -0.2817727476014 0.492493095324307 MirTarget -0.323770348795238 1.2055255412716e-07 NA NA NA hsa-miR-20a-3p FSTL3 2.92621109947706 2.49504904635375e-17 -0.2817727476014 0.492493095324307 mirMAP -0.21798236024047 0.00011331665660483 NA NA NA hsa-miR-491-5p FSTL3 0.615770352820862 0.0418295628761654 -0.2817727476014 0.492493095324307 miRanda -0.237586871805079 0.000721602901079908 NA NA NA hsa-miR-9-5p FSTL3 1.02304182473283 0.042901377604859 -0.2817727476014 0.492493095324307 miRNAWalker2_validate -0.10948999324474 0.00515960091544401 NA NA NA hsa-miR-324-5p FZD8 2.95683728155095 1.32960514360912e-20 -0.823815646444258 0.00951023084929651 miRanda -0.279779712433669 7.35608925341817e-10 NA NA NA hsa-miR-429 FZD8 4.48815175680773 2.44117492218206e-17 -0.823815646444258 0.00951023084929651 miRanda -0.179347702117017 5.02703658451684e-11 NA NA NA hsa-miR-491-5p FZD8 0.615770352820862 0.0418295628761654 -0.823815646444258 0.00951023084929651 miRanda -0.185509761219535 0.000672381095466849 NA NA NA hsa-miR-590-3p FZD8 2.59289455139753 1.03200520972022e-21 -0.823815646444258 0.00951023084929651 miRanda -0.299591132423302 5.09896542046123e-08 NA NA NA hsa-miR-7-1-3p FZD8 1.84950311431067 1.25300363397654e-13 -0.823815646444258 0.00951023084929651 MirTarget -0.247871957087296 3.43262854275173e-05 NA NA NA hsa-miR-99b-5p FZD8 0.814286288944185 0.000299800699512742 -0.823815646444258 0.00951023084929651 MirTarget -0.211256090995937 0.00201196100333719 NA NA NA hsa-miR-130b-3p GADD45A 3.5350292994509 1.73934183852569e-27 -0.835839078652441 0.000140836693353512 MirTarget;miRNATAP -0.17218937101763 1.35434055056965e-08 NA NA NA hsa-miR-148b-3p GADD45A 1.97815018171325 6.07715327281595e-26 -0.835839078652441 0.000140836693353512 MirTarget -0.24164313540326 6.68989940877406e-06 NA NA NA hsa-miR-301a-3p GADD45A 2.81024345929638 2.29784847962242e-17 -0.835839078652441 0.000140836693353512 MirTarget;miRNATAP -0.112998413130989 0.000548458732723422 NA NA NA hsa-miR-324-5p GADD45A 2.95683728155095 1.32960514360912e-20 -0.835839078652441 0.000140836693353512 miRanda -0.112457495567732 0.000439233642516274 NA NA NA hsa-miR-421 GADD45A 1.17791565395543 6.78526676976629e-06 -0.835839078652441 0.000140836693353512 miRanda -0.133567846694638 0.00100215803079645 NA NA NA hsa-miR-454-3p GADD45A 2.47234127820054 1.12878018736016e-21 -0.835839078652441 0.000140836693353512 MirTarget;miRNATAP -0.123232081874385 0.00233561552908576 NA NA NA hsa-miR-590-3p GADD45A 2.59289455139753 1.03200520972022e-21 -0.835839078652441 0.000140836693353512 miRanda;mirMAP -0.116878603221423 0.00246827969058347 NA NA NA hsa-miR-1976 GADD45B 2.06550563678192 7.81396978619772e-18 -2.10522351126521 1.24009438337654e-11 miRNATAP -0.438571553390836 3.56919131064351e-13 NA NA NA hsa-miR-324-3p GADD45B 2.08739139768981 3.11885987067952e-13 -2.10522351126521 1.24009438337654e-11 MirTarget;miRNATAP -0.529388083839586 5.82182378729412e-27 NA NA NA hsa-miR-590-3p GADD45B 2.59289455139753 1.03200520972022e-21 -2.10522351126521 1.24009438337654e-11 miRanda -0.441564740260131 2.37587329223105e-16 NA NA NA hsa-let-7a-3p GAS1 1.42015538786275 7.03375209382654e-13 -2.1882386842391 0.000375177981793486 miRNATAP -0.563628789350354 0.000141323121330898 NA NA NA hsa-miR-129-5p GAS1 -0.524170159980738 0.222582956006346 -2.1882386842391 0.000375177981793486 miRanda -0.29558826069247 2.87622700214878e-05 NA NA NA hsa-miR-130b-3p GAS1 3.5350292994509 1.73934183852569e-27 -2.1882386842391 0.000375177981793486 miRNAWalker2_validate -0.646310361223317 1.10443776266471e-14 NA NA NA hsa-miR-183-5p GAS1 4.19757025992371 4.79612296318304e-26 -2.1882386842391 0.000375177981793486 miRNAWalker2_validate -0.693742196979546 2.51632530581404e-25 NA NA NA hsa-miR-186-5p GAS1 1.47445398888668 3.0781726595413e-15 -2.1882386842391 0.000375177981793486 mirMAP -1.17892578251583 8.42526865996136e-15 NA NA NA hsa-miR-26b-3p GAS1 2.18464160365372 2.11543189388328e-18 -2.1882386842391 0.000375177981793486 MirTarget -1.04328602278381 2.68193011857425e-21 NA NA NA hsa-miR-32-3p GAS1 2.02436999565685 5.94091197945307e-09 -2.1882386842391 0.000375177981793486 mirMAP -0.75396641175105 6.72648305751722e-16 NA NA NA hsa-miR-33a-5p GAS1 3.79671563098419 1.15966309820345e-18 -2.1882386842391 0.000375177981793486 miRNATAP -0.587958665051679 4.0499889337707e-17 NA NA NA hsa-miR-34a-5p GAS1 1.9016323452565 1.43092834643601e-14 -2.1882386842391 0.000375177981793486 miRNAWalker2_validate;miRNATAP -0.926566103710993 4.11296403810168e-16 24220341 MiR 34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway; Both miR-34a and GAS1 are frequently down-regulated in various tumors; However it has been reported that while GAS1 is down-regulated in papillary thyroid carcinoma PTC miR-34a is up-regulated in this specific type of cancer although their potential roles in PTC tumorigenesis have not been examined to date; A computational search revealed that miR-34a putatively binds to the 3'-UTR of GAS1 gene; In the present study we confirmed previous findings that miR-34a is up-regulated and GAS1 down-regulated in PTC tissues; Further studies indicated that GAS1 is directly targeted by miR-34a; Silencing of GAS1 had similar growth-promoting effects as overexpression of miR-34a; Taken together our results demonstrate that miR-34a regulates GAS1 expression to promote proliferation and suppress apoptosis in PTC cells via PI3K/Akt/Bad pathway tumorigenesis thyroid cancer hsa-miR-3607-3p GAS1 2.68532138541128 5.66716351955047e-14 -2.1882386842391 0.000375177981793486 MirTarget -0.632206260475355 5.69380348463648e-15 NA NA NA hsa-miR-486-5p GAS1 -0.194913133034028 0.607377798807705 -2.1882386842391 0.000375177981793486 miRanda -0.37683253103161 1.50499202341399e-06 NA NA NA hsa-miR-582-3p GAS1 0.00876844181512659 0.977126166214707 -2.1882386842391 0.000375177981793486 PITA;miRNATAP -0.704432421532796 1.77184171123458e-13 NA NA NA hsa-miR-625-5p GAS1 1.42540152147292 1.95797147911206e-06 -2.1882386842391 0.000375177981793486 MirTarget -0.328310111684979 0.00253314990828728 NA NA NA hsa-miR-944 GAS1 2.91186649218281 1.31574753528144e-06 -2.1882386842391 0.000375177981793486 PITA;miRNATAP -0.383322721992951 6.02994172598408e-15 NA NA NA hsa-miR-141-3p GEM 5.02396127982626 2.19224509139725e-24 -3.69134770515528 5.61525969896728e-16 MirTarget -0.587565485490449 1.27714231653948e-52 NA NA NA hsa-miR-200a-3p GEM 4.59434485520731 6.38952518573476e-18 -3.69134770515528 5.61525969896728e-16 MirTarget -0.4889443383683 6.54105284167297e-39 NA NA NA hsa-miR-200b-3p GEM 3.78235093249346 3.18343003239465e-14 -3.69134770515528 5.61525969896728e-16 MirTarget -0.485634556765837 3.95896854070478e-32 NA NA NA hsa-miR-200c-3p GEM 3.50132673580082 2.42716349086937e-15 -3.69134770515528 5.61525969896728e-16 MirTarget;miRNATAP -0.59591901710192 2.64134984555771e-39 NA NA NA hsa-miR-224-3p GEM 1.87536386559317 6.15140969394846e-05 -3.69134770515528 5.61525969896728e-16 MirTarget -0.293569943550344 4.20313745280062e-09 NA NA NA hsa-miR-26b-5p GEM 0.885393662798425 3.2116297961629e-06 -3.69134770515528 5.61525969896728e-16 miRNAWalker2_validate -0.953960416084034 2.41319782008023e-16 NA NA NA hsa-miR-335-5p GEM 1.77247705492746 2.22457658872091e-06 -3.69134770515528 5.61525969896728e-16 miRNAWalker2_validate -0.311549047445268 1.79609781271512e-07 NA NA NA hsa-miR-361-5p GEM 0.971859117235239 5.30236555707088e-09 -3.69134770515528 5.61525969896728e-16 miRanda -1.37225876308426 2.21766741397673e-26 NA NA NA hsa-miR-429 GEM 4.48815175680773 2.44117492218206e-17 -3.69134770515528 5.61525969896728e-16 MirTarget;PITA;miRanda;miRNATAP -0.460931181453638 2.00254563600948e-33 NA NA NA hsa-miR-590-3p GEM 2.59289455139753 1.03200520972022e-21 -3.69134770515528 5.61525969896728e-16 miRanda -0.722743545915414 7.13291905494987e-20 NA NA NA hsa-miR-625-5p GEM 1.42540152147292 1.95797147911206e-06 -3.69134770515528 5.61525969896728e-16 MirTarget -0.39117310065775 2.07531746349635e-06 NA NA NA hsa-miR-101-3p GJA1 0.522819989585461 0.00375627731618038 -1.07233368590878 0.00281552609103631 MirTarget;miRNATAP -0.255210348136167 0.00900080663130644 NA NA NA hsa-miR-142-3p GJA1 2.75247908790621 1.45636065474764e-12 -1.07233368590878 0.00281552609103631 miRanda -0.118345211391414 0.00663717991861936 NA NA NA hsa-miR-148b-5p GJA1 2.18024067300781 2.84770452413262e-14 -1.07233368590878 0.00281552609103631 MirTarget -0.18540415241077 0.00297394693599943 NA NA NA hsa-miR-17-5p GJA1 3.2710598467455 9.93128340539455e-27 -1.07233368590878 0.00281552609103631 TargetScan -0.211012328252669 7.5815703019124e-05 NA NA NA hsa-miR-185-5p GJA1 2.34016206907488 1.17481626642022e-26 -1.07233368590878 0.00281552609103631 MirTarget -0.207562206689894 0.00577558738052974 NA NA NA hsa-miR-186-5p GJA1 1.47445398888668 3.0781726595413e-15 -1.07233368590878 0.00281552609103631 MirTarget;miRNATAP -0.357424045103603 8.18841838907159e-05 NA NA NA hsa-miR-193a-3p GJA1 1.60460546928078 2.86169793322984e-07 -1.07233368590878 0.00281552609103631 miRanda -0.172854673914459 0.00167597379920211 NA NA NA hsa-miR-19a-3p GJA1 3.42309334186656 3.02671914353412e-28 -1.07233368590878 0.00281552609103631 MirTarget;miRNATAP -0.252467712630339 1.21229412427207e-06 NA NA NA hsa-miR-19b-3p GJA1 2.49529833021187 1.57028265846699e-23 -1.07233368590878 0.00281552609103631 MirTarget;miRNATAP -0.312808765804345 1.96234608805332e-06 NA NA NA hsa-miR-301a-3p GJA1 2.81024345929638 2.29784847962242e-17 -1.07233368590878 0.00281552609103631 MirTarget;miRNATAP -0.187081304576645 0.000451684236210235 NA NA NA hsa-miR-30b-5p GJA1 0.800822374912712 0.000133601914525413 -1.07233368590878 0.00281552609103631 MirTarget;mirMAP -0.256304595355134 0.00207440403392586 NA NA NA hsa-miR-30c-5p GJA1 0.778774633108 0.000285599212429136 -1.07233368590878 0.00281552609103631 MirTarget;mirMAP;miRNATAP -0.260232847367055 0.00136533615953117 NA NA NA hsa-miR-30d-3p GJA1 0.977747550180601 4.3048212205381e-05 -1.07233368590878 0.00281552609103631 MirTarget -0.192822928495618 0.00815044508188232 NA NA NA hsa-miR-30d-5p GJA1 0.675423997639582 0.00270618816039773 -1.07233368590878 0.00281552609103631 MirTarget;mirMAP;miRNATAP -0.241752424452621 0.00183618727367943 NA NA NA hsa-miR-30e-5p GJA1 1.23904909539663 1.35561917122157e-09 -1.07233368590878 0.00281552609103631 MirTarget -0.360412144766873 1.72261892641393e-05 NA NA NA hsa-miR-342-3p GJA1 1.49115144672245 1.43879249744621e-07 -1.07233368590878 0.00281552609103631 miRNAWalker2_validate;miRNATAP -0.268365929842058 8.70266398671555e-06 NA NA NA hsa-miR-454-3p GJA1 2.47234127820054 1.12878018736016e-21 -1.07233368590878 0.00281552609103631 MirTarget;miRNATAP -0.325765121671534 6.44221558287458e-07 NA NA NA hsa-miR-576-5p GJA1 2.20467023993664 3.4053475193793e-19 -1.07233368590878 0.00281552609103631 PITA;mirMAP -0.282494944566365 2.96419214288726e-05 NA NA NA hsa-miR-590-3p GJA1 2.59289455139753 1.03200520972022e-21 -1.07233368590878 0.00281552609103631 PITA;miRanda -0.242180507604328 0.000114388118189938 NA NA NA hsa-miR-7-1-3p GJA1 1.84950311431067 1.25300363397654e-13 -1.07233368590878 0.00281552609103631 mirMAP -0.21224471023301 0.00180298702390423 NA NA NA hsa-let-7d-3p GLIPR1 0.837345596411224 1.39469480391458e-05 -1.33750196699046 8.61857160192238e-05 MirTarget -0.609429422015334 4.23699551395864e-13 NA NA NA hsa-miR-107 GLIPR1 1.30977326593435 1.30372468603965e-11 -1.33750196699046 8.61857160192238e-05 miRanda -0.696399872278751 1.20273921608504e-17 NA NA NA hsa-miR-1226-3p GLIPR1 1.38118928579963 0.000205503474787488 -1.33750196699046 8.61857160192238e-05 MirTarget -0.431694970186888 7.61229680812077e-19 NA NA NA hsa-miR-129-5p GLIPR1 -0.524170159980738 0.222582956006346 -1.33750196699046 8.61857160192238e-05 miRanda -0.121987806306643 0.00193561402495794 NA NA NA hsa-miR-148b-5p GLIPR1 2.18024067300781 2.84770452413262e-14 -1.33750196699046 8.61857160192238e-05 mirMAP -0.453601414845121 3.52239733669453e-15 NA NA NA hsa-miR-149-5p GLIPR1 2.94200492826326 4.93436498919036e-14 -1.33750196699046 8.61857160192238e-05 MirTarget -0.354189710699369 2.85710376398971e-19 NA NA NA hsa-miR-16-2-3p GLIPR1 2.31623086727196 4.29838149388188e-20 -1.33750196699046 8.61857160192238e-05 mirMAP -0.295515559370233 2.27677755386166e-06 NA NA NA hsa-miR-19a-3p GLIPR1 3.42309334186656 3.02671914353412e-28 -1.33750196699046 8.61857160192238e-05 mirMAP -0.273826774449191 2.84753971813974e-08 NA NA NA hsa-miR-19b-3p GLIPR1 2.49529833021187 1.57028265846699e-23 -1.33750196699046 8.61857160192238e-05 mirMAP -0.413518728116259 2.25043460903556e-11 NA NA NA hsa-miR-20a-3p GLIPR1 2.92621109947706 2.49504904635375e-17 -1.33750196699046 8.61857160192238e-05 mirMAP -0.303460101326909 6.7296191617022e-11 NA NA NA hsa-miR-23b-3p GLIPR1 -0.251132426825047 0.150200321210792 -1.33750196699046 8.61857160192238e-05 mirMAP -0.327810081130433 0.000673811398931534 NA NA NA hsa-miR-26b-3p GLIPR1 2.18464160365372 2.11543189388328e-18 -1.33750196699046 8.61857160192238e-05 mirMAP -0.407601966220231 8.19920369428276e-11 NA NA NA hsa-miR-28-5p GLIPR1 0.230152919654905 0.0742909586754846 -1.33750196699046 8.61857160192238e-05 miRanda -0.44988088681852 0.000695906677398546 NA NA NA hsa-miR-30d-3p GLIPR1 0.977747550180601 4.3048212205381e-05 -1.33750196699046 8.61857160192238e-05 mirMAP -0.699798035111271 7.12250781861856e-27 NA NA NA hsa-miR-30e-3p GLIPR1 -0.215663037684509 0.235375122783546 -1.33750196699046 8.61857160192238e-05 mirMAP -0.711539862602377 2.23112832946127e-15 NA NA NA hsa-miR-320a GLIPR1 0.438165828017084 0.0390159073347133 -1.33750196699046 8.61857160192238e-05 mirMAP -0.431206350868528 2.94714338991158e-08 NA NA NA hsa-miR-330-3p GLIPR1 0.876747334239085 0.00073709016089703 -1.33750196699046 8.61857160192238e-05 PITA -0.504128167886196 3.09172323560559e-16 NA NA NA hsa-miR-335-3p GLIPR1 3.08791651139852 5.31309869723517e-12 -1.33750196699046 8.61857160192238e-05 mirMAP -0.26501400439444 3.97382892097937e-14 NA NA NA hsa-miR-361-5p GLIPR1 0.971859117235239 5.30236555707088e-09 -1.33750196699046 8.61857160192238e-05 MirTarget;miRanda;mirMAP -0.845650501115035 8.71022183909848e-19 NA NA NA hsa-miR-584-5p GLIPR1 2.7326672683732 9.92677936962233e-12 -1.33750196699046 8.61857160192238e-05 mirMAP -0.262397837353427 2.86494732024172e-11 NA NA NA hsa-miR-590-3p GLIPR1 2.59289455139753 1.03200520972022e-21 -1.33750196699046 8.61857160192238e-05 PITA;miRanda;mirMAP -0.247537467571535 3.38887000878312e-05 NA NA NA hsa-miR-877-5p GLIPR1 2.94916202082736 1.8151927276044e-13 -1.33750196699046 8.61857160192238e-05 MirTarget -0.291373244008302 5.49665414635572e-11 NA NA NA hsa-miR-9-5p GLIPR1 1.02304182473283 0.042901377604859 -1.33750196699046 8.61857160192238e-05 mirMAP -0.121829359360515 0.000189806127612364 NA NA NA hsa-miR-942-5p GLIPR1 2.35195531153712 5.45059325728841e-16 -1.33750196699046 8.61857160192238e-05 MirTarget -0.232157270328879 2.38341789045781e-05 NA NA NA hsa-miR-944 GLIPR1 2.91186649218281 1.31574753528144e-06 -1.33750196699046 8.61857160192238e-05 PITA -0.137044761435603 8.36423988505205e-07 NA NA NA hsa-miR-1226-3p GPC1 1.38118928579963 0.000205503474787488 0.184834746071041 0.52367350175098 MirTarget -0.121953301191575 0.0043612621300946 NA NA NA hsa-miR-3200-3p GPC1 2.70510522077868 1.90469509928484e-08 0.184834746071041 0.52367350175098 mirMAP -0.106679161259389 0.000426958015745072 NA NA NA hsa-miR-326 GPC1 0.715313016136042 0.0610265683213359 0.184834746071041 0.52367350175098 mirMAP -0.189786614849216 1.8383053800523e-07 NA NA NA hsa-let-7f-5p GPX7 0.495648727272215 0.00355972741198794 -0.0292022974781792 0.922145587159984 miRNATAP -0.234342962118826 0.00641371867255879 NA NA NA hsa-let-7g-5p GPX7 1.20061455355116 1.50237505511483e-12 -0.0292022974781792 0.922145587159984 miRNATAP -0.36977889364494 9.30362398626483e-06 NA NA NA hsa-miR-29b-3p GPX7 1.65828197923813 1.02676780888141e-09 -0.0292022974781792 0.922145587159984 MirTarget;miRNATAP -0.246667176200296 1.90428330444207e-06 NA NA NA hsa-miR-29c-3p GPX7 -0.00968972577705429 0.97099586346872 -0.0292022974781792 0.922145587159984 MirTarget;miRNATAP -0.238702206767888 1.01092826097694e-05 NA NA NA hsa-miR-429 GPX7 4.48815175680773 2.44117492218206e-17 -0.0292022974781792 0.922145587159984 miRNATAP -0.120454824625265 3.29069197238318e-06 NA NA NA hsa-miR-107 GREM1 1.30977326593435 1.30372468603965e-11 0.08752650759248 0.914525538097529 miRanda -1.37810741656521 2.02758217319007e-12 NA NA NA hsa-miR-10b-3p GREM1 0.77597971642517 0.00264877454133753 0.08752650759248 0.914525538097529 MirTarget -1.36852159609299 6.23271757645556e-21 NA NA NA hsa-miR-128-3p GREM1 1.63756041666078 6.79626586407187e-14 0.08752650759248 0.914525538097529 MirTarget -1.13422279076679 4.85325219373668e-11 NA NA NA hsa-miR-129-5p GREM1 -0.524170159980738 0.222582956006346 0.08752650759248 0.914525538097529 mirMAP -0.471227080343252 3.52117281319331e-07 NA NA NA hsa-miR-151a-3p GREM1 1.24018761527407 1.08839919675408e-07 0.08752650759248 0.914525538097529 MirTarget -1.58222563926787 2.02841814242008e-23 NA NA NA hsa-miR-15b-3p GREM1 2.33847028227712 4.29662877950836e-19 0.08752650759248 0.914525538097529 mirMAP -0.819842990848174 8.43287080175706e-09 NA NA NA hsa-miR-181c-5p GREM1 1.58587920618301 1.57506918816933e-10 0.08752650759248 0.914525538097529 MirTarget -0.503571678139943 0.00124981890133994 NA NA NA hsa-miR-181d-5p GREM1 1.52204912185579 9.2693319057748e-08 0.08752650759248 0.914525538097529 MirTarget -0.447647485490356 0.00104202641429586 NA NA NA hsa-miR-186-5p GREM1 1.47445398888668 3.0781726595413e-15 0.08752650759248 0.914525538097529 mirMAP -1.09586475549989 7.29953165734902e-08 NA NA NA hsa-miR-200b-3p GREM1 3.78235093249346 3.18343003239465e-14 0.08752650759248 0.914525538097529 MirTarget -0.579405660626665 5.36921677424216e-15 NA NA NA hsa-miR-200c-3p GREM1 3.50132673580082 2.42716349086937e-15 0.08752650759248 0.914525538097529 MirTarget -0.651094007307394 5.51115376486247e-15 NA NA NA hsa-miR-30d-3p GREM1 0.977747550180601 4.3048212205381e-05 0.08752650759248 0.914525538097529 MirTarget -1.52172277523851 2.57374182547526e-22 NA NA NA hsa-miR-30e-3p GREM1 -0.215663037684509 0.235375122783546 0.08752650759248 0.914525538097529 MirTarget -1.87248543784311 7.38237263621522e-19 NA NA NA hsa-miR-32-3p GREM1 2.02436999565685 5.94091197945307e-09 0.08752650759248 0.914525538097529 mirMAP -0.811892755821005 6.93218407387058e-11 NA NA NA hsa-miR-330-3p GREM1 0.876747334239085 0.00073709016089703 0.08752650759248 0.914525538097529 mirMAP -1.05010076920601 1.23653879596895e-12 NA NA NA hsa-miR-3653-3p GREM1 1.85886928622326 2.98407490336841e-08 0.08752650759248 0.914525538097529 MirTarget -0.528754440768381 1.39914241513161e-05 NA NA NA hsa-miR-429 GREM1 4.48815175680773 2.44117492218206e-17 0.08752650759248 0.914525538097529 MirTarget;miRanda -0.503437531755623 4.25141486107767e-13 NA NA NA hsa-miR-484 GREM1 1.81844463411787 1.82951571230938e-15 0.08752650759248 0.914525538097529 PITA -0.772943992081722 3.27500357761039e-06 NA NA NA hsa-miR-576-5p GREM1 2.20467023993664 3.4053475193793e-19 0.08752650759248 0.914525538097529 mirMAP -0.586644183254509 0.000128451300339467 NA NA NA hsa-miR-664a-3p GREM1 0.634721925861133 0.00520070178640421 0.08752650759248 0.914525538097529 mirMAP -1.25554376789919 1.28137929925914e-13 NA NA NA hsa-miR-944 GREM1 2.91186649218281 1.31574753528144e-06 0.08752650759248 0.914525538097529 mirMAP -0.306629317082103 3.55297790645169e-06 NA NA NA hsa-miR-129-5p HTRA1 -0.524170159980738 0.222582956006346 -0.897189474957641 0.00608569106281965 MirTarget;miRanda -0.126271244329874 0.000776610395771909 NA NA NA hsa-miR-16-5p HTRA1 1.75824877145857 1.68592440033108e-16 -0.897189474957641 0.00608569106281965 miRNAWalker2_validate -0.601255357179025 4.67757906860409e-18 NA NA NA hsa-miR-181a-2-3p HTRA1 2.19062681262366 3.81790102612782e-13 -0.897189474957641 0.00608569106281965 MirTarget -0.171032759779745 0.000813972464760206 NA NA NA hsa-miR-26b-5p HTRA1 0.885393662798425 3.2116297961629e-06 -0.897189474957641 0.00608569106281965 miRNAWalker2_validate -0.43944641232857 1.00437528975115e-07 NA NA NA hsa-let-7a-3p ID2 1.42015538786275 7.03375209382654e-13 -1.54654357209616 1.27444108702092e-06 miRNATAP -0.358646681831114 3.17261659036183e-06 NA NA NA hsa-let-7b-3p ID2 0.868207752019623 1.30460056774366e-05 -1.54654357209616 1.27444108702092e-06 miRNATAP -0.283914204742337 0.000289181687117768 NA NA NA hsa-miR-19a-3p ID2 3.42309334186656 3.02671914353412e-28 -1.54654357209616 1.27444108702092e-06 MirTarget;miRNATAP -0.16516373144464 0.000436575283437063 NA NA NA hsa-miR-19b-3p ID2 2.49529833021187 1.57028265846699e-23 -1.54654357209616 1.27444108702092e-06 MirTarget;miRNATAP -0.157910549016721 0.0079766133260792 NA NA NA hsa-miR-27a-3p ID2 1.66542180327138 4.93775737894805e-13 -1.54654357209616 1.27444108702092e-06 MirTarget;miRNATAP -0.415869746928321 1.64119825970062e-10 NA NA NA hsa-miR-338-3p ID2 0.453166438193782 0.144583389707558 -1.54654357209616 1.27444108702092e-06 miRanda -0.150326580770318 0.00285978135046781 NA NA NA hsa-miR-455-3p ID2 3.06093594997644 3.54590649799868e-16 -1.54654357209616 1.27444108702092e-06 MirTarget;PITA;miRNATAP -0.212973966922076 7.67722071909368e-08 NA NA NA hsa-miR-590-3p ID2 2.59289455139753 1.03200520972022e-21 -1.54654357209616 1.27444108702092e-06 miRanda -0.168489146813562 0.00286466301670518 NA NA NA hsa-miR-9-5p ID2 1.02304182473283 0.042901377604859 -1.54654357209616 1.27444108702092e-06 miRNAWalker2_validate;miRTarBase -0.114949551075085 0.000184259502532564 NA NA NA hsa-miR-193a-3p IGFBP2 1.60460546928078 2.86169793322984e-07 -1.5968070360761 0.000610829805706469 miRanda -0.37205079579232 1.48066193437294e-07 NA NA NA hsa-miR-340-5p IGFBP3 0.30282999308409 0.157744789519131 1.07616866066205 0.0190221889164414 MirTarget -0.363812620560802 0.000495010806414192 NA NA NA hsa-miR-326 IGFBP4 0.715313016136042 0.0610265683213359 -0.69029477845298 0.0129459532374433 MirTarget;miRanda -0.108661704481173 0.00211769323536632 NA NA NA hsa-miR-330-5p IGFBP4 1.15100069700871 4.85551805046014e-07 -0.69029477845298 0.0129459532374433 MirTarget;miRanda -0.190113591682734 0.00112492985931617 NA NA NA hsa-miR-362-3p IGFBP4 2.0756816987665 3.89026064579331e-12 -0.69029477845298 0.0129459532374433 miRanda -0.240744896778299 7.95760749022021e-08 NA NA NA hsa-miR-375 IGFBP4 1.13910305294079 0.0512283522214186 -0.69029477845298 0.0129459532374433 miRanda -0.196394122600547 4.66836537136259e-19 NA NA NA hsa-miR-491-5p IGFBP4 0.615770352820862 0.0418295628761654 -0.69029477845298 0.0129459532374433 miRanda -0.174568529024333 0.000246039693858837 NA NA NA hsa-miR-532-3p IGFBP4 1.96631878320218 4.53421954361695e-13 -0.69029477845298 0.0129459532374433 miRNATAP -0.346409175981139 1.70269535990727e-13 NA NA NA hsa-miR-7-5p IGFBP4 2.28980165299999 1.5131097560452e-07 -0.69029477845298 0.0129459532374433 miRNAWalker2_validate -0.208441125448064 8.40707849544873e-11 NA NA NA hsa-miR-107 IL15 1.30977326593435 1.30372468603965e-11 -0.561691313915147 0.104404851611327 miRanda;miRNATAP -0.393903497926685 3.18868351861918e-06 NA NA NA hsa-miR-130b-3p IL15 3.5350292994509 1.73934183852569e-27 -0.561691313915147 0.104404851611327 MirTarget -0.287552944203805 1.26152640675242e-09 NA NA NA hsa-miR-148b-3p IL15 1.97815018171325 6.07715327281595e-26 -0.561691313915147 0.104404851611327 MirTarget -0.38814129011701 3.80445504519875e-06 NA NA NA hsa-miR-192-5p IL15 2.69002528723195 1.22990188194432e-16 -0.561691313915147 0.104404851611327 miRNAWalker2_validate -0.266042590627927 5.65339321908063e-08 NA NA NA hsa-miR-215-5p IL15 2.30755467422978 2.38476032118039e-06 -0.561691313915147 0.104404851611327 miRNAWalker2_validate -0.145534278747456 2.60665414172521e-05 NA NA NA hsa-miR-301a-3p IL15 2.81024345929638 2.29784847962242e-17 -0.561691313915147 0.104404851611327 MirTarget -0.187676228907966 0.000244115335167079 NA NA NA hsa-miR-3065-5p IL15 2.74629919868982 1.86846589298284e-08 -0.561691313915147 0.104404851611327 mirMAP -0.109630268085725 0.00793491196058695 NA NA NA hsa-miR-324-5p IL15 2.95683728155095 1.32960514360912e-20 -0.561691313915147 0.104404851611327 miRanda -0.191230627368865 0.000132351815883966 NA NA NA hsa-miR-429 IL15 4.48815175680773 2.44117492218206e-17 -0.561691313915147 0.104404851611327 miRanda -0.260013704694446 3.28859887667923e-19 NA NA NA hsa-miR-450b-5p IL15 1.69244418548325 1.68064054148881e-10 -0.561691313915147 0.104404851611327 MirTarget -0.25182345817763 4.45681905000812e-05 NA NA NA hsa-miR-542-3p IL15 1.18832665895751 1.98700670691565e-07 -0.561691313915147 0.104404851611327 miRanda -0.236491799661947 0.00111813079715954 NA NA NA hsa-miR-98-5p IL32 1.11154309866014 1.24143909012085e-08 0.579375154427283 0.182409810976428 miRNAWalker2_validate -0.648549642556284 6.72189554365925e-10 NA NA NA hsa-let-7a-5p IL6 0.618599506841644 2.76973453058748e-05 -4.51457391074354 1.84664878324708e-10 miRNAWalker2_validate -1.49764192032347 2.38346175895915e-10 21352471;23977098 Knocking down IL-6 and Twist in HSCs significantly reduced let-7 and miR-181 expression and subsequently inhibited chemoresistance and cell invasion;Loss of let 7 microRNA upregulates IL 6 in bone marrow derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer; We also found that IL-6 is a direct target gene for the let-7 microRNA which was downregulated in cancer-associated MSCs; The overexpression of let-7 via the transfection of let-7 precursors decreased IL-6 expression and repressed the adipogenic potential and metastasis-promoting activity of cancer-associated MSCs which was consistent with the inhibition of IL-6 3'UTR luciferase activity; Conversely the treatment of normal MSCs with let-7 inhibitors resulted in effects similar to those seen with IL-6; Taken together our data demonstrated that MSCs co-evolve with prostate cancer cells in the tumor microenvironment and the downregulation of let-7 by cancer-associated MSCs upregulates IL-6 expression drug resistance;drug resistance;metastasis liver cancer;prostate cancer hsa-miR-107 IL6 1.30977326593435 1.30372468603965e-11 -4.51457391074354 1.84664878324708e-10 miRanda -1.33183779333917 1.54734218444571e-14 NA NA NA hsa-miR-335-5p IL6 1.77247705492746 2.22457658872091e-06 -4.51457391074354 1.84664878324708e-10 miRNAWalker2_validate -0.467167119193204 3.30170788121676e-07 NA NA NA hsa-miR-361-5p IL6 0.971859117235239 5.30236555707088e-09 -4.51457391074354 1.84664878324708e-10 miRanda -1.82491350948499 1.24082346226555e-19 NA NA NA hsa-miR-429 IL6 4.48815175680773 2.44117492218206e-17 -4.51457391074354 1.84664878324708e-10 miRanda -0.671855968964194 6.61057721414734e-30 NA NA NA hsa-miR-98-5p IL6 1.11154309866014 1.24143909012085e-08 -4.51457391074354 1.84664878324708e-10 miRNAWalker2_validate -1.23406095672236 1.33158050901419e-12 25277211 miR 98 suppresses melanoma metastasis through a negative feedback loop with its target gene IL 6; We also found that IL-6 is a target gene of miR-98 and IL-6 represses miR-98 levels via the Stat3-NF-κB-lin28B pathway metastasis melanoma hsa-miR-10b-5p INHBA -0.155951595811628 0.555006386998027 1.44116109080829 0.0141935130251973 miRNAWalker2_validate -0.806261626502605 1.88811148190204e-14 NA NA NA hsa-miR-129-5p INHBA -0.524170159980738 0.222582956006346 1.44116109080829 0.0141935130251973 miRanda -0.217462863610452 0.00127865658512647 NA NA NA hsa-miR-148b-3p INHBA 1.97815018171325 6.07715327281595e-26 1.44116109080829 0.0141935130251973 miRNAWalker2_validate -0.815256633903519 9.54994164398835e-09 NA NA NA hsa-miR-181c-5p INHBA 1.58587920618301 1.57506918816933e-10 1.44116109080829 0.0141935130251973 mirMAP -0.484134229816087 1.62177913258834e-05 NA NA NA hsa-miR-200b-3p INHBA 3.78235093249346 3.18343003239465e-14 1.44116109080829 0.0141935130251973 TargetScan -0.408352816068364 2.84386065824124e-14 NA NA NA hsa-miR-224-3p INHBA 1.87536386559317 6.15140969394846e-05 1.44116109080829 0.0141935130251973 mirMAP -0.25047555438214 6.84234124400527e-05 NA NA NA hsa-miR-23b-3p INHBA -0.251132426825047 0.150200321210792 1.44116109080829 0.0141935130251973 mirMAP -0.516405683758728 0.00182807381264671 