miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-5p AIFM1 0.770868211539597 6.63408323707647e-21 -0.728411939702394 5.00458432672625e-10 miRNATAP -0.470682890698395 2.88741688951815e-10 NA NA NA hsa-let-7i-5p AIFM1 0.911372377723717 7.11483853341932e-31 -0.728411939702394 5.00458432672625e-10 miRNATAP -0.494909529869176 4.3632659989207e-11 NA NA NA hsa-miR-155-5p AIFM1 3.26274490570809 5.06841441826518e-51 -0.728411939702394 5.00458432672625e-10 miRNAWalker2_validate -0.137524752987039 7.53302209473207e-08 NA NA NA hsa-miR-20a-3p AIFM1 -0.112128426252791 0.346272219285942 -0.728411939702394 5.00458432672625e-10 miRNATAP -0.145485976932515 0.00944783094549841 NA NA NA hsa-let-7b-3p AKT2 0.239865279324672 0.00721479815526816 -0.340477996057433 3.62402949162022e-08 MirTarget -0.103250394013056 0.00819845290941259 NA NA NA hsa-miR-140-5p AKT2 0.504309496243674 3.09884038729031e-11 -0.340477996057433 3.62402949162022e-08 mirMAP -0.257894167615696 4.25294111137846e-09 NA NA NA hsa-miR-193a-3p AKT2 0.849206638484406 3.68101781083335e-14 -0.340477996057433 3.62402949162022e-08 miRanda -0.1602336102543 4.66296866332011e-08 NA NA NA hsa-miR-1976 AKT2 0.343475600930938 0.000360243844871748 -0.340477996057433 3.62402949162022e-08 miRNATAP -0.114100456416688 0.00148676672535644 NA NA NA hsa-miR-21-5p AKT2 2.51462371613332 3.30620591950316e-66 -0.340477996057433 3.62402949162022e-08 miRNAWalker2_validate -0.116002520060245 7.24256492760299e-10 NA NA NA hsa-miR-2355-5p AKT2 1.57515081110162 3.54962327490702e-48 -0.340477996057433 3.62402949162022e-08 mirMAP -0.158007486287123 5.63512797747714e-09 NA NA NA hsa-miR-24-3p AKT2 0.173813044685099 0.00565259443420961 -0.340477996057433 3.62402949162022e-08 mirMAP -0.145738275793208 0.0095430051404417 NA NA NA hsa-miR-330-5p AKT2 1.44960468659754 2.12131210588035e-45 -0.340477996057433 3.62402949162022e-08 miRanda -0.199850402161812 2.39463482226386e-12 NA NA NA hsa-miR-338-3p AKT2 0.906250377628867 2.76970900371139e-15 -0.340477996057433 3.62402949162022e-08 mirMAP -0.160942202850334 1.55482491354725e-08 NA NA NA hsa-miR-342-3p AKT2 1.4124432570595 1.07208971556131e-28 -0.340477996057433 3.62402949162022e-08 mirMAP -0.193694719446483 5.5338386148732e-16 NA NA NA hsa-miR-423-3p AKT2 0.460506077888547 3.44680149368459e-09 -0.340477996057433 3.62402949162022e-08 miRNAWalker2_validate -0.134093002116074 0.00224236224837297 NA NA NA hsa-miR-106b-5p AKT3 1.07509411417907 2.11739194181878e-36 -0.243988630870274 0.0117503955413685 miRNATAP -0.362551297020254 3.77551886386752e-11 NA NA NA hsa-miR-107 AKT3 0.140046250553248 0.0943611632552367 -0.243988630870274 0.0117503955413685 PITA;miRanda -0.284787420850406 8.53745778311515e-06 NA NA NA hsa-miR-146b-5p AKT3 1.40714170253819 2.9559871816487e-12 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate -0.106480044558668 2.77668665683102e-05 NA NA NA hsa-miR-15a-5p AKT3 1.42663930007845 1.36006952074963e-57 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate;miRTarBase;miRNATAP -0.209553352701426 2.74861510149098e-05 NA NA NA hsa-miR-15b-5p AKT3 0.773001494057531 1.71784656078957e-16 -0.243988630870274 0.0117503955413685 miRNATAP -0.179137071242714 0.00102312999530003 NA NA NA hsa-miR-16-5p AKT3 0.934012514027655 4.85417898318515e-24 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate;miRTarBase;miRNATAP -0.174740148583929 0.00122158424330689 NA NA NA hsa-miR-17-3p AKT3 0.723795600017259 5.90151677164931e-18 -0.243988630870274 0.0117503955413685 miRNATAP -0.202376849787589 0.00088737719875351 NA NA NA hsa-miR-17-5p AKT3 0.494260110870015 3.8348005261e-09 -0.243988630870274 0.0117503955413685 TargetScan;miRNATAP -0.190824149294487 0.00237163147001594 NA NA NA hsa-miR-22-3p AKT3 0.198460552200729 0.00761005672059428 -0.243988630870274 0.0117503955413685 miRNATAP -0.407589872687642 1.12041867452881e-08 NA NA NA hsa-miR-29a-3p AKT3 -0.431613225927952 4.10166815070288e-08 -0.243988630870274 0.0117503955413685 miRNATAP -0.244491422189309 0.000269689815704259 NA NA NA hsa-miR-29b-3p AKT3 -0.228125979913806 0.0271621721891603 -0.243988630870274 0.0117503955413685 miRNATAP -0.247981734385757 1.40066355236384e-06 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-374b-5p AKT3 0.0804104684417872 0.365593963035077 -0.243988630870274 0.0117503955413685 mirMAP -0.250536892298211 3.33662467499594e-05 NA NA NA hsa-miR-421 AKT3 0.313155739887734 0.020433534776003 -0.243988630870274 0.0117503955413685 miRanda;mirMAP -0.144627984206661 0.000385343212972084 NA NA NA hsa-miR-542-3p AKT3 0.431147917094433 0.000254981247606435 -0.243988630870274 0.0117503955413685 miRanda -0.173551255334696 0.000111564350795738 NA NA NA hsa-miR-616-5p AKT3 0.913426384742148 3.78418389333709e-09 -0.243988630870274 0.0117503955413685 mirMAP -0.172749202880246 3.16635692442533e-07 NA NA NA hsa-miR-93-5p AKT3 1.37365940377595 2.37567548683245e-46 -0.243988630870274 0.0117503955413685 miRNATAP -0.172188027294336 0.000349761294454902 NA NA NA hsa-miR-200b-3p APAF1 -1.70383252137161 2.38979336321755e-30 0.435072085538112 7.60618397416958e-11 TargetScan -0.112018363121758 9.6128602239266e-07 NA NA NA hsa-miR-23b-3p APAF1 -0.533749586990474 2.46924776953771e-10 0.435072085538112 7.60618397416958e-11 miRNATAP -0.182869152559669 2.90663696922519e-05 NA NA NA hsa-miR-27b-3p APAF1 -0.699527231242518 1.07356023759234e-15 0.435072085538112 7.60618397416958e-11 miRNATAP -0.318576722265769 1.84303747762354e-15 NA NA NA hsa-miR-429 APAF1 -2.16569233119434 2.66862243626443e-37 0.435072085538112 7.60618397416958e-11 PITA;miRanda;miRNATAP -0.124889354656761 1.03078574481303e-10 NA NA NA hsa-miR-502-3p APAF1 -1.10416310320528 1.55354569985732e-22 0.435072085538112 7.60618397416958e-11 miRNATAP -0.200180201510949 5.50515720295631e-11 NA NA NA hsa-miR-125a-3p ATM -0.372794471295036 0.000941729459601642 0.530797531772122 1.02844462108312e-10 miRanda -0.179965024380568 1.10498221966636e-05 NA NA NA hsa-miR-26b-5p ATM -0.251437253429904 0.00270935785098697 0.530797531772122 1.02844462108312e-10 MirTarget -0.185032803316412 0.000897517946339252 NA NA NA hsa-miR-29a-5p ATM -0.519003718107105 1.03351148282116e-06 0.530797531772122 1.02844462108312e-10 mirMAP -0.153905144304669 0.000365513905294653 NA NA NA hsa-miR-30b-5p ATM -1.18330589477119 6.8341618466966e-27 0.530797531772122 1.02844462108312e-10 mirMAP -0.228607322895133 2.14088060321202e-09 25202329 However specific miRNAs are downregulated in ATC such as those of the miR-200 and miR-30 families which are important negative regulators of cell migration invasion and epithelial-to-mesenchymal transition EMT processes that are overactivated in ATC cell migration thyroid cancer hsa-miR-324-5p ATM -0.487750893426456 3.74472736457965e-05 0.530797531772122 1.02844462108312e-10 miRanda -0.10710960945207 0.00612346545427813 NA NA NA hsa-miR-335-3p ATM -1.36498175550207 6.84287752180534e-13 0.530797531772122 1.02844462108312e-10 mirMAP -0.113210536832474 1.25366052986396e-06 NA NA NA hsa-miR-339-5p ATM 0.322848334531193 0.0117281778821612 0.530797531772122 1.02844462108312e-10 miRanda -0.101879382550005 0.00505045529852259 NA NA NA hsa-miR-362-3p ATM -0.753214251798232 3.0025661608035e-07 0.530797531772122 1.02844462108312e-10 miRanda -0.108774551175696 0.000687826877699034 NA NA NA hsa-miR-30a-5p BAX -0.778411951775343 2.73322451127932e-16 1.2440285662486 5.10229836008695e-44 miRNAWalker2_validate -0.441807083919337 6.33672516394284e-16 NA NA NA hsa-miR-125b-5p BCL2 -0.825456421494266 2.13029877878434e-15 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate;miRTarBase -0.18771702327675 0.000938494359228133 24643683;21823019;20460378;26744308 Moreover we demonstrated that the pro-apoptotic Bcl-2 antagonist killer 1 Bak1 was a direct target of miR-125b;miR 125b confers resistance of ovarian cancer cells to cisplatin by targeting pro apoptotic Bcl 2 antagonist killer 1;Moreover we demonstrated that the pro-apoptotic Bcl-2 antagonist killer 1 Bak1 is a direct target of miR-125b;Our data also verified that Bcl-2 is the target of miR-125b; Meanwhile we showed that Bcl-2 was inversely correlated with miR-125b in osteosarcoma tissues; More