miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-139-5p	A2ML1	0.285742771376759	0.544267131079626	-6.03609460105199	2.27709544982681e-53	miRanda	-0.251517758397988	0.00301165361367376		NA	NA	NA
hsa-miR-199a-5p	A2ML1	0.490183207757035	0.535727569028386	-6.03609460105199	2.27709544982681e-53	miRanda	-0.432571184240284	0.000217337915123593		NA	NA	NA
hsa-miR-199b-5p	A2ML1	0.419432234888138	0.503740858561878	-6.03609460105199	2.27709544982681e-53	miRanda	-0.296804748667495	0.00506696877048679		NA	NA	NA
hsa-miR-582-5p	ABCC8	-0.899123783418002	2.21001699541682e-05	5.38901897486962	5.96773434959069e-48	MirTarget;PITA;miRNATAP	-0.617958243121565	9.19614471588165e-11		NA	NA	NA
hsa-miR-197-3p	AGR2	-1.08455588312834	0.0773132237730592	5.38137410079408	2.413598645975e-17	miRNAWalker2_validate	-1.68574175780256	6.5547384787494e-48		NA	NA	NA
hsa-miR-361-5p	AGR2	-0.176908147169574	0.766834316027448	5.38137410079408	2.413598645975e-17	miRanda	-1.30944297393499	3.25322476462752e-08		NA	NA	NA
hsa-miR-590-3p	AGR2	-1.0148756365213	1.31613112773512e-09	5.38137410079408	2.413598645975e-17	miRanda	-0.809565281921211	2.84456843816196e-13		NA	NA	NA
hsa-miR-455-5p	AGR3	-1.08026558314669	0.00285665565397908	8.49655481067743	1.51651000895918e-55	MirTarget;miRanda	-1.45524738102036	8.18693111378524e-33		NA	NA	NA
hsa-miR-590-3p	AGR3	-1.0148756365213	1.31613112773512e-09	8.49655481067743	1.51651000895918e-55	miRanda	-1.19175849222747	9.88768334064096e-19		NA	NA	NA
hsa-miR-193a-3p	ANKRD30A	-0.204307820042279	0.505705966240602	6.06929123728687	2.23102282014818e-31	miRanda	-0.457069499844912	0.00514291409255925		NA	NA	NA
hsa-miR-107	ANKRD30B	-0.268297495992237	0.558574531375226	5.09293597838996	5.28210401654857e-43	miRanda	-0.856226968558973	1.28288799275869e-07		NA	NA	NA
hsa-miR-142-3p	ANKRD30B	-0.991543204185263	0.192118462717103	5.09293597838996	5.28210401654857e-43	miRanda	-0.339789144938944	3.85922440854509e-06		NA	NA	NA
hsa-miR-320b	ANKRD30B	-0.568525797794295	0.00392831837889986	5.09293597838996	5.28210401654857e-43	miRanda	-0.530638483499459	8.5517066064653e-07		NA	NA	NA
hsa-miR-455-5p	ANKRD30B	-1.08026558314669	0.00285665565397908	5.09293597838996	5.28210401654857e-43	miRanda	-1.1284152211834	4.49774178434938e-31		NA	NA	NA
hsa-miR-590-3p	ANKRD30B	-1.0148756365213	1.31613112773512e-09	5.09293597838996	5.28210401654857e-43	miRanda	-0.738250664560673	9.66215111390277e-12		NA	NA	NA
hsa-miR-130a-3p	C1orf64	-0.476792449834919	0.311911693805013	6.64975476478258	2.24131543058051e-47	mirMAP	-0.702593758350427	4.92713739609523e-09		NA	NA	NA
hsa-miR-17-3p	C1orf64	-1.16757140926577	0.0515926958491783	6.64975476478258	2.24131543058051e-47	mirMAP	-1.78398004063793	4.75223190769519e-44		NA	NA	NA
hsa-miR-301a-3p	C1orf64	-0.875123587836563	0.000205573029507074	6.64975476478258	2.24131543058051e-47	mirMAP	-0.937922045966999	3.43065570451609e-24		NA	NA	NA
hsa-miR-32-5p	C1orf64	-0.517092614793127	0.128792275423724	6.64975476478258	2.24131543058051e-47	mirMAP	-0.784661307435301	5.41738457823338e-09		NA	NA	NA
hsa-miR-454-3p	C1orf64	-0.335998597981737	0.142813015981699	6.64975476478258	2.24131543058051e-47	mirMAP	-0.696413614592968	1.02149832484951e-09		NA	NA	NA
hsa-miR-576-5p	C1orf64	-1.14232646292515	1.5482527416668e-05	6.64975476478258	2.24131543058051e-47	mirMAP	-1.54124404877186	3.44917447485306e-33		NA	NA	NA
hsa-let-7f-1-3p	ERBB4	-0.483477243132468	0.000326955823993582	5.03888981640947	3.72531070640511e-31	mirMAP	-0.553183235017237	4.20128842757918e-08		NA	NA	NA
hsa-miR-107	ERBB4	-0.268297495992237	0.558574531375226	5.03888981640947	3.72531070640511e-31	miRanda	-0.855347153920767	1.18282675367512e-09		NA	NA	NA
hsa-miR-125b-2-3p	ERBB4	-0.359573649386069	0.318121190990994	5.03888981640947	3.72531070640511e-31	MirTarget	-0.164848367344315	0.0310337686136616		NA	NA	NA
hsa-miR-130a-3p	ERBB4	-0.476792449834919	0.311911693805013	5.03888981640947	3.72531070640511e-31	miRNATAP	-0.562452691608941	2.75206032603849e-10		NA	NA	NA
hsa-miR-130b-3p	ERBB4	-1.08429702630329	8.08538282774541e-06	5.03888981640947	3.72531070640511e-31	miRNATAP	-1.07821928091649	4.74671059403323e-36		NA	NA	NA
hsa-miR-130b-5p	ERBB4	-1.27511172925769	2.44298782749422e-08	5.03888981640947	3.72531070640511e-31	miRNATAP	-0.86553972453535	7.04276245447973e-31		NA	NA	NA
hsa-miR-140-5p	ERBB4	-0.560629172359171	0.15833419399211	5.03888981640947	3.72531070640511e-31	PITA	-0.683275679037952	2.69850298884891e-09		NA	NA	NA
