miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-141-3p ABL1 0.730011517758706 0.000120338355004032 0.0849974459663763 0.36039518968777 MirTarget -0.195685516424929 5.69172755372042e-22 NA NA NA hsa-miR-149-5p ABL1 0.443278770827687 0.0642022866136881 0.0849974459663763 0.36039518968777 miRNAWalker2_validate -0.119524446807528 3.96367502239966e-13 NA NA NA hsa-miR-19a-3p ABL1 1.35800152353624 2.80940447111944e-12 0.0849974459663763 0.36039518968777 mirMAP -0.165948125062023 3.91300650024682e-17 NA NA NA hsa-miR-200a-3p ABL1 0.607140814457753 0.00289840524858752 0.0849974459663763 0.36039518968777 MirTarget -0.167516745460652 1.77198024575116e-18 NA NA NA hsa-miR-203a-3p ABL1 0.0441399794719697 0.880456392176704 0.0849974459663763 0.36039518968777 miRTarBase -0.112778482819384 2.7156053901475e-17 21454413 Treatment of lymphoma B cells with demethylating agents led to increased miR-203 expression and the concomitant downregulation of ABL1 confirming the epigenetic regulation of this miRNA; In summary our results show that the transformation from gastritis to MALT lymphoma is epigenetically regulated by miR-203 promoter methylation and identify ABL1 as a novel target for the treatment of this malignancy lymphoma hsa-miR-29a-5p ABL1 0.323252792625584 0.0370417231222825 0.0849974459663763 0.36039518968777 MirTarget -0.102953622277546 7.34902427999851e-05 NA NA NA hsa-miR-29b-3p ABL1 -0.110721443686039 0.511264554091106 0.0849974459663763 0.36039518968777 miRNATAP -0.146475892102919 5.88550435188412e-10 NA NA NA hsa-miR-30b-5p ABL1 -0.400238605368173 0.00346540992719245 0.0849974459663763 0.36039518968777 MirTarget;miRNATAP -0.172952437426206 2.83461995910967e-09 NA NA NA hsa-miR-30c-5p ABL1 0.021222006155897 0.886366656528128 0.0849974459663763 0.36039518968777 MirTarget;miRNATAP -0.18970460046346 1.27944212904127e-12 NA NA NA hsa-miR-193a-3p ANAPC1 0.22120710726779 0.111827069464729 0.110100654433068 0.293883308357679 miRanda -0.123804513142277 0.000158850060827304 NA NA NA hsa-miR-26b-5p ANAPC1 -0.254478038884324 0.0285227763044636 0.110100654433068 0.293883308357679 miRNAWalker2_validate -0.187783262711385 1.61909837890634e-06 NA NA NA hsa-miR-100-5p ANAPC11 -1.85857794619369 1.248973638996e-25 0.226220967268143 0.0398543254184585 miRNAWalker2_validate -0.104351325194282 4.50192913757553e-05 NA NA NA hsa-miR-542-3p ANAPC7 0.643308814904977 8.81635403230104e-07 -0.0807710637854484 0.219527633938703 miRanda -0.101098737598471 2.53336139379471e-06 NA NA NA hsa-miR-18a-5p ATM 1.65455873230328 3.76457892277775e-20 -0.093354974252863 0.454138180986134 miRNAWalker2_validate;miRTarBase;MirTarget -0.172854853213816 1.55248713992951e-09 23437304;25963391;23857602;23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression colorectal cancer;cervical and endocervical cancer;breast cancer;colon cancer hsa-miR-19b-3p ATM 0.538732279378089 0.000622008277870679 -0.093354974252863 0.454138180986134 miRNAWalker2_validate -0.186784239327415 3.93187101386662e-08 NA NA NA hsa-miR-203a-3p ATM 0.0441399794719697 0.880456392176704 -0.093354974252863 0.454138180986134 MirTarget -0.104881351322909 9.03651632141775e-09 24145123;27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression drug resistance;metastasis colorectal cancer;gastric cancer hsa-miR-21-5p ATM 1.62465922021121 3.44191300985109e-58 -0.093354974252863 0.454138180986134 mirMAP -0.140220573701406 0.00355116923594901 26289851 MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy thyroid cancer hsa-miR-30c-5p ATM 0.021222006155897 0.886366656528128 -0.093354974252863 0.454138180986134 mirMAP -0.12262645993067 0.000806314047643549 NA NA NA hsa-miR-339-5p ATM 1.07771430326938 2.45772601859307e-09 -0.093354974252863 0.454138180986134 miRanda -0.139243170775692 2.1104639922551e-06 NA NA NA hsa-miR-455-5p ATM 1.408595672323 5.52039116456697e-22 -0.093354974252863 0.454138180986134 miRanda -0.217802614613522 5.72421455047167e-10 NA NA NA hsa-miR-500a-5p ATM 0.675401699376111 8.24389004707854e-05 -0.093354974252863 0.454138180986134 mirMAP -0.142109646438286 5.47687546110341e-06 NA NA NA hsa-miR-576-5p ATM 0.940432050128373 6.90227595663302e-12 -0.093354974252863 0.454138180986134 mirMAP -0.165312006285652 1.91611455442744e-05 NA NA NA hsa-miR-590-5p ATM 0.763025362395968 3.65305892505623e-09 -0.093354974252863 0.454138180986134 mirMAP -0.147037048698993 0.000379931177124788 NA NA NA hsa-miR-30b-5p ATR -0.400238605368173 0.00346540992719245 0.338492924444351 0.000892078828786625 mirMAP -0.107889073862237 0.000888694985860714 NA NA NA hsa-miR-139-5p BUB1 -1.46099200329485 7.85040381494472e-22 1.79401606733955 3.40093824308439e-38 miRanda -0.28867794910836 8.65970366136342e-13 NA NA NA hsa-miR-199a-5p BUB1 -0.364835768178638 0.0435119211101981 1.79401606733955 3.40093824308439e-38 miRanda -0.191892964912779 7.99367483200517e-08 NA NA NA hsa-miR-199b-5p BUB1 -1.08432682485992 7.68241801134089e-10 1.79401606733955 3.40093824308439e-38 miRanda -0.227928219031319 2.12371211849233e-10 NA NA NA hsa-miR-495-3p BUB1 -1.47803501311999 6.88839745293927e-13 1.79401606733955 3.40093824308439e-38 MirTarget -0.203184632032314 2.86042778161751e-11 NA NA NA hsa-miR-653-5p BUB1 -1.04995590592975 8.04165192833917e-08 1.79401606733955 3.40093824308439e-38 MirTarget -0.19590091174433 2.194521222695e-09 NA NA NA hsa-miR-22-3p BUB1B 0.00776313533473072 0.926356548861307 1.71486697303925 1.95081377971148e-31 miRNAWalker2_validate -0.276017172188679 0.000804393800109216 NA NA NA hsa-miR-486-5p BUB1B -1.70341092285685 6.64232609099498e-14 1.71486697303925 1.95081377971148e-31 miRanda -0.111954015802004 0.000120707492505391 NA NA NA hsa-miR-107 CCNA1 -0.0447040564279497 0.671618791096755 1.54036441608558 0.00197491909859988 miRanda -0.677826760987871 0.00113449650460838 NA NA NA hsa-miR-30a-5p CCNA1 -1.79779915425811 1.93360169837799e-26 1.54036441608558 0.00197491909859988 MirTarget -0.476840275421781 9.41877573955024e-05 NA NA NA hsa-miR-30b-5p CCNA1 -0.400238605368173 0.00346540992719245 1.54036441608558 0.00197491909859988 MirTarget -0.50075151653539 0.00164006568546272 NA NA NA hsa-miR-30c-5p CCNA1 0.021222006155897 0.886366656528128 1.54036441608558 0.00197491909859988 MirTarget -0.444600256735735 0.00251300843195929 NA NA NA hsa-miR-30d-5p CCNA1 -0.38399848121878 0.000171129616944749 1.54036441608558 0.00197491909859988 MirTarget -1.14858558540343 5.80914673139817e-08 NA NA NA hsa-miR-30e-5p CCNA1 -1.02114836019762 6.81961221797866e-17 1.54036441608558 0.00197491909859988 MirTarget -1.32315014377152 5.07171929525068e-15 NA NA NA hsa-miR-320b CCNA1 1.23473838180754 3.04337566045537e-14 1.54036441608558 0.00197491909859988 miRanda -0.446132735071568 0.000630264358290649 NA NA NA hsa-miR-199a-5p CCNA2 -0.364835768178638 0.0435119211101981 1.57175220032307 1.1085221982606e-28 miRanda -0.209426529667421 4.0939114925222e-09 NA NA NA hsa-miR-199b-5p CCNA2 -1.08432682485992 7.68241801134089e-10 1.57175220032307 1.1085221982606e-28 miRanda -0.233585542901346 6.84931275782712e-11 NA NA NA hsa-miR-218-5p CCNA2 -1.0725338636959 3.61493686604269e-09 1.57175220032307 1.1085221982606e-28 MirTarget -0.140855598999061 6.31303859388332e-05 NA NA NA hsa-miR-299-5p CCNA2 -1.92445654064493 1.52402531359074e-16 1.57175220032307 1.1085221982606e-28 miRNATAP -0.23789231017066 1.30477134388016e-19 NA NA NA hsa-miR-29a-3p CCNA2 -1.26881270980079 2.82496991513463e-22 1.57175220032307 1.1085221982606e-28 MirTarget -0.123711866254684 0.00993687306670456 NA NA NA hsa-miR-29c-3p CCNA2 -2.08166260448948 8.3238369390898e-24 1.57175220032307 1.1085221982606e-28 MirTarget -0.115144372366957 0.000122254936795811 NA NA NA hsa-miR-139-5p CCNB1 -1.46099200329485 7.85040381494472e-22 1.44538211790055 1.41324264488903e-25 miRanda -0.202873863849802 3.05511373822587e-07 NA NA NA hsa-let-7a-5p CCNB2 -0.439381775414001 3.1119785480023e-05 1.82527116734947 3.50769542184975e-39 miRNAWalker2_validate -0.171130721484154 0.00603586755919132 NA NA NA hsa-let-7c-5p CCNB2 -2.07953368242668 3.46048888391218e-23 1.82527116734947 3.50769542184975e-39 miRNAWalker2_validate -0.203186123688501 4.53821488190806e-12 NA NA NA hsa-let-7g-5p CCND1 -0.250780249469264 0.00939610188330072 -0.0109881197784345 0.959465409721582 miRNATAP -0.424829740163156 1.3974509451707e-05 NA NA NA hsa-miR-106a-5p CCND1 0.67978010057847 0.00221925869726092 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.290355514799433 2.22440819238953e-12 NA NA NA hsa-miR-1266-5p CCND1 -0.595481713934774 0.0201336437562675 -0.0109881197784345 0.959465409721582 MirTarget -0.139245086566564 0.000186104290921039 NA NA NA hsa-miR-142-3p CCND1 1.12754191614028 1.68798138028946e-08 -0.0109881197784345 0.959465409721582 miRanda -0.212388247517233 4.15485864028608e-06 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-142-5p CCND1 0.288897753038094 0.0900009317815725 -0.0109881197784345 0.959465409721582 PITA -0.191106128320911 0.000532572974747186 NA NA NA hsa-miR-150-5p CCND1 -0.243749814009231 0.331546276920338 -0.0109881197784345 0.959465409721582 mirMAP -0.180131286994855 1.27780213542857e-06 NA NA NA hsa-miR-155-5p CCND1 0.533437622040649 0.00248671179205372 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.205881873012998 0.000104382699617692 26955820 MicroRNA 155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1 staging gastric cancer hsa-miR-15a-5p CCND1 0.783550182002274 2.60699595655907e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.320464086146859 4.59241835770022e-05 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 0.85315666454713 3.79816274836297e-12 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.196519284459032 0.00913339894150689 NA NA NA hsa-miR-16-1-3p CCND1 0.955017760172879 5.95379292601146e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase -0.299307340787817 2.12501301813106e-06 22922827;18483394 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ; sarcoma;lymphoma hsa-miR-16-5p CCND1 0.521122945828175 1.40561786410572e-06 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.36160545188711 2.92815156758109e-05 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-19a-3p CCND1 1.35800152353624 2.80940447111944e-12 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;miRNATAP -0.12556465980021 0.0080645437414565 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 0.757034032029085 2.99828133413343e-07 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase -0.202417906859997 0.00132907107963613 NA NA NA hsa-miR-19b-3p CCND1 0.538732279378089 0.000622008277870679 -0.0109881197784345 0.959465409721582 miRNATAP -0.231848363677157 9.5371115518645e-05 NA NA NA hsa-miR-20a-5p CCND1 1.1531986665452 1.02385132917958e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.150528956777027 0.00569825749150082 NA NA NA hsa-miR-20b-5p CCND1 0.345967670847176 0.232014828043601 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.250103392191291 2.8858693936891e-15 NA NA NA hsa-miR-29b-3p CCND1 -0.110721443686039 0.511264554091106 -0.0109881197784345 0.959465409721582 mirMAP -0.182509877041615 0.00109069300418897 NA NA NA hsa-miR-29c-3p CCND1 -2.08166260448948 8.3238369390898e-24 -0.0109881197784345 0.959465409721582 mirMAP -0.163903476961256 0.000152217345834049 NA NA NA hsa-miR-33a-3p CCND1 0.20371038027126 0.212335697664505 -0.0109881197784345 0.959465409721582 MirTarget -0.204409670414224 0.000471939794699908 NA NA NA hsa-miR-34a-5p CCND1 -0.117372471043915 0.364001947180738 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309736660444851 