miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-21-5p ABAT 4.38165933891779 1.52536633902505e-92 -0.350733125761804 0.207790456441551 MirTarget -0.180029806558817 0.000214196641688153 NA NA NA hsa-miR-21-5p ABCA1 4.38165933891779 1.52536633902505e-92 -0.919146613554703 6.83156665674163e-06 mirMAP -0.106480029292548 0.00319318372369186 NA NA NA hsa-miR-21-5p ABCA10 4.38165933891779 1.52536633902505e-92 -1.84099349623768 1.22762812617805e-07 mirMAP -0.3335519395681 4.90526967858649e-08 NA NA NA hsa-miR-21-5p ACAT1 4.38165933891779 1.52536633902505e-92 -0.653186153553154 0.000106140715667366 miRNAWalker2_validate -0.151419186770092 2.60538306816165e-07 NA NA NA hsa-miR-21-5p ACER3 4.38165933891779 1.52536633902505e-92 -0.769210136818656 9.3476405314844e-09 mirMAP -0.107351004261569 5.59259077834806e-06 NA NA NA hsa-miR-21-5p ADCY2 4.38165933891779 1.52536633902505e-92 -1.12306124221749 0.0147274014149145 MirTarget -0.421384353419756 1.41554358729248e-07 NA NA NA hsa-miR-196b-5p ADCY9 1.85699053895181 0.000944585924552801 -1.41035089915206 4.71373266738884e-11 miRNATAP -0.120136478308753 6.15158604873123e-12 NA NA NA hsa-miR-9-5p ADCY9 4.99250901331516 2.59132733422801e-19 -1.41035089915206 4.71373266738884e-11 miRNATAP -0.104181604234921 1.11381865279896e-09 NA NA NA hsa-miR-9-5p AKAP13 4.99250901331516 2.59132733422801e-19 -1.20127325864564 1.58040431622387e-11 mirMAP -0.138070532967226 1.08611423075357e-23 NA NA NA hsa-miR-21-5p AKAP6 4.38165933891779 1.52536633902505e-92 -0.985731364883395 0.00065646253920482 MirTarget -0.192854009971156 0.000146394067155892 NA NA NA hsa-miR-21-5p ANKS1B 4.38165933891779 1.52536633902505e-92 -1.49699207533304 0.000307976897243796 MirTarget -0.242556956178012 0.000898021234490578 NA NA NA hsa-miR-21-5p APC 4.38165933891779 1.52536633902505e-92 -0.81362334855622 2.34409310508842e-09 miRNAWalker2_validate -0.144937162471473 1.26897892677296e-09 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-21-5p APH1B 4.38165933891779 1.52536633902505e-92 -1.15616351842544 5.68058985918991e-11 MirTarget -0.252968390807619 1.28468620666558e-16 NA NA NA hsa-miR-21-5p APOLD1 4.38165933891779 1.52536633902505e-92 -2.12744836647965 7.60366449766562e-19 miRNAWalker2_validate -0.262886182090844 1.06142559082947e-09 NA NA NA hsa-miR-9-5p AR 4.99250901331516 2.59132733422801e-19 -1.81828073021777 5.78986294503712e-05 miRNATAP -0.174946023622395 1.0624614495775e-06 NA NA NA hsa-miR-21-5p ARHGAP24 4.38165933891779 1.52536633902505e-92 -1.71260106545945 2.34485903956577e-17 MirTarget;miRNATAP -0.314025545021039 6.73218520393597e-19 NA NA NA hsa-miR-9-5p ARHGAP24 4.99250901331516 2.59132733422801e-19 -1.71260106545945 2.34485903956577e-17 MirTarget;miRNATAP -0.141051876210226 1.29683335561322e-18 NA NA NA hsa-miR-21-5p ARID4A 4.38165933891779 1.52536633902505e-92 -0.599506663153735 1.85125308717463e-06 miRNAWalker2_validate -0.128238254537768 4.69476136893503e-09 NA NA NA hsa-miR-21-5p ARMCX1 4.38165933891779 1.52536633902505e-92 -1.25030015214938 7.29711678333496e-10 MirTarget -0.213997869232832 2.0353750532237e-09 NA NA NA hsa-miR-21-5p ART4 4.38165933891779 1.52536633902505e-92 -3.3669853597577 1.33595494837349e-15 mirMAP -0.652213017156685 7.29970413290217e-19 NA NA NA hsa-miR-9-5p ATP11A 4.99250901331516 2.59132733422801e-19 -0.297804706635747 0.274119720370221 MirTarget;miRNATAP -0.119595963897926 2.02995912484307e-08 NA NA NA hsa-miR-9-5p ATP8A1 4.99250901331516 2.59132733422801e-19 -1.08691258332056 0.000277566672645149 miRNATAP -0.155070040637068 3.48423704989791e-11 NA NA NA hsa-miR-21-5p ATRNL1 4.38165933891779 1.52536633902505e-92 -1.11414808510804 0.0200182231975375 MirTarget -0.408145750975412 9.97939643764938e-07 NA NA NA hsa-miR-9-5p AXL 4.99250901331516 2.59132733422801e-19 -1.36038006878217 4.13952076037311e-09 miRNATAP -0.101237149924702 4.08271179836369e-08 NA NA NA hsa-miR-21-5p B3GALNT1 4.38165933891779 1.52536633902505e-92 -1.5188596887239 3.6959980531233e-09 miRNAWalker2_validate -0.2325514868358 3.16396099611919e-07 NA NA NA hsa-miR-21-5p BACE1 4.38165933891779 1.52536633902505e-92 -0.798549443120606 3.32363960615768e-07 mirMAP -0.135492378994972 8.19823962726491e-07 NA NA NA hsa-miR-21-5p BBS12 4.38165933891779 1.52536633902505e-92 -0.562398036119124 6.16964187495487e-05 MirTarget -0.10824069956516 1.05967682655724e-05 NA NA NA hsa-miR-21-5p BCL2 4.38165933891779 1.52536633902505e-92 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.204010104736014 8.81514964878011e-06 22964582;21468550;25994220;25381586;26555418;23359184;21376256 Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance lung cancer;bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;pancreatic cancer hsa-miR-21-5p BDH2 4.38165933891779 1.52536633902505e-92 -0.82820708907482 3.25752429829762e-07 miRNAWalker2_validate -0.128298647156071 6.98277631948395e-06 NA NA NA hsa-miR-9-5p BEND7 4.99250901331516 2.59132733422801e-19 -1.12483451982321 0.00101241442028845 mirMAP -0.144242106863308 8.98203687837717e-08 NA NA NA hsa-miR-21-5p BMP3 4.38165933891779 1.52536633902505e-92 -1.36969991320004 0.0109180858977145 MirTarget -0.231520850863512 0.0144844165486979 NA NA NA hsa-miR-9-5p BMPER 4.99250901331516 2.59132733422801e-19 -3.65556102540329 1.51541766932314e-14 miRNATAP -0.192670175909549 5.78756027061917e-07 NA NA NA hsa-miR-21-5p BMPR2 4.38165933891779 1.52536633902505e-92 -1.24575126318081 8.97625514457859e-23 miRNAWalker2_validate;miRTarBase;MirTarget -0.196763625666812 1.90921418194688e-18 NA NA NA hsa-miR-21-5p BNC2 4.38165933891779 1.52536633902505e-92 -1.11598908209254 1.25111407267166e-05 miRNATAP -0.151322816323692 0.000791110051760448 NA NA NA hsa-miR-21-5p BOC 4.38165933891779 1.52536633902505e-92 -0.768268736933392 0.00139050960081661 miRNAWalker2_validate -0.150362864532194 0.000364671973101128 NA NA NA hsa-miR-21-5p BTBD3 4.38165933891779 1.52536633902505e-92 -0.592303332736089 0.000497967033829483 miRNAWalker2_validate;miRNATAP -0.19312881960041 4.8782283192504e-11 NA NA NA hsa-miR-9-5p BTBD9 4.99250901331516 2.59132733422801e-19 -0.393240596769459 0.0523724169091932 mirMAP -0.113618885167844 4.69195386344305e-13 NA NA NA hsa-miR-21-5p BTG2 4.38165933891779 1.52536633902505e-92 -1.58604132082518 3.93889483290898e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.359532684260562 1.47441313797972e-14 24821435 miR 21 regulates N methyl N nitro N' nitrosoguanidine induced gastric tumorigenesis by targeting FASLG and BTG2 tumorigenesis gastric cancer hsa-miR-9-5p BTG2 4.99250901331516 2.59132733422801e-19 -1.58604132082518 3.93889483290898e-09 miRNATAP -0.166604404519251 3.12928596940516e-15 NA NA NA hsa-miR-9-5p C15orf52 4.99250901331516 2.59132733422801e-19 -0.969272650717764 0.000287032456915159 mirMAP -0.135262060794938 1.05960957870525e-10 NA NA NA hsa-miR-9-5p C1QL3 4.99250901331516 2.59132733422801e-19 -1.0377126535141 0.0103357492461446 miRNATAP -0.102823502757726 0.00138311400389109 NA NA NA hsa-miR-9-5p CA13 4.99250901331516 2.59132733422801e-19 -0.0208398403209391 0.941744592159906 miRNAWalker2_validate -0.118358905565083 1.195019465876e-07 NA NA NA hsa-miR-196b-5p CACNB4 1.85699053895181 0.000944585924552801 -2.28842727443691 1.30647786946906e-11 miRNATAP -0.112153125111729 6.50572859715669e-05 NA NA NA hsa-miR-21-5p CADM2 4.38165933891779 1.52536633902505e-92 -0.946108973315385 0.0870639273533032 mirMAP;miRNATAP -0.255760064593243 0.00841341886309988 NA NA NA hsa-miR-21-5p CALD1 4.38165933891779 1.52536633902505e-92 -0.848837150897777 2.47165060879416e-05 miRNAWalker2_validate;MirTarget -0.120939783944041 0.000651247883014593 NA NA NA hsa-miR-21-5p CAMK4 4.38165933891779 1.52536633902505e-92 -0.313351726911815 0.298367467257294 mirMAP -0.111713319272916 0.0346531414084967 NA NA NA hsa-miR-196b-5p CBFA2T3 1.85699053895181 0.000944585924552801 -1.50484873891364 1.19741965131561e-07 MirTarget;miRNATAP -0.111974381014509 1.53254515817967e-06 NA NA NA hsa-miR-9-5p CBLN4 4.99250901331516 2.59132733422801e-19 -1.55786297808021 0.000264714950781063 miRNATAP -0.117986571754144 0.000524748732428667 NA NA NA hsa-miR-9-5p CBX7 4.99250901331516 2.59132733422801e-19 -1.83367364294193 5.2355108700289e-19 MirTarget -0.147791056156063 1.55958354583474e-19 NA NA NA hsa-miR-21-5p CCDC152 4.38165933891779 1.52536633902505e-92 -1.44539070142219 1.79527998609678e-09 mirMAP -0.226033354249079 9.79400558005054e-08 NA NA NA hsa-miR-21-5p CCNG1 4.38165933891779 1.52536633902505e-92 -0.381998946658134 0.021474550007251 miRNAWalker2_validate -0.127417479828893 1.0695641766096e-05 NA NA NA hsa-miR-21-5p CCR1 4.38165933891779 1.52536633902505e-92 -0.934305258994418 0.000224219357183293 miRNAWalker2_validate -0.119274927553658 0.0075679862431572 NA NA NA hsa-miR-9-5p CD34 4.99250901331516 2.59132733422801e-19 -1.94857160831009 8.55830651290266e-24 miRNAWalker2_validate -0.136416708927284 2.24162737837027e-18 NA NA NA hsa-miR-21-5p CDK6 4.38165933891779 1.52536633902505e-92 -0.634679756888932 0.0174689602657709 miRNAWalker2_validate;mirMAP -0.148024006269382 0.00157509032784336 NA NA NA hsa-miR-196b-5p CELF2 1.85699053895181 0.000944585924552801 -1.5124889856158 9.92969031878862e-10 miRNATAP -0.176925166379994 3.68814315978637e-19 NA NA NA hsa-miR-21-5p CEP68 4.38165933891779 1.52536633902505e-92 -0.46577917395629 2.10580165862382e-05 miRNATAP -0.113235787849755 2.45867201865302e-09 NA NA NA hsa-miR-9-5p CHST9 4.99250901331516 2.59132733422801e-19 -3.22815222851045 6.39076709360673e-05 miRNATAP -0.136325287684745 0.0350992706308046 NA NA NA hsa-miR-21-5p CLIC2 4.38165933891779 1.52536633902505e-92 -1.25260154689005 1.83580350038276e-06 MirTarget -0.127244115282882 0.0062458725553135 NA NA NA hsa-miR-21-5p CNTFR 4.38165933891779 1.52536633902505e-92 -4.21369767454556 2.77734402633409e-16 miRNATAP -0.788895771367738 2.05910932862296e-18 NA NA NA