hsa-miR-142-5p	ERBB4	-1.03785020724081	0.0135213889049884	5.03888981640947	3.72531070640511e-31	PITA;mirMAP	-0.606955585207464	6.19801919435736e-17		NA	NA	NA
hsa-miR-146a-5p	ERBB4	-1.2285180020098	0.0137443767693466	5.03888981640947	3.72531070640511e-31	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.771575520291238	1.17420575349542e-22		NA	NA	NA
hsa-miR-146b-5p	ERBB4	-0.808743278481364	0.235429858527584	5.03888981640947	3.72531070640511e-31	PITA;miRNATAP	-1.13034904758223	6.83333476872108e-31		NA	NA	NA
hsa-miR-148a-5p	ERBB4	-0.834639893679635	0.0369294312938607	5.03888981640947	3.72531070640511e-31	mirMAP	-0.667114217154113	5.86281080130145e-12		NA	NA	NA
hsa-miR-155-5p	ERBB4	-1.04732700846557	0.0910530593317563	5.03888981640947	3.72531070640511e-31	mirMAP	-0.94286258454739	1.01774388894949e-31		NA	NA	NA
hsa-miR-181a-5p	ERBB4	-0.237484875152052	0.771216535490799	5.03888981640947	3.72531070640511e-31	mirMAP	-0.712832047447049	3.05402907910176e-09		NA	NA	NA
hsa-miR-181b-5p	ERBB4	-0.510915212624123	0.428661968630462	5.03888981640947	3.72531070640511e-31	mirMAP	-0.767721858342024	2.65150063570159e-14		NA	NA	NA
hsa-miR-181c-5p	ERBB4	-0.111949695743945	0.799773562464078	5.03888981640947	3.72531070640511e-31	mirMAP	-0.289676559563634	0.00533793038355396		NA	NA	NA
hsa-miR-193a-3p	ERBB4	-0.204307820042279	0.505705966240602	5.03888981640947	3.72531070640511e-31	MirTarget;miRNATAP	-0.339753224504527	0.00167919418348717	25391651;26655272	miR 193a 3p functions as a tumor suppressor in lung cancer by down regulating ERBB4; We identified specific targeting sites for miR-193a-3p in the 3'-UTR of ERBB4; We further identified an inverse correlation between miR-193a-3p levels and ERBB4 protein levels but not mRNA levels in lung cancer tissue samples; By overexpressing or knocking down miR-193a-3p in lung cancer cells we experimentally confirmed that miR-193a-3p directly recognizes the 3'-UTR of the ERBB4 transcript and regulates ERBB4 expression; Furthermore the biological consequences of the targeting of ERBB4 by miR-193a-3p were examined in vitro via cell proliferation invasion and apoptosis assays and in vivo using a mouse xenograft tumor model; We demonstrated that the repression of ERBB4 by miR-193a-3p suppressed proliferation and invasion and promoted apoptosis in lung cancer cells and that miR-193a-3p exerted an anti-tumor effect by negatively regulating ERBB4 in xenograft mice; Taken together our findings provide the first clues regarding the role of miR-193a-3p as a tumor suppressor in lung cancer through the inhibition of ERBB4 translation;Moreover mechanistic investigations showed that UCA1 upregulated the expression of miR-193a-3p target gene ERBB4 through competitively 'spongeing' miR-193a-3p; Overall we concluded that UCA1 functions as an oncogene in NSCLC acting mechanistically by upregulating ERBB4 in part through 'spongeing' miR-193a-3p	;	lung cancer;lung squamous cell cancer
hsa-miR-194-5p	ERBB4	-0.126349363776225	0.821659801191089	5.03888981640947	3.72531070640511e-31	miRNATAP	-0.275670223439778	0.0415000023578523		NA	NA	NA
hsa-miR-19a-3p	ERBB4	-1.2950258392105	0.000156651800953964	5.03888981640947	3.72531070640511e-31	miRNAWalker2_validate;miRTarBase;miRNATAP	-1.00394812037635	3.31202849940887e-40		NA	NA	NA
hsa-miR-19b-3p	ERBB4	-0.91460521785962	0.0782740184012206	5.03888981640947	3.72531070640511e-31	miRNATAP	-0.973773798408	7.97568425587549e-25		NA	NA	NA
hsa-miR-221-3p	ERBB4	-0.712497044453147	0.181022745511248	5.03888981640947	3.72531070640511e-31	miRNATAP	-1.13719282418678	7.18552772010395e-34		NA	NA	NA
hsa-miR-222-3p	ERBB4	-0.797554855187216	0.0452574164225719	5.03888981640947	3.72531070640511e-31	miRNATAP	-0.959765974462763	8.8889321634283e-28		NA	NA	NA
hsa-miR-23a-3p	ERBB4	-0.54276813252562	0.529180605483602	5.03888981640947	3.72531070640511e-31	miRNATAP	-1.31606560247383	3.40764391922014e-21		NA	NA	NA
hsa-miR-23b-3p	ERBB4	-0.294348229636633	0.672138810654215	5.03888981640947	3.72531070640511e-31	miRNATAP	-0.477988421608263	6.13999685736269e-05		NA	NA	NA
hsa-miR-27a-5p	ERBB4	-0.331639003884912	0.296553314578201	5.03888981640947	3.72531070640511e-31	miRNATAP	-0.218143555211365	0.0104670001462383		NA	NA	NA
hsa-miR-301a-3p	ERBB4	-0.875123587836563	0.000205573029507074	5.03888981640947	3.72531070640511e-31	miRNATAP	-0.628226881417503	9.72331311229569e-20		NA	NA	NA