2.09961171943065e-05 25792709;21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a ; liver cancer;breast cancer hsa-miR-425-5p CCND1 0.931027421598738 6.46235724408844e-08 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.149225802492201 0.00573052989307961 NA NA NA hsa-miR-497-5p CCND1 -0.966244470847844 5.26505649147857e-12 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.266892367444044 4.86480308910068e-05 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-590-3p CCND1 0.221436901462551 0.0965904764063157 -0.0109881197784345 0.959465409721582 mirMAP -0.238086291527056 0.000767975801470639 NA NA NA hsa-miR-7-1-3p CCND1 1.13646121619622 1.49823237535933e-14 -0.0109881197784345 0.959465409721582 mirMAP -0.221180507811752 0.000359772635429063 NA NA NA hsa-miR-9-5p CCND1 1.65694862043766 2.08325802567323e-05 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.135043708232949 1.13694784335034e-08 NA NA NA hsa-miR-92a-3p CCND1 0.994679542307232 1.32587679156217e-16 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.235491439560111 0.00199944237198536 NA NA NA hsa-miR-942-5p CCND1 0.678652135586536 2.58063518495056e-07 -0.0109881197784345 0.959465409721582 MirTarget -0.230928848103094 0.0011113987419772 NA NA NA hsa-miR-224-3p CCND2 0.502645536188015 0.0081142387260641 0.148711904010299 0.532420631377314 mirMAP -0.312870902501466 8.12446049333883e-09 NA NA NA hsa-miR-27b-3p CCND3 -0.732682718863563 2.26896143573324e-09 -0.048043868607146 0.631560985924681 miRNAWalker2_validate -0.132150579088403 0.000160876577060277 NA NA NA hsa-miR-125b-5p CCNE1 -0.993460109818276 5.07736727659894e-12 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate -0.277374392819013 5.31956215938705e-11 NA NA NA hsa-miR-151a-3p CCNE1 0.131002217498676 0.295273522160941 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate -0.150265962772684 0.00298585050443392 NA NA NA hsa-miR-195-5p CCNE1 -1.8367376818177 6.9944883988895e-31 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate;MirTarget;miRNATAP -0.309888398159948 1.15906313064363e-17 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-215-5p CCNE1 -0.757663683237828 5.72998183244808e-05 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate -0.129994430039298 9.70603819621136e-05 NA NA NA hsa-miR-26a-5p CCNE1 -1.09269574587169 1.24020612216319e-22 1.47144541933057 8.39227402888879e-27 miRNAWalker2_validate;miRTarBase;miRNATAP -0.491075252836977 6.85651906736478e-21 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-497-5p CCNE1 -0.966244470847844 5.26505649147857e-12 1.47144541933057 8.39227402888879e-27 MirTarget;miRNATAP -0.164722219234429 0.000184434596017171 24112607;25909221;24909281 Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells;miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1 ;; breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-30a-5p CCNE2 -1.79779915425811 1.93360169837799e-26 1.23951713462192 5.15429419774609e-15 miRNATAP -0.160843483864371 5.22163952330061e-05 NA NA NA hsa-miR-369-3p CCNE2 -1.2344419076994 2.66882944171146e-10 1.23951713462192 5.15429419774609e-15 PITA -0.244374203286038 3.35442431580483e-12 NA NA NA hsa-miR-23a-3p CCNH 0.348231698801568 6.4911858506572e-05 -0.254655348745367 0.000553048211854801 MirTarget -0.144674193619874 9.17090809722211e-05 NA NA NA hsa-let-7a-3p CDC14A 0.0966652362351867 0.423761916840503 -0.494402478155925 0.00361931081486212 mirMAP -0.231141238603856 0.000177228013530195 NA NA NA hsa-miR-324-5p CDC14A 1.66709479707179 1.45961450445769e-23 -0.494402478155925 0.00361931081486212 miRanda -0.154367339672718 0.000281066422191148 NA NA NA hsa-miR-338-3p CDC14A -0.948755228846395 8.99167125682392e-08 -0.494402478155925 0.00361931081486212 miRanda -0.130418406145944 0.00159230999004828 NA NA NA hsa-miR-342-3p CDC14A 0.99756868977753 9.28499866272332e-10 -0.494402478155925 0.00361931081486212 miRanda -0.16685870609157 0.000192007546026975 NA NA NA hsa-miR-424-5p CDC14A 1.48125289532143 9.10372985713165e-19 -0.494402478155925 0.00361931081486212 miRNAWalker2_validate;miRTarBase -0.172928173130629 5.03449437075804e-05 NA NA NA hsa-miR-503-5p CDC14A 2.85210590411715 1.27298190263569e-35 -0.494402478155925 0.00361931081486212 miRNAWalker2_validate;miRTarBase -0.17540701481282 2.13656281154146e-08 NA NA NA hsa-miR-576-5p CDC14A 0.940432050128373 6.90227595663302e-12 -0.494402478155925 0.00361931081486212 mirMAP -0.246988291466525 2.96049061312466e-06 NA NA NA hsa-miR-944 CDC14A 1.47323925060177 2.61626403984929e-13 -0.494402478155925 0.00361931081486212 mirMAP -0.104825570962341 0.0035535416551054 NA NA NA hsa-let-7a-3p CDC14B 0.0966652362351867 0.423761916840503 -0.230546389799305 0.0982153926411774 miRNATAP -0.183079377306946 0.00028381322047633 NA NA NA hsa-miR-146b-3p CDC14B 0.186534815310862 0.169137114997759 -0.230546389799305 0.0982153926411774 miRNATAP -0.132944819952062 0.00307748620795707 NA NA NA hsa-miR-424-5p CDC14B 1.48125289532143 9.10372985713165e-19 -0.230546389799305 0.0982153926411774 MirTarget -0.138614577262118 7.12663897533244e-05 NA NA NA hsa-miR-450b-5p CDC14B 1.25529820885833 1.18847120528666e-15 -0.230546389799305 0.0982153926411774 MirTarget;miRNATAP -0.112499428568457 0.00281684008270583 NA NA NA hsa-miR-542-3p CDC14B 0.643308814904977 8.81635403230104e-07 -0.230546389799305 0.0982153926411774 miRanda -0.158671142171972 0.000566407758024259 NA NA NA hsa-miR-576-5p CDC14B 0.940432050128373 6.90227595663302e-12 -0.230546389799305 0.0982153926411774 mirMAP -0.154204009567815 0.000382307345918673 NA NA NA hsa-miR-107 CDC16 -0.0447040564279497 0.671618791096755 -0.00328962315207804 0.967923749834277 miRanda -0.196167276244149 4.94484936917594e-09 NA NA NA hsa-miR-23b-3p CDC20 -0.497563803223134 3.31483353357535e-05 1.92394871207273 1.16026891464671e-36 miRNAWalker2_validate -0.264117983877349 7.73349718959091e-06 NA NA NA hsa-miR-30a-5p CDC20 -1.79779915425811 1.93360169837799e-26 1.92394871207273 1.16026891464671e-36 miRNAWalker2_validate -0.273923582976354 3.3579001923132e-12 NA NA NA hsa-miR-125a-5p CDC23 0.215366061934933 0.119550904549401 0.251184171797326 0.00091696769662897 miRanda -0.104715236035162 1.09512447410899e-05 NA NA NA hsa-let-7e-5p CDC25A 0.0857356192778891 0.512869729833211 0.859218190347451 1.83814454350078e-10 MirTarget;miRNATAP -0.172518053381277 0.000160643770543286 NA NA NA hsa-miR-195-5p CDC25A -1.8367376818177 6.9944883988895e-31 0.859218190347451 1.83814454350078e-10 MirTarget;miRNATAP -0.138749228690695 8.4509616893799e-05 NA NA NA hsa-miR-337-3p CDC25A -1.70091836051933 1.39844536073221e-13 0.859218190347451 1.83814454350078e-10 mirMAP -0.186111218590276 5.55732548359783e-14 NA NA NA hsa-let-7a-5p CDC25B -0.439381775414001 3.1119785480023e-05 1.62195703561335 8.32279262690367e-29 miRNAWalker2_validate -0.199816860480063 0.00169742354140644 NA NA NA hsa-miR-148a-3p CDC25B -0.428944290834563 0.00954246923521465 1.62195703561335 8.32279262690367e-29 miRNAWalker2_validate;miRNATAP -0.207437187419087 2.44696616447647e-07 25341915 Gene CDC25B might be the target gene of miR-148a according to the results of targetscan; CDC25B may be the target gene of miR-148a that plays a role in tumor suppressor gastric cancer hsa-miR-27b-3p CDC25B -0.732682718863563 2.26896143573324e-09 1.62195703561335 8.32279262690367e-29 miRNATAP -0.225524824628289 2.91259262252813e-05 NA NA NA hsa-miR-15a-5p CDC27 0.783550182002274 2.60699595655907e-11 0.348763484730986 9.5514612607646e-08 miRNATAP -0.1005909154558 2.65185869274932e-05 NA NA NA hsa-miR-497-5p CDC27 -0.966244470847844 5.26505649147857e-12 0.348763484730986 9.5514612607646e-08 miRNATAP -0.108810577863514 4.46942772093201e-08 NA NA NA hsa-miR-199a-5p CDC6 -0.364835768178638 0.0435119211101981 1.921819057412 2.04938004906943e-42 miRanda -0.171982657004893 2.77828416080196e-06 NA NA NA hsa-miR-199b-5p CDC6 -1.08432682485992 7.68241801134089e-10 1.921819057412 2.04938004906943e-42 miRanda -0.228359537025164 5.11639795406957e-10 NA NA NA hsa-miR-26a-5p CDC6 -1.09269574587169 1.24020612216319e-22 1.921819057412 2.04938004906943e-42 miRNAWalker2_validate -0.327215308198528 9.15126892344596e-09 25100863;27158389 Here it is demonstrated that miR26a and miR26b inhibit replication licensing and the proliferation migration and invasion of lung cancer cells by targeting CDC6; The current study suggests that miR26a miR26b and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets;miR 26a inhibits the proliferation of ovarian cancer cells via regulating CDC6 expression; Bioinformatics analysis revealed Cdc6 was a target gene of miR-26a; dual-luciferase assay and validation assay showed miR-26a could act on the 3'UTR of Cdc6 to regulate Cdc6 expression; These findings suggest that miR-26a may act on the 3'UTR of Cdc6 to regulate Cdc6 expression which then inhibit the proliferation of ovarian cancer cells and induce their apoptosis ; lung cancer;ovarian cancer hsa-miR-199a-5p CDC7 -0.364835768178638 0.0435119211101981 1.02536143134453 3.61024125314521e-14 MirTarget;miRanda -0.171705224670632 2.25957911872273e-07 NA NA NA hsa-miR-199b-5p CDC7 -1.08432682485992 7.68241801134089e-10 1.02536143134453 3.61024125314521e-14 MirTarget;miRanda -0.160905311615145 1.59888961957985e-06 NA NA NA hsa-miR-369-3p CDC7 -1.2344419076994 2.66882944171146e-10 1.02536143134453 3.61024125314521e-14 mirMAP -0.150769963720896 6.28403332214536e-07 NA NA NA hsa-miR-10b-5p CDK2 -0.582989331935508 4.56688330655626e-06 0.825648307855554 1.29874808659333e-17 miRNAWalker2_validate -0.159909593508401 2.19683871071865e-06 NA NA NA hsa-miR-495-3p CDK2 -1.47803501311999 6.88839745293927e-13 0.825648307855554 1.29874808659333e-17 mirMAP -0.121067515894841 3.00810482531006e-09 NA NA NA hsa-miR-101-3p CDK6 -1.91263766544878 1.50270129259053e-39 0.943799976100438 3.26010908820164e-07 mirMAP -0.330251321821837 9.84955273894382e-11 NA NA NA hsa-miR-106a-5p CDK6 0.67978010057847 0.00221925869726092 0.943799976100438 3.26010908820164e-07 mirMAP -0.270806778075969 3.01546103688573e-14 NA NA NA hsa-miR-140-3p CDK6 -0.967453553824782 7.6999446305445e-23 0.943799976100438 3.26010908820164e-07 miRNATAP -0.274830984983389 0.000572898612660903 NA NA NA hsa-miR-141-3p CDK6 0.730011517758706 0.000120338355004032 0.943799976100438 3.26010908820164e-07 TargetScan;miRNATAP -0.144552658761934 0.000685853549803452 NA NA NA hsa-miR-142-5p CDK6 0.288897753038094 0.0900009317815725 0.943799976100438 3.26010908820164e-07 PITA -0.139817988293101 0.00345142119103429 NA NA NA hsa-miR-146a-5p CDK6 -0.0201236699646614 0.905882759106561 0.943799976100438 3.26010908820164e-07 mirMAP -0.215910726342031 5.89162734992982e-06 NA NA NA hsa-miR-148a-3p CDK6 -0.428944290834563 0.00954246923521465 0.943799976100438 3.26010908820164e-07 mirMAP -0.352194126420792 2.47922792703682e-13 NA NA NA hsa-miR-148a-5p CDK6 -1.00478606532747 1.38045244999229e-07 0.943799976100438 3.26010908820164e-07 mirMAP -0.168311831982054 6.19585640247235e-05 NA NA NA hsa-miR-15a-5p CDK6 0.783550182002274 2.60699595655907e-11 0.943799976100438 3.26010908820164e-07 miRNATAP -0.285921263186907 2.61019491684346e-05 NA NA NA hsa-miR-16-1-3p CDK6 0.955017760172879 5.95379292601146e-11 0.943799976100438 3.26010908820164e-07 mirMAP -0.191844024126834 0.000473356615206941 NA NA NA hsa-miR-16-5p CDK6 0.521122945828175 1.40561786410572e-06 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase -0.390172822616052 1.63474102862122e-07 NA NA NA hsa-miR-191-5p CDK6 0.648528205617075 5.59342922179914e-07 