hsa-miR-9-5p CNTFR 4.99250901331516 2.59132733422801e-19 -4.21369767454556 2.77734402633409e-16 miRNATAP -0.232115720626389 2.76782498463419e-08 NA NA NA hsa-miR-9-5p CNTN3 4.99250901331516 2.59132733422801e-19 -0.471561821564617 0.326639886250142 MirTarget;miRNATAP -0.139483917568203 0.000243810917004434 NA NA NA hsa-miR-9-5p CNTN4 4.99250901331516 2.59132733422801e-19 -2.02447925107852 3.11293125235103e-08 miRNATAP -0.133599874048996 4.98969432030743e-06 NA NA NA hsa-miR-21-5p COBLL1 4.38165933891779 1.52536633902505e-92 -0.936329208296367 1.24981603771865e-06 miRNAWalker2_validate -0.175696709219398 2.12316100705194e-07 NA NA NA hsa-miR-9-5p COLEC12 4.99250901331516 2.59132733422801e-19 -2.36066388772658 2.1766028767652e-12 miRNAWalker2_validate -0.228207880155915 5.39326328136936e-18 NA NA NA hsa-miR-21-5p CPEB3 4.38165933891779 1.52536633902505e-92 -0.654316628303972 1.92506629871146e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.149336418347591 4.06769299583393e-10 NA NA NA hsa-miR-196b-5p CPM 1.85699053895181 0.000944585924552801 -1.23816213392662 0.00015046591709768 miRNATAP -0.12107995939781 5.38387897139893e-06 NA NA NA hsa-miR-21-5p CREBL2 4.38165933891779 1.52536633902505e-92 -0.657680708676696 2.78480702175686e-07 miRNATAP -0.119517336362064 9.65866776764159e-08 NA NA NA hsa-miR-21-5p CRIM1 4.38165933891779 1.52536633902505e-92 -1.64124339109809 1.05920757248863e-14 miRNATAP -0.288449591981418 1.03517968241254e-14 NA NA NA hsa-miR-21-5p CRTC3 4.38165933891779 1.52536633902505e-92 -0.605496798087843 1.18411742527865e-08 mirMAP -0.107330741668281 7.45105863557439e-09 NA NA NA hsa-miR-21-5p CSRNP3 4.38165933891779 1.52536633902505e-92 -0.532908629930247 0.177478198182755 miRNATAP -0.241040618195568 0.00048801581164378 NA NA NA hsa-miR-21-5p CXXC4 4.38165933891779 1.52536633902505e-92 0.0566167029048437 0.898573597373873 mirMAP -0.222609684776617 0.00421427334204567 NA NA NA hsa-miR-21-5p CYBRD1 4.38165933891779 1.52536633902505e-92 -2.17748507522373 1.98852968387199e-15 miRNAWalker2_validate -0.363803521205699 5.35728983899372e-14 NA NA NA hsa-miR-9-5p CYP39A1 4.99250901331516 2.59132733422801e-19 -1.3620337334373 0.00020676418624564 miRNAWalker2_validate -0.105930227131121 0.000289720667585362 NA NA NA hsa-miR-21-5p CYP4V2 4.38165933891779 1.52536633902505e-92 -0.717768287323113 5.890294667917e-05 miRNAWalker2_validate -0.144074664562294 4.13285818209099e-06 NA NA NA hsa-miR-21-5p DAAM1 4.38165933891779 1.52536633902505e-92 -0.443372789601526 0.00894104001985379 miRNAWalker2_validate -0.129454053636255 1.20464740084572e-05 NA NA NA hsa-miR-9-5p DAAM2 4.99250901331516 2.59132733422801e-19 -1.63575002900602 1.24411166382277e-06 mirMAP -0.18157565420421 7.57446997110491e-12 NA NA NA hsa-miR-21-5p DDR2 4.38165933891779 1.52536633902505e-92 -1.71692899343453 3.3190346874248e-08 miRNAWalker2_validate -0.314664741233957 8.12210806982949e-09 NA NA NA hsa-miR-9-5p DENND3 4.99250901331516 2.59132733422801e-19 -1.91453204344163 8.00675200142065e-27 MirTarget -0.107308410049325 2.38683547220119e-13 NA NA NA hsa-miR-21-5p DLGAP1 4.38165933891779 1.52536633902505e-92 -1.79723108110368 0.00120543951319562 miRNATAP -0.463826836702633 1.74324663995501e-06 NA NA NA hsa-miR-9-5p DLX3 4.99250901331516 2.59132733422801e-19 1.11558228889864 0.0316697650240076 miRNATAP -0.115921117410968 0.00496983156280644 NA NA NA hsa-miR-21-5p DMD 4.38165933891779 1.52536633902505e-92 -1.31312850973335 3.19005914779323e-06 miRNAWalker2_validate -0.26089790536749 1.27959294816998e-07 NA NA NA hsa-miR-21-5p DOCK4 4.38165933891779 1.52536633902505e-92 -1.77394531906606 1.08006628943217e-19 miRNAWalker2_validate;miRTarBase -0.291573095787236 2.94729221734495e-17 NA NA NA hsa-miR-196b-5p DOK6 1.85699053895181 0.000944585924552801 -1.81786159410841 1.57948056387054e-08 miRNATAP -0.139443624937501 1.20199546396159e-07 NA NA NA hsa-miR-21-5p DOK6 4.38165933891779 1.52536633902505e-92 -1.81786159410841 1.57948056387054e-08 mirMAP -0.405685233198613 4.07919148131617e-13 NA NA NA hsa-miR-9-5p DPP4 4.99250901331516 2.59132733422801e-19 0.229836539174991 0.611803754576648 miRNATAP -0.101585644583473 0.0046667136547648 NA NA NA hsa-miR-21-5p DST 4.38165933891779 1.52536633902505e-92 -1.46697088328632 7.81274276497184e-08 mirMAP -0.163198782248462 0.000758017564884143 22403704 While the EDCs and estrogen similarly altered the expression of multiple microRNAs in MCF-7 cells including miR-21 differential patterns of microRNA expression were induced by DDT and BPA compared to estrogen breast cancer hsa-miR-21-5p DUSP8 4.38165933891779 1.52536633902505e-92 -0.989196545334459 1.08880812519481e-05 miRNAWalker2_validate;MirTarget -0.125579189054671 0.00156667289625618 NA NA NA hsa-miR-21-5p EDIL3 4.38165933891779 1.52536633902505e-92 -1.62721020554667 2.30031854926051e-05 miRNAWalker2_validate;MirTarget -0.296332683082282 1.15045032277474e-05 NA NA NA hsa-miR-9-5p EGR3 4.99250901331516 2.59132733422801e-19 -1.82604853868859 6.29542543233464e-09 mirMAP -0.113276773498044 6.94033701383316e-06 NA NA NA hsa-miR-21-5p EIF4EBP2 4.38165933891779 1.52536633902505e-92 -0.494383404708366 6.886097817585e-06 miRNAWalker2_validate -0.118409036930839 5.12208358667903e-10 NA NA NA hsa-miR-21-5p EMP2 4.38165933891779 1.52536633902505e-92 -2.84105693629289 4.51236415687906e-33 mirMAP -0.430338392689145 4.94369755944979e-24 NA NA NA hsa-miR-9-5p EPAS1 4.99250901331516 2.59132733422801e-19 -2.60664787334603 2.84648907369482e-36 miRNATAP -0.131600058193947 3.39047802150246e-14 NA NA NA hsa-miR-196b-5p EPHA3 1.85699053895181 0.000944585924552801 -0.878288753532881 0.0244341269965898 MirTarget -0.174866323003198 2.77683566583977e-08 NA NA NA hsa-miR-21-5p EPM2A 4.38165933891779 1.52536633902505e-92 -1.31798574205221 9.94944326025521e-21 miRNAWalker2_validate -0.236940550453212 8.42197762571293e-22 NA NA NA hsa-miR-9-5p ERG 4.99250901331516 2.59132733422801e-19 -2.40530594833686 2.76172827735145e-30 miRNATAP -0.158713408839314 1.7867358900538e-20 NA NA NA hsa-miR-21-5p FAM26E 4.38165933891779 1.52536633902505e-92 -1.29540012901323 2.18717593551867e-08 mirMAP -0.191744184019821 2.72366206658204e-06 NA NA NA hsa-miR-21-5p FAM63B 4.38165933891779 1.52536633902505e-92 -1.00795307954411 7.30335959567998e-08 miRNATAP -0.172068089638966 1.70977028283448e-07 NA NA NA hsa-miR-9-5p FAT3 4.99250901331516 2.59132733422801e-19 -3.31351022608528 4.74987714919919e-14 mirMAP -0.154427155755801 1.52111246035001e-05 NA NA NA hsa-miR-21-5p FBXL17 4.38165933891779 1.52536633902505e-92 -0.579016058989837 1.48139429105833e-05 miRNAWalker2_validate;miRNATAP -0.13376142323072 8.85094432632078e-09 NA NA NA hsa-miR-21-5p FBXO3 4.38165933891779 1.52536633902505e-92 -0.360047015595722 0.00195169004907625 miRNAWalker2_validate -0.106393539762232 1.30208816547589e-07 NA NA NA hsa-miR-21-5p FERMT2 4.38165933891779 1.52536633902505e-92 -1.54180889001218 9.12884009580181e-21 miRNAWalker2_validate -0.254299675987181 2.52118740060562e-18 NA NA NA hsa-miR-21-5p FGD4 4.38165933891779 1.52536633902505e-92 -1.12077186011767 3.09001832484425e-10 MirTarget -0.194503607276819 5.04096084966065e-10 NA NA NA hsa-miR-21-5p FGF18 4.38165933891779 1.52536633902505e-92 -2.01878202132787 1.47991026443687e-06 miRNATAP -0.445995016466712 1.11879820670501e-09 NA NA NA hsa-miR-9-5p FGF18 4.99250901331516 2.59132733422801e-19 -2.01878202132787 1.47991026443687e-06 miRNATAP -0.161460646965575 1.31749803347013e-06 NA NA NA hsa-miR-21-5p FGF2 4.38165933891779 1.52536633902505e-92 -2.54526710952658 2.81433930536102e-18 mirMAP -0.439558209079983 1.20994163416464e-17 NA NA NA hsa-miR-9-5p FGF9 4.99250901331516 2.59132733422801e-19 -1.33489997634345 0.0119359510527769 miRNATAP -0.15314002899298 0.000277214145018446 NA NA NA hsa-miR-21-5p FILIP1L 4.38165933891779 1.52536633902505e-92 -1.00620591446456 2.41534580271525e-05 miRNAWalker2_validate -0.126718961511811 0.00259804968430958 NA NA NA hsa-miR-9-5p FLI1 4.99250901331516 2.59132733422801e-19 -1.88163703190108 4.58488254748209e-20 MirTarget;miRNATAP -0.146082920784975 3.97801788366021e-19 NA NA NA hsa-miR-9-5p FLRT3 4.99250901331516 2.59132733422801e-19 -2.4278272258789 3.94867354801025e-10 MirTarget;miRNATAP -0.23610478969199 1.10488974615855e-14 NA NA NA hsa-miR-21-5p FMNL3 4.38165933891779 1.52536633902505e-92 -0.695370308938343 3.57290052677975e-06 mirMAP -0.104679579024355 7.34790340180689e-05 NA NA NA hsa-miR-21-5p FMOD 4.38165933891779 1.52536633902505e-92 -0.723828194660036 0.00334071758874437 miRNAWalker2_validate;miRTarBase -0.207098743431613 1.47850882979566e-06 19906824;23445447 Gain-of miR-21 function in MSMC and LSMC reduced TGF-beta-induced expression of fibromodulin and TGF-beta-induced factor P < 0.05 and moderately altered the rate of cell growth and caspase-3/7 activity in these cells;Our method exhibits ultrahigh sensitivity toward miR-21 with detection limits of 10 fM at 37 °C and 1 aM at 4 °C which corresponds to nine strands of miR-21 in a 15 μL sample and it is capable of distinguishing among miRNA family members ; sarcoma;breast cancer hsa-miR-9-5p FNIP2 4.99250901331516 2.59132733422801e-19 -1.00654432076351 9.11239081146292e-05 MirTarget;miRNATAP -0.132444731526216 5.09150589756686e-11 NA NA NA hsa-miR-9-5p FOXF2 4.99250901331516 2.59132733422801e-19 -1.69993338225277 4.29805791049164e-09 miRNATAP -0.169681779461512 9.45070121492203e-14 NA NA NA hsa-miR-21-5p FOXN3 4.38165933891779 1.52536633902505e-92 -0.949628248684323 2.67390648820455e-10 miRNAWalker2_validate;mirMAP -0.191869825141126 2.34543228523966e-13 NA NA NA hsa-miR-9-5p FOXO1 4.99250901331516 2.59132733422801e-19 -1.31162455396474 3.74199447053977e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.120713538977689 1.15746457251531e-14 24870723;25017439 Phosphorylation of Akt and forkhead box protein O1 FOXO1 was measured in cells with