hsa-miR-30e-5p	ERBB4	-0.615579959308297	0.512008315212806	5.03888981640947	3.72531070640511e-31	mirMAP	-1.20913744423238	1.81916316325587e-17		NA	NA	NA
hsa-miR-330-3p	ERBB4	-0.280227597524446	0.0847083757953072	5.03888981640947	3.72531070640511e-31	MirTarget;PITA;miRNATAP	-0.320702537200979	0.00109448229099187		NA	NA	NA
hsa-miR-330-5p	ERBB4	-0.446568912618355	0.21605173591523	5.03888981640947	3.72531070640511e-31	miRNATAP	-0.71083230091054	1.25321486544143e-10		NA	NA	NA
hsa-miR-361-5p	ERBB4	-0.176908147169574	0.766834316027448	5.03888981640947	3.72531070640511e-31	miRanda;mirMAP	-1.22825146131928	9.17158724791728e-10		NA	NA	NA
hsa-miR-362-5p	ERBB4	-0.819551386113107	0.002236888463715	5.03888981640947	3.72531070640511e-31	PITA;TargetScan;miRNATAP	-0.979727308009705	2.12109407947267e-32		NA	NA	NA
hsa-miR-374a-3p	ERBB4	-0.409763684633608	0.569548862750345	5.03888981640947	3.72531070640511e-31	MirTarget;mirMAP;miRNATAP	-0.817893780229992	2.70946684003894e-08		NA	NA	NA
hsa-miR-374a-5p	ERBB4	-0.46017658103009	0.233995386626867	5.03888981640947	3.72531070640511e-31	mirMAP	-0.85356650445241	5.70142966899516e-09		NA	NA	NA
hsa-miR-374b-5p	ERBB4	-0.44830162044649	0.30848097286561	5.03888981640947	3.72531070640511e-31	mirMAP	-0.809343968543253	1.97057096645665e-08		NA	NA	NA
hsa-miR-429	ERBB4	-0.130422888141429	0.785729890550289	5.03888981640947	3.72531070640511e-31	PITA;miRanda;miRNATAP	-0.132997468006583	0.0431936949788559		NA	NA	NA
hsa-miR-452-5p	ERBB4	-2.16446399841248	2.21139030940835e-06	5.03888981640947	3.72531070640511e-31	mirMAP	-0.701884213446386	2.37990608843616e-40		NA	NA	NA
hsa-miR-454-3p	ERBB4	-0.335998597981737	0.142813015981699	5.03888981640947	3.72531070640511e-31	miRNATAP	-0.425433484838218	5.68728902265879e-07		NA	NA	NA
hsa-miR-455-5p	ERBB4	-1.08026558314669	0.00285665565397908	5.03888981640947	3.72531070640511e-31	miRNATAP	-1.25797618830575	9.36949278569158e-53		NA	NA	NA
hsa-miR-485-3p	ERBB4	-0.115480400236019	0.5621414853468	5.03888981640947	3.72531070640511e-31	mirMAP	-0.190407068961608	0.0352512487476173		NA	NA	NA
hsa-miR-576-5p	ERBB4	-1.14232646292515	1.5482527416668e-05	5.03888981640947	3.72531070640511e-31	PITA	-1.03921764612909	3.25130186720161e-27		NA	NA	NA
hsa-miR-584-5p	ERBB4	-1.62285844300086	0.000182011553898811	5.03888981640947	3.72531070640511e-31	mirMAP	-1.04946332355711	1.06807000086008e-45		NA	NA	NA
hsa-miR-589-3p	ERBB4	-1.01260581601727	1.23682952986115e-11	5.03888981640947	3.72531070640511e-31	mirMAP	-0.636388285183413	7.27685924015814e-17		NA	NA	NA
hsa-miR-589-5p	ERBB4	-0.445641941397064	0.318280321907762	5.03888981640947	3.72531070640511e-31	miRNATAP	-1.17606441834772	9.32804865258599e-18		NA	NA	NA
hsa-miR-590-3p	ERBB4	-1.0148756365213	1.31613112773512e-09	5.03888981640947	3.72531070640511e-31	miRanda;mirMAP	-0.937739257163784	4.90281349296452e-24		NA	NA	NA
hsa-miR-660-5p	ERBB4	-0.758543542438761	0.0638860679428602	5.03888981640947	3.72531070640511e-31	mirMAP;miRNATAP	-1.52542779983287	1.21158852836455e-48		NA	NA	NA
hsa-let-7f-1-3p	ESR1	-0.483477243132468	0.000326955823993582	6.2801060545712	7.5648147610038e-25	mirMAP	-0.596241706169458	3.20952205563396e-09		NA	NA	NA
hsa-miR-107	ESR1	-0.268297495992237	0.558574531375226	6.2801060545712	7.5648147610038e-25	PITA;miRanda;miRNATAP	-0.52080715961539	0.000233342922472232	26033453	Estrogen-receptor negative tumors displayed higher concentrations of circulating miR-107 than their counterparts p = 0.035; However overexpression of miR-107 in MCF-7 cells did not downregulate estrogen receptor protein		breast cancer
hsa-miR-125b-2-3p	ESR1	-0.359573649386069	0.318121190990994	6.2801060545712	7.5648147610038e-25	mirMAP	-0.483275866876461	1.62125592433327e-10		NA	NA	NA
hsa-miR-130a-3p	ESR1	-0.476792449834919	0.311911693805013	6.2801060545712	7.5648147610038e-25	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.706399613843885	1.37851433639071e-15		NA	NA	NA
hsa-miR-130b-3p	ESR1	-1.08429702630329	8.08538282774541e-06	6.2801060545712	7.5648147610038e-25	miRNATAP	-1.01925027311659	4.1467527319139e-32		NA	NA	NA
hsa-miR-130b-5p	ESR1	-1.27511172925769	2.44298782749422e-08	6.2801060545712	7.5648147610038e-25	mirMAP	-0.791486008201584	8.6427467329093e-26		NA	NA	NA
hsa-miR-132-3p	ESR1	-0.222018538395312	0.64620325934298	6.2801060545712	7.5648147610038e-25	mirMAP	-0.720879577095591	2.43271021786454e-07		NA	NA	NA
hsa-miR-146b-3p	ESR1	-0.692756784759197	0.166436404338511	6.2801060545712	7.5648147610038e-25	miRNATAP	-1.1068135719937	1.72302453294009e-27		NA	NA	NA
