miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-3p AKT2 0.239865279324672 0.00721479815526816 -0.340477996057433 3.62402949162022e-08 MirTarget -0.103250394013056 0.00819845290941259 NA NA NA hsa-miR-140-5p AKT2 0.504309496243674 3.09884038729031e-11 -0.340477996057433 3.62402949162022e-08 mirMAP -0.257894167615696 4.25294111137846e-09 NA NA NA hsa-miR-193a-3p AKT2 0.849206638484406 3.68101781083335e-14 -0.340477996057433 3.62402949162022e-08 miRanda -0.1602336102543 4.66296866332011e-08 NA NA NA hsa-miR-1976 AKT2 0.343475600930938 0.000360243844871748 -0.340477996057433 3.62402949162022e-08 miRNATAP -0.114100456416688 0.00148676672535644 NA NA NA hsa-miR-21-5p AKT2 2.51462371613332 3.30620591950316e-66 -0.340477996057433 3.62402949162022e-08 miRNAWalker2_validate -0.116002520060245 7.24256492760299e-10 NA NA NA hsa-miR-2355-5p AKT2 1.57515081110162 3.54962327490702e-48 -0.340477996057433 3.62402949162022e-08 mirMAP -0.158007486287123 5.63512797747714e-09 NA NA NA hsa-miR-24-3p AKT2 0.173813044685099 0.00565259443420961 -0.340477996057433 3.62402949162022e-08 mirMAP -0.145738275793208 0.0095430051404417 NA NA NA hsa-miR-330-5p AKT2 1.44960468659754 2.12131210588035e-45 -0.340477996057433 3.62402949162022e-08 miRanda -0.199850402161812 2.39463482226386e-12 NA NA NA hsa-miR-338-3p AKT2 0.906250377628867 2.76970900371139e-15 -0.340477996057433 3.62402949162022e-08 mirMAP -0.160942202850334 1.55482491354725e-08 NA NA NA hsa-miR-342-3p AKT2 1.4124432570595 1.07208971556131e-28 -0.340477996057433 3.62402949162022e-08 mirMAP -0.193694719446483 5.5338386148732e-16 NA NA NA hsa-miR-423-3p AKT2 0.460506077888547 3.44680149368459e-09 -0.340477996057433 3.62402949162022e-08 miRNAWalker2_validate -0.134093002116074 0.00224236224837297 NA NA NA hsa-miR-106b-5p AKT3 1.07509411417907 2.11739194181878e-36 -0.243988630870274 0.0117503955413685 miRNATAP -0.362551297020254 3.77551886386752e-11 NA NA NA hsa-miR-107 AKT3 0.140046250553248 0.0943611632552367 -0.243988630870274 0.0117503955413685 PITA;miRanda -0.284787420850406 8.53745778311515e-06 NA NA NA hsa-miR-146b-5p AKT3 1.40714170253819 2.9559871816487e-12 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate -0.106480044558668 2.77668665683102e-05 NA NA NA hsa-miR-15a-5p AKT3 1.42663930007845 1.36006952074963e-57 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate;miRTarBase;miRNATAP -0.209553352701426 2.74861510149098e-05 NA NA NA hsa-miR-15b-5p AKT3 0.773001494057531 1.71784656078957e-16 -0.243988630870274 0.0117503955413685 miRNATAP -0.179137071242714 0.00102312999530003 NA NA NA hsa-miR-16-5p AKT3 0.934012514027655 4.85417898318515e-24 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate;miRTarBase;miRNATAP -0.174740148583929 0.00122158424330689 NA NA NA hsa-miR-17-3p AKT3 0.723795600017259 5.90151677164931e-18 -0.243988630870274 0.0117503955413685 miRNATAP -0.202376849787589 0.00088737719875351 NA NA NA hsa-miR-17-5p AKT3 0.494260110870015 3.8348005261e-09 -0.243988630870274 0.0117503955413685 TargetScan;miRNATAP -0.190824149294487 0.00237163147001594 NA NA NA hsa-miR-22-3p AKT3 0.198460552200729 0.00761005672059428 -0.243988630870274 0.0117503955413685 miRNATAP -0.407589872687642 1.12041867452881e-08 NA NA NA hsa-miR-29a-3p AKT3 -0.431613225927952 4.10166815070288e-08 -0.243988630870274 0.0117503955413685 miRNATAP -0.244491422189309 0.000269689815704259 NA NA NA hsa-miR-29b-3p AKT3 -0.228125979913806 0.0271621721891603 -0.243988630870274 0.0117503955413685 miRNATAP -0.247981734385757 1.40066355236384e-06 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-374b-5p AKT3 0.0804104684417872 0.365593963035077 -0.243988630870274 0.0117503955413685 mirMAP -0.250536892298211 3.33662467499594e-05 NA NA NA hsa-miR-421 AKT3 0.313155739887734 0.020433534776003 -0.243988630870274 0.0117503955413685 miRanda;mirMAP -0.144627984206661 0.000385343212972084 NA NA NA hsa-miR-542-3p AKT3 0.431147917094433 0.000254981247606435 -0.243988630870274 0.0117503955413685 miRanda -0.173551255334696 0.000111564350795738 NA NA NA hsa-miR-616-5p AKT3 0.913426384742148 3.78418389333709e-09 -0.243988630870274 0.0117503955413685 mirMAP -0.172749202880246 3.16635692442533e-07 NA NA NA hsa-miR-93-5p AKT3 1.37365940377595 2.37567548683245e-46 -0.243988630870274 0.0117503955413685 miRNATAP -0.172188027294336 0.000349761294454902 NA NA NA hsa-miR-126-5p CASP9 0.785607261431085 5.77058629454465e-13 -0.640493643795454 4.84619402433504e-23 MirTarget -0.209827969339424 2.33512843630455e-10 NA NA NA hsa-miR-130b-5p CASP9 0.92990617673277 3.75880436852717e-12 -0.640493643795454 4.84619402433504e-23 mirMAP -0.133542104018384 1.00105836546299e-06 NA NA NA hsa-miR-140-5p CASP9 0.504309496243674 3.09884038729031e-11 -0.640493643795454 4.84619402433504e-23 miRanda -0.223105511125259 5.15163770332575e-06 NA NA NA hsa-miR-15a-5p CASP9 1.42663930007845 1.36006952074963e-57 -0.640493643795454 4.84619402433504e-23 mirMAP -0.233625908587689 2.44769264872863e-11 NA NA NA hsa-miR-15b-5p CASP9 0.773001494057531 1.71784656078957e-16 -0.640493643795454 4.84619402433504e-23 mirMAP -0.134379770025843 0.00056125692133512 NA NA NA hsa-miR-16-5p CASP9 0.934012514027655 4.85417898318515e-24 -0.640493643795454 4.84619402433504e-23 mirMAP -0.248606565461915 4.07153687129857e-11 NA NA NA hsa-miR-17-5p CASP9 0.494260110870015 3.8348005261e-09 -0.640493643795454 4.84619402433504e-23 TargetScan -0.125797566438446 0.00510774359125448 NA NA NA hsa-miR-186-5p CASP9 0.507217561043443 9.04455748270995e-10 -0.640493643795454 4.84619402433504e-23 mirMAP -0.146721856991177 0.00121342804051267 NA NA NA hsa-miR-342-5p CASP9 1.37011183051517 4.99462376051624e-28 -0.640493643795454 4.84619402433504e-23 MirTarget -0.152515106474698 3.45836685797776e-08 NA NA NA hsa-miR-590-3p CASP9 1.13702599385212 3.53435739887793e-22 -0.640493643795454 4.84619402433504e-23 miRanda -0.159671085910094 1.12473604347217e-07 NA NA NA hsa-miR-106b-5p CHP2 1.07509411417907 2.11739194181878e-36 -4.85824590499015 3.05626798767572e-58 MirTarget -1.58995368270032 4.17510489844563e-15 NA NA NA hsa-miR-17-5p CHP2 0.494260110870015 3.8348005261e-09 -4.85824590499015 3.05626798767572e-58 MirTarget -1.05293982395628 6.26552263101198e-06 NA NA NA hsa-miR-20a-5p CHP2 0.702602695798242 4.06372887613329e-13 -4.85824590499015 3.05626798767572e-58 MirTarget -1.26631554399921 8.83278262712219e-11 NA NA NA hsa-miR-224-5p CHP2 2.84654230414912 3.0480927226395e-47 -4.85824590499015 3.05626798767572e-58 MirTarget -0.806037485399145 6.26769397013649e-23 NA NA NA hsa-miR-320a CHP2 0.412740558379182 2.02929519701706e-05 -4.85824590499015 3.05626798767572e-58 miRanda -0.731704395825421 0.000358100930886103 NA NA NA hsa-miR-93-5p CHP2 1.37365940377595 2.37567548683245e-46 -4.85824590499015 3.05626798767572e-58 MirTarget -1.74045083301575 3.782182814463e-25 NA NA NA hsa-miR-940 JMJD7-PLA2G4B -0.160421460715008 0.279016637176929 0.151094662027853 0.188937979716058 miRNATAP -0.163357602541697 0.000249936751053691 NA NA NA hsa-miR-149-5p KDR -1.95790336710741 8.46371715052367e-27 0.985118895051475 1.02914063123208e-08 miRNATAP -0.285208531235896 2.71184164647722e-09 NA NA NA hsa-miR-200b-3p KDR -1.70383252137161 2.38979336321755e-30 0.985118895051475 1.02914063123208e-08 miRNAWalker2_validate;miRTarBase;TargetScan -0.27162342475752 3.81432938994288e-06 NA NA NA hsa-miR-200c-3p KDR -5.40303134829523 2.74173143360645e-94 0.985118895051475 1.02914063123208e-08 miRNATAP -0.193548659793197 5.20778982168023e-13 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-335-5p KDR -2.09515619961552 1.03765771499548e-25 0.985118895051475 1.02914063123208e-08 