miR-9 overexpression or curcumin treatment; Western blot analysis showed that both miR-9 overexpression and curcumin similarly caused a significant p<0.05 decline in the phosphorylation of Akt and FOXO1 compared to untreated cells;In this study we explored whether FOXO1 3'UTR can function as a ceRNA in repressing epithelial-to-mesenchymal transition EMT and metastasis of breast cancer cells via regulating miR-9 activity; Follow-up analyses showed that there existed a competition of miR-9 between FOXO1 and E-cadherin-3'UTR ;metastasis ovarian cancer;breast cancer hsa-miR-21-5p FOXP2 4.38165933891779 1.52536633902505e-92 -0.815682657773077 0.0407283790852957 mirMAP -0.199882187340292 0.00427624043541355 NA NA NA hsa-miR-9-5p FREM1 4.99250901331516 2.59132733422801e-19 -2.04011061820312 2.41061506666111e-06 MirTarget -0.135406608740665 8.96021533006006e-05 NA NA NA hsa-miR-21-5p FREM2 4.38165933891779 1.52536633902505e-92 -2.05218851472094 3.34756774119365e-05 mirMAP -0.528677646263105 8.14963514772953e-10 NA NA NA hsa-miR-9-5p FREM2 4.99250901331516 2.59132733422801e-19 -2.05218851472094 3.34756774119365e-05 MirTarget;miRNATAP -0.208612705739503 9.90975333365793e-08 NA NA NA hsa-miR-21-5p FRMD3 4.38165933891779 1.52536633902505e-92 -3.3223201712006 4.66197750212244e-24 MirTarget -0.618913951895209 3.50768297463806e-27 NA NA NA hsa-miR-9-5p FRMD4B 4.99250901331516 2.59132733422801e-19 -1.33496983055744 4.20186874964207e-16 miRNAWalker2_validate -0.111001472763736 1.31372369499039e-17 NA NA NA hsa-miR-9-5p FRY 4.99250901331516 2.59132733422801e-19 -1.86522482005448 1.07395091737952e-15 MirTarget;miRNATAP -0.171080806306198 7.99592670996015e-21 NA NA NA hsa-miR-21-5p FZD4 4.38165933891779 1.52536633902505e-92 -1.78542446608909 5.91969949280441e-18 mirMAP -0.290057279466341 2.0794512089728e-15 NA NA NA hsa-miR-21-5p GAS7 4.38165933891779 1.52536633902505e-92 -1.48964358505321 1.36936213439462e-09 mirMAP -0.211299847609617 1.19733578430314e-06 NA NA NA hsa-miR-196b-5p GATA6 1.85699053895181 0.000944585924552801 -2.27287989509853 1.5459505837377e-13 MirTarget;miRNATAP -0.114285962188097 8.21834297943387e-06 NA NA NA hsa-miR-21-5p GBP4 4.38165933891779 1.52536633902505e-92 -1.46692317894326 1.9702417225718e-07 mirMAP -0.174203137359211 0.000489908442657147 NA NA NA hsa-miR-21-5p GFOD1 4.38165933891779 1.52536633902505e-92 -1.95794144508944 6.72127994744423e-17 mirMAP -0.359144845113169 2.1580804911889e-18 NA NA NA hsa-miR-9-5p GFRA1 4.99250901331516 2.59132733422801e-19 -2.95681573891605 1.07599444341926e-09 mirMAP -0.29550040190909 9.38138175434368e-15 NA NA NA hsa-miR-21-5p GNAQ 4.38165933891779 1.52536633902505e-92 -1.17224720339087 2.22112917896982e-17 miRNAWalker2_validate -0.202655782959787 6.70431356007825e-17 NA NA NA hsa-miR-9-5p GNAQ 4.99250901331516 2.59132733422801e-19 -1.17224720339087 2.22112917896982e-17 mirMAP -0.101764100404779 8.57011892389545e-21 NA NA NA hsa-miR-21-5p GNB4 4.38165933891779 1.52536633902505e-92 -0.773241223004692 8.02059608334668e-05 miRNAWalker2_validate -0.107864200716027 0.00179440282483582 NA NA NA hsa-miR-21-5p GNG2 4.38165933891779 1.52536633902505e-92 -1.07252911873911 1.7090824521982e-08 miRNATAP -0.195454981949984 4.65483751845796e-09 NA NA NA hsa-miR-9-5p GNG7 4.99250901331516 2.59132733422801e-19 -1.41246014447214 2.13793630570999e-07 mirMAP -0.155921330432605 2.93551118394192e-13 NA NA NA hsa-miR-21-5p GPD1L 4.38165933891779 1.52536633902505e-92 -1.02236875787017 2.39444403249844e-06 miRNAWalker2_validate -0.173306709312373 5.44403720626699e-06 NA NA NA hsa-miR-9-5p GPR12 4.99250901331516 2.59132733422801e-19 -0.268477107611382 0.643603438296539 mirMAP -0.134814884330682 0.0033798267689635 NA NA NA hsa-miR-196b-5p GPRASP1 1.85699053895181 0.000944585924552801 -1.21606945100868 1.38070476938978e-08 MirTarget -0.104279981829667 2.38294669166354e-09 NA NA NA hsa-miR-21-5p GRIK3 4.38165933891779 1.52536633902505e-92 -0.465658538871947 0.380358482544615 mirMAP -0.215476861249469 0.0207140663289355 NA NA NA hsa-miR-21-5p GTF2A1 4.38165933891779 1.52536633902505e-92 -0.142611004472868 0.488196504262934 miRNAWalker2_validate -0.121636888775719 0.00071136395272175 NA NA NA hsa-miR-9-5p HEG1 4.99250901331516 2.59132733422801e-19 -2.35912016557493 5.38650916353701e-25 mirMAP -0.120930412090716 1.2519075904214e-10 NA NA NA hsa-miR-21-5p HHIP 4.38165933891779 1.52536633902505e-92 -4.83545289306431 6.13591195464382e-12 mirMAP -0.805148428882933 8.52036571276414e-11 NA NA NA hsa-miR-9-5p HHIP 4.99250901331516 2.59132733422801e-19 -4.83545289306431 6.13591195464382e-12 mirMAP -0.344188261612867 9.62243856192446e-10 NA NA NA hsa-miR-21-5p HIPK1 4.38165933891779 1.52536633902505e-92 -0.531007142742986 2.43704932257444e-05 mirMAP -0.10069796151755 4.75609196581215e-06 NA NA NA hsa-miR-21-5p HIPK3 4.38165933891779 1.52536633902505e-92 -1.00953493021249 3.74742869190281e-07 MirTarget -0.217707850716492 3.30912125399018e-10 NA NA NA hsa-miR-196b-5p HLF 1.85699053895181 0.000944585924552801 -2.4892394093974 8.54233660441646e-08 miRNATAP -0.315389934457847 2.08039237480284e-17 NA NA NA hsa-miR-21-5p HPS5 4.38165933891779 1.52536633902505e-92 -1.17298282619125 2.20966154672726e-22 miRNAWalker2_validate -0.168634547254875 4.16926875104036e-15 NA NA NA hsa-miR-21-5p HSD17B4 4.38165933891779 1.52536633902505e-92 -1.05200367579332 8.56870559684427e-14 MirTarget -0.212509643994403 3.84520382313383e-18 NA NA NA hsa-miR-9-5p HUNK 4.99250901331516 2.59132733422801e-19 -0.70875047786782 0.0667721622232869 miRNATAP -0.115242768426243 0.000165719010338976 NA NA NA hsa-miR-9-5p ID4 4.99250901331516 2.59132733422801e-19 -2.43613639689426 1.04558214775527e-12 miRNAWalker2_validate -0.174065002916594 1.99757072746437e-10 NA NA NA hsa-miR-21-5p IL1B 4.38165933891779 1.52536633902505e-92 -1.4197099567083 1.3846626069017e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.134391564023665 0.0201828525145957 NA NA NA hsa-miR-9-5p IL33 4.99250901331516 2.59132733422801e-19 -2.76082371491335 1.78039730795752e-14 MirTarget -0.232639587727837 3.68806341137331e-16 NA NA NA hsa-miR-21-5p IL6R 4.38165933891779 1.52536633902505e-92 -1.1746226729414 2.27195491770167e-06 MirTarget;miRNATAP -0.198071898371476 5.86460332384805e-06 NA NA NA hsa-miR-21-5p IL6ST 4.38165933891779 1.52536633902505e-92 -1.39734012929419 9.70680145490152e-07 mirMAP -0.297109673399402 2.53136271525559e-09 NA NA NA hsa-miR-21-5p ING3 4.38165933891779 1.52536633902505e-92 -0.40090604096619 0.000215441087591831 MirTarget -0.101973851354894 5.81736890893163e-08 NA NA NA hsa-miR-21-5p IRAK3 4.38165933891779 1.52536633902505e-92 -1.31653047867367 9.84276567820939e-06 mirMAP -0.201892704895579 0.000120101491819665 NA NA NA hsa-miR-21-5p ITGA1 4.38165933891779 1.52536633902505e-92 -0.773741524466799 0.000502895577469888 mirMAP -0.113223257366266 0.00383351078993403 NA NA NA hsa-miR-21-5p ITGA8 4.38165933891779 1.52536633902505e-92 -3.15124279620377 2.20806819414868e-12 mirMAP -0.612096953356325 6.15646517857185e-15 NA NA NA hsa-miR-21-5p JAG1 4.38165933891779 1.52536633902505e-92 -0.942765505739303 9.50126957654178e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.193527449412169 4.82269191450352e-06 NA NA NA hsa-miR-21-5p JPH1 4.38165933891779 1.52536633902505e-92 -1.04836308867285 0.00210505112881115 miRNAWalker2_validate;miRNATAP -0.231437601505607 0.000108112493353006 NA NA NA hsa-miR-21-5p KBTBD7 4.38165933891779 1.52536633902505e-92 -0.360533021252892 0.0390962936391078 miRNAWalker2_validate -0.185330867281646 7.7818636783874e-10 NA NA NA hsa-miR-21-5p KCNA1 4.38165933891779 1.52536633902505e-92 -0.611021034587361 0.224689293964146 miRNATAP -0.251920249003611 0.00429217056472806 NA NA NA hsa-miR-21-5p KCNA3 4.38165933891779 1.52536633902505e-92 -1.43557192522843 0.000198575390696743 miRNATAP -0.205747612530112 0.00249043163509765 NA NA NA hsa-miR-9-5p KCNB1 4.99250901331516 2.59132733422801e-19 -2.32252062179519 1.54761796976044e-06 mirMAP -0.155685167629787 5.5534195653932e-05 NA NA NA hsa-miR-9-5p KCNJ15 4.99250901331516 2.59132733422801e-19 -2.22790414754741 4.29639593813642e-07 miRNAWalker2_validate -0.215959672894508 5.73110654844683e-10 NA NA NA hsa-miR-21-5p KCNJ5 4.38165933891779 1.52536633902505e-92 -2.49069343710864 6.87955168722841e-11 mirMAP -0.482869415630147 4.90286682758354e-13 NA NA NA hsa-miR-21-5p KCNK3 4.38165933891779 1.52536633902505e-92 -3.04642728910905 6.7427236874009e-12 mirMAP -0.628865683053097 4.08249279550921e-16 NA NA NA hsa-miR-9-5p KCNK3 4.99250901331516 2.59132733422801e-19 -3.04642728910905 6.7427236874009e-12 mirMAP -0.163383520574217 5.12076800041194e-06 NA NA NA hsa-miR-9-5p KCNS1 4.99250901331516 2.59132733422801e-19 -2.25306034901289 3.33498080454273e-05 mirMAP -0.101058234630942 0.0201881138056283 NA NA NA hsa-miR-21-5p KCTD12 4.38165933891779 1.52536633902505e-92 -1.55864611988997 5.53497502657203e-12 mirMAP -0.283008648823052 9.79027143506793e-13 NA NA NA hsa-miR-9-5p KCTD12 4.99250901331516 2.59132733422801e-19 -1.55864611988997 5.53497502657203e-12 MirTarget;miRNATAP -0.109669315145655 1.34310224261001e-09 NA NA NA hsa-miR-21-5p KIAA0355 4.38165933891779 1.52536633902505e-92 -0.794626018713564 3.70782171586653e-11 MirTarget -0.145506398716101 4.17416807886388e-12 NA NA NA hsa-miR-21-5p KIAA1671 4.38165933891779 1.52536633902505e-92 -0.405714238101275 0.0192393364847213 mirMAP -0.115092137886682 0.000144450603103975 NA NA NA hsa-miR-196b-5p KIAA2022 1.85699053895181 0.000944585924552801 -0.864760969369959 0.0925381203610689 miRNATAP -0.206908089407288 6.38009211756589e-07 NA NA NA hsa-miR-9-5p KIAA2022 4.99250901331516 2.59132733422801e-19 -0.864760969369959 0.0925381203610689 miRNATAP -0.186769863494062 4.06294612664628e-06 NA NA NA hsa-miR-9-5p KIF1C 4.99250901331516 2.59132733422801e-19 -1.40025406363242 2.04407418110822e-21 miRNATAP -0.102630387819458 3.14394632361745e-18 NA NA NA hsa-miR-9-5p KITLG 4.99250901331516 2.59132733422801e-19 -0.407275826421595 0.0946876733686214 MirTarget -0.107182895596496 1.97865014789599e-08 NA NA NA hsa-miR-21-5p KLF12 4.38165933891779 1.52536633902505e-92 -0.704595640422224 0.00137122160627472 mirMAP -0.13883920806473 0.000325222658594953 NA NA NA hsa-miR-9-5p KLF13 4.99250901331516 2.59132733422801e-19 -1.61416344728741 1.73032705805029e-20 miRNATAP -0.103179238325144 2.1579072707642e-13 NA NA NA hsa-miR-21-5p KLF6 4.38165933891779 1.52536633902505e-92 -1.7030104385975 3.79580720085804e-19 miRNATAP -0.208739517096069 1.04215866329701e-09 NA NA NA hsa-miR-21-5p KLF9 4.38165933891779 1.52536633902505e-92 -1.73254014923348 2.18230564186403e-17 miRNAWalker2_validate -0.222580017807528 1.11715395717882e-09 NA NA NA hsa-miR-9-5p KLHDC7A 4.99250901331516 2.59132733422801e-19 -0.195203096326016 0.668115674333374 MirTarget -0.164938782109532 4.19401289163602e-06 NA NA NA hsa-miR-21-5p KLHL4 4.38165933891779 1.52536633902505e-92 -1.81045914680295 1.8884926261865e-07 mirMAP -0.273288708666757 8.39418296081414e-06 NA NA NA hsa-miR-21-5p LAMA4 4.38165933891779 1.52536633902505e-92 -1.307569595124 1.13096764436653e-09 MirTarget -0.182825765991897 1.50535502445258e-06 NA NA NA hsa-miR-21-5p LANCL3 4.38165933891779 1.52536633902505e-92 -1.25841925286578 0.00720115188296336 MirTarget -0.35947812909807 1.12109519448924e-05 NA NA NA hsa-miR-9-5p LANCL3 4.99250901331516 2.59132733422801e-19 -1.25841925286578 0.00720115188296336 mirMAP -0.208562802249751 1.43585159634216e-08 NA NA NA hsa-miR-21-5p LATS1 4.38165933891779 1.52536633902505e-92 -0.447822414619614 0.00448864298940338 miRNAWalker2_validate -0.10490693165907 0.000141065138433488 25769949 miR 21 modulates resistance of HR HPV positive cervical cancer cells to radiation through targeting LATS1; By using dual luciferase assay we verified a binding site between miR-21 and 3'-UTR of large tumor suppressor kinase 1 LATS1; Through direct binding miR-21 can regulate LATS1 expression in cervical cancer cells; LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment drug resistance cervical and endocervical cancer hsa-miR-21-5p LCORL 4.38165933891779 1.52536633902505e-92 -0.446917973223096 0.00400688213774555 miRNAWalker2_validate;miRNATAP -0.119128357474198 1.09697486861365e-05 NA NA NA hsa-miR-9-5p LHFP 4.99250901331516 2.59132733422801e-19 -1.86469898320785 5.24407926375965e-23 MirTarget;miRNATAP -0.112400550536339 2.47322459205156e-13 NA NA NA hsa-miR-21-5p LIFR 4.38165933891779 1.52536633902505e-92 -1.91304148064928 1.12145169149694e-12 miRNAWalker2_validate -0.346683857713576 2.01433771532352e-13 NA NA NA hsa-miR-21-5p LIMCH1 4.38165933891779 1.52536633902505e-92 -1.88651295681958 4.94557486912383e-14 miRNAWalker2_validate -0.305815673998597 4.65664205016323e-12 NA NA NA hsa-miR-21-5p LNPEP 4.38165933891779 1.52536633902505e-92 -0.492332435094547 0.00884906231559745 mirMAP -0.102112094775442 0.00196146933712059 NA NA NA hsa-miR-9-5p LPXN 4.99250901331516 2.59132733422801e-19 -1.1710836553839 1.85056438496006e-09 miRNAWalker2_validate -0.100323334498873 8.15453286653606e-11 NA NA NA hsa-miR-21-5p LRRC55 4.38165933891779 1.52536633902505e-92 -0.929921397443619 0.0370648797520749 mirMAP -0.258948173134403 0.000924626633389361 NA NA NA hsa-miR-21-5p LRRFIP1 4.38165933891779 1.52536633902505e-92 -0.891751911171148 8.100229716027e-13 miRNAWalker2_validate;miRTarBase -0.134959011554471 8.26810715416445e-10 19559015 MicroRNA 21 targets LRRFIP1 and contributes to VM 26 resistance in glioblastoma multiforme; We further identified and validated LRRFIP1 whose product is an inhibitor of NF-kappaB signaling as a direct target gene of miR-21 drug resistance glioblastoma hsa-miR-9-5p LRRTM1 4.99250901331516 2.59132733422801e-19 0.0298852935817289 0.964182815560183 miRNAWalker2_validate -0.146938609974765 0.00536476722621038 NA NA NA hsa-miR-9-5p LRRTM4 4.99250901331516 2.59132733422801e-19 -2.78953430245776 2.40317495159501e-10 miRNATAP -0.116072906087115 0.00111849424974479 NA NA NA hsa-miR-21-5p LZTFL1 4.38165933891779 1.52536633902505e-92 -0.756424799313891 9.86962049346697e-09 MirTarget -0.155185835861618 1.42806438454951e-11 NA NA NA hsa-miR-21-5p MATN2 4.38165933891779 1.52536633902505e-92 -1.53279876540753 1.03020756689882e-05 miRNATAP -0.421755026183514 2.37249481837976e-12 NA NA NA hsa-miR-21-5p MBNL3 4.38165933891779 1.52536633902505e-92 -0.874006580481467 0.00178579729687017 MirTarget;mirMAP -0.254655157900981 1.73643919064795e-07 NA NA NA hsa-miR-21-5p MBP 4.38165933891779 1.52536633902505e-92 -0.922052075942358 4.12083786820759e-08 mirMAP -0.170270611870989 7.43514267411316e-09 NA NA NA hsa-miR-21-5p MCC 4.38165933891779 1.52536633902505e-92 -1.58784768441501 1.65864254265538e-11 mirMAP -0.26808895512467 1.07178578356189e-10 NA NA NA hsa-miR-9-5p MCC 4.99250901331516 2.59132733422801e-19 -1.58784768441501 1.65864254265538e-11 miRNAWalker2_validate;MirTarget -0.12587065275842 1.95375744239341e-11 NA NA NA hsa-miR-9-5p MDGA1 4.99250901331516 2.59132733422801e-19 -2.30797756667285 2.10074563224398e-14 miRNATAP -0.10928318373261 8.31247018578089e-06 NA NA NA hsa-miR-21-5p MEF2A 4.38165933891779 1.52536633902505e-92 -0.85178624451028 2.86227447376792e-17 miRNAWalker2_validate -0.131769779880213 1.2306263579455e-13 NA NA NA hsa-miR-21-5p MEF2C 4.38165933891779 1.52536633902505e-92 -0.861737319401213 4.52234474023972e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.139612775050524 0.000172416351408651 NA NA NA hsa-miR-9-5p MEF2C 4.99250901331516 2.59132733422801e-19 -0.861737319401213 4.52234474023972e-05 MirTarget;miRNATAP -0.120933812278151 2.10238417166847e-13 NA NA NA hsa-miR-21-5p MEGF11 4.38165933891779 1.52536633902505e-92 -3.06369147112619 2.31079520073399e-07 mirMAP -0.691127398503324 2.1315696953115e-11 NA NA NA hsa-miR-21-5p MEGF9 4.38165933891779 1.52536633902505e-92 -0.897455475994798 3.20290367005342e-05 miRNAWalker2_validate;mirMAP;miRNATAP -0.163132258402 1.67003403531948e-05 NA NA NA hsa-miR-21-5p MEIS1 4.38165933891779 1.52536633902505e-92 -1.19033613433878 1.0641966139041e-09 miRNAWalker2_validate -0.191888354825255 2.40492416187473e-08 NA NA NA hsa-miR-21-5p MOAP1 4.38165933891779 1.52536633902505e-92 -0.694677796623788 1.51941403924559e-06 miRNAWalker2_validate -0.178023767191181 1.00827187376798e-12 NA NA NA hsa-miR-21-5p MPP5 4.38165933891779 1.52536633902505e-92 -0.650214136806933 9.24407787146396e-08 miRNAWalker2_validate -0.104386854952987 1.0470645510373e-06 NA NA NA hsa-miR-21-5p MRAP2 4.38165933891779 1.52536633902505e-92 -1.95265199735142 0.000103140012128933 miRNAWalker2_validate -0.446789218470455 3.77760310860315e-07 NA NA NA hsa-miR-9-5p MSR1 4.99250901331516 2.59132733422801e-19 -2.7339266554657 4.23646877025054e-18 mirMAP -0.125859330893739 1.04356296964557e-06 NA NA NA hsa-miR-21-5p MSX1 4.38165933891779 1.52536633902505e-92 -1.32761041242429 9.61922053766115e-07 miRNATAP -0.137818685907996 0.00411890834301053 NA NA NA hsa-miR-21-5p MTMR12 4.38165933891779 1.52536633902505e-92 -0.476008809608839 0.000338908614520091 miRNAWalker2_validate;miRNATAP -0.108206470788489 3.02223623975321e-06 NA NA NA hsa-miR-21-5p MTMR9 4.38165933891779 1.52536633902505e-92 -0.601905224296393 6.79674040736276e-07 miRNAWalker2_validate -0.119483780263808 1.59884763550854e-08 NA NA NA hsa-miR-21-5p MYCBP2 4.38165933891779 1.52536633902505e-92 -0.473758856352263 0.00164067201771206 miRNAWalker2_validate -0.12170829568383 3.50020075013214e-06 NA NA NA hsa-miR-9-5p MYLK 4.99250901331516 2.59132733422801e-19 -1.63193711258573 1.44155005364888e-11 miRNAWalker2_validate -0.100344172078578 2.35758738740161e-07 NA NA NA hsa-miR-21-5p MYO9A 4.38165933891779 1.52536633902505e-92 -1.08935917805551 2.05041560641208e-08 miRNAWalker2_validate -0.19956973279047 4.69149121750198e-09 NA NA NA hsa-miR-9-5p MYOCD 4.99250901331516 2.59132733422801e-19 -2.8500219910234 1.20378349612206e-10 MirTarget;miRNATAP -0.260487519344193 9.51496206364262e-14 NA NA NA hsa-miR-21-5p N4BP2L1 4.38165933891779 1.52536633902505e-92 -1.39572843335407 1.22193238814845e-11 MirTarget -0.230709101409417 2.03499354344659e-10 NA NA NA hsa-miR-21-5p NBEA 4.38165933891779 1.52536633902505e-92 -0.282850332093944 0.374910904415957 miRNAWalker2_validate;miRNATAP -0.137759299249512 0.0137176348329293 NA NA NA hsa-miR-21-5p NDST1 4.38165933891779 1.52536633902505e-92 -1.68425921998113 1.58986813515246e-27 mirMAP -0.275700962205124 9.0354373985241e-24 NA NA NA hsa-miR-21-5p NEK1 4.38165933891779 1.52536633902505e-92 -0.599998467417822 5.86040434181892e-05 miRNAWalker2_validate -0.129935342076424 6.2511375854516e-07 NA NA NA hsa-miR-9-5p NFASC 4.99250901331516 2.59132733422801e-19 -2.01223219081323 6.05102986087567e-10 mirMAP;miRNATAP -0.101184286452187 0.000112328205762756 NA NA NA hsa-miR-9-5p NFATC2 4.99250901331516 2.59132733422801e-19 -1.17929519652878 0.000402858371584528 MirTarget -0.105804655043001 6.44752588454657e-05 NA NA NA hsa-miR-21-5p NFIA 4.38165933891779 1.52536633902505e-92 -1.00397429875229 4.52451080496823e-06 MirTarget;miRNATAP -0.231557232853265 1.2793209466531e-09 NA NA NA hsa-miR-9-5p NFIA 4.99250901331516 2.59132733422801e-19 -1.00397429875229 4.52451080496823e-06 mirMAP;miRNATAP -0.139125619602566 2.68323777060429e-16 NA NA NA hsa-miR-21-5p NFIB 4.38165933891779 1.52536633902505e-92 -0.740451359073183 0.000216852275534707 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.154134411856654 1.10290025622501e-05 NA NA NA hsa-miR-21-5p NFIC 4.38165933891779 1.52536633902505e-92 -0.779406692188113 2.42155659995516e-05 mirMAP -0.142364082928094 1.1087834147573e-05 NA NA NA hsa-miR-9-5p NHLH2 4.99250901331516 2.59132733422801e-19 -2.02083280266177 8.18317803525009e-05 miRNATAP -0.114986585873378 0.00505314087528046 NA NA NA hsa-miR-21-5p