importantly we proved that miR-125b increased the chemosensitivity of osteosarcoma cell lines to cisplatin by targeting Bcl-2 ;drug resistance;; glioblastoma;ovarian cancer;breast cancer;sarcoma hsa-miR-136-5p BCL2 -1.67696564080585 1.99625416234538e-18 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate;miRTarBase -0.146439820440682 1.14288049875745e-06 NA NA NA hsa-miR-182-5p BCL2 -0.608710746044567 0.0025264935278104 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate;miRTarBase;mirMAP -0.177081265177555 2.6443917985073e-09 23936432;26870290 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR 182 and p21; Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells;The expression levels of B-cell lymphoma-2 Bcl-2 and microRNA-182 miR-182 were detected using western blot analysis and quantitative reverse transcription-polymerase chain reaction respectively; Mangiferin treatment was also able to significantly reduce Bcl-2 expression levels and enhance miR-182 expression in PC3 cells; Finally it was observed that mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182 ; prostate cancer;B cell lymphoma hsa-miR-29a-3p BCL2 -0.431613225927952 4.10166815070288e-08 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate;miRTarBase -0.567223045416415 3.24510575317255e-14 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29a-5p BCL2 -0.519003718107105 1.03351148282116e-06 0.611723089464483 2.23843978894366e-08 mirMAP -0.259237667771286 4.98631789999366e-06 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29b-3p BCL2 -0.228125979913806 0.0271621721891603 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate;miRTarBase -0.330351798843962 1.96048711047023e-08 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-335-3p BCL2 -1.36498175550207 6.84287752180534e-13 0.611723089464483 2.23843978894366e-08 mirMAP -0.215422651970675 1.11346348504947e-12 NA NA NA hsa-miR-33a-5p BCL2 -1.59840463890997 1.13487952314403e-18 0.611723089464483 2.23843978894366e-08 mirMAP -0.157287327649195 8.12118407365628e-07 NA NA NA hsa-miR-365a-3p BCL2 0.80809616164259 2.36039522526e-12 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate;miRTarBase -0.227996300541644 8.90997818574674e-06 NA NA NA hsa-miR-375 BCL2 -1.46468479447701 9.20596529469647e-07 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate -0.102079936703486 3.24244153934503e-07 26381132;26697569;25613180 The levels of miR-375 Bax and Bcl-2 protein expression in treated cells were determined by Western blot and RT-PCR; Moreover compared to control group the expression of Bcl-2 and miR-375 decreases with formononetin in the U2OS cells while Bax increases;Exosome Carried microRNA 375 Inhibits Cell Progression and Dissemination via Bcl 2 Blocking in Colon Cancer; RT-PCR for Bcl-2 expression showed that Bcl-2 is down-regulated for miR-375 inhibitor and up-regulated for the miR-375 mimic a result confirmed by Western blotting; The present study brings to the forefront new data that suggest miR-375 as a new player in controlling the pathways responsible for inhibiting the natural history of CRC tumor cells via the Bcl-2 pathway;mRNA levels of ERα Bcl-2 and miR-375 were quantified using real-time polymerase chain reaction; After treatment with biochanin A ERα miR-375 and Bcl-2 expression was significantly upregulated ;progression; sarcoma;colon cancer;breast cancer hsa-miR-409-3p BCL2 -0.292481246887274 0.114186058216271 0.611723089464483 2.23843978894366e-08 mirMAP -0.139981660731413 2.67838476038654e-05 NA NA NA hsa-miR-582-5p BCL2 -0.323404837478908 0.0786820871592677 0.611723089464483 2.23843978894366e-08 PITA -0.140583753589503 2.48245800619386e-05 NA NA NA hsa-miR-96-5p BCL2 -1.00223771166604 3.91564621567028e-06 0.611723089464483 2.23843978894366e-08 miRNAWalker2_validate;TargetScan -0.189419757848449 1.35177733054416e-11 NA NA NA hsa-miR-505-5p BCL2L1 -0.109332726329313 0.346400159841743 0.056672670469081 0.380838191246795 miRNATAP -0.108957481398792 0.000366888756795515 NA NA NA hsa-miR-149-5p BID -1.95790336710741 8.46371715052367e-27 1.35299914873585 2.44298152501925e-47 miRNAWalker2_validate -0.158990823438723 8.98065416834074e-08 NA NA NA hsa-miR-199a-5p BID -1.64658415208633 1.01615659358973e-23 1.35299914873585 2.44298152501925e-47 miRanda -0.156654911436654 3.1360644682194e-06 NA NA NA hsa-miR-29a-3p BIRC2 -0.431613225927952 4.10166815070288e-08 0.0936851144208237 0.0807862381939828 MirTarget -0.170009571948633 3.51674867601628e-06 NA NA NA hsa-miR-24-1-5p BIRC3 -1.09236439756236 3.27091225010919e-23 2.16852582874657 2.6183978984711e-35 MirTarget -0.68766850209417 5.40643873929542e-15 NA NA NA hsa-miR-362-3p BIRC3 -0.753214251798232 3.0025661608035e-07 2.16852582874657 2.6183978984711e-35 miRanda -0.304997029758662 3.69089818905335e-05 NA NA NA hsa-miR-577 BIRC3 -1.48881999472397 7.03080165111147e-10 2.16852582874657 2.6183978984711e-35 MirTarget -0.206690967592039 1.67142500868513e-06 NA NA NA hsa-miR-140-5p CAPN1 0.504309496243674 3.09884038729031e-11 -0.285632443227867 2.71856226421335e-05 miRanda;miRNATAP -0.215728735948683 8.56153810827839e-06 NA NA NA hsa-miR-101-3p CAPN2 0.683973909682285 2.88573524246948e-15 -0.762469388700106 2.42642475927298e-37 miRNAWalker2_validate;MirTarget -0.239214488941535 2.77066368952869e-09 NA NA NA hsa-miR-16-2-3p CAPN2 1.3046118743965 4.17207934608428e-19 -0.762469388700106 2.42642475927298e-37 mirMAP -0.14422324354442 6.2735592904303e-10 NA NA NA hsa-miR-320a CAPN2 0.412740558379182 2.02929519701706e-05 -0.762469388700106 2.42642475927298e-37 miRanda -0.178441604937035 1.94035971688438e-06 NA NA NA hsa-miR-590-3p CAPN2 1.13702599385212 3.53435739887793e-22 -0.762469388700106 2.42642475927298e-37 miRanda -0.183748578938975 1.71061025216289e-10 NA NA NA hsa-miR-590-5p CAPN2 0.709763558412506 1.11883921359361e-11 -0.762469388700106 2.42642475927298e-37 miRanda -0.147682412734985 1.44850809394642e-05 NA NA NA hsa-miR-30b-3p CASP10 -1.64703050862226 1.89878531036464e-31 0.158715251481416 0.0167089895093769 MirTarget -0.104118695907044 8.65292407685975e-06 NA NA NA hsa-miR-532-5p CASP10 -1.09700348358668 8.34836230254408e-26 0.158715251481416 0.0167089895093769 mirMAP -0.11023000449071 0.00065064030081201 NA NA NA hsa-let-7c-5p CASP3 -0.293028324454433 0.00593011890352725 0.624242394440305 5.90002612682267e-19 MirTarget -0.150491988361227 8.20207927774945e-05 NA NA NA hsa-miR-139-5p CASP3 -0.704802495091118 2.36904108453776e-06 0.624242394440305 5.90002612682267e-19 miRanda -0.150517905192826 1.32408198037557e-08 NA NA NA hsa-miR-26b-5p CASP3 -0.251437253429904 0.00270935785098697 0.624242394440305 5.90002612682267e-19 miRNAWalker2_validate -0.127148355034747 0.00957021650716659 NA NA NA hsa-miR-30a-5p CASP3 -0.778411951775343 2.73322451127932e-16 0.624242394440305 5.90002612682267e-19 miRNATAP -0.345510630044846 9.70443157697282e-19 NA NA NA hsa-miR-30c-5p CASP3 -1.08783070774238 2.02505402525786e-24 0.624242394440305 5.90002612682267e-19 miRNATAP -0.225556550786425 8.74333982362343e-11 NA NA NA hsa-miR-30d-5p CASP3 -0.202727675788184 0.00659067084745794 0.624242394440305 5.90002612682267e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.283929971801396 1.94904159154662e-07 NA NA NA hsa-miR-125a-5p CASP6 -0.561874059994802 7.3931856356891e-13 -0.0276081385790365 0.628167212156878 miRanda -0.149593981000182 0.00010728482022913 NA NA NA hsa-miR-361-5p CASP7 0.0514169367202078 0.382929376393199 -0.0884427750956416 0.14345248230666 PITA;miRanda -0.176721370383696 0.00220871236992667 NA NA NA hsa-miR-126-5p CASP9 0.785607261431085 5.77058629454465e-13 -0.640493643795454 4.84619402433504e-23 MirTarget -0.209827969339424 2.33512843630455e-10 NA NA NA hsa-miR-130b-5p CASP9 0.92990617673277 3.75880436852717e-12 -0.640493643795454 4.84619402433504e-23 mirMAP -0.133542104018384 1.00105836546299e-06 NA NA NA hsa-miR-140-5p CASP9 0.504309496243674 3.09884038729031e-11 -0.640493643795454 4.84619402433504e-23 miRanda -0.223105511125259 5.15163770332575e-06 NA NA NA hsa-miR-15a-5p CASP9 1.42663930007845 1.36006952074963e-57 -0.640493643795454 4.84619402433504e-23 mirMAP -0.233625908587689 2.44769264872863e-11 NA