NA NA NA hsa-miR-26b-5p INHBA 0.885393662798425 3.2116297961629e-06 1.44116109080829 0.0141935130251973 mirMAP -0.478405936924044 0.00140500867887125 NA NA NA hsa-miR-30b-5p INHBA 0.800822374912712 0.000133601914525413 1.44116109080829 0.0141935130251973 mirMAP -0.908128346719846 9.11214995758966e-12 NA NA NA hsa-miR-30c-5p INHBA 0.778774633108 0.000285599212429136 1.44116109080829 0.0141935130251973 mirMAP -1.1265541412423 1.16435194721796e-18 NA NA NA hsa-miR-30d-5p INHBA 0.675423997639582 0.00270618816039773 1.44116109080829 0.0141935130251973 mirMAP -1.28724105324569 3.72358672438813e-27 NA NA NA hsa-miR-30e-5p INHBA 1.23904909539663 1.35561917122157e-09 1.44116109080829 0.0141935130251973 mirMAP -1.37027336840008 5.34980288081758e-26 NA NA NA hsa-miR-3607-3p INHBA 2.68532138541128 5.66716351955047e-14 1.44116109080829 0.0141935130251973 mirMAP -0.274602968013892 0.000530682371959114 NA NA NA hsa-miR-421 INHBA 1.17791565395543 6.78526676976629e-06 1.44116109080829 0.0141935130251973 miRanda -0.280376056517452 0.00980185971427785 NA NA NA hsa-miR-664a-3p INHBA 0.634721925861133 0.00520070178640421 1.44116109080829 0.0141935130251973 mirMAP -1.09887225313958 7.9941479643233e-20 NA NA NA hsa-miR-944 INHBA 2.91186649218281 1.31574753528144e-06 1.44116109080829 0.0141935130251973 mirMAP -0.128642141599637 0.00765396161708449 NA NA NA hsa-miR-103a-3p ITGA2 1.44083190496858 1.53799939616416e-13 0.780933228446094 0.0360115182087058 miRNAWalker2_validate;MirTarget;miRNATAP -0.259499020989338 0.00419323029610024 NA NA NA hsa-miR-107 ITGA2 1.30977326593435 1.30372468603965e-11 0.780933228446094 0.0360115182087058 MirTarget;miRanda;miRNATAP -0.262580981852226 0.00426625602830046 NA NA NA hsa-miR-139-5p ITGA2 -1.52606598644743 1.20474151350665e-08 0.780933228446094 0.0360115182087058 PITA;miRanda -0.249459221893773 0.000164230962733441 NA NA NA hsa-miR-186-5p ITGA2 1.47445398888668 3.0781726595413e-15 0.780933228446094 0.0360115182087058 mirMAP -0.270901743611912 0.00407079218140721 NA NA NA hsa-miR-195-5p ITGA2 -1.44753678070504 8.70594292149271e-09 0.780933228446094 0.0360115182087058 MirTarget;miRNATAP -0.291851965767148 3.37825228491837e-05 NA NA NA hsa-miR-301a-3p ITGA2 2.81024345929638 2.29784847962242e-17 0.780933228446094 0.0360115182087058 mirMAP -0.143921799403505 0.00934010376589392 NA NA NA hsa-miR-30b-5p ITGA2 0.800822374912712 0.000133601914525413 0.780933228446094 0.0360115182087058 mirMAP -0.261141707592115 0.00243365828617581 NA NA NA hsa-miR-30c-5p ITGA2 0.778774633108 0.000285599212429136 0.780933228446094 0.0360115182087058 mirMAP -0.357208346841337 1.97878207915458e-05 NA NA NA hsa-miR-30d-5p ITGA2 0.675423997639582 0.00270618816039773 0.780933228446094 0.0360115182087058 mirMAP -0.275205640738548 0.000600053227514717 NA NA NA hsa-miR-30e-5p ITGA2 1.23904909539663 1.35561917122157e-09 0.780933228446094 0.0360115182087058 mirMAP -0.385351859813687 8.81532571140156e-06 NA NA NA hsa-miR-326 ITGA2 0.715313016136042 0.0610265683213359 0.780933228446094 0.0360115182087058 PITA -0.197349558072418 2.85604059843187e-05 NA NA NA hsa-miR-362-3p ITGA2 2.0756816987665 3.89026064579331e-12 0.780933228446094 0.0360115182087058 miRanda -0.176732413381176 0.00366766434646306 NA NA NA hsa-miR-374b-5p ITGA2 0.0654362503857184 0.722673188879465 0.780933228446094 0.0360115182087058 MirTarget -0.354406420781692 0.000343325697020091 NA NA NA hsa-miR-497-5p ITGA2 0.0257087130056286 0.918145413833358 0.780933228446094 0.0360115182087058 MirTarget;miRNATAP -0.366207967257797 3.40827962148287e-07 NA NA NA hsa-miR-532-5p ITGA2 1.55697650978597 1.57884735535196e-11 0.780933228446094 0.0360115182087058 MirTarget -0.332666665896713 1.25051690707039e-05 NA NA NA hsa-miR-664a-3p ITGA2 0.634721925861133 0.00520070178640421 0.780933228446094 0.0360115182087058 MirTarget;mirMAP -0.307064501532047 0.000110039333374447 NA NA NA hsa-miR-93-3p ITGA2 2.85383869771942 5.64481766902125e-23 0.780933228446094 0.0360115182087058 MirTarget -0.190076957794452 0.00130315247637948 NA NA NA hsa-miR-107 ITGA5 1.30977326593435 1.30372468603965e-11 -2.12715698251452 2.02033561007737e-09 PITA;miRanda -0.919994926902061 3.13451641182881e-28 NA NA NA hsa-miR-125a-3p ITGA5 1.24490295132072 5.26925231010328e-06 -2.12715698251452 2.02033561007737e-09 miRanda -0.222041291974005 0.000468461148320253 NA NA NA hsa-miR-148a-3p ITGA5 1.26728238710376 2.52325607402829e-06 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.335119735415635 1.46193695086623e-07 NA NA NA hsa-miR-148b-3p ITGA5 1.97815018171325 6.07715327281595e-26 -2.12715698251452 2.02033561007737e-09 miRNAWalker2_validate -1.0908488713867 2.34079592440706e-42 27328731 Notably transendothelial migration in vitro and extravasation in vivo impaired by singly alternating miR-214 or miR-148b could be overridden by overexpression of ITGA5 or ALCAM in the same tumor cells melanoma hsa-miR-183-5p ITGA5 4.19757025992371 4.79612296318304e-26 -2.12715698251452 2.02033561007737e-09 miRNAWalker2_validate -0.526702139503683 4.90437317422702e-46 NA NA NA hsa-miR-185-3p ITGA5 2.3922478518806 1.3373426768452e-14 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.395940119425658 8.90556512571368e-14 NA NA NA hsa-miR-25-3p ITGA5 1.36472605225697 4.83790725935681e-11 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.776199905439916 7.91324957174219e-23 NA NA NA hsa-miR-26b-5p ITGA5 0.885393662798425 3.2116297961629e-06 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.667665635748541 9.09072166745735e-14 NA NA NA hsa-miR-28-5p ITGA5 0.230152919654905 0.0742909586754846 -2.12715698251452 2.02033561007737e-09 PITA;miRanda -0.372501632838063 0.00788860597768604 NA NA NA hsa-miR-3065-3p ITGA5 2.16221780121195 9.65525739884541e-09 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.284226911268234 2.12109019895557e-10 NA NA NA hsa-miR-30c-5p ITGA5 0.778774633108 0.000285599212429136 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.757351411529925 1.84417569669557e-22 NA NA NA hsa-miR-30d-5p ITGA5 0.675423997639582 0.00270618816039773 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.955254954034185 9.2869963961784e-42 NA NA NA hsa-miR-32-5p ITGA5 2.34056473219422 6.24134585974322e-20 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.640757100774878 3.58505029681858e-25 NA NA NA hsa-miR-326 ITGA5 0.715313016136042 0.0610265683213359 -2.12715698251452 2.02033561007737e-09 PITA;miRanda;miRNATAP -0.146729009238172 0.0014084455695614 NA NA NA hsa-miR-330-5p ITGA5 1.15100069700871 4.85551805046014e-07 -2.12715698251452 2.02033561007737e-09 PITA;miRanda;miRNATAP -0.572930453662933 7.70187343692336e-15 27633518 MicroRNA 330 5p negatively regulates ITGA5 expression in human colorectal cancer; These results suggest that downregulation of miR-330-5p expression may affect CRC development via modulation of ITGA5 expression colorectal cancer hsa-miR-429 ITGA5 4.48815175680773 2.44117492218206e-17 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.424089141025183 3.97269444314843e-52 NA NA NA hsa-miR-484 ITGA5 1.81844463411787 1.82951571230938e-15 -2.12715698251452 2.02033561007737e-09 miRNAWalker2_validate -0.626000197827085 1.90555444898923e-18 NA NA NA hsa-miR-629-3p ITGA5 2.36570947321815 1.33458201201618e-11 -2.12715698251452 2.02033561007737e-09 miRNATAP -0.209114467597752 0.000145240794124226 NA NA NA hsa-miR-92a-3p ITGA5 2.06460102658973 1.44784291084757e-19 -2.12715698251452 2.02033561007737e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.738524384643583 1.80680730352447e-26 23499550 The level of miR-92a expression was significantly inversely correlated with ITGA5 expression in various cancer cells; miR-92a overexpression reduced the luciferase activity of the ITGA5 3'-untranslated region suggesting that ITGA5 mRNA is a direct target of miR-92a ovarian cancer hsa-miR-98-5p ITGA5 1.11154309866014 1.24143909012085e-08 -2.12715698251452 2.02033561007737e-09 miRNAWalker2_validate -0.939941795952251 1.16532317725971e-29 NA NA NA hsa-miR-10b-3p ITGAV 0.77597971642517 0.00264877454133753 -0.0552493406333632 0.795714969238101 MirTarget -0.158358641589343 6.69225270139789e-05 NA NA NA hsa-miR-141-3p ITGAV 5.02396127982626 2.19224509139725e-24 -0.0552493406333632 0.795714969238101 MirTarget -0.125634945314397 7.01655633438231e-11 NA NA NA hsa-miR-16-2-3p ITGAV 2.31623086727196 4.29838149388188e-20 -0.0552493406333632 0.795714969238101 mirMAP -0.199617274846503 2.43792627503413e-07 NA NA NA hsa-miR-186-5p ITGAV 1.47445398888668 3.0781726595413e-15 -0.0552493406333632 0.795714969238101 mirMAP -0.359656849104508 8.23776291207508e-12 NA NA NA hsa-miR-192-5p ITGAV 2.69002528723195 1.22990188194432e-16 -0.0552493406333632 0.795714969238101 miRNAWalker2_validate;MirTarget -0.190974902652764 1.81642812826116e-10 NA NA NA hsa-miR-200a-3p ITGAV 4.59434485520731 6.38952518573476e-18 -0.0552493406333632 0.795714969238101 MirTarget -0.131709203257402 2.633117959538e-13 NA NA NA hsa-miR-25-3p ITGAV 1.36472605225697 4.83790725935681e-11 -0.0552493406333632 0.795714969238101 MirTarget;miRNATAP -0.393852941867199 6.6348888648572e-17 NA NA NA hsa-miR-30e-3p ITGAV -0.215663037684509 0.235375122783546 -0.0552493406333632 0.795714969238101 mirMAP -0.339795441635055 1.84221609877849e-09 NA NA NA hsa-miR-32-5p ITGAV 2.34056473219422 6.24134585974322e-20 -0.0552493406333632 0.795714969238101 miRNAWalker2_validate;MirTarget;miRNATAP -0.21813171757581 9.13747743396107e-09 NA NA NA hsa-miR-328-3p ITGAV 0.596804159297544 0.013858523511843 -0.0552493406333632 0.795714969238101 MirTarget -0.184239805543996 1.34681288230083e-05 NA NA NA hsa-miR-331-5p ITGAV 2.17414714166315 1.54547681391888e-18 -0.0552493406333632 0.795714969238101 PITA -0.200744994858149 8.42791176390003e-07 NA NA NA hsa-miR-33a-3p ITGAV 1.72765312072219 1.51784443453521e-07 -0.0552493406333632 0.795714969238101 MirTarget -0.20605161346585 6.47893191633007e-10 NA NA NA hsa-miR-361-5p ITGAV 0.971859117235239 5.30236555707088e-09 -0.0552493406333632 0.795714969238101 MirTarget;miRanda -0.428107639008486 1.15708286730063e-12 NA NA NA hsa-miR-363-3p ITGAV 1.50575300026701 0.00020976164678918 -0.0552493406333632 0.795714969238101 MirTarget -0.108742654034656 1.39301773890387e-05 NA NA NA hsa-miR-374a-5p ITGAV 0.484615721953736 0.0042981729815149 -0.0552493406333632 0.795714969238101 mirMAP -0.234655511836942 0.000126489523100171 NA NA NA hsa-miR-374b-5p ITGAV 0.0654362503857184 0.722673188879465 -0.0552493406333632 0.795714969238101 mirMAP -0.168523506852159 0.00292302259316201 NA NA NA hsa-miR-429 ITGAV 4.48815175680773 2.44117492218206e-17 -0.0552493406333632 0.795714969238101 miRanda -0.127193818759143 2.65456116358475e-12 NA NA NA hsa-miR-576-5p ITGAV 2.20467023993664 3.4053475193793e-19 -0.0552493406333632 0.795714969238101 PITA;mirMAP -0.196724599850144 7.64027152189049e-07 NA NA NA hsa-miR-582-3p ITGAV 0.00876844181512659 0.977126166214707 -0.0552493406333632 0.795714969238101 MirTarget -0.126654225661071 0.00016778168578043 NA NA NA hsa-miR-589-3p ITGAV 2.51971841868825 2.39125940264107e-11 -0.0552493406333632 0.795714969238101 MirTarget -0.126299636648124 2.84553241173989e-05 NA NA NA hsa-miR-590-3p ITGAV 2.59289455139753 1.03200520972022e-21 -0.0552493406333632 0.795714969238101 MirTarget;PITA;miRanda -0.192092523174197 1.80193428945462e-07 NA NA NA hsa-miR-7-1-3p ITGAV 1.84950311431067 1.25300363397654e-13 -0.0552493406333632 0.795714969238101 mirMAP -0.236895615730496 2.11030326941029e-09 NA NA NA hsa-miR-92a-3p ITGAV 2.06460102658973 1.44784291084757e-19 -0.0552493406333632 0.795714969238101 MirTarget;miRNATAP -0.311573118807097 1.56062452922841e-13 NA NA NA hsa-miR-140-3p ITGB1 0.0608890720479334 0.727716871248724 -0.317990264846452 0.0583538962479715 PITA -0.152968161799928 0.00116014308129053 NA NA NA hsa-miR-16-2-3p ITGB1 2.31623086727196 4.29838149388188e-20 -0.317990264846452 0.0583538962479715 mirMAP -0.141160608447208 3.85032895815224e-06 NA NA NA hsa-miR-183-5p ITGB1 4.19757025992371 4.79612296318304e-26 -0.317990264846452 0.0583538962479715 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.112552819137231 2.29750481257299e-09 NA NA NA hsa-miR-186-5p ITGB1 1.47445398888668 3.0781726595413e-15 -0.317990264846452 0.0583538962479715 miRNAWalker2_validate -0.220899040075317 1.36892502161787e-07 NA NA NA hsa-miR-192-5p ITGB1 2.69002528723195 1.22990188194432e-16 -0.317990264846452 0.0583538962479715 miRNAWalker2_validate -0.126909312363049 9.28728124283711e-08 NA NA NA hsa-miR-25-3p ITGB1 1.36472605225697 4.83790725935681e-11 -0.317990264846452 0.0583538962479715 miRNAWalker2_validate -0.236874100330584 3.73108051799375e-10 NA NA NA hsa-miR-29b-3p ITGB1 1.65828197923813 1.02676780888141e-09 -0.317990264846452 0.0583538962479715 MirTarget;miRNATAP -0.10958332671188 0.00018022560545176 NA NA NA hsa-miR-29c-3p ITGB1 -0.00968972577705429 0.97099586346872 -0.317990264846452 0.0583538962479715 MirTarget;miRNATAP -0.213633384526717 8.03067259735927e-13 26766915 MiR 29c inhibits cell growth invasion and migration of pancreatic cancer by targeting ITGB1; Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c and knockdown of ITGB1 inhibited the proliferation migration and invasion of PC cells which was similar to the effects of overexpression of miR-29c pancreatic cancer hsa-miR-320a ITGB1 0.438165828017084 0.0390159073347133 -0.317990264846452 0.0583538962479715 miRanda -0.184906998403177 1.25967988130064e-06 NA NA NA hsa-miR-320b ITGB1 1.55692969039548 1.41071034251915e-08 -0.317990264846452 0.0583538962479715 miRanda -0.1239407118418 1.87342985560011e-05 NA NA NA hsa-miR-374b-3p ITGB1 0.930487774873495 2.74420094310516e-05 -0.317990264846452 0.0583538962479715 MirTarget -0.133594836312993 0.000254936674249418 NA NA NA hsa-miR-429 ITGB1 4.48815175680773 2.44117492218206e-17 -0.317990264846452 0.0583538962479715 miRanda -0.109929733310157 1.15161131378325e-14 NA NA NA hsa-miR-590-3p ITGB1 2.59289455139753 1.03200520972022e-21 -0.317990264846452 0.0583538962479715 miRanda;mirMAP -0.161045941493014 2.61134487020392e-08 NA NA NA hsa-miR-590-5p ITGB1 3.18300989862077 2.06813568597893e-26 -0.317990264846452 0.0583538962479715 miRanda -0.131829234680063 3.6025921225854e-07 NA NA NA hsa-miR-7-1-3p ITGB1 1.84950311431067 1.25300363397654e-13 -0.317990264846452 0.0583538962479715 MirTarget;mirMAP -0.143757573933581 4.81116164603926e-06 NA NA NA hsa-miR-769-5p ITGB1 1.82023760596845 9.6815886564134e-14 -0.317990264846452 0.0583538962479715 miRNAWalker2_validate -0.178309859576212 2.27127944360586e-08 NA NA NA hsa-let-7a-5p ITGB3 0.618599506841644 2.76973453058748e-05 -2.36514018822678 1.11882034713806e-07 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.989245528826512 1.82973539199889e-11 NA NA NA hsa-let-7b-5p ITGB3 0.604314269683977 0.00140009936153214 -2.36514018822678 1.11882034713806e-07 MirTarget;miRNATAP -0.614334197884385 9.78072145525659e-08 NA NA NA hsa-let-7d-5p ITGB3 1.33236798905207 1.1741085658466e-13 -2.36514018822678 1.11882034713806e-07 MirTarget -0.972385555315623 3.86209598663812e-17 NA NA NA hsa-let-7e-5p ITGB3 0.860104282510173 6.04758298373779e-05 -2.36514018822678 1.11882034713806e-07 MirTarget;miRNATAP -0.438073178533302 1.59192858914311e-05 NA NA NA hsa-let-7f-5p ITGB3 0.495648727272215 0.00355972741198794 -2.36514018822678 1.11882034713806e-07 MirTarget;miRNATAP -0.584915121205566 6.23747436408235e-06 NA NA NA hsa-let-7g-5p ITGB3 1.20061455355116 1.50237505511483e-12 -2.36514018822678 1.11882034713806e-07 MirTarget;miRNATAP -1.17761218427917 2.59918555748576e-22 NA NA NA hsa-miR-185-5p ITGB3 2.34016206907488 1.17481626642022e-26 -2.36514018822678 1.11882034713806e-07 MirTarget -0.69383888203154 3.95451850131206e-14 NA NA NA hsa-miR-186-5p ITGB3 1.47445398888668 3.0781726595413e-15 -2.36514018822678 1.11882034713806e-07 mirMAP -0.877206422678023 2.55789916386277e-15 NA NA NA hsa-miR-18a-3p ITGB3 2.14813400940323 2.23460809936028e-06 -2.36514018822678 1.11882034713806e-07 miRNATAP -0.224657603872067 0.000182579378919658 NA NA NA hsa-miR-1976 ITGB3 2.06550563678192 7.81396978619772e-18 -2.36514018822678 1.11882034713806e-07 MirTarget -0.600731909510262 2.64114704093274e-12 NA NA NA hsa-miR-28-5p ITGB3 0.230152919654905 0.0742909586754846 -2.36514018822678 1.11882034713806e-07 miRanda -0.505515973751828 0.00392489144918646 NA NA NA hsa-miR-30b-5p ITGB3 0.800822374912712 0.000133601914525413 -2.36514018822678 1.11882034713806e-07 mirMAP -0.724774757198107 1.23727568515502e-12 20498642 Enforced constitutive expression of mir-30 in BT-ICs inhibits their self-renewal capacity by reducing Ubc9 and induces apoptosis through silencing ITGB3 breast cancer hsa-miR-30c-5p ITGB3 0.778774633108 0.000285599212429136 -2.36514018822678 1.11882034713806e-07 miRNAWalker2_validate;mirMAP;miRNATAP -0.853248091943228 3.89651966097134e-18 NA NA NA hsa-miR-30d-5p ITGB3 0.675423997639582 0.00270618816039773 -2.36514018822678 1.11882034713806e-07 miRNATAP -0.79173776067464 3.80614379408852e-17 NA NA NA hsa-miR-320a ITGB3 0.438165828017084 0.0390159073347133 -2.36514018822678 1.11882034713806e-07 miRanda -0.795988187522278 2.65520563222487e-15 NA NA NA hsa-miR-320b ITGB3 1.55692969039548 1.41071034251915e-08 -2.36514018822678 1.11882034713806e-07 miRanda -0.644642166125784 1.74012028319029e-17 NA NA NA hsa-miR-3607-3p ITGB3 2.68532138541128 5.66716351955047e-14 -2.36514018822678 1.11882034713806e-07 MirTarget;mirMAP;miRNATAP -0.442398977697993 9.08925492991088e-14 NA NA NA hsa-miR-425-5p ITGB3 3.07071373939774 4.02947460586085e-25 -2.36514018822678 1.11882034713806e-07 MirTarget -0.674667852485928 1.2118842361245e-24 NA NA NA hsa-miR-429 ITGB3 4.48815175680773 2.44117492218206e-17 -2.36514018822678 1.11882034713806e-07 miRanda -0.459266250119302 1.10022358528139e-36 NA NA NA hsa-miR-589-5p ITGB3 1.71990116752371 8.310889042056e-14 -2.36514018822678 1.11882034713806e-07 MirTarget -0.334615923322686 0.000295181496585407 NA NA NA hsa-miR-590-3p ITGB3 2.59289455139753 1.03200520972022e-21 -2.36514018822678 1.11882034713806e-07 PITA;miRanda -0.500125186389998 1.1740515245078e-10 NA NA NA hsa-miR-590-5p ITGB3 3.18300989862077 2.06813568597893e-26 -2.36514018822678 1.11882034713806e-07 miRanda -0.565339284148694 1.14587741951889e-16 NA NA NA hsa-miR-98-5p ITGB3 1.11154309866014 1.24143909012085e-08 -2.36514018822678 1.11882034713806e-07 miRNAWalker2_validate;MirTarget -0.835488358881533 1.08310398420676e-14 26445551 miR 98 targets ITGB3 to inhibit proliferation migration and invasion of non small cell lung cancer; Furthermore we identified that miR-98 exerted inhibitory roles by directly binding to 3'-UTR of ITGB3 mRNA thus negatively regulated the expression of ITGB3; Interestingly upon restoring the expression of ITGB3 the effect of miR-98 on cell proliferation was partially reversed; Our findings suggest that miR-98 prevents proliferation migration and invasion of lung cancer cells by directly binding to the 3'-UTR of ITGB3 mRNA and could be a promising treatment option in anticancer therapy lung squamous cell cancer hsa-miR-335-5p ITGB5 1.77247705492746 2.22457658872091e-06 0.0659632945181734 0.782072361855164 miRNAWalker2_validate -0.116318527732458 0.000119850401605925 NA NA NA hsa-miR-361-5p ITGB5 0.971859117235239 5.30236555707088e-09 0.0659632945181734 0.782072361855164 miRanda -0.370854793541912 5.23628556596546e-08 NA NA NA hsa-miR-378a-5p ITGB5 0.223456081148306 0.386368843153575 0.0659632945181734 0.782072361855164 MirTarget -0.339918050815375 5.45226214614412e-15 NA NA NA hsa-miR-421 ITGB5 1.17791565395543 6.78526676976629e-06 0.0659632945181734 0.782072361855164 miRanda;miRNATAP -0.206863182915145 1.90179639014605e-06 NA NA NA hsa-miR-484 ITGB5 1.81844463411787 1.82951571230938e-15 0.0659632945181734 0.782072361855164 miRNATAP -0.222390468841951 4.59175532460192e-06 NA NA NA hsa-miR-486-5p ITGB5 -0.194913133034028 0.607377798807705 0.0659632945181734 0.782072361855164 miRanda -0.102224900608579 0.000744091379292665 NA NA NA hsa-miR-101-3p JUN 0.522819989585461 0.00375627731618038 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.362533052186516 4.72957409908478e-06 NA NA NA hsa-miR-141-3p JUN 5.02396127982626 2.19224509139725e-24 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.202238939720509 1.9524950223322e-14 NA NA NA hsa-miR-149-5p JUN 2.94200492826326 4.93436498919036e-14 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate;miRNATAP -0.155172431476894 9.83577829040368e-06 NA NA NA hsa-miR-15a-5p JUN 2.34669284378787 1.69544424500258e-23 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.322829003344663 1.37042285263916e-08 NA NA NA hsa-miR-16-5p JUN 1.75824877145857 1.68592440033108e-16 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.384340701644607 1.66878593693069e-09 NA NA NA hsa-miR-200a-3p JUN 4.59434485520731 6.38952518573476e-18 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.185345884656907 9.93412020536435e-14 NA NA NA hsa-miR-200b-3p JUN 3.78235093249346 3.18343003239465e-14 -2.04611084807692 9.1524625995215e-13 MirTarget;TargetScan -0.190113959616059 1.82414115729818e-12 NA NA NA hsa-miR-200c-3p JUN 3.50132673580082 2.42716349086937e-15 -2.04611084807692 9.1524625995215e-13 MirTarget -0.195019704023245 1.57363395803084e-10 NA NA NA hsa-miR-26b-5p JUN 0.885393662798425 3.2116297961629e-06 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.246116506815496 0.00101325681187835 21901137;27078844 When c-Jun N-terminal kinase activity was inhibited using SP600125 expression of miR-26b was induced following γ-irradiation in H1299 cells;MicroRNA 26b inhibits tumor metastasis by targeting the KPNA2/c jun pathway in human gastric cancer ;metastasis lung cancer;gastric cancer hsa-miR-29c-3p JUN -0.00968972577705429 0.97099586346872 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.270579553256343 3.66051574994211e-07 NA NA NA hsa-miR-32-5p JUN 2.34056473219422 6.24134585974322e-20 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.413566434466745 1.10620082409085e-15 NA NA NA hsa-miR-342-3p JUN 1.49115144672245 1.43879249744621e-07 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.133321520548688 0.00731127636739181 NA NA NA hsa-miR-34a-3p JUN 1.75590866103657 8.02801510630657e-09 -2.04611084807692 9.1524625995215e-13 MirTarget -0.279858707540387 3.1061995990995e-08 NA NA NA hsa-miR-429 JUN 4.48815175680773 2.44117492218206e-17 -2.04611084807692 9.1524625995215e-13 MirTarget;PITA;miRanda;miRNATAP -0.188635161083758 5.14832375488061e-14 NA NA NA hsa-miR-455-3p JUN 3.06093594997644 3.54590649799868e-16 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.112839225766699 0.00201102151546805 NA NA NA hsa-miR-501-5p JUN 1.93654809410041 1.3779381780759e-10 -2.04611084807692 9.1524625995215e-13 MirTarget;PITA;miRNATAP -0.24236112135519 2.74349787240435e-07 NA NA NA hsa-miR-542-3p JUN 1.18832665895751 1.98700670691565e-07 -2.04611084807692 9.1524625995215e-13 miRanda -0.2224781000711 0.000312275738377628 NA NA NA hsa-miR-590-3p JUN 2.59289455139753 1.03200520972022e-21 -2.04611084807692 9.1524625995215e-13 miRanda -0.362021445664138 5.65305416742662e-13 NA NA NA hsa-miR-92a-3p JUN 2.06460102658973 1.44784291084757e-19 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.395074792110845 1.74644010636679e-11 NA NA NA hsa-miR-93-5p JUN 3.03961860136032 1.11672209617395e-24 -2.04611084807692 9.1524625995215e-13 miRNAWalker2_validate -0.361575830576226 1.64388759918119e-16 NA NA NA hsa-miR-940 JUN 3.21011374578759 2.7923171128495e-14 -2.04611084807692 9.1524625995215e-13 MirTarget;PITA;miRNATAP -0.231773307807484 3.31037401763421e-11 NA NA NA hsa-miR-590-3p LAMA2 2.59289455139753 1.03200520972022e-21 -2.83761923067566 3.05345389505506e-15 miRanda -0.567223566221854 9.61700716671867e-20 NA NA NA hsa-miR-107 LAMC1 1.30977326593435 1.30372468603965e-11 -0.820359806292778 9.59613230767155e-05 miRanda -0.233579030791372 6.43537798223682e-06 NA NA NA hsa-miR-126-5p LAMC1 0.895338176458417 2.33372756450713e-05 -0.820359806292778 9.59613230767155e-05 mirMAP -0.159911853705003 0.000923609611119757 NA NA NA hsa-miR-140-5p LAMC1 0.844753502512594 3.73722278438606e-05 -0.820359806292778 9.59613230767155e-05 MirTarget;PITA;miRanda;miRNATAP -0.187818567265583 0.000164349930813064 NA NA NA hsa-miR-15a-5p LAMC1 2.34669284378787 1.69544424500258e-23 -0.820359806292778 9.59613230767155e-05 MirTarget -0.279245991959823 5.28867371746872e-12 NA NA NA hsa-miR-15b-5p LAMC1 1.57112623124278 9.14247846750597e-13 -0.820359806292778 9.59613230767155e-05 MirTarget -0.267292362456671 2.53222057416082e-09 NA NA NA hsa-miR-16-5p LAMC1 1.75824877145857 1.68592440033108e-16 -0.820359806292778 9.59613230767155e-05 miRNAWalker2_validate;MirTarget -0.297384176391202 7.25329237041864e-11 NA NA NA hsa-miR-182-5p LAMC1 3.53923166221814 5.07781258121574e-21 -0.820359806292778 9.59613230767155e-05 miRNATAP -0.208617431877303 6.51660327570966e-17 NA NA NA hsa-miR-186-5p LAMC1 1.47445398888668 3.0781726595413e-15 -0.820359806292778 9.59613230767155e-05 mirMAP -0.348967724665269 2.74169617986783e-11 NA NA NA hsa-miR-188-5p LAMC1 2.52825126596644 6.78099435999778e-14 -0.820359806292778 9.59613230767155e-05 MirTarget -0.118785698529413 0.000144532288486678 NA NA NA hsa-miR-200b-3p LAMC1 3.78235093249346 3.18343003239465e-14 -0.820359806292778 9.59613230767155e-05 MirTarget;TargetScan -0.188439272819086 1.35940514922883e-23 NA NA NA hsa-miR-200c-3p LAMC1 3.50132673580082 2.42716349086937e-15 -0.820359806292778 9.59613230767155e-05 MirTarget;miRNATAP -0.189567753679175 8.99034744541273e-19 NA NA NA hsa-miR-29b-3p LAMC1 1.65828197923813 1.02676780888141e-09 -0.820359806292778 9.59613230767155e-05 MirTarget;miRNATAP -0.220232761632421 1.51273199871374e-09 NA NA NA hsa-miR-29c-3p LAMC1 -0.00968972577705429 0.97099586346872 -0.820359806292778 9.59613230767155e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.257554844225706 9.0369958667655e-12 NA NA NA hsa-miR-320a LAMC1 0.438165828017084 0.0390159073347133 -0.820359806292778 9.59613230767155e-05 miRanda -0.143719009142448 0.00309124251798942 NA NA NA hsa-miR-320b LAMC1 1.55692969039548 1.41071034251915e-08 -0.820359806292778 9.59613230767155e-05 miRanda -0.138452288194716 0.000157649490105486 NA NA NA hsa-miR-33a-3p LAMC1 1.72765312072219 1.51784443453521e-07 -0.820359806292778 9.59613230767155e-05 mirMAP -0.152727172481252 5.1457356703767e-06 NA NA NA hsa-miR-361-5p LAMC1 0.971859117235239 5.30236555707088e-09 -0.820359806292778 9.59613230767155e-05 miRanda -0.322314937131198 1.07220917823374e-07 NA NA NA hsa-miR-362-3p LAMC1 2.0756816987665 3.89026064579331e-12 -0.820359806292778 9.59613230767155e-05 miRanda -0.224673273037806 3.01231821033164e-11 NA NA NA hsa-miR-429 LAMC1 4.48815175680773 2.44117492218206e-17 -0.820359806292778 9.59613230767155e-05 MirTarget;PITA;miRanda;miRNATAP -0.172219345654296 1.30033356324259e-22 NA NA NA hsa-miR-590-3p LAMC1 2.59289455139753 1.03200520972022e-21 -0.820359806292778 9.59613230767155e-05 PITA;miRanda;mirMAP -0.231819316952669 1.72376179745425e-10 NA NA NA hsa-miR-7-1-3p LAMC1 1.84950311431067 1.25300363397654e-13 -0.820359806292778 9.59613230767155e-05 mirMAP -0.227585122050958 7.55795416788432e-09 NA NA NA hsa-miR-92a-3p LAMC1 2.06460102658973 1.44784291084757e-19 -0.820359806292778 9.59613230767155e-05 miRNAWalker2_validate -0.25585756980471 1.61550207656933e-09 NA NA NA hsa-miR-942-5p LAMC1 2.35195531153712 5.45059325728841e-16 -0.820359806292778 9.59613230767155e-05 MirTarget -0.199082047259579 2.90254597627543e-09 NA NA NA hsa-miR-96-5p LAMC1 4.89433085814374 1.92000659886961e-31 -0.820359806292778 9.59613230767155e-05 MirTarget;TargetScan;miRNATAP -0.194526518099266 2.67470382634379e-18 NA NA NA hsa-miR-98-5p LAMC1 1.11154309866014 1.24143909012085e-08 -0.820359806292778 9.59613230767155e-05 miRNAWalker2_validate -0.287258937188904 2.27097321682406e-08 NA NA NA hsa-miR-125a-5p LAMC2 0.599529391575274 0.0102300147180307 2.24370532975042 5.48773878317138e-05 MirTarget;miRanda -0.301052127742519 0.00995434131377062 NA NA NA hsa-miR-107 LOX 1.30977326593435 1.30372468603965e-11 -0.0884445896516479 0.832402358891942 miRanda -0.610721463167841 1.56835965581518e-09 NA NA NA hsa-miR-149-5p