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase -0.304048292825889 9.20052672769938e-07 NA NA NA hsa-miR-195-5p CDK6 -1.8367376818177 6.9944883988895e-31 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase -0.147548431452902 0.00221639504281517 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-200a-3p CDK6 0.607140814457753 0.00289840524858752 0.943799976100438 3.26010908820164e-07 miRNATAP -0.141449889886458 0.00036916846884784 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6 liver cancer hsa-miR-200b-3p CDK6 0.0717138787925347 0.682858087587209 0.943799976100438 3.26010908820164e-07 mirMAP -0.172143765246203 0.000203839288085545 NA NA NA hsa-miR-20b-5p CDK6 0.345967670847176 0.232014828043601 0.943799976100438 3.26010908820164e-07 mirMAP -0.319548642762033 7.55584014107553e-34 26166554 The transfection of miR-20b into EJ cells induced G1 phase cell cycle arrest via the decreased expression of cyclin D1 CDK2 and CDK6 without affecting another G1 phase cell cycle regulator cyclin E bladder cancer hsa-miR-217 CDK6 -1.35391381055929 2.42394951427902e-09 0.943799976100438 3.26010908820164e-07 mirMAP -0.101972431424956 0.00385414956789609 NA NA NA hsa-miR-218-5p CDK6 -1.0725338636959 3.61493686604269e-09 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate -0.157173497673979 0.000358234774549337 23996750 Ectopic expression of miR-218 in HepG2 cells resulted in suppressed cell proliferation and enhanced cell apoptosis as well as the down-regulation of Bmi-1 and CDK6 mRNA and protein expressions P<0.05; The low-expression of miR-218 is correlated with malignant clinicopathological characteristics of HCC and miR-218 may inhibit cell proliferation and promote cell apoptosis by down-regulating Bmi-1 and CDK6 in HCC malignant trasformation liver cancer hsa-miR-23b-3p CDK6 -0.497563803223134 3.31483353357535e-05 0.943799976100438 3.26010908820164e-07 mirMAP -0.187559518282179 0.00569215928221825 NA NA NA hsa-miR-26a-5p CDK6 -1.09269574587169 1.24020612216319e-22 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.299394118060181 1.85556297732571e-05 26314438 Maxvision immunohistochemistry technique was used to detect the expression level of CDK6 and miR-26a in tissue of 20 ENKTCL cases 10 cases of proliferative lymphadenitis and 10 samples of normal lymph node respectively; The possible role of miR-26a and its target gene CDK6 in genesis and development of ENKTCL were analyzed according to the clinical features of ENKTCL patients; Correlation analysis showed that there was significant negative correlation between miR-26a expression and CDK6 expression r = -0.54 P = 0.04 lymphoma hsa-miR-26b-5p CDK6 -0.254478038884324 0.0285227763044636 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.366507052753924 1.49769255271943e-07 NA NA NA hsa-miR-27b-3p CDK6 -0.732682718863563 2.26896143573324e-09 0.943799976100438 3.26010908820164e-07 mirMAP -0.25498599690856 9.88663275746304e-05 NA NA NA hsa-miR-27b-5p CDK6 0.580870079022649 0.000181529223377382 0.943799976100438 3.26010908820164e-07 mirMAP -0.136352328908371 0.00915378846518187 NA NA NA hsa-miR-29b-3p CDK6 -0.110721443686039 0.511264554091106 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.231353291571021 1.47948165135711e-06 23245396;25472644;26180082;23591808;27230400;20086245 The IFN-γ-induced G1-arrest of melanoma cells involves down-regulation of CDK6 which we proved to be a direct target of miR-29 in these cells;Moreover miR-29b inhibited the expression of MCL1 and CDK6;Knockdown of NTSR1 increased the expression of miR-29b-1 and miR-129-3p which were responsible for the decreased CDK6 expression;Here we have identified the oncogene cyclin-dependent protein kinase 6 CDK6 as a direct target of miR-29b in lung cancer;MiR 29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6; In this study we investigated the role of miR-29b as a novel regulator of CDK6 using bioinformatics methods; We demonstrated that CDK6 can be downregulated by miR-29b via binding to the 3'-UTR region in osteosarcoma cells; Furthermore we identified an inverse correlation between miR-29b and CDK6 protein levels in osteosarcoma tissues; The results revealed that miR-29b acts as a tumor suppressor of osteosarcoma by targeting CDK6 in the proliferation and migration processes;microRNA expression profile and identification of miR 29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma; Furthermore we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region; Inverse correlation between miR-29 and CDK6 was observed in MCL ;;;;; melanoma;colorectal cancer;glioblastoma;lung cancer;sarcoma;lymphoma hsa-miR-29c-3p CDK6 -2.08166260448948 8.3238369390898e-24 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.263284323247694 8.29389379067708e-13 26396669 Furthermore through qPCR and Western blot assays confirmed that overexpression of miR-29c reduced CDK6 mRNA and protein levels; miR-29c could inhibit the proliferation migration and invasion of bladder cancer cells via regulating CDK6 bladder cancer hsa-miR-30a-3p CDK6 -2.26144364746452 8.12421214153823e-31 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;mirMAP -0.140198240628917 0.000324956485864008 NA NA NA hsa-miR-30a-5p CDK6 -1.79779915425811 1.93360169837799e-26 0.943799976100438 3.26010908820164e-07 mirMAP -0.244091558945119 7.330875395431e-08 NA NA NA hsa-miR-30b-5p CDK6 -0.400238605368173 0.00346540992719245 0.943799976100438 3.26010908820164e-07 mirMAP -0.434806721700384 7.69264513504911e-14 NA NA NA hsa-miR-30c-5p CDK6 0.021222006155897 0.886366656528128 0.943799976100438 3.26010908820164e-07 mirMAP -0.3418227405519 2.85445288861842e-10 NA NA NA hsa-miR-30d-3p CDK6 -0.577371911152798 2.02950840095287e-06 0.943799976100438 3.26010908820164e-07 mirMAP -0.503232545055278 1.21266173811556e-14 NA NA NA hsa-miR-30d-5p CDK6 -0.38399848121878 0.000171129616944749 0.943799976100438 3.26010908820164e-07 mirMAP -0.478956981188774 1.25587674803108e-09 NA NA NA hsa-miR-30e-3p CDK6 -0.890635378639789 1.65740480611339e-16 0.943799976100438 3.26010908820164e-07 mirMAP -0.493162425301019 8.88393527920392e-12 NA NA NA hsa-miR-30e-5p CDK6 -1.02114836019762 6.81961221797866e-17 0.943799976100438 3.26010908820164e-07 mirMAP -0.527037067797998 5.6019097407655e-17 NA NA NA hsa-miR-32-5p CDK6 -0.317310201890053 0.0102525324475293 0.943799976100438 3.26010908820164e-07 miRNATAP -0.343788737898722 1.50852274763283e-07 NA NA NA hsa-miR-320a CDK6 0.801356001806321 4.91397101474502e-09 0.943799976100438 3.26010908820164e-07 PITA;miRNATAP -0.215899862858631 0.000228990035954073 NA NA NA hsa-miR-335-3p CDK6 0.336785882180547 0.0542446207938138 0.943799976100438 3.26010908820164e-07 mirMAP -0.134100857118668 0.00395950799932265 NA NA NA hsa-miR-335-5p CDK6 -1.17227779671552 1.49282618530733e-10 0.943799976100438 3.26010908820164e-07 mirMAP -0.17718916608193 4.69104859301016e-05 NA NA NA hsa-miR-340-5p CDK6 -0.608415693437977 4.44345153563513e-05 0.943799976100438 3.26010908820164e-07 mirMAP -0.17760804422206 0.00108030432977789 NA NA NA hsa-miR-34a-5p CDK6 -0.117372471043915 0.364001947180738 0.943799976100438 3.26010908820164e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.474044531250989 1.69147353058574e-14 21702042;26104764 Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004 ; bladder cancer;lung cancer hsa-miR-362-5p CDK6 0.41089772861323 0.0404254902071382 0.943799976100438 3.26010908820164e-07 mirMAP -0.260229145155647 7.00102306080077e-11 NA NA NA hsa-miR-374a-3p CDK6 -0.299190081500425 0.00682975596757891 0.943799976100438 3.26010908820164e-07 mirMAP -0.380845410382319 2.04485987693411e-07 NA NA NA hsa-miR-374a-5p CDK6 -0.621903385111545 6.61791773205282e-12 0.943799976100438 3.26010908820164e-07 mirMAP -0.405061325584562 4.73802604337785e-06 NA NA NA hsa-miR-374b-5p CDK6 -0.288413933608091 0.0041474558664058 0.943799976100438 3.26010908820164e-07 mirMAP -0.474069124376016 3.78110860368437e-09 NA NA NA hsa-miR-378a-3p CDK6 -1.50453783521372 9.41694954361173e-17 0.943799976100438 3.26010908820164e-07 mirMAP -0.209704195412153 1.273508200611e-06 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-429 CDK6 0.559451508722375 0.00563641638673083 0.943799976100438 3.26010908820164e-07 mirMAP;miRNATAP -0.106003536253203 0.0083665250305265 NA NA NA hsa-miR-497-5p CDK6 -0.966244470847844 5.26505649147857e-12 0.943799976100438 3.26010908820164e-07 miRNATAP -0.336887999296509 2.21691851621954e-09 NA NA NA hsa-miR-500a-5p CDK6 0.675401699376111 8.24389004707854e-05 0.943799976100438 3.26010908820164e-07 mirMAP -0.136463332134803 0.0038451740739746 NA NA NA hsa-miR-502-3p CDK6 -0.165138869760313 0.106881047403914 0.943799976100438 3.26010908820164e-07 PITA;miRNATAP -0.296409566969119 0.000210944839114926 NA NA NA hsa-miR-582-5p CDK6 -0.0366995972742474 0.821827119138923 0.943799976100438 3.26010908820164e-07 miRNATAP -0.222480119114911 7.9439037894028e-06 NA NA NA hsa-miR-590-3p CDK6 0.221436901462551 0.0965904764063157 0.943799976100438 3.26010908820164e-07 mirMAP;miRNATAP -0.167194733039206 0.00641945407308449 NA NA NA hsa-miR-660-5p CDK6 -0.202705992887645 0.101093376073573 0.943799976100438 3.26010908820164e-07 mirMAP -0.39601322603476 1.31183015377543e-09 NA NA NA hsa-miR-664a-3p CDK6 -0.256108763664991 0.0513188660751664 0.943799976100438 3.26010908820164e-07 mirMAP -0.32103643789594 1.87674231980515e-07 NA NA NA hsa-miR-7-1-3p CDK6 1.13646121619622 1.49823237535933e-14 0.943799976100438 3.26010908820164e-07 mirMAP -0.167417347789213 0.0018262424002125 NA NA NA hsa-miR-9-5p CDK6 1.65694862043766 2.08325802567323e-05 0.943799976100438 3.26010908820164e-07 mirMAP -0.168540643433085 5.15188603206423e-17 NA NA NA hsa-miR-107 CDK7 -0.0447040564279497 0.671618791096755 -0.251911120348687 0.00835872440760028 miRanda -0.13124654340561 0.000968575425911548 NA NA NA hsa-miR-361-5p CDK7 0.0803683277369505 0.314043140368058 -0.251911120348687 0.00835872440760028 miRanda -0.222839071957016 2.45408264755256e-05 NA NA NA hsa-miR-98-5p CDK7 0.0176698653376732 0.858271091070735 -0.251911120348687 0.00835872440760028 miRNAWalker2_validate -0.183177642705279 1.49096227819809e-05 NA NA NA hsa-let-7a-5p CDKN1A -0.439381775414001 3.1119785480023e-05 0.127907055720529 0.358633438275103 miRNAWalker2_validate;MirTarget;TargetScan -0.157887314863044 0.00607392500892242 NA NA NA hsa-let-7c-5p CDKN1A -2.07953368242668 3.46048888391218e-23 0.127907055720529 0.358633438275103 MirTarget -0.154966489020611 1.40043705353072e-08 NA NA NA hsa-let-7d-5p CDKN1A 0.481757661442508 3.66030810124939e-07 0.127907055720529 0.358633438275103 MirTarget -0.318303233510587 5.28719683231192e-07 NA NA NA hsa-let-7f-5p CDKN1A -0.441845198213823 0.00242957484218694 0.127907055720529 0.358633438275103 miRNAWalker2_validate;MirTarget -0.182282405867162 1.04368032915846e-05 NA NA NA hsa-let-7g-5p CDKN1A -0.250780249469264 0.00939610188330072 0.127907055720529 0.358633438275103 MirTarget -0.398859680782031 1.57079778109355e-10 NA NA NA hsa-let-7i-5p CDKN1A 0.249440992451337 0.00426823922424972 0.127907055720529 0.358633438275103 MirTarget -0.294915458886481 2.44467484945999e-05 NA NA NA hsa-miR-101-3p CDKN1A -1.91263766544878 1.50270129259053e-39 0.127907055720529 0.358633438275103 MirTarget -0.258645074781103 9.13055424902711e-12 NA NA NA hsa-miR-106a-5p CDKN1A 0.67978010057847 0.00221925869726092 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.127737584115643 2.20859465651693e-06 25510666 After prediction with online software we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a