NA NA hsa-miR-15b-5p CASP9 0.773001494057531 1.71784656078957e-16 -0.640493643795454 4.84619402433504e-23 mirMAP -0.134379770025843 0.00056125692133512 NA NA NA hsa-miR-16-5p CASP9 0.934012514027655 4.85417898318515e-24 -0.640493643795454 4.84619402433504e-23 mirMAP -0.248606565461915 4.07153687129857e-11 NA NA NA hsa-miR-17-5p CASP9 0.494260110870015 3.8348005261e-09 -0.640493643795454 4.84619402433504e-23 TargetScan -0.125797566438446 0.00510774359125448 NA NA NA hsa-miR-186-5p CASP9 0.507217561043443 9.04455748270995e-10 -0.640493643795454 4.84619402433504e-23 mirMAP -0.146721856991177 0.00121342804051267 NA NA NA hsa-miR-342-5p CASP9 1.37011183051517 4.99462376051624e-28 -0.640493643795454 4.84619402433504e-23 MirTarget -0.152515106474698 3.45836685797776e-08 NA NA NA hsa-miR-590-3p CASP9 1.13702599385212 3.53435739887793e-22 -0.640493643795454 4.84619402433504e-23 miRanda -0.159671085910094 1.12473604347217e-07 NA NA NA hsa-miR-125a-5p CFLAR -0.561874059994802 7.3931856356891e-13 0.365456941720936 8.27767685055272e-08 miRanda -0.213783821990456 5.6702590237705e-06 NA NA NA hsa-miR-130a-3p CFLAR -0.667386596699886 1.34029167767774e-10 0.365456941720936 8.27767685055272e-08 mirMAP -0.206971026359822 4.01185111403959e-09 NA NA NA hsa-miR-199a-5p CFLAR -1.64658415208633 1.01615659358973e-23 0.365456941720936 8.27767685055272e-08 mirMAP -0.104899151638695 9.39006726505628e-07 NA NA NA hsa-miR-26a-5p CFLAR -0.202091714279613 0.00166918288801054 0.365456941720936 8.27767685055272e-08 miRNAWalker2_validate -0.202948679918865 0.000745001212307381 NA NA NA hsa-miR-30b-3p CFLAR -1.64703050862226 1.89878531036464e-31 0.365456941720936 8.27767685055272e-08 mirMAP -0.179128676898025 5.48433718808998e-14 NA NA NA hsa-miR-106b-5p CHP2 1.07509411417907 2.11739194181878e-36 -4.85824590499015 3.05626798767572e-58 MirTarget -1.58995368270032 4.17510489844563e-15 NA NA NA hsa-miR-17-5p CHP2 0.494260110870015 3.8348005261e-09 -4.85824590499015 3.05626798767572e-58 MirTarget -1.05293982395628 6.26552263101198e-06 NA NA NA hsa-miR-20a-5p CHP2 0.702602695798242 4.06372887613329e-13 -4.85824590499015 3.05626798767572e-58 MirTarget -1.26631554399921 8.83278262712219e-11 NA NA NA hsa-miR-224-5p CHP2 2.84654230414912 3.0480927226395e-47 -4.85824590499015 3.05626798767572e-58 MirTarget -0.806037485399145 6.26769397013649e-23 NA NA NA hsa-miR-320a CHP2 0.412740558379182 2.02929519701706e-05 -4.85824590499015 3.05626798767572e-58 miRanda -0.731704395825421 0.000358100930886103 NA NA NA hsa-miR-93-5p CHP2 1.37365940377595 2.37567548683245e-46 -4.85824590499015 3.05626798767572e-58 MirTarget -1.74045083301575 3.782182814463e-25 NA NA NA hsa-miR-126-5p CHUK 0.785607261431085 5.77058629454465e-13 -0.85746072421144 8.10744991906236e-38 MirTarget;mirMAP;miRNATAP -0.141478846302423 0.000105653732136013 NA NA NA hsa-miR-15a-5p CHUK 1.42663930007845 1.36006952074963e-57 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;miRTarBase;MirTarget -0.318418636879753 7.69752994687939e-18 NA NA NA hsa-miR-15b-5p CHUK 0.773001494057531 1.71784656078957e-16 -0.85746072421144 8.10744991906236e-38 MirTarget -0.225889800417735 5.44303807977529e-08 NA NA NA hsa-miR-16-5p CHUK 0.934012514027655 4.85417898318515e-24 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;miRTarBase;MirTarget -0.228889855351981 2.57589362388376e-08 NA NA NA hsa-miR-195-5p CHUK 0.346502644882604 0.0092562828415903 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;MirTarget -0.157478463247597 2.5847715765755e-07 NA NA NA hsa-miR-223-3p CHUK 1.23291409735619 1.07767240442694e-17 -0.85746072421144 8.10744991906236e-38 miRNAWalker2_validate;miRTarBase -0.158778742351017 2.71041182397134e-09 NA NA NA hsa-miR-23a-3p CHUK 0.761438723382355 4.09310879199257e-27 -0.85746072421144 8.10744991906236e-38 MirTarget -0.426829131699392 2.80265744990605e-16 NA NA NA hsa-miR-342-3p CHUK 1.4124432570595 1.07208971556131e-28 -0.85746072421144 8.10744991906236e-38 miRanda -0.194422482412743 1.9269792265026e-11 NA NA NA hsa-miR-497-5p CHUK 0.227757383708836 0.0600073987853074 -0.85746072421144 8.10744991906236e-38 MirTarget -0.149867793994567 9.91621768564792e-06 NA NA NA hsa-miR-590-3p CHUK 1.13702599385212 3.53435739887793e-22 -0.85746072421144 8.10744991906236e-38 miRanda;mirMAP -0.204551923277616 2.23702640558868e-10 NA NA NA hsa-miR-590-5p CHUK 0.709763558412506 1.11883921359361e-11 -0.85746072421144 8.10744991906236e-38 miRanda -0.177887016696357 2.94637831990317e-06 NA NA NA hsa-miR-125a-5p CSF2RB -0.561874059994802 7.3931856356891e-13 1.53131879126979 1.05288331370998e-31 miRanda -0.614243689240012 2.13235884305686e-10 NA NA NA hsa-miR-30b-3p CSF2RB -1.64703050862226 1.89878531036464e-31 1.53131879126979 1.05288331370998e-31 MirTarget -0.459985158783373 2.07886560326231e-21 NA NA NA hsa-miR-532-5p CSF2RB -1.09700348358668 8.34836230254408e-26 1.53131879126979 1.05288331370998e-31 MirTarget -0.59475160408329 7.07128968939799e-19 NA NA NA hsa-miR-106b-5p CYCS 1.07509411417907 2.11739194181878e-36 -0.969835367128812 3.06937589631637e-21 mirMAP -0.388248317525564 3.83628198093126e-10 NA NA NA hsa-miR-140-5p CYCS 0.504309496243674 3.09884038729031e-11 -0.969835367128812 3.06937589631637e-21 miRanda -0.477930167294307 3.37625527063031e-10 NA NA NA hsa-miR-16-5p CYCS 0.934012514027655 4.85417898318515e-24 -0.969835367128812 3.06937589631637e-21 miRNAWalker2_validate -0.261301613119267 1.5822565057047e-05 NA NA NA hsa-miR-186-5p CYCS 0.507217561043443 9.04455748270995e-10 -0.969835367128812 3.06937589631637e-21 mirMAP -0.202452611335779 0.00471920190357848 NA NA NA hsa-miR-18a-5p CYCS 0.936704393213466 1.05064580570579e-10 -0.969835367128812 3.06937589631637e-21 mirMAP -0.147860218253007 0.000237877687365353 NA NA NA hsa-miR-20a-5p CYCS 0.702602695798242 4.06372887613329e-13 -0.969835367128812 3.06937589631637e-21 mirMAP -0.224953584305875 0.000179434795436189 NA NA NA hsa-miR-21-3p CYCS 1.78837590049697 1.41655409877312e-33 -0.969835367128812 3.06937589631637e-21 mirMAP -0.232549011414093 7.41130855805383e-11 18798260 In addition flow cytometry analysis of JHU-012 cells 48 hr after mir-21 inhibitor transfection showed a statistically significant increase in cytochrome c release and increased apoptosis head and neck cancer hsa-miR-342-3p CYCS 1.4124432570595 1.07208971556131e-28 -0.969835367128812 3.06937589631637e-21 mirMAP -0.251205445834589 3.65565715108996e-09 NA NA NA hsa-miR-576-5p CYCS 1.06681109513983 5.69294424466526e-24 -0.969835367128812 3.06937589631637e-21 mirMAP -0.264733598044829 4.65620883700611e-07 NA NA NA hsa-miR-93-3p CYCS 0.379664250785728 9.76327751780657e-05 -0.969835367128812 3.06937589631637e-21 miRNAWalker2_validate -0.225352486946618 0.000244687782888765 NA NA NA hsa-miR-93-5p CYCS 1.37365940377595 2.37567548683245e-46 -0.969835367128812 3.06937589631637e-21 mirMAP -0.336147560951057 2.58720920953014e-10 NA NA NA hsa-let-7b-5p DFFA 0.770868211539597 6.63408323707647e-21 -0.556572810839827 1.86310213012181e-28 miRNAWalker2_validate -0.163523682068137 1.91834832503954e-06 NA NA NA hsa-miR-155-5p DFFA 3.26274490570809 5.06841441826518e-51 -0.556572810839827 1.86310213012181e-28 mirMAP -0.111661822811556 2.79388156161288e-24 NA NA NA hsa-miR-16-1-3p DFFA 1.51429140700091 3.17219833254498e-37 -0.556572810839827 1.86310213012181e-28 mirMAP -0.150153436295346 1.74466551409029e-11 NA NA NA hsa-miR-193a-5p DFFA 1.29777740059595 2.16815694068336e-39 -0.556572810839827 1.86310213012181e-28 TargetScan -0.234216724183675 4.90433979908784e-20 NA NA NA hsa-miR-196a-5p DFFA 0.440858887700369 2.0077143292463e-05 -0.556572810839827 1.86310213012181e-28 miRNAWalker2_validate -0.107415168634886 0.000194355996915052 NA NA NA hsa-miR-21-5p DFFA 2.51462371613332 3.30620591950316e-66 -0.556572810839827 1.86310213012181e-28 mirMAP -0.170651722646623 1.1853596918748e-28 NA NA NA hsa-miR-320a DFFA 0.412740558379182 2.02929519701706e-05 -0.556572810839827 1.86310213012181e-28 miRanda -0.127534645562436 3.33101150370106e-05 NA NA NA hsa-miR-342-3p DFFA 1.4124432570595 1.07208971556131e-28 -0.556572810839827 1.86310213012181e-28 mirMAP -0.153815457512834 2.25887474180834e-13 NA NA NA hsa-miR-374a-3p