NKD1 4.38165933891779 1.52536633902505e-92 -1.734580414771 4.24665289948679e-06 mirMAP -0.393412938012472 2.27374130691586e-09 NA NA NA hsa-miR-9-5p NOS1 4.99250901331516 2.59132733422801e-19 -4.30278289092904 4.98291187091246e-14 mirMAP -0.20775063411889 7.44781861215127e-06 NA NA NA hsa-miR-196b-5p NOSTRIN 1.85699053895181 0.000944585924552801 -2.07529841033479 3.25797962023632e-11 MirTarget -0.159443136748054 5.03291701273775e-10 NA NA NA hsa-miR-9-5p NOVA2 4.99250901331516 2.59132733422801e-19 -2.2153233189368 2.91992843639491e-22 mirMAP -0.110115782073842 4.14476132129912e-09 NA NA NA hsa-miR-196b-5p NPAS3 1.85699053895181 0.000944585924552801 0.0654531251833039 0.898070311393531 miRNATAP -0.122813399636278 0.0031500712897928 NA NA NA hsa-miR-9-5p NR5A2 4.99250901331516 2.59132733422801e-19 -1.63747659369463 2.38318834529012e-11 miRNATAP -0.105044795637834 9.20601759911634e-08 NA NA NA hsa-miR-21-5p NTF3 4.38165933891779 1.52536633902505e-92 -1.21316884460928 0.000957794321386974 miRTarBase;miRNATAP -0.277170192916863 1.64786275260932e-05 NA NA NA hsa-miR-9-5p NTNG1 4.99250901331516 2.59132733422801e-19 -3.72276151178321 4.7388704008007e-12 miRNATAP -0.235583838061525 5.2512639022432e-08 NA NA NA hsa-miR-21-5p NTRK2 4.38165933891779 1.52536633902505e-92 -2.56364615593132 1.62911334525602e-08 mirMAP -0.470648222362519 3.55420725351027e-09 NA NA NA hsa-miR-21-5p NTRK3 4.38165933891779 1.52536633902505e-92 -2.56483261021588 1.22094180257432e-11 mirMAP -0.450836313240135 1.25027358456362e-11 NA NA NA hsa-miR-9-5p NTRK3 4.99250901331516 2.59132733422801e-19 -2.56483261021588 1.22094180257432e-11 miRNAWalker2_validate;miRTarBase -0.231036546211493 1.10901468018254e-14 NA NA NA hsa-miR-21-5p OLR1 4.38165933891779 1.52536633902505e-92 -2.93745176151469 5.86228746111314e-17 miRNAWalker2_validate -0.290441432549901 4.53275857293122e-06 NA NA NA hsa-miR-21-5p OSBPL1A 4.38165933891779 1.52536633902505e-92 -0.725784561087075 0.000158181913394023 miRNAWalker2_validate -0.163177885401537 1.17386624684048e-06 NA NA NA hsa-miR-21-5p OSBPL6 4.38165933891779 1.52536633902505e-92 -2.00535103317292 5.51349022239837e-08 mirMAP -0.410292360004388 2.03886451876783e-10 NA NA NA hsa-miR-21-5p OSR1 4.38165933891779 1.52536633902505e-92 -1.41829291506856 1.08355269450034e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.286460437462601 1.85732872792404e-08 NA NA NA hsa-miR-21-5p OTUD1 4.38165933891779 1.52536633902505e-92 -1.81019841189268 1.77293817765574e-35 miRNAWalker2_validate -0.265494369751458 4.50517939642484e-24 NA NA NA hsa-miR-21-5p PAIP2B 4.38165933891779 1.52536633902505e-92 -0.276122148364145 0.244236830589508 miRNATAP -0.143766282726154 0.000521477174832977 NA NA NA hsa-miR-21-5p PALLD 4.38165933891779 1.52536633902505e-92 -0.838000069527052 4.97294911559766e-05 miRNAWalker2_validate -0.11821289032001 0.00116523276167147 NA NA NA hsa-miR-9-5p PALMD 4.99250901331516 2.59132733422801e-19 -2.37893520344779 1.38138191792403e-20 MirTarget;miRNATAP -0.176785250096792 5.83775005830545e-18 NA NA NA hsa-miR-196b-5p PAX7 1.85699053895181 0.000944585924552801 2.50842427728122 0.00954240178421587 miRNATAP -0.191399699566222 0.0156599726503231 NA NA NA hsa-miR-21-5p PBX1 4.38165933891779 1.52536633902505e-92 -1.07873775062477 2.94362106445457e-05 miRNAWalker2_validate -0.284209663685734 2.3316303347679e-10 NA NA NA hsa-miR-9-5p PCDH15 4.99250901331516 2.59132733422801e-19 -4.48791098000162 2.0713619700049e-16 mirMAP -0.288336727805545 5.88366264454608e-11 NA NA NA hsa-miR-9-5p PCDH17 4.99250901331516 2.59132733422801e-19 -1.75615895156376 4.72208249995095e-13 MirTarget -0.124899033327464 1.27761800016329e-10 NA NA NA hsa-miR-21-5p PCGF5 4.38165933891779 1.52536633902505e-92 -0.571320946698636 6.3647358939581e-05 mirMAP -0.102667085652521 4.14961383870553e-05 NA NA NA hsa-miR-9-5p PCSK2 4.99250901331516 2.59132733422801e-19 -3.40652219539529 0.000298275846961885 MirTarget;miRNATAP -0.358374293684333 1.55748682963842e-06 NA NA NA hsa-miR-21-5p PDE1C 4.38165933891779 1.52536633902505e-92 -2.57579458677132 4.73048468877379e-09 mirMAP -0.519318702969185 1.44500605566728e-11 NA NA NA hsa-miR-9-5p PDE1C 4.99250901331516 2.59132733422801e-19 -2.57579458677132 4.73048468877379e-09 mirMAP -0.130610649365318 0.00022463428305082 NA NA NA hsa-miR-9-5p PDE7B 4.99250901331516 2.59132733422801e-19 -1.50589746098072 2.68434299561612e-07 miRNATAP -0.134267793995862 7.224805401921e-09 NA NA NA hsa-miR-9-5p PDK4 4.99250901331516 2.59132733422801e-19 -3.02809386565859 6.0733772705676e-17 MirTarget;miRNATAP -0.175759974817731 2.08036634772463e-09 NA NA NA hsa-miR-9-5p PEG3 4.99250901331516 2.59132733422801e-19 -1.84626944783216 5.14240681937209e-09 miRNATAP -0.114299847575885 6.42463141483921e-06 NA NA NA hsa-miR-21-5p PFKFB2 4.38165933891779 1.52536633902505e-92 -0.836175125663924 1.46860287236098e-06 miRNAWalker2_validate;mirMAP -0.12209064037943 6.62814438014477e-05 NA NA NA hsa-miR-9-5p PGR 4.99250901331516 2.59132733422801e-19 -2.31152801696562 4.02917540828198e-13 mirMAP -0.211723980386945 3.42577064912447e-17 NA NA NA hsa-miR-9-5p PHACTR1 4.99250901331516 2.59132733422801e-19 -3.00804502870989 1.07840160671334e-20 miRNATAP -0.214168962014699 1.39525552633988e-16 NA NA NA hsa-miR-21-5p PHACTR2 4.38165933891779 1.52536633902505e-92 -1.68321027518053 5.96237179238673e-21 miRNAWalker2_validate -0.279011164851389 1.17443752354918e-18 NA NA NA hsa-miR-21-5p PIK3R1 4.38165933891779 1.52536633902505e-92 -1.28526113405546 1.1596112892202e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.239855941401679 1.66617444081141e-16 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-9-5p PITPNM3 4.99250901331516 2.59132733422801e-19 -0.614969996179847 0.020011396679978 mirMAP;miRNATAP -0.12612983724512 1.07025835665947e-09 NA NA NA hsa-miR-21-5p PJA2 4.38165933891779 1.52536633902505e-92 -0.731030889675194 1.47563604704509e-08 MirTarget -0.145735129296747 9.37648373176033e-11 NA NA NA hsa-miR-9-5p PLCB4 4.99250901331516 2.59132733422801e-19 -1.82668492890878 7.15026249037583e-05 miRNAWalker2_validate;mirMAP -0.107737977725213 0.00338080296219067 NA NA NA hsa-miR-21-5p PLEKHA1 4.38165933891779 1.52536633902505e-92 -0.794952450631166 1.98101339273862e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.145537480755973 5.50900342484852e-08 NA NA NA hsa-miR-9-5p PLXNA2 4.99250901331516 2.59132733422801e-19 -1.1615915565644 1.97317825006664e-05 mirMAP -0.173501028639824 1.97474505681201e-16 NA NA NA hsa-miR-9-5p PMP22 4.99250901331516 2.59132733422801e-19 -1.48687702477309 1.7919332614432e-13 MirTarget;miRNATAP -0.110031434620238 8.71630741723915e-12 NA NA NA hsa-miR-21-5p POLR3B 4.38165933891779 1.52536633902505e-92 -0.269268314205074 0.0244352045709561 miRNAWalker2_validate -0.100258256960115 1.3613107353e-06 NA NA NA hsa-miR-21-5p PPM1L 4.38165933891779 1.52536633902505e-92 -0.780773337986628 0.00385232931156207 miRNAWalker2_validate -0.276297668063014 3.63512245953493e-09 NA NA NA hsa-miR-196b-5p PPP1R12B 1.85699053895181 0.000944585924552801 -0.81085186665736 0.00020310222408518 miRNATAP -0.125096213494253 8.25367033616473e-13 NA NA NA hsa-miR-9-5p PPP1R12B 4.99250901331516 2.59132733422801e-19 -0.81085186665736 0.00020310222408518 mirMAP -0.113387873302421 3.1739813641787e-11 NA NA NA hsa-miR-21-5p PPP1R16B 4.38165933891779 1.52536633902505e-92 -1.68711593811391 9.25595484504384e-10 mirMAP -0.267675281648734 3.71178364199063e-08 NA NA NA hsa-miR-9-5p PREX2 4.99250901331516 2.59132733422801e-19 -3.08306309814647 5.27124686466038e-14 mirMAP -0.247629296249671 3.01835659632515e-14 NA NA NA hsa-miR-9-5p PRG4 4.99250901331516 2.59132733422801e-19 -4.43060530987292 2.1092109983157e-15 miRNAWalker2_validate -0.376463246113578 1.7271013525097e-17 NA NA NA hsa-miR-21-5p PRICKLE2 4.38165933891779 1.52536633902505e-92 -1.56077600074788 2.11863685620441e-14 miRNAWalker2_validate;MirTarget -0.231680719450712 1.56031172523943e-10 NA NA NA hsa-miR-21-5p PRKAR2A 4.38165933891779 1.52536633902505e-92 -0.542111912815549 0.00820991566022701 mirMAP -0.150363567953701 2.70425744412111e-05 NA NA NA hsa-miR-21-5p PRKCE 4.38165933891779 1.52536633902505e-92 -1.90569572476856 4.14982276483839e-29 miRNAWalker2_validate -0.286744215391274 4.57326872782761e-21 NA NA NA hsa-miR-21-5p PRKG1 4.38165933891779 1.52536633902505e-92 -2.25433524061476 2.63202808294653e-12 mirMAP -0.410785620378776 3.73071401734998e-13 NA NA NA hsa-miR-21-5p PRR5L 4.38165933891779 1.52536633902505e-92 -0.846664174140884 0.000533342747154556 MirTarget -0.100417765818241 0.0198621014243269 NA NA NA hsa-miR-21-5p PRRG1 4.38165933891779 1.52536633902505e-92 -1.22608167695553 3.39224027247247e-07 MirTarget -0.212642267813082 4.87688597399358e-07 NA NA NA hsa-miR-9-5p PSAPL1 4.99250901331516 2.59132733422801e-19 -3.02033485951514 1.21075739775471e-07 mirMAP -0.172144496343406 0.000169658636512602 NA NA NA hsa-miR-21-5p PTCH1 4.38165933891779 1.52536633902505e-92 -0.987681899854243 3.3643657157805e-05 mirMAP -0.294590888878975 7.67375407943529e-13 NA NA NA hsa-miR-9-5p PTCH1 4.99250901331516 2.59132733422801e-19 -0.987681899854243 3.3643657157805e-05 miRNATAP -0.139936463410487 4.56551752381971e-14 25595896 Computational studies real-time PCR reporter gene studies western blots target protector oligos and ectopic expression identified miR-9 as the target of PTCH1 in resistant GBM cells with concomitant activation of SHH signaling; Taken together miR-9 targets PTCH1 in GBM cells by a SHH-independent method in GBM cells for TMZ resistance drug resistance glioblastoma hsa-miR-21-5p PTCHD1 4.38165933891779 1.52536633902505e-92 -2.28515402924446 1.24015260088154e-05 mirMAP -0.463534283142037 4.25846431367738e-07 NA NA NA hsa-miR-9-5p PTCHD1 4.99250901331516 2.59132733422801e-19 -2.28515402924446 1.24015260088154e-05 MirTarget -0.194906894057477 2.74320617692888e-06 