liver cancer hsa-miR-106b-5p CDKN1A 0.50378717276868 1.45412404526866e-05 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.395677807466644 6.77429329572222e-15 NA NA NA hsa-miR-20b-5p CDKN1A 0.345967670847176 0.232014828043601 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.104762985609593 4.52354521296224e-07 NA NA NA hsa-miR-28-5p CDKN1A -0.026996999089909 0.733047113251652 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.739238141393868 4.97263373683604e-23 NA NA NA hsa-miR-30b-3p CDKN1A -0.338530747940815 0.0223424741180399 0.127907055720529 0.358633438275103 MirTarget -0.214381215718527 1.34523563618692e-07 NA NA NA hsa-miR-335-5p CDKN1A -1.17227779671552 1.49282618530733e-10 0.127907055720529 0.358633438275103 miRNAWalker2_validate -0.233668033663431 2.16898184164444e-13 NA NA NA hsa-miR-345-5p CDKN1A 0.882162580294938 2.95895678052434e-07 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget -0.22316248649142 7.71072127808706e-11 NA NA NA hsa-miR-363-3p CDKN1A -0.608157508016978 0.0186109501272176 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase -0.113214661296052 1.07835696522481e-06 NA NA NA hsa-miR-423-5p CDKN1A 0.60141781325829 1.62940950644999e-07 0.127907055720529 0.358633438275103 MirTarget -0.249258805343378 1.73973574563061e-06 NA NA NA hsa-miR-429 CDKN1A 0.559451508722375 0.00563641638673083 0.127907055720529 0.358633438275103 miRNATAP -0.109329855441573 0.000248387440193944 NA NA NA hsa-miR-491-5p CDKN1A -0.541680329196715 0.00135829217561865 0.127907055720529 0.358633438275103 miRanda -0.113024010321719 0.00252753472048722 NA NA NA hsa-miR-582-5p CDKN1A -0.0366995972742474 0.821827119138923 0.127907055720529 0.358633438275103 miRNATAP -0.162063113723445 1.25361670221294e-05 NA NA NA hsa-miR-654-3p CDKN1A -1.77960431554497 1.76486415439529e-14 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase -0.117614114313009 3.17265104059811e-06 NA NA NA hsa-miR-93-5p CDKN1A 1.61042951896619 5.1280369606967e-24 0.127907055720529 0.358633438275103 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.131898490796649 0.000276995054107702 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC liver cancer hsa-miR-98-5p CDKN1A 0.0176698653376732 0.858271091070735 0.127907055720529 0.358633438275103 miRNAWalker2_validate;MirTarget -0.236406574284277 0.000129077758881236 NA NA NA hsa-miR-221-3p CDKN1B 0.410625614724387 0.000741090075261272 -0.21524734266819 0.0145768962530629 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.150679309763823 1.4952160991175e-06 23637992;19953484;23939688;19126397;20146005;23967190;17569667;22992757;17721077;20461750 miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression progression;;;;staging;tumorigenesis;;;;;poor survival breast cancer;glioblastoma;breast cancer;melanoma;liver cancer;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-222-3p CDKN1B 1.08197052578759 2.32604040301699e-14 -0.21524734266819 0.0145768962530629 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.149040440792648 1.14434324825478e-08 19953484;26912358;24895988;24137356;17569667;27282281;20461750 Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;Besides microvesicle marker characterization we evidenced that miR-222 exosomal expression mostly reflected its abundance in the cells of origin correctly paralleled by repression of its target genes such as p27Kip1 and induction of the PI3K/AKT pathway thus confirming its functional implication in cancer;MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;miR 222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1; miR-222 upregulation induced an enhancement of ovarian cancer cell proliferation potential possibly by downregulating its target P27Kip1; A bioinformatic analysis showed that the 3'-UTR of the P27Kip1 mRNA contained a highly-conserved putative miR-222 binding site; Luciferase reporter assays demonstrated that P27Kip1 was a direct target of miR-222; Consistently there was an inverse correlation between the P27Kip1 and miR-222 expression levels in the ovarian cancer cell lines and tissues;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;miR 222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27kip1 expression; Immunofluorescence showed that miR-222 altered the subcellular location of p27kip1 in nucleus; The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis and arrested the cells in G1 phase accompanied by more expressions of p27kip1 especially in nucleus; Taken together the results found that miR-222 induced Adr-resistance at least in part via suppressing p27kip1 expression and altering its subcellular localization and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression ;;tumorigenesis;;;drug resistance;poor survival glioblastoma;melanoma;cervical and endocervical cancer;ovarian cancer;prostate cancer;breast cancer;ovarian cancer hsa-miR-455-5p CDKN1B 1.408595672323 5.52039116456697e-22 -0.21524734266819 0.0145768962530629 miRanda;miRNATAP -0.182727098870007 1.24516427073226e-13 NA NA NA hsa-miR-221-3p CDKN1C 0.410625614724387 0.000741090075261272 -0.208101704948171 0.303726019949436 miRNAWalker2_validate;miRTarBase;miRNATAP -0.283411817847502 8.70301062500854e-05 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-222-3p CDKN1C 1.08197052578759 2.32604040301699e-14 -0.208101704948171 0.303726019949436 miRNAWalker2_validate;miRTarBase;miRNATAP -0.28425841167099 2.42560914930906e-06 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-590-3p CDKN1C 0.221436901462551 0.0965904764063157 -0.208101704948171 0.303726019949436 miRanda -0.253695862878139 0.000125690258948034 NA NA NA hsa-miR-92a-3p CDKN1C 0.994679542307232 1.32587679156217e-16 -0.208101704948171 0.303726019949436 MirTarget;miRNATAP -0.188621174786572 0.00828057340819398 NA NA NA hsa-miR-125a-5p CDKN2B 0.215366061934933 0.119550904549401 -0.566808455894765 0.177509605400259 miRanda -0.349502262154231 0.0085674250131484 NA NA NA hsa-miR-19a-3p CDKN2B 1.35800152353624 2.80940447111944e-12 -0.566808455894765 0.177509605400259 mirMAP -0.415548732128307 5.81803779351863e-06 NA NA NA hsa-miR-19b-3p CDKN2B 0.538732279378089 0.000622008277870679 -0.566808455894765 0.177509605400259 mirMAP -0.380596558104329 0.00102597918241048 NA NA NA hsa-miR-374b-5p CDKN2B -0.288413933608091 0.0041474558664058 -0.566808455894765 0.177509605400259 miRNAWalker2_validate -0.564577343855518 0.00205737706069393 NA NA NA hsa-miR-382-5p CDKN2B -0.512675955239656 0.00311534081639733 -0.566808455894765 0.177509605400259 mirMAP -0.326577358069123 0.00195583785257132 NA NA NA hsa-miR-495-3p CDKN2B -1.47803501311999 6.88839745293927e-13 -0.566808455894765 0.177509605400259 MirTarget -0.265737841666344 0.00229706019604804 NA NA NA hsa-miR-501-3p CDKN2B 0.820141346319976 1.74562930463389e-08 -0.566808455894765 0.177509605400259 PITA -0.364245102713431 0.003458352115193 NA NA NA hsa-miR-501-5p CDKN2B 1.02806906860218 1.63456814370548e-09 -0.566808455894765 0.177509605400259 mirMAP -0.362601630034175 0.000713330786726021 NA NA NA hsa-miR-576-5p CDKN2B 0.940432050128373 6.90227595663302e-12 -0.566808455894765 0.177509605400259 MirTarget -0.633612088759128 1.16104138179035e-06 NA NA NA hsa-miR-671-5p CDKN2B 1.90920358947989 6.8158317757852e-31 -0.566808455894765 0.177509605400259 PITA -0.460026012783154 9.47679025156542e-06 NA NA NA hsa-miR-139-5p CHEK1 -1.46099200329485 7.85040381494472e-22 1.20396859855604 7.17975286300605e-27 miRanda -0.178007141307805 3.06480379143231e-08 NA NA NA hsa-miR-195-5p CHEK1 -1.8367376818177 6.9944883988895e-31 1.20396859855604 7.17975286300605e-27 MirTarget;miRNATAP -0.174259778110084 7.35654556791948e-09 25840419 MiR 195 suppresses non small cell lung cancer by targeting CHEK1; We discovered that CHEK1 was a direct target of miR-195 which decreased CHEK1 expression in lung cancer cells lung squamous cell cancer hsa-miR-495-3p CHEK1 -1.47803501311999 6.88839745293927e-13 1.20396859855604 7.17975286300605e-27 MirTarget -0.100625603739772 3.70483806389657e-05 NA NA NA hsa-miR-497-5p CHEK1 -0.966244470847844 5.26505649147857e-12 1.20396859855604 7.17975286300605e-27 MirTarget;miRNATAP -0.141727865552293 8.05919355042318e-05 24464213 Checkpoint kinase 1 is negatively regulated by miR 497 in hepatocellular carcinoma; In silico analysis showed that CHEK1 was a candidate target of miR-497 which was previously found to be downregulated in HCC by us; To test whether miR-497 could bind to 3'untranslated region 3'UTR of CHEK1 luciferase reporter assay was conducted; The result revealed that miR-497 could bind to the 3'untranslated region 3'UTR of CHEK1 mRNA; Western blot showed that ectopic expression of miR-497 suppressed the CHEK1 expression and inhibition of miR-497 led to significant upregulation of CHEK1; Finally miR-497 expression was measured in the same 30 HCC samples and the correlation between miR-497 and CHEK1 was analyzed; The results indicated that miR-497 was downregulated in HCC and had a significant negative correlation with CHEK1; Taken together these results demonstrated that CHEK1 was negatively regulated by miR-497 and the overexpressed CHEK1 was resulted from the downregulated miR-497 in HCC which provided a potential molecular target for HCC therapy liver cancer hsa-let-7a-3p CREBBP 0.0966652362351867 0.423761916840503 0.0211259388253167 0.833615761874968 miRNATAP -0.141728011100707 9.23516643213276e-05 NA NA NA hsa-miR-186-5p CREBBP 0.353452958261612 0.000145058448579496 0.0211259388253167 0.833615761874968 mirMAP;miRNATAP -0.266935526900469 1.07011235526747e-08 NA NA NA hsa-miR-26b-5p CREBBP -0.254478038884324 0.0285227763044636 0.0211259388253167 0.833615761874968 miRNATAP -0.214346125460379 9.40206492009562e-09 NA NA NA hsa-miR-30d-3p CREBBP -0.577371911152798 2.02950840095287e-06 0.0211259388253167 0.833615761874968 MirTarget;miRNATAP -0.125103816738256 0.000472569063529424 NA NA NA hsa-miR-590-3p CREBBP 0.221436901462551 0.0965904764063157 0.0211259388253167 0.833615761874968 PITA;miRanda;mirMAP;miRNATAP -0.10121443711021 0.00207914002999387 NA NA NA hsa-miR-199a-5p DBF4 -0.364835768178638 0.0435119211101981 0.955563441597312 2.44873116744695e-18 miRanda -0.113349676736592 2.96818548836417e-05 NA NA NA hsa-miR-199b-5p DBF4 -1.08432682485992 7.68241801134089e-10 0.955563441597312 2.44873116744695e-18 miRanda -0.113646588536485 3.34712002685818e-05 NA NA NA hsa-miR-30a-5p DBF4 -1.79779915425811 1.93360169837799e-26 0.955563441597312 2.44873116744695e-18 MirTarget -0.135306810751893 8.73411924668954e-07 NA NA NA hsa-miR-411-5p DBF4 -2.13692124260403 3.56150106692251e-21 0.955563441597312 2.44873116744695e-18 MirTarget -0.119917061816713 6.27152907576899e-09 NA NA NA hsa-let-7a-5p E2F1 -0.439381775414001 3.1119785480023e-05 1.87871586809084 1.01618582067195e-30 miRNAWalker2_validate -0.320651072740083 6.72675752495938e-06 NA NA NA hsa-let-7e-5p E2F2 0.0857356192778891 0.512869729833211 0.403023252463145 0.0142615900158045 MirTarget -0.301382439219042 3.13748056330901e-08 NA NA NA hsa-miR-193b-3p E2F2 1.72788400801602 3.0722151264559e-21 0.403023252463145 0.0142615900158045 miRNAWalker2_validate -0.111316818843617 0.00316591748549726 NA NA NA hsa-miR-214-3p E2F2 -0.118240959890965 0.564962359782563 0.403023252463145 0.0142615900158045 mirMAP -0.173945819951115 5.52954150403577e-07 NA NA NA hsa-miR-214-5p E2F2 0.236510288548811 0.206226406026677 0.403023252463145 0.0142615900158045 MirTarget;miRNATAP -0.158715187983388 3.27289875242158e-05 NA NA NA hsa-miR-22-3p E2F2 0.00776313533473072 