LOX 2.94200492826326 4.93436498919036e-14 -0.0884445896516479 0.832402358891942 miRNATAP -0.249558115824984 4.77695400595021e-07 NA NA NA hsa-miR-15b-3p LOX 2.33847028227712 4.29662877950836e-19 -0.0884445896516479 0.832402358891942 mirMAP -0.303793675048094 3.68447141540662e-05 NA NA NA hsa-miR-181c-5p LOX 1.58587920618301 1.57506918816933e-10 -0.0884445896516479 0.832402358891942 miRNATAP -0.393034803418783 7.13265983704074e-07 NA NA NA hsa-miR-186-5p LOX 1.47445398888668 3.0781726595413e-15 -0.0884445896516479 0.832402358891942 mirMAP -0.57651544622219 3.13888646691798e-08 NA NA NA hsa-miR-200b-3p LOX 3.78235093249346 3.18343003239465e-14 -0.0884445896516479 0.832402358891942 TargetScan -0.435178794768354 2.86721238616097e-33 NA NA NA hsa-miR-26b-5p LOX 0.885393662798425 3.2116297961629e-06 -0.0884445896516479 0.832402358891942 mirMAP -0.517158171851477 8.97377959769039e-07 NA NA NA hsa-miR-29b-3p LOX 1.65828197923813 1.02676780888141e-09 -0.0884445896516479 0.832402358891942 miRNATAP -0.36378329043701 4.96951569500478e-07 NA NA NA hsa-miR-29c-3p LOX -0.00968972577705429 0.97099586346872 -0.0884445896516479 0.832402358891942 miRNATAP -0.727022188682061 7.06313894359967e-24 NA NA NA hsa-miR-3065-3p LOX 2.16221780121195 9.65525739884541e-09 -0.0884445896516479 0.832402358891942 miRNATAP -0.141620925812618 0.0071356812331241 NA NA NA hsa-miR-30c-5p LOX 0.778774633108 0.000285599212429136 -0.0884445896516479 0.832402358891942 miRNATAP -0.826876461506899 4.79852155566846e-20 NA NA NA hsa-miR-30d-5p LOX 0.675423997639582 0.00270618816039773 -0.0884445896516479 0.832402358891942 miRNATAP -0.952820498763882 6.97580726658835e-30 NA NA NA hsa-miR-32-3p LOX 2.02436999565685 5.94091197945307e-09 -0.0884445896516479 0.832402358891942 mirMAP -0.374079222072612 5.32854101188529e-09 NA NA NA hsa-miR-335-3p LOX 3.08791651139852 5.31309869723517e-12 -0.0884445896516479 0.832402358891942 mirMAP -0.161567148636791 0.000219600113614662 NA NA NA hsa-miR-335-5p LOX 1.77247705492746 2.22457658872091e-06 -0.0884445896516479 0.832402358891942 miRNAWalker2_validate -0.191343528104139 0.00031509211717277 NA NA NA hsa-miR-361-5p LOX 0.971859117235239 5.30236555707088e-09 -0.0884445896516479 0.832402358891942 miRanda;mirMAP -0.797316121848868 1.67990612929834e-11 NA NA NA hsa-miR-374a-5p LOX 0.484615721953736 0.0042981729815149 -0.0884445896516479 0.832402358891942 mirMAP -0.37523372125307 0.00183236204692887 NA NA NA hsa-miR-429 LOX 4.48815175680773 2.44117492218206e-17 -0.0884445896516479 0.832402358891942 miRanda;miRNATAP -0.386564774555497 7.77605610448384e-30 NA NA NA hsa-miR-508-3p LOX 1.05493034310846 0.0393857095042515 -0.0884445896516479 0.832402358891942 mirMAP -0.105178246692873 0.00893330484405301 NA NA NA hsa-miR-590-3p LOX 2.59289455139753 1.03200520972022e-21 -0.0884445896516479 0.832402358891942 miRanda;mirMAP -0.243355496476731 0.000840210551719917 NA NA NA hsa-miR-664a-3p LOX 0.634721925861133 0.00520070178640421 -0.0884445896516479 0.832402358891942 mirMAP -0.741942990855353 5.46502495851549e-18 NA NA NA hsa-miR-944 LOX 2.91186649218281 1.31574753528144e-06 -0.0884445896516479 0.832402358891942 mirMAP;miRNATAP -0.201384843082866 2.0535013091819e-09 NA NA NA hsa-miR-132-3p LOXL1 0.156276992635384 0.408190812100704 -0.20099517849352 0.572149069168718 miRNAWalker2_validate -0.389306838646231 2.16647942619125e-05 NA NA NA hsa-miR-146b-3p LOXL1 1.10569195233795 0.000660632782194023 -0.20099517849352 0.572149069168718 miRNATAP -0.234026003520591 7.81317391354402e-06 NA NA NA hsa-miR-148b-3p LOXL1 1.97815018171325 6.07715327281595e-26 -0.20099517849352 0.572149069168718 miRNAWalker2_validate -0.415926690575965 1.38943209158666e-06 NA NA NA hsa-miR-193b-3p LOXL1 2.25711804611899 4.1940744806631e-14 -0.20099517849352 0.572149069168718 miRNAWalker2_validate -0.205060163597471 0.000230170284679554 NA NA NA hsa-miR-3065-5p LOXL1 2.74629919868982 1.86846589298284e-08 -0.20099517849352 0.572149069168718 MirTarget -0.161840100031453 0.00012697625550053 NA NA NA hsa-miR-93-5p LOXL1 3.03961860136032 1.11672209617395e-24 -0.20099517849352 0.572149069168718 miRNAWalker2_validate -0.245159976547155 6.54690327401235e-06 NA NA NA hsa-miR-192-5p LOXL2 2.69002528723195 1.22990188194432e-16 0.752274659894764 0.0169514910560244 miRNAWalker2_validate -0.180348106199117 6.27015330629637e-05 NA NA NA hsa-miR-28-5p LOXL2 0.230152919654905 0.0742909586754846 0.752274659894764 0.0169514910560244 miRanda -0.455973906650758 0.000181459548210797 NA NA NA hsa-miR-361-5p LOXL2 0.971859117235239 5.30236555707088e-09 0.752274659894764 0.0169514910560244 miRanda -0.53628682071833 2.61457157430625e-09 NA NA NA hsa-miR-107 LRP1 1.30977326593435 1.30372468603965e-11 -1.26236196538325 9.18371957503118e-07 PITA;miRNATAP -0.600829796389875 5.916468078658e-23 NA NA NA hsa-miR-126-5p LRP1 0.895338176458417 2.33372756450713e-05 -1.26236196538325 9.18371957503118e-07 MirTarget -0.28847607605435 9.78791314151731e-07 NA NA NA hsa-miR-185-3p LRP1 2.3922478518806 1.3373426768452e-14 -1.26236196538325 9.18371957503118e-07 MirTarget -0.287783390215415 4.79523192424546e-14 NA NA NA hsa-miR-200b-3p LRP1 3.78235093249346 3.18343003239465e-14 -1.26236196538325 9.18371957503118e-07 TargetScan -0.234923359188771 2.85510155543237e-24 NA NA NA hsa-miR-205-5p LRP1 4.1389800495524 2.05488295686453e-12 -1.26236196538325 9.18371957503118e-07 miRNAWalker2_validate;miRTarBase;MirTarget -0.115577948655869 1.63832036844632e-08 24525843 miR 205 down regulation promotes proliferation of dermatofibrosarcoma protuberans tumor cells by regulating LRP 1 and ERK phosphorylation; In situ hybridization showed that miR-205 expression was evident in dermal fibroblasts of normal skin although hardly detected in tumor cells of DF or DFSP miR-205 inhibitor increased cell proliferation and the luciferase activity of 3'UTR of low-density lipoprotein receptor-related protein-1 LRP-1 in cultured normal dermal fibroblasts; Taken together LRP-1 overexpression caused by the miR-205 down-regulation may play a role in the abnormal proliferation of DFSP cells via directly regulating ERK phosphorylation sarcoma hsa-miR-324-5p LRP1 2.95683728155095 1.32960514360912e-20 -1.26236196538325 9.18371957503118e-07 miRanda -0.338598537338024 6.2760798247049e-21 NA NA NA hsa-miR-335-5p LRP1 1.77247705492746 2.22457658872091e-06 -1.26236196538325 9.18371957503118e-07 miRNAWalker2_validate -0.173140816839671 1.34143845500037e-07 NA NA NA hsa-miR-339-5p LRP1 2.68710938429893 3.03134080808154e-16 -1.26236196538325 9.18371957503118e-07 miRanda -0.239419810247737 3.56359885655537e-11 NA NA NA hsa-miR-342-3p LRP1 1.49115144672245 1.43879249744621e-07 -1.26236196538325 9.18371957503118e-07 miRanda -0.130760227366354 0.00287922506088445 NA NA NA hsa-miR-429 LRP1 4.48815175680773 2.44117492218206e-17 -1.26236196538325 9.18371957503118e-07 PITA;miRanda;miRNATAP -0.222979078272635 3.42028894464172e-25 NA NA NA hsa-miR-590-3p LRP1 2.59289455139753 1.03200520972022e-21 -1.26236196538325 9.18371957503118e-07 PITA;miRanda;miRNATAP -0.387578548986507 7.30876115673148e-19 NA NA NA hsa-miR-590-5p LRP1 3.18300989862077 2.06813568597893e-26 -1.26236196538325 9.18371957503118e-07 miRanda -0.368041203338874 2.12076840439303e-21 NA NA NA hsa-miR-944 LRP1 2.91186649218281 1.31574753528144e-06 -1.26236196538325 9.18371957503118e-07 MirTarget;PITA -0.113120385212946 7.59986065627279e-08 NA NA NA hsa-miR-107 LRRC15 1.30977326593435 1.30372468603965e-11 1.20484684767548 0.110887343305062 PITA -1.21114012482915 3.17576661756128e-11 NA NA NA hsa-miR-15b-3p LRRC15 2.33847028227712 4.29662877950836e-19 1.20484684767548 0.110887343305062 mirMAP -0.845520159360367 1.27164710078479e-10 NA NA NA hsa-miR-17-3p LRRC15 2.2704817679209 1.1667437320211e-22 1.20484684767548 0.110887343305062 mirMAP -0.752930562673503 4.26220502680351e-07 NA NA NA hsa-miR-181c-3p LRRC15 2.12243544912484 2.25156887166019e-14 1.20484684767548 0.110887343305062 mirMAP -0.541901435074129 1.98688712404063e-05 NA NA NA hsa-miR-185-5p LRRC15 2.34016206907488 1.17481626642022e-26 1.20484684767548 0.110887343305062 miRNATAP -0.540876396594014 0.000590287354558502 NA NA NA hsa-miR-200a-3p LRRC15 4.59434485520731 6.38952518573476e-18 1.20484684767548 0.110887343305062 mirMAP -0.478879524183893 6.67716411563626e-14 NA NA NA hsa-miR-2110 LRRC15 1.16625590651194 6.4784195289885e-05 1.20484684767548 0.110887343305062 mirMAP -0.771390218274243 5.01522002874866e-09 NA NA NA hsa-miR-30b-5p LRRC15 0.800822374912712 0.000133601914525413 1.20484684767548 0.110887343305062 mirMAP -0.978897625978744 1.34709113954604e-08 NA NA NA hsa-miR-30c-5p LRRC15 0.778774633108 0.000285599212429136 1.20484684767548 0.110887343305062 mirMAP -1.13891844776575 9.02812085803578e-12 NA NA NA hsa-miR-30d-5p LRRC15 0.675423997639582 0.00270618816039773 1.20484684767548 0.110887343305062 mirMAP -1.50852395212696 2.17908766702606e-22 NA NA NA hsa-miR-30e-5p LRRC15 1.23904909539663 1.35561917122157e-09 1.20484684767548 0.110887343305062 mirMAP -1.5632603643374 2.57357969597595e-20 NA NA NA hsa-miR-331-3p LRRC15 2.28379581858927 1.99663919173155e-18 1.20484684767548 0.110887343305062 mirMAP -1.02244929160644 5.34780374410892e-15 NA NA NA hsa-miR-425-5p LRRC15 3.07071373939774 4.02947460586085e-25 1.20484684767548 0.110887343305062 mirMAP -0.595984155646793 2.23188694699919e-07 NA NA NA hsa-miR-429 LRRC15 4.48815175680773 2.44117492218206e-17 1.20484684767548 0.110887343305062 miRNATAP -0.451136889445358 2.91243727122436e-12 NA NA NA hsa-miR-590-3p LRRC15 2.59289455139753 1.03200520972022e-21 1.20484684767548 0.110887343305062 miRanda;mirMAP -0.400075339383911 0.00247264966960991 NA NA NA hsa-miR-125a-5p LUM 0.599529391575274 0.0102300147180307 -1.6117306534845 0.000480193345086782 miRanda -0.275408459944122 0.00436020669254113 NA NA NA hsa-miR-129-5p LUM -0.524170159980738 0.222582956006346 -1.6117306534845 0.000480193345086782 miRanda -0.282685327783989 7.89033682235448e-08 NA NA NA hsa-miR-16-2-3p LUM 2.31623086727196 4.29838149388188e-20 -1.6117306534845 0.000480193345086782 mirMAP -0.660213818963125 1.27430461356769e-15 NA NA NA hsa-miR-590-3p LUM 2.59289455139753 1.03200520972022e-21 -1.6117306534845 0.000480193345086782 miRanda;mirMAP -0.527367639736064 3.33807802422622e-11 NA NA NA hsa-miR-590-5p LUM 3.18300989862077 2.06813568597893e-26 -1.6117306534845 0.000480193345086782 MirTarget;PITA;miRanda -0.507633490483138 6.8552538662316e-13 NA NA NA hsa-miR-7-1-3p LUM 1.84950311431067 1.25300363397654e-13 -1.6117306534845 0.000480193345086782 mirMAP -0.583003021950221 1.07708207253126e-11 NA NA NA hsa-miR-944 LUM 2.91186649218281 1.31574753528144e-06 -1.6117306534845 0.000480193345086782 mirMAP -0.217331610152689 6.38277332645746e-09 NA NA NA hsa-miR-330-3p MAGEE1 0.876747334239085 0.00073709016089703 -0.810493365602985 0.0131022798867108 miRNATAP -0.212202574907804 0.00047847989272494 NA NA NA hsa-miR-671-5p MAGEE1 2.97733652243246 1.21148452344738e-23 -0.810493365602985 0.0131022798867108 MirTarget -0.165036269330169 0.00197533917502943 NA NA NA hsa-miR-21-5p MATN2 2.73773305747971 1.38864982139576e-43 -3.20506398822082 1.04689885829435e-12 miRNATAP -0.613383477518015 1.20649424074365e-09 NA NA NA hsa-miR-335-3p MATN2 3.08791651139852 5.31309869723517e-12 -3.20506398822082 1.04689885829435e-12 mirMAP -0.126927307219918 0.00912528456088104 NA NA NA hsa-miR-590-3p MATN2 2.59289455139753 1.03200520972022e-21 -3.20506398822082 1.04689885829435e-12 miRanda;mirMAP;miRNATAP -0.394399845333776 8.75187282326446e-07 NA NA NA hsa-miR-590-5p MATN2 3.18300989862077 2.06813568597893e-26 -3.20506398822082 1.04689885829435e-12 PITA;miRanda;miRNATAP -0.344754498029713 1.48667671356799e-06 NA NA NA hsa-miR-429 MATN3 4.48815175680773 2.44117492218206e-17 1.99731738140871 4.21676914032574e-08 miRanda -0.101119485543692 0.0017882032851742 NA NA NA hsa-miR-10b-3p MFAP5 0.77597971642517 0.00264877454133753 -4.35255383201982 2.63926165947326e-07 MirTarget -1.41552936435435 3.57580594824384e-20 NA NA NA hsa-miR-126-5p MFAP5 0.895338176458417 2.33372756450713e-05 -4.35255383201982 2.63926165947326e-07 mirMAP -1.07912219595614 2.41366098143129e-08 NA NA NA hsa-miR-15a-5p MFAP5 2.34669284378787 1.69544424500258e-23 -4.35255383201982 2.63926165947326e-07 MirTarget -1.55589424413818 2.0241340774571e-22 NA NA NA hsa-miR-15b-3p MFAP5 2.33847028227712 4.29662877950836e-19 -4.35255383201982 2.63926165947326e-07 MirTarget -1.40715801761237 2.33701897327065e-22 NA NA NA hsa-miR-15b-5p MFAP5 1.57112623124278 9.14247846750597e-13 -4.35255383201982 2.63926165947326e-07 MirTarget -1.82682743924369 1.00823808694788e-25 NA NA NA hsa-miR-16-5p MFAP5 1.75824877145857 1.68592440033108e-16 -4.35255383201982 2.63926165947326e-07 MirTarget -1.78745112531755 1.8251207573572e-23 NA NA NA hsa-miR-200b-3p MFAP5 3.78235093249346 3.18343003239465e-14 -4.35255383201982 2.63926165947326e-07 TargetScan -0.828024088871185 5.0556047717331e-28 NA NA NA hsa-miR-200c-3p MFAP5 3.50132673580082 2.42716349086937e-15 -4.35255383201982 2.63926165947326e-07 miRNATAP -0.904430228024108 2.48772724952338e-26 NA NA NA hsa-miR-32-3p MFAP5 2.02436999565685 5.94091197945307e-09 -4.35255383201982 2.63926165947326e-07 mirMAP -1.07536558144208 7.98364012598697e-17 NA NA NA hsa-miR-320a MFAP5 0.438165828017084 0.0390159073347133 -4.35255383201982 2.63926165947326e-07 miRanda -1.43338637040127 7.35428957194363e-14 NA NA NA hsa-miR-320b MFAP5 1.55692969039548 1.41071034251915e-08 -4.35255383201982 2.63926165947326e-07 miRanda -1.04335966481873 7.07998268068881e-13 NA NA NA hsa-miR-33a-3p MFAP5 1.72765312072219 1.51784443453521e-07 -4.35255383201982 2.63926165947326e-07 MirTarget -1.25058561031349 8.38534016913054e-22 NA NA NA hsa-miR-361-5p MFAP5 0.971859117235239 5.30236555707088e-09 -4.35255383201982 2.63926165947326e-07 miRanda -2.09385614084161 2.00201304351555e-18 NA NA NA hsa-miR-374a-5p MFAP5 0.484615721953736 0.0042981729815149 -4.35255383201982 2.63926165947326e-07 mirMAP -0.652842642338357 0.00846183876591922 NA NA NA hsa-miR-429 MFAP5 4.48815175680773 2.44117492218206e-17 -4.35255383201982 2.63926165947326e-07 miRanda;miRNATAP -0.762359981181017 3.00075745420348e-27 NA NA NA hsa-miR-590-3p MFAP5 2.59289455139753 1.03200520972022e-21 -4.35255383201982 2.63926165947326e-07 miRanda;mirMAP -0.974824684043887 3.27543563578167e-11 NA NA NA hsa-miR-125a-3p MGP 1.24490295132072 5.26925231010328e-06 -2.75144017007921 1.4729852831326e-08 miRanda -0.356277437855236 3.80574042372251e-05 NA NA NA hsa-miR-26b-5p MGP 0.885393662798425 3.2116297961629e-06 -2.75144017007921 1.4729852831326e-08 miRNAWalker2_validate -0.940800600383174 1.33470723246516e-14 NA NA NA hsa-miR-335-5p MGP 1.77247705492746 2.22457658872091e-06 -2.75144017007921 1.4729852831326e-08 miRNAWalker2_validate -0.219718080310667 0.000481049488813114 NA NA NA hsa-miR-944 MGP 2.91186649218281 1.31574753528144e-06 -2.75144017007921 1.4729852831326e-08 MirTarget -0.486887154923014 4.88829293563556e-40 NA NA NA hsa-miR-29b-2-5p MMP14 0.910668640983475 0.00666655585493488 0.802421218833274 0.000623273796718247 mirMAP -0.232238745809812 2.33667999510222e-12 NA NA NA hsa-miR-331-3p MMP14 2.28379581858927 1.99663919173155e-18 0.802421218833274 0.000623273796718247 mirMAP -0.166806736651855 6.68397776734372e-05 NA NA NA hsa-miR-374a-5p MMP14 0.484615721953736 0.0042981729815149 0.802421218833274 0.000623273796718247 MirTarget -0.179495634533932 0.00837312430525228 NA NA NA hsa-miR-484 MMP14 1.81844463411787 1.82951571230938e-15 0.802421218833274 0.000623273796718247 PITA;miRNATAP -0.16460594555815 0.000658493275065228 NA NA NA hsa-miR-532-3p MMP14 1.96631878320218 4.53421954361695e-13 0.802421218833274 0.000623273796718247 miRNATAP -0.178604400095257 1.09848420594437e-05 NA NA NA hsa-miR-17-5p MMP2 3.2710598467455 9.93128340539455e-27 -1.52635503513524 0.000190422340278307 miRNAWalker2_validate;TargetScan -0.611859212720341 2.45147560131697e-26 NA NA NA hsa-miR-2110 MMP2 1.16625590651194 6.4784195289885e-05 -1.52635503513524 0.000190422340278307 miRNATAP -0.530732286114285 7.4652155294573e-14 NA NA NA hsa-miR-29b-3p MMP2 1.65828197923813 1.02676780888141e-09 -1.52635503513524 0.000190422340278307 miRNAWalker2_validate;miRTarBase;miRNATAP -0.250887914489997 0.00048896651315263 26155940;20657750;25866219;24130681;24130168;26063204 In this study we found that only miR-29b inhibited tumor cell migration and invasion by reducing MMP-2 activity via phospho-AKT/β-catenin signaling and stimulated a more epithelial-like morphology;Further a novel target with potential implications for invasion and metastasis matrix metallopeptidase-2 MMP-2 was identified and confirmed to be a miR-29b target in prostate cancer cells;miR 29b inhibits the progression of esophageal squamous cell carcinoma by targeting MMP 2; The impact of overexpression of miR-29b on putative target MMP-2 were subsequently confirmed via Western blot; Overexpression of miR-29b significantly decreased p<0.05 the protein level of MMP-2 which has previously been identified as a direct target of miR-29b; Thus our study demonstrated that overexpression of miR-29b inhibits tumor growth in part by targeting MMP-2;Since miR-29b plays a role in regulating the migration of cancer cells we hypothesized that HAG induces miR-29b expression to target matrix metalloproteinase-2 MMP-2 thereby suppressing the migration of colon cancer cells; Our study supports the understanding that targeting MMP-2 by miR-29b is a mechanism by which HAG suppresses the migration of colon cancer cells;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC;Furthermore the dual-luciferase reporter assay demonstrated that miR-29b inhibited the expression of the luciferase gene containing the 3'-UTRs of MMP2 and PTEN mRNA; Western blotting and quantitative RT-PCR indicated that miR-29b down-regulated the expression of MMP2 at the protein and mRNA levels; Taken together our results demonstrate that miR-29b serves as a tumor metastasis suppressor which suppresses NSCLC cell metastasis by directly inhibiting MMP2 expression cell migration;metastasis;progression;;;metastasis glioblastoma;prostate cancer;esophageal cancer;colon cancer;gastric cancer;lung squamous cell cancer hsa-miR-29c-3p MMP2 -0.00968972577705429 0.97099586346872 -1.52635503513524 0.000190422340278307 miRNATAP -0.260299007452096 0.000518470167057677 23936390;25863127 Furthermore the dual-luciferase reporter assay demonstrated that miR-29c inhibited the expression of the luciferase gene containing the 3'-UTRs of integrin β1 and MMP2 mRNA; Western blotting indicated that miR-29c downregulated the expression of integrin β1 and MMP2 at the protein level; Gelatin zymography analysis further confirmed that miR-29c decreased MMP2 enzyme activity;miR-29c suppresses cell migration and invasion by targeting the MMP2 3'UTR; miR-29c plays an important role in mediating pancreatic cancer metastasis to the liver by targeting MMP2 ;cell migration;metastasis lung cancer;pancreatic cancer hsa-miR-3065-3p MMP2 2.16221780121195 9.65525739884541e-09 -1.52635503513524 0.000190422340278307 miRNATAP -0.220668078820587 1.90152200523374e-05 NA NA NA hsa-miR-330-3p MMP2 0.876747334239085 0.00073709016089703 -1.52635503513524 0.000190422340278307 miRNATAP -0.456503265038085 1.38069558259724e-09 NA NA NA hsa-miR-335-5p MMP2 1.77247705492746 2.22457658872091e-06 -1.52635503513524 0.000190422340278307 miRNAWalker2_validate -0.202260798253999 0.000111719457854766 NA NA NA hsa-miR-421 MMP2 1.17791565395543 6.78526676976629e-06 -1.52635503513524 0.000190422340278307 miRanda -0.572854630381992 6.67602604790993e-15 NA NA NA hsa-miR-451a MMP2 0.239052705432028 0.545761031256574 -1.52635503513524 0.000190422340278307 miRNAWalker2_validate;miRTarBase -0.144347529278139 0.0041653856998698 27173190 Furthermore miR-451 overexpression reduced MMP-2 protein expression levels; In addition neutralization of miR-451 by anti-miR-451 antibody reversed the effect of propofol on cell proliferation and apoptosis and upregulated MMP-2 expression in the SGC-7901 cells; Propofol effectively inhibited proliferation and induced apoptosis in gastric cancer cells which was partly owing to the downregulation of MMP-2 expression by miR-451 gastric cancer hsa-miR-106a-5p MMP3 2.48882002962836 1.99757727374521e-12 -0.531092454582771 0.500895901120092 MirTarget -0.52002622735815 5.56362659155627e-07 NA NA NA hsa-miR-106b-5p MMP3 2.46782146831112 1.36171495805632e-23 -0.531092454582771 0.500895901120092 MirTarget -0.973379647130741 1.27070112270456e-11 NA NA NA hsa-miR-17-5p MMP3 3.2710598467455 9.93128340539455e-27 -0.531092454582771 0.500895901120092 MirTarget -0.523671386113051 6.79471910524395e-06 NA NA NA hsa-miR-20a-5p MMP3 3.15577933619191 4.19753346442454e-25 -0.531092454582771 0.500895901120092 MirTarget -0.572124812618394 9.84463468450513e-07 NA NA NA hsa-miR-20b-5p MMP3 2.07706563022469 1.10107236083433e-05 -0.531092454582771 0.500895901120092 MirTarget -0.431134512741991 4.43313712450041e-08 NA NA NA hsa-miR-590-5p MMP3 3.18300989862077 2.06813568597893e-26 -0.531092454582771 0.500895901120092 miRanda -0.464461943039239 0.000152747056351865 NA NA NA hsa-miR-93-5p MMP3 3.03961860136032 1.11672209617395e-24 -0.531092454582771 0.500895901120092 MirTarget -0.789394798271743 3.29922128853699e-11 NA NA NA hsa-miR-188-5p MSX1 2.52825126596644 6.78099435999778e-14 -1.98614998021276 1.06313554606633e-08 PITA;miRNATAP -0.176290382888596 0.000748607706036539 NA NA NA hsa-miR-21-5p MSX1 2.73773305747971 1.38864982139576e-43 -1.98614998021276 1.06313554606633e-08 miRNATAP -0.327290525395078 2.66052245098633e-05 NA NA NA hsa-miR-590-3p MSX1 2.59289455139753 1.03200520972022e-21 -1.98614998021276 1.06313554606633e-08 miRanda -0.294536449476524 1.53114304609964e-06 NA NA NA hsa-miR-590-5p MSX1 3.18300989862077 2.06813568597893e-26 -1.98614998021276 1.06313554606633e-08 miRanda;miRNATAP -0.289080564002 1.15060083892418e-07 NA NA NA hsa-miR-101-3p MXRA5 0.522819989585461 0.00375627731618038 -0.811220204803127 0.0619192963015959 miRNATAP -0.468558934052313 6.46692852611157e-05 NA NA NA hsa-miR-144-3p MXRA5 0.658119849508907 0.146943823997989 -0.811220204803127 0.0619192963015959 MirTarget;miRNATAP -0.200770147450215 2.40447410912586e-05 NA NA NA hsa-miR-185-5p MXRA5 2.34016206907488 1.17481626642022e-26 -0.811220204803127 0.0619192963015959 MirTarget -0.444539822340059 7.52542079531609e-07 NA NA NA hsa-miR-30d-5p MXRA5 0.675423997639582 0.00270618816039773 -0.811220204803127 0.0619192963015959 miRNATAP -0.564942542670147 8.66050766387756e-10 NA NA NA hsa-miR-590-3p MXRA5 2.59289455139753 1.03200520972022e-21 -0.811220204803127 0.0619192963015959 MirTarget;PITA;miRanda -0.339961294945237 6.74920619366603e-06 NA NA NA hsa-miR-330-5p MYL9 1.15100069700871 4.85551805046014e-07 -3.65545077183042 1.329070048905e-16 MirTarget;miRanda -0.803941007104577 4.63300493768201e-18 NA NA NA hsa-miR-491-5p MYL9 0.615770352820862 0.0418295628761654 -3.65545077183042 1.329070048905e-16 MirTarget;miRanda;miRNATAP -0.464887421811928 2.06987910593985e-09 NA NA NA hsa-let-7a-3p MYLK 1.42015538786275 7.03375209382654e-13 -3.91755634527497 1.71047666943349e-18 mirMAP -0.917097657239513 1.82836514801439e-17 NA NA NA hsa-let-7b-3p MYLK 0.868207752019623 1.30460056774366e-05 -3.91755634527497 1.71047666943349e-18 mirMAP -0.636094574237506 1.25186577321218e-08 NA NA NA hsa-let-7f-1-3p MYLK 1.55054488387679 7.31326775537952e-11 -3.91755634527497 1.71047666943349e-18 mirMAP -0.432595338085735 5.43016203197889e-06 NA NA NA hsa-miR-107 MYLK 1.30977326593435 1.30372468603965e-11 -3.91755634527497 1.71047666943349e-18 miRanda -1.18584646924972 3.14478100232715e-28 NA NA NA hsa-miR-126-5p MYLK 0.895338176458417 2.33372756450713e-05 -3.91755634527497 1.71047666943349e-18 mirMAP -0.642405012380797 8.53271744660032e-10 NA NA NA hsa-miR-129-5p MYLK -0.524170159980738 0.222582956006346 -3.91755634527497 1.71047666943349e-18 miRanda;mirMAP -0.177822677863062 0.000872764838815631 NA NA NA hsa-miR-142-3p MYLK 2.75247908790621 1.45636065474764e-12 -3.91755634527497 1.71047666943349e-18 PITA;miRanda -0.152936432315784 0.00671623618881023 NA NA NA hsa-miR-15a-5p MYLK 2.34669284378787 1.69544424500258e-23 -3.91755634527497 1.71047666943349e-18 MirTarget;miRNATAP -1.1376014500781 1.66386279239224e-43 NA NA NA hsa-miR-15b-5p MYLK 1.57112623124278 9.14247846750597e-13 -3.91755634527497 1.71047666943349e-18 MirTarget;miRNATAP -1.22071426180065 5.67720661684284e-41 NA NA NA hsa-miR-16-2-3p MYLK 2.31623086727196 4.29838149388188e-20 -3.91755634527497 1.71047666943349e-18 mirMAP -1.01891133752891 6.11806700989552e-39 NA NA NA hsa-miR-16-5p MYLK 1.75824877145857 1.68592440033108e-16 -3.91755634527497 1.71047666943349e-18 MirTarget;miRNATAP -1.27368050484122 4.34861154417043e-43 NA NA NA hsa-miR-186-5p MYLK 1.47445398888668 3.0781726595413e-15 -3.91755634527497 1.71047666943349e-18 mirMAP -1.30642543356465 4.95599792323635e-33 NA NA NA hsa-miR-193b-3p MYLK 2.25711804611899 4.1940744806631e-14 -3.91755634527497 1.71047666943349e-18 miRNAWalker2_validate -0.391979780548656 6.12171605435737e-08 NA NA NA hsa-miR-200b-3p MYLK 3.78235093249346 3.18343003239465e-14 -3.91755634527497 1.71047666943349e-18 TargetScan -0.526329964483609 5.5802062510382e-40 NA NA NA hsa-miR-32-3p MYLK 2.02436999565685 5.94091197945307e-09 -3.91755634527497 1.71047666943349e-18 mirMAP -0.662423975868502 1.13862201526482e-21 NA NA NA hsa-miR-320a MYLK 0.438165828017084 0.0390159073347133 -3.91755634527497 1.71047666943349e-18 miRanda -0.919702242269842 3.337003248828e-19 NA NA NA hsa-miR-320b MYLK 1.55692969039548 1.41071034251915e-08 -3.91755634527497 1.71047666943349e-18 miRanda -0.848411878476523 3.88394315619199e-29 NA NA NA hsa-miR-335-3p MYLK 3.08791651139852 5.31309869723517e-12 -3.91755634527497 1.71047666943349e-18 mirMAP -0.377249346771184 1.86556605665484e-15 NA NA NA hsa-miR-33a-3p MYLK 1.72765312072219 1.51784443453521e-07 -3.91755634527497 1.71047666943349e-18 mirMAP -0.704731761953124 1.63150834706062e-23 NA NA NA hsa-miR-34c-5p MYLK 2.07190852984647 7.35776320806257e-08 -3.91755634527497 1.71047666943349e-18 miRanda -0.243927352791597 6.91717478100386e-05 NA NA NA hsa-miR-362-5p MYLK 1.59303749908759 9.582675908797e-08 -3.91755634527497 1.71047666943349e-18 TargetScan;miRNATAP -0.389712204855666 1.23329011603095e-07 NA NA NA hsa-miR-3653-3p MYLK 1.85886928622326 2.98407490336841e-08 -3.91755634527497 1.71047666943349e-18 MirTarget -0.609824101779484 1.05725744724073e-19 NA NA NA hsa-miR-424-5p MYLK 1.61930224569578 1.89642549274994e-10 -3.91755634527497 1.71047666943349e-18 MirTarget;miRNATAP -0.29719433992386 0.000634801444390317 NA NA NA hsa-miR-429 MYLK 4.48815175680773 2.44117492218206e-17 -3.91755634527497 1.71047666943349e-18 PITA;miRanda;miRNATAP -0.493949232662281 1.40981562735827e-40 NA NA NA hsa-miR-486-5p MYLK -0.194913133034028 0.607377798807705 -3.91755634527497 1.71047666943349e-18 miRanda -0.251045470881439 2.21236986319586e-05 NA NA NA hsa-miR-501-5p MYLK 1.93654809410041 1.3779381780759e-10 -3.91755634527497 1.71047666943349e-18 MirTarget;PITA;miRNATAP -0.494379325277454 2.14712381987401e-11 NA NA NA hsa-miR-576-5p MYLK 2.20467023993664 3.4053475193793e-19 -3.91755634527497 1.71047666943349e-18 PITA;mirMAP -0.975040833380575 4.89046854857551e-33 NA NA NA hsa-miR-582-5p MYLK 0.609226359812689 0.032988717891497 -3.91755634527497 1.71047666943349e-18 PITA;mirMAP -0.520486706377831 1.730246977219e-11 NA NA NA hsa-miR-589-3p MYLK 2.51971841868825 2.39125940264107e-11 -3.91755634527497 1.71047666943349e-18 mirMAP -0.572997505260217 2.44329356954368e-19 NA NA NA hsa-miR-590-3p MYLK 2.59289455139753 1.03200520972022e-21 -3.91755634527497 1.71047666943349e-18 MirTarget;miRanda;mirMAP -0.848191229220407 1.04773319193505e-28 NA NA NA hsa-miR-590-5p MYLK 3.18300989862077 2.06813568597893e-26 -3.91755634527497 1.71047666943349e-18 miRanda -0.854826192672987 9.1770120952746e-38 NA NA NA hsa-miR-708-3p MYLK 2.80907765282502 3.07460722669281e-14 -3.91755634527497 1.71047666943349e-18 mirMAP -0.217561444382471 0.000219031809620037 NA NA NA hsa-miR-9-5p MYLK 1.02304182473283 0.042901377604859 -3.91755634527497 