DFFA 1.13863935833993 2.79089304015401e-44 -0.556572810839827 1.86310213012181e-28 mirMAP -0.24338151064614 5.14357932883517e-15 NA NA NA hsa-miR-374a-5p DFFA 0.543061152108237 2.19403097299769e-14 -0.556572810839827 1.86310213012181e-28 mirMAP -0.18675994300009 4.80335704402944e-06 NA NA NA hsa-miR-590-5p DFFA 0.709763558412506 1.11883921359361e-11 -0.556572810839827 1.86310213012181e-28 miRanda;mirMAP -0.127970988212764 3.99834963365463e-06 NA NA NA hsa-miR-30b-3p DFFB -1.64703050862226 1.89878531036464e-31 0.275344779456576 0.00106322365243729 MirTarget -0.142287365176977 1.78531513451151e-06 NA NA NA hsa-miR-193a-3p ENDOD1 0.849206638484406 3.68101781083335e-14 0.0269333423022404 0.742979833307928 miRanda -0.122608570982982 0.00155803021983033 NA NA NA hsa-miR-19a-3p ENDOD1 0.722913586880779 2.76301458932381e-10 0.0269333423022404 0.742979833307928 mirMAP -0.128273602822441 0.000819223759342539 NA NA NA hsa-miR-19b-3p ENDOD1 0.195940928879427 0.0300512922542325 0.0269333423022404 0.742979833307928 mirMAP -0.229584197474086 3.98903306695841e-06 NA NA NA hsa-miR-3613-5p ENDOD1 1.6648190889407 3.78720979041391e-41 0.0269333423022404 0.742979833307928 MirTarget -0.100670787784895 0.00177496011101701 NA NA NA hsa-miR-590-3p ENDOD1 1.13702599385212 3.53435739887793e-22 0.0269333423022404 0.742979833307928 miRanda -0.117187313484179 0.0011293711782308 NA NA NA hsa-miR-106a-5p FAS -0.830908656792615 2.67547872901508e-10 1.2781702198996 1.39159398357076e-35 miRNAWalker2_validate;miRTarBase -0.17563422723919 0.000166805410564044 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-23b-3p FAS -0.533749586990474 2.46924776953771e-10 1.2781702198996 1.39159398357076e-35 miRNATAP -0.365469144431479 5.00602609064883e-07 24356489 Moreover over-expression of Fas rescued the pro-proliferation effect of miR-23 indicating Fas is a direct mediator of miR-23 functions; Furthermore contrast to miR-23a/b which was up regulated the Fas expression level was down-regulated and inversely correlated with miR-23 in split radiation induced lymphoma tissue samples; Finally our data also indicates that miR-23a could repress Fas much more potent than miR-23b and the additional region besides conserved seed pairing enables miR-23a's higher regulation lymphoma hsa-let-7e-5p FASLG -0.727009689927955 1.30690859412163e-11 3.49526870659822 3.0591043026913e-47 miRNATAP -0.956759956622149 2.07254587441987e-12 NA NA NA hsa-let-7g-5p FASLG -0.739744008507763 1.07979566264383e-14 3.49526870659822 3.0591043026913e-47 miRNATAP -0.527566684352497 0.00071592111786537 NA NA NA hsa-miR-199a-5p FASLG -1.64658415208633 1.01615659358973e-23 3.49526870659822 3.0591043026913e-47 miRanda -0.587327373538791 5.90733830602172e-12 NA NA NA hsa-miR-362-3p FASLG -0.753214251798232 3.0025661608035e-07 3.49526870659822 3.0591043026913e-47 miRanda -0.346233134453532 0.00119742349456323 NA NA NA hsa-miR-125a-5p IKBKG -0.561874059994802 7.3931856356891e-13 0.49642799282577 6.30392568162462e-12 miRanda -0.278136800860417 3.13020186123498e-08 NA NA NA hsa-miR-30d-3p IL1B -0.249777194282131 0.00235356711813496 0.452671620711598 0.021616046645869 MirTarget -0.351984998077896 0.0084154714072512 NA NA NA hsa-miR-17-3p IL1R1 0.723795600017259 5.90151677164931e-18 -0.474344231843599 4.16095974966973e-06 mirMAP -0.29448640551499 6.02783377610477e-06 NA NA NA hsa-miR-181a-5p IL1R1 1.11111114875339 3.97880443756442e-29 -0.474344231843599 4.16095974966973e-06 mirMAP -0.181663741757188 0.000629221572221257 NA NA NA hsa-miR-181b-5p IL1R1 1.49054296272357 3.69051660739368e-41 -0.474344231843599 4.16095974966973e-06 mirMAP -0.146779912464916 0.00130558816294013 NA NA NA hsa-miR-30a-3p IL1R1 -0.955360819934585 1.97009535429185e-20 -0.474344231843599 4.16095974966973e-06 mirMAP -0.203431063888192 0.000104910058488366 NA NA NA hsa-miR-30d-3p IL1R1 -0.249777194282131 0.00235356711813496 -0.474344231843599 4.16095974966973e-06 mirMAP -0.291676436549261 3.11895527929566e-05 NA NA NA hsa-miR-30e-3p IL1R1 -0.205602546270795 0.00132666419729688 -0.474344231843599 4.16095974966973e-06 mirMAP -0.321019827583332 0.000415299430775297 NA NA NA hsa-miR-190a-5p IL1RAP -0.286268924946003 0.017120414883133 0.993146308370594 2.45736270922821e-12 MirTarget -0.265039370421194 7.8430540308812e-05 NA NA NA hsa-miR-204-5p IL1RAP -1.67490789640238 9.14741888352476e-10 0.993146308370594 2.45736270922821e-12 miRNAWalker2_validate -0.172111612670959 9.49303301335486e-10 NA NA NA hsa-miR-20b-5p IL1RAP -1.30218163823367 6.87172815978149e-17 0.993146308370594 2.45736270922821e-12 MirTarget -0.213291800752897 1.38048698862176e-05 NA NA NA hsa-miR-29a-3p IL1RAP -0.431613225927952 4.10166815070288e-08 0.993146308370594 2.45736270922821e-12 MirTarget;miRNATAP -0.37571597841406 0.000216941340891102 NA NA NA hsa-miR-29c-3p IL1RAP -0.238671318446745 0.0141475322347596 0.993146308370594 2.45736270922821e-12 MirTarget;miRNATAP -0.382206631616436 3.86355411109542e-06 NA NA NA hsa-miR-362-3p IL1RAP -0.753214251798232 3.0025661608035e-07 0.993146308370594 2.45736270922821e-12 miRanda -0.43019685082498 9.32557861728477e-16 NA NA NA hsa-miR-577 IL1RAP -1.48881999472397 7.03080165111147e-10 0.993146308370594 2.45736270922821e-12 mirMAP -0.13686768995587 2.58299908864779e-05 NA NA NA hsa-miR-362-3p IL3RA -0.753214251798232 3.0025661608035e-07 1.61131969334758 1.96984916616799e-32 miRanda -0.289330502310158 3.01527391899967e-07 NA NA NA hsa-miR-141-3p IRAK3 -5.87110686537457 1.20877726722907e-85 0.779672986292416 6.93609244782046e-11 mirMAP -0.129541967063884 1.23563200311832e-14 NA NA NA hsa-miR-188-5p IRAK3 -1.74586655806628 1.50431624674552e-28 0.779672986292416 6.93609244782046e-11 mirMAP -0.26680688484256 1.5640014514751e-11 NA NA NA hsa-miR-200a-3p IRAK3 -1.43409013664263 2.00188483717828e-20 0.779672986292416 6.93609244782046e-11 mirMAP -0.195104956747173 1.70815447814723e-06 NA NA NA hsa-miR-33a-5p IRAK3 -1.59840463890997 1.13487952314403e-18 0.779672986292416 6.93609244782046e-11 mirMAP -0.180893286188133 2.55277675864723e-07 NA NA NA hsa-miR-363-3p IRAK3 -1.93551166555337 4.45368477487614e-32 0.779672986292416 6.93609244782046e-11 mirMAP -0.11437891345674 0.0022481398647882 NA NA NA hsa-miR-429 IRAK3 -2.16569233119434 2.66862243626443e-37 0.779672986292416 6.93609244782046e-11 miRanda -0.203235023068338 5.67782958045901e-09 NA NA NA hsa-miR-501-5p IRAK3 -1.1103073934745 1.81589804886553e-16 0.779672986292416 6.93609244782046e-11 mirMAP -0.209150291529484 1.12613990293387e-05 NA NA NA hsa-miR-577 IRAK3 -1.48881999472397 7.03080165111147e-10 0.779672986292416 6.93609244782046e-11 mirMAP -0.14117026308953 1.87469056144128e-07 NA NA NA hsa-miR-660-5p IRAK3 -1.20833564582661 8.48975910642834e-23 0.779672986292416 6.93609244782046e-11 mirMAP -0.211082059231021 3.85731892894199e-05 NA NA NA hsa-miR-30a-3p IRAK4 -0.955360819934585 1.97009535429185e-20 0.158359329874843 0.00218781588187908 mirMAP -0.120415054593869 2.98039070299743e-06 NA NA NA hsa-miR-30d-3p IRAK4 -0.249777194282131 0.00235356711813496 0.158359329874843 0.00218781588187908 mirMAP -0.131292677747642 0.000153006670026958 NA NA NA hsa-miR-106a-5p MAP3K14 -0.830908656792615 2.67547872901508e-10 1.45318720445739 1.17584767098145e-30 MirTarget -0.260935740592544 3.40016905381867e-06 NA NA NA hsa-miR-20b-5p MAP3K14 -1.30218163823367 6.87172815978149e-17 1.45318720445739 1.17584767098145e-30 MirTarget -0.279425559529384 1.05548734889612e-09 NA NA NA hsa-miR-345-5p MAP3K14 -0.953479075875024 8.95459389953487e-14 1.45318720445739 1.17584767098145e-30 MirTarget -0.245817055552042 1.76279569036036e-05 NA NA NA hsa-miR-362-3p MAP3K14 -0.753214251798232 3.0025661608035e-07 1.45318720445739 1.17584767098145e-30 miRanda -0.169925700987714 0.00129039879476894 NA NA NA hsa-miR-429 MAP3K14 -2.16569233119434 2.66862243626443e-37 1.45318720445739 1.17584767098145e-30 miRNATAP -0.225255564123646 1.08811226987523e-08 NA NA NA hsa-miR-874-3p MAP3K14 -1.50243370621573 8.39418307315909e-25 1.45318720445739 1.17584767098145e-30 MirTarget -0.489327006006763 7.56144334910118e-28 NA NA NA hsa-miR-429 MYD88 -2.16569233119434 2.66862243626443e-37 0.468611698657308 6.27629991839536e-10 