NA NA NA hsa-miR-21-5p PTGFR 4.38165933891779 1.52536633902505e-92 -2.72283954557066 1.06089476959028e-09 miRNAWalker2_validate -0.496430600654456 2.40724487071613e-10 NA NA NA hsa-miR-21-5p PTPRB 4.38165933891779 1.52536633902505e-92 -2.94529847612856 3.18846971542684e-31 mirMAP -0.51034797017581 2.84593421499678e-30 NA NA NA hsa-miR-9-5p PTPRB 4.99250901331516 2.59132733422801e-19 -2.94529847612856 3.18846971542684e-31 mirMAP;miRNATAP -0.186119377011611 2.76932638391023e-19 NA NA NA hsa-miR-21-5p PTPRT 4.38165933891779 1.52536633902505e-92 -2.80936308516019 3.80378146944574e-05 mirMAP -0.625699227228023 1.57181219238587e-07 NA NA NA hsa-miR-9-5p PTPRT 4.99250901331516 2.59132733422801e-19 -2.80936308516019 3.80378146944574e-05 mirMAP -0.232533214947502 1.82743865959954e-05 NA NA NA hsa-miR-21-5p PTX3 4.38165933891779 1.52536633902505e-92 -1.94541129344397 1.44165774534121e-08 miRNAWalker2_validate -0.240799492355718 7.65034803848397e-05 NA NA NA hsa-miR-21-5p PYGO1 4.38165933891779 1.52536633902505e-92 -0.953296710186091 0.00221849480340061 mirMAP -0.189088976399504 0.000548596981629246 NA NA NA hsa-miR-21-5p RAB11FIP2 4.38165933891779 1.52536633902505e-92 -0.806116545647679 8.36281602113912e-09 miRNAWalker2_validate -0.159613273890315 6.25395355320962e-11 NA NA NA hsa-miR-21-5p RAB30 4.38165933891779 1.52536633902505e-92 -0.188747957524089 0.370194425790412 mirMAP -0.101255169439876 0.00603257351924249 NA NA NA hsa-miR-21-5p RAPGEF1 4.38165933891779 1.52536633902505e-92 -0.782467103824406 3.90663493420931e-10 mirMAP -0.136002478870012 5.46181629685983e-10 NA NA NA hsa-miR-21-5p RAPGEF6 4.38165933891779 1.52536633902505e-92 -0.587466210174554 0.00590650527331029 miRNAWalker2_validate -0.146060245722631 9.16678101078575e-05 NA NA NA hsa-miR-9-5p RASSF5 4.99250901331516 2.59132733422801e-19 -0.762232040461735 2.73165460783976e-05 mirMAP -0.102233004642707 5.64531687511828e-13 NA NA NA hsa-miR-9-5p RASSF8 4.99250901331516 2.59132733422801e-19 -1.79427432100023 3.30914182856082e-11 miRNAWalker2_validate -0.113931625650889 1.54478176292415e-07 NA NA NA hsa-miR-196b-5p RBMS3 1.85699053895181 0.000944585924552801 -2.00226158386017 2.53710901023109e-11 MirTarget -0.140812342835653 1.17243622758876e-08 NA NA NA hsa-miR-9-5p RBMS3 4.99250901331516 2.59132733422801e-19 -2.00226158386017 2.53710901023109e-11 MirTarget;mirMAP -0.1810239081363 2.26251338478565e-14 NA NA NA hsa-miR-9-5p RCAN2 4.99250901331516 2.59132733422801e-19 -1.25056625605026 1.91859651291872e-05 miRNATAP -0.136119057964744 3.68301445711982e-09 NA NA NA hsa-miR-21-5p RECK 4.38165933891779 1.52536633902505e-92 -1.89897239930422 2.77224959500889e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309783840570466 1.18908872345349e-16 19730150;20480266;22642976;18794849;25720799 Protein levels of tumor suppressor targets of the miRNAs were increased by antisense to miR-21 PTEN and RECK and miR-221 p27;Furthermore we identified that RECK reversion-inducing-cysteine-rich protein with kazal motifs a tumor suppressor gene was a direct target of miR-21; Our results suggest that miR-21 expression has a key role in regulating cellular processes in osteosarcoma likely through regulating RECK and may serve as a therapeutic target;miR 21 may acts as an oncomir by targeting RECK a matrix metalloproteinase regulator in prostate cancer; The micro RNA miRNA mir-21 has been shown to regulate invasiveness in cancer through translational repression of the Metaloproteinase MMP inhibitor RECK; Our aim is to investigate the levels of expression of RECK and miR-21 in PCa comparing with classical prognostic factors and disease outcome and also test if RECK is a target of miR-21 in in vitro study using PCa cell line; To determine if RECK is a target of miR-21 in prostate cancer we performed an in vitro assay with PCa cell line DU-145 transfected with pre-miR-21 and anti-miR-21; To determine miR-21 and RECK expression levels in PCa samples we performed quantitative real-time polymerase chain reaction qRT-PCR; From men who presented the second profile miR-21 overexpression and RECK underexpression 91.7% were staged pT3; Our results demonstrate RECK as a target of miR-21; We believe that miR-21 may be important in PCa progression through its regulation of RECK a known regulator of tumor cell invasion;Finally we showed that RECK a known tumor suppressor in gastric cancer is a bona fide target of miR-21; Taken together miR-21 may be important in the initiation and progression of gastric cancers as an oncomiR likely through regulating RECK; Our findings suggest a potential regulatory pathway in which H pylori infection upregulates expression of miR-21 which in turn downregulates RECK and then leads to the development of gastric cancer;We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression ;;staging;progression;progression;metastasis;progression pancreatic cancer;sarcoma;prostate cancer;gastric cancer;liver cancer hsa-miR-9-5p REPS2 4.99250901331516 2.59132733422801e-19 -1.34306421780115 1.84108827536644e-08 mirMAP -0.157802424214927 2.07976751026881e-17 NA NA NA hsa-miR-21-5p REV3L 4.38165933891779 1.52536633902505e-92 -1.03411264073524 6.47927049007671e-11 miRNAWalker2_validate -0.21628345780001 3.72426365060405e-15 NA NA NA hsa-miR-21-5p RHOB 4.38165933891779 1.52536633902505e-92 -0.816440724935267 0.000691602560764595 miRNAWalker2_validate;miRTarBase;miRNATAP -0.111372159234376 0.00861644941281711 21872591;25861727 miR 21 targets the tumor suppressor RhoB and regulates proliferation invasion and apoptosis in colorectal cancer cells; Here we show that expression of miR-21 in HEK293 and several colorectal cancer cells was found inversely correlated with ras homolog gene family member B RhoB expression; miR-21 expression significantly suppressed RhoB 3' UTR luciferase-reporter activity but the inhibitory effect was lost when the putative target sites were mutated; Exogenous miR-21 over-expression mimicked the effect of RhoB knockdown in promoting proliferation and invasion and inhibiting apoptosis whereas anti-miR-21 or RhoB expression yielded opposite effects in colorectal cancer cells; These results suggest that miR-21 is a regulator of RhoB expression and RhoB could be a useful target in exploring the potential therapeutic benefits of miR-21 mediated tumor cell behaviors in colorectal cancer;Here we demonstrate that intravenously-administered chlorotoxin CTX-coupled targeted stable nucleic acid lipid particle SNALP-formulated anti-miR-21 oligonucleotides accumulate preferentially within brain tumors and promote efficient miR-21 silencing which results in increased mRNA and protein levels of its target RhoB while showing no signs of systemic immunogenicity ; colorectal cancer;glioblastoma hsa-miR-9-5p RHOJ 4.99250901331516 2.59132733422801e-19 -2.19273544930557 2.0138846016026e-26 miRNATAP -0.132647861320155 3.23402837305147e-15 NA NA NA hsa-miR-21-5p RNF11 4.38165933891779 1.52536633902505e-92 -0.636472731489344 1.28542744699403e-09 miRNAWalker2_validate -0.101872207367856 3.10412607804535e-08 NA NA NA hsa-miR-9-5p RNF128 4.99250901331516 2.59132733422801e-19 -1.62438370449089 0.00068222782970127 MirTarget;miRNATAP -0.111348464523776 0.00350265736882168 NA NA NA hsa-miR-21-5p RNF182 4.38165933891779 1.52536633902505e-92 -3.08551118428445 1.8472122878934e-14 MirTarget -0.652464541448685 8.70850966408891e-21 NA NA NA hsa-miR-21-5p ROR1 4.38165933891779 1.52536633902505e-92 -2.44635991699964 2.47189577870697e-13 miRNATAP -0.415140630708518 1.78352700134701e-12 NA NA NA hsa-miR-9-5p RORA 4.99250901331516 2.59132733422801e-19 -1.38443392547041 3.0515491681973e-10 mirMAP;miRNATAP -0.140321932939071 4.03911535364344e-16 NA NA NA hsa-miR-21-5p RP2 4.38165933891779 1.52536633902505e-92 -0.760676319005115 9.2768298995899e-09 miRNAWalker2_validate;miRNATAP -0.146773584097415 2.20660724627261e-10 NA NA NA hsa-miR-9-5p RPS6KA2 4.99250901331516 2.59132733422801e-19 -1.04343331479045 1.62125928478786e-06 miRNATAP -0.130728183864576 1.3447378269276e-14 NA NA NA hsa-miR-21-5p RRAGC 4.38165933891779 1.52536633902505e-92 -0.544879874694469 0.000144329383576707 miRNAWalker2_validate -0.10140092602852 5.42288008269315e-05 NA NA NA hsa-miR-196b-5p RSPO2 1.85699053895181 0.000944585924552801 -4.15350636502194 3.01988137709938e-14 MirTarget;miRNATAP -0.260532717503248 8.79438809537104e-09 NA NA NA hsa-miR-21-5p RTKN2 4.38165933891779 1.52536633902505e-92 -4.23491297660768 6.74970506814765e-38 MirTarget -0.648768224578091 6.11689459510285e-28 NA NA NA hsa-miR-9-5p RTN4RL1 4.99250901331516 2.59132733422801e-19 -2.134226374662 2.69838358836131e-06 MirTarget -0.214143594657023 2.57403052557622e-09 NA NA NA hsa-miR-9-5p RUNX1T1 4.99250901331516 2.59132733422801e-19 -1.82449256960527 3.90438288864204e-08 mirMAP;miRNATAP -0.124422975155331 2.75731170992568e-06 NA NA NA hsa-miR-21-5p SACM1L 4.38165933891779 1.52536633902505e-92 -0.839315427297113 4.71765201254009e-13 miRNAWalker2_validate -0.161858129121206 1.09448092706257e-15 NA NA NA hsa-miR-21-5p SAMD5 4.38165933891779 1.52536633902505e-92 -1.85255936795675 1.50494062358682e-07 miRNAWalker2_validate -0.394773366064795 1.45704228189025e-10 NA NA NA hsa-miR-21-5p SASH1 4.38165933891779 1.52536633902505e-92 -1.96585889323898 4.79752785773708e-27 miRNAWalker2_validate;MirTarget -0.35898881068606 2.01602563789895e-29 NA NA NA hsa-miR-21-5p SATB1 4.38165933891779 1.52536633902505e-92 -1.03880379282265 8.58789344949078e-06 MirTarget;miRNATAP -0.255446787676418 3.12717687320813e-10 27107063 SATB1 is Down regulated in Clear Cell Renal Cell Carcinoma and Correlates with miR 21 5p Overexpression and Poor Prognosis; This study aimed to determine the expression levels of SATB1 as well as miR-21-5p -the post-transcriptional repressor of SATB1 expression- in clear cell renal cell carcinoma ccRCC