0.926356548861307 0.403023252463145 0.0142615900158045 miRNAWalker2_validate -0.526750855121574 7.65391064573182e-10 NA NA NA hsa-miR-2355-5p E2F2 1.47205546931107 8.65192179636668e-19 0.403023252463145 0.0142615900158045 mirMAP -0.125904901374348 0.00251110394717449 NA NA NA hsa-miR-365a-3p E2F2 0.446833934952926 0.00233857759218299 0.403023252463145 0.0142615900158045 MirTarget -0.190814534681407 8.85180667847812e-05 NA NA NA hsa-miR-432-5p E2F2 -1.37745409934142 1.95995628572162e-09 0.403023252463145 0.0142615900158045 mirMAP -0.200584727053953 3.51323709282391e-11 NA NA NA hsa-miR-539-5p E2F2 -0.15206998860136 0.492550733728996 0.403023252463145 0.0142615900158045 mirMAP -0.166006619293476 3.12822590912893e-07 NA NA NA hsa-miR-23b-3p E2F4 -0.497563803223134 3.31483353357535e-05 0.460148892715794 1.53287810825712e-09 miRNAWalker2_validate -0.174894702244308 2.19773381712947e-10 NA NA NA hsa-miR-769-5p E2F4 0.0865819375213306 0.445395188017017 0.460148892715794 1.53287810825712e-09 miRNATAP -0.106542659723632 0.000344443513183707 NA NA NA hsa-miR-205-5p E2F5 1.50759485376634 2.0003886738248e-16 -0.252434985953633 0.201378935833205 miRNAWalker2_validate;miRTarBase;miRNATAP -0.149137303159392 0.001040240141985 21454583 The expression levels of E2F1 and E2F5 were correlated inversely with that of miR-205 in melanoma cell lines; miR-205 significantly suppressed the luciferase activity of reporter plasmids containing the 3'-UTR sequences complementary to either E2F1 or E2F5; Overexpression of miR-205 in melanoma cells reduced E2F1 and E2F5 protein levels melanoma hsa-miR-140-5p EP300 -0.412389003031485 0.000136051708543369 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.141884309868302 0.00916642161638672 NA NA NA hsa-miR-181b-5p EP300 0.974255518824355 2.64876280203475e-16 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.250341020065621 1.51463026672172e-07 NA NA NA hsa-miR-182-5p EP300 1.15060905311096 6.25565852529946e-10 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate;miRNATAP -0.109993574014164 0.000382060836125653 NA NA NA hsa-miR-186-5p EP300 0.353452958261612 0.000145058448579496 -0.0380111788778681 0.77827759766468 miRNATAP -0.386320760182696 6.6698828838652e-10 NA NA NA hsa-miR-193b-3p EP300 1.72788400801602 3.0722151264559e-21 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.144257938177827 2.54219199927362e-06 NA NA NA hsa-miR-20a-5p EP300 1.1531986665452 1.02385132917958e-11 -0.0380111788778681 0.77827759766468 miRNATAP -0.261739041685133 2.59407474239911e-15 NA NA NA hsa-miR-2355-3p EP300 1.58434563546762 4.06578912176206e-18 -0.0380111788778681 0.77827759766468 MirTarget;miRNATAP -0.131467353710323 2.13937266933203e-05 NA NA NA hsa-miR-25-3p EP300 0.76549796417801 3.32282098247097e-11 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.173479800768433 0.000532079071469301 NA NA NA hsa-miR-26b-5p EP300 -0.254478038884324 0.0285227763044636 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate;miRNATAP -0.321924572744021 1.18737211357222e-10 NA NA NA hsa-miR-29b-1-5p EP300 1.39669186711325 4.36960953138935e-11 -0.0380111788778681 0.77827759766468 MirTarget -0.175659831997499 5.2666018029895e-11 NA NA NA hsa-miR-30c-5p EP300 0.021222006155897 0.886366656528128 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.354080729396632 2.09783714269189e-20 NA NA NA hsa-miR-30d-3p EP300 -0.577371911152798 2.02950840095287e-06 -0.0380111788778681 0.77827759766468 MirTarget;miRNATAP -0.181263177214702 0.000161995559394236 NA NA NA hsa-miR-339-5p EP300 1.07771430326938 2.45772601859307e-09 -0.0380111788778681 0.77827759766468 miRanda -0.252101380951511 5.72291428931759e-16 NA NA NA hsa-miR-342-3p EP300 0.99756868977753 9.28499866272332e-10 -0.0380111788778681 0.77827759766468 MirTarget;PITA;miRanda;miRNATAP -0.275927662915398 1.41235573597807e-15 NA NA NA hsa-miR-361-3p EP300 0.272298288982435 0.0147874880476998 -0.0380111788778681 0.77827759766468 PITA -0.220028179879572 2.87377466725932e-05 NA NA NA hsa-miR-374b-5p EP300 -0.288413933608091 0.0041474558664058 -0.0380111788778681 0.77827759766468 mirMAP;miRNATAP -0.289679382753077 6.67702137205187e-07 NA NA NA hsa-miR-582-3p EP300 -0.248056267546012 0.143798829508405 -0.0380111788778681 0.77827759766468 MirTarget;PITA -0.110822669216861 0.00136211075647265 NA NA NA hsa-miR-590-3p EP300 0.221436901462551 0.0965904764063157 -0.0380111788778681 0.77827759766468 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.124953760048753 0.00471850055107272 NA NA NA hsa-miR-92a-3p EP300 0.994679542307232 1.32587679156217e-16 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.192864139618897 4.68840854466291e-05 NA NA NA hsa-miR-96-5p EP300 1.42326703011157 4.39736150032373e-14 -0.0380111788778681 0.77827759766468 TargetScan;miRNATAP -0.119689767979309 7.57146931270777e-05 NA NA NA hsa-miR-125a-5p ESPL1 0.215366061934933 0.119550904549401 0.116054321735766 0.475591059661232 miRanda -0.209110424079123 4.32059551609535e-05 NA NA NA hsa-miR-127-3p ESPL1 -1.47175957435172 9.8707469067377e-14 0.116054321735766 0.475591059661232 miRanda -0.146877570407367 2.37194997013605e-05 NA NA NA hsa-miR-193b-3p ESPL1 1.72788400801602 3.0722151264559e-21 0.116054321735766 0.475591059661232 miRNAWalker2_validate -0.106452628771774 0.00423660506886689 NA NA NA hsa-miR-148a-3p GADD45A -0.428944290834563 0.00954246923521465 -0.148778543104967 0.244563831657349 MirTarget;miRNATAP -0.115529771802971 0.000569454583886927 NA NA NA hsa-miR-148b-3p GADD45A 0.386859166050437 4.6728211830726e-06 -0.148778543104967 0.244563831657349 MirTarget -0.297536185776573 6.20121677211309e-06 NA NA NA hsa-miR-152-3p GADD45A -0.382486223604156 0.00710736505198702 -0.148778543104967 0.244563831657349 MirTarget -0.124908349912319 0.00141434525214503 NA NA NA hsa-miR-1976 GADD45B 0.638808083289405 2.94840228896364e-07 -1.29500058031274 1.88372965534317e-17 miRNATAP -0.163735681565526 0.00273735021269302 NA NA NA hsa-miR-324-3p GADD45B 0.867391246413545 3.63808540490361e-10 -1.29500058031274 1.88372965534317e-17 MirTarget;miRNATAP -0.456604551243598 2.13998090154516e-22 NA NA NA hsa-miR-590-3p GADD45B 0.221436901462551 0.0965904764063157 -1.29500058031274 1.88372965534317e-17 miRanda -0.163308519334935 0.00155213230880389 NA NA NA hsa-miR-107 GADD45G -0.0447040564279497 0.671618791096755 -1.08524974570121 1.91330427119552e-06 miRanda -0.261360902067525 0.00649010053220016 NA NA NA hsa-miR-320b GADD45G 1.23473838180754 3.04337566045537e-14 -1.08524974570121 1.91330427119552e-06 miRanda -0.177971631376559 0.00309864212413347 NA NA NA hsa-miR-421 GADD45G 0.945488088619653 2.35762398527362e-09 -1.08524974570121 1.91330427119552e-06 miRanda -0.165999925954088 0.00807659341669784 NA NA NA hsa-miR-146b-5p GSK3B 0.917975986853978 3.33749259316025e-09 0.343238217842623 0.000162620715851218 miRanda -0.132473733778903 1.22425435698654e-07 NA NA NA hsa-miR-155-5p GSK3B 0.533437622040649 0.00248671179205372 0.343238217842623 0.000162620715851218 miRNAWalker2_validate;miRNATAP -0.129703405382586 5.34297193283262e-09 NA NA NA hsa-miR-181a-5p GSK3B 0.819060835827404 1.38616688310277e-13 0.343238217842623 0.000162620715851218 mirMAP -0.129983989338606 0.00022139654686707 NA NA NA hsa-miR-181c-5p GSK3B -0.168991199007857 0.196949106150297 0.343238217842623 0.000162620715851218 mirMAP -0.100996413243857 0.000916035275097975 NA NA NA hsa-miR-19b-3p GSK3B 0.538732279378089 0.000622008277870679 0.343238217842623 0.000162620715851218 mirMAP -0.150537422390616 1.39629849063498e-09 NA NA NA hsa-miR-26b-5p GSK3B -0.254478038884324 0.0285227763044636 0.343238217842623 0.000162620715851218 miRNATAP -0.183171373213342 7.56842885965509e-08 NA NA NA hsa-miR-29b-3p GSK3B -0.110721443686039 0.511264554091106 0.343238217842623 0.000162620715851218 miRTarBase;miRNATAP -0.15553953034104 2.18389788804596e-11 NA NA NA hsa-miR-30d-3p GSK3B -0.577371911152798 2.02950840095287e-06 0.343238217842623 0.000162620715851218 miRNATAP -0.131426620771029 5.32900605744827e-05 NA NA NA hsa-miR-320a GSK3B 0.801356001806321 4.91397101474502e-09 0.343238217842623 0.000162620715851218 miRanda;mirMAP -0.118878412659656 3.17737768709188e-05 NA NA NA hsa-miR-342-3p GSK3B 0.99756868977753 9.28499866272332e-10 0.343238217842623 0.000162620715851218 miRanda -0.148362741070108 3.75779017463144e-10 NA NA NA hsa-miR-362-5p GSK3B 0.41089772861323 0.0404254902071382 0.343238217842623 0.000162620715851218 miRNATAP -0.127816847863223 5.47709912360141e-11 NA NA NA hsa-miR-374a-5p GSK3B -0.621903385111545 6.61791773205282e-12 0.343238217842623 0.000162620715851218 mirMAP -0.147719372342419 0.000672011632138884 NA NA NA hsa-miR-374b-5p GSK3B -0.288413933608091 0.0041474558664058 0.343238217842623 0.000162620715851218 mirMAP -0.228003781574329 6.67084161350237e-09 NA NA NA hsa-miR-664a-3p GSK3B -0.256108763664991 0.0513188660751664 0.343238217842623 0.000162620715851218 mirMAP -0.163651290979419 5.20958641528547e-08 NA NA NA hsa-miR-139-5p MAD2L1 -1.46099200329485 7.85040381494472e-22 1.31598344787194 2.23296117935679e-24 miRanda -0.23799986330838 8.21743682985319e-11 NA NA NA hsa-miR-127-5p MCM2 -0.605739525751187 0.000636065602565634 1.65851749694871 1.21529445777254e-30 miRNATAP -0.157820740875189 2.32558657191172e-05 NA NA NA hsa-miR-139-5p MCM2 -1.46099200329485 7.85040381494472e-22 1.65851749694871 1.21529445777254e-30 miRanda -0.341126211699593 7.45865025741772e-17 NA NA NA hsa-miR-338-3p MCM4 -0.948755228846395 8.99167125682392e-08 1.04546514751638 1.52109492147256e-17 MirTarget;miRanda -0.193161803248233 1.71812610632412e-10 NA NA NA hsa-miR-34a-5p MCM4 -0.117372471043915 0.364001947180738 1.04546514751638 1.52109492147256e-17 miRNAWalker2_validate -0.119607823731978 0.00530131327779481 NA NA NA hsa-miR-369-3p MCM6 -1.2344419076994 2.66882944171146e-10 0.936497616092439 4.50408444326268e-17 mirMAP -0.148490481661836 2.60019297244467e-09 NA NA NA hsa-miR-493-5p MCM6 -0.471586962917071 0.0221327433064002 0.936497616092439 4.50408444326268e-17 MirTarget -0.116815835829507 1.30504242094782e-06 NA NA NA hsa-let-7b-5p MCM7 -0.2489842756826 0.0211384499461719 1.16494147688151 7.85221503407817e-22 miRNAWalker2_validate -0.156628514656083 0.00226516585236242 NA NA NA hsa-miR-145-5p MDM2 -0.46917511594055 0.000685297625493134 -0.187608646962063 0.0757851997933277 miRNAWalker2_validate -0.120282167205982 0.000285646785971262 NA NA NA hsa-miR-181a-2-3p MDM2 0.562132917934234 4.79313448225408e-05 -0.187608646962063 0.0757851997933277 mirMAP -0.183010150101776 2.34295977089442e-08 NA NA NA hsa-miR-450a-5p MDM2 1.74695686398479 4.62583996044297e-22 -0.187608646962063 0.0757851997933277 mirMAP -0.133291140860781 3.19028333188365e-08 NA NA NA hsa-let-7c-5p MYC -2.07953368242668 3.46048888391218e-23 -0.32772106147221 0.0189770115533449 miRNAWalker2_validate;miRTarBase -0.107421906050131 0.000103545158346461 22128178 MicroRNA let 7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells prostate cancer hsa-miR-34a-5p MYC -0.117372471043915 0.364001947180738 -0.32772106147221 0.0189770115533449 miRNAWalker2_validate;miRTarBase -0.157674637324898 0.000854501792660625 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-154-5p PCNA -1.13666358116162 1.83050913061273e-08 0.882506891114865 1.32654461429473e-15 miRNATAP -0.104156095040001 1.74036427082141e-05 NA NA NA hsa-miR-338-5p PCNA -1.71946558699173 2.62649071488641e-23 0.882506891114865 1.32654461429473e-15 PITA -0.126898531790768 3.04620801491555e-06 NA NA NA hsa-miR-100-5p PLK1 -1.85857794619369 1.248973638996e-25 