miRanda -0.122542396206778 2.71717304001423e-08 NA NA NA hsa-miR-660-5p MYD88 -1.20833564582661 8.48975910642834e-23 0.468611698657308 6.27629991839536e-10 MirTarget -0.180300559273538 1.7030624387003e-08 NA NA NA hsa-miR-335-5p NFKBIA -2.09515619961552 1.03765771499548e-25 0.620774465078764 3.94529387660432e-13 miRNAWalker2_validate -0.141349234962223 2.11282182163608e-10 NA NA NA hsa-let-7g-5p NGF -0.739744008507763 1.07979566264383e-14 1.68176218451818 4.25883926715749e-21 MirTarget -0.604104636667389 5.7443559092026e-09 NA NA NA hsa-miR-429 NGF -2.16569233119434 2.66862243626443e-37 1.68176218451818 4.25883926715749e-21 miRanda -0.274846404242145 4.10102515693054e-07 NA NA NA hsa-miR-16-1-3p NTRK1 1.51429140700091 3.17219833254498e-37 -2.16917617916044 3.29741000934657e-22 mirMAP -0.547850527770562 3.2373436730389e-08 NA NA NA hsa-miR-185-3p NTRK1 0.993379985307475 2.62011454953707e-13 -2.16917617916044 3.29741000934657e-22 MirTarget -0.306701824990764 0.00125082909655452 NA NA NA hsa-let-7f-1-3p PIK3CA 0.477913872379336 4.46669616865068e-05 -0.342309377518198 0.000115361959187206 mirMAP -0.117169302105272 0.00980511224865979 NA NA NA hsa-miR-148a-5p PIK3CA 0.415500302855613 0.000691460831436767 -0.342309377518198 0.000115361959187206 mirMAP -0.127137756769153 0.00150846590255829 NA NA NA hsa-miR-320b PIK3CA 0.300497419754843 0.0245219177384172 -0.342309377518198 0.000115361959187206 miRanda -0.109684919459557 0.00295331979925903 NA NA NA hsa-miR-339-5p PIK3CA 0.322848334531193 0.0117281778821612 -0.342309377518198 0.000115361959187206 miRanda -0.156390103299638 4.31357238138231e-05 NA NA NA hsa-miR-590-3p PIK3CA 1.13702599385212 3.53435739887793e-22 -0.342309377518198 0.000115361959187206 miRanda;mirMAP -0.167970910292111 1.76355187639927e-05 NA NA NA hsa-miR-590-5p PIK3CA 0.709763558412506 1.11883921359361e-11 -0.342309377518198 0.000115361959187206 miRanda -0.179027916238388 8.77558290901021e-05 NA NA NA hsa-miR-130b-3p PIK3CB 1.12788913578446 2.939369462276e-16 -0.247995112719303 0.00148503458375338 miRNATAP -0.166034631736904 1.58184303321712e-08 NA NA NA hsa-miR-19a-3p PIK3CB 0.722913586880779 2.76301458932381e-10 -0.247995112719303 0.00148503458375338 miRNATAP -0.138948641019506 0.000146950619817948 NA NA NA hsa-miR-19b-3p PIK3CB 0.195940928879427 0.0300512922542325 -0.247995112719303 0.00148503458375338 miRNATAP -0.155249167038679 0.00123255333914152 NA NA NA hsa-miR-25-3p PIK3CB 1.12016166564779 3.79069348635778e-48 -0.247995112719303 0.00148503458375338 miRNATAP -0.168848015389201 0.000511445370430535 NA NA NA hsa-miR-590-3p PIK3CB 1.13702599385212 3.53435739887793e-22 -0.247995112719303 0.00148503458375338 miRNATAP -0.152204162601648 8.6055969781532e-06 NA NA NA hsa-miR-92b-3p PIK3CB 0.418630595140165 6.50466149211154e-05 -0.247995112719303 0.00148503458375338 miRNATAP -0.132204554754912 0.00123182058684873 NA NA NA hsa-miR-10b-5p PIK3CD -0.89971464210447 1.18190532299934e-20 0.827862115800704 6.93199253004924e-19 miRNAWalker2_validate -0.322882758324939 5.32986923354336e-10 NA NA NA hsa-miR-1468-5p PIK3CD -0.311126383179539 0.00979113361106863 0.827862115800704 6.93199253004924e-19 MirTarget -0.200155097962759 8.08016260976088e-06 NA NA NA hsa-miR-30a-5p PIK3CD -0.778411951775343 2.73322451127932e-16 0.827862115800704 6.93199253004924e-19 miRNAWalker2_validate;MirTarget;miRNATAP -0.206007694378125 0.000161176631172019 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30b-3p PIK3CD -1.64703050862226 1.89878531036464e-31 0.827862115800704 6.93199253004924e-19 MirTarget -0.256459682857462 3.84122966933957e-14 NA NA NA hsa-miR-30b-5p PIK3CD -1.18330589477119 6.8341618466966e-27 0.827862115800704 6.93199253004924e-19 MirTarget -0.212463225121162 2.43792629370427e-06 NA NA NA hsa-miR-30c-5p PIK3CD -1.08783070774238 2.02505402525786e-24 0.827862115800704 6.93199253004924e-19 MirTarget;miRNATAP -0.191697315876392 4.85249073283528e-05 NA NA NA hsa-miR-30d-5p PIK3CD -0.202727675788184 0.00659067084745794 0.827862115800704 6.93199253004924e-19 MirTarget;miRNATAP -0.209303428523125 0.00450077920142443 NA NA NA hsa-miR-106b-5p PIK3R1 1.07509411417907 2.11739194181878e-36 -0.234314125271815 0.0111750886765385 MirTarget;miRNATAP -0.179369079303185 0.000816789511004284 NA NA NA hsa-miR-221-3p PIK3R1 0.337895669520713 0.0136448974691037 -0.234314125271815 0.0111750886765385 MirTarget -0.163462882563838 9.21701112965761e-06 NA NA NA hsa-miR-222-3p PIK3R1 0.214811008033524 0.0965295551752457 -0.234314125271815 0.0111750886765385 MirTarget -0.107248741245045 0.00671314109485487 NA NA NA hsa-miR-590-3p PIK3R1 1.13702599385212 3.53435739887793e-22 -0.234314125271815 0.0111750886765385 miRanda;mirMAP -0.106905404095112 0.00880343764678398 NA NA NA hsa-miR-182-5p PIK3R3 -0.608710746044567 0.0025264935278104 0.439819702071113 8.25824839758606e-05 mirMAP -0.153374534942348 3.96734579923425e-07 NA NA NA hsa-miR-339-5p PIK3R3 0.322848334531193 0.0117281778821612 0.439819702071113 8.25824839758606e-05 MirTarget;miRanda -0.192609585710903 6.48743953207512e-05 NA NA NA hsa-miR-365a-3p PIK3R3 0.80809616164259 2.36039522526e-12 0.439819702071113 8.25824839758606e-05 MirTarget -0.16533292375838 0.00153486106521956 NA NA NA hsa-miR-96-5p PIK3R3 -1.00223771166604 3.91564621567028e-06 0.439819702071113 8.25824839758606e-05 mirMAP -0.164731670984697 7.78245878052581e-09 NA NA NA hsa-miR-125a-3p PIK3R5 -0.372794471295036 0.000941729459601642 3.18542758418586 6.04695754116875e-70 miRanda -0.407465916624748 0.000192324867439568 NA NA NA hsa-miR-125a-5p PIK3R5 -0.561874059994802 7.3931856356891e-13 3.18542758418586 6.04695754116875e-70 MirTarget;miRanda -1.34358622921882 2.31129700790236e-20 NA NA NA hsa-miR-125b-5p PIK3R5 -0.825456421494266 2.13029877878434e-15 3.18542758418586 6.04695754116875e-70 MirTarget -0.67295054872876 1.75325492827967e-09 NA NA NA hsa-miR-615-3p PIK3R5 -0.777370544471479 2.08193713560545e-08 3.18542758418586 6.04695754116875e-70 miRanda -0.258205105771951 0.00312779262258178 NA NA NA hsa-miR-30a-5p PPP3CA -0.778411951775343 2.73322451127932e-16 0.0721387123808759 0.234245285293813 miRNAWalker2_validate;miRNATAP -0.118629097747329 0.000383615066757291 NA NA NA hsa-miR-107 PPP3CB 0.140046250553248 0.0943611632552367 -0.487246812937051 5.19737132609125e-20 miRanda -0.100574744257312 0.00721500275471322 NA NA NA hsa-miR-15a-5p PPP3CB 1.42663930007845 1.36006952074963e-57 -0.487246812937051 5.19737132609125e-20 miRNATAP -0.192283738442317 1.15661216413766e-11 NA NA NA hsa-miR-15b-5p PPP3CB 0.773001494057531 1.71784656078957e-16 -0.487246812937051 5.19737132609125e-20 miRNATAP -0.136453760306784 1.39939898640127e-05 NA NA NA hsa-miR-16-5p PPP3CB 0.934012514027655 4.85417898318515e-24 -0.487246812937051 5.19737132609125e-20 miRNATAP -0.134414377057782 1.56084628439769e-05 NA NA NA hsa-miR-330-5p PPP3CB 1.44960468659754 2.12131210588035e-45 -0.487246812937051 5.19737132609125e-20 MirTarget;PITA;miRanda -0.152969334053742 2.9174642891742e-09 NA NA NA hsa-miR-452-5p PPP3CB 2.05325688842141 2.82238393643084e-40 -0.487246812937051 5.19737132609125e-20 MirTarget;miRNATAP -0.117886106917456 6.18756426826884e-12 NA NA NA hsa-miR-590-3p PPP3CB 1.13702599385212 3.53435739887793e-22 -0.487246812937051 5.19737132609125e-20 miRanda -0.12233415261172 5.67792394940471e-07 NA NA NA hsa-miR-500a-3p PPP3CC -1.41379327701944 2.73403824528455e-37 0.254109049885576 7.06908011746755e-08 MirTarget;miRNATAP -0.121534092684039 4.7654464774239e-09 NA NA NA hsa-miR-27b-3p PPP3R1 -0.699527231242518 1.07356023759234e-15 0.157646059727901 0.00380302425401831 miRNATAP -0.147266842249843 7.02192582599604e-06 NA NA NA hsa-miR-30a-5p PPP3R1 -0.778411951775343 2.73322451127932e-16 0.157646059727901 0.00380302425401831 miRNAWalker2_validate;MirTarget;miRNATAP -0.144832345464806 1.24508531197761e-06 NA NA NA hsa-miR-30b-5p PPP3R1 -1.18330589477119 6.8341618466966e-27 0.157646059727901 0.00380302425401831 MirTarget -0.144184046476476 4.67346408532333e-09 NA NA NA hsa-miR-30d-5p PPP3R1 -0.202727675788184 0.00659067084745794 0.157646059727901 0.00380302425401831 MirTarget;miRNATAP -0.210347143440493 1.4459363165293e-07 NA NA NA hsa-miR-16-2-3p PRKACB 