miRNAWalker2_validate -0.236883657749445 1.08371410170902e-07 NA NA NA hsa-miR-429 KDR -2.16569233119434 2.66862243626443e-37 0.985118895051475 1.02914063123208e-08 PITA;miRanda;miRNATAP -0.202657874192441 6.11847457705003e-05 NA NA NA hsa-let-7a-3p KRAS 0.0677487960013088 0.460458477653989 -0.255817061539648 9.1459633191595e-05 mirMAP;miRNATAP -0.135776810220158 0.000642882403233645 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-miR-140-3p KRAS 0.989350547007025 6.14964028267239e-25 -0.255817061539648 9.1459633191595e-05 MirTarget -0.108294077444579 0.00207293957432564 NA NA NA hsa-miR-193a-3p KRAS 0.849206638484406 3.68101781083335e-14 -0.255817061539648 9.1459633191595e-05 MirTarget;miRanda;miRNATAP -0.128321272108433 3.45488258543067e-05 NA NA NA hsa-miR-193a-5p KRAS 1.29777740059595 2.16815694068336e-39 -0.255817061539648 9.1459633191595e-05 miRNATAP -0.131260938035955 4.98455580646047e-05 NA NA NA hsa-miR-27a-3p KRAS 0.558934437526245 1.44256383086177e-12 -0.255817061539648 9.1459633191595e-05 miRNATAP -0.185157688434118 3.18082458260436e-05 24154848;25436011 microRNA 27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS; Furthermore we demonstrated that miR-27a binds to the 3'-untranslated region UTR of KRAS and inhibits the expression of the KRAS protein; miR-27a levels were inversely correlated with levels of KRAS mRNA and protein in ESCC specimens; Our findings suggest for the first time that miR-27a suppresses tumorigenesis of ESCC by targeting KRAS;MicroRNA 27a directly targets KRAS to inhibit cell proliferation in esophageal squamous cell carcinoma; However the expression level of the target gene KRAS was upregulated and ESCC cell proliferation was significantly inhibited following miR-27a mimic or small interfering K-ras transfection; In conclusion the present study demonstrated that the expression level of miR-27a was low in ESCC and that miR-27a directly targets the KRAS gene resulting in inhibited cell proliferation in esophageal cancer tumorigenesis; esophageal cancer;esophageal cancer hsa-miR-542-3p KRAS 0.431147917094433 0.000254981247606435 -0.255817061539648 9.1459633191595e-05 miRanda -0.102463772502373 0.00079256513841055 NA NA NA hsa-let-7a-3p MAPK1 0.0677487960013088 0.460458477653989 0.0752350253994916 0.244227817396104 mirMAP -0.120937214673988 0.00189910022756462 NA NA NA hsa-miR-221-3p MAPK1 0.337895669520713 0.0136448974691037 0.0752350253994916 0.244227817396104 mirMAP -0.18533006750384 1.05774724669662e-13 NA NA NA hsa-miR-222-3p MAPK1 0.214811008033524 0.0965295551752457 0.0752350253994916 0.244227817396104 mirMAP -0.111381984547009 4.49766515770734e-05 NA NA NA hsa-miR-29a-3p MAPK1 -0.431613225927952 4.10166815070288e-08 0.0752350253994916 0.244227817396104 mirMAP -0.199785129647306 6.26938786529944e-06 NA NA NA hsa-miR-29c-3p MAPK1 -0.238671318446745 0.0141475322347596 0.0752350253994916 0.244227817396104 mirMAP -0.118476374132015 0.00117661250325827 NA NA NA hsa-miR-30b-5p MAPK1 -1.18330589477119 6.8341618466966e-27 0.0752350253994916 0.244227817396104 mirMAP -0.126400578163208 1.7728740776704e-05 NA NA NA hsa-miR-24-3p MAPK14 0.173813044685099 0.00565259443420961 -0.1906269679268 0.000282305210520484 miRNAWalker2_validate;miRTarBase;MirTarget -0.144363998896302 0.00209395672973458 NA NA NA hsa-let-7a-3p NFAT5 0.0677487960013088 0.460458477653989 -0.816417557443788 1.77196856943782e-22 MirTarget;mirMAP;miRNATAP -0.251122459345359 2.99362459623734e-06 NA NA NA hsa-let-7b-3p NFAT5 0.239865279324672 0.00721479815526816 -0.816417557443788 1.77196856943782e-22 MirTarget;mirMAP;miRNATAP -0.167290657433056 0.00260582166238805 NA NA NA hsa-let-7f-1-3p NFAT5 0.477913872379336 4.46669616865068e-05 -0.816417557443788 1.77196856943782e-22 MirTarget;mirMAP -0.162111636601771 0.000334878272705912 NA NA NA hsa-miR-103a-3p NFAT5 0.779373475434461 7.37867196796994e-20 -0.816417557443788 1.77196856943782e-22 MirTarget -0.226989037620136 3.12029996215114e-05 NA NA NA hsa-miR-106b-5p NFAT5 1.07509411417907 2.11739194181878e-36 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.473958453484205 2.37145177462699e-22 NA NA NA hsa-miR-107 NFAT5 0.140046250553248 0.0943611632552367 -0.816417557443788 1.77196856943782e-22 MirTarget -0.284279553198954 1.39825835957285e-06 NA NA NA hsa-miR-126-5p NFAT5 0.785607261431085 5.77058629454465e-13 -0.816417557443788 1.77196856943782e-22 MirTarget;mirMAP -0.185794566529228 1.93464514188037e-05 NA NA NA hsa-miR-1301-3p NFAT5 0.393537638993954 0.000390498879474539 -0.816417557443788 1.77196856943782e-22 MirTarget -0.15730957058684 0.000372298957721443 NA NA NA hsa-miR-130b-5p NFAT5 0.92990617673277 3.75880436852717e-12 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.184769053016558 1.48889372928322e-07 NA NA NA hsa-miR-140-3p NFAT5 0.989350547007025 6.14964028267239e-25 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.22534520719281 2.00395668536591e-06 NA NA NA hsa-miR-140-5p NFAT5 0.504309496243674 3.09884038729031e-11 -0.816417557443788 1.77196856943782e-22 PITA;miRNATAP -0.347476077539168 3.06412649638075e-08 NA NA NA hsa-miR-142-5p NFAT5 1.88417391525707 1.2096808039882e-27 -0.816417557443788 1.77196856943782e-22 MirTarget;PITA;miRNATAP -0.200162187507738 1.57471676590964e-15 NA NA NA hsa-miR-143-3p NFAT5 0.544259011512089 1.71102635165867e-05 -0.816417557443788 1.77196856943782e-22 mirMAP -0.156816553769716 4.39791329926318e-05 NA NA NA hsa-miR-146a-5p NFAT5 1.04938133739924 7.51013231709992e-12 -0.816417557443788 1.77196856943782e-22 mirMAP;miRNATAP -0.179867398396589 3.92525390180619e-09 NA NA NA hsa-miR-146b-5p NFAT5 1.40714170253819 2.9559871816487e-12 -0.816417557443788 1.77196856943782e-22 miRanda -0.11829487162396 3.88354455444422e-07 NA NA NA hsa-miR-148a-3p NFAT5 0.343233211643815 0.00402279073598165 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.124866592482946 0.00250376588029971 NA NA NA hsa-miR-148a-5p NFAT5 0.415500302855613 0.000691460831436767 -0.816417557443788 1.77196856943782e-22 mirMAP -0.154809758528918 0.00010684880006692 NA NA NA hsa-miR-148b-3p NFAT5 0.346011252093377 4.27203463315056e-06 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.301816477855443 3.32125256428072e-06 NA NA NA hsa-miR-148b-5p NFAT5 0.269550343699955 0.0383631776794927 -0.816417557443788 1.77196856943782e-22 MirTarget -0.115797102716895 0.00310729655100489 NA NA NA hsa-miR-155-5p NFAT5 3.26274490570809 5.06841441826518e-51 -0.816417557443788 1.77196856943782e-22 mirMAP;miRNATAP -0.153399914764272 9.76022207199999e-17 NA NA NA hsa-miR-15a-5p NFAT5 1.42663930007845 1.36006952074963e-57 -0.816417557443788 1.77196856943782e-22 MirTarget -0.377473568207057 1.47515697050257e-17 NA NA NA hsa-miR-15b-3p NFAT5 1.49422666971434 5.44139893275088e-29 -0.816417557443788 1.77196856943782e-22 mirMAP -0.202041971607595 1.02875661648307e-09 NA NA NA hsa-miR-15b-5p NFAT5 0.773001494057531 1.71784656078957e-16 -0.816417557443788 1.77196856943782e-22 MirTarget -0.241136198150107 1.33553078102364e-06 NA NA NA hsa-miR-16-1-3p NFAT5 1.51429140700091 3.17219833254498e-37 -0.816417557443788 1.77196856943782e-22 mirMAP -0.289416940061869 1.02439287328607e-15 NA NA NA hsa-miR-16-5p NFAT5 0.934012514027655 4.85417898318515e-24 -0.816417557443788 1.77196856943782e-22 MirTarget -0.337389066839677 3.37727375245208e-12 NA NA NA hsa-miR-17-3p NFAT5 0.723795600017259 5.90151677164931e-18 -0.816417557443788 1.77196856943782e-22 mirMAP -0.344914443640037 3.62091701501056e-10 NA NA NA hsa-miR-17-5p NFAT5 0.494260110870015 3.8348005261e-09 -0.816417557443788 1.77196856943782e-22 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.181859753330541 