and to investigate their association with the progression of ccRCC; Immunohistochemistry and quantitative polymerase chain reaction were used to assess the expression of SATB1 protein and mRNA as well as miR-21-5p in tumor and matched normal kidney tissues collected from 56 ccRCC patients; SATB1 mRNA level was down-regulated in ccRCC tissue and inversely correlated with the content of miR-21-5p; Down-regulation of SATB1 mRNA and up-regulation of miR-21-5p were associated with shorter patient survival; Decreased expression of SATB1 in ccRCC may result from over-expressed miR-21-5p worse prognosis;progression;poor survival kidney renal cell cancer hsa-miR-9-5p SCN2B 4.99250901331516 2.59132733422801e-19 -2.82021622286963 5.5334153862572e-12 miRNATAP -0.223416277986856 7.05597890606191e-12 NA NA NA hsa-miR-9-5p SCUBE2 4.99250901331516 2.59132733422801e-19 -1.16086357337131 0.0107699380867186 MirTarget -0.209533351919522 4.40913721750521e-09 NA NA NA hsa-miR-21-5p SEC14L5 4.38165933891779 1.52536633902505e-92 -0.0940810125059832 0.772455007523982 mirMAP -0.159493489717711 0.0051213968896845 NA NA NA hsa-miR-21-5p SEC22C 4.38165933891779 1.52536633902505e-92 -0.779552410674588 6.31348998201007e-16 mirMAP -0.105685146779367 6.32853161311929e-10 NA NA NA hsa-miR-21-5p SEMA5A 4.38165933891779 1.52536633902505e-92 -2.93236171912431 7.07249268215627e-21 miRNAWalker2_validate -0.472327459454595 1.60931373128733e-17 NA NA NA hsa-miR-9-5p SEMA6D 4.99250901331516 2.59132733422801e-19 -2.80890333405802 1.12819674911885e-16 mirMAP;miRNATAP -0.163601639523433 2.48379338298938e-09 NA NA NA hsa-miR-21-5p SESN1 4.38165933891779 1.52536633902505e-92 -1.80580674870285 1.4714514385367e-22 miRNAWalker2_validate -0.347624018205389 2.35349864344463e-27 NA NA NA hsa-miR-21-5p SESTD1 4.38165933891779 1.52536633902505e-92 -0.720152974746013 6.47688584940628e-05 miRNAWalker2_validate;mirMAP -0.145554282739152 4.00747680950512e-06 NA NA NA hsa-miR-9-5p SETBP1 4.99250901331516 2.59132733422801e-19 -1.28360807279456 3.38830168236471e-06 MirTarget;mirMAP -0.112472009464713 2.91468773407512e-07 NA NA NA hsa-miR-21-5p SEZ6L 4.38165933891779 1.52536633902505e-92 -0.901277965363033 0.0514810470615853 miRNATAP -0.275200999046525 0.00068751344753943 NA NA NA hsa-miR-21-5p SGCB 4.38165933891779 1.52536633902505e-92 -1.15227772188264 2.76328051577303e-11 miRNAWalker2_validate -0.22230635449862 1.91179943491579e-13 NA NA NA hsa-miR-9-5p SGCD 4.99250901331516 2.59132733422801e-19 -1.50580144752869 5.97211906870455e-07 mirMAP;miRNATAP -0.118936863477917 7.27152711774047e-07 NA NA NA hsa-miR-9-5p SGMS2 4.99250901331516 2.59132733422801e-19 -1.14826242205563 2.61327773859518e-07 MirTarget;miRNATAP -0.149779627328996 4.54570774894988e-18 NA NA NA hsa-miR-21-5p SH3BGRL2 4.38165933891779 1.52536633902505e-92 -0.35587705228416 0.170205798308592 mirMAP -0.154880664304172 0.000641465390381469 NA NA NA hsa-miR-9-5p SHE 4.99250901331516 2.59132733422801e-19 -1.80013257760198 4.19344113029621e-06 mirMAP -0.272764272913679 1.52403427238982e-19 NA NA NA hsa-miR-9-5p SHISA2 4.99250901331516 2.59132733422801e-19 -1.62027630257899 0.00198535651349396 MirTarget -0.16459396778196 7.54468118155262e-05 NA NA NA hsa-miR-9-5p SHROOM4 4.99250901331516 2.59132733422801e-19 -2.05663813992051 1.67658777305673e-13 MirTarget;miRNATAP -0.221515545077977 1.2237893134377e-24 NA NA NA hsa-miR-21-5p SKI 4.38165933891779 1.52536633902505e-92 -0.735047154029438 2.74103842517755e-08 MirTarget;miRNATAP -0.108258594242648 3.38292186328778e-06 NA NA NA hsa-miR-9-5p SLC14A1 4.99250901331516 2.59132733422801e-19 -2.70935517798037 1.15170172391364e-12 MirTarget -0.224570894005616 1.14624588932758e-13 NA NA NA hsa-miR-21-5p SLC16A10 4.38165933891779 1.52536633902505e-92 -1.00969020650986 0.000283658589174965 miRNAWalker2_validate -0.11206016409015 0.022504957013417 NA NA NA hsa-miR-9-5p SLC1A1 4.99250901331516 2.59132733422801e-19 -2.78809173446077 9.57181307581152e-15 miRNATAP -0.173517646267365 2.24104278678074e-09 NA NA NA hsa-miR-9-5p SLC1A2 4.99250901331516 2.59132733422801e-19 -1.40511738268172 0.000214547968624792 mirMAP -0.102592998880011 0.000696431775604887 NA NA NA hsa-miR-9-5p SLC22A3 4.99250901331516 2.59132733422801e-19 -1.60246889632835 0.000445285358758338 miRNAWalker2_validate -0.285868814784416 5.81500783407291e-16 NA NA NA hsa-miR-21-5p SLC26A2 4.38165933891779 1.52536633902505e-92 -0.830358491210976 0.000551510246040855 miRNAWalker2_validate;mirMAP -0.135705315944899 0.00133023547519835 NA NA NA hsa-miR-9-5p SLCO2B1 4.99250901331516 2.59132733422801e-19 -1.94700378677351 3.36444152617988e-12 MirTarget -0.145420880334051 7.30616880503767e-11 NA NA NA hsa-miR-9-5p SLIT3 4.99250901331516 2.59132733422801e-19 -2.95831703999917 4.1545446622722e-16 mirMAP -0.19634520761156 1.97231636190033e-11 NA NA NA hsa-miR-21-5p SMAD7 4.38165933891779 1.52536633902505e-92 -1.03334261220629 1.40098151909512e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.148016758566167 4.47144478410339e-08 23372687;27185036;26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways ;; breast cancer;lung squamous cell cancer;breast cancer hsa-miR-9-5p SMAD9 4.99250901331516 2.59132733422801e-19 -2.49383634336311 3.38631984097475e-12 mirMAP -0.119051960132985 4.03053681964422e-05 NA NA NA hsa-miR-9-5p SNED1 4.99250901331516 2.59132733422801e-19 -0.425710155071426 0.0634500465429009 mirMAP -0.151083016136524 8.28167952234756e-18 NA NA NA hsa-miR-21-5p SNRK 4.38165933891779 1.52536633902505e-92 -1.22533314113389 3.97626958191335e-25 miRNAWalker2_validate -0.212914964551427 1.04687238569975e-24 NA NA NA hsa-miR-21-5p SNX1 4.38165933891779 1.52536633902505e-92 -0.912994401779325 1.59136375645284e-19 mirMAP -0.172749370262395 6.28435762917039e-23 NA NA NA hsa-miR-9-5p SNX25 4.99250901331516 2.59132733422801e-19 -1.5116764362606 5.62088869998108e-13 MirTarget -0.154392623136018 3.66741672433469e-21 NA NA NA hsa-miR-21-5p SNX29 4.38165933891779 1.52536633902505e-92 -0.585986330976387 3.34044254203439e-05 miRNATAP -0.144520507758042 3.88626829925597e-09 NA NA NA hsa-miR-21-5p SNX30 4.38165933891779 1.52536633902505e-92 -1.48183188404363 5.08976625184815e-09 miRNAWalker2_validate -0.279232966949964 3.31833714251967e-10 NA NA NA hsa-miR-21-5p SOD3 4.38165933891779 1.52536633902505e-92 -1.54287203171626 1.88982462097847e-08 miRNAWalker2_validate;miRTarBase -0.188979311730183 0.000103287942257894 NA NA NA hsa-miR-196b-5p SORCS1 1.85699053895181 0.000944585924552801 -1.12709656436366 0.0222440364625193 miRNATAP -0.162395229934071 5.07912578589091e-05 NA NA NA hsa-miR-21-5p SOX5 4.38165933891779 1.52536633902505e-92 -2.5492927879103 4.38349601252352e-14 miRNAWalker2_validate;miRTarBase;miRNATAP -0.487379943709529 1.5052422125893e-16 NA NA NA hsa-miR-21-5p SOX6 4.38165933891779 1.52536633902505e-92 -0.979926723135707 0.00981448848082569 MirTarget;miRNATAP -0.341907446406189 2.24071759937086e-07 NA NA NA hsa-miR-9-5p SOX6 4.99250901331516 2.59132733422801e-19 -0.979926723135707 0.00981448848082569 mirMAP -0.101810425348169 0.000727601479489195 NA NA NA hsa-miR-21-5p SOX7 4.38165933891779 1.52536633902505e-92 -2.90195741440637 2.62325567308758e-25 miRNATAP -0.483981068029855 1.10820127972869e-22 NA NA NA hsa-miR-21-5p SPATA18 4.38165933891779 1.52536633902505e-92 -2.01857093427311 2.0177368405095e-06 mirMAP -0.44262667990937 2.44829159171408e-09 NA NA NA hsa-miR-21-5p SPEF2 4.38165933891779 1.52536633902505e-92 -0.883053359614232 0.00297413314279959 MirTarget -0.151433580758205 0.0037737581260188 NA NA NA hsa-miR-21-5p SPG20 4.38165933891779 1.52536633902505e-92 -0.922676989979982 1.16239604724988e-10 miRNATAP -0.159953269931121 1.94012064367386e-10 NA NA NA hsa-miR-9-5p SPI1 4.99250901331516 2.59132733422801e-19 -1.78741881510996 2.52264089693164e-12 miRNAWalker2_validate -0.105056148450786 3.20472583336388e-07 NA NA NA hsa-miR-9-5p SPOCK2 4.99250901331516 2.59132733422801e-19 -3.5027849521787 2.28392438238602e-32 mirMAP -0.157530951566193 2.04897830386911e-10 NA NA NA hsa-miR-21-5p SPRY1 4.38165933891779 1.52536633902505e-92 -0.842495704439272 5.61559400130424e-06 miRNATAP -0.169221056632968 1.87839009680652e-07 24155920 Functional studies showed that miR-21 over-expression in GICs induced comparable cell differentiation features and targeted SPRY1 mRNA which encodes for a negative regulator of neural stem-cell differentiation differentiation glioblastoma hsa-miR-21-5p SPRY2 4.38165933891779 1.52536633902505e-92 -0.977623105588266 2.21329948488015e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.15366732752538 3.78204629369481e-06 22322462 Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon tumorigenesis colon cancer hsa-miR-21-5p SPTLC3 4.38165933891779 1.52536633902505e-92 -1.15448596872837 0.00235202181353627 miRNAWalker2_validate -0.212481143172777 0.00144940615773589 NA NA NA hsa-miR-21-5p SSFA2 4.38165933891779 1.52536633902505e-92 -1.25435994913263 2.46433063236663e-15 miRNAWalker2_validate;miRNATAP -0.217575038272501 5.40587370234824e-15 NA NA NA hsa-miR-9-5p ST3GAL1 4.99250901331516 2.59132733422801e-19 -0.524543779382772 0.0432044358994235 mirMAP -0.149785728060296 8.83423841396704e-14 NA NA NA hsa-miR-21-5p ST6GAL1 4.38165933891779 1.52536633902505e-92 -0.22054766368521 0.282656297833439 miRNAWalker2_validate -0.11249388800891 0.00172570786505573 NA NA NA hsa-miR-9-5p STARD13 4.99250901331516 2.59132733422801e-19 -2.17267668212899 1.89697357433159e-30 miRNATAP -0.141005388046259 6.54600043287012e-20 NA NA NA hsa-miR-9-5p STK32A 4.99250901331516 2.59132733422801e-19 1.29941025555309 0.00412922860820051 mirMAP -0.108437228344821 0.002632134827026 NA NA NA hsa-miR-21-5p SV2B 4.38165933891779 1.52536633902505e-92 -1.40951006598753 5.30817206734902e-05 mirMAP -0.364539173405716 1.89527909019506e-09 NA NA NA hsa-miR-9-5p SYNE1 4.99250901331516 