1.71047666943349e-18 miRNAWalker2_validate -0.170626094599343 0.000118590806256808 NA NA NA hsa-miR-944 MYLK 2.91186649218281 1.31574753528144e-06 -3.91755634527497 1.71047666943349e-18 mirMAP -0.351216285683122 3.92194129248599e-22 NA NA NA hsa-let-7a-5p NID2 0.618599506841644 2.76973453058748e-05 -0.258478441141858 0.47664424728846 miRNAWalker2_validate;TargetScan;miRNATAP -0.70843384395282 2.36938972078802e-09 NA NA NA hsa-let-7e-5p NID2 0.860104282510173 6.04758298373779e-05 -0.258478441141858 0.47664424728846 miRNATAP -0.274254415714922 0.000789966981001449 NA NA NA hsa-miR-101-3p NID2 0.522819989585461 0.00375627731618038 -0.258478441141858 0.47664424728846 miRNATAP -0.643516428955314 2.23638783458217e-11 NA NA NA hsa-miR-125a-5p NID2 0.599529391575274 0.0102300147180307 -0.258478441141858 0.47664424728846 miRanda -0.307566040901224 4.1952730705068e-05 NA NA NA hsa-miR-129-5p NID2 -0.524170159980738 0.222582956006346 -0.258478441141858 0.47664424728846 PITA;miRanda;miRNATAP -0.167628341869236 5.20302684206157e-05 NA NA NA hsa-miR-144-3p NID2 0.658119849508907 0.146943823997989 -0.258478441141858 0.47664424728846 miRNATAP -0.129547225336649 0.00114125185618306 NA NA NA hsa-miR-181d-5p NID2 1.52204912185579 9.2693319057748e-08 -0.258478441141858 0.47664424728846 miRNAWalker2_validate -0.235567413146733 0.000102211151040948 NA NA NA hsa-miR-30c-5p NID2 0.778774633108 0.000285599212429136 -0.258478441141858 0.47664424728846 miRNATAP -0.577652454282929 4.60864193307389e-13 NA NA NA hsa-miR-30d-5p NID2 0.675423997639582 0.00270618816039773 -0.258478441141858 0.47664424728846 miRNATAP -0.665554926450746 7.3520442044006e-19 NA NA NA hsa-miR-361-5p NID2 0.971859117235239 5.30236555707088e-09 -0.258478441141858 0.47664424728846 miRanda -0.759039000556177 1.21348951106168e-13 NA NA NA hsa-miR-590-3p NID2 2.59289455139753 1.03200520972022e-21 -0.258478441141858 0.47664424728846 miRanda;mirMAP -0.265490978657697 2.57655433180383e-05 NA NA NA hsa-miR-590-5p NID2 3.18300989862077 2.06813568597893e-26 -0.258478441141858 0.47664424728846 miRanda -0.24160115653104 1.77235370155132e-05 NA NA NA hsa-miR-98-5p NNMT 1.11154309866014 1.24143909012085e-08 -1.13316102834457 0.0320109449144277 miRNAWalker2_validate -1.00391537520997 1.75152405126175e-15 NA NA NA hsa-miR-103a-3p NOTCH2 1.44083190496858 1.53799939616416e-13 -0.649665466220466 0.00179668614494204 MirTarget -0.385027157118618 4.89264180444208e-15 NA NA NA hsa-miR-107 NOTCH2 1.30977326593435 1.30372468603965e-11 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.186403038708343 0.000277603211120417 NA NA NA hsa-miR-1226-3p NOTCH2 1.38118928579963 0.000205503474787488 -0.649665466220466 0.00179668614494204 MirTarget -0.180017706381832 3.06138695912041e-09 NA NA NA hsa-miR-125a-5p NOTCH2 0.599529391575274 0.0102300147180307 -0.649665466220466 0.00179668614494204 miRanda -0.285076782974206 1.95022168914584e-11 NA NA NA hsa-miR-126-5p NOTCH2 0.895338176458417 2.33372756450713e-05 -0.649665466220466 0.00179668614494204 mirMAP -0.139863687612872 0.0033475533373779 NA NA NA hsa-miR-1287-5p NOTCH2 0.712189050180771 0.00496124953411707 -0.649665466220466 0.00179668614494204 MirTarget -0.221253189180788 1.86802532818813e-08 NA NA NA hsa-miR-130b-5p NOTCH2 2.9963110846538 1.98883029416455e-18 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate;MirTarget -0.153835840036451 8.41323127308502e-08 NA NA NA hsa-miR-15a-5p NOTCH2 2.34669284378787 1.69544424500258e-23 -0.649665466220466 0.00179668614494204 MirTarget -0.24278405645845 1.52578738666268e-09 NA NA NA hsa-miR-15b-5p NOTCH2 1.57112623124278 9.14247846750597e-13 -0.649665466220466 0.00179668614494204 MirTarget -0.156336983702317 0.000490103910407743 NA NA NA hsa-miR-16-1-3p NOTCH2 2.56983217111073 3.02262181237943e-20 -0.649665466220466 0.00179668614494204 mirMAP -0.214011373235441 9.43694218750785e-10 NA NA NA hsa-miR-16-5p NOTCH2 1.75824877145857 1.68592440033108e-16 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate;MirTarget -0.14897245246307 0.00116209079289457 NA NA NA hsa-miR-17-5p NOTCH2 3.2710598467455 9.93128340539455e-27 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate -0.152560497773471 6.83361684222724e-07 NA NA NA hsa-miR-181a-5p NOTCH2 2.29556023480783 1.8138457900616e-21 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate;MirTarget;mirMAP -0.143905947369735 0.000306255276064331 NA NA NA hsa-miR-181b-5p NOTCH2 2.49307679431293 3.92829250217627e-20 -0.649665466220466 0.00179668614494204 MirTarget;mirMAP -0.101485374256876 0.00437126750456582 NA NA NA hsa-miR-181c-5p NOTCH2 1.58587920618301 1.57506918816933e-10 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate;MirTarget -0.200795801939749 3.99989183416027e-07 26983574;25494473 This is supported by the depletion of CTCF in glioblastoma cells affecting the expression levels of NOTCH2 as a target of miR-181c;Finally investigation of the mechanism defined Notch2 a key molecular of Notch signaling as the functional downstream target of miR-181c; An inverse correlation was found between miR-181c and Notch2 in glioma cells and verified in fresh glioma samples; miR-181c acts as a tumor suppressor that attenuates proliferation invasion and self-renewal capacities by downregulation of Notch2 in glioma cells ; glioblastoma;glioblastoma hsa-miR-181d-5p NOTCH2 1.52204912185579 9.2693319057748e-08 -0.649665466220466 0.00179668614494204 MirTarget -0.138792239818146 6.87384671317554e-05 NA NA NA hsa-miR-183-5p NOTCH2 4.19757025992371 4.79612296318304e-26 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate -0.186602968297905 5.5780628899393e-16 NA NA NA hsa-miR-185-5p NOTCH2 2.34016206907488 1.17481626642022e-26 -0.649665466220466 0.00179668614494204 MirTarget -0.204552118195307 2.15972303784963e-06 NA NA NA hsa-miR-186-5p NOTCH2 1.47445398888668 3.0781726595413e-15 -0.649665466220466 0.00179668614494204 mirMAP -0.201441923529323 0.000127689480699954 NA NA NA hsa-miR-1976 NOTCH2 2.06550563678192 7.81396978619772e-18 -0.649665466220466 0.00179668614494204 MirTarget -0.124112621826353 0.00219527300042677 NA NA NA hsa-miR-200a-5p NOTCH2 3.86316681673704 1.81076942093171e-15 -0.649665466220466 0.00179668614494204 mirMAP -0.166597860648776 5.22317888688301e-18 NA NA NA hsa-miR-200b-5p NOTCH2 2.54484902707822 1.59240467582976e-06 -0.649665466220466 0.00179668614494204 mirMAP -0.127387401123288 9.89946271244752e-10 NA NA NA hsa-miR-218-5p NOTCH2 -0.573801507392184 0.0551983860126703 -0.649665466220466 0.00179668614494204 MirTarget -0.106706254879182 0.00156651729499553 NA NA NA hsa-miR-25-3p NOTCH2 1.36472605225697 4.83790725935681e-11 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate -0.235507292382318 6.99856340019178e-07 NA NA NA hsa-miR-29b-3p NOTCH2 1.65828197923813 1.02676780888141e-09 -0.649665466220466 0.00179668614494204 MirTarget -0.181147718871655 5.5488985197182e-07 NA NA NA hsa-miR-29c-3p NOTCH2 -0.00968972577705429 0.97099586346872 -0.649665466220466 0.00179668614494204 MirTarget -0.239154701374818 1.53817800348435e-10 NA NA NA hsa-miR-30b-5p NOTCH2 0.800822374912712 0.000133601914525413 -0.649665466220466 0.00179668614494204 mirMAP -0.232727292147951 1.12596822430001e-06 NA NA NA hsa-miR-30c-5p NOTCH2 0.778774633108 0.000285599212429136 -0.649665466220466 0.00179668614494204 mirMAP -0.319400564697518 3.98998595021957e-12 NA NA NA hsa-miR-330-5p NOTCH2 1.15100069700871 4.85551805046014e-07 -0.649665466220466 0.00179668614494204 miRanda -0.154881641831788 0.000397591981275668 NA NA NA hsa-miR-33a-3p NOTCH2 1.72765312072219 1.51784443453521e-07 -0.649665466220466 0.00179668614494204 mirMAP -0.130723275459085 8.00200355591103e-05 NA NA NA hsa-miR-34a-5p NOTCH2 1.9016323452565 1.43092834643601e-14 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate;miRNATAP -0.276940453993645 8.61027725147104e-13 NA NA NA hsa-miR-421 NOTCH2 1.17791565395543 6.78526676976629e-06 -0.649665466220466 0.00179668614494204 miRanda -0.100618572129141 0.0088783333309056 NA NA NA hsa-miR-423-5p NOTCH2 0.963563145758616 9.86109015204915e-07 -0.649665466220466 0.00179668614494204 MirTarget -0.331032007834697 4.01952499018491e-11 NA NA NA hsa-miR-429 NOTCH2 4.48815175680773 2.44117492218206e-17 -0.649665466220466 0.00179668614494204 miRNATAP -0.151607627697974 6.20704896816715e-18 NA NA NA hsa-miR-590-5p NOTCH2 3.18300989862077 2.06813568597893e-26 -0.649665466220466 0.00179668614494204 miRanda -0.134955252568244 3.1234931315982e-05 NA NA NA hsa-miR-7-1-3p NOTCH2 1.84950311431067 1.25300363397654e-13 -0.649665466220466 0.00179668614494204 MirTarget;mirMAP -0.138111975343218 0.000445216009393343 NA NA NA hsa-miR-744-5p NOTCH2 1.48254348878737 3.23019501613577e-09 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate -0.146204505023555 0.000223560181573343 NA NA NA hsa-miR-92a-3p NOTCH2 2.06460102658973 1.44784291084757e-19 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate -0.191557194378095 5.6995060744795e-06 NA NA NA hsa-miR-940 NOTCH2 3.21011374578759 2.7923171128495e-14 -0.649665466220466 0.00179668614494204 MirTarget -0.115085878309908 4.5104844354942e-06 NA NA NA hsa-miR-125a-5p NT5E 0.599529391575274 0.0102300147180307 -1.32095136217544 0.00557630949266939 miRanda -0.35305832961467 0.000372808541660339 NA NA NA hsa-miR-148a-5p NT5E 1.16173838132242 0.000148929299881612 -1.32095136217544 0.00557630949266939 miRNATAP -0.414563810269576 2.22409192510087e-08 NA NA NA hsa-miR-28-5p NT5E 0.230152919654905 0.0742909586754846 -1.32095136217544 0.00557630949266939 miRanda -0.823725645066155 7.49568762265715e-06 NA NA NA hsa-miR-30c-5p NT5E 0.778774633108 0.000285599212429136 -1.32095136217544 0.00557630949266939 miRNATAP -0.667018140315508 3.13669638617582e-10 NA NA NA hsa-miR-30d-5p NT5E 0.675423997639582 0.00270618816039773 -1.32095136217544 0.00557630949266939 miRNATAP -0.750282446609291 7.06792165448764e-14 NA NA NA hsa-miR-335-3p NT5E 3.08791651139852 5.31309869723517e-12 -1.32095136217544 0.00557630949266939 mirMAP -0.217127985016517 1.37163094522533e-05 NA NA NA hsa-miR-34a-5p NT5E 1.9016323452565 1.43092834643601e-14 -1.32095136217544 0.00557630949266939 miRNAWalker2_validate -0.409646516674786 5.76417595066467e-06 NA NA NA hsa-miR-3607-3p NT5E 2.68532138541128 5.66716351955047e-14 -1.32095136217544 0.00557630949266939 mirMAP -0.247810164738563 0.000113938652551051 NA NA NA hsa-miR-374a-5p NT5E 0.484615721953736 0.0042981729815149 -1.32095136217544 0.00557630949266939 mirMAP -0.555029816572203 5.36491960185537e-05 NA NA NA hsa-miR-590-3p NT5E 2.59289455139753 1.03200520972022e-21 -1.32095136217544 0.00557630949266939 PITA;miRanda -0.300194924340937 0.00031894014548589 NA NA NA hsa-miR-590-5p NT5E 3.18300989862077 2.06813568597893e-26 -1.32095136217544 0.00557630949266939 miRanda -0.385241513490375 1.80409281352977e-07 NA NA NA hsa-miR-129-5p NTM -0.524170159980738 0.222582956006346 -0.0757758455544759 0.858274223904391 miRanda;miRNATAP -0.23162496093702 1.55050295692121e-06 NA NA NA hsa-miR-130b-5p NTM 2.9963110846538 1.98883029416455e-18 -0.0757758455544759 0.858274223904391 miRNATAP -0.320187913921734 3.87130755679365e-08 NA NA NA hsa-miR-182-5p NTM 3.53923166221814 5.07781258121574e-21 -0.0757758455544759 0.858274223904391 miRTarBase -0.219419953630614 2.06309065493846e-05 NA NA NA hsa-miR-30b-3p NTM 0.834142820354026 0.000972582820878813 -0.0757758455544759 0.858274223904391 MirTarget -0.493339484647855 7.10062237676421e-10 NA NA NA hsa-miR-30c-5p NTM 0.778774633108 0.000285599212429136 -0.0757758455544759 0.858274223904391 miRNATAP -0.558526652123144 3.0468054482341e-09 NA NA NA hsa-miR-30d-5p NTM 0.675423997639582 0.00270618816039773 -0.0757758455544759 0.858274223904391 miRNATAP -0.719940227498433 3.50005746925648e-16 NA NA NA hsa-miR-339-5p NTM 2.68710938429893 3.03134080808154e-16 -0.0757758455544759 0.858274223904391 miRanda -0.223092516902864 0.000196584751550324 NA NA NA hsa-miR-33a-3p NTM 1.72765312072219 1.51784443453521e-07 -0.0757758455544759 0.858274223904391 mirMAP -0.507006780496281 1.07022536027517e-14 NA NA NA hsa-miR-361-5p NTM 0.971859117235239 5.30236555707088e-09 -0.0757758455544759 0.858274223904391 MirTarget;miRanda;miRNATAP -0.819172737380491 9.3582315758244e-12 NA NA NA hsa-miR-429 NTM 4.48815175680773 2.44117492218206e-17 -0.0757758455544759 0.858274223904391 miRanda;miRNATAP -0.167166411886622 5.60688051378507e-06 NA NA NA hsa-miR-940 NTM 3.21011374578759 2.7923171128495e-14 -0.0757758455544759 0.858274223904391 miRNATAP -0.284176765115562 2.00877834263159e-08 NA NA NA hsa-miR-942-5p NTM 2.35195531153712 5.45059325728841e-16 -0.0757758455544759 0.858274223904391 MirTarget -0.354769911042983 1.44485032314771e-07 NA NA NA hsa-miR-29c-3p OXTR -0.00968972577705429 0.97099586346872 1.24842510060846 0.00107872822837734 miRNATAP -0.221503721877906 0.00154344065070416 NA NA NA hsa-miR-944 OXTR 2.91186649218281 1.31574753528144e-06 1.24842510060846 0.00107872822837734 mirMAP -0.157422363242937 4.07622055327344e-07 NA NA NA hsa-miR-130b-5p PCOLCE2 2.9963110846538 1.98883029416455e-18 -4.92842826125534 3.75529487642829e-16 MirTarget -0.524200538741723 1.08995161291414e-09 NA NA NA hsa-miR-182-5p PCOLCE2 3.53923166221814 5.07781258121574e-21 -4.92842826125534 3.75529487642829e-16 miRNAWalker2_validate -0.73624117085977 4.47098337633947e-24 NA NA NA hsa-miR-192-5p PCOLCE2 2.69002528723195 1.22990188194432e-16 -4.92842826125534 3.75529487642829e-16 miRNAWalker2_validate -0.606048286267009 5.91028475860049e-12 NA NA NA hsa-miR-215-5p PCOLCE2 2.30755467422978 2.38476032118039e-06 -4.92842826125534 3.75529487642829e-16 miRNAWalker2_validate -0.270507643256401 1.6610105405234e-05 NA NA NA hsa-miR-25-3p PCOLCE2 1.36472605225697 4.83790725935681e-11 -4.92842826125534 3.75529487642829e-16 MirTarget -0.534340262848267 0.000202363574605866 NA NA NA hsa-miR-26b-5p PCOLCE2 0.885393662798425 3.2116297961629e-06 -4.92842826125534 3.75529487642829e-16 miRNAWalker2_validate -1.06981263204918 7.75950385839484e-12 NA NA NA hsa-miR-32-5p PCOLCE2 2.34056473219422 6.24134585974322e-20 -4.92842826125534 3.75529487642829e-16 MirTarget -0.808597377048111 2.83628714621752e-13 NA NA NA hsa-miR-501-5p PCOLCE2 1.93654809410041 1.3779381780759e-10 -4.92842826125534 3.75529487642829e-16 MirTarget;PITA -0.376546346135508 0.000201254597168614 NA NA NA hsa-miR-590-3p PCOLCE2 2.59289455139753 1.03200520972022e-21 -4.92842826125534 3.75529487642829e-16 MirTarget;miRanda -0.603239174473175 2.63268512221241e-08 NA NA NA hsa-miR-92a-3p PCOLCE2 2.06460102658973 1.44784291084757e-19 -4.92842826125534 3.75529487642829e-16 MirTarget -0.678109841691066 8.24470535690164e-08 NA NA NA hsa-miR-224-5p PDGFRB 2.94107125335675 5.72194099515157e-08 -1.03522303801072 0.00301738788961229 miRNAWalker2_validate -0.147943334000896 1.16237114575095e-06 NA NA NA hsa-miR-24-3p PDGFRB 0.99989036772428 1.35595013650376e-07 -1.03522303801072 0.00301738788961229 MirTarget -0.297654000867495 0.000814454894038923 NA NA NA hsa-miR-29b-3p PDGFRB 1.65828197923813 1.02676780888141e-09 -1.03522303801072 0.00301738788961229 miRNATAP -0.292671948645054 1.48415268440158e-06 NA NA NA hsa-miR-29c-3p PDGFRB -0.00968972577705429 0.97099586346872 -1.03522303801072 0.00301738788961229 miRNATAP -0.359274369001045 1.19150158465265e-08 NA NA NA hsa-miR-3127-5p PDGFRB 1.51846438737133 3.59571251672767e-07 -1.03522303801072 0.00301738788961229 mirMAP -0.437942367228042 7.35571780732733e-16 NA NA NA hsa-miR-34a-5p PDGFRB 1.9016323452565 1.43092834643601e-14 -1.03522303801072 0.00301738788961229 MirTarget -0.3682858109356 2.13745951637981e-08 24837198 MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway metastasis gastric cancer hsa-miR-361-3p PDGFRB 1.07367425434318 1.73142774168958e-09 -1.03522303801072 0.00301738788961229 MirTarget -0.272631369423021 0.00390272618180474 NA NA NA hsa-miR-421 PDGFRB 1.17791565395543 6.78526676976629e-06 -1.03522303801072 0.00301738788961229 miRanda -0.344304119846965 6.47537980961128e-08 NA NA NA hsa-miR-484 PDGFRB 1.81844463411787 1.82951571230938e-15 -1.03522303801072 0.00301738788961229 mirMAP -0.430712318832622 1.16944218559625e-09 NA NA NA hsa-miR-486-5p PDGFRB -0.194913133034028 0.607377798807705 -1.03522303801072 0.00301738788961229 miRanda -0.172192912820644 0.000110418260727812 NA NA NA hsa-miR-491-5p PDGFRB 0.615770352820862 0.0418295628761654 -1.03522303801072 0.00301738788961229 miRanda -0.236736729792446 7.68579463655803e-05 NA NA NA hsa-miR-664a-3p PDGFRB 0.634721925861133 0.00520070178640421 -1.03522303801072 0.00301738788961229 MirTarget -0.524307398841617 6.92902562319671e-13 NA NA NA hsa-miR-9-5p PDGFRB 1.02304182473283 0.042901377604859 -1.03522303801072 0.00301738788961229 MirTarget;miRNATAP -0.128055325842353 0.000120423195513495 NA NA NA hsa-miR-28-5p PDLIM4 0.230152919654905 0.0742909586754846 -1.98288500289907 1.773551695518e-05 miRanda -0.489053947909642 0.0068216284814202 NA NA NA hsa-miR-320a PDLIM4 0.438165828017084 0.0390159073347133 -1.98288500289907 1.773551695518e-05 mirMAP -0.481505126942323 5.96574910163199e-06 NA NA NA hsa-miR-320b PDLIM4 1.55692969039548 1.41071034251915e-08 -1.98288500289907 1.773551695518e-05 mirMAP -0.400624467654692 6.00359399179893e-07 NA NA NA hsa-miR-324-5p PDLIM4 2.95683728155095 1.32960514360912e-20 -1.98288500289907 1.773551695518e-05 miRanda -0.490243578048172 1.00286379053701e-13 NA NA NA hsa-miR-326 PDLIM4 0.715313016136042 0.0610265683213359 -1.98288500289907 1.773551695518e-05 miRanda -0.277554474235099 2.39069467840133e-06 NA NA NA hsa-miR-330-5p PDLIM4 1.15100069700871 4.85551805046014e-07 -1.98288500289907 1.773551695518e-05 miRanda -0.584779828982395 1.29273097483211e-09 NA NA NA hsa-miR-335-5p PDLIM4 1.77247705492746 2.22457658872091e-06 -1.98288500289907 1.773551695518e-05 miRNAWalker2_validate -0.28721031002715 1.12147229395073e-06 NA NA NA hsa-miR-150-5p PFN2 -0.105827294491332 0.799351458244375 0.329348857729314 0.190782648111049 miRNATAP -0.106457494987833 0.000258295993950203 NA NA NA hsa-miR-30a-5p PFN2 -0.878357906436456 0.000509952992366057 0.329348857729314 0.190782648111049 MirTarget;miRNATAP -0.166426611946718 0.000522570294477119 NA NA NA hsa-miR-23b-3p PLOD1 -0.251132426825047 0.150200321210792 0.839810096515485 3.81987076026623e-06 miRNAWalker2_validate -0.156429772139039 0.00242995670062527 NA NA NA hsa-miR-126-5p PLOD2 0.895338176458417 2.33372756450713e-05 0.408783051727277 0.223517816964063 mirMAP -0.271989458985555 0.000375619776124661 NA NA NA hsa-miR-182-5p PLOD2 3.53923166221814 5.07781258121574e-21 0.408783051727277 0.223517816964063 miRNATAP -0.264029735377106 5.17442693519629e-11 NA NA NA hsa-miR-183-5p PLOD2 4.19757025992371 4.79612296318304e-26 0.408783051727277 0.223517816964063 miRNAWalker2_validate -0.214396141295388 1.3865787925725e-08 NA NA NA hsa-miR-186-5p PLOD2 1.47445398888668 3.0781726595413e-15 0.408783051727277 0.223517816964063 mirMAP -0.235372339543063 0.0055678706987072 NA NA NA hsa-miR-26b-5p PLOD2 0.885393662798425 3.2116297961629e-06 0.408783051727277 0.223517816964063 miRNAWalker2_validate;MirTarget;miRNATAP -0.259726704254499 0.00234974251433044 27310702;26983694 Tumour suppressive miRNA 26a 5p and miR 26b 5p inhibit cell aggressiveness by regulating PLOD2 in bladder cancer; The gene encoding procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 PLOD2 a collagen crosslinking enzyme was directly regulated by miR-26a-5p and miR-26b-5p; PLOD2 which is associated with the stiffness of the extracellular matrix was directly regulated by miR-26a-5p and miR-26b-5p and may be a good prognostic marker in patients with BC;Thus our data showed that two genes promoting metastasis LOXL2 and PLOD2 were epigenetically regulated by tumor-suppressive microRNAs miR-26a and miR-26b providing important insights into the molecular mechanisms of RCC metastasis ;metastasis bladder cancer;kidney renal cell cancer hsa-miR-335-3p PLOD2 3.08791651139852 5.31309869723517e-12 0.408783051727277 0.223517816964063 MirTarget;mirMAP -0.177602062699639 3.60207824777485e-07 NA NA NA hsa-miR-425-5p PLOD2 3.07071373939774 4.02947460586085e-25 0.408783051727277 0.223517816964063 miRNAWalker2_validate -0.212380601294972 3.55397374060836e-05 NA NA NA hsa-miR-429 PLOD2 4.48815175680773 2.44117492218206e-17 0.408783051727277 0.223517816964063 miRanda -0.222828675106892 4.992378445287e-15 NA NA NA hsa-miR-590-3p PLOD2 2.59289455139753 1.03200520972022e-21 0.408783051727277 0.223517816964063 miRanda -0.154517992998684 0.00852605904135829 NA NA NA hsa-miR-96-5p PLOD2 4.89433085814374 1.92000659886961e-31 0.408783051727277 0.223517816964063 MirTarget;TargetScan;miRNATAP -0.194758858103316 8.39395905996987e-08 NA NA NA hsa-miR-98-5p PLOD2 1.11154309866014 1.24143909012085e-08 0.408783051727277 0.223517816964063 miRNAWalker2_validate -0.535725976574921 3.53177908633716e-11 NA NA NA hsa-miR-103a-2-5p PMEPA1 2.47599305985086 7.933028987326e-11 0.496709150118967 0.234971975822272 mirMAP -0.184921875363826 0.00163090522052503 NA NA NA hsa-miR-103a-3p PMEPA1 1.44083190496858 1.53799939616416e-13 0.496709150118967 0.234971975822272 mirMAP -0.747222798539842 3.77754385973818e-14 NA NA NA hsa-miR-107 PMEPA1 1.30977326593435 1.30372468603965e-11 0.496709150118967 0.234971975822272 mirMAP -0.712237644728097 1.37247404347828e-12 NA NA NA hsa-miR-10a-5p PMEPA1 1.15016989191194 0.00372037233992369 0.496709150118967 0.234971975822272 mirMAP -0.306023436515456 8.7589921768872e-10 NA NA NA hsa-miR-10b-5p PMEPA1 -0.155951595811628 0.555006386998027 0.496709150118967 0.234971975822272 mirMAP -0.468094327749622 5.92891748743313e-10 NA NA NA hsa-miR-129-5p PMEPA1 -0.524170159980738 0.222582956006346 0.496709150118967 0.234971975822272 MirTarget;miRanda;miRNATAP -0.161239548516004 0.000758765182291873 NA NA NA hsa-miR-130b-3p PMEPA1 3.5350292994509 1.73934183852569e-27 0.496709150118967 0.234971975822272 MirTarget;miRNATAP -0.222057261156225 0.000128237728395848 NA NA NA hsa-miR-15a-5p PMEPA1 2.34669284378787 1.69544424500258e-23 0.496709150118967 0.234971975822272 mirMAP -0.257590372831801 0.00162924288122937 NA NA NA hsa-miR-15b-5p PMEPA1 1.57112623124278 9.14247846750597e-13 0.496709150118967 0.234971975822272 mirMAP -0.635970668285271 4.18241113240614e-13 NA NA NA hsa-miR-16-5p PMEPA1 1.75824877145857 1.68592440033108e-16 0.496709150118967 0.234971975822272 mirMAP -0.405861541540682 8.92072730164736e-06 NA NA NA hsa-miR-19b-3p PMEPA1 2.49529833021187 1.57028265846699e-23 0.496709150118967 0.234971975822272 MirTarget;miRNATAP -0.285381818896633 0.00019778198166205 NA NA NA hsa-miR-301a-3p PMEPA1 2.81024345929638 2.29784847962242e-17 0.496709150118967 0.234971975822272 MirTarget;miRNATAP -0.357550756208507 4.79708411756812e-09 NA NA NA hsa-miR-32-5p PMEPA1 2.34056473219422 6.24134585974322e-20 0.496709150118967 0.234971975822272 miRNATAP -0.373326108700494 6.27251741365783e-07 NA NA NA hsa-miR-320a PMEPA1 0.438165828017084 0.0390159073347133 0.496709150118967 0.234971975822272 mirMAP -0.490257793302104 2.42904867232476e-07 NA NA NA hsa-miR-320b PMEPA1 1.55692969039548 1.41071034251915e-08 0.496709150118967 0.234971975822272 mirMAP -0.310161252839585 1.74069018060762e-05 NA NA NA hsa-miR-335-3p PMEPA1 3.08791651139852 5.31309869723517e-12 0.496709150118967 0.234971975822272 MirTarget -0.126001595359043 0.00412632797877972 NA NA NA hsa-miR-335-5p PMEPA1 1.77247705492746 2.22457658872091e-06 0.496709150118967 0.234971975822272 mirMAP -0.159883811494573 0.00271173984481437 NA NA NA hsa-miR-421 PMEPA1 1.17791565395543 6.78526676976629e-06 0.496709150118967 0.234971975822272 miRanda -0.386394181838128 3.91731879788174e-07 NA NA NA hsa-miR-429 PMEPA1 4.48815175680773 2.44117492218206e-17 0.496709150118967 0.234971975822272 miRNATAP -0.284680697921745 8.71856440286838e-16 NA NA NA hsa-miR-454-3p PMEPA1 2.47234127820054 1.12878018736016e-21 0.496709150118967 0.234971975822272 MirTarget;miRNATAP -0.319415858817584 2.80171957179938e-05 NA NA NA hsa-miR-486-5p PMEPA1 -0.194913133034028 0.607377798807705 0.496709150118967 0.234971975822272 miRanda -0.159965173263302 0.00270420139146388 NA NA NA hsa-miR-532-3p PMEPA1 1.96631878320218 4.53421954361695e-13 0.496709150118967 0.234971975822272 mirMAP -0.438412499872993 7.80622709800953e-10 NA NA NA hsa-miR-582-5p PMEPA1 0.609226359812689 0.032988717891497 0.496709150118967 0.234971975822272 miRNATAP -0.271966354637684 0.000117210411602503 NA NA NA hsa-miR-589-5p PMEPA1 1.71990116752371 8.310889042056e-14 0.496709150118967 0.234971975822272 mirMAP -0.316668428834164 0.000207235726946864 NA NA NA hsa-miR-7-1-3p PMEPA1 1.84950311431067 1.25300363397654e-13 0.496709150118967 0.234971975822272 mirMAP -0.304379405932831 0.000108884445192963 NA NA NA hsa-miR-92a-3p PMEPA1 2.06460102658973 1.44784291084757e-19 0.496709150118967 0.234971975822272 miRNATAP -0.440822507998795 1.66125815355108e-07 NA NA NA hsa-miR-940 PMEPA1 3.21011374578759 2.7923171128495e-14 0.496709150118967 0.234971975822272 miRNATAP -0.32074590321248 1.05160959603004e-10 NA NA NA hsa-miR-96-5p PMEPA1 4.89433085814374 1.92000659886961e-31 0.496709150118967 0.234971975822272 TargetScan -0.235546779833539 2.02060443106482e-07 NA NA NA hsa-miR-129-5p PMP22 -0.524170159980738 0.222582956006346 -2.41501664380434 2.119332560979e-10 miRanda -0.14761656202954 0.000917586576711521 NA NA NA hsa-miR-26b-5p PMP22 0.885393662798425 3.2116297961629e-06 -2.41501664380434 2.119332560979e-10 miRNAWalker2_validate -0.471301393328408 1.55044055360965e-06 NA NA NA hsa-miR-29b-3p PMP22 1.65828197923813 1.02676780888141e-09 -2.41501664380434 2.119332560979e-10 MirTarget;miRNATAP -0.185228197848823 0.00653012170109258 NA NA NA hsa-miR-30b-3p PMP22 0.834142820354026 0.000972582820878813 -2.41501664380434 2.119332560979e-10 MirTarget -0.403444488035314 4.5088318742233e-08 NA NA NA hsa-miR-330-3p PMP22 0.876747334239085 0.00073709016089703 -2.41501664380434 2.119332560979e-10 PITA -0.372613843372395 1.89023385081524e-07 NA NA NA hsa-miR-361-5p PMP22 0.971859117235239 5.30236555707088e-09 -2.41501664380434 2.119332560979e-10 miRanda -0.672025222099847 1.34552182372484e-09 NA NA NA hsa-miR-429 PMP22 4.48815175680773 2.44117492218206e-17 -2.41501664380434 2.119332560979e-10 PITA;miRanda;miRNATAP -0.282527887280216 5.94687301369815e-18 NA NA NA hsa-miR-505-3p PMP22 1.45322244209148 8.86597629645867e-10 -2.41501664380434 2.119332560979e-10 MirTarget;miRNATAP -0.262640549883004 0.000759918788600817 NA NA NA hsa-miR-582-5p PMP22 0.609226359812689 0.032988717891497 -2.41501664380434 2.119332560979e-10 PITA;miRNATAP -0.390737248608487 1.67182369833006e-09 NA NA NA hsa-miR-590-3p PMP22 2.59289455139753 1.03200520972022e-21 -2.41501664380434 2.119332560979e-10 miRanda -0.288911408529138 1.91406747612206e-05 NA NA NA hsa-miR-651-5p PMP22 2.32951837918862 1.62508965949028e-11 -2.41501664380434 2.119332560979e-10 MirTarget -0.386712814150945 3.94366989208763e-11 NA NA NA hsa-miR-9-5p PMP22 1.02304182473283 0.042901377604859 -2.41501664380434 2.119332560979e-10 MirTarget;miRNATAP -0.109608447855696 0.00312111038599097 NA NA NA hsa-miR-944 PMP22 2.91186649218281 1.31574753528144e-06 -2.41501664380434 2.119332560979e-10 PITA;mirMAP -0.264469642714563 5.42053349788019e-18 NA NA NA hsa-miR-129-5p POSTN -0.524170159980738 0.222582956006346 0.34890519405657 0.627468743238865 miRanda -0.447832731329433 3.72084667173378e-08 NA NA NA hsa-miR-185-5p POSTN 2.34016206907488 1.17481626642022e-26 0.34890519405657 0.627468743238865 MirTarget -0.622177969999308 2.9878923145643e-05 NA NA NA hsa-miR-335-3p POSTN 3.08791651139852 5.31309869723517e-12 0.34890519405657 0.627468743238865 mirMAP -0.211136357112858 0.00516977394824249 NA NA NA hsa-miR-590-3p POSTN 2.59289455139753 1.03200520972022e-21 0.34890519405657 0.627468743238865 mirMAP -0.394059306738237 0.00169314441286749 NA NA NA hsa-let-7a-5p PRRX1 0.618599506841644 2.76973453058748e-05 -1.17847539982928 0.0280799671619873 MirTarget;TargetScan;miRNATAP -1.37994766861812 1.50332934585788e-15 NA NA NA hsa-let-7b-5p PRRX1 0.604314269683977 0.00140009936153214 -1.17847539982928 0.0280799671619873 MirTarget;miRNATAP -0.709266967487318 2.25441849217046e-07 NA NA NA hsa-let-7d-5p PRRX1 1.33236798905207 1.1741085658466e-13 -1.17847539982928 