0.00169749612389596 NA NA NA hsa-miR-181a-5p NFAT5 1.11111114875339 3.97880443756442e-29 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.305771219565393 5.37612109782185e-12 NA NA NA hsa-miR-181b-5p NFAT5 1.49054296272357 3.69051660739368e-41 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.302060455365795 9.12597853838058e-16 NA NA NA hsa-miR-186-5p NFAT5 0.507217561043443 9.04455748270995e-10 -0.816417557443788 1.77196856943782e-22 MirTarget;mirMAP -0.324285678163902 1.83640270733673e-08 NA NA NA hsa-miR-18a-5p NFAT5 0.936704393213466 1.05064580570579e-10 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.19721332602987 1.10729342588133e-09 NA NA NA hsa-miR-192-3p NFAT5 0.156650099616707 0.483496040900362 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.136876762351209 2.7601666180186e-10 NA NA NA hsa-miR-193a-3p NFAT5 0.849206638484406 3.68101781083335e-14 -0.816417557443788 1.77196856943782e-22 miRanda -0.278691847393094 1.49487135428537e-11 NA NA NA hsa-miR-194-3p NFAT5 -0.0573594560647068 0.802137112420482 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.101670396908308 2.58594992886226e-06 NA NA NA hsa-miR-194-5p NFAT5 0.62222617402691 0.00659826803316099 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.146005298470987 2.11910566216041e-12 NA NA NA hsa-miR-195-5p NFAT5 0.346502644882604 0.0092562828415903 -0.816417557443788 1.77196856943782e-22 MirTarget -0.218378711497831 1.70435974528423e-09 NA NA NA hsa-miR-21-3p NFAT5 1.78837590049697 1.41655409877312e-33 -0.816417557443788 1.77196856943782e-22 MirTarget -0.212553530979547 2.31677756321625e-13 NA NA NA hsa-miR-21-5p NFAT5 2.51462371613332 3.30620591950316e-66 -0.816417557443788 1.77196856943782e-22 miRNAWalker2_validate;mirMAP -0.247574654543565 7.30559064815237e-22 NA NA NA hsa-miR-224-3p NFAT5 0.918780460857403 2.47005991706282e-07 -0.816417557443788 1.77196856943782e-22 MirTarget -0.112701920966496 5.73626394651817e-05 NA NA NA hsa-miR-224-5p NFAT5 2.84654230414912 3.0480927226395e-47 -0.816417557443788 1.77196856943782e-22 mirMAP -0.135061426543241 1.30762168213107e-10 NA NA NA hsa-miR-2355-3p NFAT5 1.32757890426926 1.88016636795886e-18 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.277842795160608 1.35617318456645e-20 NA NA NA hsa-miR-24-3p NFAT5 0.173813044685099 0.00565259443420961 -0.816417557443788 1.77196856943782e-22 miRNAWalker2_validate;miRNATAP -0.401575492208128 3.65723516019206e-07 NA NA NA hsa-miR-25-3p NFAT5 1.12016166564779 3.79069348635778e-48 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.37542832851899 3.84349761814913e-12 NA NA NA hsa-miR-27a-3p NFAT5 0.558934437526245 1.44256383086177e-12 -0.816417557443788 1.77196856943782e-22 MirTarget -0.420842515213438 1.06725145991906e-12 NA NA NA hsa-miR-32-5p NFAT5 0.407826130035097 7.26884631998646e-06 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.341493954955972 8.82645473577493e-11 NA NA NA hsa-miR-320b NFAT5 0.300497419754843 0.0245219177384172 -0.816417557443788 1.77196856943782e-22 mirMAP -0.119456848415258 0.0012026595083638 NA NA NA hsa-miR-330-3p NFAT5 0.912906550436308 3.35037014057665e-13 -0.816417557443788 1.77196856943782e-22 mirMAP -0.191703168315778 5.69686462366241e-07 NA NA NA hsa-miR-338-5p NFAT5 0.628429807914222 1.27575140717947e-06 -0.816417557443788 1.77196856943782e-22 MirTarget;PITA;mirMAP -0.180783044531869 1.75462074277193e-06 NA NA NA hsa-miR-340-5p NFAT5 1.14479851941741 2.91936881701444e-15 -0.816417557443788 1.77196856943782e-22 MirTarget -0.178489695723996 2.48056825351363e-08 NA NA NA hsa-miR-361-3p NFAT5 1.08992546227594 1.13197240706704e-36 -0.816417557443788 1.77196856943782e-22 MirTarget;PITA;miRNATAP -0.384654962985852 7.2743816956711e-15 NA NA NA hsa-miR-361-5p NFAT5 0.0514169367202078 0.382929376393199 -0.816417557443788 1.77196856943782e-22 MirTarget;PITA;mirMAP;miRNATAP -0.284458777474624 0.000927918191242783 NA NA NA hsa-miR-3613-5p NFAT5 1.6648190889407 3.78720979041391e-41 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.312076764221362 6.11347179992732e-21 NA NA NA hsa-miR-365a-3p NFAT5 0.80809616164259 2.36039522526e-12 -0.816417557443788 1.77196856943782e-22 MirTarget -0.168480254138622 4.3973023269716e-05 NA NA NA hsa-miR-374a-3p NFAT5 1.13863935833993 2.79089304015401e-44 -0.816417557443788 1.77196856943782e-22 mirMAP -0.392645378804653 1.49270892102077e-14 NA NA NA hsa-miR-374a-5p NFAT5 0.543061152108237 2.19403097299769e-14 -0.816417557443788 1.77196856943782e-22 mirMAP;miRNATAP -0.372449132154858 2.03351134775738e-08 NA NA NA hsa-miR-374b-5p NFAT5 0.0804104684417872 0.365593963035077 -0.816417557443788 1.77196856943782e-22 mirMAP;miRNATAP -0.20166729298521 0.0003113618366591 NA NA NA hsa-miR-450b-5p NFAT5 0.404819502355575 0.00357671373841274 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.126955999787477 0.00032238939754855 NA NA NA hsa-miR-452-5p NFAT5 2.05325688842141 2.82238393643084e-40 -0.816417557443788 1.77196856943782e-22 MirTarget -0.202973585000611 7.5541087334292e-14 NA NA NA hsa-miR-497-5p NFAT5 0.227757383708836 0.0600073987853074 -0.816417557443788 1.77196856943782e-22 MirTarget -0.206237759229403 3.12385769411036e-07 NA NA NA hsa-miR-576-5p NFAT5 1.06681109513983 5.69294424466526e-24 -0.816417557443788 1.77196856943782e-22 MirTarget;PITA;mirMAP -0.252927455813257 3.17596100564555e-09 NA NA NA hsa-miR-590-3p NFAT5 1.13702599385212 3.53435739887793e-22 -0.816417557443788 1.77196856943782e-22 MirTarget;miRanda;mirMAP;miRNATAP -0.254564915596959 3.43257778031531e-11 NA NA NA hsa-miR-590-5p NFAT5 0.709763558412506 1.11883921359361e-11 -0.816417557443788 1.77196856943782e-22 PITA;mirMAP;miRNATAP -0.25782820483467 1.07817309318776e-08 NA NA NA hsa-miR-616-5p NFAT5 0.913426384742148 3.78418389333709e-09 -0.816417557443788 1.77196856943782e-22 MirTarget;mirMAP -0.130709708174096 3.15181124028896e-05 NA NA NA hsa-miR-7-1-3p NFAT5 0.544601828025304 5.33830451326047e-07 -0.816417557443788 1.77196856943782e-22 mirMAP -0.168640597733216 0.000160618771418501 NA NA NA hsa-miR-708-3p NFAT5 0.83540388887946 3.55308012540402e-06 -0.816417557443788 1.77196856943782e-22 mirMAP -0.122818293715711 4.32721384567161e-06 NA NA NA hsa-miR-92b-3p NFAT5 0.418630595140165 6.50466149211154e-05 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.155085449452592 0.000914802299673715 NA NA NA hsa-miR-93-5p NFAT5 1.37365940377595 2.37567548683245e-46 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.242199335762023 3.36872210469107e-08 NA NA NA hsa-miR-200b-5p NFATC2 -1.46985752435972 3.43232443788022e-27 0.449362525468644 0.0189141879480816 mirMAP -0.195303131766132 0.00675711085179978 NA NA NA hsa-miR-30b-5p NFATC2 -1.18330589477119 6.8341618466966e-27 0.449362525468644 0.0189141879480816 MirTarget;mirMAP -0.463461325382204 1.11191040571271e-07 NA NA NA hsa-miR-30c-5p NFATC2 -1.08783070774238 2.02505402525786e-24 0.449362525468644 0.0189141879480816 MirTarget;mirMAP -0.271805009769506 0.00325762769077695 NA NA NA hsa-miR-221-3p NFATC3 0.337895669520713 0.0136448974691037 -0.140726285220053 0.0339218322389747 MirTarget;miRNATAP -0.115849278999013 1.12819203212933e-05 NA NA NA hsa-miR-30d-5p NFATC3 -0.202727675788184 0.00659067084745794 -0.140726285220053 0.0339218322389747 MirTarget;miRNATAP -0.140332728977046 0.00452319052730583 NA NA NA hsa-miR-361-5p NFATC3 0.0514169367202078 0.382929376393199 -0.140726285220053 0.0339218322389747 miRanda -0.193117552878382 0.00238037949903394 NA NA NA hsa-miR-29b-3p NFATC4 -0.228125979913806 0.0271621721891603 0.47344681025823 0.000946723727006422 miRNATAP -0.402505484576897 1.23032680444856e-07 NA NA NA