hsa-miR-148a-3p	ESR1	-0.767676900062211	0.499803442480461	6.2801060545712	7.5648147610038e-25	miRNATAP	-0.543683433433829	1.85634766952e-08	25063027	miR-148a plays an important role in regulation of cancer cell proliferation and cancer invasion and down-regulation of miR-148a has been reported in both estrogen receptor ER positive and triple-negative TN breast cancer		breast cancer
hsa-miR-17-5p	ESR1	-1.49037002937747	0.0190349160681147	6.2801060545712	7.5648147610038e-25	TargetScan	-1.19544166824122	3.22289120464407e-48		NA	NA	NA
hsa-miR-181a-5p	ESR1	-0.237484875152052	0.771216535490799	6.2801060545712	7.5648147610038e-25	miRNATAP	-0.642051980641508	9.70999220835469e-08		NA	NA	NA
hsa-miR-181b-5p	ESR1	-0.510915212624123	0.428661968630462	6.2801060545712	7.5648147610038e-25	miRNATAP	-0.755926645065685	6.52391349261287e-14		NA	NA	NA
hsa-miR-181c-5p	ESR1	-0.111949695743945	0.799773562464078	6.2801060545712	7.5648147610038e-25	miRNATAP	-0.26630626006218	0.0104222586041951		NA	NA	NA
hsa-miR-186-5p	ESR1	-0.93345861300789	0.120522341354577	6.2801060545712	7.5648147610038e-25	mirMAP	-1.40338420717257	1.311041694549e-32		NA	NA	NA
hsa-miR-18a-5p	ESR1	-2.01880623447922	1.00056634123849e-15	6.2801060545712	7.5648147610038e-25	miRNAWalker2_validate;miRTarBase;miRNATAP	-1.14044745041939	3.5647791599912e-74	19027010;24975878	MicroRNA 18a prevents estrogen receptor alpha expression promoting proliferation of hepatocellular carcinoma cells; The gene ESR1 which encodes the estrogen receptor-alpha ERalpha was identified as a target of miR-18a miR-18a can repress ERalpha translation by binding to its mRNA at the 3' untranslated region;Elevated p53 promotes the processing of miR 18a to decrease estrogen receptor α in female hepatocellular carcinoma; Our previous study identified that estrogen receptor alpha ERα protein is downregulated in 60% of female HCC cases via a miR-18a elevation mediated suppression of ERα translation	;	liver cancer;liver cancer
hsa-miR-19a-3p	ESR1	-1.2950258392105	0.000156651800953964	6.2801060545712	7.5648147610038e-25	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.918018971888875	2.34175436155262e-33	26416600	We speculate that miR-19a might be co-expressed with lncRNA-DLEU1 to co-regulate the expression of ESR1 which influences the occurrence and development of breast cancer cells with different levels of ER expression		breast cancer
hsa-miR-19b-3p	ESR1	-0.91460521785962	0.0782740184012206	6.2801060545712	7.5648147610038e-25	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.955532284971413	6.21638783917986e-24		NA	NA	NA
hsa-miR-20b-5p	ESR1	-0.536473695296692	0.135049762553568	6.2801060545712	7.5648147610038e-25	miRNAWalker2_validate;miRTarBase	-0.145222488631583	0.0144616347030701		NA	NA	NA
hsa-miR-21-3p	ESR1	-0.207501055780932	0.796305503641879	6.2801060545712	7.5648147610038e-25	mirMAP	-0.31824892123099	0.000480950639571142	19264808;25337203;21131358;25969534	miR-21 is higher in ER alpha positive than negative tumors but no one has examined how estradiol E2 regulates miR-21 in breast cancer cells; The E2-induced reduction in miR-21 was inhibited by 4-hydroxytamoxifen 4-OHT ICI 182 780 Faslodex and siRNA ER alpha indicating that the suppression is ER alpha-mediated; ER alpha and ER beta agonists PPT and DPN inhibited and 4-OHT increased miR-21 expression; These results are the first to demonstrate that E2 represses the expression of an oncogenic miRNA miR-21 by activating estrogen receptor in MCF-7 cells;Odds ratios ORs showed that miR-21 expression was closely associated with estrogen receptor ER progesterone receptor PR lymph node metastasis histological grade Her2/neu;Induction of miR 21 by retinoic acid in estrogen receptor positive breast carcinoma cells: biological correlates and molecular targets;Dehydroepiandrosterone Activation of G protein coupled Estrogen Receptor Rapidly Stimulates MicroRNA 21 Transcription in Human Hepatocellular Carcinoma Cells	;metastasis;;	breast cancer;breast cancer;breast cancer;liver cancer
hsa-miR-212-3p	ESR1	-0.704517154494958	8.54335038639114e-05	6.2801060545712	7.5648147610038e-25	mirMAP	-0.788572914463833	4.10000727664385e-17		NA	NA	NA
hsa-miR-217	ESR1	-0.384194440187457	0.253924920834776	6.2801060545712	7.5648147610038e-25	miRanda	-0.310750459089371	3.62474341001295e-05		NA	NA	NA