1.3046118743965 4.17207934608428e-19 -0.68047992720199 6.2289588419962e-18 mirMAP -0.110421791682537 0.000180893091391508 NA NA NA hsa-miR-17-5p PRKACB 0.494260110870015 3.8348005261e-09 -0.68047992720199 6.2289588419962e-18 TargetScan -0.177111212378275 0.000974492661946987 NA NA NA hsa-miR-18a-5p PRKACB 0.936704393213466 1.05064580570579e-10 -0.68047992720199 6.2289588419962e-18 miRNATAP -0.129810473204045 2.02983188773094e-05 NA NA NA hsa-miR-193a-3p PRKACB 0.849206638484406 3.68101781083335e-14 -0.68047992720199 6.2289588419962e-18 miRanda -0.152325629995289 0.000102213273809685 NA NA NA hsa-miR-19a-3p PRKACB 0.722913586880779 2.76301458932381e-10 -0.68047992720199 6.2289588419962e-18 MirTarget;miRNATAP -0.149521467816826 0.000117450056574833 NA NA NA hsa-miR-19b-3p PRKACB 0.195940928879427 0.0300512922542325 -0.68047992720199 6.2289588419962e-18 miRNAWalker2_validate;MirTarget;miRNATAP -0.151382160966433 0.0030186219386488 NA NA NA hsa-miR-34a-5p PRKACB 1.07544567720768 1.81510842038009e-20 -0.68047992720199 6.2289588419962e-18 miRNATAP -0.155553394908043 2.5599855449644e-05 NA NA NA hsa-miR-590-3p PRKACB 1.13702599385212 3.53435739887793e-22 -0.68047992720199 6.2289588419962e-18 MirTarget;PITA;miRanda;miRNATAP -0.170298039845818 2.59547529658115e-06 NA NA NA hsa-miR-590-5p PRKACB 0.709763558412506 1.11883921359361e-11 -0.68047992720199 6.2289588419962e-18 miRanda -0.122511813057726 0.00404292608644287 NA NA NA hsa-miR-93-5p PRKACB 1.37365940377595 2.37567548683245e-46 -0.68047992720199 6.2289588419962e-18 miRNAWalker2_validate -0.230489200796702 1.41605310708363e-08 NA NA NA hsa-miR-107 PRKAR1A 0.140046250553248 0.0943611632552367 -0.547775645551862 6.19712762597104e-18 miRanda -0.130362282624102 0.00332922016718446 NA NA NA hsa-miR-155-5p PRKAR1A 3.26274490570809 5.06841441826518e-51 -0.547775645551862 6.19712762597104e-18 miRNAWalker2_validate -0.110418576977943 1.32260434007991e-15 NA NA NA hsa-miR-16-2-3p PRKAR1A 1.3046118743965 4.17207934608428e-19 -0.547775645551862 6.19712762597104e-18 mirMAP -0.110081442622622 2.95996607063381e-06 NA NA NA hsa-miR-16-5p PRKAR1A 0.934012514027655 4.85417898318515e-24 -0.547775645551862 6.19712762597104e-18 miRNAWalker2_validate -0.165961545062637 6.90256571724503e-06 NA NA NA hsa-miR-25-3p PRKAR1A 1.12016166564779 3.79069348635778e-48 -0.547775645551862 6.19712762597104e-18 miRNAWalker2_validate -0.25938574282876 1.5457770900793e-10 NA NA NA hsa-miR-342-3p PRKAR1A 1.4124432570595 1.07208971556131e-28 -0.547775645551862 6.19712762597104e-18 miRanda -0.147380654156586 1.53902191093399e-08 NA NA NA hsa-miR-590-3p PRKAR1A 1.13702599385212 3.53435739887793e-22 -0.547775645551862 6.19712762597104e-18 miRanda;mirMAP -0.182795999138848 1.9132308520552e-10 NA NA NA hsa-miR-590-5p PRKAR1A 0.709763558412506 1.11883921359361e-11 -0.547775645551862 6.19712762597104e-18 miRanda -0.161236926904721 1.92543517279383e-06 NA NA NA hsa-let-7b-5p PRKAR2A 0.770868211539597 6.63408323707647e-21 -1.4011174530805 2.31491917147698e-20 miRNAWalker2_validate -0.3160134091974 0.00202961440127807 NA NA NA hsa-let-7f-1-3p PRKAR2A 0.477913872379336 4.46669616865068e-05 -1.4011174530805 2.31491917147698e-20 mirMAP -0.298548413368089 0.000243458395884904 NA NA NA hsa-miR-103a-3p PRKAR2A 0.779373475434461 7.37867196796994e-20 -1.4011174530805 2.31491917147698e-20 miRNAWalker2_validate -0.552435883992741 1.2533633936404e-08 NA NA NA hsa-miR-106b-5p PRKAR2A 1.07509411417907 2.11739194181878e-36 -1.4011174530805 2.31491917147698e-20 mirMAP -0.912716905973522 6.93622932875167e-26 NA NA NA hsa-miR-140-5p PRKAR2A 0.504309496243674 3.09884038729031e-11 -1.4011174530805 2.31491917147698e-20 miRanda -0.324109335962293 0.0048262874300068 NA NA NA hsa-miR-142-5p PRKAR2A 1.88417391525707 1.2096808039882e-27 -1.4011174530805 2.31491917147698e-20 mirMAP -0.284502149249807 6.79033207924826e-10 NA NA NA hsa-miR-146b-5p PRKAR2A 1.40714170253819 2.9559871816487e-12 -1.4011174530805 2.31491917147698e-20 miRanda -0.20299350669257 1.39541499890942e-06 NA NA NA hsa-miR-151a-3p PRKAR2A 0.657909055193034 1.46651056355997e-25 -1.4011174530805 2.31491917147698e-20 mirMAP -0.645007282243932 9.01925946901272e-07 NA NA NA hsa-miR-155-5p PRKAR2A 3.26274490570809 5.06841441826518e-51 -1.4011174530805 2.31491917147698e-20 miRNAWalker2_validate -0.273016066907206 2.44203658321578e-16 NA NA NA hsa-miR-16-5p PRKAR2A 0.934012514027655 4.85417898318515e-24 -1.4011174530805 2.31491917147698e-20 miRNAWalker2_validate -0.496222030177156 2.00269052060567e-08 NA NA NA hsa-miR-17-5p PRKAR2A 0.494260110870015 3.8348005261e-09 -1.4011174530805 2.31491917147698e-20 mirMAP -0.506020229299244 9.50290746072584e-07 NA NA NA hsa-miR-193b-5p PRKAR2A 0.277625648727715 0.101981573602756 -1.4011174530805 2.31491917147698e-20 mirMAP -0.14097478653086 0.00806748983136429 NA NA NA hsa-miR-20a-5p PRKAR2A 0.702602695798242 4.06372887613329e-13 -1.4011174530805 2.31491917147698e-20 mirMAP -0.514083357521696 3.72636429326654e-09 NA NA NA hsa-miR-21-5p PRKAR2A 2.51462371613332 3.30620591950316e-66 -1.4011174530805 2.31491917147698e-20 mirMAP -0.44723085806505 5.30365656089105e-22 NA NA NA hsa-miR-25-3p PRKAR2A 1.12016166564779 3.79069348635778e-48 -1.4011174530805 2.31491917147698e-20 mirMAP -0.65268487161303 2.33097981071183e-11 NA NA NA hsa-miR-28-5p PRKAR2A 0.461962042257226 3.32424690573327e-11 -1.4011174530805 2.31491917147698e-20 miRanda -0.656180338768824 1.1624290118007e-07 NA NA NA hsa-miR-32-5p PRKAR2A 0.407826130035097 7.26884631998646e-06 -1.4011174530805 2.31491917147698e-20 mirMAP -0.39302723716435 4.81222232692706e-05 NA NA NA hsa-miR-320a PRKAR2A 0.412740558379182 2.02929519701706e-05 -1.4011174530805 2.31491917147698e-20 mirMAP -0.334352847450512 0.000238319352815468 NA NA NA hsa-miR-320b PRKAR2A 0.300497419754843 0.0245219177384172 -1.4011174530805 2.31491917147698e-20 mirMAP -0.244099596847313 0.000230908014567792 NA NA NA hsa-miR-330-3p PRKAR2A 0.912906550436308 3.35037014057665e-13 -1.4011174530805 2.31491917147698e-20 mirMAP -0.268810794644084 0.000111696010536507 NA NA NA hsa-miR-330-5p PRKAR2A 1.44960468659754 2.12131210588035e-45 -1.4011174530805 2.31491917147698e-20 miRanda -0.465844872622759 2.58503908282888e-10 NA NA NA hsa-miR-342-5p PRKAR2A 1.37011183051517 4.99462376051624e-28 -1.4011174530805 2.31491917147698e-20 miRNATAP -0.373291059478551 5.94139009984974e-09 NA NA NA hsa-miR-421 PRKAR2A 0.313155739887734 0.020433534776003 -1.4011174530805 2.31491917147698e-20 mirMAP -0.178888644731219 0.00856710971917874 NA NA NA hsa-miR-590-5p PRKAR2A 0.709763558412506 1.11883921359361e-11 -1.4011174530805 2.31491917147698e-20 mirMAP -0.426330267318752 1.71294111540552e-07 NA NA NA hsa-miR-616-5p PRKAR2A 0.913426384742148 3.78418389333709e-09 -1.4011174530805 2.31491917147698e-20 mirMAP -0.176457961142769 0.00192664007456722 NA NA NA hsa-miR-92a-3p PRKAR2A 0.178194888895831 0.0088835082650834 -1.4011174530805 2.31491917147698e-20 mirMAP -0.391095003849313 0.00315230083896663 NA NA NA hsa-miR-92b-3p PRKAR2A 0.418630595140165 6.50466149211154e-05 -1.4011174530805 2.31491917147698e-20 mirMAP -0.356365024254629 2.10938695392291e-05 NA NA NA hsa-let-7a-3p PRKAR2B 0.0677487960013088 0.460458477653989 -2.39856647321028 1.21009224467775e-59 mirMAP -0.284589027967896 0.00838100690513614 NA NA NA hsa-let-7f-1-3p PRKAR2B 0.477913872379336 4.46669616865068e-05 -2.39856647321028 1.21009224467775e-59 mirMAP -0.280817069908638 0.0017954118393813 NA NA NA hsa-miR-107 PRKAR2B 0.140046250553248 0.0943611632552367 -2.39856647321028 1.21009224467775e-59 miRanda -0.544447009426007 3.334824265367e-06 NA NA NA hsa-miR-186-5p PRKAR2B 0.507217561043443 9.04455748270995e-10 -2.39856647321028 1.21009224467775e-59 mirMAP -0.314567711986533 0.00696438663654799 NA NA NA hsa-miR-32-5p PRKAR2B 0.407826130035097 7.26884631998646e-06 -2.39856647321028 1.21009224467775e-59 miRNATAP -0.556583018037938 1.38556986148401e-07 NA NA NA hsa-miR-361-5p PRKAR2B 0.0514169367202078 0.382929376393199 -2.39856647321028 1.21009224467775e-59 miRanda -0.680294343521277 6.20655207994758e-05 NA NA NA hsa-miR-450b-5p PRKAR2B 0.404819502355575 0.00357671373841274 -2.39856647321028 