hsa-miR-29c-3p NFATC4 -0.238671318446745 0.0141475322347596 0.47344681025823 0.000946723727006422 miRNATAP -0.265114702444064 0.00120757439920213 NA NA NA hsa-miR-3607-3p NFATC4 -0.529788328085356 0.00511771034738625 0.47344681025823 0.000946723727006422 miRNATAP -0.24036070829863 4.41456153455456e-09 NA NA NA hsa-miR-532-5p NFATC4 -1.09700348358668 8.34836230254408e-26 0.47344681025823 0.000946723727006422 mirMAP -0.404648362035331 4.91036144881753e-09 NA NA NA hsa-miR-625-5p NFATC4 0.153090549230629 0.330314026509869 0.47344681025823 0.000946723727006422 mirMAP -0.201502679108411 0.000224845731258786 NA NA NA hsa-miR-629-3p NFATC4 1.09330044556689 2.9533160808356e-14 0.47344681025823 0.000946723727006422 mirMAP -0.150504690909161 0.00533757723845502 NA NA NA hsa-miR-26a-5p NRAS -0.202091714279613 0.00166918288801054 0.34448791512356 4.92740995926564e-07 mirMAP;miRNATAP -0.190676842662057 0.00158798186993403 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-27b-3p NRAS -0.699527231242518 1.07356023759234e-15 0.34448791512356 4.92740995926564e-07 miRNATAP -0.133554182026992 0.00155260770161313 NA NA NA hsa-miR-29a-3p NRAS -0.431613225927952 4.10166815070288e-08 0.34448791512356 4.92740995926564e-07 miRNATAP -0.260252250919602 4.11630497908065e-08 NA NA NA hsa-miR-29c-3p NRAS -0.238671318446745 0.0141475322347596 0.34448791512356 4.92740995926564e-07 miRNATAP -0.171085903480696 1.27586236636451e-05 NA NA NA hsa-miR-502-3p NRAS -1.10416310320528 1.55354569985732e-22 0.34448791512356 4.92740995926564e-07 MirTarget -0.127167715752408 5.47705696881981e-05 NA NA NA hsa-let-7f-1-3p PIK3CA 0.477913872379336 4.46669616865068e-05 -0.342309377518198 0.000115361959187206 mirMAP -0.117169302105272 0.00980511224865979 NA NA NA hsa-miR-148a-5p PIK3CA 0.415500302855613 0.000691460831436767 -0.342309377518198 0.000115361959187206 mirMAP -0.127137756769153 0.00150846590255829 NA NA NA hsa-miR-320b PIK3CA 0.300497419754843 0.0245219177384172 -0.342309377518198 0.000115361959187206 miRanda -0.109684919459557 0.00295331979925903 NA NA NA hsa-miR-339-5p PIK3CA 0.322848334531193 0.0117281778821612 -0.342309377518198 0.000115361959187206 miRanda -0.156390103299638 4.31357238138231e-05 NA NA NA hsa-miR-590-3p PIK3CA 1.13702599385212 3.53435739887793e-22 -0.342309377518198 0.000115361959187206 miRanda;mirMAP -0.167970910292111 1.76355187639927e-05 NA NA NA hsa-miR-590-5p PIK3CA 0.709763558412506 1.11883921359361e-11 -0.342309377518198 0.000115361959187206 miRanda -0.179027916238388 8.77558290901021e-05 NA NA NA hsa-miR-130b-3p PIK3CB 1.12788913578446 2.939369462276e-16 -0.247995112719303 0.00148503458375338 miRNATAP -0.166034631736904 1.58184303321712e-08 NA NA NA hsa-miR-19a-3p PIK3CB 0.722913586880779 2.76301458932381e-10 -0.247995112719303 0.00148503458375338 miRNATAP -0.138948641019506 0.000146950619817948 NA NA NA hsa-miR-19b-3p PIK3CB 0.195940928879427 0.0300512922542325 -0.247995112719303 0.00148503458375338 miRNATAP -0.155249167038679 0.00123255333914152 NA NA NA hsa-miR-25-3p PIK3CB 1.12016166564779 3.79069348635778e-48 -0.247995112719303 0.00148503458375338 miRNATAP -0.168848015389201 0.000511445370430535 NA NA NA hsa-miR-590-3p PIK3CB 1.13702599385212 3.53435739887793e-22 -0.247995112719303 0.00148503458375338 miRNATAP -0.152204162601648 8.6055969781532e-06 NA NA NA hsa-miR-92b-3p PIK3CB 0.418630595140165 6.50466149211154e-05 -0.247995112719303 0.00148503458375338 miRNATAP -0.132204554754912 0.00123182058684873 NA NA NA hsa-miR-10b-5p PIK3CD -0.89971464210447 1.18190532299934e-20 0.827862115800704 6.93199253004924e-19 miRNAWalker2_validate -0.322882758324939 5.32986923354336e-10 NA NA NA hsa-miR-1468-5p PIK3CD -0.311126383179539 0.00979113361106863 0.827862115800704 6.93199253004924e-19 MirTarget -0.200155097962759 8.08016260976088e-06 NA NA NA hsa-miR-30a-5p PIK3CD -0.778411951775343 2.73322451127932e-16 0.827862115800704 6.93199253004924e-19 miRNAWalker2_validate;MirTarget;miRNATAP -0.206007694378125 0.000161176631172019 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30b-3p PIK3CD -1.64703050862226 1.89878531036464e-31 0.827862115800704 6.93199253004924e-19 MirTarget -0.256459682857462 3.84122966933957e-14 NA NA NA hsa-miR-30b-5p PIK3CD -1.18330589477119 6.8341618466966e-27 0.827862115800704 6.93199253004924e-19 MirTarget -0.212463225121162 2.43792629370427e-06 NA NA NA hsa-miR-30c-5p PIK3CD -1.08783070774238 2.02505402525786e-24 0.827862115800704 6.93199253004924e-19 MirTarget;miRNATAP -0.191697315876392 4.85249073283528e-05 NA NA NA hsa-miR-30d-5p PIK3CD -0.202727675788184 0.00659067084745794 0.827862115800704 6.93199253004924e-19 MirTarget;miRNATAP -0.209303428523125 0.00450077920142443 NA NA NA hsa-miR-106b-5p PIK3R1 1.07509411417907 2.11739194181878e-36 -0.234314125271815 0.0111750886765385 MirTarget;miRNATAP -0.179369079303185 0.000816789511004284 NA NA NA hsa-miR-221-3p PIK3R1 0.337895669520713 0.0136448974691037 -0.234314125271815 0.0111750886765385 MirTarget -0.163462882563838 9.21701112965761e-06 NA NA NA hsa-miR-222-3p PIK3R1 0.214811008033524 0.0965295551752457 -0.234314125271815 0.0111750886765385 MirTarget -0.107248741245045 0.00671314109485487 NA NA NA hsa-miR-590-3p PIK3R1 1.13702599385212 3.53435739887793e-22 -0.234314125271815 0.0111750886765385 miRanda;mirMAP -0.106905404095112 0.00880343764678398 NA NA NA hsa-miR-182-5p PIK3R3 -0.608710746044567 0.0025264935278104 0.439819702071113 8.25824839758606e-05 mirMAP -0.153374534942348 3.96734579923425e-07 NA NA NA hsa-miR-339-5p PIK3R3 0.322848334531193 0.0117281778821612 0.439819702071113 8.25824839758606e-05 MirTarget;miRanda -0.192609585710903 6.48743953207512e-05 NA NA NA hsa-miR-365a-3p PIK3R3 0.80809616164259 2.36039522526e-12 0.439819702071113 8.25824839758606e-05 MirTarget -0.16533292375838 0.00153486106521956 NA NA NA hsa-miR-96-5p PIK3R3 -1.00223771166604 3.91564621567028e-06 0.439819702071113 8.25824839758606e-05 mirMAP -0.164731670984697 7.78245878052581e-09 NA NA NA hsa-miR-125a-3p PIK3R5 -0.372794471295036 0.000941729459601642 3.18542758418586 6.04695754116875e-70 miRanda -0.407465916624748 0.000192324867439568 NA NA NA hsa-miR-125a-5p PIK3R5 -0.561874059994802 7.3931856356891e-13 3.18542758418586 6.04695754116875e-70 MirTarget;miRanda -1.34358622921882 2.31129700790236e-20 NA NA NA hsa-miR-125b-5p PIK3R5 -0.825456421494266 2.13029877878434e-15 3.18542758418586 6.04695754116875e-70 MirTarget -0.67295054872876 1.75325492827967e-09 NA NA NA hsa-miR-615-3p PIK3R5 -0.777370544471479 2.08193713560545e-08 3.18542758418586 6.04695754116875e-70 miRanda -0.258205105771951 0.00312779262258178 NA NA NA hsa-miR-106b-5p PLA2G12A 1.07509411417907 2.11739194181878e-36 -0.398969072863746 5.55717944273617e-08 mirMAP -0.318990060549306 2.29217198651414e-14 NA NA NA hsa-miR-140-5p PLA2G12A 0.504309496243674 3.09884038729031e-11 -0.398969072863746 5.55717944273617e-08 miRanda -0.188599257543893 0.000382484546134811 NA NA NA hsa-miR-142-5p PLA2G12A 1.88417391525707 1.2096808039882e-27 -0.398969072863746 5.55717944273617e-08 mirMAP -0.138073144669251 9.04790839331805e-11 NA NA NA hsa-miR-150-5p PLA2G12A 1.00371863159681 1.09871676395528e-09 -0.398969072863746 5.55717944273617e-08 mirMAP -0.14806285256437 5.07167045463163e-10 NA NA NA hsa-miR-16-2-3p PLA2G12A 1.3046118743965 4.17207934608428e-19 -0.398969072863746 5.55717944273617e-08 mirMAP -0.111423414392617 2.54085038058137e-05 NA NA NA hsa-miR-17-3p PLA2G12A 0.723795600017259 5.90151677164931e-18 -0.398969072863746 5.55717944273617e-08 mirMAP -0.246147322379887 1.06111832675154e-07 NA NA NA hsa-miR-17-5p PLA2G12A 0.494260110870015 3.8348005261e-09 -0.398969072863746 5.55717944273617e-08 