hsa-miR-22-3p	ESR1	-0.12525128016836	0.918681225458684	6.2801060545712	7.5648147610038e-25	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.973519657734076	1.26054178882888e-08	20180843;24715036	An estrogen receptor alpha suppressor microRNA 22 is downregulated in estrogen receptor alpha positive human breast cancer cell lines and clinical samples;miR 22 inhibits proliferation and invasion in estrogen receptor α positive endometrial endometrioid carcinomas cells	;	breast cancer;endometrial cancer
hsa-miR-221-3p	ESR1	-0.712497044453147	0.181022745511248	6.2801060545712	7.5648147610038e-25	miRNAWalker2_validate;miRNATAP	-1.00581969887263	2.15975574415267e-26	25483016	HBx protein induced upregulation of microRNA 221 promotes aberrant proliferation in HBV‑related hepatocellular carcinoma by targeting estrogen receptor α		liver cancer
hsa-miR-222-3p	ESR1	-0.797554855187216	0.0452574164225719	6.2801060545712	7.5648147610038e-25	miRNAWalker2_validate;miRNATAP	-0.830321095773127	7.33101503145802e-21		NA	NA	NA
hsa-miR-29a-5p	ESR1	-0.691508893020933	0.0006476121951632	6.2801060545712	7.5648147610038e-25	mirMAP	-0.571044888801489	1.46744006558388e-08	21761362	MiR-222/221 which target ESR1 itself and miR-29a are predicted to target the 3' UTR of Dicer1		breast cancer
hsa-miR-301a-3p	ESR1	-0.875123587836563	0.000205573029507074	6.2801060545712	7.5648147610038e-25	miRNATAP	-0.4879131572964	2.64298055602113e-12		NA	NA	NA
hsa-miR-30e-3p	ESR1	-0.337486437579047	0.721461710968778	6.2801060545712	7.5648147610038e-25	mirMAP	-0.753498152824586	2.85377943758404e-06		NA	NA	NA
hsa-miR-320b	ESR1	-0.568525797794295	0.00392831837889986	6.2801060545712	7.5648147610038e-25	PITA;mirMAP	-0.40093763379491	1.94618105456694e-05		NA	NA	NA
hsa-miR-324-5p	ESR1	-0.857987753799243	0.00796931745099012	6.2801060545712	7.5648147610038e-25	PITA	-0.624966417762192	2.33211335642968e-14		NA	NA	NA
hsa-miR-330-3p	ESR1	-0.280227597524446	0.0847083757953072	6.2801060545712	7.5648147610038e-25	PITA;mirMAP;miRNATAP	-0.228825753894928	0.0199551204210749		NA	NA	NA
hsa-miR-361-5p	ESR1	-0.176908147169574	0.766834316027448	6.2801060545712	7.5648147610038e-25	miRNATAP	-1.09655592249789	4.84366481208876e-08		NA	NA	NA
hsa-miR-374a-3p	ESR1	-0.409763684633608	0.569548862750345	6.2801060545712	7.5648147610038e-25	miRNATAP	-1.23188723310908	2.28097851123598e-17		NA	NA	NA
hsa-miR-374a-5p	ESR1	-0.46017658103009	0.233995386626867	6.2801060545712	7.5648147610038e-25	mirMAP	-1.37625560102013	1.22284318507823e-21		NA	NA	NA
hsa-miR-374b-5p	ESR1	-0.44830162044649	0.30848097286561	6.2801060545712	7.5648147610038e-25	mirMAP	-1.26207513301612	6.57262817753244e-19		NA	NA	NA
hsa-miR-409-3p	ESR1	0.0835184033903182	0.804405037964646	6.2801060545712	7.5648147610038e-25	mirMAP	-0.262209139504514	0.00928458513174569		NA	NA	NA
hsa-miR-450b-5p	ESR1	-0.2451142386807	0.439891078482232	6.2801060545712	7.5648147610038e-25	mirMAP;miRNATAP	-0.305683223774132	0.00211979139713611		NA	NA	NA
hsa-miR-454-3p	ESR1	-0.335998597981737	0.142813015981699	6.2801060545712	7.5648147610038e-25	miRNATAP	-0.280950924792971	0.000999084364001009		NA	NA	NA
hsa-miR-455-5p	ESR1	-1.08026558314669	0.00285665565397908	6.2801060545712	7.5648147610038e-25	miRanda	-1.08611399370055	2.05209360291252e-38		NA	NA	NA
hsa-miR-589-3p	ESR1	-1.01260581601727	1.23682952986115e-11	6.2801060545712	7.5648147610038e-25	mirMAP	-0.64455536100727	2.7086347347523e-17		NA	NA	NA
hsa-miR-590-3p	ESR1	-1.0148756365213	1.31613112773512e-09	6.2801060545712	7.5648147610038e-25	miRanda;mirMAP;miRNATAP	-0.88040206816541	2.9880939993017e-21		NA	NA	NA
hsa-miR-660-5p	ESR1	-0.758543542438761	0.0638860679428602	6.2801060545712	7.5648147610038e-25	miRNATAP	-1.24125009028228	1.87735356236176e-31		NA	NA	NA
hsa-miR-9-5p	ESR1	-2.25238007294585	0.00288819072983746	6.2801060545712	7.5648147610038e-25	mirMAP;miRNATAP	-0.571692276785571	1.09806234668515e-34	22723919	Higher expression of miR-9 was significantly associated with breast cancer LR in all cases as well as the subset of estrogen receptor ER positive cases p = 0.02		breast cancer
hsa-miR-342-3p	FABP7	0.881451816155686	0.151673451876559	-5.01937232011987	5.34898908328044e-30	miRanda	-1.05685928900075	8.2597488891093e-21		NA	NA	NA
hsa-miR-125a-3p	GP2	-0.0667349019563686	0.717243319546478	6.45775524888344	4.9908306710103e-46	miRanda	-0.785022484413352	2.82181265569315e-07		NA	NA	NA
hsa-miR-29a-5p	GP2	-0.691508893020933	0.0006476121951632	6.45775524888344	4.9908306710103e-46	mirMAP	-1.01082739810653	3.06483168989559e-13		NA	NA	NA