0.0280799671619873 MirTarget;miRNATAP -0.998818706686389 6.02529413104877e-13 NA NA NA hsa-let-7e-5p PRRX1 0.860104282510173 6.04758298373779e-05 -1.17847539982928 0.0280799671619873 MirTarget;miRNATAP -0.750710728448824 2.89366006412242e-10 NA NA NA hsa-let-7f-5p PRRX1 0.495648727272215 0.00355972741198794 -1.17847539982928 0.0280799671619873 MirTarget;miRNATAP -0.847403930072566 2.94097930762022e-08 NA NA NA hsa-let-7g-5p PRRX1 1.20061455355116 1.50237505511483e-12 -1.17847539982928 0.0280799671619873 MirTarget;miRNATAP -1.42444032763649 3.51921961397177e-23 NA NA NA hsa-miR-106a-5p PRRX1 2.48882002962836 1.99757727374521e-12 -1.17847539982928 0.0280799671619873 MirTarget;miRNATAP -0.483791671670442 4.41216441065193e-12 NA NA NA hsa-miR-106b-5p PRRX1 2.46782146831112 1.36171495805632e-23 -1.17847539982928 0.0280799671619873 MirTarget;miRNATAP -0.912197656792271 1.21298539663863e-21 26617763 Down regualtion of miR 106b induces epithelial mesenchymal transition but suppresses metastatic colonization by targeting Prrx1 in colorectal cancer; We identified Prrx1 was a direct target of miR-106b through using target prediction algorithms and dual-Luciferase reporter assay; Moreover Moreover we also found TGF-β1 could down-regulate miR-106b and simultaneously miR-106b also influences the expression of TGF-β1 establishing a negative feedback loop to regulate the expression of Prrx1 together colorectal cancer hsa-miR-10b-3p PRRX1 0.77597971642517 0.00264877454133753 -1.17847539982928 0.0280799671619873 miRNATAP -0.710052701220434 4.82626707819951e-13 NA NA NA hsa-miR-1226-3p PRRX1 1.38118928579963 0.000205503474787488 -1.17847539982928 0.0280799671619873 MirTarget -0.609533040725479 2.38693734739364e-15 NA NA NA hsa-miR-126-5p PRRX1 0.895338176458417 2.33372756450713e-05 -1.17847539982928 0.0280799671619873 mirMAP -0.433814957113545 0.000398122872710833 NA NA NA hsa-miR-144-3p PRRX1 0.658119849508907 0.146943823997989 -1.17847539982928 0.0280799671619873 MirTarget -0.286625588617958 9.79342990285632e-07 NA NA NA hsa-miR-148b-5p PRRX1 2.18024067300781 2.84770452413262e-14 -1.17847539982928 0.0280799671619873 MirTarget -0.751208643760209 6.23184133169061e-17 NA NA NA hsa-miR-16-2-3p PRRX1 2.31623086727196 4.29838149388188e-20 -1.17847539982928 0.0280799671619873 MirTarget -0.537822561604418 3.4068553942278e-08 NA NA NA hsa-miR-17-5p PRRX1 3.2710598467455 9.93128340539455e-27 -1.17847539982928 0.0280799671619873 MirTarget;TargetScan;miRNATAP -0.593602572062137 1.98127841086953e-14 NA NA NA hsa-miR-186-5p PRRX1 1.47445398888668 3.0781726595413e-15 -1.17847539982928 0.0280799671619873 mirMAP -0.916740267732145 5.17524784785285e-12 NA NA NA hsa-miR-1976 PRRX1 2.06550563678192 7.81396978619772e-18 -1.17847539982928 0.0280799671619873 MirTarget;miRNATAP -0.631383137932884 7.714458824667e-10 NA NA NA hsa-miR-200b-5p PRRX1 2.54484902707822 1.59240467582976e-06 -1.17847539982928 0.0280799671619873 mirMAP -0.599336507146336 2.43632420938978e-32 NA NA NA hsa-miR-20a-5p PRRX1 3.15577933619191 4.19753346442454e-25 -1.17847539982928 0.0280799671619873 MirTarget;miRNATAP -0.620341639814796 1.63143979476674e-15 NA NA NA hsa-miR-20b-5p PRRX1 2.07706563022469 1.10107236083433e-05 -1.17847539982928 0.0280799671619873 MirTarget;miRNATAP -0.373740524770099 1.93251482013924e-12 NA NA NA hsa-miR-224-3p PRRX1 1.87536386559317 6.15140969394846e-05 -1.17847539982928 0.0280799671619873 mirMAP -0.383114983336255 1.08756563092343e-11 NA NA NA hsa-miR-26b-3p PRRX1 2.18464160365372 2.11543189388328e-18 -1.17847539982928 0.0280799671619873 MirTarget -0.818517391087488 2.36866650934014e-17 NA NA NA hsa-miR-32-3p PRRX1 2.02436999565685 5.94091197945307e-09 -1.17847539982928 0.0280799671619873 mirMAP;miRNATAP -0.56662919727067 4.49790004112064e-12 NA NA NA hsa-miR-320a PRRX1 0.438165828017084 0.0390159073347133 -1.17847539982928 0.0280799671619873 miRanda -0.964665638497805 6.45563454287766e-16 NA NA NA hsa-miR-320b PRRX1 1.55692969039548 1.41071034251915e-08 -1.17847539982928 0.0280799671619873 miRanda -0.676639909771766 9.51670130427737e-14 NA NA NA hsa-miR-330-3p PRRX1 0.876747334239085 0.00073709016089703 -1.17847539982928 0.0280799671619873 PITA;miRNATAP -0.757965582455548 5.40918614775645e-15 NA NA NA hsa-miR-335-3p PRRX1 3.08791651139852 5.31309869723517e-12 -1.17847539982928 0.0280799671619873 MirTarget;mirMAP -0.27642243023514 7.79386693416942e-07 NA NA NA hsa-miR-486-5p PRRX1 -0.194913133034028 0.607377798807705 -1.17847539982928 0.0280799671619873 miRanda -0.298484073889587 1.19362701808368e-05 NA NA NA hsa-miR-576-5p PRRX1 2.20467023993664 3.4053475193793e-19 -1.17847539982928 0.0280799671619873 mirMAP -0.563861370644838 1.75110633532839e-08 NA NA NA hsa-miR-584-5p PRRX1 2.7326672683732 9.92677936962233e-12 -1.17847539982928 0.0280799671619873 MirTarget -0.444189635617119 5.03847398151756e-13 NA NA NA hsa-miR-590-3p PRRX1 2.59289455139753 1.03200520972022e-21 -1.17847539982928 0.0280799671619873 miRanda;mirMAP;miRNATAP -0.387210568241452 3.4691654041717e-05 NA NA NA hsa-miR-664a-3p PRRX1 0.634721925861133 0.00520070178640421 -1.17847539982928 0.0280799671619873 mirMAP -0.922002245436747 9.29535480669617e-17 NA NA NA hsa-miR-7-1-3p PRRX1 1.84950311431067 1.25300363397654e-13 -1.17847539982928 0.0280799671619873 mirMAP -0.431830699436381 1.88538456356888e-05 NA NA NA hsa-miR-93-5p PRRX1 3.03961860136032 1.11672209617395e-24 -1.17847539982928 0.0280799671619873 MirTarget;miRNATAP -0.80795588860723 5.53011281360458e-25 NA NA NA hsa-miR-944 PRRX1 2.91186649218281 1.31574753528144e-06 -1.17847539982928 0.0280799671619873 MirTarget;PITA;mirMAP -0.334988006671789 3.8779145423352e-15 NA NA NA hsa-miR-96-5p PRRX1 4.89433085814374 1.92000659886961e-31 -1.17847539982928 0.0280799671619873 MirTarget;TargetScan -0.484825703432371 1.28518648997954e-17 NA NA NA hsa-miR-98-5p PRRX1 1.11154309866014 1.24143909012085e-08 -1.17847539982928 0.0280799671619873 MirTarget -1.02930233193781 8.97431395189458e-16 NA NA NA hsa-miR-106a-5p PTHLH 2.48882002962836 1.99757727374521e-12 -0.637337427958821 0.359541326845111 MirTarget;miRNATAP -0.549964804518897 1.49826518016467e-09 NA NA NA hsa-miR-106b-5p PTHLH 2.46782146831112 1.36171495805632e-23 -0.637337427958821 0.359541326845111 MirTarget -0.773695653342733 1.25729781199227e-09 NA NA NA hsa-miR-107 PTHLH 1.30977326593435 1.30372468603965e-11 -0.637337427958821 0.359541326845111 miRanda -0.862280039256106 3.66268188422626e-07 NA NA NA hsa-miR-15a-5p PTHLH 2.34669284378787 1.69544424500258e-23 -0.637337427958821 0.359541326845111 MirTarget -0.451548007185152 0.000890925809434127 NA NA NA hsa-miR-15b-5p PTHLH 1.57112623124278 9.14247846750597e-13 -0.637337427958821 0.359541326845111 MirTarget -0.518760613042215 0.00051633237873539 NA NA NA hsa-miR-182-5p PTHLH 3.53923166221814 5.07781258121574e-21 -0.637337427958821 0.359541326845111 MirTarget -0.410558056926388 1.10216659777992e-06 NA NA NA hsa-miR-190a-5p PTHLH 0.762748400660219 0.0035950590410453 -0.637337427958821 0.359541326845111 MirTarget -0.75998806601105 2.08850501548594e-09 NA NA NA hsa-miR-200b-3p PTHLH 3.78235093249346 3.18343003239465e-14 -0.637337427958821 0.359541326845111 MirTarget;TargetScan -0.413700282811654 9.91284549404076e-11 NA NA NA hsa-miR-200c-3p PTHLH 3.50132673580082 2.42716349086937e-15 -0.637337427958821 0.359541326845111 MirTarget -0.321174456367142 1.03989013458563e-05 NA NA NA hsa-miR-20a-5p PTHLH 3.15577933619191 4.19753346442454e-25 -0.637337427958821 0.359541326845111 MirTarget -0.328784281123709 0.00155602547232449 NA NA NA hsa-miR-20b-5p PTHLH 2.07706563022469 1.10107236083433e-05 -0.637337427958821 0.359541326845111 MirTarget -0.543106159641618 1.54577755560045e-15 NA NA NA hsa-miR-29c-3p PTHLH -0.00968972577705429 0.97099586346872 -0.637337427958821 0.359541326845111 MirTarget -1.00410250804699 2.58790219256253e-16 NA NA NA hsa-miR-3065-3p PTHLH 2.16221780121195 9.65525739884541e-09 -0.637337427958821 0.359541326845111 MirTarget;miRNATAP -0.247796758568486 0.00469236173656213 NA NA NA hsa-miR-33a-5p PTHLH 3.79671563098419 1.15966309820345e-18 -0.637337427958821 0.359541326845111 miRNAWalker2_validate -0.22993510233072 0.00474309347427808 23458685 We have found that miR-33a which is downregulated in lung cancer cells directly targets PTHrP parathyroid hormone-related protein a potent stimulator of osteoclastic bone resorption leading to decreased osteolytic bone metastasis; We also found that miR-33a levels are inversely correlated with PTHrP expression between human normal bronchial cell line and lung cancer cell lines; These findings have led us to conclude that miR-33a may be a potent tumor suppressor which inhibits direct and indirect osteoclastogenesis through repression of PTHrP miR-33a may even predict a poor prognosis for lung cancer patients metastasis;worse prognosis lung cancer hsa-miR-429 PTHLH 4.48815175680773 2.44117492218206e-17 -0.637337427958821 0.359541326845111 MirTarget;PITA;miRanda -0.363002331524166 1.29749320071704e-09 NA NA NA hsa-miR-497-5p PTHLH 0.0257087130056286 0.918145413833358 -0.637337427958821 0.359541326845111 MirTarget -0.469645868960252 0.00050393067372097 NA NA NA hsa-miR-93-5p PTHLH 3.03961860136032 1.11672209617395e-24 -0.637337427958821 0.359541326845111 MirTarget -0.655922974387782 4.61953944999e-10 NA NA NA hsa-miR-101-3p PTX3 0.522819989585461 0.00375627731618038 -2.8851360132459 1.21456702792228e-06 miRNATAP -0.448603890066993 0.00598121566919118 NA NA NA hsa-miR-130b-5p PTX3 2.9963110846538 1.98883029416455e-18 -2.8851360132459 1.21456702792228e-06 MirTarget -0.401168104454246 1.3819422429112e-06 NA NA NA hsa-miR-224-5p PTX3 2.94107125335675 5.72194099515157e-08 -2.8851360132459 1.21456702792228e-06 MirTarget -0.184032744195005 0.000473961039196136 NA NA NA hsa-miR-29b-3p PTX3 1.65828197923813 1.02676780888141e-09 -2.8851360132459 1.21456702792228e-06 MirTarget -0.321255269485974 0.00229738072737715 NA NA NA hsa-miR-29c-3p PTX3 -0.00968972577705429 0.97099586346872 -2.8851360132459 1.21456702792228e-06 MirTarget -0.501396917843225 4.26481707019515e-06 NA NA NA hsa-miR-330-5p PTX3 1.15100069700871 4.85551805046014e-07 -2.8851360132459 1.21456702792228e-06 miRanda -0.555755203359895 9.73095139269805e-06 NA NA NA hsa-miR-582-5p PTX3 0.609226359812689 0.032988717891497 -2.8851360132459 1.21456702792228e-06 miRNATAP -0.37431749521768 0.000235323605284182 NA NA NA hsa-miR-590-3p PTX3 2.59289455139753 1.03200520972022e-21 -2.8851360132459 1.21456702792228e-06 miRanda -0.386587415577112 0.000231059843838146 NA NA NA hsa-miR-590-5p PTX3 3.18300989862077 2.06813568597893e-26 -2.8851360132459 1.21456702792228e-06 miRanda -0.447949337635295 1.53112193770888e-06 NA NA NA hsa-miR-7-1-3p PTX3 1.84950311431067 1.25300363397654e-13 -2.8851360132459 1.21456702792228e-06 mirMAP -0.420392349929942 0.000208897481506739 NA NA NA hsa-miR-944 PTX3 2.91186649218281 1.31574753528144e-06 -2.8851360132459 1.21456702792228e-06 PITA;mirMAP -0.372895708962601 5.90551900930763e-15 NA NA NA hsa-miR-30b-3p PVR 0.834142820354026 0.000972582820878813 0.693450264482034 0.00120933689453557 MirTarget -0.165195641833201 5.89848623894275e-05 NA NA NA hsa-miR-33a-3p PVR 1.72765312072219 1.51784443453521e-07 0.693450264482034 0.00120933689453557 mirMAP -0.115030138926942 0.000776953057720783 NA NA NA hsa-miR-664a-3p PVR 0.634721925861133 0.00520070178640421 0.693450264482034 0.00120933689453557 mirMAP -0.284190835919046 3.00620789844374e-10 NA NA NA hsa-miR-1271-5p QSOX1 0.970418832993172 0.000609742584380688 -0.494263019898611 0.00925793650765899 mirMAP -0.113188129222461 0.000475025339145972 NA NA NA hsa-miR-146b-5p QSOX1 1.75587235896724 1.15724631266659e-07 -0.494263019898611 0.00925793650765899 miRanda -0.106852819697902 8.80008307288682e-05 NA NA NA hsa-miR-340-5p QSOX1 0.30282999308409 0.157744789519131 -0.494263019898611 0.00925793650765899 mirMAP -0.148390668372123 0.000588714640169219 NA NA NA hsa-miR-34c-5p QSOX1 2.07190852984647 7.35776320806257e-08 -0.494263019898611 0.00925793650765899 mirMAP -0.111998736305074 6.98726712506922e-06 NA NA NA hsa-miR-590-3p QSOX1 2.59289455139753 1.03200520972022e-21 -0.494263019898611 0.00925793650765899 mirMAP -0.109302819198122 0.000990907420532809 NA NA NA hsa-miR-625-5p QSOX1 1.42540152147292 1.95797147911206e-06 -0.494263019898611 0.00925793650765899 mirMAP -0.135335923551252 4.65173865383831e-05 NA NA NA hsa-miR-629-3p QSOX1 2.36570947321815 1.33458201201618e-11 -0.494263019898611 0.00925793650765899 mirMAP -0.109135526469482 0.000160989362538715 NA NA NA hsa-miR-92a-3p QSOX1 2.06460102658973 1.44784291084757e-19 -0.494263019898611 0.00925793650765899 mirMAP -0.106561030030114 0.00595447023020141 NA NA NA hsa-miR-103a-3p RGS4 1.44083190496858 1.53799939616416e-13 -1.13727010818888 0.0248299562073108 MirTarget;miRNATAP -1.01619536428977 1.20384658475235e-17 NA NA NA hsa-miR-107 RGS4 1.30977326593435 1.30372468603965e-11 -1.13727010818888 0.0248299562073108 MirTarget;miRanda;miRNATAP -0.800356983992477 6.67520752658944e-11 NA NA NA hsa-miR-126-5p RGS4 0.895338176458417 2.33372756450713e-05 -1.13727010818888 0.0248299562073108 MirTarget;mirMAP -0.534600231675853 3.40071617734146e-06 NA NA NA hsa-miR-16-2-3p RGS4 2.31623086727196 4.29838149388188e-20 -1.13727010818888 0.0248299562073108 MirTarget;mirMAP -0.470601767988336 3.40426431103575e-07 NA NA NA hsa-miR-17-5p RGS4 3.2710598467455 9.93128340539455e-27 -1.13727010818888 0.0248299562073108 TargetScan -0.535370441414347 3.26059329177888e-13 NA NA NA hsa-miR-26b-5p RGS4 0.885393662798425 3.2116297961629e-06 -1.13727010818888 0.0248299562073108 MirTarget;miRNATAP -0.598209811746856 3.07984346923256e-06 NA NA NA hsa-miR-30b-3p RGS4 0.834142820354026 0.000972582820878813 -1.13727010818888 0.0248299562073108 MirTarget -0.694438299421018 2.71953755807696e-13 NA NA NA hsa-miR-330-5p RGS4 1.15100069700871 4.85551805046014e-07 -1.13727010818888 0.0248299562073108 miRanda -0.585365179531837 2.66675161409552e-08 NA NA NA hsa-miR-421 RGS4 1.17791565395543 6.78526676976629e-06 -1.13727010818888 0.0248299562073108 miRanda -0.386801277640305 3.17551699357506e-05 NA NA NA hsa-miR-486-5p RGS4 -0.194913133034028 0.607377798807705 -1.13727010818888 0.0248299562073108 PITA;miRanda -0.227392497451322 0.000435454037267244 NA NA NA hsa-miR-590-3p RGS4 2.59289455139753 1.03200520972022e-21 -1.13727010818888 0.0248299562073108 mirMAP -0.412768184322862 2.78611605885001e-06 NA NA NA hsa-miR-664a-3p RGS4 0.634721925861133 0.00520070178640421 -1.13727010818888 0.0248299562073108 mirMAP -0.609613042298734 1.2206530201819e-08 NA NA NA hsa-miR-874-3p RGS4 1.95617235160298 2.0152613104032e-12 -1.13727010818888 0.0248299562073108 MirTarget -0.543072640358092 1.31725571833514e-10 NA NA NA hsa-miR-877-5p RGS4 2.94916202082736 1.8151927276044e-13 -1.13727010818888 0.0248299562073108 MirTarget -0.407731542863267 6.20835967123324e-10 NA NA NA hsa-let-7b-5p RHOB 0.604314269683977 0.00140009936153214 -2.20287028501037 2.22821817082748e-20 miRNAWalker2_validate -0.28742738686669 6.82478754125131e-06 NA NA NA hsa-miR-146b-5p RHOB 1.75587235896724 1.15724631266659e-07 -2.20287028501037 2.22821817082748e-20 miRanda -0.12057771336271 0.000778578605831426 NA NA NA hsa-miR-183-5p RHOB 4.19757025992371 4.79612296318304e-26 -2.20287028501037 2.22821817082748e-20 miRNATAP -0.222453684370272 7.22311289613797e-16 NA NA NA hsa-miR-19a-3p RHOB 3.42309334186656 3.02671914353412e-28 -2.20287028501037 2.22821817082748e-20 MirTarget;miRNATAP -0.256775522405486 4.31801365258556e-13 26041879 Ras homolog family member B RHOB was identified as a direct target of miR-19a pancreatic cancer hsa-miR-19b-3p RHOB 2.49529833021187 1.57028265846699e-23 -2.20287028501037 2.22821817082748e-20 MirTarget;miRNATAP -0.320299607820524 8.83819416875341e-13 NA NA NA hsa-miR-21-5p RHOB 2.73773305747971 1.38864982139576e-43 -2.20287028501037 2.22821817082748e-20 miRNAWalker2_validate;miRTarBase;miRNATAP -0.405993059696751 4.47194852880169e-14 21872591;25861727 miR 21 targets the tumor suppressor RhoB and regulates proliferation invasion and apoptosis in colorectal cancer cells; Here we show that expression of miR-21 in HEK293 and several colorectal cancer cells was found inversely correlated with ras homolog gene family member B RhoB expression; miR-21 expression significantly suppressed RhoB 3' UTR luciferase-reporter activity but the inhibitory effect was lost when the putative target sites were mutated; Exogenous miR-21 over-expression mimicked the effect of RhoB knockdown in promoting proliferation and invasion and inhibiting apoptosis whereas anti-miR-21 or RhoB expression yielded opposite effects in colorectal cancer cells; These results suggest that miR-21 is a regulator of RhoB expression and RhoB could be a useful target in exploring the potential therapeutic benefits of miR-21 mediated tumor cell behaviors in colorectal cancer;Here we demonstrate that intravenously-administered chlorotoxin CTX-coupled targeted stable nucleic acid lipid particle SNALP-formulated anti-miR-21 oligonucleotides accumulate preferentially within brain tumors and promote efficient miR-21 silencing which results in increased mRNA and protein levels of its target RhoB while showing no signs of systemic immunogenicity ; colorectal cancer;glioblastoma hsa-miR-224-3p RHOB 1.87536386559317 6.15140969394846e-05 -2.20287028501037 2.22821817082748e-20 mirMAP -0.144948651087247 4.20290547178425e-08 NA NA NA hsa-miR-2355-5p RHOB 1.32510310704724 8.25139516692683e-07 -2.20287028501037 2.22821817082748e-20 MirTarget -0.159026949580805 0.000341561846634387 NA NA NA hsa-miR-32-3p RHOB 2.02436999565685 5.94091197945307e-09 -2.20287028501037 2.22821817082748e-20 MirTarget;miRNATAP -0.102494260221235 0.00851652301062376 NA NA NA hsa-miR-335-5p RHOB 1.77247705492746 2.22457658872091e-06 -2.20287028501037 2.22821817082748e-20 miRNAWalker2_validate -0.121375982322962 0.000131411773989455 NA NA NA hsa-miR-34c-5p RHOB 2.07190852984647 7.35776320806257e-08 -2.20287028501037 2.22821817082748e-20 miRanda -0.148079816613393 6.07981120075184e-06 NA NA NA hsa-miR-362-3p RHOB 2.0756816987665 3.89026064579331e-12 -2.20287028501037 2.22821817082748e-20 miRanda -0.176150262038565 1.35382398235297e-05 NA NA NA hsa-miR-429 RHOB 4.48815175680773 2.44117492218206e-17 -2.20287028501037 2.22821817082748e-20 miRNATAP -0.121154514900883 1.89085729243401e-08 NA NA NA hsa-miR-590-3p RHOB 2.59289455139753 1.03200520972022e-21 -2.20287028501037 2.22821817082748e-20 PITA;miRanda -0.301400648731212 1.5200822347683e-12 NA NA NA hsa-miR-590-5p RHOB 3.18300989862077 2.06813568597893e-26 -2.20287028501037 2.22821817082748e-20 PITA;miRanda;miRNATAP -0.281790567613634 1.08361659338204e-13 NA NA NA hsa-miR-624-5p RHOB 1.47043111118159 8.25080691741182e-09 -2.20287028501037 2.22821817082748e-20 MirTarget -0.203228722598683 2.54371731448243e-05 NA NA NA hsa-miR-629-3p RHOB 2.36570947321815 1.33458201201618e-11 -2.20287028501037 2.22821817082748e-20 mirMAP -0.208753852648202 2.89184440522204e-08 NA NA NA hsa-miR-744-3p RHOB 2.7517405670917 4.22040908411227e-14 -2.20287028501037 2.22821817082748e-20 MirTarget -0.163190341594063 2.81784355298162e-07 NA NA NA hsa-miR-940 RHOB 3.21011374578759 2.7923171128495e-14 -2.20287028501037 2.22821817082748e-20 MirTarget -0.149002159515569 6.56153215892982e-07 NA NA NA hsa-miR-744-5p SAT1 1.48254348878737 3.23019501613577e-09 0.274586296479723 0.259496444748757 miRNAWalker2_validate -0.124345866338534 0.00727057878729088 NA NA NA hsa-miR-30b-3p SCG2 0.834142820354026 0.000972582820878813 0.279692795319293 0.556854690717439 MirTarget -0.385141870965358 2.25561270832948e-05 NA NA NA hsa-miR-98-5p SCG2 1.11154309866014 1.24143909012085e-08 0.279692795319293 0.556854690717439 miRNAWalker2_validate -0.530578148980696 4.96573455423277e-06 NA NA NA hsa-miR-125b-5p SDC1 -1.16462950151259 0.000288900271798384 2.09014789727678 1.29085959790754e-07 mirMAP -0.22046516659249 0.000239133590955091 NA NA NA hsa-miR-338-3p SDC1 0.453166438193782 0.144583389707558 2.09014789727678 1.29085959790754e-07 miRanda -0.184165961439511 0.00330159721221742 NA NA NA hsa-miR-129-5p SERPINE1 -0.524170159980738 0.222582956006346 -0.393407117230654 0.370425399232706 miRanda -0.169701923663541 0.000735839704611328 NA NA NA hsa-miR-148a-5p SERPINE1 1.16173838132242 0.000148929299881612 -0.393407117230654 0.370425399232706 miRNATAP -0.285071111266077 3.2328150503793e-05 NA NA NA hsa-miR-2110 SERPINE1 1.16625590651194 6.4784195289885e-05 -0.393407117230654 0.370425399232706 miRNATAP -0.312861484463966 5.27602364952907e-05 NA NA NA hsa-miR-301a-3p SERPINE1 2.81024345929638 2.29784847962242e-17 -0.393407117230654 0.370425399232706 miRNAWalker2_validate;miRTarBase -0.298339721528262 3.88735440627883e-06 NA NA NA hsa-miR-30b-5p SERPINE1 0.800822374912712 0.000133601914525413 -0.393407117230654 0.370425399232706 MirTarget -0.589742716683692 3.53023994480113e-09 25170877 miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells gastric cancer hsa-miR-30c-5p SERPINE1 0.778774633108 0.000285599212429136 -0.393407117230654 0.370425399232706 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.50652750448866 2.38346715661289e-07 NA NA NA hsa-miR-30d-5p SERPINE1 0.675423997639582 0.00270618816039773 -0.393407117230654 0.370425399232706 miRNATAP -0.643924984116999 3.16202278334948e-12 NA NA NA hsa-miR-378a-5p SERPINE1 0.223456081148306 0.386368843153575 -0.393407117230654 0.370425399232706 MirTarget -0.404559892121807 7.98544569711981e-07 NA NA NA hsa-miR-421 SERPINE1 1.17791565395543 6.78526676976629e-06 -0.393407117230654 0.370425399232706 miRanda -0.395794324632837 7.58532570850472e-07 NA NA NA hsa-miR-425-5p SERPINE1 3.07071373939774 4.02947460586085e-25 -0.393407117230654 0.370425399232706 MirTarget;miRNATAP -0.268582077948886 6.45365175266955e-05 NA NA NA hsa-miR-590-3p SERPINE1 2.59289455139753 1.03200520972022e-21 -0.393407117230654 0.370425399232706 miRanda -0.275014479514724 0.000327361176519488 NA NA NA hsa-miR-769-5p SERPINE1 1.82023760596845 9.6815886564134e-14 -0.393407117230654 0.370425399232706 MirTarget;miRNATAP -0.571996036825274 4.60171798625337e-12 NA NA NA hsa-miR-942-5p SERPINE1 2.35195531153712 5.45059325728841e-16 -0.393407117230654 0.370425399232706 MirTarget -0.197923564863346 0.00510222008258954 NA NA NA hsa-miR-16-5p SERPINE2 1.75824877145857 1.68592440033108e-16 -2.15073073928737 3.47536922631027e-05 miRNAWalker2_validate -0.687399345004424 1.36590724615263e-09 NA NA NA hsa-miR-186-5p SERPINE2 1.47445398888668 3.0781726595413e-15 -2.15073073928737 3.47536922631027e-05 MirTarget -0.926414624727412 7.68851032679134e-13 NA NA NA hsa-miR-30e-3p SERPINE2 -0.215663037684509 0.235375122783546 -2.15073073928737 3.47536922631027e-05 miRNAWalker2_validate -0.809380444222198 6.43957018098648e-09 NA NA NA hsa-miR-335-3p SERPINE2 3.08791651139852 5.31309869723517e-12 -2.15073073928737 3.47536922631027e-05 MirTarget -0.310539400359964 1.06967886832367e-08 NA NA NA hsa-miR-361-5p SERPINE2 0.971859117235239 5.30236555707088e-09 -2.15073073928737 3.47536922631027e-05 miRanda -1.07082672782853 4.90729344530041e-13 NA NA NA hsa-miR-421 SERPINE2 1.17791565395543 6.78526676976629e-06 -2.15073073928737 3.47536922631027e-05 PITA;miRanda -0.343284240277166 0.000361469548667847 NA NA NA hsa-miR-429 SERPINE2 4.48815175680773 2.44117492218206e-17 -2.15073073928737 3.47536922631027e-05 miRanda -0.460577390109698 1.33771774326669e-26 NA NA NA hsa-miR-590-3p SERPINE2 2.59289455139753 1.03200520972022e-21 -2.15073073928737 3.47536922631027e-05 PITA;miRanda;mirMAP -0.369376582655365 5.15891108955325e-05 NA NA NA hsa-miR-29c-3p SERPINH1 -0.00968972577705429 0.97099586346872 0.711142283579022 0.000429483031375957 miRNATAP -0.197051391044183 7.07093746626626e-08 NA NA NA hsa-miR-1301-3p SFRP1 2.54959518791507 5.26618591274892e-18 -4.72165743596444 1.94213340952985e-11 MirTarget -0.929647366224829 2.27335164851971e-17 NA NA NA hsa-miR-144-3p SFRP1 0.658119849508907 0.146943823997989 -4.72165743596444 1.94213340952985e-11 MirTarget;miRNATAP -0.307330683826125 0.000100475665353503 NA NA NA hsa-miR-16-1-3p SFRP1 2.56983217111073 3.02262181237943e-20 -4.72165743596444 1.94213340952985e-11 MirTarget -0.991671709293944 6.59532238581082e-17 NA NA NA hsa-miR-182-5p SFRP1 3.53923166221814 5.07781258121574e-21 -4.72165743596444 1.94213340952985e-11 mirMAP -0.689760445961909 6.52748321080623e-16 NA NA NA hsa-miR-19b-1-5p SFRP1 2.57951428759379 4.31576118703427e-20 -4.72165743596444 1.94213340952985e-11 MirTarget -0.808788841622436 1.27899660304967e-11 NA NA NA hsa-miR-203a-3p SFRP1 3.12352008343999 9.49391438647189e-07 -4.72165743596444 1.94213340952985e-11 MirTarget -0.206110439303078 0.000125185210743585 NA NA NA hsa-miR-26b-3p SFRP1 2.18464160365372 2.11543189388328e-18 -4.72165743596444 1.94213340952985e-11 MirTarget -1.1751124326119 7.4696422523186e-20 NA NA NA hsa-miR-27a-3p SFRP1 1.66542180327138 4.93775737894805e-13 -4.72165743596444 1.94213340952985e-11 MirTarget;miRNATAP -0.517297481926742 0.000463587731630782 NA NA NA hsa-miR-30d-3p SFRP1 0.977747550180601 4.3048212205381e-05 -4.72165743596444 1.94213340952985e-11 miRNATAP -0.812619782319965 1.61238813761418e-08 NA NA NA hsa-miR-328-3p SFRP1 0.596804159297544 0.013858523511843 -4.72165743596444 1.94213340952985e-11 MirTarget -0.806049045586438 1.52940471916615e-08 NA NA NA hsa-miR-33a-3p SFRP1 1.72765312072219 1.51784443453521e-07 -4.72165743596444 1.94213340952985e-11 MirTarget -0.829475588580487 1.30601007666134e-13 NA NA NA hsa-miR-429 SFRP1 4.48815175680773 2.44117492218206e-17 -4.72165743596444 1.94213340952985e-11 miRNATAP -0.527828848274553 3.5454964050295e-18 NA NA NA hsa-miR-484 SFRP1 1.81844463411787 1.82951571230938e-15 -4.72165743596444 1.94213340952985e-11 MirTarget -0.997642924789862 5.9055489271025e-12 NA NA NA hsa-miR-501-5p SFRP1 1.93654809410041 1.3779381780759e-10 -4.72165743596444 1.94213340952985e-11 mirMAP -0.479591960160584 3.64262607664923e-05 NA NA NA hsa-miR-576-5p SFRP1 2.20467023993664 3.4053475193793e-19 -4.72165743596444 1.94213340952985e-11 MirTarget;PITA -0.995471337489543 5.60062584414907e-14 NA NA NA hsa-miR-625-5p SFRP1 1.42540152147292 1.95797147911206e-06 -4.72165743596444 1.94213340952985e-11 MirTarget -0.49096169965567 0.000101372757547789 NA NA NA hsa-miR-7-1-3p SFRP1 1.84950311431067 1.25300363397654e-13 -4.72165743596444 1.94213340952985e-11 MirTarget;mirMAP -0.762107203560682 1.43537728973781e-08 NA NA NA hsa-miR-940 SFRP1 3.21011374578759 2.7923171128495e-14 -4.72165743596444 1.94213340952985e-11 MirTarget -0.686367126934405 4.68712399228061e-16 NA NA NA hsa-miR-96-5p SFRP1 4.89433085814374 1.92000659886961e-31 -4.72165743596444 1.94213340952985e-11 mirMAP -0.669139763083358 1.28798090621278e-18 NA NA NA hsa-miR-129-5p SFRP4 -0.524170159980738 0.222582956006346 -1.41812614850623 0.144139876921528 miRanda -0.637222711825178 6.50533571239219e-09 NA NA NA hsa-miR-135b-5p SFRP4 3.62510365056501 1.09148980810091e-10 -1.41812614850623 0.144139876921528 MirTarget -0.400250647773767 3.11844917971521e-06 NA NA NA hsa-miR-144-5p SFRP4 0.195856574290527 0.61856475838049 -1.41812614850623 0.144139876921528 MirTarget -0.941974526813176 3.50144316140929e-16 NA NA NA hsa-miR-26b-5p SFRP4 0.885393662798425 3.2116297961629e-06 -1.41812614850623 0.144139876921528 miRNAWalker2_validate -1.21337911678089 7.24653678773283e-07 NA NA NA hsa-miR-3607-3p SFRP4 2.68532138541128 5.66716351955047e-14 -1.41812614850623 0.144139876921528 MirTarget -0.849736907270799 3.45388748105254e-11 NA NA NA hsa-miR-375 SFRP4 1.13910305294079 0.0512283522214186 -1.41812614850623 0.144139876921528 miRanda -0.337279266167069 2.30235054354617e-05 NA NA NA hsa-miR-429 SFRP4 4.48815175680773 2.44117492218206e-17 -1.41812614850623 0.144139876921528 miRanda -0.661619050561664 8.57873647657987e-16 NA NA NA hsa-miR-532-5p SFRP4 1.55697650978597 1.57884735535196e-11 -1.41812614850623 0.144139876921528 MirTarget -0.931213634256187 2.56628880190551e-06 NA NA NA hsa-miR-664a-3p SFRP4 0.634721925861133 0.00520070178640421 -1.41812614850623 0.144139876921528 mirMAP -1.03890413731503 4.31949530349031e-07 NA NA NA hsa-miR-944 SFRP4 2.91186649218281 1.31574753528144e-06 -1.41812614850623 0.144139876921528 mirMAP -0.536101827755114 5.07239766557947e-12 NA NA NA hsa-miR-140-5p SGCB 0.844753502512594 3.73722278438606e-05 -1.44760592804974 4.88730706418823e-10 miRanda -0.195223532966665 0.000488045063249711 NA NA NA hsa-miR-16-2-3p SGCB 2.31623086727196 4.29838149388188e-20 -1.44760592804974 4.88730706418823e-10 mirMAP -0.282181982217102 3.91128892781188e-11 NA NA NA hsa-miR-182-5p SGCB 3.53923166221814 5.07781258121574e-21 -1.44760592804974 4.88730706418823e-10 mirMAP -0.327112075589339 2.52618191762848e-34 NA NA NA hsa-miR-192-5p SGCB 2.69002528723195 1.22990188194432e-16 -1.44760592804974 4.88730706418823e-10 miRNAWalker2_validate -0.292935607030071 2.90725777508988e-19 NA NA NA hsa-miR-21-5p SGCB 2.73773305747971 1.38864982139576e-43 -1.44760592804974 4.88730706418823e-10 miRNAWalker2_validate -0.18365578287039 0.000469206423117598 NA NA NA hsa-miR-215-5p SGCB 2.30755467422978 2.38476032118039e-06 -1.44760592804974 4.88730706418823e-10 miRNAWalker2_validate -0.161611483476936 4.33319855702557e-12 NA NA NA hsa-miR-30c-5p SGCB 0.778774633108 0.000285599212429136 -1.44760592804974 4.88730706418823e-10 miRNATAP -0.420911733841911 4.6440373047905e-16 NA NA NA hsa-miR-30d-5p SGCB 0.675423997639582 0.00270618816039773 -1.44760592804974 4.88730706418823e-10 miRNATAP -0.419522175278189 1.70889625673263e-17 NA NA NA hsa-miR-32-3p SGCB 2.02436999565685 5.94091197945307e-09 -1.44760592804974 4.88730706418823e-10 mirMAP -0.224985008573371 6.13099656899567e-10 24348862 microRNA 32 inhibits the proliferation and invasion of the SGC 7901 gastric cancer cell line in vitro gastric cancer hsa-miR-32-5p SGCB 2.34056473219422 6.24134585974322e-20 -1.44760592804974 4.88730706418823e-10 mirMAP -0.365208159152859 8.43046766790926e-19 24348862 microRNA 32 inhibits the proliferation and invasion of the SGC 7901 gastric cancer cell line in vitro gastric cancer hsa-miR-320a SGCB 0.438165828017084 0.0390159073347133 -1.44760592804974 4.88730706418823e-10 miRanda;miRNATAP -0.31302062317078 5.55518687896131e-09 NA NA NA hsa-miR-320b SGCB 1.55692969039548 1.41071034251915e-08 -1.44760592804974 4.88730706418823e-10 miRanda;miRNATAP -0.241733316808248 2.60909142350893e-09 NA NA NA hsa-miR-326 SGCB 0.715313016136042 0.0610265683213359 -1.44760592804974 4.88730706418823e-10 miRanda -0.132883559655909 9.37807300931381e-06 NA NA NA hsa-miR-330-5p SGCB 1.15100069700871 4.85551805046014e-07 -1.44760592804974 4.88730706418823e-10 miRanda -0.300567240747363 8.69828474732489e-10 NA NA NA hsa-miR-335-3p SGCB 3.08791651139852 5.31309869723517e-12 -1.44760592804974 4.88730706418823e-10 mirMAP -0.192382140829353 1.65903488388819e-15 NA NA NA hsa-miR-3607-3p SGCB 2.68532138541128 5.66716351955047e-14 -1.44760592804974 4.88730706418823e-10 miRNATAP -0.227354335390025 3.04520504469073e-13 NA NA NA hsa-miR-374a-5p SGCB 0.484615721953736 0.0042981729815149 -1.44760592804974 4.88730706418823e-10 mirMAP -0.257850778365493 0.000160038755987738 NA NA NA hsa-miR-429 SGCB 4.48815175680773 2.44117492218206e-17 -1.44760592804974 4.88730706418823e-10 miRanda;miRNATAP -0.259630357963112 8.04932932210552e-44 NA NA NA hsa-miR-576-5p SGCB 2.20467023993664 3.4053475193793e-19 -1.44760592804974 4.88730706418823e-10 mirMAP -0.308825856766313 1.63796559189267e-12 NA NA NA hsa-miR-590-3p SGCB 2.59289455139753 1.03200520972022e-21 -1.44760592804974 4.88730706418823e-10 miRNAWalker2_validate;miRanda;mirMAP -0.273858290657238 1.57263412188916e-11 NA NA NA hsa-let-7a-5p SGCD 0.618599506841644 2.76973453058748e-05 -3.54960120603853 1.88168939363754e-09 miRNATAP -1.58867026345106 2.28774505622874e-16 NA NA NA hsa-let-7b-5p SGCD 0.604314269683977 0.00140009936153214 -3.54960120603853 1.88168939363754e-09 miRNATAP -0.916245784709364 2.030513015996e-09 NA NA NA hsa-let-7d-5p SGCD 1.33236798905207 1.1741085658466e-13 -3.54960120603853 1.88168939363754e-09 miRNATAP -1.43649975337679 3.98172889485997e-21 NA NA NA hsa-let-7e-5p SGCD 0.860104282510173 6.04758298373779e-05 -3.54960120603853 1.88168939363754e-09 miRNATAP -0.627058649408415 3.38773219549615e-06 NA NA NA hsa-let-7f-5p SGCD 0.495648727272215 0.00355972741198794 -3.54960120603853 1.88168939363754e-09 miRNATAP -0.863870788715863 5.05883392046704e-07 NA NA NA hsa-let-7g-5p SGCD 1.20061455355116 1.50237505511483e-12 -3.54960120603853 1.88168939363754e-09 miRNATAP -1.74337411079477 6.18428133259661e-28 NA NA NA hsa-miR-103a-3p SGCD 1.44083190496858 1.53799939616416e-13 -3.54960120603853 1.88168939363754e-09 mirMAP -1.69054436459822 2.95828886817886e-36 NA NA NA hsa-miR-106a-5p SGCD 2.48882002962836 1.99757727374521e-12 -3.54960120603853 1.88168939363754e-09 mirMAP -0.710233311073304 1.98394247138796e-20 NA NA NA hsa-miR-106b-5p SGCD 2.46782146831112 1.36171495805632e-23 -3.54960120603853 1.88168939363754e-09 mirMAP -1.27907293290831 3.66344973874455e-35 NA NA NA hsa-miR-107 SGCD 1.30977326593435 1.30372468603965e-11 -3.54960120603853 1.88168939363754e-09 mirMAP -1.36949094306837 3.32973460834789e-22 NA NA NA hsa-miR-125a-3p SGCD 1.24490295132072 5.26925231010328e-06 -3.54960120603853 1.88168939363754e-09 miRanda -0.346414978144765 0.00106707747820612 NA NA NA hsa-miR-129-5p SGCD -0.524170159980738 0.222582956006346 -3.54960120603853 1.88168939363754e-09 miRanda -0.281663802250251 4.27530026702088e-05 NA NA NA hsa-miR-130b-5p SGCD 2.9963110846538 1.98883029416455e-18 -3.54960120603853 1.88168939363754e-09 mirMAP -0.777407852890205 2.04244514886812e-22 NA NA NA hsa-miR-144-5p SGCD 0.195856574290527 0.61856475838049 -3.54960120603853 1.88168939363754e-09 mirMAP -0.483316065776932 2.83074342780821e-11 NA NA NA hsa-miR-148a-5p SGCD 1.16173838132242 0.000148929299881612 -3.54960120603853 1.88168939363754e-09 mirMAP -0.394852077864315 2.76521917361849e-05 NA NA NA hsa-miR-148b-5p SGCD 2.18024067300781 2.84770452413262e-14 -3.54960120603853 1.88168939363754e-09 mirMAP -1.04996449795677 1.16779167295751e-26 NA NA NA hsa-miR-15a-5p SGCD 2.34669284378787 1.69544424500258e-23 -3.54960120603853 1.88168939363754e-09 miRNATAP -1.29662939667327 2.00098881800273e-32 NA NA NA hsa-miR-15b-5p SGCD 1.57112623124278 9.14247846750597e-13 -3.54960120603853 1.88168939363754e-09 miRNATAP -1.42587620205563 2.14128468950082e-32 NA NA NA hsa-miR-16-2-3p SGCD 2.31623086727196 4.29838149388188e-20 -3.54960120603853 1.88168939363754e-09 mirMAP -1.09291571256444 1.21927822192283e-25 NA NA NA hsa-miR-16-5p SGCD 1.75824877145857 1.68592440033108e-16 -3.54960120603853 1.88168939363754e-09 miRNATAP -1.50712407276898 5.50145817215433e-35 NA NA NA hsa-miR-17-5p SGCD 3.2710598467455 9.93128340539455e-27 -3.54960120603853 1.88168939363754e-09 mirMAP -0.958070095382767 1.61014803877904e-30 NA NA NA hsa-miR-19a-3p SGCD 3.42309334186656 3.02671914353412e-28 -3.54960120603853 1.88168939363754e-09 mirMAP -0.795232551992328 2.13536699514649e-21 NA NA NA hsa-miR-19b-3p SGCD 2.49529833021187 1.57028265846699e-23 -3.54960120603853 1.88168939363754e-09 mirMAP -1.10590838973618 3.46746665031995e-26 NA NA NA hsa-miR-200b-3p SGCD 3.78235093249346 3.18343003239465e-14 -3.54960120603853 1.88168939363754e-09 mirMAP -0.537773654886332 1.10796907479944e-23 NA NA NA hsa-miR-200c-3p SGCD 3.50132673580082 2.42716349086937e-15 -3.54960120603853 1.88168939363754e-09 mirMAP -0.674570017915175 5.40649659440121e-30 NA NA NA hsa-miR-20a-5p SGCD 3.15577933619191 4.19753346442454e-25 -3.54960120603853 1.88168939363754e-09 mirMAP -0.951193016198133 1.33203754798674e-29 NA NA NA hsa-miR-20b-5p SGCD 2.07706563022469 1.10107236083433e-05 -3.54960120603853 1.88168939363754e-09 mirMAP -0.46392916985265 4.30087532532139e-15 NA NA NA hsa-miR-21-3p SGCD 2.19296355304364 4.63665722759779e-15 -3.54960120603853 1.88168939363754e-09 mirMAP -0.422819910963583 2.54939404085201e-05 NA NA NA hsa-miR-23a-3p SGCD 1.00493340843378 2.55313889288924e-08 -3.54960120603853 1.88168939363754e-09 mirMAP -0.795813546629722 6.08744336328557e-07 NA NA NA hsa-miR-25-3p SGCD 1.36472605225697 4.83790725935681e-11 -3.54960120603853 1.88168939363754e-09 mirMAP -1.10515375091209 1.36101444747077e-16 NA NA NA hsa-miR-26b-5p SGCD 0.885393662798425 3.2116297961629e-06 -3.54960120603853 1.88168939363754e-09 miRNATAP -1.0888934827314 3.2335531035272e-13 NA NA NA hsa-miR-29b-1-5p SGCD 1.55384379072167 4.76870585070176e-05 -3.54960120603853 1.88168939363754e-09 mirMAP -0.319558344868878 6.40774317507891e-05 NA NA NA hsa-miR-30d-3p SGCD 0.977747550180601 4.3048212205381e-05 -3.54960120603853 1.88168939363754e-09 mirMAP -1.11955839914912 4.7251308038442e-22 NA NA NA hsa-miR-30e-3p SGCD -0.215663037684509 0.235375122783546 -3.54960120603853 1.88168939363754e-09 mirMAP -1.16443724917088 2.00731654759783e-13 NA NA NA hsa-miR-32-3p SGCD 2.02436999565685 5.94091197945307e-09 -3.54960120603853 1.88168939363754e-09 mirMAP -0.777501596597782 8.27001112650503e-18 NA NA NA hsa-miR-32-5p SGCD 2.34056473219422 6.24134585974322e-20 -3.54960120603853 1.88168939363754e-09 mirMAP -0.863274706121562 2.64558121208183e-16 NA NA NA hsa-miR-331-5p SGCD 2.17414714166315 1.54547681391888e-18 -3.54960120603853 1.88168939363754e-09 mirMAP -1.10758376230003 1.17105923801484e-23 NA NA NA hsa-miR-335-3p SGCD 3.08791651139852 5.31309869723517e-12 -3.54960120603853 1.88168939363754e-09 mirMAP -0.304931890802415 1.19004558850704e-06 NA NA NA hsa-miR-335-5p SGCD 1.77247705492746 2.22457658872091e-06 -3.54960120603853 1.88168939363754e-09 miRNAWalker2_validate;miRNATAP -0.315546324262358 3.73548536684092e-05 NA NA NA hsa-miR-339-5p SGCD 2.68710938429893 3.03134080808154e-16 -3.54960120603853 1.88168939363754e-09 PITA;miRNATAP -0.589234907250395 1.65528518785891e-12 NA NA NA hsa-miR-33a-3p SGCD 1.72765312072219 1.51784443453521e-07 -3.54960120603853 1.88168939363754e-09 mirMAP -0.914564950481427 1.04987923952564e-23 NA NA NA hsa-miR-33a-5p SGCD 3.79671563098419 1.15966309820345e-18 -3.54960120603853 1.88168939363754e-09 mirMAP;miRNATAP -0.648300430124514 4.97728061726287e-22 NA NA NA hsa-miR-3607-3p SGCD 2.68532138541128 5.66716351955047e-14 -3.54960120603853 1.88168939363754e-09 mirMAP -0.683353226303833 2.15089655917554e-18 NA NA NA hsa-miR-361-5p SGCD 0.971859117235239 5.30236555707088e-09 -3.54960120603853 1.88168939363754e-09 miRNATAP -1.68844934716746 1.77735550326034e-24 NA NA NA hsa-miR-362-3p SGCD 2.0756816987665 3.89026064579331e-12 -3.54960120603853 1.88168939363754e-09 miRNATAP -0.328951929194497 0.000807050617055338 NA NA NA hsa-miR-363-3p SGCD 1.50575300026701 0.00020976164678918 -3.54960120603853 1.88168939363754e-09 mirMAP -0.459919768964141 4.67076638189335e-11 NA NA NA hsa-miR-374a-3p SGCD 0.533309330504947 0.00192918429705142 -3.54960120603853 1.88168939363754e-09 mirMAP;miRNATAP -0.732933924311224 1.71624620022157e-05 NA NA NA hsa-miR-429 SGCD 4.48815175680773 2.44117492218206e-17 -3.54960120603853 1.88168939363754e-09 mirMAP -0.493371856968715 7.03387301366327e-23 NA NA NA hsa-miR-486-5p SGCD -0.194913133034028 0.607377798807705 -3.54960120603853 1.88168939363754e-09 miRanda -0.415771985878606 4.42025720185551e-08 NA NA NA hsa-miR-500a-5p SGCD 1.72110365584658 3.0807246212659e-10 -3.54960120603853 1.88168939363754e-09 mirMAP -0.395959839597004 0.00015021871917643 NA NA NA hsa-miR-532-5p SGCD 1.55697650978597 1.57884735535196e-11 -3.54960120603853 1.88168939363754e-09 PITA -0.864194354948959 8.53477589313979e-13 NA NA NA hsa-miR-576-5p SGCD 2.20467023993664 3.4053475193793e-19 -3.54960120603853 1.88168939363754e-09 mirMAP -0.986282073697537 1.458533787519e-19 NA NA NA hsa-miR-582-3p SGCD 0.00876844181512659 0.977126166214707 -3.54960120603853 1.88168939363754e-09 mirMAP -0.536763159727292 1.2639007244931e-08 NA NA NA hsa-miR-589-3p SGCD 2.51971841868825 2.39125940264107e-11 -3.54960120603853 1.88168939363754e-09 mirMAP -0.594801641226324 1.30693622915442e-12 NA NA NA hsa-miR-590-3p SGCD 2.59289455139753 1.03200520972022e-21 -3.54960120603853 1.88168939363754e-09 PITA;miRanda;mirMAP;miRNATAP -0.836846828294165 2.09390615301775e-16 NA NA NA hsa-miR-590-5p SGCD 3.18300989862077 2.06813568597893e-26 -3.54960120603853 1.88168939363754e-09 miRanda -0.84525217769993 4.93057857755783e-21 NA NA NA hsa-miR-625-3p SGCD 1.18769734290812 2.47200238827911e-06 -3.54960120603853 1.88168939363754e-09 mirMAP -0.690465390511423 9.67304208574105e-10 NA NA NA hsa-miR-628-5p SGCD 0.799263053510813 2.28892357418044e-05 -3.54960120603853 1.88168939363754e-09 miRNATAP -0.495649740337226 0.00138371646703188 NA NA NA hsa-miR-664a-3p SGCD 0.634721925861133 0.00520070178640421 -3.54960120603853 1.88168939363754e-09 mirMAP -0.947909269172404 3.75421068369128e-14 NA NA NA hsa-miR-7-1-3p SGCD 1.84950311431067 1.25300363397654e-13 -3.54960120603853 1.88168939363754e-09 mirMAP -0.915551413662213 7.9310598446094e-17 NA NA NA hsa-miR-9-5p SGCD 1.02304182473283 0.042901377604859 -3.54960120603853 1.88168939363754e-09 mirMAP;miRNATAP -0.174084969656638 0.0024648830838418 NA NA NA hsa-miR-92a-3p SGCD 2.06460102658973 1.44784291084757e-19 -3.54960120603853 1.88168939363754e-09 mirMAP -1.40643384547565 1.28650488213498e-35 NA NA NA hsa-miR-93-5p SGCD 3.03961860136032 1.11672209617395e-24 -3.54960120603853 1.88168939363754e-09 mirMAP -1.07871298297635 8.93991457865351e-37 NA NA NA hsa-miR-944 SGCD 2.91186649218281 1.31574753528144e-06 -3.54960120603853 1.88168939363754e-09 PITA;mirMAP;miRNATAP -0.407623990060444 9.0052765504743e-18 NA NA NA hsa-miR-421 SGCG 1.17791565395543 6.78526676976629e-06 -5.20259599300482 3.74272268685113e-24 miRanda -0.350557171697372 0.000450103300843451 NA NA NA hsa-miR-590-3p SGCG 2.59289455139753 1.03200520972022e-21 -5.20259599300482 3.74272268685113e-24 miRanda -0.61121282869007 5.51546394414151e-11 NA NA NA hsa-miR-590-5p SGCG 3.18300989862077 2.06813568597893e-26 -5.20259599300482 3.74272268685113e-24 miRanda -0.581799427659715 2.26581926081495e-12 NA NA NA hsa-miR-342-3p SLC6A8 1.49115144672245 1.43879249744621e-07 0.51063151487315 0.193761016983222 miRanda -0.274319310724746 3.12394894556685e-05 NA NA NA hsa-miR-126-5p SLIT2 0.895338176458417 2.33372756450713e-05 -4.35684615406749 1.00973475835035e-11 mirMAP -0.402760624769557 0.00734261574371412 NA NA NA hsa-miR-200b-3p SLIT2 3.78235093249346 3.18343003239465e-14 -4.35684615406749 1.00973475835035e-11 TargetScan -0.61736353356801 1.93520179598927e-26 NA NA NA hsa-miR-26b-3p SLIT2 2.18464160365372 2.11543189388328e-18 -4.35684615406749 1.00973475835035e-11 miRNATAP -1.22145471361213 3.51180821919971e-26 NA NA NA hsa-miR-3065-5p SLIT2 2.74629919868982 1.86846589298284e-08 -4.35684615406749 1.00973475835035e-11 mirMAP -0.385840555971234 6.7094391881418e-07 NA NA NA hsa-miR-330-3p SLIT2 0.876747334239085 0.00073709016089703 -4.35684615406749 1.00973475835035e-11 miRNAWalker2_validate -0.866233530456682 3.52033806196176e-13 NA NA NA hsa-miR-576-5p SLIT2 2.20467023993664 3.4053475193793e-19 -4.35684615406749 1.00973475835035e-11 mirMAP -1.01509481254303 1.97800048956757e-17 NA NA NA hsa-miR-590-3p SLIT2 2.59289455139753 1.03200520972022e-21 -4.35684615406749 1.00973475835035e-11 miRanda -0.82679001148387 1.44979499828903e-13 NA NA NA hsa-miR-664a-3p SLIT2 0.634721925861133 0.00520070178640421 -4.35684615406749 1.00973475835035e-11 mirMAP -0.790414070959039 1.1483880002539e-08 NA NA NA hsa-miR-125a-3p SLIT3 1.24490295132072 5.26925231010328e-06 -3.59991978393086 7.98217561727376e-15 miRanda -0.267946549477597 0.00146682978197192 NA NA NA hsa-miR-130b-3p SLIT3 3.5350292994509 1.73934183852569e-27 -3.59991978393086 7.98217561727376e-15 mirMAP -0.478234053406528 1.84887947045294e-13 NA NA NA hsa-miR-130b-5p SLIT3 2.9963110846538 1.98883029416455e-18 -3.59991978393086 7.98217561727376e-15 mirMAP -0.413635256799653 2.75685541000204e-10 NA NA NA hsa-miR-135b-5p SLIT3 3.62510365056501 1.09148980810091e-10 -3.59991978393086 7.98217561727376e-15 mirMAP -0.259214569232682 6.54665243078e-10 NA NA NA hsa-miR-148a-5p SLIT3 1.16173838132242 0.000148929299881612 -3.59991978393086 7.98217561727376e-15 MirTarget;miRNATAP -0.260206654386579 0.000536347644918008 NA NA NA hsa-miR-148b-5p SLIT3 2.18024067300781 2.84770452413262e-14 -3.59991978393086 7.98217561727376e-15 mirMAP -0.544715230887528 2.10041957809141e-11 NA NA NA hsa-miR-16-2-3p SLIT3 2.31623086727196 4.29838149388188e-20 -3.59991978393086 7.98217561727376e-15 mirMAP -0.957124034403602 1.19328894637159e-31 NA NA NA hsa-miR-188-5p SLIT3 2.52825126596644 6.78099435999778e-14 -3.59991978393086 7.98217561727376e-15 mirMAP -0.471901921458983 1.13628103387304e-11 NA NA NA hsa-miR-192-5p SLIT3 2.69002528723195 1.22990188194432e-16 -3.59991978393086 7.98217561727376e-15 mirMAP -0.399865124992792 3.5083353887228e-09 NA NA NA hsa-miR-1976 SLIT3 2.06550563678192 7.81396978619772e-18 -3.59991978393086 7.98217561727376e-15 mirMAP -0.751129763605338 6.41596161620216e-17 NA NA NA hsa-miR-200c-5p SLIT3 2.95761105443819 3.11105707262802e-11 -3.59991978393086 7.98217561727376e-15 mirMAP -0.36271486907671 6.61876177978684e-12 NA NA NA hsa-miR-224-3p SLIT3 1.87536386559317 6.15140969394846e-05 -3.59991978393086 7.98217561727376e-15 mirMAP -0.235766203455779 3.83706386373195e-06 NA NA NA hsa-miR-26b-5p SLIT3 0.885393662798425 3.2116297961629e-06 -3.59991978393086 7.98217561727376e-15 mirMAP -0.559052898923141 3.91774712525688e-06 NA NA NA hsa-miR-301a-3p SLIT3 2.81024345929638 2.29784847962242e-17 -3.59991978393086 7.98217561727376e-15 mirMAP -0.488561456875598 1.97363557494847e-12 NA NA NA hsa-miR-330-5p SLIT3 1.15100069700871 4.85551805046014e-07 -3.59991978393086 7.98217561727376e-15 miRanda;mirMAP -0.444499555127356 8.86704054964126e-06 NA NA NA hsa-miR-33a-3p SLIT3 1.72765312072219 1.51784443453521e-07 -3.59991978393086 7.98217561727376e-15 mirMAP -0.285723686349287 0.000177349397917373 NA NA NA hsa-miR-362-3p SLIT3 2.0756816987665 3.89026064579331e-12 -3.59991978393086 7.98217561727376e-15 miRanda -0.525827926592761 6.08893179969567e-12 NA NA NA hsa-miR-362-5p SLIT3 1.59303749908759 9.582675908797e-08 -3.59991978393086 7.98217561727376e-15 TargetScan -0.323540238115362 2.1834097242789e-05 NA NA NA hsa-miR-374b-3p SLIT3 0.930487774873495 2.74420094310516e-05 -3.59991978393086 7.98217561727376e-15 mirMAP -0.320226937635004 0.00222586667078323 NA NA NA hsa-miR-429 SLIT3 4.48815175680773 2.44117492218206e-17 -3.59991978393086 7.98217561727376e-15 miRNATAP -0.162387206689757 0.00010185386860644 NA NA NA hsa-miR-454-3p SLIT3 2.47234127820054 1.12878018736016e-21 -3.59991978393086 7.98217561727376e-15 mirMAP -0.676902032172625 1.88466674315819e-15 NA NA NA hsa-miR-500a-5p SLIT3 1.72110365584658 3.0807246212659e-10 -3.59991978393086 7.98217561727376e-15 mirMAP -0.496469606652358 1.40709664471792e-09 NA NA NA hsa-miR-550a-3p SLIT3 1.78308792532884 2.47673569057582e-07 -3.59991978393086 7.98217561727376e-15 mirMAP -0.599640591259048 1.37615749161213e-16 NA NA NA hsa-miR-589-3p SLIT3 2.51971841868825 2.39125940264107e-11 -3.59991978393086 7.98217561727376e-15 mirMAP -0.527681028258751 1.54296944583849e-15 NA NA NA hsa-miR-590-3p SLIT3 2.59289455139753 1.03200520972022e-21 -3.59991978393086 7.98217561727376e-15 miRanda;mirMAP -0.818506602424457 4.92649889490357e-25 NA NA NA hsa-miR-590-5p SLIT3 3.18300989862077 2.06813568597893e-26 -3.59991978393086 7.98217561727376e-15 miRanda -0.67979616494785 1.6009955849415e-21 NA NA NA hsa-miR-625-5p SLIT3 1.42540152147292 1.95797147911206e-06 -3.59991978393086 7.98217561727376e-15 mirMAP -0.554315709499731 1.7676782576709e-11 NA NA NA hsa-miR-9-5p SLIT3 1.02304182473283 0.042901377604859 -3.59991978393086 7.98217561727376e-15 mirMAP -0.142842942540801 0.00178041756926288 NA NA NA hsa-miR-940 SLIT3 3.21011374578759 2.7923171128495e-14 -3.59991978393086 7.98217561727376e-15 MirTarget -0.270569737924495 2.65011466729203e-06 NA NA NA hsa-miR-96-5p SLIT3 4.89433085814374 1.92000659886961e-31 -3.59991978393086 7.98217561727376e-15 TargetScan -0.36595463294683 9.37313144067578e-13 NA NA NA hsa-miR-99b-3p SLIT3 1.62436885280973 8.09988670773273e-10 -3.59991978393086 7.98217561727376e-15 mirMAP -0.235865277975179 0.00627048938509291 NA NA NA hsa-miR-107 SNAI2 1.30977326593435 1.30372468603965e-11 -0.280307189347724 0.489884936104145 miRanda -0.587951478655937 2.23241515205897e-09 NA NA NA hsa-miR-148b-3p SNAI2 1.97815018171325 6.07715327281595e-26 -0.280307189347724 0.489884936104145 miRNAWalker2_validate -0.5115588617257 1.85198661011602e-07 NA NA NA hsa-miR-182-5p SNAI2 3.53923166221814 5.07781258121574e-21 -0.280307189347724 0.489884936104145 miRNAWalker2_validate;miRNATAP -0.226684880391696 4.11330558077327e-06 NA NA NA hsa-miR-200b-3p SNAI2 3.78235093249346 3.18343003239465e-14 -0.280307189347724 0.489884936104145 TargetScan -0.267184160966678 5.83468454644939e-13 NA NA NA hsa-miR-200c-3p SNAI2 3.50132673580082 2.42716349086937e-15 -0.280307189347724 0.489884936104145 miRNATAP -0.183480437180395 1.58844201912264e-05 NA NA NA hsa-miR-330-3p SNAI2 0.876747334239085 0.00073709016089703 -0.280307189347724 0.489884936104145 PITA -0.244344141932354 0.00118305093009477 NA NA NA hsa-miR-335-3p SNAI2 3.08791651139852 5.31309869723517e-12 -0.280307189347724 0.489884936104145 mirMAP -0.125422480922013 0.00324023238716861 NA NA NA hsa-miR-33a-3p SNAI2 1.72765312072219 1.51784443453521e-07 -0.280307189347724 0.489884936104145 MirTarget -0.326770909713066 3.29484348166007e-07 NA NA NA hsa-miR-375 SNAI2 1.13910305294079 0.0512283522214186 -0.280307189347724 0.489884936104145 miRanda -0.160294717693396 1.3349557949902e-06 NA NA NA hsa-miR-421 SNAI2 1.17791565395543 6.78526676976629e-06 -0.280307189347724 0.489884936104145 miRanda -0.277190656175256 0.000195037380670986 NA NA NA hsa-miR-429 SNAI2 4.48815175680773 2.44117492218206e-17 -0.280307189347724 0.489884936104145 PITA;miRanda;miRNATAP -0.243690996915046 1.98440445952138e-12 NA NA NA hsa-miR-532-5p SNAI2 1.55697650978597 1.57884735535196e-11 -0.280307189347724 0.489884936104145 PITA -0.570320787851888 2.40819282921953e-12 NA NA NA hsa-miR-96-5p SNAI2 4.89433085814374 1.92000659886961e-31 -0.280307189347724 0.489884936104145 miRNATAP -0.21174388168592 1.54578985770895e-06 NA NA NA hsa-miR-16-1-3p SNTB1 2.56983217111073 3.02262181237943e-20 -0.911805744058188 0.00568879022431995 MirTarget;mirMAP -0.17436740554976 0.00196786635741353 NA NA NA hsa-miR-16-2-3p SNTB1 2.31623086727196 4.29838149388188e-20 -0.911805744058188 0.00568879022431995 mirMAP -0.169593986463159 0.00524792197961064 NA NA NA hsa-miR-24-3p SNTB1 0.99989036772428 1.35595013650376e-07 -0.911805744058188 0.00568879022431995 miRNAWalker2_validate -0.392407630296954 2.53138789280169e-06 NA NA NA hsa-miR-26b-3p SNTB1 2.18464160365372 2.11543189388328e-18 -0.911805744058188 0.00568879022431995 MirTarget -0.203737513178804 0.000936428187309315 NA NA NA hsa-miR-361-5p SNTB1 0.971859117235239 5.30236555707088e-09 -0.911805744058188 0.00568879022431995 miRanda -0.248210150676419 0.00971958116742113 NA NA NA hsa-miR-576-5p SNTB1 2.20467023993664 3.4053475193793e-19 -0.911805744058188 0.00568879022431995 mirMAP -0.171340412469146 0.00607207407248329 NA NA NA hsa-miR-664a-3p SNTB1 0.634721925861133 0.00520070178640421 -0.911805744058188 0.00568879022431995 MirTarget -0.220094438752767 0.00183445159044411 NA NA NA hsa-miR-10a-5p SPARC 1.15016989191194 0.00372037233992369 -0.39075637198812 0.230766766661185 miRNAWalker2_validate -0.23808285279329 9.41952246387464e-10 NA NA NA hsa-miR-192-5p SPARC 2.69002528723195 1.22990188194432e-16 -0.39075637198812 0.230766766661185 miRNAWalker2_validate -0.342987435951913 4.29583062258943e-14 NA NA NA hsa-miR-19a-3p SPARC 3.42309334186656 3.02671914353412e-28 -0.39075637198812 0.230766766661185 mirMAP -0.309240779284942 2.82756586590176e-11 NA NA NA hsa-miR-203a-3p SPARC 3.12352008343999 9.49391438647189e-07 -0.39075637198812 0.230766766661185 MirTarget -0.121003565214904 5.18925900945414e-07 NA NA NA hsa-miR-224-3p SPARC 1.87536386559317 6.15140969394846e-05 -0.39075637198812 0.230766766661185 mirMAP -0.196432775909508 1.18495095577718e-08 NA NA NA hsa-miR-29b-3p SPARC 1.65828197923813 1.02676780888141e-09 -0.39075637198812 0.230766766661185 miRNATAP -0.266896021914367 2.39341701525212e-06 NA NA NA hsa-miR-29c-3p SPARC -0.00968972577705429 0.97099586346872 -0.39075637198812 0.230766766661185 miRNAWalker2_validate;miRTarBase;miRNATAP -0.364297118712571 4.41043987301914e-10 NA NA NA hsa-miR-3065-5p SPARC 2.74629919868982 1.86846589298284e-08 -0.39075637198812 0.230766766661185 mirMAP -0.151106116285111 9.47339198499308e-05 NA NA NA hsa-miR-335-3p SPARC 3.08791651139852 5.31309869723517e-12 -0.39075637198812 0.230766766661185 MirTarget -0.102704386313801 0.00268976777866346 NA NA NA hsa-miR-345-5p SPARC 3.63532310411307 2.2698112107996e-21 -0.39075637198812 0.230766766661185 MirTarget -0.284929943436735 6.66856271819268e-14 NA NA NA hsa-miR-361-5p SPARC 0.971859117235239 5.30236555707088e-09 -0.39075637198812 0.230766766661185 MirTarget -0.77653356883867 1.41448505314038e-17 NA NA NA hsa-miR-374a-3p SPARC 0.533309330504947 0.00192918429705142 -0.39075637198812 0.230766766661185 MirTarget -0.251145879473215 0.00677481782103383 NA NA NA hsa-miR-421 SPARC 1.17791565395543 6.78526676976629e-06 -0.39075637198812 0.230766766661185 miRanda -0.339325699709882 9.45858539618906e-09 NA NA NA hsa-miR-532-3p SPARC 1.96631878320218 4.53421954361695e-13 -0.39075637198812 0.230766766661185 miRNATAP -0.360797789253584 7.52093187662145e-11 NA NA NA hsa-miR-589-3p SPARC 2.51971841868825 2.39125940264107e-11 -0.39075637198812 0.230766766661185 MirTarget -0.216574985226456 2.5911964402121e-06 NA NA NA hsa-miR-592 SPARC 1.51765968871077 0.000636335248013204 -0.39075637198812 0.230766766661185 MirTarget -0.145204826622821 4.88691466027565e-05 NA NA NA hsa-miR-625-5p SPARC 1.42540152147292 1.95797147911206e-06 -0.39075637198812 0.230766766661185 MirTarget -0.263947880516945 3.36639284818501e-06 NA NA NA hsa-miR-7-1-3p SPARC 1.84950311431067 1.25300363397654e-13 -0.39075637198812 0.230766766661185 mirMAP -0.350126811352465 7.76697199280378e-09 NA NA NA hsa-let-7a-3p SPOCK1 1.42015538786275 7.03375209382654e-13 -0.605188458396325 0.230666218148078 mirMAP -0.44281564640927 0.000246749755424345 NA NA NA hsa-miR-126-5p SPOCK1 0.895338176458417 2.33372756450713e-05 -0.605188458396325 0.230666218148078 mirMAP -0.497983249462218 1.38958450843802e-05 NA NA NA hsa-miR-129-5p SPOCK1 -0.524170159980738 0.222582956006346 -0.605188458396325 0.230666218148078 MirTarget;miRanda -0.23228139428368 5.59388420584509e-05 NA NA NA hsa-miR-130b-3p SPOCK1 3.5350292994509 1.73934183852569e-27 -0.605188458396325 0.230666218148078 MirTarget -0.3544719587646 3.44878531920471e-07 NA NA NA hsa-miR-140-5p SPOCK1 0.844753502512594 3.73722278438606e-05 -0.605188458396325 0.230666218148078 MirTarget;PITA;miRanda -0.342693149712005 0.0040714048847833 NA NA NA hsa-miR-148a-5p SPOCK1 1.16173838132242 0.000148929299881612 -0.605188458396325 0.230666218148078 mirMAP -0.251628152036652 0.00149011903361946 NA NA NA hsa-miR-16-1-3p SPOCK1 2.56983217111073 3.02262181237943e-20 -0.605188458396325 0.230666218148078 MirTarget -0.409898906625222 1.54712347576215e-06 NA NA NA hsa-miR-193a-5p SPOCK1 0.562511612963676 0.0239254699649222 -0.605188458396325 0.230666218148078 TargetScan -0.26735384458981 0.00659836358784174 NA NA NA hsa-miR-19a-3p SPOCK1 3.42309334186656 3.02671914353412e-28 -0.605188458396325 0.230666218148078 MirTarget -0.42109229821938 6.09617792585592e-09 NA NA NA hsa-miR-19b-3p SPOCK1 2.49529833021187 1.57028265846699e-23 -0.605188458396325 0.230666218148078 MirTarget -0.565459612177273 5.78334356931411e-10 NA NA NA hsa-miR-2110 SPOCK1 1.16625590651194 6.4784195289885e-05 -0.605188458396325 0.230666218148078 MirTarget -0.499926640744025 1.42893191178586e-08 NA NA NA hsa-miR-224-3p SPOCK1 1.87536386559317 6.15140969394846e-05 -0.605188458396325 0.230666218148078 mirMAP -0.228414283764092 2.20065965742118e-05 NA NA NA hsa-miR-23a-5p SPOCK1 1.46491071577368 0.000241866585858992 -0.605188458396325 0.230666218148078 MirTarget -0.248279419967742 0.000117236550926417 NA NA NA hsa-miR-26b-5p SPOCK1 0.885393662798425 3.2116297961629e-06 -0.605188458396325 0.230666218148078 mirMAP -0.346576663960589 0.00702311045379132 NA NA NA hsa-miR-301a-3p SPOCK1 2.81024345929638 2.29784847962242e-17 -0.605188458396325 0.230666218148078 MirTarget -0.482129243345703 4.97161595513191e-11 NA NA NA hsa-miR-3065-5p SPOCK1 2.74629919868982 1.86846589298284e-08 -0.605188458396325 0.230666218148078 MirTarget;miRNATAP -0.23782878632573 7.27264257599719e-05 NA NA NA hsa-miR-30d-3p SPOCK1 0.977747550180601 4.3048212205381e-05 -0.605188458396325 0.230666218148078 mirMAP -0.507091056677829 5.14448389987094e-07 NA NA NA hsa-miR-30e-3p SPOCK1 -0.215663037684509 0.235375122783546 -0.605188458396325 0.230666218148078 mirMAP -0.738777837150801 3.98858495129596e-08 NA NA NA hsa-miR-326 SPOCK1 0.715313016136042 0.0610265683213359 -0.605188458396325 0.230666218148078 MirTarget;miRanda -0.19357086680277 0.00255164663180026 NA NA NA hsa-miR-330-5p SPOCK1 1.15100069700871 4.85551805046014e-07 -0.605188458396325 0.230666218148078 MirTarget;miRanda -0.493875749282906 2.6549822669212e-06 NA NA NA hsa-miR-33a-3p SPOCK1 1.72765312072219 1.51784443453521e-07 -0.605188458396325 0.230666218148078 mirMAP -0.551618933187867 2.23091722904676e-12 NA NA NA hsa-miR-375 SPOCK1 1.13910305294079 0.0512283522214186 -0.605188458396325 0.230666218148078 miRNATAP -0.178398068166854 1.62778145921497e-05 NA NA NA hsa-miR-429 SPOCK1 4.48815175680773 2.44117492218206e-17 -0.605188458396325 0.230666218148078 miRNATAP -0.236555705606663 5.85877177752123e-08 NA NA NA hsa-miR-452-5p SPOCK1 1.37180058737183 0.00171494843537772 -0.605188458396325 0.230666218148078 mirMAP -0.180696769677592 0.00111017417566968 NA NA NA hsa-miR-454-3p SPOCK1 2.47234127820054 1.12878018736016e-21 -0.605188458396325 0.230666218148078 MirTarget -0.559928937094563 7.52214960471617e-10 NA NA NA hsa-miR-501-3p SPOCK1 1.83132758513743 1.10971547702065e-10 -0.605188458396325 0.230666218148078 PITA;TargetScan;miRNATAP -0.462663386772243 2.66271175601285e-08 NA NA NA hsa-miR-502-3p SPOCK1 1.50560877085049 1.2647489756373e-11 -0.605188458396325 0.230666218148078 PITA;miRNATAP -0.624311494289462 4.13985181217922e-09 NA NA NA hsa-miR-590-3p SPOCK1 2.59289455139753 1.03200520972022e-21 -0.605188458396325 0.230666218148078 PITA;miRanda;mirMAP -0.537759681629869 5.62302741058365e-10 NA NA NA hsa-miR-590-5p SPOCK1 3.18300989862077 2.06813568597893e-26 -0.605188458396325 0.230666218148078 MirTarget;miRanda;mirMAP -0.494351910567824 1.60572277832906e-10 NA NA NA hsa-miR-625-5p SPOCK1 1.42540152147292 1.95797147911206e-06 -0.605188458396325 0.230666218148078 MirTarget -0.382723004960216 1.40841686122694e-05 NA NA NA hsa-miR-629-3p SPOCK1 2.36570947321815 1.33458201201618e-11 -0.605188458396325 0.230666218148078 MirTarget -0.319074118443923 3.1563694371576e-05 NA NA NA hsa-miR-671-5p SPOCK1 2.97733652243246 1.21148452344738e-23 -0.605188458396325 0.230666218148078 MirTarget;PITA -0.462724117312443 1.18317007757706e-08 NA NA NA hsa-miR-769-5p SPOCK1 1.82023760596845 9.6815886564134e-14 -0.605188458396325 0.230666218148078 PITA -0.657645992674172 4.66895218870287e-12 NA NA NA hsa-miR-139-5p SPP1 -1.52606598644743 1.20474151350665e-08 3.18422829338263 7.71504146360324e-09 miRanda -0.39124385273467 8.62801906059466e-05 NA NA NA hsa-miR-128-3p TAGLN 1.63756041666078 6.79626586407187e-14 -3.46298850799896 6.29460245115941e-13 miRNAWalker2_validate -1.16685978858663 8.04860595133039e-32 NA NA NA hsa-miR-129-5p TAGLN -0.524170159980738 0.222582956006346 -3.46298850799896 6.29460245115941e-13 miRanda -0.299696545149544 9.65895397383095e-08 NA NA NA hsa-miR-26b-5p TAGLN 0.885393662798425 3.2116297961629e-06 -3.46298850799896 6.29460245115941e-13 miRNAWalker2_validate -0.932812198167964 2.69078052447479e-14 NA NA NA hsa-miR-34c-5p TAGLN 2.07190852984647 7.35776320806257e-08 -3.46298850799896 6.29460245115941e-13 miRanda -0.210880629534454 0.00125255738922606 NA NA NA hsa-miR-625-5p TAGLN 1.42540152147292 1.95797147911206e-06 -3.46298850799896 6.29460245115941e-13 mirMAP -0.622557506061614 2.0810299854556e-13 NA NA NA hsa-miR-7-5p TAGLN 2.28980165299999 1.5131097560452e-07 -3.46298850799896 6.29460245115941e-13 miRNAWalker2_validate -0.334549791121782 5.79125554321716e-09 NA NA NA hsa-miR-9-5p TAGLN 1.02304182473283 0.042901377604859 -3.46298850799896 6.29460245115941e-13 miRNAWalker2_validate -0.20292795026611 1.58024362840662e-05 NA NA NA hsa-miR-940 TAGLN 3.21011374578759 2.7923171128495e-14 -3.46298850799896 6.29460245115941e-13 MirTarget;PITA;miRNATAP -0.647292753834983 4.35409744614743e-31 NA NA NA hsa-miR-106b-5p TFPI2 2.46782146831112 1.36171495805632e-23 -1.28502417428214 0.0588551593267528 miRNATAP -0.579425643020574 4.2027257399164e-06 NA NA NA hsa-miR-20a-5p TFPI2 3.15577933619191 4.19753346442454e-25 -1.28502417428214 0.0588551593267528 miRNATAP -0.267770963784028 0.00863234133476377 NA NA NA hsa-miR-23b-3p TFPI2 -0.251132426825047 0.150200321210792 -1.28502417428214 0.0588551593267528 MirTarget;miRNATAP -0.694339768840867 0.000279802407446743 NA NA NA hsa-miR-664a-3p TFPI2 0.634721925861133 0.00520070178640421 -1.28502417428214 0.0588551593267528 mirMAP -0.739747965953843 2.80370601321554e-07 NA NA NA hsa-miR-944 TFPI2 2.91186649218281 1.31574753528144e-06 -1.28502417428214 0.0588551593267528 mirMAP -0.160933786449221 0.0038675363621659 NA NA NA hsa-miR-744-5p TGFB1 1.48254348878737 3.23019501613577e-09 -0.000200257511168367 0.999409206375481 miRNAWalker2_validate;miRNATAP -0.229419410482444 6.9384219754003e-06 NA NA NA hsa-miR-16-5p TGFBI 1.75824877145857 1.68592440033108e-16 -0.0589395905113266 0.898815506618176 miRNAWalker2_validate -0.36400887583027 0.000340224658240638 NA NA NA hsa-miR-26b-5p TGFBI 0.885393662798425 3.2116297961629e-06 -0.0589395905113266 0.898815506618176 miRNAWalker2_validate -0.39238115903412 0.000852741318695135 NA NA NA hsa-miR-429 TGFBI 4.48815175680773 2.44117492218206e-17 -0.0589395905113266 0.898815506618176 miRanda -0.415860574461824 6.64564302718085e-28 NA NA NA hsa-miR-590-5p TGFBI 3.18300989862077 2.06813568597893e-26 -0.0589395905113266 0.898815506618176 PITA;miRanda;miRNATAP -0.238304402176616 0.000958963798763218 NA NA NA hsa-miR-9-5p TGFBI 1.02304182473283 0.042901377604859 -0.0589395905113266 0.898815506618176 miRNAWalker2_validate;miRTarBase -0.135024829065682 0.00222673585117986 NA NA NA hsa-let-7b-5p TGFBR3 0.604314269683977 0.00140009936153214 -2.59061685335061 7.44943414202018e-11 MirTarget -0.353571778463802 0.000737905769843802 NA NA NA hsa-let-7i-5p TGFBR3 0.412877696970403 0.00622731051981756 -2.59061685335061 7.44943414202018e-11 MirTarget -0.694609854826207 1.28284665233358e-07 NA NA NA hsa-miR-15a-5p TGFBR3 2.34669284378787 1.69544424500258e-23 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.334666618812116 2.4364757552723e-05 NA NA NA hsa-miR-15b-5p TGFBR3 1.57112623124278 9.14247846750597e-13 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.358067034321255 4.08959861418962e-05 NA NA NA hsa-miR-16-2-3p TGFBR3 2.31623086727196 4.29838149388188e-20 -2.59061685335061 7.44943414202018e-11 mirMAP -0.544752570527393 6.96637221131045e-14 NA NA NA hsa-miR-16-5p TGFBR3 1.75824877145857 1.68592440033108e-16 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.535995055796637 1.19037291949918e-09 NA NA NA hsa-miR-181a-5p TGFBR3 2.29556023480783 1.8138457900616e-21 -2.59061685335061 7.44943414202018e-11 miRNAWalker2_validate;mirMAP;miRNATAP -0.533327553140963 2.53974355292015e-12 NA NA NA hsa-miR-181b-5p TGFBR3 2.49307679431293 3.92829250217627e-20 -2.59061685335061 7.44943414202018e-11 mirMAP -0.432103104420789 2.3616864237891e-10 NA NA NA hsa-miR-185-3p TGFBR3 2.3922478518806 1.3373426768452e-14 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.178532534746358 0.0036751676836322 NA NA NA hsa-miR-186-5p TGFBR3 1.47445398888668 3.0781726595413e-15 -2.59061685335061 7.44943414202018e-11 MirTarget -0.432866677091555 2.38094635988513e-05 NA NA NA hsa-miR-18a-3p TGFBR3 2.14813400940323 2.23460809936028e-06 -2.59061685335061 7.44943414202018e-11 MirTarget -0.384745830428724 3.20279500560706e-13 NA NA NA hsa-miR-18a-5p TGFBR3 3.78535678765353 3.72446596213886e-26 -2.59061685335061 7.44943414202018e-11 MirTarget -0.408782150301723 1.32531260268041e-14 NA NA NA hsa-miR-193a-3p TGFBR3 1.60460546928078 2.86169793322984e-07 -2.59061685335061 7.44943414202018e-11 MirTarget;miRanda;miRNATAP -0.404117628316179 3.34660410567723e-11 NA NA NA hsa-miR-193b-3p TGFBR3 2.25711804611899 4.1940744806631e-14 -2.59061685335061 7.44943414202018e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.54263409776695 1.06348017136205e-18 NA NA NA hsa-miR-21-5p TGFBR3 2.73773305747971 1.38864982139576e-43 -2.59061685335061 7.44943414202018e-11 miRNAWalker2_validate -0.873696976080408 1.42070935389156e-24 NA NA NA hsa-miR-222-5p TGFBR3 1.25632771414778 0.000138653440511922 -2.59061685335061 7.44943414202018e-11 MirTarget -0.637586491113155 8.70674708946357e-31 NA NA NA hsa-miR-223-3p TGFBR3 0.390350910791999 0.345956164976892 -2.59061685335061 7.44943414202018e-11 MirTarget -0.357942230234306 8.65290396410165e-15 NA NA NA hsa-miR-23a-3p TGFBR3 1.00493340843378 2.55313889288924e-08 -2.59061685335061 7.44943414202018e-11 MirTarget;mirMAP -0.922565153945025 1.07662734633214e-18 NA NA NA hsa-miR-27a-3p TGFBR3 1.66542180327138 4.93775737894805e-13 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.856547795782396 8.50152722903816e-28 NA NA NA hsa-miR-29a-5p TGFBR3 1.46749674755271 3.34605004270294e-07 -2.59061685335061 7.44943414202018e-11 mirMAP -0.680050674340825 1.4093844780056e-23 NA NA NA hsa-miR-338-3p TGFBR3 0.453166438193782 0.144583389707558 -2.59061685335061 7.44943414202018e-11 miRanda -0.32591907256696 2.15757294303162e-07 NA NA NA hsa-miR-339-5p TGFBR3 2.68710938429893 3.03134080808154e-16 -2.59061685335061 7.44943414202018e-11 miRanda -0.261061195001236 5.31993152374657e-06 NA NA NA hsa-miR-340-5p TGFBR3 0.30282999308409 0.157744789519131 -2.59061685335061 7.44943414202018e-11 mirMAP -0.300070644061892 0.00119354677245125 NA NA NA hsa-miR-34c-5p TGFBR3 2.07190852984647 7.35776320806257e-08 -2.59061685335061 7.44943414202018e-11 miRanda;miRNATAP -0.277892023741616 1.74141696542429e-07 NA NA NA hsa-miR-3607-3p TGFBR3 2.68532138541128 5.66716351955047e-14 -2.59061685335061 7.44943414202018e-11 mirMAP -0.209035995525523 0.000133096015392737 NA NA NA hsa-miR-361-3p TGFBR3 1.07367425434318 1.73142774168958e-09 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.605594317686423 2.29492169573009e-08 NA NA NA hsa-miR-409-3p TGFBR3 0.877551657794358 0.00171210686733898 -2.59061685335061 7.44943414202018e-11 mirMAP -0.19586487016773 0.00536284050179962 NA NA NA hsa-miR-424-5p TGFBR3 1.61930224569578 1.89642549274994e-10 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.453498113768427 1.3903796591463e-09 NA NA NA hsa-miR-455-5p TGFBR3 2.2582442061694 1.43472128037398e-13 -2.59061685335061 7.44943414202018e-11 miRanda -0.595169359534449 1.29501226263914e-23 NA NA NA hsa-miR-484 TGFBR3 1.81844463411787 1.82951571230938e-15 -2.59061685335061 7.44943414202018e-11 MirTarget;miRNATAP -0.285353013064365 0.000636411287742009 NA NA NA hsa-miR-589-3p TGFBR3 2.51971841868825 2.39125940264107e-11 -2.59061685335061 7.44943414202018e-11 MirTarget -0.350435514214757 8.24412223410027e-10 NA NA NA hsa-miR-590-3p TGFBR3 2.59289455139753 1.03200520972022e-21 -2.59061685335061 7.44943414202018e-11 MirTarget;miRanda;mirMAP -0.471663498128764 1.30242745091055e-11 NA NA NA hsa-miR-590-5p TGFBR3 3.18300989862077 2.06813568597893e-26 -2.59061685335061 7.44943414202018e-11 miRanda -0.399800495757582 1.45902129417123e-10 NA NA NA hsa-miR-625-5p TGFBR3 1.42540152147292 1.95797147911206e-06 -2.59061685335061 7.44943414202018e-11 MirTarget -0.303726876266838 1.96419820901604e-05 NA NA NA hsa-miR-627-5p TGFBR3 1.91115607258341 1.92839519618473e-09 -2.59061685335061 7.44943414202018e-11 MirTarget -0.302068567741635 1.24234557528916e-05 NA NA NA hsa-miR-7-1-3p TGFBR3 1.84950311431067 1.25300363397654e-13 -2.59061685335061 7.44943414202018e-11 mirMAP -0.481191222243271 1.84156222707957e-10 NA NA NA hsa-miR-106a-5p TGM2 2.48882002962836 1.99757727374521e-12 -1.14690935857596 0.0144751654848477 MirTarget -0.445206110194064 2.71333481227038e-13 NA NA NA hsa-miR-106b-5p TGM2 2.46782146831112 1.36171495805632e-23 -1.14690935857596 0.0144751654848477 MirTarget -0.968148869398104 7.46587638894677e-33 NA NA NA hsa-miR-129-5p TGM2 -0.524170159980738 0.222582956006346 -1.14690935857596 0.0144751654848477 miRanda;mirMAP -0.327180257312775 6.74049006467797e-10 NA NA NA hsa-miR-17-5p TGM2 3.2710598467455 9.93128340539455e-27 -1.14690935857596 0.0144751654848477 MirTarget -0.558008749157835 1.32288703615511e-16 NA NA NA hsa-miR-20a-5p TGM2 3.15577933619191 4.19753346442454e-25 -1.14690935857596 0.0144751654848477 MirTarget -0.546551158202488 9.73911599133667e-16 NA NA NA hsa-miR-20b-5p TGM2 2.07706563022469 1.10107236083433e-05 -1.14690935857596 0.0144751654848477 MirTarget -0.332086998714767 8.14662406587688e-13 NA NA NA hsa-miR-28-5p TGM2 0.230152919654905 0.0742909586754846 -1.14690935857596 0.0144751654848477 miRanda -0.640159119578279 0.00042404334773368 NA NA NA hsa-miR-30b-3p TGM2 0.834142820354026 0.000972582820878813 -1.14690935857596 0.0144751654848477 mirMAP -0.697836165726288 1.48940635304058e-15 NA NA NA hsa-miR-320a TGM2 0.438165828017084 0.0390159073347133 -1.14690935857596 0.0144751654848477 miRanda -0.870367064213392 6.38466189257848e-17 NA NA NA hsa-miR-320b TGM2 1.55692969039548 1.41071034251915e-08 -1.14690935857596 0.0144751654848477 miRanda -0.641177353863037 4.74083922253005e-16 NA NA NA hsa-miR-324-3p TGM2 2.08739139768981 3.11885987067952e-13 -1.14690935857596 0.0144751654848477 MirTarget -0.777783844756601 1.02348959963082e-26 NA NA NA hsa-miR-330-5p TGM2 1.15100069700871 4.85551805046014e-07 -1.14690935857596 0.0144751654848477 miRanda -0.457832286861801 2.96711925932586e-06 NA NA NA hsa-miR-339-5p TGM2 2.68710938429893 3.03134080808154e-16 -1.14690935857596 0.0144751654848477 miRanda -0.318697869753715 1.42506167941749e-06 NA NA NA hsa-miR-34a-5p TGM2 1.9016323452565 1.43092834643601e-14 -1.14690935857596 0.0144751654848477 miRNAWalker2_validate -0.596492455291748 9.16055361131472e-12 NA NA NA hsa-miR-375 TGM2 1.13910305294079 0.0512283522214186 -1.14690935857596 0.0144751654848477 miRNAWalker2_validate -0.145727264597735 0.000162738183157484 NA NA NA hsa-miR-590-3p TGM2 2.59289455139753 1.03200520972022e-21 -1.14690935857596 0.0144751654848477 miRanda -0.458984070431771 1.50705297359735e-08 NA NA NA hsa-miR-93-5p TGM2 3.03961860136032 1.11672209617395e-24 -1.14690935857596 0.0144751654848477 MirTarget -0.769408367703368 4.77864548312463e-30 NA NA NA hsa-let-7a-3p THBS1 1.42015538786275 7.03375209382654e-13 -2.1277814514878 2.63898598170147e-08 mirMAP -0.324256229204835 0.000499512291196202 NA NA NA hsa-let-7a-5p THBS1 0.618599506841644 2.76973453058748e-05 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate;TargetScan -0.793931296421232 4.01263206453322e-10 NA NA NA hsa-let-7b-5p THBS1 0.604314269683977 0.00140009936153214 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.3783572455659 0.00015103278303974 NA NA NA hsa-let-7d-5p THBS1 1.33236798905207 1.1741085658466e-13 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.859220357114439 4.03379037942602e-18 NA NA NA hsa-miR-151a-3p THBS1 1.24018761527407 1.08839919675408e-07 -2.1277814514878 2.63898598170147e-08 MirTarget -0.694569328638858 1.06745479684608e-19 NA NA NA hsa-miR-16-1-3p THBS1 2.56983217111073 3.02262181237943e-20 -2.1277814514878 2.63898598170147e-08 MirTarget -0.547933930739432 9.0287268587793e-18 NA NA NA hsa-miR-17-5p THBS1 3.2710598467455 9.93128340539455e-27 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.535410262786805 2.01390645555519e-22 NA NA NA hsa-miR-181a-5p THBS1 2.29556023480783 1.8138457900616e-21 -2.1277814514878 2.63898598170147e-08 mirMAP -0.311799903081761 2.56428301535389e-05 NA NA NA hsa-miR-181b-5p THBS1 2.49307679431293 3.92829250217627e-20 -2.1277814514878 2.63898598170147e-08 mirMAP -0.286545329851077 1.38651496488125e-05 NA NA NA hsa-miR-181c-5p THBS1 1.58587920618301 1.57506918816933e-10 -2.1277814514878 2.63898598170147e-08 mirMAP -0.509013456937225 2.75401083927959e-12 NA NA NA hsa-miR-182-5p THBS1 3.53923166221814 5.07781258121574e-21 -2.1277814514878 2.63898598170147e-08 MirTarget -0.464276709680251 4.8914160255443e-25 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 1.47445398888668 3.0781726595413e-15 -2.1277814514878 2.63898598170147e-08 mirMAP -0.790631830268256 8.0462867743067e-17 NA NA NA hsa-miR-18a-5p THBS1 3.78535678765353 3.72446596213886e-26 -2.1277814514878 2.63898598170147e-08 MirTarget -0.35804586565731 2.12561579001182e-12 NA NA NA hsa-miR-19a-3p THBS1 3.42309334186656 3.02671914353412e-28 -2.1277814514878 2.63898598170147e-08 MirTarget;mirMAP -0.479011511951586 1.31597383903182e-18 NA NA NA hsa-miR-19b-3p THBS1 2.49529833021187 1.57028265846699e-23 -2.1277814514878 2.63898598170147e-08 MirTarget;mirMAP -0.632469943962746 2.39270341905539e-20 NA NA NA hsa-miR-200a-5p THBS1 3.86316681673704 1.81076942093171e-15 -2.1277814514878 2.63898598170147e-08 MirTarget -0.396991686050601 3.54394977146249e-30 NA NA NA hsa-miR-200b-5p THBS1 2.54484902707822 1.59240467582976e-06 -2.1277814514878 2.63898598170147e-08 MirTarget -0.404286942819477 1.05447906162297e-27 NA NA NA hsa-miR-20a-5p THBS1 3.15577933619191 4.19753346442454e-25 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.555674406219999 6.63212782868049e-24 NA NA NA hsa-miR-3065-5p THBS1 2.74629919868982 1.86846589298284e-08 -2.1277814514878 2.63898598170147e-08 MirTarget -0.272591193657042 2.35925406869001e-09 NA NA NA hsa-miR-32-5p THBS1 2.34056473219422 6.24134585974322e-20 -2.1277814514878 2.63898598170147e-08 mirMAP -0.532149898174492 6.38170990221277e-15 NA NA NA hsa-miR-335-3p THBS1 3.08791651139852 5.31309869723517e-12 -2.1277814514878 2.63898598170147e-08 mirMAP -0.184976537215221 5.11650202408596e-06 NA NA NA hsa-miR-33a-3p THBS1 1.72765312072219 1.51784443453521e-07 -2.1277814514878 2.63898598170147e-08 MirTarget;mirMAP -0.543323514403514 5.49591905485477e-20 NA NA NA hsa-miR-375 THBS1 1.13910305294079 0.0512283522214186 -2.1277814514878 2.63898598170147e-08 miRanda -0.150506420398144 2.2392975982835e-06 NA NA NA hsa-miR-421 THBS1 1.17791565395543 6.78526676976629e-06 -2.1277814514878 2.63898598170147e-08 miRanda -0.423737249967144 1.77998923967034e-09 NA NA NA hsa-miR-491-5p THBS1 0.615770352820862 0.0418295628761654 -2.1277814514878 2.63898598170147e-08 miRanda -0.325347677729002 8.67284344402748e-07 NA NA NA hsa-miR-500a-5p THBS1 1.72110365584658 3.0807246212659e-10 -2.1277814514878 2.63898598170147e-08 mirMAP -0.230571146840421 0.000634888611580494 NA NA NA hsa-miR-576-5p THBS1 2.20467023993664 3.4053475193793e-19 -2.1277814514878 2.63898598170147e-08 mirMAP -0.534982297177329 6.59187971715022e-14 NA NA NA hsa-miR-589-3p THBS1 2.51971841868825 2.39125940264107e-11 -2.1277814514878 2.63898598170147e-08 mirMAP -0.296840513596274 5.92807281377074e-08 NA NA NA hsa-miR-590-3p THBS1 2.59289455139753 1.03200520972022e-21 -2.1277814514878 2.63898598170147e-08 miRanda -0.503581788401113 2.48033554789491e-14 NA NA NA hsa-miR-590-5p THBS1 3.18300989862077 2.06813568597893e-26 -2.1277814514878 2.63898598170147e-08 miRanda;mirMAP -0.527120722441568 1.25825852850212e-19 NA NA NA hsa-miR-629-3p THBS1 2.36570947321815 1.33458201201618e-11 -2.1277814514878 2.63898598170147e-08 MirTarget -0.227068483079105 0.000123952249921696 NA NA NA hsa-miR-664a-3p THBS1 0.634721925861133 0.00520070178640421 -2.1277814514878 2.63898598170147e-08 mirMAP -0.570820389169422 2.01213211719281e-12 NA NA NA hsa-miR-671-5p THBS1 2.97733652243246 1.21148452344738e-23 -2.1277814514878 2.63898598170147e-08 MirTarget -0.50692748391382 1.23943837944331e-16 NA NA NA hsa-miR-7-1-3p THBS1 1.84950311431067 1.25300363397654e-13 -2.1277814514878 2.63898598170147e-08 MirTarget;mirMAP -0.527473744629066 1.61947893119384e-13 NA NA NA hsa-miR-92a-3p THBS1 2.06460102658973 1.44784291084757e-19 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.769477829682195 9.27438286986465e-25 NA NA NA hsa-miR-940 THBS1 3.21011374578759 2.7923171128495e-14 -2.1277814514878 2.63898598170147e-08 MirTarget -0.39529960019763 2.55260567750224e-18 NA NA NA hsa-miR-944 THBS1 2.91186649218281 1.31574753528144e-06 -2.1277814514878 2.63898598170147e-08 MirTarget;PITA -0.199538618837297 1.63491480056503e-10 NA NA NA hsa-miR-98-5p THBS1 1.11154309866014 1.24143909012085e-08 -2.1277814514878 2.63898598170147e-08 miRNAWalker2_validate -0.724389356283188 5.99048052515149e-15 NA NA NA hsa-miR-106a-5p THBS2 2.48882002962836 1.99757727374521e-12 -0.819009338080235 0.127001426128545 MirTarget -0.45330116032702 9.62830193644936e-11 NA NA NA hsa-miR-106b-5p THBS2 2.46782146831112 1.36171495805632e-23 -0.819009338080235 0.127001426128545 MirTarget -0.72193483715216 1.20112772084899e-13 NA NA NA hsa-miR-16-2-3p THBS2 2.31623086727196 4.29838149388188e-20 -0.819009338080235 0.127001426128545 mirMAP -0.579127576562822 2.3897295143244e-09 NA NA NA hsa-miR-17-5p THBS2 3.2710598467455 9.93128340539455e-27 -0.819009338080235 0.127001426128545 MirTarget;TargetScan -0.513157286321094 5.2287894266298e-11 NA NA NA hsa-miR-182-5p THBS2 3.53923166221814 5.07781258121574e-21 -0.819009338080235 0.127001426128545 MirTarget;miRNATAP -0.378179542663928 4.95986922868172e-09 NA NA NA hsa-miR-20a-5p THBS2 3.15577933619191 4.19753346442454e-25 -0.819009338080235 0.127001426128545 MirTarget -0.524692617570923 2.5011034764088e-11 NA NA NA hsa-miR-20b-5p THBS2 2.07706563022469 1.10107236083433e-05 -0.819009338080235 0.127001426128545 MirTarget -0.34463233280832 9.76692709595905e-11 NA NA NA hsa-miR-32-3p THBS2 2.02436999565685 5.94091197945307e-09 -0.819009338080235 0.127001426128545 miRNATAP -0.439958956826284 1.04187343353676e-07 NA NA NA hsa-miR-320a THBS2 0.438165828017084 0.0390159073347133 -0.819009338080235 0.127001426128545 mirMAP -0.738913348853994 1.08030683289646e-09 NA NA NA hsa-miR-320b THBS2 1.55692969039548 1.41071034251915e-08 -0.819009338080235 0.127001426128545 mirMAP -0.576382788700426 3.09497468053932e-10 NA NA NA hsa-miR-582-3p THBS2 0.00876844181512659 0.977126166214707 -0.819009338080235 0.127001426128545 miRNATAP -0.362802196964235 1.83546472971205e-05 NA NA NA hsa-miR-590-3p THBS2 2.59289455139753 1.03200520972022e-21 -0.819009338080235 0.127001426128545 miRanda;mirMAP -0.415992971199857 8.15429265241593e-06 NA NA NA hsa-miR-590-5p THBS2 3.18300989862077 2.06813568597893e-26 -0.819009338080235 0.127001426128545 miRanda -0.373930357407742 7.01724345875243e-06 NA NA NA hsa-miR-598-3p THBS2 0.760968346755936 0.027870939187342 -0.819009338080235 0.127001426128545 MirTarget -0.585284197674181 6.99576512493496e-16 NA NA NA hsa-miR-7-1-3p THBS2 1.84950311431067 1.25300363397654e-13 -0.819009338080235 0.127001426128545 MirTarget;mirMAP -0.465723609777495 3.68568678198485e-06 NA NA NA hsa-miR-9-5p THBS2 1.02304182473283 0.042901377604859 -0.819009338080235 0.127001426128545 miRNATAP -0.139117281625275 0.00664593677825042 NA NA NA hsa-miR-93-5p THBS2 3.03961860136032 1.11672209617395e-24 -0.819009338080235 0.127001426128545 MirTarget -0.631952471595904 3.23254182973957e-15 NA NA NA hsa-miR-96-5p THBS2 4.89433085814374 1.92000659886961e-31 -0.819009338080235 0.127001426128545 TargetScan;miRNATAP -0.333472922491884 8.9160648870827e-09 NA NA NA hsa-miR-185-3p THY1 2.3922478518806 1.3373426768452e-14 0.31862122424845 0.36192587842108 MirTarget -0.192497242967046 0.000247431494518024 NA NA NA hsa-miR-24-3p THY1 0.99989036772428 1.35595013650376e-07 0.31862122424845 0.36192587842108 mirMAP -0.260278157598607 0.0033573197945427 NA NA NA hsa-miR-330-3p THY1 0.876747334239085 0.00073709016089703 0.31862122424845 0.36192587842108 mirMAP -0.386750072195107 1.40784477792551e-09 NA NA NA hsa-miR-423-5p THY1 0.963563145758616 9.86109015204915e-07 0.31862122424845 0.36192587842108 MirTarget -0.59360738676815 1.18476171286421e-12 NA NA NA hsa-miR-744-5p THY1 1.48254348878737 3.23019501613577e-09 0.31862122424845 0.36192587842108 MirTarget -0.400587695234456 8.74000417137914e-10 NA NA NA hsa-miR-940 THY1 3.21011374578759 2.7923171128495e-14 0.31862122424845 0.36192587842108 MirTarget -0.240882721684684 7.45079992682671e-09 NA NA NA hsa-miR-361-5p TIMP1 0.971859117235239 5.30236555707088e-09 0.12550229776307 0.68520057972656 miRanda -0.490482818676097 2.94512631888387e-08 NA NA NA hsa-let-7a-3p TIMP3 1.42015538786275 7.03375209382654e-13 -1.51021603240101 2.67590650148561e-05 mirMAP;miRNATAP -0.441284656566871 3.05636837848315e-07 NA NA NA hsa-let-7f-1-3p TIMP3 1.55054488387679 7.31326775537952e-11 -1.51021603240101 2.67590650148561e-05 mirMAP -0.257414296853406 0.000540367885060719 NA NA NA hsa-miR-101-3p TIMP3 0.522819989585461 0.00375627731618038 -1.51021603240101 2.67590650148561e-05 miRNATAP -0.315683926473334 0.0013029329475152 NA NA NA hsa-miR-103a-3p TIMP3 1.44083190496858 1.53799939616416e-13 -1.51021603240101 2.67590650148561e-05 miRNAWalker2_validate;miRTarBase -0.633051129677573 1.64379614893899e-13 22783422 miR-103 inhibitor transfection increased the activity of the luciferase reporter assay containing the TIMP-3 3'-untranslated region UTR construct and increased the levels of the TIMP-3 protein but not its mRNA in endometrial cancer cell lines; Our data suggested that miR-103 post-transcriptionally downregulates the expression of the tumor suppressor TIMP-3 and stimulates growth and invasion in endometrial cancer cell lines endometrial cancer hsa-miR-106a-5p TIMP3 2.48882002962836 1.99757727374521e-12 -1.51021603240101 2.67590650148561e-05 miRNATAP -0.355463736964527 3.51559475554685e-14 NA NA NA hsa-miR-106b-5p TIMP3 2.46782146831112 1.36171495805632e-23 -1.51021603240101 2.67590650148561e-05 miRNATAP -0.614405121422876 1.51446602745146e-21 NA NA NA hsa-miR-144-3p TIMP3 0.658119849508907 0.146943823997989 -1.51021603240101 2.67590650148561e-05 miRNATAP -0.181188883800486 4.72182904158198e-06 NA NA NA hsa-miR-148a-5p TIMP3 1.16173838132242 0.000148929299881612 -1.51021603240101 2.67590650148561e-05 mirMAP -0.225299230711765 7.19218007773531e-05 NA NA NA hsa-miR-16-1-3p TIMP3 2.56983217111073 3.02262181237943e-20 -1.51021603240101 2.67590650148561e-05 mirMAP -0.30579831848738 5.97366684067947e-07 NA NA NA hsa-miR-16-5p TIMP3 1.75824877145857 1.68592440033108e-16 -1.51021603240101 2.67590650148561e-05 miRNAWalker2_validate -0.592654985138064 2.11388355625899e-14 NA NA NA hsa-miR-181a-5p TIMP3 2.29556023480783 1.8138457900616e-21 -1.51021603240101 2.67590650148561e-05 MirTarget;miRNATAP -0.194366895081438 0.00517589282566951 NA NA NA hsa-miR-181b-5p TIMP3 2.49307679431293 3.92829250217627e-20 -1.51021603240101 2.67590650148561e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.195862347157758 0.00153815053001219 27383203 Moreover miR-181b was found to directly target the 3' untranslated region 3'UTR of Timp3 mRNA affecting TGF-β-induced EMT gastric cancer hsa-miR-181c-5p TIMP3 1.58587920618301 1.57506918816933e-10 -1.51021603240101 2.67590650148561e-05 MirTarget;miRNATAP -0.25798308024884 0.000199267447467404 NA NA NA hsa-miR-181d-5p TIMP3 1.52204912185579 9.2693319057748e-08 -1.51021603240101 2.67590650148561e-05 MirTarget -0.191231832956286 0.00166882003492984 NA NA NA hsa-miR-188-5p TIMP3 2.52825126596644 6.78099435999778e-14 -1.51021603240101 2.67590650148561e-05 mirMAP -0.340509148226662 1.0755702211371e-10 NA NA NA hsa-miR-20a-5p TIMP3 3.15577933619191 4.19753346442454e-25 -1.51021603240101 2.67590650148561e-05 miRNATAP -0.440456223667381 3.9094444476144e-17 NA NA NA hsa-miR-3065-5p TIMP3 2.74629919868982 1.86846589298284e-08 -1.51021603240101 2.67590650148561e-05 MirTarget;miRNATAP -0.216158193084921 4.54451743928302e-07 NA NA NA hsa-miR-30c-5p TIMP3 0.778774633108 0.000285599212429136 -1.51021603240101 2.67590650148561e-05 miRNATAP -0.32217734707299 7.84411106961955e-05 NA NA NA hsa-miR-30d-5p TIMP3 0.675423997639582 0.00270618816039773 -1.51021603240101 2.67590650148561e-05 miRNATAP -0.314264054391365 5.39699510213332e-05 NA NA NA hsa-miR-32-3p TIMP3 2.02436999565685 5.94091197945307e-09 -1.51021603240101 2.67590650148561e-05 mirMAP;miRNATAP -0.429017003594686 5.16174846807809e-15 NA NA