2.59132733422801e-19 -1.51993415510001 3.2888765494566e-09 miRNAWalker2_validate -0.162446789527361 6.69989377588342e-16 NA NA NA hsa-miR-21-5p SYT15 4.38165933891779 1.52536633902505e-92 -3.57389172890785 3.35975684837849e-20 MirTarget -0.612721632058166 3.4053887518034e-19 NA NA NA hsa-miR-9-5p TACC1 4.99250901331516 2.59132733422801e-19 -2.05130402316217 4.79729930106458e-24 mirMAP -0.114128157631233 6.08865444742599e-12 NA NA NA hsa-miR-21-5p TAGAP 4.38165933891779 1.52536633902505e-92 -0.804133419665316 0.001667988059941 MirTarget;miRNATAP -0.120485982878268 0.0074542691791481 NA NA NA hsa-miR-21-5p TCF21 4.38165933891779 1.52536633902505e-92 -3.83674457795257 2.07869688173266e-22 miRNAWalker2_validate -0.654218332320424 4.87111884187023e-21 NA NA NA hsa-miR-196b-5p TEF 1.85699053895181 0.000944585924552801 -1.19043506602756 1.93356955076392e-08 mirMAP -0.127189300942949 9.9625538601358e-14 NA NA NA hsa-miR-21-5p TESK2 4.38165933891779 1.52536633902505e-92 -0.639034741020656 3.27683951506407e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.157216682747808 4.17429704685818e-09 NA NA NA hsa-miR-21-5p TGFB2 4.38165933891779 1.52536633902505e-92 -1.54728695593794 7.69099073313309e-06 miRNAWalker2_validate -0.232847735640903 0.000134967329541337 NA NA NA hsa-miR-21-5p TGFBR2 4.38165933891779 1.52536633902505e-92 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRTarBase;miRNATAP -0.29338269527103 7.25339608661878e-16 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-9-5p TGFBR2 4.99250901331516 2.59132733422801e-19 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.172577947355941 5.13696472146911e-27 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-21-5p TGFBR3 4.38165933891779 1.52536633902505e-92 -3.00237515277085 4.40834583299503e-24 miRNAWalker2_validate -0.52936321276773 3.12764271220347e-24 NA NA NA hsa-miR-21-5p THRB 4.38165933891779 1.52536633902505e-92 -1.58961318283314 1.90283447169803e-06 MirTarget;miRNATAP -0.29065251304902 7.1210285685096e-07 21159845 Direct interaction with THRB was shown for miR-21 and miR-146a; We observed lower levels of THRB transcripts in cell lines transfected with miR-21 -146a and -221 down-regulation of 37-48%; P < 0.0001 but not with miR-181a; The analysis of tumor/normal tissue pairs revealed down-regulation of THRB in 11 of 13 pairs 1.3- to 9.1-fold and up-regulation of miR-21 -146a -181a and -221 in almost all pairs thyroid cancer hsa-miR-21-5p TIAM1 4.38165933891779 1.52536633902505e-92 -1.15161178404697 1.76180407652893e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.177500253479744 0.000173004493622405 20826792 miR 21 and miR 31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells; We present compelling evidence that TIAM1 a guanidine exchange factor of the Rac GTPase is a direct target of both miR-21 and miR-31 colon cancer hsa-miR-21-5p TIMP3 4.38165933891779 1.52536633902505e-92 -2.29631053711947 1.46430697909437e-17 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.295699211692005 8.53650160998618e-10 23936642;21820586;25720799;20346171;25587717 Genetic heterogeneity of breast cancer metastasis may be related to miR 21 regulation of TIMP 3 in translation; The aim of this study is to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis promoted breast cancer metastasis by regulating the tissue inhibitor of metalloproteinase 3 TIMP-3 gene; Correlation analysis was performed between miR-21 and TIMP-3; There was significantly inverse correlation between miR-21 and TIMP-3 extracted from tissue;The effect of TIMP3 on miR-21-induced cell survival was determined by transfection with TIMP3 lacking 3' untranslated region and miR-21;We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression;The aim of this study was to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis impacts breast cancer invasion by regulating the tissue inhibitor of metalloproteinase 3 TIMP3 gene; In addition the regulation of tissue inhibitor of metalloproteinase 3 TIMP3 by miR-21 was evaluated by western blotting and luciferase assays; Evaluation of TIMP3 protein levels a peptidase involved in extarcellular matrix degredation inversely correlated with miR-21 expression; As knockdown of miR-21 increased TIMP3 protein expression and luciferase reporter activity our data suggests that miR-21 could promote invasion in breast cancer cells via its regulation of TIMP3;It was previously shown by our group that miR-21 a potential regulator of TIMP3 is over-expressed in cutaneous melanoma; It was therefore hypothesized that increased levels of miR-21 expression would lead to decreased expression of TIMP3 and thereby enhance the invasiveness of melanoma cells; Reduced expression of TIMP3 was achieved by siRNA knockdown and significantly enhanced invasion of melanoma cell lines mimicking the effects of miR-21 over-expression; Treatment of tumor cells with a linked nucleic acid antagomir to miR-21 inhibited tumor growth and increased tumor expression of TIMP3 in vivo in 01B74 Athymic NCr-nu/nu mice; This data shows that increased expression of miR-21 enhanced the invasive potential of melanoma cell lines through TIMP3 inhibition metastasis;tumorigenesis;poor survival;metastasis;progression;tumorigenesis; breast cancer;kidney renal cell cancer;liver cancer;breast cancer;melanoma hsa-miR-21-5p TLR4 4.38165933891779 1.52536633902505e-92 -2.06259897319771 8.13416542428308e-17 miRNAWalker2_validate -0.310015993716253 1.78751167789183e-12 27286259 For in vivo relevance expression of TLR4 was correlated with miR-21 expression and ROS production in freshly isolated untreated primary human lung cancer cells lung cancer hsa-miR-21-5p TMEM170B 4.38165933891779 1.52536633902505e-92 -0.920721293477001 1.95166533134692e-06 mirMAP -0.212797656122163 2.63399005508718e-10 NA NA NA hsa-miR-21-5p TMEM56 4.38165933891779 1.52536633902505e-92 -0.743248205424807 0.00307283313776113 miRNAWalker2_validate;mirMAP -0.16459789538599 0.00018385814334605 NA NA NA hsa-miR-21-5p TMX4 4.38165933891779 1.52536633902505e-92 -0.272699543180412 0.111791215416004 miRNAWalker2_validate;mirMAP -0.124108989274479 3.25459337125395e-05 NA NA NA hsa-miR-21-5p TNFRSF11B 4.38165933891779 1.52536633902505e-92 -0.737099733237779 0.0282451381642891 miRNAWalker2_validate -0.228645305978608 9.97304309169901e-05 NA NA NA hsa-miR-9-5p TNS1 4.99250901331516 2.59132733422801e-19 -2.40766853418748 3.89386501566552e-25 mirMAP -0.189076979879493 1.77163463207676e-24 NA NA NA hsa-miR-21-5p TNS3 4.38165933891779 1.52536633902505e-92 -1.2130009541022 1.59991857922078e-13 miRNAWalker2_validate -0.173111853635148 2.86930225949393e-09 NA NA NA hsa-miR-9-5p TPK1 4.99250901331516 2.59132733422801e-19 -1.37087414931144 4.94294325997285e-09 MirTarget -0.162929418679186 3.45000808021777e-19 NA NA NA hsa-miR-9-5p TSPAN18 4.99250901331516 2.59132733422801e-19 -2.2037109732912 4.32197833752292e-20 mirMAP -0.111885175640499 1.17969661575277e-08 NA NA NA hsa-miR-9-5p TTC28 4.99250901331516 2.59132733422801e-19 -1.42248413493077 2.90845279692568e-14 mirMAP -0.118544956867596 1.28114019225038e-15 NA NA NA hsa-miR-21-5p TTC33 4.38165933891779 1.52536633902505e-92 -0.439686284536777 0.000969233535448681 miRNAWalker2_validate -0.110507482882076 1.93569218839059e-06 NA NA NA hsa-miR-21-5p UBASH3B 4.38165933891779 1.52536633902505e-92 -1.97610022517659 4.04999620030904e-13 mirMAP -0.262085868035342 6.45519197237911e-08 NA NA NA hsa-miR-21-5p UTRN 4.38165933891779 1.52536633902505e-92 -1.63420349573468 1.09071510851656e-19 miRNAWalker2_validate -0.275495684581486 3.77767101480513e-18 NA NA NA hsa-miR-21-5p VPS36 4.38165933891779 1.52536633902505e-92 -0.423920794354819 0.000204543717111589 miRNAWalker2_validate -0.107622626245913 5.63235274259647e-08 NA NA NA hsa-miR-21-5p VSNL1 4.38165933891779 1.52536633902505e-92 -1.30923727792323 0.00153944843628888 MirTarget -0.184088525789105 0.0115060081124519 NA NA NA hsa-miR-9-5p WDFY4 4.99250901331516 2.59132733422801e-19 -1.2116405729724 0.000190245318458511 mirMAP -0.136317361986194 1.06381454346715e-07 NA NA NA hsa-miR-21-5p WDR7 4.38165933891779 1.52536633902505e-92 -0.625584542799406 2.57851969861529e-07 miRNAWalker2_validate -0.142432588682261 1.33744747744095e-11 NA NA NA hsa-miR-21-5p WFS1 4.38165933891779 1.52536633902505e-92 -1.77897704339807 5.56839583352296e-25 miRNAWalker2_validate -0.240474621615804 8.57271545149902e-15 NA NA NA hsa-miR-9-5p WNT3A 4.99250901331516 2.59132733422801e-19 -5.44957058224664 2.48610908209879e-25 mirMAP -0.213620822045756 9.54678202540892e-07 NA NA NA hsa-miR-21-5p WWC2 4.38165933891779 1.52536633902505e-92 -2.41920218173621 6.91136590098326e-33 miRNAWalker2_validate -0.362186697904208 2.37230786787255e-23 NA NA NA hsa-miR-21-5p XPO4 4.38165933891779 1.52536633902505e-92 -0.820711686383273 3.80456355653831e-12 mirMAP -0.143611736990512 3.98308563178046e-12 NA NA NA hsa-miR-9-5p ZBTB4 4.99250901331516 2.59132733422801e-19 -1.02633830171063 3.24738601086358e-14 miRNATAP -0.104879661459267 1.71071487573923e-23 NA NA NA hsa-miR-21-5p ZBTB47 4.38165933891779 1.52536633902505e-92 -1.21990762159089 9.38057244550895e-17 miRNAWalker2_validate -0.129098984423471 9.74329649344378e-07 NA NA NA hsa-miR-9-5p ZEB2 4.99250901331516 2.59132733422801e-19 -1.6866832730398 4.28557525993656e-15 MirTarget -0.119130123515025 4.54362927206006e-12 NA NA NA hsa-miR-196b-5p ZNF385B 1.85699053895181 0.000944585924552801 -3.47419980410087 7.7410828427632e-10 MirTarget;miRNATAP -0.3461299213215 3.74018154118456e-14 NA NA NA hsa-miR-9-5p ZNF662 4.99250901331516 2.59132733422801e-19 -0.874691739044908 0.00484261761085368 MirTarget -0.110557293359445 6.6665401752952e-06 NA NA NA hsa-miR-21-5p ZNF704 4.38165933891779 1.52536633902505e-92 -1.31546220210418 3.77547708108009e-06 MirTarget;miRNATAP -0.299652509616392 1.55473940555982e-09 NA NA NA