hsa-let-7d-5p	KCNJ3	-0.539921918119648	0.339610079714007	5.73007742004319	7.23468262461318e-34	miRNATAP	-0.511905282012612	0.00647774756846278		NA	NA	NA
hsa-let-7i-5p	KCNJ3	-0.384259273326238	0.565071058110532	5.73007742004319	7.23468262461318e-34	miRNATAP	-2.35153125380886	3.73332858691052e-17		NA	NA	NA
hsa-miR-140-5p	KCNJ3	-0.560629172359171	0.15833419399211	5.73007742004319	7.23468262461318e-34	miRanda	-0.725191554383511	1.19782718296441e-05		NA	NA	NA
hsa-miR-142-5p	KCNJ3	-1.03785020724081	0.0135213889049884	5.73007742004319	7.23468262461318e-34	PITA;mirMAP;miRNATAP	-0.568400819786477	7.02783300455738e-08		NA	NA	NA
hsa-miR-154-5p	KCNJ3	0.1065259557972	0.601434049614531	5.73007742004319	7.23468262461318e-34	mirMAP	-0.254655176040475	0.0278787378776554		NA	NA	NA
hsa-miR-199b-5p	KCNJ3	0.419432234888138	0.503740858561878	5.73007742004319	7.23468262461318e-34	miRanda	-0.254896813794878	0.0466741878264066		NA	NA	NA
hsa-miR-25-3p	KCNJ3	-0.664438541167009	0.510072913206212	5.73007742004319	7.23468262461318e-34	miRNATAP	-1.30860737040788	2.44513068983087e-09		NA	NA	NA
hsa-miR-27a-3p	KCNJ3	-0.578130235121682	0.445858318725182	5.73007742004319	7.23468262461318e-34	miRNATAP	-1.34815886313708	8.6100090005687e-13		NA	NA	NA
hsa-miR-27b-3p	KCNJ3	-0.248272670267601	0.725480792049685	5.73007742004319	7.23468262461318e-34	miRNATAP	-1.06422526774286	1.40699141473909e-09		NA	NA	NA
hsa-miR-32-5p	KCNJ3	-0.517092614793127	0.128792275423724	5.73007742004319	7.23468262461318e-34	miRNATAP	-0.307947841026663	0.033338193758541		NA	NA	NA
hsa-miR-361-5p	KCNJ3	-0.176908147169574	0.766834316027448	5.73007742004319	7.23468262461318e-34	MirTarget;PITA;miRanda	-0.993792577125429	0.000613351962798975		NA	NA	NA
hsa-miR-369-3p	KCNJ3	-0.00451834633827408	0.983536876658556	5.73007742004319	7.23468262461318e-34	PITA;miRNATAP	-0.675815319269046	6.25779491907507e-07		NA	NA	NA
hsa-miR-374a-3p	KCNJ3	-0.409763684633608	0.569548862750345	5.73007742004319	7.23468262461318e-34	MirTarget;miRNATAP	-0.900349287031127	2.16156621745815e-05		NA	NA	NA
hsa-miR-500a-3p	KCNJ3	-0.886171273818966	0.131041060826727	5.73007742004319	7.23468262461318e-34	MirTarget;miRNATAP	-1.08168593013236	1.74775437715754e-11		NA	NA	NA
hsa-miR-542-3p	KCNJ3	-0.0930649843870262	0.879535497573486	5.73007742004319	7.23468262461318e-34	miRNATAP	-0.3649873425621	0.0131676487658412		NA	NA	NA
hsa-miR-590-3p	KCNJ3	-1.0148756365213	1.31613112773512e-09	5.73007742004319	7.23468262461318e-34	PITA;miRanda;mirMAP;miRNATAP	-0.520189519853608	0.000139568460954844		NA	NA	NA
hsa-miR-590-5p	KCNJ3	-1.37026733313115	4.69117952935435e-08	5.73007742004319	7.23468262461318e-34	miRanda	-0.701344608631069	6.77506053510114e-08		NA	NA	NA
hsa-miR-92a-3p	KCNJ3	-0.954856576373283	0.33625426883111	5.73007742004319	7.23468262461318e-34	miRNATAP	-1.21275816412832	3.12756098037022e-13		NA	NA	NA
hsa-miR-222-5p	NR2E3	-0.847818989735893	1.9764188573418e-06	6.18279082101093	1.18512793702806e-22	MirTarget	-0.621263843095637	2.1507007523436e-08		NA	NA	NA
hsa-miR-30e-3p	NR2E3	-0.337486437579047	0.721461710968778	6.18279082101093	1.18512793702806e-22	MirTarget	-0.465483961597252	0.0311019574977157		NA	NA	NA
hsa-miR-320b	NR2E3	-0.568525797794295	0.00392831837889986	6.18279082101093	1.18512793702806e-22	MirTarget;miRanda	-0.378578550249145	0.00258203006911546		NA	NA	NA
hsa-miR-330-5p	NR2E3	-0.446568912618355	0.21605173591523	6.18279082101093	1.18512793702806e-22	miRanda	-0.389139138038554	0.00896959900274092		NA	NA	NA
hsa-miR-339-5p	NR2E3	-0.158699904584273	0.692996944889432	6.18279082101093	1.18512793702806e-22	miRanda	-0.301076956794125	0.0279864225805859		NA	NA	NA
hsa-miR-590-3p	NR2E3	-1.0148756365213	1.31613112773512e-09	6.18279082101093	1.18512793702806e-22	miRanda	-0.689275676392869	4.8962742358497e-08		NA	NA	NA
hsa-miR-744-3p	NR2E3	-0.837495747258205	0.00211080674333081	6.18279082101093	1.18512793702806e-22	MirTarget	-0.443981137906928	1.35683857572033e-06		NA	NA	NA
hsa-miR-125a-3p	PGLYRP2	-0.0667349019563686	0.717243319546478	5.18523536739592	2.5516331692755e-46	miRanda	-0.374767206908032	0.00290452853135731		NA	NA	NA
hsa-miR-106a-5p	PGR	-0.987254152228833	0.000671509970809012	5.0585781178635	1.5277201772991e-24	mirMAP	-0.435870719400217	1.96287979162583e-07		NA	NA	NA
hsa-miR-106b-5p	PGR	-0.940622824093885	0.10997290155882	5.0585781178635	1.5277201772991e-24	mirMAP	-1.49320859370265	1.71945429171287e-39		NA	NA	NA