2.05817601466953 2.75092749049503e-47 miRNAWalker2_validate;miRTarBase -0.211512108307072 4.76722561425457e-09 23151088;22246341;23842624;25537513;22120675;21636267 MicroRNA 100 is a potential molecular marker of non small cell lung cancer and functions as a tumor suppressor by targeting polo like kinase 1; By using microRNA miR target prediction algorithms we identified miR-100 that might potentially bind the 3'-untranslated region of PLK1 transcripts; The purpose of this study was to investigate the roles of miR-100 and its association with PLK1 in NSCLC development; Finally the effects of miR-100 expression on growth apoptosis and cell cycle of NSCLC cells by posttranscriptionally regulating PLK1 expression were determined; Meanwhile miR-100 mimics could significantly inhibit PLK1 mRNA and protein expression and reduce the luciferase activity of a PLK1 3' untranslated region-based reporter construct in A549 cells; Furthermore small interfering RNA siRNA-mediated PLK1 downregulation could mimic the effects of miR-100 mimics while PLK1 overexpression could partially rescue the phenotypical changes of NSCLC cells induced by miR-100 mimics; Our findings indicate that low miR-100 may be a poor prognostic factor for NSCLC patients and functions as a tumor suppressor by posttranscriptionally regulating PLK1 expression;Together these results suggest that low miR-100 expression may be an independent poor prognostic factor and miR-100 can function as a tumor suppressor by targeting PLK1 in human EOCs;In HCC tissues miR-100 expression was inversely correlated with the expression of plk1 protein r = -0.418; P = 0.029; Therefore downregulation of miR-100 was correlated with progressive pathological feature and poor prognosis in HCC patients and miR-100 could function as a tumor suppressor by targeting plk1;Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 Plk1 down-regulation;MiR 100 resensitizes docetaxel resistant human lung adenocarcinoma cells SPC A1 to docetaxel by targeting Plk1; Knock-down of Plk1 which was a direct target of miR-100 yielded similar effects as that of ectopic miR-100 expression; The inverse correlation between miR-100 and Plk1 expression was also detected in nude mice SPC-A1/DTX tumor xenografts and clinical lung adenocarcinoma tissues and was proved to be related with the in vivo response to docetaxel; Thus our results suggested that down-regulation of miR-100 could lead to Plk1 over-expression and eventually to docetaxel chemoresistance of human lung adenocarcinoma;Reduced miR 100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein; Through modulating miR-100 expression using miR-100 inhibitor or mimic in vitro cell growth cycle and apoptosis were tested separately by MTT or flow cytometry and meanwhile Polo-like kinase1 PLK1 mRNA and protein expressions were detected by qRT-PCR and immunoblotting; The expression of PLK1 in 125 cervical tissues was also examined by immunohistochemical staining and the correlation between miR-100 and PLK1 expression in the same tissues was analysed; The modulation of miR-100 expression remarkably influenced cell proliferation cycle and apoptosis as well as the level of PLK1 protein but not mRNA in vitro experiments; PLK1 expression was negatively correlated with miR-100 expression in CIN3 and cervical cancer tissues; The reduced miR-100 expression participates in the development of cervical cancer at least partly through loss of inhibition to target gene PLK1 which probably occurs in a relative late phase of carcinogenesis ;;progression;worse prognosis;;drug resistance;tumorigenesis lung squamous cell cancer;ovarian cancer;liver cancer;breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-486-5p PLK1 -1.70341092285685 6.64232609099498e-14 2.05817601466953 2.75092749049503e-47 miRanda -0.122956027602657 2.41703552495659e-05 NA NA NA hsa-miR-101-5p PRKDC -1.429324744941 4.00032662184937e-18 0.686787190822317 5.06119769382703e-09 miRNAWalker2_validate;miRTarBase -0.106341039944399 0.000475452075553351 22014955 Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299 H1975 and A549 cells it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells lung squamous cell cancer hsa-let-7b-5p PTTG1 -0.2489842756826 0.0211384499461719 1.38448807554391 3.5138577587937e-18 miRNAWalker2_validate -0.323162805448218 1.14071715571153e-06 NA NA NA hsa-miR-26a-5p PTTG1 -1.09269574587169 1.24020612216319e-22 1.38448807554391 3.5138577587937e-18 miRNAWalker2_validate -0.364999947165645 2.41008342471794e-09 NA NA NA hsa-miR-139-5p RAD21 -1.46099200329485 7.85040381494472e-22 0.645202641172029 1.80982529755565e-14 miRanda -0.162655978570738 2.6665705125276e-12 NA NA NA hsa-miR-140-5p RAD21 -0.412389003031485 0.000136051708543369 0.645202641172029 1.80982529755565e-14 miRanda -0.110958298054607 0.00141913664276234 NA NA NA hsa-miR-199a-5p RAD21 -0.364835768178638 0.0435119211101981 0.645202641172029 1.80982529755565e-14 miRanda -0.112137380703865 4.94729653936104e-08 NA NA NA hsa-miR-199b-5p RAD21 -1.08432682485992 7.68241801134089e-10 0.645202641172029 1.80982529755565e-14 miRanda -0.13423184292552 7.65178301460932e-11 NA NA NA hsa-miR-125a-5p RB1 0.215366061934933 0.119550904549401 -0.0268480421254154 0.835486401596562 miRanda -0.253535939886051 2.72459828390305e-10 NA NA NA hsa-miR-1301-3p RB1 2.13677668481885 6.11093268540831e-44 -0.0268480421254154 0.835486401596562 MirTarget -0.163424108027658 9.15083774590862e-07 NA NA NA hsa-miR-186-5p RB1 0.353452958261612 0.000145058448579496 -0.0268480421254154 0.835486401596562 mirMAP -0.216046082714465 0.000367266126768344 NA NA NA hsa-miR-199a-5p RB1 -0.364835768178638 0.0435119211101981 -0.0268480421254154 0.835486401596562 miRanda -0.152257242544093 8.05128748947185e-07 NA NA NA hsa-miR-199b-5p RB1 -1.08432682485992 7.68241801134089e-10 -0.0268480421254154 0.835486401596562 miRanda -0.156754991647435 4.74582145718582e-07 NA NA NA hsa-miR-26b-5p RB1 -0.254478038884324 0.0285227763044636 -0.0268480421254154 0.835486401596562 MirTarget -0.18955260127634 9.15697343051614e-05 NA NA NA hsa-miR-28-3p RB1 0.459875450032895 3.47095927872566e-07 -0.0268480421254154 0.835486401596562 PITA -0.255336448878595 3.92691253197471e-05 NA NA NA hsa-miR-29a-5p RB1 0.323252792625584 0.0370417231222825 -0.0268480421254154 0.835486401596562 MirTarget -0.103420566389121 0.00438695089324494 NA NA NA hsa-miR-30d-3p RB1 -0.577371911152798 2.02950840095287e-06 -0.0268480421254154 0.835486401596562 MirTarget -0.13872932385174 0.0026336440235155 NA NA NA hsa-miR-342-3p RB1 0.99756868977753 9.28499866272332e-10 -0.0268480421254154 0.835486401596562 miRanda -0.136602158836996 5.4234278229599e-05 NA NA NA hsa-miR-361-5p RB1 0.0803683277369505 0.314043140368058 -0.0268480421254154 0.835486401596562 miRanda -0.230820774412484 0.00126654433157141 NA NA NA hsa-miR-374a-3p RB1 -0.299190081500425 0.00682975596757891 -0.0268480421254154 0.835486401596562 mirMAP -0.208255698115081 4.22650679177648e-05 NA NA NA hsa-miR-576-5p RB1 0.940432050128373 6.90227595663302e-12 -0.0268480421254154 0.835486401596562 MirTarget -0.123917365074315 0.00208124875438431 NA NA NA hsa-miR-93-5p RB1 1.61042951896619 5.1280369606967e-24 -0.0268480421254154 0.835486401596562 miRNAWalker2_validate;MirTarget;miRNATAP -0.159205845891274 1.99263368143055e-06 NA NA NA hsa-miR-199a-5p RBL1 -0.364835768178638 0.0435119211101981 0.661862629855869 2.83210541337127e-05 miRanda -0.192350802150513 4.30235952663098e-07 NA NA NA hsa-miR-199b-5p RBL1 -1.08432682485992 7.68241801134089e-10 0.661862629855869 2.83210541337127e-05 miRanda -0.215585193511816 1.79370314243358e-08 NA NA NA hsa-miR-495-3p RBL1 -1.47803501311999 6.88839745293927e-13 0.661862629855869 2.83210541337127e-05 mirMAP -0.164165260825258 5.35311611367621e-07 NA NA NA hsa-miR-17-5p RBL2 1.41924888736771 2.75805544953758e-18 -0.246969867748111 0.01592378348393 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.143700264319262 4.37673737340372e-08 NA NA NA hsa-miR-20a-5p RBL2 1.1531986665452 1.02385132917958e-11 -0.246969867748111 0.01592378348393 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.147438220726723 7.40385047142412e-09 NA NA NA hsa-miR-576-5p RBL2 0.940432050128373 6.90227595663302e-12 -0.246969867748111 0.01592378348393 MirTarget;PITA -0.178415823365207 1.66822901246308e-08 NA NA NA hsa-miR-93-5p RBL2 1.61042951896619 5.1280369606967e-24 -0.246969867748111 0.01592378348393 MirTarget;miRNATAP -0.128261961743392 1.38907217254418e-06 NA NA NA hsa-miR-34a-5p SFN -0.117372471043915 0.364001947180738 0.658921611118602 0.00447943363250081 miRNAWalker2_validate -0.273754495018025 0.00049656562222554 NA NA NA hsa-miR-130b-3p SKP1 1.44628430084411 9.13980959861273e-24 -0.426414078743471 1.8274515909563e-09 MirTarget -0.111425580134606 6.14058372927867e-08 NA NA NA hsa-miR-148b-3p SKP1 0.386859166050437 4.6728211830726e-06 -0.426414078743471 1.8274515909563e-09 MirTarget -0.113875723617554 0.00219226586497516 NA NA NA hsa-miR-152-3p SKP1 -0.382486223604156 0.00710736505198702 -0.426414078743471 1.8274515909563e-09 MirTarget -0.114177290928382 1.6385750636398e-07 NA NA NA hsa-miR-26b-5p SKP2 -0.254478038884324 0.0285227763044636 0.847981453329814 1.12276777710769e-09 MirTarget -0.193948282898621 0.00026477561389391 NA NA NA hsa-miR-30a-5p SKP2 -1.79779915425811 1.93360169837799e-26 0.847981453329814 1.12276777710769e-09 MirTarget;miRNATAP -0.182102888515017 1.13631104169536e-07 NA NA NA hsa-miR-30b-5p SKP2 -0.400238605368173 0.00346540992719245 0.847981453329814 1.12276777710769e-09 MirTarget;miRNATAP -0.207530127998154 3.52157414137091e-06 NA NA NA hsa-miR-30c-5p SKP2 0.021222006155897 0.886366656528128 0.847981453329814 1.12276777710769e-09 MirTarget;miRNATAP -0.208655949233282 4.37918019342386e-07 NA NA NA hsa-miR-340-3p SKP2 0.289340144425255 0.0371281333347226 0.847981453329814 1.12276777710769e-09 MirTarget -0.123695968573623 0.0054513901639686 25151966 At the same time miR-340 induces the stabilization of p27 by targeting SKP2 the key posttranslational regulator of p27; Accordingly the inhibition of either PUM1 or SKP2 partially recapitulates the miR-340 effect on cell proliferation and apoptosis lung squamous cell cancer hsa-let-7a-3p SMAD2 0.0966652362351867 0.423761916840503 0.0243635060778491 0.76464000338556 mirMAP -0.120201003720566 4.00233873380995e-05 NA NA NA hsa-miR-181a-5p SMAD2 0.819060835827404 1.38616688310277e-13 0.0243635060778491 0.76464000338556 mirMAP -0.123663686344939 7.35992784180675e-05 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 0.974255518824355 2.64876280203475e-16 0.0243635060778491 0.76464000338556 mirMAP -0.187179272190298 4.69209630284474e-11 NA NA NA hsa-miR-455-5p SMAD2 1.408595672323 5.52039116456697e-22 0.0243635060778491 0.76464000338556 miRanda -0.146407779382659 1.44497506412449e-10 NA NA NA hsa-miR-145-5p SMAD3 -0.46917511594055 0.000685297625493134 -0.143490080047147 0.241618109620266 MirTarget;miRNATAP -0.115484614688291 0.00271929213208624 27237033 MiR 145 and miR 203 represses TGF β induced epithelial mesenchymal transition and invasion by inhibiting SMAD3 in non small cell lung cancer cells; siRNA-mediated knockdown of SMAD3 copied the phenotype of miR-145 and miR-203 overexpression in A549 and 95C cells; MiR-145 and miR-203 inhibited TGF-β-induced EMT and invasion through repression of SMAD3 in NSCLC cells lung squamous cell cancer hsa-miR-155-5p SMAD3 0.533437622040649 0.00248671179205372 -0.143490080047147 0.241618109620266 miRNAWalker2_validate -0.125492484204873 