mirMAP -0.172159927457143 0.000360024830260926 NA NA NA hsa-miR-181a-5p PLA2G12A 1.11111114875339 3.97880443756442e-29 -0.398969072863746 5.55717944273617e-08 mirMAP -0.208596329981168 2.61179244938667e-08 NA NA NA hsa-miR-181b-5p PLA2G12A 1.49054296272357 3.69051660739368e-41 -0.398969072863746 5.55717944273617e-08 mirMAP -0.191772279611356 2.18947515885896e-09 NA NA NA hsa-miR-181c-5p PLA2G12A 0.762784646696248 4.48373118147729e-10 -0.398969072863746 5.55717944273617e-08 mirMAP -0.120873469964364 0.0002220646158873 NA NA NA hsa-miR-186-5p PLA2G12A 0.507217561043443 9.04455748270995e-10 -0.398969072863746 5.55717944273617e-08 mirMAP -0.167023490324012 0.00062699328283718 NA NA NA hsa-miR-20a-5p PLA2G12A 0.702602695798242 4.06372887613329e-13 -0.398969072863746 5.55717944273617e-08 mirMAP -0.131580419112628 0.00139337128447633 NA NA NA hsa-miR-330-3p PLA2G12A 0.912906550436308 3.35037014057665e-13 -0.398969072863746 5.55717944273617e-08 miRNATAP -0.145697955190855 5.6577432220273e-06 NA NA NA hsa-miR-374a-3p PLA2G12A 1.13863935833993 2.79089304015401e-44 -0.398969072863746 5.55717944273617e-08 mirMAP -0.14651878955133 0.000919658365223926 NA NA NA hsa-miR-590-3p PLA2G12A 1.13702599385212 3.53435739887793e-22 -0.398969072863746 5.55717944273617e-08 PITA;miRanda;miRNATAP -0.144365381787861 9.87289711374494e-06 NA NA NA hsa-miR-625-3p PLA2G12A 1.09679549288964 4.60800634006165e-20 -0.398969072863746 5.55717944273617e-08 mirMAP -0.225068546092664 8.61375480674311e-13 NA NA NA hsa-miR-92b-3p PLA2G12A 0.418630595140165 6.50466149211154e-05 -0.398969072863746 5.55717944273617e-08 miRNAWalker2_validate -0.195561990632176 4.06793360999897e-07 NA NA NA hsa-miR-93-5p PLA2G12A 1.37365940377595 2.37567548683245e-46 -0.398969072863746 5.55717944273617e-08 mirMAP -0.163143512838149 9.92914696804009e-06 NA NA NA hsa-miR-30c-2-3p PLA2G2D -1.28402709024345 6.77577627955178e-25 3.25786426267112 1.63883282978629e-21 mirMAP -1.4911913745295 5.06954471302161e-27 NA NA NA hsa-miR-1301-3p PLA2G4A 0.393537638993954 0.000390498879474539 -1.85529407773687 1.9717892081168e-32 MirTarget -0.276077994739491 0.00127728289438848 NA NA NA hsa-miR-142-3p PLA2G4A 1.88928758773299 2.72985643829893e-22 -1.85529407773687 1.9717892081168e-32 miRanda -0.176304107715065 0.000110262875817659 NA NA NA hsa-miR-144-3p PLA2G4A 1.4617706700291 9.18139413836375e-11 -1.85529407773687 1.9717892081168e-32 MirTarget -0.132461250631428 0.00125728302023368 NA NA NA hsa-miR-146b-5p PLA2G4A 1.40714170253819 2.9559871816487e-12 -1.85529407773687 1.9717892081168e-32 miRNAWalker2_validate -0.158304464185306 0.000517342945920931 NA NA NA hsa-miR-181a-5p PLA2G4A 1.11111114875339 3.97880443756442e-29 -1.85529407773687 1.9717892081168e-32 MirTarget -0.547914249646334 2.17897779368898e-10 NA NA NA hsa-miR-181b-5p PLA2G4A 1.49054296272357 3.69051660739368e-41 -1.85529407773687 1.9717892081168e-32 MirTarget -0.580974807139508 1.44687429049341e-15 NA NA NA hsa-miR-181d-5p PLA2G4A 1.00720380524132 6.04219503683814e-14 -1.85529407773687 1.9717892081168e-32 MirTarget -0.188540383634248 0.00595973754453785 NA NA NA hsa-miR-361-5p PLA2G4A 0.0514169367202078 0.382929376393199 -1.85529407773687 1.9717892081168e-32 miRanda -0.504250919786896 0.00245854577917651 NA NA NA hsa-miR-374a-5p PLA2G4A 0.543061152108237 2.19403097299769e-14 -1.85529407773687 1.9717892081168e-32 mirMAP -0.477322231169729 0.000249501916746624 NA NA NA hsa-miR-374b-5p PLA2G4A 0.0804104684417872 0.365593963035077 -1.85529407773687 1.9717892081168e-32 mirMAP -0.293947726971175 0.006867825439803 NA NA NA hsa-miR-590-3p PLA2G4A 1.13702599385212 3.53435739887793e-22 -1.85529407773687 1.9717892081168e-32 miRanda -0.489193495036296 4.85569925069997e-11 NA NA NA hsa-miR-125a-5p PLA2G5 -0.561874059994802 7.3931856356891e-13 2.9004312005942 1.2325420826324e-27 miRanda -1.07156821996216 4.64642714926677e-08 NA NA NA hsa-miR-429 PLA2G5 -2.16569233119434 2.66862243626443e-37 2.9004312005942 1.2325420826324e-27 miRanda -0.668499359545984 7.01186997138673e-17 NA NA NA hsa-miR-324-5p PLA2G6 -0.487750893426456 3.74472736457965e-05 0.682316411790433 7.33596322664269e-06 miRanda -0.282227835071844 6.91880555505667e-05 NA NA NA hsa-miR-125a-5p PLCG1 -0.561874059994802 7.3931856356891e-13 0.609751089662416 1.12377014694825e-19 miRanda -0.13045375090493 0.00755064517220051 NA NA NA hsa-miR-200b-3p PLCG1 -1.70383252137161 2.38979336321755e-30 0.609751089662416 1.12377014694825e-19 TargetScan -0.175885910448865 2.49250011897743e-14 NA NA NA hsa-miR-30a-5p PLCG1 -0.778411951775343 2.73322451127932e-16 0.609751089662416 1.12377014694825e-19 miRNATAP -0.26342973516773 6.65372044643881e-12 NA NA NA hsa-miR-30c-5p PLCG1 -1.08783070774238 2.02505402525786e-24 0.609751089662416 1.12377014694825e-19 miRNATAP -0.22208425619646 2.5275061108132e-11 NA NA NA hsa-miR-362-3p PLCG1 -0.753214251798232 3.0025661608035e-07 0.609751089662416 1.12377014694825e-19 miRanda -0.109722570107135 4.44813555671034e-05 NA NA NA hsa-miR-429 PLCG1 -2.16569233119434 2.66862243626443e-37 0.609751089662416 1.12377014694825e-19 PITA;miRanda;miRNATAP -0.150507552347676 2.69336121445354e-14 NA NA NA hsa-miR-590-3p PLCG2 1.13702599385212 3.53435739887793e-22 -1.65354046944029 1.01289171976521e-32 miRanda -0.459695253589225 2.75512006566686e-12 NA NA NA hsa-miR-30a-5p PPP3CA -0.778411951775343 2.73322451127932e-16 0.0721387123808759 0.234245285293813 miRNAWalker2_validate;miRNATAP -0.118629097747329 0.000383615066757291 NA NA NA hsa-miR-107 PPP3CB 0.140046250553248 0.0943611632552367 -0.487246812937051 5.19737132609125e-20 miRanda -0.100574744257312 0.00721500275471322 NA NA NA hsa-miR-15a-5p PPP3CB 1.42663930007845 1.36006952074963e-57 -0.487246812937051 5.19737132609125e-20 miRNATAP -0.192283738442317 1.15661216413766e-11 NA NA NA hsa-miR-15b-5p PPP3CB 0.773001494057531 1.71784656078957e-16 -0.487246812937051 5.19737132609125e-20 miRNATAP -0.136453760306784 1.39939898640127e-05 NA NA NA hsa-miR-16-5p PPP3CB 0.934012514027655 4.85417898318515e-24 -0.487246812937051 5.19737132609125e-20 miRNATAP -0.134414377057782 1.56084628439769e-05 NA NA NA hsa-miR-330-5p PPP3CB 1.44960468659754 2.12131210588035e-45 -0.487246812937051 5.19737132609125e-20 MirTarget;PITA;miRanda -0.152969334053742 2.9174642891742e-09 NA NA NA hsa-miR-452-5p PPP3CB 2.05325688842141 2.82238393643084e-40 -0.487246812937051 5.19737132609125e-20 MirTarget;miRNATAP -0.117886106917456 6.18756426826884e-12 NA NA NA hsa-miR-590-3p PPP3CB 1.13702599385212 3.53435739887793e-22 -0.487246812937051 5.19737132609125e-20 miRanda -0.12233415261172 5.67792394940471e-07 NA NA NA hsa-miR-500a-3p PPP3CC -1.41379327701944 2.73403824528455e-37 0.254109049885576 7.06908011746755e-08 MirTarget;miRNATAP -0.121534092684039 4.7654464774239e-09 NA NA NA hsa-miR-27b-3p PPP3R1 -0.699527231242518 1.07356023759234e-15 0.157646059727901 0.00380302425401831 miRNATAP -0.147266842249843 7.02192582599604e-06 NA NA NA hsa-miR-30a-5p PPP3R1 -0.778411951775343 2.73322451127932e-16 0.157646059727901 0.00380302425401831 miRNAWalker2_validate;MirTarget;miRNATAP -0.144832345464806 1.24508531197761e-06 NA NA NA hsa-miR-30b-5p PPP3R1 -1.18330589477119 6.8341618466966e-27 0.157646059727901 0.00380302425401831 MirTarget -0.144184046476476 4.67346408532333e-09 NA NA NA hsa-miR-30d-5p PPP3R1 -0.202727675788184 0.00659067084745794 0.157646059727901 0.00380302425401831 MirTarget;miRNATAP -0.210347143440493 1.4459363165293e-07 NA NA NA hsa-miR-142-5p PRKCA 1.88417391525707 1.2096808039882e-27 -1.40949595564765 3.30510040485645e-31 mirMAP -0.203326926537334 1.32429030012509e-07 NA NA NA hsa-miR-146a-5p PRKCA 1.04938133739924 