hsa-miR-130b-3p	PGR	-1.08429702630329	8.08538282774541e-06	5.0585781178635	1.5277201772991e-24	mirMAP	-1.1454801113396	3.24211042401719e-35		NA	NA	NA
hsa-miR-142-5p	PGR	-1.03785020724081	0.0135213889049884	5.0585781178635	1.5277201772991e-24	mirMAP	-0.537869486326381	7.35130389735964e-12		NA	NA	NA
hsa-miR-155-5p	PGR	-1.04732700846557	0.0910530593317563	5.0585781178635	1.5277201772991e-24	mirMAP	-0.805167281959542	4.61565815289051e-20	20388420;19454029;23162645	It's indicated that the up-regulation of miR-155 expression was associated with advanced TNM clinical stage median 0.316 0.358 and 0.417 respectively for stage I II and III tumor P = 0.002 lymph node metastasis median 0.383 and 0.355 respectively for cases with positive and negative lymph nodes P = 0.034 higher proliferation index median 0.387 and 0.353 respectively for cases with high proliferation index Ki67 > 10% and low proliferation index Ki67 ≤ 10% P = 0.019 estrogen receptor-positive 0.367 and 0.318 respectively for cases with positive estrogen receptor and negative group P = 0.041 and progesterone receptor-positive 0.398 and 0.335 respectively for cases with positive progesterone receptor and negative group P = 0.029 in patients with breast cancer; The expression of miR-155 is up-regulated in primary breast cancer especially in patients with positive estrogen and progesterone receptor;While the expression of all three miRNAs was similar in samples from healthy women compared to those with breast cancer women with progesterone receptor PR p = 0.016 positive tumors had higher miR-155 expression than tumors that were negative for these receptors;miR 155 and miR 31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status; The expression levels of miR-155 but not miR-31 were inversely correlated with estrogen receptor ER and progesterone receptor PR expression ER r=-0.353 P=0.003; PR r=-0.357 P=0.003	staging;metastasis;;	breast cancer;breast cancer;breast cancer
hsa-miR-17-3p	PGR	-1.16757140926577	0.0515926958491783	5.0585781178635	1.5277201772991e-24	mirMAP	-1.40855584756557	5.19998879999309e-43		NA	NA	NA
hsa-miR-17-5p	PGR	-1.49037002937747	0.0190349160681147	5.0585781178635	1.5277201772991e-24	mirMAP	-1.21195689882893	1.78173651879557e-42		NA	NA	NA
hsa-miR-186-5p	PGR	-0.93345861300789	0.120522341354577	5.0585781178635	1.5277201772991e-24	mirMAP	-1.1820513354115	4.97019506724808e-20		NA	NA	NA
hsa-miR-192-5p	PGR	-0.51379465228502	0.412351178690012	5.0585781178635	1.5277201772991e-24	mirMAP	-0.651953241615696	1.71437157747465e-10		NA	NA	NA
hsa-miR-20a-5p	PGR	-1.15371517761644	0.0566685394151956	5.0585781178635	1.5277201772991e-24	mirMAP	-1.09903732647663	9.15052344511068e-32		NA	NA	NA
hsa-miR-23a-3p	PGR	-0.54276813252562	0.529180605483602	5.0585781178635	1.5277201772991e-24	mirMAP	-0.967991528353015	1.79455927260641e-10		NA	NA	NA
hsa-miR-23b-3p	PGR	-0.294348229636633	0.672138810654215	5.0585781178635	1.5277201772991e-24	mirMAP	-0.319249570442515	0.0129904024181783		NA	NA	NA
hsa-miR-29a-5p	PGR	-0.691508893020933	0.0006476121951632	5.0585781178635	1.5277201772991e-24	mirMAP	-0.437634003093851	5.81046031525968e-05		NA	NA	NA
hsa-miR-301a-3p	PGR	-0.875123587836563	0.000205573029507074	5.0585781178635	1.5277201772991e-24	mirMAP	-0.715649274868087	4.00592002714684e-22		NA	NA	NA
hsa-miR-30e-5p	PGR	-0.615579959308297	0.512008315212806	5.0585781178635	1.5277201772991e-24	mirMAP	-1.1045494989539	6.57888948050497e-13		NA	NA	NA
hsa-miR-33a-5p	PGR	-1.10901023083759	2.94502466535875e-05	5.0585781178635	1.5277201772991e-24	mirMAP	-0.501993553513481	3.43191587434318e-15		NA	NA	NA
hsa-miR-374a-5p	PGR	-0.46017658103009	0.233995386626867	5.0585781178635	1.5277201772991e-24	mirMAP	-1.05598295244096	1.69199366880647e-11		NA	NA	NA
hsa-miR-374b-5p	PGR	-0.44830162044649	0.30848097286561	5.0585781178635	1.5277201772991e-24	mirMAP	-1.06227321978092	5.52271340780455e-12		NA	NA	NA
hsa-miR-452-5p	PGR	-2.16446399841248	2.21139030940835e-06	5.0585781178635	1.5277201772991e-24	mirMAP	-0.57638681638652	2.82946527475521e-23		NA	NA	NA
hsa-miR-454-3p	PGR	-0.335998597981737	0.142813015981699	5.0585781178635	1.5277201772991e-24	mirMAP	-0.56495782844598	5.40700267146444e-10		NA	NA	NA
hsa-miR-576-5p	PGR	-1.14232646292515	1.5482527416668e-05	5.0585781178635	1.5277201772991e-24	mirMAP	-1.00854502040787	3.12012785503203e-22		NA	NA	NA