1.21009224467775e-59 mirMAP;miRNATAP -0.191011029239212 0.00664557212879792 NA NA NA hsa-miR-452-5p PRKAR2B 2.05325688842141 2.82238393643084e-40 -2.39856647321028 1.21009224467775e-59 miRNATAP -0.484725977059167 3.98196621579885e-20 NA NA NA hsa-miR-590-3p PRKAR2B 1.13702599385212 3.53435739887793e-22 -2.39856647321028 1.21009224467775e-59 miRNAWalker2_validate;miRanda -0.621375819945361 1.02191056073703e-16 NA NA NA hsa-miR-126-5p PRKX 0.785607261431085 5.77058629454465e-13 -0.824466674997549 1.24178637796187e-14 MirTarget;miRNATAP -0.225620112374926 3.14306953584905e-05 NA NA NA hsa-miR-128-3p PRKX 0.475045893035043 2.6255647468e-06 -0.824466674997549 1.24178637796187e-14 MirTarget -0.354668377255749 1.84548885162361e-09 NA NA NA hsa-miR-140-3p PRKX 0.989350547007025 6.14964028267239e-25 -0.824466674997549 1.24178637796187e-14 mirMAP -0.238393239812655 5.88038969986026e-05 NA NA NA hsa-miR-143-5p PRKX 0.297037599500085 0.0442949119420742 -0.824466674997549 1.24178637796187e-14 miRNATAP -0.112746271955476 0.00680173941413137 NA NA NA hsa-miR-144-3p PRKX 1.4617706700291 9.18139413836375e-11 -0.824466674997549 1.24178637796187e-14 MirTarget -0.13272578965549 3.71142728059944e-07 NA NA NA hsa-miR-148a-3p PRKX 0.343233211643815 0.00402279073598165 -0.824466674997549 1.24178637796187e-14 MirTarget -0.26948947078394 1.06219908024953e-07 NA NA NA hsa-miR-148b-3p PRKX 0.346011252093377 4.27203463315056e-06 -0.824466674997549 1.24178637796187e-14 MirTarget -0.318456532820279 8.82988200529867e-05 NA NA NA hsa-miR-148b-5p PRKX 0.269550343699955 0.0383631776794927 -0.824466674997549 1.24178637796187e-14 mirMAP -0.130567047783336 0.0074991694843521 NA NA NA hsa-miR-16-1-3p PRKX 1.51429140700091 3.17219833254498e-37 -0.824466674997549 1.24178637796187e-14 MirTarget -0.360359060096853 1.04124203973636e-15 NA NA NA hsa-miR-16-2-3p PRKX 1.3046118743965 4.17207934608428e-19 -0.824466674997549 1.24178637796187e-14 MirTarget;mirMAP -0.185239493595492 2.50440890419259e-06 NA NA NA hsa-miR-181a-5p PRKX 1.11111114875339 3.97880443756442e-29 -0.824466674997549 1.24178637796187e-14 mirMAP -0.354450125800361 1.7110841075268e-10 NA NA NA hsa-miR-181b-5p PRKX 1.49054296272357 3.69051660739368e-41 -0.824466674997549 1.24178637796187e-14 mirMAP -0.309398411713712 7.9863573419145e-11 NA NA NA hsa-miR-195-3p PRKX 0.808592887366705 6.8151241038711e-09 -0.824466674997549 1.24178637796187e-14 MirTarget;mirMAP -0.150691727177806 0.000502555427500189 NA NA NA hsa-miR-19a-3p PRKX 0.722913586880779 2.76301458932381e-10 -0.824466674997549 1.24178637796187e-14 miRNATAP -0.145006279305195 0.00566274166698371 NA NA NA hsa-miR-218-5p PRKX -0.81077534785501 3.0631582201951e-08 -0.824466674997549 1.24178637796187e-14 miRNATAP -0.123260848996704 0.002728147543298 NA NA NA hsa-miR-224-5p PRKX 2.84654230414912 3.0480927226395e-47 -0.824466674997549 1.24178637796187e-14 mirMAP -0.102297987942287 0.000128251231211549 NA NA NA hsa-miR-23a-3p PRKX 0.761438723382355 4.09310879199257e-27 -0.824466674997549 1.24178637796187e-14 mirMAP -0.324733496416332 5.67635968371776e-05 NA NA NA hsa-miR-27a-3p PRKX 0.558934437526245 1.44256383086177e-12 -0.824466674997549 1.24178637796187e-14 MirTarget;miRNATAP -0.250273883699444 0.000969807865024322 NA NA NA hsa-miR-29c-3p PRKX -0.238671318446745 0.0141475322347596 -0.824466674997549 1.24178637796187e-14 mirMAP -0.174256475739199 0.00607897894760014 NA NA NA hsa-miR-330-3p PRKX 0.912906550436308 3.35037014057665e-13 -0.824466674997549 1.24178637796187e-14 MirTarget -0.212099933368802 9.66208692931154e-06 NA NA NA hsa-miR-374a-3p PRKX 1.13863935833993 2.79089304015401e-44 -0.824466674997549 1.24178637796187e-14 mirMAP -0.39192911160223 1.37147903262365e-09 NA NA NA hsa-miR-421 PRKX 0.313155739887734 0.020433534776003 -0.824466674997549 1.24178637796187e-14 miRanda -0.209773371514651 6.65889163437683e-06 NA NA NA hsa-miR-576-5p PRKX 1.06681109513983 5.69294424466526e-24 -0.824466674997549 1.24178637796187e-14 mirMAP -0.187960886178378 0.000516056334679525 NA NA NA hsa-miR-590-3p PRKX 1.13702599385212 3.53435739887793e-22 -0.824466674997549 1.24178637796187e-14 mirMAP -0.299538297188508 4.45201426482462e-10 NA NA NA hsa-miR-625-3p PRKX 1.09679549288964 4.60800634006165e-20 -0.824466674997549 1.24178637796187e-14 mirMAP -0.135091209992979 0.00538503960183476 NA NA NA hsa-miR-30e-5p RELA -0.0905907245198101 0.21196704484334 0.305834629484614 4.05322273913174e-11 miRNAWalker2_validate -0.103369294516701 0.00471206012122476 NA NA NA hsa-miR-362-3p TNFRSF10A -0.753214251798232 3.0025661608035e-07 0.531602946441242 1.56076181971902e-06 miRanda -0.217660473357249 2.40788476784993e-07 NA NA NA hsa-miR-141-3p TNFRSF10B -5.87110686537457 1.20877726722907e-85 1.50103061994547 1.20677028193103e-58 MirTarget -0.179637007346266 6.42698718095789e-37 NA NA NA hsa-miR-200a-3p TNFRSF10B -1.43409013664263 2.00188483717828e-20 1.50103061994547 1.20677028193103e-58 MirTarget -0.236772669541965 8.3251445342918e-11 NA NA NA hsa-miR-26a-5p TNFRSF10B -0.202091714279613 0.00166918288801054 1.50103061994547 1.20677028193103e-58 mirMAP -0.358203768944682 0.000218293956425219 NA NA NA hsa-miR-26b-5p TNFRSF10B -0.251437253429904 0.00270935785098697 1.50103061994547 1.20677028193103e-58 mirMAP -0.258689668765407 0.000446324278700493 NA NA NA hsa-miR-30a-5p TNFRSF10B -0.778411951775343 2.73322451127932e-16 1.50103061994547 1.20677028193103e-58 miRNAWalker2_validate -0.432857683789728 5.99642730242106e-13 NA NA NA hsa-miR-30c-2-3p TNFRSF10B -1.28402709024345 6.77577627955178e-25 1.50103061994547 1.20677028193103e-58 MirTarget -0.380999779921626 2.28457244795636e-18 NA NA NA hsa-miR-3607-3p TNFRSF10B -0.529788328085356 0.00511771034738625 1.50103061994547 1.20677028193103e-58 mirMAP -0.102642098239961 0.00151478445542166 NA NA NA hsa-miR-577 TNFRSF10B -1.48881999472397 7.03080165111147e-10 1.50103061994547 1.20677028193103e-58 mirMAP -0.133612744665596 5.1403176278753e-08 NA NA NA hsa-miR-199b-5p TNFRSF10D -2.39483476763681 1.04659509514884e-17 0.643368256263063 8.85907057510139e-08 miRanda -0.12489362132317 6.17530232153153e-08 NA NA NA hsa-miR-335-5p TNFRSF10D -2.09515619961552 1.03765771499548e-25 0.643368256263063 8.85907057510139e-08 miRNAWalker2_validate -0.159302662470145 3.02269650204586e-07 NA NA NA hsa-miR-362-3p TNFRSF10D -0.753214251798232 3.0025661608035e-07 0.643368256263063 8.85907057510139e-08 miRanda -0.163579300312338 0.000437009689452003 NA NA NA hsa-let-7e-5p TNFRSF1A -0.727009689927955 1.30690859412163e-11 1.05144580156796 6.15984515961538e-37 miRNAWalker2_validate -0.243475340326271 9.72227511621154e-08 NA NA NA hsa-miR-29a-3p TNFRSF1A -0.431613225927952 4.10166815070288e-08 1.05144580156796 6.15984515961538e-37 MirTarget;miRNATAP -0.221660330239268 0.000574068692698324 NA NA NA hsa-miR-29c-3p TNFRSF1A -0.238671318446745 0.0141475322347596 1.05144580156796 6.15984515961538e-37 MirTarget;miRNATAP -0.166214002162491 0.00165168684467284 NA NA NA hsa-miR-221-3p TNFSF10 0.337895669520713 0.0136448974691037 0.579062017848836 1.9578567778316e-05 miRNAWalker2_validate;miRTarBase -0.331808339197113 7.71261287721812e-10 NA NA NA hsa-miR-222-3p TNFSF10 0.214811008033524 0.0965295551752457 0.579062017848836 1.9578567778316e-05 miRNAWalker2_validate;miRTarBase -0.2820728627473 1.14520846865812e-06 NA NA NA hsa-miR-362-3p TNFSF10 -0.753214251798232 3.0025661608035e-07 0.579062017848836 1.9578567778316e-05 miRanda -0.185566183302154 0.000362446664030203 NA NA NA hsa-miR-10b-5p TP53 -0.89971464210447 1.18190532299934e-20 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase -0.178289673371273 1.01311520211069e-07 NA NA NA hsa-miR-125a-5p TP53 -0.561874059994802 7.3931856356891e-13 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase;miRanda -0.169369198879199 8.24720080675124e-05 26389681;21777146;23079745 Mechanistically inactivation of miR-125a during cervical carcinogenesis was caused by HPV suppression of p53 expression;In addition wild-type p53 mRNA and protein expression was increased by hsa-miR-125a-5p overexpression; Moreover blocking wild-type p53 attenuated the effect of hsa-miR-125a-5p on apoptosis; In loss-of-function experiments