7.51013231709992e-12 -1.40949595564765 3.30510040485645e-31 mirMAP -0.138636449569245 0.00290151925750071 NA NA NA hsa-miR-150-5p PRKCA 1.00371863159681 1.09871676395528e-09 -1.40949595564765 3.30510040485645e-31 mirMAP -0.141463696474327 0.00116284963615584 NA NA NA hsa-miR-17-3p PRKCA 0.723795600017259 5.90151677164931e-18 -1.40949595564765 3.30510040485645e-31 miRNAWalker2_validate -0.55301268177802 1.37146521298911e-11 NA NA NA hsa-miR-181a-5p PRKCA 1.11111114875339 3.97880443756442e-29 -1.40949595564765 3.30510040485645e-31 mirMAP -0.540264161188695 1.18526956498458e-16 NA NA NA hsa-miR-181b-5p PRKCA 1.49054296272357 3.69051660739368e-41 -1.40949595564765 3.30510040485645e-31 mirMAP -0.473733908349652 2.1676855775351e-17 NA NA NA hsa-miR-181c-5p PRKCA 0.762784646696248 4.48373118147729e-10 -1.40949595564765 3.30510040485645e-31 mirMAP -0.256287812602341 1.11910895047438e-05 NA NA NA hsa-miR-186-5p PRKCA 0.507217561043443 9.04455748270995e-10 -1.40949595564765 3.30510040485645e-31 miRNATAP -0.239864584666343 0.00624473839846306 NA NA NA hsa-miR-19b-1-5p PRKCA 0.66692013055553 1.55789130176287e-09 -1.40949595564765 3.30510040485645e-31 mirMAP -0.193605809138291 0.00310670883960429 NA NA NA hsa-miR-224-5p PRKCA 2.84654230414912 3.0480927226395e-47 -1.40949595564765 3.30510040485645e-31 mirMAP -0.224468346181721 5.75169704731423e-13 NA NA NA hsa-miR-2355-3p PRKCA 1.32757890426926 1.88016636795886e-18 -1.40949595564765 3.30510040485645e-31 mirMAP -0.261610517007587 1.83229270594567e-08 NA NA NA hsa-miR-3170 PRKCA 0.664452094631118 2.78926402033808e-05 -1.40949595564765 3.30510040485645e-31 mirMAP -0.143525555001005 0.00205070350789402 NA NA NA hsa-miR-330-3p PRKCA 0.912906550436308 3.35037014057665e-13 -1.40949595564765 3.30510040485645e-31 mirMAP -0.261128612369017 5.50369517469821e-06 NA NA NA hsa-miR-340-5p PRKCA 1.14479851941741 2.91936881701444e-15 -1.40949595564765 3.30510040485645e-31 mirMAP -0.258076358061294 7.18198801898922e-08 NA NA NA hsa-miR-374a-3p PRKCA 1.13863935833993 2.79089304015401e-44 -1.40949595564765 3.30510040485645e-31 mirMAP -0.684628765839887 6.42429291388675e-20 NA NA NA hsa-miR-374a-5p PRKCA 0.543061152108237 2.19403097299769e-14 -1.40949595564765 3.30510040485645e-31 mirMAP -0.522893225273422 1.47637062832505e-07 NA NA NA hsa-miR-452-5p PRKCA 2.05325688842141 2.82238393643084e-40 -1.40949595564765 3.30510040485645e-31 mirMAP -0.33224472833984 1.34300342334138e-16 NA NA NA hsa-miR-590-3p PRKCA 1.13702599385212 3.53435739887793e-22 -1.40949595564765 3.30510040485645e-31 PITA;miRanda;mirMAP;miRNATAP -0.332392461839564 9.25847276505916e-09 NA NA NA hsa-miR-592 PRKCA 2.6404220268798 8.81369998128794e-32 -1.40949595564765 3.30510040485645e-31 miRNATAP -0.172568846986646 3.52884206079864e-09 NA NA NA hsa-miR-200b-3p PRKCB -1.70383252137161 2.38979336321755e-30 0.583904117599654 0.000239395825023428 MirTarget -0.161635318424647 0.00276990701776461 NA NA NA hsa-miR-27b-3p PRKCB -0.699527231242518 1.07356023759234e-15 0.583904117599654 0.000239395825023428 MirTarget;miRNATAP -0.381848642069096 8.29210459175488e-05 NA NA NA hsa-miR-30a-3p PRKCB -0.955360819934585 1.97009535429185e-20 0.583904117599654 0.000239395825023428 mirMAP -0.27445649163855 0.000675651397734009 NA NA NA hsa-miR-30b-5p PRKCB -1.18330589477119 6.8341618466966e-27 0.583904117599654 0.000239395825023428 mirMAP -0.43302228945984 2.35087485736611e-09 NA NA NA hsa-miR-30c-5p PRKCB -1.08783070774238 2.02505402525786e-24 0.583904117599654 0.000239395825023428 mirMAP -0.200266218821399 0.00954411836448046 NA NA NA hsa-miR-30d-3p PRKCB -0.249777194282131 0.00235356711813496 0.583904117599654 0.000239395825023428 mirMAP -0.527711285390385 8.06872957758744e-07 NA NA NA hsa-miR-30d-5p PRKCB -0.202727675788184 0.00659067084745794 0.583904117599654 0.000239395825023428 mirMAP -0.615678537820375 1.81242737170691e-07 NA NA NA hsa-miR-361-5p PRKCB 0.0514169367202078 0.382929376393199 0.583904117599654 0.000239395825023428 MirTarget;miRanda;miRNATAP -0.499291115851109 0.00117224790143438 NA NA NA hsa-miR-429 PRKCB -2.16569233119434 2.66862243626443e-37 0.583904117599654 0.000239395825023428 MirTarget;miRanda;miRNATAP -0.192274100704377 2.89126645159923e-05 NA NA NA hsa-miR-101-3p PTGS2 0.683973909682285 2.88573524246948e-15 -1.79650281819741 7.34268106167523e-15 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.957325116627311 3.19311680511711e-11 26530100;21430074;24759835;26556718;24289600;23644120;24958470;26617722;19133256;24528073;25109742;23013439 Luciferase assay revealed that COX-2 was a direct target for miR-101-3p and overexpression of miR-101-3p decreased cellular COX-2 protein expression; Finally downregulation of miR-101-3p expression and upregulation of COX-2 was found in ESCC specimens from patients with smoking history; Taken together our findings revealed a new post-transcriptional mechanism by which CSE regulated COX-2 expression to favor cancer cell proliferation suggesting miR-101-3p as a potential biomarker and therapeutic target for smoke-related ESCC;Enforced expression of miR 101 inhibits prostate cancer cell growth by modulating the COX 2 pathway in vivo; In this study we investigated the mechanism of microRNA-101 miR-101-regulated COX-2 expression and the therapeutic potential of exogenous miR-101 for COX-2-associated cancer; We found that miR-101 inhibited COX-2 posttranscriptional expression by directly binding to the 3'-untranslated region 3'-UTR of COX-2 mRNA; In conclusion COX-2 is a direct target in miR-101 regulation of posttranscription; These data suggest that exogenous miR-101 may provide a new cancer therapy by directly inhibiting COX-2 expression;MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels;Cyclooxygenase 2 a Potential Therapeutic Target Is Regulated by miR 101 in Esophageal Squamous Cell Carcinoma; This study investigated the effect of miR-101 on ESCC through modulating COX-2 expression in ESCC; The luciferase reporter assay was used to verify COX-2 as a direct target of miR-101; Furthermore COX-2 was shown to be a target of miR-101;The expression of COX-2 in Hela cell was also examined by immunohistochemical staining and the correlation with miR-101 expression was analysed; Thus reduced miR-101 expression could participate in the development of cervical cancer at least partly through loss of inhibition of target gene COX-2 which probably occurs in a relative late phase of carcinogenesis;Expressions of COX 2 PKC α and miR 101 in gastric cancer and their correlations; To investigate the expressions of miR-101 protein kinase C-α PKC-α and cyclooxygenase-2 COX-2 in gastric cancer GC tissue and their correlations; RT-qPCR was used to examine miR-101 expression and Western blotting employed to detect PKC-α and COX-2 expressions in 57 cases of gastric cancer tissues and paired normal gastric mucosal tissues; The gastric cancer tissues showed a significantly lower miR-101 expression Z=6.102 P<0.05 but significantly higher expressions of COX-2 Z=14.436 P<0.05 and PKC-α Z=6.955 P<0.05 than the normal gastric tissues; PKC-α expression was positively correlated r=0.531 P<0.05 and miR-101 expression negatively correlated r=-0.627 P<0.05 with COX-2 expression in gastric cancer tissues; miR-101 PKC-α and COX-2 all play a role in the tumorigenesis and progression of gastric cancer; miR-101 and PKC-α might be new potential therapeutic targets for inhibiting COX-2 in gastric cancer;Interestingly cyclooxygenase-2 inhibition by aspirin or celecoxib abrogated IL-1β-mediated repression of miR-101 and IL-1β-mediated activation of Lin28B along with their stimulatory effects