2.91075561128582e-05 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-186-5p SMAD3 0.353452958261612 0.000145058448579496 -0.143490080047147 0.241618109620266 mirMAP -0.183402338959526 0.00144579229064042 NA NA NA hsa-miR-424-5p SMAD3 1.48125289532143 9.10372985713165e-19 -0.143490080047147 0.241618109620266 MirTarget -0.158147445199969 2.11197443864582e-07 27655675 miR 424 5p promotes proliferation of gastric cancer by targeting Smad3 through TGF β signaling pathway; QRT-PCR was used to determine the expression levels of miR-424-5p and Smad3; Luciferase reporter assay and western blotting were used to prove that Smad3 was one of the direct targets of miR-424-5p; In addition luciferase reporter assay and western blotting assay revealed that Smad3 was a direct target of miR-424-5p; Over-expression of Smad3 could partially reverse the effects of miR-424-5p on GC cell proliferation; Our study further revealed that miR-424-5p could inhibit TGF-β signaling pathway by Smad3 gastric cancer hsa-let-7a-3p SMAD4 0.0966652362351867 0.423761916840503 -0.429721565372713 9.05223747485839e-07 mirMAP -0.127673799060679 6.14893432718486e-05 NA NA NA hsa-miR-130a-3p SMAD4 0.67051191119964 4.89747518735144e-06 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate;miRNATAP -0.144664759620316 1.85930895184609e-08 NA NA NA hsa-miR-18a-5p SMAD4 1.65455873230328 3.76457892277775e-20 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate -0.132804055287407 4.94433335605224e-11 NA NA NA hsa-miR-19a-3p SMAD4 1.35800152353624 2.80940447111944e-12 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.111631809114141 5.01550217662971e-09 NA NA NA hsa-miR-21-3p SMAD4 1.25126438776674 2.4124216716282e-17 -0.429721565372713 9.05223747485839e-07 mirMAP -0.132998757674157 1.0204793984454e-07 NA NA NA hsa-miR-224-5p SMAD4 1.94534596857416 1.88348779207332e-19 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate;miRTarBase;MirTarget -0.104382574165612 6.63646727576293e-10 24817781;24152489;26187928;23913306;25804630;26307684 Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels and inhibited the formation of actin filaments;In addition the regulation of SMAD4 by miR-224 was evaluated by qRT-PCR Western blotting and luciferase reporter assays; Furthermore the over-expression of miR-224 in CRC cell lines decreased SMAD4 expression at the translational level and decreased SMAD4-driven luciferase-reporter activity;Increased miR-224 expression promotes cell migration invasion and proliferation by directly targeting the tumor suppressors TNFα-induced protein 1 TNFAIP1 and SMAD4; Up-regulated miR-224 thus facilitates tumor progression by shifting the equilibrium of the partially antagonist functions of SMAD4 and TNFAIP1 toward enhanced invasion and growth in NSCLC;Our in vitro study demonstrated that miR-224 played an oncogenic role in hepatoma cell migration and tumor formation through silencing its target gene Smad4; A noncanonical pathway links autophagy miR-224 Smad4 and HBV-associated HCC;We identified SMAD4 as a miR-224 target and observed negative correlation Spearman Rs=-0.44 p<0.0001 between SMAD4 and miR-224 expression in clinical samples; In the TCGA set combined analysis of miR-224 with SMAD4 expression enhanced correlation with survival HR 4.12 95% CI 1.1 to 15.41 p=0.0175; MiR-224 promotes CRC metastasis at least in part through the regulation of SMAD4;We further demonstrated that miR-224 functions as an oncogene in NSCLC by directly targeting TNFAIP1 and SMAD4 ;;cell migration;progression;cell migration;poor survival;metastasis; colorectal cancer;colorectal cancer;lung squamous cell cancer;liver cancer;colorectal cancer;lung cancer hsa-miR-2355-5p SMAD4 1.47205546931107 8.65192179636668e-19 -0.429721565372713 9.05223747485839e-07 MirTarget -0.198974232428425 2.21498106355127e-20 NA NA NA hsa-miR-27a-3p SMAD4 0.348456440505425 0.00126682892514312 -0.429721565372713 9.05223747485839e-07 MirTarget -0.157382002902766 9.11244451316926e-06 NA NA NA hsa-miR-450b-5p SMAD4 1.25529820885833 1.18847120528666e-15 -0.429721565372713 9.05223747485839e-07 mirMAP -0.113363230314613 1.66484502341078e-06 NA NA NA hsa-miR-454-3p SMAD4 1.54137391927201 4.15861570449376e-20 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate;miRNATAP -0.107809125022266 8.27427228720796e-07 NA NA NA hsa-miR-576-5p SMAD4 0.940432050128373 6.90227595663302e-12 -0.429721565372713 9.05223747485839e-07 mirMAP -0.137995054888109 4.27825973334458e-07 NA NA NA hsa-miR-590-5p SMAD4 0.763025362395968 3.65305892505623e-09 -0.429721565372713 9.05223747485839e-07 miRanda -0.107285938961663 0.000249372347039553 NA NA NA hsa-miR-103a-2-5p SMC1A 1.37988337975616 6.74852943995612e-08 0.238379624133141 0.020553539443373 mirMAP -0.105739720386312 1.40547471335301e-08 NA NA NA hsa-miR-130a-3p SMC1A 0.67051191119964 4.89747518735144e-06 0.238379624133141 0.020553539443373 mirMAP -0.142171737893363 2.41140684977469e-06 NA NA NA hsa-miR-136-5p SMC1A -1.02992475853448 5.0914989178544e-07 0.238379624133141 0.020553539443373 mirMAP -0.119266516612877 2.43074849915753e-08 NA NA NA hsa-miR-145-5p SMC1A -0.46917511594055 0.000685297625493134 0.238379624133141 0.020553539443373 mirMAP -0.128144202391056 7.21953734027403e-05 NA NA NA hsa-miR-660-5p SMC1A -0.202705992887645 0.101093376073573 0.238379624133141 0.020553539443373 mirMAP -0.10334368942553 0.0045618852149896 NA NA NA hsa-miR-664a-3p SMC1A -0.256108763664991 0.0513188660751664 0.238379624133141 0.020553539443373 mirMAP -0.139684951715827 4.15703919790554e-05 NA NA NA hsa-miR-139-5p SMC3 -1.46099200329485 7.85040381494472e-22 0.231111063000296 0.018077810343035 miRanda -0.101211232571941 0.000158501239755124 NA NA NA hsa-miR-139-5p STAG1 -1.46099200329485 7.85040381494472e-22 0.03838311360344 0.767918484911069 miRanda -0.106717264339297 0.00279112452404829 NA NA NA hsa-miR-181a-5p STAG1 0.819060835827404 1.38616688310277e-13 0.03838311360344 0.767918484911069 miRNATAP -0.165424160654146 0.00096257047594671 NA NA NA hsa-miR-181b-5p STAG1 0.974255518824355 2.64876280203475e-16 0.03838311360344 0.767918484911069 miRNATAP -0.195985604479202 2.15925271996291e-05 NA NA NA hsa-miR-186-5p STAG1 0.353452958261612 0.000145058448579496 0.03838311360344 0.767918484911069 mirMAP -0.26311980426844 1.52705698430717e-05 NA NA NA hsa-miR-26b-5p STAG1 -0.254478038884324 0.0285227763044636 0.03838311360344 0.767918484911069 miRNAWalker2_validate -0.240945632050991 6.89510917781464e-07 NA NA NA hsa-miR-30b-5p STAG1 -0.400238605368173 0.00346540992719245 0.03838311360344 0.767918484911069 MirTarget -0.177534506219561 1.58054861029898e-05 NA NA NA hsa-miR-30c-5p STAG1 0.021222006155897 0.886366656528128 0.03838311360344 0.767918484911069 MirTarget -0.225646336247227 2.20739349327308e-09 NA NA NA hsa-miR-103a-2-5p STAG2 1.37988337975616 6.74852943995612e-08 0.124758785907763 0.186680178707183 MirTarget -0.107388527787903 2.73574796843728e-10 NA NA NA hsa-miR-181a-5p STAG2 0.819060835827404 1.38616688310277e-13 0.124758785907763 0.186680178707183 miRNAWalker2_validate -0.151258483323833 3.02425707753316e-05 NA NA NA hsa-miR-29b-3p STAG2 -0.110721443686039 0.511264554091106 0.124758785907763 0.186680178707183 MirTarget;miRNATAP -0.1585707063757 3.89633942364688e-11 NA NA NA hsa-miR-30b-5p STAG2 -0.400238605368173 0.00346540992719245 0.124758785907763 0.186680178707183 MirTarget;mirMAP -0.102619122834435 0.00061101279790969 NA NA NA hsa-miR-30c-5p STAG2 0.021222006155897 0.886366656528128 0.124758785907763 0.186680178707183 MirTarget;mirMAP;miRNATAP -0.154993324760876 1.60076438176244e-08 NA NA NA hsa-miR-338-3p STAG2 -0.948755228846395 8.99167125682392e-08 0.124758785907763 0.186680178707183 miRanda -0.177305709091123 1.70282827067087e-15 NA NA NA hsa-miR-342-3p STAG2 0.99756868977753 9.28499866272332e-10 0.124758785907763 0.186680178707183 miRanda -0.128861968856278 1.58808799589635e-07 NA NA NA hsa-miR-34a-5p STAG2 -0.117372471043915 0.364001947180738 0.124758785907763 0.186680178707183 miRNAWalker2_validate;miRNATAP -0.20026822185475 1.84977268157584e-10 NA NA NA hsa-miR-664a-3p STAG2 -0.256108763664991 0.0513188660751664 0.124758785907763 0.186680178707183 mirMAP -0.116407799499695 0.000196108967807987 NA NA NA hsa-miR-30a-5p TFDP1 -1.79779915425811 1.93360169837799e-26 0.247359691303701 0.010818277948758 MirTarget;miRNATAP -0.112671547311556 1.83160590224895e-06 NA NA NA hsa-miR-30b-5p TFDP1 -0.400238605368173 0.00346540992719245 0.247359691303701 0.010818277948758 MirTarget -0.111643300189791 0.000291833091435077 NA NA NA hsa-miR-30d-5p TFDP1 -0.38399848121878 0.000171129616944749 0.247359691303701 0.010818277948758 MirTarget;miRNATAP -0.107581805897102 0.00960848150846495 NA NA NA hsa-miR-374a-5p TFDP1 -0.621903385111545 6.61791773205282e-12 0.247359691303701 0.010818277948758 MirTarget -0.135663411488111 0.0033425311586121 NA NA NA hsa-miR-374b-5p TFDP1 -0.288413933608091 0.0041474558664058 0.247359691303701 0.010818277948758 MirTarget -0.177916775624634 2.38229744260992e-05 NA NA NA hsa-miR-126-5p TFDP2 -0.953529188793816 7.91719143295591e-16 0.425669422468068 0.0013716846266445 mirMAP -0.132764163957395 0.00562204447431945 NA NA NA hsa-miR-132-3p TFDP2 0.237841736463996 0.00653466538179383 0.425669422468068 0.0013716846266445 mirMAP -0.20429718438079 0.00235393596862557 NA NA NA hsa-miR-193b-5p TFDP2 1.10486595354104 6.41489920661805e-11 0.425669422468068 0.0013716846266445 mirMAP -0.159760614466275 1.88020745265091e-06 NA NA NA hsa-miR-212-3p TFDP2 0.0427493354176791 0.789608223138427 0.425669422468068 0.0013716846266445 mirMAP -0.100500103608665 0.00574015101281685 NA NA NA hsa-miR-2355-5p TFDP2 1.47205546931107 8.65192179636668e-19 0.425669422468068 0.0013716846266445 mirMAP -0.108930931815177 0.0012363666751778 NA NA NA hsa-miR-299-5p TFDP2 -1.92445654064493 1.52402531359074e-16 0.425669422468068 0.0013716846266445 mirMAP -0.137575017762971 9.2930129845431e-09 NA NA NA hsa-miR-29a-3p TFDP2 -1.26881270980079 2.82496991513463e-22 0.425669422468068 0.0013716846266445 mirMAP -0.223240933060751 1.35384227818814e-07 NA NA NA hsa-miR-3614-5p TFDP2 0.955957969488529 2.95347675446694e-05 0.425669422468068 0.0013716846266445 mirMAP;miRNATAP -0.120182672698637 1.58615700919407e-06 NA NA NA hsa-miR-365a-3p TFDP2 0.446833934952926 0.00233857759218299 0.425669422468068 0.0013716846266445 mirMAP -0.129478038953112 0.00104857935763309 NA NA NA hsa-miR-584-5p TFDP2 0.458655788667031 0.0421764547676754 0.425669422468068 0.0013716846266445 mirMAP -0.198329953946454 2.40170771915643e-15 NA NA NA hsa-miR-139-5p TGFB1 -1.46099200329485 7.85040381494472e-22 1.63261254184582 2.57292771878501e-37 miRanda -0.211396728970549 1.66114173348681e-08 NA NA NA hsa-miR-29b-3p TGFB1 -0.110721443686039 0.511264554091106 1.63261254184582 2.57292771878501e-37 miRTarBase -0.115557141630177 0.00118189427407973 NA NA NA hsa-miR-141-3p TGFB2 0.730011517758706 0.000120338355004032 0.0777328362726655 0.723018455166753 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.265467824704804 8.27771461885267e-08 NA NA NA hsa-miR-142-3p TGFB2 1.12754191614028 1.68798138028946e-08 0.0777328362726655 0.723018455166753 miRNATAP -0.16064296699396 0.000634225971259789 NA NA NA hsa-miR-149-5p TGFB2 0.443278770827687 0.0642022866136881 0.0777328362726655 0.723018455166753 MirTarget;miRNATAP -0.224915548613611 1.07874560543081e-08 NA NA NA hsa-miR-200a-3p TGFB2 0.607140814457753 0.00289840524858752 0.0777328362726655 0.723018455166753 MirTarget;miRNATAP -0.245845232906061 1.05145500844554e-07 