wild-type p53 mRNA and protein expression was decreased by blocking hsa-miR-125a-5p; The effect of hsa-miR-125a-5p inhibitor on apoptosis was also weakened by blocking wild-type p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity tumorigenesis;; cervical and endocervical cancer;lung cancer;liver cancer hsa-miR-125b-5p TP53 -0.825456421494266 2.13029877878434e-15 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase -0.164499575889924 1.96885947372224e-07 24846940;26335100;24137477;26686386;24402874;21399871;23585871;24762088;24169356;23079745 The results revealed that hsa-miR-125b may regulate multiple biological processes and signal transduction pathways and drug-resistant occurrence is associated with cell proliferation cell apoptosis cell cycle and signaling pathways including MAPK Wnt and p53;The carboxy terminal domain of connexin 43 CT Cx43 modulates the expression of p53 by altering miR 125b expression in low grade human breast cancers; In addition CT-Cx43 was exogenously expressed in the breast cancer-derived cell line MCF-7 and its effect on the expression of miR-125b and its downstream target p53 were evaluated as well as its effect on cellular proliferation and death using MTT and LDH assays respectively; Interestingly we found that miR-125b a negative regulator of p53 exhibited an inverse expression relationship with CT-Cx43 in the breast cancer samples tested;TP53 and hsa-miR-125b were observed to form a self-adaptation association;In this study we have investigated the delivery and transfection of wild-type wt- p53 and microRNA-125b miR-125b expressing plasmid DNA in SK-LU-1 human lung adenocarcinoma cells as well as in KrasG12D/p53fl/fl KP genetically engineered mouse model of lung cancer;miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis;In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells;In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b;A stable overexpression of miR-125b in human melanoma cell line Mel-Juso resulted in a G0/G1 cell cycle block and emergence of large cells expressing senescence markers: senescence-associated beta-galactosidase p21 p27 and p53;MiR 125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK independent pathways; Further studies reveal that p53 is regulated by miR-125b; However downregulation of the endogenous miR-125b also results in p53-independent apoptotic pathway leading to apoptosis in p53 mutated U251 cells and p53 knockdown U87 cells;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity; To show the clinical significance of these findings mutations in the DNA binding domain of p53 and promoter methylation of miR-125b were investigated; Four out of nine patients with induced SIRT7 carried mutations in the p53 gene and one patient showed hypermethylation of the miR-125b promoter region ;;;;immune resistance;;;;; gastric cancer;breast cancer;pancreatic cancer;lung cancer;cervical and endocervical cancer;colorectal cancer;prostate cancer;melanoma;glioblastoma;liver cancer hsa-miR-30d-5p TP53 -0.202727675788184 0.00659067084745794 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate -0.234010250909245 4.72794888119438e-07 NA NA NA hsa-miR-125a-3p TRADD -0.372794471295036 0.000941729459601642 1.50025848595264 1.81341534702503e-57 miRanda -0.183590763320537 0.000822067881362555 NA NA NA hsa-miR-214-5p TRAF2 -1.44418790803397 1.50873538772684e-16 1.00837223645711 2.28827353275856e-27 MirTarget -0.125451680485327 3.28324341648322e-05 NA NA NA hsa-miR-532-3p TRAF2 -1.759223962964 7.9077916669414e-40 1.00837223645711 2.28827353275856e-27 MirTarget -0.198817577762592 4.73764851958879e-08 NA NA NA hsa-miR-101-3p XIAP 0.683973909682285 2.88573524246948e-15 -0.469627492509331 3.89217743489174e-17 miRNAWalker2_validate -0.147697671180407 3.37285714614087e-05 NA NA NA hsa-miR-106b-5p XIAP 1.07509411417907 2.11739194181878e-36 -0.469627492509331 3.89217743489174e-17 miRNATAP -0.306598348062141 6.0104433550302e-22 NA NA NA hsa-miR-140-3p XIAP 0.989350547007025 6.14964028267239e-25 -0.469627492509331 3.89217743489174e-17 mirMAP -0.179926729909407 4.36011089960767e-09 NA NA NA hsa-miR-16-1-3p XIAP 1.51429140700091 3.17219833254498e-37 -0.469627492509331 3.89217743489174e-17 mirMAP -0.136142063365096 1.64726025092488e-08 NA NA NA hsa-miR-17-5p XIAP 0.494260110870015 3.8348005261e-09 -0.469627492509331 3.89217743489174e-17 miRNAWalker2_validate;TargetScan -0.108577220727555 0.00412136076191122 NA NA NA hsa-miR-181a-2-3p XIAP 0.549613348249471 1.48987286432989e-10 -0.469627492509331 3.89217743489174e-17 mirMAP -0.118999240596904 0.00120293255325636 NA NA NA hsa-miR-181a-5p XIAP 1.11111114875339 3.97880443756442e-29 -0.469627492509331 3.89217743489174e-17 miRNAWalker2_validate;miRTarBase;mirMAP -0.178805473397465 8.54922141548072e-10 NA NA NA hsa-miR-181b-5p XIAP 1.49054296272357 3.69051660739368e-41 -0.469627492509331 3.89217743489174e-17 miRNAWalker2_validate;miRTarBase;mirMAP -0.151676640285597 1.37666659027811e-09 NA NA NA hsa-miR-181c-5p XIAP 0.762784646696248 4.48373118147729e-10 -0.469627492509331 3.89217743489174e-17 mirMAP -0.131021406676928 2.31354871741693e-07 NA NA NA hsa-miR-19a-3p XIAP 0.722913586880779 2.76301458932381e-10 -0.469627492509331 3.89217743489174e-17 mirMAP -0.104163059862262 0.000136696531481785 NA NA NA hsa-miR-19b-3p XIAP 0.195940928879427 0.0300512922542325 -0.469627492509331 3.89217743489174e-17 mirMAP -0.122618356120947 0.000618376826547816 NA NA NA hsa-miR-20a-5p XIAP 0.702602695798242 4.06372887613329e-13 -0.469627492509331 3.89217743489174e-17 miRNATAP -0.137576866980809 1.68928697746974e-05 NA NA NA hsa-miR-2355-3p XIAP 1.32757890426926 1.88016636795886e-18 -0.469627492509331 3.89217743489174e-17 MirTarget;miRNATAP -0.110793867520057 5.05506875316648e-08 NA NA NA hsa-miR-23a-3p XIAP 0.761438723382355 4.09310879199257e-27 -0.469627492509331 3.89217743489174e-17 MirTarget;miRNATAP -0.190712269224503 5.9443447192213e-06 26439986 Moreover miR-23a expression correlated inversely with the expression of target gene X-linked inhibitor of apoptosis protein XIAP but positively with the caspase-3/7 activity liver cancer hsa-miR-25-3p XIAP 1.12016166564779 3.79069348635778e-48 -0.469627492509331 3.89217743489174e-17 mirMAP -0.217409364806082 9.80867698728942e-10 NA NA NA hsa-miR-27a-3p XIAP 0.558934437526245 1.44256383086177e-12 -0.469627492509331 3.89217743489174e-17 miRNATAP -0.251675666562521 8.83777295394013e-11 26662313 miR 27a regulates the sensitivity of breast cancer cells to cisplatin treatment via BAK SMAC/DIABLO XIAP axis; After further investigation we indicated that the knockdown of miR-27a promoted the apoptosis via mitochondrial pathway in T-47D cells treated with CDDP depending on the BAK-second mitochondria-derived activator of caspase/direct IAP binding protein with low pI SMAC/DIABLO-X-linked inhibitor of apoptosis XIAP axis breast cancer hsa-miR-28-3p XIAP 1.01277915413238 1.8655970171461e-43 -0.469627492509331 3.89217743489174e-17 mirMAP;miRNATAP -0.147655375883212 0.000129283967018195 NA NA NA hsa-miR-32-5p XIAP 0.407826130035097 7.26884631998646e-06 -0.469627492509331 3.89217743489174e-17 mirMAP -0.124382333624025 0.000399489543196563 NA NA NA hsa-miR-320a XIAP 0.412740558379182 2.02929519701706e-05 -0.469627492509331 3.89217743489174e-17 MirTarget;miRanda;miRNATAP -0.106466105948094 0.00127063615054604 NA NA NA hsa-miR-361-3p XIAP 1.08992546227594 1.13197240706704e-36 -0.469627492509331 3.89217743489174e-17 mirMAP -0.130141852896607 9.68716594445135e-05 NA NA NA hsa-miR-374a-3p XIAP 1.13863935833993 2.79089304015401e-44 -0.469627492509331 3.89217743489174e-17 mirMAP -0.201460978658153 2.87216481454752e-09 NA NA NA hsa-miR-452-5p XIAP 2.05325688842141 2.82238393643084e-40 -0.469627492509331 3.89217743489174e-17 MirTarget;mirMAP -0.101643975910761 1.73861172939819e-08 NA NA NA hsa-miR-590-3p XIAP 1.13702599385212 3.53435739887793e-22 -0.469627492509331 3.89217743489174e-17 MirTarget;miRanda;mirMAP -0.104530085190587 4.40009736985389e-05 NA NA NA hsa-miR-92b-3p XIAP 0.418630595140165 6.50466149211154e-05 -0.469627492509331 3.89217743489174e-17 mirMAP -0.131077599041252 1.55540445951081e-05 NA NA NA