NA hsa-miR-3200-3p TIMP3 2.70510522077868 1.90469509928484e-08 -1.51021603240101 2.67590650148561e-05 mirMAP -0.269652419476799 3.53782104586107e-13 NA NA NA hsa-miR-330-3p TIMP3 0.876747334239085 0.00073709016089703 -1.51021603240101 2.67590650148561e-05 mirMAP -0.265839102790036 7.64612192846515e-05 NA NA NA hsa-miR-3607-3p TIMP3 2.68532138541128 5.66716351955047e-14 -1.51021603240101 2.67590650148561e-05 MirTarget;miRNATAP -0.198596930253694 4.50854805891193e-05 NA NA NA hsa-miR-362-3p TIMP3 2.0756816987665 3.89026064579331e-12 -1.51021603240101 2.67590650148561e-05 miRanda -0.335501210385315 8.88487191384355e-09 NA NA NA hsa-miR-423-5p TIMP3 0.963563145758616 9.86109015204915e-07 -1.51021603240101 2.67590650148561e-05 miRNAWalker2_validate -0.566417507022634 8.38686078275663e-11 NA NA NA hsa-miR-452-3p TIMP3 2.42521958420768 4.08754552781156e-07 -1.51021603240101 2.67590650148561e-05 MirTarget -0.112915101104342 0.00183181397311779 NA NA NA hsa-miR-491-5p TIMP3 0.615770352820862 0.0418295628761654 -1.51021603240101 2.67590650148561e-05 miRanda -0.313978128513413 3.5080328884886e-07 NA NA NA hsa-miR-505-3p TIMP3 1.45322244209148 8.86597629645867e-10 -1.51021603240101 2.67590650148561e-05 mirMAP -0.613167909949202 2.17950725965295e-18 NA NA NA hsa-miR-589-3p TIMP3 2.51971841868825 2.39125940264107e-11 -1.51021603240101 2.67590650148561e-05 mirMAP -0.317301310818088 4.21389045293802e-10 NA NA NA hsa-miR-590-3p TIMP3 2.59289455139753 1.03200520972022e-21 -1.51021603240101 2.67590650148561e-05 PITA;miRanda;miRNATAP -0.477398455321802 8.85520272719108e-15 NA NA NA hsa-miR-590-5p TIMP3 3.18300989862077 2.06813568597893e-26 -1.51021603240101 2.67590650148561e-05 MirTarget;PITA;miRanda;miRNATAP -0.398512637521771 5.26352473834923e-13 NA NA NA hsa-miR-660-5p TIMP3 1.82692095272076 1.92040083607196e-13 -1.51021603240101 2.67590650148561e-05 miRNATAP -0.369912001280004 5.41827903595955e-08 NA NA NA hsa-miR-7-1-3p TIMP3 1.84950311431067 1.25300363397654e-13 -1.51021603240101 2.67590650148561e-05 mirMAP -0.532776312064189 9.49532452942291e-16 NA NA NA hsa-miR-126-5p TNC 0.895338176458417 2.33372756450713e-05 -1.22885204293992 0.0251580253603685 miRNATAP -0.357984093331907 0.00438147708100397 NA NA NA hsa-miR-330-3p TNC 0.876747334239085 0.00073709016089703 -1.22885204293992 0.0251580253603685 MirTarget -0.822718297482533 7.76964944968044e-17 NA NA NA hsa-miR-330-5p TNC 1.15100069700871 4.85551805046014e-07 -1.22885204293992 0.0251580253603685 MirTarget;miRanda;miRNATAP -0.570830378295863 6.0234172906234e-07 NA NA NA hsa-miR-335-5p TNC 1.77247705492746 2.22457658872091e-06 -1.22885204293992 0.0251580253603685 miRNAWalker2_validate;miRTarBase -0.419460226623402 1.20209798800426e-09 NA NA NA hsa-miR-425-5p TNC 3.07071373939774 4.02947460586085e-25 -1.22885204293992 0.0251580253603685 MirTarget -0.77347195632064 8.04287310910487e-22 NA NA NA hsa-miR-501-5p TNC 1.93654809410041 1.3779381780759e-10 -1.22885204293992 0.0251580253603685 miRNATAP -0.424449447117241 1.48148046827061e-06 NA NA NA hsa-miR-505-5p TNC 1.89243395287645 9.82003586561819e-12 -1.22885204293992 0.0251580253603685 MirTarget -0.701253157329603 1.22331831661449e-14 NA NA NA hsa-miR-590-3p TNC 2.59289455139753 1.03200520972022e-21 -1.22885204293992 0.0251580253603685 miRanda -0.380188102198532 7.16384228011859e-05 NA NA NA hsa-let-7a-5p TNFAIP3 0.618599506841644 2.76973453058748e-05 -1.62509801593269 1.6029261418853e-06 TargetScan;miRNATAP -0.420111000846509 0.000216775785489049 NA NA NA hsa-let-7d-5p TNFAIP3 1.33236798905207 1.1741085658466e-13 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.445219451938922 7.3054642669891e-07 NA NA NA hsa-let-7e-5p TNFAIP3 0.860104282510173 6.04758298373779e-05 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.326948708477224 2.12575428674536e-05 NA NA NA hsa-let-7f-5p TNFAIP3 0.495648727272215 0.00355972741198794 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.334343922657496 0.000693555536957464 NA NA NA hsa-let-7g-5p TNFAIP3 1.20061455355116 1.50237505511483e-12 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.514970749483471 6.60279188366171e-08 NA NA NA hsa-miR-107 TNFAIP3 1.30977326593435 1.30372468603965e-11 -1.62509801593269 1.6029261418853e-06 miRanda;miRNATAP -0.326897464892899 0.000101955056235218 NA NA NA hsa-miR-125a-5p TNFAIP3 0.599529391575274 0.0102300147180307 -1.62509801593269 1.6029261418853e-06 miRNAWalker2_validate;miRTarBase;miRanda -0.311690818854823 1.08307997815276e-05 NA NA NA hsa-miR-141-3p TNFAIP3 5.02396127982626 2.19224509139725e-24 -1.62509801593269 1.6029261418853e-06 TargetScan -0.222404109517195 5.77674703240202e-13 NA NA NA hsa-miR-19a-3p TNFAIP3 3.42309334186656 3.02671914353412e-28 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.166370619085426 0.000844856648957625 NA NA NA hsa-miR-19b-3p TNFAIP3 2.49529833021187 1.57028265846699e-23 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.245550445341764 9.28293570666511e-05 NA NA NA hsa-miR-23b-3p TNFAIP3 -0.251132426825047 0.150200321210792 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.343762927050195 0.000353762622619547 NA NA NA hsa-miR-330-3p TNFAIP3 0.876747334239085 0.00073709016089703 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.253862548005074 6.3658962793607e-05 NA NA NA hsa-miR-429 TNFAIP3 4.48815175680773 2.44117492218206e-17 -1.62509801593269 1.6029261418853e-06 miRanda -0.249954262558494 4.53694428345232e-18 NA NA NA hsa-miR-200c-3p TNFRSF11B 3.50132673580082 2.42716349086937e-15 0.521283699352378 0.32045562869016 miRNATAP -0.251159746127495 4.76271904987642e-06 NA NA NA hsa-miR-320a TNFRSF11B 0.438165828017084 0.0390159073347133 0.521283699352378 0.32045562869016 miRanda -0.509365923261957 2.09265016161344e-05 NA NA NA hsa-miR-320b TNFRSF11B 1.55692969039548 1.41071034251915e-08 0.521283699352378 0.32045562869016 miRanda -0.389510593493202 1.70320986000786e-05 NA NA NA hsa-miR-429 TNFRSF11B 4.48815175680773 2.44117492218206e-17 0.521283699352378 0.32045562869016 PITA;miRanda;miRNATAP -0.169600532887849 0.000208861559670817 NA NA NA hsa-let-7a-3p TPM1 1.42015538786275 7.03375209382654e-13 -2.65530585768087 2.50185615635583e-17 miRNATAP -0.585770370049464 1.33760262333991e-14 NA NA NA hsa-let-7b-3p TPM1 0.868207752019623 1.30460056774366e-05 -2.65530585768087 2.50185615635583e-17 miRNATAP -0.421206412861858 7.69440162986379e-08 NA NA NA hsa-miR-107 TPM1 1.30977326593435 1.30372468603965e-11 -2.65530585768087 2.50185615635583e-17 PITA;miRanda -0.808199084028722 1.21209859249108e-26 NA NA NA hsa-miR-125a-3p TPM1 1.24490295132072 5.26925231010328e-06 -2.65530585768087 2.50185615635583e-17 miRanda -0.160733931319085 0.00512005197210401 NA NA NA hsa-miR-1271-5p TPM1 0.970418832993172 0.000609742584380688 -2.65530585768087 2.50185615635583e-17 MirTarget -0.184471597687007 0.000920081843736612 NA NA NA hsa-miR-142-3p TPM1 2.75247908790621 1.45636065474764e-12 -2.65530585768087 2.50185615635583e-17 miRanda -0.110124776238656 0.00528384541850187 NA NA NA hsa-miR-183-5p TPM1 4.19757025992371 4.79612296318304e-26 -2.65530585768087 2.50185615635583e-17 MirTarget;miRNATAP -0.462030744525467 5.6325437448906e-43 NA NA NA hsa-miR-21-5p TPM1 2.73773305747971 1.38864982139576e-43 -2.65530585768087 2.50185615635583e-17 miRNAWalker2_validate;miRTarBase -0.289116342814918 5.96890063064487e-05 20952761;23558936 These two miRNAs have previously been identified as being overexpressed in MCF-7 breast cancer cells with miR-21 specifically implicated in down-regulating the tumor suppressor gene tropomyosin-1;Furthermore miR-21 mimic or inhibitor significantly reduced or increased the expression of PDCD4 and TPM1; MiR-21 is overexpressed in RCC tissue and modulates the growth apoptosis and cell cycle progression of RCC cells and regulates the expression of PDCD4 and TPM1 ;progression breast cancer;kidney renal cell cancer hsa-miR-29b-3p TPM1 1.65828197923813 1.02676780888141e-09 -2.65530585768087 2.50185615635583e-17 miRNATAP -0.353894201592496 2.83311655934018e-10 NA NA NA hsa-miR-29c-3p TPM1 -0.00968972577705429 0.97099586346872 -2.65530585768087 2.50185615635583e-17 miRNATAP -0.364274368255565 4.77169183942731e-10 NA NA NA hsa-miR-320a TPM1 0.438165828017084 0.0390159073347133 -2.65530585768087 2.50185615635583e-17 miRanda -0.649305645784583 1.53500964166287e-19 NA NA NA hsa-miR-320b TPM1 1.55692969039548 1.41071034251915e-08 -2.65530585768087 2.50185615635583e-17 miRanda -0.530897059374755 6.418483955899e-23 NA NA NA hsa-miR-33a-3p TPM1 1.72765312072219 1.51784443453521e-07 -2.65530585768087 2.50185615635583e-17 miRNATAP -0.502394378548372 1.93475129175183e-24 NA NA NA hsa-miR-34a-5p TPM1 1.9016323452565 1.43092834643601e-14 -2.65530585768087 2.50185615635583e-17 miRNAWalker2_validate -0.600882326868458 1.44424511680119e-24 NA NA NA hsa-miR-375 TPM1 1.13910305294079 0.0512283522214186 -2.65530585768087 2.50185615635583e-17 miRanda -0.116184267571717 1.412558253733e-05 NA NA NA hsa-miR-429 TPM1 4.48815175680773 2.44117492218206e-17 -2.65530585768087 2.50185615635583e-17 miRNATAP -0.352913537887681 1.26327654056495e-42 NA NA NA hsa-miR-455-5p TPM1 2.2582442061694 1.43472128037398e-13 -2.65530585768087 2.50185615635583e-17 miRanda -0.184237464033845 0.000233960316313226 NA NA NA hsa-miR-590-3p TPM1 2.59289455139753 1.03200520972022e-21 -2.65530585768087 2.50185615635583e-17 miRanda -0.558097154778622 4.0524218047793e-25 NA NA NA hsa-miR-944 TPM1 2.91186649218281 1.31574753528144e-06 -2.65530585768087 2.50185615635583e-17 mirMAP -0.252001066852298 2.62335782795254e-23 NA NA NA hsa-miR-96-5p TPM1 4.89433085814374 1.92000659886961e-31 -2.65530585768087 2.50185615635583e-17 MirTarget;TargetScan;miRNATAP -0.434696405271677 6.23872532253403e-41 NA NA NA hsa-miR-125a-3p TPM2 1.24490295132072 5.26925231010328e-06 -2.92445327558881 2.48809545670927e-12 miRanda;miRNATAP -0.328541951518518 1.17893980165848e-05 NA NA NA hsa-miR-15a-5p TPM2 2.34669284378787 1.69544424500258e-23 -2.92445327558881 2.48809545670927e-12 MirTarget -0.815513979036249 9.64301924790043e-25 NA NA NA hsa-miR-15b-5p TPM2 1.57112623124278 9.14247846750597e-13 -2.92445327558881 2.48809545670927e-12 MirTarget -1.01288173792848 3.04775224652593e-32 NA NA NA hsa-miR-16-5p TPM2 1.75824877145857 1.68592440033108e-16 -2.92445327558881 2.48809545670927e-12 MirTarget -1.06182737052936 3.6057943151065e-34 NA NA NA hsa-miR-185-5p TPM2 2.34016206907488 1.17481626642022e-26 -2.92445327558881 2.48809545670927e-12 MirTarget -0.913391609570401 1.54877986825605e-27 NA NA NA hsa-miR-320a TPM2 0.438165828017084 0.0390159073347133 -2.92445327558881 2.48809545670927e-12 miRanda -0.670047568578419 3.35373526225171e-12 NA NA NA hsa-miR-320b TPM2 1.55692969039548 1.41071034251915e-08 -2.92445327558881 2.48809545670927e-12 miRanda -0.693757527701676 1.24967400247358e-22 NA NA NA hsa-miR-339-5p TPM2 2.68710938429893 3.03134080808154e-16 -2.92445327558881 2.48809545670927e-12 miRanda -0.452141789873009 2.01815815457772e-14 NA NA NA hsa-miR-423-5p TPM2 0.963563145758616 9.86109015204915e-07 -2.92445327558881 2.48809545670927e-12 miRNATAP -1.06287156817431 6.20768781098172e-27 NA NA NA hsa-miR-491-5p TPM2 0.615770352820862 0.0418295628761654 -2.92445327558881 2.48809545670927e-12 miRanda -0.351594851089314 1.47148132946858e-06 NA NA NA hsa-miR-96-5p TPM2 4.89433085814374 1.92000659886961e-31 -2.92445327558881 2.48809545670927e-12 TargetScan -0.572645016552975 3.9897081404891e-41 NA NA NA hsa-miR-125a-5p TPM4 0.599529391575274 0.0102300147180307 -0.508649568232682 0.00410224160609163 miRNAWalker2_validate -0.125002215662329 0.000690862664113966 NA NA NA hsa-miR-192-5p TPM4 2.69002528723195 1.22990188194432e-16 -0.508649568232682 0.00410224160609163 miRNAWalker2_validate -0.141622838797281 1.67892729289668e-08 NA NA NA hsa-miR-2110 TPM4 1.16625590651194 6.4784195289885e-05 -0.508649568232682 0.00410224160609163 miRNATAP -0.138439152686249 9.26088588185767e-06 NA NA NA hsa-miR-30c-5p TPM4 0.778774633108 0.000285599212429136 -0.508649568232682 0.00410224160609163 miRNATAP -0.249556287231329 2.20265575460805e-10 NA NA NA hsa-miR-30d-5p TPM4 0.675423997639582 0.00270618816039773 -0.508649568232682 0.00410224160609163 miRNATAP -0.243201709137847 8.75368533402241e-11 NA NA NA hsa-miR-320a TPM4 0.438165828017084 0.0390159073347133 -0.508649568232682 0.00410224160609163 PITA;miRanda -0.162049312154117 6.45680282854534e-05 NA NA NA hsa-miR-320b TPM4 1.55692969039548 1.41071034251915e-08 -0.508649568232682 0.00410224160609163 PITA;miRanda -0.137358371816282 7.24095297157801e-06 NA NA NA hsa-miR-330-3p TPM4 0.876747334239085 0.00073709016089703 -0.508649568232682 0.00410224160609163 miRNATAP -0.18841223159117 6.91318457495199e-09 NA NA NA hsa-miR-339-5p TPM4 2.68710938429893 3.03134080808154e-16 -0.508649568232682 0.00410224160609163 miRanda -0.167848864404687 9.08351359785657e-12 NA NA NA hsa-miR-940 TPM4 3.21011374578759 2.7923171128495e-14 -0.508649568232682 0.00410224160609163 miRNAWalker2_validate -0.141752283071197 1.58357274931613e-11 NA NA NA hsa-let-7a-3p VCAM1 1.42015538786275 7.03375209382654e-13 -1.46399567013403 0.000518642539259761 MirTarget -0.42773678474992 2.40410098343425e-05 NA NA NA hsa-miR-200a-3p VCAM1 4.59434485520731 6.38952518573476e-18 -1.46399567013403 0.000518642539259761 miRNAWalker2_validate -0.343011191298116 1.26094779693856e-22 NA NA NA hsa-miR-590-3p VCAM1 2.59289455139753 1.03200520972022e-21 -1.46399567013403 0.000518642539259761 MirTarget;miRanda;mirMAP;miRNATAP -0.302321267338263 4.22218432740496e-05 NA NA NA hsa-miR-590-5p VCAM1 3.18300989862077 2.06813568597893e-26 -1.46399567013403 0.000518642539259761 miRanda -0.364292598929655 2.4803909709862e-08 NA NA NA hsa-miR-944 VCAM1 2.91186649218281 1.31574753528144e-06 -1.46399567013403 0.000518642539259761 mirMAP;miRNATAP -0.307291286113256 2.01547803774718e-20 NA NA NA hsa-miR-101-3p VCAN 0.522819989585461 0.00375627731618038 0.102699847387805 0.827138258538118 miRNATAP -0.844134490161432 1.19002862037389e-11 NA NA NA hsa-miR-103a-3p VCAN 1.44083190496858 1.53799939616416e-13 0.102699847387805 0.827138258538118 MirTarget;miRNATAP -1.00257181622406 4.37212539097064e-20 NA NA NA hsa-miR-107 VCAN 1.30977326593435 1.30372468603965e-11 0.102699847387805 0.827138258538118 MirTarget;miRanda;miRNATAP -0.848443088970762 4.63614248106508e-14 NA NA NA hsa-miR-126-5p VCAN 0.895338176458417 2.33372756450713e-05 0.102699847387805 0.827138258538118 mirMAP -0.376201885756388 0.000441678928038876 NA NA NA hsa-miR-128-3p VCAN 1.63756041666078 6.79626586407187e-14 0.102699847387805 0.827138258538118 MirTarget -0.701385379624996 1.43512839140961e-12 NA NA NA hsa-miR-129-5p VCAN -0.524170159980738 0.222582956006346 0.102699847387805 0.827138258538118 MirTarget;miRanda -0.186529311941678 0.000524086543428744 NA NA NA hsa-miR-141-3p VCAN 5.02396127982626 2.19224509139725e-24 0.102699847387805 0.827138258538118 MirTarget;TargetScan;miRNATAP -0.368944305303294 8.18079315504103e-19 NA NA NA hsa-miR-144-3p VCAN 0.658119849508907 0.146943823997989 0.102699847387805 0.827138258538118 miRNATAP -0.270754159315718 1.12614838643146e-07 NA NA NA hsa-miR-16-2-3p VCAN 2.31623086727196 4.29838149388188e-20 0.102699847387805 0.827138258538118 mirMAP -0.552331782888642 6.4663729866993e-11 NA NA NA hsa-miR-181c-5p VCAN 1.58587920618301 1.57506918816933e-10 0.102699847387805 0.827138258538118 MirTarget;miRNATAP -0.326406266897105 0.000278971230893014 NA NA NA hsa-miR-181d-5p VCAN 1.52204912185579 9.2693319057748e-08 0.102699847387805 0.827138258538118 MirTarget -0.2855535898579 0.000280207452095002 NA NA NA hsa-miR-186-5p VCAN 1.47445398888668 3.0781726595413e-15 0.102699847387805 0.827138258538118 MirTarget;miRNATAP -0.834117021328021 5.90104886988311e-13 NA NA NA hsa-miR-200a-3p VCAN 4.59434485520731 6.38952518573476e-18 0.102699847387805 0.827138258538118 MirTarget;miRNATAP -0.330450785777042 4.7142502246128e-17 NA NA NA hsa-miR-203a-3p VCAN 3.12352008343999 9.49391438647189e-07 0.102699847387805 0.827138258538118 MirTarget -0.131548825338486 0.000169834123068684 NA NA NA hsa-miR-224-3p VCAN 1.87536386559317 6.15140969394846e-05 0.102699847387805 0.827138258538118 MirTarget -0.290222436649375 4.94921019145075e-09 NA NA NA hsa-miR-28-5p VCAN 0.230152919654905 0.0742909586754846 0.102699847387805 0.827138258538118 miRanda -0.494003242839762 0.00664701722149698 NA NA NA hsa-miR-33a-3p VCAN 1.72765312072219 1.51784443453521e-07 0.102699847387805 0.827138258538118 mirMAP -0.589723865780527 3.84716164607621e-16 NA NA NA hsa-miR-33a-5p VCAN 3.79671563098419 1.15966309820345e-18 0.102699847387805 0.827138258538118 MirTarget -0.362863225600102 1.55275152939298e-11 NA NA NA hsa-miR-361-3p VCAN 1.07367425434318 1.73142774168958e-09 0.102699847387805 0.827138258538118 miRNATAP -0.479403170305228 0.00014579009647391 NA NA NA hsa-miR-421 VCAN 1.17791565395543 6.78526676976629e-06 0.102699847387805 0.827138258538118 miRanda -0.435039800525036 3.71269259710469e-07 NA NA NA hsa-miR-429 VCAN 4.48815175680773 2.44117492218206e-17 0.102699847387805 0.827138258538118 miRanda -0.295153035283152 1.61352192860129e-13 NA NA NA hsa-miR-590-3p VCAN 2.59289455139753 1.03200520972022e-21 0.102699847387805 0.827138258538118 miRanda -0.440540582153481 5.64915568635081e-08 NA NA NA hsa-miR-664a-3p VCAN 0.634721925861133 0.00520070178640421 0.102699847387805 0.827138258538118 mirMAP -0.612845970502343 5.22035482781942e-10 NA NA NA hsa-miR-944 VCAN 2.91186649218281 1.31574753528144e-06 0.102699847387805 0.827138258538118 mirMAP -0.227709521988 1.71105746010557e-09 NA NA NA hsa-miR-1-3p VEGFA -3.48370702447685 1.98579484008516e-13 0.471653090802802 0.0989904385682923 MirTarget -0.202978528176548 1.57292170658149e-13 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-133a-3p VEGFA -3.38501431117712 1.32336729742128e-13 0.471653090802802 0.0989904385682923 miRNAWalker2_validate -0.190996958246616 2.70660605752725e-11 NA NA NA hsa-miR-134-5p VEGFA 0.141163006984518 0.655334296084178 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase;MirTarget -0.180227374251871 3.58435465670397e-05 NA NA NA hsa-miR-145-5p VEGFA -1.55259331973517 9.97889123247165e-07 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase -0.277645238248207 4.72205041776188e-11 24966896;24781864;22472569 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically ;metastasis; bladder cancer;thyroid cancer;sarcoma hsa-miR-150-5p VEGFA -0.105827294491332 0.799351458244375 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase -0.164137084593398 6.0374913950269e-07 NA NA NA hsa-miR-195-5p VEGFA -1.44753678070504 8.70594292149271e-09 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase;MirTarget -0.21863878149299 5.11037236008283e-05 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA 0.592984035153911 0.0674836634175293 0.471653090802802 0.0989904385682923 miRanda;miRNATAP -0.205612739501636 1.1489897892283e-06 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA 0.218704279044827 0.519493319158441 0.471653090802802 0.0989904385682923 miRanda -0.175899050515122 1.43171320791549e-05 NA NA NA hsa-miR-29a-3p VEGFA -0.35074463683376 0.161238718982428 0.471653090802802 0.0989904385682923 MirTarget -0.313847513848792 9.68544057650496e-09 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-342-3p VEGFA 1.49115144672245 1.43879249744621e-07 0.471653090802802 0.0989904385682923 miRanda;miRNATAP -0.166390639835536 0.000539599594707828 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-374b-5p VEGFA 0.0654362503857184 0.722673188879465 0.471653090802802 0.0989904385682923 MirTarget -0.254824056474554 0.000792850845311603 NA NA NA hsa-miR-655-3p VEGFA 0.485339318272148 0.137014658258732 0.471653090802802 0.0989904385682923 MirTarget -0.164823030617487 0.000126415331270495 NA NA NA hsa-miR-128-3p VEGFC 1.63756041666078 6.79626586407187e-14 -0.457873556695705 0.178610332401836 miRNAWalker2_validate;MirTarget -0.377058704312277 2.16798927147771e-07 26722309;25001183 miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells;Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways metastasis; bladder cancer;lung squamous cell cancer hsa-miR-129-5p VIM -0.524170159980738 0.222582956006346 -1.53505864240645 4.15937440523538e-06 miRNATAP -0.110593290748965 0.00425400024641984 NA NA NA hsa-miR-1301-3p VIM 2.54959518791507 5.26618591274892e-18 -1.53505864240645 4.15937440523538e-06 miRNAWalker2_validate -0.321372645207541 7.63453865381851e-10 NA NA NA hsa-miR-16-5p VIM 1.75824877145857 1.68592440033108e-16 -1.53505864240645 4.15937440523538e-06 miRNAWalker2_validate -0.470139973573665 1.02545424621362e-10 NA NA NA hsa-miR-17-3p VIM 2.2704817679209 1.1667437320211e-22 -1.53505864240645 4.15937440523538e-06 miRNAWalker2_validate;miRNATAP -0.481964118600616 1.52996009766467e-13 19771525;23418359 The lack of miR-17-3p expression correlated with an increase in vimentin synthesis and tumorigenicity; Stable expression of miR-17-3p in the M12 subline reduced vimentin levels 85% and reverted growth to organized polarized acini in lrECM gels;In contrast the passenger strand miR-17-3p repressed expression of vimentin an intermediate filament with the ability to modulate metabolism and GalNT7 an enzyme that regulates metabolism of liver toxin galactosamine ; prostate cancer;liver cancer hsa-miR-26b-5p VIM 0.885393662798425 3.2116297961629e-06 -1.53505864240645 4.15937440523538e-06 miRNAWalker2_validate -0.408800594552695 1.54423296587781e-06 24890815 Increased expression of miR-26b inhibited the migration and invasiveness of HCC cell lines which was accompanied by decreased expression of the epithelial marker E-cadherin and increased expression of the mesenchymal marker vimentin at both the mRNA and protein expression levels liver cancer hsa-miR-30c-5p VIM 0.778774633108 0.000285599212429136 -1.53505864240645 4.15937440523538e-06 miRNAWalker2_validate;miRNATAP -0.484588018909367 8.38903011901652e-11 NA NA NA hsa-miR-30d-5p VIM 0.675423997639582 0.00270618816039773 -1.53505864240645 4.15937440523538e-06 miRNATAP -0.682327163924673 4.48782498389482e-23 NA NA NA hsa-miR-320a VIM 0.438165828017084 0.0390159073347133 -1.53505864240645 4.15937440523538e-06 PITA;miRanda;miRNATAP -0.42492585955383 2.65025911688313e-08 27448976 miR-320a was found to bind to the 3'UTR of both vimentin and USP14 transcripts and downregulate the expression of both proteins gastric cancer hsa-miR-320b VIM 1.55692969039548 1.41071034251915e-08 -1.53505864240645 4.15937440523538e-06 PITA;miRanda;miRNATAP -0.429306241106071 4.68456153561138e-14 NA NA NA hsa-miR-3607-3p VIM 2.68532138541128 5.66716351955047e-14 -1.53505864240645 4.15937440523538e-06 MirTarget -0.268746817668439 1.85095966797124e-09 NA NA NA hsa-miR-590-3p VIM 2.59289455139753 1.03200520972022e-21 -1.53505864240645 4.15937440523538e-06 mirMAP -0.322250504245616 3.05925105712622e-08 NA NA NA hsa-miR-590-5p VIM 3.18300989862077 2.06813568597893e-26 -1.53505864240645 4.15937440523538e-06 PITA;miRanda;miRNATAP -0.346808458824617 1.64423878413671e-11 NA NA NA hsa-miR-125a-3p WIPF1 1.24490295132072 5.26925231010328e-06 -1.36396473341553 1.25828143739996e-05 miRanda -0.206581139139998 0.000185440869367822 NA NA NA hsa-miR-1266-5p WIPF1 1.3763848124288 0.000876906064212958 -1.36396473341553 1.25828143739996e-05 MirTarget -0.309988645662609 2.15420735594682e-18 NA NA NA hsa-miR-129-5p WIPF1 -0.524170159980738 0.222582956006346 -1.36396473341553 1.25828143739996e-05 miRanda -0.134110532900747 0.000200173599209847 NA NA NA hsa-miR-141-3p WIPF1 5.02396127982626 2.19224509139725e-24 -1.36396473341553 1.25828143739996e-05 MirTarget;TargetScan;miRNATAP -0.370961510650937 6.77544747234292e-46 NA NA NA hsa-miR-15a-5p WIPF1 2.34669284378787 1.69544424500258e-23 -1.36396473341553 1.25828143739996e-05 miRNAWalker2_validate -0.429555399402037 9.67954952068467e-13 NA NA NA hsa-miR-16-5p WIPF1 1.75824877145857 1.68592440033108e-16 -1.36396473341553 1.25828143739996e-05 miRNAWalker2_validate -0.39272393224966 9.31258402790532e-09 NA NA NA hsa-miR-182-5p WIPF1 3.53923166221814 5.07781258121574e-21 -1.36396473341553 1.25828143739996e-05 MirTarget;miRNATAP -0.413413248840515 1.07298598160211e-30 NA NA NA hsa-miR-186-5p WIPF1 1.47445398888668 3.0781726595413e-15 -1.36396473341553 1.25828143739996e-05 MirTarget;mirMAP;miRNATAP -0.506882079004236 8.95366974634602e-11 NA NA NA hsa-miR-200a-3p WIPF1 4.59434485520731 6.38952518573476e-18 -1.36396473341553 1.25828143739996e-05 MirTarget;miRNATAP -0.353540466294149 2.18216466606487e-47 NA NA NA hsa-miR-200b-3p WIPF1 3.78235093249346 3.18343003239465e-14 -1.36396473341553 1.25828143739996e-05 MirTarget;TargetScan -0.38421023477438 3.50733856040564e-48 NA NA NA hsa-miR-200c-3p WIPF1 3.50132673580082 2.42716349086937e-15 -1.36396473341553 1.25828143739996e-05 MirTarget;miRNATAP -0.423943530965805 5.3342529515542e-46 NA NA NA hsa-miR-224-5p WIPF1 2.94107125335675 5.72194099515157e-08 -1.36396473341553 1.25828143739996e-05 mirMAP -0.142805755133646 1.73752916256004e-07 NA NA NA hsa-miR-30b-5p WIPF1 0.800822374912712 0.000133601914525413 -1.36396473341553 1.25828143739996e-05 MirTarget -0.48452776182145 1.06377909369004e-11 NA NA NA hsa-miR-30c-5p WIPF1 0.778774633108 0.000285599212429136 -1.36396473341553 1.25828143739996e-05 MirTarget;miRNATAP -0.506106058941809 2.92219947102558e-13 NA NA NA hsa-miR-30d-5p WIPF1 0.675423997639582 0.00270618816039773 -1.36396473341553 1.25828143739996e-05 MirTarget;miRNATAP -0.67217847802337 9.37791824934971e-26 NA NA NA hsa-miR-30e-5p WIPF1 1.23904909539663 1.35561917122157e-09 -1.36396473341553 1.25828143739996e-05 MirTarget -0.69013772460401 7.34650760294055e-23 NA NA NA hsa-miR-320a WIPF1 0.438165828017084 0.0390159073347133 -1.36396473341553 1.25828143739996e-05 miRanda -0.491924317653503 3.49427480929668e-12 NA NA NA hsa-miR-320b WIPF1 1.55692969039548 1.41071034251915e-08 -1.36396473341553 1.25828143739996e-05 miRanda -0.419850227689453 2.56033007604422e-15 NA NA NA hsa-miR-324-5p WIPF1 2.95683728155095 1.32960514360912e-20 -1.36396473341553 1.25828143739996e-05 miRanda -0.365866080180652 1.24839383201082e-16 NA NA NA hsa-miR-33a-3p WIPF1 1.72765312072219 1.51784443453521e-07 -1.36396473341553 1.25828143739996e-05 MirTarget -0.480053476593964 6.95626193011609e-24 NA NA NA hsa-miR-361-5p WIPF1 0.971859117235239 5.30236555707088e-09 -1.36396473341553 1.25828143739996e-05 miRanda -0.896457522127413 2.86277051479394e-25 NA NA NA hsa-miR-378a-5p WIPF1 0.223456081148306 0.386368843153575 -1.36396473341553 1.25828143739996e-05 MirTarget -0.461580682169096 1.02811111053761e-15 NA NA NA hsa-miR-429 WIPF1 4.48815175680773 2.44117492218206e-17 -1.36396473341553 1.25828143739996e-05 MirTarget;PITA;miRanda;miRNATAP -0.352188635797123 3.7491585074429e-46 NA NA NA hsa-miR-486-5p WIPF1 -0.194913133034028 0.607377798807705 -1.36396473341553 1.25828143739996e-05 miRanda -0.12065129156696 0.00270526652080131 NA NA NA hsa-miR-491-5p WIPF1 0.615770352820862 0.0418295628761654 -1.36396473341553 1.25828143739996e-05 miRanda -0.214974026282009 6.61183470193177e-05 NA NA NA hsa-miR-582-3p WIPF1 0.00876844181512659 0.977126166214707 -1.36396473341553 1.25828143739996e-05 PITA -0.303738860562097 6.49722102727656e-10 NA NA NA hsa-miR-590-3p WIPF1 2.59289455139753 1.03200520972022e-21 -1.36396473341553 1.25828143739996e-05 MirTarget;PITA;miRanda;miRNATAP -0.240698041585375 1.11681650236403e-05 NA NA NA hsa-miR-624-5p WIPF1 1.47043111118159 8.25080691741182e-09 -1.36396473341553 1.25828143739996e-05 MirTarget -0.223039609755827 0.000261993852694478 NA NA NA hsa-miR-664a-3p WIPF1 0.634721925861133 0.00520070178640421 -1.36396473341553 1.25828143739996e-05 MirTarget -0.391795636386487 3.54875780973871e-09 NA NA NA hsa-miR-664a-5p WIPF1 0.505019913598436 0.032933350691651 -1.36396473341553 1.25828143739996e-05 MirTarget -0.300587902005177 3.11292981487455e-06 NA NA NA hsa-miR-7-1-3p WIPF1 1.84950311431067 1.25300363397654e-13 -1.36396473341553 1.25828143739996e-05 MirTarget;mirMAP -0.274412022437412 3.4252175544859e-06 NA NA NA hsa-miR-96-5p WIPF1 4.89433085814374 1.92000659886961e-31 -1.36396473341553 1.25828143739996e-05 miRNATAP -0.362610119075191 2.89788295230179e-29 NA NA NA