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 0.0441399794719697 0.880456392176704 0.0777328362726655 0.723018455166753 MirTarget -0.213491686707761 2.34238525013733e-11 NA NA NA hsa-miR-29b-3p TGFB2 -0.110721443686039 0.511264554091106 0.0777328362726655 0.723018455166753 miRTarBase;MirTarget;miRNATAP -0.160451483561471 0.00470479835294533 NA NA NA hsa-miR-33a-3p TGFB2 0.20371038027126 0.212335697664505 0.0777328362726655 0.723018455166753 MirTarget;mirMAP -0.284781670411935 1.38897599512622e-06 NA NA NA hsa-miR-362-5p TGFB2 0.41089772861323 0.0404254902071382 0.0777328362726655 0.723018455166753 MirTarget -0.221176820672115 2.86666724884053e-06 NA NA NA hsa-miR-429 TGFB2 0.559451508722375 0.00563641638673083 0.0777328362726655 0.723018455166753 miRNATAP -0.213199102441814 5.30129859548984e-06 NA NA NA hsa-miR-454-3p TGFB2 1.54137391927201 4.15861570449376e-20 0.0777328362726655 0.723018455166753 MirTarget;miRNATAP -0.160741300174909 0.00334509150397591 NA NA NA hsa-miR-500a-5p TGFB2 0.675401699376111 8.24389004707854e-05 0.0777328362726655 0.723018455166753 mirMAP -0.159447320526312 0.00397529568273535 NA NA NA hsa-miR-500b-5p TGFB2 0.674875511637057 8.39602242688137e-05 0.0777328362726655 0.723018455166753 MirTarget -0.160233047874767 0.00378717200794635 NA NA NA hsa-miR-589-3p TGFB2 1.59559692667315 6.2886410639161e-15 0.0777328362726655 0.723018455166753 MirTarget -0.123357495887196 0.00914033095581057 NA NA NA hsa-miR-590-5p TGFB2 0.763025362395968 3.65305892505623e-09 0.0777328362726655 0.723018455166753 miRanda;miRNATAP -0.342026904103455 2.39104051032236e-06 NA NA NA hsa-miR-944 TGFB2 1.47323925060177 2.61626403984929e-13 0.0777328362726655 0.723018455166753 mirMAP -0.166241708180204 0.000315071117627543 NA NA NA hsa-let-7a-3p TGFB3 0.0966652362351867 0.423761916840503 1.00893266823856 2.40088713170131e-07 MirTarget -0.216799599468632 0.00248516203461445 NA NA NA hsa-miR-26b-3p TGFB3 0.421575313079363 0.00223298166810883 1.00893266823856 2.40088713170131e-07 MirTarget -0.227871116558054 0.000253998125314173 NA NA NA hsa-miR-29b-3p TGFB3 -0.110721443686039 0.511264554091106 1.00893266823856 2.40088713170131e-07 miRTarBase -0.233447034464102 4.45758973897005e-06 NA NA NA hsa-miR-590-3p TGFB3 0.221436901462551 0.0965904764063157 1.00893266823856 2.40088713170131e-07 miRanda -0.212001265861609 0.00106335445516084 NA NA NA hsa-miR-629-3p TGFB3 1.43262037314105 2.37092217984413e-19 1.00893266823856 2.40088713170131e-07 MirTarget -0.176865315949139 0.000694496344538885 NA NA NA hsa-miR-27a-3p TP53 0.348456440505425 0.00126682892514312 -0.41755807197951 0.03001853518726 miRNAWalker2_validate -0.202518579356515 0.009421402460679 NA NA NA hsa-miR-139-5p TTK -1.46099200329485 7.85040381494472e-22 1.58386491735199 9.79060899849686e-29 miRanda -0.215849016952399 1.46206118913392e-07 NA NA NA hsa-miR-338-5p TTK -1.71946558699173 2.62649071488641e-23 1.58386491735199 9.79060899849686e-29 PITA -0.126880959590384 0.000464328628582499 NA NA NA hsa-miR-542-3p WEE1 0.643308814904977 8.81635403230104e-07 -0.446529703591802 0.000273441769242306 miRanda -0.129566211319418 0.00146626890677003 NA NA NA hsa-miR-181c-5p YWHAB -0.168991199007857 0.196949106150297 0.00881901233011639 0.898873897369249 mirMAP -0.162599760897484 5.80022917244678e-13 NA NA NA hsa-miR-218-5p YWHAB -1.0725338636959 3.61493686604269e-09 0.00881901233011639 0.898873897369249 MirTarget;miRNATAP -0.129695867674064 2.61732110074287e-16 NA NA NA hsa-miR-28-3p YWHAB 0.459875450032895 3.47095927872566e-07 0.00881901233011639 0.898873897369249 mirMAP -0.121898698299706 0.000245458193878681 NA NA NA hsa-miR-26a-5p YWHAE -1.09269574587169 1.24020612216319e-22 -0.011693142597748 0.858085854108992 miRNAWalker2_validate;miRNATAP -0.134851355513539 2.34107313476958e-08 NA NA NA hsa-miR-30e-3p YWHAE -0.890635378639789 1.65740480611339e-16 -0.011693142597748 0.858085854108992 miRNAWalker2_validate;MirTarget -0.122782409777311 1.32307601654417e-06 NA NA NA hsa-miR-140-3p YWHAG -0.967453553824782 7.6999446305445e-23 0.330299865053775 0.000136511662733804 MirTarget;PITA;miRNATAP -0.103358457091299 0.00540157523681645 NA NA NA hsa-miR-148a-3p YWHAG -0.428944290834563 0.00954246923521465 0.330299865053775 0.000136511662733804 mirMAP -0.172562576929802 9.80841062387561e-15 NA NA NA hsa-miR-148b-3p YWHAG 0.386859166050437 4.6728211830726e-06 0.330299865053775 0.000136511662733804 mirMAP -0.127068459520355 0.00478750444470103 NA NA NA hsa-miR-181c-5p YWHAG -0.168991199007857 0.196949106150297 0.330299865053775 0.000136511662733804 MirTarget;miRNATAP -0.179801848435716 3.17700531037192e-10 NA NA NA hsa-miR-186-5p YWHAG 0.353452958261612 0.000145058448579496 0.330299865053775 0.000136511662733804 mirMAP -0.148835514391217 0.000264572338061396 NA NA NA hsa-miR-200a-3p YWHAG 0.607140814457753 0.00289840524858752 0.330299865053775 0.000136511662733804 MirTarget;miRNATAP -0.109714904319702 1.84079025598854e-09 NA NA NA hsa-miR-200b-3p YWHAG 0.0717138787925347 0.682858087587209 0.330299865053775 0.000136511662733804 MirTarget;TargetScan -0.119044631431967 2.4988893127847e-08 NA NA NA hsa-miR-30a-5p YWHAG -1.79779915425811 1.93360169837799e-26 0.330299865053775 0.000136511662733804 miRNATAP -0.146711637270905 2.05639265713117e-12 NA NA NA hsa-miR-30b-5p YWHAG -0.400238605368173 0.00346540992719245 0.330299865053775 0.000136511662733804 miRNATAP -0.157165643805315 8.77435645310602e-09 NA NA NA hsa-miR-30c-5p YWHAG 0.021222006155897 0.886366656528128 0.330299865053775 0.000136511662733804 miRNATAP -0.175640843750997 2.47764574936125e-12 NA NA NA hsa-miR-30d-5p YWHAG -0.38399848121878 0.000171129616944749 0.330299865053775 0.000136511662733804 miRNATAP -0.150426546243279 4.79824419705503e-05 NA NA NA hsa-miR-30e-5p YWHAG -1.02114836019762 6.81961221797866e-17 0.330299865053775 0.000136511662733804 miRNATAP -0.238931774160398 3.47283564025138e-16 NA NA NA hsa-miR-320a YWHAG 0.801356001806321 4.91397101474502e-09 0.330299865053775 0.000136511662733804 PITA;miRanda;miRNATAP -0.109092478160448 6.02904259165254e-05 NA NA NA hsa-miR-342-3p YWHAG 0.99756868977753 9.28499866272332e-10 0.330299865053775 0.000136511662733804 miRanda -0.129680704448062 9.51810845665504e-09 NA NA NA hsa-miR-361-3p YWHAG 0.272298288982435 0.0147874880476998 0.330299865053775 0.000136511662733804 miRNATAP -0.215264671621153 1.33485624045165e-10 NA NA NA hsa-miR-625-3p YWHAG 0.0858338965684338 0.484971431380441 0.330299865053775 0.000136511662733804 MirTarget -0.17427169354784 1.24901421052461e-08 NA NA NA hsa-miR-361-5p YWHAH 0.0803683277369505 0.314043140368058 0.606590747915194 2.2258270392452e-20 miRanda -0.143754438817592 0.000129662085983515 NA NA NA hsa-miR-140-5p YWHAQ -0.412389003031485 0.000136051708543369 0.297188016762384 0.000301717728960227 miRanda -0.144369110796683 1.28394289726585e-05 NA NA NA hsa-miR-320a YWHAQ 0.801356001806321 4.91397101474502e-09 0.297188016762384 0.000301717728960227 MirTarget;PITA;miRanda;miRNATAP -0.122791197390879 1.79476954628365e-06 NA NA NA hsa-miR-328-3p YWHAQ 0.153404163477345 0.292356842798574 0.297188016762384 0.000301717728960227 miRNAWalker2_validate -0.14067106382548 8.41883816895344e-09 NA NA NA hsa-miR-497-5p YWHAQ -0.966244470847844 5.26505649147857e-12 0.297188016762384 0.000301717728960227 MirTarget;miRNATAP -0.160727522583736 8.39459490325181e-11 NA NA NA hsa-miR-125a-5p YWHAZ 0.215366061934933 0.119550904549401 0.344806894705046 0.00159832448868044 miRanda -0.131737820968702 0.000133229843462919 NA NA NA hsa-miR-140-3p YWHAZ -0.967453553824782 7.6999446305445e-23 0.344806894705046 0.00159832448868044 MirTarget;PITA;miRNATAP -0.332612441544844 4.02857377845901e-13 NA NA NA hsa-miR-195-3p YWHAZ -0.624259620429699 0.000164279659144497 0.344806894705046 0.00159832448868044 MirTarget -0.179161299851689 2.75832505706067e-10 NA NA NA hsa-miR-217 YWHAZ -1.35391381055929 2.42394951427902e-09 0.344806894705046 0.00159832448868044 miRanda -0.115379904046822 1.65379610658317e-08 NA NA NA hsa-miR-28-5p YWHAZ -0.026996999089909 0.733047113251652 0.344806894705046 0.00159832448868044 PITA;miRanda;miRNATAP -0.460593947828525 1.51249556078375e-14 NA NA NA hsa-miR-30a-5p YWHAZ -1.79779915425811 1.93360169837799e-26 0.344806894705046 0.00159832448868044 miRNAWalker2_validate;MirTarget;miRNATAP -0.257456100150205 1.20682025865332e-23 NA NA NA hsa-miR-30b-5p YWHAZ -0.400238605368173 0.00346540992719245 0.344806894705046 0.00159832448868044 MirTarget;miRNATAP -0.134959972136251 0.000102257748497268 NA NA NA hsa-miR-30c-5p YWHAZ 0.021222006155897 0.886366656528128 0.344806894705046 0.00159832448868044 MirTarget;miRNATAP -0.158375500764273 7.34079247818284e-07 24519092 Involvement of miR 30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells; Together our findings provided evidence that miR-30c was one of the important miRNAs in doxorubicin resistance by regulating YWHAZ in the breast cancer cell line MCF-7/ADR drug resistance breast cancer hsa-miR-30d-5p YWHAZ -0.38399848121878 0.000171129616944749 0.344806894705046 0.00159832448868044 MirTarget;miRNATAP -0.182363700762594 9.34714131398731e-05 NA NA NA hsa-miR-30e-5p YWHAZ -1.02114836019762 6.81961221797866e-17 0.344806894705046 0.00159832448868044 MirTarget;miRNATAP -0.287219608655415 8.9471584773708e-15 NA NA NA hsa-miR-320a YWHAZ 0.801356001806321 4.91397101474502e-09 0.344806894705046 0.00159832448868044 MirTarget;PITA;miRanda;miRNATAP -0.174562705304479 3.1139990151526e-07 NA NA NA hsa-miR-320b YWHAZ 1.23473838180754 3.04337566045537e-14 0.344806894705046 0.00159832448868044 MirTarget;PITA;miRanda;miRNATAP -0.1345921734285 2.20431003170386e-06 NA NA NA hsa-miR-328-3p YWHAZ 0.153404163477345 0.292356842798574 0.344806894705046 0.00159832448868044 MirTarget -0.158722107237606 1.12570217375833e-06 NA NA NA hsa-miR-335-3p YWHAZ 0.336785882180547 0.0542446207938138 0.344806894705046 0.00159832448868044 mirMAP -0.137412436277824 3.72360558086778e-07 NA NA NA hsa-miR-340-3p YWHAZ 0.289340144425255 0.0371281333347226 0.344806894705046 0.00159832448868044 miRNAWalker2_validate -0.13819894036917 5.61930086606928e-05 NA NA NA hsa-miR-374a-3p YWHAZ -0.299190081500425 0.00682975596757891 0.344806894705046 0.00159832448868044 mirMAP -0.235356330221876 4.04380116686581e-08 NA NA NA hsa-miR-378a-3p YWHAZ -1.50453783521372 9.41694954361173e-17 0.344806894705046 0.00159832448868044 miRNAWalker2_validate -0.138587190642273 4.20943927356468e-08 NA NA NA hsa-miR-3913-5p YWHAZ 0.48532077857571 0.00112373589405304 0.344806894705046 0.00159832448868044 MirTarget -0.119371212598511 0.000192155941997275 NA NA NA hsa-miR-423-5p YWHAZ 0.60141781325829 1.62940950644999e-07 0.344806894705046 0.00159832448868044 miRNAWalker2_validate -0.144999889763823 0.000434990684154854 NA NA NA hsa-miR-582-3p YWHAZ -0.248056267546012 0.143798829508405 0.344806894705046 0.00159832448868044 miRNATAP -0.14176604788771 3.76616387478394e-07 NA NA NA hsa-miR-582-5p YWHAZ -0.0366995972742474 0.821827119138923 0.344806894705046 0.00159832448868044 PITA -0.134128132346311 4.23230737234185e-06 NA NA NA hsa-miR-664a-3p YWHAZ -0.256108763664991 0.0513188660751664 0.344806894705046 0.00159832448868044 mirMAP -0.166079540885946 4.4590256821311e-06 NA NA NA hsa-miR-132-3p ZBTB17 0.237841736463996 0.00653466538179383 0.278649205456568 0.000233742536075844 MirTarget -0.159643988664299 2.6865952253546e-05 NA NA NA hsa-miR-212-3p ZBTB17 0.0427493354176791 0.789608223138427 0.278649205456568 0.000233742536075844 MirTarget -0.115904977091729 1.41997398624814e-08 NA NA NA