on NSCLC cell proliferation and migration;Immunohistochemistry was performed to assess protein expression of the miR-101 target gene COX-2; Overexpression of miR-101 decreased expression of its target gene Cox-2 and inhibited proliferation and invasion and promoted apoptosis to suppress tumorigenicity;MiR 101 downregulation is involved in cyclooxygenase 2 overexpression in human colon cancer cells; In this paper we report the inverse correlation between COX-2 and miR-101 expression in colon cancer cell lines and we demonstrated in vitro the direct inhibition of COX-2 mRNA translation mediated by miR-101; These findings provide a novel molecular insight in the modulation of COX-2 at post-transcriptional level by miR-101 and strengthen the observation that miRNAs are highly implicated in the control of gene expression; An impairment of miR-101 levels could represent one of the leading causes of COX-2 overexpression in colon cancer cells;Roles of MiR 101 and its target gene Cox 2 in early diagnosis of cervical cancer in Uygur women; Use of down-regulation of miR-101 and up-regulation of Cox-2 as markers may play a role in early diagnosis of cervical cancer in Uygur women;Enforced expression of miR 101 enhances cisplatin sensitivity in human bladder cancer cells by modulating the cyclooxygenase 2 pathway;Downregulation of miR 101 in gastric cancer correlates with cyclooxygenase 2 overexpression and tumor growth; Here we characterize miR-101 expression and its role in the regulation of COX-2 expression which in turn will provide us with additional insights into the potential therapeutic benefits of exogenous miR-101 for treatment of gastric cancer; We also found an inverse correlation between miR-101 and COX-2 expression in both gastric cancer specimens and cell lines; One possible mechanism of interaction is that miR-101 inhibited COX-2 expression by directly binding to the 3'-UTR of COX-2 mRNA; These results collectively indicate that miR-101 may function as a tumor suppressor in gastric cancer with COX-2 as a direct target ;;;;tumorigenesis;progression;tumorigenesis;;;;;; esophageal cancer;prostate cancer;liver cancer;esophageal cancer;cervical and endocervical cancer;gastric cancer;lung cancer;cervical and endocervical cancer;colon cancer;cervical and endocervical cancer;bladder cancer;gastric cancer hsa-miR-126-5p PTGS2 0.785607261431085 5.77058629454465e-13 -1.79650281819741 7.34268106167523e-15 MirTarget -0.319967495326128 0.00681190240203582 NA NA NA hsa-miR-128-3p PTGS2 0.475045893035043 2.6255647468e-06 -1.79650281819741 7.34268106167523e-15 miRNAWalker2_validate -0.710128261370724 3.0998993991119e-08 NA NA NA hsa-miR-16-5p PTGS2 0.934012514027655 4.85417898318515e-24 -1.79650281819741 7.34268106167523e-15 miRNAWalker2_validate;miRTarBase -0.541478807002747 5.26751233626035e-05 24759835;25196524 MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels;Artesunate induces apoptosis of bladder cancer cells by miR 16 regulation of COX 2 expression; Cyclooxygenase-2 COX-2 and miR-16 expression levels were determined with real-time PCR; ART efficiently inhibited orthotopic tumor growth in the bladder cancer rat which is accompanied with an increase of miR-16 expression and a decrease of COX-2 expression; ART significantly increased miR-16 expression and decreased the expression of COX-2 and the production of PGE2; More importantly down-regulation of miR-16 expression could reverse the effect of ART on apoptosis and COX-2 expression in bladder cells; In conclusion ART can elicit an anti-tumor effect against bladder cancer by up-regulation of miR-16 expression which resulted in the decrease of COX-2 expression and PGE2 production ; liver cancer;bladder cancer hsa-miR-181a-5p PTGS2 1.11111114875339 3.97880443756442e-29 -1.79650281819741 7.34268106167523e-15 miRNAWalker2_validate -0.692888180319684 1.00024706927524e-08 NA NA NA hsa-miR-28-5p PTGS2 0.461962042257226 3.32424690573327e-11 -1.79650281819741 7.34268106167523e-15 MirTarget;miRanda -1.16634755299529 2.14182637867728e-10 NA NA NA hsa-miR-338-5p PTGS2 0.628429807914222 1.27575140717947e-06 -1.79650281819741 7.34268106167523e-15 mirMAP -0.559440515555329 3.43803127495256e-08 NA NA NA hsa-miR-374a-5p PTGS2 0.543061152108237 2.19403097299769e-14 -1.79650281819741 7.34268106167523e-15 mirMAP -0.628926435080016 0.00053847371846309 NA NA NA hsa-miR-374b-5p PTGS2 0.0804104684417872 0.365593963035077 -1.79650281819741 7.34268106167523e-15 mirMAP -0.452958821151266 0.00275149263586928 NA NA NA hsa-miR-542-3p PTGS2 0.431147917094433 0.000254981247606435 -1.79650281819741 7.34268106167523e-15 miRanda -0.409646759516388 0.000253009163396837 NA NA NA hsa-miR-576-5p PTGS2 1.06681109513983 5.69294424466526e-24 -1.79650281819741 7.34268106167523e-15 mirMAP -0.355638212327836 0.0024636380921386 NA NA NA hsa-miR-342-3p RAC3 1.4124432570595 1.07208971556131e-28 -1.40504132869683 4.24492750834751e-13 miRanda -0.303985376974766 0.000136219209735901 NA NA NA hsa-miR-146b-3p RAF1 1.20941495066078 2.12939149602665e-10 -0.729326295365523 1.03493473489106e-42 MirTarget;PITA;miRNATAP -0.126960331865385 9.60010767311038e-15 NA NA NA hsa-miR-15a-5p RAF1 1.42663930007845 1.36006952074963e-57 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.324293625748972 2.12345656575569e-29 NA NA NA hsa-miR-15b-5p RAF1 0.773001494057531 1.71784656078957e-16 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.217283143578276 6.68293363881507e-11 NA NA NA hsa-miR-16-5p RAF1 0.934012514027655 4.85417898318515e-24 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.2832583907681 1.12454604973701e-18 26527888 Besides we identify that Raf1 is a direct target of miR-15a/b miR-16 and miR-195 by dual luciferase reporter assay thyroid cancer hsa-miR-186-5p RAF1 0.507217561043443 9.04455748270995e-10 -0.729326295365523 1.03493473489106e-42 miRNAWalker2_validate -0.248932939680122 1.31766215047697e-10 NA NA NA hsa-miR-195-5p RAF1 0.346502644882604 0.0092562828415903 -0.729326295365523 1.03493473489106e-42 miRTarBase;MirTarget;miRNATAP -0.106749755319653 1.79108008549216e-05 26527888;21350001;27153315;23760062 miR 195 is a key regulator of Raf1 in thyroid cancer; Besides we identify that Raf1 is a direct target of miR-15a/b miR-16 and miR-195 by dual luciferase reporter assay; Furthermore exogenous overexpression of miR-195 significantly inhibits the protein expression of Raf1 and blocks the thyroid cancer cell proliferation;Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering with RAF 1 degradation by miR 195; Molecular function analyses revealed that IGF2BP2 regulates RAF1 expression through blocking its degradation by miR-195;Upregulation of miR 195 increases the sensitivity of breast cancer cells to Adriamycin treatment through inhibition of Raf 1; The data showed that miR-195 expression was low in breast cancer cells and multidrug-resistant breast cancer tissues which was associated with reduced Raf-1 expression in vitro and ex vivo; Induction of miR-195 expression promoted tumor cell apoptosis and inhibited breast cancer cell viability but induced the sensitivity of breast cancer cells to Adriamycin treatment and was associated with inhibition of Raf-1 expression in breast cancer cells; Moreover knockdown of Raf-1 expression had similar effects of miR-195 mimics on breast cancer cells both of which were able to suppress Bcl-2 and P-glycoprotein expression in breast cancer cells; The data from the current study demonstrated that expression of miR-195 was inversely associated with Raf-1 expression in breast cancer cell lines and tissue specimens and that Raf-1 