hsa-miR-589-3p	PGR	-1.01260581601727	1.23682952986115e-11	5.0585781178635	1.5277201772991e-24	mirMAP	-0.644485056573719	4.31449107319219e-15		NA	NA	NA
hsa-miR-590-3p	PGR	-1.0148756365213	1.31613112773512e-09	5.0585781178635	1.5277201772991e-24	PITA;mirMAP	-1.11018770410964	3.2826262309391e-29		NA	NA	NA
hsa-miR-9-5p	PGR	-2.25238007294585	0.00288819072983746	5.0585781178635	1.5277201772991e-24	mirMAP	-0.602420512572133	2.76342627979523e-33		NA	NA	NA
hsa-miR-93-5p	PGR	-0.875773165873063	0.346971797039533	5.0585781178635	1.5277201772991e-24	mirMAP	-1.31801911549298	1.83271765558396e-31		NA	NA	NA
hsa-miR-107	SYT9	-0.268297495992237	0.558574531375226	5.0439429727616	8.10659629606326e-44	miRanda	-0.592336548691308	0.000176846521294597		NA	NA	NA
hsa-miR-142-3p	SYT9	-0.991543204185263	0.192118462717103	5.0439429727616	8.10659629606326e-44	miRanda	-0.485458396199416	7.27435783550917e-12		NA	NA	NA
hsa-miR-146b-5p	SYT9	-0.808743278481364	0.235429858527584	5.0439429727616	8.10659629606326e-44	miRanda	-0.888098462618609	1.52831318118446e-15		NA	NA	NA
hsa-miR-192-5p	SYT9	-0.51379465228502	0.412351178690012	5.0439429727616	8.10659629606326e-44	mirMAP	-0.471624190190852	9.87036954315356e-06		NA	NA	NA
hsa-miR-193a-3p	SYT9	-0.204307820042279	0.505705966240602	5.0439429727616	8.10659629606326e-44	miRanda	-0.699515775241176	5.24084665321133e-09		NA	NA	NA
hsa-miR-196b-5p	SYT9	-0.535307526178176	0.340253136317491	5.0439429727616	8.10659629606326e-44	MirTarget	-0.395493908865485	1.64509071000021e-07		NA	NA	NA
hsa-miR-29a-3p	SYT9	-0.401946497419312	0.670926659929692	5.0439429727616	8.10659629606326e-44	miRNATAP	-0.493157807302895	0.000394961993486084		NA	NA	NA
hsa-miR-29b-3p	SYT9	-0.181214222066229	0.790212644347421	5.0439429727616	8.10659629606326e-44	miRNATAP	-0.451252177172674	0.00018001711372706		NA	NA	NA
hsa-miR-30b-3p	SYT9	-0.26345830010187	0.0810383969880402	5.0439429727616	8.10659629606326e-44	MirTarget	-0.468675562554171	7.11992631369479e-06		NA	NA	NA
hsa-miR-320b	SYT9	-0.568525797794295	0.00392831837889986	5.0439429727616	8.10659629606326e-44	miRanda	-0.463416809920917	9.6821930612019e-06		NA	NA	NA
hsa-miR-324-5p	SYT9	-0.857987753799243	0.00796931745099012	5.0439429727616	8.10659629606326e-44	miRanda	-0.853392890563215	4.59307501678964e-21		NA	NA	NA
hsa-miR-326	SYT9	-0.122134738445609	0.638100899425636	5.0439429727616	8.10659629606326e-44	MirTarget;PITA;miRanda;miRNATAP	-0.162149550387017	0.0247626829083362		NA	NA	NA
hsa-miR-330-5p	SYT9	-0.446568912618355	0.21605173591523	5.0439429727616	8.10659629606326e-44	MirTarget;PITA;miRanda;miRNATAP	-0.597836450101949	1.41170640055706e-06		NA	NA	NA
hsa-miR-331-5p	SYT9	-0.357347083004661	0.00753275276575309	5.0439429727616	8.10659629606326e-44	PITA;miRNATAP	-0.566912574174871	8.37409790135952e-06		NA	NA	NA
hsa-miR-374a-5p	SYT9	-0.46017658103009	0.233995386626867	5.0439429727616	8.10659629606326e-44	mirMAP	-0.856238529243804	1.71958349537697e-07		NA	NA	NA
hsa-miR-374b-5p	SYT9	-0.44830162044649	0.30848097286561	5.0439429727616	8.10659629606326e-44	mirMAP	-1.0394838641181	8.97612821886717e-11		NA	NA	NA
hsa-miR-455-5p	SYT9	-1.08026558314669	0.00285665565397908	5.0439429727616	8.10659629606326e-44	miRanda	-0.873414306955424	8.19520974200567e-20		NA	NA	NA
hsa-miR-671-5p	SYT9	-0.698968115908583	7.51812034373903e-05	5.0439429727616	8.10659629606326e-44	MirTarget	-0.799833621349481	4.07398985861183e-16		NA	NA	NA
hsa-miR-9-5p	SYT9	-2.25238007294585	0.00288819072983746	5.0439429727616	8.10659629606326e-44	miRNATAP	-0.523248272260402	3.37311841899627e-23		NA	NA	NA
hsa-miR-326	TFF1	-0.122134738445609	0.638100899425636	7.98331690513044	4.80853153357139e-43	miRanda	-0.307223389114311	0.00258934712955116		NA	NA	NA
hsa-miR-330-5p	TFF1	-0.446568912618355	0.21605173591523	7.98331690513044	4.80853153357139e-43	miRanda	-0.873292788372431	6.14785804388824e-07		NA	NA	NA
hsa-miR-590-3p	TFF1	-1.0148756365213	1.31613112773512e-09	7.98331690513044	4.80853153357139e-43	miRanda	-1.20093974336874	4.49067318867514e-16		NA	NA	NA
hsa-miR-1301-3p	TFF3	-1.12006040812031	1.99899647635817e-05	5.82150403400819	6.68387901963424e-24	MirTarget	-0.630724103782286	1.5285053590182e-11		NA	NA	NA
hsa-miR-320a	TFF3	-0.138884962889948	0.842603295849583	5.82150403400819	6.68387901963424e-24	miRanda	-0.340100176526261	0.0316004336193192		NA	NA	NA
hsa-miR-320b	TFF3	-0.568525797794295	0.00392831837889986	5.82150403400819	6.68387901963424e-24	miRanda	-0.691220912463874	5.78171437983842e-10		NA	NA	NA