is the target gene of miR-195 ;;poor survival; thyroid cancer;breast cancer;colorectal cancer;breast cancer hsa-miR-19a-3p RAF1 0.722913586880779 2.76301458932381e-10 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.154284306170029 3.61502307447547e-08 NA NA NA hsa-miR-19b-3p RAF1 0.195940928879427 0.0300512922542325 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.115125075816159 0.00199179078014951 NA NA NA hsa-miR-331-3p RAF1 0.431607034018882 6.83022920590941e-05 -0.729326295365523 1.03493473489106e-42 MirTarget;miRNATAP -0.158262304030351 1.65741452145876e-07 NA NA NA hsa-miR-484 RAF1 0.571987778099603 9.67278224458421e-10 -0.729326295365523 1.03493473489106e-42 MirTarget -0.240322437451901 1.50205113397331e-12 NA NA NA hsa-miR-497-5p RAF1 0.227757383708836 0.0600073987853074 -0.729326295365523 1.03493473489106e-42 miRTarBase;MirTarget;miRNATAP -0.119677885863477 1.30076085946277e-05 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-590-3p RAF1 1.13702599385212 3.53435739887793e-22 -0.729326295365523 1.03493473489106e-42 miRanda -0.179633605652733 4.3114164233555e-12 NA NA NA hsa-miR-93-3p RAF1 0.379664250785728 9.76327751780657e-05 -0.729326295365523 1.03493473489106e-42 miRNATAP -0.192339109650426 1.01632622523622e-08 NA NA NA hsa-miR-942-5p RAF1 0.978672610596303 3.12802933163696e-12 -0.729326295365523 1.03493473489106e-42 MirTarget -0.130737374750736 7.69722175616835e-09 NA NA NA hsa-miR-15b-5p SPHK2 0.773001494057531 1.71784656078957e-16 -1.0340227728694 1.18010160042517e-26 mirMAP -0.260825817603053 8.774921865569e-06 NA NA NA hsa-miR-16-5p SPHK2 0.934012514027655 4.85417898318515e-24 -1.0340227728694 1.18010160042517e-26 mirMAP -0.295854388214277 3.11485764096968e-07 NA NA NA hsa-miR-338-3p SPHK2 0.906250377628867 2.76970900371139e-15 -1.0340227728694 1.18010160042517e-26 miRanda;miRNATAP -0.229364230592114 1.68263403693239e-06 NA NA NA hsa-miR-361-3p SPHK2 1.08992546227594 1.13197240706704e-36 -1.0340227728694 1.18010160042517e-26 mirMAP -0.356292359903462 1.61857736830898e-09 NA NA NA hsa-miR-484 SPHK2 0.571987778099603 9.67278224458421e-10 -1.0340227728694 1.18010160042517e-26 miRNATAP -0.243499582627859 5.50980544623182e-05 NA NA NA hsa-miR-590-3p SPHK2 1.13702599385212 3.53435739887793e-22 -1.0340227728694 1.18010160042517e-26 miRanda -0.236359233259057 2.25060438420227e-07 NA NA NA hsa-miR-10b-3p SRC -0.8205021989966 7.84331443044781e-21 0.0854633248817942 0.255962595627229 MirTarget -0.255505133475381 5.12152940038878e-09 NA NA NA hsa-miR-181a-2-3p SRC 0.549613348249471 1.48987286432989e-10 0.0854633248817942 0.255962595627229 mirMAP -0.139537883411153 0.0031141574296147 NA NA NA hsa-miR-1-3p VEGFA -1.38047704190737 9.11649491260066e-13 3.1902151031465 4.32161998112301e-60 MirTarget -0.377004508862683 2.92409820832604e-09 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-106a-5p VEGFA -0.830908656792615 2.67547872901508e-10 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase -0.565883993248695 1.96742640916183e-09 NA NA NA hsa-miR-125a-5p VEGFA -0.561874059994802 7.3931856356891e-13 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRanda -0.691987422405189 1.65186087473265e-05 22768249 Ectopic expression of MiR 125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF; Furthermore miR-125a expression was inversely correlated with both MMP11 and VEGF-A expression in HCC tissues; MiR-125a inhibits the proliferation and metastasis of HCC by targeting MMP11 and VEGF-A metastasis liver cancer hsa-miR-133a-3p VEGFA -1.27121745308165 9.16266399887975e-11 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.334559517340425 1.60041057990039e-07 NA NA NA hsa-miR-134-5p VEGFA -0.940639322366899 1.24417590236773e-06 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.273283677460691 3.09936265314409e-05 NA NA NA hsa-miR-199a-5p VEGFA -1.64658415208633 1.01615659358973e-23 3.1902151031465 4.32161998112301e-60 miRanda;miRNATAP -0.582562369754787 1.33420730972332e-16 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA -2.39483476763681 1.04659509514884e-17 3.1902151031465 4.32161998112301e-60 miRanda -0.388055722385546 8.86533920644866e-20 NA NA NA hsa-miR-200b-3p VEGFA -1.70383252137161 2.38979336321755e-30 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.652162092625576 6.74456951743668e-18 20420713;22904162;25301739 We also found strong anti-correlation between VEGFA and the miR-200 family of microRNA: miR-200a* 200b 200c and miR-141;In contrast a positive correlation was observed between VEGF-A and miR-200b and -210;CCL5 promotes VEGF dependent angiogenesis by down regulating miR 200b through PI3K/Akt signaling pathway in human chondrosarcoma cells; We also demonstrated CCL5 inhibiting miR-200b expression and miR-200b mimic reversing the CCL5-enhanced VEGF expression and angiogenesis ;; kidney renal cell cancer;endometrial cancer;sarcoma hsa-miR-200c-3p VEGFA -5.40303134829523 2.74173143360645e-94 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.482839305599163 5.43978252023974e-53 24205206;25445393 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway;Analysis revealed a negative correlation between miR-200c and VEGFA expressions r=-468 ; lung squamous cell cancer;breast cancer hsa-miR-20b-5p VEGFA -1.30218163823367 6.87172815978149e-17 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase -0.658858628437659 2.63194222583861e-18 22901144;20232316;26612965 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha;We investigated whether and how miR-20b can regulate the expression of vascular endothelial growth factor VEGF in MCF-7 breast cancer cells under normoxic and hypoxia-mimicking conditions CoCl2 exposure; Using immunoblotting ELISA and quantitative real-time PCR we demonstrated that miR-20b decreased VEGF protein levels at 4 and 24 h following CoCl2 treatment and VEGF mRNA at 4 h of treatment; In addition miR-20b reduced VEGF protein expression in untreated cells;Clinicopathological Significance of MicroRNA 20b Expression in Hepatocellular Carcinoma and Regulation of HIF 1α and VEGF Effect on Cell Biological Behaviour; Meanwhile the HIF-1α and VEGF targets of miR-20b have been confirmed; We found not only miR-20b regulation of HIF-1α and VEGF in normal but also regulation of miR-20b in hypoxia; The whole study suggests that miR-20b HIF-1α and VEGF serve as a potential therapeutic agent for hepatocellular carcinoma ;; breast cancer;breast cancer;liver cancer hsa-miR-29a-3p VEGFA -0.431613225927952 4.10166815070288e-08 3.1902151031465 4.32161998112301e-60 MirTarget -1.19030784245849 4.8715212353082e-14 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29b-2-5p VEGFA -0.297854154636098 0.00260919277325581 3.1902151031465 4.32161998112301e-60 MirTarget -0.376634138151447 0.00423612473269059 NA NA NA hsa-miR-29b-3p VEGFA -0.228125979913806 0.0271621721891603 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.569482283980511 5.47301472525388e-06 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-335-5p VEGFA -2.09515619961552 1.03765771499548e-25 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.560731405851007 4.75077750352693e-23 NA NA NA hsa-miR-362-3p VEGFA -0.753214251798232 3.0025661608035e-07 3.1902151031465 4.32161998112301e-60 miRanda -0.478977237100648 5.87028343678109e-08 NA NA NA hsa-miR-429 VEGFA -2.16569233119434 2.66862243626443e-37 3.1902151031465 4.32161998112301e-60 MirTarget;miRanda;miRNATAP -0.567681641585143 1.7112668371199e-18 NA NA NA hsa-miR-9-5p VEGFA -2.23538606210968 1.28143998950751e-12 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.222102357667036 1.24335781156383e-08 NA NA NA